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Advanced Grandparental Age as a Risk Factor for Autism
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The Division of Medical Genetics at the University of Mississippi Medical Center is recruiting parents of children with a pervasive developmental disorder (including autism, autistic spectrum disorder, PDD-NOS, Asperger syndrome, childhood disintegrative disorder, and Rett syndrome) to participate in a study to help determine potential causes of the increasing prevalence of these disorders. The study is being conducted using an anonymous on-line survey available to parents through a secure link.
The study consists of approximately 90 questions about the affected child, siblings, parents, and grandparents, which will take roughly 10-15 minutes to complete. Several families will also be invited to participate in a phone interview. Both the survey and the phone interview are conducted using a self-designated code to protect anonymity and patient privacy. No identifying information such as name, date of birth, address, or phone number will be asked. Only questions regarding the year of birth of family members will be asked.
Autistic Disorder
Pervasive Developmental Disorder
Asperger Syndrome
Childhood Disintegrative Disorder
Rett Syndrome
|Study Type:
|Study Design:
|Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:
|Advanced Grandparental Age as a Risk Factor for Autism and Other Pervasive Developmental Disorders
|Study Start Date:
|June 2007
|Study Completion Date:
|October 2007
Autism is a genetically heterogeneous entity. Although numerous studies have demonstrated a strong genetic basis, no clear etiology has been identified to date. Recently, two studies have demonstrated an increased risk of autism in children born to fathers over the age of 40. However, given the large male-to-female predominance of autism, it is likely that new mutations on the X chromosome account for a significant number of affected cases. Due to the maternal origin of the X chromosome in males, we hypothesize that advanced maternal-grandpaternal age may also be a risk factor for autism. Precedence for this theory exists with other X-linked disorders such as Duchenne muscular dystrophy and Rett syndrome. Additionally, it has been demonstrated that maternal psychiatric illness, but not paternal psychiatric illness, is more prevalent among parents of children with autism. Using anonymous surveys of families with autistic children, we seek to identify the ages of grandparents at the time the parents were born in order to determine if advanced maternal-grandpaternal age is associated with an increased risk for autism when adjusted for advanced maternal and paternal age. Additionally, we will seek out sister-pairs in order to identify any statistical significance between the ages of the maternal grandfather at delivery of each sister. If advanced maternal-grandpaternal age is, in fact, a risk factor, it would help direct molecular researchers towards genes on the X chromosome as potential etiologies for autism. Also, further study of potential mutagenic exposures in the environment of grandparents may help elucidate the reason for the increasing incidence of autism in recent decades.
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Patients with any pervasive developmental disorder.
Inclusion Criteria:
- Individuals of any age with autism, autistic disorder, autistic spectrum disorder, Asperger syndrome, pervasive developmental disorder, PDD-NOS, Rett syndrome, or Childhood disintegrative disorder
Please refer to this study by its ClinicalTrials.gov identifier: NCT00464477
|United States, Mississippi
|University of Mississippi Medical Center
|Jackson, Mississippi, United States, 39216
|Principal Investigator:
|Omar Abdul-Rahman, MD
|University of Mississippi Medical Center
No publications provided
|ClinicalTrials.gov Identifier:
|NCT00464477 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 20, 2007
|Last Updated:
|November 6, 2007
|Health Authority:
|United States: Institutional Review Board
Keywords provided by University of Mississippi Medical Center:
Autistic disorder
Pervasive developmental disorder
Asperger syndrome
Childhood disintegrative disorder
Rett syndrome
Additional relevant MeSH terms:
Asperger Syndrome
Rett Syndrome
Autistic Disorder
Child Development Disorders, Pervasive
Developmental Disabilities
Genetic Diseases, Inborn
Genetic Diseases, X-Linked
Heredodegenerative Disorders, Nervous System
Intellectual Disability
Mental Disorders
Mental Disorders Diagnosed in Childhood
Mental Retardation, X-Linked
Nervous System Diseases
Neurobehavioral Manifestations
Neurodegenerative Diseases
Neurologic Manifestations
Pathologic Processes
ClinicalTrials.gov processed this record on October 13, 2015


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We are all Chasers and on any given day enamoured by one of the guys specifically. So what are the fans of each individual guy called?
I have seen "Lugnuts" for Mike's Fans. (I'm wonder about pronounciation? Does the lug sounds like hug or lug like "loogie"?)
Do fans decide or do the guys get to (or have done) the honor of naming their fans?

subset: commoncrawl


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The 2012 Islanders Draft Pick and Prospect Rankings (Part Three: #20-16)
This summer we'll be ranking all the prospects in the Isles' organization from top to bottom. The goal is to give you a picture of who is in the pipeline, what their chances are to someday be on the Islanders roster and to serve as a comprehensive guide for the team's current talent pool.
Previous entries:
Part One: #37-31
Part Two: #30-21
20. Jason Clark, C, 2010 3rd Round Pick
Junior, Wisconsin
2011-12 stats: 21G, 0-1-1, 8PIM
Clark is an interesting player and one that is going to have a very important next two seasons. He's coming off his sophomore season at Wisconsin where he didn't see very much playing time. Clark accumulated only 15 SOG all year, so don't let the stat line automatically convince you that he's a lost cause. It's tough to judge a player when he's not getting in the game (although that in itself could be a red flag, of course). That was the same story as his freshman year at UW, one that required off-season hip surgery.
However, Clark's pedigree is enough for us to keep him in the Top 20, hoping that he'll have a solid final two seasons in Wisconsin with some upperclassmen moving out and giving him more playing time. He's got a solid pedigree, spending two years at Shattuck-St. Mary's in Minnesota and scoring more than a point-per-game there. We'll have to wait and see if he can step up at Wisconsin before passing any final judgement on him. He's a 6-foot-2 center, something that would be a nice addition to the Bridgeport pipeline.
19. Rhett Rakhshani, RW, RFA
24 years old, Bridgeport (AHL)
2011-12 stats: 49G, 20-29-49, 42PIM, +25
One of the best players statistically on the Sound Tigers this year was Rakhshani, who put up a point per game in the AHL. I feel like I'm making a mistake ranking him this low but the truth is that he's yet to prove himself at the NHL level. He had five games with the Islanders last season (granted, very small sample) and wasn't able to hold onto a spot on the league's 27th best team. If the Islanders do re-sign him, and they should, it'll be an interesting year for the 24-year old. He's going to have very serious competition to make the big club from some of the forwards coming later in this feature. Hockey's Future projects him as a career AHL player; can he shake that mold?
See also: IPB's January 2012 feature on Rakhshani
18. Mark Katic, D, RFA
23 years old, Bridgeport (AHL)
2011-12 stats: 14G, 0-4-4, 6PIM, -3
Back in June 2009, the Islanders had three prospects playing for the Sarnia Sting of the OHL: Matt Martin, Justin DiBenedetto and Katic. Chris Botta called Martin the "surest thing", and it turns out CB was right on the money as Martin has made a solid impact on the Island for the past two seasons. He also gave Katic the mark of having the biggest upside from the trio, as Katic was one of the leading scorers on the Sarnia team as a defenseman.
In the second half of 2009, Katic made the jump to the AHL and found success as a quick, puck moving defenseman in Bridgeport. He had two solid years and was called up to the Islanders at the end of 2010-11 for 11 games. Things were looking right on schedule for Katic until he hit a major roadblock last September. He injured his left shoulder, requiring season-ending surgery, the second time he has had surgery on that wing. As LHH noted, it was a catastrophic turn of events for a promising young defender who was in the third year of his ELC. He did return late in the year to play 11 games for the Sound Tigers, but it was still a lost season. The Islanders now must make a decision on Katic and whether to hold onto him with a depth chart that is chock full of "fast, puck moving defensemen."
17. Justin DiBenedetto, LW, RFA
23 years old, Bridgeport (AHL)
2011-12 stats: 55G, 20-21-41, 73PIM, +7
Right along with Katic is Justin DiBenedetto, whom the Islanders have an RFA decision to make. DiBenedetto had an excellent year in Bridgeport, upping his point total for the third straight year. He's 5-11, full of energy and gets under opponents' skin. The best part? He's got a scoring touch. The downside to DiBo is that he's at most a third line wing on the NHL level, he's not a high-end talent (although I'd love to be proven wrong). There's no reason for the Islanders to not come to terms with him this summer, it's a matter of finding a spot for him. He should be given every chance to fight for a spot in camp this fall.
16. Aaron Ness, D, 2nd year of ELC
22 years old, Bridgeport (AHL)
2011-12 stats: 69G, 5-22-27, 36PIM, +8
Ness got the call for nine games last year on the Island and fit in fairly well, looking like he could have a future with the big club with a little improvement. He's probably the biggest challenge to Mark Katic's future, as Ness is the younger version of Katic (and a bit smaller and quicker). Two of the biggest positives that we did see during his short time on the Island was his passing ability and quickness that could give him a leg up going into camp. The knock on him is certainly his size as he is *listed* at only 5-10, 170. In a organization with a lot of defensemen cut from this mold, it will certainly be a tough fight to make it to the big club.
See also: IPB's January 2012 feature on Ness


