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7 U.S. Code § 7701 - Findings
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Congress finds that—
(1) the detection, control, eradication, suppression, prevention, or retardation of the spread of plant pests or noxious weeds is necessary for the protection of the agriculture, environment, and economy of the United States;
(2) biological control is often a desirable, low-risk means of ridding crops and other plants of plant pests and noxious weeds, and its use should be facilitated by the Department of Agriculture, other Federal agencies, and States whenever feasible;
(3) it is the responsibility of the Secretary to facilitate exports, imports, and interstate commerce in agricultural products and other commodities that pose a risk of harboring plant pests or noxious weeds in ways that will reduce, to the extent practicable, as determined by the Secretary, the risk of dissemination of plant pests or noxious weeds;
(4) decisions affecting imports, exports, and interstate movement of products regulated under this chapter shall be based on sound science;
(5) the smooth movement of enterable plants, plant products, biological control organisms, or other articles into, out of, or within the United States is vital to the United State's [1] economy and should be facilitated to the extent possible;
(6) export markets could be severely impacted by the introduction or spread of plant pests or noxious weeds into or within the United States;
(7) the unregulated movement of plant pests, noxious weeds, plants, certain biological control organisms, plant products, and articles capable of harboring plant pests or noxious weeds could present an unacceptable risk of introducing or spreading plant pests or noxious weeds;
(8) the existence on any premises in the United States of a plant pest or noxious weed new to or not known to be widely prevalent in or distributed within and throughout the United States could constitute a threat to crops and other plants or plant products of the United States and burden interstate commerce or foreign commerce; and
(9) all plant pests, noxious weeds, plants, plant products, articles capable of harboring plant pests or noxious weeds regulated under this chapter are in or affect interstate commerce or foreign commerce.
[1] So in original.
Source(Pub. L. 106–224, title IV, § 402,June 20, 2000, 114 Stat. 438.)
References in Text
This chapter, referred to in pars. (4) and (9), was in the original "this title", meaning title IV of Pub. L. 106–224, June 20, 2000, 114 Stat. 438, which is classified principally to this chapter. For complete classification of title IV to the Code, see Short Title note set out below and Tables.
Short Title
Pub. L. 106–224, title IV, § 401,June 20, 2000, 114 Stat. 438, provided that: "This title [enacting this chapter, amending section 7759 of this title and section 129a of Title 21, Food and Drugs, and repealing sections 148, 148a, 148c to 148f, 149, 150, 150a to 150g, 150aa to 150jj, 151 to 154, 156 to 164, 164a, 167, 1651 to 1656, and 2801 to 2813 of this title, and provisions set out as notes under sections 147a, 150, 150aa, 151, and 1651 of this title] may be cited as the 'Plant Protection Act'."
Pub. L. 106–224, title IV, § 451, as added by Pub. L. 108–412, § 1,Oct. 30, 2004, 118 Stat. 2320, provided that: "This subtitle [subtitle E (§§ 451–457) of title IV of Pub. L. 106–224, enacting subchapter V of this chapter] may be cited as the 'Noxious Weed Control and Eradication Act of 2004'."
Transfer of Functions
For transfer of functions of the Secretary of Agriculture relating to agricultural import and entry inspection activities under this chapter to the Secretary of Homeland Security, and for treatment of related references, see sections 231, 551 (d), 552 (d), and 557 of Title 6, Domestic Security, and the Department of Homeland Security Reorganization Plan of November 25, 2002, as modified, set out as a note under section 542 of Title 6.
Regulations To Improve Management and Oversight of Certain Regulated Articles
Pub. L. 110–234, title X, § 10204,May 22, 2008, 122 Stat. 1343, and Pub. L. 110–246, § 4(a), title X, § 10204,June 18, 2008, 122 Stat. 1664, 2105, provided that:
"(a) In General.—Not later than 18 months after the date of enactment of this Act [June 18, 2008], the Secretary [of Agriculture] shall—
"(1) take action on each issue identified in the document entitled 'Lessons Learned and Revisions under Consideration for APHIS' Biotechnology Framework', dated October 4, 2007; and
"(2) as the Secretary considers appropriate, promulgate regulations to improve the management and oversight of articles regulated under the Plant Protection Act (7 U.S.C. 7701 et seq.).
"(b) Inclusions.—In carrying out subsection (a), the Secretary shall take actions that are designed to enhance—
"(1) the quality and completeness of records;
"(2) the availability of representative samples;
"(3) the maintenance of identity and control in the event of an unauthorized release;
"(4) corrective actions in the event of an unauthorized release;
"(5) protocols for conducting molecular forensics;
"(6) clarity in contractual agreements;
"(7) the use of the latest scientific techniques for isolation and confinement distances;
"(8) standards for quality management systems and effective research; and
"(9) the design of electronic permits to store documents and other information relating to the permit and notification processes.
"(c) Consideration.—In carrying out subsection (a), the Secretary shall consider—
"(1) establishing—
"(A) a system of risk-based categories to classify each regulated article;
"(B) a means to identify regulated articles (including the retention of seed samples); and
"(C) standards for isolation and containment distances; and
"(2) requiring permit holders—
"(A) to maintain a positive chain of custody;
"(B) to provide for the maintenance of records;
"(C) to provide for the accounting of material;
"(D) to conduct periodic audits;
"(E) to establish an appropriate training program;
"(F) to provide contingency and corrective action plans; and
"(G) to submit reports as the Secretary considers to be appropriate."
[Pub. L. 110–234and Pub. L. 110–246enacted identical provisions. Pub. L. 110–234was repealed by section 4(a) ofPub. L. 110–246, set out as a note under section 8701 of this title.]
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subset: commoncrawl


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Photo by Pornchai Mittongtare
YIELD: Makes 4 servings
ACTIVE TIME: 20 minutes
TOTAL TIME: 20 minutes
- 1 pound nectarines (about 4 medium), halved, pitted, thinly sliced
- 2 1/2 cups fresh raspberries, divided
- 1/2 cup sugar, divided
- 4 large egg yolks
- 1/3 cup canned peach nectar
- 1/4 cup peach liqueur
- Pinch of salt
- Toasted sliced almonds (optional)
Toss nectarines, 2 cups raspberries, and 1/4 cup sugar in medium bowl. Let stand until juices form, about 5 minutes.
Whisk egg yolks, nectar, liqueur, salt, and 1/4 cup sugar in large metal bowl to blend. Place bowl over saucepan of boiling water; whisk until mixture is thick and thermometer inserted into center registers at least 160°F, about 6 minutes.
Divide fruit mixture among 4 large glasses. Spoon warm peach sabayon over. Garnish with remaining berries and sliced almonds, if desired.
One serving contains the following: 243.94 Calories (kcal), 17.6% Calories from Fat, 4.77 (g)
Nutritional analysis provided by Self


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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
CANTON - Town resident Margaret A. Hockett held a book signing at Brewer Bookstore Saturday afternoon to promote her first novel, Taking Hart.
I didnt know what to expect. This is my first signing, she said.
Several small groups gathered during the two-hour signing to hear Ms. Hockett read excerpts from the novel, a modern thriller in which a teenager tries to uncover dangerous secrets from the War of 1812.
Debra L. Thornton, a former classmate of Mrs. Hockett, came down from Toronto for the event.
We went to school together, she said. Margaret was always smart, artistic, and creative.
Mrs. Hockett grew up in Edwards. She moved to California in 1984, where she spent much of her career as an editor for The Critical Thinking Co., a publishing company that produces educational books and software. She returned to the north country in 2006, and now resides in Canton.
It was after returning to the area that she first had the idea for Taking Hart, incorporating local history into an exciting story.
I was looking at the fictional standpoint, which was kind of exciting, then I saw all of the historical strands that I could weave in, she said.
She worked with a historian to make sure the stories from 1812 were historically accurate.
The book, written under the pseudonym M.A. Noble, is set in a fictional small town in the Thousand Islands, founded by privateers after the War of 1812. The story is filled with references to people and places in the north country, both modern and historic, real and fictional.
People like to read about things they know about, Mrs. Hockett said.
Rather than working with a traditional publisher, Ms. Hockett decided to self-publish the novel, producing it more quickly and releasing it in time for the 200th anniversary of the War of 1812.
The e-book became available on Amazon.com and elsewhere over the summer, and Mrs. Hockett is working through North Country Books Inc. to distribute the novel to local bookstores.
While her editing experience made self-publishing doable, Ms. Hockett says she needs to learn a lot about promotion and marketing before she can fully succeed as an author without a traditional publisher. This book signing was one of the first steps.
I feel like Im not doing nearly enough, she said.
She recently wrote and self-published a book based on her fathers memories of growing up in St. Lawrence County throughout the 20th century, and is already at work on the sequel to Taking Hart.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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Flash 1/4 Zip (Boy's) (out-of-stock)
Out of Stock Product Number: 22968
The boy's Marmot Flash 1/4 Zip is a news flash! Velvety velour fleece looks and feels like a million bucks, and flat lock seam construction makes it perfect for all-season layering. In winter, he'll get plenty of use from the handy cuff nose wipes. Durable poly fibers will last through countless wash cycles.
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Material: 100% Polyester Velour Fleece 4.0 oz/yd
Season: F11 F13
Vendor ProductId: 83040
Review ProductId: 22968


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Global Best Pictures
Pope Francis drives through the crowds during the Inauguration Mass... News PhotoBestof,Bestpix,Ceremony,Crowd,Horizontal,Human Interest,Inauguration Into Office,International Landmark,Mass,People,Politics,Pope,Pope Francis,Religion,Spirituality,St Peter's Square,State of the Vatican City,Topics,Topix,Vatican CityPhotographer Spencer PlattCollection: Getty Images News 2013 Getty ImagesVATICAN CITY, VATICAN - MARCH 19: Pope Francis drives through the crowds during the Inauguration Mass for the Pope in St Peter's Square on March 19, 2013 in Vatican City, Vatican. The mass is being held in front of an expected crowd of up to one million pilgrims and faithful who have filled the square and the surrounding streets to see the former Cardinal of Buenos Aires officially take up his role as pontiff. (Photo by Spencer Platt/Getty Images)


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TKB Radio Tonight with Anthony Donahue & Alex Kennedy of HoopsWorld
Check out TKB Radio with Anthony Donahue at 9PM tonight.
Anthony's guest tonight will be Alex Kennedy of Hoopsworld.
You can call in the show (646)-478-5554 and talk everything New York Knicks!
CLICK HERE to listen to the show


text: Utah Jazz player Jarron Collins takes a time out to sign autographs and pose for pictures with Nico, Tony, and Nathan Velasquez during his visit to Carbon County last Friday. Collins is currently visiting athletic centers across Utah sharing his knowledge of basketball with Utah youth. During his stop in Price, Collins participated in a shooting contest with the kids and also shared stories of his experience as a NBA star.


