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Bug Shield Cargo Pant (Men's) (out-of-stock)
Out of Stock Product Number: 29604
The men's Columbia Bug Sheild Cargo Pant delivers an amazing protective package to block bugs, sun and unwanted moisture. Quick-drying Omni-Wick? technology keeps you cool and comfortable by whisking moisture quickly away from your skin. Insect Blocker? will keep you bug-free, reducing the need for stinky sprays. Gusset detail gives you great range of motion and the exterior adjustable waistband let's you customize things for a "just right" fit. Multi-functional pockets store small tools, gear, snacks, personal items and just about anything you'll need to have close at hand. Stow valuables and keys in the zip-closed security pocket for extra peace of mind.
* This product does not qualify for shipping to all countries.
- Fabric: 100% nylon Bug Shield minim rip
- Insect Blocker
- Omni-Shade? UPF 30 sun protection
- Omni-Wick
- Classic fit
- Gusset detail
- Partial elastic at waist
- Hook and loop closure
- Zip-closed security pocket
- Hand pockets
- Mesh pocket bags
- Inseam: 30", 32", 34"
- Imported
Gender: Men's
Material: Fabric: 100% nylon Bug Shield minim rip
Fit: Classic fit
Season: S12
Vendor ProductId: AM8014
Review ProductId: 29604


