text:
Pharmacokinetics Study of Gamma-aminobutyric Acid (GABA-PK)
Recruitment status was Recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to determine upon administering GABA orally to a person how it is absorbed, distributed, as well as the drug's pharmacological effects on the body such as glucose levels, serum C-peptide and/or insulin levels (referred to as pharmacokinetics/pharmacodynamics). We will conduct experiments in normal subjects to address these questions.
Diabetes Mellitus
Diabetes Mellitus, Type 1
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Autoimmune Diseases
Immune System Diseases
Phase 1
|Study Type:
|Study Design:
|Time Perspective: Prospective
|Official Title:
|The Pharmacokinetics of Gamma-aminobutyric Acid in Healthy Volunteers.
- pharmacokinetic characteristics of γ-aminobutyric acid (GABA) [ Time Frame: baseline and up to 30 days ] [ Designated as safety issue: No ]
The primary endpoint of this study is to obtain the pharmacokinetic characteristics of γ-aminobutyric acid (GABA), including:
- Area under the plasma concentration-time curve from time 0 to the last quantifiable concentration (AUC0-t),
- Area under the plasma concentration-time curve from time 0 extrapolated to infinity (AUC0-∞),
- Maximum observed plasma concentration (Cmax),
- Time to maximum plasma concentration (Tmax), and
- Terminal elimination half-life in plasma (t½)
- serological characteristics [ Time Frame: baseline and up to 30 days ] [ Designated as safety issue: No ]plasma glucose levels, insulin, C-peptide and glucagon levels will be measured
- Exploratory measures [ Time Frame: baseline and up to 30 days ] [ Designated as safety issue: No ]plasma glucagon-like peptide-1 (GLP-1) and glycated serum protein (GSP)will be measured.
Biospecimen Retention: Samples Without DNA
This is an open-labeled, 3-phase, self-control study. In phase 1, blood is sampled from volunteers who will take placebo to obtain the baseline value. In phase 2, volunteers will take a single oral dose of 2000 mg GABA. There are at least 7 days between the two phases. In phase 3, volunteers will take a repeated oral dose of 2000 mg GABA (thrice daily for seven days). There are at least 5-7 days between phase 3 and phase 3. In each phase, individuals will be observed for 24 hours to obtain the complete concentration time curve. 4 ml of blood will be sampled at the following time-point for predose and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, 12 and 24 hour postdose.
|Estimated Enrollment:
|Study Start Date:
|July 2013
|Estimated Study Completion Date:
|July 2014
|Estimated Primary Completion Date:
|February 2014 (Final data collection date for primary outcome measure)
Type 1 diabetes is an autoimmune disease resulting from the progressive loss of pancreatic insulin-secreting beta-cells. This consequently leads to a lack of insulin and elevation of blood sugar, namely hyperglycemia, which is a major cause for the development of diabetes and its acute or chronic complications. The current treatment for type 1 diabetes requires a life-long dependency on daily insulin injections, causing inconvenience and burden to patients. Drug-induced hypoglycemia is also common as it presents a major challenge in insulin therapy. Furthermore, although insulin therapy is lifesaving, it is not a cure as it neither reverses the progression of the disease nor prevents the development of serious complications associated with this disease. New treatments are urgently needed.
Recent studies have demonstrated that a natural chemical found in the brain, gamma-aminobutyric acid (GABA), which is also produced in large quantities by pancreatic beta-cells, has beta-cell regenerative and immunoregulatory effects. Importantly, GABA prevented and partially reversed diabetes in type 1 diabetes mouse models. It is important to address essential questions regarding the potential effects of GABA in diabetic patients in humans. Given the largely unknown mechanism of action of GABA in the pancreas, and the limited information on how GABA is absorbed, distributed and eliminated from the human body, we plan to examine these issues (referred to as pharmacokinetics/pharmacodynamics) in normal subjects.
The outcome of this study will provide useful information on the mechanism of action of GABA in human subjects.
|Ages Eligible for Study:
|19 Years to 40 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Residents of Shanghai
Inclusion Criteria:
- Volunteers in good health condition between 19 and 40 years of age (inclusive) at the time of signing the informed consent.
- Body mass index (BMI) between 18.5 and 24 kg/m2 (inclusive), with weight greater than 50 kg.
- Not on any medication 2 weeks before screening.
- No blood donation within 3 months before screening.
- Must sign the informed consent. Note: Blood and biochemical tests must be normal during the screening. However, if the participant's test-results were beyond the normal range, the individual can still be recruited as long as the results do not affect the experiment.
Exclusion Criteria:
- Abnormalities of physical examination, laboratory tests, or ECG in screening, which may influence the results of the study.
- Previous or existing history of severe heart, liver, kidney, gastrointestinal, nervous system, mental, or metabolic abnormalities as well as other diseases which can affect drug absorption, circulation, metabolism, or excretion.
- History of alcoholism, smoking, or drug abuse within the past 1 year.
- Participation in any clinical drug study within the past 30 days.
- Any definite or suspected allergy or family history of allergy to GABA or any other similar drugs.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01917760
|China, Shanghai
|Department of Endocrinology and Metabolism,Huashan hospital
|Shanghai, Shanghai, China, 200040
|Contact: Zhaoyun Zhang, MD, PhD 021- 5288-8286 firstname.lastname@example.com
|Contact: Yi Wang, MD, PhD 021- 5288-7022 firstname.lastname@example.com
|Principal Investigator: Yiming Li
|Principal Investigator: Qinghua Wang
|Principal Investigator: Zhen Jiao
|Principal Investigator:
|Yiming Li
|Huashan Hospital
|Principal Investigator:
|Qinghua Wang
|Huashan Hospital/St Michael's Hospital
|Principal Investigator:
|Zheng Jiao
|Huashan Hospital
No publications provided
|Responsible Party:
|Zhaoyun Zhang, professor of endocrinology and metabolism, Huashan Hospital
|ClinicalTrials.gov Identifier:
|NCT01917760 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 6, 2013
|Last Updated:
|August 5, 2013
|Health Authority:
|China: Food and Drug Administration
Keywords provided by Huashan Hospital:
Gamma-aminobutyric acid
Additional relevant MeSH terms:
Autoimmune Diseases
Diabetes Mellitus
Diabetes Mellitus, Type 1
Endocrine System Diseases
Glucose Metabolism Disorders
Immune System Diseases
Metabolic Diseases
Gamma-Aminobutyric Acid
GABA Agents
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Pharmacologic Actions
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on October 13, 2015


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BUFFALO, N.Y. - While a formal announcement on the hiring of Doug Marrone to be the Buffalo Bills next head coach is expected to be made Monday, many Western New Yorkers are eager to find out more about the next head of the team.
The Bills have yet to officially confirm the hire.
A source tells 2 on Your Side's Adam Benigni Sunday afternoon that the Bills are in the final stages of working out the details of Marrone's contract.
Click the player above to watch our Adam Benigni, Stu Boyar and Jonah Javad in a roundtable discussion on Marrone and his coaching ability.

subset: commoncrawl


text:
York Rangers vs Washington Capitals
7:30 p.m., Monday
Verizon Center
Rangers Record: 28-19-3
Capitals Record:
Tonight, Jan. 24, the Rangers
face off against the Capitals in Washington. The Rangers, 6-4 in their last 10, are coming off a
dramatic shootout victory over the Atlanta Thrashers on Saturday night. The
Caps also had an exciting last game, enjoying an Alex Ovechkin hat trick
against the Canadiens. Washington is currently in fifth place in the Eastern Conference,
but they do not sit comfortably there, as they are only three points ahead of
both the Canadiens and the Rangers. A win for the Rangers tonight would allow
them to gain valuable ground in what is becoming a close playoff race.
The Rangers played an emotional
game against Atlanta which featured two comebacks-- one with less than six
minutes remaining in the game--and a shootout. Once again for the Rangers, the
game featured heroics from unexpected places, with goals from Brian Boyle,
newcomer Wojtek Wolski and the shootout winner from Mats Zuccarello. Rookie
Derek Stepan continued his impressive streak, adding an assist on Wolski's goal
to give him five points in his last five games. If the Rangers continue to play
in this fashion, the growing list of injured players should not prove to be an
insurmountable hurdle.
The Rangers added more players
to the injury list in the last game, losing forward Brandon Prust and
defenseman Dan Girardi in the game against the Thrashers. These new issues add
to New York's laundry list of injuries: forwards Derek Boogaard,
Ryan Callahan, Erik Christensen, Brandon Dubinsky, Ruslan Fedotenko, Alex
Frolov and Vinny Prospal. Girardi is the first defenseman to face the New York plague this season, and Michael Del Zotto was called up
from the Connecticut Whale to replace him. The Rangers also called up forward
Evgeny Grachev to help fill the vacated roster spots.
The Caps suffer from injuries to top forwards Eric Fehr and
Alexander Semin. Ovechkin's recent hot streak, however, has made the injuries
seem less crippling than they could be.
In the last match-up between the Rangers and Capitals, the
Rangers blew out last year's President's Trophy winners with a 7-0 victory. Can
they repeat their success, even without many of their top forwards? Make sure
to tune in at 7:30 to find out!


