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......blind testing mentioned by a person that doesn't believe in doing them. Aren't they "too difficult" according to yourself? Wait......nevermind just don't answer that because I know it will end up with you Mr Atkinson making some EXCUSE as to why you can't do blind tests for the magazine when it comes to reviewing products. ZzzzzzzzzzZzzzzz.
The 2011 Richard C. Heyser Memorial Lecture: "Where Did the Negative Frequencies Go?"
The AES website notes that the Richard C. Heyser Memorial Lecture series was established in May 1999 by the AES Technical Council, the Board of Governors, and the Richard Heyser Scholarship Fund to honor the extensive contribution to the Society by this outstanding man, widely known for his ability to communicate new and complex technical ideas with great clarity and patience. The Heyser Series is an endowment for lectures that will bring to AES conventions eminent individuals in audio engineering and related fields.
With thanks to the AES Technical Council for their permission, the preprint of John Atkinson's lecture is presented here.Ed.
Richard C. Heyser Memorial Lecture: "Where Did the Negative Frequencies Go?"John Atkinson, Editor, Stereophile magazine
"Even a cursory read of the academic literature suggests that in audio, all that matters has been investigated and ranked accordingly. But his 40-year career in music performing, record engineering and production, audio reviewing, and editing audio magazines leads John Atkinson to believe that some things might be taken too much for granted. The title of his lecture is a metaphor: all real numbers have two roots, yet we routinely discard the negative root on the grounds that it has no significance in reality. Perhaps some of things we discard as audio engineers bear further examination when it comes to the perception of music. This lecture will offer no real answers, but will perhaps allow some interesting questions to develop."
Good evening, ladies and gentlemen. It is an honor to have been invited to present this evening's lecture in memory of the late Richard Heyser. Audio theorist, engineer, reviewer, scientist at the Jet Propulsion Laboratory, inventor of Time Delay Spectrometry, and Audio Engineering Society Silver Medal recipient, Dick was a man I was privileged to have met just the once, at an AES meeting in London in March 1986. His comments that night gave me much to ponder in the years ahead. I was also in the audience for the presentation of his final two papers to the AES, given by telephone at the fall 1986 AES Convention in Los Angeles, from his hospital bed. I had not realized until that evening that his illness was terminal.
My wife got to know Dick well when they both worked for Audio magazine; she remembers going round a Consumer Electronics Show with him. Before entering each exhibitor's suite, Dick would cover up his name badge: "That way they won't know who I am," he said with his usual modesty, "and I will hear the system as it really is, not how they want 'Richard Heyser' to hear it."
It is also an honor to follow in the footsteps of such visionaries as Ray Dolby, recording engineer Phil Ramone, futurist Ray Kurzweil, mathematicians Manfred Schroeder and Stanley Lipshitz, film-sound pioneer and editor Walter Murch, Andy Moorer of Sonic Solutions and Adobe, Roger Lagadec, Kees Schouhamer Imminck (who developed the optical data-reading technology used in the CD), Karlheinz Brandenburg of MP3 fame, and acoustician Leo Beranek.
When Robert Schulein of the AES Technical Council e-mailed me last summer to invite me to give this lecture, I was sure that a mistake had been made. The gentlemen above invented the future. By contrast, I am just a storyteller; worse, I am a teller of other people's tales, including tales told by some of the people above.
"Writing about music is like dancing about architecture," Laurie Anderson was once supposed to have said, and to be an audio journalist is not too different. However, as a generalist in a world of intense specialization, I think I can dance a step sufficiently varied to cast some interesting shadows.
I am sure that some of the questions I will ask in the next 50 minutes or so have already been answered, perhaps even by one or more of the people in this room. Nothing I will say is either original or new. Much of it has been examined in articles I have written and speeches I have given over the past decades. However, it is unlikely that everything will have ever been grouped together in the same presentation before. And, of course, given the large amount of ground I will be covering, I am well aware that I am skating over crevasses of deeper understanding. So I beg forgiveness for the inevitable generalizations.
Early Days
I had a schizophrenic education. On the one hand, I was an academic overachiever in the sciences. On the other, music meant more to me than any other interest at school, and I continued playing bass guitar in bands, first while I kept my nose to the scientific grindstone at university, and later when I took a job in scientific research.
I started out working, in a government laboratory, on the development of LEDs. This is my ID card at the lablong hair was mandatory for government workers at the end of the 1960s, of course.
One of my tasks was to grow my own junctions, using a slice of a zone-purified n-doped gallium phosphide crystal and depositing a layer of p-doped material on it with a vapor-epitaxy oven. I would then cleave the material into individual dies and make transistors from them under a stereo microscope. I would characterize the charge-carrier mobility by measuring the Hall Effect with an enormous magnetI once stuck my hand in the magnet but felt nothing, despite all the ions in my nerves presumably pressing against one side. I later worked for a mineral-processing laboratory, where I learned to pan for gold, among other skills.
But even as I began slowly climbing the scientific ladder, music pulled even more strongly, and I resigned from the lab in July 1972 to join a band that had just been signed to Warner Bros., and was to make an album at Abbey Road Studio and then embark on a tour of America. Well, we made the album, but our manager did a runner with the advance from Warners and the LP was never released. One memory I have of Abbey Road was this young tape op who, one lunchtime when the producer and engineer were at lunch, sat at the console and did a superb mix of one of our songs.
This slide is a montage of two photos I took in Abbey Road's Studio 3you can see that the tape op sitting by the 16-track Studer machine was a youthful Alan Parsons!
For the next four years I played with other bands, toured, and made other albums, but it eventually became clear that I would need a steadier source of income, and in September 1976 I joined the British magazine Hi-Fi News & Record Review as an editorial assistant. At a magazine devoted to audio equipment and recordings, I felt as if the scientific and musical sides of my brain could finally coalesce. And working on audio magazines is what I have done ever since.
As I said, I am a generalist in a world of specialists. The problem with being a generalist is the vast amount of information published in every field. It is impossible to stay current. Back when the Scientific Method was a radical new idea, and science was the preserve of wealthy gentleman amateurs, it was just about possible for a single person to know everything. But those days are long gone . . . one group of researchers reckon that 1.3 million articles were published in scientific journals in 2006 alone.
I am also old enough that my education in electronics and audio was exclusively based on tubes. Even the logic circuits I constructed at school used tubes! But looking back, I think there was one experience that foreshadowed my career as an audio reviewer. For one of my bachelor's degree final exams, I was handed a black box with two terminals and had to spend an afternoon determining what it was. (If I recall correctly, it was a Zener diode in series with a resistor.) That experience is echoed every day in my endeavors to characterize the performance of the audio components reviewed in Stereophileevery product, be it speaker, amplifier, CD player, is fundamentally a black box with input and output terminals. All I have to do is ask the question "What does it do?" And remember that testing a product is not just a case of pressing "F9" on the Audio Precision; you are faced with trying to get into the head of the designer and asking, Why did he do it this way? What is the trade-off the designer has felt worthwhile? (There are always trade-offs.) And why?
Concours d'elegance
I am addicted to elegant ideas. When I first realized that the square root of negative 1, i, could be visualized as meaning a rotation of 90° into a second dimension of what was hitherto a one-dimensional number line, it was a moment of satori. In the one-dimensional world of numbers, the concept of the square root of negative 1 is meaningless. But by adding a new dimension, you enter a new, rich reality where i does have meaning.
But it didn't take me long to realize that elegance is not always equivalent to truth. As a teenager, I thought that the hypothesis of the Static Universe propounded by Fred Hoyle, along with Thomas Gold and Hermann Bondi (whose passing significance I'll mention later), was supremely elegant. (And it didn't hurt that, as a science-fiction fanatic, I was familiar with Hoyle's fiction.) Hoyle's idea was that, as the universe expands, it causes new matter to be created, if I remember correctly, at the rate of one hydrogen atom per century in a volume "equal to the Empire State Building," so that if you took a series of snapshots of the universe, one every billion years, they would all be identical. Of course, as soon as the cosmic microwave background was discovered, Hoyle was proved completely wrong. (This is ironic, as Hoyle had invented the term "Big Bang Theory" to disparage what turned out to be the correct theory.) But the Big Bang Theory means that the universe had a beginning and will have an end, which strikes me as inelegant in the extreme.
I am also fascinated by things that don't seem to fit. For example, when I first studied the Periodic Table of the Elements, it struck me as very strange that water is a liquid at normal temperature and pressure. If all you knew were the properties of its constituentstwo of the lightest elements in the Periodic Tableyou would expect water to be a gas like hydrogen sulfide, but less dense and less smelly.
But water obstinately isn't a gas, and we all take for granted that it isn't. In fact, our lives depend on it not being a gas. It takes a deeper knowledge of the properties of water to understand why it doesn't fit.
It is the combination of elegance and apparent anomalies that I will be talking about in this lecture. Which brings me to an explanation of its title:
Sure is a lot of blind testing mentioned by a person that doesn't believe in doing them.
A man sees what he wants to see and disregards the rest, eh? In the 15,000 words of this preprint, there are just a few paragraphs devoted to a discussion of blind testing.
Aren't they "too difficult" according to yourself?
As I say, I took part in my first blind test 35 years ago and since then have been involved in well over a 100 such tests, as listener, proctor, or organizer. My opinion on their efficacy and how difficult it is to get valid results and not false negatives - ie reporting that no difference could be heard when a small but real audible difference exists - was formed as the result of that experience.
John Atkinson
Editor, Stereophile
In other words JohnnyR, Mr Atkinson DID find excuses not to use blind testing but found them worthwhile enough to mention them in his Heyser speech funnily enough.
A. Join a band as a second rate bass player
B. Fail to get a record contract
C.Pretend he's an electrical engineer
D.Get an offer to ruin.....ermm I meant run Stereophile
E. Proceed to ruin........ermmmmm excuse me......run Stereophile like Hitler would.
F. Spend his time talking online instead of actually doing any real work.
G. Make excuss about his busy schedule and why he can't do DBTs
H Profit!!!
Johnny makes plywood boxes in his mother's basement, and then claims he is a speaker expert.
Trolls audio websites.
That is all.
JRusskie seems to have become a failed audio (and DBT) expert in one easy step...
A. Failed...
Hitler? I don't know whether to laugh or cry.
I asked a question of Harman Testing Lab in the Computer Audiophile forum, and post #11 is the answer, which I thought was perfect. i.e., let the testee control the switch, so whatever adjustment time they need they can accomodate.
Other observation: The comments in this Stereophile article about the noise floating free of the recording due apparently to having a higher playback bandwith - that made my day.
On R.C. Heyser: His description of the 1971 Sylmar quake, hearing a low-frequency "tone" prior to the shaking, got him started on comparing earthquakes and woofers and low-frequency playback in rooms, and he got beat up on a lot for those writings. But having been involved with both, those observations of his were like gold in the bank. Saved me lots of money.
Aren't you the dude who "tested" the Shure SRH 940 headphones and claimed they were almost as good as the 800HDs from Sennheiser?
I own the SRH940s. I was somewhat willing to believe you, but when I saw that your source was an Ipod, I just flicked your review in the trash.
You chose a 200$ source to test 325$ and 1500$ headphones? And you believe your results mean something?
My review of the 940, agreed upon by more than 95 percent of respondents, was vetted with specific music tracks listed in the review and subsequent comments, using ipods alone, ipods with analog amps, and desktop DACs and amps. Some of the naysayers are either impatient or just grumpy and disagreeable, which the comments in this Stereophile article perfectly illustrate.
How nice of you to call people who question your methodology grumpy, disagreable, etc. I question your methodology because it makes no sense to test 325$ headphones with an ipod. It makes even less sense to test 1500$ headphones with an ipod...
I actually listened to the Shure SRH940 and HD800 today, using my ipod Nano. You are correct, they both sound almost the same. They both sound like shit!
I know from experience that these headphones really shine with a good source, and especially, proper amplification. As good as the Shure is (I own them), it is no match for the HD800 when both are hooked up to decent equipment.
Your test is like testing the acceleration of a Ferrari and a Prius in your 12' driveway. You won't get much better results from the Ferrari in such a limited distance.
As for the 95% who agree with you, what gear did they use (ipod)? Were those 95% SRH940 owners and fanboys?
Saying "they both sound like shit" when one of those is a revered $1500 headphone of great pedigree and popularity among actual audiophiles is telling of your judgement. I would suggest taking a deep breath, pick a headphone and some music tracks you like, then tune out the matrix and just enjoy your music. You'll be less grumpy that way.
Don't try and hide behind my words! They both sound like shit through an ipod! What a weasel you are. I did not say the 800HD sounded like shit... BUT IT SOUNDED LIKE SHIT THROUGH AN IPOD. You rigged your test, Dale.
Again, you use insults...
A long time ago one person on a big audio site challenged people like you to be more specific instead of throwing words like s**t around. There were just two persons who offered test tracks with which to compare those headphones, but everyone else (like you) just threw out expletives, and a couple members even made serious threats. Now I have over 30 years experience comparing headphones like the Stax and Sennheiser series, and quite a bit of time invested with the Audio Engineering Society as well as reading Stereophile magazine, so even if nobody in the world were to agree with my conclusions, I'm certainly qualified to test and evaluate these devices. I'd suggest you refrain from purely ranting with words like s**t and offer specific testable facts, or just go away.
This article may help you:
BTW, and speaking of Prius and Ferrari, you may be one of the better off who don't mind paying $1500 for a headphone and then shelling out $2000 for a headphone amp. But let's pretend for a moment that you have to pinch pennies to get those luxurious goods, so when you finally have them you really appreciate what you have. In this latter case, were you to stumble across an ipod touch or iphone of recent manufacture, with the new Earpods ($29 purchased variety only) being driven by the Dirac DSP player, and had an opportunity to listen at length, it might make you ill to realize what you got for your $3500.
My headphone amp is a whopping 400$ (CI Audio VHP 2).
I do pinch pennies. The VHP 2 and the Shure 940 are mine.The Sennsheiser 800HD I borrowed from a friend.
Stop trying to cloud the issue with non relavant issues.
How about we let Stereophile test both headphones! First through an ipod, then with decent equipment!
Both headphones sound similar through an ipod.
Plug them into a receiver, they sound less like shit.
Plug them into a decent headphone amp, and they both sound MUCH BETTER. BUT the Sennsheiser pulls away and wipes the floor with the Shure.
Buy yourself a CI Audio headphone amp (the one I use), or any other decent headphone amp Dale... Before buying a 2500$ DAC to install on an ipod.
The continuing saga of ChrisS being a troll and all around noncontributing poster. Classy act there ChrisS.
Mostly what I got from Mr Atkinson's article was the amount of photos of himself rather than Mr Heyser. I suppose a memorial lecture should be all about the presenter and how he sees fit to turn it into reasons why Stereophile does what it does regarding testing and the lack there of.
"Yes, what you think you are hearing might by dismissed as being imagination, but as the ghost of Professor Dumbledore says in Harry Potter and the Deathly Hallows, "Of course it's all happening in your head, Harry Potter, but why on earth should that mean that it is not real?"
Oh I see now. Stereophile's philosophy is based upon a ficticious Harry Potter character who spouts that what we hear is real.I'll be sure to let those people being treated for such voices in their heads that all is well and medication is not necessary.
"Footnote 2: For a long time, I've felt that the difference between an "objectivist" and a "subjectivist" is that the latter has had, at one time in his or her life, a mentor who could show them what to listen for. Raymond was just one of the many from whom I learned what to listen for."
Well if only that was true. Your readers tend to all be subjectivsts who aren't trained what to listen to but blindly ( I made a pun there since blind testing is not wanted at Stereophile) believe whatever they think they hear as the truth when in fact measuremnts will show that either they heard nothing related to the measurements or perhaps it's Dumbledore once more in their heads, make believe or wishful hearing.
All in all I found your presentation 90% about yourself and Stereophile and reasons why you defend subjective listening and gloss over things like cables and doing serous testing and throwing in various quotes and ambiguous stories barely related to the subect you were supposed to be talking about, unless that subject was muddling the understanding of Stereophile and telling everyone your own personal history instead of Mr Heyser's.
"Third, one well-known skeptic sitting in the audience tonight criticized my abstract a few weeks back on the grounds that I am just offering "hypotheses about stuff that might be just to stir the pot, while offering no real explanations."
Class act there Mr Atkinson, speak out and criticise someone you don't like or agree with in the audience who then has no opportunity to speak up and address the audience themselves. Very childish and immature.I already see how you do the same on here. "My way or the highway"
JohnnyR is once more sadly correct, Blind testing is not and wil not be used by Stereophile. Just because you Mr Atkinson, know how to push a few buttons to measure speakers, does not make you even close to the same league as Mr Heyser was. He furthered the cause of objectivity and made Audo magazine the best audio magizine there ever was. The Audio Critic is a very close second. Mr Aczel used to be one of the worst subjectivists around untill he admitted to being such and saw the light and spoke out against foolish subjective reviews. Testing will always be the most important part of audio magazines. Simply letting reviewers spout off about "blacker backgrounds" "lifted veils" or other such nonsense belittles both the reader and the so called reviewer not to mention the product under "test". Truth in testing is what Mr Heyser strove for not some silly review about rainbow foil, magic bowls or pebbles.
Mostly what I got from Mr Atkinson's article was the amount of photos of himself rather than Mr Heyser. I suppose a memorial lecture should be all about the presenter and how he sees fit to turn it into reasons why Stereophile does what it does regarding testing and the lack there of. I found your presentation 90% about yourself and Stereophile...throwing in various quotes and ambiguous stories barely related to the subect you were supposed to be talking about, unless that subject was muddling the understanding of Stereophile and telling everyone your own personal history instead of Mr Heyser's.
You have misunderstood the nature of the lecture, GeorgeHolland. The Richard C. Heyser Memorial Lectures are not intended to be _about_ Dick Heyser but instead are offered to honor his memory. The invitation for me to be the October 2011 lecturer clearly stated that I was free to choose any subject I felt appropriate; my triple career as a musician/audio engineer/audio editor and the conclusions I have formed as a result of my 4 decades' experience in those careers were felt by the AES Technical Council members to be an eminently suitable subject.
Class act there Mr Atkinson, speak out and criticise someone you don't like or agree with in the audience who then has no opportunity to speak up and address the audience themselves. Very childish and immature.
The skeptic in question had emailed me before the lecture to let me know he would be in the audience and would take an active part in the anticipated Q&A session. I included this mention in the preprint to give him the necessary opening. As it turned out, he didn't attend, but I saw no reason to delete the point he made.
Just because you Mr Atkinson, know how to push a few buttons to measure speakers, does not make you even close to the same league as Mr Heyser was.
I agree. As you can tell from my discussions of Dick Heyser's writing and thoughts in the preprint, I have an enormous amount of respect for what he achieved. I have never claimed to be his equal, nor would I. But again I must emphasize that the AES Heyser lectures are not intended to be _about_ Dick Heyser. That is your misunderstanding, I am afraid.
John Atkinson
Editor, Stereophile
I am not sure as to why a person would even want to respond to these posts. Some problems really are better ignored as to invoke the spirit of go away. I for one appreciated this lecture for what it is thank you.
I for one appreciated this lecture for what it is thank you.
Appreciate your comment. It is rare that a magazine writer has the opportunity to gather all his thoughts in one place and I owe a debt of thanks to the Audio Engineering Society for inviting me to do so.
John Atkinson
Editor, Stereophile
Whoa! There goes another synapse! Now they're both brain dead... I duelled extensively with JRusskie re: blind testing on the Forums and I daresay, he shot himself many times with his own arguments.
Saga? Can't wait for the movie version!
Sorry, Ariel... I'll try not to let it happen again.
...which is a valuable insight, I think, from this article that Mr. Atkinson has generously preprinted. His stories--which, though I am not a longtime reader, I presume also reflect the history of Stereophile--mirror the tensions found in the philosophy of science between "reality" and "perception", and the question of whether our observations are truly disinterested or if our minds shape how and what we see (or hear). And, really, what exactly does a blind test resolve? That the reviewer likes one piece of equipment over another, presumably without factoring in aesthetics or cost? But "liking" one thing better than another is still a subjective judgment, and who's to say YOU would share that judgment? Never mind the problem of translating sounds heard by another into words on the magazine's page and then back again into the sounds heard by the reader when he or she auditions the gear. Or the issue of whether sound quality can be adequately described by a series of measurements, any more than colour can be described strictly in terms of wavelength, or consciousness in terms of vibrating atoms in your brain. That's not to say these things aren't significant, but to say that they add up to the sum of our human experience is absurd.
Thanks for a reflective and enjoyable article (at least in my mind).
The purpose of blind testing is soley to see if you can hear a difference between two units. After all the subjective rants of "oh this lifted several veils of crud from the liquid sound" or "I heard a definite improvement" I find it sad that Sterophile keeps saying that DBT or even SBT are not a valid way to test those claims. Either you can hear a difference or you can't yet those that claim they do shy away from proving that fact with a blind test. Afaid they might be shown to be wrong is my opinion, so Stereophile allows them to go merrily along in their own self delusions while spending way too much money on sham products.
In a properly set up DBT, let's say for two amplifiers, what exactly will the listener be listening for?
(And what if the lamb heard a difference, but not the shepherd boy?)
Are you seriously so dense that you can't figure it out for yourself? Perhaps that's why you depend upon Stereophile to tell you what to buy?
Read and learn.
So Georgie,
If the lamb can hear that Amp A can make the test system sing in a range of 10hz-60khz, but the shepherd boy can't hear in that range so can't tell the difference between Amp A and Amp B, which amp should the shepherd boy buy?