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If you are looking to enjoy the many wonderful restaurants that New York has to offer, Restaurant Week is the perfect way to see them all without breaking the bank.
Thursday, September 06, 2012 - Sunday, November 11, 2012
Pennsylvania Avenue NW between 13th Street NW and 14th Street NW
Event website >
The Broadway production earned 11 Tony nominations in 2006, and this cast is of that very same standard. Only running in DC for two months, don't miss this inspirational story of hope featuring jazz, gospel and blues melodies. This is an absolute must see, bringing an uplifting and empowering feeling, you are sure to leave the theater with a night full of memories.
< Radar


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PALM CITY -- Commando Zeus.
ST. JOSEPH, Mich. -- Beagle Butch window shops at the pet bakery.
STUART -- Nap time for two.
STUART -- Sam and Charlotte are friends forever, even in tough economic times!
VERO BEACH -- This is Bruce Dimock's best friend Bailey.
FORT PIERCE -- This is my cat Simon and a sandhill crane in my front yard.
JENSEN BEACH -- Sammie, Louie, and Bailey love lizzard watching.
STUART -- Joey is a shy, playful kitten who loves his kitty food!
MARIETTA, Ga. -- Big Charlie.
FORT PIERCE -- My cat Berry, brother to Blue, jumped to the lamp and climbed up. Then he started to climb in the lamp top. Taken with a Kodak Z712 Easy Share. Blue and Berry were adopted from the SLC Humane society.
HUDSON, Mass. -- This is a picture of my "granddaughter" Lacey. She loves to sneak up on the couch for her naps.
STUART -- Can I move in here and have my babies? Taken with a Nokia cell phone outside my mother's home in Twin Lakes.
STUART -- Stashu is 8 years old and likes to sleep in.
PORT ST. LUCIE -- Best of friends. Kodiak, 3 months old, and Savannah, 8 months old, (both golden retrievers) share a stick in the yard.
STUART -- Homer and Caymen relaxing in the sun.
FORT PIERCE -- Sunning in the pencil cactus.
PORT ST. LUCIE -- Little Lady just loves Walton Rocks Beach!
PORT ST. LUCIE -- Shhh! Let sleeping puppies lie.
VERO BEACH -- Spencer Boy in his bowl.
PALM CITY -- Little Ga Ga Gooch.
PALM CITY -- Sammy and Tattoo.
PALM CITY -- Purrrrfect chair for Bo Bo.
PALM CITY -- Majestic Okie.
PALM CITY -- Sammy.
PALM CITY -- Boy Boy's spot.
PALM CITY -- Good Old Sammy.
PALM CITY -- Okie's favorite sleeping spot.
PALM CITY -- Little Okie.
PALM CITY -- Sammy and Tattoo poolside.
STUART -- Drugi and Kryshia love to smile!
STUART -- Cat enjoying a cool off in the sink. Cotee is a new member to our family. He was saved from going to the Human Society.
STUART -- Mama and her seven babies at Tropical Ranch Botanical Gardens.
PORT ST. LUCIE -- Cat in the hat?
STUART -- Izzy doing what he does best.
VERO BEACH -- Getting to know you. A sandhill crane visits our cat.
PORT ST. LUCIE -- Carmine chillin' on the cool tile floor.
PORT ST. LUCIE -- Duke say's it's getting hotter and dryer every day with not much sign of rain. So, don't discard cigarette butts from your car window and help reduce the chances of accidental brush fires.


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My wife used this doctor as her OBGYN for years without too much of an issue, but once she got pregnant this past year the problems with the office became very apparent. Beddow started out dealing with my wife's pregnancy as if she was going to be able to deliver the child, but as we advanced through the process, and started paying as if she was going to be delivering the child. Later it was discovered that she will only deliver at one hospital in San Mateo. At the beginning, she gave us a price list saying that her staff would determine the co-pay. We never heard back from them so we assumed there was no co-pay and decided that we would make San Mateo work. Contrarily, they billed us directly, without contacting our insurance and when we called to question what was going on. The staff claimed the procedure was to wait until 38 weeks of pregnancy before checking benefits, and then the full bill is due. Attempts to talk to the Doctor directly are blocked by the administrative staff.
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I really liked Dr. Beddow. She's very sweet, patient and takes her time asnwering your questions. She's great.
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"Children, obey your parents in everything, for this pleases the Lord. "
Colossians 3:1 If then you have been raised with Christ, seek the things that are above, where Christ is, seated at the right hand of God.
Colossians 3:2 Set your minds on things that are above, not on things that are on earth.
Colossians 3:3 For you have died, and your life is hid with Christ in God.
Colossians 3:4 When Christ who is our life appears, then you also will appear with him in glory.
Colossians 3:5 Put to death therefore what is earthly in you: fornication, impurity, passion, evil desire, and covetousness, which is idolatry.
Colossians 3:6 On account of these the wrath of God is coming.
Colossians 3:7 In these you once walked, when you lived in them.
Colossians 3:8 But now put them all away: anger, wrath, malice, slander, and foul talk from your mouth.
Colossians 3:9 Do not lie to one another, seeing that you have put off the old nature with its practices
Colossians 3:10 and have put on the new nature, which is being renewed in knowledge after the image of its creator.
Colossians 3:11 Here there cannot be Greek and Jew, circumcised and uncircumcised, barbarian, Scyth'ian, slave, free man, but Christ is all, and in all.
Colossians 3:12 Put on then, as God's chosen ones, holy and beloved, compassion, kindness, lowliness, meekness, and patience,
Colossians 3:13 forbearing one another and, if one has a complaint against another, forgiving each other; as the Lord has forgiven you, so you also must forgive.
Colossians 3:14 And above all these put on love, which binds everything together in perfect harmony.
Colossians 3:15 And let the peace of Christ rule in your hearts, to which indeed you were called in the one body. And be thankful.
Colossians 3:16 Let the word of Christ dwell in you richly, teach and admonish one another in all wisdom, and sing psalms and hymns and spiritual songs with thankfulness in your hearts to God.
Colossians 3:17 And whatever you do, in word or deed, do everything in the name of the Lord Jesus, giving thanks to God the Father through him.
Colossians 3:18 Wives, be subject to your husbands, as is fitting in the Lord.
Colossians 3:19 Husbands, love your wives, and do not be harsh with them.
Colossians 3:20 Children, obey your parents in everything, for this pleases the Lord.
Colossians 3:21 Fathers, do not provoke your children, lest they become discouraged.
Colossians 3:22 Slaves, obey in everything those who are your earthly masters, not with eyeservice, as men-pleasers, but in singleness of heart, fearing the Lord.
Colossians 3:23 Whatever your task, work heartily, as serving the Lord and not men,
Colossians 3:24 knowing that from the Lord you will receive the inheritance as your reward; you are serving the Lord Christ.
Colossians 3:25 For the wrongdoer will be paid back for the wrong he has done, and there is no partiality.


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Rockford, IL -- The Beloit College Men's Soccer team took a break from Midwest Conference play but didn't give Rockford College much of a break in a 6-0 win on Wednesday.
Marc Robinson scored three goals to lead the Bucs. Aaron Clark, Philip Amsden and Alexander Carnes also scored. Jackson Wilkins, Ryan Munger, Isaiah Turner-Wyatt and Julian Baker added assists.
Robinson scored his first two goals in a two-minute span of the opening half to stake the Buccaneers to a 2-0 lead at the break. Clark scored his goal two minutes into the second half before Robinson completed his hat trick on a penalty kick at the 53:05 mark.
BJ Kiser made three saves in net for the win. Soshi Mizutani shared the shutout with Kiser, playing the final 17 minutes in goal.
Beloit is back in action on Saturday afternoon when they host Grinnell College at the Strong Complex Field. Kickoff is set for 1:30 p.m.


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|Print Page
HELPER - Pete Via, passed away Aug. 29, 2012 at his home while surrounded by his loving family.
Funeral Mass will be held on Saturday, Sept. 1, 2012, 10 a.m., at St. Anthony Catholic Church in Helper.
Vigil Service Friday evening 7 p.m. at the church in Helper. The family will be at the church Friday and Saturday one hour prior to services. Arrangements entrusted to Mitchell Funeral Home where friends may share memories of Pete at www.mitchellfuneralhome.net.
|Print Page


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Audible: Dowhatchyalike
Brian Bassett , TheJetsBlog.com
I had no delusions about this game, but a beatdown like that gets me philosophical. Real ontological ish.
Why do I take time every day to write about this dreadful team? Why does this organization hate me so much to put me through this? Does the coaching staff think I have the IQ of a candied yam to keep playing Mark Sanchezand say he gives the team the best chance? I don't even care about chances anymore and neither should the Jets, but why does any of this even matter? Is my existence and the Jets suckiness eternal since they both originate from nothing?
I'm done for the day. I'm going to enjoy time with my family and not agonize over a terrible football team.
So in the immortal words of Digital Underground, dowhatchyalike …