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The purpose of this policy statement is to establish the requirements necessary to prevent or minimize accidental or intentional unauthorized access or damage to university information resources. This policy balances the responsibility for information security with the need to foster an open and information-sharing atmosphere among members of the academic community.
This policy applies to all university students, faculty and staff, affiliates, third-party support contractors, and all others granted access to NIU information resources. All users of information resources bear responsibility for the protection of those assets. Based on system and information classification categories defined in this policy, some categories of users have a greater burden of responsibility and accountability than others.
This policy pertains to all university information resources, whether the resources are individually or departmentally controlled, enterprise managed, stand-alone or networked. It applies to all computer and communication facilities owned, leased, operated or contracted by the university, networking devices, personal digital assistants, telephones, wireless devices, workstations, mainframes, minicomputers, portable storage devices and any associated peripherals and software, whether used for administrative, research, teaching or other purposes. It applies to personal computers that are used to access, store or maintain university information. This policy also pertains to hard-copy documents that are classified under these guidelines.
Section headings are:
The purpose of information security is to protect the information resources of the university from unauthorized access or damage. The underlying principles followed to achieve this objective are:
All university information, including electronic and hard-copy records, is assigned to stewards, who classify it by the level of sensitivity and risk. These classifications take into account the legal protections (by statute or regulation), contractual agreements, ethical considerations and proprietary worth. Information can also be classified as a result of the application of "prudent stewardship," where a legal mandate to protect such information is lacking, but reasonable discretion may be required in its disclosure, as in the Sensitive Information classification described below.
The classification level assigned to information guides information stewards, end users, business and technical project teams, and others who may obtain or store information, in the security protections and access authorization mechanisms appropriate for that information.
Information classifications are as follows:
Relationship to Personal Information Security
Data that contains personally identifiable information (PII), mandates that a higher level of security must be applied for its protection. As information becomes more anonymous and there is less personally identifiable information, then less rigorous measures are required.
Relationship to Other Information Assets
When the appropriate level of protection is determined, that same level of protection shall be applied to all other related information in whatever format, wherever retained (e.g., servers, network segments, desktop computers, mobile devices and storage devices such as jump drives, CD or DVD, and physical storage units such as rooms/spaces, desk drawers and file cabinets).
The retention and destruction of information and records are governed by federal and state legal standards (such as, the Illinois State Records Act). To determine specific security safeguards for each information classification, consult the NIU Information Security Procedures.
Adherence to the principles of information security set forth in this policy requires the participation and involvement of the entire university community. In particular, state law mandates that the university notify individuals when there is a breach of the security of system information or written material which contains their "personally identifiable information," as defined by the law. Because of the legal requirement to protect this information, such personal information should be treated as Restricted Information. NIU employees who are aware of any attempted or actual breach are required to report the incident to the Division of Information Technology (DoITS) Security Office at 815-753-8100 for investigation and potential breach notification.
Within the framework of these principles, the responsibilities of those in key positions, as well as other members of the campus community, are as follows:
University systems, both hardware and software, are classified by scope and level of support and by impact on university operations. The classification of systems takes into account legal protections (by statute or regulation), contractual agreements, ethical considerations, and strategic or proprietary worth of information maintained in such systems. The classification level assigned to systems will guide system and data stewards, and business and technical project teams in the security protections and access authorization mechanisms appropriate for those systems. Such categorization provides the basis for planning, allocation of resources, support, and security/ access controls appropriate for those systems.
The system classifications are as follows:
Information and records, whether maintained in electronic files or on paper, must be stored and disposed of securely, in accordance with the State Records Act and the Electronic Commerce Security Act, ref. 5 ILCS 160/17; and P.A. 90-759, sect. 5-135(a)(1).
NOTE: Pursuant to applicable State and/or Federal requirements (e.g. Federal Rules of Civil Procedure, etc.) ALL information and records subject to a litigation hold must be retained in whatever format the information is in and in whatever classifications notwithstanding other general policies on retention.
Violations of this policy include, but are not limited to: accessing information to which the individual has no authorization or business purpose; enabling unauthorized individuals to access information; disclosing information in a way that violates applicable restricted access or confidentiality procedures, or handling or using information contrary to any other relevant regulations or laws; inappropriately modifying or destroying information or university business records; inadequately protecting Restricted Information or Sensitive Information; or ignoring the explicit requirements of information stewards for the proper management, use and protection of information resources. In coordination with divisional authorities, violations may result in network removal, access revocation, corrective action, university disciplinary action and/or civil or criminal prosecution, if applicable. Should disciplinary action be implemented, up to and including dismissal, suspension or expulsion, such actions will be taken pursuant to applicable university policies and procedures.
Divisional authorities will be notified in the event that a university office or department is found to have generally violated this policy (beyond actions taken by an individual employee). Corrective actions and possible financial costs associated with an information security incident will be coordinated at the division level.
Third-party vendors and/or consultants found to have breached their respective agreements with the university may be subject to consequences, including but not limited to, the loss of third-party vendor/consultant access to university information technology resources, removal of the vendor/consultant from university facilities, termination/cancellation of the agreement, payment of damages, and criminal or civil charges based on the nature of the violation.
The university is sometimes required to transmit information by state or federal forms and formats. When using such forms and formats, university employees should transmit such information following university policy and utilize appropriate safeguarding and security measures in the transmission of that information. It is important to work with state and federal officials in striving to meet industry best practices in the transmission of information.
In some instances the university is mandated to disclose, or authorized to release information that would normally be protected under this policy. Examples include, but are not limited to, disclosures pursuant to state or federal reporting requirements, legal process (such as subpoenas, court orders, warrants, etc.), disclosures pursuant to the Illinois Freedom of Information Act (FOIA), and certain authorized releases of information about particular individuals (students, employees or customers).
Legal Process
Any employee or affiliate of the university who is served with a legal document (for example, a subpoena, summons, court order, warrant, etc.) that refers to university records or data shall notify University Legal Services immediately and prior to the release of any requested information. University Legal Services will review the legal document to determine the validity and enforceability of the document, and to provide guidance and assistance in properly responding.
Legal documents that are addressed to a particular person should be accepted only by that person. If an unintended recipient is served with the legal document, it should not be accepted. The process server or deliverer should be referred to the person identified on the document, by name, title or job description, or should be directed to University Legal Services.
FOIA Requests
All requests for access to or release of records or data under the Illinois Freedom of Information Act (FOIA) should be referred to the Freedom of Information Officer within University Legal Services for appropriate review of the request. FOIA requests must be in writing. University Legal Services will coordinate the collection of information that is properly responsive to the request, especially when information from multiple university offices is requested.
Requests from External Entities and Persons, including Law Enforcement and Attorneys
The university receives numerous requests for information and records maintained by the university from persons and entities that are external to the university. The release of information about a particular person may require authorization by that person. Publicly available information about individuals and other types of information that can be released are available at the university's web pages: http://www.niu.edu. University Legal Services and the Office of Public Affairs are available to assist with evaluating the validity and scope of any authorization provided for the release of information, as well as providing guidance for appropriately responding to information requests pursuant to an authorization.
External law enforcement agencies sometimes request information. Before responding to these requests, University Legal Services and the Department of Public Safety should be contacted to determine the authenticity of the request and the requestor. In addition, any request for information from an attorney, whether by legal process or not, should be immediately referred to University Legal Services.
All other requests for information from outside entities or persons should be evaluated on a case-by-case basis. University Legal Services and the Office of Public Affairs are available for assistance in this area. For identifying information or data stored in an electronic format at NIU, the Information Security Office is available for assistance.
The duties and responsibilities of university employees with regards to information protection and safeguarding are defined by numerous documents, including but not limited to, state and federal laws and regulations, university policies and procedures, and industry standards and best practices. Since information security is a growing and evolving area, the Information Security Office, with cooperation from University Legal Services, will constantly monitor for new developments and maintain a listing of relevant resources on this topic.
Northern Illinois University (NIU) Information Security Policy
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10 U.S. Code § 2779 - Use of funds because of fluctuations in currency exchange rates of foreign countries
(a) Transfers Back to Foreign Currency Fluctuations Appropriation.—
(1) Funds transferred from the appropriation "Foreign Currency Fluctuations, Defense" may be transferred back to the appropriation—
(A) when the funds are not needed to pay obligations incurred because of fluctuations in currency exchange rates of foreign countries in the appropriation to which the funds were originally transferred; and
(b) Funding for Losses in Military Construction and Family Housing.—
(1) One hundred million dollars, plus $25,000,000 from Family Housing, Defense, are appropriated to the Secretary of Defense, to remain available until spent. The appropriation is available only to provide funds to eliminate losses in military construction or expenses of family housing for the Department of Defense caused by fluctuations in currency exchange rates of foreign countries that changed after a budget request was submitted to Congress.
(2) Funds provided under this subsection are merged with and are available for the same purpose and for the same time period as the appropriation to which they are applied. An authorization or limitation limiting the amount that may be obligated or spent is increased to the extent necessary to reflect fluctuations in exchange rates from those used in preparing the budget submission.
(c) Transfers to Military Personnel Accounts.— The Secretary of Defense may transfer funds to military personnel appropriations for a fiscal year out of funds available to the Department of Defense for that fiscal year under the appropriation "Foreign Currency Fluctuations, Defense".
(d) Transfers to Foreign Currency Fluctuations Account.—
(1) The Secretary of Defense may transfer to the appropriation "Foreign Currency Fluctuations, Defense" unobligated amounts of funds appropriated for operation and maintenance and unobligated amounts of funds appropriated for military personnel.
(2) Any transfer from an appropriation under paragraph (1) shall be made not later than the end of the second fiscal year following the fiscal year for which the appropriation is provided.
Source(Added Pub. L. 97–258, § 2(b)(8)(B),Sept. 13, 1982, 96 Stat. 1056; amended Pub. L. 101–510, div. A, title XIII, § 1301(15),Nov. 5, 1990, 104 Stat. 1668; Pub. L. 104–106, div. A, title IX, § 911(a)–(c), (e), Feb. 10, 1996, 110 Stat. 406, 407.)
|Revised section
|Source (U.S. Code)
|Source (Statutes at Large)
|July 25, 1979, Pub. L. 96–38, § 100 (last par. under heading "General Provisions"), 93 Stat. 100.
|Nov. 30, 1979, Pub. L. 96–130, § 100 (par. under heading "Foreign Currency Fluctuation, Construction, Defense"), 93 Stat. 1019.
In subsection (a)(1), before clause (A), the words "during the current fiscal year or on and after July 25, 1979" are omitted as executed. The words "from an appropriation to which they were transferred" are omitted as surplus. In clause (A), the words "of foreign countries" are added for consistency.
In subsection (a)(2), the words "back to the Foreign Currency Fluctuations, Defense appropriation" are substituted for "authorized by this provision" for clarity.
In subsection (b)(1), the words "the sum of", "which shall be derived", and "to appropriations and funds" are omitted as surplus. The word "only" is added for clarity. The words "for those appropriations or funds" are omitted as surplus. The words "available during fiscal year 1980, or thereafter" are omitted as executed. The words "Department of Defense" are substituted for "military departments and Defense agencies" because of 10:101(5).
In subsection (b)(2), the words "or fund" are omitted as surplus. The words "now or on and after November 30, 1979" are omitted as executed. The words "contained within appropriations or other provisions of law", "hereby", and "applicable" are omitted as surplus.
In subsection (b)(3), the words "contracts or other . . . entered into" are omitted as surplus.
Prior Provisions
Provisions similar to those in subsec. (d) of this section were contained in Pub. L. 97–377, title I, § 101(c) [title VII, § 791], Dec. 21, 1982, 96 Stat. 1865, which was set out as a note under section 114 of this title, prior to repeal by Pub. L. 104–106, § 911(d)(2).
1996—Subsec. (a). Pub. L. 104–106, § 911(e)(1), inserted heading.
Subsec. (a)(2). Pub. L. 104–106, § 911(e)(2), substituted "second fiscal year" for "2d fiscal year".
Subsec. (b). Pub. L. 104–106, § 911(e)(3), inserted heading.
Subsec. (c). Pub. L. 104–106, § 911(a), added subsec. (c).
Subsec. (d). Pub. L. 104–106, § 911(b), added subsec. (d).
Subsec. (e). Pub. L. 104–106, § 911(c), added subsec. (e).
1990—Subsec. (b)(4). Pub. L. 101–510struck out par. (4) which read as follows: "The Secretary each year shall report to Congress on funds made available under this subsection."
Effective Date of 1996 Amendment
Pub. L. 104–106, div. A, title IX, § 911(f),Feb. 10, 1996, 110 Stat. 407, provided that: "Subsections (c) and (d) ofsection 2779 of title 10, United States Code, as added by subsections (a) and (b), and the repeals made by subsection (d) [repealing provisions set out as a note under section 114 of this title], shall apply only with respect to amounts appropriated for a fiscal year after fiscal year 1995."
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text:
Final Sale
Sophie Theallet Preppy Cardigan
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- From our Sophie Theallet® Collection
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- Hand wash, line dry.
- Imported
Item# 5633646