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By RICHARD SHAWSun Advocate publisher
(Editors Note: This is one of a series of articles about the history of the Sun Advocate and the county it covers as a newspaper. These articles are being prepared as the 120th anniversary of the newspaper's birth approaches in 2011).
On the front page of the Sun Advocate on Jan. 2, 1936, a top-of-the-page piece exclaimed "Another Milestone" as the paper reached it's 45th anniversary (by heredity). It had also been a publication in its own right as the Sun Advocate for three years (having been created from the News-Advocate and The Sun).
The paper's owners exclaimed that the paper had "endeavored to keep stride with (the) advancing march of progress" in connection with "the days of the stage coach (1891) to the current period of motor and airway travel." The editor also stated that it was "a foundation upon which may be built a publication which will in every way be reflective of the progressiveness of the community which it serves."
With that said, a new year began, and while a somewhat mild year of news compared to many others, it still had its big headlines.
The paper itself had changed in the last three years. It had started using photos on the front page for stories, a first for the Sun Advocate. However it was numbers of issues in between when it was done. None throughout 1936 were of any kind of action or view shots, but instead head shots of various officials. Inside the paper had started to use photos more and more in advertising and some national or regional photos taken by those not from the area. While the Sun Advocate was not the first in the area to use extensive photos inside its pages (the News-Advocate and Helper Journal had done it extensively since the late 1920s) they were the first to put them on the front page.
Other changes had come too. The first comic strips started to appear in 1935. Although political cartoons had been used in the areas papers since 1900, comic strips were something else. For the Sun Advocate it began in May of 1935 and they appeared periodically throughout the next few years, seemingly without any rhyme or reason. The first set that appeared in the May 30, 1935 issue had strips that filled two pages. Some strips were named, others were not. Funny ones included Frog Pond Ferry, Buttons and Fatty and Frankie Higgins and his Dog. Frog Pond Ferry was one of the most interesting in that the main character was a snake, something many people dislike. There was also a serious strip called The Pioneers.
As for the format of the paper, it didn't change much except the reporting became more succinct and the opinions offered became more diverse. The paper was a community support, but it also criticized when it had to.
Big stories of 1936 were few, but timely. Unusually, the largest story of the year that was not political (it was a general election year in which Franklin Delano Roosevelt won his second term as president) was a murder that took place in Emery County. That's because the trial took place at the Carbon County Courthouse.
The murder was a double one; the Emery County Sheriff, W.L. Black, and his brother, Roy Black were killed when Hugh Wayman, shot them both over a water rights dispute that had been going on for some time on Aug. 23. Wayman surrendered that day to Ferron Town Marshall George Duncan, admitting at the time that he had done the killings.
To make the murder trial and testimony more convoluted, then main witness was Roy Black's wife, who was also Wayman's sister. The only other witness was 16- year-old Don Olsen, who happened to be walking by when the shootings took place and ran when he heard the shots. Interestingly enough, once it was established the sheriff was dead, Olsen's father, J. Leonard Olsen, was immediatelly appointed the acting sheriff for the county.
During the trial Wayman still admitted he had killed the two, but disputed the background of the incident given by other witnesses. He had pleaded not guilty because he said the shootings were in self defense based on prior threats and actions by Roy Black. It was also reported at one point he was asking for voluntary manslaughter as well.
In the end the jury found him guilty, but not of first degree murder which would have carried the death penalty but of second degree murder for which he as sentenced to life in the Utah State Prison.
The murder and eventual trial shocked the entire Castle Valley area. Stories were told about the relationship of Wayman and his sister, as well as his relationship with her husband Roy. How Will Black tied in other than to be helping out his brother was never really discerned in the news reporting done.
Other important stories of 1936 that the Sun Advocate covered included growing support by various organizations of putting a junior college (as part of the University of Utah) in Price, the establishment of the first local radio station in Carbon County (KEUB).
In February the paper published a special section on the Civilian Conservation Corp camp in Price. It was a three page section and was put together and edited by men from the camp. Camp Price was officially known as Company 593.
The elections also brought more than Roosevelt to office. In the local area the Democrats won heavily and while J. Bracken Lee (a future governor of Utah and mayor of Salt Lake) had been elected as mayor of Price the year before, another local, Reese M. Reese, who had been the Carbon County Treasurer, was elected state treasurer.
The Sun Advocate was becoming more and more sophisticated in both reporting and in typography. It was becoming a modern newspaper in every way. That would become even more evident in the years before the start of World War II.


