text:
TDF Long Term Study
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- How to Read a Study Record
This study will assess the safety and efficacy of generic TDF from Governmental Pharmaceutical Organization (GPO) in HIV-infected children
HIV-infected Thai Children
Drug: tenofovir (TDF)
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|Efficacy and Safety Evaluation of TDF-based Regimen in Thai HIV-infected Children
- viral load [ Time Frame: week 48 and 96 ] [ Designated as safety issue: Yes ]Number of patients who have viral load less than 50 copies/ml at week 48 and week 96
- renal status [ Time Frame: weeks 24, 48, 72, and 96 ] [ Designated as safety issue: Yes ]Number of patients with renal toxicity assessed by GFR and with proximal tubular effect
- adherence [ Time Frame: every 3 months ] [ Designated as safety issue: No ]Agreement between self reported adherence by visual analogue scale (VAS) pill count and TDM Sensitivity and specificity of self-reported adherence and pill count against gold standards of TDM and undetectable viral load
- resistance [ Time Frame: every 3 months ] [ Designated as safety issue: Yes ]Resistant mutations in patients who fail TDF-based regimen and response to new regimen
- adverse events [ Time Frame: weeks 24, 48, 72, and 96 ] [ Designated as safety issue: Yes ]Proportion of patients who develop adverse events which are related to TDF and other ARVs
Biospecimen Retention: None Retained
Phlebotomy will be for safety evaluation and will be drawn according to the schedule of visit.
|Study Start Date:
|December 2010
|Study Completion Date:
|August 2013
|Primary Completion Date:
|August 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
tenofovir (TDF)
HIV-infected children who are currently on TDF-based regimen or are changing to TDF based on their clinical indication
|Drug: tenofovir (TDF)
Detailed Description:
TDF is a nucleotide reverse transcriptase inhibitor (NRTI) which can be taken only once per day and continues to have good efficacy even in patients who have resistance to other NNRTI in the absence of K65R mutation. TDF is a choice for patients with NRTI resistance, or those that require once-daily regimen to improve adherence. Currently, TDF has not been approved by the US FDA for children less than 18 years, but pediatricians has been using TDF in children who have treatment failure because of limitation of a more appropriate pediatric ARV. The Thai national guideline for pediatric 2009 recommend the use of TDF in children who have failed the first line therapy with multi-NRTI mutation and are more than 30 kilograms or have tanner stage 4 or more. However, the problem is that there is no pediatric TDF formulation. The available preparation of 300 mg tear drop tablet, if cut in half, may increase dosing errors, more or less by 18-37%. This will affect the blood level and/or toxicities. Therefore, the Thai Governmental Pharmaceutical Organization (GPO) has produced a generic TDF formulation that can be used in HIV-infected children. This study will assess the safety and efficacy information in children using this generic pediatric TDF formulation.
|Ages Eligible for Study:
|8 Years to 18 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
HIV-infected children who are currently taking or are changing to tenofovir-(TDF) based regimen
Inclusion Criteria:
- children who are changing to TDF due to adherence problem or treatment failure
- children who are already on TDF due to their clinical indication
Exclusion Criteria:
- child/caretaker refuse to participate in this study
- cannot adhere to the study schedule
Please refer to this study by its ClinicalTrials.gov identifier: NCT01815255
|Bangkok, Thailand, 10330
|King Chulalongkorn Hospital, Chulalongkorn University
|Bangkok, Thailand, 10330
|Principal Investigator:
|Wasana Prasitsuebsai, MD
|The HIV Netherlands Australia Thailand Research Collaboration
|Principal Investigator:
|Jurai Wongsawat, MD
|Bamrasnadura Institute
Additional Information:
|Responsible Party:
|The HIV Netherlands Australia Thailand Research Collaboration
|ClinicalTrials.gov Identifier:
|NCT01815255 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 7, 2013
|Last Updated:
|March 26, 2015
|Health Authority:
|Thailand: Ethical Committee
Keywords provided by The HIV Netherlands Australia Thailand Research Collaboration:
TDF-based regimen
HIV-infected children
safety and efficacy
renal status
To assess effect of TDF on renal problem in HIV-infected children receiving TDF-based once daily regimen
To compare the effectiveness and clinical usefulness of different tools of adherence
Additional relevant MeSH terms:
Anti-HIV Agents
Anti-Infective Agents
Anti-Retroviral Agents
Antiviral Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Nucleic Acid Synthesis Inhibitors
Pharmacologic Actions
Reverse Transcriptase Inhibitors
Therapeutic Uses
ClinicalTrials.gov processed this record on October 13, 2015


text:
Hello, I'm using a Logitech MX518 mouse + Set Point driver.
