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SAN LUIS OBISPO, Calif. (MarketWatch) — Critical warning No. 17? Lost count? Here's the latest: "The stock market is about to have a devastating decline; we will see Dow 5,000 before we see Dow 20,000."
That's Terry Burnham, former Goldman Sachs trader, biotech entrepreneur, money manager, author of "Mean Markets and Lizard Brains: How to Profit from the New Science of Irrationality," on PBS. A former Harvard professor of behavioral economics, a guy on par with Nobel economist Daniel Kahneman; "Black Swan's" Nassim Nicholas Taleb; and Dan Ariely, author of "Predictably Irrational: The Hidden Forces That Shape Our Decisions."
Dow 5,000? Yes, investors, the big one's coming, and it's dead ahead. We've been reporting these warnings, maybe 20 this year alone. But, unfortunately, thanks to what Burnham calls the investor's "lizard brain," you can't — you won't — hear the crash coming. Till it's too late.
'Gloomiest of all gloomsters': We're repeating 1928 sucker's rally
As if to punctuate his new warning, Burnham's PBS editor added this postscript: "Over the weekend at ZeroHedge.com, the gloomiest of all gloomsters, Tyler Durden," compared the current stock market to the sucker's rally of 1928 that set up and led the lambs to the 1929 slaughter. So, history buffs, be warned that Fed Chairman Ben Bernanke's risky cheap-money bubble-blowing "depression-fighting remedies" are repeating the 1928 bull-market sucker's rally, and the "side effects could include ... another depression."
Our lizard brains lead us to buy stocks after they have gone up and blind us to the obvious realities.
Warning bells are everywhere: Dow 5,000 ... another depression ... massive denial on Wall Street and Main Street ... a new meltdown bigger than the 2000 dot-com crash ... longer than the 30-month recession of 2000-03 where Wall Street lost $8 trillion of America's retirement money ... worse than the fact that Wall Street narrowly breaks even on an inflation-adjusted basis ... and bigger than the 2008 bank-credit meltdown with the de facto bankruptcy of all Wall Street's banks ... with trillions in new debt dumped on taxpayers by the U.S. Treasury ... and Bernanke's wanton "grand experiment" showering endless cheap money into speculation ... and blowing the biggest bubble in history.
• America's $60 trillion deadliest enemy
• Doomsday poll: 98% risk of 2014 stock crash
• 'Zombie capitalism' heralds 'World War Z'
• Old guys rule? Bill Clinton says women do
Denial? Yes, massive denial. Why? Lizard brains, 95 million Main Street investors. And Wall Street crawling with a million lizard brains. That's the primitive, survival-first, irrational part of our old brain that began developing a few hundred million years ago.
You have one of these bio-algorithm drones wired in your brain. It takes over, reacts on autopilot to old fears trapped in outdated behavioral patterns that override your rational brain.
Wall Street's in denial, and so is Main Street
Here's how Burnham put it: "The signs of collapse are right in front of us. We cannot see the signs now, however, because our brains aren't built to see them ... we are more often than not at the mercy of 'lizard brains,' which evolved in lizards to drive them to eat, survive and reproduce."
Today our lizard brains "lead us to buy stocks after they have gone up and blind us to the obvious realities."
Not only are the vast majority of America's 95 million investors trapped in this bubble of denial chasing stocks, but Burnham warns that his prediction is "the opposite of the conventional wisdom" pushed by gurus like "Jeremy Siegel, author of 'Stocks for the Long Run,' who is predicting new all-time highs for stocks, while Warren Buffett, the best investor of the previous century, is 100% behind stocks."
And yet, in spite of all this happy talk from Siegel, Buffett and all Wall Street gurus and pundits, Burnham asks rhetorically: "Am I taking a risk in making such a dire forecast? Yes. I could be stuck with the label 'Mr. Dow 5,000.' "
Actually, though, he's loving it. Burnham wears his prediction as a badge of honor: "I embrace the title Mr. Dow 5,000." That's how confident he is the markets will come crashing down like in 2008, like in 2000, like in 1929.


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I lived in Europe for eleven years and the thing I miss the most, gastronomically, is a dessert called Spaghetti Eis. It is not spaghetti-flavored ice cream but rather ice cream that looks like spaghetti.
They put good vanilla gelato through a spaetzle press or potato ricer to make the noodles. On top goes either strawberry or raspberry sauce and they usually garnish with chipped coconut to resemble parmesan cheese.
It is incredible. Photo can be seen here:

subset: commoncrawl


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$1.8 million gift supports Exelon's charitable giving commitment in Maryland
BALTIMORE – Exelon and Constellation today announced a combined $1.8 million donation to the Maryland Science Center for the creation of a new, state-of-the-art exhibit that will educate visitors about how energy is produced and consumed.
"Exelon and Constellation are making a significant commitment to the Science Center, one of the jewels of our city, to create this exciting new energy exhibit," said Baltimore Mayor Stephanie Rawlings-Blake. "Public-private partnerships like this exhibit, which will draw hundreds of thousands of children from across Maryland, promise to help improve educational opportunities for students of the Baltimore City Schools."
Expected to open in late 2013, the exhibit will educate visitors about the full scope and complexity of how humans generate and use energy, from the power plants that produce electricity to the power lines that deliver it to customers' homes. In addition, the exhibit is expected to show visitors how they can use energy more efficiently to reduce their utility bills and how cleaner, alternative sources of energy can help reduce our impact on the environment.
"Exelon and Constellation believe deeply in the importance of science and math education to prepare young people to be the scientists and engineers of tomorrow," said Calvin G. Butler, Jr., senior vice president of corporate affairs at Exelon. "This new energy exhibit will help inspire Maryland schoolchildren to become the builders and operators of the nation's 21st century energy infrastructure. The Maryland Science Center is a world-class museum and the perfect home for the exhibit."
As part of its merger with Constellation in March 2012, Exelon committed to maintain charitable giving of at least $7 million each year in Maryland and Baltimore combined for the next 10 years. Exelon's gift to the Maryland Science Center fulfills part of this commitment.
In keeping with the museum's hands-on approach to learning, the new exhibit will feature interactive, multimedia displays, and the Science Center's own energy consumption and building – including its solar arrays and green roof – will be included in the exhibit.
"We commend Exelon and Constellation for their generous support in developing this innovative new energy exhibit," said Van R. Reiner, president and CEO of the Maryland Science Center. "With their partnership, the Science Center will be able to give our visitors an engaging and educational experience that will shed light on where the energy they use comes from and how they can do their parts to help conserve energy."
Exelon Corporation (NYSE:EXC) is the nation's leading competitive energy provider, with approximately $33 billion in annual revenues. Headquartered in Chicago, Exelon has operations and business activities in 47 states, the District of Columbia and Canada. Exelon is the largest competitive U.S. power generator, with approximately 35,000 megawatts of owned capacity comprising one of the nation's cleanest and lowest-cost power generation fleets. The company's Constellation business unit provides energy products and services to approximately 100,000 business and public sector customers and approximately 1 million residential customers. Exelon's utilities deliver electricity and natural gas to more than 6.6 million customers in central Maryland (BGE), northern Illinois (ComEd) and southeastern Pennsylvania (PECO).


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12 U.S. Code § 4517 - Examinations
(a) Annual examination
The Director shall annually conduct an on-site examination under this section of each regulated entity to determine the condition of the regulated entity for the purpose of ensuring its financial safety and soundness.
(b) Other examinations
In addition to annual examinations under subsection (a) of this section, the Director may conduct an examination under this section of a regulated entity whenever the Director determines that an examination is necessary or appropriate.
(c) Examiners
The Director shall appoint examiners to conduct examinations under this section. The Director may contract with the Comptroller of the Currency, the Board of Governors of the Federal Reserve System, or the Federal Deposit Insurance Corporation for the services of examiners to conduct examinations under this section. The Director shall reimburse such agencies for any costs of providing examiners from amounts available in the Federal Housing Enterprises Oversight Fund.
(d) Inspector General
There shall be within the Agency an Inspector General, who shall be appointed in accordance with section 3(a) of the Inspector General Act of 1978.
(e) Law applicable to examiners
The Director and each examiner shall have the same authority and each examiner shall be subject to the same disclosures, prohibitions, obligations, and penalties as are applicable to examiners employed by the Federal Reserve banks.
(f) Technical experts
The Director may obtain the services of any technical experts the Director considers appropriate to provide temporary technical assistance relating to examinations to the Director, officers, and employees of the Office. The Director shall describe, in the record of each examination, the nature and extent of any such temporary technical assistance.
(g) Oaths, evidence, and subpoena powers
In connection with examinations under this section, the Director shall have the authority provided under section 4641 of this title.
(h) Appointment of accountants, economists, and examiners
(1) Applicability
This section shall apply with respect to any position of examiner, accountant, economist, and specialist in financial markets and in technology at the Agency, with respect to supervision and regulation of the regulated entities, that is in the competitive service.
(2) Appointment authority
The Director may appoint candidates to any position described in paragraph (1)—
(A) in accordance with the statutes, rules, and regulations governing appointments in the excepted service; and
(i) Ombudsman
The Director shall establish, by regulation, an Office of the Ombudsman within the Agency, which shall be responsible for considering complaints and appeals, from any regulated entity and any person that has a business relationship with a regulated entity, regarding any matter relating to the regulation and supervision of such regulated entity by the Agency. The regulation issued by the Director under this subsection shall specify the authority and duties of the Office of the Ombudsman.
Source(Pub. L. 102–550, title XIII, § 1317,Oct. 28, 1992, 106 Stat. 3949; Pub. L. 110–289, div. A, title I, §§ 1105(a), (b), (e), 1153(b)(1)(A),July 30, 2008, 122 Stat. 2667, 2668, 2774; Pub. L. 111–203, title III, § 365(2),July 21, 2010, 124 Stat. 1555.)
References in Text
Section 3(a) of the Inspector General Act of 1978, referred to in subsec. (d), is section 3(a) ofPub. L. 95–452, which is set out in the Appendix to Title 5, Government Organization and Employees.
2010—Subsec. (c). Pub. L. 111–203substituted "or the Federal Deposit Insurance Corporation" for "the Federal Deposit Insurance Corporation, or the Director of the Office of Thrift Supervision".
2008—Subsec. (a). Pub. L. 110–289, § 1105(a)(1), substituted "regulated entity" for "enterprise" in two places.
Subsec. (b). Pub. L. 110–289, § 1105(a)(2), inserted "of a regulated entity" after "under this section" and substituted "or appropriate" for "to determine the condition of an enterprise for the purpose of ensuring its financial safety and soundness".
Subsec. (c). Pub. L. 110–289, § 1105(a)(3), inserted "to conduct examinations under this section" after "services of examiners".
Subsecs. (d) to (f). Pub. L. 110–289, § 1105(a)(4), (5), added subsec. (d) and redesignated former subsecs. (d) and (e) as (e) and (f), respectively. Former subsec. (f) redesignated (g).
Subsec. (g). Pub. L. 110–289, § 1153(b)(1)(A), which directed technical amendment in subsec. (f) to reference in original act which appears in text as reference to section 4641 of this title, was executed by making the amendment in subsec. (g), to reflect the probable intent of Congress and the redesignation of subsec. (f) as (g) by Pub. L. 110–289, § 1105(a)(4). See below.
Pub. L. 110–289, § 1105(a)(4), redesignatedsubsec. (f) as (g).
Subsec. (h). Pub. L. 110–289, § 1105(b), added subsec. (h).
Subsec. (i). Pub. L. 110–289, § 1105(e), added subsec. (i).
Effective Date of 2010 Amendment
Amendment by Pub. L. 111–203effective on the transfer date, see section 351 ofPub. L. 111–203, set out as a note under section 906 of Title 2, The Congress.
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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Tony Sweet Loves His Kiboko/
Professional nature photographer & workshop leader Tony Sweet recently travelled to Iceland and brought his trusty Kiboko with him. With all this Iceland love recently, I think Gura Gear will need to make a company trip there soon! He was kind enough to share a few photos with us that his friendDon Rosenberger took. He also posted a bit about Kiboko on his Facebook page.
After struggling with flight weights, I decided to get the Andy Biggs camera bag, which came in 4 lbs less than the other backpacks that I had, allowing me to bring essential camera gear that put me over the limit in the other bags. I was immediately impressed with the weight, smart design, and durability. The two front panels open up to get access to the bag, which means that you never have to lay the open front on wet sand, mud, or any other messy environment. There is an included rain cover, which can also be used to place under the bag to keep it dry in "hostile" environments.
The Kiboko is the best photo backpack out there, and is my new bag of choice.
Highly recommended!
Make sure to check out Tony's work here. Thanks Tony!