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By RICHARD SHAWSun Advocate publisher
Each day when I put words on paper to write for this paper I think about them.
Each day when a business or personal finance problem comes across my desk and I must use math skills to solve it I think about them.
Each day when I meet someone, whether it be in person, on the phone or over the internet, from a far away place, and I know where that is I think about them.
Who I think about are teachers I had when I went to school.
Each day, as adults in our society, we perform tasks that may seem mundane and simple, but so many of those things we do require skills we learned from someone.
Getting dressed, brushing our teeth and combing our hair may be things we learned from our parents; but a lot of what we seem to inherently know comes from teachers we had at one time or another.
While the greatest teacher we have in life may be experience, the basis for that experience comes from somewhere, and often it is from the education we received as a child. Through those daily tasks we tend to forget that the skills to complete them were taught to us.
I have often thought about where the most important part of my education came from. Like a house, a skill or the ability to perform a complex task needs a foundation. I have to say my mother and my youngest sister helped prepare me well for school before I went to kindergarten. I can remember as a four to five year old sitting with my sister in my room where she had set up a little blackboard teaching me the letters and simple numbers. She even taught me to spell psychology when I was five, and loved to have me spell it in front of her friends and our relatives.
So unlike many kids I was probably ahead of things when I entered kindergarten in 1957. But it was in school where those early skills were honed.
Teachers are important to us for our future. When I was a kid if something I was involved in went wrong in the classroom, you can bet my parents asked me "What did you do to cause this?" or "Did you create the problem?"
Today it seems most parents want to blame the teacher in the classroom for their kids problems, when the biggest influence in a kids life is his parents. People who blame teachers for all their kids ills ought to hold up a mirror to their faces and ask those questions.
When I was young I wanted to be a teacher; I held what they did in high regard. They were professionals, just like physicians, lawyers and engineers. Today we act like they are commodities, to be bought and sold, hoping to get the lowest bid we can, to get one to fill a classroom.
But these are the people who we entrust our children with, our most valuable resource and for many of us the only reason life is worth living. Our legislature acts like it is so generous when it gives more money for teachers, whether it be to increase the number of hires or for salaries. Yet they should give a lot more.
To some, those that have never tried it, teaching seems to be a cake job. On the surface it looks that way; seven hour days, three months off a year, many holidays and breaks, good benefits and a certain paycheck. Those are some of the good things about teaching.
But those same people who hold teachers up to ridicule also ought to think about the hot days in classrooms with 30 smelly kids, half of which who have parents who think school is just a baby sitting service and make no effort to help their kids education along.
They ought to be there at parent teacher conferences when parents tell the teacher the reason their kid is not learning is because of the teaching.
Never mind that mom loses herself in television all night after the kid comes home from school and dad downs a six pack and smokes a joint before eight o'clock.
They ought to be there when kids come in battered and bruised and the teacher has to report it to the authorities because it looks like the child is being abused. Talk about angry parents.
They ought to be there when a disruptive child messes up the entire day for 20 other students, yet the teacher has little recourse but to keep that child in their class.
They ought to be there when the teachers name is scrawled in chalk on the sidewalk outside their classroom with expletives and suggestions of what that teacher is or does.
The point is, nothing looks as hard to do as it is. And teaching is no exception.
Sure there are bad teachers, and some have large faults. Most are good and got into the profession because they want to make a difference in kids lives.
But beyond that there is nothing wrong with expecting to be paid what you are worth and that is why this state loses so many good teachers to other states. We talk a good story in Utah about our commitment to quality education, but we do little with dollars to back that up.
We keep producing more and more kids, and expect to keep teachers for less and less money.
It's time the public rose up and told the legislature that education needs to be our main priority, and to spend more time and consideration on that instead of working on bills concerning how big our neighbors garden shed is or whether someone is going to drink a beer flavored like a pineapple in the park on a Sunday afternoon.
As you watch many of the legislators comments and interviews about any legislative session, you can come to one conclusion.
Certain legislators, actually a good number of them, hate the media first, and teachers second.
We in the media accept the fact they hate us, but we don't do this job to feel the love; it is part of what we signed on for. But teachers? What did they ever do to gain that kind of disdain?
Remember the good that teachers did for you and then remember to do good for them.
Be a pain in the neck to the legislature so they will provide good pay for teachers and enough teachers to educate our kids and grandkids.