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We all have points in our career at which we need to make a choice about what to do next. This can happen at any stage – from deciding whether to go to graduate school or find a job in industry, through choosing a postdoctoral position, to deciding what type of position to apply for after completing our scientific training. There are many opportunities to find out all about the academic research career path during graduate school and postdoctoral training – all you have to do is keep your eyes open and talk to the people who are doing it – your mentors and the other researchers you meet along the way (in class, in the department, at meetings etc). 77 things to do with a Biochemistry degree Ph.D. Programs for Apsiring Biomedical Scientists (AAMC)Find the right graduate program at PhD's.ORG Career Insights - Personal Stories told by Other Life Scientists Becoming a Graduate Student Becoming a Postdoctoral Fellow Funding Opportunities ASBMB Job Board
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Linspire Linux Shootout
If you are new to linux, and havent really had a chance to either install or choose -- well, here is a nice place to start. Linspire offers a nice package of Red Hat Fedora Core, Mandrake, and of course Linspire. It can be purchased (39.95 for the boxset) or downloaded (29.99, for the cost of Linspire).
Lindows is nice, as is Fedora. I cant comment too much on Mandrake, since the 9.x series and the 10.0 release hates my system. I have replaced knoppix with LindowsLive 4.5 and OneBase Go. I have truly useful cd (Lindows/Linspire) for work and leisure without any hassle, and a GREAT tool for troubleshooting (OneBase Go).
This is my reccommendation. PM me if there is a similar jumpstart such as this. Until I remove this comment, could some of you do me a favor -- I only own the LindowsLive 4.5 disc. I dont have (yet) the live SuSE disc. What I need is a comparison on the two. That may be added if it works quite well.


