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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
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MASSENA A Colton man has failed to convince a judge that his free-speech rights allowed him to protest inside the lobby of the publicly owned Massena Memorial Hospital last year.
Donald L. Hassig was found guilty of trespass following a trial Friday in Village Court in connection with the Oct. 24 incident. He was charged when he refused a request by the hospitals senior director of ancillary services, Mark P. Brouillette, to move his protest to the sidewalk.
Under questioning from St. Lawrence County Assistant District Attorney Andrew T. Botts, Mr. Brouillette testified that he had received a call or a visit about 10 a.m. that day alerting him to a disturbance. He said he found Mr. Hassig in the lobby handing out pamphlets to patients and staff.
The hospital administrator said he asked Mr. Hassig to take his protest outside but he refused, saying that there were no people outside and that he did not want to be exposed to vehicle exhaust. It was a disturbance to staff and patients making for an unsafe and unsecure environment, a violation of polices and procedures, Mr. Brouillette said.
Mr. Hassig, who represented himself at the bench trial before acting Village Justice James M. Crandall, questioned the assertion he was causing a disturbance during his cross-examination of Mr. Brouillette.
He asked Mr. Brouillette whether his behavior had included loud noise or physical altercations in the hospital.
I did not receive reports of loud noise inside the hospital, and I did not witness it myself, Mr. Brouillette replied to Mr. Hassig. Basically, people were unable to enter the hospital without going past you when you were pushing literature and making comments.
Mr. Hassig again questioned whether he was a physical obstacle to people entering the hospital, contending he was standing back from the doors near the information desk asking people if they were interested in cancer and chemicals.
It is a violation of policy to have someone in the hospital without a purpose, an individual with their own crusade going on. We cannot have people on the premises that dont belong there, Mr. Brouillette said.
Mr. Hassig said in his opening argument that he chose to speak at Massena Memorial because it is a public facility and had a number of patients who were exposed to dioxins when they were in Vietnam.
Mr. Crandall urged Mr. Hassig to focus his arguments on the trespassing violation, noting he was not charged with disorderly conduct.
The vital question here is whether your endeavor can or cannot be carried out in a public hospital after you have been told to leave by the person in charge, Mr. Crandall said. You are saying your First Amendment rights supersede New York state penal law.
Mr. Crandall postponed sentencing. Mr. Hassig said he plans to appeal.
The Massena Memorial Hospital is owned by the town of Massena. It is a public building, he said after the verdict. The Constitution guarantees me free speech there.
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Operators at Oyster Creek Generating Station reduced power on the unit overnight to allow plant teams access to make repairs to a six-inch pipe that penetrates the turbine building. The station is currently operating at about 50 percent power.
FORKED RIVER, NJ - Operators at Oyster Creek Generating Station reduced power on the unit overnight to allow plant teams access to make repairs to a six-inch pipe that penetrates the turbine building. The station is currently operating at about 50 percent power.
After station operators identified a leak inside the turbine building late Monday, technicians proactively began excavating the area outside the turbine building to check for water outside the building as part of the station's environmental monitoring program.
Station operators know most of the water from the pipe, which passes through a 4-foot-thick concrete wall, is confined to the turbine building. Samples taken from the excavation returned elevated concentrations of tritium, indicating some of the water may have made its way into the soil immediately adjacent to the structure. Plant teams are taking immediate actions to stop the leak.
"While this is not a public or employee safety issue, we identified this leaking pipe and are immediately taking steps to make the necessary pipe repairs," said Mike Massaro, Site Vice President of Oyster Creek Station. "We quickly contacted federal and state regulators with our findings and will continue to keep them and the greater Oyster Creek community informed as we repair the pipe."
Water samples taken daily from the plant's discharge canal continue to show no detectable levels of tritium. Samples taken from the excavation contain tritium levels up to 10 million picocuries per liter of water. A picocurie is one trillionth of a curie. The excavation is near the area where plant teams found and stopped two small leaks in April. At that time, station operators replaced an eight-inch pipe and a ten-inch pipe, and they continue to inspect pipes in the area as part of the site's aging management program.
Massaro said station and corporate engineering experts are currently evaluating the best environmental course in rerouting the pipe above ground, or to construct a vault around the pipe.
Tritium is a weak, naturally occurring radiation emitter that is used commercially to make luminous dials and instruments, as a source of light for exit and safety signs, as a tracer for biochemical research and in ground water transport measurements, among other uses. It is produced in higher
than natural concentrations in commercial nuclear reactors. A tritium fact sheet from the U.S. EPA can be downloaded at http://www.epa.gov/radiation/radionuclides/tritium.html
Oyster Creek is about 60 miles east of Philadelphia in Ocean County, New Jersey. The plant produces 636 net megawatts of electricity at full power, enough electricity to supply 600,000 typical homes, the equivalent to all homes in Monmouth and Ocean counties combined.
Exelon Corporation is one of the nation's largest electric utilities with approximately $17 billion in annual revenues. The company has one of the industry's largest portfolios of electricity generation capacity, with a nationwide reach and strong positions in the Midwest and Mid-Atlantic. Exelon distributes electricity to approximately 5.4 million customers in northern Illinois and southeastern Pennsylvania and natural gas to approximately 486,000 customers in the Philadelphia area. Exelon is headquartered in Chicago and trades on the NYSE under the ticker EXC.

subset: commoncrawl


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HI all
I am a new to linux and scripting...
so need your help in making a script...
which will
1) check for todays date & time
2) compare with specified date & time (given in script)
3) if it matches then deletes all the content of the folder
any help will be appreciated
Last edited by bikram; 01-10-2007 at 10:46 AM.
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#32 - Tennyson Dodd
|2010-11 Baseball
RS So.
Murfreesboro, Tenn. (Oakland HS)
2010 (Sophomore): Medical redshirt ... Member of Atlantic Sun All-Academic Team.
2009 (Freshman): Two or more hits in a game 14 times (11 with two hits, two with three, one with four). Individual high four hits in a game vs. Campbell (5/8). …Tied for third on the team with eight multiple RBI games (five with two RBI, two with three and one with seven. …His seven RBI vs. Campbell (5/8) was the team high for the season. …Tied for the longest hitting streak on the team with hits in 13 straight games from 4/21 to 5/15 with six multiple-hit games during the streak. …Set a team high for total bases in a game with 10 vs. Campbell (5/8). …Tied for team lead in home runs in a game with two vs. Campbell (5/8). …Designated hitter 38 times and first baseman nine times. …Third on team in runs batted in (32). …Tied for third on team in doubles (10). …Fourth on team in total bases (73). …Fifth on team in slugging percentage (.427).
High School: All-District 7-AAA (2008), Tennessee Sportswriters Association All-State (2008), Louisville Slugger Preseason All--American (2008). ...District 7-AAA MVP (2007), Region 4-AAA MVP (2007), Tennessean All-Midstate Team (2007), Tennesse Sportswriters Association All-State (2007), Louisville Slugger All-American (2007), Junior Sunbelt Team for Tennessee (2007). ...Also played basketball as a freshman. ...President of high school Fellowship of Christian Athletes club. ...Key Club member.
Personal: Parents are Sonya and Chip Dodd. ...One brother, William. ...Also recruited by Middle Tennessee State, Belmont, Western Kentucky, University of Tennessee and Vanderbilt.
|Copyright ©2015 Lipscomb University Athletics. All Rights Reserved.


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The Acer beTouch is a phone that has garnered a lot of attention from a number of different websites in recent days. Although the phone does not boast the most high-powered features in the smart phone industry, it's low price and simplicity of its features have made the device highly attractive to users who want all the functionality of a smart device without having to deal with the high prices, large size of the phones and complicated features.
The Acer beTouch will feature a 600 MHz processor that is capable of running most of the apps that will be available for the phone through the Android store. It will also feature a 2.8 inch QVGA touchscreen, which is much smaller than most android smart phones, along with a 3.2 megapixel camera, Bluetooth 2.1 capabilities, Wifi enabled and HSDPA connections.
This unlocked cell phone will reportedly start at just $264, significantly cheaper than most other smart phones. The Acer beTouch is a phone that is ideal for individuals who are just making the leap into smart devices, or for individuals that are looking for a smaller device. The phone was purposely designed for individuals on a budget who simply can not live without a smart device.
aThere have been no announcements as to whether or not the phone will be available in United States. Most reports have stated that the phone is nearing completion and is nearly ready for a release in the United States, so much so that experts have predicted that Acer could make an announcement regarding the release date of the phone over the course of the next few days. the Acer beTouch E130 was shown off at Computex 2010, where it was announced that the phone will run on the Android Froyo platform. It will be interesting to see how well the phone is received by the budgeting segment of the smart device market.
PureMobile carries a wide range of unlocked cell phones and Android phones such as Sony Ericsson Xperia X10i Unlocked, LG Eve GW 620, HTC Desire etc…


