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John McWhorter
Marion Barry Could Have Been a Great Mayor in Any Other American City
November 23, 2014
How D.C. brought out the worst in its infamous mayor.
There Is Only One Real Way to Prevent Future Fergusons: End the War on Drugs
August 17, 2014
It has created the toxic dynamic between black boys and white police officers.
Saint Maya
May 28, 2014
There isn't much art in her books, but she helped pave the way for black writers who can enjoy the luxury of being merely individuals rather than representatives of their race.
That Viral Story About the Racist Ice Cream Song Is Wrong
May 16, 2014
A writer for NPR makes a bold argument—but without the necessary facts.
We've Been Told that Different Languages Create Different Worldviews. They Don't.
April 27, 2014
It's not language that makes people different, but the culture associated with the language.
Gawker is Trying to Use 'Adult' Language. Good Luck to Them.
April 07, 2014
Why try to avoid lingo? What's slang today is accepted usage tomorrow.
Let's Stop Pretending That French Is an Important Language
February 02, 2014
The idea that American-born children need to learn French has become more reflex than action, like classical music played at the wedding of people who live to modern pop.
A Gender-Neutral Pronoun Won't Work in English. We're Stuck With "She" and "He."
January 24, 2014
It would have saved Grantland some headaches, but it's hopeless.
Internet-Speak is Improving English Because Empathy
January 09, 2014
The real significance of the new "because."
This American Dictionary Is Full of Words You've Never Heard Before
December 18, 2013
There are way more words for soft drinks than just "pop" and "soda."


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Sometimes you just feel like saying hello. These cards fit my recent letter-writing mood perfectly. I adore the nostalgic designs. Remember rotary dial telephones? I sure do!
I made little packets of sweet dot stickers and tucked them into the envelopes. I love getting tiny surprises enclosed in letters, so here is hoping my penpals will be delighted too!
The letters were completed with current Queen postage, stamped with vintage-looking rubber stamps and sealed with gold and white striped washi tape. I'm off to the mailbox now.
Happy writing!

subset: commoncrawl


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Vax Rapide Spring Clean Carpet - Blue
Make your carpets look as good as new with the Vax Rapide Spring Carpet Washer. With 700W of power and 6 high pressure jets, you'll be able to quickly refresh your carpets. The lightweight design and 5.9 metre power cable makes it really easy to clean any room of your house, and with the 23cm cleaning width you'll be able to suck up even the biggest spills. - A.D.
- 2.6 Litre clean capacity
- 1.8 Litre Dirt capacity
- 6.5 Metre cleaning reach
- 6 Metre cable
- 23cm Cleaning width
- Lightweight - only 5.5kg
- Easy to use and set up
- Static brushbar
- Colour: Blue
Product Details
Delivery & Returns
Express Delivery - if ordered before 9pm, delivered by courier next working day. More Info »
How long will it take to arrive?
Please remember to add postal time (2-3 working days) to obtain a complete estimate of delivery to your door.
How will I know it has been sent?
You will receive an email to confirm when your item has been sent.
You can also check the status of your order and individual items by accessing My Account details and following the prompts.
Please allow 10 working days from dispatch of your order before notifying us of any late deliveries.
It may be advisable to check with your neighbours to see if a parcel has been left with them, check any outhouses you might have where it may be left if it cannot fit through your letterbox and contact your local sorting office to see if the item has been returned to the depot as undelivered and awaiting collection.
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does the job
Total :
only used it once so far but it removed alot of dirt from the carpet i was quite surprised. you have to take your time with it as it does tnd to leave lines of wet if you dont keep going over it enough the suck it all up, as quite good suction carpets are obviously a bit wet still after use but not soaking wet . good value for money overall.
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Excellent Service
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Ordered on Monday, received the following day. Really impressed with the ordering and delivery service which was free! The carpet washer was easy to put together and easy to use. I had read other reviews before I purchased so knew what I was buying. It is very lightweight unlike a Vax I had years ago which was unbelievably heavy. Consequently it is not going to deep clean as one with a much bigger motor but I think I will use it more often as we have dogs. The only thing I did find was that our old dog knocked over a water bowl and when I had mopped the surface water I used the Vax to suck up the rest from the carpet. I found that the motor wasn't powerful enough to do this.
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text:
Joseph Kennedy, Jr.Aviator / Political Relative
Born: 28 July 1915
Died: 12 August 1944 (wartime plane explosion)
Birthplace: Hull, Massachusetts
Best known as: The older brother of president John Kennedy
Joseph Kennedy, Jr. was the eldest son of Joseph Kennedy, Sr. and the older brother of future president John F. Kennedy. Like his brother John, he attended Choate and Harvard College; many people assumed that Joe Jr. would go on to become the family politician. He left Harvard Law School to join the Navy and served as a bomber pilot in World War II. He died when his plane, loaded with explosives for an attack on German V-2 rocket site, exploded shortly after takeoff. He was posthumously awarded the Navy Cross and the Air Medal for heroism. The Joseph P. Kennedy Jr. Foundation, which supports people with mental disabilities, was founded in his honor by the Kennedy family in 1946.
Extra credit: His sister Eunice Kennedy Shriver became head of the Joseph P. Kennedy Jr. Foundation in 1957; she created the first Special Olympics in 1968... Many sources list his birthplace as Boston, Massachusetts. However, his brother Edward points out in his 2009 book, True Compass, that Joe Jr. "arrived at a summer house in Hull... in 1915." Hull is a small town on the water about 10 miles southeast of Boston.
Copyright © 1998-2015 by Who2?, LLC. All rights reserved.
More on Joseph Kennedy Jr from Infoplease:


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Minnesota 99, Clippers 96
Posted by Kevin Arnovitz on Sun, 03/09/08, 12:28pm:
Anytime you try to look at something like basketball through the lens of The Organon, you're destined to fuck yourself silly. Last night, Cuttino Mobley entered the game with about eight minutes remaining and an eight point Clipper lead. What was notable about the substitution was that Mobley replaced Dan Dickau at point guard. Dunleavy toyed briefly with the experiment a couple of nights ago in a less consequential context, but last night – with Dickau and Andre Barrett as his only other options – he formally cast his lot with Mobley down the stretch.
The Clippers relinquished their lead and wound up losing by three – a net -11 while Mobley was manning the point. The question is one of causality: Did Mobley handling PG duties propel the Clippers to the loss?
Good question and one I'm not comfortable answering. On one hand, it probably makes sense for the Clips to field their best offensive lineup as much as possible. And in a game when the ball is being walked up the floor, is it really worth handing minutes to the likes of Dickau or Barrett when a player like Mobley, though not a great ballhandler, could probably do the job?
Mobley handles the point for 14 possessions down the stretch. The Clippers converted a score on six of those possessions. Let's take a look at a sample
- [4th, 7:39] The first Mobley-at-point possession is pretty ugly. The ball crawls its way around the perimeter: Mobley-Ross-Thornton-Mobley-Ross. Finally, Ross recognizes that he's got Randy Foye a little bit off-balanced and it's a run to daylight. He drives down the gut of the lane. Most of the Minnesota defense stays at home and Ross converts the layup.
Still, the set is completely inert.
- [4th, 7:16] Early in the possession, Mobley gets a high screen from Josh Powell. Cat doesn't waste anytime penetrating against the Minnesota zone. But his left-handed drive to the hoop results in a missed layup.
Not a bad call, but a terrible finish by Mobley.
- [4th, 6:33] The Clips now have their full offensive lineup on the floor: Mobley-Maggette-Thornton-Thomas-Kaman. Again, the ball is worked around the arc and never reaches the post. With :05, Maggette gets a pretty open look at a 3PA, but he misses. Kaman grabs the offensive board, but his putback doesn't fall.
- [4th, 5:56] Another perimeter circle jerk that results in a Thornton 21-foot miss. The Clips get another shot after a loose ball foul, during which they actually work themselves a shot in the paint – a bouncy Tim Thomas hook shot that clanks. Kaman's attempted tip doesn't go either.
- [4th, 5:07] A two-point game now, as the vaunted, impenetrable Minnesota Timberwolves 2-3 strangles the Clips. More merry-go-round. Maggette tries and fails to get an entry pass into Thomas on the left block. The Clips get the benefit of the out-of-bounds call and get it back. The ball returns to the perimeter. Maggette decides to create. As his drive enters the paint, he tries to pass it out to an open Mobley, but Marko Jaric tips the pass and we go the other way.
- [4th, 4:46] A redux of the last possession, but here Maggette finds his way to the rim with a potent drive.
- [4th, 4:18] The Clips try Thomas again in the post against Corey Brewer. Thomas gets fouled on the turnaround hook and converts both FTs.
- [4th, 3:38] The game is tied. Again, Maggette darts an entry pass into Thomas on the left side of the box. Ryan Gomes has the matchup now and he reads the hook shot well. The shot is way off.
- [4th, 3:00] The Clippers work more quickly here and find Kaman low – but not in a terribly advantageous position along the baseline. Kaman doesn't like to receive the ball that deep…and the T-Wolves sense it. They send Jefferson to double. Kaman is in a horrible position to pass out from, and his cross-court pass almost gets tipped away, but somehow ends up in Maggette's hands. Maggette elevates for a shot he doesn't have, but on his way down, he shoots a baseline pass to Kaman, who pump-fakes, then goes up and draws the foul. Chris coverts both FTs.
- [4th, 2:23] More circular motion. At :13, Thornton dumps it into Kaman at the foul line. McCants, who had been on Thornton, takes the bait and drops, so Kaman wisely gets it back to Thornton for the 3PA at the top of the arc. It doesn't go.
- [4th, 1:39] The Clips trail by two. They pass it around the arc again until :11. Finally, Mobley dumps it into Kaman off the right post – in a somewhat better spot than before. The double-team comes, so Kaman passes it back outside to Maggette on the arc. There's good news: When Kaman got the ball, the T-Wolves' zone constricted the inside so tightly, that now Mobley is alone in the left corner. The Clips work the ball around to Cat and he sinks the 3PM.
Clips by one.
- [4th, 1:00] The Clips have found their formula: Dump it into the big man, let the defense collapse while spreading the arc. So long as the shots go down, it works. Again, Mobley gets into Kaman off the mid-right post. This time, the double comes from the perimeter though. This leaves Mobley, who has just delivered the entry pass, wide open along the far sideline for a 3PA. Kaman quickly shuttles the ball back to Cat, but this time Cat misses.
- [4th, 0:03] You know the rest of the story. The Clips get the ball back with :10.5, trailing by three after Foye hits the circus shot off the pane. Minnesota goes with a man-to-man. Thornton inbounds the ball to Cat about 30 feet from the basket. Cat dribbles left while Corey weaves right. Corey gets the handoff at about 26 feet at :07.8. The misdirection and the high Thomas screen have given Corey some space, but he elects to drive against Foye and pull up for an 18-foot J with :03.0 remaining.
I mean, not a bad option…five seconds earlier. The replay is funny because, as Corey shoots it, Dunleavy slumps back in his chair and extends his hands, palms upwards: What. The. Fuck.
And the excited face of Dan Dickau drops as quickly as his arms -- which had elevated upward in a 3PM gesture as Corey receives the ball beyond the arc -- just as Corey turns the corner into 2PFG-land.
As Corey approaches the bench after the make with the ol' dog-devours-homework look, Dunleavy, red-faced, tries to discern some intelligible rationale from Corey as to what he was thinking. Jim Eyen sort of rolls his eyes in the background.
Corey Maggette finishes the night with 29 points.
- [4th, 0:00] After Ross intentionally fouls Foye quickly, Foye makes both FTs and the Clips get it back with :02.4. This time, Thomas is on the inbound.
It's a really sweet play. Seriously. Mobley is directly in front of the sideline and Thomas. Kaman is at the top of the key. Chris steps out to set a strong screen on Foye that allows Mobley to dash undeterred and unmanned to the far left corner. Foye picks up Maggette who has cut from the near side to the inbounder. Kirk Snyder, who had Maggette initially, is totally crossed up as Thornton sprints from underneath the hoop back up top as the third option.
Thomas heaves a perfect pass across the court to Mobley in the corner. Cat has plenty time to catch, set, and launch…but he overshoots the hoop and it catches air.
I'm still uncommitted on the question as to whether the Clips need a true point in the game if that PG happens to be named Dan Dickau or Andre Barrett. It's also worth noting that the Minnesota Timberwolves score 24 points in the final eight minutes, largely because the Clippers' help defense on Minnesota penetration is awful. The Wolves don't shoot much from the perimeter, but they'll drive the lane and, to the extent the Minnesota Timberwolves can force anyone to do anything, they force the opposing defense to make decisions on help. Who's going to pick up Foye once he blasts past Mobley on that high Jefferson screen? And if Jefferson slides that screen, who's gonna pick his big ass up?
The Clips did a reasonably decent job figuring this stuff out most of the way, but came completely unglued in the defensive halfcourt just about the time they became rudderless on the offensive end. I think it's coincidence because Dan Dickau isn't going to help your ballclub defend Randy Foye, even if Cuttino Mobley can't help your ballclub break a facile zone.


