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Piedras Suites
A hip hide away offering a laid back atmosphere and incredible hospitality.
Among the architectural highlights are high ceilings, Oversized windows, from floor to ceiling (with blackout curtains), a fully equipped kitchen and a mezzanine that overlooks the main area.
Your satisfaction is our highest goal. Our commitment is to care for every detail of your stay.
As frequent travellers, we believe in the balance between quality and price. We know vacation is the best time of the year! All has to happen as planned!
Well help you find out those secrets of this city which will allow you to reach a different experience from your travel.
Please Note:
Check in time 2.00 pm
Check out time 11.00 am
Cancellation Policy: 72 hours; late cancellations and no shows will be charged the amount of the first night
Availability & RatesTo view availability and prices please select dates and click 'Update Dates'
Hotel Facilities & Policies
- 24 hour reception
- 24 hour security
- Adaptors
- Air Conditioning
- Airport transfers
- Bicycle hire
- Book exchange
- Breakfast Included
- Cable TV
- Ceiling fan
- Child Friendly
- Cots available
- Direct dial telephone
- DVDs
- Elevator
- Fax Service
- Free City Maps
- Free Wifi
- Hair Dryers
- House Keeping
- Internet Access
- Luggage Storage
- Meeting Room
- Non Smoking
- Outdoor Terrace
- Reading Light
- Safety Deposit Box
- Taxes included
- Tea/Coffee Making Facilities
- Tours/Travel Desk
Cancellation PolicyThis property has a 3 day cancellation policy. Failure to cancel within this time will result in a cancellation charge equal to the first night of your stay.
Must-Read Hotel InfoThis property has specific Terms & Conditions.
Please note that due to new regulations with Visa & Mastercard this hostel requires the 3 digit security from the back of your credit card! Please contact us if you have any questions.
Special Events Year 2014
For all reservations made for at least one of the following dates, the special policies and booking conditions will apply:
October 10th until 12th Holiday in Argentina "Día del Respeto a la Diversidad Cultural"
November 21st until 23rd Holiday in Argentina "Día de la Soberanía Nacional"
December 31st until January 3rd 2015 Holiday in Argentina New Year
Special Events Year 2015
For all reservations made for at least one of the following dates, the special policies and booking conditions will apply:
February 2nd until February 17th CARNIVAL 2014
March 20th until March 24th Holiday in Argentina "Día de la Memoria, la Verdad y la Justicia"
April 2nd until April 5th Holiday in Argentina EASTER WEEK
May 1st until May 3rd Holiday in Argentina LABOUR DAY
May 22nd until May 25th Holiday in Argentina "Revolución de Mayo"
· The hotel will charge 10% of total reservation as deposit when receiving the booking. This is Non Refundable. If this transaction is not permitted, the reservation can be cancelled by hotel.
· Cancellation up to 7 days before check in date (2pm): 10% of total reservation charge
· Cancellation out of term or no show: the hotel will charge total amount of reservation
DirectionsShow MapHide Map
Just 2 blocks from Av 9 de Julio subway.
Driving directions from Aeroparque Jorge Newbery:
1. Head east toward Av Rafael Obligado Costanera 39 m
2. Slight right onto Av Rafael Obligado Costanera 1.8 km
3. Slight right onto Jernimo Salguero 300 m
4. Take the ramp onto Pte. Arturo Illia
Partial toll road3.5 km
5. Continue onto Av 9 de Julio
850 m
6. Turn right onto Av Crdoba
39 m
7. Take the 1st left onto Cerrito
1.0 km
8. Continue onto Lima
1.5 km
9. Turn left onto Av San Juan
400 m
10. Turn left at the 3rd cross street onto Piedras
Destination will be on the right 400 m
Piedras 906
Ciudad Autnoma de Buenos Aires, Argentina
Located Near
San Telmo pulses the cultural and bohemian life of the city. A colorful and multi-cultural neighborhood, located in the very center of Buenos Aires; steps away from downtown and in perfect contrast with the more modern urban developement of Puerto Madero.
You will find yourself in an architectural paradise, suspended in time; a place in which the new and the old blend into a unique and unmistakable style


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Football fans walk on the crest of the Westside stands before the game with Greenwood.
The Westside Army JROTC warm up before pregame color guard participation.
Westside cheerleaders sway to the music of the alma mater before the game with Greenwood.
Tommy Drake scores his second goal of the game.
Bo Godwin
Cody Mizell
Wes Nelson
Tommy Drake
Westside coach Ted Luckadoo talks with Greenwood coach Gene Cathcart before the game.
Greenwood coach Gene Cathcart talks with Westside coach Ted Luckadoo before the game.
Greenwood quarterback DJ Dunlap runs seven yards for the third touchdown of the game against Westside.
Greenwood quarterback D.J. Dunlap runs while Westside defender Jonathon Jeffery pulls on his jersey in the second quarter.
Greenwood receiver Rod Watson runs past Westside defenders in the second quarter.
Greenwood running back Devante Parks points as he scores past Westside defender Rocky Jones in the second quarter. Greenwood led 28-0 at the half.
Greenwood quarterback DJ Dunlap runs 68-yards for the first touchdown of the game against Westside.
Westside Rams Marching Band enter the stadium before kickoff.
Westside Rams Marching Band perform at halftime.
Westside Rams Marching Band play the National Anthem.

subset: commoncrawl


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The Amish are a Christian church that traces its roots to the Protestant Reformation in sixteenth-century Europe. Amish people accept basic Christian beliefs but also have some special interpretations and emphases that have emerged throughout their history. They migrated from Europe to North America in the eighteenth and nineteenth centuries. No Amish remain in Europe. Today they live in 480 geographical settlements in 30 states and the Canadian province of Ontario. Their population (adults and children) totals approximately 290,100. Their unique practices make them one of Americas most interesting and colorful religious subcultures.
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This site is maintained by the Young Center for Anabaptist & Pietist Studies, Elizabethtown College. © 2014 Elizabethtown College. All rights reserved.


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South Pole
Would you believe there are actually three different South Poles? In this BrainPOP movie, Tim and Moby introduce you to life at the bottom of the world. You'll learn about three different South Poles, and why there are so many. Discover some fun facts about the continent on which the South Pole is located, including how long the winters last, how cold it gets, and why there's no sun for six months! You'll also learn what kind of animals and plants can tolerate these harsh conditions, why the continent has no permanent residents, and how it's governed. Bundle up — it's going to be a cold trip!
Learn More:What are the magnetic poles?Who owns the North and South Pole? What is polar shift?
See a Full List of Topics