text:
As Brevard School Board members consider closing four schools and cutting $30 million, parents are lobbying officials to dip into the district's savings accounts to help pay for a special election in November to raise school taxes and stave off cuts.
A rally and march to school district offices is planned for Thursday evening. Scheduled two hours before a public forum starts at 6:30 p.m., parents hope the demonstration will help make their views heard.
"We want to show the community is coming together," parent Christine McClure told Local 6 News partner Florida Today. "We really want to show support for all our schools and our students, and that's really the focus of the march."
Elected officials are not expected to attend, however. Not wanting to "change the focus" of the forum — which will discuss the details of proposed boundary changes if schools are closed — Board Chair Barbara Murray said they were advised to skip it.
"This meeting is not to discuss school closures," she said. "The meeting is to educate parents and to make them aware of the boundary changes related to the potential school closures."
District staff will use input from the forum in developing their final recommendations to close Gardendale, Sea Park and South Lake elementary schools and Clearlake Middle School. If the school board decides on Jan. 22 to close the schools, the vote will simultaneously enact new boundary lines for next school year.
McClure expressed disappointment that officials will not be present — but also a resolve to continue building support.
A parent group that she's a part of, Save Brevard Public Schools, wants to send a new tax proposal to the voters in November: A quarter-cent sales tax and an extension of a quarter mill property tax set to expire in June. That would raise an estimated $24 million a year, less than the $30 million in proposed cuts.
So far, around 1,000 people have signed an online petition asking school board members to dip into a $19.9 million contingency fund to pay for a special election, an estimated $800,000 cost.
The fund is similar to an emergency savings. Since officials first started stashing money away in 1997, it's only been dipped into twice — following the storms in 2004 — to help with cash-flow issues until insurance and FEMA money came in.
"One bad storm could wipe out the contingency," said Judy Preston, Brevard's associate superintendent of finance.
The amount in reserve is dictated by school board policy, which requires it stay above 3 percent of general revenue. It's currently close to 4.2 percent — a percentage that has grown in recent years. While the dollar amounts have stayed the same during the last four years, the district's revenue has decreased.
"To me, it qualifies as the time to use those contingency funds," parent Michelle Speisman said. "We're not recommending they dip below the 3 percent, but we are recommending that they could use some of those funds and not affect their credit rating."
Group members also believe there's enough money to bridge a funding gap — until a special election can be held — by using a $50 million capital fund balance, which is similar to a savings account for facility needs.
Preston said that the fund is already being spent down, however, and is expected to end this school year with a balance of $34 million.
"You can only go about two more years of spending like that, and the money will be gone," she said. "We're already deferring an awful lot of capital projects. We've drawn the line in the sand."
With much public discussion about a special election, the school board may take a position on it at the Jan. 22 school board meeting, according to School Board Member Amy Kneessy.
She opposes such an effort, and would rather see a tax measure put on the 2014 general election ballot — at no extra cost to the district.
"I don't see where we have $800,000 to put this on a special ballot for this fall. ... This is an issue for the 2014 ballot," Kneessy said, adding: "If they want to raise the money to go forward with this, that's a different question."
School district leaders have cautioned board members against a special election. How would they justify it— and its expense — if the vote failed?
"About 139,000 people in this community said no" to the half-cent sales tax, spokeswoman Michelle Irwin said. "So we have to be very careful. They must have been informed enough to know they wanted to vote against it."


text:
Just pulling your chain!
I got that Dave :-)Just saying whats happening down the coal mines.
Edited by stephenm on 03/20/2013 20:29:56 MDT.
if you're not going to load it too heavy, the Pinnacle at ~ 70-75 liters does a good job of eating up bulky winter gear, I added a light frame to mine in case I end up carrying snowhoes or the like- carrying snowshoes and a shovel I'm still under 30 #'s for a 3 day outingas one of the posters mentioned, shelter weight (and volume!) can vary pretty wildly in the winter from a pyramid @ 2#'s to 9#+ for a heavy duty Hillberg or the like, that will most certainly influence your pack choiceyou probably guessed, but I'm using a 2# pyramid :)that's my wife's diminutive pack in the background, have to keep hers extra light!!!!
That looks nice Mike, I have an Rei Flash 62 for weights under 30lbs or so, this one is going to be a big ass load hauler.Al.I am thinking I will bite the bullet and give Dan MChale a call, I know his packs are expensive but if I don't have to buy another winter pack for 10 years then I am up money.
Check out Section Hiker. His March 14 2013 post had his winter backpacking gear list for the White Mountains, where he's been peak bagging. He lists something called a Cold Cold World Chaos Backpack, with a listed weight of 58 ounces. He quotes a total weight of 44 pounds of gear, food, fuel and water for a 4 day trip, and a total skin out weight of 52.7 pounds.
Here's sectionhiker's review of the Chaos Diane mentions above:http://sectionhiker.com/cold-cold-world-chaos-backpack/And a more recent recap of winter pack recommendations:http://sectionhiker.com/the-best-backpacks-for-winter-hiking-and-backpacking/
Edited by FamilyGuy on 07/08/2013 23:20:13 MDT.
Just had a very pleasant pone call with Dan, the cheque is going in the post this week :-)
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text:
Short Sleeve Dexter Plaid Shirt (Men's)
Out of Stock Product Number: 32463
Pull the double duty from crag to street in the Dexter Plaid. Quick-drying and moisture-wicking with added UV protection, the lightweight Supplex fabric is abrasion resistant and durable, yet soft and cottony to the touch. Perfect for now, or pack it for later.
- Packable, Breathable, Lightweight Performance Woven Fabric
- Ultraviolet Protection Factor (UPF) 35
- Abrasion Resistant Nylon Supplex
- Quick-Drying and Wicking
- Durable Flat Felled Seams with Contrast Interior Stitch
- Shirt Tail Hem, Bias Single Patch Pocket and Novelty Pieced Back Yoke
Gender: Men's
Weight: 4.9oz (138.9g)
Material: 100% Nylon Supplex 2.5 oz/yd
Fit: Semi-Fitted
Season: S13 S14
Vendor ProductId: 62970
Review ProductId: 32463


text:
Palisades > Starlight Peak > Climber's Log
Starlight Peak Climber's Log
[ Sign the Climber's Log ]
|Rick Kent
|Route Climbed: NW Chute Date Climbed: Aug 21, 2005
|Climbed with Paul Allegretti (completebum), Courtney Pursell (cp0915), and Brian McElwain. Weather was beautiful! We climbed up half the mountain under the light of the full moon. We were surprised to see 2 headlamps descending off the mountain at 3:00am. Turns out they had the same strategy we did -- to wait for the moon to rise. Paul was first to summit and was already on top of the milk bottle by the time I got there. He climbed it 3 times: twice solo and once top-roped. We spent about an hour and half on the summit playing around and enjoying the day.
|Posted Aug 24, 2005 6:52 pm
|Route Climbed: NW Chute Date Climbed: August 21, 2005
|Climbed with Courtney and Rick. Easily one of the most enjoyable routes I've done in the Sierras. Once in the chute there is very little slogging and the climbing is enjoyable. The milk bottle lived up to its reputation making for some great summit shots.
|Posted Aug 22, 2005 2:45 pm
|Route Climbed: NW chute Date Climbed: Aug 21, 2005
|A fantastic route. Considerably faster and easier, and enjoyable, than I'd expected. Four hours from camp at T-bolt pass to the summit at a reasonable pace.
In researching the route, I learned that many (most?) parties rope up for the three class 4 sections on the way up to the Milk Bottle, but my partners and I did not find that necessary. The class 4 was solid, fun, and easy.
The Milk Bottle was spectacular and good fun.
|Posted Aug 22, 2005 1:39 pm
|Brian Kalet
|Route Climbed: Northwest Chute Date Climbed: July 31, 2005
|Got slightly off route near the top of the Northwest Chute and encountered a climber's gear from 1990...I know this because of his journal.
|Posted Aug 1, 2005 3:17 pm
|Route Climbed: Piper at the Gates of Dawn Date Climbed: July 26 2005
|An alright climb, a lot of loose rock to knock down on your partner. We summited but had a very long day.
17 hours to be exact.
|Posted Aug 1, 2005 2:42 pm
|Route Climbed: from Thunderbolt Date Climbed: 08/04
|I don't know what the deal was but we did 4 rappells or so to get to the top of the Underhill coulior. Besides that it was climbing that will be remembered - especially the unique summit block.
|Posted Apr 22, 2005 11:56 pm
|Steve Larson
|Route Climbed: Starlight Buttress Date Climbed: July, 1982
|Did this with Sara Steck on a day off from our duties with the Palisade School of Mountaineering. Back in the day. Lovely weather. No 'schrund problems, traversed over to North Pal, then down the U-Notch.
|Posted Nov 15, 2004 2:24 am
|Route Climbed: traverse from thunderbolt Date Climbed: sept 2004
|part of a long day!
|Posted Oct 24, 2004 5:00 pm
|Route Climbed: Traverse from Thunderbolt Date Climbed: August 9, 2004
|Awesome knife edge! We did not find the downclimb into the notch between T-bolt and Starlight and ended up rappeling on the East side (chimney) of the ridge. On our 2nd rappel, our rope got stuck and Bryan had to climb up to retrieve it. 3rd rappel ended up being almost parallel to the ground. Stayed on the very edge of ridge after the notch, great 5th class climbing!
Aside from rappeling, we did not rope up.
Click for the trip report.
|Posted Aug 16, 2004 11:28 am
|Scott M.
|Route Climbed: Traverse from Mt. Sill Date Climbed: August 12, 2004
|My partner and I made it to the base of the Milk Bottle with the weather conditions deteriorating. He said my eyes were wide open with fear when he shot my picture from the top of the Milk Bottle. Probably because lightning struck to the west just as I topped out. We made a hasty retreat as it began to snow lightly. Descended Underhill Couloir and back to the car skipping the planned leg over to Thunderbolt. The top was definitely a place I would have liked to linger if conditions were better. Witnessed some serious rock fall from the left side of Underhill just as we reached the glacier. Never knew I could run so fast with a pack on, wearing approach shoes, across a glacier. All this will make this peak a memorable experience for me.
|Posted Aug 13, 2004 5:24 pm
|Route Climbed: Traverse from Thunderbolt Date Climbed: August 17, 2002
|Traversed from Thunderbolt with ScottyS, and we continued on to North Pal, Polemonium, and Sill. This is a fun traverse with lots of cool climbing, at a moderate grade.
|Posted Oct 17, 2002 7:45 pm
|Craig Peer
|Route Climbed: Starlight Buttress Date Climbed: 2001
|Tim Winiarski, Bob Lathuras and I climbed this awesome route on a perfect day. Difficult ice over the 'shrund. We left the ice gear on a ledge and picked it up on the way down. Video taped the whole climb with 2 digital camcorders. Recommended.
|Posted Sep 23, 2002 1:30 pm
|Route Climbed: Traverse from T-bolt Date Climbed: August 23, 2002
|Traversed from T bolt and had some fun along the way. Headed toward N. Pal from here.
|Posted Aug 25, 2002 9:37 pm
|Bob Burd
|Route Climbed: From Thunderbolt Date Climbed: Aug 21, 2002
|Day 5 of the 2002 Mountaineers Challenge. From South Lake, climbed Southwest Chute #1 to Thunderbolt, traversed to Starlight - North Pal - Polemonium, down the Southwest Chute from the U-Notch, then back to South Lake. 14hrs CTC.
Climbed the milk bottle too, by the easier 5.4 route. Trip Report.
|Posted Aug 22, 2002 7:37 pm
|Route Climbed: Traverse from Thunderbolt Date Climbed: August 17, 2002
|Traversed from Thunderbolt to Starlight to N.Pal to Polemonium to Sill with bearbnz. We freeclimbed most of the route, with three rappels and three belayed (probably unneccesary) pitches total. Heavy packs and little route knowledge (Secor's book only) made for slow time --- OK, maybe lack of fitness contributed! Left the car around 530, summited Thunderbolt around 1100, summited Sill at 2130. Waited for daylight to decend an east couloir of Sill and walk down to the S. Fork Trail. Got to the car at 1330 on Aug. 18 and drove home to get some sleep.
|Posted Aug 18, 2002 9:25 pm
|Route Climbed: Palisade Traverse Date Climbed: July 6,02
|Started with my partner Ian, from T-bolt and traverse to Starlight then N. Pal, Pol, and Sill. Making for nice long rush. Oh, we never touched a rope.
|Posted Jul 9, 2002 2:04 am
|Route Climbed: North to South traverse. Date Climbed: 09/09/01
|Started from Sam Mack Meadow at 7:35 am, ascended the East Face of T-Bolt, then traverse South to Starlight Peak , North Pal, Pole, and continue traversing to Mt. Sill. Solo.
Back in time to bath while the sun was still up.
|Posted Nov 11, 2001 2:53 pm
|Route Climbed: Traverse from Thunderbolt Peak Date Climbed: August 1, 2001
|This was the second peak of my CA 14er tour.
I climbed over from Thunderbolt on the Class 4 ridge crest and then up to the top of Starlight's impressive 5.4 summit pinnacle. This was great fun! After Starlight, I soloed over to North Palisade, Polemonium, Sill, and finally over to Middle Palisade and down the South Fork of the Big Pine.
|Posted Aug 22, 2001 5:26 pm
|Route Climbed: Traverse from Mt. Sill Date Climbed: 08/05/00
|I started from Lake Elinore, in the South Fork region. I ascended Mt. Sill, traverse to Polemonium Peak, North Pal, and then to Starlight Peak. I descended the same way back to Lake Elinore. I free climbed with regular hiking boots. The most trouble was route finding, especially down climbing class 4/5 in my boots. If you like exposure, this is good climb. But scetchy if you are solo.
|Posted Aug 22, 2001 5:13 pm