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U.S. State Highpoints > Mount Greylock > Climber's Log
Mount Greylock Climber's Log
[ Sign the Climber's Log ]
|Route Climbed: Roaring Brook - Hopper Trail Date Climbed: October 9 2004
|Ended a 7 peaks in 8 days trip
|Posted Oct 9, 2004 8:03 pm
|Route Climbed: AT Date Climbed: 9-20-98
|Knocking off State High Points and sections of the AT in a single swoop! Can't get better then that.
|Posted Sep 9, 2004 2:46 pm
|Route Climbed: Hopper trail both times Date Climbed: July 1999 and January 2001
|Hot and muggy in the summer, freezing and snowy in the winter...nice trail up and down, few people on this trail, great views both summer and winter--expect high winds in winter and bring snowshoes!!
|Posted Jul 31, 2004 3:40 pm
|Route Climbed: Cheshire Harbor Trail Date Climbed: 5/29/04
|If you are a 48 or 50 completer with highpoints, you should be required to hike this. If you can climb Denali, you can climb Greylock! Nice views, though the summit was way to big and the lookout tower sucks.
|Posted May 31, 2004 3:30 pm
|Route Climbed: Haley Farm Trail Date Climbed: January 2, 2004
|My first state highpoint. Snowshoed part of the way even though it was mostly ice covered by a miniscule amount of fresh snow. Once on the road we slipped around quite a bit and used the snowshoes to act as crampons. We probably looked ridiculous. Nice to be here in the winter cause we didn't see one other person on the peak, but the famed views of 5 states wasn't much more than a lot of gray fog.
|Posted Apr 23, 2004 3:37 am
|Route Climbed: west side Date Climbed: 07/03/97
|Lots of people! I hate mountains with roads to top!!!!!!!!!!
|Posted Nov 26, 2003 10:52 am
|Route Climbed: thunderbolt! Date Climbed: september 21 20000
|Lots of cars and people on the summit.
|Posted Sep 27, 2003 10:49 am
|Date Climbed: July 28, 2002
|Bagged this state highpoint as a drive up, at 11:00 PM. Mountain was completely fogged-in. It was a challenge staying on the road up to the summit, even at 5 mph.
|Posted Sep 19, 2003 12:18 pm
|Route Climbed: AT Date Climbed: Easter Weekend 1999
|Climbed this with my sons, a friend named Dan and my dog. We were told by day hikers on Saturday that the temperature dropped to 15 degrees on the mountain Friday night. It was a rough night sleeping.
|Posted Aug 18, 2003 8:24 pm
|Route Climbed: can' remember but it was from the East Date Climbed: June 10, 2001
|A nice easy climb. the bugs were not too bad and the views from the top were fairly good, but other peaks in the Northeast have more of a backcountry feel.
|Posted Apr 26, 2003 2:44 pm
|Route Climbed: AT
Date Climbed: May 27, 2000
|Hit this on my 2000 AT thruhike and chatted up some motorcycle climbers reading the AT plaque. They'll have some good stories of the dirty backpacker they met.
|Posted Mar 3, 2003 6:42 pm
|Route Climbed: AT from Adams Date Climbed: Summer 1996
|Pleasant enough hike, but sucks being on a mountain where 99% of the people drove to the top.
|Posted Aug 15, 2002 12:16 pm
|Weekend Warrior
|Route Climbed: Appalachian Trail - Notch Rd in Cheshire to summit Date Climbed: June 2001
|Trip was moderate for the most part. Northern section of AT heading south over Mts. Williams, Fitch & Greylock was much steeper and energy consuming. Trail northbound seemed longer (9 mi one way), but much easier on the feet. Limited views until nearing summit area. Still a godd mountain to start the hiking season off with.
|Posted Aug 10, 2002 2:40 am
|Route Climbed: From Thunderbolt Lodge ;-) Date Climbed: July 8, 2002
|Impressive views from the summit east down to the valley and of the summit (and Hopper Valley) from Stony Ledge. Made the visit with my parents and 94 year old grandmother ;-)
The Thunderbolt Lodge (1 room), refurbished in 1998, is surprisingly plush and looks like a great place to spend some time during the winter. There's even a fully stocked wood shed for use with the 4 wood stoves. Although you are not supposed to spend the night in there except for emergencies, it seems like it would be a lot of fun!
I came here once before on Dec 24, 2001 and attempted to hike up the gated (closed) 9 mile road but got very bored of walking through 1-2 inches of slush with 100' visibility so turned around about 4 miles up. I saw 2 x-country skiers and think that x-country skiing or mountain biking would be more fun during the winter if you want to take the closed road. Snowmobiles also seemed to be a popular method up from the tracks I saw. They also got a surpise 10 inches of snow on May 18, 2002 that temporarily closed the road to the summit. My 6th state highpoint after: NH, TN, NC, OR, and CA. Highpointing really isn't a priority for me but it's still fun :-)
|Posted Jul 9, 2002 9:17 am
|Route Climbed: Appalachian Trail in 1995, don't remember in 1994 Date Climbed: July 1994, and July 1995
|Interesting little mountain in the scenic Berkshires. I bagged this state highpoint as a day-hike in 1994 and again during my Appalachian Trail thru-hike in 1995.
|Posted Aug 21, 2001 10:24 pm


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Windproof merino hoody as worn by Team Sky
An innovative, mid-weight outer layer that uses an ingenious mix of fabrics to create a top that offers high performance with contemporary, urban styling.
Windproof front panels keep out chills when riding, while the merino body and arms keep you snug on and off the bike. The jacket also features clever functional details such as a detachable Sky blue tab with reflective Rapha logo and a roll-up hood.
Key features:
- Merino-rich fabric
- Overlaid with windproof fabric on front, sides and shoulders
- Roll-up windproof hood
- Two zipped front pockets
- Team Sky details and logos


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Hitachi Hot Deals
If you are looking for great deals on Hand Tools, Power Tools, Accessories and more, you will find incredible savings in our Hot Deals section. With limited stock available, you may want to act fast before they disappear!
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Hitachi C7ST
7-1/4" Circular SawSale Price: $84.88In Stock
Hitachi's C7ST circular saw is lightweight at only 9.4lbs yet very powerful thanks to the 15amp motor. Max cutting depth on this new model has increased to 2-7/16" at 90°.Learn more about the Hitachi C7ST
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Hitachi DH22PG
7/8" SDS-Plus Rotary HammerSale Price: $75.14In Stock
Hitachi's most compact and lightweight SDS hammer ever, the new DH22PG is ideal for overhead or extended use applications and allows the user to gain access to the tightest areas.Learn more about the Hitachi DH22PG
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Hitachi DS18DVF3
18 Volt Ni-Cad 1/2" Cordless Drill KitSale Price: $99.00In Stock
Get the strength you need and the comfort you want with Hitachi's 18 Volt Ni-Cad 1/2" Cordless Drill Kit (DS18DVF3). The 2-piece magnet motor produces 400 in.-lbs. of torque to pound through the toughest tasks on the job site or at home.Learn more about the Hitachi DS18DVF3
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Hitachi KC18DBFL
18V Lithium Ion Brushless Hammer Drill and Impact Driver Combo KitSale Price: $314.64In Stock
This Hitachi 18V Lithium Ion Brushless Hammer Drill and Impact Driver Combo Kit (KC18DBFL) is the perfect set of tools to take on any heavy duty application. It includes the DV18DBFL 18V Brushless Lithium Ion Hammer Drill and WH18DBFL 18V Brushless Lithium Ion Impact Driver.Learn more about the Hitachi KC18DBFL
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Hitachi NR90ADPR
3-1/2" Paper Collated Clipped Head Strip NailerSale Price: $199.00In Stock
The new NR90ADPR framing nailer fi res paper collated nails from 2" to 3 1/2" in length and features Hitachi's next generation "Industrial Design".Learn more about the Hitachi NR90ADPR
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Moderators: Timko, Solty, Frank Delicious, Blake_T, Fritz, Booter
masterbeato wrote:...900 feet, everybody is happy.
Sean40474 wrote:Just wanted to pop in and say my Kong is still going strong, been around the country with me in wicked weather.
What is the process of sending this back and having some newness added to it. The places where my caribiners connect are tearing through the bag connectors.
dgdave wrote:Where the hell are the pics?
Users browsing this forum: Bing [Bot] and 4 guests