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|Cool 5 Activities Start Today on Beech
|Written by Steve Frank
|Friday, 11 June 2010 05:59
A cool time in Beech Mountain this weekend, with the Cool 5 race set for tomorrow.
But the runners are expected to gather tonight for their pre-race pasta meal, kicking off the event. There will be live music, games, and other activities at Buckeye Recreation Center. Registration goes on all day today, then the meal starts at 5:30, and Saturday's events crank up at 7am—the five mile race at 9am, 9:15 for the mile-and-a half event. Post race activities will continue much of the day tomorrow in and around the Rec Center and through Beech Mountain.
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Health Behaviors in School-Age Children: A World Health Organization Cross-National Study
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study is a survey (Health Behaviors in School-age Children) sponsored by the World Health Organization to gather information about nutrition, dieting practices, physical activity, injuries, violence, relationships with family and friends, perceptions of school as a supportive environment, alcohol and tobacco use and drug use among adolescents, and about the communities in which students live. The U.S. sponsors of the survey are the National Institutes of Health and the Health Resources and Services Administration.
The objectives of the international HBSC study are:
- To assess the prevalence of early adolescent health behaviors
- To identify psychosocial factors associated with adolescent behaviors
- To provide an opportunity for analyses of cross-national comparisons
- To provide an opportunity for analyses of trends in the U.S. and cross-nationally
In addition to the above, the survey includes additional questions designed to provide information about areas of specific national interest, including the following:
- To assess the association of school, family, peers, and other environmental factors on health behavior and health status
- To assess the prevalence and identify factors associated with diet and physical activity
- To assess the prevalence and identify factors associated with bullying and risk behaviors.
This is the third U.S. administration of the HBSC survey, previously administered in 1997-1998 and 2001-2002.
U.S. participants in the survey include about 15,000 students from 350 schools selected to take part across the country. In each school, one or two classes (about 25 students) in each grade 6 through 10 are picked randomly to participate. In one class period, the students complete the written survey, which has 80 multiple choice questions. Students do not put their name on the survey. When they finish the survey, the place it in an envelope and seal it shut. The envelopes are then put in a box. Reports will not include the names of participating counties, cities, school districts, schools, or students.
The information collected from U.S. school children is compared with similar information collected from school children in 36 other countries. The survey is used to help set national priorities for school and youth programs, as well as to monitor the progress of these programs.
Health Behavior
|Study Type:
|Official Title:
|U.S. Health Behavior in School Children Survey
|Estimated Enrollment:
|Study Start Date:
|October 2005
|Estimated Study Completion Date:
|November 2006
The Health Behaviors in School-age Children (HBSC) survey is the only international survey of its type and the only national survey of adolescent health behavior in the U.S. The U.S. HBSC complements the Youth Risk Behavior Survey (YRBS) and the Monitoring the Future surveys of older adolescents. The aims of the survey are to assess the prevalence of health behaviors and identify factors associated with them in a national probability sample of 6th -10th grade students, allowing for trend analyses and cross-national comparisons among the 37 countries involved in the quadrennial international HBSC surveys. This would be the third U.S. administration of the HBSC survey, previously administered in 1997-1998 and 2001-2002.
|Ages Eligible for Study:
|7 Years to 16 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
6th and 10th grade students
Please refer to this study by its ClinicalTrials.gov identifier: NCT00341510
|United States, Maryland
|National Institute of Child Health and Human Development (NICHD)
|Bethesda, Maryland, United States, 20892
|ClinicalTrials.gov Identifier:
|NCT00341510 History of Changes
|Other Study ID Numbers:
|Study First Received:
|June 19, 2006
|Last Updated:
|March 5, 2008
|Health Authority:
|United States: Federal Government
Keywords provided by National Institutes of Health Clinical Center (CC):
Risk Behavior
Health Status
Positive Health Behaviors
Social Support
Health Behavior
ClinicalTrials.gov processed this record on October 13, 2015


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After taking three of four games from Colorado Northwestern Community College in mid-March, the Eagles have backtracked and watched as their losing streak reached a season-high eight games, including a four-game sweep at the hands of College of Southern Nevada over the weekend.
CSN took the sweep thanks to wins of 8-4 and 17-6 on Friday and 6-0 and 10-3 wins on Saturday.
USU Eastern (11-23, 3-17 SWAC) will travel to Twin Falls, Idaho for a four-game series with College of Southern Idaho starting on Friday.
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Photographing American Modern: Hopper to O'Keeffe
Tuesday, November 12, 2013, 11:30 a.m.
Special Exhibitions Gallery, second floor
Related Publications
Wyeth: Christina's World
Laura Hoptman
American Modern: Hopper to O'Keeffe
Esther Adler and Kathy Curry
More info at MoMAstore.org »
Add Hardcover to cart ($45.00 / $36.00 Members) »
During the first half of the 20th century, American artists expanded the notion of what a photograph could capture. We will focus on the photographic works on view in American Modern: Hopper to O'Keeffe and then make our own still lifes, portraits, landscapes, and abstractions. Please bring your cell phone cameras and digital cameras.
In conjunction with the exhibition American Modern: Hopper to O'Keeffe
Gallery Sessions, impromptu interactions facilitated by Museum educators that explore the creative process, art history, and the experience of art, take place daily in select galleries. Groups meet in the galleries noted on the schedule. Gallery Sessions are free with Museum admission. No registration is required.
FM headsets for sound amplification are available for all talks.


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A wounded warrior goes back to work
COMBAT OUTPOST SEMINOLE, Afghanistan - The Marines prepare for today's mission slated for 1300, the most miserable part of the day.
The sun is bright, glaring like some malicious, evil force. Beads of sweat trickle into my eyes as I heave my armor over my head and guzzle several bottles of water.
"Why are we going out on patrol in the heat of the day?" I ask to no one in particular. The Marines just shrug; they just do what they are told, without complaint. | Photo Gallery
We start off over a large field of over turned soil that is sun baked into huge chunks of rock like formations. The front of my boots flex on the tough ground as I try not to stumble.
Someone says its 97 degrees out, but it feels like 120 degrees. In fact a Marine claims it's a cool one today.
After the field we reach irrigation ditches reaching down some five to ten feet.
The Marine ahead of me leaps over each one without hesitation. I take my time and each time count myself lucky that I didn't fall and break my leg.
The next portion of the course is a flat plain of mud, about ankle deep with foliage of some kind of dying green plants up to our shoulders. The sweat drips into my eyes like some kind of acid rain. I wipe away the drops, with fingers covered in dust.
But I don't complain because the Marine in front of me walks with his head up, lugging a huge backpack and a hefty M4.
This is LCpl Daniel Halek's second patrol since he was shot in the right arm on Aug. 12, 2010.
Halek and the men in 3rd Platoon, based out of Combat Outpost Seminole, are on patrol to relieve Marines from another company in a smaller outpost. "They're waiting for relief," says Halek. Some of the men have been at the outpost for two months.
For Halek the patrol marks his official return to duty. Just 17 days ago he was medevacked to Dwyer (a larger base with higher levels of medical care), where medical staff attended to his wound, which did not even require stitches.
He stayed with the wounded warriors, which refers to wounded Marines in the area, for just over a week.
"You sit there and you're just ready to come back. You talk to everybody's families and they know they're all going on patrols and you're stuck in Dwyer wanting to go out with them," he says. "You don't really know what's going on the whole time you're there. So you go pretty crazy."
According to most Marines there is nothing worse than having time on their hands.
Although his wound is still healing, Halek is right where he wants to be, out in the sun slogging through the obstacle course of Afghanistan's terrain.
"I'm feeling good now that I'm back," says Halek. "I've been dying to come on patrols."
For his first week back at Seminole with his fellow Marines, Halek was put on light duty, which means staying on base.
"You fight with everybody, stay with everybody in combat," says Halek.
Dan Morrison and Cali Bagby are embedded with the Marines in Helmand province, Afghanistan, north of the Pakistani border, as multimedia journalists for KVAL News.
Morrison teaches photojournalism and multimedia reporting at the University of Oregon School of Journalism and Communication in Eugene, Ore.
Bagby is a freelance multimedia journalist who spent 10 months embedded with the Oregon National Guard in Iraq for KVAL.com.


