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Memb-PASS Membrane Protein CrystallographyUse less protein and accelerate the process of crystallizing membrane proteins using the new patent-pending Memb-PASS (Prompt Assay of Size and Stability) technology, developed by Dr. Michael Wiener and members of his laboratory at the University of Virginia.
|Memb-PASS starts with a Differential Filtration Detergent Assay, a microplate-based detergent screening method that rapidly characterizes the stability and size of membrane proteins exchanged into a ninety-four detergent panel provided with the Memb-PASS Differential Filtration Detergent Assay. The entire assay utilizes sub-milligram quantities of membrane protein, and requires only several hours to perform while quickly helping you select the best detergent complex for your membrane protein! [1]
After the protein is in a suitable detergent, as determined by the Memb-PASS Differential Filtration Assay, the Memb-PASS Solubility Screen, with twenty-four conditions, is applied to determine the proper protein concentration for crystallization.
Once at proper concentration, the membrane protein can then be set up for crystallization with the Memb-PASS Crystallization Screen, an innovative, ninety-six condition screen, developed for integral membrane protein crystallization based on conditions that resulted in successful crystallization of membrane proteins.
Available Products
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Flyer Memb-PASSTM (PDF, 1.1 MB)
References[1] Vergis et al. (2010) A high-throughput differential filtration assay to screen and select detergents for membrane proteins. Anal. Biochem. 407:1.
[2] Vergis et al. (2011) The variable detergent sensitivity of proteases that are utilized for recombinant protein affinity tag removal. Prot. Expr. Purif. 78:139.


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Rick Moody
News about Rick Moody, including commentary and archival articles published in The New York Times.
Rhapsody, a Lofty Literary Journal, Perused at 39,000 Feet
For its front-cabin passengers, United Airlines is turning Rhapsody into the Paris Review of the air, attracting authors like Joyce Carol Oates and Anthony Doerr.
May 4, 2015, Monday
MORE ON RICK MOODY AND: Magazines , Rhapsody (Magazine) , United Airlines , Writing and Writers , Airlines and Airplanes , Book Trade and Publishing , Moody, Rick , Oates, Joyce Carol
Rick Moody's essays wrestle with performers and songs as if they were his better angels and personal hellhounds.
June 3, 2012, Sunday
MORE ON RICK MOODY AND: Moody, Rick , Books and Literature , Music
Frieze Art Fair New York Announces Commissioned Art Projects
The American version of London's annual Frieze Art Fair, which makes its debut in New York in May, it has commissioned eight artists to construct what is calls "a temporary pop-up village'' on Randall's Island, where the fair will take place.
January 25, 2012, Wednesday
MORE ON RICK MOODY AND: Rollins, Tim , Moody, Rick , Ahearn, John , Art , News , Frieze Art Fair , Randalls Island (NYC)
Letting a Flying Hairy Arm Take It Away
A novel within a novel features a sci-fi hack writing about a disembodied killer arm.
August 17, 2010, Tuesday
Going Digital
Rick Moody's comic novel is built around a 2025 remake of a B-movie horror flick.
August 8, 2010, Sunday
MORE ON RICK MOODY AND: Books and Literature , Moody, Rick , Movies
Up Front: Rick Moody
For Rick Moody, the only downside to reviewing a Led Zeppelin biography was the inevitable flashback to 1970s power ballads.
December 27, 2009, Sunday
The Best Mind of His Generation
Obsessive, ironical, needy: David Foster Wallace's voice was the voice in your head.
September 21, 2008, Sunday
MORE ON RICK MOODY AND: Books and Literature , Moody, Rick , Eggers, Dave , Wallace, David Foster , Suicides and Suicide Attempts , Writing and Writers , Tennis , Eugenides, Jeffrey , Franzen, Jonathan , Lethem, Jonathan , Chabon, Michael , Powers, Richard
When People, Culture and Even Time Are Suspect
None of these three novellas seems to reflect much of anything happening to Rick Moody, apart from the challenge to write dexterously.
July 2, 2007, Monday
In the longest of these three novellas, Rick Moody envisions Manhattan after a nuclear blast.
June 3, 2007, Sunday
In Rick Moody's showbiz satire, a producer wants to make a mini-series about humanity's historic quest for water.
October 2, 2005, Sunday
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subset: commoncrawl


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R&D spend*: $3.5B (12th),
down 5.4%; 20% of rev.
Top brands: Actos ($3.4B); Velcade ($693M), Dexilant ($555M); ActoPlusMet ($472); Amitiza ($264M)
Planned launches:
Alogliptin (diab.), TAK-700 (onc.), Contrave (obesity), peginesatide (anemia)
Promotional spend:
$668M (11th); 10.1% of rev.
Patent expirations:
Actos (2012)
Takeda is in the teeth of a steep patent cliff, with Prevacid bleeding share and Actos, which accounts for half of US sales, set to lose exclusivity in August. The Japanese firm hopes to overcome these headwinds via its "Transformation into a New Takeda" plan, which includes a new R&D hub in Shonan, streamlining the US sales force (by 1,400 US jobs in 2010 and another 700, announced in January) and acquisitions like last year's $13.7-billion deal for European pharma Nycomed and this year's $800-million deal for URL Pharma, while reaching beyond its heritage in metabolic, oncology (Millennium) and CNS to immunology and inflammation. And the company hopes to grow US sales of Prevacid follow-on Dexilant, Daliresp for COPD, Uloric for gout, cancer drug Velcade and antihypertensive Edarbi. Two late-stage candidates, obesity drug Contrave and DPP-4 inhibitor alogliptin, have run into FDA roadblocks.
* Global revenue and R&D spend are based on the financial year ending March 31, 2011, the latest data available at press time.
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Specialty medicines continue to be a hot category, one in which spending has surged behind products that treat medicine's most complex diseases. This eBook lays out the needs and hurdles along the specialty drug pathway, explaining how stakeholders are working to get meds into patients' hands and ease their experience. Click here to download.


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Black Diamond
Positron Quickdraw (Mocha W/ Mocha Dynex)
In Stock Product Number: 25684
With two Positron carabiners and a lightweight 14 mm Dynex™ dogbone, the Black Diamond Positron Quickdraw is our top value in full keylock functionality. The light, smooth-clipping design eliminates snags whether you're cranking on sport routes or extending gear placements, and the integrated Straitjacket insert keeps the bottom biner in the optimal clipping position.
* This product does not qualify for shipping to all countries.
- Straight-gate Positron on top, bentgate Positron on bottom
- Dual keylock noses ease clipping and cleaning
- 14 mm Dynex dogbone is light, durable, and easy to grab
- Straitjacket insert keeps bottom carabiner properly oriented
- For safety and/or sanitary reasons, this product CANNOT be returned
Gender: Unisex
Weight: 107 g, 3.8 oz –12 cm; 110 g, 3.9 oz
Season: F14 S15
Vendor ProductId: 381044
Review ProductId: 25684
Reviewed by 2 customers
Sort by
Comments about Black Diamond Positron Quickdraw (Mocha W/ Mocha Dynex):
Work great strong and well made. A little discoloration where the carabeaner was on the bolt. Over all great I would buy them again.
Comments about Black Diamond Positron Quickdraw (Mocha W/ Mocha Dynex):
I'm not chincy, but I don't mind a good deal--thus the Positron is my favored QD. Great draws: full keylock convenience, snappy performance, and with a beefy feel that doesn't seem heavy, but inspires confidence. Maybe not the best for your alpine rack, otherwise these draws are a win/win. And the mocha color is sexy...at least hanging on me.


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Vining continues his solid pitching
It has been a process and a project this spring for a mostly inexperienced Kettle Falls baseball team long on youth and generally short of pitching.
The Bulldogs (5-5, 6-7) picked up a Northeast 2B (Bi-County League) doubleheader win over Springdale last Tuesday and split a non-league doubleheader with host Priest River of the Idaho Panhandle's Intermountain League on Thursday.
Kettle Falls was at Reardan (0-8, 3-9) on Tuesday for a key NE 2B doubleheader. The Bulldogs of coach Landon Johnston will travel to Spokane on Saturday to face St. George's (1-7, 1-11) in a twinbill. The first game gets underway at noon.
Kettle Falls will end the regular season next Tuesday with a doubleheader at home against Davenport. The first game will get underway at 3 p.m.
"This is an important stretch for us," Johnston said on Monday. "We need to make up some ground (on league-leading Lind-Ritzville/Sprague, NWC and Colfax)."
With games against two of the weakest teams in the NE 2B, that should be a realistic goal.
Certainly, the Bulldogs, winners of four of their last five games, are getting quality starts from staff ace Tyler Vining. KFHS tends to play well behind Vining, although run support of the big junior right-hander has been sketchy at times.
Sharp in opener against Springdale
But in Vining's latest start, a complete game 10-0 whitewash of Springdale (3-7, 3-7) on April 17, he got plenty of offensive support, although the Bulldogs nursed a 1-0 lead behind Vining until KFHS plated five runs in the bottom of the fifth inning and four more in the sixth to break the game open.
Vining (2-2) went the six-inning distance, scattering three hits, fanning 10 and issuing no walks. He struck out the side twice during the game and was in total command.
"Tyler just pitched lights out," Johnston said of Vining, who is getting stronger with each outing.
Kettle Falls got all the runs they would need in the first inning when leadoff Devin Thompson walked and came around to score on a pair of infield outs.
In the Kettle Falls fifth inning, Brandon Thomas laced a two-run double. Hot-hitting shortstop Nathan Disque continued his torrid pace, lacing an RBI single. Vining also had an RBI single in the inning.
Thomas, Disque (four RBIs) and Vining all doubled in the four-run sixth inning.
Kettle Falls committed only one error behind Vining.
Kettle Falls also stole five bases.
Cook sharp in relief
In the second game, KFHS started slowly, but picked up the pace with five runs in the third inning, four in the fourth and five more in the fifth inning. The Bulldogs collected 10 hits and took advantage of five Springdale errors.
Thomas went three innings and got the second game win for KFHS. He surrendered four runs (two earned), scattered five hits, struck out two and walked three.
Catcher Logan Cook, who came on in relief of Thomas in the fourth inning, rolled his ankle during the doubleheader, but stayed in the game. He was effective on the mound and threw out two base runners from behind the dish.
Cook struck out four in his two innings of work. He didn't allow a run, a hit or a walk.
For Kettle Falls, seven of nine starters hit safely in the nine-hit attack.
Disque was 2 for 3 and had three RBIs. He had seven on the day.
Cook and Thomas both had a pair of RBIs (doubles).
Freshman Stacy Schauls was 2 for 3 with three runs scored.
Kettle Falls dropped a 7-6 decision to Priest River in the opener of last Thursday's doubleheader in north Idaho.
Brent McNeill got a rare start and threw 3.2 innings for the Bulldogs. He surrendered seven runs (six earned) and gave up five hits. He struck out six and issued eight walks.
Jeff Thomas came on in relief and worked 2 1/3 innings (one hit, no runs, one strikeout and three walks).
Walks kill
"Clearly, those 11 walks were the difference in the first game," Johnston said.
One of the highlights of the opener was the first hit of the season by little-used foreign exchange student "Kei" Ching. His RBI single came in the fourth inning.
KFHS, trailing 7-3 heading into the top of the seventh, rallied for three runs and had the tying run in scoring position (third base) when the game ended.
Disque and freshman Brady Hansen had RBI singles in the inning.
Disque was 3 for 3 with three runs scored and an RBI. VIning was 2 for 2 with an RBI and a run scored.
In the second game, Reuben Winter went the distance to register his first win for KFHS. The senior went 5 1/3 (called because of darkness) and gave up three runs in the 5-3 win.
He scattered four hits and struck out eight. He issued three walks.
Kettle Falls collected four hits, but drew 10 walks. The Bulldogs committed only one error behind Winter.
McNeil stole a pair of bases. He has 11 steals in as many attempts.
[1] http://www.statesmanexaminer.com/sites/default/files/Baseball.grrrr_.jpg
[2] mailto:email@example.com