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Video: Press Conf: Buffalo Sabres Name Rolston as Head Coach
BUFFALO, NY- He served as interim head coach of the Buffalo Sabres since February, and this morning, the team made it official. Sabres General Manager Darcy Regier named Rolston as head coach of the team.
Regier and Rolston sat down and spoke to media Tuesday morning about the team moving forward.
Regier says Rolston's contract was extended for multi-years, but would not give a specific number of years. Regier said the initial plan in February was to interview other coaching candidates, but was impressed with Rolston's coaching.
Rolston says it is exciting and humbling to be named the head coach of the Sabres. He plans to make decisions soon on his coaching staff. As for player personnel, he would like to see Miller and Vanek in the line-up to start the season.
Rolston led the Sabres to a 15-11-5 record in the 31 games he served as interim head coach during the 2012-13 season. He took over the team after Lindy Ruff was fired. Rolston now becomes the 16th head coach in franchise history.
Before coming to Buffalo, Rolston was the head coach of the Rochester Americans. In his two seasons (2011-12, 2012-13), as coach of the Americans, Rolston compiled a 63-44-17 regular-season record.


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Rate Dr. Rebecca Yee
Dr. Rebecca Yee's Ratings
What an amazing doctor! You feel so welcome and well taken care of in her office. Plus she is so down-to-earth and it is easy to communicate with her. Each baby she delivers must feel well taken care of, since she does such a great job taking care of the moms.
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Very helpful, kind and considerate staff. Dr. Yee is very down to earth, patient, and never makes you feel rushed.
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the BEST experience i've ever had with a doctor...EVER. Rebecca Yee is so cool. She's not one of those old stodgy doctors. She's young, modern, and thoughtful, not to mention she knows her stuff. Awesome bedside manner, always on time, she even remembers my husbands name! She delivered my baby via an emergency c-section and did an amazing job. Can't say enough good stuff about Rebecca Yee. She is just so cool.
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I know what you mean. I moved from Puerto Rico about a year and a half ago, and it seems weird to rarely to hear anyone speak spanish. (Of course, there are many latin people in Florida, but I am not acquainted with any)natural languages that is...
I think I'm going insane and the fact that I've been away from my home (Quebec) is driving me nuts. Everywhere I hear French when people are speaking English...sort of like the Charlie Brown effect with the adults.
...plus I'm losing my French and sometimes I think I've acquired an accent, but swearing in French will always remain
I know I won't develop an accent, at least not an english one. My spanish accent is really thick in english.
Swearing is good. It is nice to be among a lot of people who don't know spanish and being able to swear without them knowing what you mean, so you don't care getting in trouble for that at work.


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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
Plans for a 364-unit apartment complex in West Carthage were scrapped in January because a market study commissioned by COR Development Co. created serious concerns for financiers, according to COR General Manager Steven F. Aiello.
We would have been pleased to have done the project there, but the market study didnt support it. There were financial challenges getting the project built there, Mr. Aiello said. We have an obligation to the state to make sure the project had the best opportunity to be successful.
In December, the project was awarded a $2 million grant through the states Regional Economic Development Council awards as part of a $90.2 million initiative to stimulate the economy and create jobs in the north country.
COR had been under contract to develop the site with Carthage-based Lunco Corp., owned by Michael E. Lundy, beginning last July 20, according to Joseph B. Gerardi, legal counsel for COR.
COR would have built the housing portion at the back of the Johnson property southwest of North Broad and Franklin streets. Lunco Corp. was to develop the 16-acre retail portion at the front of the site.
That contract was an agreement based on several contingencies, including the suitability of the site as determined by independent due diligence.
Upon completion of the proprietary market study commissioned by COR, Mr. Aiello sent a letter to Mr. Lundy stating, in part, we have determined that the Contingencies in our Purchase Agreement cannot be satisfied and the agreement is therefore terminated as of this date.
The letter is dated Jan. 3.
Last week, COR announced that it would be demolishing the former Mercy Hospital in Watertown to redevelop the site into a mixed-use complex combining residential, retail and business development.
The change in plans had nothing to do with somebody luring us away, Mr. Aiello said Tuesday.
Mr. Aiello said the urban revitalization and mixed-use opportunities presented by the Mercy site were a better fit for the criteria set forth in the market study and had a higher likelihood of success.
Our lenders are very encouraged by the site and are prepared to move forward once we get the approvals in place, Mr. Aiello said.
The $2 million grant likely will follow the project.
While the move to the Mercy site has been characterized as a victory by city and county representatives, it came as a disappointment for West Carthage officials.
We knew when COR moved on Mercy their interest was out of West Carthage, said West Carthage Mayor Scott M. Burto.
Although Mr. Lundy could not be reached for comment, Mr. Burto said he believes Mr. Lundy is still pursuing additional investors, although the scope of the project may change.
It was great news for the city of Watertown and a good reuse of Mercy, Mr. Burto said. Unfortunately for us, our Planning Board and the village spent a lot of time in filing plans to move the (Broad Street) project forward.
Village Planning Board Chairman Ronald J. Blinebry had no comment about COR pulling out except to say, Thats what a planning board does, review the plans brought to us. It doesnt matter if a plan doesnt go through.
Johnson Newspapers writer Elaine M. Avallone contributed to this report.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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Pilot Test of a Community-based Buprenorphine Treatment Intervention
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The main goal of this study is to pilot test the community-based buprenorphine treatment (CBBT) intervention, examining buprenorphine treatment initiation, opioid use, and HIV risk behaviors. Two groups of participants will be followed for 60 days, with 3 research visits. One group will be enrolled prior to the CBBT intervention (pre-intervention), and one group after the CBBT intervention (post-intervention). Data sources will include questionnaires, urine toxicology tests, and medical record data. We hypothesize that compared to the participants in the pre-intervention group, participants in the post-intervention group will be more likely to initiate buprenorphine treatment, reduce opioid use, and reduce high-risk HIV risk behaviors.
Opioid Dependence
Injection Drug Use
Behavioral: Community-based buprenorphine treatment (CBBT) intervention
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Development of a Community-based Buprenorphine Treatment Intervention
- initiation of buprenorphine treatment [ Time Frame: 60 days ] [ Designated as safety issue: No ]Medical record information will be extracted to determine initiation of buprenorphine treatment, which will be defined as a visit with a medical provider in which buprenorphine is prescribed.
- opioid use [ Time Frame: 60 days ] [ Designated as safety issue: No ]Opioid use will be determined via self-report using the Addiction Severity Index and via urine specimens (e.g., urine toxicology testing).
- HIV risk behaviors [ Time Frame: 60 days ] [ Designated as safety issue: No ]Drug- and sex-related HIV risk behaviors will be assessed using a standardized risk assessment tool used in NIDA's Clinical Trials Network.
|Study Start Date:
|December 2012
|Study Completion Date:
|February 2014
|Primary Completion Date:
|February 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
No Intervention: Pre-intervention
Participants will be enrolled prior to the implementation of the community-based buprenorphine treatment (CBBT) intervention.
Experimental: Post-intervention
Participants will be enrolled after implementing the community-based buprenorphine treatment (CBBT) intervention
Behavioral: Community-based buprenorphine treatment (CBBT) intervention
Community-based buprenorphine treatment (CBBT) intervention consists of three components which are delivered to staff of syringe exchange programs, including: 1) providing buprenorphine education, 2) facilitating access to buprenorphine treatment, and 3) providing support to individuals who initiate buprenorphine treatment.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- at least 18 years old
- English or Spanish fluency
- ever injected drugs
- not receiving buprenorphine treatment (no prescribed buprenorphine in the previous 6 months)
- clients of our collaborating community-based organization
- interested in buprenorphine treatment
Exclusion Criteria:
- pregnant
- taking more than 60mg of methadone daily in the previous 30 days
Please refer to this study by its ClinicalTrials.gov identifier: NCT01761110
|United States, New York
|Washington Heights Corner Project
|New York, New York, United States, 10033
|Principal Investigator:
|Chinazo Cunningham, MD, MS
|Albert Einstein College of Medicine of Yeshiva University
No publications provided
|Responsible Party:
|Albert Einstein College of Medicine of Yeshiva University
|ClinicalTrials.gov Identifier:
|NCT01761110 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 2, 2013
|Last Updated:
|June 24, 2015
|Health Authority:
|United States: Institutional Review Board
Keywords provided by Albert Einstein College of Medicine of Yeshiva University:
Opioid dependence
Injection drug use
Opioid agonist treatment
Access to care
HIV risk behaviors
Additional relevant MeSH terms:
Opioid-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Substance-Related Disorders
Analgesics, Opioid
Central Nervous System Agents
Central Nervous System Depressants
Narcotic Antagonists
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sensory System Agents
Therapeutic Uses
ClinicalTrials.gov processed this record on October 09, 2015


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Well, if you want a prism like that, send me another 3d file. To everyone else, fair warning, no matter how fast (and if) people give permissions and such, I'm going away soon until late June, and they won't be available for sale regardless till then. If you send me a 3d file, though, I'll probably get it handled quickly (before I leave) and you'll at least get your copies of it.
Don't know how many models I would be able to handle, the response has been pretty slow as of yet.
If you really do want them to be available quickly, if you send me a file, let me know (publicly is great, but I need an e-mail too) that I can do what I want with it in support of the CotFSM. I will only sell these in whatever way Bobby and I work out that he deems is acceptable support of the CotFSM. I can't pay money, but I'm happy to send a set your way as a big thank you.