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42 U.S. Code § 1862f - Research center consortia
Source(Pub. L. 100–570, title I, § 110,Oct. 31, 1988, 102 Stat. 2869.)
Section was enacted as part of the National Science Foundation Authorization Act of 1988, and not as part of the National Science Foundation Act of 1950 which comprises this chapter.
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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Photograph of Drop City dome. Courtesy: 7th Art.
"This dome feels gooood!" So proclaimed the mellow, avuncular Clark Richert on a breezy early summer evening at the MoMA PS1 Dome in Rockaway Beach, Queens. Richert is one of the world's experts on dome vibes: he was co-founder of the Drop City community in southeastern Colorado that constructed fanciful geodesic structures out of improvised materials in the mid-to-late 1960s. He and Richard Kallweit, another Drop City founder, were on site to discuss the eponymous film about the collective, which had its NYC premiere in Rockaway on June 21 (the PS1 dome opened in March and was dismantled in late June). Directed by Joan Grossman, the feature-length documentary probed the history and legacy of the seven-year experiment in communal living in which members, in pioneering proto-environmentalist fashion, lived on their neighbor's castoffs while hunting for car tops and construction materials in dumps and scrapyards from which to build domes of various kinds around their communally-owned property.


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J.R. Smith Arrested in Miami
Miami Beach police say New York Knicks guard J.R. Smith has been arrested on a bench warrant for not having a valid driver's license.
Sgt. Bobby Hernandez says 26-year-old Smith was stopped Thursday night on Washington Avenue in South Beach. A routine search revealed the bench warrant and he was arrested.
At least he didn't tweet about it.


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Video: Seat Cover
Product Test: Pet Rider Seat Cover
If you want to take your pooch for a cruise, but don't want to get your car all dirty, this product may help.
It is the Pet Rider and they're for sale at petrider.com. You get two for ten dollars, plus shipping. It is durable and well made. It is also easy to put in and take out. It goes in the washing machine, too.
Our tester, Andrew gave it two thumbs up.


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Tri-Aktiline Plus Deep Wrinkle Filler + Firming Concentrate
The silky, fragrance-free formula provides a dose of antioxidants, and it comes in packaging that will keep them stable.
Tri-Aktiline Total Face Instant Line Reducing Moisturizer
This moisturizer has what it takes to promote and maintain healthier skin and does so without adding fragrance.
Add to Faves?
GoodSkin Labs At-A-Glance
Strengths: Most of the serums and treatment products (including the wrinkle fillers) are very good; relatively inexpensive given the anti-aging ingredients used; some of the products are fragrance-free.
Weaknesses: Falls short in terms of not offering any sun protection products; no longer a comprehensive line.
GoodSkin Labs is owned by Estee Lauder and sold exclusively at Kohl's department stores. Although originally launched as a full-featured collection of skin-care products, the brand has since been whittled down to a few key players. We're not sure why the downsizing occurred, but perhaps it's Lauder simply decided to focus on the core products that sold best. Whatever the reason, what remains from GoodSkin is a mixed bag—but there are some very good products you may want to consider. Because this is Lauder-owned line, you'll find several products are similar to others from Laude brands, including Clinique. The price point of GoodSkin Labs is in line with Clinique, though with Clinique you have a lot more choices and can, if desired, put together an entire skin-care routine. Just to be clear, you can put together a brilliant skin-care routine with products from different brands—let go of the myth that you won't get good results if your routine mixes and matches various brands. In some cases that may work beautifully, but more often than not it can lead to trouble because few lines offer a perfectly ideal assortment of products. What GoodSkin Labs does best is serums and anti-aging treatment products (including wrinkle fillers) and most of them are fragrance-free. Their formulas combine proven beneficial ingredients in elegant textures and packaging that helps keep light- and air-sensitive ingredients stable during use. As with most cosmetic lines, the claims are a bit over the top, but for the most part the formulas contain an impressive range of ingredients that can help your skin look and act younger. You won't find anything here that Estee Lauder's namesake brand isn't also offering, but if you routinely shop at Kohl's, there are some products that are worthy of checking out! For more information about GoodSkin Labs, visit www.goodskinlabs.com.
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Montage of historical footage from Denmark. Bicycle related, duh.
21 September 2011
Danish Bicycle History
Montage of historical footage from Denmark. Bicycle related, duh.
8 comments:
what is the music?
- 01:38
- Peter said...
Such beautiful images and you can see the car hardly anywhere.
- 01:40
- Stefan Ertmann said...
@Anonymous - I'm not sure what the song is called, buts its lifted from the Poul Henningsen movie 'Danmark' released in 1935.
- 09:52
- shuichi said...
How nostalgic both the music and the figures are! I noticed that some people seated their children on the frame while riding their bikes. I sometimes do the same thing while riding my mountain bike. To tell the truth it is not so dangerous. Kids are always happy. Thank you.
- 15:02
- amoeba said...
There are a number scenes, e.g. at 1.08 where seemingly hundreds of people on bikes are moving smoothly. One doesn't need much imagination what would happen on a similar sized road were they all driving cars, given typical car occupancy figures.
Writing from car-clogged Greater London, our much-vaunted 'progress', isn't what it's cracked-up to be.
But of course, bicycles slow down cars and cause traffic-jams, except that this just isn't true, despite being repeatedly claimed by petrol-heads.
BTW. Lovely compilation of clips.
- 20:28
- amoeba said...
Re: shuichi and childhood happiness,
Netherlands, Sweden, Denmark and Finland are the top four countries for child well-being, and shamefully, the UK languishes in 21st place out of twenty-one, behind the USA. As David Hembrow pointed-out, those first four countries are also the top four for cycling.
Reference: UNICEF - 'An overview of child well-being in rich countries'
- 20:31
- tstreet said...
Bikes are paradise.
- 02:26
- Diana Sesarin said...
great pictures
- 14:45


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Forrest Q. Friesen
Lithium wall conditioning and surface dust detection on NSTX
Physica Scripta (2011)
Techniques for injection of pre-characterized dust into the scrape-off layer of fusion plasma
Fusion Engineering and Design (2011)
Evaluation of an electrostatic dust removal system with potential application in next-step fusion devices
Review of Scientific Instruments (2011)
I offer private tutoring for students taking physics courses, and have 5 semesters of physics teaching experience between my time at Duke University and Grinnell College.
My teaching pedagogy focuses on improving intuition for the relevant concepts, which can then be used to build up understanding of the underlying mathematics. Learning physics presents unique challenges, especially for first-time students. However, anyone can tackle these difficulties with an approach that works for them, and enjoy the equally unique satisfaction of better understanding the mechanisms of universe. Please feel free to send me an email for rate and scheduling inquiries.