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Somali pirates on the Indian Ocean hijack the cargo ship MV Rozen while it is heading for harbor. Among the men
on board are the ship's cook Mikkel and the engineer Jan. They, along with the rest of the men on board, are taken
hostage in an unsettling game of life and death. With the demand for a ransom of millions of dollars, a psychological drama unfolds between the CEO of the shipping company and the Somali pirates. (103 minutes)
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Approaches to Teaching Narrative of the Life of Frederick Douglass
Related Readings
Audiovisual Materials
Cultural Authority and the Teaching of the Slave Narrative
Personal Places: Slavery and Mission in Graduate Seminars
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Framing the Slave Narrative / Framing Discussion
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Douglass's Narrative in Historical Context
Douglass's "Perplexing Difficulty"
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Portrait of the Artist as a Young Slave: Douglass's Frontispiece Engravings
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Shattering Kidnapper's Heavenly Union: Interargumentation in Douglass's Oratory and Narrative
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Comparative and Intertextual Approaches to the Narrative
A Labor Studies Approach to Douglass's Narrative
Laura Hapke
"Trust No Man!" But What about a Woman? Ellen Craft and a Genealogical Model for Teaching Douglass's Narrative
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Incidents in the Life of Frederick Douglass
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Qualified Knowledge: Douglass and Harriet Jacobs
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Douglass's Narrative in Introductory Courses
Teaching Douglass's Narrative in an Introductory Humanities Course
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Teaching Douglass's Narrative in the World Literature Survey
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Teaching Douglass's Narrative in the United States Literature Survey
Bruce Mills
Works Cited
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Feb 5, 2009
|Filing date
|Sep 23, 2008
|Priority date
|Aug 30, 2002
|Also published as
|Publication number
|Janel Lanphere, Erin McKenna, Wendy Naimark, Marcia Buiser, Stephan Mangin
|Original Assignee
|Boston Scientific Scimed, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Classifications (40), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
The following is a continuation-in-part of [Attorney Docket No. 01194/442001] U.S. Ser. No. ______, filed Aug. 9, 2002, which is a continuation-in-part of U.S. Ser. No. 10/109,996, filed Mar. 29, 2002, the entire contents of both of which are hereby incorporated by reference.
This invention relates to a drug delivery particle.
Therapeutic agents can be delivered systemically, for example, by injection through the vascular system or oral ingestion, or they can be applied directly to a site where treatment is desired. It is also often desirable that the therapeutic agent be delivered at desired dosages for an extended period of time.
In a first aspect, the invention features a drug delivery device which includes a substantially spherical polymer particle having an internal reservoir region including relatively large pores containing therapeutic agent and a metering region substantially surrounding the reservoir region and having fewer relatively large pores.
In another aspect, the invention features a method of manufacturing a drug delivery particle by generating drops. For example, the method can include generating drops of a base polymer and a gelling compound, and combining the particles with a therapeutic agent.
In another aspect, the invention features a method of delivering a therapeutic agent to a patient. The method includes administering to a patient a substantially spherical polymer particle. The particle includes polyvinyl alcohol, and has an interior region having relatively large pores, a surface region having fewer relatively large pores, and a therapeutic agent carried by the particle.
Embodiments may include one or more of the following. The particle comprises PVA. The PVA is 1,3 diol acetalized. The polymer is modified by graft polymerization. The particle includes a polysaccharide. The polysaccharide is alginate. The particle has a coating of polymer. The coating is erodable. The coating covers a drug disposed on the surface of the particle. The therapeutic agent is effective for treatment of cancer. The particle has a sphericity of about 90% or more. The particle has a diameter of about 1 cm or less. The device is a collection of particles.
Embodiments may also include one or more of the following. The method includes reacting the base polymer and removing the gelling compound. The method includes drying the particle and exposing the dried particle to therapeutic agent. The method includes combining therapeutic agent prior to generating said drops. The gelling compound is a polysaccharide. The gelling compound is alginate. The method includes contacting the drops with a gelling agent. The method the gelling agent is a divalent agent. The base polymer is PVA. The method includes reacting the PVA by acetalization. The PVA has a molecular weight of about 75,000 g/mole or greater. The method includes modifying the viscosity of the base polymer and gelling compound prior to forming said drops. The method includes modifying the viscosity by heating. The method includes forming said drops by vibratory nebulization.
Embodiments may also include one or more of the following. The administration is by percutaneous injection. The administration is by a catheter. The therapeutic agent is effective treatment of uterine fibroids. Particles are delivered directly into a tissue mass. Particles are delivered through a body lumen, e.g., a vascular lumen. The particles can be used in embolic applications.
Embodiment may include one or more of the following advantages. A sustained, controlled-dosage release of therapeutic agents can be effected by a substantially spherical agent-containing particle that includes a reservoir region in its interior and a metering region surrounding the reservoir region which controls the release of the agent from the particle.
Other features, objects and advantages follow. For example, features of the particles, including sizes, pore profiles, compressibility, spherosicity, and composition and the methods for making and administering, follow and can be found in U.S. Ser. No. ______ [01194/442001].
Referring to
Referring particularly to
The particles are substantially formed of a highly water-insoluble, high molecular weight polymer. As will be discussed further below, a preferred polymer is high molecular weight polyvinyl alcohol (PVA) that has been acetalized. Preferably, the embolic particles are substantially pure intrachain 1,3 acetalized PVA and substantially free of animal derived residue such as collagen. In embodiments, the particles include a minor amount, e.g. less than about 0.2 weight %, of alginate or another polysaccharide or gelling material. The particle may also include an optional coating 33. The coating erodes in the body, e.g. on contact with body fluid, as will be discussed below.
Referring to
In embodiments, the small pore region near the periphery of the embolic particle is relatively stiff and incompressible, which enhances resistance to shear forces and abrasion. In addition, the variable pore size profile produces a symmetric compressibility and, it is believed, a compressibility profile such that the particles are relatively easily compressed from a maximum, at rest diameter to a smaller, compressed first diameter but compression to even smaller diameter requires substantially greater force. A variable compressibility profile is believed to be due to the presence of a relative weak, collapsible inter-pore wall structure in the center region where the pores are large, and a stiffer inter-pore wall structure near the surface of the particle, where the pores are more numerous and relatively small. The variable pore size profile also is believed to enhance elastic recovery after compression. The pore structure also influences the density of the embolic particles and the rate of therapeutic agent and body fluid uptake.
The particles can be delivered through a syringe or a catheter. The size of the lumen of the syringe or the catheter can be larger than the particle diameter to reduce compression of the particles during delivery, which can eject therapeutic agent from the particle prematurely. While compression can result in release of therapeutic agent, the metering region can retard substantial release under low compression force. In embodiments, the particles are compressed during delivery in order to use a delivery device that has a small diameter to reduce patient trauma or more accurately position the particles about a lesion. The carrier fluid in which the particles are suspended can include therapeutic agent so that upon recovery to normal diameter, the agent is drawn into the pores of the particle. For example, the particles can be delivered through a catheter having a lumen area that is smaller, e.g. 50% smaller or less, than the uncompressed cross-sectional area of the particles. The compression force is provided indirectly by increasing the pressure applied to the carrier fluid by pressing the syringe plunger. The particles are relatively easily compressed to diameters sufficient for delivery into the body. The robust, rigid surface region resists abrasion when the embolic particles contact hard surfaces such as syringe surfaces, hard plastic or metal stopcock surfaces, and the catheter lumen wall (e.g. Teflon) during delivery. Once in the body, the particles recover to original diameter for efficient transport in the carrier and body fluid stream. At the point of occlusion, the particles can again compress as they aggregate in an occlusion region. The particles form a dense occluding mass. The compression in the body is limited and the number of embolic particles needed to occlude a given diameter may be reduced. The particles can also be delivered directly into a tissue mass where reexpansion to a larger diameter firmy lodges the particle into the tissue.
In embodiments, the particles have a diameter in the range of 1 cm or less, e.g., 5 mm to 1 mm or less, e.g., about 1200 microns or less, and about 10 microns or more, e.g. about 400 microns or more and the pores are about 50 or 35 to 0.01 micron. Preferably, the particles are classified in size ranges of about 500-700 microns, about 700-900 microns, or about 900-1200 microns. The particles have a mean diameter in approximately the middle of the range and variance of about 20% or less, e.g. 15% or 10% or less.
Referring specifically to
The size of the pores in each of the regions can also be characterized by a distribution. In embodiments, the predominant pore size(s) in the center region being greater than the predominant pore size(s) in the body region and the predominant pore size(s) in the body region is greater than the predominant pore size(s) in the surface region. In embodiments, in the predominant pore size in the center region is 20 micron or more, e.g. 30 microns or more, or in the range of about 20 to 35 microns. The predominant pore size in the body region is about 18 micron or less, e.g. about 15 micron or less, or in the range of about 18 to 2 micron. The pores in the surface region are preferably predominantly less than about 1 micron, e.g. about 0.1 to 0.01 micron.
In embodiments, the predominant pore size in the body region is about 50 to 70% of the pore size in the center region and the pore size in the surface region is about 10% or less, e.g. about 2% of the pore size in the body region. The size of the pores on the outer surface of the particle is predominantly in the range of about 1 micron or less, e.g. about 0.1 or 0.01 micron. In embodiments, the surface and/or surface region is substantially free of pores having a diameter larger than about 10 micron or larger than about 1 micron. In embodiments, the predominant pore size is in the region 0.8 or 0.9 r to r is about 1 micron or less, e.g. 0.5 to 0.1 micron or less. The region from the center of the particle to 0.8 or 0.9 r has pores of about 10 micron or greater and/or has a predominant pore size of about 2 to 35 micron. In embodiments, the predominant pore size in the region 0.8 or 0.9 r to r is about 5% or less, e.g. 1% or 0.3% or less than the predominant pore size in the region from the center to 0.9 r. the largest pores in the particles can have a size in the range of 1% or 5% or 10% or more of the particle diameter.
The size of the pores can be measured by viewing a cross-section as in
The density of the particles is such that they are readily suspended in the carrier fluid such as a mixture of saline and contrast solution and remain suspended during delivery. In embodiments, the density is in about 1.1-1.4 g/cm3. For suspension in a saline-contrast solution, the density is about 1.2-1.3 g/cm3. The sphericity after compression in a catheter to about 50% or more of their cross-sectional area is about 0.90 or 0.95 or greater. In embodiments, the particles can be manually compressed, essentially flattened, while wet to less than 50% of original diameter and then, upon exposure to fluid, regain a sphericity of about 0.9 or more. The carrier fluid can be a pharmaceutically acceptable carrier such as saline or contrast agent or therapeutic agent or a combination of these carriers. The particles or composition can be sterilized.
Referring to
A base polymer and a gelling precursor are dissolved in water and mixed. The mixture is introduced to a high pressure pumping apparatus, such as a syringe pump (e.g., model PHD4400, Harvard Apparatus, Holliston, Mass.). Examples of base polymers include polyvinyl alcohol, polyacrylic acid, polymethacrylic acid, poly vinyl sulfonate, carboxymethyl cellulose, hydroxyethyl cellulose, substituted cellulose, polyacrylamide, polyethylene glycol, polyamides, polyureas, polyurethanes, polyester, polyethers, polystyrene, polysaccharide, polylactic acid, polyethylene, polymethylmethacrylate and copolymers or mixtures thereof. A preferred polymer is polyvinyl alcohol. The polyvinyl alcohol, in particular, is hydrolyzed in the range of 80 to 99%. The weight average molecular weight of the base polymer can be in the range of 9000 to 186,000, 85,000 to 146,000 or 89,000 to 98,000. Gelling precursors include, for example, alginates, alginate salts, xanthan gums, natural gum, agar, agarose, chitosan, carrageenan, fucoidan, furcellaran, laminaran, hypnea, eucheuma, gum arabic, gum ghatti, gum karaya, gum tragacanth, hyaluronic acid, locust beam gum, arabinogalactan, pectin, amylopectin, other water soluble polysaccharides and other ionically crosslinkable polymers. A particular gelling precursor is sodium alginate. A preferred sodium alginate is high guluronic acid, stem-derived alginate (e.g. about 50 or 60% or more guluronic acid with a low viscosity e.g. about 20 to 80 cps at 20� C.) which produces a high tensile, robust gel. High molecular weight PVA is dissolved in water by heating, typically above about 70� C., while alginates can be dissolved at room temperature. The PVA can be dissolved by mixing PVA and alginate together in a vessel which is heated to autoclave temperature (about 121� C.). Alternatively, the PVA can be disposed in water and heated and the alginate subsequently added at room temperature to avoid exposing the alginate to high temperature. Heat can also be applied by microwave application. For PVA/alginate, the mixture is typically about 7.5 to 8.5%, e.g. about 8% by weight PVA and about 1.5 to 2.5%, e.g. about 2%, by weight alginate.
Referring to
The drop generator 310 generates substantially spherical drops of predetermined diameter by forcing a stream of the mixture of base polymer and gelling precursor through a nozzle which is subject to a periodic disturbance to break up the jet stream into drops. The jet stream can be broken into drops by vibratory action generated for example, by an electrostatic or piezoelectric element. The drop size is controlled by controlling the flow rate, viscosity, amplitude, and frequency at which the element is driven. Lower flow rates and higher frequencies produce smaller drops. A suitable electrostatic drop generator 310 is available from NISCO Engineering, model NISCO Encapsulation unit VAR D, Zurich, Switzerland. In embodiments, the frequency is in the range of about 0.1 to 0.8 kHz. The flow rate through the droplet generator is in the range of about 1 to 12 mL per minute. The drop generator can include charging the drops after formation such that mutual repulsion between drops prevents drop aggregation as they travel from the generator to the gelling vessels. Charging may be achieved by, e.g. an electrostatic charging device such as a charged ring positioned downstream of the nozzle.
Drops of the base polymer and gelling precursor mixture are captured in the gelling vessel 320. The gelling vessel 320 contains a gelling agent which interacts with the gelling precursor to stabilize drops by forming a stable gel. Suitable gelling agents include, for example, a divalent cation such as alkali metal salt, alkaline earth metal salt or a transition metal salt that can ionically crosslink with the gelling agent. An inorganic salt, for example, a calcium, barium, zinc or magnesium salt can be used as a gelling agent. In embodiments, particularly those using an alginate gelling precursor, a suitable gelling agent is calcium chloride. The calcium cations have an affinity for carboxylic groups in the gelling precursor. The cations complex with carboxylic groups in the gelling precursor resulting in encapsulation of the base polymer in a matrix of gelling precursor.
Referring to
Following drop stabilization, the gelling solution is decanted from the solid drops and the stabilized drops are transferred to the reactor vessel 330. In the reactor vessel 330, the stabilized drops are reacted to produce precursor particles. The reactor vessel includes an agent that chemically reacts with the base polymer, e.g. to cause crosslinking between polymer chains and/or within a polymer chain. The agent diffuses into the stabilized drops from the surface of the particle in a gradient which, it is believed, provides more crosslinking near the surface of the stabilized drop compared to the body and center of the drop. Reaction is greatest at the surface of the drop, providing a stiff, abrasion resistant exterior. For polyvinyl alcohol, for example, the vessel 330 includes aldehydes, such as formaldehyde, glyoxal, benzaldehyde, aterephthalaldehyde, succinaldehyde and glutaraldehyde for the acetalization of polyvinyl alcohol. The vessel 330 also includes an acid, for example, strong acids such as sulfuric acid, hydrochloric acid, nitric acid and weak acids such as acetic acid, formic acid and phosphoric acid. In embodiments, the reaction is primarily a 1,3 acetalization:
This intra-chain acetalization reaction can be carried out with relatively low probability of inter-chain crosslinking as described in John G. Pritchard "Poly(Vinyl Alcohol) Basic Properties And Uses (Polymer Monograph, vol. 4) (see p. 93-97), Gordon and Breach, Science Publishers LTD., London, 1970, the entire contents of which is hereby incorporated by reference. Some OH groups along a polymer chain may remain unconverted since the reaction proceeds in a random fashion and there will be left over OH groups that do not react with adjacent groups.
Adjusting the amount of aldehyde and acid used, reaction time and reaction temperature can control the degree of acetalization. In embodiments, the reaction time is e.g., 5 minutes to 1 hour, 10 to 40 minutes or 20 minutes. The reaction temperature can be 25� C. to 150� C. or 75� C. to 130� C. or 65� C. The reactor vessel is placed in a water bath fitted with a orbital motion mixer. The crosslinked precursor particles are washed several times with deionized water to neutralize the particles and remove any residual acidic solution.
The precursor particles are transferred to the dissolution chamber 340 to remove the gelling precursor, e.g. by an ion exchange reaction. In embodiments, sodium alginate is removed by ion exchange with a solution of sodium hexa-metaphosphate (EM Science). The solution can include, for example, ethylenediaminetetraacetic acid (EDTA), citric acid, other acids and phosphates. The concentration of the sodium hexa-metaphosphate can be, for example, 1-20 weight %, 1-10 weight % or 5 weight % in deionized water. Residual gelling precursor, for example, sodium alginate, can be determined by an assay for detection of uronic acids in, for example, alginates containing mannuronic and guluronic acid residues. Residual alginate, for example, may be present in the range of about 20-35% by weight prior to rinsing and in the range of about 0.01-0.5% or 0.1-0.3% or 0.18% in the particles after rinsing for 30 minutes in water at about 23� C.
The particles are filtered through filter 350 to remove residual debris. Particles of 500 to 700 microns are filtered through a sieve of 710 microns and then a sieve of 300 microns. Particles of 700 to 900 microns are filtered through a sieve of 1000 microns and then a sieve of 500 microns. Particles of 900 to 1200 microns are filtered through a sieve of 1180 microns and then a sieve of 710 microns.
The filtered particles are sterilized by a low temperature technique such as e-beam irradiation, and packaged, typically about 1 to 5 ml of particles in about 5 to 10 ml saline. In embodiments, electron beam irradiation can be used to pharmaceutically sterilize the particles to reduce bioburden. In e-beam sterilization, an electron beam is accelerated using magnetic and electric fields, and focused into a beam of energy. This resultant beam can be scanned by means of an electromagnet to produce a "curtain" of accelerated electrons. The accelerated electron beam penetrates the collection of embolic particles to confer upon them electrons which destroy bacteria and mold to sterilize and reduce the bioburden in the embolic particles. Electron beam sterilization can be carried out by sterilization vendors such as Titan Scan, Lima, Ohio.
The therapeutic agent can be incorporated in the particle at various stages. As discussed above, the agent may be added to the particle after particle formation. For example, the particle can be dried and rehydrated with the therapeutic agent or a solution including the therapeutic agent. Alternatively, the therapeutic agent can be added during particle formation. For example, the agent can be mixed with PVA and alginate upstream of droplet formation or after droplet formation in the gelling vessel, reaction vessel, or dissolution chamber or in a separate step after any of these stages. The particles may also be used to deliver therapeutic agent at the stabilized drop stage without cross-linking the base polymer or at the precursor particle stage with crosslinked base polymer with or without removing the gelling precursor or gelling agent. Alternatively, the therapeutic agent can be provided only to the surface and/or metering region, e.g., by coating particle, without including substantial amounts of agent in the interior portions of the particle, e.g., the reservoir region.
The particles can be coated to include high concentration of therapeutic agent on their surface. The agent on the surface can release an initial dosage of agent while agent in the body of the particle provides a prolonged dosage over the extended period of time. The agent on the surface can be the same or different from the agent in the body of the particle. The agent on the surface can be applied by exposing the particle to a high concentration solution of the agent. The agent coated particle can include another coating over the surface the therapeutic agent, e.g., a degradable polymer which erodes when the particle is administered or meters drug out flow from the surface, e.g., by providing a porous membrane. The coating can delay an initial burst of drug release. The coating can be applied by dipping or spraying the particle. The erodable polymer could be a polysaccharide, such as an alginate. Suitable material for alginate coatings are described in Edwards-Levy Biomaterials 1999, November 20 (21) 2069-84; J. Microencapsol. 1999 May-June 16(3); 291-301; and Takka et al. J. Microencapsol. 1999 May-June 16(3), 275-90. Other erodable coatings include water soluable polymers such as polyvinyl alcohol, e.g., that has not been cross-linked. Other coatings include biodegradeable poly DL-lactide-poly ethylene glycol (PELA) discussed in Zhou et al. J. Control Release 2001 Jul. 10; 75; (1-2):27-36 or gelatin as discussed in Huang et al. Int. J. Pharm 1995 May 10 182(1):93-100. Other coatings include hydrogels such as polyacrylic acid, haluronic acid, gelatin, or carboxymethyl cellulose. Other coatings include polyethylene glycols (PEG), chitosan, polyesters such as polycaprolactones, and poly(de-lactic coglycolic acid (PLGA). Suitable coatings of these types are discussed in J. Control Release, vol. 78, 1-3, 17 Jan. 2002, pp. 15-24. The coatings can include therapeutic agent or be substantially free of therapeutic agent. The therapeutic agent in the coating can be the same or different as an agent on a surface layer of the particle and/or within the particle. A polymer coating, e.g. an erodable coating, can be applied to the particle surface in cases where a high concentration of drug has not been applied to the particle surface. The fluoroscopic visibility of the particle can be enhanced by incorporating a highly radiopaque material such as a metal, e.g. tantalum or platinum into the polymer matrix of the particle or the coating
The particles can be modified by chemical or physical modifications that affect attachment and/or release of the therapeutic agent, the visibility of the particles, or their shape. For example, the polymer of the particle can be modified by graft polymerization to, for example, provide a reactive side chain. A therapeutic agent is attached covelantly or ionically to the reactive moiety of the graft polymer. A polymer that is grafted to the particle can be further polymerized to influence polymer chain length to create a molecular level morphology or vary hydrophobicity. Suitable graft polymers include polymers with carboxylic acid, anhydride, or aceto-acetyl groups which can be grafted to, e.g. PVA side groups modified to provide acrylic acids. Graft polymerization is discussed in Biomaterials, 2002 Feb. 23 (3) 863-71 and "Polyvinyl Alcohol Developments," Ed. C. A. Finch, John Whiley, 1992 (see especially sections 6.2.3 and 7.3.1). Suitable graft polymers also include peptides that include cell binding domains. Examples are discussed in Hubbell, Biomacromolecules, 2002, vol. 3, 710-23. Species capable of cell membrane penetrations e.g. polyluecine oligomer can be attached to the particle to enhance cell attachment. Targeting ligands such as galactose can be introduced onto the surface of a particle. Galactose attachment onto polymers is discussed in Biotechnology Bioengineering, 2002 April 5 (78) 1-10. The grafted segment can be provided with reactive moieties such as amines, carboxylic acids or thiols to which therapeutic agent can be attached. The moieties can be used to modify the hydrophobic/hydrophilic and catonic/anionic nature of the particle surface. An example of a polymer that can be grafted is poly(vinyl alcohol)-graft-poly(lactic-co-glycolic acid) to produce brush-like branched polyesters for enhancing protein release, as discussed in Frauke-Pistel et al. J. Control Release 2001 May 18; 73(1):7-20. Particle charged and hydrophobicity can be modified by grafting. For example, a negatively charged hydrophilic backbone poly (2-sulfobutyl vinyl alcohol)-g-poly(lactide-co-glycolide) is described in Jung et al. J. Control Release 2000 Jul. 3; 67(2-3):157-69.
The polymer of the particle can also be modified by, e.g. block copolymerization to provide reactive moieties for graft polymerization and/or for direct therapeutic agent attachment. The polymer can also be modified to provide reactive groups at specific sites. For example, hydroxyl groups of PVA can be modified to provide more reactive sites, such as e.g. amines, carboxylic acids, or thiols.
Release kinetics can also be modified by controlling crosslinking. Techniques for crosslinking PVA and controlling release kinetics are discussed in Kim et al. Pharmaceutical Research, vol. 9, No. 1 (1992); Cosmetic and Pharm. App. For Polymers, August 1990 p. 709-14; and Polymer Mater. Sci. Eng. (1990) vol. 63, p. 64-7. Crosslinking is also described in A. R. Bachtsi and C. Kiparissides Journal of Microencapsulation, 1995, vol. 12 part 1, p. 23-35; Tobata et al. J. Control Release vol. 50, part 1-3, p. 123-133; and Orenti et al., Arch. Pharm (Weinheim) 2000 December: 333 (12), 421-4 and Sappimath et al., J. Biomat. Sci. Polym. Ed. 2000j 11(i); 27-43.
The shape of the particles can be modified by physical deformation followed by crosslinking as described in U.S. Ser. No. 10/116,330 filed Apr. 14, 2002, the entire contents of which is incorporated herein by reference. The particles can be coated on or incorporated into other medical devices, such as implantable devices including stents, embolization coils, arterial filters, artificial heart valves, catheters, and balloons such as angioplasty balloons. Other medical delivery includes wound dressings.
Therapeutic agents include materials that are biologically active to treat physiological condition. The agent can be active in release from the particle to tissue or active as it resides in the particle and is exposed to tissue or body fluid in communication with the particle.
The term "therapeutic agent" includes one or more "therapeutic agents" or "drugs". The terms "therapeutic agents" and "drugs" are used interchangeably and include pharmaceutically active compounds, nucleic acids with and without carrier vectors such as lipids, compacting agents (such as histones), virus (such as adenovirus, adeno-associated virus, retrovirus, lentivirus and a-virus), polymers, hyaluronic acid, gene therapies, proteins, cells, stem cells and the like, or combinations thereof, with or without targeting sequences.
Specific examples of therapeutic agents include, for example, pharmaceutically active compounds, proteins, cells, stem cells, oligonucleotides, ribozymes, antisense oligonucleotides, DNA compacting agents, gene/vector systems (i.e., any vehicle that allows for the uptake and expression of nucleic acids), nucleic acids (including, for example, recombinant nucleic acids; naked DNA, cDNA, RNA; genomic DNA, cDNA or RNA in a noninfectious vector or in a viral vector and which further may have attached peptide targeting sequences; antisense nucleic acid (RNA or DNA); and DNA chimeras which include gene sequences and encoding for ferry proteins such as membrane translocating sequences ("MTS") and herpes simplex virus-1 ("VP22")), and viral, liposomes and cationic and anionic polymers and neutral polymers that are selected from a number of types depending on the desired application. Non-limiting examples of virus vectors or vectors derived from viral sources include adenoviral vectors, herpes simplex vectors, papilloma vectors, adeno-associated vectors, retroviral vectors, and the like. Non-limiting examples of biologically active solutes include anti-thrombogenic agents such as heparin, heparin derivatives, urokinase, and PPACK (dextrophenylalanine proline arginine chloromethylketone); antioxidants such as probucol and retinoic acid; angiogenic and anti-angiogenic agents and factors; agents blocking smooth muscle cell proliferation such as rapamycin, angiopeptin, and monoclonal antibodies capable of blocking smooth muscle cell proliferation; anti-inflammatory agents such as dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalazine, acetyl salicylic acid, and mesalamine; calcium entry blockers such as verapamil, diltiazem and nifedipine; antineoplastic/antiproliferative/anti-mitotic agents such as paclitaxel, 5-fluorouracil, methotrexate, doxorubicin, daunorubicin, cyclosporine, cisplatin, vinblastine, vincristine, epothilones, endostatin, angiostatin and thymidine kinase inhibitors; antimicrobials such as triclosan, dephalosporins, aminoglycosides, and nitrofurantoin; anesthetic agents such as lidocaine, bupivacaine, and ropivacaine; nitrix oxide (NO) donors such as lisidomine, molsidomine, L-argine, NO-protein adducts, NO-carbohydrate adducts, polymeric or oligomeric NO adducts; anti-coagulants such as D-Phe-Pro-Arg chloromethyl ketone, an RGD peptide-containing compound, heparine, antithrombin compounds, platelet receptor antagonists, anti-thrombin antibodies, anti-platelet receptor antibodies, enoxaparin, hirudin, Warafin sodium, Dicumarol, aspirin, prostaglandin inhibitors, platelet inhibitors and tick antiplatelet factors; vascular cell growth promoters such as growth factors, growth factor receptor antagonists, transcriptional activators, and translational promoters; vascular cell growth inhibitors such as growth factor inhibitors, growth factor receptor antagonists, transcriptional repressors, translational repressors, replication inhibitors, inhibitory antibodies, antibodies directed against growth factors, bifunctional molecules consisting of a growth factor and a cytotoxin, bifunctional molecules consisting of an antibody and a cytotoxin; cholesterol-lowering agents; vasodilating agents; agents which interfere with endogenous vasoactive mechanisms; survival genes which protect against cell death, such as anti-apoptotic Bcl-2 family factors and Akt kinase; and combinations thereof. Cells can be of human origin (autologous or allogenic) or from an animal source (xenogeneic), genetically engineered if desired to deliver proteins of interest at the injection site. The delivery mediated is formulated as needed to maintain cell function and viability. Any modifications are routinely made by one skilled in the art.
Useful polynucleotide sequences include DNA or RNA sequences having a therapeutic effect after being taken up by a cell. Examples of therapeutic polynucleotides include anti-sense DNA and RNA; DNA coding for an anti-sense RNA; or DNA coding for tRNA or rRNA to replace defective or deficient endogenous molecules. The polynucleotides can also code for therapeutic proteins or polypeptides. A polypeptide is understood to be any translation product of a polynucleotide regardless of size, and whether glycosylated or not. Therapeutic proteins and polypeptides include as primary example, those proteins or polypeptides that can compensate for defective or deficient species in an animal, or those that act through toxic effects to limit or remove harmful cells from the body. In addition, the polypeptides or proteins that can be injected, or whose DNA can be incorporated, include without limitation, angiogenic factors and other molecules competent to induce angiogenesis, including acidic and basic fibroblast growth factors, vascular endothelial growth factor, hif-1, epidermal growth factor, transforming growth factor α and β, platelet-derived endothelial growth factor, platelet-derived growth factor, tumor necrosis factor α, hepatocyte growth factor and insulin like growth factor; growth factors; cell cycle inhibitors including CDK inhibitors, anti-restenosis agents, including p15, p16, p18, p19, p21, p27, p53, p57, Rb, nFkB and E2F decoys, thymidine kinase ("TK) and combinations thereof and other agents useful for interfering with cell proliferation, including agents for treating malignancies; and combinations thereof. Still other useful factors, which can be provided as polypeptides or as DNA encoding these polypeptides, include monocyte chemoattractant protein ("MCP-1"), and the family of bone morphogenic proteins ("BMP's"). The known proteins include BMP-2, BMP-3, BMP-4, BMP-5, BMP-6 (Vgr-1), BMP-7 (OP-1), BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-14, BMP-15, and BMP-16. These dimeric proteins can be provided as homodimers, heterodimers, or combinations thereof, alone or together with other molecules. Alternatively, or in addition, molecules capable of inducing an upstream or downstream effect of a BMP can be provided. Such molecules include any of the "hedgehog" proteins, or the DNA's encoding them.
Therapeutic agents include one or more of the following therapeutic agents: cells, stem cells, virus, protein, drug, enzymes, or combinations thereof.
Organs and tissues that may be treated include any mammalian tissue or organ, whether injected in vivo or ex vivo. Non-limiting examples include heart, lung, brain, liver, skeletal muscle, smooth muscle, kidney, bladder, intestines, stomach, pancreas, ovary, prostate, eye, tumors, cartilage and bone.
Other examples of therapeutic agents include the following.
Immunologic species such as antigens captured from specific cell lines (e.g. cancerous) can be absorbed/adsorbed or attached to surface of a particle, which can then be injected at the targeted cell mass, tissue or organ, e.g. a cancer site, to begin an immunologic reaction/cascade/response. Examples include HuRx, and DCVax from Northwest BioTherapeutics Inc., Bothell, Wash. An antigen or genetically engineered molecule can also be used. For example, anti-EGF receptor antibodies which help lengthen the time chemotherapy can be used as a treatment for colorectal cancer can be used. Examples include Cetuximab from ImClone Systems, New York, N.Y. Antibodies or receptors, genetically engineered or not, can also be used. Monoclonal antibodies to cells of blood vessels interact in the angiogenesis cascade, which is important for the growth of tumors can be used.
Radioactive molecules for radiopacity and/or treatment for cancer may be absorbed/adsorbed or attached to the surface of PVA particulates. Examples include radioactive materials such as iodine (131), gold or yttrium.
Proteins required for signaling pathways may be absorbed/adsorbed or attached to the surface of the particulate including antibodies, antigens, monoclonal antibodies, proteins found on cancer cells, proteins found on diseased cells in any system, proteins found on normal, nondiseased state cells in any system, or others. Signaling pathways of interest include pathways for cell regeneration, for cell death, for angiogenesis, for cell growth, for chronic heart failure, for cell differentiation or others. Suitable proteins include platelet derived growth factor BB as described in Bourke, 2002 Society for Biomaterials 28th Annual Meeting Transactions, page 144. Another particular therapeutic agent is vascular endothelial growth factor (VEGF) for enhancing endothelialization as described in J. Control Release, 2001, May 14, 14:72(1-3):101-13.
Complete whole cells, pieces of cells, genetically engineered cells or cells made of components of more than one organism may be attached to the surface of the particulate. Treatment includes diabetes or any disease caused by the cells of that organ lacking in producing a specific hormone/protein/organic molecule, cancer or Alzheimer's disease or diseases caused by the cells producing an incorrect product that is not in their function to create.
Antimicrobial coatings could coat the surface of the PVA particulate to aid in lessening infection/immunologic response to the presence of these products in the body. Coatings include the use of zinc, silver, iodine, triclosan and/or ciprofloxacin in a resin/polymer such as polyurethane.
Antigrowth drugs for cancer treatment may be absorbed/adsorbed or attached to the surface of the particle. Examples include Herceptin and Gleevec from Genetech and Novartis respectively. Small molecule chemotherapy drugs for targeted cancer treatment. Examples include, Ethiodol, Doxorubicin, Cisplatin and Mitomycin-C.
Particular therapeutic agents for treatment of liver tumors include agents used in chemoembolization, such as carboplatin, cisplatin, doxorobicin, mytomycinc and ethiodol, as discussed in Jean-Francois Geschwind, Dimitri Artemov et al., Journal of Vascular Interventional Radiology (2000) 11:1245-1255; Dheeraj Rajan, Michael Soulen et al, Journal of Vascular Interventional Radiology (2001) 12:187-193; and Leung, Goin and Sickies et al., Journal of Vascular Interventional Radiology (2001) 12:321-326. A particular tumor-toxic agent e.g. for liver treatment is paclitaxol, available from Bristol-Meyers Squib, New York, N.Y.
Particular therapeutic agents useful for treatment of uterine fibroid tumors include nonsteriodal anti-inflammatory medication, oral contraceptives, progestins, and gonadotrophin-releasing hormone agonists which may cause fibroid tumors to shrink as described in Levy et al., Journal of Women's' Imaging 2(4):168-175, 2000. Other therapeutic agents for uterine fibroid shrinkage include lupron, as discussed in Lipman, Appl. Radiol. 29(7):15-20, 2000.
Therapeutic agent may also include agents which bind to specific biological environments. The agents could, for example be placed on the exterior of the particle to make the particle targetable. The particles can be used for oral or topical administration as well as percutaneous administration. The particles can be used in chemoembolization in which drug is injected to a site and the particles are used to embolize the vasculature. The particles can include the same or a different agent or no agent. The particles can be used in combination with hydrogel based aneurysm embolization systems as described in Cruise et al., 2002, Society for Biomaterials 28th Annual Meeting Transactions, page 203. Other applications include drug delivery for treatment of anyeurums, coronary artery disease, restenosis and benign prostatic hyperplasia, e.g. in combination with medical devices such as stents.
Particles are manufactured from an aqueous solution containing 8 weight % of polyvinyl alcohol, 99+% hydrolyzed, average Mw 89,000-120,000 (ALDRICH) and 2 weight % of gelling precursor, sodium alginate, PRONOVA UPLVG, (FMC BioPolymer, Princeton, N.J.) in deionized water and the mixture is heated to about 121� C. The solution has a viscosity of about 310 centipoise at room temperature and a viscosity of about 160 cps at 65� C. Using a syringe pump (Harvard Apparatus), the mixture is fed to drop generator (Nisco Engineering). Drops are directed into a gelling vessel containing 2 weight % of calcium chloride in deionized water and stirred with a stirring bar. The calcium chloride solution is decanted within about three minutes to avoid substantial leaching of the polyvinyl alcohol from the drops into the solution. The drops are added to the reaction vessel containing a solution of 4% by weight of formaldehyde (37 wt % in methanol) and 20% by weight sulfuric acid (95-98% concentrated). The reaction solution is stirred at 65� C. for 20 minutes. Precursor particles are rinsed with deionized water (3�300 mL) to remove residual acidic solution. The sodium alginate is substantially removed by soaking the precursor particles in a solution of 5 weight % of sodium hexa-metaphosphate in deionized water for 0.5 hour. The solution is rinsed in deionized water to remove residual phosphate and alginate. The particles are filtered by sieving, as discussed above, placed in saline (USP 0.9% NaCl) and followed by irradiation sterilization.
Particles were produced at the nozzle diameters, nozzle frequencies and flow rates (amplitude about 80% of maximum) described in Table I.
Suspendability is measured at room temperature by mixing a solution of 2 ml of particles in 5 ml of saline and 5 ml of contrast solution (Omnipaque 300, Nycomed, Buckinghamshire, UK) and observing the time for about 50% of the particles to enter suspension, i.e. not sink to the bottom or float to the top of a container (about 10 ml, 25 mm dia vial). Suspendability provides a practical measure of how long the particles will remain suspended in use. (Omnipaque is an aqueous solution of Tohexol, N.N.-Bis (2,3-dihydroxypropyl)-T-[N-(2,3-dihydroxypropyl)-acetamide]-2,4,6-trilodo-isophthalamide; Omnipaque 300 contains 647 mg of iohexol equivalent to 300 mg of organic iodine per ml. The specific gravity of 1.349 of 37� C. and an absolute viscosity 11.8 cp at 20� C.) The particles remain in suspension for about 2-3 minutes.
Particle size uniformity and sphericity is measured using a Beckman Coulter RapidVUE Image Analyzer version 2.06 (Beckman Coulter, Miami, Fla.). Briefly, the RapidVUE takes an image of continuous-tone (gray-scale) form and converts it to a digital form through the process of sampling and quantization. The system software identifies and measures particles in an image in the form of a fiber, rod or sphere. Sphericity computation and other statistical definitions are in Appendix A, attached, which is a page from the RapidVUE operating manual.
Referring to
The particles can be dried by lypholization at −20 to 20� C. and a pressure of about 75 mtorr for about 30 to 70 hours. The dried particles can be rehydrated by exposure to liquid. Exposure to contrast solution indicates that rehydration achieves entry of fluid throughout the particle.
The entire contents of all publications and patent documents referenced herein is incorporated herein by reference.
Still further enhancements are in the following claims.
|U.S. Classification
|424/430, 424/422
|International Classification
|Cooperative Classification
|European Classification
|Sep 25, 2009
Owner name: SCIMED LIFE SYSTEMS, INC., MINNESOTA
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Owner name: SCIMED LIFE SYSTEMS, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LANPHERE, JANEL L.;MCKENNA, ERIN P.;NAIMARK, WENDY;AND OTHERS;SIGNING DATES FROM 20021219 TO 20030102;REEL/FRAME:023284/0188
|Oct 3, 2009
Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA
Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:023322/0849
Effective date: 20041222
|Jul 12, 2011
|Certificate of correction
|Oct 29, 2014
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Capture, Sacrifice, and Other Mediations
February 7, 2013 at 6:30pm
A lecture by Dr. Rey Chow, the Anne Firor Scott Professor of Literature at Duke University, based on Professor Chow's new book Transmedial Thinking about Capture (Amazon). Respondents will be Professors Devin Zuber (Pacific School of Religion) and Colleen Lye (UC Berkeley).
There will be a reception prior to the lecture at 7:00pm
Badè Museum, Pacific School of Religion, 1798 Scenic Avenue, Berkeley.