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Book your room at Paradisus Playa del Carmen La Perla- All Adult/All Inclusive
Get an overview of this hotelAdult Only 5* All Inclusive Resort steps away from Playa del Carmen's 5th Av.
+VIP Access™ Hotel
We carefully hand-picked this hotel based on its dedication to service and excellent guest reviews.
Expedia +gold members receive free room upgrades and +gold and +silver members get other perks upon availability at check-in.See details
Adults Only Vacation
Paradisus Playa del Carmen La Perla provides unique and memorable Luxurious Adult Only vacation, in a pristine white sand Caribbean beach just steps away from the attractions of Playa del Carmen's 5th Avenue
Beyond All Inclusive
LUXEclusive reinterprets All Inclusive into a world-class facilities Resort, with the ultimate in Spa treatments, all around the world cusine experience, Premium brand drinks, and life-enriching experiences
Suites for your senses
The Resort offers exclusive elegant warm Suites, with sensory tub, 24 hours room service, Cable TV & CD/DVD. Relax at the private tanning area of the terrace of the swim-up suites with direct access to the poolInformation missing or incorrect? Tell us!
Hotel Amenities
All-Inclusive Details
This resort is all-inclusive. Onsite food and beverages are included in the room price (some restrictions may apply).
Gratuities and taxes
Gratuities and taxes are included.
Food and beverages
- All buffet and à la carte meals, snacks, and beverages included
- 24-hour room service (limited menu)
Activities and facilities/equipment
Land activities
- Bicycling
- Climbing wall
- Fitness facilities
- Miniature golf
- Bartending
- Dancing
- Pilates
- Water fitness
Not included
- Golf green fees
- Use of golf cart
- Use of golf equipment
- Motorized water sports
- Childcare
Hotel Amenities
Paradisus Playa del Carmen La Perla - All Inclusive features a full-service spa, a marina, and 2 outdoor swimming pools. Guests can dine at one of Paradisus Playa del Carmen La Perla - All Inclusive's 12 restaurants and pick up coffee at one of the 8 coffee shops/cafés. The hotel also has a snack bar/deli. Guests can unwind with a drink at one of the hotel's bars, which include 2 swim-up bars and 8 bars/lounges. Guests can enjoy a complimentary breakfast each morning. An Internet point is located on site and high-speed wired and wireless Internet access is complimentary. Business amenities consist of a business center, a technology helpdesk, and secretarial services. Event facilities measuring 25.000 square feet include a conference center, a meeting/conference room, a ballroom, and exhibit space. This all-inclusive hotel also offers a health club, a spa tub, and a fitness facility. For a surcharge, the property provides a roundtrip airport shuttle (available on request), a theme park shuttle, and a shopping center shuttle. Onsite parking is complimentary. Paradisus Playa del Carmen La Perla - All Inclusive has designated areas for smoking.
- 24-hour fitness facilities
- 24-hour front desk
- Arcade/game room
- ATM/banking
- Beach towels
- Beach umbrellas
- Pool umbrellas
- Business center
- Computer station
- Conference center
- Designated smoking areas
- Dry cleaning/laundry service
- Elevator/lift
- Express check-in
- Express check-out
- Free breakfast
- Free valet parking
- Free WiFi
- Full-service spa
- Garden
- Gift shops or newsstand
- Hair salon
- Library
- Limo or Town Car service available
- Luggage storage
- Marina on site
- Multilingual staff
- Number of buildings/towers - 5
- Number of floors - 4
- Number of outdoor pools - 2
- Number of restaurants - 5
- On private beach
- One meeting room
- Outdoor tennis court
- Porter/bellhop
- Rooftop terrace
- RV, bus, truck parking
- Safe-deposit box at front desk
- Sauna
- Shopping center shuttle (surcharge)
- Shopping on site
- Snack bar/deli
- Spa treatment room(s)
- Spa tub
- Steam room
- Tennis on site
- Theme park shuttle (surcharge)
- Total number of rooms - 394
- Turkish bath/Hammam
- Wedding services
- Year Built 2011
Family Friendly Amenities
- Arcade/game room
- Free Wi-Fi
- Outdoor pools
- On private beach
- Outdoor tennis court
- Rollaway/extra beds available
- Snack bar/deli
- Soundproofed rooms
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free valet parking, RV, bus, truck parking
Room Amenities
- Air conditioning
- Balcony
- Bathrobes
- Blackout drapes/curtains
- Cable TV service
- Climate control
- Coffee/tea maker
- Connecting/adjoining rooms available
- Daily housekeeping
- Deep soaking bathtub
- Designer toiletries
- Desk
- Down comforter
- Egyptian-cotton sheets
- First-run movies
- Flat-panel TV
- Free WiFi
- Hair dryer
- Hypo-allergenic bedding available
- In-room safe (laptop compatible)
- iPod docking station
- Iron/ironing board
- Minibar
- Phone
- Pillow menu
- Premium bedding
- Private bathroom
- Rainfall showerhead
- Rollaway/extra beds available
- Room service (24 hours)
- Separate bathtub and shower
- Separate sitting area
- Sleep Number by Select Comfort mattress
- Slippers
- Soundproofed rooms
- Turndown service
Where to Eat
A complimentary hot and cold buffet breakfast is served each morning in the restaurant between 7 AM and 11 AM. BANA - Overlooking the garden, this sushi bar serves dinner only. Guests can order drinks at the bar and enjoy al fresco dining (weather permitting). Reservations are required. FUEGO - Overlooking the ocean and garden, this theme restaurant serves dinner only. Guests can order drinks at the bar and enjoy al fresco dining (weather permitting). Reservations are required. PASSION - This fine-dining restaurant serves dinner and has a bar. Reservations are required. HADAR - Overlooking the pool and garden, this buffet restaurant serves breakfast, lunch, and dinner. Reservations are required. THE GRILL - Overlooking the ocean and pool, this bistro serves lunch and dinner. 24-hour room service is available.
Nearby Things to Do
An outdoor tennis court, a marina, and a health club are featured at the hotel. Two outdoor swimming pools are on site along with a spa tub. Other recreational amenities include a sauna, a steam room, and a fitness facility. The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Surfing/boogie boarding nearby
- Water skiing nearby
- Scooter/moped rentals nearby
- Personal motorized watercraft on site
- Ecotours nearby
- Golf lessons available nearby
- Aerobics on site
- Motor boating on site
- Parasailing on site
- Pilates classes on site
- Playground on site
- Sailing on site
- Scuba diving on site
- Snorkeling on site
- Tennis lessons on site
- Volleyball on site
- Windsurfing on site
- Yoga classes/instruction on site
Spa Services
YHI Spa has 14 treatment rooms including massage/treatment rooms and couples treatment room(s). Services include massages, manicures and pedicures, body wraps, and body scrubs. A variety of treatment therapies are provided, including aromatherapy, hydrotherapy, and Ayurvedic treatments. The spa is equipped with a sauna, a spa tub, Turkish bath/hammam, hot springs/mineral springs, and a mud bath. Visitors of this garden view spa can round out their time of relaxation with a trip to the café. Guests under 18 years old are not allowed in the spa.
- Number of treatment rooms 14
- Couples treatment rooms
- Manicures and pedicures
- Body wraps
- Body scrubs
- Aromatherapy treatments
- Hydrotherapy treatments
- Ayurvedic treatments
- Mud bath in spa
- Sauna in spa
- Spa tub in spa
- Hot springs/mineral springs in spa
- Massages
- Minimum age to access spa is 18
- Body treatments
- Facial treatments
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible bathroom
- Accessible parking
- In-room accessibility
- Roll-in shower
Hotel Policies
Check-in time starts at 3 PM
Minimum check-in age is 18
Check-out time is noon
Payment types
Children and extra beds
- This property does not allow children.
- Rollaway/extra beds are available.
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
We should mention
Reservations are required for massage services and spa treatments. Reservations can be made by contacting the resort prior to arrival, using the contact information on the booking confirmation. Only registered guests are allowed in the guestrooms. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation. Some facilities may have restricted access. Guests can contact the property for details using the contact information on the booking confirmation.
Awards & Affiliations
- This property is affiliated with the International Gay & Lesbian Travel Association (IGLTA) and welcomes lesbian, gay, bisexual, and transgender (LGBT) guests.
Up to $1500 USD Resort Credit Offer
Up to $1500 USD Resort Credit Offer
Book a 4-night minimum stay in any Up to US$1,500 Resort Credit! rate plan now - December 22, 2015 for travel May 1 - December 22, 2015 and receive the following:
- $550 USD in resort credit for stays of 4-6 nights or $1500 USD for stays of 7 or more nights