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Stanford White
Kings Notable New Yorkers, Office for Metropolitan History
The architect Stanford White could conjure elegance. Marine serpents for porch brackets, a Colonial bed warmer used as a panel decoration, inchworm-shaped screen perforations, keystones bursting into flames: these were the products of his genius as much as majestically proportioned ballrooms or Renaissance-style facades.
His Villard houses, at Madison Avenue and 50th Street, feature dreamy blue- and white-veined marble, cut in one instance into a great scallop shell — a hypnotic quarter-sphere of blue cheese.
And the astonishing mirrored Venetian Room in the house built for Payne Whitney, at Fifth Avenue and 78th Street, has a series of porcelain flowers woven into the gilt basket-weave screen that forms the ceiling.
Born in New York on Nov. 9, 1853, White was accomplished early at drawing and painting, and soon showed remarkable design ability. He joined forces with Charles McKim and William Mead in 1879, and within a short time the firm was at or near the top of architectural practice in America, with contracts even in its earliest years for the Newport Casino, the Villard Houses in New York and other major projects.
The buildings and other structures in Manhattan that White had primary responsibility for designing for the firm include the second Madison Square Garden (demolished in 1925), the Metropolitan Club, the Century Club, the Judson Memorial Church and the Washington Square Arch.
Throughout the McKim, Mead & White partnership, McKim played the intellectual, learned classicist, poring over reference books; Mead, the steady hand on the business side; and White, the impulsive creative genius, always in a hurry but completely assured in his ideas.
Despite White's success, the last decade of his life (he died in 1906) was a maelstrom of spiraling debt, compulsive buying and troubled health, masked all too well by an exuberant good nature. In an 1899 letter, he wrote that he faced ''debtor's prison'' over cost overruns on his own Gramercy Park house. In 1905 a warehouse fire destroyed $250,000 worth of furniture and artwork that he had planned to sell to offset bills of over half a million dollars.
In his mid-40s, White, who was married but had a penchant for young girls — he liked to give them rides on a red velvet swing he kept in the apartment he used for his adulterous affairs — took up with a 16-year-old model and chorus girl named Evelyn Nesbit. He introduced Nesbit to high culture and fine food, lavished financial support on her family and invited her over for rides on the swing. She became his mistress.
In 1906, the Pittsburgh millionaire Harry K. Thaw, whom Nesbit had married the year before, shot and killed White in a jealous rage in the rooftop restaurant of the very Madison Square Garden that White and his firm had designed.
Highlights From the Archive
Streetscapes | Lexington Avenue at Gramercy Park North
On the Trail of Stanford White
Stanford White's own residence, a renovated brownstone on Lexington Avenue at Gramercy Park North, is now long gone.October 26, 2008 realestateNews
Beauty and the Beasts
A revisionist look at the woman whose husband murdered Stanford White.June 1, 2008 booksReview
Flatiron District
The Girl, the Swing and a Row House in Ruins
A hideaway built for seduction has collapsed, taking with it the setting of a rich and bizarre Manhattan narrative.November 4, 2007 nyregionNews
Streetscapes | 25 East 78th Street
An Elegant Design to Complement a Bold Personality
A Stanford White house purchased last year by Mayor Michael Bloomberg is probably the most distinguished surviving mansion on upper Madison Avenue.August 19, 2007 realestateNews
The Arts/Cultural Desk
Love Triangle at the Garden
When the eccentric millionaire Harry K. Thaw shot and killed the famed architect Stanford White on the roof of the old Madison Square Garden almost a century ago, the subsequent ''trial of the century'' was a perfect storm of celebrity scandal.June 22, 2005 artsReview
Real Estate Desk
Stanford White Design, Elsie de Wolfe Interior
When its clubhouse went up in 1907, designed by Stanford White, the Colony Club instantly became the premier women's social club in New York.September 28, 2003 realestateNews
Real Estate Desk
A Skeptic's View of a Renowned Architectural Firm
Mosette Broderick has spent much of her professional life studying McKim, Mead & White for her book ''When Architecture Could Fashion a Nation,'' to be published by Alfred A. Knopf.September 23, 2001 realestateNews
Long Island Weekly Desk
Stanford White and His Life Under Scrutiny Of Descendant
Stanford White, the architect of the Gilded Age who was celebrated in life and notorious after death, is not as famous as he used to be.September 22, 1996 booksBiography
Real Estate Desk
A Spectacular Interior Designed by Stanford White
Few people know one of New York's most spectacular interiors. It's the 1899 Gould Memorial Library, at New York University's old uptown campus, on 180th Street between Sedgwick and University Avenues -- now Bronx Community College.March 24, 1996 realestateNews
Plans for a Memorial to Honor Tesla
Admirers have bought the crumbling laboratory on Long Island where Nikola Tesla worked and are planning to raise $10 million to restore it to house a museum and memorial.
May 3, 2013, Friday
MORE ON STANFORD WHITE AND: Tesla, Nikola , Tesla Science Center at Wardenclyffe , Long Island (NY) , White, Stanford , Agfa
Old, Massive, Illustrious and Somehow Overlooked
Few today notice the giant 1902 powerhouse at the foot of East 74th Street, or have heard of George H. Pegram, the engineer who designed it.
May 20, 2012, Sunday
MORE ON STANFORD WHITE AND: New York City , Historic Buildings and Sites , Consolidated Edison Inc , White, Stanford
Old, Massive, Illustrious And Somehow Overlooked
Few today notice the giant 1902 powerhouse at the foot of East 74th Street, or have heard of George H. Pegram, the engineer who designed it.
May 17, 2012, Thursday
A Rare Listing On Fifth Avenue
TAKE a mansion for sale on a singular block of Fifth Avenue, designed by a Gilded Age architect whose work defined an aesthetic that forever changed the landscape of the well-to-do corners of New York, throw in a $49 million price tag, and you have a...
June 26, 2011, Sunday
Big Deal | A Rare Fifth Avenue Mansion Goes on the Market
The house at 973 Fifth, designed by Stanford White, is for sale for $49 million.
June 22, 2011, Wednesday
MORE ON STANFORD WHITE AND: News , White, Stanford , Housing and Real Estate , Mansions , Brown Harris Stevens , Fifth Avenue (NYC)
Putting a Stamp on New York's Architecture
"Triumvirate," by Mosette Broderick, is a star-studded social and architectural narrative of America's Gilded Age.
January 16, 2011, Sunday
MORE ON STANFORD WHITE AND: Architecture , Books and Literature , New York City , White, Stanford
The Architect Charles McKim, Designer of the Morgan Library
The reopening of the J. P. Morgan library, and a new book, cast a spotlight on the architect Charles McKim, who is often overshadowed by his scandalous partner Stanford White.
October 31, 2010, Sunday
MORE ON STANFORD WHITE AND: Morgan Library & Museum , McKim, Charles , White, Stanford , Historic Buildings and Sites , Books and Literature
Gilded-Age Monuments and Secrets
A theme of Augustus Saint-Gaudens' life was his enduring friendship with the architect Stanford White.
November 8, 2009, Sunday
MORE ON STANFORD WHITE AND: Metropolitan Museum of Art , Saint-Gaudens, Augustus , Sculpture , White, Stanford
The Building Denies It Ever Met That Showgirl
The Evelyn, an 1885 apartment house, wasn't named after Stanford White's mistress, Evelyn Nesbit, despite the rumors.
November 1, 2009, Sunday
MORE ON STANFORD WHITE AND: Historic Buildings and Sites , White, Stanford , Nesbit, Evelyn
Stanford White's Backdrop for the Panic of 1907
The Panic of 1907 and the sad case of Charles Tracy Barney helped sew the seeds for the mutilation of his superb 1903 bank at Fifth Avenue and 34th Street, designed by Stanford White.
March 8, 2009, Sunday
MORE ON STANFORD WHITE AND: Historic Buildings and Sites , White, Stanford
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text:
Prospective Metabolic Monitoring of Youth and Adults With Bipolar Disorder
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Background: Most psychotropic medications that are effective in the treatment of Bipolar Disorder (BD) are associated with endocrine-metabolic changes (EMCs). To date, there is no long-term study in BD that has examined specifically the association of inflammation with EMCs in BD. Specific aims: 1) to identify predictors of EMCs among adolescents and adults with BD who are being started on a medication ; 2) to compare change in EMCs in youth and adults treated for BD; 3) to measure change in EMCs associated with use of different medications for BD. Research Design: Participants: 30 adolescents (14-18 years old) with BD and 30 adults (19-65 years old) with BD. Measures: Blood levels of biomarkers that are associated with EMCs will be measured.
Bipolar Disorder
|Study Type:
|Study Design:
|Observational Model: Case Control
Time Perspective: Prospective
|Official Title:
|Prospective Metabolic Monitoring of Youth and Adults With Bipolar Disorder.
- Change in metabolic syndrome components [ Time Frame: Screening, week 4/visit 2, week 12/visit 3, week 52/final visit ] [ Designated as safety issue: No ]i.e. weight glucose, lipids, blood pressure, etc.
- Cytokines, Chemokines, Insulin, Prolactin, Thyroid Hormone [ Time Frame: Screening, week 4/visit 2, week 12/visit 3, week 52/final visit ] [ Designated as safety issue: No ]
- Cytokines include: pro-inflammatory markers such as c-reactive protein, interleukin-6, and tumor-necrosis factor alpha; anti-inflammatory cytokines include interleukin-4
- Chemokines include: Leptin, Ghrelin and Adiponectin
|Study Start Date:
|January 2011
|Study Completion Date:
|September 2013
|Primary Completion Date:
|January 2013 (Final data collection date for primary outcome measure)
|Individuals aged 14-18 and 19-65 with a diagnosis of BD
|Ages Eligible for Study:
|14 Years to 65 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Thirty adolescent participants with BD (type I, II, or not otherwise specified), and 30 adult participants with BD will be enrolled. Participants with BD will be recruited from the Youth and Adult Mood Disorder Clinics. Psychiatry Division staff will identify patients who meet the study criteria during weekly treatment team meetings. New referrals will also be screened to identify potential participants.
Inclusion Criteria:
- Provision of written informed consent
- Diagnosis of BD type I, II, or NOS as determined by DSM-IV diagnostic criteria (confirmed using SCID or K-SADS)
- Both females and males, age14 to 65 years
- Decision by physician and patient to initiate pharmacotherapy with a traditional mood stabilizer or atypical antipsychotic
- Able to understand and comply with requirements of the study
- Proficient in English.
Exclusion Criteria:
- A primary psychiatric disorder other than bipolar disorder I, II or NOS (comorbid Axis I or II disorders are permitted, as long as clinician judges that bipolar disorder is the primary condition)
- Initiation of an antipsychotic, mood stabilizer or other medication with known endocrine-metabolic effects within 4 weeks prior to baseline visit
- Patients who, in the investigators opinion, are unlikely to adhere to pharmacotherapy for at least 4 weeks after baseline visit
- Significant medical condition that would contraindicate the use of mood stabilizers or atypical antipsychotics
- Patients who are receiving pharmacological treatment for diabetes mellitus (DM), hyperlipidemia, or obesity
- Acute or chronic medical illness (e.g. urinary tract infection, bronchitis, rheumatoid arthritis) that, as judged by the investigator, would significantly alter inflammatory, metabolic, or endocrine indices
- Screening bloodwork that identifies any other clinically significant deviation from the reference range in clinical laboratory test results, as judged by the investigator.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01282281
|Canada, Ontario
|Sunnybrook Health Sciences Centre
|Toronto, Ontario, Canada, M4N 3M5
|Principal Investigator:
|Ayal Schaffer, MD
|Sunnybrook Health Sciences Centre
|Principal Investigator:
|Benjamin Goldstein, MD
|Sunnybrook Health Sciences Centre
No publications provided
|Responsible Party:
|Dr. Ayal Schaffer, Head, Mood & Anxiety Disorders Program; Deputy Psychiatrist-in-Chief, Department of Psychiatry; Associate Professor, University of Toronto, Sunnybrook Health Sciences Centre
|ClinicalTrials.gov Identifier:
|NCT01282281 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 21, 2011
|Last Updated:
|January 16, 2014
|Health Authority:
|Canada: Health Canada
Keywords provided by Sunnybrook Health Sciences Centre:
Bipolar Disorder
Endocrine-metabolic changes
Additional relevant MeSH terms:
Bipolar Disorder
Affective Disorders, Psychotic
Mental Disorders
Mood Disorders
ClinicalTrials.gov processed this record on October 09, 2015