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When it comes to candy, "Super-Size" doesn't have to be a dirty word. It can actually be a whole lot of fun. Here are 5 super-sized treats to satisfy even the biggest sweet tooth (or impossible friend) on your holiday gift list.
The 4.5 Pound Gummi Bear
You're either going to think this bear is gross or great. For gummi bear fans, it's the ultimate chew.
Giant Tootsie Pops
I am a Tootsie Pop fan (chocolate and cherry flavors are the best!), so seeing these giant pops was like discovering great boots at DSW.
World's Largest Mint Stick
Weighing in at 2 lbs., this mint stick on steroids should last until President's Day.Over-the-Top Lollipop
The Melville Candy Company's Smile, Flower, and Peace Pops tip the scales at 2 lbs. And each one of these heavyweights rests on a 24-inch stick. Joe Melville (that's him above lifting a 2-lb. pop), his dad Gary Melville, and the rest of the crew at the Massachusetts-based Melville Candy Company, make these and a bazillion other pops by hand. Really.
Big Hunk XL
"Go big or go home" seems most fitting here. Annabelle's legendary Big Hunk chewy nougat bar comes in a king-sized version for your favorite hunk. Pop two in a stocking and you're stuffed.
(Sweet shopportunity: Use coupon code "golarge5″ at checkout and get 5% off these colossal candies and everything else on Candy.com! Offer valid through Dec. 10.)