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Call us toll-free
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From: $2.72 | Min Qty: 25 | Production Time: 8 Days
|Images are not necessarily shown in proportion to other products.
|Images are not necessarily shown in proportion to other products.


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The Army is looking for the blackest of black. A color so dark it is nearly reflective. Try this:
No need to thank me. Wired magazine gives you the details here:
Another curious thing is that the program is being run out of the Army's Program Executive Office Ammunition at the Picatinny Arsenal, a main center for the Pentagon's experiments in all sorts of weapons: from rifles and tank cannons to directed-energy weapons. But the purpose of the solicitation isn't much more specific than described. "Simply put, it's too early yet to speculate on where the technology(s) will go," Frank Misurelli, an Army spokesman at Picatinny said in a statement provided to Danger Room. "Possibly in a few months, after an contract has been awarded, more information may become available. . ."
The Army could go another route. A second option uncovered by Britain's National Physical Laboratory involves immersing an object in a solution of nickel and sodium for several hours, which blackens the color, and then taking it out and dunking it in nitric acid for a few seconds. According to New Scientist, this creates an alloy pock-marked with tiny microscopic craters that prevent light from bouncing away.
Do I see a song for this?


text:
Meditation, Karma, and Nonviolence Teachings and Practices From The Buddhist and Jain Cultures : Religion And Spirituality » Read
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The Local restaurant, opened April 29, 2013, in Bed Bath & Beyond Plaza with a farm- and sea-to-table concept.
Osteria Tulia opened for dinner Jan. 11, 2013, at 466 Fifth Ave. S. in downtown Naples. The local restaurant is operated by Chef Vincenzo Betulia.
Naples Bay Resort is reflected in one of the windows of Mereday's, a fine-dining restaurant that opened there on July 26, 2013.
HobNob Kitchen & Bar opened for dinner Monday, Dec. 16, 2013, in the Ingram Building at 720 Fifth Ave. S. in downtown Naples.
Nana's Diner reopened as Nana's in the Santa Barbara Plaza on the corner of Santa Barbara Boulevard and Golden Gate Parkway on Oct. 18, 2013, in Golden Gate. The restaurant's original location on Collier Boulevard was gutted by fire on Aug. 27.
Erin's Isle Irish Pub reopened Jan. 7, 2013, in the former Bogey's Bar & Grill at Hibiscus Golf Club, a public golf course located off Rattlesnake Hammock Road in East Naples.
Amador's on the Green opened Oct. 9, 2013, in Lakewood Country Club of Naples, 4235 Lakewood Blvd., East Naples.
Tewksbury's opened Aug. 14 in the longtime former home of Bernard's at the Royal Wood Golf Club in East Naples.
Gatsby's Pizza opened Jan. 29, 2013, in its new location at 4450 Bonita Beach Road in Bonita Springs.
Chuck E. Cheese's opened its first Collier County location in September 2013 in the Granada Shoppes, 1000 Immokalee Road, North Naples.
Culver's, a Wisconsin-based casual restaurant chain known for its ButterBurgers and frozen custard, opened its first Florida location Sept. 16, 2013, on Airport-Pulling Road in North Naples. It followed up with its first Lee County location, which opened Dec. 16 in University Plaza, adjacent to Gulf Coast Town Center in south Fort Myers.
Buffalo Wild Wings opened in March 2013 in Courthouse Shadows shopping center in East Naples.
Buffalo Wild Wings opened Nov. 25, 2013, in the former Stevie Tomato's and Rib City Grill location in Prado at Spring Creek shopping center on U.S. 41 in Bonita Springs.
Cloyde's Steak & Lobster House, a 25-year-old waterfront restaurant at the Village at Venetian Bay, changed hands in July 2013 and was renamed T-Michaels Steak & Lobster House.
Cafe Luna opened its second area location Nov. 14, 2013, in Sugden Park Plaza off U.S. 41 East. The red-and-white-striped awnings of the former Boston's Restaurant & Sports Bar are now bright blue.
Komoon Thai Sushi & Ceviche opened a second location July 15, 2013, in the Center of Bonita Springs, the Publix-anchored shopping center on the northwest corner of U.S. 41 and Bonita Beach Road.
Salado Pedro's, a Veracruz-style cantina and tequila bar, opened July 8, 2013, in Gulf Coast Town Center in south Fort Myers.
Skillets opened its fourth area location Jan. 10, 2013, in the former North Naples location of Bha! Bha! Persian Bistro in The Pavilion shopping center, located on the northwest corner of Vanderbilt Beach Road and U.S. 41 North.
The Pelican Larry's Raw Bar & Grill location in Uptown Center off Immokalee Road in North Naples became Rusty's Raw Bar & Grill in 2013. So did the two Uptown Larry's locations in Lee County, effective June 1, 2013.
Mr. Big Fish seafood restaurant opened Feb. 10, 2013, in the former Tropical Palm Cafe space in Neapolitan Way shopping center off U.S. 41 North in Naples.
Grouper Grille opened in September 2013 in the former location of Falafel Grill in an L-shaped strip center at 2075 Pine Ridge Road in North Naples.
The Wine Loft wine bar opened in January beneath the Silverspot Cinema in Mercato in North Naples.
Taps Restaurant, Bar & Lounge opened in July 2013 in Mercato's piazza near The Second Cup and The Counter burger bar.
Second Cup coffee cafe opened July 15, 2013, in a freestanding building in the center of Mercato in North Naples.
Manzanillo's Cocina Mexicana opened Oct. 7, 2013, in Royal Cove Plaza, 13240 U.S. 41 N., North Naples. The nearly 6,000-square-foot space formerly was EVOO Market.
Tacos & Tequila Cantina opened Aug. 19, 2013, at 4834 Davis Blvd. in the Kings Lake Square shopping center in East Naples.
Mr. Tequila Mexican Bar & Grill opened a second location in the Naples area on Dec. 23 in the former home of Blue Agave in Naples Towne Centre in East Naples.
Ford's Garage opened its third location in the fall of 2013 in the former home of Tipsy Tarpon Seafood Shack at the eastern end of Miromar Outlets in Estero.
Sumo Sushi Sake, the first sushi drive-thru restaurant in Naples, opened Feb. 25, 2013, in The Promenade at Naples Centre, 6438 Naples Blvd., at Airport-Pulling Road, in North Naples.
Joey D's Italian Restaurant opened its second location May 7, 2013, in Brooks Village, the Publix-anchored shopping center on the southwest corner of Pine Ridge Road and Collier Boulevard.
La Cuisine Peruvian restaurant opened Oct. 5, 2013, in Naples Towne Centre, 3861 U.S. 41 E., East Naples. The new restaurant moved into the former home of Machu Picchu Peruvian restaurant.
Arthur and Dale Stoerchle opened Black Forest Mill Restaurant on Sept. 3, 2013, in the Green Tree Center at Airport-Pulling and Immokalee roads in North Naples.
Stephan's German Bistro opened in October 2013 in the Prado at Spring Creek shopping center in Bonita Springs.
Restaurant Bonjour opened May 1, 2013, in the former North Naples home of Mimi's Cooking and Paul's Donuts & Cafe, 2099 Pine Ridge Road.
Café Chic opened its first of two Naples locations in August 2013 in The Village on Venetian Bay, 4200 Gulfshore Blvd. N., suite 506.
The second Naples location of Cafe Chic opened in October 2013 at 635 Eighth St. S., the former location of Trixie's Torpedo Sandwiches across from Cambier Park.
Burger 21 opened Dec. 16, 2013, in Gulf Coast Town Center in south Fort Myers. The fast-casual "better burger" franchise took the former space of Elevation Burger.
Terrazza, formerly The Terrace restaurant, opened in November 2013 during a major renovation at Ritz-Carlton, Naples.
Patinella's Chicken Grill opened in November 2013 in the former home of China Express in Piper's Crossing in North Naples.
Kitchen 41 opened Aug. 26, 2013, in Plaza Walk on U.S. 41 in Naples.
Fuse Global Cuisine opened Nov. 15, 2013, in Plaza Walk at 2500 U.S. 41 N. in Naples.
Hibachi of Japan opened Nov. 13, 2013, in Pebblebrooke Center, located off Collier Boulevard near Immokalee Road.
Khwan Sawai and Adam Satinsky debuted their Thai Udon Cafe on Aug. 5, 2013, in Magnolia Square on the northeast corner of Goodlette-Frank and Pine Ridge roads in North Naples.
Marco Prime Steaks & Seafood opened Aug. 28, 2013, in the former space of Konrad's in Marco Walk Plaza off Collier Boulevard on Marco Island.
La Morenita Mexican Restaurant opened in July 2013 in the former location of formerly Tortilleria La Frontera, 19630 U.S. 41 S., San Carlos Park.
Marco's Pizza, a franchise of the Toledo, Ohio-based chain, opened Feb. 12, 2013, in Collier Plaza, 11985 Collier Blvd., Golden Gate.
Pizza Fusion opened Aug. 30, 2013, next to Thoughtful Threads in The Gateway of Naples shopping center, 2146 U.S. 41 N., just west of Naples High School.
Altavilla Pizza and Deli opened Sept. 27, 2013, in the Sweetbay-anchored Mission Hills Shopping Center, 7550 Mission Hills Drive, on the corner of Collier Boulevard and Vanderbilt Beach Road in North Naples.
Lil Italy Bistro opened May 15, 2013, at 28811 U.S. 41 S., next to Capriotti's Sandwich Shop, just north of the Lee-Collier county line, in Bonita Springs.
Saladworks opened July 1, 2013, in Riverchase Plaza on the northeast corner of U.S. 41 and Immokalee Road in North Naples.
Maria D'anna Cafe opened in January 2013 in Trinity Plaza on the corner of Ninth Street North and Third Avenue North in Naples.
The new Whisk Bakery and Sandwich opened Thursday, Dec. 12, 2013, next to Richie's Restaurant on Third Avenue North in Naples.
Royale Cafe Vinoteca opened in January 2013 in downtown Naples. The café is open for breakfast and lunch in the Contessa building, 180 9th St. S., suite 100.
Veranda E opened in February 2013 for dinner in the former location of Dish restaurant in The Escalante hotel, 290 Fifth Ave. S., in Old Naples. Courtyard dining extends from the hotel outward and past the pool.
Pho Dai Loc Vietnamese Cafe opened in April 2013 in Collier Plaza, off Collier Boulevard in Golden Gate.
In early December 2013, The Swiss Diner replaced Chrissy B's in Tanglewood Market Place on U.S. 41 North in North Naples.
China One recently opened in the former space of Chopsticks Chinese Take-out in River Reach Plaza, 1248 Airport-Pulling Road N., East Naples.
Petit Soleil, an offshoot of Bistro Soleil, opened in May 2013 in The Shops of Olde Marco on Palm Street on Marco Island.
Pollo Tropical opened March 8, 2013, at in Gulf Coast Town Center, 17804 Ben Hill Griffin Parkway, in south Fort Myers.
The first area drive-thru location of Little Caesars Pizza opened May 7, 2013, on Golden Gate Parkway in Golden Gate.
Truly Organic Pizza opened in August 2013 in the Cohen Center food court at Florida Gulf Coast University in Dunk City.
Smokin R's BBQ opened in early March inside E's Country Store on the corner of Wilson and Golden Gate boulevards in Golden Gate Estates.
House of Brewz Taps & Tapas opened in November 2013 in the former home of Eastside Firepit City Grill in Gulf Coast Town Center in south Fort Myers.
Dylan's Draft House opened in early October, replacing Zookie's Too Sports Pub in River Reach Plaza, 1258 Airport-Pulling Road N., East Naples.
Patrons enter Delicious Raw Juice Bar on July 30, 2013, in Naples. The business opened in June, serving up non-additive all-natural juice drinks and smoothies. Co-owners Flemming Madsen and his wife, Gitte, had been visiting Naples for the last 20 years from their native Denmark and figured it was time to lay down roots in the area.
Green Cone Café opened Nov. 27, 2013, next to the movie theater in Bonita Springs' Prado at Spring Creek shopping center off U.S. 41.
Uncle Louie G's Italian Ices & Ice Cream opened May 9, 2013, in Berkshire Commons, 7385 Radio Road, at Santa Barbara Boulevard, in East Naples.
Orange Leaf Frozen Yogurt opened May 14, 2013, in Riverchase Plaza on the northeast corner of U.S. 41 and Immokalee Road in North Naples.
Big Block Sub Shop opened July 1, 2013, at 27792 Old 41 Road, on the corner of Tennessee Street, in Bonita Springs.
Subway opened a location in July 2013 in Pebblebrooke Center, 15215 Collier Blvd., near Immokalee Road and next to Gino's Trattoria Per Tutti Italian restaurant, right.
The long-awaited Dunkin' Donuts in East Naples opened in September 2013 in Courthouse Shadows shopping center off U.S. 41 East.
Dunkin' Donuts opened a new North Naples location in September 2013 on the northeast corner of Livingston and Immokalee roads in the outparcel space in front of the former Albertsons supermarket. The nearby Dunkin' store closed Sept. 2 next to CiCi's Pizza in Uptown Center
Starbucks opened a new drive-thru location Aug. 24, 2013, in Riverchase Plaza on the northeast corner of U.S. 41 and Immokalee Road in North Naples.
Le Macaron French Pastries opened April 28, 2013, near Grace & Shelly's Cupcakes in Mercato in North Naples.
Sweet Odin's Danish Bakery opened March 25, 2013, in the former Bonita Springs location of HoneyBaked Ham in Pelican Village shopping center at the entrance to Pelican Landing.
The Courtyard Bar at Ridgway opened in October 2013 in the courtyard adjacent to Ridgway Bar & Grill and Tony's Off Third, 1300 Third St. S., which faces 13th Avenue South in downtown Naples.
Old Fogies opened in February 2013 at 26455 Old 41 Road, in the Shoppes at Hawthorne, just north of Buffalo Chips Restaurant in Bonita Springs.