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Do Stock Prices in Turkey Reflect Fundamental Information? A Firm-level Analysis
This paper investigates the correspondence between stock prices and firm fundamentals in Turkey. In pursuing our objective, we explore the relationship between firm-specific variation in stock returns and fundamentals in the context of a simple present value framework. We overcome the typical insufficiency of the spans of time-series accounting data in emerging market research, and the consequent loss of statistical testing power, by adopting a firm-level micro panel data approach. After properly accounting for unobserved heterogeneity, potential endogeneity bias and volatility persistence, we find that firm-specific variation of stock returns in Turkey is only weakly correlated with alternative proxies of firm-specific variation in firm fundamentals and that the relationship is not robust to the influence of control variables such as the firm size. Our findings are, therefore, consistent with the usual perception that stock prices in emerging markets contain little firm-specific information.
This work is licensed under a Creative Commons Attribution 3.0 License.
International Journal of Economics and Finance ISSN 1916-971X (Print) ISSN 1916-9728 (Online)
Copyright © Canadian Center of Science and Education
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"THEY'LL BE IN THE PLAYOFF RACE UNTIL THE END"Scouts' Poll Season Preview, Part 1 – The Standings
There's no question in my mind. The Islanders are competitive again.
This is what one of four NHL pro scouts told Point Blank this week for a preseason poll. Four out of four scouts surveyed were confident the Islanders will contend for a playoff berth in 2011-12.
"They'll be in the playoff race in the East until the end," said another. "I don't see more than five teams running away with playoff positions by the start of March. All of the teams that didn't make the playoffs got better in the offseason. I think this will be a wild playoff race. I wouldn't be surprised if as many as 9 teams were fighting for the final 2 or 3 spots in late March. For the Islanders, it's going to come down to how well their D and goaltending hold up."
That sentiment, of course, was also unanimous among the four NHL pro scouts. These scouts are tasked by their clubs to spend most of their time on the road following the National Hockey League and American Hockey League. They are responsible for filing pre-scout reports for their head coaches and providing guidance to their general managers on trade acquisitions, waiver wire pickups and future free agent signings. All four have followed the Islanders and the Eastern Conference religiously for at least the last three seasons.
To a man, they believe Islanders fans will be engaged in the upcoming regular season from the beginning until the end. "The days of being out of contention way before the All-Star break are finally over," said one.
That said, none of the scouts were prepared – at least in late August – to declare the Islanders a bonafide playoff team.
Summarized one, "I've got three concerns for them: lack of depth and experience – especially on defense – their history of having over 300 man-games lost to injury per season, and the competition in the East. The Islanders are getting better and they will be better, but I don't know if they're good enough to close out one of the playoff spots in the final quarter of the season."
With a key roster upgrade or two, they certainly could. Looking in awe at the Islanders' cap space, the scouts know general manager Garth Snow has the cap flexibility, resources and assets to add a key player when needed.
"Snowy is not done," said one scout. "I know he tried all summer to add a dman, but the (Christian) Ehrhoff thing went bust because they wouldn't give him a blank check up front and he hasn't been able to connect on another deal like he did with Wisniewski last summer. There's still time left. Good players will be available during camp in trades and on the wire. A quality player that an Edmonton might not want to spend for could be snapped up by Snowy."
Said another, "I know for a fact that Garth offered a training camp invite this month to a pretty good veteran, but he turned it down for now. To me, that's a sign Garth is trying to do whatever he can within his limitations. He has to know he needs more if he really wants his team to finally make a big splash this season. It's good for business and it's good for arena negotiations."
Point Blank Take: There's probably little above that the most ardent Islanders follower would disagree with. My biggest concern is the team's lack of depth. The forward corps is strong, but many players still have a lot to prove in crucial game situations. The goaltending rotation is certainly deep and will be a fascinating study from the first day of training camp. The health of the team's current top six on defense has been well-documented here and elsewhere. (An educated guess at the veteran who turned down the camp invitation "for now" – Long Island resident Bryan McCabe).
I expect the Islanders to have a very good start to the season and create some much-needed positive buzz for the franchise after the disappointment of the referendum. The schedule is favorable early and the talent is there. But the long NHL season can be cruel for teams that are not well-stocked at every position. Reality could hit for the Islanders in the second half. There are too many teams in the East with far more consistent goaltending and defense.
Unless the Islanders manage to reverse a trend and limit their man-games lost to injury to under 200, the excitement could very well last into March, but as currently constructed the team is more destined for 10th place than the playoffs. That's if Snow isn't finally able to make his first major impact transaction of 2011.
Still, as the pro scouts have forecasted, it's going to be an exciting season from start to finish. Being in the battle late in the season will show marked improvement. After four years of the slow and steady rebuild, legitimate playoff contention will be welcomed. Important hockey games are back at the Nassau Veterans Memorial Coliseum this season.
In the coming days, Point Blank – with some assistance from our pro scouts – will take a position-by-position look at the Islanders in 2011-12. Your as-of-now thoughts on where the Islanders will rank in the East are welcomed in the Comments thread. Thank you.


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Bruins @ Rangers
Madison Square Garden, 7:00 p.m. Wednesday
Rangers record: 10-7-1
Bruins record: 9-5-1
After the New York Rangers' past two emotionally charged games, the Garden Faithful is bound to have high expectations come Wednesday night's matchup against the Boston Buins.
Marian Gaborik announced his return to the lineup with a hat trick in Sunday's goal blitz, and Henrik Lundqvist reminded everyone why he's still the King with a stupendous 37 save effort last night in the Penguins' brand new arena. The officiating was arguable at best, but the Rangers killed off all six of the Penguins' power plays. Brian Boyle and Brandon Prust continued to spearhead the team's impressive penalty kill, one that has been 95.2% efficient in the past six games, allowing only one goal in this time frame. The Rangers look for a fourth straight win tomorrow night against their competitive division rival, a team which also snagged an important and exciting win last night.
While the Bruins have cooled off since hosting the Rangers at the end of October, they're still a force to be reckoned with. The Bruins snapped a two-game losing streak against the still-slumping New Jersey Devils last night. Tim Thomas, who has been outstanding this season, turned aside all 28 Devils shots to earn his league-leading fourth shutout. Even without centers Marc Savard and David Krejci, both of whom are out with concussions, the Bruins' offense has been on the rise. While second overall draft pick Tyler Seguin hasn't scored a point in his last three games or a goal in his past seven, longtime Bruins Mark Recchi and Milan Lucic have been very solid offensively. Nathan Horton is doing exactly what he was brought up from Florida to do, and he currently leads the team with eight goals and fourteen points. Michael Ryder, a former thirty goal scorer, has performed very well this season, too, and he scored the Bruins' first and eventual game winning goal in Monday night's contest.
Defenseman Johnny Boychuk may return to the Bruins' lineup on Wednesday after missing nine games with a broken wrist sustained in the last matchup of these two teams, after a slash by Brandon Dubinsky. Stung by the loss of Boychuk, the Bruins will certainly have their eye on Dubinsky tomorrow evening; but based on Dubinsky's play this season and his stunning performance in the 3-2 overtime win against the Penguins, they will certainly need to keep Dubinsky in mind for other reasons as well.
As usual, the Bruins and the Rangers match up pretty evenly. In the standings, both teams sit in second in their respective divisions. Offensively, both teams are averaging around three goals per game, and both teams are fresh off exciting (and bloody) wins on Monday night. In the past, Bruins-Rangers matchups have generally been low-scoring but tantalizing, with a one or two goal differential sealing the deal for the winning team. With two hot goalies in net tomorrow—Tim Thomas, with a league-high .960 save percentage, and Henrik Lundqvist, coming off a thrilling performance in Pittsburgh—the game is destined to be the competitive nail-biter we've come to expect from these two teams.
The donning of the Ranger's third jerseys—dubbed the "Heritage" jersey—will add extra significance to the upcoming game. Win or lose, the (navy-tinted) Blueshirts' overall play and spirit as of late has been admirable, and we can expect this team to wear their new jerseys with pride.


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"Candy Lane" greeting card by Brenda Bryant. Ships within 2 - 3 business days and includes a plain white envelop for mailing and/or gift giving. Available in vertical and horizontal orientations.
Welcome to my galleries. I painted exclusively in the 80's, then later fell in love with photography. After many years of doing portraits of families, children, seniors and weddings, I finally slowed down and started challenging myself to look at things around me differently. I will always love photography, but I am rediscovering painting as well. My galleries will include both..I am simply an artist at heart and always will be. Please feel free to send me a message if you need a different size uploaded or have any questions. My work here is for sale and I will be happy to help you in any way. FAA does an excellent job of custom printing and framing. I hope you enjoy my galleries and your comments are always welcome.
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By BOB POTTSContributor
The Carbon Volleyball team will hold its annual Blue/White Game on Thursday August 20 in the Carbon High Gym at 6:00 pm. This is a chance for the public to meet the coaches and players for the upcoming season.
Coaching staff consists of Varsity Coach Bob Potts, JV Coach Mariana Becheli, Sophomore/Freshmen and Coach Randilyn Leonard.
The team has four seniors this year and all play key roles. Middle hitter Joy Malone averaged 3.14 kills a game last year.
She will be attacking the ball hard again this year. Malone should average four plus kills a game this season and is fun to watch as she loves to hit the slide. Shaylee Donathan is taking over the setting duties and has plenty of offense players to dish out assists to. If the passing is good, she may be one of the top assists leaders in the region.
Melinda Molinar has moved from the middle hitter position last year to the opposite outside hitter this year.
The team will count on her blocking outside hitters from opposing teams and quick offensive hitting. Rounding out the seniors is Sam Olson who loves to hit from the back row and has a downright mean serve.
She is a defensive specialist and will be counted on for defensive digs that really keep play alive for the team when things get tough.
This year's team will also have another powerful outside hitter in junior Tia Pappas. She led the JV last year in kills per game and puts the ball down.
Alexis Oliver, another junior, has moved from setter to Libero and will be the back row captain as she moves on and off of the floor.
She is very athletic and at times seems to be flying through the air making sure no ball hits the ground. Her passing skills are a great example for any younger player to learn from.
Juniors Sara Potts and Mariah Pollock will also play big roles in the outside hitting duties. Sophomore Miranda Averett plays the second middle hitter position and beside good height also posses great speed.