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I've been a Frog user for years and tried to switch over from Frogs to Crank Bros pedals after trashing all my old pedals, but I just feel safer with the release on the Frogs. Looking to find a couple of pairs of used Frogs in good shape with no or minimal bearing play, preferably with cleats. I'd be willing to buy them or swap a couple of pair Eggbeater SLs and/or Candy Cs, all in good shape with cleats.
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Product Information:
Our tables are a great addition to any patio or deck as well as being attractive, comfortable and durable. This truly is maintenance-free furniture for the outdoors that is built to last a lifetime, so you can sit back, relax, and forget about it!
Product Details
Weights & Dimensions
|Table Shape: Square
|Primary Material: Metal
|Top Material: Plastic
|Folding: No
|Umbrella Hole: Yes
|Product Type: Dining table
|Style: Traditional
|Hardware Finish: Stainless steel
Frame Material: Plastic
Weather Resistant: Yes
|Fade Resistant: Yes
|Mosaic Design: No
|Lazy Susan Included: No
|Seating Capacity: 4
|Commercial Use: Yes
|Eco-Friendly: Yes
|Product Care: All-purpose cleaners or 1/3 bleach and water
|Country of Manufacture: United States
|Assembly Required: Yes
|Product Warranty: 20-year limited residential warranty; 1-year limited commercial warranty
About the ManufacturerIf you're searching for unique casual furniture that is attractive, comfortable, durable and virtually maintenance-free, POLYWOOD has the ideal furniture for your outdoor needs.
POLYWOOD manufactures casual outdoor furniture that you will be proud to own – for a lifetime.
POLYWOOD is a high performance wood lumber substitute manufactured from high density plastic. It consists of high density polyethylene resins, and select coloring and foaming agents. POLYWOOD is processed into a specification product that closely resemble painted and natural wood products that absorb no moisture, making them resistant to rotting, warping, cracking or splintering. In addition, POLYWOOD is compounded with permanent UV stabilized colors that eliminate the need for painting and staining, waterproofing, or stripping and resurfacing.
POLYWOOD products are impervious to many common corrosive substances including salt water as well as gasoline and hydrocarbon oils.
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Artist Willy Vandersteen Claus D. Scholz
Beschikbare series in de webshop categorie "Stripboeken"
Claus D. Scholz (ook bekend als Claus) in the
" Claus D. Scholz began his career as a shop-window decorator in Wolfsburg, Germany. His true passion was comics however, and Scholz headed for Antwerp, Belgium, to join the Vandersteen studios in 1972. Vandersteen was not in need of anyone, so he went to work for Frank Sels. For..." [ Lees meer ]