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- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
POTSDAM - Clarkson Universitys Facebook page hit a milestone in April by surpassing 10,000 followers.
The university began the page several years ago as part of its engagement efforts. Since then, it has turned into a virtual town square for prospective and current students, alumni, family, community members and anyone else interested in Clarkson to connect with the university and each other.
The Facebook page (www.facebook.com/ClarksonUniversity) features news, achievements and profiles of Clarkson faculty, students and alumni. It also promotes upcoming Clarkson events and shares photos from those events and candid pictures of campus life.
Clarkson interacts with its Facebook followers in multiple ways, such as an alumni question of the week meant to provide current and prospective students with advice, Clarkson trivia questions and vintage photos from the University, Potsdam and old yearbooks.
Clarkson defies convention as a technological institution with a highly collaborative community. We use Internet-based technologies to share information, as well as authentically engage our audiences in the Clarkson experience, whether it be the 17-year-old prospective student, a Clarkson sophomore, parents or our alumni, said Kelly O. Chezum, vice president for external relations. Social media expand the opportunities we have to seamlessly connect and engage the Clarkson community in ways that simply were not possible a decade ago.
Clarksons Twitter account, @ClarksonUniv, also hit a milestone in late March by surpassing 5,000 followers. The University also ramped up its Instagram account, @ClarksonUniv, over the last year.
Clarkson is also finding new ways to engage on social media, such as sponsoring a Best of Clarkson Instagram photo contest in February for students and encouraging hockey fans to Tweet at Cheel Arena games for a chance to get their message on the scoreboard.
Numerous departments within the university have also established a social media presence of their own, including the Office of Student Life, the Department of Electrical & Computer Engineering, the Reh Center for Entrepreneurship and the Career Center.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
You can continue on to this article in a few seconds, or you can visit one of our websites:


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On Sept. 21, Delta County Sheriff's Office Deputies Daniel Abeyta, Kevin Ray and Travis Lackey responded to a single vehicle accident in the 2100 block of State Highway 348. The accident was reported to dispatch by Larry Proctor, who was passing by and saw the vehicle in the ditch.
Deputies hailed for rescue from submerged vehicle 2131 views
Wish granted for Delta 9-year-old and his family 506 views
Nine-year-old Jeremiah Hitzfelder was recently granted a dream trip to visit the Walt Disney World Resort in Orlando, Fla.
Jeremiah's trip was granted by the Sunshine Foundation, which answers the dreams of children living with lifelong chronic illnesses, physical challenges, or the trauma of abuse.
Another round of layoffs hits mines 371 views
The announcement of layoffs at Bowie Mine #2 on Sept. 29 by its wholly-owned subsidiary, Bowie Resources LLC (BRP), is expected to have lasting negative impacts on Delta County's economy.
BRP will lay off 78 full-time positions and eliminate 19 contractors as part of its efforts to scale back production of its Bowie #2 mine at Somerset "as a result of idling its longwall while it develops a new longwall panel and continues to evaluate the market for Bowie #2 coal," according to a press release. Development of the new longwall panel is expected to take 12 months.
Former DPD chief received $50,000 severance payment 284 views
After written Colorado Open Records Act (CORA) requests, the City of Delta has disclosed Robert Thomas received a $50,000 severance payment upon his retirement as police chief.
The city initially refused to disclose that information, citing "personnel" issues, but city attorney David McConaughy agreed the payment is public information.
Chicken barn OK'd 268 views
The Board of County Commissioners on Monday approved the specific development application for Kurtz Chicken Ranch on Redlands Mesa.
Approval came on a 3-0 vote.


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Report Says China Has Most Staffing Firms
Which country has the most private employment agencies?
It's China, according to new research by Ciett, the International Confederation of Private Employment Agencies.
China has the most private employment agencies at 49,000 in 2010, according to the report. That's more than the three next-largest countries combined — Japan has 20,000 private employment agencies, the U.S. has 13,900 and the U.K. has 11,500.
Ciett's numbers may not always agree with those of other sources, however. Two other sources, the U.S. Bureau of Labor Statistics and the U.S. Census, even differ in U.S. counts.
Nevertheless, according to Ciett, there are 128,000 private employment agencies in the world based on data from 37 countries. Places that didn't appear on the list included large countries such as India and Russia.
It's surprising China has so many agencies. In the same report last year, Ciett didn't list the number of Chinese employment agencies. And the sheer number of agencies in China also raises questions: How is a private employment agency defined in China? What does the average Chinese staffing firm look like? What types of workers do they place? The report didn't have information on the number of contingent workers that China has.
Regardless, if there really are 49,000 agencies in China, we will no doubt be hearing more about the staffing industry in that country.
To go to the Ciett website for the full report, click here.


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Nicole Forsgren-Velasquez Receives NASA Funding - June 2013
Nicole Foregren-Velasquez, new faculty member with a joint appointment in the School of Accountancy and Management Information Systems departments, recently learned that her proposal to study knowledge management at NASA has received approval and funding in the amount of $15,000. This research engagement will investigate the use and impacts of knowledge management systems by system administrators, and recommend future directions for development and implementation. This is a particularly interesting project because the different NASA sites have drastically different cultures and norms. Outcomes of this project will include full academic publishing rights. The project will be completed over the summer.


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With the release of the Unlocked iPhone 4 everyone was intrigued by the numerous additional features inbuilt into it. While the official date for the release of the iPhone 4 has been set for June 24 by Apple, the price for the 16GB iPhone 4 is set at $199 while the 32GB version of the iPhone 4 will cost around $299, should you decide to go in for the upgrade offers. Available in two colors, white and black, the iPhone 4 is sure to set records on its release date of 24th June. On the downside, due to production of the iPhone 4, the manufacture of the iPhone 3 has been discontinued while the price of the iPhone 3GS has been reduced to $99 for the 8GB device.
Along with unveiling the iPhone 4, Apple also announced that the latest version of its operating system, the iOS4.0 will be made available for all users from 21st June onward. This latest release of the OS will be made available to all iPhones free of cost. In the same vein, AT&T has also announced that current subscribers of theirs currently having plans ending in 2010 would be able to upgrade to the iPhone 4 at a cost of $199 or $299, depending on the memory capacity they need.
With the release of the iPhone 4, Apple has been able to cement its place in world markets as a global leader in the development of unlocked smartphones. One prominent feature of the iPhone 4 is its using of a gyroscope, GPS and accelerator. According to Apple, this is meant to benefit users of the iPhone for gaming. Because of these new implementations by Apple, the device can register six-axis movement, allowing users a much more vivid gaming experience. At the same time, there is also an improvement in the camera capabilities of the iPhone 4. The current version of the iPhone has a camera with 5MP as compared to previous versions using just 3MP cameras.


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Practice Management of Common Medical Problems
November 24th & 25th, 2006
Saskatoon, Saskatchewanby K.C. Giede
Note: the following pages include Real Video presentations. Click here to download and install the Real Player if you do not have it already.
by K.C. Giede
If you are experiencing difficulties while browsing or navigating the CME website, please contact the CME webmaster


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With gold bouncing up from $1,668 an ounce on Friday, August 5 to $1,778 on Tuesday, August 9, it was the biggest three-day rally since the start of the great recession in 2008. At the same time, the equities markets were falling precipitously, losing over 600 points on the Dow on Monday alone. What is the connection?
The easy answer is fear, loss of confidence, and uncertainty. A credit rating agency has taken away the United States' top-tier AAA rating on its bonds, the spreading debt crisis in the Eurozone has now reached Italy and Spain, and the assumptions tying the financial system together are beginning to be questioned. In its report entitled "On the Coming Gold War," Redburn Partners says a "rising gold price is a warning signal: it casts doubt on the US economy…. Gold is the only asset to outperform in periods of either uncontrollable inflation or deflation: the US economy is on the knife-edge between the two … gold is a vital barometer."
Click here to read the entire article.