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FRIDAY NIGHT: Decreasing clouds and chilly. Low: 43. Winds: Northeast 5-10.
SATURDAY: Sunny. High: 70. Winds: Light Southwest.
SUNDAY: Sunny ...
Carlinville Orchard Ready for Peach Crop
As many farmers know, their crop relies on Mother Nature. Although last year's drought conditions didn't make it easy on peach farmers, this year's weather couldn't be better.
"The weather this year, every year is different, every year is different," Jeff Broom of Broom Orchard said. "I have been in it 30 years and there are no years the same."
With last year's drought and this year's overabundance of rain combined with heavy winds, it's rough for a delicate crop such as a peach.
"Our biggest nightmare would be hail," Broom said. "As the fruit hangs out there, and if it gets hailed on it's blemished and just doesn't heal."
Since there has been no significant hail this season, the saying "bruised like a peach" doesn't affect the peaches at Broom Orchard, which is why the peach season will be booming during the next couple of weeks.
"The bulk of our crop is going to come on the third and fourth week of July," Brook said. "That's when we'll get started. It's a Red Haven. It's the old standard peach which is the measuring stick for all other varieties."
With nearly 30 acres of peaches coming in during different times of the summer, employees at Broom Orchard are already busy picking and sorting.
"Peaches come from the orchard, they are picked tree ripened," employee Jennifer Heller said. "We have to go through them to make sure there are no bruised ones and any that are not top quality. And we take those out and box up the best peaches."
Each peach tree produces about four bushels of peaches, which is why picking only the best peaches all depends on timing.
"There's all different kinds of variety of peaches and ripen at different times," Broom said. "I pick the ones that I like that ripen the best and they ripen one after the other."
The different varieties of peaches at Broom Orchard will be available at various times throughout the summer.
Right now, they have Summer Serenade peaches and in a few weeks they will have Garnet Beauty peaches and Red Haven peaches.
Click here for the Broom Orchard website.


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Royal Solaris Los Cabos offers a beautiful oceanfront setting to celebrate this magical day and enjoy an unforgettable honeymoon.
Let us give you our experience and the highest levels of quality and service to make your celebration a unique experience.
Below is a brief description of our wedding packages and honeymoon.


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Unlocked Samsung released the (Gravity 2) in a response to all of those that wanted a great messaging phone. It is a newer model of the Gravity from Samsung and is not only a candy bar style phone, but also has the slide out keyboard. The great pumpkin color and the slim design make it easy to handle. The phone is 4.5 inches x 2.5 inches and is .60 thick. It makes it very easy to carry the phone and to hold. The screen provides 2.3 inches of viewing and has a 240x320 mega pixel screen resolution.
The Samsung Gravity 2 is great for those looking for a cellular phone with enhanced messaging features, and all of the phone functions to make life easier. The front of the phone has three larger keys for sending receiving and messaging. The outer ring of the ok button will give you the ability to navigate your social media contacts as well as your call logs. There is a lot of room in between the keys and they are raised in order to be able to access them much easier. There is a data entry book that will allow you to store over 1000 entries and giving you the ability to store all kinds of great information about your family and friends. The phone will let you do predictive text, which makes messaging just that much simpler.
The Samsung Unlocked ( Gravity 2) gadget uses the 3G network and is Bluetooth ready. It comes with A-GPS application with term by turn directions. It has all of the wonderful media features, and streaming videos is quite simple. The phone has a two megapixel camera with zoom and all people shot features. It also has an MP3 player, which you will feel to download and store all of your favorite music and you can even choose your favorite song as background music for your phone. The battery life gives you 5.5 hours of talk time and over 12 days of additional standby time. This phone is in an affordable price range and is a great social media and messaging mobile phone device.


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Enter your zip code for product availability and pickup options at your nearest store or select a store by state.
The Store 'n Slide 5-Section combines the ingenious mechanism of our Handled Tool Holders with a sliding rack to put often-wasted narrow spaces to work storing and organizing handled tools like mops, brooms, dusters, and squeegees. It's ideal between appliances like a refrigerator or washing machine and a wall, in a small closet or the cramped space of a utility area. The sliding rack can be installed to slide out either to the left or right, and is easily wall-mounted using the template and hardware included. The 5-Section Handled Tool Holder grips handles firmly in place using non-skid rubber contact points and the tension created by gravity. Just stick the handle into the slot and release; the weight of the object will hold it in place. When your housework is complete, push the Store 'n Slide back out of the way and out of sight. Click on the image to see this feature.
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Buying basics
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The Historic Wholesale Market Of Smithfield
A notice gives details of cardboard recycling in front of a butchers'... News PhotoAgriculture,Butcher's Shop,Cardboard,Close-Up,England,Finance,Giving,Horizontal,Human Interest,London - England,Merchandise,Recycling,Smithfield Market,UKPhotographer Oli ScarffCollection: Getty Images News 2013 Getty ImagesLONDON, ENGLAND - MARCH 14: A notice gives details of cardboard recycling in front of a butchers' stall in Smithfield Market on March 14, 2013 in London, England. Smithfield Market, which is officially named the 'London Central Markets', has been the site of a livestock market since the Twelfth Century. Located in the City of London, the market's Victorian buildings were designed by Sir Horace Jones, the City Architect, and were completed in the 1860s. Developers have recently proposed a 160 million GBP refurbishment of the derelict western end of Smithfield Market into an artisan food centre known as 'Smithfield Quarter'. (Photo by Oli Scarff/Getty Images)