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Marketplace Activity
Community Inventory Summary
Market Pricing
Average Retail:
$982.80 Details
$982.80 Details
Avg Auction:
(of 9 listings - 12 months ) $773.90 Details
(of 9 listings - 12 months ) $773.90 Details
1970 Vega Sicilia - Unico Regional Blend - Spain - Castilla y Leon - Ribera del Duero - Red
Spain - Castilla y Leon - Ribera del Duero
Regional Blend
Producer Notes
Vega Sicilia is Spain's most well known and prestigious estate. It was founded in 1864 by Don Eloy Lecanda y Chaves, who brought vine cuttings from Bordeaux of Cabernet Sauvignon, Malbec and Merlot to plant alongside Tinto Fino. Vega Sicilia's 3 cuvees include the flagship "Unico," a multi-vintage blend called "Reserva Especial," and the more forward-style Valbuena.
Drink DatesComm: 2010-2025 VF: 2001-2021
Community Tasting Notes average score of 97 points based upon 1 reviews


text:
Welcome to Smogon! Check out the Smogon Info Hub for everything you need to know about starting out in the community. Don't forget to introduce yourself in the Introduction Thread, too!
Welcome to Smogon Forums! Please take a minute to read the rules.
Final Fantasy III Mafia- Warriors of Light and askaninjask Win!!!
Discussion in 'Circus Maximus: The Competitive Mafia Hub' started by Acklow, Aug 22, 2010.
Page 16 of 16
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Fully checked, factory-covered and ready for more adventures.
Compare Subaru models and other car manufacturers.
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Since 1949, car enthusiasts have waited and watched for Motor Trend's annual, coveted vehicle awards – considered by enthusiasts and savvy consumers to be the pinnacle of praise by the popular automotive press.
There's only one car … one truck … and one SUV selected by Motor Trend's discerning staff. Needless to say, Subaru is excited and honored, because being selected for a Motor Trend award is no easy achievement.
"This award validates all the hard work we put into our vehicles to make them the best they can be. The engineering, the innovation, the design, safety, and durability. These are all the things we measure ourselves against. Now it's nice to know these are the same criteria that Motor Trend recognizes us for as well," said Thomas J. Doll, president and chief operating officer, Subaru of America, Inc.
The award is not subjective. To determine who takes top honors, Motor Trend's staff thoroughly evaluates the entire auto industry's current lineup of new SUVs. They look at:
Making these evaluations, the Motor Trend staff fell in love with the Forester. You can read in detail what they have to say about the Forester in Motor Trend's December 2013 issue.
Motor Trend recognized the all-new 2014 Subaru Forester as the top Sport/Utility of the year from a highly competitive field of SUVs. Equally impressive is that Motor Trend has chosen two generations of Forester for this prestigious award – the 2009 and 2014 versions. (And Outback won it in 2010!)
Plus, this isn't the only honor garnered by the 2014 Forester. It has earned the highest ratings from the Insurance Institute for Highway Safety (TOP SAFETY PICK +)1 and the National Highway Traffic Safety Administration (five stars).
Learn more about the new 2014 Forester, and read about it in Drive Performance Version 10.1, and in the Spring 2013 and Summer 2013 issues of Subaru Drive magazine.
The all-new Subaru Forester. Motor Trend's 2014 Sport/Utility of the Year®. A whole lot to love!
1 Ratings based on Insurance Institute for Highway Safety's (IIHS's) 40-mile-per-hour frontal crash test, 31-mile-per-hour side-impact test, 20-mile-per-hour rear-impact test, and roof-strength test. For more information, contact IIHS or visit their website at iihs.org.
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Favourite CAP
Discussion in 'Create-A-Pokémon Project' started by SgtWoodsy, Nov 17, 2012.
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What is the safest hard drive format (NTFS, HFS+, XFS, ZFS, ...) for archiving or/and storing media (data)? I'd prefer to have the data not corrupt and be relatively safe (From corruption, ...) and would like to have the format to be accessible by Windows (Vista) as well.
Thanks in advance.


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While there were many lovely head-to-toe pajama looks on the runways this season, we found inspiration for today's story in Jenni Kayne's wearable, everyday approach to this trend. The Los Angeles-based designer showed a handful of silky, bed-inspired separates in her F/W 11 show, juxtaposed with chunky knits and oversized outerwear. In the look shown above, Kayne tempered the seductive spirit of the rust-colored Bias Scoop Neck Dress ($650) by simply adding the double-breasted tweed Over Coat ($695). The result is a chic ensemble you can take out of the bedroom and into to a fashion party! The look is equally accessible off the runways too, as you can see from the ensemble Jade Williams wore to Fashion's Night Out in London last month. Williams tried a styling trick similar to the one seen at Kayne's presentation, and balanced the casual vibe of Topshop's Polka Dot Wide Leg Trousers ($90) with a few sophisticated and polished elements, including Topshop's Leather Collar Wool Boyfriend Coat ($340) and a Ralph Lauren white-button-up shirt.
Of course, slip dresses and silky trousers aren't the only way to execute pajama dressing! Just last month we spotted Vogue.com contributor Stephanie LaCava at a party feting Jason Wu at the St. Regis Hotel in New York, and did a double take at the sight of her chic, robe-like outfit, which she achieved by wearing a white Petit Bateau t-shirt underneath Thakoon's Printed Cotton Dress ($1550). In addition to LaCava's eye-catching frock, we also approve of the white Louis Vuitton suit Elisa Sednaoui wore to the Dark Horse premiere in France last month. Her jacket and trousers definitely have that pajama-set look, however, the fitted tailoring and black trim make it an unexpectedly chic red-carpet ensemble. One thing's for sure: Hugh Hefner must be jealous!
Now that you're familiar with the many wonderful ways you can address this trend, we'd like to bring some fabulous pajama-inspired products to your attention! First on our must-buy list is Tommy Hilfiger's Foulard Chiffon Long Shirt Dress ($698). This straight-off-the-runway button-up frock features a luxurious fabric and pretty paisley print, while its striped sash gives the dress a robe-like look a la Stephanie LaCava. If you'd rather work with some separates, then you simply must try Rag & Bone's PJ Blouse ($325) in Gray or Shakuhachi's floral-emblazoned Short Sleeve Shirt ($176); either top would look smart worn with a slim midi skirt. We also adore Topshop's Mustard Daisy Print Pyjama Style Jacket ($110); the print is quite cute and the bright yellow hue is a spot-on choice for fall. If you consider yourself an advanced dresser, and want to go for a total PJ look, we suggest pairing the jacket with Topshop's cream-colored Vintage Embroidered Slip ($76). And while the temperatures are still warm, be sure to snag LNA's Silk Zip Shorts ($74), which come in the most fantastic gold hue and are incredibly comfortable.
Photo of Elisa Sednaoui, courtesy of Getty; Photo of Stephanie LaCava, courtesy of Billy Farrell Agency; Photo of Jade Williams, courtesy of Wenn.