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In her young adulthood, she became a solo pilot, ending her flying career when she landed crosswise in a cornfield. She began her secretarial career in Warm Springs near the end of FDR's presidency. She met James Haman, married and moved into Georgia Tech as a residence counselor. Peggy was very involved as a wife, mother and Girl Scout leader. In her late 50s, Peggy returned to school at Georgia State to earn her registered nurse degree. She was a wonderful role model for all of the women in the family including the grandchildren. As a nurse, she worked in oncology and with hospice in Atlanta. When she moved to Rabun County in the mid-1980s, she worked to establish the first hospice in the county. After she retired for the final time, Peggy became very involved with St. James Episcopal Church as part of the vestry, altar guild and Daughters of the King. Peggy was also active with bridge and weaving in the community.
She is survived by: her husband, James B. Haman; and three daughters, Sarah Haman of California, Carol Walker of Texas and Laura Haman of New Mexico.
A memorial service will be held today at St. James Episcopal Church.
In lieu of flowers, memorial donations may be made to Community Pantry of Rabun County or St. James Episcopal Church.
Byars Funeral Home & Cremation Services in Cumming is in charge of arrangements. An online guestbook is available at www.byarsfuneralhome.com.


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Submission Watchdog examines BitCoin, MMOs' money laundering potential->
angry tapir writes: "Australia's anti-money laundering watchdog AUSTRAC believes that money laundering using digital currencies such as Bitcoin and virtual worlds (such as MMOs) are possible 'emerging threats'. The organisation's latest 'typologies' report earmarked virtual worlds and Bitcoin as two areas that the agency would be monitoring, although at this stage no-one seems sure to what extent they are being used (and some of the issues with Bitcoin, such as the fluctuating exchange rate and limited options for transferring value to real-world currencies through conversion to non-digital currencies or using it to pay for goods or services, mean that it's unlikely it's being used for money laundering on a significant scale)."
Link to Original Source
Link to Original Source


text:
Mike D'Antoni
Domenic Centofanti/Getty Images
News about Mike D'Antoni, including commentary and archival articles published in The New York Times.
Chronology of Coverage
May. 1, 2014
Mike D'Antoni resigns after less than two seasons as Los Angeles Lakers head coach, walking away from one year and $4 million left on his contract. MORE
Jan. 27, 2014
Harvey Araton On Pro Basketball column, in light of Los Angeles Lakers coach Mike D'Antoni's loss to the New York Knicks, explores why D'Antoni failed to gel with star Carmelo Anthony when he coached the Knicks himself. MORE
Dec. 14, 2012
Los Angeles Lakers coach Mike D'Antoni, former coach of the New York Knicks, is booed by fans at Madison Square Garden as Knicks top Lakers, 116-107. MORE
Dec. 13, 2012
Howard Beck On Pro Basketball column notes that Los Angeles Lakers coach Mike D'Antoni, who has lost three straight games, will return to New York to face his former team, the New York Knicks. MORE
Dec. 6, 2012
Harvey Araton On Pro Basketball column holds that Los Angeles Lakers are having tough time adapting to new coach Mike D'Antoni's offense style without guidance of point guard Steve Nash, who has been gone with fractured leg since second game of season. MORE
Nov. 21, 2012
Arrival of Los Angeles Lakers new coach Mike D'Antonio has forward Pau Gasol working on his adaptive skills; D'Antonio says he will count on Gasol, who has generally been a reliable midrange shooter, for 3-pointers. MORE
Nov. 18, 2012
Howard Beck On Pro Basketball column reflects on Linsanity as Mike D;Antoni prepares to make his Los Angeles Lakers coaching debut against Houston Rockets team led by point guard Jeremy Lin; notes D'Antonio and Lin made beautiful basketball together before New York Knicks parted ways with both of them nine months ago. MORE
Nov. 16, 2012
Mike D'Antoni, recovering from recent knee-replacement surgery, attends his first practice as Los Angeles Lakers new coach. MORE
Nov. 14, 2012
Howard Beck On Pro Basketball column asserts that coach Mike D'Antoni has a good chance to improve his reputation after being hired by Los Angeles Lakers. MORE
Nov. 13, 2012
Los Angeles Lakers hire Mike D'Antoni as their new coach, defying expectations that Phil Jackson might return; D'Antoni, formerly coach of New York Knicks, receives three-year, $12 million deal with Lakers holding option for a fourth year. MORE
Nov. 13, 2012
New York Knicks, including forward Carmelo Anthony, offer praise for former coach Mike D'Antoni as he accepts new position with Los Angeles Lakers, despite rocky end to his tenure in New York. MORE
Nov. 13, 2012
Harvey Araton On Basketball column contends that Los Angeles Lakers incoming coach Mike D'Antoni must prove that he has learned from mistakes he made as coach of New York Knicks; holds that D'Antoni, who clashed with Knicks star Carmelo Anthony, faces similarly large egos with Lakers. MORE
Mar. 22, 2012
Harvey Araton On Basketball column holds that New York Knicks star forward Carmelo Anthony's newly found enthusiasm and output under interim coach Mike Woodson, after the exit of Mike D'Antoni, is raising eyebrows and questions. MORE
Mar. 15, 2012
Harvey Araton On Basketball column asserts that New York Knicks coach Mike D'Antonio's resignation is no more than a formality, a good man cutting his losses from a no-win situation; holds that D'Antoni's exit was inevitable after Donnie Walsh resigned as Knicks president in June 2011; notes that the team has been mired in an era of confrontation and chaos since owner James L Dolan exerted his full control in 2001. MORE
Mar. 15, 2012
New York Knicks coach Mike D'Antoni resigns amid frustration, leaving in the middle of his fourth season, with the Knicks on a six-game losing streak and his offensive system at odds with the style of the star forward Carmelo Anthony; tension between D'Antoni and Anthony has been building for 13 months, since Anthony arrived in a controversial trade; assistant Mike Woodson will become interim coach. MORE
Feb. 14, 2012
Howard Beck On Basketball column holds that New York Knicks coach Mike D'Antonio may have found in guard Jeremy Lin the perfect driver to power his wide-open offense, just as Steve Nash once did under D'Antoni with the Phoenix Suns. MORE
Jan. 22, 2012
Profile of Phil Jackson, basketball Hall of Famer and winner of 11 NBA titles as a coach; although Jackson is happily retired, he has been mentioned as a replacement for New York Knicks coach Mike D'Antoni. MORE
Dec. 24, 2011
New York Knicks coach Mike D'Antoni must forge a title contender from a brand-new team that has had little time to develop much-needed chemistry or risk losing his job. MORE
Jun. 5, 2011
New York Knicks coach Mike D'Antoni's future with team remains unclear after Donnie Walsh's departure as Knicks president. MORE
Apr. 22, 2011
William C Rhoden Sports of The Times column argues that New York Knicks coach Mike D'Antoni does not deserve criticism being heaped on him; notes that D'Antoni has the Knicks in the playoffs for the first time since 2004, and asserts that he deserves another year on the job. MORE
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Steve Nash Stands on His Own as an Ideal of Team Play
Nash's artistry during the height of his abilities with the Suns stood out as the essence of individual expression connected to the welfare of the team.
March 23, 2015, Monday
MORE ON MIKE D'ANTONI AND: Basketball , Nash, Steve , D'Antoni, Mike , Phoenix Suns , Los Angeles Lakers
D'Antoni Resigns From Lakers
Mike D'Antoni resigned Wednesday after less than two seasons as the Lakers head coach, walking away from the one year and $4 million left on his contract.
May 1, 2014, Thursday
MORE ON MIKE D'ANTONI AND: Los Angeles Lakers , Coaches and Managers , Kupchak, Mitch , Basketball , D'Antoni, Mike
Nets and Collins Mostly Shrug Off Milestone Game
Jason Collins's teammates played down his return to the N.B.A. as the league's first openly gay and active player, acting as if it were just another normal night.
February 25, 2014, Tuesday
MORE ON MIKE D'ANTONI AND: Johnson, Joe , Kidd, Jason , Basketball , Brooklyn Nets , Collins, Jason , Pierce, Paul , Homosexuality , Williams, Deron , D'Antoni, Mike
Bench Empty, the Lakers Are Saved by a Technicality
When Los Angeles center Robert Sacre committed his sixth foul, officials informed the Lakers' coach of a rule that is rarely invoked: No team can have fewer than five players on the court.
February 7, 2014, Friday
MORE ON MIKE D'ANTONI AND: Officiating (Sports) , Cleveland Cavaliers , Sacre, Robert , Basketball , Los Angeles Lakers , D'Antoni, Mike
A Coach Returns, and the Questions Linger
Mike D'Antoni's return to New York, this time with the Los Angeles Lakers, brought back questions about why he and Carmelo Anthony failed as a tandem in New York.
January 27, 2014, Monday
MORE ON MIKE D'ANTONI AND: D'Antoni, Mike , Bryant, Kobe , Anthony, Carmelo , Los Angeles Lakers , New York Knicks , Basketball
Former N.B.A. All-Star Surrenders to Authorities
After leaving a hospital, the former N.B.A. All-Star Mookie Blaylock surrendered to the authorities and is in jail, charged with vehicular homicide in a crash south of Atlanta.
June 11, 2013, Tuesday
MORE ON MIKE D'ANTONI AND: Basketball , Blaylock, Mookie , Thibodeau, Tom , Williams, Monty , Boeheim, Jim , D'Antoni, Mike , McMillan, Nate
Faried Helps Nuggets Push Series to Game 6
Kobe Bryant, Pau Gasol and Coach Mike D'Antoni all believe Dwight Howard should stick with the Los Angeles Lakers.
May 1, 2013, Wednesday
MORE ON MIKE D'ANTONI AND: Basketball , Los Angeles Lakers , Howard, Dwight , Bryant, Kobe , Gasol, Pau , D'Antoni, Mike , Denver Nuggets , Golden State Warriors
Lakers Move From What Happened to What Now
After San Antonio swept them, the Lakers begin their off-season not knowing who will return next season. The biggest question remains the future of Dwight Howard.
April 30, 2013, Tuesday
MORE ON MIKE D'ANTONI AND: Basketball , Los Angeles Lakers , Howard, Dwight , Nash, Steve , D'Antoni, Mike , Bryant, Kobe , O'Neal, Shaquille
Lakers Will Lean on Frontcourt in Playoffs
With the Memphis Grizzlies' 86-70 victory over the Utah Jazz, the Lakers are bound for the playoffs, where they will rely on Dwight Howard and Pau Gasol.
April 18, 2013, Thursday
MORE ON MIKE D'ANTONI AND: Basketball , Los Angeles Lakers , Howard, Dwight , Gasol, Pau , Utah Jazz , D'Antoni, Mike
Lakers Lack Bryant but Not Confidence
Steve Blake, Jodie Meeks and Antawn Jamison played significant roles in a playoff-push victory over the San Antonio Spurs.
April 16, 2013, Tuesday
MORE ON MIKE D'ANTONI AND: Los Angeles Lakers , Bryant, Kobe , Basketball , D'Antoni, Mike , Howard, Dwight , Meeks, Jodie , Blake, Steve
'Awakenings' and Knicks? Now That You Mention It ...
The Knicks have followed the plot of the 1990 Academy Award nominee "Awakenings" so closely that James L. Dolan could be accused of plagiarizing Penny Marshall.
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JCYS offers educational, recreational and leadership experiences at our family centers, multiple summer camps and specialty programs that nurture each child's individual spirit, imagination, confidence and talents.
About JCYS
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As an independent organization, JCYS relies on donors to provide affordable programs to over 10,000 individuals. Your support means so much to our families and children we serve.
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Parent Corner
Wicker Park - Opening Fall 2016
In July 2015, JCYS broke ground on a fourth Family Center in Wicker Park.
The new Michael R. Lutz Family Center is scheduled to open in Fall 2016.