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KNocked two more out tonight. I really wanted to do some gold colors in there but I'd need to mix some tan with some golden yellow, and I have zero tan. So black it is.
Drew Brees
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Form 1099-G - Certain Government Payments. Use Form 1099-G Recipient Copy B to print and mail payment information to recipients. All 1099-G forms are 3up on an 8 1/2 x 11" sheet with a 1/2" side perforation and printed on 20# laser paper. Order by the number of forms needed, not the sheet. Mail in envelope #W2GENV05.
Learn More about Form 1099-G >


text:
Submission StarCraft II opens NA servers to SEA/ANZ players->
dotarray writes: Australian fans of StarCraft II, rejoice. You, along with your New Zealand and South East Asian brethren, will be able to access the North American Battle.net servers from this Thursday, September 23. That's when the upcoming Patch 1.1.0 for StarCraft II: Wings of Liberty will be launched, including a handy region selector, so you'll be set to go without needing any extra downloads.
Link to Original Source
Link to Original Source


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A bear track on Montana Creek.
A view on Glenn Highway.
A bull moose at Eielson Air Force Base.
A reindeer at North Pole, Alaska.
A sled dog at Denali.
Nagley's General Store.
A trail sign on Montana Creek has a small yellow warning about bears.
Lower slopes of Mount McKinley.
Two locals in Talkeetna.
A float plane on Fish Lake.
Larry poses with a salmon on the Talkeetna River.


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What is the base of your irrigation system?
Order within 0hrs 0mins for same-day shipping!
*Not available with backorder/drop-ship items. See Shipping Policy
The Hunter MP Rotator is a unique, revolutionary, water-conserving product that is unlike anything in the irrigation industry.
With technology that is second to none, Hunter has developed an ultimately designed, feature packed nozzle that provides superior efficiency at a lower cost. The Hunter MP Rotator is a multi-stream rotor in proportion to the size of a spray nozzle.
This revolutionary product will fit any conventional spray head body, therefore transforming into matched precipitation at any radius and arc. If you desire to conserve water and increase effieciency, then the Hunter MP Rotator is right for you.
The MP1000 Rotator is a 8-15' (2.5-4.6 meter) sprinkler (including the 25% radius reduction* capability) that fits any conventional spray head body or shrub adapter.
*To achieve maximum radius reduction with any MP1000 model, use a 30 PSI (2 BAR) pressure regulating spray body.


text:
The High Street Attempts To Entice In Christmas Shoppers
A shopper looks at wooly hats for sale at a stall in a Christmas... Fotografia de notíciasBristol - Inglaterra,Chapéu,Cliente,Finanças,For Sale - Frase em inglês,Horizontal,Inglaterra,Lã,Mercado de Natal,Natal,Negócio empresarial,Negócios,Olhar,Reino UnidoPhotographer Matt CardyCollection: Getty Images News 2012 Getty ImagesBRISTOL, ENGLAND - DECEMBER 10: A shopper looks at wooly hats for sale at a stall in a Christmas market on December 10, 2012 in Bristol, England. With internet shopping still on the rise, many traditional retailers claim this Christmas could be the one that will determine the future of the high street. (Photo by Matt Cardy/Getty Images)


text:
Hornady® Pistol .357 Sig® 124 Grain JHP / XTP 20 rounds
Item # WX2-71207
- Google+
- Details & Specs
Hornady Custom Pistol Ammunition.
All Hornday Custom pistol ammo is loaded with either the famous Hornady XTP® (eXtreme Terminal Perfromance) Bullet. All are supremely accurate, and deliver dependable knockdown power.HIGHEST QUALITY BRASS:
Much of the brass is made by Hornady, the rest is carefully selected for reliable feeding, corrosion resistance, hardness and the ability to withstand maximum chamber pressures.POWDER:
Each powder is matched with each load to ensure optimal pressure, velocity, volume and consistency from lot to lot.PRIMERS:
Like the powder, each primer is carefully matched to its load. All are chosen to their ability to quickly, completely, and reliably ignite the powder.Pistol ammunition:
Expand 1 1 / 2 times their original diameter for large channels, deep, terminal penetration.
Order ONLINE Today!
HORNADY® PISTOL AMMOStock No. 71207:
- Bullet Caliber: .357 Sig Ammo
- Bullet Wt. Grains: 124
- Bullet Style: JHP/XTP
- Muzzle Vel. (F.P.S.): 1,350
- Muzzle Energy (Ft.-lbs.): 502
- Rounds Per Box: 20 rounds
FP = Flat Point RN = Round Nose JHP = Jacketed Hollow Point FMJ FP = Full Metal Jacket Flat Point Cowboy = Cowboy Bullet FMJ RN = Full Metal Jacket Round Nose XTP = Extreme Terminal Performance
Please Note: We do not accept returns of Ammunition for safety reasons. NEVER use any Ammunition unless it is specifically designed for your firearm.
- Reviews
Hornady Pistol .357 Sig 124 Grain JHP / XTP 20 rounds is rated out of 5 by 2.Rated 5 out of 5 by GEORGE from A Great home protection round for my sig 229.Date published: 2012-12-11Rated 5 out of 5 by DANIEL R from its a very dpependable round , & is avery hot round , that shoots very well !!!Date published: 2011-12-05
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text:
Some people build their wardrobes methodically, contentiously acquiring specific pieces as a part of their master plan. Others tend to shop in a more impulsive manner, preferring to fall in love organically, even if the sum of their selections adds up to an armoire full of random buys. Regardless of whether you prefer structure or spontaneity, one thingÂ's for sure: your closet already contains the necessary pieces to create the seasonÂ's best runway looks.
Before you roll your eyes or decide that weÂ've lost our marbles, we must point out that weÂ're aware that the previous statement sounds extraordinary. That said, we also know that if you closely consider some of springÂ's key styles, youÂ'll realize that these outfits often contain at least one essential item you already own. Using this logic, itÂ's easy to breath new life into those classic or basic articles of clothing. Just by styling an old favorite in an of-the-moment way or adding a few inexpensive, trendy touches, you can recycle those beloved pieces into cool new looks.
Bearing this in mind, we tackled two spring collectionsÂ--Isabel Marant and BalmainÂ--to see if we could create our own versions of the looks. Consider it our thrifty version of Runway to Real Way, inspired, in part, by the current contents of our closets!
Isabel Marant
We started with a look from Isabel MarantÂ's Spring 09 runway, as the designerÂ's casually chic style is both highly desirable and relatively easy to emulate. The foundation of this look is an unfussy pair of lightweight gray sweatpants, which we assume most of our readers already own. (If not, try H&MÂ's Drawstring Sweatpants ($13), shown above.)
The next necessary item is a classic camel trench, another piece you might already own, but if not, we like the simplicity of Old Navy's Belted Trench Coat
($50). The finalÂ--crucialÂ--requirement for achieving the Marant look is a slouchy pair of black high-heeled boots. While the shoes shown on the runway are out of most price leagues ($1050, at Curve, 212.966.3626), itÂ's not difficult to track down a likeminded pair. We pulled type Z's Amy Boots
($129) for this story, but certainly the options abound!
You Have: H&M Drawstring Sweatpants ($13)
Go Buy: Old Navy Belted Trench Coat
($50), type Z Amy Boots
Our next runway to real-way ensemble, courtesy of Balmain, is slightly edgier and in the vein of Kate Moss or Carine RoitfeldÂ's glam-rock style. Despite the collectionÂ's luxe look, you can get the same sort of effortlessly cool outfit through a simple combination of to key pieces. First, we will be so bold as to assume that you can count a sharp black blazer as one of your closetÂ's assents. (If not, try H&M's Blazer ($50), shown above.)
With this necessary requirement in hand, just pair it with this seasonÂ's popular, bleached-out, thrashed jeans. We like bebeÂ's Carmen Rolled & Destroyed Skinny Jeans ($139), but feel free to customize a pair of your own. Then, as a final nod to the Balmain runway, pick up a pair of fashion-forward, studded heelsÂ--perhaps the Aldo Molavi Sandals ($125), pictured above? Throw it all together and voila! Last seasonÂ's blazer looks relevant again and youÂ've got a new, Balmain-inspired outfit!
You Have: H&M Blazer ($50)
Go Buy: bebe Carmen Rolled & Destroyed Skinny Jeans ($139), Aldo Molavi Sandals ($125)