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A brilliantly chilled out login screen. I particularly like how the design draws your eye to the centre and the consistent use of colour. The simple login boxes and restrained use of text make for a great user experience.Posted in Interface → Web App
An interesting winged logo design that makes brilliant use of texture! I love the contrast of natural ideas (like wings) with more mechanical ones (like cogs). The colour palette is subtle but works excellently, particularly over this kind of textured background.Posted in Branding → Logo
It's always delightful to see a beautifully designed log in page, it immediately gives you a idea of the depth of commitment the company has to good design. I love how uncluttered this log in page is and the satisfying 'Sign In' button.Posted in Interface → Web App
A gorgeous logo for any music based design company. I love the concept of the vinyl record breaking into streams of paint-like colour! In addition it\'s worth noting how good the flow of the logo is, it works beautifully read from left to right!Posted in Branding → Logo
An absolutely stunning site for Skigo, a company which aims to help support people in the creative industries. I love the minimal design and truly ingenious use of colour! It's rare to find a site that's enjoyable to play with and intriguing to investigate.Posted in Web Design → Misc
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A beautiful and effortlessly minimal site that allows this designer's work to make an immediate impact. I love the subtle use of colour and restrained use of text. The gallery section really draws you in and gets you straight to the point.Posted in Web Design → Design
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An intriguing site for a designer who focuses on \'typographically sound\' design. It\'s interesting that it\'s so stripped back and minimal and simply includes a shot from his latest project rather than a gallery. I do, however, like the focal slideshow and the beautiful graphical detail on each slide.Posted in Web Design → Design
As probably the foremost Twitter client (if you ignore Twitter\'s own client) TweetDeck has a lot of weight on its shoulders. It certainly lives up to the hype with its gorgeous interface designed specifically for the iPad. I love the logo and stylish grey colour scheme!Posted in Interface → iPad App
An awesome site for professional windsurfer Sean O'Brien. I love the graphic design ideas and how it all fits in a single window with no scrolling! The simple drop down navigation bar is a nice touch, as is the detailing on the logo!Posted in →
An incredibly bright and vibrant design for a business card! The colour is striking and immediately grabs your attention. The eye logo works really well as the focal point and is made even more effective by using white on such a bright background colour.Posted in Branding → Business Cards
A bright and immediately striking site for a web design agency. The use of yellow as a focal colour works very effectively! The use of typeface really helps to engage visitors, but some of the sizing of the text further down the page, while obviously intended to highlight certain things, is a little distracting.Posted in Web Design → Design
A fascinating way to experience the weather on your iPad. I love the heat imagery and sheer amount of information that is available from a single window. I particularly like the design of the sidebar, it\'s effortlessly functional and looks just great!Posted in Interface → iPad App
A clean and intuitive site for a graphic designer and frontend web developer. It\'s a good example of effective selection of typefaces, the name of the site is interesting and made a focal point while the main text is in a more clearly readable typeface. I particularly like the portfolio gallery and the differently sized thumbnails of each project!Posted in Web Design → Design
FlickStackr is an excellent way to browse Flickr on your iPad! The icon design is good which always helps to make the overall experience enjoyable. The use of thumbnails throughout is good and allows the wealth of Flickr photography to shine through!Posted in Interface → iPad App
A fascinating business card design that makes great use of some intriguing art. The designs make an immediate impact, you can\'t fail to be interested! I also particularly like how this card is displayed on some rustic wooden floorboards.Posted in Branding → Business Cards
Sometimes designing a great interface is more about what you leave out. Simplenote is a superb example of a consistently minimal approach to interface design! It\'s intuitive, clear, and just \'works\'!Posted in Interface → iPhone App
An elegant solution for using Dribbble on your iPad. I love that it gives over almost 100% of the space to design work and keeps the interface elements out of the way! The gallery looks awesome in simple grey shades and really allows the designs to take centre stage.Posted in Interface → iPad App
An awesome example of a genuine looking logo stamp. The dark red colour works really well in contrast to the light background. The textured background really helps this logo design to pop!Posted in Branding → Logo


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Torrentshell Trench Coat (Women's) Closeout (out-of-stock)
Out of Stock Product Number: 32156
The women's Torrentshell Trench Coat by Patagonia is built for harsh conditions. However, this elegant, urban trench coat is made of lightweight nylon with a waterproof/breathable H2No barrier.
This hardy yet polished trench coat keeps you dry in all-day drizzles and downpours. Made of a waterproof/breathable H2No 2.5-layer nylon ripstop fabric, it has an interior surface texture that channels moisture away from the skin. The lightweight and highly compressible coat stuffs handily into purse or pack. Weather-proofing details include an adjustable, removable hood that secures with hidden snaps and a full-length snapped placket complete with 2-way zipper and storm flap. Articulated elbows allow freedom of movement; cuff tabs have 2-position snaps. Princess seaming and elasticized waist at the back create a feminine silhouette. Pockets: two front drop-ins with snaps and a zippered interior mesh. Above-the-knee length.
* This product does not qualify for shipping to all countries.
- H2No Performance Standard 2.5-layer tear-resistant fabric is packable and lightweight; interior surface design channels moisture away from skin, slides easily over layers and protects the waterproof/breathable barrier from abrasion
- Removable hood has adjustable drawcord and secures with hidden snaps
- Full-length snapped placket with 2-way zipper and storm flap
- Articulated elbows; 2-position, snapped cuff tabs
- Pockets: two patch pockets with flaps secure with hidden snaps; side-entry handwarmers lined with brushed polyester
- Front and back princess seaming with darts provide a feminine silhouette; removable belt and closed back pleat
- Above-the-knee length
- H2No Performance Standard shell: 2.5-layer, 2.6-oz 50-denier 100% nylon ripstop with a waterproof/breathable barrier and a DWR (durable water repellent) finish
Gender: Women's
Weight: (10.4 oz) 295 g
Material: 2.5L H2No Performance , Deluge DWR
Fit: Above-the-knee length, Regular fit
Technologies: [H2No]
Season: F12
Vendor ProductId: 27195
Review ProductId: 24537
Reviewed by 1 customer
- Breathable
- Comfortable
- Lightweight
- Stylish
- Waterproof
- Not Windproof
Best Uses
- Casual Wear
- Wet Weather
Comments about Patagonia Torrentshell Trench Coat (Women's) New:
I like the stylishness of Patagonia jackets, but their sleeve length is always too long and I don't think I have short arms. I don't have that problem with other brands.
- Fit:
- Feels true to size
- Sleeve Length:
- Feels too long
- Chest Size:
- Feels true to size
- Was this a gift?:
- No


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Reviewer: Chika Madu, MD
Abramson Cancer Center of the University of Pennsylvania
Last Modified: October 18, 2005
Presenter: L.B. Marks
Presenter's Affiliation: Radiation Oncology, Duke University Medical Center, Durham, NC
Type of Session: Scientific
One of the side effects of lung irradiation is radiation pneumonitis, which can be manifested as dyspnea. However, dyspnea can be one of the presenting symptoms of cardiac disease and might cause confusion in diagnosis following lung irradiation. The purpose of this study was to evaluate the association between heart and lung doses, tumor location, with the development of heart/lung toxicity following irradiation.
Materials and Methods
Author's Conclusions
Clinical/Scientific Implications
This paper addresses one of the very common problems seen in patients who are status post lung irradiation. In patients presenting with dyspnea, it is difficult in certain cases to separate lung from heart etiologies. This study has looked at the MHD received from radiation and has found no correlation with dyspnea, although there is a correlation between MHD and heart toxicities such as pericarditis, myocardial infarction. As such, RT-induced toxicity is more likely to present with symptoms other than dyspnea according to this study. This study did not look at patient hemoglobin levels to evaluate for any correlations. Previous mouse/rat studies have shown a higher incidence of radiation pneumonitis after irradiation to lower lobe tumors. This has also been shown in human studies. What is unclear is why this is the case. Is this due to an intrinsic higher sensitivity of the basal lung to radiation or is it because the lower lobes are larger and more relied upon for respiration? Further studies are needed to clarify this issue. In the mean time, all patients should undergo a complete clinical/laboratory work-up if there is any doubt regarding the etiology of their dyspnea following lung irradiation.


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Video: Gone In 60fps – Making A Site Jank-Free
Introduction What's stopping your web pages from getting silky smooth scrolling, buttery animation and a user experience that's snappy and fast? Jank-free rendering performance has been shown to positively affect user engagement and experience in many large sites, but remains … Continue reading →
My name is Addy Osmani. I'm an engineer at Google working with the Chrome team to build tools to help improve developer productivity and satisfaction.
I've also written 'Developing Backbone.js Applications' and 'Learning JavaScript Design Patterns'.
First do it, then do it right, then do it better. This is one fundamental I always keep in mind when developing anything.
If you're a developer wishing to learn something new, regardless of skill-level, remember that as important as it is to read, it's equally as important to get out there and *do*.
Create a new gist or JSBin, pop open the console and experiment. It's effing fun.