Problem is that the mwheelup and mwheeldown actions are not behaving correctly and consistently.
For example, if I do 1 mouse wheelup movement (I'm sure of this, I can feel a single "tick!" on the mouse), this will successively change weapon 3 or 4 times. If I do again, it will change 2 or 3, and so on: it seems to behave pretty random.
I had no problem with QuakeLive and this mouse until about 4 monthes I guess (I noticed nothing nor any exceptional config modification sry). With other FPS games or anything else, I get no mouse wheel problems. On Q3 1.16, 1.32b, 1.32c neither
Another thing: I used a windows batch to increase my mouse polling to a fastest response time (I don't remember the value). At the moment, the test mouserate app comming with tells me it goes 125 Hz rate. Maybe this can be an issue. I read everywhere it doesn't hurt, but never read any decent argument for it.
In SetPoint is told:
- Control Center Version: 6.32.7
- Driver Version: 5.33.14
I can provide any other info to help troubleshooting this.
Thanks for support! And srsly, long long life to this game. CTF gameplay is freakin appealing, it can only get boring depending on the players involvment at the game moment, it's 1:1 relation between players/team skills and fun, so rare (--> unique yeah, not rare) perfect. And additionally, it's beautifull and run easy on low configs.
So yeah, let cryers and no-effort new comers leave it, but skill freaks, don't leave it. Whatever BF, whatever COD, that can be cool too yeah, but "this" is QL, the only fast game you enjoy when drunk or not. Play it a lot, play it a little, but don't abandon it. It's only the community duty to stand there. "Hey, come to my party ! There will be 1000 douches !" "Hmm, we're 8 and having tons of fun, why should this be bigger ?" Of course yes, let it pass away
SetPoint settings:
* - no mouse-to-keyboard binds (mouse5 works well on QL)
* - pointer settings:
*** - pointer speed: 6th/11 item selected on the horizontal bar
*** - pointer acceleration: none
*** - enable smart move: not ticked
*** - enabled pointer trails: not ticked
* - scrolling size:
*** - 3 lines (default setting, setting to 1 line brings a bad overall-mouse-usage behavior)
* - game detection:
*** - enabled: ticked
*** - apply game settings when a game is detected: ticked
* - game mode settings:
*** - keep mouse acceleration: ticked
*** - keep mouse speed: ticked
*** - keep right/left hand button assignments: ticked
*** - keep keypress button assignments: ticked
*** - keep other button assignments (double-click, autoscroll...): not ticked
* - speed and acceleration:
*** - setpoint implementation: ticked
*** - retain OS settings: ticked
*** - OS implementation: not ticked

subset: commoncrawl


text:
On Tuesday afternoon, the Borger Bulldogs took advantage of a great pitching performance by senior Hunter Hertel to open District 1-3A play with a 10-4 win over the Dalhart Golden Wolves on a cool afternoon at Huber Park.
Hertel dominated the Wolves' bats, striking out 13 while giving up just two runs on five hits in six innings of work.
The Wolves cracked the scoreboard first in the top of the third inning using three singles to bring in two runs to give Dalhart an 0-2 lead.