text:
The Federal Government will Become America's Model Employer for the 21st Century.
Recruit, Retain and Honor a World-Class Workforce to Serve the American People.
Human Resources and Security Specialists should use this tool to determine the correct investigation level for any covered position within the U.S. Federal Government.
OPM's Human Resources Solutions organization can help your agency answer this critically important question.
Developing senior leaders in the U.S. Government through Leadership for a Democratic Society, Custom Programs and Interagency Courses.
Visit this federal site to search for our regulatory notices, proposed and final rules.
See the latest tweets on our Twitter feed, like our Facebook pages, watch our YouTube videos, and page through our Flickr photos.
If you remarry before age 55, your health benefits enrollment will end on the last day of the month preceding the month in which you remarry. However, if you were married for 30 years or more to the deceased employee or annuitant, your health benefits enrollment will continue. If you are enrolled in Self and Family coverage when your annuity ends, the enrollment will continue for any eligible children as long as one of them is entitled to receive a survivor annuity (but you will not be covered).
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text: Epic Records [ Ca$h Out Introduces His Blue-Haired Mother, Rakim Re-Releasing 'Paid in Full' LP & More By Georgette Cline June 6, 2012 Ca$h Out, the rapper with the No. 1 song on the Billboard R&B/Hip-Hop Songs chart with "Cashin' Out," introduces his mother during a radio interview. In... Read More Category: Hip-Hop Tags: Cah Out, CahOut, Cash Out, cash out mom blue hair, cash out mother, CashOut, CashOutMomBlueHair, CashOutMother, cee lo green fool for you, CeeLoGreenFoolForYou, eric b and rakim paid in full, eric b. and rakim, EricBAndRakim, EricBAndRakimPaidInFull, Kendrick Lamar, KendrickLamar, Melanie Fiona, melanie fiona cee lo green, MelanieFiona, MelanieFionaCeeLoGreen, nciki minaj, NcikiMinaj, paid in full album, PaidInFullAlbum Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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Welcome to Smogon! Check out the Smogon Info Hub for everything you need to know about starting out in the community. Don't forget to introduce yourself in the Introduction Thread, too!
Welcome to Smogon Forums! Please take a minute to read the rules.
Smogon Photo Album
Discussion in 'Smogon's Greatest Hits' started by DM, Jun 26, 2006.
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text: Nick Perkins, K2 Radio News [ Demonstrators Occupy Casper, Briefly [AUDIO, PHOTOS] By Daniel Sandoval October 10, 2011 The demonstrations that have occupied Wall Street for more than three weeks have made it to Casper. Read More|Comment Category: Casper News, National News, Photos, Politics, Wyoming News Tags: corporate greed, demonstrators, Josh Thompson, Koch, Occupy Casper, R.C. Johnson, wall street Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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Nebraska Apple store is actually a classroom
Shannon Mullen
Aug 28, 2013 It's the first student-run Apple Store for aspiring marketers, accountants, and entrepreneurs.
A new, cheap iPhone from Apple?
Ben Johnson
Interview by
Aug 13, 2013 Apple is expected to roll out new iPhones next month, and rumor has it a cheap one is on the way.
Apple, Samsung patent fight drags on
David Weinberg
Aug 9, 2013 The Apple-Samsung patent case in front of an appeals court on Friday differs from the Apple-Samsung patent dispute before the U.S. International Trade Commission.
Apple's White House pals
Ben Johnson
Interview by
Aug 6, 2013 What's behind the Obama administration's decision to overturn an International Trade Commission ban in favor of Apple?
In blow to Samsung, White House vetos ITC ban on Apple products
Krissy Clark
Aug 5, 2013 Samsung has lost more than a billion dollars in market value this morning after the White House overturned a patent victory for the company that favors rival Apple.
Apple and Samsung locked in patent wars
Sarah McCammon
Aug 1, 2013 Apple and Samsung have been locked in a series of bitter patent disputes. A ruling on one of those battles is expected from the U.S. International Trade Commission today.
The smartphone killed the camera. Is the GPS unit next?
Sally Herships
Jul 31, 2013 Garmin and other GPS companies are struggling to sell consumer GPS units in an iPhone world.
How accurate are Apple's critics? Latest report on Apple's supply chain raises questions
Rob Schmitz
Jul 30, 2013 Critics are starting to question some details in a report released Monday by the New York-based China Labor Watch, which targeted Chinese factory conditions of Apple supplier Pegatron.
Is Samsung treading water until the Galaxy S5?
Shannon Mullen
Jul 26, 2013 Even though Samsung is still growing , its profits likely won't ease concerns the company is in a bit of trouble.
Second Avenue subway construction undermines NYC small businesses
Mark Garrison
Jul 26, 2013 New York has waited nearly a hundred years for a second subway line on the east side of Manhattan. But protracted construction is hard on small businesses along the route.


text: Research In Motion, whose BlackBerry phones pioneered wireless email, no longer holds the commanding heights in the smartphone market. With Android, iOS, and even Windows Phone gaining market share, the Waterloo, Ontario, company finds itself in a battle for relevancy. The past year has been especially hard on the once-innovative RIM, but it may be at a turning point. Or the beginning of the end.


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Watertown City Court Judge Eugene R. Renzi has ruled that insurance carriers can be liable for removal and cleanup costs for vehicles that break through ice and end up submerged in water.
Watertown attorney H. Charles Livingston Jr. brought a small-claims action against Nationwide Insurance in an attempt to be reimbursed $6,465 for costs to retrieve his 2012 John Deere Gator from the St. Lawrence River in February. Mr. Livingstons son was operating the all-terrain vehicle when it broke through ice and sank.
According to court documents, Mr. Livingston called state Department of Environmental Conservation officials as he drove to the accident scene on the day it happened and was told that he had a short time to act to get the Gator out of the river.
He contacted Hunt Underwater Specialties, Watertown, which assessed the situation and determined that a small amount of oil had leaked from the vehicle, although the longer it remained submerged, the greater the chance of more leakage. The ATV was removed two days later.
On the day after the accident, Mr. Livingston contacted his insurance agent, who testified at a bench trial that she never told him removal costs were covered under his policy. Ultimately, his claim was denied because he was not being sued by anyone over the damage and there were no third-party damages being claimed, meaning Mr. Livingston was not insured for the removal costs, according to the company.
Mr. Livingston countered that his quick actions had mitigated further damage, contending that had he not removed the ATV, the DEC would have, likely at far greater expense and that Nationwide would have been obligated to pay that third-party claim.
Judge Renzi agreed, citing state Navigation Law that held Mr. Livingston liable for the vehicles removal and cleanup costs. He said that Mr. Livingston acted responsibly and in accordance with the laws intent by removing the Gator promptly.
Turning to the language in Mr. Livingstons coverage policy, the judge said he found no reference to damages being limited only to actions brought by a third party and, if that was Nationwides intent, it had an obligation to express that in clear and unmistakable language.
He said that, even though DEC did not take action against Mr. Livingston, Nationwide clearly would have been liable to the State for the expenses incurred had Mr. Livingston not done what he did. Judge Renzi said that for the company not to cover the costs would be a breach of the policy.
In addition, it would put policyholders in the recognized untenable position of having to either thwart the Navigation Laws goal of prompt cleanup of threats to navigable waters, or forfeit the insurance coverage maintained for such circumstances, Judge Renzi wrote in decision issued Monday.
He awarded Mr. Livingston a $5,000 judgment, the maximum recoverable in a small-claims case.
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|Suspect prompts police chase
|Written by Lauren Ohnesorge
|Tuesday, 12 June 2007 08:46
A traffic check over the weekend resulted in a police chase on highway 321.
19-year-old Theodore Richardson of Blowing Rock pulled over at the roadblock, which took place near the Chick-Fil-A in Boone early Saturday. As an officer approached the vehicle, Richardson allegedly sped away in his vehicle, going so far as to swerve towards an officer, prompting swift action by Boone Police. A police chase led to the Blue Ridge Parkway entrance where Richardson lost control when attempting to turn. While the suspect refused to be tested for intoxication, police believe alcohol to be the reason for his erratic behavior. Richardson was detained at the Watauga County Jail on a variety of charges including assault with a deadly weapon, driving while license revoked, driving while impaired, careless and reckless driving. He was held on a $5,000 secured bond.
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COLTON Armed with a rifle, Sawyer M. Pignona headed to the Colton-Pierrepont Central School parking lot Monday afternoon to scope it out for a fight, state police said.
Once there, police said, the Hannawa Falls teenager brandished the weapon from a car window, causing a panic that sent the school into lockdown and landing himself behind bars.
Troopers charged Mr. Pignona, 16, with a felony count of criminal possession of a weapon on school grounds, state police Investigator Christopher M. Nye said. A friend who allegedly drove Mr. Pignona to the school, Connor I. Warden, 17, Potsdam, also was charged with criminal possession of a weapon on school grounds.
Police said they are aware of a possible Facebook feud involving students from Colton-Pierrepont and other districts, and are looking into the matter.
I know there was a spat, Mr. Nye said, adding that Mr. Pignona, a Potsdam Central School student, may have taken it to the next level.
The teens were arrested separately Monday, and both were arraigned in Colton Town Court. Mr. Pignona was sent to St. Lawrence County jail, Canton, in lieu of $10,000 bail or $20,000 bond. Mr. Warden was released on $5,000 bail, Mr. Nye said.
Mr. Warden told state police that he drove the armed Mr. Pignona to Colton-Pierrepont about 3:50 p.m. Monday, according to court documents.
We left Sawyers house and he told me that we were going to a parking lot to scope it out for a fight, Mr. Warden said in a police deposition. Before we left Sawyers house he grabbed a long gun from his house and two red bandannas, Mr. Warden said. Sawyer told me where to go and we ended up at Colton school.
There, Mr. Warden said, they pulled into a back lot and observed three kids in the back of the school. Mr. Pignona opened the passenger-side window and stuck the gun out, Mr. Warden told police, although he said he was not sure whether Mr. Pignona actually aimed it at the youths. Mr. Warden said Mr. Pignona told him that the gun was not loaded.
A teacher, James A. Nee, told police in his deposition that he was coaching lacrosse when he saw a vehicle approaching about 4 p.m. The vehicle turned and backed away, but Mr. Nee noticed that the passenger rolled his window down and thrust out what appeared to be a rifle.
All students were then brought into the building and all doors were locked, Colton-Pierrepont Superintendent Joseph A. Kardash wrote in a statement posted on the districts Facebook page and website. Once the police arrived to secure the premises, parents were called to pick up students and after-school activities were cancelled.
Mr. Warden told police that he and Mr. Pignona then went back to Sawyers house and hung out for a while.
On the way back, I asked Sawyer why he pointed the gun out the window, and he told me that it does not matter, Mr. Warden said.
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Wragge Headlines MVC's All-Bench Team; Chatman On Most-Improved List
ST. LOUIS -- Junior Ethan Wragge of Creighton and senior
Jeff Early of Southern Illinois headline the list of selections for the 2013
Missouri Valley Conference specialty teams for men's basketball. Wragge,
a native of Eden Prairie, Minn., has been tabbed the conference's Team Captain
for the All-Bench Team, while Early, a native of Glasgow, Va., is the league's
Team Captain for the Most-Improved Team.
The Most-Improved Team also includes Creighton sophomore Austin Chatman.
The teams, which were selected by the league's newspaper beat writers, are comprised of a minimum of five student-athletes (top five vote-getters, plus ties) on each squad.
Wragge has averaged 7.8 points and 2.5 rebounds per game in
16.8 minutes per game (all off the bench) for the regular-season champion
Creighton Bluejays. He ranks fourth in the MVC with 68 three-pointers
made and sixth with 43.0 percent marksmanship from downtown. Wragge owns
three games with six or more three-pointers this season and nine games in
double-figures. He is joined on the team by D.J. Balentine of Evansville;
Matt Bohannon of UNI; Nathan Scheer of Missouri State; Khristian Smith of
Indiana State and Nick Wiggins of Wichita State.
In his second year at Southern Illinois, Early has improved his statistics in every category, including scoring (8.6 ppg to 13.1 ppg), rebounding (3.8 rpg to 7.4 rpg), FG percentage (.453 to .512), 3FG percentage (.176 to .250), FT percentage (.614 to .735), steals (1.2 to 1.7). The senior has eight double-doubles on the season after recording one last year. He leads the nation in rebounding among players 6-foot-1 and under. He is joined on the Most-Improved Unit by Creighton's Chatman, Illinois State's Johnny Hill, and Bradley teammates Walt Lemon, Jr., and Dyricus Simms-Edwards.
Chatman went from 2.4 points and 1.9 assists per game as a freshman to 7.7 points and 4.3 assists per game and a spot in the starting line-up for the league champion. A native of The Colony, Texas, Chatman also shot 46.4 percent from three-point range.
Creighton (24-7, 13-5 MVC) opens MVC Tournament play on Friday at 12:05 pm against the winner of Thursday night's game between Bradley and Drake.
Student-Athlete, School
*Ethan Wragge, Creighton
D.J. Balentine, Evansville
Matt Bohannon, UNI
Nathan Scheer, Missouri State
Khristian Smith, Indiana State
Nick Wiggins, Wichita State
Student-Athlete, School
*Jeff Early, Southern Illinois
Austin Chatman, Creighton
Johnny Hill, Illinois State
Walt Lemon, Jr., Bradley
Dyricus Simms-Edwards, Bradley
*--indicates team captain