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By JOHN SERFUSTINISun Advocate associate editor
It is a necessary job they do, a public service that cannot be left undone.
But the bottom line is that the job is finding human bodies, and cadaver dogs cannot find those bodies until they've been dead for a while.
"It takes about two days," explained Tina Hendricks, who recently placed third - with her dog, Thumper - in statewide competition of the Utah Peace Officers Association for specialty dogs.
Hendricks and Arlinn Williams, who placed second, earned congratulations from Sheriff James Cordova for the high showing.
Williams's dog Kaya was also congratulated, but couldn't hear it because she is deaf. But it's the nose that counts in this business, not the ears.
Those noses get training, as do the noses of drug and bomb sniffing dogs, but this is a bit different.
The cadaver dogs are trained to recognize the scent they are sniffing for with such things as scraps of clothing provided by the State Medical Examiner, Hendricks said.
Those scraps don't come from people who are newly dead, either.
As Hendricks explained it, "When we're alive, we all have our own scent, like finger prints. But when we're dead, we all smell the same."
Decomposing human bodies exude a common chemical mix that the dogs are trained to seek.
Whether the bodies are out in the open, hidden, even buried, the dogs can find them. In fact, according to the sheriff, dogs have been known to find ancient burial sites. Given time, he explained, the smell of decomposition will move up through the earth and remain a long, long time.
The dogs showed their usefulness two years ago in preventing a tragedy from becoming worse. An adult and two children were killed and buried by a mudslide in Logan. It took 47 hours, but dogs found the bodies, which were gently removed.
"It prevented the bodies from being desecrated by the heavy equipment that was removing the mud," the sheriff noted.
The dogs a kept in readiness by regular training. Sometimes the trainers will stage something akin to a scavenger hunt. "We give hints like, 'Look for a place where the food is free but you don't want to eat there.' That means the jail, so we'll go out and search around the jail."
The competition involved hunting for evidence in rooms and burials, and was timed. In addition to that, the dogs had to show caution in investigating what may be a crime scene, meaning they could not move or damage anything and definitely not leave anything behind.
Kaya can't listen to commands, but she does just fine because she understands sign language, Williams said.


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- Northern New York Newspapers
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A Watertown teenager admitted Monday in Jefferson County Court that he participated in the robbery attempt of another teen in which a pellet gun was displayed.
Jesse R. Davis, 17, whose last known address was 639 Olive St., pleaded guilty to second-degree attempted robbery. He, along with two others, had been accused in a grand jury indictment handed up in November with robbing a 15-year-old boy of his wallet and cash while displaying what appeared to be a handgun Nov. 7 at Maywood Terrace. Police said at the time that $270 was taken from the youth.
He is expected to be sentenced March 25 to an unspecified amount of time served at the Metro-Jefferson Public Safety Building and five years probation. Nicholas Vanzelf, 20, Watertown, pleaded guilty Dec. 21 to third-degree attempted robbery for his involvement and also is expected to be sentenced to time served at the PSB and five years probation at his Feb. 8 sentencing. Charges against Cody L. Davis, 18, Watertown, remain pending.
In other court activity, Gary W. Hamill Jr., 30, Carthage, pleaded guilty to felony driving while intoxicated, admitting that he drove while intoxicated Oct. 27 on Brown Street in Carthage. Sentencing will be at a later date.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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Project Traveller Raids
Project Traveller Raids
Palabras clave
A woman is lead out by police into a cruiser as police raid buildings... Fotografía de noticiasAdulto,Canadá,Coche de policía,Concentración,Cuerpo de policía,Derecho,Estructura de edificio,Gobierno,Horizontal,Mujeres,Política,TorontoPhotographer Steve RussellCollection: Toronto Star 2013 Toronto StarTORONTO, ON - JUNE 13: A woman is lead out by police into a cruiser as police raid buildings at 320, 330 and 340 Dixon Road, concentrating on 320. Police in tactical gear were working with the Guns and Gangs unit. Toronto Police launched a massive predawn raid on June 13, 2013, targeting guns and drugs. The focus is on the Toronto neighbourhood thats ground zero for the Mayor Rob Ford crack video scandal. (Steve Russell/Toronto Star via Getty Images)


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People vs. the State of Illusion
Exalt Films, and Movies From The Heart, are proud to present People v. The State of Illusion, a film by Austin Vickers. This feature length documentary/drama, directed by award winning Director Scott Cervine, is set in the notorious "Old Main Prison" of the New Mexico State Penitentiary, and tells the story of Aaron Roberts, a single father who loses his daughter to a state facility after he is arrested and tried on charges following an incident. While in the state home, an attorney learns of her plight and the story of her father, and decides to represent her in an innovative and surprising case against the State.
Produced by: Austin Vickers
Directed by: Scott Cervine
Written by: Austin Vickers
Running time: 1hr 20min
Opens: Sep 09, 2011 Limited
|Theaters for Today
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Theorie Green Tea Shampoo and Conditioner Duo
We know you want the goods as soon as possible, which is why orders received by 3pm ET leave our warehouse the very same day. We'll send you an email that day to confirm shipment and the email will include your tracking information.
Our warehouse is closed Saturday & Sunday, so orders received after 3pm ET on Fridays will not ship out until Monday.
Based on 2 Reviews
HayleyBostonHairBlondeColor Treated HairFine or Thin HairFantastic!I have tried many different natural shampoos and conditioners, both salon and drugstore brands, and Theorie is by far the best. My old favorite product was discontinued a couple years ago and I have finally found a replacement- that is better!- in Theorie.
I have long, fine, color-treated hair and I love how the Green Tea Shampoo and Conditioner smooths and moisturizes without weighing my hair down. When I first started using (just the shampoo at first) my hair was so smooth my elastic kept falling out. I should also note that for the past 3 years or so I have struggled with an itchy, flaky scalp, and this is the only line I have found that cleanses well, conditions, and soothes instead of further irritating my scalp.
Last night I had my first hair appointment since starting to use both the shampoo and conditioner and my stylist said, "Your hair feels GREAT!" She has taken care of me for at least 10 years and has never given me that feedback before. I'm so glad I found this product!8 out of 8 shoppers thought this review was helpful.
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Raimey G.Richmond, VAHairDark BrownColor Treated HairThick or Coarse HairSomething Finally Helped My Dry, Damaged Hair!I used to have long hair (down to my waist), but as I got into my later 20's my hair changed. I tried everthing. I spent thousands of dollars on masques, treatments, shampoos, conditioners, vitamins...anything that I thought would work. It go to the point that my hair was so dry, brittle, and damaged that I cut it off to just above my shoulders. I spoke with my stylist about it, and she mentioned that she uses sulfate/sulfite free products in her hair. I bought what she uses, but still my hair looked awful! I found Theorie green tea shampoo and conditioner and figured that I'd give it a shot...what could it hurt. I am so glad that I did! After 1 week of using this duo my hair is soft, shiny, silky, and manageable! My fiance has noticed and I'm not constantly in a ponytail. I popped in to see my stylist and she was AMAZED! So amazed in fact, that she is going to order these products for herself. I love the scent, the thick (but not overly heavy) texture of the conditioner...everything! Theorie products are my new staple. I'll never go back to anything less!8 out of 8 shoppers thought this review was helpful.
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Flying Fish T-Shirt (Men's)
Out of Stock Product Number: 28588
Those who say fish can't fly probably say they can't hunt either. We know better. The Flying Fish T-Shirt's original artwork by Geoff McFetridge is printed on supersoft organic cotton. The shirt features taped shoulder seams for a no-chafe fit; double-stitched sleeves and hem add durability. Coverstitching at the neck and armholes lends a clean finish.
* This product does not qualify for shipping to all countries.
- Ringspun long-staple cotton for softness and durability
- Screen-print inks are PVC- and phthalate-free
- Taped shoulder seams for comfort and fit retention
- Artist: Geoff McFetridge
- 5.4-oz 100% organic cotton
Gender: Men's
Material: 5.4-oz 100% organic cotton
Season: F14
Vendor ProductId: 51602
Review ProductId: 24166