Borger responded in the bottom of the third as three Bulldog batters would be walked onto base, setting up Hertel to tie the game with a two RBI single. A passed ball at home plate allowed Garrett Irwin to come in from third to give Borger the one run lead before senior catcher Brandon Garcia hit a RBI single to make it a 4-2 score after three innings.
Over the next three innings, Hertel cruised on the mound by giving up just one hit while collecting five of his strikeouts during the span.
The Bulldogs extended their lead to 6-2 in the bottom of the fourth inning on a two RBI single by Max Lusk. This was followed with four more coming across the plate in the fifth inning that included a two RBI triple by senior rightfielder Zach McDonald.
Dalhart tried to rally in the top of the seventh inning by getting the bases loaded with no outs and scoring two runs. However, the Bulldog defense stepped up to hang on for the win with a double play at second and third base followed by Chayse Tracy closing out the game with a strikeout on the mound to give Borger the 10-4 win.
The Bulldogs improve to 10-9-1 overall on the season and start District 1-3A play 1-0.
The Bulldogs will next travel to Perryton on Saturday to take on the Rangers at 2:00 p.m. The Rangers lost their district opener with Pampa last night 3-1.
McDonald-2/3 1 triple 2 RBI's; Tracy-2/3; Lusk-1/2 2 RBI's.
Pitching-Hertel 6 innings 13 K's, 5 hits, 1 BB, 2 ER; Tracy 1 inning 1 K 1 hit 2 BB 2 ER.
Dalhart 002 000 2 4 6 3
Borger 004 240 0 10 7 1
[1] http://www.borgernewsherald.com/sites/default/files/bor base vs dalhart 12 pitching.jpg
[2] mailto:email@example.com
[3] http://www.borgernewsherald.com/category/sports/local-sports


text:
- 800.878.7323
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Used Trade Paper
Ships in 1 to 3 days
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The Photography Bookby Phaidon
Synopses & Reviews
Publisher Comments:
The ubiquity of camera phones today has made us all photographers, and as these nano-devices attest, the history of photography, perhaps more so than any other art, is also a history of technology, one best revealed in the very vehicle that makes it possibleand#151;the camera.
Through brief, illustrated chapters on fifty landmark cameras and the photographers who used them, Michael Pritchard offers an entertaining look at photography as practiced by professionals, artists, and amateurs. A History of Photography in Fifty Cameras is organized chronologically, beginning with William Henry Fox Talbotand#8217;s wooden and#147;Mousetrapand#8221; camera of 1835. Other entries include the Brownie (1900), the Coronet Midget (1935), the Kodak Instamatic 100 (1963), and, of course, the Polaroid SX-70 (1972). Photographs within each chapter show not only the cameras themselves but also samples of the images made with them. Pritchard uses each camera as a point of entry for talking about the people who used them and the kind of photos they produced, from Weegee and his Speed Graphic to Cartier-Bresson and the Leicaand#8217;s role in the invention of photojournalism. In the hands of individual photographers, he reveals, cameras came to represent unique styles of depiction.
Together, the stories of the fifty cameras gathered here present an approachable and informative take on a medium that continues to fire the imagination, whether weand#8217;re perfecting the selfie or longing for the days of Fotomat.
This is a mini edition of "The Photography Book", containing every sort of photography, from pictures of famous events such as the Royal Wedding and the first landing on the moon, to familiar shots by the masters of photography such as Bill Brandt and Henri Cartier-Bresson.