text:
Tag Archives: Photography
As far back as Gavin Smith can remember, he used to sneak in his dad's closet to borrow his professional camera. Putting his own film inside, he'd shoot a series of pictures and then carefully replace his dad's roll of film. Eventually, he learned to use the camera better than his dad. In high school, […]
Posted in Manitou News, Miscellaneous
Also tagged Gavin Smith, Gavin Smith Photography, hobby, partnerships, photoshoot, Pontoon (boat), pontoon boats


text:
16 U.S. Code § 1826b - Duration of denial of port privileges and sanctions
Any denial of port privileges or sanction under section 1826a of this title with respect to a nation shall remain in effect until such time as the Secretary of Commerce certifies to the President and the Congress that such nation has terminated large-scale driftnet fishing or illegal, unreported, or unregulated fishing by its nationals and vessels beyond the exclusive economic zone of any nation.
Source(Pub. L. 102–582, title I, § 102,Nov. 2, 1992, 106 Stat. 4903; Pub. L. 109–479, title IV, § 403(b)(2),Jan. 12, 2007, 120 Stat. 3632.)
Section was enacted as part of the High Seas Driftnet Fisheries Enforcement Act, and not as part of the Magnuson-Stevens Fishery Conservation and Management Act which comprises this chapter.
2007—Pub. L. 109–479inserted "or illegal, unreported, or unregulated fishing" after "driftnet fishing".
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


text:
Our health and fitness expert Doctor Derek Alessi joined us live at our Daybreak studios Sunday morning to talk about whole grain foods and maintaining a healthy diet.
Click the player above to watch Dr. Derek answer your health and fitness questions on Daybreak Sunday.
If you would like to e-mail a video question for Dr. Derek to answer on Daybreak Sunday, you can visit his website here.


text:
Speedo Men s Surfwalker Pro Water Shoes
Hot sand can make your trip to the shore miserable; do not let the hot sand ruin your time at the beach, use the Speedo Mens Surfwalker Pro Water Shoes. These updated styling to the classic all-purpose water shoes with quick drying jersey and mesh upper are what will make that trip to the shore a lot more fun. They feature soft EVA insole, and durable TRP outsole that offers maximum traction and long life. So just slip on a pair and let s go to the beach. Flip Flops throw sand up the back of your legs when you walk and cause wet legs to be covered in sand; if you want to get rid of it, then it is time to change your regular flip flops and get these Speedo Men s Surfwalker Pro Water Shoes.
This product has a limited warranty of 3 months.
(888) 477-3336


text:
Omaha Bank Hoard
David Hall: Though a relatively low mintage issue, the 1954-S is one of the most common silver Washingtons in Gem MS65 or better condition. Many original rolls were saved and many very nice coins exist today, including some incredibly toned ultra Gems.
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text:
Welcome to Smogon! Check out the Smogon Info Hub for everything you need to know about starting out in the community. Don't forget to introduce yourself in the Introduction Thread, too!
Welcome to Smogon Forums! Please take a minute to read the rules.
Smog Awards 2012 Discussion Thread
Discussion in 'The Smog' started by bojangles, Dec 28, 2012.
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- Not open for further replies.
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text:
Video: Man Charged in Death of 5-Year-Old Child
BUFFALO, NY-- Matthew Kuzdzal, 26, was arraigned Thursday morning on a second-degree murder charge in the death of 5-year old Eain Brooks, the Buffalo City Court has confirmed.
Buffalo Police say there was a rescue call to a home on Albany Street Sunday evening. Eain Brooks was taken to Women and Children's Hospital where he died on Tuesday.
An autopsy performed on Wednesday determined that Eain died as a result of blunt force trauma to the head.
The suspect's Facebook page seems to indicate that Child Protective Services (CPS) has been called to the home where Kuzdzal lived with five-year-old Eain.
He wrote: "I.find it funny people are saying i called cps on them and are saying if i did its wrong of me...(which i didnt) i mean y would i call when im dealing with them myself... [sic]."
Buffalo Police are not sure if Kuzdzal's record includes child abuse charges.
We called CPS and asked whether anyone had ever called worried about Eain's well-being. We were told by Deputy Commissioner Judith Shanley that we were not allowed to access any information about this case using the Freedom of Information Act.
But, Shanley did confirm that in addition to the criminal investigation being done by Buffalo Police, CPS is also investigating Eain's death.
Shanley tells us that when CPS investigates a child's death, the department has sixty days to figure out what happened. This includes talking with police, doctors and medical examiners and going over the medical report.
Again, Shanley would not tell us anything about Eain's case or whether her department had investigated allegations of abuse before his death.
Thursday, police did say they were not aware of being called out to the Albany Street house in the past.
We also reached out to some of Eain's relatives Thursday night, and didn't hear back. Funeral services for Eain will be held this Saturday.
Kuzdzal was not granted bail. His next court date is September 24.


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Washington Wizards v Los Angeles Clippers
DeAndre Jordan of the Los Angeles Clippers dunks against Emeka Okafor... News PhotoBasketball - Sport,California,City Of Los Angeles,DeAndre Jordan,Emeka Okafor,Full Length,Horizontal,Los Angeles Clippers,NBA Pro Basketball,Slam Dunk,Sport,Staples Center,Taking a Shot - Sport,USA,Washington WizardsPhotographer Noah GrahamCollection: National Basketball Association 2013 NBAELOS ANGELES, CA - JANUARY 19: DeAndre Jordan #6 of the Los Angeles Clippers dunks against Emeka Okafor #50 of the Washington Wizards at Staples Center on January 19, 2013 in Los Angeles, California. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and/or using this photograph, user is consenting to the terms and conditions of the Getty Images License Agreement. Mandatory Copyright Notice: Copyright 2013 NBAE (Photo by Noah Graham/NBAE via Getty Images)


text:
Carry this color and show your support for breast cancer research. Learn more about the Vera Bradley Foundation for Breast Cancer.
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By PAUL L. YOUNGSt. George
Recently the news broadcasts and the two daily newspapers that cover Utah have drawn attention to a controversial subject, that of Mexican immigrants (legal or illegal) wanting to get a Utah Drivers license. I fail to understand where is the problem with taking care of this problem.
We know that the government of Mexico issues to all its residents that are seeking employment an identification card with that persons picture on the card.
The State of Utah should legislate a law requiring that persons being of legal driving age from a foreign country must produce a drivers license from that country, which also contains that person's picture. This would let those in the drivers license division know that this person does understand how to drive an automobile.
As for those from Mexico they would have to produce their ID card and their Mexican drivers license. Once these two requirements were met, then the applicant can apply for Utah Drivers license, take the written test and if the written test is passed then the applicant would take the drivers test. If all requirements were met and passed then that person should be given a license with one stipulation: his drivers license from Mexico and his Utah drivers license must be affixed to his identification card.
These three certificates would then show the same picture of the applicant. That would eliminate the problem of borrowing or the lending of a drivers license to a person that cannot qualify.
This would prove beneficial to those companies or institutions that require a positive identification.


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Platinum Canadian Commemorative Coins
Platinum Canadian Commemorative Coins - In addition to the popular maple leaf coin, the Royal Canadian Mint produces Platinum coins in a variety of topics. Many of these celebrate the animals and other wildlife found across Canada. Others feature famous ships of Canada's past. Whatever topic or theme you may be looking for, you will likely find it here in beautiful Platinum!
To view available platinum coins or to get platinum prices, click on the image representing the platinum coins of your interest:


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Narrow your search
Need help with Apple Music and the other new features introduced in iOS 8.4? Apple has you covered with a new series of user guides.
The company is also broadening the reach of its iTunes U Course Manager, which helps teachers design and distribute their own customized courses.
You likely won't use iBooks on your Mac for much pleasure reading, but for research projects or other school work it can be a useful tool.
Screenshots appear in the iTunes Store showing the two new devices with the addition of a Touch ID fingerprint scanner.
iBooks is the go-to reading app to download on iOS devices, and Apple has done a good job making the interface intuitive and continually adding useful features.
Commentary: The design of Apple's long-anticipated smartwatch is sharp, but the company has been known to switch gears after a product launches.
Small publisher claimed it had acquired the trademark before Apple began using it to describe its e-reader platform.
A little more than a year after introducing its iBooks Author software, Apple has posted a section with some of the popular results.
Apple's reading app sports a clean interface, solid controls, and a well-stocked iBookstore for all your reading needs.
iBooks 3.0 was unveiled during Apple's iPad Mini event. One new feature in the app is the ability to scroll through a book, instead of turning pages. Here's how to enable it.