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Kentucky Lakes / Prizer Point KOA
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Reserve: 800-562-3701
Info: 270-522-3762
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I-24 to Exit 56: Go south on 139 to 276 West (Second right, about 2 miles). Take 276 W to T and turn left on 274 (about 6 miles). Take 274 to Prizer Point Road (First right about 1/4 mile). KOA is about 1.3 miles on right.Get Google Directions
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- Northern New York Newspapers
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POTSDAM Christopher J. Hughes, 32, of 236 Marsh Road, Norfolk, was charged by state police with petit larceny at 7 p.m. Friday. Mr. Hughes allegedly stole a television wall bracket and a coffee maker from Walmart, Route 11, on April 8. He was arraigned and taken to the St. Lawrence County jail, Canton, on $500 bail.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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By JOHN SERFUSTINISun Advocate associate editor
The Helper City Council Thursday awarded the contract for Area 4 of its infrastrure rebuilding to low bidder Terry Larsen Excavating of Utah County.
The firm had submitted a bid of $3,527,000. The bid is about $700,000 higher than anticipated in the original estimates, engineers from Franson Civil Engineers told the council.
As with the plan for Area 1, which was also higher than planned, the engineers will be working the city's utility departments to revise some aspects, according to Eric Franson and Chad Brown of Franson.
Area 4 is the neighborhood around Helper Junior High School, west of of US-6.
The engineers were confident that the entire project can be completed within its $19.5 million budget. They said this can be done without compromising the integrity of the culinary water, sewer and storm water systems.
For example, the Castle Gate subdivision has a much newer sewer system that the 70-year old parts elsewhere in Helper. That means only culinary and storm system construction will probably be necessary.
It may also be possible to lump all of next year's phases into a single contract.
Meanwhile, Condie Construction, which has the contract for Area 1, will begin on or about April 15. This area is basically central Helper east of the highway except for Main Street.
Condie will be working shifts of four 10-hour days. This should make it easier to accommodate the needs of the Arts and Music Festival in August.


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You can expect an upbeat and sophisticated evening at Hukama, with a choice of traditional provincial cuisines from China.
Gourmet ingredients such as caviar and lobster paired with authentic flavour combinations help to create a luxurious interpretation of fusion and contemporary Chinese cuisine.
Local delicacies such as pistachios are also creatively used in the menu and combined with common Chinese ingredients to provide an interesting twist and a new taste sensation. Definitely an adventure for the taste buds.
The décor of the restaurant is sophisticated and elegant with stylish Oriental touches. The private dining room with its heavy door and giant chandelier is a showstopper.
Price rating: $$$$
Address: The Address, Downtown Burj Dubai.
Opening hours: 17:00 to 00:00.
Tel: +971 4 4368888
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I am using sessions, and I redirect the from the login page to the main page if the user is registered. But I have a problem sometimes I can't log the user, so instead of redirecting the user using header('location: location.php'), I write a META tag and then redirect and give the page some time to create a session about 2 seconds. But still the problem does persist, And this happens only during the first time. Later everything works fine. And in the first time when i append the 'SID' to the page, The page url shows
appended to the file. and then I get 404 error, If i remove the PHPSESSID part, The page works as expected, But for the first time why does it show on the URL? which causes error.
I think Pejone or some Moderator had written about this, and that is the reason I redirect using meta tag, but still...


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It's not easy being green! In this BrainPOP movie, Tim and Moby discuss the process of photosynthesis! You'll find out how plants are helpful to humans, what makes plants green, and how plants make their own food. Learn what an important role the sun plays in photosynthesis; how solar energy is turned into chemical energy; and how plants create glucose, their main source of fuel. You'll also discover some important parts of a plant, including those that help make plant food. You know, not all plants say, "Feed me, Seymour!"
Learn More:What is photosynthesis?What job do carotenoids have in plants?How much energy do we get from plants?
See a Full List of Topics


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Walnut Bella "meatball" Subs with Balsamic peppers, tomatoes & shallots#23782
Breakfast fare in Singapore. Some say it tastes better when wrapped in brown paper!#23780
Apple Cinnamon Matzo Brei tastes so much like French toast! Just in time for Passover....or anytime!#23777
Peanut Butter & Jelly Crumb Bars - tasty and portable bars with the salty-sweet combination of the PB&J.#23776
Amaretto cream cheese stuffed inside giant strawberries and dipped in Bailey's Chocolate. Decorated like Easter eggs!#23774
From NPR... Starbucks Strawberry Frappuccinos have that certain crushed bug red color to them thanks to Cochineal.#23771
Creamy cheesecake is sandwiched between 2 layers of carrot cake & topped with cream cheese frosting.#23769
Bread, Oil and Anchovies. A version of a traditional Italian plate by famous chef Andrea Berton from the Trussardi alla Scala restaurant in Milan, Italy.#23768
A delicious way to prepare salmon - poached with a dill infused barbecue sauce
Everything you love about Girl Scout Samoas cookies in a decadent scone!#23763
An easy Mac & Cheese that takes about as much time as the boxed kind but tastes so much better!#23760
Strawberry Pasta Salad - with cucumbers, fresh mozzarella and basil, and a balsamic dressing. Perfect for picnics!#23759
Maple Bacon Marshmallows. Homemade marshmallows are far superior to the store-bought ones, especially when you fold in candied bacon bits!#23754
How to make the perfect concon, the popular Dominican crispy rice (Pegao in Puerto Rico).#23750
Cheesecake Filled Chocolate Easter Eggs - the easiest, quickest, no-bake treat you can make this Easter#23749
Chewy Ginger Cookies {Gluten-free}: A delicious gluten-free cookie that is easy to make and is made with ingredients you have on hand.#23748
Not sure you like Quinoa? One bite of these Quinoa Cakes w/ Goat Cheese and Slow Roasted Tomatoes will make you a believer!#23746
Sweetened with honey, a hint of orange, and a handful of raisins, these Hot Cross Buns are remarkable.#23741


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iHerb Customer Reviews
No More Tongue-Stripping Baked Goods! YAY!!
3 people found the following review helpful
Posted by Reviewer3000993 on Oct 28, 2013
I love to bake, but I was always wary of recipes that called for too much baking soda as I am sensitive to the after-taste, that tongue-stripping sensation. Stumbled across this product recently here ... and wow, what a difference it has made! I wouldn't have thought that the tongue-stripping sensation was due to the orange-box soda! Now I know, and I am having so much fun baking with this! Thank you.
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3 people found the following review helpful
Posted by Reviewer1156534 on Apr 08, 2011
this baking soda is awson I use to alkalie my system and the magnesium citrate with very good sucess. Was constipated but not anymore since using both product. thank you Iherb for your quick shipping been refering these two product to everyone that is constipated.
100 fantastic ways to use soda
3 people found the following review helpful
Posted by swinginstars on Aug 26, 2014
The most amazing thing about baking soda is that it's very cheap. It can be used not even for baking but also as an underarm deodorant, as a face and body scrub, as a toothpaste, for washing fruits and vegetables (removes chemicals), cleaning purposes and etc. You can do all these things for a very small cost. Baking soda is truly a miracle product, whether it's used for baking or not. Bob's Red Mill soda is aluminium free, which means it's 100% healthy.
3 people found the following review helpful
Posted by Reviewer2799475 on Jul 25, 2010
Excellent product. Please don't ever run out. Very reasonably priced and the shipping cost fantastic for all us international buyers. Joy
Glad to have my baking supplies.
2 people found the following review helpful
Posted by Reviewer2607859 on Feb 01, 2011
I can't get aluminum free baking soda in Holland, so I was glad to get a big bag of this, as I do a lot of baking.