This book is a popular history of photography told through brief, illustrated chapters on fifty landmark cameras and the photographers who used them. The history of photography is in part a history of the cameras that moved the medium forward and gave photographers different ways of seeing and depicting the world. In the hands of certain photographersand#151;think of Weegee with his Speed Graphic or Robert Capa with his Leicaand#151;individual cameras created whole new visual styles.
and#160;and#160;and#160;and#160;and#160;and#160;and#160;and#160;and#160;and#160;and#160; For much of the cameraand#8217;s history, it was a mechanical device. By the 1950s, electrical control of shutters and exposure requiring a battery had increasingly became the norm. From the late 1970s, electronic and then computer control of camera functions were introduced to higher specified and more expensive cameras. The arrival of commercially viable digital cameras, which recorded an image on a CCD sensor rather than on film from the early 1980s, transformed the camera to a fully electronic device. By the mid-2000s, digital cameras were outselling film cameras, and in 2012 smartphone cameras were outselling digital cameras by a factor of six. The definition of what a camera was had changed as different electronic devices converged into one unit. The camera seems set for a further dramatic period of change in both its functionality and appearance.
and#160;and#160;and#160;and#160;and#160;and#160;and#160;and#160;and#160;and#160;and#160; A History of Photography in Fifty Cameras relates this story by selecting fifty key camera models and analyzing them in chronological order. The origin and development of each model is described in detail, along with its impact on both the art and science of photography.
This new mini edition of the bestselling "Photography Book" contains all the visual energy and compelling insights of the original, but in a light and truly portable format, making it ideal both for browsing through and using as a serious sourcebook. 500 images, 384 in color.
About the Author
Michael Pritchard was a photographic specialist at Christie's London for twenty years. He has been director general of the Royal Photographic Society since 2011.
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WOONSOCKET ŌĆö The numbers game was truly unkind to the Lincoln boysŌĆÖ swim team in its one-win campaign from a winter ago, and that was clearly evident in the final weeks of the season, when the Lions were forced to go into meets with just six swimmers at their disposal.
But this season, the numbers are high for the Lions, and so are their expectations at returning to their winning ways.
The Lions took a step toward that turnaround on Wednesday in their Division II season opener with Mount St. Charles at the Woonsocket YMCA. Sparked by senior Jason KimballŌĆÖs marvelous afternoon, the Lions were able to bus home with a 47-43 victory.
The news was also good on the girlsŌĆÖ side, as the Lions received a dominant meet from sophomore standout and returning All-Stater Mollie Westrick in securing a 47-44 triumph that wasnŌĆÖt as close as the final score indicated.
The Lions, who were 5-3 last winter (their first winning season in nine years), stormed out to a 47-21 command after eight events before Lincoln coach Tom DiIorio opted to swim the final three events as exhibitions.
The boys, meanwhile, erased a 16-10 deficit after three events to grab the top two places in the next two, the 50-yard freestyle and 100-yard butterfly, and claim a 24-18 lead that they never relinquished.
Once the Lions attained the 47-point mark that guaranteed them the victory, they also swam the final 400-yard freestyle relay as an exhibition, a courtesy they didnŌĆÖt have during last winterŌĆÖs 1-5 season.
ŌĆ£We have 16 boys this year,ŌĆØ reported DiIorio. ŌĆ£Last year, we only started out with 10 boys and ended up with six, and you canŌĆÖt do anything with six boys. You canŌĆÖt even have two relays.ŌĆØ
KimballŌĆÖs big meet included helping two of the LionsŌĆÖ relay teams claim victories. He swam the first leg on the 200 freestyle team, which included Ben Chiacchia, Andrew Hebert, and Cameron Kimball and won in a 1:45.83 time, and he joined those three swimmers as the anchor of the 200 medley relay that took first in 2:01.03.
Kimball also captured a pair of individual freestyle events, the 50 in 25.18 seconds and the 100 in 59.05.
Cameron Kimball scored eight points by claiming the 100 backstroke in 1:18.22 and finishing second in the 500 freestyle, losing a close battle to MountŌĆÖs Carl Ciullio, who won in a 6:11.41 time.
Hebert also produced a first-place finish in the 100 butterfly (1:05.01) and a second in the 50 freestyle, and Chiacchia added six points with runner-up finishes in the 200 individual medley and the 100 butterfly.
The Mounties were led by a multiple-victory meet by Ciullio, who also seized the 200 IM in 2:30.35 and anchored the 400 freestyle relay team of Greg Iovanel, Evan Giles, and Liam DeBeasi to a 4:26.34 victory.