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Link: A Surprise Team?
It's a little late in linking to this, but a few of you had sent on a link to Hashmarks last week where they had five teams that were set to surprise in the coming season. Obviously, the Jets made the list:
They went from 10-6 and the playoffs in Eric Mangini's first year as coach to 4-12 last season. Chad Pennington caught much of the blame, but the Jets realized the problems went way beyond the quarterback. That's why the Jets were one of the league's most aggressive teams in the offseason.
At the start of free agency, they spent a fortune to get offensive lineman Alan Faneca, defensive tackle Kris Jenkins and linebacker/defensive end Calvin Pace and they used their first-round draft pick on Vernon Gholston, who can play defensive end or linebacker. Jenkins, who once was the best defensive tackle in the league, is in shape, focused and happy after clashing with Fox in Carolina the past few years.
Pennington and Kellen Clemens will compete for the starting job in training camp, but either quarterback should be fine behind a rebuilt offensive line. New England still owns the AFC East, but the Jets should be better than Buffalo and Miami and in contention for the playoffs.
I do think that Jenkins play will set the tone for how improved this defense is, and is one that will have cascading benefits … it directly affects the the DEs and ILBs, and if the DEs have better seasons, so will the OLBs. As far as the QB, it's something that a lot of national writers have used ink on in discrediting how ready this team is to contend for a playoff berth in 2008, but I'm in agreement with the sentiment that the reworked line will allow either QB to play substantially better at this point, and whoever wins the job will benefit from it.


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Harry Potter
Warner Brothers Pictures
News about Harry Potter, including commentary and archival articles published in The New York Times.
Selected Articles About Harry Potter
Studio Tour Casts Spells Just Like Harry
A mostly self-guided tour is now available at two vast Warner Bros. sound studios on the Leavesden Studios lot, about 20 miles northwest of London, where the Harry Potter movies were filmed.April 1, 2012 travelNews
The Fans Own the Magic
Others may control the copyrights, the royalties and the theme park receipts, but they can't keep Harry Potter's wizardry out of millions of hearts.July 3, 2011 moviesNews
The Sorcerers of Stagecraft
A decade's worth of Harry Potter movies required lots of off-screen wizards. Now the gig of a lifetime has reached its happy ending.July 10, 2011 magazineNews
Movie Review | 'Harry Potter and the Deathly Hallows Part 1'
Time for Young Wizards to Put Away Childish Things
There is an especially somber and scary coloration to this installment, as Harry Potter faces a perilous grown-up world.November 19, 2010 moviesReview
Movie Review | 'Harry Potter and the Half-Blood Prince'
In Latest 'Harry Potter,' Rage and Hormones
The latest big-screen iteration of the global "Harry Potter" phenomenon has begun to show signs of stress.July 15, 2009 moviesReview
Movie Review | 'Harry Potter and the Order of the Phoenix'
Hogwarts Under Siege
The latest Harry Potter movie begins with a spot of unpleasantness at the Dursleys and ends with Harry facing down Lord Voldemort.July 10, 2007 moviesReview
J. K. Rowling's Family History on 'Who Do You Think You Are?'
The genealogy show, on TLC, will also feature episodes about Bryan Cranston and Alfre Woodard this season.
August 2, 2015, Sunday
MORE ON HARRY POTTER AND: Who Do You Think You Are? (Movie) , Genealogy , Rowling, J K , TLC (TV Network) , Television , Reality Television
Dr. Seuss and the Book Review Remind Us of the Joys of Childhood Reading
This week, a children's book made a rare appearance on the cover of The New York Times Book Review. But the book is not just any children's book and Pamela Paul, the section's editor, explains why Dr. Seuss' posthumous "What Pet Should I...
July 22, 2015, Wednesday
MORE ON HARRY POTTER AND: Geisel, Theodor Seuss , Green, John (1977- ) , Hitchens, Christopher , Lowry, Lois , Rowling, J K , Russo, Maria , Books and Literature , Children and Childhood
J. K. Rowling Says Harry Potter Play Will Open Next Summer
"Harry Potter and the Cursed Child," a new stage play centered on the blockbuster series, will be staged at the Palace Theater in the West End of London.
June 26, 2015, Friday
MORE ON HARRY POTTER AND: Heap, Imogen , Rowling, J K , Thorne, Jack , Tiffany, John , London (England) , Palace Theater , Harry Potter (Fictional Character) , Theater
Review: 'The Casual Vacancy,' Based on J. K. Rowling's Novel, on HBO
The mini-series, which is set in modern day England, has appealingly odd characters and a clever adaptation, but it is not cheery or uplifting.
April 29, 2015, Wednesday
MORE ON HARRY POTTER AND: Television , Home Box Office , Rowling, J K , Kinnear, Rory , Gambon, Michael , McKenzie, Julia , The Casual Vacancy (TV Program)
J. K. Rowling's Detective Novels Set for BBC Series
"The Cuckoo's Calling" and "The Silkworm," written under the alias Robert Galbraith and featuring a one-legged former military police investigator, will form the basis of the TV adaptation.
December 11, 2014, Thursday
MORE ON HARRY POTTER AND: Rowling, J K , Great Britain , British Broadcasting Corp , Books and Literature , Television
A First Edition Auction, With the Writers Nervously Looking On
The evening sale's high price: Philip Roth's annotated first edition of "American Pastoral" sold for $80,000.
December 3, 2014, Wednesday
MORE ON HARRY POTTER AND: Auster, Paul , Muldoon, Paul , Nossel, Suzanne , Robinson, Marilynne , Roth, Philip , Rowling, J K , Carle, Eric , Caro, Robert A , Cunningham, Michael , DeLillo, Don , Egan, Jennifer , Gladwell, Malcolm , Godwin, Peter , McCann, Colum , McInerney, Jay , PEN American Center , Auctions , Books and Literature , Writing and Writers
Can 'Harry Potter' Change the World?
Recent research suggests that the impact of the "Harry Potter" series may be far more significant than a shared cultural experience and a rich vocabulary of spells. Is it possible that reading Harry Potter makes us better people?
September 17, 2014, Wednesday
MORE ON HARRY POTTER AND: Obama, Barack , Rowling, J K , Europe , Italy , United States , Books and Literature , Discrimination , Education (K-12) , Harry Potter (Fictional Character) , Homosexuality and Bisexuality , Immigration and Emigration , Psychology and Psychologists , Reading and Writing Skills (Education) , Refugees and Displaced Persons , Research
Harry Potter Casts a Spell for Tolerance
Students who read and discussed a scene from Harry Potter in which the cruel Draco Malfoy calls Hermione a "filthy little Mudblood," and her friends react with outrage reported more positive feelings about immigrants.
August 14, 2014, Thursday
MORE ON HARRY POTTER AND: Paul, Annie Murphy , Rowling, J K , Discrimination , Friendship , Harry Potter (Fictional Character) , Parenting , Research
Afraid of Heartbreak, a Celebrity Campaign Begs Scotland to Stay
With the referendum fast approaching, over 200 celebrities bolstered a campaign against Scotland's independence by signing a letter pleading with the country to remain with Britain.
August 8, 2014, Friday
MORE ON HARRY POTTER AND: Cumming, Alan , Scotland , Connery, Sean , Dench, Judi , Rowling, J K , Jagger, Mick , Stewart, Patrick , Cox, Brian , Celebrities , Referendums , Great Britain
Reading the Future of Scotland in the Stars
Celebrities have found that taking a stand either way on Scotland's independence referendum can stir anger in about half of its population.
July 23, 2014, Wednesday
MORE ON HARRY POTTER AND: International Airlines Group , McGregor, Ewan , Thompson, Emma , Rowling, J K , Murray, Andy , England , Cumming, Alan , British Airways PLC , Scotland , Bowie, David , Referendums , Celebrities , Scottish National Party , Great Britain , Connery, Sean , European Union
'Harry Potter' Book Release on ArtsBeat
All over the world, fans await the final installment. The Times reports in images and posts.
Interactive Feature
'Harry Potter,' Dissected
Manohla Dargis and A. O. Scott discuss the evolution of the "Harry Potter" movies.
The Sorcerers of Stagecraft
A decade's worth of Harry Potter movies required lots of off-screen wizards. Now the gig of a lifetime has reached its happy ending.
Reviews of the Harry Potter Books
'Harry Potter and the Deathly Hallows'The series ends not with modernist, "Soprano"-esque equivocation, but with good old-fashioned closure.
'Harry Potter and the Half-Blood Prince'The sixth volume of the series is the darkest and most unsettling installment yet.
'Harry Potter and the Order of the Phoenix'
In Book Five, the Ministry of Magic sends an agent to oversee life at Hogwarts.
'Harry Potter and the Goblet of Fire'
It is not immediately clear that "Goblet of Fire" is a step forward for the series, since it gets off to a shaky opening, but the book ends with Ms. Rowling's most lucid, well-plotted and exciting conclusion.
'Harry Potter and the Prisoner of Azkaban'
A mass murderer named Sirius Black has escaped, but Harry is preoccupied with his Quidditch match.
'Harry Potter and the Chamber of Secrets'
Harry Potter returns to the Hogwarts School for Witchcraft and Wizardry for his second year, and disaster looms.
'Harry Potter and the Sorcerer's Stone'
The first novel in the series introduces a boy, destined for greatness, who is chosen to attend the nation's elite school for training wizards and witches.
Reviews of the Harry Potter Movies
'Harry Potter and the Order of the Phoenix'
The latest Harry Potter movie begins with a spot of unpleasantness at the Dursleys and ends with Harry facing down Lord Voldemort.
'Harry Potter and the Goblet of Fire'
Childhood ends for the young wizard with the zigzag scar in the happily satisfying film adaptation of the fourth book in J. K. Rowling's series.
'Harry Potter and the Prisoner of Azkaban'
Alfonso Cuarón's adaptation more than does justice to the best of J. K. Rowling's books so far.
'Harry Potter and the Chamber of Secrets'
The demands of remaining faithful to Rowling's book inhibits this movie as it did the first Potter film.
'Harry Potter and the Sorcerer's Stone'
The most highly awaited movie of the year has a dreary, literal-minded competence, following the letter of the law as laid down by the author.
Harry Potter Web Sites
"Hogwarts of the east" goes up in China
A fine arts academy in northern China builds a new building resembling the Hogwarts school from J.K. Rowling's famed Harry Potter series. Gavino Garay reports.
Ballet Shoes
Emma Watson (Hermione from Harry Potter) stars in Ballet Shoes, a heartwarming and uplifting film based on the beloved, best-selling novel by Noel Streatfeild and featuring an award-winning cast that includes Emilia Fox, Victoria Wood, Richard Griff
Harry Potter And The Deathly Hallows-Part 2
In Part 2 of the epic finale, the battle between the good and evil forces of the Wizarding world escalates into an all-out war. The stakes have never been higher and no one is safe. But it is Harry Potter who may be called upon to make the ultimate
Harry Potter And The Deathly Hallows-Part 1
"Harry Potter and the Deathly Hallows," the seventh and final adventure in the Harry Potter film series, is a motion picture event, told in two full-length parts.Part 1 begins as Harry, Ron and Hermione set out on their perilous mission to track
Harry Potter And The Half-Blood Prince (Blu-Ray)
Blu-Ray release for Harry Potter and the Half-Blood Prince.
Rss Feeds On Harry Potter
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Get Alerts On Harry Potter
Receive My Alerts e-mails on topics covered on this page.More Alerts >>