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SOUTH PORTLAND, Maine (NEWS CENTER) -- In the days since the Boston Marathon, many people have been looking for a way to help those affected by the bombings.
Several Mainers said they found a way to help -- in the Maine Mall parking lot.
The American Red Cross held a blood drive at the mall Thursday.
The drive was scheduled well before the Boston Marathon, and it was not a blood drive for Boston hospitals -- but some donors said it was a way to help and show support.
"With all that's going on in the world, to do something like this, real quick and easy -- it's simple to help somebody else out," said Justin Graffam as he donated blood Thursday afternoon.
One of the first people in line to donate was a woman who ran the marathon on Monday.
"Any little thing you can do, kind of helps to ease your own pain," said Nancy Goldstein.
She said she was running at mile 25 when the explosions happened at mile 26. Her husband, who has EMT training, offered medical assistance to those injured by the bombings.
"The events were indescribable, and not anything anyone should live through," said Goldstein.
While her husband was helping the injured, Nancy was getting help from strangers. She said one man offered her the jacket off his back, another helped her text family members to say she was safe.
At the same time, their daughter, Nicole was at home -- feeling helpless.
"Not being able to talk to anyone...not knowing what was happening," said Nicole, "at least today I was able to feel like I was doing something."
Nancy and Nicole encouraged people to contact their local Red Cross office to find out ways to help those affected by the Boston bombings if they could not donate blood Thursday.
More information can be found by calling 1-800-RED CROSS.


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For $109 per night, escape to downtown San Diego -- including weekends and holidays -- when comparable hotels are running up to $230 per night.
Stay at the Four Points by Sheraton Downtown San Diego through Dec. 26.
The hotel is located on the edge of Little Italy, a five minute drive from Balboa Park, the Gaslamp Quarter and San Diego Zoo.
For more hotel information, click here.
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Pharmacokinetics and Tolerability of Zavesca® (Miglustat) In Patients With Juvenile GM2 Gangliosidosis
Recruitment status was Active, not recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of the study is to investigate the pharmacokinetics of Zavesca (miglustat, OGT918) when given as single and multiple doses in juvenile patients with GM2 gangliosidosis.
Gangliosidoses GM2
Drug: miglustat
Phase 2
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Pharmacokinetics and Tolerability of Zavesca® (Miglustat) In Patients With Juvenile GM2 Gangliosidosis: Single and Multiple Oral Doses
- Concentration of miglustat in plasma [ Time Frame: Periodic intervals up to 24 hours ] [ Designated as safety issue: No ]
- Changes in volume loss and signal intensity from baseline MRI [ Time Frame: 12 months ] [ Designated as safety issue: No ]
- Change in single-voxel N acetylaspartate (NAA) from baseline MRS [ Time Frame: 1 month, 3 months, 6 months, 9 months, and 12 months ] [ Designated as safety issue: No ]
- Change in neuropsychological testing from baseline [ Time Frame: 6 months and 12 months ] [ Designated as safety issue: No ]
- Change in nerve conduction [ Time Frame: 6 months and 12 months ] [ Designated as safety issue: No ]
- Change in neurological examination from baseline [ Time Frame: 1 month, 3 months, 6 months, 9 months, and 12 months ] [ Designated as safety issue: No ]
|Estimated Enrollment:
|Study Start Date:
|July 2004
|Estimated Study Completion Date:
|October 2006
|Assigned Interventions
|Experimental: 1
Drug: miglustat
Target dose of 320 mg/m^2/day (divided in 3 doses) will be based on the Body Surface Area (BSA). For children with a BSA > 1.3, 200 mg TID will be administered. For children with a BSA of 0.8-1.3, 100 mg TID will be administered.
Other Name: Zavesca
Detailed Description:
The GM2 gangliosidoses are a group of neuro-degenerative lysosomal storage diseases resulting from accumulation of GM2 and related glycolipids in the central nervous system (CNS). Tay-Sachs and Sandhoff disease are two variants which are indistinguishable in clinical grounds. According to the onset and rate of disease progression, the condition can be categorized in infantile, juvenile and adult forms. This open-label, single-arm study is designed to assess the pharmacokinetics, safety and tolerability of miglustat in juvenile patients. Miglustat will be administered at a maximum dose of 600 mg/day, divided into three doses per day. The dose used for patients in this pediatric age range will be related to the patient's body surface area. The pharmacokinetics assessments for the study will be performed in-hospital during a 24 hour period, and will take place at the day one and at the month 3 visits. The clinical (which includes safety and tolerability) assessments will be performed throughout the 24-month study period.
|Ages Eligible for Study:
|6 Years to 20 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Diagnosis of GM2 gangliosidosis confirmed by demonstration of profound deficiency of β-hexosaminidase A or A & B in peripheral blood leukocytes or cultured skin fibroblasts
- Aged 6 to 20 years
- Onset of characteristic clinical symptoms of the disease before age 15 years
- Normal renal or hepatic function
Exclusion Criteria:
- Fertile patients who do not agree to use adequate contraception throughout the study and for 3 months after cessation of miglustat treatment.
- Patients who cannot tolerate the study procedures, cannot be compliant to therapy or who are unable to travel to the study center as required by this protocol.
- Patients receiving other investigational agents within 3 months of study initiation.
- Patients with disease that may affect absorption or elimination of drugs.
- Patients suffering from clinically significant diarrhea (>3 liquid stools per day for > 7 days) without definable cause within 3 months of baseline visit, or who have a history of significant gastrointestinal disorders.
- Patients with swallowing difficulties.
- Patients with a high probability of dying during the study.
- Patients who in the opinion of the investigator (for whatever reason) are thought to be unsuitable for the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00418847
|Canada, Ontario
|The Hospital for Sick Children
|Toronto, Ontario, Canada, M5G 1X8
|Principal Investigator:
|Joe TR Clarke, MD
|The Hospital for Sick Children, Toronto Canada
No publications provided
|Responsible Party:
|Joe Clarke/Principal Investigator, The Hospital for Sick Children
|ClinicalTrials.gov Identifier:
|NCT00418847 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 4, 2007
|Last Updated:
|March 11, 2010
|Health Authority:
|Canada: Health Canada
Keywords provided by The Hospital for Sick Children:
lysosomal storage diseases
Gangliosidoses GM2
Tay-Sachs disease
Sandhoff disease
Infantile GM2-activator deficiency
Additional relevant MeSH terms:
Gangliosidoses, GM2
Tay-Sachs Disease
Brain Diseases
Brain Diseases, Metabolic
Brain Diseases, Metabolic, Inborn
Central Nervous System Diseases
Genetic Diseases, Inborn
Lipid Metabolism Disorders
Lipid Metabolism, Inborn Errors
Lysosomal Storage Diseases
Lysosomal Storage Diseases, Nervous System
Metabolic Diseases
Metabolism, Inborn Errors
Nervous System Diseases
Anti-HIV Agents
Anti-Infective Agents
Anti-Retroviral Agents
Antiviral Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Therapeutic Uses
ClinicalTrials.gov processed this record on October 09, 2015


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Nelson Mandela
South Africans fix a sign wishing well former South African president... News PhotoFormer,Horizontal,Hospital,Human Interest,Looking,Nelson Mandela,People,President,Pretoria,Repairing,Security Guard,South Africa,WishingPhotographer ALEXANDER JOECollection: AFP 2013 AFPSouth Africans fix a sign wishing well former South African president Nelson Mandela on June 25, 2013 to a fence as a security guard looks on, outside of the Mediclinic heart hospital in Pretoria where Mandela is receiving treatment. Mandela's close family gathered today at his rural homestead to discuss the failing health of the South African anti-apartheid icon who was fighting for his life in hospital. Messages of support poured in from around the world for the Nobel Peace Prize winner, who spent 27 years behind bars for his struggle under white minority rule and went on to become South Africa's first black president. AFP PHOTO / ALEXANDER JOE (Photo credit should read ALEXANDER JOE/AFP/Getty Images)


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Beaded Acrylic Chandelier Garland
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Was very pleased with this garland for the variety in the strand. Ordering some more.
Chrystal hanging beads.
I was very pleased with the beads. It was exactly what I was looking. The merchandise arrived without a problem. I would definitely order from you again. Thank you.
a little bling
We ordered these to hang from sliver glitter branches we looked everyplace and could not find any that had as much detail and different shapes.
These worked great for my centerpieces! I just took them apart at the rings to make a few smaller pieces.