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A Study Exploring Two Treatment Strategies in Patients With Atrial Fibrillation Who Undergo Catheter Ablation Therapy (VENTURE-AF)
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The purpose of this exploratory study is to evaluate the safety of rivaroxaban and uninterrupted vitamin K antagonist (VKA) in adult participants with non-valvular atrial fibrillation (NVAF) who undergo catheter ablation as measured by post-procedure major bleeding events.
Atrial Fibrillation
Drug: rivaroxaban
Drug: uninterrupted vitamin K antagonist (VKA)
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Randomized, Open-label, Active-controlled Multi-center Study to Assess Safety of Uninterrupted Rivaroxaban vs. Usual Care in Subjects Undergoing Catheter Ablation Therapy for Atrial Fibrillation
- Incidence of post-procedure major bleeding events [ Time Frame: During the first 30 ± 5 days after the catheter ablation procedure ] [ Designated as safety issue: Yes ]
- Event rate of the composite endpoint of myocardial infarction (MI), ischemic stroke, non-Central Nervous System (non-CNS) systemic embolism and vascular death [ Time Frame: During the 30 ± 5 days after the catheter ablation procedure ] [ Designated as safety issue: Yes ]
- Event rate of myocardial infarction (MI) [ Time Frame: During the 30 ± 5 days after the catheter ablation procedure ] [ Designated as safety issue: Yes ]
- Event rate of ischemic stroke [ Time Frame: During the 30 ± 5 days after the catheter ablation procedure ] [ Designated as safety issue: Yes ]
- Event rate of non-Central Nervous System (non-CNS) systemic embolism [ Time Frame: During the 30 ± 5 days after the catheter ablation procedure ] [ Designated as safety issue: Yes ]
- Event rate of vascular death [ Time Frame: During the 30 ± 5 days after the catheter ablation procedure ] [ Designated as safety issue: Yes ]
|Study Start Date:
|February 2013
|Study Completion Date:
|October 2014
|Primary Completion Date:
|October 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: rivaroxaban
rivaroxaban 20 mg orally, once-daily, administered preferably with the evening meal
Drug: rivaroxaban
rivaroxaban 20 mg orally, once-daily, administered preferably with the evening meal
Experimental: vitamin K antagonist (VKA)
dose-adjusted vitamin K antagonist (VKA) to achieve a recommended International Normalized Ratio (INR) of 2.0 to 3.0
Drug: uninterrupted vitamin K antagonist (VKA)
dose-adjusted vitamin K antagonist (VKA) to achieve a recommended International Normalized Ratio (INR) of 2.0 to 3.0
Detailed Description:
This is a randomized (participants are assigned to intervention groups by chance), open-label (both physicians and participants know the identity of the assigned treatment), active-controlled, multi-center safety study of rivaroxaban or VKA before and after a catheter ablation procedure. This study requires collaboration with medical institutions that provide access to electrophysiologists who normally perform the catheter ablation procedure. In this study, NVAF is to be defined as the presence of AF in a person who does not have a prosthetic heart valve (annuloplasty with or without prosthetic ring, commissurotomy and/or valvuloplasty are permitted) and who does not have hemodynamically significant mitral valve stenosis. Approximately 250 eligible participants, age 18 years or older, with a history of paroxysmal, persistent, or long standing persistent NVAF who are scheduled to undergo an elective catheter ablation procedure will be randomized in a 1:1 ratio to receive either rivaroxaban 20 mg orally, once-daily, administered preferably with the evening meal or VKA (adjusted to achieve a recommended International Normalized Ratio of 2.0 to 3.0).
The study will consist of a screening period, a pre-procedure period, procedure period and post-procedure period. The screening period will begin up to 2 weeks prior to randomization. Participants will be randomized at the beginning of the pre-procedure period. During this period, participants will be recommended to receive their assigned treatment for at least 4 weeks (maximum of 5 weeks) before the catheter ablation procedure. For participants with the sufficient anticoagulation, documented for the 3 weeks prior to randomization, and for participants with a transesophageal echocardiogram (TEE) or intracardiac echocardiography (ICE), the length of the pre-procedure period may be reduced down to 1-7 days and must include any transition from the previous anticoagulation therapy to randomized study drug.
After the catheter ablation procedure, participants will receive their post-procedure dose of study drug through a minimum of 30 + - 5 days. In addition to scheduled visits and telephone calls the study may also include additional phone calls and visits by the participant to the site when dose adjustment is required for usual care.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Be scheduled for a catheter ablation procedure for non-valvular atrial fibrillation (NVAF);
- Have a documented history of paroxysmal (lasting <1 week) or persistent (lasting >1 week and <1 year or requiring pharmacological or electrical cardioversion), or long standing persistent (>=1 year) NVAF;
- Be suitable for anticoagulant therapy and catheter ablation as per the judgment of the investigator;
- Women must be postmenopausal before entry or practicing a highly effective method of birth control when heterosexually active;
- Women of childbearing potential must have a negative serum pregnancy test at screening;
- Be willing and able to adhere to the prohibitions and restrictions specified in the study protocol;
- Have a life expectancy of at least 6 months
Exclusion Criteria:
- Has a history of a prior stroke, transient ischemic attack (TIA) or non-convulsive status epilepticus within 6 months of the screening visit;
- Has a history of a major bleeding or thromboembolic event within the 12 months immediately preceding the catheter ablation procedure;
- Has had major surgery (requiring general anesthesia), within 6 months before screening or planned surgery during the time the subject is expected to participate in the study;
- Has NVAF due to electrolyte imbalance, hyperthyroidism, or other reversible or noncardiac cause of NVAF;
- Has any condition that, in the opinion of the investigator, would make participation not be in the best interest (eg, compromise the well-being) of the participant or that could prevent, limit, or confound the protocol-specified assessments
Please refer to this study by its ClinicalTrials.gov identifier: NCT01729871
Hide Study Locations
|United States, California
|Beverly Hills, California, United States
|Los Angeles, California, United States
|Sacramento, California, United States
|San Francisco, California, United States
|United States, Florida
|Jacksonville, Florida, United States
|United States, Illinois
|Maywood, Illinois, United States
|United States, Kansas
|Westwood, Kansas, United States
|United States, Massachusetts
|Boston, Massachusetts, United States
|United States, Minnesota
|St Louis Park, Minnesota, United States
|United States, New Jersey
|Ridgewood, New Jersey, United States
|United States, New York
|Flushing, New York, United States
|United States, North Carolina
|Durham, North Carolina, United States
|United States, Ohio
|Columbus, Ohio, United States
|United States, Oregon
|Portland, Oregon, United States
|United States, Pennsylvania
|Erie, Pennsylvania, United States
|Hershey, Pennsylvania, United States
|Philadelphia, Pennsylvania, United States
|United States, Tennessee
|Nashville, Tennessee, United States
|United States, Texas
|Austin, Texas, United States
|Dallas, Texas, United States
|Tyler, Texas, United States
|United States, Virginia
|Charlottesville, Virginia, United States
|United States, Washington
|Seattle, Washington, United States
|Tacoma, Washington, United States
|Aalst, Belgium
|Antwerpen, Belgium
|Brugge, Belgium
|Genk, Belgium
|Hasselt, Belgium
|Brest Cedex 2, France
|Montpellier, France
|Pessac Cedex, France
|Toulouse Cedex 9 N/A, France
|Vandoeuvre Les Nancy, France
|Bad Krozingen, Germany
|Bad Nauheim, Germany
|Berlin, Germany
|Dresden, Germany
|Jena, Germany
|Mönchengladbach, Germany
|Neuwied, Germany
|United Kingdom
|Bournemouth, United Kingdom
|Cottingham, United Kingdom
|London, United Kingdom
|Study Director:
|Janssen Scientific Affairs, LLC Clinical Trial
|Janssen Scientific Affairs, LLC
No publications provided by Janssen Scientific Affairs, LLC
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Janssen Scientific Affairs, LLC
|ClinicalTrials.gov Identifier:
|NCT01729871 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 23, 2012
|Last Updated:
|November 5, 2014
|Health Authority:
|United States: Institutional Review Board
United States: Food and Drug Administration
Germany: Ethics Commission
Great Britain: Medicines and Healthcare Products Regulatory Agency
Germany: Federal Institute for Drugs and Medical Devices
Keywords provided by Janssen Scientific Affairs, LLC:
Atrial Fibrillation
Irregular heart beat
Catheter Ablation
Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Cardiovascular Diseases
Heart Diseases
Pathologic Processes
Vitamin K
Antifibrinolytic Agents
Fibrin Modulating Agents
Growth Substances
Hematologic Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses
ClinicalTrials.gov processed this record on October 13, 2015