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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
MASSENA - In addition to the typical candy, pens and pencils handed out by participants in Mondays Solidarity Parade, parade goers were also handed information from employees of Massena Memorial Hospital on why they feel the hospital should stay public and yard signs reading SAVE SLPC by employees of the St. Lawrence Psychiatric Center.
Among those supporting the psychiatric center employees were Assemblywoman Addie Jenne Russell (D-Theresa) and Senator Joseph Griffo (R-Utica).
Im part of the task force working to keep it open, and Ill be participating in a joint hearing with the Assembly and Senate on Sept. 7 in Ogdensburg, Ms. Russell said. This issue isnt as much about labor as it is having a strong community and keeping those services available for those who need them. Our unions build strong communities,but we have to compliment services, otherwise things fall out of balance.
Mr. Griffo also offered support for the Psychiatric Center, although Ogdensburg is not part of his senate district.
The senator also said, he understands, better than most, what the Ogdensburg community is currently going through.
In the area I represent over the last few years we have lost a psychiatric center and a correctional facility in Central New York, he said. If the governor doesnt understand the economic impact of these closures, he should certainly understand it impairs the ability to provide these services.
Mr. Griffo also said he has been working with Se. Patricia A. Ritchie (R-Heuvelton), who does represent Ogdensburg, to help preserve services at the center.
As for the fight to keep MMH a public hospital, Mr. Griffo said the decision whether privatize the municipal health care institution is one that should be made locally.
The community needs to come together to decide what is best for the hospital to keep it open, he said. Taking sides one way or the other isnt whats best for the community.
Ms. Russell though said in her mind privatization isnt the answer.
I know the next couple of years in health care are going to be challenging for everyone, but I dont think MMH should be targeting unions to pin the blame on, she said. This is a period of transition and to me it seems like theyre using the transition to try and break the union.
Ms. Russell said what she would like to see is the hospital administration working with its employees, rather than against them.
This is a very complicated issue, and I would like to see the hospital work with its unions to get through this, rather than using their backs to avoid making administrative changes, she said.
Teamsters Local 687 President Brian K. Hammond also said he doesnt think privatization is a good thing.
Its been owned by the public for so long and it should remain that way, he said.
And while the Teamsters dont represent employees at the psychiatric center, Mr. Hammond said that doesnt mean his members would not be affected.
The people making deliveries there, more often than not, are Teamsters, he said. There will be less delivering and people will have less disposable income to order things that are delivered to their homes.
And while they may not agree on everything, Mr. Hammond, Ms. Russell, Mr. Griffo and Central Trades and Labor Council President Ronald P. McDougall all agreed on one thing. Labor Day is a day to honor the nations working men and women.
I think Labor Day is an important event for everyone in labor, Mr. Hammond said. They need to celebrate working people and thats what Labor Day does.
Our members of organized labor are the backbone of our economy, Ms. Russell said. Their numbers are shrinking, and I find that to be problematic, so Im here to show support for the men and women who continue to fight for the middle class.
Mr. Griffo, who represents communities in Northern and Central New York, said that hard working men and women are among Upstate New Yorks greatest asset.
I think one of the most important assets in New York, whether its Northern New York or Central New York, is our workforce, he said.
Mr. McDougall, who helped to organize this years festivities, said that while hes seen bigger crowds in past years the threat of rain may have kept some people away.
Its number 33 for us, he said. The weather has cooperated, although there were some doubts as late as 7 or 8 this morning (Monday).
All in all though, as children screamed on the playground and their parents enjoyed a cold drink on their day off, Mr. McDougal said he would consider the day to be a success.
Its another successful Labor Day here in Massena, he said.
To help fund the activities, tickets are sold for a drawing is held each year with a grand prize of $10,000 awarded. Winning the grand prize this year was Sheila Ayotte of Massena. Mike Derosie of Massena won $5,000. Ed Cunningham of Massena won $1,000 and Shelly Chilton, Massena, won $500. Other prizes awarded included $400 to Dawn Jenne, of Parishville, $300 to Taylor Fuller of Potsdam, $200 to Darren Derango of Massena and $100 to Adam Bigtree of Hogansburg.
The top three parade entries as determined by this years judges, Scott Wilson, Albert Herb Deshaies and Penny Pullmain were AFG Local 1968, IBEW Local 2032 and CSEA Local 845.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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Mets want a monster package for Dickey, offering 2-year deal
The Mets want a 'monster package' for R.A. Dickey, which is likely a few high-end prospects, major leaguers, outfielders and catching help, Andy Martino says in today's Daily News.
According to Martino, citing a high-ranking MLB executive, if the Mets don't get this level return, they're probably not going to trade him.
In case you missed it this past weekend, the New York Post said the Mets and Dickey have been discussing a two-year contract extension, though Dickey is looking for more than $10 million a season.
On Saturday, Martino said Dickey is willing to accept less than $29 million for two years.
Matthew Cerrone, Lead Writer
I said last week that the Mets were not being offered as much as they hoped in a deal for Dickey. I also said last week that the Mets are likely offering Dickey a two-year deal, probably worth around $10 to $12 million a year. I have been under the impression Dickey is seeking at least three guaranteed years to start after 2013. The above reports now have me wondering if that third year is an option. If it is, that sounds like a fair deal to me. In total, it would mean Dickey is guaranteed around $30 million over the next three years (with an option), which sounds like a deal he could get this winter on the open market. I hope this works out.
In other words, which is more valuable to the Mets: a basket of mid-level prospects, who are years away, and who may or may not pan out, or Dickey for there years at $30 million? That's the equation, and it's understandable the Mets (who are shooting for 2014) would prefer Dickey. It's also understandable that Dickey would prefer to take slightly less, because who knows what 2013 has in store for him. I mean, if he were to gamble and not sign an extension, but be a bust in 2013, the market will treat him as a fluke. He'd be smart to get as much as he can now and take solace knowing his family is taken care of for many, many years.
Today, I'm going 55-45 he signs an extension and is here on Opening Day.
Last Friday, Sandy Alderson told Newsday that he would like some clarity on Dickey's and David Wright's possible contract extensions before the start of the Winter Meetings, which begin Monday, Dec. 3.


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Evaluation of Antiplatelet Drug Resistance in Taiwanese With VASP & Platelet Mapping ™ Assay
Recruitment status was Recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Currently, drugs commonly used for antiplatelet are aspirin and clopidogrel when encountering stroke or coronary heart disease. In this study, we would use VASP assay and thromboelastograph with platelet mapping assay kit to evaluate the antiplatelet resistance in general population and the relationship between clopidogrel and proton pump inhibitor.
30 Healthy People
Drug: Clopidogrel and proton pump inhibitors
Phase 4
|Study Type:
|Study Design:
|Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Screening
|Official Title:
|Evaluation of Antiplatelet Drug Resistance in Taiwanese With VASP & Platelet Mapping™ Assay
- Comparison of the antiplatelet drug response apparently shown in TEG & Platelet mapping assay [ Time Frame: 6 months ] [ Designated as safety issue: No ]
|Estimated Enrollment:
|Study Start Date:
|May 2008
|Estimated Study Completion Date:
|October 2010
|Estimated Primary Completion Date:
|October 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Clopidogrel and proton pump inhibitors
all participating healthy people should receive clopidogrel and 3 kinds of PPI sequentially with one week interval between each PPI.
Drug: Clopidogrel and proton pump inhibitors
baseline detection --> clopidogrel 75 mg PO QD for 1 week --> clopidogrel 75 mg plus rabeprazole 20mg PO QD for 1 week --> clopidogrel 75 mg PO QD for 1 week (wash-out phase) --> clopidogrel 75 mg plus pantoprazole 40mg PO QD for 1 week --> clopidogrel 75 mg PO QD for 1 week (wash-out phase) --> clopidogrel 75 mg plus esomeprazole 40mg PO QD for 1 week -->
1 week washout --> aspirin 100mg PO QD for 1 week
Other Names:
Detailed Description:
This study intent is to search the standard to diagnose of the antiplatelet drug resistance and to discover the prevalence of drug resistance in Taiwanese population in Taiwan. The trial will enroll at least 30 healthy people after fulfilling the investigation questionnaire. All the participants will receive antiplatelet drugs in two separate period and measured the efficacy by VASP assay and thromboelastograph with platelet mapping assay. The health volunteer will receive clopidogrel and different types of proton pump inhibitor to see the interference of antiplatelet efficacy between each drug.
|Ages Eligible for Study:
|20 Years to 60 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- 30 Healthy people, without major systemic disease, not under medication treatment
Exclusion Criteria:
- Systemic disease, under medication control with NSAID, anticoagulants, taking antiplatelet drugs before entering trial, Chinese herb, pregnant or breast feeding woman
Please refer to this study by its ClinicalTrials.gov identifier: NCT01023360
|Contact: Fu-Tien Chiang, MD, PhD
|886-2-23123456 ext 62150
|Contact: Jen-Kuang Lee, MD
|886-2-23123456 ext 62394
|National Taiwan University Hospital
|Taipei, Taiwan, 100
|Contact: Fu-Tien Chiang, MD, PhD 886-2-23123456 ext 62150 firstname.lastname@example.com
|Contact: Jen-Kuang Lee, MD 886-2-23123456 ext 62394 email@example.com
|Principal Investigator:
|Fu-Tien Chiang, MD, Phd
|National Taiwan University Hospital
No publications provided
|Responsible Party:
|Chiang Fu-Tien, PhD, National Taiwan University Hospital
|ClinicalTrials.gov Identifier:
|NCT01023360 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 7, 2008
|Last Updated:
|December 1, 2009
|Health Authority:
|Taiwan: Department of Health
Additional relevant MeSH terms:
Platelet Aggregation Inhibitors
Proton Pump Inhibitors
Anti-Ulcer Agents
Enzyme Inhibitors
Gastrointestinal Agents
Hematologic Agents
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Pharmacologic Actions
Physiological Effects of Drugs
Purinergic Agents
Purinergic Antagonists
Purinergic P2 Receptor Antagonists
Purinergic P2Y Receptor Antagonists
Therapeutic Uses
ClinicalTrials.gov processed this record on October 09, 2015