The hosts also received victories from DeBeasi in the 100 breaststroke (1:18.89) and Iovanel in the 200 freestyle (2:25.25) and a pair of second place from Evan Giles in the 200 freestyle and 100 backstroke.
Westrick, who won state championships last year in the 100 butterfly and 100 backstroke, took care of business in the 100 butterfly and 200 freestyle, as she easily captured both events in times of 1:06.22 and 2:09.08.
She also swam the first leg on the victorious 200 medley relay team of Melissa Gianetti, Nicole Moneghan, and Liza Korotrova that produced a 2:09.15 time.
Emily Jacobson added a first in the 50 freestyle (29 seconds) and second in the 100 butterfly, and Casey Gagnon (100 freestyle, 1:05:7) and the 200 freestyle relay team of Angela Gagne, Gagnon, Gianetti, and Korotrova (2:00.3) also won events. Moneghan contributed runner-up finishes in the 200 IM and 500 freestyle.
ŌĆ£The girls were upset that their times were a little high,ŌĆØ admitted DiIorio. ŌĆ£I said, ŌĆśDonŌĆÖt worry about it. ItŌĆÖs the first meet. We only had two weeks of practice. What are you going to do?ŌĆÖ ŌĆØ
The Mounties were led by Elizabeth Gross, who won a pair of events, the 200 IM (2:25.83) and 500 freestyle (5:43.39), and anchored the 400 freestyle relay squad of Caitlin Barnabe, Sarah Gardella, and Catherine Sherman to a 4:42.61 triumph.
Judith Dayaw (100 backstroke, 1:23.69) and Lexa Lauzier (100 breaststroke, 1:29.35) also won events for the hosts.
Follow Eric Benevides on Twitter @EricBen24


text:
The Original Autostarts Manager. Keep control over your phone: See what applications do behind your back. I will show you all the apps that run automatically when you turn on your (...)
Loosely inspired by the traditional "Spin the Bottle", A World Of Photo is a fun casual, geo multiplayer online game with with a social touch. Update: Fixed Vibrate, 2.2 connection (...)
Whether you admire stunning photography, want to see breathtaking landscapes, or whether tiny kittens warm your heart - this puts an endless rotation of the internet's best images (...)


text:
- Northern New York Newspapers
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- NNY Business
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The U.S. Department of Agriculture announced that is issuing payments to dairy farmers enrolled in the Milk Income Loss Contract program for the September marketings.
The payment rate for September is approximately 59 cents per hundredweight. The payment rate for October marketings is 2 cents per hundredweight and the rate for November marketings is zero. Before the October MILC payment can be issued, farmers must complete a new Average Adjusted Gross Income form for 2013.
The American Taxpayer Relief Act of 2012 extended the authorization of the farm bill approved in 2008 through 2013 for many programs, including MILC.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
You can continue on to this article in a few seconds, or you can visit one of our websites:


text:
2 teens killed in Grandview crash, 1 in critical condition
Benton County Coroner John Hansens says Kevin Lopez-Gonzalez died at the scene. He was sitting in the front passenger seat and was wearing a seat belt.
Hansen says Carlos Ochoa died two hours later at Kadlec Regional Medical Center. Ochoa was thrown from the car. Hansens says it's not clear whether Ochoa was wearing a seat belt at this time.
The crash happened on Evans Road about three miles north of Grandview around 6 p.m. Tuesday. Deputies say the car was speeding when the driver lost control on a curve, went off the road and wound up in some trees.
The executive director of human resources for the Grandview School District confirmed the driver is 17-year-old Jovannie Razo. He is in the Intensive Care Unit at Kadlec Regional Medical Center in Richland. Benton County deputies say Razo is on life support.
Deputies say all three in the car went to Grandview High School. Additional grief counselors have been brought to the school today to work with the students.