text: Louise Chanfrau | IBDB: The official source for Broadway Information IBDB: The official source for Broadway Information Official Broadway League sites: - sites - broadway.org broadwayleague.com broadwayfanclub.com kidsnightonbroadway.com stagespecs.org tonyawards.com Quick Search For: In This Category: All Show People/Org. Theatre Season Louise Chanfrau Performer Productions ProductionsDate of ProductionsThe Geisha[Musical, Comedy, Revival] Performer: Louise Chanfrau [Ensemble]Mar 27, 1913 - May 10, 1913 Find out where Louise Chanfrau and are credited together © 2001-2015, The Broadway League, All Rights Reserved. (Copyright and Disclaimer)


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- Northern New York Newspapers
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OGDENSBURG Sometimes, historical re-enactors have what they call an 18th-century moment, when the present slips away for an instant and they feel as if they are truly a part of history.
Thats the whole reason for doing this, said Michael R. Dickinson, Glens Falls, who dressed in Native American makeup and garb as one of many re-enactors at Ogdensburgs annual Founders Day Weekend.
The festivities are part of 52nd annual Ogdensburg Seaway Festival, a two-day event with a host of activities including a craft show, concerts, and a fireworks display tonight.
Its become an icon of Ogdensburg, said Timothy W. Cryderman, re-enactor and second vice president of the Fort de la Presentation board of directors, which organized the event.
Highlights include mock battles on the river and on land, recreating the French and Indian War and the north countrys colonial history.
The battles were held near the site of a long-since demolished fort that passed through the hands of French, British and American troops during the 1700s.
We think that this really represents the history of the area, Mr. Cryderman said.
Tents were set up nearby, housing a blacksmith and vendors selling period goods. Founders Day drew about 1,500 people last year, according to Mr. Cryderman, a figure he expected to match this year.
The festival has been an Ogdensburg mainstay for over 10 years, drawing re-enactors from all over the northeast, and occasionally as far away as Alaska or Tennessee.
Its a wonderful site, the town is really supportive, said Rebecca J. Cornell, Northfield, Vt.
Cornell is part of the crew of the Dark and Stormy, a replica of a small British naval vessel from the 1700s. The boat was constructed after one of the re-enactors received a small replica cannon for Christmas, and decided he needed something to mount it to.
The group spent three years creating the boat, and the cannon is proudly attached to the front.
We werent sure if it was going to float, Ms. Cornell said, but it did.
Mr. Dickinson is part Native American, and travels to dozens of events every year under the name Cheeksaunkun. He has attended Ogdensburgs Founders Day since the beginning.
The festival is one of many that re-enactors travel to every summer.
I started reenacting when I was about 10, said Chris A. Stringham, Syracuse. Its basically like playing dress-up and war still.
Although they live in far-flung regions, re-enactors see each other regularly at various events, and use social networking sites to stay in touch during the off season.
Its almost more than we communicate with our own families, said David A. Scalzo, Albany.
The Seaway Festival and Founders Day activities continue today, with another naval reenactment at 11 a.m. and a land battle at 1:30 p.m.
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Inside the Pac: Who will win the Pac-12 North?
EUGENE, Ore. - With the Pac-12 dividing the conference into two six team divisions, the West coast will have a big-time Conference Championship game for the first time in history.
While many believe Oregon will win the new North division, there are some who think a team from the Bay Area has what it takes this year to dethrone the Ducks.
To the Cardinal advantage, this year's meeting between Oregon and Stanford is in Palo Alto. Sports Illustrated calls the Oregon-Stanford showdown the biggest games in college football this year.
For the Cardinal, expectations are high despite the departure of energetic head coach Jim Harbaugh to the San Francisco 49ers. Former offensive coordinator David Shaw is now the man in charge, and he remains paired up with all-everything quarterback Andrew Luck, who considered jumping to the NFL as well.
In Seattle, the Huskies are well into the post-Jake Locker era at the University of Washington. Redshirt sophomore Keith Price beat out redshirt freshman Nick Montana for the job in the spring, and another solid season is expected from head coach Steve Sarkisian's squad after last year's Holiday Bowl win over Nebraska.
The Cal Bears have more questions than answers coming off last year's 5-7 season, most notably at quarterback. Transfer Zach Maynard is battling with Brock Mansion and Allan Bridgeford for the starting job. Head coach Jeff Tedford would love to improve on last seasons offensive production, which ranked 73 in the nation at just 26 points per game.
In Pullman, there's a quiet confidence amongst the Cougars at Washington State. Despite the fact that Paul Wulff has just five wins in three seasons, the coach believes that junior quarterback Jeff Tuel and company will surprise a few people in 2011.