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Read: Steven Fogarty May Not Make The USA Team
At the United States of Hockey, Chris Peters writes that Steven Fogarty may not be ready to play for Team USA at the World Junior Championships in December.
He writes that Fogarty has been "adequate" so far at Notre Dame and he is "on the cusp" of making the team, but he may not be in a position right now to be a strong center for Team USA.
Peters does write, "there's a lot of games between now and then for Fogarty to adjust. His size and skill keep him an attractive option and I'd expect him to still earn an invite to pre-tournament camp. I'm dropping him to a 45 percent chance, which is still pretty good considering the slow start."
THIS SECTION is all about Fogarty


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18-year-old Courtney Stodden is seducing another man ... under the watchful eye of her 52-year-old husband.
The teen bride-turned-reality star got back to work on her music video for her single "Reality" over the weekend, slipping into a candy-coated costume that would even make Katy Perry blush.
In some new behind-the-scenes pics from the risque shoot, Stodden strips geeky costar Nick Uzarski of his glasses, sweater vest and dress shirt.
Courtney's much-older husband Doug Hutchison was also on hand and could be seen lingering off-camera during filming.
No word yet on when the music video will drop ... but it's sure to be interesting when it finally does.
Check out more pics from the shoot above!
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Video: Atlanta Falcons owner talks about Haslam as new Browns owner
Watch Jim Donovan's exclusive interview with Jimmy Haslam
1:45 p.m.: Jim Donovan will be interviewing Jimmy Haslam one-on-one.
Watch Jim Donovan's exclusive interview with Jimmy Haslam
1:45 p.m.: Jim Donovan will be interviewing Jimmy Haslam one-on-one.
1:42 p.m.: Joe Banner news conference scheduled for 10 a.m. Wednesday morning in Berea. Mike Holmgren expected to speak to the media later in the week.
1:40 p.m.: News conference ends.
1:36 p.m.: Haslam characterizes his dealings with Mike Holmgren as very amicable.
1:35 p.m.: Haslam says "we do want to enhance the stadium for fans." He also said earlier he has no plans to change the Browns helmets.
1:32 p.m.: Haslam says he does not want to be a distraction to Head Coach Pat Shurmur and wants him to focus on getting the team ready to play each week.
He says he will be spending a lot of time in Cleveland and says he will likely make mistakes as well as a first-time owner.
1:27 p.m.: Haslam says Banner will be involved in the day-to-day running of operations but says he will be part of any major decisions.
1:26 p.m.: Haslam says this is the only personnel change at this time. Haslam told Pat Shurmur and coaching staff no changes until the end of the season (if at all).
1:24 p.m.: Haslam confirms that Mike Holmgren will leave the organization. He says Holmgren made the decision to leave at the end of the season due to the changes that would happen in his position with Haslam's team taking a more active role in the running of the team. Holmgren will stay on until the end of the season and assist with transition including working with new CEO Joe Banner. Holmgren says he will retire at season's end.
1:23 p.m. Haslam thanks Lerner family and calls it a privilege to own the Browns.
1:21 p.m.: Haslam says we "will do everything we can to bring a winning team to the fans."
1:18 p.m.: Haslam begins to address media.
1:13 p.m.: NFL owners finish lunch. Jimmy Haslam expected to adress media shortly.
12:25 p.m.: We are expecting a news conference from the NFL owners meeting at around 1 p.m.
12:11 p.m.: Atlanta Falcons owner, Arthur Blank, tells reporters he is excited about Haslam's ownership of the Browns. He praises Haslam as a business owner and says he is excited for the future for the Browns and their fans.
11:55 a.m.: Haslam expected to arrive at Browns headquarters in Berea tomorrow along with Condoleezza Rice and Republican VP nominee Paul Ryan. Ryan and Rice have a campaign appearance later in the day in Berea at BW. Condoleezza Rice is a lifelong Browns fan.
11:50 a.m.: Jim Donovan confirms that Mike Holmgren is out as Browns President. Joe Banner will be named Browns President and CEO.
11:20 a.m.: Jim Donovan reports that it's expected the Browns will introduce Joe Banner as team president at a news conference in Berea on Wednesday. Banner is a former Eagles president who was matched with Haslam at the start of the ownership talks. He has served as an advisor to Haslam throughout the process.
11:10 a.m.: According to Jim Donovan, Haslam was in a separate room while the ownership vote took place. Once the vote was completed he entered the owners' meeting room to thunderous applause.
11:05 a.m.: Vote to approve Haslam was unanimous, 32-0. Haslam bought the Browns for $1 billion, agreeing to terms with Randy Lerner in August.
10:45 a.m.: The NFL owners have approved Jimmy Haslam as the new Browns owner. He received a rousing ovation from the NFL owners after the approval vote, according to Jim Donovan who is in Chicago.
9:45 a.m.: Owners have filed into the meeting in Chicago. The vote on Jimmy Haslam as the new Browns owner is expected to be one of the first items on the agenda. Browns President Mike Holmgren is not attending the meeting, neither is Randy Lerner. Instead, the Browns team representative is Bryan Wiedmeier.
ORIGINAL POST: The NFL owners are meeting in Chicago.
One of the items on the agenda is the approval of Jimmy Haslam's purchase of the Browns from Randy Lerner.
Haslam needs two-thirds of the vote from the NFL owners, but most people believe the vote will be unanimous.
The Voice of the Browns, Jim Donovan says don't the vote means that Haslam will now have an opportunity to dive in and take control of the business of the Browns and front office.
The players say they remain focused on building off their win last Sunday against the Bengals.
Jim Donovan is in Chicago for the meetings. Keep track of the developments in updates throughout the day.


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Nothing completes your Valentine's Day look like the perfect pucker. And you are sure to heart Lavera organic lip products.
Made with all natural ingredients, Lavera Lipstick, Lipgloss, Soft Lipliner, and Lip balm are all super gentle and chemical-free. We even carry Lip Volumizer for an ooo-la-la pout.
Beautiful Lips Lipsticks are ideal for spring, with the au courant look for lips ranging from soft and creamy (Rose Kiss, Peach Amber) to bold and vibrant (Maroon Kiss, Berry Charm). Our lipsticks have been reformulated for longer lasting color and a smoother, creamier feel. Natural plant oils of Shea butter, Cocoa butter and Coconut butter provide light yet intensive moisture, while a soothing infusion of organic flower extracts gently protect and pamper lips. We have also added Silica-mineral pigments to achieve more brilliant color.
All Lipsticks are 95% organic, just look for the NaTrue 3 star logo! Made with all natural ingredients, Lavera Lipstick, Lipgloss, Soft Lipliner, and Lip balm are all super gentle and chemical-free.
Lavera Beautiful Lips Lipstick comes in 10 gorgeously flattering hues, and we also offer two new shades of Soft Lipliner to compliment the lipsticks. Follow these simple steps to creating the perfect pucker:
- If lips are dry or flaky (and they often are this time of year) gently exfoliate with a mixture of sugar and milk. Remember to be VERY gentle on delicate lips. Always apply a moisturizing lip balm at bedtime.
- Apply SOLUTION Lip Volumizer SPF5 to lips for added moisture and to plump your pout.
- Liner helps lipstick to stay put and prevents color from bleeding into the outer edges of the lip. The key is to use a liner close to the color of your lipstick. Apply on lip line.
- Fill in lips with lipstick of your choice. Try either (or both!) of these looks for the season: Sweet and Subtle — Apricot Beige Soft Lipliner with Peach Amber Lipstick or Classic Bold — Plum Brown Soft Lipliner with Maroon Kiss Lipstick.
- If you prefer a high-gloss look, layer Transparent Lip Gloss over your lipstick.
Not sure how our new lipsticks match up to your old favorites? We have created the New Trend Color Comparison Chart to make it easy for you to try our new greener and more gorgeous colors. And don't worry, we still have our lovely Lipgloss and mouth-watering Lip balms.


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Mary T. Slaby
PAWTUCKET - Mary T. Slaby 93, of Jeanne Jugan Residence 964 Main Street passed away Sunday May 19, 2013 at Pawtucket Memorial Hospital.
Born in Central Falls she was a daughter of the late Stanley and Sophie (Koziol) Slaby.
Before retiring in 1980 Mary was employed as an Assembler for Carol Cable Co. for 44 years.
For many years Mary was a communicant and active member of St. Joseph's Parish in Central Falls, and a member of the former Ladies Auxiliary of the Orchard Lake Schools.
She is survived by nieces and nephews. She was the sister of the late Sister Mary Gemma of the Sisters Of The Resurrection, Ann Libucha, Pauline, John, Walter and James Slaby.
Her funeral will be held Today, Tuesday, May 21, 2013 at 9:30 a.m. in the Jeanne Jugan residence (Little Sisters of the Poor) 964 Main Street Pawtucket with a Mass of Christian Burial in the Chapel of the Residence at 10:30 a.m. Relatives and friends are welcome to attend. Burial will be in Mt. St. Mary's Cemetery East Providence. Arrangements by Karol A. Romenski & Sons Funeral Home.
|Mary T. Slaby for TIMES TUES obit.JPG


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Now that a few weeks have passed since our preview of fall's most covetable accessories, it's time to start thinking seriously about the footwear you want to invest in for the season. While there are an abundance of notable shoe trends you should try over the next few months, we think stocking up now on an assortment of boots is the perfect way to get the ball rolling. We've done most of the hard work for you--rounding up the season's must-have styles, including a couple of wedged pairs and equestrian versions--for this month's Market Watch story. The only tough part will be deciding which of today's covetable 13 pairs you should buy. Let the boot shopping begin!Designer Inspiration
Boots and fall fashion go together like Olympic gymnasts and glitter, so naturally designers showed a large selection of this essential footwear style this season. At
Tommy Hilfiger, a slew of below-the-knee riding boots charged the runways and made an excellent compliment to the collection's uptown, equestrian-influenced clothing. Here, the Loafer Boots ($398, 212.223.1824), worn with a collared shirt and a leather panel skirt (sadly, both pieces were not produced), are the perfect nod to the collection's Town and Country theme, resulting in a polished city-girl look we can't wait to try this fall.
For those rainy days ahead, give your wardrobe some sophisticated polish with a sleek riding boot, as seen at Gucci and Tommy Hilfiger. Wear them with a knee-length sweater dress belted at the waist for the office, or swap in tucked-in slim jeans and a button-up shirt for an afternoon errand run.
Our picks:
Burberry Leather Riding Boots ($795)
Banana Republic Willow Riding Boots ($198) in Brown
Vince Camuto Flavian Combo Boots ($210)
Whether they're metallic, worn-in leather, or suede, lace-up boots are perfectly suited for weekend jaunts around the city. To play up their combat boot heritage, go for a refined military-inspired look with a camouflage jacket.
Our picks:
Madewell The Suede Foothill Lace-Up Boots ($248)
Ecote Country Boots ($79) in Silver
MICHAEL Michael Kors Mocha Oiled Costa Addie Boots ($390, 1.866.709.5677)
Comfort and chic come to a crossroads with the wedged boot, a foot-friendly style that works well for both day and evening. Leather versions hitting at or just above the ankle look pitch-perfect with a girly frock and opaque tights.
Our picks:
Won Hundred Touch Boots ($437, available September) in Green
Jil Sander Double Monk Wedges ($895)
Kenneth Cole Collection Tres Mignon Boots ($198)
The low-heeled Chelsea boot is sure to be the new model-off-duty favorite this season. Embrace their cool-girl insouciance by styling them with a pair of black skinny jeans, a basic tee, and a little leather jacket.
Our picks:
Coach Lucia Ankle Boots ($248) in Cinnamon/Carnelian
RED Valentino Gored Flat Booties ($525)
Acne Free Boot ($630, 212.625.2828) in Ivory