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"Just ignore him and hopefully he'll go away."
Looks like NBC is pulling out the big celebrity guest star guns for this week's live episode of "30 Rock." Jon Hamm and Matt Damon are confirmed to appear as the men after Liz Lemon's heart. Plot details are under wraps so we don't know whether or not Damon will pull a Duck Phillips and try to crap in Alec Baldwin's chair before picking a fight with Hamm. Tracy Morgan more than likely will though. That guy pretty much craps anywhere and everywhere. (EW)
In this official pic from Tron Legacy, Daft Punk looks like Daft Punk, but cooler! Look at the blue. I want to go to there. This sneak peak at the French duo is the kickoff of what Disney is calling Tron Tuesdays, which will see the release of new materials for the film every Tuesday for the next ten weeks as the film's release date approaches. I would be happy if they just released a new Daft Punk track from the film's score every week.
Oh, look what else we have. A new Daft Punk track from the film's score. The first 90 seconds of "The Game Has Changed" gets me so amped for the film that I want to cram a Cat 9 cable into the gapping hole at the base of my skull. I've always assumed that's the reason it's there anyway.
Check out the killer track after the jump…
You know a Jackass movie is going to have a lot of male nudity. They had it on the old MTV show but they just blurred it out with a…
Thanks to the Blu-Ray release of Back To The Future, long-rumored footage of Eric Stoltz as Marty McFly has finally surfaced. What are you doing in there, Eric Stoltz? You are not a Marty McFly. You are an Eric Stoltz.
A bit of background, Stoltz was originally hired for the lead role but then replaced by Michael J. Fox after five weeks of filming. Fans have talked about the existence of this footage, but few have seen it. It's bizarre yet awesome to see after all this time. Now that this is out of the way, can we get back to work on making Hover Boards real?
Check out the bizarro universe footage after the jump…
Donald Glover did not succeed in his campaign to become the first black Spider-Man. Andrew Garfield will keep Spidey Caucasian, but Glover's still getting some digs in. He opened the new season of "Community" dressed in Spider-Man pajamas. It was more for the Black Spidey movement than for Glover himself.
"It's weird, I feel like a lot of people were connected to that more so than I was which was interesting," Glover said in a conference call today. "It felt like the war veteran who had his leg shot off and then he got a new leg and walks up to the podium and people are teary eyed. And people are like, 'He did it anyway.' I'm like, it's not that big a deal. This happened during the summer, let's make a nod to it. It was fun to do it. Was the costume cool? It was pajamas. Pajamas that were tailored to me."
More after the jump…
Back in August, we reported that Jeffrey Dean Morgan would star in The Courier, a film about a bagman attempting to deliver a mysterious briefcase while crooked cops, gangsters, and federal agents try to jack him. Now we know who will play these shady characters. It's been announced that Mickey Rourke and Til Schweiger have joined the cast. This is fantastic casting. We all know what Mickey Rourke is capable of, and Til Schweiger was a highlight of Inglourious Basterds.
Production begins later this month in New Orleans, but don't tell Jason Statham. If he hears there's a film about an expert bagman going on, he may just assume he's the star. Things could get awkward if he shows up and asks for a call sheet. (The Wrap)
Artist's Rendering of Bradley Cooper as The Flash
Bradley Cooper is busy on the set of The Hangover 2, but that hasn't stopped the Hollywood rumor mill from speculating about his next project. And somehow, this unseen, all-knowing group has determined that Warner Bros. is eyeing Cooper to play Barry Allen. For those of you who lost your virginity before the age of 25, Barry Allen is also known as The Flash.
According to the Silver Age origin story (or should I say, "according to Wikipedia"), the character of The Flash was born when lightning struck a shelf full of chemicals, causing them to explode onto police scientist Barry Allen. Rather than killing Allen, like most chemical explosions would tend to do, the accident gave him the gift of super speed, which he then put to use fighting crime.
A chemist once gave my friend the gift of "super speed," but all he ended up fighting was a plate glass window and some oncoming traffic. He lost. (Latino Review)
I'm not 100% certain that this isn't Jared Leto. Skip to the end to see the final product. (VideoGum)
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Terrible time to pass a kidney stone.
Danny Boyle has confirmed to a friend of DreadCentral that he will in fact direct the next film in the 28 Days Later franchise. There a no details as to what the film will be about, or what the title will be. All anyone knows is that Boyle will return to direct.
After directing the first film in the series, Boyle was credited with reinventing zombies by people who know nothing about zombie movies. What the story is actually about is a rage virus that causes people to run around attacking everyone they see. Just like that Jason guy from "The Hills." Or that episode of "The Smurfs" that I still sometimes have nightmares about. **burns self with cigarette to stop from nodding off**
Fox has picked up 6 episodes of the animated adaptation of 2004's most quoted movie, Napoleon Dynamite. Deadline has the deets:
The original cast of Napoleon Dynamite led by Jon Heder is back to voice the animated series, which follows the misadventures of an awkward high school teenager and his quirky friends as they struggle to navigate life in rural Idaho. The film's writers Jared Hess, who also directed it, and Jerusha Hess wrote the adaptation with The Simpsons veteran Mike Scully.
Seems like the perfect movie to turn animated considering the film itself is insanely over the top. I always understood the llama for a pet and awkward teenage boy desperately in need of psychological counseling, but side ponytails? C'mon, no one wears those anymore!
New photos from the set of David Fincher's The Girl With The Dragon Tattoo reveal Daniel Craig will look like Daniel Craig. Question though, is there a wardrobe stylist on this movie? If so, does she know how to use an iron? Those pants are just…. oh my God. I can't believe he went out in public wearing pants that wrinkled. C'mon, is he playing a journalist or a blogger? Step it up, The Girl With The Dragon Tattoo stylist!! Pants that wrinkled will never earn a nomination in one of those boring Oscar categories. (Just Jared)
Check out a pic of a punked-out Rooney Mara after the jump…
Director: David Fincher
Cast: Daniel Craig, Rooney Mara, Stellan Skarsgard, Christopher Plummer, Robin Wright
Synopsis: A journalist and a computer hacker team up to solve a 40-year-old murder.
Release Date: December 21, 2011
He's honored to even be considered.
Sony has offered the villain role in the Spider-man reboot to Rhys Ifans. You may remember him as the slovenly roommate in Notting Hill, or a lot more things if you're British. No word yet on exactly which villain he'll be playing though. I'm getting a Green Goblin vibe from him, but I suppose he could also be Venom with the right black unitard. If Ifans does in fact play Green Goblin he already has experience creating his own aviation contraptions.
Spidey doesn't stand a chance. (Deadline)
Producers of "The Simpsons" hired British street artist Banksy to direct their opening credits sequence, because after Ke$ha, why the hell not? I don't want to give too much away, but I can say this is the bleakest intro I have ever seen for a cartoon. And, yes, I'm including "The Cleveland Show" in that statement.
Check out the video after the jump to find out how many slave pandas need whipping to bring you the antics of America's favorite family…
Did you catch the premiere of Showtime's new original series "Look?" You might have missed it. It was on Sunday night at midnight (Monday morning if you're being technical, but the point is it's on long after "Dexter.") It's definitely late night viewing because "Look" is more revealing than even the boldest episode of "Californication."
Based on creator Adam Rifkin's own movie by the same name, "Look" tells ensemble drama stories from the point of view of security cameras, cell phone cameras, flipcams and webcams. Characters tweet and text and we view their messages on screen. The characters include adulterous druggie MILF Stella (Claudia Christian), promiscuous teen Hannah (Sharon Hinnendael) and her virginal friend Molly (Ali Cobrin), stripper obsessed Andy (Jordan Belfi), security guards who watch dressing room surveillance footage and many more connected character.
More after the jump…
You might think anything goes with Jackass, but there's actually a complex system in place to ensure the most awesome Jackassery happens safely. Number one rule: You must be sober to dive into poo.
"It's been a rule forever," director Jeff Tremaine said. "You don't do stunts if you've been partying that day. But right after… You can do it hung over but if I know someone's been drinking or doing something else, then they don't shoot that day. I might find out later that Preston did some Xanax the day he did the King Kong bit. He was terrified of heights one day and the next day, 'Oh, no problem. I'll climb up there.' I should've known something's up. Even Steve-O at his worst, I don't think you were ever wasted during a stunt. The guys are never wasted during the stunt. You might get wasted right after. The guys watching it might get wasted but even buzzed."
More insider info after the jump…
A few months back I had the opportunity to visit the set of Nick Swardson's new Comedy Central show "Pretend Time." When I arrived, the comedian was a wearing a crimson red hat and veil, not unlike Lady Gaga. He also donned a police uniform, badge, and department issued handgun. Even though the shoot was taking place in cuckoo bananas Hollywood, something seemed amiss. Turns out Swardson was playing Lady Gaga's brother, Gary Gaga, just a guy trying to keep it real while keeping the streets safe.
After Swardson completed a standard traffic stop in front of confused passersby, I sat down with him to discuss his new sketch show, as well as some upcoming features. Luckily he had taken off the gaudy Gaga attire, so I could concentrate on the task at hand.
I don't know what's happening to our arthouse directors. Last week Aronofsky was linked to Wolverine 2 and now Sony has confirmed that director/Lily Tomlin enemy David O. Russell has been hired to write and direct an adaptation of the videogame "Uncharted: Drake's Fortune." So, you know, I'm all like, 'Whhaaaaaatttttt????!!?????'
Originally, Kyle Ward was hired to write the script but lost the gig due to duties on Hitman 2. Then Sony went to Thomas Dean Donnelly and Joshua Oppenheimer, even though they wrote Sahara and A Sound Of Thunder. Somehow, the gig now belongs to O. Russell. I guess Paul Thomas Anderson (either one in this case) was unavailable.
Fans who are still hoping for a Sin City sequel have new reason to be optimistic. Director Robert Rodriguez has stated that he is ready to start on the film…right after he finishes Spy Kids 4, proving once again that it's always darkest before the dawn.
While Rodriguez is notorious for promising projects that don't materialize, the fact that the director mentioned a specific time frame for the film is a good sign. However, the fact that he's willing to hold off on Sin City 2 so he can go d**k around on another crappy CGI-heavy kids movie is not a good sign. (Cinema Blend)
"Hey! Pick that up, jerk!!"
With Paul Greengrass being "out this bitch," the stage was set for Tony Gilroy to step in and take the helm on the fourth Bourne film. Matt Damon stated he would standby Greengrass, and walk from the project as well. Since that time, everyone was curious what would become of the franchise. Recast? Reboot? A prequelization? Is that a word?
Today, Gilroy answers the burning question. Matt Damon will not appear in the film, nor will his character be recast. The Bourne Legacy will not feature Jason Bourne whatsoever. Rather, a new agent will be introduced in an effort to expand the Bourne universe and conspiracy. So, like Teen Wolf Too? (Hollywood Elsewhere)
Why someone decided to take last week's episode of "$#*! of my Dad Says" and auto-tune it I have no idea. SidTheBillyGoat posted this video on his YouTube page and now I can't get the damn song out of my head. With those Blue Blockers on, Shatner looks freakishly like Biggie Smalls. Enjoy the video while you eat your pancakes and turkey bacon this morning. HOLLA!
Yay, more Mad Max: Fury Road delay news. Just the other day we reported that Charlize Theron might shed her arm for the film, and now it seems production isn't anticipated to begin until February 2012. But how will I quench my insatiable Charlize amputee fetish?!
George Miller is having worse luck with Mad Max than Terry Gilliam is with bringing a Don Quixote story to the screen. Some powerful force does not want these projects seen by the world. I'm aware of the curse on adapting Quixote, but the troubles with Mad Max's production are perplexing. All I can guess is that somewhere Mel Gibson is surrounded by candles and lamb's blood uttering satanic prayers over a picture of Tom Hardy. (/Film)
She's not even cold yet…
Here are your weekend links.
12 Of The Best Local Theaters In America (Moviefone)
The NYC 'Urban Speaker': F**k Da Police! (Asylum)
The 13 Most Evil U.S. Government Experiments On Humans (Ranker)
25 Bizarrely Humiliating Images Of Hitler (HolyTaco)
Dances With Werewolves? Yes, Dances With Werewolves. In 3D. (FilmDrunk)
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Now These Are Some F**kin Life-Threatening Tits! (BarStoolSports)
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Like all great vanguards, Vince Vaughn has come under fire for his radical views. The funniest part of the unfunny trailer for The Dilemma features Vaughn addressing a room with the line, "Electric cars… are gay," and now, a month later, controversy has sparked.
Rumored electric car lover Anderson Cooper went on "Ellen" and flagged the line as offensive. "I was shocked that not only they put it in the movie," Cooper told DeGeneres. "But that they thought that it was okay to put that in a preview for the movie to get people to go and see it." Just like the trailer for Vaughn's Couple's Retreat, the offensive material will be removed. Not to defend Vaughn's fictional choice of words, but I have to agree he has a point. A car you plug into the wall? C'mon. (Deadline)
"Say 'hallo,' to my giant hair!!!"
I hope you're ready to see Al Pacino attempt to act dramatically while wearing a potpourri of silly lady-wigs, because that's what HBO is going to give us. The NY Times reports that Pacino will rant and scream his way through a portrayal of legendary music producer/firearms enthusiast Phil Spector for an HBO biopic written and directed by David Mamet.
This is awesome. Spector is best known lately for his ability to produce dead actresses, rather than his acclaimed music production, but he's lead an intriguing life that not many know about. For instance, his unauthorized biography highlights the time he took a romantic interest in a young La Toya Jackson. He invited her over and she left running and crying through the Hollywood Hills not too long after. Nobody knows what went on in the house. I mean, c'mon. What HASN'T a Jackson seen? If Mamet can crack that nut, we're in for an interesting story.
"Say what?!"
Warner Bros. has scrapped plans to release Harry Potter and the Deathly Hallows: Part 1 in 3D. Break some hearts, THR:
"When the film arrives in theaters on Nov. 19, it will be in 2D, playing both conventional theaters and IMAX, but that "we will not have a completed 3D version of the film within our release date window. Despite everyone's best efforts, we were unable to convert the film in its entirety and meet the highest standards of quality. We do not want to disappoint fans who have long-anticipated the conclusion of this extraordinary journey."
Good riddance. If the film was going to have Clash of the Titans craptastic post 3D then keep that mofo in the second dimension. Releasing Part 2 in 3D will make it all that more memorable and dare I say…special. However Warner Bros, I suggest you reenforce your studio gates. Some irritated muggles might be storming them at any moment.
Sometimes when someone is a really big star on a TV show, you have to wait for them to do a movie so you can talk to them. Nancy Botwin…
Our fears that Alice Eve would never land another movie role again have been waylaid. She's actually starring in the confined space thriller ATM. Originally, it was reported that Adventureland's Margarita Levieva was playing the role but now that appears to have been misinformation. Either that or Margarita suffers from claustrophobia, or co-star Josh Peck. Sounds plausible. He was a child actor after all.
ATM is filming now in Winnipeg with David Brooks directing from a script by Buried's Chris Sparling. ATM's plot came to be when Buried producer Peter Safran essentially asked Sparling, "Hey. Wanna milk this contained thriller sh*t?" Sparling's response, of course, was a resounding "F**k yeah!" (via The Playlist)
I knew it was only a matter of time before The Social Network inspired a copycat film. But I hardly expected said film to be a biopic on Karl Rove with Shia LeBeouf playing the Republican strategist. But like Costco on Acid, Hollywood can be a very strange place.
In the wake of The Social Network's success, the L.A. Times brings word that the new hot biopic circulating in Hollywood is the Wes Jones script for College Republicans, a dramedy about Karl Rove's college bid to become chief campus conservative under the tutelage of Lee Atwater. Among the many young hotties vying to play Rove (only in Hollywood!) is Shia LaBeouf…
Now that I think about it, I can totaly see why this might come together. A lot of people seem to hate Karl Rove, a lot of people seem to hate Shia LeBeouf, and I always have to pretend I know who they both are so I don't look stupid. It's the perfect fit. (Vulture)
We've got word that Ridley Scott's Alien prequel may end up being downright adorable. Early reports that Gemma Arterton would star in the film were shot down, leaving the role wide open for the right starlet. According to Deadline, the director and studio have been meeting with actresses, including Carey Mulligan, and Noomi Rapace.
Rapace is said to have a made "a strong impression." There wasn't any mention of how Mulligan's meeting went, but our inside sources confirmed that Ridley "really liked that little boy."