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WASHINGTON, DC (WUSA9)-- Actors Glenn Close and Bradley Cooper were at the White House today, adding some celebrity buzz to an issue they both champion: mental health treatment and the eradication of stigma that may still surround it.
They helped President Barack Obama kick-off a conference on the nation's mental health; the President says the time has come to bring the issue "out of the shadows."
"We see commercials on TV about a whole array of physical problems, some of them very personal. People laugh and yet we whisper about mental health issues," the President said.
Cooper has been promoting mental health awareness since his Oscar-nominated leading role as a man with bipolar disorder in last year's "Silver Linings Playbook."
Glenn Close's sister and nephew have both been diagnosed with mental health disorders; she calls it "a family affair."
Close said, "The amount of gifts of talent that we are losing because we are not taking care of people with mental illness is catastrophic."
President Obama pushed for a new focus on mental health treatment, as well as gun control, after the massacre at Sandy Hook Elementary School in Newtown, Connecticut. But the White Houe also stressed that the majority of people with mental health conditions are not violent, and are more likely to be victims rather than perpetrators of crimes.
Beginning next year, under the Affordable Care Act, people with existing mental illnesses can't be denied health insurance coverage. President Obama's 2014 budget also calls for $130 million to help train educators to recognize early signs of mental illness in students.
Depression and suicidal thoughts can be particularly dangerous in teenagers; therapists say adolescents often have a hard time seeing a future beyond their immediate, overwhelming despair. In the last few weeks, two students at Montgomery County, Maryland high schools have taken their own lives.
"We know that it is often our young people who are at risk," says licensed clinical psychologist Barbara Van Dahlen, PhD
Dr. Barbara VanDahlen says parents, teachers, and peers need to reach out and offer help to a person who may be showing signs of worsening depression, hopelessness, and loss of interest in daily activities. She says many suicides can be prevented if the warning signs are recognized.
Van Dahlen also created an organization called "Give An Hour", which offers free counseling to another vulnerable population, our military service members, veterans and their families.
"It is this wonderful clearinghouse of mental health professionals willing to give an hour of their time to those who come home, and their families," says Van Dahlen.
"They go to our website, which is GiveAnHour.org and put in their zip code, and immediately see who (is available) in their area."
Van Dahlen recently wrote an article for Time magazine entitled"Our Shared Mission... to End Suicide". She also took part in the White House mental health conference today.
If you need to talk to someone right now, The National Suicide Prevention Lifeline number is:


text: Prince Williams, Getty Images [ Jay-Z's Roc Nation Partners with Universal Music Group By Paul Cantor April 8, 2013 Jay-Z's fledgling management firm/record label Roc Nation is partnering with Universal Music Group in a multi-year deal, it was announced today (April 8)... Read More Category: Hip-Hop Tags: Jay-Z, major record labels, MajorRecordLabels, rappers and sports, RappersAndSports, robinson cano, RobinsonCano, roc nation, roc nation label, roc nation record label, roc nation sports, RocNation, RocNationLabel, RocNationRecordLabel, RocNationSports, signed to roc nation, SignedToRocNation, sports agency, SportsAgency, universal music, universalmusic, victor cruz, VictorCruz, who is signed to roc nation, WhoIsSignedToRocNation Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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- Northern New York Newspapers
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CARTHAGE Unselfishness and balanced scoring have fit together nicely for the high-flying Carthage boys basketball team.
Sharing the ball has made the Comets offense very efficient. And the fact that all five starters have led the team in scoring at least once this year makes them hard to defend.
Tuesday nights 66-48 Frontier League A Division win over Indian River was just the latest example of why coach Jeff Ventiquattros club has won nine straight games, and clinched at least a share of the division title with the victory. Four players hit double figures, led by sophomore Peyton McLaurin with 17 points, as Carthage (12-1 overall, 8-1 league) pulled away in the second half after holding a tenuous two-point halftime lead.
Its nice to know that one or two guys dont have to carry the load, and that everybody can contribute, said Carthage junior forward Walter Jeter, who scored 14 points and hauled down 15 big rebounds. It makes you want to make that extra pass to find the open guy because you know its going to be an easier basket.
Junior Keyan Pinnock added 13 points, the lone senior, Ben Martin, contributed 11 points and eight rebounds, and junior Andrew Smith hit for nine points for Carthage, ranked 25th in the state in Class A this week.
Ventiquattro knows he has something special in this cohesive group.
The two big guys (Martin, Jeter) are controlling the inside, Keyan has given us another dimension with his ability to get to the basket, Peyton is learning how to score besides making 3-pointers, and Andrew just a lot of little things to help us win, Ventiquattro said. And for the most part, our defense has been really good. Tonights second half defensive effort was a really gritty performance.
The Warriors (7-4, 6-4) hung around the first half because they worked the ball inside the Carthage 2-3 zone, attacked the boards and got enough easy buckets to stay within 26-24 at halftime.
But Carthage took away the inside scoring the second half, allowing just nine points in the third quarter, while the Comets offense generated 21 points to take a 47-33 lead.
All the things we did well the first half to be in the game we didnt do the second half, said Indian River coach Tim Callahan. And every mistake we made, they made us pay.
Jeter hit a 3-pointer and two inside hoops, Smith had a 3-pointer and a driving bucket, and Martin a follow shot over the final four minutes of the third quarter as Carthage outscored Indian River 13-4.
Martin then scored six consecutive points to begin the fourth quarter, and the Warriors managed just two points in the opening four minutes of the period.
In the tunnel at halftime we talked about playing better defense the third quarter and not allowing them to score so easily, said Jeter, one of three starters averaging in double figures. Our defense has been solid all season, even when the offense is not clicking.
Junior Shelton Williams, who led all scorers with 25 points, was the only consistent offensive force for Indian River.
Malik Tillman scored six first-quarter points, but did not score after that. And sharpshooting Justin Mattingly had a rough game from the 3-point line, going just 3 of 12.
We need a couple of other guys to step up and help Shelton, Callahan said. Thats what makes Carthage so tough. Theyve five guys who can score on a consistent basis.
Ventiquattro said for Carthage to take the next step in its progress a long run in the sectionals the Comets must be able to handle the physical defenses well see and do an even better job rebounding and on the boards.
Said Jeter: I dont think weve even come close to our potential, so I see us getting even better before the season is over.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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Marjan The Lion Unveiled At Kabul Zoo
Afghanistan-unrest-animal-lion,FOCUS by Sardar Ahmad This photo taken... ニュース写真アフガニスタン,カブール,ヒューマンインタレスト,住宅,写真,動物,動物の世界,動物の子供,屋根,座る,横長,飼育動物Photographer AFPCollection: AFP 2014 AFPTO GO WITH Afghanistan-unrest-animal-lion,FOCUS by Sardar Ahmad This photo taken on June 5, 2013 shows a six month-old lion sitting in the sun on a rooftop of a residential neighbourhood in central Kabul. Lying on a rooftop terrace in a residential neighbourhood of central Kabul is one of the world's least suitable domestic pets -- a fast-growing lion cub. The animal, which does not have a name, lives on top of a building in the district of Taimani, surrounded by high walls and fences, and is fed every day by an attendant who throws it raw meat. AFP PHOTO / Daud Yardost (Photo credit should read DAUD YARDOST/AFP/Getty Images)