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SDSU 1-2 in N.D.
The South Dakota State women's tennis team split two meets on Friday, but lost the weekend finale on Saturday in Grand Forks, N.D.
On Friday, SDSU edged cluster-host North Dakota 4-3, but Montana State won its season opener. In the weekend finale on Saturday, Montana was too much throughout the lineup and won 7-0.
Montana State 4 - SDSU 2
In its first dual of the day, SDSU had its opportunities, but was unable to overcome
The Jacks lost the team doubles point and it proved costly. Florencia Magni and Brooke Henry teamed up at No. 2 and eked out an 8-7 win versus Iva Parpunova (No. 2 singles) and Ellie Crum (No. 4).
SDSU sandwiched its doubles win, however, as the Bobcats won 8-5 at the top spot and 8-3 at No. 3 to win the team point.
In singles, Jenny Blackburne and Ffion Davies led the way with wins at No. 1 and No. 2, respectively. Blackburne needed only two sets to defeat Charlott Hjalarrson, 6-3, 6-2. Davies remained undefeated this season with a three-set, super tiebreaker win versus Parpunova, 3-6, 6-3, 10-3.
Montana State won at No. 3, in a super tiebreaker, No. 4 and No. 6 to reach a team decision.
"The meet versus Montana State was another match that could have gone either way," head coach Michael Engdahl said. "The next step for our program is to win matches like those against teams like MSU. We need to keep working and we will get there."
Due to time restraints, the meet concluded once a team decision was reached.
SDSU 4 - North Dakota 2
In its second dual of the day, SDSU won four singles matches to edge UND.
The Jacks faced North Dakota for the second time this school year. SDSU defeated UND 6-1 in Brookings on Sep. 28. The rematch was a bit closer, however.
North Dakota captured the team doubles point with wins at No. 1 (8-6) and No. 3 (8-5). Florencia Magni and Brooke Henry led 6-5 at the middle spot versus Sarah Stejskal and Stephanie Biehn, but the match was unfinished due to time constraints and a reached decision.
In singles, SDSU looked for wins from all over the lineup and found enough to win.
Ffion Davies, who was undefeated in singles entering the weekend, remained undefeated with her first win at No. 1. Davies once again needed a third-set super tiebreaker, but once again came out on top, defeating Stephanie Petsis 3-6, 6-4, 10-8.
Magni dominated the No. 3 match with a straight-set, 6-1, 6-1 win versus Stejskal. The two games were the least surrendered by a winner in the meet. Brooke Henry was also a straight-set winner at No. 6, defeating Mindy Lawrence 6-4, 6-1.
Beatriz Souza was the other Jackrabbit winner and, like Davies, needed a super tiebreaker to outlast Biehn 6-3, 3-6, 10-7.
The four singles wins were enough to overcome the doubles decision and edge North Dakota 4-3.
"Both matches this evening were battles," said Engdahl. "We had a longer meet versus Montana State and only 30 minutes to get ready for North Dakota. With that quick of a turnaround, it can be tough to find energy in doubles and we came out very flat. The girls should be proud of the way they bounced back and clawed their way to a win. It was a gut-check moment and it was nice to win a close meet."
Montana 7 - SDSU 0
In its third and final meet of the weekend, Montana was too much up and down the lineup in a 7-0 win.
Contrary to the scoreboard, SDSU won at No. 1 doubles. Jenny Blackburne and Ffion Davies proved to be a formidable opponent with an 8-6 win versus Heather Davidson and Laurence Pelchat. The Grizzlies won the other two doubles matches, however, and scored the team point.
In singles, Montana won in straight sets at each position. Beatriz Souza pushed Pelchat to the limit in the first set at No. 4, but lost 7-5, 6-1.
"We played 11 hours of tennis in 20 hours this weekend and the girls handled it well," head coach Michael Engdahl said. "Montana has a real solid program and for the amount of tennis the girls played, we hung tough. Jenny and Ffion played clutch in doubles and we are starting to see the close matches fall our way. The girls earned a few days off and will be ready to get back to work on Tuesday."
The weekend results set the Jacks record at 1-4. SDSU takes two weeks off from competition before traveling to Colorado for a weekend of meets.
SDSU visits Metro State in Denver on Saturday, Feb. 16, and Northern Colorado in Greeley on Sunday, Feb. 17. Meet times are set for 7 p.m. and 9 a.m., respectively.
Complete results are available at the beginning of this article.


text: 50 kids under 18 prescribed medical marijuana in Oregon Share this story email Share this story «Previous 3 of 8 Photos Next » Read the story « » Child Leukemia Medical Marijuana In this Friday Nov. 2, 2012 photo, Mykayla Comstock, 7, readies herself to swallow her medical marijuana dose, which she takes twice daily, in Gladstone, Ore. Mykayla's mother says she gives her daughter marijuana pills to combat the effects of chemotherapy, but her father, who lives in North Dakota, worries about the effects of the drug on her brain development. Mykayla was diagnosed with leukemia last spring. (AP Photo/The Oregonian, Beth Nakamura)


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eSeries Case (out-of-stock)
Out of Stock Product Number: 29186
Touch, Talk and Listen™ with Full Protection: These cases give your critical electronics submersible protection while still allowing you to operate them. Things you might find handy way out in the back of beyond. Available in three different sizes, they're completely transparent and feature tough urethane windows that are soft enough to let you easily navigate button-based interfaces. Each have a SealLock™ closure that ensures waterproof performance and two corner lash points that let you attach cords or anything else to keep your gear secure.
Fits a wide range of valuable gear, from phones and GPS units, to e-readers and tablet PC's, see sizing chart for information.
- Ultra-clear and supple urethane windows allow use of all touchscreen, camera and voice functions.
- Submersible Protection: Exclusive SealLock™ zip closure withstands submersion in 1 meter of water for 30 minutes. (Meets IP-X7 standards.)
- Individually tested: Unquestionable reliability ensures peace of mind.
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- Secure: Die-cut lash points at corners provide tethering options for high adventure or total convenience.
Gender: Unisex
Weight: See sizing chart
Material: outside 17.5x24.8 cm (6.9x9.8 in), 600D polyurethane coated polyester and clear PVC-free window
Dimensions: See sizing chart
Season: S12
Vendor ProductId: 6773
Review ProductId: 29186


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Home health care helps seniors live independently for as long as possible, given the limits of their medical condition. It covers a wide range of services and can often delay the need for long-term nursing home care.
More specifically, home health care may include occupational and physical therapy, speech therapy, and even skilled nursing. It may involve helping the elderly with activities of daily living such as bathing, dressing, and eating. Or it may include assistance with cooking, cleaning, other housekeeping jobs, and monitoring one's daily regimen of prescription and over-the-counter medications.
At this point, it is important to understand the difference between home health care and home care services. Although they sound the same (and home health care may include some home care services), home health care is more medically oriented. While home care typically includes chore and housecleaning services, home health care usually involves helping seniors recover from an illness or injury. That is why the people who provide home health care are often licensed practical nurses, therapists, or home health aides. Most work for home health agencies, hospitals, or public health departments that are licensed by the state.
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As with any important purchase, it is always a good idea to talk with friends, neighbors, and your local area agency on aging to learn more about the home health care agencies in your community. In looking for a home health care agency, the following questions can be used to help guide your search:
When purchasing home health care directly from an individual provider (instead of through an agency), it is even more important to screen the person thoroughly. This should include an interview with the home health caregiver to make sure that he or she is qualified for the job. You should request references. Also, prepare for the interview by making a list of any special needs the senior might have. For example, you would want to note whether the elderly patient needs help getting into or out of a wheelchair. If so, the home health caregiver must be able to provide that assistance.
Whether you arrange for home health care through an agency or hire an independent home health care aide on an individual basis, it helps to spend some time preparing for the person who will be doing the work. Ideally, you could spend a day with him or her, before the job formally begins, to discuss what will be involved in the daily routine. If nothing else, tell the home health care provider (both verbally and in writing) the following things that he or she should know about the senior:
Although most states require that home health care agencies perform criminal background checks on their workers and carefully screen job applicants for these positions, the actual regulations will vary depending on where you live. Therefore, before contacting a home health care agency, you may want to call your local area agency on aging or department of public health to learn what laws apply in your state.
The cost of home health care varies across states and within states. In addition, costs will fluctuate depending on the type of health care professional required. Home care services can be paid for directly by the patient and his or her family members, or through a variety of public and private sources. Sources for home health care funding include Medicare, Medicaid, the Older Americans Act, the Veterans' Administration, and private insurance. To learn more about paying for home care visit http://longtermcare.gov/costs-how-to-pay/
There are several national organizations that can provide additional consumer information about home health care services. These include the following:
To find out more about home health care programs where you live, you will want to contact your local aging information and assistance provider or area agency on aging (AAA). The Eldercare Locator, a public service of the Administration on Aging (at 1-800-677-1116 or http://www.eldercare.gov) can help connect you to these agencies.


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Available at Walmart, Sam's Club, Sprouts, Whole Foods and many more stores nationwide. Store Locator
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Fridge Magnets make outstanding marketing tools that grab attention anywhere they're placed, whether on a client's fridge, on toolboxes at a mechanic's shop or the office filing cabinet. Shop our selection of stock and custom shapes!
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Science Friday® is produced by the Science Friday Initiative, a 501(c)(3) nonprofit organization.
Science Friday® and SciFri® are registered service marks of Science Friday, Inc. Site design by Pentagram; engineering by Mediapolis.
In the past few years, scientists have drawn several parallels between stem cells and cancer cells. In tumor formation, formerly specialized tissue cells somehow become 'reprogrammed' to form tumor tissue. A similar reprogramming takes place in the creation of stem cells. Both types of cells also have an unusual ability to renew themselves. So what is it that lets a stem cell know it's a stem cell, and not a cancer cell?
In this segment, Joe Palca talks with stem cell researcher George Daley about the discovery of a protein that may help give stem cells their unusual multi-function abilities. The protein, named Lin-28, appears to help regulate the activity of certain small RNA molecules called "let-7 microRNAs" found in both stem cells and cancer.