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The Gastroenterology Division at Hartford Hospital gives the region's physicians and their patients fast, convenient access to superlative GI care.
From routine screenings and common tests to advanced procedures and complex cases, Hartford Hospital's Gastroenterology Division offers the expert diagnostic and treatment capabilities that referring physicians demand, combined with the compassionate care every patient deserves.
Exceptional, Experienced Practitioners
Rigorous, continuous learning ensures that all members of Hartford Hospital's GI Medical Staff are current with emerging knowledge in their field. Our gastroenterology nurses and associates are highly qualified professionals dedicated to staying abreast of developments in their field and using best practices to provide excellent patient care. Many have earned advanced certification from the national Society of Gastroenterology Nurses and Associates. (
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The Most Advanced Technology
Hartford Hospital's long-standing commitment to technological innovation means that the Gastroenterology Division has the most advanced medical technology available anywhere. We use the latest endoscopic instruments with high-definition images and narrow-band image capability for improved detection and diagnosis of GI disorders. Our sophisticated digital fluoroscopy and radiology equipment delivers the highest-quality images, with the lowest radiation exposure. And new impedance and manometry equipment means vastly improved diagnosis and treatment for patients with reflux and atypical chest pain.
Immediate Access to a Full Range of Specialists
Once diagnosed, patients of Hartford Hospital's Gastroenterology Division can be readily linked to Hartford Hospital specialists who have the precise experience and expertise to treat their illness. Even patients with rare or complex conditions can obtain the expert care they need without having to travel long distances, thanks to Hartford Hospital's full complement of specialists.
Connecticut's Only IDB Center
Inflammatory Bowel Disease
Center at Hartford Hospital is the only center in the state focused intensively on this challenging and complex disorder. Another unique feature is the monthly IBD conference, where an expert, interdisciplinary team reviews complicated cases, discusses options and recommends treatment plans.
Prompt Appointments and Fast Reporting
The large number of physicians on the Gastroenterology Medical Staff means that patients referred to the division can be seen promptly. Referring physicians receive timely reports on their patients' visits and immediate telephone calls when findings are significant.
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Compassionate Care
Known or suspected illness places significant strain on patients. Recognizing this, our physicians, clinicians and administrative staff are dedicated to treating each patient with sensitivity and respect.
Patient comfort and privacy are among our most important goals.
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Marry Us in Michigan72 Reviews
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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
POTSDAM The veteran academic tapped to lead SUNY Potsdam during its search for a new president is an economist by training with a self-professed eye for the bottom line.
Dennis L. Hefner said Thursday that he embraces economies of scale and more shared services among SUNY institutions. But he also will look to continue SUNY Potsdams tradition of excellence and work to increase enrollment during his upcoming tenure as interim president of what he called a public ivy university.
One of my goals is to lessen the concerns about shared services, Mr.Hefner, 67, said during a meeting with reporters.
Both SUNY Potsdam and SUNY Canton are seeking new presidents, which has resulted in heightened sensitivities about how increased integration between the two campuses could affect students and employees.
I believe in shared services. Where you can reduce costs or improve the quality of services by having two campuses come together or share what theyre doing, that is the right thing to do, Mr. Hefner said.
But Mr. Hefner also said he believes that the north country needs the distinctive academic offerings provided in Canton and Potsdam, each of which works to bring students, families and money to the region.
Mr. Hefner was chosen by the SUNY Board of Trustees last month to serve as interim replacement for John F. Schwaller, who will resign in July after more than seven years in the post. His appointment, at a $225,000 salary, takes effect June 1.
At SUNY Canton, meanwhile, former provost Jeremy D. Brown has been named acting president to replace Carli S. Schiffner, who has served as SUNY Cantons interim president since longtime President Joseph L. Kennedy stepped down last year. He will receive a $185,000 salary and a $4,000 monthly housing allowance, also starting June 1.
Prior to his own retirement this year, Mr. Hefner spent 16 years as president of SUNY Fredonia in Western New York, a school SUNY Chancellor Nancy L. Zimpher described as one of Potsdams peer campuses within our system.
He said he took a full week to consider the offer before accepting.
I said, you know, I think I could probably help, he said.
Mr. Hefner said he hopes to bring lessons learned during his tenure in Fredonia to his time in the north country.
Among those lessons are the benefits to be derived from shared services.
Mr. Hefner said 15 different shared-service agreements were implemented during his presidency at SUNY Fredonia, most involving six or more colleges and all still in operation. Among the most recent, he said, was a pact to share print services among several Western New York colleges, with much of the work being done at Alfred State.
Mr. Hefners tenure at SUNY Fredonia also was marked by enrollment growth of 25 percent. That wasnt merely a factor of natural growth, he said, but it wasnt just me. It was a campus-wide effort.
He credits enhanced academic offerings that focused on the institutions strengths, such as a media arts program, as well as a four-year guarantee under which students have access to all courses needed to graduate within four years.
Mr. Hefner also hopes to see increased enrollment during his time at SUNY Potsdams helm, though he acknowledges that his time there will be limited at least a year, maybe a little longer.
Under SUNY rules, interim presidents cannot be considered for the permanent presidency at the campus where they are serving, but an acting president can continue as a permanent hire.
I wont be here for three or four years, he said.
Currently living in North Carolina, Mr. Hefner has three grandchildren in Texas and a passion for traveling the world with his wife, Jan. He has not decided where he will live during the upcoming appointment, but said it wont be the SUNY Potsdam presidents house, which he said will be home to his permanent replacement.
The colleges await permission from Ms. Zimpher to begin the search for their permanent presidents, a process that SUNY Potsdam officials said could take from six to eight months.
Mr. Hefner is scheduled to meet with the SUNY Potsdam College Council during a special meeting at 10 a.m. today in the Raymond Hall seventh floor boardroom. The meeting is open to the public.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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|Preview Material
|Table of Contents
|Supplementary Material
Translations of Mathematical Monographs
Iwanami Series in Modern Mathematics
2013; 200 pp; softcover
Volume: 243
List Price: US$49
Member Price: US$39.20
Order Code: MMONO/243
This item is also sold as part of the following set: MMONO/243/245
See also:
Number Theory 1: Fermat's Dream - Kazuya Kato, Nobushige Kurokawa and Takeshi Saito
Number Theory 2: Introduction to Class Field Theory - Kazuya Kato, Nobushige Kurokawa and Takeshi Saito
Fermat's Last Theorem: The Proof - Takeshi Saito
Elliptic Curves, Modular Forms, and Their L-functions - Alvaro Lozano-Robledo
This book, together with the companion volume, Fermat's Last Theorem: The proof, presents in full detail the proof of Fermat's Last Theorem given by Wiles and Taylor. With these two books, the reader will be able to see the whole picture of the proof to appreciate one of the deepest achievements in the history of mathematics.
Crucial arguments, including the so-called \(3\)-\(5\) trick, \(R=T\) theorem, etc., are explained in depth. The proof relies on basic background materials in number theory and arithmetic geometry, such as elliptic curves, modular forms, Galois representations, deformation rings, modular curves over the integer rings, Galois cohomology, etc. The first four topics are crucial for the proof of Fermat's Last Theorem; they are also very important as tools in studying various other problems in modern algebraic number theory. The remaining topics will be treated in the second book to be published in the same series in 2014. In order to facilitate understanding the intricate proof, an outline of the whole argument is described in the first preliminary chapter, and more details are summarized in later chapters.
Graduate students and research mathematicians interested in number theory and arithmetic geometry.
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Prepackaged Water
If you don't have storage containers for your water, you can still have an emergency water supply at home. Prepackaged water provides you with clean, filtered water in cans, pouches, and boxes. Store in your pantry, in the fridge, or with your emergency food storage, so when disaster strikes, you'll still be prepared with that essential water.
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Mary Singler, Mind-Body Medicine PhD student
Mary SinglerMind-Body Medicine Student
"I quickly realized that I had found my home."
In 2007, Mary Singler stepped back from her job in the world of finance and realized that it wasn't what she wanted. She was 56 years old with a Masters in clinical nursing and had left the medical profession; but it hadn't left her.
"I found that I was always talking with clients, company owners, and fellow executives about health issues," she said, "so I decided to follow my life-long passion of health education." That meant going back to graduate school to acquire new skills.
When she looked at Saybrook, Singler found a program that fit her long-term goal to become not just an educator, but an educator prepared to reshape the American healthcare system.
"Saybrook's Mind-Body Medicine program is at the cutting edge in education dynamics, and in incorporating all the facets of what constitutes health - mind, body, and spirit - in order to make a healthier America."
After she graduates, Singler plans to use her PhD to teach physicians, nurses, and the general public about heart health. She's also interested in becoming certified as a hypnotherapist, specifically to work with women with cardiovascular disease. "I believe Saybrook will become known as a forerunner across the world in.... how to better attain an improved state of health and sense of well-being."
Without a doubt, Singler will be among those in the lead.


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The State Engineer received the following Application(s) in Carbon
County (Locations in SLB&M).
For more information or to receive a copy of filings, visit
http://waterrights.utah.gov or call 1-866-882-4426.
Persons objecting to an application must file a CLEARLY READABLE
protest stating FILING NUMBER, REASONS FOR OBJECTION, PROTESTANTS`
NAME AND RETURN ADDRESS, and any request for a hearing. Effective
July 1, 2009, there will be a $15.00 fee for each protest filed.
Protest must be filed with the State Engineer, Box 146300, Salt Lake
City, UT 84114-6300 on or before NOVEMBER 10, 2010. These are informal
proceedings as per Rule R655-6-2 of the Division of Water Rights.
(The Period of Use is generally year-round except irrigation which is
generally from Apr 1 to Oct 31 each year.)
90-1866 (F78166): Bill Barrett Corporation propose(s) using 161.3
ac-ft. from groundwater (19 miles NE of Sunnyside) for INDUSTRIAL:
from Jul 1 to Jun 30.
Kent L. Jones, P.E.
Published in Sun Advocate on October 14 and 21, 2010.


text:
Trayvon Martin (Family photo)
One year ago today, tragedy hit a quiet community in Florida when neighborhood watch leader George Zimmerman fatally shot teenager Trayvon Martin. The shooting has reverberated far beyond Sanford with people across the country trying to make sense of it and many mourning another young man gone too soon. While we may never know what really happened on that rainy night, the impact of the shooting will continue to be felt – by Trayvon's family and friends seeking justice, and by a nation grappling with the role of guns in the wake of the shooting deaths of children from Connecticut to Chicago and beyond.
Throughout the hearing and ongoing gun debate, our thoughts will be with Trayvon's family.
[View the story "Remembering Trayvon Martin" on Storify]Remembering Trayvon MartinOne year ago today, tragedy hit Sanford, Florida when neighborhood watch leader George Zimmerman fatally shot teenager Trayvon Martin. The reverberations from the shooting are still being felt. Here's a look at how people across the country are remembering Trayvon on the anniversary of his death.Storified by Legacy.com· Tue, Feb 26 2013 09:56:04ONE YEAR LATER: join parents of Trayvon Martin for #MillionHoodies Candlelight Vigil. 2.26 Union Square NYC 6PM http://twitpic.com/c5p0ac RTMichael SkolnikWSVN-TV - Family and friends rally to remember Trayvon MartinNORTHEAST MIAMI-DADE, Fla. (WSVN) -- Political activists Jesse Jackson and Al Sharpton were among more than a hundred activists who atten...Jamie Foxx Discusses Trayvon Martin, Gun Violence; Ben Crump On Upcoming Stand Your Ground HearingrolandsmartinPlease join us for a Candlelight Prayer VigilIn remembrance ofTrayvon MartinAnd all the lives lost to senseless violenceIn Chicago and NationwideHonoring the life and nonviolent vision ofDr. Martin Luther King Jr.TuesdayFebruary 26, 20136:30 p.m.Marquette ParkCorner of 67th and CaliforniaFebruary 26th marks the 1st anniversary of the tragic killing of Trayvon Martin, who was fatally shot a few blocks from his father's home. In remembrance of his life, Black Youth Vote has initiated a nationwide prayer vigil in his name. Several cities across the country have joined the movement including Atlanta, Detroit, Birmingham, Philadelphia, and throughout Florida. We are asking any and all to come out on this day in remembrance of the life of Trayvon Martin, as well as praying for peace and honoring Dr. King's vision for a non-violent community. And finally acknowledge the young people who will never fulfill their TRUE POTENTIAL due to senseless violence.Contact Jamika Smith for more info(773) email@example.com L. NixonI Am Trayvon MartinEditor BRemember Trayvon Martin.Nommo GatheringWe haven't forgotten. #Trayvon #RIP #racismHus
Storified by Legacy.com· Tue, Feb 26 2013 09:56:04