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Ok people,who is the next target (my vote IRAN) do we have more lucrative targets ?
I don't know really, I don't know if we'll choose a next target. Our congress isn't nearly as gung ho as they were a few weeks ago about spreading this war out. Which I think is a crying shame, but that is just me!
If you give a man a fire he'll be warm, if you light the man on fire he'll be warm for life.


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To the Sea (Alamar)
A gently-told blend of documentary and fiction, this highly acclaimed and already multi-award-winning work follows the last summer little Natan will spend with his father in Mexico before a move to Rome. Off the coral reef of Banco Chinchorro, the boy learns about the land and water around him, guided by his father and grandfather. This is poetic filmmaking that foregrounds the peace and beauty of a fragile environment.
Cast: Natan Machad Palombini, Néstor Marín "Matraca", Roberta Palombini, Jorge Machado
Produced by:
Directed by: Pedro González-Rubio
Written by:
Running time: 1hr 13min
|Theaters for Today
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Events and Activities at Lied Lodge
Apples Ready for Picking
At Arbor Day Farm
Arbor Day Farm's you-pick orchards are NOW OPEN for the season with select varieties ready to pick.
Download the Fall Season PDF Brochure and make the most of your fall visit to Arbor Day Farm.
- Pick over 15 varieties of apples in the orchard
- Or... buy them by the bag or bushel in the Apple House Market
- Enjoy caramel apples, apple pies, and apple cider pressed on-site
- Tour the Preservation Orchard — a unique collection of heirloom apple trees with fruit that is no longer commercially available
- Climb aboard a hayrack ride to the orchard
- Zig-zag your way through the corn maze
- In October: find the perfect pumpkin in the patch
Living History Weekends
At Arbor Lodge State Historical Park
It's a time-honored tradition at Arbor Lodge State Historical Park: Living History Weekends — back this fall season for the 35th year.
Visit Arbor Lodge on Sundays this fall -- 10am to 6pm -- and step back in time to see the trades, talents, and other demonstrations come alive inside the mansion and out on the beautiful grounds of Nebraska City's National Historic Landmark.
- September 27: Back to Nature
Basket weaving, nature crafts, cider pressing, dancing horses.
- October 4: Heritage Day
Traditional folk music, harmonica lessons, bagpipes, cultural information and demonstrations, weaving, lacemaking.
- October 11: Rendezvous
Mountain Man encampment, Dutch oven cooking, china painting, dulcimer playing, horse care and training.
- October 18: Victorian Times
Old-time clothing and medicine, vintage fan collection, fan making, cider pressing, pottery.
- October 25: Vintage Halloween
Hat making, painting, leather crafting, Halloween decor/history.
Questions about Living History Weekends? Please call the mansion: (402) 873-7222.
Admission to the park is free and no longer requires a park entry permit; mansion admission is $7 adults, $4 youth (age 3-12).
Hayrack Rides, Cider & S'mores
At Arbor Day Farm
Weekends this fall, the entire family will enjoy a mash-up of Arbor Day Farm's most beloved fall season activities: hayrack rides, cider, s'mores and storytelling!
On select Friday and Saturday nights in October and November, climb aboard a hayrack at the Lied Lodge lobby, where your journey begins at 7:00pm sharp. Travel to Arbor Day Farm's Morton Oak tree, where you'll sip hot apple cider, make s'mores, and enjoy tales from a storyteller, then return to Lied Lodge by approximately 8:45pm.
Tickets are $12.50+ tax for adults; $10+ tax for children, age 3-12. Seating is limited on the hayrack, and this activity often sells out. To reserve your seat, please call Lied Lodge at 800-546-5433.
Want to make it a getaway? The Hayrack, Cider & S'mores Package includes an overnight stay at the all-new Lied Lodge plus up to four (4) tickets for the hayrack ride activity; availability is limited, so please call to reserve: 800-546-5433.
Remaining October hayrack dates available: Oct. 23-24, 30-31.
November hayrack dates: Nov. 6, 13, and 14.
No-Scare Halloween Fun
At Arbor Day Farm Tree Adventure and Arbor Lodge State Historical Park
We're celebrating no-scare Halloween fun at the Tree Adventure and Arbor Lodge State Historical Park, and you're invited!
This special pumpkin party is rain or shine, 9am to 5pm, and included with regular admission. All ages welcome to come in costume and enjoy:
- Hayrack rides to the pumpkin patch
- Face painting at the treehouse
- Pumpkin decorating with help from Tree Adventure staff
- Make-and-take Halloween crafts
- Halloween Hunt along the trails - use "spooky clues" to find fun items in the forest
Arbor Day Farm's Discovery Ride will also be running during the pumpkin party, with rides on the hour from 11am-4pm. Discovery Ride admission is $4 for adults; $3 for children.
Celebrate fall at Arbor Day Farm Tree Adventure! More details coming soon; questions: (402) 873-8717
Grand Thanksgiving Buffet
At Timber Dining Room at Lied Lodge
A delectable buffet dinner in beautifully inspiring surroundings… that's the Grand Thanksgiving Buffet at Lied Lodge & Conference Center. Leave the details — and the dishes! — to us and enjoy a scrumptious holiday experience with your friends and family.
The Grand Thanksgiving Buffet is served Thursday, Nov. 26, from 11am to 2:30pm.
View the Lied Lodge Thanksgiving Menu and then call for your reservation: 800-546-5433.
Holiday Trolley Tour of Lights
At Lied Lodge & Conference Center
Back by popular demand — it's the Holiday Trolley Tour of Lights in Nebraska City.
Weekends this December, climb aboard the Arbor Day Farm trolley for a one-hour tour of Historic Nebraska City and the best show of Christmas lights.
During the ride, you'll enjoy a reading of the classic Christmas book, The Polar Express.
The trolley departs the Lied Lodge lobby at 7:00pm sharp and returns approximately one hour later.
Price is $12.50 + tax for adults; $10 + tax for children age 3-12. Under three's ride for free.
2015 Holiday Trolley Tour Dates:
December 4 & 5
December 11 & 12
December 18 & 19
December 25 & 26
This popular activity fills up quickly, so reserve your seats on the holiday trolley by calling Lied Lodge: 402-873-8733.
*Want to make it a memorable holiday getaway? Ask for the Holiday Trolley Tour Package, which includes the trolley ride / tour of lights listed above for up to four people, plus an overnight stay at the all-new Lied Lodge. Please call to reserve: 800-546-5433.
Brunch with Santa
At Lied Lodge & Conference Center
One of Santa's favorite stops is at Lied Lodge in Nebraska City. Bring your children (and their wish lists) for this holiday tradition and enjoy live Christmas tunes on our grand piano, along with very special "child friendly" Sunday Brunch Buffet selections in the Timber Dining Room.
Brunch with Santa is served 11am to 2pm on December 6, December 13, and December 20. We'll also be collecting canned food items for the Nebraska City Food Bank; all non-perishable items are welcome.
For brunch reservations, please call: 402-873-8740, or reserve a table online here.
New Year's Eve — Getaway & Concert
At Lied Lodge & Conference Center
Ring in the new year at Lied Lodge! This popular year-end package includes:
- an overnight stay at the all-new Lied Lodge on Thursday, December 31st
- grand buffet dinner for two in the Timber Dining Room
- two tickets for live band High Heel in Concert (8:30pm-12:30am)
- a midnight champagne toast and party favors
- breakfast buffet for two the next morning in the Timber Dining Room.
Reserve your New Year's Getaway for $329 + tax; please call 800-546-5433 to reserve.
Want to enjoy the High Heel concert without staying over? Concert tickets are available at the door for $20 + tax.
Morton Mansion at Arbor Lodge
At Arbor Lodge State Historical Park
Step back in time and be inspired for tomorrow at Arbor Lodge State Historical Park in Nebraska City. Tour the 52-room mansion, loaded with family artifacts and mementos from J. Sterling Morton, the founder of Arbor Day, the tree planter's holiday first established in 1872.
Also on the grounds: a carriage house and tack room, Monument Square, a whispering bench, 200+ varieties of lilacs from around the globe, a playground, picnic areas, and other trails. Park is open daily; park permit is NOT required for access. Admission applies for mansion access. Questions? Please call (402) 873-7222.
Arbor Lodge State Historical Park is owned by Nebraska Game & Parks Commission, and is managed by the Arbor Day Foundation.
Tree Adventure at Arbor Day Farm
At The Tree Adventure
Discover something new every season at Arbor Day Farm Tree Adventure. Here you can hike miles of forested trails, climb a 50-foot-tall treehouse, embark on the guided Discovery Ride, and play and learn in the Nature Explore Classroom. Your paid admission includes a tree seedling to plant at home. The Arbor Day Farm experience isn't complete until you've explored the many activities at the Tree Adventure. Open daily. Photo: R. Neibel.
The Timber Dining Room at Lied Lodge
At Lied Lodge & Conference Center
Open for breakfast, lunch and dinner, enjoy nature-inspired cuisine made with locally-grown ingredients in the Timber Dining Room. Choose from seafood, Nebraska steaks, buffalo, vegetarian options, an extensive wine list featuring Arbor Day Farm signature wines, and a decadent dessert menu. Children's menu also available. For reservations, call 402-873-8740, and find complete menu selections on our dining page.
Olympic-sized indoor pool at Lied Lodge
At Lied Lodge & Conference Center
Whether you swim laps or just splash around, all guests are welcome in the olympic-sized indoor pool. Take a relaxing soak in the Jacuzzi or steam away stress in the red cedar sauna. Young swimmers will appreciate the separate baby pool, just 18" deep. The pool is open daily from 6:30am to 11:00pm, and is reserved exclusively for Lied Lodge guests.
The Lied Greenhouse at Arbor Day Farm