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St. Mary Medical Center understands that the key to a healthy community is to create supportive environments for good health by sharing knowledge and resources with our colleagues and community members. St. Mary offers programs and initiatives designed to motivate people and provide the education they need to develop skills and confidence in establishing healthy lifestyles.
St. Mary advocates for health at all levels of society in Bucks County so that everyone may achieve their full health potential. This includes low-income families and uninsured residents through the St. Mary Community Ministries in Bensalem.
The community is encouraged to take advantage of free disease prevention and health promotion services. These services include flu vaccines, screenings and educational seminars for community members of all ages, from children and youth, to adults and mature adults who are in the prime of their lives.
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A Phase Il of a Therapeutic, Recombinant, Biologically Active HIV-1 Tat Protein Vaccine in HIV-Infected, Anti-Tat Negative, ARV-Treated Adult Volunteers (ISS T-003)
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Tat is a key HIV regulatory protein produced very early after infection, prior to virus integration, and necessary for viral gene expression, cell-to-cell virus transmission and disease progression. Previous studies in natural HIV infection, indicated that the presence of a Tat-specific immune response correlates with a lower incidence and reduced risk of progression to AIDS as compared to anti-Tat negative individuals suggesting that an immune response to Tat may exert a protective role and control the progression to AIDS in vivo. Moreover Tat is conserved in its immunogenic regions (both B and T cell) among all subtypes. subtypes. Recent data, in fact, indicate an effective cross-clade recognition of clade B strain-derived (BH-10) Tat protein from the HTLV-IIIB lab-adapted virus strain (Buttò, 2003), which was isolated about 20 years ago (Ratner, 1985), by sera from individuals infected with viruses circulating at the present in Italy and in Africa, thus reflecting the high degree of conservation of the corresponding Tat regions and providing strong formal evidence that a Tat-based vaccine may indeed be used in the different geographic areas of the world, since it is capable of inducing a broad immune response against different virus clades. Based on this rationale and on the positive results of preclinical (Cafaro, Nat Med 1999) and phase I preventive and therapeutic clinical trials with Tat protein (ISS P-001 and ISS T-001, respectively) (Ensoli AIDS 2008, Vaccine 2009; Longo Vaccine 2009; Bellino RRCT, 2009) a phase II therapeutic, open label, clinical study with Tat protein (ISS T-002, ClinicalTrials.gov NCT00751595) was sponsored by ISS and activated in 11 clinical sites in Italy in HIV-infected HAART-treated subjects.In this study, subjects are randomized into two arms to receive 3 or 5 vaccinations monthly; each arm is composed of two treatment groups, receiving 7, 5 or 30 µg of Tat, respectively. Preliminary results obtained from 87 subjects enrolled in the phase II trial ISST-002 ongoing in Italy, indicate that Tat vaccination is safe, immunogenic and capable of reducing the immune dysregulation which persists despite HAART in treated individuals, opening new avenues for a most effective treatment of HIV/AIDS (Ensoli et al,PLoS ONE 2010).
HIV Infections
Biological: Tat
Biological: Placebo
Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
|Official Title:
|A Phase Il, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Immunogenicity and Safety of a Therapeutic, Recombinant, Biologically Active HIV-1 Tat Protein Vaccine in HIV-Infected, Anti-Tat Negative, ARV-Treated Adult Volunteers
- Immunogenicity of Tat protein [ Time Frame: up to 48 weeks ] [ Designated as safety issue: No ]
Induction of specific anti-Tat humoral immune response in terms of IgM, IgG or IgA anti-Tat antibodies.
The induction, magnitude and persistence of the humoral response to the administered vaccination schedule will be compared between the active and placebo groups.
- safety of the Tat protein [ Time Frame: baseline; up to 48 weeks ] [ Designated as safety issue: Yes ]Changes in physical examination findings from baseline;
- safety of the Tat protein [ Time Frame: baseline; up to 48 weeks ] [ Designated as safety issue: Yes ]Changes in vital signs from baseline;
- safety of the Tat protein [ Time Frame: up to 48 weeks ] [ Designated as safety issue: Yes ]Adverse events (including local and systemic reactions to the vaccination schedule occurring during the course of the study);
- safety of the Tat protein [ Time Frame: baseline; up to 48 weeks ] [ Designated as safety issue: Yes ]Changes in standard laboratory safety parameters from baseline
|Study Start Date:
|March 2012
|Study Completion Date:
|July 2014
|Primary Completion Date:
|May 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Group A, Tat
Recombinant biologically active Tat 30 mcg in Phosphate saline buffer, pH 7.4, 1% sucrose, 1% Human Serum Albumin; administered intradermally 3 times at weeks 0, 4 & 8
Biological: Tat
Recombinant biologically active Tat 30 mcg in Phosphate saline buffer, pH 7.4, 1% sucrose, 1% Human Serum Albumin
Placebo Comparator: group B, Placebo
Phosphate saline buffer, pH 7.4, 1% sucrose, 1% Human Serum Albumin, administered intradermally 3 times at weeks 0, 4 & 8
Biological: Placebo
Phosphate saline buffer, pH 7.4, 1% sucrose, 1% Human Serum Albumin
Detailed Description:
Based on this, the ISS T-003 study in South Africa was started; the study is a phase II, randomized, double-blinded, placebo controlled, clinical trial to evaluate (as a primary end-point) and the safety (as a secondary end-point), of a therapeutic, recombinant, biologically active HIV-1 Tat vaccine in HIV-1 infected, anti-Tat antibody negative, ARV-treated adult volunteers with chronically suppressed HIV-1 infection as indicated by a HIV-1 plasma viraemia < 400 copies/ml and a CD4+ T cell count ≥ 200 cells/μl, at screening and documented at least once during the 12 month period prior to screening, irrespective of the pre-ARV CD4 nadir.
After a screening period of up to 21 days, the study duration will be 48 weeks, including an 8 week treatment phase (during which 3 vaccinations will be administered at 4-week intervals) and a 40 week follow-up phase.
This study will be conducted at 1 clinical site in South Africa. 200 Subjects will be randomized in a 1:1 ratio to one of the two treatment groups (Tat 30 mcg or placebo administered intradermally, 3 times).
|Ages Eligible for Study:
|18 Years to 45 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Male and female volunteers aged 18-45 years (inclusive)
- Anti-Tat antibody negative
- HIV-1 infected individuals currently receiving treatment with ARVs
- Chronically suppressed HIV-1 infection as indicated by a HIV-1 plasma viraemia < 400 copies/ml and a CD4+ T cell count ≥ 200 cells/μl at screening, and documented at least once during the 12 month period prior to screening, irrespective of the pre-ARV CD4 nadir.
- Negative pregnancy test for females of childbearing potential (not sterilized and still menstruating or within 1 year of the last menses) to be performed during the screening phase and immediately before each vaccination, and use of an acceptable method of contraception (double barrier methods, combined oral contraceptives, injectable contraceptives or intra-uterine devices) for at least 3 weeks prior to the first vaccination and for the duration of the study
- Has provided written informed consent.
- Agrees to stay in contact with the research site for the duration of the study
Exclusion Criteria:
- Acute illness on Study Day 0
- Body temperature >=37.5 °C on Study Day 0
- Any current AIDS-related opportunistic disease
- Any current neoplastic disease
- Known history of malignant neoplastic diseases [NOTE: Subjects with known history of non-malignant neoplastic diseases that are completely resolved according to the fulfilment of all the specific recovery criteria, in agreement with the current guidelines in medical oncology, are eligible]
- Known history of encephalopathy, neuropathy or unstable CNS pathology, immunodeficiency, autoimmune disease, angina or cardiac arrhythmias, or any other clinically significant medical problems in the opinion of the investigator
- Any evidence, as judged by the investigator, of unstable cardio-vascular disease (e.g. unstable hypertensive disease needing modification or introduction of an anti-hypertensive treatment)
- Chest radiography showing evidence of active or acute cardiac or pulmonary disease within 6 months prior to the study screening visit [Note if no previous chest X-ray available, this will be performed at screening];
- Known history of anaphylaxis or serious adverse reactions to vaccines
- Known history of serious allergic reaction to any substance, requiring hospitalization or emergent medical care (e.g. Steven-Johnson syndrome, bronchospasm, or hypotension)
- Active pulmonary tuberculosis within 12 months of screening as evidenced by chest radiography and/or medical history.
- Any known medical or psychiatric condition which precludes subject compliance with the protocol, specifically, persons with psychotic disorders, major affective disorders and/or suicidal ideation are to be excluded
- Current use of psychotropic drugs prescribed for major psychotic disorders
- Concomitant participation in any study with an investigational product or device
- Current or prior therapy with immunomodulator, immunosuppressive and/or anticoagulant drugs within 30 days prior to administration of the investigational product
- Live attenuated vaccines within 60 days of the first administration of the investigational product [NOTE: Medically indicated sub-unit or killed vaccines (e.g., influenza, pneumococcal, hepatitis A and B) are permitted, but must have been administered at least 4 weeks prior to the first administration of the investigational product]
- Known receipt of blood products or immunoglobulins during the year prior to screening
- Previous participation in an HIV-1 vaccine trial (subjects who are known to have previously participated in the placebo arm of an HIV-1 vaccine trial, and so have never received an investigational HIV-1 vaccine, are eligible for inclusion)
- Known drug and/or alcohol abuse in the year prior to screening
- Use in the last 6 months or concomitant use of anti-CCR5 inhibitors and/or integrase inhibitors and/or fusion inhibitors
- Pregnant or lactating females
Please refer to this study by its ClinicalTrials.gov identifier: NCT01513135
|South Africa
|Medunsa Clinical Research Unit (MeCRU)
|Medunsa, Gaueg, South Africa, 0204
|Study Director:
|Barbara BE Ensoli, MD
|Istituto Superiore Sanita
Additional Information:
|Responsible Party:
|Barbara Ensoli, MD, MD, Istituto Superiore di Sanità
|ClinicalTrials.gov Identifier:
|NCT01513135 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 17, 2012
|Last Updated:
|August 8, 2014
|Health Authority:
|South Africa: Medicines Control Council
Keywords provided by Istituto Superiore di Sanità:
Tat protein,
Therapeutic immunization
Additional relevant MeSH terms:
Contrast Media
Diagnostic Uses of Chemicals
Pharmacologic Actions
ClinicalTrials.gov processed this record on October 06, 2015


text:
Dutch brand Johnny Loco seem to understand that tech-geek advertising for their products won't attract a mainstream clientele - the clientele that is the most lucrative, by the way. Their cheeky, picante and not a little bizarre marketing in these photos show that they understand how to create awareness around their brand and the are clearly aiming for Citizen Cyclists with their angle.
24 September 2010
Selling Bicycles With Johnny Loco
Dutch brand Johnny Loco seem to understand that tech-geek advertising for their products won't attract a mainstream clientele - the clientele that is the most lucrative, by the way. Their cheeky, picante and not a little bizarre marketing in these photos show that they understand how to create awareness around their brand and the are clearly aiming for Citizen Cyclists with their angle.
9 comments:
- 106193497484508739855 said...
I'm not an advertising guru by any means. I love these pictures, but I'm not clear on what benefits would accrue to me if I bought a Johnny Loco bicycle.
- 16:39
- Marco te Brömmelstroet said...
you will then magically transfer to having a cool and adventurous lifestyle and be happy and trendy....
...please pay attention man....do you never watch car commercials, or what ;)?
- 17:54
- Andrew Patrick said...
or does this sort of marketing relegate the bike to the halls of 'timely fashion accessory', as dispensable as the next season's must-haves? i really question whether this kind of advertising benefits bike culture in general--as being one that is inclusive and progressive--or if it reinforces the same types of mindless cultural shortcuts that got us here in the first place. bikes as masturbatory aids...
- 02:22
- ❦ me said...
These adverts look like every other advert I've seen in my 50 years on the planet.
Using a beautiful woman to pique the interest of a male's sexual appetite. Ho hum ... boring.
These look like clothing adverts.
If these models represent "Citizen Cyclists" then I guess I don't belong.
I'm not a tall, skinny, beautiful woman posing by my bike.
I'm an overweight, 50 year old woman who rides her bike to work, shopping, running errands, meeting up with friends etc.
This kind of advertising is so cliché.
Want to sell me your brand of bike? Show "real" people using it in everyday situations.
Fat, middle-aged people (who have money) ride bikes, too.
Show your bikes outside a grocery store, library, school, work, restaurant, on a bike path etc.
Show young, older, old, pretty, plain, slim and fat people. DARE TO BE INCLUSIVE OF EVERYONE!
Andrew Patrick says it much more succinctly than I can ... I agree with his comment.
- 16:27
Have a look to this. A new option for getting new people to bicycle lanes? Easy bicycles :)
- 17:50
Johnny Loco are pretty low quality bikes. Low quality bikes don't help the image of bikes in my opinion.
- 13:22
- lagatta à montréal said...
The photography is beautiful, but I agree with some of the others that it is rather too slick; these are fantasy situations and do remind me far too much of car ads. I far prefer ads showing bicycles in real-life situations, yes of course the situations will always be idealised in publicity, but they should bear some relation to reality.
- 12:43
- lagatta à montréal said...
I know the medium and the "product" promoted in the "This is Amsterdam, and this is my bike" video are very different from the Johny Loco campaign, but I far prefer the former:
http://www.youtube.com/watch?v=EOkqTDdtlc4 It does have style, and no shortage of eye candy (lagatta swoons over the young brunet classical musician, though she could be his mum and is really not into being a "cougar") but there are all kinds and ages of people cycling. The video does have a lot of style though, especially through the montage and the rhymes (in Dutch and some répliques in other languages).
Hope "me" likes it...
- 17:37
I think that the Serengeti is not the natural home of your so-called Citizen Cyclist, who apparently knows no better than to bother wasps in denim cut-offs, or to have a pose-striking daydream while a lion draws near. Discarding all your water in the desert suggests that the cyclist has strayed too far from devil-may-care and ended up in dumb-as-soup.
Clearly a bike for aristocratic, short-lived dimwits.
- 01:29