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|Help Rolls From Samaritan's Purse to Storm Areas
|Written by Steve Frank
|Tuesday, 30 October 2012 11:14
Trucks rolled from the Samaritan's Purse emergency response facility in Wilkes County this morning, Karina Petersen saying that five programs managers have been send to specific areas for assessment. Their release said that four of them are currently north of Richmond,
Virginia and approximately heading to Wayne, New Jersey, the greater Philadelphia area, Baltimore, Maryland area and the Delaware and Virginia coastal areas. Three Disaster Relief Units were sent out from North Wilkesboro, North Carolina, to follow the program managers. Once needs have been assessed, the units will travel to the areas that most need help. And once response areas have been decided on, we will send shower trailers, generators, and other required equipment. She said that, "We anticipate that we will be helping with tree damage and mud outs, but will respond to other needs as necessary."
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A community in which webmasters can ask for help with topics such as PHP coding , MySQL , IT jobs, web design, IT security.
Moderators: macek, egami, gesf
OldManRiver wrote::help: First so you will know here are all the commands in my config file:
# Server Side Processing Configuration
# To parse .shtml files for server-side includes (SSI):
# (You will also need to add "Includes" to the "Options" directive.)
AddType text/html .htm .dhtml .html .shtml .php .xml
AddOutputFilter INCLUDES .dhtml .shtml .php
AddHandler server-parsed .dhtml .shtml .html .htm .xml .php
# Enable the PHP Server
#LoadModule php4_module "E:\Program Files\PHP Server\php.exe"
#LoadModule php4_module "E:\Program Files\PHP Server\php4ts.dll"
#LoadModule php4_module "E:\Program Files\PHP Server\sapi\php4apache.dll"
#AddModule mod_php4.c
AddHandler php-script .php
AddType application/x-httpd-php .php
#AddType application/x-httpd-php "/_php/php.exe"
#ScriptAlias /_php/ "E:\Program Files\PHP Server\php.exe"
#ScriptAlias /php/ "E:\Program Files\PHP Server\php.exe"
#ScriptAlias /._php/ "E:\Program Files\PHP Server\php.exe"
#ScriptAlias /.php/ "E:\Program Files\PHP Server\php.exe"
I ran the "php.exe -i" test from the Install.txt file. It ran OK
Then as I added the "LoadModule" and "AddModule" commands, one at a time,
running "RESTART" after each; I got errors on each.
If you can explain the relationship, dependencies, etc., which I cannot find
in any books or help files, then maybe debugging will be easier. Right now
I'm clueless!
Code: Select all
ScriptAlias /php/ "c:/php/"
AddType application/x-httpd-php .php
Action application/x-httpd-php "/php/php.exe"
OldManRiver wrote:I never got errors before now with the code:
LoadModule php4_module "E:\Program Files\PHP Server\sapi\php4apache.dll"
AddType application/x-httpd-php .php
AddHandler php-script .php
I'm getting this error:
Syntax error on line 815 of E:/Program Files/Apache Group/Apache2/conf/httpd.con
Cannot load E:/Program Files/PHP Server/sapi/php4apache.dll into server: One of
the library files needed to run this application cannot be found.
Sorry I'm so clueless on this!
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text:
The only problem I have with the audio version of this book is the narrator, Whenever he impresonates a woman I begin cracking up, it really sounds ..Show More »
Not sure if this was a sequel, per se, but the continuing adventures of Ty and Zane allowed the reader to pick up the story and continue on the journe..Show More »
I feel like these guys are family and I just want to shake 'em and say.... "Get it together!" But their's is a very believable relationship of two me..Show More »
Listening to this book is like visiting old friends. I read and re read this book many times and the audio version did not disappoint. If you are no..Show More »


text:
New York Knicks v Detroit Pistons
Amar'e Stoudemire of the New York Knicks dunks the ball during the... News PhotoAmar'e Stoudemire,Atlanta Hawks - Basketball Team,Auburn Hills,Ball,Basketball - NBA Pro,Basketball - Sport,Detroit Pistons,Match - Sport,Michigan,New York Knicks,Palace,Slam Dunk,Sport,Taking a Shot - Sport,USA,VerticalPhotographer Allen EinsteinCollection: National Basketball Association 2013 NBAEAUBURN HILLS, MI - MARCH 06: Amar'e Stoudemire #1 of the New York Knicks dunks the ball during the game between the Detroit Pistons and the Atlanta Hawks on March 6, 2013 at The Palace of Auburn Hills in Auburn Hills, Michigan. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and/or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. Mandatory Copyright Notice: Copyright 2013 NBAE (Photo by Allen Einstein/NBAE via Getty Images)


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Romance On High
Westchester Health & Life (01/02/2009)
ADVENTUROUS COUPLES WITH A PENCHANT for ancient history will fall in love with Hotel Caesar Augustus (www.caesar augustus.com) in Anacapri, a hilltop community located on the mountainous island of Capri in southern Italy. Situated on a scenic cliff 1,000 feet above the Bay of Naples, the ancient Roman style hotel once the secluded manor of an early 20th century émigré Russian prince provides captivating vistas, lavish accommodations and other top notch amenities. To arrive at this towering treasure, travelers must first take a ferry or hydrofoil from Naples to Capri's port of Marina, then take a taxi, bus or shuttle to the hotel. Lovers can choose to stay in one of 55 luxurious deluxe rooms and junior suites equipped with king size beds, plasma TVs and private balconies facing the water or gardens. Or choose one of four premier "special suites," each with its own design scheme featuring kingsize beds, Jacuzzis and a living room area with terraces. By day, take a romantic stroll through the hotel's fragrant gardens and relax on sun loungers near the sea blue infinity pool. When night falls, enjoy a candlelit dinner together at Lucullo Terrace (see right), the hotel's new poolside restaurant featuring local cuisine. But why simply view Capri as a backdrop? A host of must see attractions are accessible to the hotel: A 20 minute chairlift ride to Mount Solaro the highest point of the island at 1,932 feet will take your relationship to new heights, while a tour of the ruins of Villa Jovis at Mount Tiberio once home to Roman Emperor Tiberius will provide a glimpse into Capri's history. Finally, no trip to Capri is complete without visiting the famous Blue Grotto, a natural sea cave on the island's coast, accessible by motorboat. It becomes illuminated by a magnificent blue glow when sunlight passes through its narrow entrance. To experience all Capri and Caesar Augustus have to offer, try the "Scent of the Blue Island" package. Offered for a three night minimum, it provides couples with flowers and limoncello upon arrival, private guided walking excursions to various sites, a dinner at Lucullo, a visit to the Blue Grotto, a massage for two and more. (Rates start at $3,197 per couple.) A TABLE TO TRY Lucullo Terrace (011 39 081 8373395) while dining on authentic local cuisine at this elegant restaurant in Hotel Caesar Augustus. Executive Chef Giuseppe Resta uses fresh produce to create tantalizing dishes such as black tagliolini pasta with sea urchins and crab.