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As much as there are heroes in Egypt at the moment, the National Salvation Front could be (perhaps) called that. The Front includes prominent democracy advocate Nobel Peace laureate Mohamed ElBaradei, leftist Hamdeen Sabbahi and former Arab League chief Amr Moussa. And let's not forget the Coptic community. I've worked with many Egyptian Coptic folks over the years and they are certainly hardworking and proud:
Meanwhile the Muslim Brotherhood is ordering gangs to roam Cairo, raping women and beating men. Best comment at the above link: I'll bet Egypt has buyers' remorsi. I suppose I should not gloat. We just bagged a jihadi over here, named Abdullatif Aldosary.


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"Allure "created by J&D Cigar Co.
It's a captivating aroma ... Hand made in Nicaragua with Cuban seeds blended from the finest long filler Tobacco in Nicaragua , found in Estelí ,Condega & The Jalapa Valley .... Handpicked and inspected by our master grower and carefully blended to insure the full flavor of Estelí, the aroma of Condega and the sweetness of Jalapa. Bringing you a memorable smoking experience.
Allure is available in Habano and Connecticut wrapper grown in Ecuador. Visit www.jdcigars.com
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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
HEUVELTON The Heuvelton Central School Board of Education adopted a $12.5 million budget for the 2013-14 school year at Wednesdays meeting.
The budget is a $460,689 increase over last years and includes a 3.35-percent increase in the districts property tax levy, or amount to be raised by taxes.
Heuveltons tax levy in 2013-14 will be $3,055,539.
The property tax increase was a point of contention during Wednesday nights deliberations, with board member Thomas A. Nichols advocating applying more fund balance in order to hold the tax levy increase at 3 percent.
I think that we can achieve a 3 percent [tax levy increase] and make sure we provide stability for our educational future and at the same time show to the taxpayers that were trying to recognize their needs, too, Mr. Nichols said.
But board Vice President Dr. John P. Jack Zeh said raising the levy by too little could send the wrong signals to Albany.
He suggested the board adopt a 3.75-percent tax levy increase, raising $3,067,324.
Having higher taxes shows to the government that we are making more of a community effort and it will drive more state aid, Dr. Zeh said.
He also noted the tax levy can grow without necessarily affecting the tax rate because of growth within the district.
Dr. Zeh said the property tax rate in Heuvelton has essentially stayed the same for the past 10 years, hovering at about $20 per $1,000 of assessed property value.
Mr. Nichols made a motion to adopt the budget with a 3-percent tax levy increase, raising $3,045,161, but failed to garner enough support for the measure.
Board member Dennis G. Durant said, The school has built up a fiscally responsible foundation. Ive got to go with 3.75 percent.
Board member Keith Carmany agreed with Mr. Durant.
Its a looking-toward-the-future decision, he said.
But before the motion failed completely, board member Michelle McGaw proposed a compromise, asking, Cant we meet in the middle?
Mr. Nichols revised his motion to a 3.35 percent increase, with the backing of Dr. Zeh, and the motion was passed unanimously.
This budget represents the lowest tax levy increase in Heuvelton since the 2009-10 school year.
The budget also includes $973,051 from the fund balance. Superintendent Susan E. Todd said the school so far has not had to touch the $932,879 in fund balance it set aside for the 2012-13 school year and hopes to be able to carry it over to next years budget. The 2013-14 budget also assumes $7,191,067 in state aid and $231,654 in gap elimination adjustment restoration.
The final state aid package is expected to be finalized by the end of the week.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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Re: CF Amp Mods
frenchguy wrote:Ray, on a serious note, I would really like to hear your CF amp with all those upgrades, must sound pretty sweet and juicy like these nutz.!! bring it to the fest!!!
Tomorrow, I'm doing a comparison of my modded amp and the other one that's only had the power supply mods done. Stay tuned. Same Bat time, same Bat channel
I talked to my girls and we're doing the comparison on Wednesday evening. Report to follow.
Hammond tubes or stock tubes?
Its going to be used equipment when I sell it, so it may as well be used equipment when I buy it.
Tim deParavicini's E.A.R. Yoshino V20 Integrated Amplifier, Fosgate Signature Phono pre, Lucas Labs 12B4/OD3 LineStage, No. 50 and 51 Carverfest Tube amps, Hammond M3 tube amp, Ariston RD-40 Turntable w/ Linn Basik LSV tonearn, Grado Statement Master1 cartridge, Carver TX-8 & 11 tuners, Carver TD-12, Tascam CC-222mkII CD recorder, DBX-3BX & 200xg & 120x, CarverAudio ALV prototypes, Alesis Studio One loudspeakers, Energy Reference 22 Connoisseur, Cambridge Audio Model 8s, The Carver Research DarkStar Sub and Stax Earspeakers.
THIS SPACE FOR RENT...helping the blind to hear, one valve at a time


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|Sharkey Name Student-Athlete Of Week
|Written by Courtney Burchett
|Wednesday, 09 March 2011 17:18
Appalachian State University women's basketball player Kelsey Sharkey (Cincinnati, Ohio/St. Ursula) was honored for her stellar efforts over the past week at the 2011 Southern Conference Basketball Tournament, as the sophomore was named the SoCon Student-Athlete of the Week, the league office announced Wednesday.Sharkey posted three standouts performances over the past week at the conference tournament.
In Appalachian's 10-point quarterfinal victory over Davidson, the forward had a game-best eight rebounds, to go along with eight points and tied a career-high with six assists.
Her impressive outings did not end there, as she was unstoppable in ASU's 24-point rout of Elon in the tournament semifinals. In the game, Sharkey grabbed a career-high 16 rebounds, tied a career-best with 12 points and reset her career high in assists, dishing out seven.
In the championship game against Samford, Sharkey was yet again active on both the offensive and defensive fronts, as she hauled in nine rebounds, recorded 10 points and totaled two assists and two steals. For her stellar efforts, she was named first-team all-Southern Conference Tournament.
Sharkey holds a 3.68 GPA and is majoring in electronic media broadcasting and is the second women's basketball to be tabbed with the academic award, as teammate Courtney Freeman (Carlton, Ga./Madison County) picked up the award back in December.
The Mountaineers will wait to hear their postseason fate, but by winning the 2011 SoCon regular season title, the team has secured at least a spot in the 2011 Women's Basketball National Invitation Tournament. The WNIT field will be announced late Monday, March 14.
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- Northern New York Newspapers
- Watertown
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- NNY Living
- NNY Ads
The Jefferson County Agricultural and Farmland Protection Board will meet at 7:30 p.m. Monday to discuss 12 applications from property owners who want their land included in one of the countys three agricultural districts.
The 12 applications received in June represent 20 parcels. At least 51 percent of each parcel must either be actively farmed or highly suitable for agricultural purposes to be eligible for inclusion in a district.
E. Hartley Bonisteel, the Planning Department official managing the program, and Jay M. Matteson, Jefferson County agricultural coordinator, have reviewed the parcels to make sure they meet the program requirements and will present their findings at the board meeting.
This year, all applications except for one came from the northern portion of the county and were concerned with newer farms, according to Ms. Bonisteel.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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Hearty Split Pea Soup Recipe
5 35
For a different spin on traditional split pea soup, try this recipe. The flavor is peppery rather than smoky, and the corned beef is an unexpected, tasty change of pace. -Barbara Link, Alta Loma, California
- 1 package (16 ounces) dried split peas
- 8 cups water
- 2 medium potatoes, peeled and cubed
- 2 large onions, chopped
- 2 medium carrots, chopped
- 2 cups cubed cooked corned beef or ham
- 1/2 cup chopped celery
- 5 teaspoons chicken bouillon granules
- 1 teaspoon dried marjoram
- 1 teaspoon poultry seasoning
- 1 teaspoon rubbed sage
- 1/2 to 1 teaspoon pepper
- 1/2 teaspoon dried basil
- 1/2 teaspoon salt, optional
- In a Dutch oven, combine all ingredients; bring to a boil. Reduce heat; cover and simmer for 1-1/4 to 1-1/2 hours or until peas and vegetables are tender. Yield: 12 servings (3 quarts).
Originally published as Hearty Split Pea Soup in Taste of Home October/November 1996, p29
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Reviewed Jan. 13, 2015
"I made it without the potatoes tonight, and it was just as good. A wonderful dinner choice for a cold night!"
Reviewed Dec. 30, 2014
"My husband and i love this soup."
Reviewed Nov. 21, 2014 Edited Nov. 24, 2014
"This was terrible!! The peas were rock hard!! I followed the directions just as stated! I was very upset. Not only did I waste my time but I wasted my money!"
Reviewed Sep. 7, 2014
"This soup is delicious. I will make it over and over again."
Reviewed Sep. 3, 2014
"Unbelievable pea soup!!!! Best homemade ham and split pea soup I have ever made. Family loved,loved,loved it!!!!"