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Undergraduate Magazine
Growing Our Global Family
A growing number of students, welcomed to campus every year as part of The University of Alabama family, are enthusiastically joining UA's global family by taking part in international programs to study, travel and work in different countries around the world.
French Press
Spending days on the French Riviera and evenings in fine Parisian restaurants sounds like a dream vacation for most. But for 20 University of Alabama students, it was all in a day's work.
Touching Lives Through Service
They traveled to Peru to improve drinking water and waste water systems in two villages. They significantly improved plumbing in several homes and restored an old baseball field in Hale County, Ala. They studied residential water sources in Cambodia as part of an ongoing quest to boost their quality.
A Traveling Tribute
According to late UA history professor John Ramsey— one of the most legendary, admired figures ever to teach at the University—the best way to appreciate the Old World foundation of our culture was to see its birthplace firsthand. Known for his boundless generosity and love of helping others, Dr. Ramsey served as a mentor to several generations of students during his 42 years on campus, which included advising (and even, in some cases, financing) overseas trips so students could view for themselves the places they'd discussed in his classes. And today, the University's John Fraser Ramsey Award preserves that legacy for a handful of outstanding undergraduates.
Getting the Green Light
To understand the environmental stewardship that Icelanders practice, you have to get out and live it: Take a hike. Plant a tree. Build a sod house. Work in a greenhouse. Live on a farm. That's Dr. Michael K. Steinberg's philosophy, and that's also why he led a group of UA students to the island nation in May.
Hand in Hand With History
For Laura Dover, one memory perfectly captures the enchantment of her summer 2008 semester at England's Oxford University. Having studied Matthew Arnold's famed 1853 poem "The Scholar-Gipsy" in class, she and a group of other students ventured out to explore the nearby Cumnor Hills amid which the poem is set.
Returning to His Roots
Andrew Gibbs isn't your average University of Alabama senior. At 25, the Huntsville resident is a little older than most of his classmates. He was born in South Korea and adopted as an infant by an Alabama couple. And last year, thanks to a three-and-a-half-year hitch in the U.S. Coast Guard and a Benjamin A. Gilman International Scholarship, Gibbs finally got the chance to connect with his birth country.
A World-Class Experience
Alana Smith had high expectations for her student teaching experience in Ireland, but she had no idea that it would change the course of her career.
A Cultural Connection
In June 2009, Lauren Masters found herself standing before a bunch of eager faces in a bare-bones classroom in Sunyani, the capital city of Ghana's Brong Ahafo region. She was teaching a class of teenagers about President Obama, who was soon to visit the West African nation, but she was learning a lot, too.
Puertas Abiertas, Mentes Abiertas
Studying for a semester in Cuba proved to be an eye-opening experience for a group of University of Alabama students. Although they came in with varied sets of expectations, they unanimously agree that they found the people of the island nation warm and welcoming.
Stretching the Boundaries
No two students in UA's International Honors Program (IHP) have exactly the same interests and ambitions. But they all have one thing in common: an appetite for adventure and exposure to new ideas.


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NEWPORT–The sight after the game of an exhausted Paul Samaan laying on the ground, inhaler in hand, summed up the effort that the UCA boys gave in their tough-luck 1-0 loss to West Rutland Tuesday afternoon in the opening round of the Division IV soccer play-offs.
"The boys gave everything they had today, but you still hate to lose a game like this 1-0," said coach Alyssa DeLaBruere.
UCA matched their opponents step for step, chance for chance, but in the end a squibbler that got past Chris DeLaBruere decided the contest.
In the early going West Rutland and the Crusaders traded opportunities.
Ji Kim and Jon DeLaBruere were in the thick of the offensive action all afternoon, and it was Jon's attempt on goal that nearly put UCA up 1-0.
Ji took the ball down the right side of the pitch, fed it over DeLaBruere, but keeper Josh Smith had the angle on the ball.
For the visitor's, Dennis Phillips' tip of a free kick nearly made it in, but it went just wide.
Phillips was a bit of an attraction during the game, entertaining West Rutland's fans all afternoon with his long distance flip throws.
25:00 minutes into the half, West Rutland was awarded a penalty kick and Brandon Groh lined up at the six to take the shot.
He fired low to the left hand side, looking to squeeze one inside the post, but Chris dove and made a spectacular stop to keep it out.
But a minute and a half later, Groh scored on a partial breakaway to give the green and yellow the lead.
A long free kick bounced over the Crusader defenders, and Groh took off with the ball.
Sang Mo Kang made a herculean effort to get back, almost catching the West Rutland forward, but Groh got the shot off just in time and it found a crack and went in.
Groh almost did it again, but Samaan hustled back to strip him of the ball.
Marc Quirion nearly tied the match on a direct, but Smith leaped and punched the ball over the cross bar.
Ji had the last chance of the half for UCA, but was denied in his quest.
In the second, the play only improved for the Crusaders.
Jon and Ji hooked up again, this time with Kim taking the shot, but it sailed wide.
DeLaBruere then sent in a bomb that was stopped, and Kim struck the ball wide again, and the frustration and the desperation were starting to mount.
"We certainly created tons of opportunities in the second half," said DeLaBruere.
With seven minutes left, the chances continued.
Quirion had another direct, this one from just on top of the circle, but Smith again went up and got the shot, leaving Marc to wonder what he had to do to get one past the West Rutland goal keeper.
"Everyone was hustling and we got off some nice shots. We could have scored, but I guess it just wasn't meant to be," said Quirion
There were less than two minutes remaining when Ji had the last go of it at the visitor's net.
He juked his way in, fired the ball, but Smith was on the ground to make the save.
The ball came loose for a second and there was hope, but the netminder recovered and grabbed the ball.
That would be it for UCA, as West Rutland now moves on to the second round.
"It was a terrific effort by both teams," said West Rutland coach Rick Hart. "Both groups were very evenly matched, but luckily we were able to get that one in on the breakaway."
This was one of the best games of the year for UCA.
They did all of the little things, and the big things too, to win a soccer a game, but the bounces just went the other way.
Maybe like Quirion said, it just wasn't meant to be.
In no way should the boys hang their head about the way this season ended.
If anything, their heads should be high in the air after going from a winless campaign in 2011 to hosting a first round play-off game in 2012.
Said DeLaBruere on the year as a whole, "I am so proud of these guys. We set some high expectations this year and we met every single one of them."
The team finished the season with a 6-6-3 record, including the play-offs.


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The College of Eastern Utah Lady Eagles volleyball team lost to the Salt Lake Community College Bruins on Sept. 24 at home.
The Lady Bruins beat CEU in three straight games, 30-13, 30-12 and 30-19.
CEU continues to hover near the bottom of the Scenic West Athletic Conference rankings with a 4-11 record.
Salt Lake remains the sixth best team in the nation, according to the National Junior College Athletic Association polls, with a 23-5 season record. The Lady Bruins are currently 3-0 in SWAC play.
The Lady Eagles will travel to Snow College on Oct. 1 to face the Lady Badgers. Snow College is also struggling this season with a 7-9 record and no SWAC wins. The team will follow with an Oct. 2 match against Dixie College.