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Call Now:1-800-435-4074
Tomatoes, onions and bell peppers add savory flavor to this tender, fluffy omelet. Cheddar and Monterey jack cheeses and a blend of fire grilled fajita spices kick this protein-packed breakfast up a few notches—perfect for a warm, hearty alternative to breakfast cereal that's ready in just three minutes.
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Short Sleeve Quest Crewe (Men's)
Out of Stock Product Number: 31770
The men's Icebreaker Short Sleeve Quest Crewe is made from lightweight GT150 fabric for running, gym workouts and other high aerobic activities. Eyelet panels add extra ventilation, and raglan sleeves give extra freedom of movement. The back pocket has storage for keys, gels and an MP3 player - there's a loophole for the headphones. Icebreaker GT is our technical performance range for running, mountain biking, fitness and other high intensity sports. Made with a little LYCRA� for a perfect fit, these styles regulate temperature, breathe to prevent overheating, dry fast and resist odour.
* This product does not qualify for shipping to all countries.
- The workout crew as agile as you
- Fast drying and odour resistant
- MP3 tunes via cord loophole
- Eyelet panels Increase venting
- Back stash pocket for keys/gels
Gender: Men's
Fit: x
Season: F12
Vendor ProductId: IB5E77
Review ProductId: 31770


text: Getty Images [ Game Shoots Wedding Reality Show, Coolio's Son Pleads Guilty to Felony, Usher to Settle Custody Battle & More By Theo Bark July 16, 2012 It's "Too Hot" for Coolio's son, Grtis Ivey, 22, who has pleaded guilty to a felony robbery charge, and is headed to prison for 3.5 - 10 years, after he and a prostitute friend robbed a man at gunpoint in Las Vegas... Read More Category: Hip-Hop, R&B Tags: Action Bronson, ActionBronson, Alchemist, Coolio, coolio grtis, coolio son, coolio son jail, CoolioGrtis, CoolioSon, CoolioSonJail, Drake, Earl Sweatshirt, EarlSweatshirt, Game, Game vh1, GameVh1, lord finesse, LordFinesse, Mac Miller, MacMiller, Odd Future, OddFuture, Public Enemy, PublicEnemy, Sean P, SeanP, Usher, usher custody, UsherCustody Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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APN: 01-1810-0232 Trust No. 1315528-07 Ref: Jayme Mcdonald TRA: Loan
No. xxxxxx7691. IMPORTANT NOTICE TO PROPERTY OWNER: YOU ARE IN DEFAULT
UNDER A DEED OF TRUST, DATED March 14, 2006. UNLESS YOU TAKE ACTION TO
EXPLANATION OF THIS PROCEEDING, YOU SHOULD CONTACT A LAWYER. On May
31, 2011, at 11:00am, James H. Woodall, as duly appointed Trustee
under a Deed of Trust recorded March 21, 2006, as Instrument No.
116351, in Book 614, Page 649, of the Official Records in the office
at the County Recorder of Carbon County, State of Utah, executed by
Josh Mcdonald, will sell at public auction to highest bidder, payable
in lawful money of the United States at the time of sale. Successful
bidders must tender a deposit of $5,000 in certified funds to the
trustee at the time of sale, with the balance due by noon the
following business day, at the office of the Trustee. At the main
entrance of the carbon county district court 119 E. 100 S. Price Utah
all right, title and interest conveyed to and now held by it under
said Deed of Trust in the property situated in said County and State
described as: Lot 232, cedar hills plat "b", according to the official
plat thereof, filed april 29, 1976 in book 3 of plats at page 151. The
street address and other common designation of the real property
described above is purported to be: 1369 Scenic View Lane (a.k.a; 1369
East Scenic View Lane) Price Ut 84501. Estimated Total Debt as of
May 31, 2011 is $148,581.22. The undersigned Trustee disclaims any
liability for any incorrectness of the street address and other common
designation, if any, shown herein. Said sale will be made without
covenant or warranty, express or implied, regarding title, possession,
condition or encumbrances, including fees, charges and expenses of the
Trustee and of the trusts created by said Deed of Trust, to pay the
remaining principal sums of the note(s) secured by said Deed of Trust.
The current beneficiary of the Trust Deed as of the date of this
notice is: The Bank of New York Mellon Trust Company, National
Association Fka The Bank Of New York Trust Company, N.a. As Successor
To Jpmorgan Chase Bank N.a. As Trustee. The record owner of the
property as of the recording of the Notice of Default is/are: Josh
Mcdonald and Jayme Mcdonald. Dated: April 28, 2011. James H. Woodall
10808 River Front Parkway, Suite 175 South Jordan Ut 84095
(801)254-9450 (800)245-1886 (Hotline) Hours: 9:00 A.M. - 5:00 P.M.
Signature/by: James H. Woodall R-377056 04/28/11, 05/05/11, 05/12/11
Published in the Sun Advocate April 28, May 5 and 12, 2011.


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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
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North country ambulance squad officials are arguing that while their staffs quickly respond to medical emergencies, payments for service from insurance companies has become too slow-moving.
Some squads have waited upwards of 90 days or more to receive payment, while at the same time having to pay staff, order equipment and service vehicles. As a result, some squads are in dire financial straits.
The town of Watertown Ambulance, for example, is considering getting a line of credit to ensure its company bills and employees are paid.
If you lose your job, you pinch your pennies, said David C. Roof, ambulance squad president. Hopefully it wont affect our employees. Its a tough industry.
Medicare, Medicaid and other insurance plans may pay a portion, or all, of a bill, but when squads have to wait a few months for payment their ability to continue service is shaken, Mr. Roof said.
What insurance companies dont cover, patients must pick up. Many patients do not pay that remaining balance.
At the Ogdensburg Volunteer Rescue Squad, Medicare and Medicaid recipients account for 56 percent of its calls. Director of Operations Kenneth J. Gardner said that their reimbursement rates, as well as that of private insurers, are down by 5 percent over the past two years. He sees a trend brought on by economic hard times.
We have no control over what we get, he said.
A trip to a Syracuse hospital costs the squad about $1,000. Medicare and Medicaid reimbursement from that is $300, Mr. Gardner said.
Potsdam Rescue Squad feels the squeeze, too.
Our reimbursements from Medicaid, Medicare and private insurers are most definitely declining, said Karen Mousaw, the squads administrative assistant. About 35 percent of our patients are insured through Medicare and 25 percent have Medicaid.
She said the emergency care environment has dramatically changed throughout the last 58 years, with a long road of regulations, unfunded mandates and minimum requirements ahead of every emergency service agency.
Potsdam Rescue has not been immune to these changes and their financial impact, she said. We rely on contracts with the towns and villages, donations, grants and fundraisers to help close the gap in order to continue providing care to those who need it.
Although ambulance squad officials say donations from community members and proceeds from chicken barbecues and other fundraisers help defray operation costs, shrinking the payment delay time will be highly beneficial.
Staff writer Brian Kidwell contributed to this report.
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The combination of MR imaging and mammography can provide a cost-effective way of improving life expectancy for women who have an increased risk of breast cancer, according to a study authored by Mass General Imaging radiologist Janie M Lee.
Screening with mammography and breast MRI effective for women with high cancer risk
"For women at the highest risk of breast cancer, using both breast MRI and mammography together for screening will likely reduce their chances of dying from breast cancer and help them live longer, healthier lives," said Lee.
Source: HealthImaging.com
U.S. News & World Report ranks Mass General the #1 hospital in America based on our quality of care, patient safety and reputation in 16 different specialties. Learn more about why we're #1
Search the archive for previously published news articles, press releases and publications.
Departments and Centers at Mass General have a reputation for excellence in patient care. View a list of all departments.