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YogaWorks 500-Hour Teacher Training, Restorative Yoga Certification with Judith Lasater
nurturing, focused, fun
Yoga keeps me grounded and truthful. The longer I practice, the more fully and courageously I live in my body.
I think it is a profound practice that I want to share with everyone! I am called to teach what I love.
Nature, Visual and performing art, My ongoing anatomy studies, Salted caramel ice cream


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Chariton's Ukrainian community celebrated its's second annual Festival on Saturday, September 17. The weather was cool with scattered showers, but that did not stop the courthouse square from filling up with people. Home cooked Ukrainian food was displayed on a large table including home-cooked traditional perogies, some breads, cabbage rolls, borsch, blintz and a variety of other choices. To wash the food down there was a Ukrainian soft drink known as "Kvass".
Accordians and other musical instruments, native to the Ukrainians, were played giving live music to the crowd. Children and adults were dressed in traditional attire and a speaker shared Ukrainian history.
(Article in the Herald-Patriot, September 22, 2011, was written by Sandra Knebel)


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|Boone Chamber Celebrates Membership with Parade
|Written by Boone Chamber
|Wednesday, 06 June 2012 07:35
The Boone Area Chamber of Commerce is CELEBRATING BUSINESS...and recruiting new members! Toward that end, the chamber will take to the streets on Monday, June 11th, with a parade showing off the colors of business in the High Country. Don't know what that means?
Come to the Membership Parade, downtown Boone, Monday June 11th at 10am and find out. See You there! For more information please call 828-264-2225
|Share This Article:


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PressPublic Group active 2 years, 6 months ago
Producing news and dealing with press inquiries.
New post from Twitter user occupylondon in the group : 2 years, 12 months ago
Hackney Credit Union open day Sat 6th, 12 noon. See socially useful banking at 225 Mare St. http://t.co/PnYOXlq4 @moveyourmoneyuk #