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Video: One Million Motorists Skipped Out On $35M In Unpaid Thruway
By Joseph Spector
Albany Bureau Chief
ALBANY -- As the state Thruway Authority considers a whopping 45 percent toll increase on trucks, more than 1 million drivers between 2007 and 2011 avoided paying tolls and dodged $35 million in charges and fines.
Records reviewed by Gannett's Albany Bureau through a Freedom of Information request show that the beleaguered Thruway Authority's finances have been hurt by its inability to recoup tolls and fines from people who zip through EZ-Pass lanes scot-free.
Of the $35 million in uncollected tolls and fines since 2007, $7 million has been recouped through a credit agency, the Thruway said.
The biggest trouble spot is the Tappan Zee Bridge, records show. Between 2007 and 2011, nearly 80,000 passenger vehicles and trucks didn't pay the $5 roundtrip toll when they crossed the Hudson Valley bridge between Westchester and Rockland County. That accounted for $7 million in uncollected fines and tolls.
The state is planning to build a new Tappan Zee Bridge, with tolls that could be as high as $14 roundtrip.
WEB EXTRA: Send the Thruway Authority your thoughts via e-mail.
You can also contact the Thruway Authority by phone:
- Buffalo Division Headquarters: (716) 631-9017
- Thruway Authority Headquarters: (518) 436-2700
Business groups and state lawmakers have been critical of the Thruway's proposed 45 percent toll increase on most trucks. They said the uncollected tolls are one reason why any toll increase should receive further review. The Thruway delayed a vote in September.
"That's why I said let's have a forensic audit of their books," said Assembly Minority Leader Brian Kolb, R-Canandaigua. "We need a complete analysis before we implement a 45 percent toll increase."
The Thruway Authority has faced warnings from credit agencies that it needs to improve its finances and toll collections to maintain its credit rating. The agencies also said the 570-mile Thruway needs to increase tolls to ensure its fiscal stability.
The Thruway Authority defended its collections process, saying only a fraction of tolls are not collected. The Thruway is the longest toll road in the country.
"Toll violators cheat all other motorists traveling on the New York State Thruway," said agency spokesman Daniel Weiller. "While we do collect 99.6 percent of all tolls, any lost dollars are important because the Thruway receives no state financial support and therefore is dependent upon toll revenues to maintain the safety and reliability of the 574-mile superhighway."
Comptroller Thomas DiNapoli has criticized the Thruway Authority for its uncollected tolls.
In an August report, DiNapoli said the Thruway Authority last year collected $634 million in tolls -- representing 95 percent of its total revenue. As of last March, the Thruway Authority had submitted $18 million to a collections agency for uncollected tolls over the past two years.
In audits in recent years, the Comptroller's Office said it made 12 recommendations to improve toll collections, such as improving its billing system and developing a better way to collect tolls on rental cars.
DiNapoli's office said three of his recommendations were implemented, four were partially done, and five were not.
DiNapoli said improved toll collection should be among the steps the Thruway takes before it seeks a toll increase. The toll increase would bring in about $85 million a year in new revenue, the Thruway estimated.
"I think what people want to see is that they've tried everything," DiNapoli said in an interview Wednesday with Gannett's Albany Bureau. "Instead, they seem to go to the toll increase and then dismiss some of these other ideas. And that's always the easy way out."
Collecting tolls and fines can be difficult, records show.
For example, the top scofflaw in New York was Action Redi-Mix, a bankrupt concrete plant in Yonkers that went out of business two years ago. It owes the state $228,351 in tolls and fines as of March, the most recent statistics available.
Penske Trucking Leasing, based in East Chicago, was second at $152,429 in tolls and fines that were owed.
Some individuals who ranked tops on the state's unpaid toll list either couldn't be reached for comment or were unaware that they owed money to the state.
Asked about the wisdom of considering a toll increase for large trucks when it can't effectively collect all the tolls in the first place, NYS Thruway Authority Board Vice Chair Donna Luh told WGRZ-TV, "people certainly have the right to ask that question," beofre vowing to look into the mater further.
Luh says she was surprised to hear about the scope of uncollected tolls.
"It did catch myself and some of the other board members by surprise...we should have been more in the loop about this...I'm not going to try and spin that any other way," Luh said.
Mike Durant, state director for the National Federation for Independent Business, said the Thruway Authority needs to find more efficiencies and better toll collections before it hits up drivers with higher tolls. Tolls were increased 5 percent in 2009 and 2010 for all drivers, and EZ-Pass discounts were reduced.
"They need to fix it themselves -- not the on back of business owners, tollpayers and taxpayers," Durant said. He said government becomes "addicted to going to business owners and taxpayers to solve their problems, they can't help themselves."
The Thruway began using EZ-Pass in 1993, allowing for tags in front car windows to track toll usage and to bill a travel's account. But it also removed barriers at many toll plazas, making it easier to zoom through without paying.
And as tolls have increased in recent years, so too has the amount that's not been collected. The number of toll violators increased from 157,743 in 2007 to 224,474 in 2011, up 42 percent.
Each violation come with a $25 fine, and most of the uncollected money comes from fines -- totaling about $20 million over the past five years, the Thruway Authority said.
Since the system was established, it has been extended to more than a dozen states, with most users using credit cars to pay their bills.
For users without EZ-Pass who don't pay the tolls, the state uses a photograph of the license plate to identify the vehicle's owner. Then they are billed the full toll from Buffalo to Woodbury, which is in the Hudson Valley.
Some drivers have balked at the full cost, and some lawmakers have sought to change the law so drivers aren't penalized for the full length of the Thruway.
The Thruway Authority is also hurt by not having jurisdiction to take additional steps against out-of-state violators. While in-state EZ-Pass users can have their accounts suspended, New York can't do the same for out-of-state violators, state officials said.
"Uncollected tolls from violators are costly to recover, and the authority has no out-of-state enforcement ability," Weiller said. "We are working with the Metropolitan Transportation Authority and the Port Authority of New York and New Jersey to pursue stronger enforcement legislation."
As states seek additional revenue, some are starting to work together. Maine, Massachusetts and New Hampshire this year allowed each other to suspend the vehicle registrations of violators in their states.
The Thruway estimates that about 30 percent of its uncollected tolls and fines come from out-of-state users.
The uncollected tolls come as Thruway expenses have outpaced revenue. Toll-paying riders dropped about 10 percent from 2005 to 2011.
In an audit in August, DiNapoli found that costs at the Thruway Authority rose 36 percent over the past decade and debt payments nearly doubled. Revenue hasn't kept up, largely because of declining traffic.
DiNapoli said that from 2002 through 2011, revenue grew 4 percent annually and expenses grew 5 percent.
"Too often in the past the Thruway has pushed costs and difficult decisions to the future by raising tolls or borrowing," he said in the August statement.
Includes reporting by the Journal News database analyst Tim Henderson and Gannett Albany Bureau staff writer Haley Viccaro.
-- More than 1 million drivers since 2007 avoided paying tolls on the state Thruway and dodged $35 million in charges and fines.
-- The Thruway Authority said it has recouped about $7 million through a collection agency.
-- As tolls rose, so did scofflaws. The number of toll violators increased 42 percent between 2007 and 2011.
-- Out-of-state violators account for about 30 percent of the uncollected tolls, and they face limited punishment.
Coming Next Sunday:
As the state Thruway Authority weighs a steep toll hike on most commercial trucks, there have been renewed discussions about whether the state's canal system should remain on its books or be overhauled.