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- Northern New York Newspapers
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Collins-Hammond Electric Second Vice President Gary S. Hammond has been proposed for membership on the Ogdensburg Growth Fund Development Corp.
Mr. Hammonds letter of interest in joining the citys small business lending agency was discussed at Wednesdays Growth Fund board meeting.
Chairman and Mayor William D. Nelson and members City Manager John M. Pinkerton, Scott M. Wright, James McCarthy and Dallas Sutton were receptive, so Mr. Hammonds name will be put before the Ogdensburg City Council for approval.
If the council votes to approve the appointment, Mr. Hammond will serve a two-year term. Mr. Hammond, 44, said Wednesday he wanted to join the Growth Fund board because he was impressed by its role in nurturing the citys business community and the work being done by City Planning and Development Director Andrea L. Smith.
Its good to see movement on the business front, he said. Id like to have some input.
Collins-Hammond, located at 7724 Route 68, has been in the electrical contracting business in Ogdensburg for 30 years.
Mr. Hammond is a native of Heuvelton who lives in Ogdensburg.
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text:
Keratosis palmoplantaris papulosa
Other Names for this Disease
- Buschke fischer brauer syndrome
- Buschke-Fischer-Brauer syndrome
- Keratoderma, palmoplantar punctate type 1
- Keratodermia palmoplantaris papulosa, Buschke-Fischer-Brauer type
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
punctate palmoplantar keratoderma.[1][2][3] Signs and symptoms begin in early adolescence or later and include hard, round bumps of thickened skin on the palms of the hands and soles of the feet.[1][2][4][3][5] KPPP is usually inherited in an autosomal dominant manner and can be caused by mutations in the AAGAB gene.[5] Treatment options may include chemical or mechanical keratolysis as well as systemic acitretin. Some affected individuals have used surgical approaches consisting of excision and skin grafting.[6]Keratosis palmoplantaris papulosa (KPPP) is a rare condition that affects the skin. It is a type of
Last updated: 11/12/2012
- Martinez-Mir A et al. Identification of a locus for type I punctuate palmoplantar keratoderma on chromosome 15q22-q24. J Med Genet. 2003;
- Oztas P et al.,. Punctate palmoplantar keratoderma (Brauer-Buschke-Fisher Syndrome). Am J Clin Dermatol. 2007;
- Asadi AK. Type I hereditary punctuate keratoderma. Dermatology Online Journal. 2003;
- Erkek E et al.,. Type I Hereditary punctuate keratoderma associated with widespread lentigo simplex and successfully treated with low-dose oral acitretin. Arch Dermatology. 2006 Aug;
- KERATODERMA, PALMOPLANTAR, PUNCTATE TYPE I; PPKP1. OMIM. November 6, 2012; http://omim.org/entry/148600. Accessed 11/9/2012.
- Rapprich S, Hagedorn M. Surgical treatment of severe palmoplantar keratoderma. J Dtsch Dermatol Ges. March 2011; 9(3):252-255.
- Palmoplantar keratoderma. DermNet NZ. 2005; http://www.dermnetnz.org/scaly/palmoplantar-keratoderma.html. Accessed 3/10/2010.
- Punctate-type palmoplantar keratoderma. DermNet NZ. 2005; http://www.dermnetnz.org/scaly/punctate-keratoderma.html. Accessed 3/10/2010.
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In Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Keratosis palmoplantaris papulosa. Click on the link to view a sample search on this topic.
Other Names for this Disease
- Buschke fischer brauer syndrome
- Buschke-Fischer-Brauer syndrome
- Keratoderma, palmoplantar punctate type 1
- Keratodermia palmoplantaris papulosa, Buschke-Fischer-Brauer type
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


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Moderators: Timko, Solty, Frank Delicious, Blake_T, Fritz, Booter
keltik wrote:He showed us his grip (it's not what you would expect).
JR wrote:This grip adds a lot of grip on top of the disc. Since grip strength puts a limit to power transfer to the disc it also sets the maximum available distance.
JR wrote:The further toward the center of the disc the thumb is the tighter the forearm muscles get.
JR wrote:Slowing down the arm pull and making it harder the push the front of the disc down with the thumb.
keltik wrote:
Users browsing this forum: Google [Bot] and 4 guests


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15 U.S. Code § 197e - Repealed.
Section, act Mar. 3, 1927, ch. 365, § 6,44 Stat. 1396, provided for travel and subsistence allowance to officers, employees, etc., of Bureau of Foreign and Domestic Commerce on duty abroad or away from duty post.
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I mean, it's not like there is a tuna vegetable or animal that it can be confused with.
I agree with you that it does seem redundant. However, this is common with other kinds of fish as well. Many people say "codfish" instead of "cod". Here is a recipe for "trout fish" croquets.
This convention has important meaning to a huge number of fish names: catfish, lionfish, swordfish, sunfish, cowfish, etc.
Also, it provides extra clarification for someone who wouldn't know what a "tuna" or a "cod" is otherwise. Anyone learning English as a second language will probably learn the meaning of "fish" early on, but may not know the more specific names.
Tuna or cod is not always fish, just as cheddar is not always cheese.
In both cases, it distinguishes the primary item from items merely flavored with the item.
Tuna fish is almost always the meat of the Tuna. Seldom is it the fish itself alive and/or whole; for those uses, "tuna" is used without "fish." Tuna salad is a mixture of tuna and mayonaise, and often some diced pickles and/or onions. Tuna sandwiches are sandwiches using tuna, and can be grilled or tuna salad. Tuna crackers are tuna flavored crackers. Tuna alone also can be a crude aphorism for female genitalia.
Cheddar is both the cheese, and the city where the recipe originates. Several cheeses are likewise named for their place of origin, most notably swiss, münster, and berkswell. But cheddar crackers are not made of cheddar, nor do they originate in cheddar, but are flavored with cheddar cheese. Cheddar spread is mostly cheddar cheese,
Cod can be the fish, or the meat of the fish; a cod dinner is seldom just codfish, but usually also chips (fries) and/or hushpuppies (corn fritters). The USS Cod is a submarine. Cod is also an extremely common acronym, most commonly for "Cash on Delivery." Codpiece is a male pubic covering; cod at one point was slang for the scrotum, so codfish was a way of ensuring one was talking about fish and not men's genitals.
Speaking of corn fritters, I've never met a fritter that wasn't made with cornmeal; I'm TOLD they exist... Likewise, most have also wheat flour and whole kernel corn. It's another case of a term that at first appears to be redundant, but really isn't.
Tuna is used to mean the fish, and the flesh of that fish (which is also called tuna fish).
Tuna is also the edible fruit of a cactus, or the name of that cactus.
I think the reason cheese gets appended to Cheddar much more often than to Double Gloucester, Brie, Camembert, Wensleydale etc. is because it's the most common type. The archetypal cheese, as cod is the archetypal fish. (and I've heard codfish, but not haddockfish or salmonfish). And in UK at least, tuna is the most common canned fish.
As an archetype, it often thus gets to represent not just it's own particular type, but all cheeses. After a restaurant meal I might ask for some Cheddar Cheese - I may not really care which cheese I get, but most likely if they have any, they'll have that. If they do have alternatives I'll doubtless be offered them, but I'd be irritated by a waiter who included cheesecake in the offerings after I'd asked for Cheddar Cheese.


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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
North country schools may finally get some of the money theyve been asking for.
In Gov. Andrew M. Cuomos 2013-14 executive budget proposal, most schools would get increases in aid after years of budget cuts.
This years budget proposal takes out less money to offset the states deficit, also known as the Gap Elimination Adjustment, according to Jack J. Boak Jr., Jefferson-Lewis Board of Cooperative Educational Services superintendent.
We were hoping theyd eliminate the Gap Elimination Adjustment completely, but they didnt do that, Mr. Boak said.
He said that while schools will be receiving more money, many have been teetering on the edge of insolvency for several years.
Its not as good as we would have liked it, Mr. Boak said.
Mr. Cuomo proposed a range of aid as high as $46.75 million for Indian River Central School District and as low as $2.3 million for Colton-Pierrepont Central School District.
In total:
n Jefferson County schools are proposed to receive $179,946,755 in total aid, a $7,570,740 increase from this year.
n Lewis County schools are proposed to receive $54,077,946, a $1,008,939 increase from this years state aid.
n St. Lawrence County schools are proposed to receive $187,696,927, a $7,883,541 increase from this years aid.
The biggest losses in total aid were found in Lewis and St. Lawrence counties:
n Copenhagen Central School District is proposed to lose $192,714, a 2.6 percent decrease from the current year. The district has $ 7,270,210 in proposed aid for next years budget.
n Clifton-Fine Central School District is proposed to lose $59,610, a 1.3 percent decrease from the current years budget.
The district has $4,474,814 in proposed aid for next years budget.
n Colton-Pierrepont Central School District is proposed to lose $84,481, a 3.5 percent decrease from the current years budget. It has $2,310,469 in proposed aid for next years budget.
St. Lawrence County also saw some of the biggest increases in proposed aid in the north country.
Ogdensburg and Canton really stick out as the ones that got really good increases, said Assemblywoman Addie J. Russell, D-Theresa.
Ogdensburg is looking at a 10.9 percent increase in proposed aid, about $23.4 million in total.
Canton has a 9.85 percent increase in proposed aid, about $14.3 million in total.
The governors proposed budget also reflects his support for full-day prekindergarten, increased time in the classroom, targeted aid for high-need districts and money to help offset increases in fixed costs, such as health care and retirement benefits.
One of the things the school supers have been discussing is the spike in pension, Mrs. Russell said. What hes proposing is to provide a long-term stabilization program that would bring that down to 12.5 percent for the Teachers Retirement System.
State Sen. Patricia A. Ritchie, R-Heuvelton, said she was happy to see that Mr. Cuomo wanted to funnel more money to needier districts.
I applaud the Governors effort to steer more education aid to rural schools like ours, she said in a news release. I look forward to studying his proposal with a goal of making the aid formula more equitable and making sure our schools get their fair share.
Mrs. Russell agreed that the state aid formula needed to change in order to be more equitable.
We not only need to drive the money to high-need schools, but we also need to change the formula, she said.
The 2013-14 executive budget proposals school aid figures can be found at http://publications.budget.ny.gov/eBudget1314/fy1314localities/schoolaid/1314schoolruns.pdf.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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The children of Beverly and Howard welcome you to join them to celebrate this momentous occasion of these years together and the family created from their years of marriage before they found each other (30 for her, 40 for him, 10 together - 80 years of marriage combined) All of these years were instrumental in creating this "rock solid" relationship.
Food and music will be provided. While no gifts are requested, if you would like to bring a special reminder, a rock selected by you that can be added to their special rock garden in their yard is welcome and appreciated.A celebration will be held Saturday, May 1 from 3-6 p.m at the Huntington Senior Center, 179 W. 100 N.