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Pleasured Amputee
Dog Toggle Switch
Doctor Ben Carson, Popeye's survivor, has some advice about school shootings, terrorists on airplanes, chopping malls, and more perilous scenarios.
With all these great tats, it's safe to say I'm the most unique person on earth. Which sounds great, until you realize how lonely it is.
It's not really fall until the Goons make fun of those haunted house people and the faces they make!
Welcome to Tony Ha (loading... loading...) wk's Pro (unreadable due to blurry texture)
The Goons make political Magic: The Gathering cards (with bonus jokes for people who actually play)!
The Comedy Goldmine examines the funniest and most creative threads from the Something Awful Forums. Although the Comedy Goldmine has changed authors many times over the years, its focus on the Something Awful Forums is still the same. Includes hilarious Photoshops, amusing work stories, parodies, and other types of oddball humor.
Copyright ©2015 Rich "Lowtax" Kyanka & Something Awful LLC.


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The toughest division in high school softball just got a whole lot tougher.
Yes, the heavyweights are back in Division I-North -- state finalist Mount St. Charles, Cumberland, and Lincoln -- and with each team only losing a couple of key players to graduation, they should again be forces to be reckoned with this spring.
And so should the other two teams in the division. Gone is the league's weak sister for the past two years, St. Raphael, but replacing the Saints are always-tough La Salle, which has been 45-21 over the last four years, and Smithfield, the Division II's winningest team over the past five seasons.
"It's the black and blue division," offered Cumberland coach Marty Crowley. "You take the three of us and bring La Salle and Smithfield over and you have a very, very tough division.
"You have to come to play every day and that's good in a way because you want to challenge yourself, and hopefully, that will translate into being better prepared for a postseason run."
The RIIL's realignment also placed East Providence in the Division I-Central with crosstown foe Bay View, Warwick Vets, Cranston West, and Division II power Barrington, while in the South sits two-time state champion Coventry, North Kingstown, Chariho, Toll Gate, and Westerly.
And while the RIIL separated the 15 teams into three leagues, they also made qualifying for the postseason a bit tougher for the teams in the North. The top four teams from each league will earn a spot in the playoffs, with the regular-season champion earning a first-round bye.
"Those eight games we play (in the North) are the season," MSC coach Cliff Mathews admitted. "You can go 12-6 and not get into the playoffs if you lose those six games in your division. It's frightening, especially when you look at the teams that are in our division."
"Whoever comes out of our division as the division championship, it will be well earned," added Crowley. "I think were all pretty evenly matched and we all have talent. It's going to be a great season."
The Division II circuit is also offering a new look with four leagues, two that will gain a lot of interest among Blackstone Valley softball teams.
In the East, Tolman and St. Raphael will be part of a group that also includes Classical, Mount Hope, Tiverton, and Moses Brown, and in the North resides Division III champ Woonsocket, Burrillville, North Smithfield, Ponaganset, Scituate, and North Providence.
Defending Division II champion Exeter/West Greenwich, which along with Moses Brown and Middletown, are perceived as the teams to beat, are in the Central with East Greenwich, Johnston, Pilgrim, West Warwick, and Cranston East, and the South contains South Kingstown, Narragansett, Middletown, Prout, Rogers, and Portsmouth.
With the Villa Novans in Division II, the nine-team Division III chase for the title expects to be a four-team battle between local teams Central Falls, Shea, and Davies and state finalist Central.
Bishop Keough, Mount Pleasant, Hope, the new Our Lady of Fatima/Rocky Hill co-op team, and first-year Block Island squad round out the division.
Here's a glance at the three divisions and the Blackstone Valley's teams that play in each of them.
Division I
With five All-Division selections returning to their lineup, including 2010 All-State junior shortstop Emily Hendricks and '09 All-State senior third baseman Nicole Silva, the Mounties (18-6 last year) will try to claim their third straight regular-season title.
Hendricks led the Mounties in hits (35), runs scored (22) and batting average (.430), while Silva, who inked a letter of intent to play for Division I Bucknell University of the Patriot League, missed half of last season with a shoulder injury, but still racked up 22 hits and a .478 average.
Junior ace pitcher Olivia Hendricks, who led all of Division I with 18 wins, is also back, as are senior catcher Alyssa Lanzi, senior first baseman Nicole Grinsell, junior center fielder Taylor Messier, and senior right fielder Hannah Gardella.
Junior designated hitter Aria DiMeo and senior left fielder Erin Rouleau also return, and two underclassmen to watch for are sophomore outfielder Cassie Gould and freshman infielder Briana Castro.
The Clippers, who went 15-6 last year (their best mark in nine seasons) bring back one of the state's premier players in senior Bethany Paul. On the mound, the All-Stater was 12-5 with five shutouts, a 1.41 ERA, and 146 strikeouts in 118 2/3 innings, and at the plate, Paul had a team-leading .429 average, .619 slugging percentage, and 24 runs scored.
Paul bats third in a formidable lineup that also has five other veteran seniors -- catcher and fellow tri-captain Kristen Peffer, second baseman and tri-captain Christina Speroni, shortstop Kaitlyn Pluta, first baseman Kelsey Cahill, and left fielder/No. 2 pitcher Kayleigh Martins.
Sophomore center fielder and leadoff batter Bridget Connors is another key to the Clippers' attack, and sophomore right fielder Sam Bertherman and junior third baseman Rebecca Geddes round out the starting nine.
The Lions, who were 13-6 last year, also return a talented All-State player in senior Alyssa McCoart, who led Lincoln in batting average (.417), slugging percentage (.750), and RBIs (19). McCoart, who signed a letter of intent to Division I Central Connecticut State University, also won seven games (four of them against division leaders) and had an ERA under 1.00.
McCoart split the pitching duties with sophomore shortstop and leadoff batter Lindsay Mayer, who established herself as the best underclassman in the state last season.
Also back for the Lions are senior second baseman Barbara Jackson, senior first baseman Chelsea Brennan, senior left fielder Marissa Walsh, junior center fielder Emma Hart, and junior catcher Allie Dzialo.
Surprisingly, the Townies have endured back-to-back losing seasons, going 13-21 during that stretch, but that could change this year with a talented team
whose strengths are in the junior and sophomore classes.
Seniors Courtney DeCastro (left field) and Alyssa Rizzini (designated hitter) lead the Townies, who also bring back sophomore pitcher Lauren Discuillo, junior second baseman Alyssa Dias, sophomore catcher Lindsee Allienello, and junior center fielder Amanda Horton.
Division II
One of the big stories of last season was Tolman's successful march in its first year as a Division II team. The Tigers, who were 50-3 in their previous three seasons as a Division III entry, went 13-7 in the Division II-South circuit and knocked off a few of the league's top teams along the way.
Gone from that team is Tolman's ace pitcher for the past four years, Micayla Kirylo, but sophomore Olivia Larson and junior Alex Lacoste will be looking to fill in her shoes. Lacoste was also the Tigers' shortstop and leadoff batter a season ago.
A huge returnee for the Tigers this season is senior catcher Veronica LeJeune, who led the team in nearly every offensive category last season.
Senior left fielder Jessica Treanor also returns, as does an exceptional group of sophomores, led by Jordyn Klemanchuck (third base), Ashley Clark (center field), Brittany Bilodeau (second base), and Jazmine Almeida (right field).
Woonsocket makes the move to this division after a dominant 17-1 season in Division III that saw them cruise to the championship.
Junior catcher and No. 3 batter Kelsey Boucher is the Villa Novans' marquee standout, while senior outfielders Brooke Badeau and junior infielder Caitlyn Marcoux are also excellent players.
The Novans also bring back other veterans such as senior outfielder Katelyn Kerrigan, senior second baseman Kearly Staples, junior outfielder Allyson Cartier, junior pitcher Michaela Ward, and sophomore first baseman Amanda Alexion.
Last spring was a breakthrough season for Burrillville, which reached double figures in victories (10) for the first time in more than a decade. With a strong group of players returning, including senior captain and center fielder Megan Mockler, the Broncos could be in store for bigger and better things.
Sophomore pitcher Cassidy Tedeschi is back after a solid freshman year, and classmate Ashley Spear returns at third base and the No. 3 spot in the lineup.
After winning just once over the past two seasons in Division I, St. Raphael Academy finds itself in Division II with a new head coach (Ron LaBree) and a young 14-player roster with seven sophomores and three freshmen. Senior Danielle Peloquin is the Saints' most experienced player.
North Smithfield also sports a young squad this season with eight freshmen and four sophomores among its 14 players. The Northmen, who have just 12 victories in the last four seasons, are led by senior Kasey Gesualdi and junior Sidra Ethier.
Ponaganset hopes to bounce back from a 4-16 record -- the Chieftains' worst mark in four years -- behind a talented team that's dominated by sophomores and juniors. Shortstop Leah Lemoine and catcher Kerri Nadeau are the senior co-captains.
Division III
Three of last season's four playoff teams (Central Falls, Davies, and Central) are returning and have the talent to return to the postseason, as well as Shea, which more than doubled its victories from the previous year and should also end up with double digits in the win column.
The Warriors, who finished in fourth place last year with an 11-5 record and have totaled 31 wins over the last three seasons, has one of the league's most experienced teams, guided by senior ace pitcher Solyris Vega, senior catcher Holly Webb, and senior third baseman Melanie Velez.
The Raiders, meanwhile, went 9-7 last season and came up two wins shy of qualifying for the playoffs. While some of the key contributors from that team is gone, they do boast one of the division's finest pitchers in senior fireballer Courtney Fenton and all-around shortstops in sophomore Jenna Senecal.
The Patriots have been 52-18 and a frequent Division III playoff participant in their four years as a fastpitch team, but now they will seek a fifth straight trip to the playoffs minus the services of their ace pitcher for the past four springs, Jen March.
But the cupboard isn't bare for new head coach Scott Cooper, who has senior Dy,Ann Cardona, junior Wilmarie Cruz, and sophomore Kaitlin Flynn leading his lineup and returning from last year's 12-4 team.
[1] http://www.pawtuckettimes.com/sites/default/files/061210MartyCrowley.jpg
[2] mailto:email@example.com