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"Mount Rushmore" greeting card by Frank Romeo. Ships within 2 - 3 business days and includes a plain white envelop for mailing and/or gift giving. Available in vertical and horizontal orientations.
The photography of Frank Romeo, featuring Fine Art prints of the American West, Route 66, and Cities of the United States. My work has been seen and published worldwide, most recently in the documentary motion picture "Autumn of Route 66" and cover art for the latest CD released by the band Turkuaz. A heartfelt thanks goes out to the folks who now display my art in their homes and offices. I would love to hear from you, so drop me a line through the site itself, or at my Facebook Photography Page: FrankFooterFotos You are also invited on a cross country road trip along old Route 66: Travel Route 66 - FrankFooterFotos My Story: I was a 40-something accountant who was downsized (fired) one too many times. After the last company...
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EUR-USD has been well bid today, piercing above 1.1360 and showing a 0.7% gain since the London open. Gains above 1.13 had proved to be fleeting over both the last day and on several other occasions since Sept-20, but the lack of dips and building momentum suggests this is a move of greater conviction this time around. The Sept-18 high at 1.1460 provides the next upside focal point, while support is now marked by former daily highs at ... Read More ►
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North American Edition2015-10-09 11:02 UTC
The dollar and yen dove against the euro, commodity currencies and a variety of emerging world currencies as a risk-on sentiment coursed through global markets. The pound was also among the underperformers following an unexpected 4.3% m/m contraction in UK construction output in August. EUR-USD rose 0.7% in piercing 1.1360 for the first time since Sept-18. The run was sparked by above-forecast French production numbers, data not normally a euro mover ... Read More ►
European Edition2015-10-09 06:35 UTC
Commodity currencies have rallied, along with various Asian and other emerging world currencies at the expense of the dollar, yen, euro and other majors. This theme has been fuelled by a risk-on environment after the FOMC minutes from the mid-September meeting effected a further lengthening of odds for a Fed rate hike by year end. The minutes showed that "several members" were worried that downside risk to growth and inflation have increased due to ... Read More ►
Asian Edition2015-10-08 18:46 UTC
FX trade was relatively quiet in N.Y. on Thursday morning, as the dollar put in another mixed performance, though ended the day slightly underwater overall. A slightly smaller than expected jobless claims outcome helped the dollar marginally early on, though position squaring became evident into the FOMC minutes release. The minutes didn't provide any clear insight into rate hike timing. For most every hawkish indication, there was an offsetting ... Read More ►
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Dedicated to students' academic success, the Academic Advising office staff will work with you on nearly any academic concern. You can come to the office for instruction on study skills and time management, to receive peer tutoring, to arrange for disability accommodations, to apply for a leave of absence, and to get support for managing your academic obligations while dealing with a personal or medical concern. To arrange an appointment, drop by the office or call 269-3702.
Plan on attending this free workshop!
Wednesday, September 16
noon - 1 p.m., Rosenfield Center, Room 209


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SAN FRANCISCO, October 24, 2009 – At the American Academy of Ophthalmology's (AAO) Annual Meeting, Canon U.S.A., Inc., a leader in medical imaging, will shine the spotlight on the latest addition to its complete line of total digital imaging and workflow management solutions for eyecare professionals, the CX-1 Mydriatic/Non-Mydriatic Hybrid Digital Retinal Camera1, in the North Hall, booth #3048 at the Moscone Center in San Francisco (October 24th - 27th).
The CX-1 is the Company's first fully hybrid digital retinal camera with both mydriatic and non-mydriatic modes. With one-touch, the operator can automatically switch between mydriatic and non-mydriatic modes, effortlessly utilizing different functions within seconds and performing several concurrent ocular tests.
"Canon continues to provide ophthalmologists with the latest digital imaging technology, allowing eyecare professionals to continue to provide comprehensive, high-end care to their patients," said Tsuneo Imai, senior director and general manager, Medical Systems Division, Canon U.S.A." At AAO, ophthalmologists will witness how the CX-1 Mydriatic/Non-Mydriatic Hybrid Digital Retinal Camera can play a significant role in helping them to efficiently operate their practices."
The Canon CX-1 allows the user to take one-shot FAF (Fundus Autofluorescence) photography, in a standard configuration, for both mydriatic and non-mydriatic modes. Detecting Autofluorescence of the retina is an important indication of the retina's health. Using the non-mydriatic mode not only saves time and resources, it also can make the diagnostic procedure more comfortable for the patient.
Canon's EOS camera technology, with its renowned image processing capabilities, has been adapted exclusively for medical use in the CX-1, providing up to 15.1-megapixel resolution. The CX-1 is capable of delivering clear and detailed diagnostic images for virtually immediate review. The single onboard digital camera handles five different photography modes with ease, including FAF, Color, Red-Free, Cobalt and Fluorescein Angiography photography.
The Retinal Imaging Control Software that comes with the CX-1 puts tools for image capture controls and easy viewing at a users fingertips. The intuitive graphical interface is simple and straightforward to use. The DICOM-compliant network interface allows easy integration with existing medical imaging systems and connection to PACS and HIS network configurations.
Also on display, Canon will demonstrate the synergy between the Company's retinal camera systems and Optical Coherence Tomography (OCT) products from OPTOPOL Technology S.A. OPTOPOL Technology S.A. SPOCT High Resolution2 (HR) provides ultra-high resolution which can help give the doctor more comfort in diagnosis. Optical Coherence Tomography ultra-high scanning speeds shorten data collecting times and help to improve comfort of examination for patient and operator. The SPOCTHR has three micron axial resolution which, when combined with advanced analysis algorithm, makes SPOCTHR state-of-the art in SPOCT technology. Also showcased will be the OPTOPOL Technology S.A. SPOCT, which allows for non-invasive cross sectional imaging of the retina, while providing true, fast, 3D-imaging. The automated perimeter PTS 10003 from OPTOPOL Technology S.A will also be featured. The PTS 1000 is a diagnostic instrument that offers precise and fast testing of the field of vision. It features a wide range of strategies and analysis tools combined with intuitive interface, providing retinal specialists with a powerful diagnostic tool.
Canon offers and markets a full line of digital imaging solutions for the ophthalmic world, including Non-Mydriatic and Mydriatic Digital Retinal Cameras, Full Auto-Tonometer and Full Auto-Ref Keratometers, and image management software, all of which will be on display at the show. The Canon product line includes:
For more information about Canon ophthalmic devices and solutions, please go to www.usa.canon.com/eye-care.
Canon U.S.A., Inc. is a leading provider of consumer, business-to-business, and industrial digital imaging solutions. Its parent company, Canon Inc. (NYSE:CAJ), a top patent holder of technology, ranked third overall in the U.S. in 2008†, with global revenues of US $45 billion, is listed as number four in the computer industry on Fortune Magazine's World's Most Admired Companies 2009 list, and is on the 2009 BusinessWeek list of "100 Best Global Brands." Canon U.S.A. is committed to the highest levels of customer satisfaction and loyalty, providing 100 percent U.S.-based consumer service and support for all of the products it distributes. At Canon, we care because caring is essential to living together in harmony. Founded upon a corporate philosophy of Kyosei – "all people, regardless of race, religion or culture, harmoniously living and working together into the future" – Canon U.S.A. supports a number of social, youth, educational and other programs, including environmental and recycling initiatives. Additional information about these programs can be found at www.usa.canon.com/kyosei. To keep apprised of the latest news from Canon U.S.A., sign up for the Company's RSS news feed by visiting www.usa.canon.com/rss.
† Based on weekly patent counts issued by the United States Patent and Trademark Office
All referenced product names, and other marks, are trademarks of their respective owners.
Specifications subject to change without notice.
1 The CX -1 Mydriatic/Non-Mydriatic Hybrid Digital Retinal Camera is not currently for sales or lease in the United States. Pending 510(k) clearance by the FDA.
2 OPTOPOL Technology S.A. SPOCT-HR is not currently for sales or lease in the United States. Pending 510(k) clearance by the FDA.
3 OPTOPOL Technology S.A. PTS 1000 is currently not for sale or lease in the United States.