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Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study will be to demonstrate the safety, tolerability, and efficacy of arimoclomol in subjects with SOD1 positive familial Amyotrophic Lateral Sclerosis (ALS). This type of ALS is HEREDITARY (runs in families), and at least one other person in the family must have had ALS.
Study hypotheses: Arimoclomol, taken at a dose of 200 mg three times daily will improve survival as defined by time to death, tracheostomy or permanent assisted ventilation. In addition, it will be safe and well tolerated in subjects with SOD1 positive familial ALS.
Funding Source - FDA-OOPD
Amyotrophic Lateral Sclerosis 1
Acquired Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Drug: Arimoclomol
Phase 2
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
|Official Title:
|Phase II/III Randomized, Placebo-Controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis (ALS)
- Time to death, tracheostomy or permanent assisted ventilation will be the primary outcome measure. [ Time Frame: 12 months ] [ Designated as safety issue: No ]
- Rate of decline of ALSFRS-R (ALS functional rating scale-revised) over a period of up to 12 months. [ Time Frame: 12 months ] [ Designated as safety issue: No ]
- Disease progression as measured by the rate of decline of FEV6. [ Time Frame: 12 months ] [ Designated as safety issue: No ]
- Safety and tolerability of arimoclomol will be evaluated by using vital signs and weight, clinical laboratory measures, physical examination, report of adverse events, and the proportion of subjects completing the study on assigned treatment. [ Time Frame: 12 months ] [ Designated as safety issue: Yes ]
|Study Start Date:
|January 2009
|Estimated Study Completion Date:
|December 2016
|Estimated Primary Completion Date:
|December 2016 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Placebo Comparator: 1
Drug: Arimoclomol
Drug: Placebo capsules given three times per day
Drug: Arimoclomol capsules given three times per day
Other Name: Arimoclomol (BRX-345)
|Active Comparator: 2
Drug: Arimoclomol
Drug: Placebo capsules given three times per day
Drug: Arimoclomol capsules given three times per day
Other Name: Arimoclomol (BRX-345)
Detailed Description:
Using a seamless, adaptive, phase II/III design, the investigators will determine the safety and efficacy of arimoclomol in patients with SOD1 positive familial ALS. Both stage-1 and stage-2 are randomized, double-blind and placebo-controlled in a population of patients with rapidly progressive SOD1 positive familial ALS. Patients with ALS, a history of a relative affected with ALS (i.e. familial ALS) and the presence of a demonstrable mutation in the SOD1 gene that is known to be associated with rapidly progressive disease, will be eligible for inclusion in this study. Potentially eligible subjects will undergo screening via telephone and, if necessary, review of outside medical records. The intervention will continue for up to 12 months. In the event that a participant reaches a study endpoint (e.g. tracheostomy or permanently assisted ventilation) study drug will be terminated. Subjects who meet all eligibility criteria will travel a study site for final eligibility determination, baseline evaluation and will then be randomized 1:1 to receive either placebo or arimoclomol at a dose of 200 mg t.i.d. Participants will then be evaluated again in person at a study site at Month-2. Subsequent telephonic evaluations at Month-3, -4, -5, -6, -8, and -10 will be performed in participants' homes. Safety and tolerability evaluations will be performed at each of these visits. Collection of blood samples for safety laboratory analyses and measurement of blood pressure, heart rate, respiratory rate, temperature and weight will be performed at Months -1, -3, -5, -6, -8, and -10 in the participant's home by a representative of a medical monitoring company. A study coordinator may perform an in-person visit at Month-12, or this visit may occur telephonically. A final evaluation will be performed via telephone at Month -13 (30 days after the last dose of study medication).
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Type of ALS that is hereditary (runs in families) only.
- El Escorial criteria for familial ALS and a family history of a pathogenic mutation in a gene known to be associated with ALS, such as the SOD1 gene.
- Willingness to undergo genetic testing and to learn the results.
- Demonstrable mutation in the SOD1 gene that is reported to be associated with a rapid rate of disease progression (i.e. A4V, A4T, C6F, C6G, V7E, L8Q, G10V, G41S, H43R, H48Q, D90V, G93A, D101H, D101Y, L106V, I112M, I112T, R115G, L126X, G127X, A145T, V148G, V148I) or possibly associated with rapidly progressive disease (E21G, G37R, L38V, D76Y, L84F, L84V, N86S, D90A het, G93R, I104F, I113T, L144F, L144S).
- Age 18 years or older; male or female.
- Capable of providing informed consent and complying with trial procedures.
- Diagnosis within less than 9 months of the anticipated date of the baseline visit AND study participants' subjective evaluation that they expect their physical condition to permit travel to the study site for both the baseline and 2-month study visits.
- Women must not be able to become pregnant (e.g. post menopausal for at least one year, surgically sterile, or practicing adequate birth control methods) for the duration of the study. Adequate contraception includes: oral contraception, implanted contraception, intrauterine device in place for at least 3 months, or barrier method in conjunction with spermicide.
- Women of childbearing potential must have a negative pregnancy test at screening visit and be non-lactating.
- Willing to remain on a stable dose of Riluzole or to remain off Riluzole for the duration of the trial.
- Identifiable local medical doctor to assist with urgent care of any medical complications that may arise.
- Absence of any of the exclusion criteria.
Exclusion Criteria:
- History of known sensitivity or intolerability to Arimoclomol or to any other related compound.
- Exposure to any investigational drug within 30 days of the screening visit.
Presence of any of the following clinical conditions:
- Substance abuse within the past year.
- Unstable cardiac, pulmonary, renal, hepatic, endocrine, hematologic, or active infectious disease.
- AIDS or AIDS-related complex.
- Unstable psychiatric illness defined as psychosis (hallucinations or delusions), untreated major depression within 90 days of the screening visit.
- Positive pregnancy test at screening visit.
Screening laboratory values:
- Creatinine greater than 1.5.
- Alanine aminotransferase (ALT) or Aspartate aminotransferase (AST). greater than 3.0 times the upper limit of normal.
- Total bilirubin greater than 2.0 times the upper limit of normal.
- White blood cell (WBC) count less than 3,500/mm3.
- Platelet concentration less than 100,000/ul.
- Hematocrit level less than 33 for female or less than 35 for male.
- Female patients who are breast-feeding.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00706147
|United States, Florida
|University of Miami Miller School of Medicine
|Miami, Florida, United States, 33136
|United States, Massachusetts
|Massachusetts General Hospital
|Boston, Massachusetts, United States, 02114
|Principal Investigator:
|Michael Benatar, MBChB, DPhil
|University of Miami
|Principal Investigator:
|Merit Cudkowicz, MD, MSc
|Massachusetts General Hospital
No publications provided
|Responsible Party:
|Michael Benatar, Associate Professor, Department of Neurology, University of Miami
|ClinicalTrials.gov Identifier:
|NCT00706147 History of Changes
|Other Study ID Numbers:
|Arimoclomol in SOD1 fALS, 3517
|Study First Received:
|June 24, 2008
|Last Updated:
|February 18, 2015
|Health Authority:
|United States: Food and Drug Administration
Keywords provided by University of Miami:
Amyotrophic Lateral Sclerosis (ALS)
Hereditary ALS
Hereditary neurological disease
Lou Gehrig's Disease
Motor Neuron Disease
Familial ALS
Neuromuscular disease
SOD1 mutation
Superoxide dismutase
SOD1 positive ALS
inherited ALS
Additional relevant MeSH terms:
Amyotrophic Lateral Sclerosis
Motor Neuron Disease
Central Nervous System Diseases
Metabolic Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neuromuscular Diseases
Pathologic Processes
Proteostasis Deficiencies
Spinal Cord Diseases
TDP-43 Proteinopathies
ClinicalTrials.gov processed this record on October 13, 2015


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NOW Foods
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Oat Bran is an excellent source of both soluble and insoluble fiber. Oat Bran can be taken directly raw, as a hot cereal, or used in baking muffins and other foods. To use as a hot cereal, simmer 2/3 cup Oat Bran in 2 cups water for 2 minutes, while stirring. Add salt, raisins or flavors to suit taste. Serves two Optional: Add 1 tsp vegetable oil for added smoothness.
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First Warmth Of Spring
Anna Gillespie
Bronze, Found Steel Pedal
23cm (h) x 12cm (w) x 12cm (d)
Please make an enquiry for more information about this artwork.
Artist Profile
Anna Gillespie is a contemporary figurative sculptor whose work continues to increase in popularity.
Last year her sculpture was shown at The RHS Chelsea Flower Show in a Gold Awarded garden with a later commission for Glastonbury Festival. Anna was also recently selected to produce a large scale public sculpture in Kazakhstan.
Click to Read an In-depth Article
Her sculptures express complex human emotions as well as her responses to environmental issues. The work varies in scale from life-sized, life-like masking tape figures presented in groups to form installations, to more intimate pieces cast in bronze, as well as drawings and prints. This exhibition of her more domestic scale work includes both very recent pieces as well as selected works from the last five years.
Anna Gillespie's emerging consciousness of the seasonally and fragility of the world around her has led her to develop sculptures in more natural materials such as acorns and bark. She has also taken natural objects such as delicate leaves and seed pods into the print room. The resulting work is not a Romantic depiction of the natural world but rather continues the theme of her earlier work, challenging the emotions and conveying a politically charged message. Combining these natural materials with found objects and the sculpted human form she expresses her growing concerns about the environment. Anna Gillespie believes that art has the potential to engage people at a human level with the environmental crisis we face.
The work appears to emerge from an almost subliminal level - connections and ideas within it have poetic symbolism, resonance and power; conceptual connections are a valued part of the process but are not allowed to dominate. Through using the human form Anna Giilespie feels a connection with other artists throughout history - believing that it is a fundamental human impulse to use form to depict humanity and our relationship with each other and the natural world. Sensing that deep knowledge is stored within the body, and acknowledging the spark ignited by recognition of the human form, she believes that figurative work may offer a challenge the disembodied nature of our society and connect us more deeply with the body of the planet we inhabit.


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Is it important that the naval burial of Osama Bin Laden on the USS Carl Vinson was done according to Islamic traditions? I see both sides of the argument, but am tiring of seeing the according to Islamic tradition in every article on the subject.
In a semi-related point, when I was stationed in Bahrain, I lived around the corner from Coffee Bean. I used to go there after work to unwind and grab a cup of tea. They labeled their garbage can: Trash Bin. And I thought how easy it would be to add a Laden after the Bin. I did not, of course. I am a law-abiding Sailor, with a nagging, constant worry hovering over me about both the brig and jail. Hence, no action. Should you be stationed out in pleasant 5th Fleet, resist the temptation. . .