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Showing 1-24 of 155 items found in Events
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Taste of Chicago
Taste of Chicago is the nation's premier outdoor food festival showcasing the diversity of Chicago's dining community. The delicious array of food served at Taste of Chicago is complemented by music and exciting activities for the entire family. Every summer since 1980, Chicago's beautiful Grant Park on the city's magnificent lakefront has been home to the world's largest food festival.
Magnificent Mile Lights Festival
Kick off the holiday season and create your special memories on The Magnificent Mile in 2014! The BMO Harris Bank Magnificent Mile Lights Festival, the nation's largest evening holiday celebration, jump starts the holiday season on Saturday, November 22 with a full day of family friendly activities, concerts by top musical artists and the best holiday shopping. The day's excitement culminates with a grand evening parade down Michigan Avenue marshaled by Mickey Mouse and Minnie Mouse from Walt Disney World Resort in Florida, illuminating one million lights on 200 trees. The parade concludes with a grand finale fireworks show over the Chicago River.
Model Railroad Garden: Landmarks of America
The 7,500-square-foot "Model Railroad Garden: Landmarks of America" exhibition at the Chicago Botanic Garden features trains running on 1,600 feet of track, for train and garden enthusiasts to enjoy the delightful sights and sounds of the miniature trains traversing high and low through tunnels, across bridges and around buildings.
City of St. Charles RiverFest
Unique among Chicagoland festivals, Riverfest features the annual ancient sport of dragon boat racing, a 40-ton Fantasy Sand Sculpture, water ski shows, carnival, petting zoo, and an assortment of events and entertainment for all ages.
CITY:St. Charles
Boo! at the Zoo
Halloween fun awaits families at Brookfield Zoo's annual Boo! at the Zoo celebration. The popular daytime event, presented by Fisher-Price, features a Costume Parade, Costume Showcase, professional pumpkin-carving demonstrations, not-so-scary games and activities, special animal Zoo Chats, and haunted hayrides.
Kane County Flea Market
Monthly flea market at the Kane County Fairgrounds. "The Best in the Midwest or Anywhere." Up to 1000 dealers display and sell antiques, collectibles & Fancy Junque. Food served all day.
CITY:St. Charles
Chicago Pride Fest
Get ready for a flamboyant, fun party in Boystown! Show your pride while enjoying an eclectic lineup of crafts, food and entertainment from some of Chicago's finest LGBT performers.
Didier Farms' Pumpkinfest
Pumpkinfest September 19-October 31, 2015. Tractor drawn hayrides, corn maze, New! Buffalo Creek Mining Co, pony & camel rides, Animal Land, Pumpkin Playland, kiddie rides, Parakeet Encounter, Pig Races (Sat, Sun & Mon) Pumpkin Patch Café, homemade apple cider & pumpkin donuts made daily. Antique tractor display, fall produce, birthday parties and school groups by reservation only. Family farm since 1912.
Kane County Flea Market
"The Best in the Midwest or Anywhere" - Up to 1,000 dealers display and sell antiques, collectibles & Fancy Junque. A country breakfast is served on Sundays.
CITY:St. Charles
Warrenville Holly Days
Holly Days, sponsored by the Warrenville Park District is the City's annual holiday celebration that marks Santa's official entry into Warrenville. Guests can enjoy a warm bonfire, raffles, free horse and carriage rides, hot cider and cookies, and, of course, a visit with Santa. Local Park District and school dance troops, singers, and bands entertain attendees during the event. It is at this event that Warrenville officially turns on its holiday lights creating an array of colors for passersby along Route 56 to see. Holly Days, primarily for Warrenville residents, gives the community an opportunity to come together and kick off the holiday season.
Kane County Flea Market
Monthly flea market at the Kane County Fairgrounds. "The Best in the Midwest or Anywhere". Up to 1000 dealers display and sell antiques, collectibles & Fancy Junque. Food served all day.
CITY:St. Charles
Chicago Botanic Garden- Weekend Family Classes
Together, adults and children can explore cool things about how plants connect to science, art, history, and culture. Each program includes a variety of hands-on activities and projects, as well as opportunities to bring the Garden home. Programs run from November through April on Saturdays.
Glen Ellyn French Market
Visit downtown Glen Ellyn every Sunday through October, and find locally grown produce, organic meats, fresh flowers, baked goods, jewelry and much, much more.
CITY:Glen Ellyn
Elmhurst Farmers Market
Visit downtown Elmhurst on Wednesday mornings through October for the Elmhurst Farmers Market. You will find a variety of farmers and vendors selling fresh fruit, vegetables, bread, pastries, cheese, flowers, honey and more.
2nd Annual Outdoor Sculpture Walk
Take a self-guided tour of public art from June 2 to September 2 as part of the 2nd annual Sculpture Walk in downtown Oak Park. The walk features 12 world-class sculptures prominently placed among Oak Park's many shops and restaurants.
CITY:Oak Park
Retro Prom
Pick any decade and come ready to dance! Event fundraiser features: *King & Queen voting *Groove to the DJ mix *Raffles & Prizes *Finger foods & desserts from local restaurants *A Local Celebrity Lip Sync Battle General Ticket $75: includes open bar, appetizers & desserts and coat check.
St. Charles Fine Art Show
Located along the banks of the Fox River, this juried art show features 100 fine artists, live music, demonstrations and artists' awards.
CITY:St. Charles
Fountain Square
Now celebrating its 34th year, Fountain Square Art Festival is the largest and oldest fine arts fair on Chicago's majestic North Shore. Featuring the eclectic works of more than 225 juried artists, this sprawling art showcase epitomizes words like "cosmopolitan" and "sophistication." The festival takes place in downtown Evanston, just steps from the eponymous Fountain Square. It also features a popular children's art tent with fun activities overseen by the acclaimed Evanston Art Center, food, and a soothing jazz-centric music lineup.
Walking Tour of Historic Riverside
The Frederick Law Olmsted Society is pleased to offer great opportunities to learn about our historic landmark village. Discover the winding roads, delightful parks, beautiful landscapes, varied architecture and much more!
Kane County Flea Market / December, 2015
Monthly flea market at the Kane County Fairgrounds. "The Best in the Midwest or Anywhere". Up to 1000 dealers display and sell antiques, collectibles & Fancy Junque. Food served all day.
CITY:St. Charles
Chicagoland International Pipe and Tobacciana Show
The largest Pipe Smoking Club Show in the world with vendors from around the globe. On Sunday, they will have the UPCA United States of America National Pipe Smoking Championship, with the winner representing the UPCA in the World Smoking Championships. Adults only.
CITY:St. Charles
The Old House New House Home Show/Spring 2015 show
Update, renovate and refresh home surroundings with 300 award-winning contractors, select remodelers and creative craftsmen. See the latest in kitchens, baths, basements, additions, landscaping and improvements, Enjoy inspiring daily workshops.
CITY:St. Charles
Berwyn Cruise Nites in the Depot District
Head to the Depot District for the 9th Annual Cruise Nites presented by Berwyn Kia, Paisans Pizzeria & Bar, Mike & Sons Auto Services, Cicero Auto Parts, Deece Automotive! Cruise Nites take place on Tuesdays from 6-9pm in the Depot District at Windsor & Grove Avenues steps away from the Berwyn Metra Station. Enjoy your summe evenings while taking a stroll through a combination of car show and nightlife.
Uncorked Summer Nights
Experience the Oak Park Conservatory from a fresh perspective with Uncorked Summer Nights! Admission includes 2 drink tickets and appetizers. Also, included is showcase tours of the Fern, Tropical and Desert rooms. Enjoy music by the Grosso Family Band and art by Phil Malhiot. Appetizers provided by New Rose Catering and wine and craft beer by Marion Street Cheese Market.
CITY:Oak Park


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Neat Beauty Salon
Neat Beauty offers relaxing beauty treatments, facials and an array of pampering at their salon in South Wootton, King's Lynn.
Featured in Beauticians in Kings Lynn
Talking Heads & Body Talk
Look and feel fabulous with a visit to Kings Lynn's professional, relaxed and friendly hair, beauty and tanning salon, Talking Heads & Body Talk.
Featured in Hairdressers in Kings Lynn
13 Fitness
Transform your body shape, size and fitness levels in just a few weeks at King's Lynn's results-based gym, 13 Fitness.
Featured in Personal Trainers in Kings Lynn
Style Kitchens
Fallen out of love with your old kitchen ?...
Featured in Kitchen Design in Kings Lynn


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American Society for Deaf Children
Now What?
Your child has been identified as Deaf or as having a hearing loss. How do you make decisions that are right for your child and your family?
Early Visual Learning
A large body of research indicates clear benefits for early visual language with all children, regardless of their hearing status.
Knowledge Center
The premier source of information for people who must make decisions about deaf children: educators, legislators, and providers.
Learn what your deaf child needs to thrive and understand the possibilities for your child's future. Access visual language resources and support for your child's development.
Family Resources
Benefit from ASDC's organizational membership and comply with the IDEA mandate for schools encourage family involvement in the child's education.
Educator Resources
Latest Information
Parent Child Interaction Therapy
Gallaudet now offers Parent Child Interaction Therapy
Should All Deaf Children Learn Sign Language?
The benefits of learning sign language clearly outweigh the risks. For parents and families who are willing and able, this approach seems clearly preferable to an approach that focuses solely on oral communication.
Free First Year ASDC Membership
Membership is open to families, individuals, and organizations.
Family/individual membership includes a subscription to The Endeavor,
monthly email blasts with the latest on deaf children, and the ability to register for
annual conferences for diverse families to meet, learn, and share information.
About ASDC
ASDC is committed to empowering diverse families with deaf* children and youth by embracing full access to language-rich environments through mentoring, advocacy, resources, and collaborative networks.
Latest ASDC News
Help Arkansas School for the Deaf Athletes!Hello Deaf Community Members and Friends, My name is Casey Brown, and I am the head coach of the Arkansas School for the Deaf Special Olympics team. PLEASE forward this to everyone in your organization. I ask for your quick vote for my Deaf athletes to win $10,000 and...
Summer Youth Programs
Summer Youth Program for students who are deaf or hard of hearing.