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Sales Prospecting Training - Let us arm your sales team with a tactical playbook to get in the door with senior executives.
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How Can We Help You?
Sales Prospecting Training - Let us arm your sales team with a tactical playbook to get in the door with senior executives.
We're thrilled to announce Vorsight is ranked No. 3493 on the Inc 500||5000 Fastest Growing Companies for 2014!
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Improving your performance in the first half of the sales process is the key to everything that follows. It does not matter how effective your sales person is at closing if the quality and quantity of leads is not suitable to begin with. Vorsight's Sales Prospecting Training is designed to train your sales team to use tips, tactics and techniques to schedule qualified appointments with the decision makers your team needs to reach.
Vorsight has "arrived" as the inside sales training leader with a wide range of B2B clients whose sales cycles are shorter, and more productive today because of the Vorsight Sales Prospecting Training and techniques. Funded startups, mid-size companies, and units of large corporations that depend on outbound inside sales will benefit from Vorsight's training workshops.
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So whether you train your in-house inside sales force, or want a turnkey solution for lead generation and meeting setting…Vorsight has the solutions.
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In the days of Web 2.0, web sites are not only dynamic, they're fully interactive. From straightforward web presence to custom web applications, GeekGrl provides solutions to optimize the functionality of your web site. Let GeekGrl help you discover what your site can do for you!
GeekGrl focuses on simple, clean, modern designs which reflect the strengths and individuality of the client. We avoid using canned, stock photography and work to tie the site design closely to the marketing/identity plans to gain the maximum value from your web site investment.
Full service means exactly that. Along with helping you develop your web presence, GeekGrl provides services including: logo design, business card layouts, stationary/letterhead, promotional marketing materials and social media penetration.


text:
Welcome to Smogon! Check out the Smogon Info Hub for everything you need to know about starting out in the community. Don't forget to introduce yourself in the Introduction Thread, too!
Welcome to Smogon Forums! Please take a minute to read the rules.
The Double Battle Metagame (GBU)
Discussion in 'Global Battle Union' started by Ashenlock, May 14, 2011.
Page 5 of 13
Page 5 of 13


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Posted by Kevin Arnovitz on Sat, 05/06/06, 07:41pm:
Category: General
Posted by: Kevin Arnovitz
Ummm...I have no idea where they are, do you? They told me they'd be here around 7:30 or so and we looked everywhere, but I don't see them. And they didn't leave a message or anything. Have you heard from them?
Yeah, I know. Neither have I. And it's the weirdest thing, too, because that's all they were talking about all week -- how excited they were for this thing. They were really amped.
You know what? Let me take another lap, but if we don't see them soon I say we just get started without them.


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RVC competes in NJCAA Division III in men's and women's basketball, women's volleyball, golf, baseball, softball, men's and women's tennis, and men's and women's soccer. Not to brag, but we're pretty good at it. Our teams have won 13 national championships and we have had more than 140 All-Americans.
New Website! Check out our new Athletics website at rvcsports.com & sign-up for our e-newsletter!
Whether your plan is to take classes and transfer to a four-year university or enter one of our career programs designed to get you into the workforce right away, Rock Valley College has what you are looking for. Select from one of our more than 60 transfer areas or more than 30 career programs.
Online Schedule Check out RVC's online schedule for browsing course offerings!
Whether you are new to the college or know your way around, we have a variety of services designed to help you succeed. We're here for you every step of the way.
RVC Mobile App Download the RVC mobile app for your smartphone or mobile device!
At Rock Valley College, you're not just a number. Our highly respected faculty have master's degrees, doctorates and real-world experience. You won't be competing for attention in a huge lecture hall. Our average class size is 21, so you'll get a chance to interact, challenge and be challenged by your instructors.
Get Started! Find out what steps to take to start your journey at RVC...
The Estelle M. Black Library at Rock Valley College features over 91,000 book volumes and more than 650 periodicals, and access to the interlibrary loan system. It also features spaces for individual and group study, and if you get thirsty, there's a coffee shop in the lobby!
Have fun. Try stuff. RVC gives you opportunities to get involved. There are lots of student activities to choose from. We offer more than 20 clubs and organizations. Try your hands at student government. Join the staff of our campus newspaper. What's it going to be?
SL Handbook Your guide to getting involved at RVC! What are you waiting for?
Rock Valley College is home to a pair of renowned theater programs.
Summers come alive at RVC with Starlight Theatre, featuring four productions and held in the beautiful, and one-of-a-kind Bengt Sjostrom Theatre on the main campus. With its one of a kind retractable roof, every night is a perfect night for a show. Starlight brings some of the best known productions to Rockford, and in recent years has also debuted original works.
Studio Theatre enjoys a more intimate setting for productions throughout the winter. Whether it's a Christie murder mystery or an original work, audiences feel a part of the play.
Take a virtual tour of the Bengt Sjostrom Theatre


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text:
Intervale Component Jacket (Women's) (out-of-stock)
Out of Stock Product Number: 27372
An entire all-weather layering system in one great looking package, the women's Marmot Intervale Component Jacket combines a Marmot MemBrain® waterproof shell with a removable Marmoloft insulated liner and Storm hood. The color coordinated shell and liner both utilize a Durable Water Repellency finish, so with or without the liner you'll stay dry and warm.
- Marmot MemBrain® Waterproof/Breathable Fabric
- 100% Seam Taped
- Removable Storm Hood with Laminated Brim
- PitZips™
- Zippered Hand Pockets
- Internal Zip Pocket
- Elastic Draw Cord Hem
- DriClime® Lined Chin Guard
Gender: Women's
Weight: 3lbs 0.7oz (1380.6g)
Material: MemBrain 10 2L 100% Nylon 5.0 oz/yd - 100% Polyester DWR 1.8 oz/yd (Liner) - 100% Polyester Embossed WR 1.3 oz/yd - 100% Polyester WR 1.3 oz/yd (Liner) - Thermal R
Fit: Regular Fit
Dimensions: Center Back Length 27in
Season: F12
Vendor ProductId: 45620
Review ProductId: 19010


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LOCKPORT, NY - There's plenty of parks named after fallen heroes, soldiers, firefighters and police officers.
Usually it's not a controversial topic.
Buffalo police officer Patty Parete had such an outpouring of support after she was shot in the line of duty after her funeral this past February from spinal injuries. But, some her friends say they're having problems getting a park in Lockport named after her.
"That it's a crusade is a shame, I never intended for this to be a crusade and it shouldn't be," said Joe DiPasquale, who says he's on a journey to honor Parete, his life long-friend and former high school classmate.
Parete was shot and paralyzed in December 2006, while responding to a call. She was a Lockport native. She went to the city's high school in the 1980s.
DiPasquale says after Parete passed, some of her friends came up with the idea to name Rogers Avenue Park in Lockport after her -- honoring her life.
"Because we were so moved by this, by her death and so distraught over it," said DiPasquale outside his Buffalo home, "This should be a no-brainer. She is a daughter of Lockport, who should be honored with a park named after her."
Rogers Avenue was the only park DiPasquale says he could find that wasn't already named after someone else. In February, DiPasuqale says the city was receptive to the idea.
But now, City Council has denied naming the park after Parete.
"I was furious I was completely furious," DiPasquale said.
2 On Your Side went to Lockport Mayor Michael Tucker to get an explanation.
"We've had a lot of Lockportians die who have done a lot of great things for the city, I think what the city struggles with is you know how do you decide who's more qualified then the other?" Tucker said.
But, DiPasquale believes the explanation goes deeper than this and that the City Council will never honor Parete, in part because she's was a lesbian.
"Her sexual orientation - to say that it had nothing to do with it would be naive, to say that it would be the only reason would be too much," he said.
Mayor Tucker says that has never been an issue.
"No, it's totally irrelevant, never came up, don't care about it, this is 2013, we don't care about it," he said.
And instead, the city has set up a committee of local leaders to look at alternative locations to honor the brave officer.
In the past, Lockport has named parks after elected officials, business leaders and a WW II veteran. Mayor Tucker says the city will honor Parete, along with many other fallen Lockport heroes and has thrown out some possibilities like naming a park, a fountain or a plaza after them.
DiPasquale doesn't buy it.
And that's why he's setting up a rally at the Common Council's next meeting on Wednesday to demand that a Patty Parete Park be named.


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Peter Marsh, 79, of Borger, passed away, Sunday, May 8, 2011.
Peter Arthur Marsh was born Thursday, June 6, 1931 to Peter Paul Marsh and Leona (Kallenbach) Marsh in Brooklyn, New York. Mr. Marsh married Ethel Anderson on January 29, 1988 in Groom. Mr. Marsh worked for J. M. Huber as Head of Research and Development for many years, retiring in 1983. He then went to work for Northwestern Mutual Life Insurance Company as an insurance agent retiring with them in 1992. He was an active member of St. John's Catholic Church while his health allowed. He was instrumental in starting the Borger Stamp Club.
He is preceded in death by his parents; his first wife Patricia, on June 5, 1986 and a brother, Thomas Marsh.
Survivors include his wife Ethel Anderson Marsh, two sons Dr. Peter Marsh and wife Sabrina of Manvel, TX, Michael Marsh and wife Donda of Lubbock, TX, three daughters Mary Epps and husband Michael of Lubbock, TX, Eileen Karlin and husband Leo of Garland, TX and Ann Stanford and husband Steve of Panhandle, TX, step-children Renee Graves and husband Steve of Borger, TX, Blake Anderson and wife Sharon of Houston, TX and Chris Anderson also of Houston, TX, 19 grandchildren and 8 great grandchildren.
Mass will be held at St. John's Catholic Church at 11:00AM, Wednesday, May11, 2011 with Msgr. Michael Colwell officiating. Burial will follow at Westlawn Cemetery in Borger, TX.
Pallbearers will be Micah Graves, Eric Graves, Ian Anderson, Lane Stanford, Kyle Jones, and Dalton Marsh.
Mr. Marsh will lie in state at Brown Chapel Of The Fountains in Borger, TX on Monday, May 9, 2011 from 8:00AM to 8:00PM and Tuesday, May 10, 2011 from 8:00AM to 8:00PM.
Send personal condolences to www.brownfuneraldirectors.net [1].
[1] http://www.brownfuneraldirectors.net