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In Theatres: Clive Owen and Juliette Binoche in 'Words and Pictures'
Clive Owen and Juliette Binoche go head-to-head, but probably fall in love, in Words and Pictures, a romantic comedy in theatres this weekend.
Owen and Binoche play professors of both literature and visual art, and they compete to inspire their students and prove which medium is, well, the best. Sort of like a Firemen vs Policemen thing.
"Clive Owen's Jack is a grizzled and disgruntled star poet whose pen is now dry but whose cup never is," writes Peter Holland, film critic for the Toronto Star. "His drinking and subsequent outbursts have him banned from his favourite pub and on waivers at Croydon, the New England prep school that charitably still employs him.
"She's also an acclaimed artist, a painter of bold and colourful abstract canvases," Holland writes of Binoche's character. "But arthritis has robbed her of much of her mobility and all of her smile. She, too, is tired of her situation, but not so fatigued that she won't engage Jack in argument."
Kettle, meet boil.
Also in theatres, Eric Bana seeks out the demonic in Deliver Us From Evil, a film based off a book by a real-life New York City detective who traded in the badge for a career chasing the paranormal.
Olivia Munn, Edgar Ramirez, and Joel McHale also star.
Finally, Gerontophilia is in theatres - the story of a young man who has romantic affections for the elderly and develops a close bond with a patient named Melvyn Peabody.


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Available mid-May 2013The RA-1570 combines proven analog design with sophisticated digital circuits to bring all of your sources to life with amazing fidelity. The integrated amplifier features a front panel USB input, making it easy to connect a wide variety of music storage devices including iPods®, iPhones®, and iPads® directly, or via the supplied Bluetooth dongle. Rotel has not forgotten analog fans of vinyl either by including a high performance moving magnet phono input. Meanwhile a highly regulated power supply with custom-designed toroidal transformer provides high current capability to a Class AB output stage. The amplifier design uses multiple discrete output devices to ensure precise reproduction of all signals with virtually any loudspeaker.
Trademark Acknowledgements
Apple, iPod, iPhone and iPad are trademarks of Apple Inc., registered in the US and other countries.TOSLINK is a trademark of Toshiba Corp. Copyright © Rotel. E&OE.


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ABM Parking Services - Lower Level
1 S. Lower Wacker Dr., Chicago, IL 60606
Parking: Tue, Oct 13 at 11:00pm to Wed, Oct 14, 2015 at 2:00am
ParkWhiz worry-free cancellation (cancel anytime up to your start time)
Special online rate!
Amenities Included:
Upon arrival, scan your ParkWhiz parking pass on the red light scanner and you will be let through. Even if the sign at the lot says it is full, they still save spaces for ParkWhiz customers. Upon exit, scan the pass on the red light scanner and you will be let out.
If you arrive before your arrival time, you may need to pay an additional fee. This location does not allow in and out privileges.
Please pay close attention to the "How To Find It" instructions. This parking location is on Lower Wacker Dr.
Perfect for visiting the Civic Opera House. Finding this underground garage can be tricky but the location is excellent.
Managed by ABM Parking Services (Chicago). This location is a commercial parking garage.
Nearby destinations: Lyric Opera of Chicago, Cadillac Palace Theatre, McDermott, Will & Emery, Union Station, Ogilvie Transportation Center.
This garage is only accessible when starting at W Harrison St & S Wacker Dr.
At the above intersection, follow signage for Lower Wacker Dr and drive northbound for four blocks.
Immediately after passing a blue pillar for Exit 233 there will be an option to get in the rightmost lane with signage pointing toward One South Wacker Parking.
Once in this right service lane, continue forward a few blocks till you come across a yellow pillar with OSW written on it.
Follow the arrows from this pillar to the entrance gate of the garage.


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I learned how to do a blindhem stitch on the machine, using this tutorial on youtube. It may take a few more attempts to perfect this skill, but it wasn't hard once the light went off about how the fabric was to be folded.
Here is a close-up of the fabric, which I adore, though it tends to hold a wrinkle:
I am so obessed with sheath dresses for work. Seriously, they could be the only thing I sew.
Are you tired of this pattern yet? I don't have any immediate versions planned, though I'm sure I will sew a few more of these in the future.


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Like many people here I experienced pretty intense pain with Olympus Test E. The first pin swelled really bad to the point where my pants fit tighter. I had a golf ball implant in my glute. The second pin swelled and hurt like heck too. The next several pins were getting better, but the PIP still ruined my lower body work.
I bought 6 vials of Test E during the sale. I was thinking of tossing it, but I salvaged it in a simple manner. You are going to have to cut it with gear that you don't experience PIP with. Surprisingly, this worked for me.
Now I just take .5cc of Olympus Test E with .5cc of another's Test E and problem solved. No PIP whatsoever now.
Don't toss out the gear! It works, it just hurts.


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Buzz: The Chance Rick Nash Holds Out In Columbus
In the Columbus Dispatch, Aaron Portzline writes that Scott Howson has not come close to trading Rick Nash and there is a chance that Nash will still be part of the organization when training camp starts.
Portzline writes that Nash could hold out during training camp, a move that would cost him over $27,000 per day, and that he has sympathy from Keith Primeau who held out in Detroit in 1996.
Primeau said, "You think you're going to play forever, and then you look back and it's been 10 years. Your career is half over. Every year that goes by without the playoffs is another missed opportunity, and you get to a point in your career where you just can't sign years off anymore."
Portzline adds that a holdout during training camp would be a move to keep him healthy and not risk injury that could further delay a trade.


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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
State lawmakers representing St. Lawrence County are at odds over a Senate proposal to use proceeds from the sale of unused St. Lawrence River Valley Redevelopment Agency power for economic development projects within a 40-mile radius of Massenas hydrodam.
The proposal, championed by the River Agency and backed by state Sens. Joseph A. Griffo, R-Rome, and Patricia A. Ritchie, R-Heuvelton, needs more work before it can get the support of Assemblywoman Addie J. Russell, D-Theresa, she said Friday. She said the Senates plan is flawed because it could allow communities outside of St. Lawrence County to benefit.
River Agency officials since the organizations start in 2008 have sought to capitalize on 20 megawatts of low-cost power that had been promised but not awarded until last year by the New York Power Authority for economic development. Agency officials have planned to sell any power not allocated to aid new and expanding businesses and keep the profits to fuel the River Agencys community development fund and other initiatives to spur growth.
Previous attempts to gain the ability to sell the power through its agreements with NYPA failed to garner the support of both former Gov. David A. Paterson and Gov. Andrew M. Cuomo. The River Agency is currently seeking state legislation to make it happen.
A proposal floated in the Senate last week that could become part of that chambers 2013-2014 budget bill calls for proceeds from the sale of unallocated power to be managed by a five-member board appointed by the governor and for that money to fund initiatives within a 40-mile radius of the St. Lawrence-FDR hydropower project in Massena. Under the Senates proposal, 15 percent of the money must be used for energy-related projects and initiatives. The rest can be used to help private and nonprofit businesses upgrade buildings and equipment, acquire land and undertake other growth-related activities, and help support tourism and marketing initiatives. Retail endeavors are excluded, as are residential developments, gambling, sports and hospitality businesses, and government lobbying and election activities.
Mr. Griffo said Friday that north country senators are not willing to bend on the proposal because it makes the most sense. Its reasonable based on what we want.
He said there has been some resistance from Mr. Cuomos office, and he has gotten conflicting information about whether the Assembly will support it.
He said if the proposal is ultimately not included in the Senates budget bill, it will be dealt with as separate legislation.
Its still being discussed, he said.
Asked what objections Mr. Cuomo might have, governors office spokeswoman Olympia Sonnier said only that The governors administration was proud to work with NYPA to add 20 megawatts of power to be used for economic development in north country, and we will continue to engage with the North Country Regional Economic Development Council and elected officials to look for additional opportunities for growth.
Mrs. Russell said her objection is simple. Language stating the proceeds will benefit those within a 40-mile radius of the Massena hydro facility should be changed, Mrs. Russell said. She said since the power was intended to help St. Lawrence County, thats where its proceeds should stay. A 40-mile radius would include part of Franklin County.
I think we are all in agreement that it should be for the benefit of St. Lawrence County, and not go beyond those boundaries, she said.
The geographic radius and the creation of a governing board, dubbed the Northern New York Power Proceeds Allocation Board, were included in the proposal to mimic a similar agreement to use proceeds from the sale of unallocated power from the Niagara Power Project in Western New York, Mrs. Ritchie said.
She said Mr. Cuomos office insisted that the proposal closely mirror the Western New York framework. The Niagara agreement covers a 30-mile radius from the Niagara project, but that number would not work for St. Lawrence County, she said.
To include the entire town of Lisbon, which is one of the towns included on the River Agency, we had to bump it up to 40 miles, Mrs. Ritchie said. Otherwise only half the town of Lisbon would be included.
She said she has also been informed that Assembly support may hinge on whether Jefferson County can also benefit from selling the power.
My job is to advocate for those who have been involved in the negotiations and the communities they are representing on the River Agency. They dont want to agree to three counties, she said.
She would be open to language restricting the 40-mile radius to inside St. Lawrence Countys boundaries,
If the assemblywoman can get the governor to buy into language saying it will benefit St. Lawrence County only, I certainly would be supportive of that, Mrs. Ritchie said.
Mrs. Russell said she doubts all sides can reach an agreeable solution before the states budget is passed. The budget is due April 1.
The Senate including it in its budget has gotten more focus from the administration looking at this issue, she said. It likely would become a priority in the next several weeks.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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The Ascend 47 striped long sleeve tee has yarn-dyed stripes, LRG embroidery at the left chest, and woven LRG labels at the collar and bottom right hem. Also featuring a henley-style placket with two buttons and contrast-colored stitching, this super soft T-shirt is just the thing to take your fall wardrobe to the next level. Keep it up, and you'll always be at the peak of the style hierarchy.
- 60% Cotton/40% Polyester
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- Woven LRG tags at collar and bottom right hem
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500-Hour Yoga Alliance Certification, YogaWorks Certification
flowing, fun, restorative
One day I hope to unify and bring peace to the five sheaths of my body: the anatomical, the physiological, the mental, the intellectual and the spiritual (BKS). I would also like to lose my love handles.
I hope to better understand the shape and form of the body, mind and spirit and refine my abilities to integrate the knowledge of my teachers past and present into my students' lives. I also teach to feed an out of control ego and my need for validation on a daily basis.
"I have news for you — there are people who get up in the morning and cross a room and open a window to let the sweet breeze in and let it touch them all over their faces and bodies." (Tony Hoagland)