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JIFFY STEAMER COMPANY, LLC, RECEIVES SHARP WORKPLACE SAFETY AWARD70-YEAR-OLD MANUFACTURING FIRM EARNS SAFETY AWARDNASHVILLE - Tennessee Department of Labor & Workforce Development Commissioner James Neeley announced that Jiffy Steamer Company, LLC, in Union City was chosen to receive the SHARP (Safety and Health Achievement Recognition Program) award. The award was given this spring at the Annual Tennessee Safety and Health Congress in Nashville.�Jiffy Steamer has the remarkable distinction of being in business since 1940,� said Labor & Workforce Development Commissioner James Neeley. �We are pleased to honor this fine company for their notable safety record.� Jiffy Steamer Company is the world�s oldest and largest manufacturer of garment steamers for personal and professional use. �Jiffy Steamer is proud to accept this safety award from Commissioner Neeley and the State of Tennessee Department of Labor & Workforce Development,� said Clint Joiner, Chief Operating Officer for Jiffy Steamer Company, LLC. �As a family-owned company, we have a strong commitment to provide a safe working environment for our associates. We thank the department for recognizing our unwavering pledge to workplace safety.��As an employee, it is nice to work for a company that places a top priority on safety and a company where continuous improvement is always encouraged,� said Billy Williams, Jr., Safety Manager for Jiffy Steamer.The SHARP award, designed for smaller employers with fewer than 250 workers in high-hazard industrial classifications, is one of the state�s highest honors for workplace safety and health. The main incentive for participation in the SHARP award program is the desire by employers to promote a safe and healthy workplace. The program also allows employers to be removed from programmed compliance inspection lists for a period of 12 months.For more information on the SHARP award program, contact TOSHA�s Consultative Services office at (800) 325-9901.
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The landscape of American health and medicine is changing. You're looking for a master's degree that will give you the skills and knowledge in integrative medicine that you need to be ahead of the curve – valued by medical professionals and sought after by patients.
Whether you're a licensed, mid-career professional seeking to expand the treatment modalities you offer, or hoping to transition to a new career path, getting a fully accredited M.S. in Mind-Body Medicine from Saybrook University will enable you to bring the concepts of holistic health into your workplace, community, or practice.
While getting your M.S. in Mind-Body Medicine, you'll gain valuable experience with the practical application of proven Mind-Body Medicine techniques. Among other areas, you'll study:
- Mind-Body Medicine and Integrative Health
- Psychophysiology
- Coaching
- Movement, Exercise, and Health
- Guided Imagery
- Scientific Advances in Psychoneuroimmunology, the Neurosciences, and Consciousness Studies
- Applied Hypnosis or Applied Biofeedback
The courses you'll take are based on the highly regarded curriculum developed by the Center for Mind-Body Medicine in Washington, D.C. The skills you'll learn have received national recognition from the major professional certification organizations such as the Biofeedback Certification Institute of America (BCIA) and the American Society of Clinical Hypnosis (ASCH).
Just as importantly, you'll be connecting one-to-one with leaders in the field of integrative health care: faculty who provide training in the latest Mind-Body Medicine protocols around the globe, like Don Moss; who have created working models of American community health care that is affordable and holistic and are widely recognized in their fields as being leading experts in the techniques and tools of integrative medicine, like Eric Wilmarth.
Talk to an admissions specialist by calling 888.308.0032-- or Apply now!


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By Carol Spicer.
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By Brett Voss.
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Clifton Record
310 W. 5th St.
Clifton, TX 76634
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2 U.S. Code § 121 - Senate restaurant deficit fund; deposit of proceeds from surcharge on orders
The Committee on Rules and Administration of the United States Senate is authorized and directed hereafter to add a minimum of 10 per centum to each order in excess of 10 cents served in the Senate restaurants and 20 per centum to all orders served outside of said restaurants, and the proceeds accruing therefrom shall be placed in a fund to be used in the payment of any deficit incurred in the management of such kitchens and restaurants.
Source(May 18, 1937, ch. 223, § 1,50 Stat. 173; Aug. 2, 1946, ch. 753, title I, § 102,60 Stat. 814.)
1946—Act Aug. 2, 1946, substituted "Committee on Rules and Administration" for "Committee on Rules".
Effective Date of 1946 Amendment
Act Aug. 2, 1946, ch. 753, title I, § 142,60 Stat. 834, provided that the amendment made by that act is effective Jan. 2, 1947.
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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By RON PATTERSONCarbon USU Extension agent
Spiders are an important part of the ecosystem. Spiders are generally beneficial in that they are predators of most insect pests.
As the weather turns cold, homes in Carbon County get invaded by insects and spiders.
Most spiders do not survive well indoors. However, spiders in the house are never fun.
The bite of most spiders causes nothing more than a slight skin irritation. A few spiders, however, can produce a serious reaction in people. These include the black widow, hobo and brown recluse spiders.
Most people can recognize and avoid the black widow and the brown recluse has not been documented in Utah.
A major concern that is spreading throughout Utah is the hobo spider.
The hobo spider was introduced into the United States through Seattle several years ago and has been spreading from Washington across the country.
There have been no documented cases of hobo spiders in Carbon County. But there have been some hobo spiders confirmed in Sanpete and San Juan counties.
Local residents should capture and bring suspected hobo spiders into the USU Extension office at the county courthouse for identification.
Hobo spiders can be found outdoors year-round. But the adults are most commonly found indoors from July through September, when males wander in search of female mates.
Females tend to stay in funnel-shaped webs in protected corners and behind furniture inside homes or buildings.
Most bites are inflicted by males from July through September.
The hobo spider bite has the potential to cause serious injury to humans. Symptoms vary with the spider's life stage.
Bites from males in July to September usually result in lesions and systemic spread without serious illness.
Extensive injection of poison by males may result in more serious effects such as blood and organ damage.
Bites by females, usually in late October to December, tend to cause less injury - generally a well-defined reddened area with a white pinpoint blister.
Bites by immature hobo spiders occur rarely from November to May, but tend to be the most serious. Extensive lesions, severe systemic effects and blood disorders or internal organ damage may occur.
The definitive characteristic of the hobo that must be viewed with a microscope include the number and position of teeth on the spider's jaw.
The hobo resembles other members of the funnel-web spider family that are harmless or cause minor bite reactions.
For this reason, identification of suspected hobo spiders should be confirmed by an entomologist or trained person.
Extension offices and the Utah Plant Pest Diagnostic Lab on the USU campus provide spider identification assistance.
For information on sample submissions, residents with Internet access may visit http://extension.usu.edu/cooperative/uppdl.
A combination approach to spider control in the home is generally more effective than relying on a single method. Habitat modification, exclusion, trapping, avoidance of risk and chemical control are effective control options.
�Habitat modification includes cleaning frequently behind furniture, along baseboards, in corners behind doors and in other undisturbed areas.
Hobo spiders are more common in basements and on the first floor of the home. The spiders do not climb smooth surfaces and prefer to move downward.
Vacuum cleaner bags can be frozen to kill spiders before disposing.
Outdoor debris, including wood piles, should be removed and overgrown vegetation should be pruned away from foundations.
Large cracks or cavities should be filled with mortar or cement.
Exclusion methods include installing effective under-door seals, repairing window screens and sealing all cracks that may allow spider entry.
Spider traps may be purchased at many home supply stores. Traps may also be made from a cardboard paper towel tube and sticky adhesive. Traps provide monitoring information and control.
�Avoiding risk involves awareness and elimination of situations where hobo spiders are likely to be encountered.
Indoor sites such as the basement floor, furniture and bedding that touch the floor and undisturbed areas with funnel webs are likely places to encounter the spiders.
When working outdoors, protective clothing should be worn when in potential habitats such as wood piles, tall vegetation and storage areas.
Chemical insecticides are generally not effective without the use of other control measures.
Insecticide formulations that are applied dry and form a suspension rather than a solution are more effective against spiders since the active ingredient remains on the surface.
Recommended insecticides labeled for indoor spider control include four types of formulation. Types include dusts like bendiocarb, boric acid, cyfluthrin, diatomaceous earth and pyrethrins; wettable powders like cyfluthrin, cyhalothrin, cypermethrin and esfenvalerate; flowable concentrates like bifenthrin and carbaryl; and microencapsulated suspensions like cyfluthrin and pyrethrins.
Most of the products are restricted to use by commercial applicators.
Local residents should always carefully read and follow the label before using.
The hobo is not aggressive and most bites occur when the spider is trapped in clothing or bedding.
Understanding the spider's behavior and habitat preferences is helpful in preventing bites.
For more recognition and control information, residents may review see the hobo spider fact sheet number 86 by Alan Roe on the USU Extension website at http://extension.usu.edu/insect/fs/hobospid.htm.