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Natural Selection
You've heard about it, now learn about it! In this BrainPOP movie, Tim and Moby explain the details of natural selection (and with natural selection, it's all in the details)! You'll see how both environmental factors and mutations in an organism's genetic material lead to natural selection doing its thing. You can also discover out how natural selection is related to evolution and what the term "survival of the fittest" means. And, you'll find out how all life on Earth is connected, thanks to natural selection. It's so naturally awesome!
Learn More:What is artificial selection?How do living things respond to changes in their environments? What is an adaptation?
See a Full List of Topics


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Mrs. Flinger: A work in progress
Fixing Mrs. Flinger Feb 20, 2015
I'm currently working on this website. I want to add back the links to blogs I love, some ways to find content easier, and put in archive, at last, some of the ancient articles. Come back to see updates.
Speaking his language Mar 03, 2008
#Life#Parenting Siblings#Pregnancy#got pee sticks?#The Flinger FamilyAfter knowing Mr. Flinger for nearly twenty years now, seven years of those married, six of those as best friends, and 5 years of dating, you'd think I kinda know the guy a bit. You'd think that. And you'd be right. Mostly. For some reason I've been approaching this whole birth control thing completely wrong. I've been approaching it like a women, with logic and emotion. *We* don't want to have children, so *we* need to find a solution that works for *us*. *We* need to get a cost effective/low impact solution. *We* don't need the Mommy (hi) to be an emotional wreck from the hormones of Birth Control Pills (also? I can not be counted on to take them thus making their reliability around 2%) or the IUD*. *We* don't like condoms. *We*... Read more
Randomness Aug 06, 2007
#Parenting Siblings#Baby O#got pee sticks?The BoyChild will not let me set him down. What-so-ever. At all. Nada. Zilch. No-go. W.T.F. This means I have about thirty-two minutes at the end of the day when Mr. Flinger gets here to do bills, clean, make dinner, eat dinner, pee, shower, and workout. Oh! And type! And write thank you cards! And give myself a pedicure because OY. Did I mention Oy? OY. This too shall pass. I know I know. And if I was really obnoxious and deeply troubling I might say something totally gross like, "I just enjoy this time because one day he'll be fighting me off and I'll miss the days of carrying him around in the sling every goddamn minute of the day." Gag. In other news, I took a pregnancy test. YES! That's right! Internet, I made it an entire ELEVEN WEEKS before peeing on... Read more
Celebrate* Sep 18, 2006Read more
Because this is what I'd say if I just met you on the street Aug 17, 2006
#Pregnancy#got pee sticks?#TTCHere is the kind of information you would get from me if you saw me on the street today. "Yea. I'm almost five weeks pregnant. Yea. So it's not going well. Yasee, I peed on another stick today. And, well, it's not darker and I KNOW they say it doesn't matter but it has to, right? Doesn't it make sense if your HGC went up it would get darker? Yea. I thought so. So anyway, I had another blood work lab today because the nurse isn't pleased with my score of 47 on 17 days past ovulation. Oh, we know when I ovulated because I took this ovulation strip. Oh, it's so neat, it'll tell you when your egg is about 48 hours from being released. Crazy, hu? Anyway, so I had to go back in and now they're saying things like... Read more
Because I can convince a nun she's pregnant but not that she's a lesbian May 23, 2006Read more
Times you should NOT have to consult your blog May 08, 2006Read more
You mean I can get a poke any time I wanna? Dec 21, 2005
#Social Clutz Loveable Spaz#got pee sticks?No, it's not the latest porn movie hitting the Internet, it's what my Doc said after I admitted to peeing away hundreds of dollars in pregnancy sticks. After last week's episode, she demanded I take a blood pregnancy test because, let's face it, I was whacked and a week late. Also, regardless of how many fake positive or real negative tests I take, I still believe I'm pregnant. Hell, I can be bleeding like a stuck pig and think I'm pregnant. Trust me. Or don't. Read it for yourself. Anyway, so she calls with the results telling me, upon my answering the phone, "The answer is no." [silence] Me, "Hmm. MmmK." She asks if this is sad news. I think about it. "No," I say hesitating, "no, not really. I mean... Read more