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No one hyped for #Launchcraze ?
Last edited by Otorinth; 03-25-2014 at 12:54 PM.
Bless the retweet gems. Got the Sun Wukong Sith skin
Currently playing: FFXIV (Elucifer Arclight, Leviathan server), LoL (Trash Tier Waifu, NA server), SMITE (Zacewing)
I got arachne's skin+voice pack, she's top 3 favorite Gods for me tbh.
The young Zeus skin (forget its actual name lol) + his voicepack for me.
»Games & IGN«Wurm Online » LeviathanFFTA2»Last updated May 31 2010«
Been getting in to playing Change in arena (when I'm not having to tank on Ymir) and she is crazy with max CDR.
I've been practicing some ADC lately with Apollo. Gotta start improving my accuracy.
For new players I recommend starting with easy gods.
Start with Ymir first, he is a great support. Support (guardians) usually have the least skill requirement. They are very durable so you will not be punished too much until you learn to juke and have good positioning.
ADCs are the last gods you should play because they require the most skill.
Apollo is also a great pick for people wanting to play hunter due to the stun + protections from serenade and the moves makes a great escape tool, plus his ultimate gives him a global presence which is incredibly useful for things such as split pushing.
Last edited by olaph; 04-05-2014 at 04:04 AM.


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Glenn R. Cunningham
Glenn R. Cunningham,70, of Heroux Blvd., died Sunday in the St. Antoine Residence, North Smithfield. He was the beloved husband of Priscilla (Lugn) Cunningham.
Born in Pawtucket he was the son of the late Samuel and Lenna (Atwell) Cunningham. He was raised in Nova Scotia returning to Cumberland at the age of six. and resided in Cumberland for the rest of his life.
Mr. Cunningham was a Cumberland High School Graduate and had earned his Associate Degree from Dean Junior College and his Bachelor Degree in Music from Acadia University, Wofveille, Nova Scotia. He earned his Masters Degree in Guidance and Counseling from Providence College.
He was a retired school teacher for 33 years with the Pawtucket School Department. Mr.Cunningham was also an organist and choir director at various area churches for 55 years, most recently at the Candleberry Chapel, So. Main St., Attleboro. Mr. Cunningham was also an avid dog lover.
Besides his wife he leaves one daughter, Dawn A. Froonjian of Stafford Springs, CT. One son, Shawn G. Cunningham of Attleboro. He was the half brother of William D. Cunningham of Oregon and brother of the late Donna Brackett and Joanne Cunningham.
A celebration of his life will be held Saturday with services at 10 a.m. in the J. J. Duffy Funeral Home, 757 Mendon Rd. Rt. 122, Cumberland. Burial will be private. Relatives and friends are kindly invited. Calling hours Friday from 4-8 PM. In lieu of flowers donations may be made to Candleberry Chaple, 381 South Main St., Attleboro, MA 02703. Directions/guestbook:
|Mr C.jpg [1]
[1] http://www.pawtuckettimes.com/sites/default/files/Mr C.jpg


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By RICHARD SHAWSun Advocate publisher
It seems rural legislators across the state of Utah have the same major concerns. These issues include water, land use and education, among others.
And of course the state budget - constrained by a sagging economy - is included with those concerns, as well.
These and other topics were apparent during the first- ever rural news conference held at the Utah State Capitol building on Thursday, March 4 as 13 state senators and representatives availed themselves to the rural newspaper media at the Utah State House of Representatives.
While each had their emphasis' on various issues in their respective districts, it was obvious they were together on many concerns facing country folk in the Beehive State.
"Small newspapers are the conduit to the people we serve," said State Sen. Kevin Van Tassell (R-26). "They provide correct information for their readership."
Each of the representatives present spoke, providing their take on this year's legislative session and commenting on recent events, both within the state and those that concern Utahns nationally.
"We are losing jobs and school trust lands money because of the power the federal government is asserting," said Rep. Kraig Powell (R-54). "With the public lands bill we are working on, Utah will be in the limelight because we will be one of the first to do this kind of thing."
There are presently three bills in progress in the legislature that propose to give the state eminent domain authority over certain federal lands and to fund the ensuing court battles to defend those bills that legislators say will surely come.
All three local representatives for Carbon County were present at the press conference.
Sen. David Hinkins (R-27) talked about a bill that he had sponsored and that passed concerning oil and gas money in conjunction with the Navajo Reservation in San Juan County.
"We just need to be sure that money benefits the people that live on the reservation in Utah and doesn't go to the Arizona side," he said.
He also expressed his pleasure seeing the Utah State-College of Eastern Utah merger take place, a vote that had only been completed a couple of hours before he spoke to the rural media.
"I think this is a great opportunity for higher education in Price and Blanding, and I think we will see more grant money coming our way because of it too."
Representative Christine Watkins (D-69) said that she had been delighted to sponsor the Italian-American legislation which recoginizes the contribution those immigrants provided to Utah and, of course, to the "Carbon County area."
"I am the only 'D' (Democrat) in the room," she joked as she talked about legislation she has been involved in which also included education bills and water legislation.
Rep. Patrick Painter (R-67), who represents the western third of Carbon County talked about bills he has been working on including land issue bills and a constitutional amendment which would take away unfair taxation on water delivery systems.
Because the bill he has been working on is a constitutional change it will be on the ballot for a public vote in November.
Painter and Watkins also lauded the USU-CEU merger as a good thing for the area.
"I think the equation on this merger is that one plus one will equal three with this change," stated Painter.
Both Sen. Dennis Stowell (R-28) and Rep. Evan Vickers (R-72) pointed out that the composition of the Utah State Board of Regents' (governing board over higher education in the state) membership had been much more slanted toward populated areas than it should have been. They are both working on a bill to change the makeup so the board is more equitable.
Stowell also had an interesting take on the budgeting process and the cuts that the state has been and is faced with.
"While we are facing some bigger cuts this year, I have talked to people about the cuts we made last year and most say they haven't seen a change in government services since those cuts came into affect," he said. "I think that shows we are just getting more efficient in state government."
Rep. Ronda Rudd Menlove (R-1) told about efforts to get state healthcare reform through the legislature. She said that electronic records and record access are big issues and that she believed health care reform moves that the state is trying to make should be attempted, and that the federal government should let the state try to make its way through the problems.
She also pointed out that budget cuts, which will affect all aspects of life in Utah, can be made up in many ways by community action.
"The budget cuts that are coming will mean less government services particularly in the areas of aging, disability, etc." she stated. "People need to reach out to neighbors and their community to help. The state government will no longer be able to provide many of the services that have been available."
Another issue that came up was that often it seems rural Utah and its representatives are divided and don't present a unified front that is needed to influence things on the hill. The rural caucus (state senators and representatives with rural constituencies) have been meeting for years and during each session get together every week to discuss issues and listen to parties who have concerns about rural problems.
"Changes are coming to rural Utah that in the next decade will define how the rural part of the state will look for a long time," said Sen. Ralph Okerlund (R-24).
"I assure you that the rural legislators - through the caucus - have become a cohesive force that can influence policy and legislation. We were recently called in and asked about our take on some issues, because the legislatures leadership knows we need to be heard."


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Football Focus Podcast: Week Eight
Brought to you by Tommy's Pizza Too
Week eight of the podcast highlights another round of big games in Division I, including Portsmouth vs. Cranston East, and a Division II-A battle for second place between Warwick Vets and Johnston. Click the link below to listen!
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The showjumping indoor season is approaching its climax. The best riders of the last six months will take part in a four-day Final, held in Hertogenbosch, the Netherlands this weekend. Edwina Tops-Alexander, a long-time friend of Jaeger-LeCoultre, has had a very successful winter, obtaining the third rank in Zurich, and the second rank in Bordeaux, amongst other Tournaments.
Her overall 11th position in the Western-European League allows her to take part in her fourth final.
Edwina's extreme fighting spirit and high precision skills will certainly be crucial in the quest for the title, while her key objective for the season remains the Olympic Games. Jaeger-LeCoultre wishes Edwina the best of good luck for this Final.


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Reviewer: Walter Sall, MD
Last Modified: May 15, 2005
Presenter: E.E.Vokes
Presenter's Affiliation: National Cancer Institute
Type of Session: Scientific
Materials and Methods
Author's Conclusions
Clinical/Scientific Implications
The combination of BEV and erlotinib gives another potential option for the treatment of this difficult clinical problem. Further studies in the phase III setting of BEV alone vs erlotinib alone vs the combination may be warranted in order to determine whether the use of both agents together is warranted. Care certainly needs to be taken in selecting potential patients for this regimen as the risk of hemmorhage may be increased. For the moment, this combination therapy must still be considered investigational and only offered in clinical trials.