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- »
- I ♥ Budapest »
- Outside Budapest
Outside Budapest
The Royal Palace
The Palace is one of the most important, largest monuments of Hungarian Palace architecture. Its builder, Count Antal Grassalkovich I (1694-1771) was a typical figure of the regrouping Hungarian aristocracy of the 18th century. He was a Royal Septemvir, president of the Hungarian Chamber, and confidant of Empress Maria Theresa (1740-1780). The construction began around 1733, under the direction of András Mayerhoffer (1690-1771) a Salzburg builder.
Szentendre is known as the town of living art due to its artist colony of international renown, and its museums and galleries. With its well preserved, distinctive 18th-century townscape, the town centre is a group of heritage buildings unique in Hungary.
Distance from Budapest: 25 km North from Budapest center
Of the approximately 1000 wine cellars standing here before World War II, nowadays about 500 are in use. Two rows created in the mid 1800's are protected heritage sites.
Royal Palace
2025 Visegrád
The excavated and reconstructed parts of 14-15th century former Palace show both Gothic and Renaissance features. For a while the official seat of the Hungarian sovereign, it later became their summer residence.
Hungary's largest church and the seat of the Catholic Church inHungary. The Classicist basilica houses a Renaissance masterpiece, the Bakócz Chapel. The Treasury's collection is extremely rich. The basilica is 118 metres long, 49 meteres wide, and 100 metres in height. Arches connect the two 57-metre towers on the left and right of the tympanum at the main entrance.
Opening hours: Mon-Sun 10 am- 4 pm (except during the Services)
Distance from Budapest: 50 km North from Budapest center
Brunszvik Kastély
Martonvásár, Brunszvik u. 2.
The Baroque mansion was reconstructed in the early 1870's in an English neo-Gothic style. Beethoven spent an extended period of time here as a guest of the Brunszvik family and a museum is dedicated to his memory.
Ruins of the Church and Monastery
2072 Zsámbék, Korvin János u.
Constructed in Romanesque style in the first half of the 13th century, then reconstructed in Gothic style, today its remains give a fair idea of how the three-aisle basilica-shaped sanctuary once looked.
Hungaroring – Mogyoród
Formula-1 Grand Prix 2011 is held on 29-31 July
Distance from Budapest:30 km North-East from Budapest center
Website: www.hungaroring.hu


text:
Directions to Shalimar Hostel
- Info
- |
- Rates
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- Map & Directions
- |
- Reviews
- |
- Facilities
Map & Directions
1401A Las Vegas Blvd S.
From California: Interstate15 North Merge onto I-15 N. Take the SAHARA AVE. exit - exit number 40 Keep right on the fork in the ramp Merge onto W. SAHARA AVE. Turn left onto S. LAS VEGAS BLVD.
From Arizona: US 93 Take the BOULDER HWY exit - exit number 70 Keep LEFT at the fork in the ramp Turn Left onto BOULDER HWY. BOULDER HWY becomes FREMONT ST. Turn SLIGHT LEFT onto E. CHARLESTON BLVD. Turn LEFT onto S. LAS VEGAS BLVD / NV-604 From Utah Interstate 15 South Take SAHARA AVE. exit Merge onto W. SAHARA AVE. .7 miles Turn Left onto S. LAS VEGAS BLVD. .8 miles
From Las Vegas McCarron Airport
By Airport Shuttle:
A variety of shuttle/limousine services are available at McCarran, and are located on the west side of baggage claim, outside door exits 7-13. Please note that there are both group shuttle and 'for-hire' stretch limousine services.


text:
- Red Bull USA - Sports & Entertainment News | Teams & Athletes
- Sports
- Action Sports
- Skateboarding
- Photos
- Twin Cities: Red Bull Mississippi Grind
- The Red Bull Mississippi Grind barge in downtown St. Paul
Add a comment
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- Sep 4, 2011
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- Copyright
- Dan Neufeld/Red Bull Media House North America, Inc.
- About this Image
Action Sports Content
Red Bull Manny Mania Pro 2009 Highlights Jul 30, 2009
In its third year, Red Bull Manny Mania will showcase more pros and bigger names involved as the Skateboard Weekend progresses to a four day affair. Skate scene legends Jeff Pang and Dave Ortiz...
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Luis Tolentino isn't just a pro skater, he also plays one on the big screen. Check out the trailer for his film 'Pablo on Wheels,' hitting a film festival near you.
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Life on the Red Bull Mississippi Grind barge skatepark isn't all glamorous, as Joey Brezinski and the rest of the skate crew realize as they're woken up by the sounds of some light construction. No...
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Joey Brezinski and Ronnie Creager join a stacked crew on the Red Bull Mississippi Grind floating barge skatepark. Tag along as the gang -- including Luis Tolentino and Kenny Anderson -- gets their...
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With Red Bull Mississippi Grind in the history books, we take a look back at the one-of-a-kind skateboarding trip, featuring a concrete skatepark on a barge floating down the Mississippi River. Check...


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Welcome to Smogon! Check out the Smogon Info Hub for everything you need to know about starting out in the community. Don't forget to introduce yourself in the Introduction Thread, too!
Welcome to Smogon Forums! Please take a minute to read the rules.
#Neverused Showdown v2.1
Discussion in 'BW NU' started by Django, Nov 1, 2012.
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18 U.S. Code § 1116 - Murder or manslaughter of foreign officials, official guests, or internationally protected persons
(a) Whoever kills or attempts to kill a foreign official, official guest, or internationally protected person shall be punished as provided under sections 1111, 1112, and 1113 of this title.
(b) For the purposes of this section:
(1) "Family" includes (a) a spouse, parent, brother or sister, child, or person to whom the foreign official or internationally protected person stands in loco parentis, or (b) any other person living in his household and related to the foreign official or internationally protected person by blood or marriage.
(2) "Foreign government" means the government of a foreign country, irrespective of recognition by the United States.
(3) "Foreign official" means—
(A) a Chief of State or the political equivalent, President, Vice President, Prime Minister, Ambassador, Foreign Minister, or other officer of Cabinet rank or above of a foreign government or the chief executive officer of an international organization, or any person who has previously served in such capacity, and any member of his family, while in the United States; and
(B) any person of a foreign nationality who is duly notified to the United States as an officer or employee of a foreign government or international organization, and who is in the United States on official business, and any member of his family whose presence in the United States is in connection with the presence of such officer or employee.
(4) "Internationally protected person" means—
(A) a Chief of State or the political equivalent, head of government, or Foreign Minister whenever such person is in a country other than his own and any member of his family accompanying him; or
(B) any other representative, officer, employee, or agent of the United States Government, a foreign government, or international organization who at the time and place concerned is entitled pursuant to international law to special protection against attack upon his person, freedom, or dignity, and any member of his family then forming part of his household.
(5) "International organization" means a public international organization designated as such pursuant to section 1 of the International Organizations Immunities Act (22 U.S.C. 288) or a public organization created pursuant to treaty or other agreement under international law as an instrument through or by which two or more foreign governments engage in some aspect of their conduct of international affairs.
(6) "Official guest" means a citizen or national of a foreign country present in the United States as an official guest of the Government of the United States pursuant to designation as such by the Secretary of State.
(c) If the victim of an offense under subsection (a) is an internationally protected person outside the United States, the United States may exercise jurisdiction over the offense if
(3) an offender is afterwards found in the United States. As used in this subsection, the United States includes all areas under the jurisdiction of the United States including any of the places within the provisions of sections 5 and 7 of this title and section 46501 (2) of title 49.
(d) In the course of enforcement of this section and any other sections prohibiting a conspiracy or attempt to violate this section, the Attorney General may request assistance from any Federal, State, or local agency, including the Army, Navy, and Air Force, any statute, rule, or regulation to the contrary notwithstanding.
Source(Added Pub. L. 92–539, title I, § 101,Oct. 24, 1972, 86 Stat. 1071; amended Pub. L. 94–467, § 2,Oct. 8, 1976, 90 Stat. 1997; Pub. L. 95–163, § 17(b)(1),Nov. 9, 1977, 91 Stat. 1286; Pub. L. 95–504, § 2(b),Oct. 24, 1978, 92 Stat. 1705; Pub. L. 97–351, § 3,Oct. 18, 1982, 96 Stat. 1666; Pub. L. 103–272, § 5(e)(2),July 5, 1994, 108 Stat. 1373; Pub. L. 103–322, title VI, § 60003(a)(5), title XXXIII, § 330006,Sept. 13, 1994, 108 Stat. 1969, 2142; Pub. L. 104–132, title VII, § 721(c),Apr. 24, 1996, 110 Stat. 1298; Pub. L. 104–294, title VI, § 601(g)(2),Oct. 11, 1996, 110 Stat. 3500.)
1996—Subsec. (a). Pub. L. 104–294struck out ", except that" at end.
Subsec. (b)(7). Pub. L. 104–132, § 721(c)(1), added par. (7).
Subsec. (c). Pub. L. 104–132, § 721(c)(2), inserted first sentence and struck out former first sentence which read as follows: "If the victim of an offense under subsection (a) is an internationally protected person, the United States may exercise jurisdiction over the offense if the alleged offender is present within the United States, irrespective of the place where the offense was committed or the nationality of the victim or the alleged offender."
1994—Subsec. (a). Pub. L. 103–322, § 330006, which directed the striking of ", and any such person who is found guilty of attempted murder shall be imprisoned for not more than twenty years" before period at end, was executed by striking text which did not include ", and", to reflect the probable intent of Congress and the prior amendment by Pub. L. 103–322, § 60003(a)(5). See below.
Pub. L. 103–322, § 60003(a)(5), struck out "any such person who is found guilty of murder in the first degree shall be sentenced to imprisonment for life, and" after "title, except that".
Subsec. (c). Pub. L. 103–272substituted "section 46501 (2) of title 49" for "section 101(38) of the Federal Aviation Act of 1958, as amended (49 U.S.C. 1301(38))".
1982—Subsec. (b)(5). Pub. L. 97–351inserted provision relating to a public organization created pursuant to treaty or other agreement under international law as an instrument through or by which two or more foreign governments engage in some aspect of their conduct of foreign affairs.
1978—Subsec. (c). Pub. L. 95–504substituted reference to section 101(38) of the Federal Aviation Act of 1958 for reference to section 101(35) of such Act.
1977—Subsec. (c). Pub. L. 95–163substituted reference to section 101(35) of the Federal Aviation Act of 1958 for reference to section 101(34) of such Act.
1976—Catchline. Pub. L. 94–467substituted "official guests, or internationally protected persons" for "or official guests".
Subsec. (a). Pub. L. 94–467inserted reference to internationally protected persons, section 1113 of this title, and the punishment for a person convicted of attempted murder.
Subsec. (b). Pub. L. 94–467designated existing provision, relating to definition of "foreign official" as par. (3)(A), (B), and added pars. (1), (2), (4), (5) and (6).
Subsec. (c). Pub. L. 94–467substituted provision permitting the United States to exercise jurisdiction over an offense if the victim is an internationally protected person and the alleged offender is present within the United States for provision which defined "foreign government", "international organization", "family", and "official guest".
Subsec. (d). Pub. L. 94–467added subsec. (d).
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