Tour the state-of-the-art growing facilities where many thousands of tree seedlings flourish at Arbor Day Farm. Learn about the important role you play in the Arbor Day Foundation's tree planting mission and, in peak season, watch as thousands of tree seedlings are sorted, labeled, boxed and shipped to destinations around the world. Access to the Lied Greenhouse is included with your Tree Adventure admission. More about the Lied Greenhouse.
Discovery Ride
At Arbor Day Farm Tree Adventure
All aboard for a front row view of nature! Embark on the Discovery Ride, an hour-long guided journey deep into the forest at Arbor Day Farm Tree Adventure. Travel over the creekbed and through the orchards while an experienced tour guide shows and tells all about the rich history and bright future of these 260 acres. A great way to take your team outdoors for a group activity.
Current ride times and admission prices.
The Discovery Ride is also available for private bookings. Contact us and we'll coordinate a ride time that works for you.
Spa Treatments
At Lied Lodge & Conference Center
Relax, rejuvenate, and refocus in the Spa at Lied Lodge. Choose from a full menu of massages and body therapies to soothe away stress and leave you feeling renewed. View the spa menu here, or request a spa appointment online, and treat yourself the way nature intended.
The Apple House Market
The Apple House Market is your one-stop shop for Arbor Day Farm's freshest seasonal fruits and vegetables, signature wines, fudge, fresh-baked pies, light lunch entrees, and unique gifts. Within walking distance of Arbor Day Farm Tree Adventure and Lied Lodge & Conference Center, the Apple House Market is open daily. Apple House Market phone: (402) 873-8710.
Wine, Cheese, and a Walk Among the Trees
Wine, Cheese & A Walk Among the Trees is a relaxing food & nature activity at Arbor Day Farm Tree Adventure. Start with a glass of Arbor Day Farm wine and snack on assorted cheeses; then head out to the wooded trails for a casual stroll-and-learn with Arbor Day Farm tree experts.
- Allow 1-2 hours for this activity
- Minimum of 25 people; maximum of 100 people
- $30 per person
- Available June through October
- Request this activity now, or call (402) 873-8705
Arbor Day Farm Guided Tour
Enhance your visit to Arbor Day Farm with an engaging Nature Interpreter who shares the history of this 260-acre National Historic Landmark. The tour begins at Lied Lodge, then includes a look inside the Fuelwood Energy Plant, and concludes with a walk to the Tree Adventure. Available year round.
- Guided time is 2 hours; attendees may then explore at their leisure.
- 15 to 25 people per guide. Smaller or larger groups, please call.
- $15 per person, age 13 and older ($19 when you include the Discovery Ride)
- $13 per person, age 3-12 ($16 when you include the Discovery Ride).
- Tree Adventure admission is included.
- Request this activity now or call to reserve: (402) 873-8705.
Discovery Ride
Climb aboard and embark on a guided tour into the heart of the orchards and forest. See and learn about Arbor Day Farm's conservation practices at work. 25 adults approximate capacity. Rides offered April through October.
- Rides last approximately one hour.
- Private Discovery Rides available. Call 402-873-8705 to schedule.
- Tree Adventure admission plus $4.00 per person age 13 and older, $3.00 per person ages 3-12.
- Request this activity now or call to reserve: (402) 873-8705.
Twilight Discovery Ride
Your group will enjoy a private, enchanting guided Discovery Ride through the orchards and forest at sundown as the magnificent colors of sunset cast a spectacular glow across Arbor Day Farm. Available April through October. 25 adults approx. capacity.
- Twilight rides last approximately one hour.
- $15 per person, age 13 and older , $11 per person, age 12 and younger
- Minimum of 15 people; 25 people maximum.
- Tree Adventure admission is included.
- Request this activity now or call to reserve: (402) 873-8705.
Gnome Hunt - Group Favorite!
Find the forest gnomes climbing trees and hiding in the brush. Using clues and a map, looking high and low, the hunt is on. Available year round.
- Gnome Hunt lasts approximately 1 - 1.5 hours.
- $7 per person, age 13 and older; $5 per person, age 12 and younger.
- Set up charge of $100 for groups up to 50 people.
- Minimum of 15 people per group.
- A great rain-or-shine activity.
- Request this activity now or call to reserve: (402) 873-8705.
Sunset & S'mores
Share in a summer evening treat at the Tree Adventure! Climb aboard for a guided, one-hour Sunset Discovery Ride as you journey through the orchards and vineyards at Arbor Day Farm. Following the ride, gather 'round for a twilight bonfire complete with make-your-own s'mores.
- Allow two hours for this activity
- 15 to 25 people. Smaller or larger groups, please call.
- Ride departs approximately one hour before sunset
- $19 per adult; $15 per child (age 3-12)
- Price includes admission for the Tree Adventure, ticket for the Discovery Ride, s'mores, and beverage
- Request this activity now or call to reserve: (402) 873-8705
Fuelwood Energy Plant Tour
Visit the Fuelwood Energy Plant, a renewable biomass energy operation that uses trees and technology to heat and cool Lied Lodge & Conference Center at Arbor Day Farm. Featuring interpretive panels and interactive exhibits, and hosted by an experienced Arbor Day Farm Nature Interpreter. Available year round. Watch a short video about the Fuelwood Energy Plant.
- Tour lasts approximately one hour.
- Meets at Lied Lodge.
- $5 per person.
- $75 for groups fewer than 15.
- Tree Adventure admission is not required.
- Request this activity now or call to reserve: (402) 873-8705.
Private Bonfire
Enjoy the evening stars at Arbor Day Farm as your group unwinds around a big, mesmerizing bonfire out in the open air. Available year round.
- Bonfire lasts approximately 1-3 hours
- Set up charge of $150 for the first hour; $75 for each additional hour.
- Children must be accompanied by adults.
- S'mores and a storyteller may be added for an additional fee; ask for details.
- Tree Adventure admission is not required.
- Request this activity now or call to reserve: (402) 873-8705.
Arbor Lodge Mansion Tour
Arbor Lodge is the original estate of J. Sterling Morton -- the founder of Arbor Day, the tree planter's holiday. What started as a four-room home evolved into the 52-room mansion that still stands today. The home is filled with priceless artifacts of the Morton Family's life and legacy; you will be impressed.
- Allow 1-2 hours for mansion tours
- Tour begins with five-minute introduction, followed by a 10-minute video; visitors can then explore the mansion at their leisure.
- Adults: $7, youth (age 4-12) $5
- Request this activity now or call (402) 873-8705
Tree Sleuth
Learn to identify and classify trees by their leaf shape, structure, seeds, fruit, and leaves.
- Tree identification activity lasts about one hour.
- $15 per person; minimum of 15 people
- Includes a What Tree is That? 76-page tree ID field guide for each participant to keep
- Request this activity now, or call to reserve: (402) 873-8705
Commemorative Tree Planting
Commemorate your event or a special occasion by planting your own tree at Arbor Day Farm. The ceremony includes a tree (ranging 4-feet to 7-feet tall) -- choose from 67 different species -- with a small plaque describing the tree and the person or event being honored. Shovels and mulch provided. The arborist team at Arbor Day Farm will provide ongoing care for your living monument. Available April through October.
- Ceremony and tree planting last approximately 30 minutes.
- Set-up fee of $500-$800.
- Request this activity now or call to reserve: (402) 873-8705.
Welcome Presentation
Lied Lodge and Arbor Day Farm is a bustling place -- and this 15-minute welcome presentation from one of our employees gives you an overview of who we are, what we do, and the global impact of our tree-planting mission. Takes place in your meeting room; includes PowerPoint. Complimentary.
Wine Tasting
The vineyards at Arbor Day Farm bring forth several varietals of red, white, and fruit wines. Find your new favorite with our wine tasting activity.
- Allow 15-30 minutes
- Participants select any four tastes (1 oz. each) of Arbor Day Farm wines; the wine glass is theirs to keep.
- $6 per person; must be age 21.
- Available year round.
- Request this activity now, or call to reserve: (402) 873-8705
Mixology Class
This fun, interactive session is your opportunity to build some bartending skills, courtesy of the Lied Lodge bartending staff. Learn how four different specialty drinks are made, then taste-test what you've learned.
- 10-50 people per class; minimum of 15 people.
- $10 per person, includes samples of the specialty drinks
- Set up fee of $75
- Reserve this activity now, or call (402) 873-8705
Bees & Blossoms
An Arbor Day Farm Nature Interpreter delves into a closer look at the fascinating -- and important -- lives of bees in the orchard and beyond. This activity is an introduction to the way bees "communicate" -- including their special dance; includes a visit to the hive in the Exploratory Cabin at Arbor Day Farm Tree Adventure.
- Bees and Blossoms activity last approximately one hour
- 15-25 people per Nature Interpreter
- Adults, $12; Children $10
- Request this activity now, or call (402) 873-8705
Golf at ArborLinks
Guests of Lied Lodge & Conference Center are given exclusive 'members-only' privileges at ArborLinks Golf Course in Nebraska City. Golfers will appreciate the natural beauty and the challenge of this 18-hole, 320-acre championship golf course designed by legend Arnold Palmer. To make golf arrangements for your group, please visit with your meeting planner or call (402) 873-8705.
Canvas Painting Session
Get your creative juices flowing with a canvas painting activity at the Apple House Market, one of the retail shops at Arbor Day Farm. Sip a glass of Arbor Day Farm wine and join your colleagues in painting individual 16"x20" canvasses with the guidance of a local artist; all materials provided and the art is yours to keep. The perfect creative outlet for those seeking something new and different -- makes a great team building activity. Shop the Apple House Market before and after your session, too.
- Allow two hours for this activity
- Minimum of 25 people
- $38 per person plus tax and service charge
- Reserve this activity now, or call to reserve: (402) 873-8705