text:
15 U.S. Code § 260 - Congressional declaration of policy; adoption and observance of uniform standard of time; authority of Secretary of Transportation
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It is the policy of the United States to promote the adoption and observance of uniform time within the standard time zones prescribed by sections 261 to 264 of this title, as modified by section 265 of this title. To this end the Secretary of Transportation is authorized and directed to foster and promote widespread and uniform adoption and observance of the same standard of time within and throughout each such standard time zone.
Source(Pub. L. 89–387, § 2,Apr. 13, 1966, 80 Stat. 107; Pub. L. 97–449, § 2(c),Jan. 12, 1983, 96 Stat. 2439.)
1983—Pub. L. 97–449substituted "Secretary of Transportation" for "Interstate Commerce Commission".
Effective Date
Pub. L. 89–387, § 6,Apr. 13, 1966, 80 Stat. 108, provided that: "This Act [enacting this section and sections 260a, 266, and 267 of this title and amending sections 261 to 263 of this title] shall take effect on April 1, 1967; except that if any State, the District of Columbia, the Commonwealth of Puerto Rico, or any possession of the United States, or any political subdivision thereof, observes daylight saving time in the year 1966, such time shall advance the standard time otherwise applicable in such place by one hour and shall commence at 2 o'clock antemeridian on the last Sunday in April of the year 1966 and shall end at 2 o'clock antemeridian on the last Sunday in October of the year 1966."
Short Title
Pub. L. 89–387, § 1,Apr. 13, 1966, 80 Stat. 107, provided: "That this Act [enacting this section and sections 260a, 266, and 267 of this title and amending sections 261 to 263 of this title] may be cited as the 'Uniform Time Act of 1966'."
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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For Bella Swan, there is one thing more important than life itself: Edward Cullen. But being in love with a vampire is more dangerous than Bella ever could have imagined. Edward has already rescued Bella from the clutches of an evil vampire, but now, as their daring relationship threatens all that is near and dear to them, they realize their troubles may just be beginning.
Legions of readers entranced by the New York Times bestseller Twilight are hungry for more, and they won't be disappointed by this gripping sequel. In New Moon, Stephenie Meyer delivers another irresistible combination of romance and suspense with a supernatural twist. Passionate, riveting, and deeply moving, this vampire love saga is well on its way to literary immortality.
"Fans of Meyer's debut novel, Twilight, may be disappointed in this second book in a planned trilogy. It begins with a bang, on Bella's 18th birthday, when Edward Cullen sweeps her off to his unorthodox family home (in the first book readers learn that the Cullens are vampires who hunt animals rather than humans) for a birthday celebration. But when Bella unwraps a gift and gets a paper cut, her drops of blood set off a chaos that culminates in the Cullens leaving town. Edward exits on page 73, and does not reappear for nearly 400 pages, except for his voice in Bella's head when she embarks on dangerous adventures, such as motorcycle riding and cliff diving. Instead, this book focuses on Jake, her friend from La Push, who has some unusual traits of his own. A Quileute legend that he confides in Bella in the first book comes to the fore here (and ties in with the title), and Bella is tracked down by the 'bad' vampires from the first book, who seek revenge for Edward's murder of their friend James. Long stretches in the book may make readers feel as if they're treading water, but the pace quickens when Alice Cullen sees a vision of Bella cliff diving and mistakes it for suicide. Edward then heads to the all-powerful Volturi vampires in Italy, seeking his own death. Will Bella get to Italy in time to save Edward? Will she remain human? Meyer answers the first question but leaves the second for the third novel. Ages 12-up. (Sept.)" Publishers Weekly (Copyright Reed Business Information, Inc.)
"New Moon will more than feed the bloodthirsty hankerings of fans of the first volume and leave them breathless for the third." School Library Journal
Meyer delivers another irresistible combination of romance and suspense with a supernatural twist. Star-crossed lovers Bella and Edward find themselves facing new obstacles, including a devastating separation, in this vampire love saga.
Star-crossed lovers Bella and Edward face new obstacles in this vampire love story--the second installment of Meyer's #1 "New York Times"-bestselling Twilight saga.
Legions of readers entranced by Twilight are hungry for more and they won't be disappointed. In New Moon, Stephenie Meyer delivers another irresistible combination of romance and suspense with a supernatural twist. The "star-crossed" lovers theme continues as Bella and Edward find themselves facing new obstacles, including a devastating separation, the mysterious appearance of dangerous wolves roaming the forest in Forks, a terrifying threat of revenge from a female vampire and a deliciously sinister encounter with Italy's reigning royal family of vampires, the Volturi. Passionate, riveting, and full of surprising twists and turns, this vampire love saga is well on its way to literary immortality.
About the Author
Stephanie Meyer holds masters' degree in education and social work and has dedicated her life to the welfare of youth.
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Ford Launches Fifth Plug-In Hybrid Car At Michigan Plant
A Ford worker loads a battery into a Ford C-MAX plug-in hybrid... News PhotoAlternative Energy,Alternative Fuel Vehicle,Battery,Car,Electricity,Finance,Ford Motor Company,Fuel Efficient,Horizontal,Hybrid Car,Hybrid Vehicle,Launch Event,Michigan,Mode of Transport,Occupation,Panoramic,Production Line,Technology,Transportation,USAPhotographer Bill PuglianoCollection: Getty Images News 2012 Getty ImagesDETROIT, MI, - NOVEMBER 8: A Ford worker loads a battery into a Ford C-MAX plug-in hybrid vehicle on the assembly line at the Michigan Assembly Plant November 8, 2012 in Wayne, Michigan. The plant is the only one in the world that builds vehicles with five different fuel efficient powertrains on the same line. Ford held an event today at the plant that celebrated the launch of the C-MAX Energi plug-in hybrid. (Photo by Bill Pugliano/Getty Images)


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Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to determine the clinical response to daily Indinavir oral administration in association with a conventional chemotherapy based on cycles of systemic Vinblastine +/- Bleomycin in patients affected by advanced classical (non HIV-associated) Kaposi's sarcoma
Kaposi's Sarcoma
Drug: Indinavir in association with Vinblastina +/- Bleomicina
Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Phase II Trial for the Treatment of Advanced Classical Kaposi's Sarcoma With the HIV Protease Inhibitor Indinavir in Combination With Chemotherapy
- to determine the rate of complete responses at the end of treatment (including the maintenance phase) and of clinical responses after the maintenance phase, considering the residual debulked tumour (after the induction phase) as the reference point. [ Designated as safety issue: No ]
- to determine time to tumor progression, treatment tolerability, indinavir pharmacokinetic profile, biological markers of response (ie. angiogenesis and immunoactivation parameters, HHV8 viral load and immune response) [ Designated as safety issue: Yes ]
|Study Start Date:
|June 2008
|Estimated Study Completion Date:
|December 2015
|Estimated Primary Completion Date:
|October 2015 (Final data collection date for primary outcome measure)
Drug: Indinavir in association with Vinblastina +/- Bleomicina
It has been recently demonstrated that HIV protease inhibitors (HIV-PI) exert direct anti-angiogenic and anti-tumor actions by blocking endothelial and tumor cell invasion and matrix metalloprotease (MMP) activity. Based on this data, we have started a phase II trial for the treatment of HIV-negative patients with CKS with the HIV-PI Indinavir. Indinavir was well tolerated and induced KS regression/improvement in early-stage disease, and prolonged stabilization in late-stage KS. Response required high plasma drug concentrations indicating a "therapeutic" drug threshold, and was associated with a decrease of circulating endothelial cells (CEC), basic fibroblast growth factor and MMP2 plasma levels. However, large, confluent tumor masses were generally not responsive (Monini et al, AIDS 2009). Thus, advanced KS may benefit at best by treatment with IND upon tumor debulking by conventional chemotherapy.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Documented diagnosis of KS
- Negative HIV ELISA test
- Being classified as stage III or IV
- Age ≥18 years
- Having interrupted any other anti-KS therapy since at least 2 weeks
- Being informed about the nature of the study and having signed the informed consent
Exclusion Criteria:
- Inability to give informed consent
- Presence of other concomitant diseases, neoplasia (excluding cutaneous tumors with limited extension and without diagnosis of melanoma) or any other life-threatening clinical condition that would compromise its compliance to the protocol
- Concomitant treatments (within 2 weeks prior to the study) with systemic immunomodulatory agents (i.e. glucocorticoids used as immunosuppressive agents, interferons) or chemotherapy
- Pregnancy
- Monolateral nephropathy or history of nephrolithiasis during the last 5 years
- Any clinically relevant and persistent alteration of laboratory values observed during screening
Please refer to this study by its ClinicalTrials.gov identifier: NCT01067690
|Dermatologic Unit, Ospedale Maggiore Policlinico, Milan, Italy
|Milan, Italy, 20100
|Principal Investigator:
|Lucia Brambilla, MD
|Dermatologic Unit, Ospedale Maggiore Policlinico, Milan, Italy
Additional Information:
|Responsible Party:
|Barbara Ensoli, MD, MD, Istituto Superiore di Sanità
|ClinicalTrials.gov Identifier:
|NCT01067690 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 10, 2010
|Last Updated:
|September 1, 2015
|Health Authority:
|Italy: The Italian Medicines Agency
Keywords provided by Istituto Superiore di Sanità:
classical Kaposi's sarcoma
HIV protease inhibitor
Advanced classical (non HIV-associated) Kaposi's sarcoma
Additional relevant MeSH terms:
Sarcoma, Kaposi
DNA Virus Infections
Herpesviridae Infections
Neoplasms by Histologic Type
Neoplasms, Connective and Soft Tissue
Neoplasms, Vascular Tissue
Virus Diseases
HIV Protease Inhibitors
Protease Inhibitors
Anti-HIV Agents
Anti-Infective Agents
Anti-Retroviral Agents
Antiviral Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Therapeutic Uses
ClinicalTrials.gov processed this record on October 13, 2015