text:
Technique - Sew
This no-sew bell pattern is a breeze!The complete no-sew pattern includes step-by-step photo diagrams and instructions to create a beautiful bell ornament to decorate around the house or on your Christmas tree. Perfect for kids and adults alike, you can finish this lovely design in about an hour. A bell-shaped Styrofoam® piece is needed to secure the pins in place.
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text:
Tips: Freeing space for your music, pictures, videos, and files
You can store files in the built-in media storage on your BlackBerry smartphone or on a media card.
Check how much storage is used by media files and documents.
On the home screen, click the Media icon. Press the key > Memory Use.
Delete unneeded files.
On the home screen or in a folder, click the Files icon. Find and highlight a file. Press the key > Delete.
Reduce the size of pictures you take and videos you record.
On the home screen, click the Camera icon or the Media icon > Video Camera icon. Press the key > Options. Change the Image Size or Video Format field.
Store files on a media card instead of your smartphone.
On the home screen, click the Camera icon or the Media icon > Video Camera icon. Press the key > Options. In the Storage section, change the Store Pictures or Store Videos field.
Research In Motion recommends that you regularly create and save a backup file on your computer, especially before you update any software. Maintaining a current backup file on your computer might allow you to recover smartphone data if your smartphone is lost, stolen, or corrupted by an unforeseen issue.
Was this information helpful? Send us your comments.


text:
Project Traveller Raids
Project Traveller Raids
Parole chiave
A police officer carries a box of goods seized from the house of... Foto di attualitàCanada,Composizione verticale,Forze di polizia,Governo,Intrappolato,Legge,Mercanzia,Politica,Portare,TorontoPhotographer Rick MadonikCollection: Toronto Star 2013 Toronto StarTORONTO, ON - JUNE 13: A police officer carries a box of goods seized from the house of Muhammed Khattak. Guns and Gang task force raid a number of places in the city. Much of the activity was focused on buildings on Dixon Road. One of the places also investigated was the home of Muhammed Khattak, the third person seen in the photograph with Mayor Rob Ford outside of 15 Windsor Road. Police launched a massive predawn raid on June 13, 2013, targeting guns and drugs. The focus is on the Toronto neighbourhood thats ground zero for the Mayor Rob Ford crack video scandal. (Rick Madonik/Toronto Star via Getty Images)


text:
greeting cards, thomas jefferson greeting cards, potus greeting cards, president of the united states greeting cards, portraits greeting cards, portriat greeting cards, us president greeting cards, us presidents greeting cards, u.s president greeting cards, u.s presidents greeting cards, presidents greeting cards, popart greeting cards
"THOMAS JEFFERSON in BLUE" greeting card by ROB HANS. Ships within 2 - 3 business days and includes a plain white envelop for mailing and/or gift giving. Available in vertical and horizontal orientations.
Rob Hans was born in New York City in 1967. As one of five children, he grew up in a typical family environment. He enjoyed playing sports, and had an early appreciation for music although he barely played any musical instruments. His musical tastes range from the classics of the '50s to heavy metal, with a little bit of everything else in between. As a young man, he was a volunteer firefighter for over 7 years and then joined the U.S. Navy and was home-ported in Japan and San Diego. Rob has been to 18 countries and more than 30 U.S. States. Rob is a veteran of the Persian Gulf War and is a life member of the V.F.W. and the D.A.V. Since Rob was never really able to find his true calling as far as a career, he has held several...
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text:
Smith Optics
Phenom Snow Goggles
Out of Stock Product Number: 28363
Uncompromising in design, the Smith Phenom packs superior technology and timeless style into their best fitting goggle ever.
* This product does not qualify for shipping to all countries.
- Spherical, Carbonic-X Lens with TLT Optics
- Articulating Outrigger Positioning System
- Patented Vaporator Lens Technology with Porex™ Filter
- Patented Regulator Adjustable Lens Ventilation
- Interchangeable Hop-Up Kits
- Ultra-Wide, Silicone Backed Strap
- QuickFit Strap Adjustment System with Clip Buckle
- Dual Layer, DriWix Face Foam
- Helmet Compatible
- Microfiber Bag Included
Gender: Unisex
Fit: Medium Fit
Season: F13
Vendor ProductId: PH6IBT11
Review ProductId: 28363


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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
Is the Black River Valley Club haunted?
Thats the question nearly 20 paranormal investigators with a little help from a Times reporter and photographer for part of the night sought to answer as they combed the century-old building at 131 Washington St. late Saturday and throughout the wee hours of Sunday.
Were excited to come in here, Lana M. Putnam, founder and lead investigative advisor of Paranormal Investigations of the St. Lawrence Seaway, said Saturday night before embarking on the night-long investigation. Weve heard a lot of good things.
The Potsdam-based group conducted the probe in conjunction with Scotia-based Uini Research, but both groups will review evidence collected separately.
In an email Sunday, Ms. Putnam said the investigation resulted in activity of interest on every level of the club, including temperature changes, unexplained noises and shadows and even shadowy figures seen in the basement and elsewhere.
However, video and audio recordings have yet to be reviewed, and plans are to reveal full results of the investigation as a fundraiser for the American Red Cross on Sept. 28 at the downtown club.
Were out to give back to the community, said Ms. Putnam, noting that her team is self-funded and frequently supports non-profit organizations through such presentations.
The Black River Valley Club is an outgrowth of the Union Club, which was organized in 1876. The present building was completed in 1907 at the site of the former home of then-club member Dr. G.S. Farmer.
Amanda Phillips, event coordinator at the Black River Valley Club, said the weekend investigation was suggested as a way to substantiate a litany of bizarre experiences of club members, staff and other visitors.
The people that work here are used to it, said Ms. Phillips, who served as host for the overnight visitors and assisted in the investigation.
Servers at the club often notice items that are inexplicably moved or misplaced, only to turn up again later, she said.
Club Manager David F. Boucher on one occasion misplaced his car keys and, despite unsuccessfully checking his pockets multiple times at the club, found them there later upon returning home, Ms. Phillips said.
I have definitely smelled tobacco smoke, and so have other people, she added.
Ms. Phillips also noted a visit from a psychic medium a couple of years ago when the stereo turned on inexplicably, another time when the system appeared to play radio-based music, despite not being connected to a radio, and one night when workers were unable to turn off the lights in the clubs cabaret room.
A motion alarm also went off once when nobody was inside, and several people have experienced the feeling of being watched while alone in the building, she said.
Crews prepared for the investigation by setting up infrared cameras throughout the three-story building and its ill-kept basement, which bears some resemblance to haunted sites designed by Hollywood.
Investigators also spent a considerable amount of time using handheld devices to record temperature readings for both the rooms and surfaces, as well as any electromagnetic activity, then following up later with similar sweeps. Readings were collected both on notepads and voice recorders for redundancy.
I want proof, Ms. Putnam said. I want facts.
Team members are given few facts about a buildings history or unusual occurrences in advance and asked not to share their feelings or notions while the investigation is ongoing, she said.
We come in cold to any location, the group leader said. We dont want anything to taint our investigation.
While the groups rely on mediums, Ms. Putnam said their efforts are heavily based on science and the scientific method, with much of their time spent trying to find natural explanations for odd occurrences. Its not paranormal, its wiring, she said. Its a gas leak, not a ghost.
While members of Ms. Putnams group spent a lot of time joking with each other and even considered using a white sheet found in the basement to scare other investigators, they said they are very serious about the work and hope their efforts bring comfort to those on both sides of the spectral plane.
Ill be 90 and still doing this, Ms. Putnam said. It always amazes me.
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text:
20 U.S. Code § 7182 - Definitions
As used in this part:
(2) Children's services
The term "children's services" means the provision on a routine or regular basis of health, day care, education, or library services—
(A) that are funded, after January 8, 2002, directly by the Federal Government or through State or local governments, by Federal grant, loan, loan guarantee, or contract programs—
(i) administered by either the Secretary of Health and Human Services or the Secretary of Education (other than services provided and funded solely under titles XVIII and XIX of the Social Security Act [42 U.S.C. 1395 et seq., 1396 et seq.]); or
(B) that are provided in indoor facilities that are constructed, operated, or maintained with such Federal funds, as determined by the appropriate head of a Federal agency in any enforcement action carried out under this part,
(4) Person
The term "person" means any State or local subdivision of a State, agency of such State or subdivision, corporation, or partnership that owns or operates or otherwise controls and provides children's services or any individual who owns or operates or otherwise controls and provides such services.
Source(Pub. L. 89–10, title IV, § 4302, as added Pub. L. 107–110, title IV, § 401,Jan. 8, 2002, 115 Stat. 1773.)
References in Text
The Child Nutrition Act of 1966, referred to in par. (2), is Pub. L. 89–642, Oct. 11, 1966, 80 Stat. 885, as amended, which is classified generally to chapter 13A (§ 1771 et seq.) of Title 42, The Public Health and Welfare. For complete classification of this Act to the Code, see Short Title note set out under section 1771 of Title 42 and Tables.
The Social Security Act, referred to in par. (2)(A)(i), is act Aug. 14, 1935, ch. 531, 49 Stat. 620, as amended. Titles XVIII and XIX of the Act are classified generally to subchapters XVIII (§ 1395 et seq.) and XIX (§ 1396 et seq.), respectively, of chapter 7 of Title 42, The Public Health and Welfare. For complete classification of this Act to the Code, see section 1305 of Title 42 and Tables.
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