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- Earn 1 point for every $1 in purchases charged to the Card. Plus, you can earn 1 extra point for every $1 in eligible purchases charged to the Card at 3 suppliers you pick from a list of select American Express merchants in Canada. You can earn up to a maximum of 250,000 extra points in each calendar year2.
- Enjoy rewards flexibility that makes your business spending work for you. Use your points to:
Offset Business Expenses with PointFlex for BusinessTM3 You have the option to redeem points for statement credits to offset eligible purchases charged to your Card at certain American Express Merchants in Canada. These merchants provide goods and services in business categories such as equipment, technology, advertising and everyday business expenses. 12,500 points = $100 PointFlex for Business statement credit.
Offset Trip Expenses with TripFlexTM rewards1 You can also redeem points through TripFlex rewards to offset eligible travel purchases charged to the Card. Simply charge eligible travel purchases to your Card then pay for it with points (including taxes and fees). 10,000 points = $100 TripFlex rewards statement credit.
- Earn a Welcome Bonus of 30,000 points when you charge $5,000 in purchases to your Card in your first three months of Cardmembership.9That's enough to redeem for a $300 TripFlex™ rewards statement credit to use towards eligible travel purchases charged to your Card.1


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Experts from the Massachusetts General Hospital Institute for Heart, Vascular and Stroke Care present a dynamic symposium on systemic cardiovascular disease.
Novel Therapeutic Strategies for Systemic Cardiovascular Disease
An Integrated Approach to Treating Heart Failure and Valve Disease, Vascular Disease and Stroke
Friday, March 8, 2013
5 pm - 8 pm
InterContinental San Francisco
888 Howard Street
San Francisco, California 94103
Novel Therapeutic Strategies for Systemic Cardiovascular Disease: An Integrated Approach to Treating Heart Failure and Valve Disease, Vascular Disease and Stroke presents evidence-based strategies that will impact your practice performance and improve outcomes for your patients with cardiovascular disease. The expert faculty will provide insights and opinions on methods for providing comprehensive diagnosis, treatment and management of patients while working in an integrated, multispecialty program.
5:00 pm Registration/Dinner
5:15 pm – 5:25 pm Welcome/Agenda Overview
5:25 pm – 5:50 pm Heart Valve Decision Making: The impact of the percutaneous option
5:50 pm – 6:00 pm Q&A
6:00 pm – 6:25 pm Emerging Therapies for Thoracic Aortic Disease: The link between medicine, surgery and endovascular technologies
6:25 pm – 6:35 pm Q&A
6:35 pm – 7:00 pm Pulmonary Embolism Response Team: The new, multidisciplinary approach to treatment
7:00 pm – 7:10 pm Q&A
7:10 pm – 7:35 pm Atrial Fibrillation and Stroke: Rapid evolution of treatment opportunities
7:35 pm – 7:50 pm Q&A
7:50 pm -8:00 pm Closing Remarks
Learning Objectives
This educational activity is not part of ACC.13; however, the content was reviewed and approved by the ACC.13 Program Committee.
CME/CEU Credits: Approved for 2.75 AMA PRA Category 1 Credit(s).
U.S. News & World Report ranks Mass General the #1 hospital in America based on our quality of care, patient safety and reputation in 16 different specialties. Learn more about why we're #1
Search the archive for previously published news articles, press releases and publications.
Departments and Centers at Mass General have a reputation for excellence in patient care. View a list of all departments.


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Faultline Studios is pleased to announce that we've partnered with the Audio Alchemist and Bay Area Music Collective to present a series of integrated demos featuring BLUE Microphones, Manley Labs, Dangerous Music and Guzauski Swist to be held in conjunction with the 133rd Annual AES conference happening right down the road Oct. 27th through 29th.
Stop by the studio from 10am to 6pm Saturday, Sunday or Monday to check out the demo and our new booth for Studio D! There will be a shuttle from Moscone Convention Center to Faultline running during the demo hours.
Afterwards be sure to check out one of our favorite local eateries: the newly opened 1058 Hoagie or the venerable Deli Board on your way back to the show floor.
For attendees in town early and local friends we'll be having a low key happy hour Friday October 26th from 7pm to 10pm to celebrate the start of AES and toast another year of making sweet sweet music together.


text: Volunteer Volunteer members share their time and knowledge to advance the association. Through their work with AORN committees, state councils, specialty assemblies and national leadership, volunteers help shape AORN standards, practice recommendations and educational opportunities. Are you looking for a way to get involved and have a voice within AORN? Volunteer today! Committees Advocacy


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Master Classes (August 1 through October 31)
Friday, September 6
- 6:30 PM Aerial Dance Intensive
Saturday, September 7
- 12:00 PM Aerial Dance Intensive
Sunday, September 8
- 12:00 PM Aerial Dance Intensive
Monday, September 9
- 12:00 PM Aerial Dance Intensive
Event Topics
- Alumni
- Application Deadline
- Arts
- BU Central
- Careers
- Center for the Humanities
- Charity & Volunteering
- Commencement
- Conferences & Workshops
- Examinations
- Featured Events
- Food & Beverage
- Global
- Keyword Initiative
- Lectures
- LAW Community
- Meetings
- Orientation
- Other Events
- Religious Services & Activities
- Special Interest to Women
- Sports & Recreation
- Social Events
- Study Abroad
BU Today: Latest Headlines
- New BU Today Mobile App Available Now October 9, 2015Reading this on an iPhone? Consider going to the App Store icon and downloading the new free BU Today News & Events app. The app offers current and archived campus news, feature stories, and multimedia content from BU Today. It includes the University events calendar, social-media sharing of articles, and other features, among them comments […]
- What's Doing This Columbus Day Weekend October 9, 2015With the fall semester well under way, everyone's ready to take advantage of the three-day Columbus Day holiday weekend. It's a great opportunity to explore the city and enjoy fall foliage. We've compiled a list of things to do this weekend in and around Boston, many free and all reachable by T. Saturday, October 10 […]
- COM Alum to Screen Film about a Broadway Legend October 9, 2015When actress Elaine Stritch died in July 2014 at age 89, she left behind a string of theater, television, and film credits that any performer would envy. Best known for her role as Alec Baldwin's hilariously demanding and cantankerous mother on the TV comedy 30 Rock, Stritch was also a veteran stage actress who starred […]
- Dorms Compete in October Energy Challenge October 8, 2015"Turn off the lights when you leave the room." "Switch to energy-efficient light bulbs." "Take shorter showers." "Unplug your electronics when you're not using them." Rather than just environmental nagging, what if these exhortations were your ticket to a free ice cream social? Boston University Student Government and sustainability@BU are offering that prize to the best watt-whittling […]
- Alcohol Enforcement Patrol Stats 2015 October 8, 2015With the new semester, BU has resumed its campaign against alcohol abuse, bolstering police patrols of known party neighborhoods, citing students for public intoxication, dispersing loud parties—and crucially, publicizing statistics on booze-control efforts by University, Boston, and Brookline police. The graphic above shows last weekend's enforcement statistics. See statistics from prior weekends below. If you, […]


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Band photos from the East Lee County-Barron Collier high school football game Friday, Sept. 7 at Barron Collier High School. The Jags got their first victory of the 2012 season with a stunning 19-13 triumph over the Cougars. Submitted by naplesnews.com contributor Vicki Baker


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Tim Berry
Michael Ohlman
Henry Urrutia
Dariel Alvarez
Jonathan Schoop
Eduardo Rodriguez
Branden Kline
Jason Gurka
Schoop and Rodriguez are the best of the bunch.
Ohlman after a promising 2012 looks to have put it together offensively. Defensively he puts up respectable numbers.
Berry, Kline and Gurka all look like relievers.
Two older Cuban prospects. Scouts are generally negative on their potential ML impact.


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BILLY JAFFE SHOWN THE DOORMSG agrees to deal, Islanders block analyst's return
6:30 pm: Comments thread closed. Stay tuned for any Matt Moulson news. As of tonight, there was nothing to report on negotiations between the Islanders and the 30-goal scorer as they attempt to settle. Arbitration hearing is scheduled for 9:00 am Tuesday. I hope everyone enjoys a wonder summer weekend. Stay cool.
5:40 pm: The invaluable sports media critic Neil Best, of Cablevision-owned Newsday, backs up what Point Blank has written. Writes Best: "Three people familiar with the decision said the discontent with Jaffe came from the Islanders and not the network."
2:35 pm: As I posted about an hour ago on Twitter, multiple sources have told Point Blank that MSG Network had a multi-year contract in place with Billy Jaffe, but the Islanders declined to approve Jaffe's return because his analysis was not positive enough. To be blunt, I must have missed those games.
In the mix are Butch Goring, who could move up from his studio role, and Denis Potvin. if Butch gets the top job, Denis could get the studio role. No matter who gets it, do not expect even the slightest trace of constructive criticism.
11:30 am: MSG Network releases statement to Cablevision sister newspaper Newsday: "MSG wishes Billy luck in future endeavors. The network will name a new TV analyst in the near future." Figure on a former Islander, which will make most of this go away quickly.
9:05 am: Bob Raissman reports in today's print edition of the Daily News that color commentator Billy Jaffe will not have his contract renewed. Jaffe lasted four seasons and built a strong reputation around the NHL and with fans, adding work with VERSUS and appearing on the popular "NHL Live" on XM/Sirius that was simulcast on NHL Network.
The Islanders, by letter of their broadcast contract, give their blessing (or lack thereof) to all announcers. Although MSG Network hires and pays the broadcasters, the Islanders – like most teams – have the ultimate say. In recent seasons, the franchise has been notorious in insisting their broadcasts do not contain the slightest bit of criticism. (You won't see any in Cablevision-owned Newsday. Last season, there were two reasonably critical articles in one day. Hadn't happened before that day, won't ever again.)
Despite the Islanders finishing 30th and 26th in the league the last two seasons, I never saw anything but 100% positive analysis from Jaffe. In fact, no one more optimistically and studiously told the story of the slow and steady recall better than him. If there was a dispute between MSG and Jaffe, I would think the Islanders would push to keep one of their biggest public advocates. In addition, he was a regular volunteer for the Islanders at draft parties and on segments for Islanders TV.
Jaffe has a home, a wife and two very young children on Long Island. He repeatedly said he hoped to be in New York for a long time. I doubt this has to do with anything contractually. So what I'm saying is, this one completely baffles me. I have not spoken with him in a while and did not see it coming. Since I was part of hiring the man and I consider him a friend, I'll wait for a statement or coverage elsewhere.
Comments on Billy Jaffe's departure.