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WASHINGTON, D.C. (WUSA) - A decade after the sniper attacks that terrorized our area and left a trail of bloodshed, one of the two men responsible for the violence has spoken from behind bars in a rare interview.
In the interview published by the Washington Post on Sunday, convicted sniper Lee Malvo describes himself as a monster and shares the moment that stood out for him.
Andrea McCarren has listened to the interview and is here to tell us more.
The Washington Post shared with us parts of its recorded phone calls with Lee Malvo. In chilling detail, he talked about the crimes, his victims and their families.
"What am I going to tell them? I'm sorry I murdered your own child. I'm sorry I killed your husband. I'm sorry I murdered your wife," Malvo said.
Lee Malvo, now 27, said he felt like the worst piece of scum on the planet when he saw the anguished expression on the face of the husband of one of his victims. As Linda Franklin lay in a pool of blood outside the Home Depot in Falls Church, Malvo said her husband's eyes reflected the worst sort of pain he'd ever seen in his life.
"I am sorry. I am sorry," he said.
For so many of us, involved in the news coverage every day, it was a frightening time.
At any moment, it felt like another random victim might be shot. Today, Malvo says he was a monster.
"If you look up the definition, that's what a monster is. I was a ghoul. I was a thief. I stole people's life.... What do I tell the child who is waiting for his father to come home? And dad never showed up," he said.
Malvo also described in frank terms how he and Muhammad carried out their deadly crime spree, including 27 shootings across the country.
"We'd go in the trunk. I'd put my window down half way and I can see whatever is in front of me, to my left and to my right. My focus is on witnesses, passengers (tighten up!) and whenever there was an opening, I told him to shoot.... And it was just one rapid (snaps fingers) after another after another after another. If there wasn't an opening within ten minutes, we moved," he said.
One of the more disturbing elements of Malvo's interview is that he urges the victims families to move one. He said, "Don't allow myself or Muhammad to continue to make you a victim for the rest of your life. It isn't worth it."
People may wonder, just how did Muhammad convince Malvo to carry out such horrific acts?
Remember Malvo was just 17 at the time. He'd been abandoned by his mother. His father wasn't around. Muhammad became a father figure, who offered consistency. Even though, as Malvo said, that consistency was madness.


text:
I used to love "Meet the Press," the Sunday morning TV show where I'd gain new insights into a pressing public issue. Today the show feels more like a platform for propaganda from different sides of the political debate.
The second half of life transforms our understanding in ways that can transform our world.
For example, when guest Rachel Maddow tried to dig into the "fundamental disagreement about the facts" between Democrat's and the GOP's view on women's economic issues, it could have been an opportunity for host David Gregory to add, "Might both arguments be true?" We, the audience, could have discovered how the issue is far more complex than the simplistic explanations offered by the propagandists. But it wasn't understanding that increased, just the volume from each side spouting its pre-planned comments and incomplete solutions.
The demise of what I (and many others) valued in "Meet the Press" is symptomatic of a larger trend in our society: an increasing polarization that is causing more harm than good. The problem has been described very well by Father Richard Rohr, a Franciscan priest and founder of the Center for Action and Contemplation in Albuquerque, New Mexico. Rohr has a terrific new book called, "Falling Upward: A Spirituality for the Two Halves of Life" (Jossey-Bass, 2011).
"Nothing is going to change in history as long as most people are merely dualistic, either-or thinkers. Such splitting and denying leaves us at the level of mere information, data, facts and endlessly arguing about the same, 'My facts are better than your facts,' as we yell at ever higher volume and with ever stronger ego attachment," Rohr wisely writes.
It need not be this way. The first half of life, Rohr argues, is full of ego, persona and black-white judgmental thinking. Some people remain stuck here all their lives. Others enter the second half of life by experiencing a significant failure of some type. If we are open to learning, we're then resurrected by accepting our whole self, warts and all. In so doing, we can truly love and initiate what our soul – i.e., our original blue print and our deepest meaning – calls us to do. In the second half of life we see the whole truth – multiple sides of arguments and the joy and tragedy in each moment of life.
As the baby boom ages, more of us will be entering the second half of life and searching for deeper meaning. At the same time, new information technology will aid our search for deeper understanding in all aspects of our lives: personal, professional and political. Information technology both creates new data and makes it accessible, shedding light into the numerous black boxes that define "how things get done." Concurrently, social media is giving us far more opportunity to share information and increase influence.
The light of transparency and use of social media will democratize and transform industries by dramatically changing access, as Mark McDonald noted in a recent WTN blog. For example, the Internet and then Amazon created consumer access to brands beyond what local stores offered, transforming retail markets. Rob McCray, CEO of the Wireless Life Sciences Alliance, reminded me how Napstar and M3 players made the entire world of music available to everyone. In the process, how music got delivered changed dramatically – from albums to singles, with less control by music studios and more control by musicians who can reach consumers directly through websites, YouTube, etc.
Healthcare will be transformed as we learn more about which providers offer the most value and which preventative practices create better health. Consumer brands will be transformed as we learn more about egregious and laudable behavior on the part of different companies and, through social media, false brand promises. Voting may even be transformed as we figure out ways to gain more access into who is behind what money and ads. Alternatively, citizen-ballot direct-democracy initiatives like those in Colorado may grow, reducing politicians' power. Imagine if simple-to-use tools could help us mine government data and better understand fiscal issues freed of political parties' slants.
I expect the data created by new access will be messy – and not just from a data management sense. The data will both contrast with and support our a priori assumptions about how things really work. This is good.
Whole people – those in the second half of their lives – are the unifiers, the "yes-and" people who make ideas better. They are the ones who create a better world, not just criticize this one, according to Rohr. Our political institutions, communities and businesses need them. Become one if life's journey has not made you one already.
Kay Plantes is an MIT-trained economist, business strategy consultant, columnist and author. Business model innovation, strategic leadership and smart economic policies are her professional passions. She was an economic advisor for former Wisconsin Gov. Lee Dreyfus.


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DROP DATABASE drops all tables in
the database and deletes the database. Be
very careful with this statement! To use
DROP DATABASE, you need the
DROP privilege on the database.
SCHEMA is a synonym for
When a database is dropped, user privileges on the database are not automatically dropped. See Section 126.96.36.199, "GRANT Syntax".
IF EXISTS is used to prevent an error from
occurring if the database does not exist.
If the default database is dropped, the default database is unset
DATABASE() function returns
If you use
DROP DATABASE on a
symbolically linked database, both the link and the original
database are deleted.
DROP DATABASE returns the number of
tables that were removed. This corresponds to the number of
.frm files removed.
DROP DATABASE statement removes
from the given database directory those files and directories that
MySQL itself may create during normal operation:
All files with the following extensions.
db.opt file, if it exists.
If other files or directories remain in the database directory
after MySQL removes those just listed, the database directory
cannot be removed. In this case, you must remove any remaining
files or directories manually and issue the
DROP DATABASE statement again.
Dropping a database does not remove any
TEMPORARY tables that were created in that
TEMPORARY tables are automatically
removed when the session that created them ends. See
Temporary Tables.
You can also drop databases with mysqladmin. See Section 4.5.2, "mysqladmin — Client for Administering a MySQL Server".
|Posted by Christopher Schultz on February 26 2004 11:49am
|[Delete] [Edit]
Please note that when dropping databases containing InnoDB tables in version 4.0.18 and beyond, you might get a FK violation.
It sounds bizarre, but DROP DATABASE seemingly drops each table, first, in arbitrary order. Since the ordering is arbitrary, it may drop them in the 'wrong' order. In this case, you'll get the message:
error: 'Cannot delete or update a parent row: a foreign key constraint fails'
... and half of your tables will be gone, the other half remaining. You can repeatedly execute "DROP DATABASE" commands and each time (at least for me), MySQL gets closer to an empty database, at which point, the database itself is dropped.
Here's a mailing list thread covering the phenomenon and a few responses from someone who sounds like they're in a position to know about these things.
I marked this comment as an "Explanation" because I cannot mark it as a bug :(. I feel that there needs to be a way to drop a database without manually dropping all the tables inside it, first. MySQL should at least drop the tables in the reverse order in which they were added to the database, to avoid such behavior.
|Posted by [name withheld] on April 5 2004 11:22pm
|[Delete] [Edit]
before dropping a database fixes the foreign key constraint problem (as introduced in 4.0.18) for me
|Posted by Justin Vassallo on May 10 2005 1:02pm
|[Delete] [Edit]
Do note that when a db is dropped, the corresponding db structure is deleted. However, the data itself, which resides in a common file 'ibdata', is not deleted. In some cases, this might constitute a security hazard.
This is not a bug but i think that it would be a good idea that 'drop database' actually removes the data from ibdata.
|Posted by Jonathan Watt on May 28 2009 9:43pm
|[Delete] [Edit]
To drop all tables without actually dropping the database (fill out the first line as appropriate):
MYSQL="mysql -h HOST -u USERNAME -pPASSWORD -D DB_NAME"
$MYSQL -BNe "show tables" | awk '{print "set foreign_key_checks=0; drop table `" $1 "`;"}' | $MYSQL
unset MYSQL
This can be useful if all you really need to do is empty the database in order to restore a backup made by mysqldump, but you couldn't use --add-drop-database because you don't have CREATE DATABASE privileges on the command line (e.g. you're on shared hosting). mysqldump adds DROP TABLE by default, but if tables may have been added or renamed since the time of your backup (e.g. by some sort of update process that you're trying to revert from), failing to drop those tables will likely cause serious headaches later on.
Of course this raises the question of why MySQL doesn't support "DROP TABLE *;" (in which case mysqldump could just insert that)?
|Posted by Gary Aitken on June 20 2012 3:16pm
|[Delete] [Edit]
Note that mysql assumes any subdirectory in its data storage directory is a database. If you have mistakenly created a subdirectory there, "show databases" will indicate that directory as a known database even though you have never added a database of that name. Attempting to remove it will fail if you have placed anything in that directory. To remove it, copy / move the files someplace safe, then issue the drop database command.