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The origin of the energy released in fusion of light elements is due to an interplay of two opposing forces, the nuclear force which combines together protons and neutrons, and the Coulomb force which causes protons to repel each other. The protons are positively charged and repel each other but they nonetheless stick together, demonstrating the existence of another force referred to as nuclear attraction.
This force, called the strong nuclear force, overcomes electric repulsion in a very close range. The effect of this force is not observed outside the nucleus, hence the force has a strong dependence on distance, making it a short-range force. The same force also pulls the neutrons together, or neutrons and protons together.
Because the nuclear force is stronger than the Coulomb force for atomic nuclei smaller than iron and nickel, building up these nuclei from lighter nuclei by fusion releases the extra energy from the net attraction of these particles. For larger nuclei, however, no energy is released, since the nuclear force is short-range and cannot continue to act across still larger atomic nuclei. Thus, energy is no longer released when such nuclei are made by fusion; instead, energy is absorbed in such processes.
Research into controlled fusion, with the aim of producing fusion power for the production of electricity, has been conducted for over 60 years. It has been accompanied by extreme scientific and technological difficulties, but has resulted in progress. At present, controlled fusion reactions have been unable to produce break-even (self-sustaining) controlled fusion reactions.
Workable designs for a reactor that theoretically will deliver ten times more fusion energy than the amount needed to heat up plasma to required temperatures (see ITER) were originally scheduled to be operational in 2018, however this has been delayed and a new date has not been stated.
It takes considerable energy to force nuclei to fuse, even those of the lightest element, hydrogen. This is because all nuclei have a positive charge due to their protons, and as like charges repel, nuclei strongly resist being put close together. Accelerated to high speeds, they can overcome this electrostatic repulsion and be forced close enough for the attractive nuclear force to be sufficiently strong to achieve fusion.
The fusion of lighter nuclei, which creates a heavier nucleus and often a free neutron or proton, generally releases more energy than it takes to force the nuclei together; this is an exothermic process that can produce self-sustaining reactions. The US National Ignition Facility, which uses laser-driven inertial confinement fusion, is thought to be capable of break-even fusion.
The first large-scale laser target experiments were performed in June 2009 and ignition experiments began in early 2011. Energy released in most nuclear reactions is much larger than in chemical reactions, because the binding energy that holds a nucleus together is far greater than the energy that holds electrons to a nucleus.
For example, the ionization energy gained by adding an electron to a hydrogen nucleus is 13.6 eV—less than one-millionth of the 17.6 MeV released in the deuterium–tritium (D–T) reaction shown in the diagram to the right (one gram of matter would release 339 GJ of energy). Fusion reactions have an energy density many times greater than nuclear fission; the reactions produce far greater energy per unit of mass even though individual fission reactions are generally much more energetic than individual fusion ones.
which are themselves millions of times more energetic than chemical reactions. Only Direct conversion of mass into energy, such as that caused by the annihilatory collision of matter and antimatter, is more energetic per unit of mass than nuclear fusion.(wikipedia.org)


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Slightly grander than its sister hotel the Landmark, the Landmark Plaza Hotel is elegantly and intricately designed. The Landmark Plaza features tiled corridors with swirling patterns, and even the room windows are meringue-shaped, with some looking out over the rooftops to the sea.
The atrium lobby is magnificent and welcoming, with a sophisticated ambience combined with the liveliness of a shopping arcade – there are 50 shops based in the lobby. There are 127 rooms at the Landmark Plaza Hotel, and the staff are friendly and efficient.
Price rating: $
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text:
Following a Line
By Garrett Radke
February 21, 2013
I am an official National Park Service Photographer. A big part of my job is to capture moments of people appreciating our national parks. I am the photographer and the NPS owns the copyright to this picture. It has been made public domain and thus I have the right to give you permission to use it. This image captures a boy scout helping to lay out luminaries for the 2012 Illumination.
Related Parks
On September 17,1862, more than 23,000 soldiers were killed, wounded, or missing in the battle at Antietam, a pivotal battle in the Civil War. Visitors can take a self-guided 8.5 mile tour of the battlefield by car, bicycle or on foot. The park includes the Antietam National Cemetery, which honors 5,000 Union soldiers who died in the battle.


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Results 1 to 4 of 4
Thread: Sibsets
May 9th, 2013 12:36 PM #1
Right now we have 2 lovely little ladies Lilla Clare and Vivienne Grace. We have been talking baby names a lot lately since we are ttc baby #3(we have been for awhile) We think the girls are pretty well figured out but boys are harder, we like a lot of similar names.
For Girls we were thinking
Elinor June Cook
Penelope Kate Cook
we also like:
Not so keen on using because of Lilla
Not so keen on using because of Vivienne
We also like short middle names
For the boys
August or Atticus or Fergus or Rufus
DH really likes Atticus I really like August, we both like Rufus and we talked about using Fergus and Rupert together for a bit
Rupert or Rufus
Jasper or Oliver or Oscar
middle names
So I'm looking for some suggestions on sibsets about what names fit well together to help narrow down our list. Middle name suggestions are welcomed. We hope to have a large family so 3 girls names and 3 boys names would be wonderful.Mama to Lilla Clare 12/09 and Vivienne Grace 03/12
Tess Magnolia - Coming Nov 4th 2015
Scarlett Faye or Savannah Kate | Everett James or Knox Thomas
May 9th, 2013 01:26 PM #3
What a great list you have! With Lilla Clare and Vivienne Grace, I like:
Penelope Kate Cook (or even Penelope June) - I like June with your last name.
Elinor June
Henry Atticus or Henry Flynn
Theodore August or Theodore Rhys
I hope this helps!
Last edited by kyemsma; May 9th, 2013 at 01:28 PM.Anna Caroline & Grace Catherine
James Patrick & Luke Donovan
May 10th, 2013 11:02 AM #5
I like those combos they have a classic feel. I also had not considered pairing June with Penelope. We originally had Eleanor June picked out which looks lovely but we decided to go with the Elinor spelling instead and it doesn't look quite as pretty but Elinor Kate is quite nice as is Penelope June. Something to think about!Mama to Lilla Clare 12/09 and Vivienne Grace 03/12
Tess Magnolia - Coming Nov 4th 2015
Scarlett Faye or Savannah Kate | Everett James or Knox Thomas
May 11th, 2013 09:33 PM #7
Thanks so much for the input. DH and I talked and the names are:
Lilla Clare, Vivienne Grace, Elinor June, Penelope Kate, Rufus Graham, Jasper Rhys and Simon Jules
We love Elinor June while Jane Austin used both spellings we like how this one reflects the way we pronounce it
We really want to like Felicity, it fits with our girls names so well but it is just to hissy
We keep coming back to Penelope, I just swoon everytime I see it. Also over the years we have always paired a name ending in the ee sound with Kate, we just like the combo.
We understand that Rufus is not for everyone but we both love it. My husband Ross comes from a long line of Ralph's and we wanted to use a name that started with R to honor that.
Rupert was just a tad to serious next to Rufus and decidedly more british.
Jasper plays off of Rufus nicely. I feely like it is a very catish name while Rufus is very doggie
Oliver was just too popular
Simon just seemed to fit and we are very happy.
Thanks again your question and thoughts help us really see what we liked about each name or what we didn'tMama to Lilla Clare 12/09 and Vivienne Grace 03/12
Tess Magnolia - Coming Nov 4th 2015
Scarlett Faye or Savannah Kate | Everett James or Knox Thomas


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Beauty Product Of The Day « Read Less
After years of trying almost EVERYTHING on the market, I wanted to spotlight some of my favorite beauty products that I have to share with everyone. All the other Buzzmakers have their "OOTD" galleries, but I'd like to focus on my specialty which is everything beauty! Check out updates here for the best the industry has to offer.
11 of 19 (see all)


text: About Leather Gifts Under $50: Trying to find the perfect Gifts Under $50 for someone special or maybe just for yourself? Let us help you cut to the chase with our selection of affordable leather gifts for you to choose from! Photo holders, travel journals, front pocket wallets, checkbook holders, card cases, key rings and passport covers - they all make excellent gifts for important events such as an anniversary, birthday or graduation. Your gift recipient's face is guaranteed to light up when they open up a beautiful gift box filled with an exceptional leather gift just from you. Isn't it a joyous occasion when you can make someone else smile? We think so too!


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DERBY – After three and a half years, Brenda LePage, owner of Brenda's Restaurant, is moving her business from the Derby Road in Derby to Main Street in Newport City.
LePage opened Brenda's after a 15 year hiatus in the restaurant business. For 10 years, she owned LePage's, a popular breakfast and lunch spot, in Newport. This time, LePage is moving to the site of the former Junior's Restaurant, which is down the street from her old stomping grounds. LePage didn't want to move to her former Newport location, even though it's vacant, because it was too expensive to maintain.
There is a month's worth of work that LePage needs to complete before opening the doors on Main Street. In the meantime, she will continue her Meals on Wheels efforts at the American Legion in Newport. The Derby Elks Club also offered LePage kitchen space for the Meals on Wheels Program.
LePage opted to cook at the American Legion because she is more familiar with the kitchen. She will continue those efforts at her new location.
Brenda's Restaurant's last service in Derby will be tonight.
The seating in her new location is less than half of what she has now.
"I want to down size," said. "I would like to get back to doing what I used to do when I was on Main Street."
Once on Main Street, LePage will no longer be open for dinner. She will also offer grab-and-go food like coffee, bagels, donuts and muffins. Brenda's will serve breakfast and lunch six days a week and breakfast only on Sunday.
During her break in the restaurant business, LePage worked in property management in Bonita Springs, FL. She returned to Vermont when her father became ill. LePage said she can't stop working.
"I worked all my life," she said. "I have the energy."
LePage remains in the restaurant business so she can interact with people, which will be much easier at her new location with its partially open kitchen, something the Derby location doesn't have.
LePage hopes her cooking improved since she first graced downtown Newport. She likes to make as much as possible from scratch. This includes breads and soups.Â
LePage has been considering the move for a couple of months. "I was working about 100 hours a week here and it is hard to stop," she said.