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Call Now:1-800-435-4074
This succulent seafood selection, brought to you by award-winning Chef Kent Rathbun, is just the sort of flavorful fare you've been looking for. Served in a rich and creamy Parmesan sauce with tender orzo pasta and spinach, this luscious lobster and shrimp dinner entrée offers you a perfectly decadent taste experience with none of the after-dinner guilt.
Lose 5 lbs. in your first week
plus 1 inch off your waist**


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God's Peace!
Welcome to the Apostolic Lutheran Church of America website! Here you can find a variety of resources to learn more about the ALCA and its member churches.
God bless you!
Latest News
- Listen to sermons from 2014 convention here.
- 2015 Convention - New York Mills School - June 25-28


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Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study will investigate the inflammatory response. People with abnormal regulation of inflammation and immune defects often have an exaggerated or depressed inflammatory response that results in poor healing of recurrent infections. This study will measure and compare amounts of inflammatory mediators (chemicals involved in the inflammatory response) in healthy normal volunteers and in patients with abnormal immune responses.
Healthy normal volunteers and patients with host defense defects or excessive inflammation, as in vasculitis syndromes, may be eligible for this study. Patients must be between 6 and 65 years of age.
Participants will have eight small blisters raised on the forearm using a gentle suction device. The top of the blisters will be removed with scissors and a plastic template will be placed over the blisters. The wells of the template will be filled with a salt solution or a mixture of the subject s serum (fluid part of the blood without cells) and a salt solution. Some blisters may be covered with coverslips a small round piece of very thin sterilized glass before adding the fluid. Blister fluid will be removed from the wells at 3, 5, 8, and 24 hours with a syringe and analyzed for inflammatory mediators. A scab will form over the blisters and fall off in about 2 weeks.
Participants will have about 4 tablespoons of blood drawn in order to compare the inflammatory mediators in the blood with those in the blister fluid.
Healthy Volunteers
Abnormal Phagocyte Function
|Study Type:
|Official Title:
|Comparison of Inflammatory Responses in Normal Volunteers and Patients With Abnormal Phagocyte Function Using the Suction Blister Technique
- To identify mediators that contribute to the inflammatory process and granuloma formation by comparing mediators collected from healthy volunteers to patients with abnormal regulation of inflammation and patients with host defense defects. [ Time Frame: Ongoing ] [ Designated as safety issue: No ]
|Estimated Enrollment:
|Study Start Date:
|April 1990
Patients with abnormal regulation of inflammation and with host defense defects often have an exaggerated or depressed inflammatory response with resultant difficulty in healing of recurrent infections. Delayed healing can be manifested by either a delay in wound healing, granuloma formation along the incision line, or dehiscence of a partially healed wound without evidence of infection. We are interested in studying the dynamics of host immune defenses during an experimentally induced inflammatory response using a well-studied suction blister device. This protocol is designed to study mediators of inflammation in patients with host defense defects as well as patients with excessive inflammation as in the vasculitis syndromes. We will measure mediators of inflammation (e.g., C5a, leukotriene B4, interleukins, chemokines, tumor necrosis factor, interferon-gamma) by ELISA, radioimmunoassay, High Performance Liquid Chromatography, multiplex cytokine assays, and/or bioactivity assays. Furthermore, molecular characterization and host defense functions (e.g., respiratory burst, chemotaxis, phagocytosis, microbicidal activity) of cells recruited to the blisters will also be examined. In addition to the analysis of cell function, RNA will be prepared and subject to DNA microarray or quantitative RT-PCR studies to measure expression and dynamics of key inflammatory mediators. Many of these factors contribute to the inflammatory process and several are thought to be important in granuloma formation. If patients are found to have abnormal amounts of these mediators when compared to healthy volunteers or patients with other abnormalities it will help us understand the basis for their disease and new therapeutic strategies. For example, this blister study allowed us to identify a patient subsequently shown to have IRAK4 deficiency.
|Ages Eligible for Study:
|6 Years to 65 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Patients having or thought to have an immune defect between the ages of 6 and 65 years (inclusive) are eligible to participate.
Be a healthy adult of either sex and between the ages of 18 and 65 years old.
Weight greater than 110 pounds.
Not have any heart, lung, or kidney disease, or bleeding disorders.
Not have a history of viral hepatitis (B or C) since age 11.
Not have a history of intravenous injection drug use.
Not have a history of engaging in high-risk activities for exposure to the AIDS virus.
Not be pregnant.
Patients less than 6 or greater than 65 years of age.
Less than 18 years old or older than 65 years.
Have viral hepatitis (B or C).
HIV positive.
Receiving chemotherapeutic agent(s), or have underlying malignancy.
Have history of heart, lung, kidney disease, or bleeding disorders.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001257
|Contact: Mary E Garofalo, R.N.
|(301) 827-9758
|Contact: Kol A Zarember, Ph.D.
|(301) 402-1802
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 email@example.com
|Principal Investigator:
|Kol A Zarember, Ph.D.
|National Institute of Allergy and Infectious Diseases (NIAID)
Additional Information:
|Responsible Party:
|National Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) )
|ClinicalTrials.gov Identifier:
|NCT00001257 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 3, 1999
|Last Updated:
|August 28, 2015
|Health Authority:
|United States: Federal Government
Keywords provided by National Institutes of Health Clinical Center (CC):
Normal Volunteer
Abnormal Phagocyte Function
ClinicalTrials.gov processed this record on October 09, 2015


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When you hear the word "preppy," a few things immediately come to mind: pearl necklaces, penny loafers, and characters like Blane and Steff from Pretty in Pink. In other words, it conjures up a look that hasn't been wildly popular since the '80s--until now. Thanks to the combination of Tommy Hilfiger's Prep World (a pop-up store touring the globe with a capsule collection of the designer's prep-inspired classics) and the popularity of two style books (True Prep: It's a Whole New Old World, which is the follow-up prep guide to Lisa Birnbach's The Official Preppy Handbook, and the first English translation of the seminal Take Ivy), the preppy look is finally returning to the spotlight. Even better, designers like Tory Burch are creating seriously cool options with nary a whale print in sight! In honor of this summer-friendly trend, we've sourced some of the best of-the-moment, ultra-affordable preppy pieces for your purchasing pleasure. Whether it's a pair of nautical-chic wedges or a polished plaid dress, these handpicked items will freshen up your mid-season wardrobe without breaking the bank, so feel free to shop today's Under $100 story sans stress. Whatever you buy, just know that Muffy would definitely approve...
Brixton Delta Straw Hat ($42) in Brown
While you might have spotted a preppy teenager sporting a visor at the country club back in the '80s, today's prepsters are likely to be wearing this charming straw hat by Brixton. This topper will effectively shield your face from harsh summer rays while keeping you chic in the heat. Go incognito and team it with a pair of oversized shades for a foolproof beach-day look!
J. Crew Stripebreaker Sweater ($78) in Champagne Honey
Nothing says "preppy" like a striped sweater in a bold, primary color, so we simply had to bring you a top-notch option. That said, we happen to think this Stripebreaker Sweater from J. Crew is the cream of the crop! Made out of lightweight, breathable cotton and boasting honey-colored stripes, this piece is definitely a must-buy. It will also last you well past summer--come fall, simply layer it under a jacket and you'll have a superb ensemble in no time!
Forever 21 Shorts ($15)
Though these Forever 21 shorts aren't plaid, covered with tiny crabs, or Nantucket reds, they are certainly a nod to the preppy look, thanks to the pleated front detail, cuffed hem, and airy linen fabric. The ideal balance between structured and relaxed, these shorts will work for any number of occasions this season!
River Island Green Padlock Bag ($40)
While roomy beach totes are a great option if you're headed to the coast, we think a small bag in a bright color is ideal if you plan on sightseeing in the city. This version by River Island fits the bill perfectly; its Kelly green color (a signature preppy hue) is irresistible, especially when paired with pale pink pieces. We also adore its padlock detail--a subtle nod to the stables--and compact size! We suggest picking up this purse ASAP and carrying it across-body for a fuss-free summer outing!
D.V. by Dolce Vita Nero Platform Wedge Sandals ($79) in Navy
Everyone knows that wedges are a summer wardrobe staple, a fact that's decidedly true when finishing off a preppy look. Accordingly, we selected this nautical-inspired pair by D.V. by Dolce Vita. The navy color and contrasting white stitching is quite cute and will work with tons of ensembles this season. Team them with anything from white cropped pants to denim cutoffs and you'll have a winning outfit in no time!
ASOS Check Dress with Bow Belt ($78)
If you ever had to wear a uniform in high school, you've probably renounced the plaid skirt altogether; however, we simply adore ASOS' Check Dress for a serious upgrade on the schoolgirl look! Featuring a tough-girl leather bow at the waist and a desirable mid-thigh hemline, this dress is our latest obsession from the beloved online retailer. We suggest wearing this charming frock with flats now or tights and boots in the fall.
Casio Analog Leather Strap Watch ($40) in Cognac Snake/Gold
Think you have to spend a fortune on a sophisticated watch? Au contraire! All you need is this Casio, as it has a classic gold face, luxurious leather strap, and a decidedly affordable price tag. Trust us, you won't want to take it off, as it will go with literally any outfit and is waterproof to boot!
Coincidence & Chance Scalloped Chiffon Blouse($59) in White
Collared shirts are always a classic choice, but we love a feminine twist on this wardrobe staple, hence, our inclusion of this blouse by Coincidence & Chance! We're smitten with its Peter Pan collar and scalloped details, which give the shirt a whimsical vibe we can't resist! Pair it with a red pencil skirt for an on-trend, color-block look for the office, or team it with denim shorts for a fantastic weekend ensemble. However you style it, we promise you'll fall in love with this versatile blouse!
Tommy Hilfiger Web Belt ($48) in Red
During the warm-weather months, we tend to have a penchant for easygoing, loose-fitting tops and dresses, which is why a great waist-defining belt is a total savior. This one by Tommy Hilfiger will ensure that your figure isn't lost in a sea of breezy cotton and its classic red cloth and leather combo would look smart with all your neutral pieces! All in all, we think this is one accessory that's too good to pass up, so you better get one before it's too late.--Erin Fitzpatrick


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Video: Proposed Hotel in Snyder Gets Go Ahead
AMHERST, NY - A controversial hotel planned for Snyder is now a go after getting final approval from the town planning board and local industrial development agency.
That's despite strong criticism from people who live in that area.
Iskalo Development plans to build a Hyatt Place Hotel right behind the current Lord Amherst Hotel on Main Street.
Neighbors have fought the project for months, saying it will ruin the view from their homes, hurt their property values, and invade their privacy.
The planning board approved the project by a vote of 5-2 last night.
The Amherst IDA voted 4-3 Friday to give the project a tax break package worth more than $1 million.