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Classic Brownie Mix
- Try these delicious varieties today:
Pillsbury Brownie Mix Tips
- Do not bake brownie mix in toaster oven or microwave.
- For best results, preheat oven to 350ºF and place oven rack in the middle of the oven.
- We recommend spraying your pan with Pillsbury Baking Spray with Flour.
- If batter is too sticky, just add 1–2 teaspoons of water.
- Do not rest batter for more than 30 minutes.
- We do not recommend freezing or refrigerating brownie batter.
- For super-special treats, top each brownie with your favorite flavor of Pillsbury Frosting.
- Finish with candy bits, sprinkles, or decorator sugar.
Cappuccino Cheesecake Brownies
- Prep time: 15 mins
- Cook Time: 45 mins
- Yield: 3 dozen
Peanut Butter Brownie Cookies
- Prep time: 45 mins
- Cook Time: 12 mins
- Yield: 24 cookies
Festive Brownie Pops
- Prep time: 30 mins
- Cook Time: 30 mins
- Yield: 3 dozen
Sticky Toffee Brownies
- Prep time: 20 mins
- Cook Time: 40 mins
- Yield: 16 brownies


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BELFAST, Maine (NEWS CENTER)-- Business is booming for one Belfast company. Ducktrap River of Maine produces premiere smoked seafood. The demand for the product continues to grow so that the company can barely fill their orders.
General manager Don Cynewski said, "Our employees are working over 60 hours a week. We are producing everything we can and it's just keeping up with the demand. We are actually having to slow down our sales force a little bit."
Cynewski said the only solution is expansion. The plan includea opening 40 to 50 new jobs in Belfast plus expanding the production facility by almost 50 percent. The expansion carries a price tag of 4.5 million dollars.
Over the past four years Ducktrap River has seen an increase in demand for smoked seafood and growing interest in the product.
"The demand for smoke salmon is increasing in the United States. it's still a new item and sales will continue to grow and demand will continue to increase," said Cynewski.
The new positions will be filled over the next 4-5 years. Most of the expansion will take place in the production areas and include an additional smoker to keep up with the increasing demand.


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Visit our other brands: danishdesignstore.com, adogslife.net
It's easy to find tacky, gaudy, or just plain overcomplicated lamps--the kinds of lamps you'd expect to see at a themed hotel. I was out shopping the other day and saw a lamp with a gilded base in the form of (get this) an elephant carrying on its back a monkey holding a stick that bore a cockatoo on one branch and the light bulb and red-and-gold-brocade lampshade on the other branch. It was actually...read more


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Despite the outlook for U.S. and European economies being highly uncertain, the U.S. dollar and the euro remain the world's dominant currencies. However, the importance of these two currencies is diminishing, which is not surprising given the huge debt problems in both markets. In order to hedge against a further devaluation of the two currencies, investors are increasingly looking beyond their own borders to find attractive investment opportunities. Currency diversification should be a key focus; that's now obvious to everyone. But what should you do once the dollars or euro have been exchanged to Singapore dollars, Norwegian crowns or Swiss francs? While holding cash in those currencies certainly seems to be a short-term option, people need to find investment ideas where they can put their money to work in the long term.
It is admittedly a rather difficult task to find good investments today; this is especially true for equities. With the U.S. and Europe looking less attractive for the reasons mentioned above, investors naturally need to start looking at some emerging markets. There, they can still find good companies with excellent growth potential and attractive valuations. From a geographical point of view, it seems to make sense to diversify into emerging markets. But what industries are attractive in those markets? Selecting investments and looking for investment opportunities don't get much easier if one compares different industries. For example, investing in banking stocks seems very unattractive in many markets given the fact that there is a global trend toward stricter banking regulations and requirements to hold higher capital reserves. Globally, regulators hope to make the world's banking system more stable by requiring banks to hold more capital. From an investment point of view, this means that many of these companies will probably see a prolonged period of time with moderate or even disappointing profit growth.
In some of my previous articles, I have written extensively about some interesting markets and industries such as commodity- and agriculture-related investment opportunities. Today, I would like to make a strong investment case for Asian healthcare companies. I believe this is an industry with tremendous growth potential in the next decade (and most likely beyond that). However, few people are aware of the exciting opportunities there. And, yes, I know. Many people probably can't hear the word "healthcare" anymore, because there has been too much negative noise about it in connection with the healthcare bill in the U.S. However, with Western countries struggling to control their rapidly increasing healthcare cost, the dynamics in the Asian healthcare market are very different. People in Asia have a fundamentally different relationship to healthcare. For many people, having access to good medical facilities is viewed as a prestige thing. This also explains why Asians spend so much money for lifestyle medicine and plastic surgeries. With fast-growing middle classes in many Asian countries, the demand for good, quality healthcare is rising very rapidly.
The global healthcare market consists of various subsectors that include pharmaceutical companies, hospital operators and biotech and medical technology companies, just to name a few. While growth rates in Western markets are slowing, the healthcare industry in Asia is growing at a rate of about 15 percent annually; some subsectors experience even higher growth rates. Healthcare penetration is still low in most Asian countries, and very few people have private health insurance. Also, healthcare infrastructure is well below Western levels. India, for example, has only 1.27 hospital beds per 1,000 people, that is less than half the global average of 2.6 and far away from the four beds per 1,000 people recommended by the World Health Organization. Demographic factors, as well as increased government and private-sector activity, will increase healthcare penetration. This will initiate a massive amount of investments in the sector. Again to take India as an example, it is expected that about $180 billion will be spent in the next five years on healthcare infrastructure alone.
There are enough positive domestic drivers that make the Asian healthcare market attractive. However, on top of the domestic factors, there is also increasing demand coming from other sources, such as medical tourism. With more and more people in the West struggling to afford medical costs, the incentive to look for treatment abroad is growing quickly. For example, a hip-replacement procedure costs between $25,000 and $40,000 in North America and Europe. The exact same procedure costs about $10,000 in places like Thailand or India. So for many people, this becomes a real option, maybe even the only option. Current data suggests the medical tourism market is growing at a rate of about 40 percent annually. This will add further momentum to an already booming market, and the underlying demographic trend suggests the Asian healthcare market will continue to grow at a rate of about 15 percent for at least another decade.
There are various ways investors can take an exposure to this promising market, but the most obvious way is to invest in Asian healthcare companies or Western companies with a high exposure to this booming market. In our view, it makes sense to select companies that have a diversified business model across several key markets in Asia. Given the fact that government's role in regulating healthcare in each of these Asian countries is still very important, the political risk should not be underestimated. Also, investors should carefully review each company and its actual business. Here again, it is probably not ideal to select smaller companies with a very narrow focus on one small niche. This is often the problem with some of the medical-technology companies. Among our favorite investments are larger, well-diversified companies that can generate returns from a number of different markets and from various business channels. We currently view hospital and clinic operators as one of the best ways to invest in the growth of the Asian healthcare market.
The chart below shows the price development of two of the most popular Asian Healthcare market indices, the FTSE ST Healthcare Index (Singapore) and the BSE Healthcare Index (India). Both indices have rallied strongly after the sharp correction in 2008; however, both markets have achieved attractive returns in the past couple of years.
This is in sharp contrast to most large-cap healthcare stocks that are primarily focusing on Western markets. The chart below shows the historical performance of three of the most popular healthcare stocks in North America (Abbott Laboratories, Pfizer, Medtronic). Many of these companies have performed very poorly in the past decade and have even generated negative returns for investors. Of course, the past decade certainly saw a time of disappointing stock market returns, but it is surprising that not even healthcare companies have been able to generate decent returns.
There are, of course, also Western healthcare companies, which will benefit from the growth in Asia and other emerging markets. Therefore, some of these Western companies could also see better times ahead, both in terms of their sales and profits and, hopefully for investors, in the form of higher stock prices. Investors have to realize that a direct investment in Asian healthcare companies has more risk. These markets and the individual stocks are usually more volatile than their Western counterparts.
The rise of Asia will be one of the dominant investment themes in the next 20 years. The increased political power, rapid population growth and rising income levels will present a large number of attractive investment opportunities. But with high return potential also comes higher risk. That is the reason investors need to carefully select their individual investments. The Asian healthcare market is one of the most interesting investment themes today, a structural trend that will go on for many years and presents a great investment diversification for Western investors.