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By RICHARD SHAWSun Advocate publisher
An envelope that had a powdered substance come out of it during handling operations at the Price Post Office on Thursday morning drew some concern from postal employees.
The situation was reported about 10 a.m. to the Price Police Department and the County Sheriff's Office, who sent a Hazardous Materials disposal team to the building.
The substance, however, turned out to be harmless.
"We examined the envelope and it turns out that someone put a powdered drink packet in it," said Jason Llewelyn, the director of the Hazardous Materials team. "I guess when it went through a mail sorting machine it just kind of went poof and spread the powder around."
All precautions were taken with a County Ambulance team showing up as well.
Generally those that send anything hazardous through the mail to someone doesn't put their address on the envelope. In this case the mailing had a return address on it.
The whole incident was resolved in less than an hour.


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Manuel Abeyta, fondly known throughout his teaching career as "Coach.", passed away peacefully surrounded by his loving family, on Sunday Aug. 4, 2013. Manuel was 85 years old.
Manuel was born in the town of Fruita, Colo., on June 20, 1928. He was the third child of 11 born to Andrew and Aurora (Dora) Abeyta.
His youth was spent with his brother, James, going to work with their father in the coal mines. During the summers, his father worked in the mountains taking the family with him. Fishing in the streams behind their cabin, camping out with his brother, James and Father under the Colorado sky were some of the fondest memories of his youth.
In 1950, Manuel joined the Navy, serving four years until 1954. He attended Idaho State, in Pocatello, Idaho, receiving a Bachelors of Science in Physical Education. In the following years, Manuel would go on to receive his Masters at the University of Utah.
On July 12, 1961, Manuel married Edith Wood. During this year, Manuel accepted a position at Ripon Unified School District as their Physical Education teacher for boys. Starting in September 1961 he was Ripon's High School Varsity Head Coach "Coach" of the Football, Basketball, Track and Wrestling teams for many years. He also served as Ripon's Athletic Director. These activities would take him and his "Coach Abeyta's Boy's" through numerous years of winning sports honors and trophies for Ripon High School. If you didn't know about "Coach" before high school, You did when you arrived.
Manuel loved hunting, fishing and his dogs. Pheasant season could never get here soon enough. Summers were spent fishing with family and friends and were a favorite activity during his younger years. Manuel was a member of the Lions Club, Quarterback Club, Sportsman Club, and a Veteran Of Foreign Wars.
After Retiring in 1993, Manuel spent time substitute teaching classes. Art was one of his favorites. His love of painting sports in action was a favorite pastime. Always the Coach at heart, you would see him at football and basketball games, he would be in the bleachers enjoying all those sports he loved.
Manuel was blessed to know his great-grandchildren during his lifetime, Zoe, Maya, Ella, Anthony, Ayden and Avery.
Manuel was preceded in death by his parents, Andrew and Aurora (Dora) Abeyta, his loving wife, Edith, his brother, James, and sisters, Pearl Lane and Pati Abeyta Olsen.
Manuel is survived by his step daughters: Allyn Costa and Janel Sharp, his step-son Daniel Wood, six grandchildren, six great-grandchildren, brothers, Harry Abeyta (Sally), David and Charles (Chuck) (Carolyn) Abeyta, sisters, Jennie Hansen, Loretta (Tom) Jewkes, Margaret (Marty) (George) Alves and Carol (Terry) Bland, and all of his numerous nieces and nephews.
There will be a Family Private Mass and Burial on Aug. 22, 2013 and a public celebration of life will be held on Aug. 22, 2013 from 2 to 5 p.m. at Spring Creek Golf & Country Club, Ripon, Calif.
A special thank you for all the many well wishes from the entire community who shared Manuel's life. You are not forgotten.
Donations in memory of Manuel can be made to: Pacifica Senior Living, 2325 St. Pauls Way, Modesto, Calif., 95355, or The Ripon Quarterback Club.


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Study to Collect Data on Fabry Disease Patients With Enhanceable Alpha-Galactosidase A Activity
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study will collect data needed to design a treatment trial for patients with Fabry disease using the experimental drug AT-1001. Fabry disease is an inherited metabolic disorder in which an enzyme called alpha-galactosidase A, which normally breaks down fatty substances called glycolipids, is missing or does not function properly. As a result, glycolipids accumulate in various tissues, causing liver, kidney, nerves, skin, muscle and blood vessel problems. No treatment is given in this survey study.
Males 18 years of age and older with Fabry disease who have certain genetic mutations associated with enhancement of alpha-galactosidase A activity may be eligible for this study. Participants undergo the following tests and procedures over 5 days:
Day 1
Medical history and physical examination, blood tests, electrocardiogram (EKG), routine urinalysis, measurements of height, weight, and vital signs (blood pressure, heart rate, breathing rate, and temperature).
Day 2
Blood tests, 24-hour urine collection, vital signs and sweat test. The sweat test (also called QSART, or quantitative sudomotor axon reflex test) measures the amount of sweat in a particular area of skin. A small amount of medication called acetylcholine is put on an area of the skin and a small electric current is applied to stimulate the sweat glands.
Day 3
Blood tests, 24-hour urine collection, vital signs, and skin biopsy. For the skin biopsy, a small area of skin is numbed and a punch device is used to remove a 3-mm (1/8-inch) layer of skin for microscopic examination.
Day 4
Blood tests, 24-hour urine collection, vital signs, and QSART.
Day 5
Blood tests and vital signs.
In addition to the above, patients are scheduled at some point in the 5-day study for an eye examination, brain magnetic resonance angiogram (MRA), and a heart examination and echocardiogram. MRA uses a strong magnetic field and radio waves to provide images of the blood vessels in the head and neck. It can detect abnormalities such as aneurysms, vessel malformations, and thickening of the vessel walls. An echocardiogram is an ultrasound test that shows how well the heart pumps blood and if there is thickening of the heart muscle.
Patients who are taking enzyme replacement therapy discontinue treatment for up to 6 weeks (no more than two missed infusions) to allow accurate measurement of the amount of alpha-galactosidase A the patient's body produces by itself. They provide weekly blood samples between the time they stop treatment and enter the study. The samples are used to monitor the removal of the enzyme from the body and the possible buildup of Gb(3) in the blood.
Fabry Disease
|Study Type:
|Official Title:
|A Study to Collect Normative Data on Fabry Disease Patients With Enhanceable Alpha-Galactosidase A Activity
|Estimated Enrollment:
|Study Start Date:
|March 2005
|Estimated Study Completion Date:
|March 2008
This protocol is designed to characterize the clinical and laboratory profile of patients with Fabry disease who have residual levels of Alpha-galactosidase (Alpha- Gal A) activity. Normally these are patients with the later onset or milder forms of the disease, sometimes referred to as the cardiac and/or renal variants. Enzyme Enhancement Therapy is a novel therapeutic approach to treatment of lysosomal storage diseases that has recently been proposed, for patients who produce low levels of endogenous enzyme. We plan to evaluate this therapy in later-onset Fabry disease patients and in preparation we need to develop sensitive outcome measures for this subset of patients. Thirty patients with enhanceable Alpha- Gal A activity will be recruited. If on enzyme replacement therapy, they will be asked to miss up to two biweekly infusions. These patients, along with five control patients with non-enhanceable(classic) Fabry disease, will undergo a comprehensive five day evaluation at the NIH Clinical Center that will include a complete physical examination, functional studies of the heart, eye, kidney and sweat function, imaging of the brain and the heart and a number of blood and urine tests, as well as a skin biopsy.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
- Age 18 and older males
- Patients will be included if they possess an Alpha-Gal A mutation that in previous investigations has been associated with enhancement of enzyme activity, as judged by the Principal Investigator.
- Patients whose general health prevents them from participating.
- Patients with significant disease unrelated to Fabry disease (e.g. diabetes, cancer).
- Patients who refuse to sign the informed consent form or who are unable to travel to the NIH Clinical Center.
- Patients who are currently participating in a clinical trial of small molecule or gene therapy for Fabry disease.
- Patients who are currently participating in a clinical trial for any condition other than Fabry disease.
- Patients who are judged by the Principal Investigator to be not qualified to participate.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00106912
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|ClinicalTrials.gov Identifier:
|NCT00106912 History of Changes
|Other Study ID Numbers:
|Study First Received:
|March 31, 2005
|Last Updated:
|September 26, 2015
|Health Authority:
|United States: Federal Government
Keywords provided by National Institutes of Health Clinical Center (CC):
Fabry Disease
Additional relevant MeSH terms:
Fabry Disease
Brain Diseases
Brain Diseases, Metabolic
Brain Diseases, Metabolic, Inborn
Cardiovascular Diseases
Central Nervous System Diseases
Cerebral Small Vessel Diseases
Cerebrovascular Disorders
Genetic Diseases, Inborn
Genetic Diseases, X-Linked
Lipid Metabolism Disorders
Lysosomal Storage Diseases
Lysosomal Storage Diseases, Nervous System
Metabolic Diseases
Nervous System Diseases
Vascular Diseases
Lipid Metabolism, Inborn Errors
Metabolism, Inborn Errors
ClinicalTrials.gov processed this record on October 13, 2015


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Moderators: Timko, Solty, Frank Delicious, Blake_T, Fritz, Booter
MrSpeedyB wrote:I like the Buzz and from what I've felt in the store the Avenger SS feels similar...so I think I'd like it.
Sounds like the Leo should hold a R-L line tho if I do it right with a slight anhyzer release? Should I also be able to throw it straight or with a L-R fade if thrown slightly hyzer? Should I try using the Valk for shots that need more fade?
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