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Welcome to Week 35 of our 52 weeks of Sharing Memories - A Genealogy Journey for 2012. I hope you'll join in writing your memoirs and childhood memories for your descendants.
you are just joining us, please take a peek at the last two years of
prompts by clicking on the Sharing Memories tab at the top of Olive Tree
Genealogy blog. You can jump in at any time and you can skip topics
that you don't like. There are no rules, it's all about getting your
memories down on paper. The prompts are here as a guide to help if you
are stuck for ideas.
Share your memories here in the
comment section, on your own blog, or privately in a journal you keep at
home. It is my hope that you will record your memories for future generations.
I loved music. We didn't have a television or record player or radio until I was 9 years old but I loved music from the start. At 11 I asked for my own record player rather than the traditional bicycle that all of my siblings received when they turned 11. Everyone thought I was crazy but I got my record player and spent endless hours of enjoyment in my room listening to my records.
I sang in choirs all through Public School and I have never forgotten my Music Teacher writing on my report card in Grade 6 that I had "...a pleasing alto voice." Funny how a small remark will impact on you for years afterwards.
High school was something I looked forward to because I knew I could join the choir and I could play in a band. I was so excited the first day of music class with our band teacher. I chose drums when asked what instrument I wanted to learn. Imagine my disappointment when I got home and my mother told me I was not allowed to play drums because "it's not a real instrument."
The next day I had to tell my band teacher that I needed a different instrument. All that was left was the French Horn because everyone had already chosen. So I embarked on 5 years of playing French Horn - oompah, oompah, oom pah pah....
If you aren't familiar with French Horns, they play the backup underlying beat. And they fill with spit so you have to keep removing the end bits and dumping spit water out during a performance, otherwise the oompah sound starts to bubble. Gross.
But I did love being in the band despite hating my instrument. And yes I joined the choir and sang in groups and Triple Trios (anyone else remember those?) and enjoyed that too. Since I couldn't stay after school for many practices (because my mother said I had to get a job at the Library after school) I was very lucky to have the choirmaster allow me to stay with the choir.
Did you sing in School Choirs or Church? Did you play in a band? If you did, think of the great stories around that and write them down for your children and grandchildren. They will thank you for it! I recently read my aunt's start of her life story, and was blown away by her telling the story of my mother learning to play the violin when she was 17. My mother never told any of us that she took music classes! It was so interesting to hear because it revealed another side to her.
August 26, 2012
Sharing Memories (Week 35): Music Was Supposed to Soothe My Soul
1 comment:
I'm sorry to hear about your dislike of the French horn. My brother played the horn in high school, and I have several CDs of horn concertos. I love the brass section, and the sounds are so varied among instruments and even with each instrument. I do agree with the valve and mouth piece cleaning. YUCK!
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A look that's perfectly at home in any home, the Aria chair features accommodating comfort and versatile style. Whether used alone or as the perfect complement to many of our La-Z-Boy sofa styles, Aria's sloped rolled arms, decorative wood legs and welted detailing make it a stand-out in any room.
Additional Information
Product image may differ from actual furniture item. La-Z-Boy products are hand crafted and variations from standard dimensions
and appearance can occur. Construction differences in upholstery covering (cloth and leather) can cause variances in dimensions.
Check the standard dimensions listed for the piece you are considering. Note all the numbers for width x depth x height (e.g., 87.5" W x 38" D x 36.5" H). It's also a good idea to consider the diagonal dimensions of the furniture you want. These measurements will be helpful when planning your space.
La-Z-Boy products come with our famous La-Z-Boy limited warranty, one of the best in the industry.
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Reuse and transform your existing applications
IBM® Rational® Host Access Transformation Services (HATS) transforms traditional text-based interfaces—such as 3270 and 5250 green-screen applications—into web, portlet, rich client or mobile device user interfaces. It also extends 3270, 5250 and virtual terminal (VT) applications as standard web services. With Rational HATS, you can easily convert traditional text-based host application screens to user-friendly GUIs.
Rational HATS is available in the following packages: Rational HATS for Multiplatforms and HATS for Linux® on zSeries®, Rational HATS for 5250 Applications on Multiplatforms, and Rational HATS for 5250 Applications on i5/OS®.
Rational HATS allows you to reuse and repurpose your existing assets in innovative ways.
- Terminal applications—transform the user interface of your 3270 and 5250 green-screen applications.
- Web services—extends 3270, 5250 and VT application core business logic as web services or JavaBeans.
- Customization—provides customizable workflow and application navigation.
- Toolkit—provides wizard-based, visual development including visual page design and macro editing.
- Deployments—route applications to IBM WebSphere® Application Server and IBM WebSphere Portal Server, as well as a number of devices and clients.
Terminal applications
- Allows tunable default rendering of all non-customized screens of the application.
- Transforms specific screens using screen customizations and transformations.
- Transforms terminal application components, such as function keys and menu items, into intuitive links, buttons or text with images.
Web services
- Captures screen flows, inputs and outputs with a wizard-based macro recorder. Lets you edit what is captured with the Visual Macro Editor, and creates integration objects and web services from the screen flows.
- Reuses terminal application business logic in new business processes and applications.
- Rational HATS simplifies screen navigation with macros and screen combinations.
- It uses global variables to store data, pre-fill drop-down menus or pop-up windows, and input information for the user.
- Rational HATS can transform a text-based user interface with a rich set of GUI widgets, such as drop-down menus, calendars, tables, pop-up windows and radio buttons.
- Using business logic, Rational HATS augments terminal applications by aggregating terminal application data with other data sources.
- The Rational HATS Toolkit works with a supported Rational integrated development environment (IDE), such as IBM Rational Application Developer for WebSphere Software.
- It provides access to standard Eclipse features such as Java development tools.
- The Toolkit features a wizard-based development process for creating Rational HATS applications.
- Create standard web applications for deployment to WebSphere Application Server.
- Customize portlets with the Rational HATS Toolkit for deployment to WebSphere Portal Server.
- Optimize your web applications for mobile devices running Apple iPhone OS or Microsoft® Windows® Mobile.
- Create a standard Eclipse rich client application for deployment to IBM Lotus® Notes®, Lotus Expeditor or Eclipse Rich Client Platform.
Rational Host Access Transformation Services resources
- Trial software: Rational Host Access Transformation Services Toolkit
Download the Rational Host Access Transformation Services Toolkit for an unlimited time at no cost. Deployment is limited to two runtime connections.
- Data sheet: Rational Host Access Transformation Services (PDF, 284KB)
Learn more about the features and benefits of Rational Host Access Transformation Services.
- Article: Integrate green-screen applications in your SOA: Using Rational Host Access Transformation Services
Discover how Rational HATS can be used easily and non-invasively to develop a web service interface to a host application.
Buy Rational Host Access Transformation Services
Reuse and transform your existing applications
IBM Software Subscription and Support is included in the product price for the first year.
Download software online after purchase - no shipping costs!
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Priority code: Cloud
Rational Host Access Transformation Services resources
- Article: Integrate green-screen applications in your SOA: Using Rational Host Access Transformation Services


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Roxanne Polka Dot Sheath Suit
The Roxanne Polka-Dot Sheath Suit: Bra Sizing with Soft Cups
Roxanne Polka Dot Sheath Suit
The Roxanne Polka-Dot Sheath Suit: Bra Sizing with Soft Cups
Roxanne Polka Dot Sheath Suit 2 2
Great Brand Old fashion brand with new style. Great fit, true to size , feels comfortable on. September 2, 2013
Beautiful vintage look and quality swimsuit I bought the Roxanne Polka Dot Sheath Swim Suit for the vintage look and for the nice sale price. I've been so disillusioned with swim suit quality as of late, that I decided to give this one a try. I was pleasantly surprised! This swim suit is beautiful all around. The cut of the suit is gorgeous, with lovely pleats that lay flat under the bustline. The stretch fabric is thicker than the flimsy kind most swim suits are made of these days. And the fabric was cut perfectly so it stretches appropriately in all the right places and fits snug all around. The inside of the suit is lined with sturdy flesh colored stretch fabric and additional elastic. It is so comfortable and supportive to wear, I'm convinced I feel better when wearing it! The modest leg is very nice for those of us not comfortable in the skimpy swimsuits offered everywhere else. With all this said, I cannot recommend this swimsuit highly enough! It's perfect for any woman who is not too heavy, not too skinny, middle aged, and a mom ; - ) July 29, 2013
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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
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MASSENA - The stars of Impact Wrestling returned to the Massena Arena for the first time since 2011 Friday and were greeted by an enthusiastic crowd that filled the floor seats and much of the bleachers.
Recreation Superintendent Richard A. Boprey said 300 Gold Circle seats, those closest to the ring, were sold out. He estimated the crowd on the floor and in the bleachers at approximately 1,700 fans, who openly shared their feelings about the heels (the bad guys and girls) and the faces (the fan favorites) when the wrestlers entered the ring.
The Gold Circle ticket holders had an opportunity enter the arena early and receive autographs from wrestlers Hernandez, Magnus, Gail Kim, Joseph Park, Matt Morgan and Rockstar Spud.
Before entering the arena, they waited in a line that stretched from the arena door to three-quarters of the way across the parking lot.
It was the first live match Tim Boprey said he had seen. He was in line with his son, Trevor, waiting for the opportunity to meet the stars and watch the action.
I watch it on Thursday nights (on television), Tim said. Its pretty exciting. I like what I see on TV.
He said he been watching wrestling for close to 40 years.
I remember those real old days when they were live on Saturday morning, Tim said.
Given the choice between Impact Wrestling and their competitors, he said he would rather watch the Impact stars.
I like Impact better. It seems a little more real, Tim said.
Trevor said he was looking forward to seeing all the stars, particularly Olympic gold medalist Kurt Angle, who squared off against Bully Ray in a match for the TNA World Heavyweight Champion belt.
Hes like one of the older wrestlers, Trevor said.
Fan Curtis LaHart was at the head of the line, a spot he and his friends had taken at 3:25 p.m. even though the doors wouldnt open until 5:30 p.m.
Like Mr. Boprey and his son, Mr. LaHart said he prefers Impact Wrestling.
The same people dont win all the time, he said.
Fan Jonathan Gilbo didnt have to stand in line. Like he had done in 2011, the last time the show was offered in Massena, he helped set up the ring and had been at the arena since about 11:30 a.m.
The manager at the Massena Arena asked for volunteers. Setting up the ring is a special treat for me. Its very hard to do, he said.
The evenings other matches featured X Division Champion Kenny King against Rockstar Spud for the title, Magnus against A.J. Styles, Devon against Joseph Park, and Hernandez and Matt Morgan. It also featured the appearance of the renegade group that calls itself Aces and Eights.
Prior to appearing in Massena, Mr. Morgan had been in Plattsburgh the day before to raise money for Nathan Wood, a 17-year-old wrestler from Saranac Central whos battling Ewings Sarcoma, a rare form of cancer.
Mr. Morgan, who stands 7 feet tall and weights 326 pounds, signed autographs and took pictures with local fans at the Champlain Centre Old Navy in Plattsburgh.
All proceeds from the event went directly to the Wood family.
It went really good for Nathan Wood. It was a better turnout than we thought, he said prior to his match in Massena.
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