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In Edge of Tomorrow, Tom Cruise's character endures an experience reminiscent of Groundhog Day. He relives his dying day over and over, hoping to eventually gain the skill and smarts to break the loop and conquer his enemies. But the similarities end there. In Edge of Tomorrow, the world is a high-tech yet recognizable future where human soldiers equipped with robotic suits must fight off invading aliens.
Oscar®-winning cinematographer Dion Beebe, ASC, ACS (Chicago, Collateral, Memoirs of a Geisha, Land of the Lost, Green Lantern, Nine, Gangster Squad) had previously worked with director Doug Liman (Swingers, Mr. & Mrs. Smith, Jumpers, The Bourne Identity) on a few commercials, but never on a project of this scale. They worked toward a visual strategy through careful preproduction testing.
"I really find that that's the best way," says Beebe. "Get into a darkened screening room and run the footage, and then measure reactions, talk about what works, and what doesn't. It becomes a more defined way to find what a project requires."
In this case, because the pivotal, repeating battle scenes take place on a beach, the production set up sandpits and tried to add in as many elements as possible – debris, smoke and even pyro effects. Beebe shot the tests on KODAK VISION3 200T Color Negative Film 5213, and brought in DI colorist Peter Doyle, with whom he worked to create a range of options in terms of look. One key phrase Liman used in communicating the tone he wanted was "a world worth saving."
"That meant that we wanted to present a world under siege, but not a bleak, dark, post-apocalyptic landscape," Beebe explains. "It's not overly saturated or cool, and there's some sense of realism. There is a love story element, and we needed to protect for that. We didn't want to come at this with a bleach bypass type of approach, which can be a little harsh on faces. Some of the scenes with Tom and Emily Blunt needed to be a little softer, and of course we would complement that with our lighting choices."
Beebe shot the majority of Edge of Tomorrow on KODAK VISION3 500T Color Negative Film 5219, using some of the 200T as well. The lenses were Panavision anamorphics. The decision to go with 35mm film in the anamorphic format was an easy one.
"There was clear feeling all around that 35mm was the right approach here," says Beebe. "This film has a slight parallel with the storming of the beaches in Normandy, and that might have played a part, because all the images we have from Normandy and World War II are film references, either still or motion. I think that did resonate for us. Also, we didn't want it to feel too glossy or removed – we wanted the texture of film, and a very visceral, immediate and subjective experience."
Logistical considerations also factored into the decision. Sometimes as many as six cameras were shooting on the beach amidst the pyrotechnics. "In setting up the action, you can cut your operators loose a little bit," says Beebe. "You're not running cable or signal to a complex switching system with six high def monitors. You can pay the images less heed, in a way, and really work towards what's in front of you – the action that you are there to cover."
Given the repetitious nature of the story, maintaining continuity and consistent lighting was a constant concern. Shooting on the backlot at Leavesden Studios in the U.K. provided a degree of control.
The interior of a helicopter drop-ship built by production designer Oliver Scholl also provided Beebe with a unique lighting situation. Outfitted in their heavy robotic suits, the actors hang in rows inside the narrow cabin. When the time comes, the floor opens and they are dropped earthward on cables.
"Doug wanted a kind of sardine can, a dehumanized environment," says Beebe. "He wanted these people reduced to weapons, basically, that are jammed into this vehicle that is meant to deposit them."
The structure was built 20 feet in the air so it could be mounted on a gimbal to be pivoted, rotated and shaken. Getting the actors in and out, one by one, was a tricky proposition, and they could only stay in for about 30 minutes at a time. There were safety considerations, and the suits were extremely uncomfortable when rigged into the ship. Beebe's approach was to create an almost entirely practical lighting environment in the interior that could be operated via his lighting desk, in part because once the actors were in place, it was nearly impossible to access the tight space with lights. This practical lighting was accomplished using a lot of LED ribbon and fluorescent tubes, among other tools.
A rig made up of moveable Vari-Lites was constructed around the outside of the drop-ship set, aimed through windows and other gaps and programmed to simulate a sense of motion and to mimic sunlight passing through the windows. At one point the ship is hit by enemy fire, and a circular chase effect tells the audience the ship is in a desperate spiral.
All the action comes together in the widescreen, 2.40:1 anamorphic aspect ratio. "We chose anamorphic in order to encompass a vast landscape for the story," says Beebe. "We wanted a really large canvas for this film. It goes back to this idea of 'a world worth saving.' We wanted a reminder that the stakes are high, that the world could be lost, and all this would be lost with it."
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The Heir Apparent: Largo Winch
Action/Adventure, Suspense/Thriller
When billionaire financier Nerio Winch and head of the W Group is murdered, his second in command must locate his only heir - a heretofore unknown adopted son, Largo. But first the heir - a twentysomething adventurer - must overcome an onslaught of drug traffickers, assassins, corporate raiders and double-dealing insiders to fulfill his destiny in this twisty, fast-paced corporate thriller.
Cast: Kristin Scott Thomas, Miki Manojlovic, Gilbert Melki, Mélanie Thierry, Tomer Sisley
Produced by:
Directed by: Jérôme Salle
Written by: Julien Rappeneau, Philippe Francq
Running time: 1hr 48min
Opens: Nov 18, 2011 NY/LA
|Theaters for Today
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TMC278-TiDP6-C154: Evaluation of the Possible Influence of Omeprazole Intake - and the pH Increase in the Stomach Triggered by Omeprazole Intake - on the Blood Levels of TMC278 in Healthy Volunteers
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- How to Read a Study Record
The purpose of this study is to investigate the extent by which intake of 20 mg once daily (q.d.) omeprazole influences the levels of TMC278 in the blood after intake of 25 mg q.d.. This study also investigates - in case levels of TMC278 are reduced when co-administered with omeprazole - whether a double dose of TMC278 (50 mg q.d.) or a separation of intake of both drugs by 12 hours may circumvent a decrease of TMC278 levels in the blood below the clinical effective concentration. Omeprazole is prescribed to reduce the production of gastric acid. Since TMC278 requires gastric acid to be properly dissolved and taken up in the blood circulation, intake of omeprazole has an influence on the levels of TMC278 in the blood circulation. This effect has been revealed in a previously conducted clinical trial, using the combination of 150 mg TMC278 q.d. and 20 mg q.d. omeprazole. The currently proposed study will also further explore the relationship between the levels of TMC278 in the blood at several time points and the acidity of the stomach. Also the short-term safety and tolerability of co-administration of omeprazole 20 mg q.d. and TMC278 25 mg q.d. will be assessed.
HIV Infections
Drug: TMC278; Omeprazole
Phase 1
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Phase I, Open Label, Randomized, 4-way Crossover Trial to Evaluate the Pharmacokinetics of TMC278 25mg and 50mg in the Presence of Omeprazole 20mg q.d., in Healthy Subjects
- Plasma levels of TMC278 assessed after co-administration of 20mg q.d. omeprazole taken either in the morning (1.5 h before TMC278) or in the evening (12 h before TMC278); assess 24h intragastric pH at days of intake of TMC278 [ Time Frame: Plasma levels: Treatment A, B, C and D: Day1 (at 11 time points), Day2, 3, 4, 6 and 8 (all at 1 time point). Intragastric pH: Treatment A, B, C and D at Day1 (=day of intake TMC278). ] [ Designated as safety issue: No ]
- To evaluate the short-term safety and tolerability of co-administration of omeprazole with a single 25mg and 50mg dose of TMC278 [ Time Frame: 13 weeks (this includes a treatment, washout and follow up period and is excluding screening period of maximum 21 days before first medication intake) ] [ Designated as safety issue: No ]
|Study Start Date:
|January 2010
|Study Completion Date:
|April 2010
|Primary Completion Date:
|April 2010 (Final data collection date for primary outcome measure)
This is an open label study, which means that all parties including the study doctor, the healthy volunteer and the sponsor plus his designees will know at all times which treatment the volunteer is in. This is a 4-way cross over trial, which means that every volunteer will be sequentially subjected to 4 different treatments.There are 4 treatment sequences defined: ABCD, BDAC, CADB and DCBA. Treatment sessions are organized in such a way that between successive intakes of TMC278 a period of 14 days is respected. Treatment A is the reference, showing the levels of TMC278 in blood without any intake of omeprazole. These data points will be compared with blood levels of TMC278 when TMC278 is being administered 1.5 hours after intake of omeprazole (Treatment B) or with blood levels of TMC278 when being administered 12 hours after intake of omeprazole (Treatment C). Treatment B will be the comparator of Treatment D, in order to reveal whether doubling the dose of TMC278 (50 mg q.d. used in Treatment D) can circumvent the reduction of TMC278 levels when being co-administered with omeprazole, if applicable. In each session, an extensive investigation of the levels of TMC278 in the blood circulation is planned. Levels of TMC278 will be assessed at 16 different time points, i.e. before administration of TMC278, 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 16, 24, 48, 72, 120 and 168 hours after intake of TMC278. During all treatments, the acidity in the stomach (called intragastric pH) will be monitored during a 24-hour period on the day of TMC278 intake. Standard Safety assessments (blood biochemistry and haematology, urine analysis, ECG, pulse rate and blood pressure) will be performed on Day1, 2 and 8 in Treatment A and on Day-5, 1, 2, 8 in Treatment B, C and D. Treatment A: 25mg TMC278 in the morning of Day1; Treatment B: 25mg TMC278 in the morning of Day1 and 20mg omeprazole in the morning from Day-5 through Day2 (7 days in total); Treatment C: same as treatment B, but omeprazole is taken in the evening; Treatment D: same as treatment B, but 50mg omeprazole is taken instead of 25mg. All intakes are oral. In Treatment B, C and D, the intake of omeprazole is witnessed by site staff on Days -5, -3, -2 and -1
|Ages Eligible for Study:
|18 Years to 55 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Smoking no more than 10 cigarettes, or 2 cigars, or 2 pipes per day (or non-smoking) for at least 3 months prior to selection
- Weight as defined by a Body Mass Index (BMI, weight in kg divided by the square of height in meters) of 18.0 to 30.0 kg/m2, extremes included
- Informed Consent Form (ICF) signed voluntarily
- Able to comply with protocol requirements
- Healthy on the basis of a pretrial physical examination, medical history, the results of blood biochemistry and hematology tests, a urinalysis, vital signs, and a 12-lead electrocardiogram (ECG)
Exclusion Criteria:
- No positive testing for HIV-1 or -2
- females, except if menopausal for at least 2 years, or with total hysterectomy or bilateral tubal ligation (without repair surgery)
- No infection of Hepatitis A, B or C
- No currently active gastrointestinal, cardiovascular, neurologic, psychiatric, metabolic, renal, hepatic, respiratory, inflammatory or infectious disease
- No history of clinically relevant heart rhythm disturbances
- No positive urine drug testing
Please refer to this study by its ClinicalTrials.gov identifier: NCT01001247
|Study Director:
|Tibotec Pharmaceuticals Clinical Trial
|Tibotec Pharmaceutical Limited
No publications provided
|Responsible Party:
|Compound Development Team Leader, Tibotec Pharmaceuticals, Ireland
|ClinicalTrials.gov Identifier:
|NCT01001247 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 23, 2009
|Last Updated:
|July 8, 2010
|Health Authority:
|Ireland: Irish Agriculture and Food Development Authority
Keywords provided by Tibotec Pharmaceuticals, Ireland:
Healthy volunteers
proton pump inhibitor
Additional relevant MeSH terms:
Anti-Ulcer Agents
Enzyme Inhibitors
Gastrointestinal Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Proton Pump Inhibitors
Therapeutic Uses
ClinicalTrials.gov processed this record on October 08, 2015


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Saturday, May 12, 2007
May 12, 2007
In the first day of the Atlantic Sun Conference Track and Field Championships Friday Todd Garrett and Susan Worden led the way for Lipscomb.
Garrett finished in a three-way tie for third in the men's pole vault with a 4.45-meter effort.
Josh Hogan finished 12th in the men's long jump with a 4.89-meter attempt.
Susan Worden finished fifth in the women's 10,000 meters run with a time of 39:14.37
Hannah Joiner was fifth in a preliminary heat of the 100 meters hurdles with a time of 16.66.
Danielle Graham finished 10th in the women's long jump with a 4.44=meter effort.
Kyle Mullen was ninth in the women's discus throw with a 24.92 meter attempt.
The A-Sun championships continue Saturday at ETSU in Johnson City, Tenn.
|Copyright ©2015 Lipscomb University Athletics. All Rights Reserved.