Deputies say there is no evidence of drugs or alcohol. Speeding was a factor but they can't rule out a mechanical problem.
---Previous coverage---
BENTON COUNTY, Wash. -- Benton County sheriff's officers say two teenage boys were killed and another seriously injured in a one-car crash Tuesday evening about three miles north of Grandview.
Deputies say sometime after 6 p.m., the boys were speeding on Evans Road, north of Grandview when the driver lost control on a curve. The car rolled several times before coming to a rest in a clump of trees.
One boy was killed at the scene, another died at the hospital. The third was flown to a hospital.
Deputies said all three are Grandview High School students. Their names have not been released.
"We did have some witnesses to the accident so we were able to gather some information from the witnesses about what happened and therefore that's why we had decided that speed was one of the factors in this accident," said Kevin McCary, Benton County Patrol Sergeant.
This is a developing story and more details will be posted as they are available.


text:
Teacher Education
Whether you are returning for the final year of your Concurrent Education program or joining Brock for the Bachelor of Education program, we thought you could benefit from some additional information! If you have any questions after reviewing this information, you are welcome to contact us.
There are some major changes to OSAP this year, so be sure to check out our 2012-2013 OSAP Guide.
When you are completing your OSAP application, you will select "Bachelor of Education" for your program of study. This applies to students taking the 1 year Bachelor of Education program, as well as students that are in year 5 of the Concurrent Education program.
OSAP appeals
There are a number of OSAP appeals that may increase the amount of OSAP funding you are eligible for. You can view the most common OSAP appeals on the OSAP Forms page.
Many Bachelor of Education students will qualify for the "Request for Review: Vehicle Exemption Level" appeal as a vehicle is required to attend placements. The "Request for Review: Adjust Local Travel" appeal is also common among Bachelor of Education students that are commuting.
Brock University offers numerous bursaries for students demonstrating financial need. The "Awards and Bursary Application" will be available online beginning August 1st for the 2012-2013 academic year. By submitting the single application, you will be considered for all Brock and donor bursaries.
Temporary Disruptions
The Student Awards and Financial Aid office will be closed on Labour Day Monday, September 7th.


text: Just got this from my local UUG and thought some of you might find it useful/informational. Free course on Solaris 10, and a free PS2 when you sign up for a sun cert. I believe the PS2 offer is only available in the US and Canada, so read the small print. I know the promos are pretty lame but if you're looking for a SUN cert might as well get PS2 in the process. 8)


text:
The children of King George V
1 portrait of Prince George, Duke of Kent
© National Portrait Gallery, London
The children of King George V
by W. & D. Downey
vintage print, circa 1909
5 1/4 in. x 3 7/8 in. (133 mm x 98 mm) overall
Photographs Collection
NPG x136043
Click on the links below to find out more:
Artistback to top
- W. & D. Downey (active 1855-1940). Artist associated with 886 portraits.
Sittersback to top
- Prince Edward, Duke of Windsor (King Edward VIII) (1894-1972), Reigned 1936. Sitter associated with 400 portraits.
- King George VI (1895-1952), Reigned 1936-52. Sitter associated with 497 portraits.
- Prince George, Duke of Kent (1902-1942), Naval and air force officer; son of King George V. Sitter in 162 portraits.
- Prince Henry, Duke of Gloucester (1900-1974), Son of George V. Sitter in 178 portraits.
- Prince John (1905-1919), Youngest son of George V. Sitter in 29 portraits.
- Princess Mary, Countess of Harewood (1897-1965), Princess Royal; daughter of George V. Sitter in 266 portraits.
Subjects & Themesback to top
Tell us moreback to top
Can you tell us more about this portrait? Spotted an error, something missing, or do you know anything that we don't know? If you have any information to share please complete the form below
Exhibitions and displays
- Curators' Choice: Photographs from the Terence Pepper Gift
Until 24 January 2016
- Women and the First World War
Until 25 October
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