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From Ancestry.com. Search 4000 databases of census, vital, church and immigration records.
Includes census information going back to 1790, Freedman's Bank records, primary sources and more.
The site features publications and indexes, as well as information about meetings, membership and genealogy classes.
CGS is the oldest genealogical society in Colorado. They meet regularly and offer classes for beginners.
How to Find More Information:


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Luxury Two Queens
What Makes This Room Different
Located in Harveys Lake Tower our 525 sq ft Luxury Room was recently remodeled and offers two queen beds. Remodeled features include updated furnishings and flat screen TV with separate shower/tub, and High speed internet access available (Fees may apply). Maximum of 4 occupants per room, additional charges apply for third and fourth occupants. All Harveys rooms offer Valet, Bell, and Concierge service. Dogs allowed in Pet Stay rooms only. This is not a Pet Stay room.
Workspace : Desk
Furniture : Mark Allen
Refrigerator : No
Square Footage : 525
Smoking/Non-Smoking : Both
View : Mountains or Town
Decor : Modern
Sheets : 80% Cotton, 20% Poly
Mattress : Simmons Beauty Rest
Window Treatments : Drapes
Shower Head : American Standard
Robes : No
Hair Dryer : Yes
In-Mirror TV : No
Bath Products : Gilchrist & Soames
Vanity : Yes
Makeup Mirror : Yes
Tub/Shower : Yes
Phone : Yes
Alarm Clock : Yes
Iron w/ Board : Yes
Coffee Maker : No
Television : Yes
Telephone : Yes
DVD Player : No
iPod Stereo : No
CD Player : No


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Trout Fitz Roy T-Shirt (Men's)
In Stock Product Number: 24294
Carry a piece of the southern Andes close to your heart. Our Trout Fitz Roy T-Shirt combines what we love best about the raw Patagonia landscape: wild trout and towering vistas. The large back logo is printed on our standard-weight 5.4-oz organic cotton (100%) fabric with inks that are PVC- and phthalate-free. Taped shoulder seams are smooth next to the skin.
* This product does not qualify for shipping to all countries.
- Ringspun long-staple organic cotton for softness and durability
- Screen-print inks are PVC- and phthalate-free
- Taped shoulder seams for comfort and fit retention
- Artist: Patagonia Logowear Crew
Gender: Men's
Weight: 196 g (6.9 oz)
Material: 5.4-oz 100% organic cotton
Fit: Regular fit
Season: S15
Vendor ProductId: 51808
Review ProductId: 24294
Reviewed by 1 customer
- Soft
- Stylish
Best Uses
- Casual Wear
Comments about Patagonia Trout Fitz Roy T-Shirt (Men's):
This t-shirt makes me look so cool.
- Fit:
- Feels true to size
- Length:
- Feels true to length
- Was this a gift?:
- No


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Our Work
The ACLU of Northern California defends and advances civil liberties and rights. We work to make constitutional rights a reality for everyone. Our legal and legislative advocacy fights for freedom, fairness, justice, and equality. With our organizing and public education, we empower communities and help people stand up for their rights.
Know Your Rights
Knowledge is power. When you know your rights you can better protect yourself, your family, and your community. En español »


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- Musician's Friend Best Selection, Price & Service. Guaranteed.
Call our Gear Heads
at: 800-449-9128
Call our Gear Heads
at: 800-449-9128
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The guitar's body showcases expert craftsmenship and is fitted with the refined hardware G&L is known for....
Our product catalog varies by country due to manufacturer restrictions. If you change the Ship-To country, some or all of the items in your cart may not ship to the new destination.


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Palestinians Support Samer al-Issawi At Court In Jerusalem
Supporters of Samer al-Issawi, a Palestinian prisoner on a hunger... NyhetsfotoFånge,Horisontell,Hunger Strike,Israel,Jerusalem,Juridisk domare,Mänskligt intresse,Palestinsk kultur,Protest,Rättegång,Rättsväsendet,TingshusPhotographer Uriel SinaiCollection: Getty Images News 2013 Getty ImagesJERUSALEM, ISRAEL - FEBRUARY 21: (ISRAEL OUT) Supporters of Samer al-Issawi, a Palestinian prisoner on a hunger strike, demonstrate outside the Magistrate's Court on February 21, 2013 in Jerusalem, Israel. Issawi, one of the prisoners who was released under terms of the 2011 Gilad Shalit prisoner swap, was rearrested last July on charges of violating the terms of his release when he took his car to a garage in the West Bank. (Photo by Uriel Sinai/Getty Images)


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by Heather Wolfson
During the Southwest NEXTwork Launch a question about programming caught my eye. Specifically, what types of programs can we, as engagement professionals, create for young Jewish adults that are not only engaging, but also worth people's time? I believe it means developing relevant and authentic events. Here's how:
1. Consult with participants. Don't hesitate to conduct an informal focus group of your participants to find out what they want.
2. Develop goals and objectives. Before developing the program out, go into it with clear ideas of what you want people to get out of the program.
3. Get buy-in from key participants. Have some of your participants been clamoring for a specific type of event? Is this program someone's idea? Don't do it all yourself — involve participants throughout the process.
4. Think outside the box. Get as creative as possible. Consider the content, venue, food, presenters, entertainment…etc.
5. Present meaningful content. Participants should walk away with a new nugget of knowledge.
6. Set the mood. The tone of the program is really important. Fostering a warm and welcoming environment is critical. Have greeters at the door, floaters to connect with new people and always do a short ice breaker (clearly dependent on number of people in attendance).
7. Create action. What is one thing people can do when they go home? Think about how this program can be relevant beyond the program itself.
8. Plan for follow-up. Before the program begins, know how you want to follow up with everyone in attendance, more than just a thank you. Provide participants with links to other programs of interest, educational resources or anything else that may have come out of your program.
Heather Wolfson is the Western Regional Director for NEXT: A Division of Birthright Israel Foundation.


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Sucker Punch is a movie about young women in a mental hospital who escape into fantasies in order to cope with their surroundings. The Sexy Adult Sucker Punch Blondie Costume is one of the women's fantasy alter ego. It features a bodysuit, belt, glovelettes, and thigh highs. The zip up romper is black with studded brown trim at the shoulders. The brown leather like belt has several bands and long fringe that hangs to the knees. The fingerless glovelettes are matching brown faux leather with fringe. They extend over the elbows and up the arms. Black thigh high stockings are included as well. Pick up the prop axe, boots, and a wig, all sold separately. Blondie was a fierce fighter and an erotic dancer in the fantasy scenes. You can create your own fantasies with the Sexy Adult Sucker Punch Blondie Costume.
Our Price: $5.99
Our Price: $24.97
Our Price: $54.97
Our Price: $41.97


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Empower your workforce with everything they need to efficiently install, inspect, maintain, and repair assets in the field. The SAP Work Manager mobile app also mitigates the risk of injury by helping workers complete safety checks and follow safe work practices.
Find out how asset-intensive companies are using the SAP Work Manager mobile app to empower maintenance crews to work more safely, productively, and independently in the plant and in the field. The app helps raise performance and reliability across plants, fleets, networks, and infrastructure.
See how SAP Work Manager allows you to quickly dispatch work orders and notifications to your mobile employees. The app gives them real-time access to asset history and details, and allows them to start, hold, transfer, create and complete work orders right on the mobile device.
Transform the way you manage your asset-intensive business – with SAP Enterprise Asset Management (EAM) mobile apps. Improve business processes and execution, enhance safety and compliance – and give field workers the power to collaborate in real time.


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Come to the mill area for a family
night of history. This year's theme is the 1920's.
Advance registration required - call Julie at 563-299-6024 after Sept. 10th.
No admission fee.
This event is sponsored by the
Friends of the Pine Creek Grist Mill at Wildcat Den State Park
Location: 1884 Wildcat Den Road,
Muscatine, IA 52761


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Located in the financial capital of the world, we offer master's degrees in business administration, international business finance, human resources management and accounting. Student-centered, we have evening and weekend programs so you can integrate theory and practice by pursuing your degree while continuing to work, and rolling admissions, for maximum flexibility.
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