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REVIEW SNAPSHOT®by PowerReviews Express
Best Uses
Reviewed by 3 customers
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Comments about Collapsible Water Bottle Craft Kit:
The product is great - durable, large & decent plastic BUT over priced. I was desperate, so I purchased them.
Best Uses
Comments about Collapsible Water Bottle Craft Kit:
These are great when you can get them. They are so awesome that we usually have to order them 6 months before the Summer Season or they are out of stock. SOOOOO Camp Directors order them now for next summer.
Best Uses
Comments about Collapsible Water Bottle Craft Kit:
I used this product as a craft for a kids overnighter at our church. The kids really enjoyed them and used them more than I thought. We are thinking about ordering them to take with us for our summer camp excursion in July. I had bought multiple packs so sharing markers wasn't an issue. I was surprised that the markers didn't run all over. Overall I was pleased.
Displaying reviews 1-3
Customer Service: email@example.com
Webmaster: firstname.lastname@example.com (Problems or suggestions related to the site only.)
Toll-free phone: (800) 288-9941
Monday through Friday, 8:00am to 7:00pm, EST
Representatives who speak Spanish are available
Monday to Friday 9 AM to 6 PM EST
Representantes que hablan Español están disponibles
Lunes a Viernes 9 AM to 6 PM EST
24-Hour toll-free fax: (800) 566-6678
S&S® Worldwide
PO Box 513
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Joel Sherman in the Post had it first, but I can confirm that Dickie Scott will be the Mets new Minor League Field Coordinator. The Mets hope to make an official announcement Tuesday. Terry Collins, who was recently named the Mets' manager, held the Field Coordinator job in 2010.
Scott was the Blue Jays Director of Player Development under J.P. Ricciardi from 2001 through 2009, but was let go when Alex Anthopoulos took over. Scott worked for the Houston Astros in 2010. Before joining the Jays, Scott was the Special Assistant to the General Manager/Advance Scout for the Oakland A's.
Here's an excerpt from a six-year old interview Scott did in 2004 for an old site called the Batters Box. Note that he's talking about on-base percentage.
BB: What's the biggest jump in the minor leagues?
DS: The biggest jump in the minor leagues in when you go from High A to Double-A — that weeds out a lot of the suspects. Guys who had good numbers at A go to Double-A, and it starts to be the real deal, because a lot of guys go from Double-A to the big leagues.
But still, the biggest jump of all is going from the minor leagues to the big leagues. At Double-A, you have your prospects, mainly your own organization guys. At Triple-A, you have a lot of six-year minor-league free agents and guys who have played in the major leagues, so there's more finesse there.
BB: Are there specific criteria for player promotion?
DS: For pitchers, they have to throw strikes. At the lower levels, through the Florida State League, guys have good numbers, but they don't command their fastball. If you can't throw your fastball for a strike, you won't pitch in the big leagues. At the lower levels, guys swing at pitches out of the zone, so the numbers are inflated. At Double-A and Triple-A, guys won't swing at those pitches, so instead of it being 1-and-2, it's 2-and-1.
For hitters we want guys who can control the strike zone and have good on-base percentage. There are a few exceptions like Nomar Garciaparra or Alfonso Soriano, but there aren't many of them.


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28 U.S. Code § 3001 - Applicability of chapter
prev | next
(a) In General.— Except as provided in subsection (b), the [1] chapter provides the exclusive civil procedures for the United States—
(b) Limitation.— To the extent that another Federal law specifies procedures for recovering on a claim or a judgment for a debt arising under such law, those procedures shall apply to such claim or judgment to the extent those procedures are inconsistent with this chapter.
(c) Amounts Owing Other Than Debts.— This chapter shall not apply with respect to an amount owing that is not a debt or to a claim for an amount owing that is not a debt.
[1] So in original. Probably should be "this".
Source(Added Pub. L. 101–647, title XXXVI, § 3611,Nov. 29, 1990, 104 Stat. 4933.)
Effective Date
Section 3631 of title XXXVI of Pub. L. 101–647provided that:
"(a) Except as provided in subsection (b), this Act [probably should be "title", meaning title XXXVI of Pub. L. 101–647, which enacted this chapter and section 2044 of this title, amended sections 550, 1962, 1963, and 2410 of this title, section 523 of Title 11, Bankruptcy, and sections 3142 and 3552 of Title 18, Crimes and Criminal Procedure, and enacted provisions set out as a note under section 1 of this title] and the amendments made by this Act [title] shall take effect 180 days after the date of the enactment of this Act [Nov. 29, 1990].
"(b)(1) The amendments made by title I of this Act [probably should be "subtitle A of this title", meaning subtitle A (§§ 3611, 3302 [3612]) of title XXXVI of Pub. L. 101–647, which enacted this chapter] shall apply with respect to actions pending on the effective date of this Act [probably should be title XXXVI of Pub. L. 101–647] in any court on—
"(A) a claim for a debt; or
"(B) a judgment for a debt.
"(2) All notices, writs, orders, and judgments in effect in such actions shall continue in effect until superseded or modified in an action under chapter 176 of title 28 of the United States Code, as added by title I of this Act [subtitle A of this title].
"(3) For purposes of this subsection—
"(A) the term 'court' means a Federal, State, or local court, and
"(B) the term 'debt' has the meaning given such term in section and [sic] 3002(3) of such chapter."
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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If you are a current member, log in using the form below.
Not a member? We invite you to view the subscriber benefits at Membership Benefits
Design & Thrive offers the tools and resources you need to market, design, promote and manage your design career.
Start today on your step-by-step journey to graphic design success by signing up via our secure online order form.


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Public Register of Environmental Information: Genetically Modified Organisms
Register of applications to release or market genetically modified organisms (GMOs)
The register contains summaries of applications for consent to release or market GMOs, including the applicants risk assessment, the advice of the Advisory Committee on Releases to the Environment (ACRE - the independent statutory committee which advises the Government) and the Secretary of State's letter giving consent to an application.
To arrange inspection of the register or for more information contact the Environment Agency
Register of Notifications
The Health and Safety Executive (HSE) holds a register of notifications seeking HSE consent from firms intending to use genetically modified organisms which could be hazardous to people and/or the environment. You will find a summary of information in individual notifications where HSE consent is required to work with genetically modified organisms in containment (e.g. laboratories). In some cases the HSE may agree to withhold certain details from the register to protect commercial confidentiality or intellectual property.
For more information including access to the register contact http://www.hse.gov.uk/


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After constant pressure she finally gave in
I Fucked My Sisters Tiny Friend In The Ass, She was So Tight She Almost Ripped My Cock Off
This is easily the best ass I have fucked yet.. I hope she wants it again
They fucked all night and now they've started again
Nephew was playing outside with friends and come to see if aunt prepares something to eat. Although milf's pussy is not a meal, it was much more than yummy and delicious.
Teen daughter didnt expect her mommy to get back from work so early today ...
Teen girl brutally fucked at isolated village house by awful alcoholic man.
Violated groped and brutally gangbanged, thats what awaits this mommy today.
Smell of her wet pussy was simply impossible to ignore.
Cruel attackers violates them both. Horrible.
Maybe MILF didn't provoke young guy down there at basement, but how could he understand this any other way?
However, that was not all what amazed boy experience that day. Husband went to work and boy left alone with his slutty wife.
Im more than sure that this one will give maximum after busty mature MILF boss leave office.
MILF teacher starts to feel strange at the middle of the class, like someone started to touch her pussy, but she couldnt see anyone near her ...
Parents were away, mature maid wave little bit too much with her butt while cleaning house, boy could's stand that anymore...
He better take cab in the future.
This video with housewife left alone with young handyman will explain you why.
Bus maniac abuse MILF in pink pantyhose at crowded bus.
... and he empty his balls deep inside wasted woman.
Wife interrupts them couple of times, but guy successfully empty his balls at the end.
Her scream didn't help at all, it only made guys enjoy much more ...
British citizens were passing by amazed with view that they had, shameless teenagers fuck infront of everybody.
Old busty british barmaid is struggling to keep her job and this is only way to keep her boss pleased about her.
Concerned aunt notice that boy is so sad lately, so she come to his room to talk with young husband's nephew about what bothers him. Porn magazine that mommy found on boy's desk answer all her questions. She decide to help...
Fortunately, aunt will have understanding for immodest husband's young cousin.
This is so wrong, but mommy could's help her self to not watch boy wanking on her panties.
Two young guys couldn't resist view that their aunt offer them.
Aunt didn't wanna fuck husband's nephew, but didn't wanna spoil his fun also.
Daughter in law was too afraid to tell old man to stop, her husband could hear that something wrong happens inside, so she decide to keep her mouth shut.
She just loves open air pleasures
this cute brunette babe slips her jeans down to her feet to expose her amazing bubble butt and then pulls her top down over her natural boobs allowing her hard nipples to be seen while she sucks a cock
Omg, whata embarrassing situation.
Too drunk to runaway and too drunk to make them stop resulted with this.
Mature real african black woman nailed by road worker while his mate was taping everything.
He thought..What an ASS, he never had that view before
Unfortunatelly, boy was simply hypnotized with smell of his MILF aunt's pussy.
She is back from the grocery store and now she confronts her drunken husband
Husband's young nephew attacked mature uncle's wife in kitchen while she was washing dishes.
Big dick big tits big ass ebony shemale mama fuck poor skinny black neighbor gay boy.
Dunno if those three are witches, but punishment is pretty bad.
In the other hand, not for all.
Looks like teenagers didn't expect their friends to appear with camera.