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Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites (TONIC)
Recruitment status was Not yet recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of the study is to investigate the efficacy and safety for the management of hyponatremia and ascites in patients with liver cirrhosis.
Drug: Tolvaptan
Drug: placebo
Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
|Official Title:
|Efficacy and Safety Study of Tolvaptan for Liver Cirrhotic Patients With Hyponatremia and Ascites: A Multi-center, Randomized, Double-blind, Placebo-controlled 4-weeks Clinical Trial
- the change in the average daily area under the curve (AUC) for the serum sodium concentration from baseline to day 28 after intervention [ Time Frame: baseline and 28 days ] [ Designated as safety issue: No ]
- the change in the average daily area under the curve (AUC) for the serum sodium concentration from baseline to day 4 [ Time Frame: baseline and 4 days ] [ Designated as safety issue: No ]
- the time to normalization of the serum sodium concentration [ Time Frame: up to 28 days ] [ Designated as safety issue: No ]
- the time to first paracentesis, number of paracentesis, the volume of ascitic fluid obtained from paracentesis [ Time Frame: up to 28 days ] [ Designated as safety issue: No ]
- Abdominal discomfort based on a 100-mm visual analogue scales (VAS) [ Time Frame: day 1, 2, 3, 4, 7, 14, 21, 28 ] [ Designated as safety issue: No ]
- The change in the dose of concomitant diuretics from baseline at day 28 [ Time Frame: day 1, 2, 3, 4, 7, 14, 21, 28 ] [ Designated as safety issue: No ]
- the number of participants with serious adverse events [ Time Frame: from baseline to day 28 after intervention ] [ Designated as safety issue: Yes ]
- the time to ascites improvement [ Time Frame: up to 28 days ] [ Designated as safety issue: No ]
- the time of worsening of ascites [ Time Frame: up to 28 days ] [ Designated as safety issue: No ]
|Estimated Enrollment:
|Study Start Date:
|November 2012
|Estimated Study Completion Date:
|February 2014
|Estimated Primary Completion Date:
|January 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: Tolvaptan group
Form : Tablet, Dosage: 15 mg, 30 mg or 60 mg, Frequency: once a day. Duration: 28days
Drug: Tolvaptan
15 - 60 mg/day for 28 days
Other Name: SAMSCA
Placebo Comparator: Placebo group
Form : Tablet, Dosage: 15 mg, 30 mg or 60 mg, Frequency: once a day. Duration: 28days
|Drug: placebo
Detailed Description:
Patients with advanced cirrhosis frequently develop dilutional hyponatremia due to impairment of their renal ability to eliminate solute-free water. Although the pathophysiology of this disorder is multifactorial, an increased hypersecretion of arginine vasopressin (AVP) is a major factor. The prevalence of hyponatremia in cirrhosis, as defined by a serum sodium level of 130 mmol/L is reported to be about 20%, and there are several lines of evidence that hyponatremia is a risk factor for the development of hepatic encephalopathy, and that it predicts a poor quality of life independent of liver function. Hyponatremia also predicts short-term mortality in cirrhotic patients awaiting liver transplantation. The principle of the management of hypervolemic hypona- tremia is to induce a negative water balance, with the aim of normalizing the increased total body water, which would result in an improvement in serum sodium concentration. Fluid restriction is the most widely accepted nonpharmacological therapy, but its efficacy is very limited. The administration of hypertonic sodium chloride has been common in severe hypervolemic hyponatremia, but its effect is only partial and short lived; moreover, additional expansion of fluid can worsen ascites and edema. Therefore, the pathophysiologically oriented treatment of hyponatremia focuses on inhibiting the actions of AVP. Recently, antagonists of the V2 receptors of vasopressin has been proposed to manage hyponatremic patients, such as heart fauilure, syndrome of inappropriate antidiuretic hormone or liver cirrhosis. Especially, a lot of hyponatremic patients with cirrhosis had ascites, and some of them had intractable ascites. In these patients, antagonists of the V2 receptors of vasopressin including tolvaptan might have beneficial effect in enhancing not only hyponatremia , but also ascites
|Ages Eligible for Study:
|20 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- 20 years of age or older
- Patients with cirrhosis as diagnosed by liver biopsy or a combination of laboratory (thrombocytopenia), radiologic (cirrhotic feature of liver, splenomegaly, collateral shunt on US, CT, or MRI) and endoscopic findings (gastoesophageal varices or portal hypertensive gastropathy)
- ≥ Grade 2 ascites who have already been treated with restricted salt diet within 3 month
- Hyponatremia (Serum sodium ≥120 mEq/L and ≤130 mEq/L)
- Written informed consent
Exclusion Criteria:
- Hypovolemic hyponatremia (Patients with hypotension or chronic heart failure)
- Serum potassium concentration > 5.5 mEq/L
- Serum bilirubin > 5.0 mg/dL
- Blood coagulation factor < 40% or international normalized ratio (INR) > 2.3
- Platelet count < 30,000/mm3
- Serum creatinine > 3 mg/dL
- Treatment within 2 weeks with vasopressin anlogues
- Systolic blood pressure <80 mmHg
- History of gastrointestinalesophageal varix bleeding variceal hemorrhage
- Spontaneous bacterial peritonitis
- Hepatic encephalopathy ≥ grade 3
- History of Hepatocellular carcinoma treatment within 3month or viable tumor Viable hepatocellular carcinoma
- Liver transplant
- Previous treatment with transjugular intrahepatic portosystemic stent shunt (TIPS)
- History of significant cardiac diseases such as recent myocardial infarction or ischemic diseases within 1 year of screening
- Prolonged QTc interval of > 500 ms based on electrocardiography
- Treatment within 2 weeks with substances or drugs that may either induce or significantly inhibit cytochrome P450 3A (ketoconazole, clarithromycin, erythromycin, fluconazole, diltiazem, verapamil, etc)
- Pregnant or breast feeding
- Patients with galactose intolerance or malabsorption (as production of the drug contains lactose)
- HbA1Cc ≥ 9 %
- Serious medical illness (e.g. heart failure, severe pulmonary disorders, alcohol dependence, malignant tumors, etc)
Please refer to this study by its ClinicalTrials.gov identifier: NCT01716611
|Contact: Won Hyeok Choe, MD
|Korea, Republic of
|Konkuk University Medical Center
|Not yet recruiting
|Seoul, Korea, Republic of, 143-729
|Contact: Won Hyeok Choe, MD 82-2-2030-5027 firstname.lastname@example.com
|Principal Investigator:
|June Sung Lee, MD, PhD
|Inje University
No publications provided
|Responsible Party:
|Won Hyeok Choe, Associate Professor, Konkuk University Medical Center
|ClinicalTrials.gov Identifier:
|NCT01716611 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 18, 2012
|Last Updated:
|October 29, 2012
|Health Authority:
|Korea: Institutional Review Board
Keywords provided by Konkuk University Medical Center:
liver cirrhosis
antidiuretic hormon
arginine vasopressin
Additional relevant MeSH terms:
Metabolic Diseases
Pathologic Processes
Water-Electrolyte Imbalance
ClinicalTrials.gov processed this record on October 09, 2015


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