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Welcome! Hope to see you at an event soon.
Featured Meetup
Laughter Yoga in Bromsgrove
Join us for a fun packed session of laughter yoga. Laughter yoga has many benefits, including strengthening the immune system, helping to stay fit ( 10 minutes laughter is equal to 30 minutes on a rowing machine!), and also reduces stress, anxiety , depression, high blood pressure and helps improve all around physical health. Session costs just £5 Learn more
- Wellbeing Bromsgrove, Wishing Well
- 16 St John Street, Bromsgrove, Worcestershire B61 8QY, Birmingham (map)
Featured Meetup
Spoken Word At The OrtOur Monthly evening of spoken word, poetry, stories, comedy and just a little bit of music ;) suggested donation of £3 a few open mic spots will be available on the night Learn more
Featured Meetup
Canal Walk and Sunday Lunch at the Black Eagle
This is another lovely Urban Walk with a Pub and Sunday Lunch at the end! Meet at Gas St Basin, under the Cast Iron Bridge near the Cafe from 12:00 for a 12:15pm prompt start (and I do mean prompt :-) ). We'll head out North along the Wolverhampton Canal as far as the Soho Loop. Here we'll veer off and walk all round the lovely Edgbaston... Learn more
- Gas St Basin
- Gas St, Birmingham (map)
Hosted by: Pete (Co-Organizer)
Featured Meetup
Meetup New Members Night And Social At The Garden House
Special Monthly Social Night dedicated to welcoming new Meetup peoples. Of course existing Meetup peoples also very welcome. From 7:30pm at the Garden House, 160 Hagley Road, Edgbaston, B16 9NX. The Garden House is opposite the Strathallan Hotel as you drive out of town on the Hagley Road. There is a spacious car-park at the rear of the pub,... Learn more
- The Garden House
- 160 Hagley Road, Birmingham (map)
Hosted by: Pete (Co-Organizer)
This Meetup repeats on the 2nd Wednesday of every month
Featured Meetup
Law Of Attraction & The Secret Workshop
Have you ever wondered what the law of Attraction or the secret was ? or How can it benefit you ? Have you been practicing the Law of Attraction and getting no where? This may be just the answer... This workshop will explain what the law of attraction is, how it may help you achieve your desired goals and also help with problems you may be... Learn more
- Slug and Lettuce
- 186-196 High Street, Birmingham, Harborne B17 9PP, Birmingham (map)
- More Meetups
Recent Meetups
Yesterday · 4:00 PMSka Sundays 1st Birthday Party at The Actress and Bishop*Free Entry* - Cheap selected drinks £2.50 until 8pm- Free Food - Free Cake! Top live music featuring - Skastuds- Those Fine Strangers ... and more! Hope you can... Learn more
2 days ago · 4:00 PMMoseley Pub CrawlThis event is open to everyone. Join us for the whole crawl or part of it, I know we had one last bank holiday but I thought I'll organise another one as its a great... Learn more
4 days ago · 7:30 PMEAT... Fantastic Indian meal the return!Hi members, You would normally know me from the WALKS I am organising this as a second curry night for you guys and girls at a great quite unknown brilliant Indian in... Learn more
September 28 · 7:45 PMCeroc classCeroc class basic and intermediate
September 25 · 7:30 PMLive Music at Two Towers BreweryAn evening of live, mostly acoustic music, in a brewery. Entry is £5, but this includes four tokens, which give you two pints of beer, or four halves, or four soft... Learn more
- See all past Meetups


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for dessert wines are harvested at slightly higher sugar levels
than those for table wines. Fermentation is stopped before
all the sugar can be converted to alcohol by the addition
of brandy. The wines are often aged in oak or stainless steel.
More Wine Education
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A good bottle of vino has the ability to balance and highlight your beef's flavor profile, elevating taste sensations to an entirely new level.
Fall has beer written all over it. Cool nights call for toasty flavored beers in colors matching the changing leaves.
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LYNCHBURG, Va. — In an unlikely appearance at a prominent Christian university, Democratic presidential candidate Bernie Sanders said Monday the "massive injustice" of income and wealth inequality should unite people across the political spectrum.
ATLANTA — Vice President Joe Biden said Thursday he was unsure if he will seek the Democratic presidential nomination, telling a Jewish audience that his decision will hinge on whether he and his family have the "emotional energy to run."
"Unless I can go to my party and the American people and say that I am able to devote my whole heart and my whole soul to this endeavor, it would not be appropriate," Biden said, responding to a question following a foreign policy address.
WASHINGTON — Sen. Bernie Sanders' presidential campaign said Thursday the Vermont Democrat has raised $15 million since joining the race in late April, a strong total for his challenge against front-runner Hillary Rodham Clinton.
About 250,000 donors have given money, giving the senator a solid foundation from which to build an insurgent campaign against Clinton and establishment Democrats.
WASHINGTON — Jim Webb, a decorated Vietnam veteran and accomplished novelist who became a fierce critic of the Iraq war in the Senate, announced Thursday that he's challenging Hillary Rodham Clinton and other rivals for the Democratic presidential nomination.
Webb, in a statement posted on his campaign website, acknowledged he would face major hurdles but vowed to bring an outsider's voice to the 2016 race, dominated by Clinton.
BALTIMORE — Former Maryland Gov. Martin O'Malley entered the Democratic presidential race on Saturday in a longshot challenge to Hillary Rodham Clinton for the 2016 nomination, casting himself as a new generation leader who would rebuild the economy and reform Wall Street.
"I'm running for you," he told a crowd of about 1,000 people in a populist message at Federal Hill Park in Baltimore, where he served as mayor before two terms as governor. O'Malley said was drawn into the campaign "to rebuild the truth of the American dream for all Americans."
PORTSMOUTH, N.H. — For Democrats who had hoped to lure Massachusetts Sen. Elizabeth Warren into a presidential campaign, independent Sen. Bernie Sanders might be the next best thing.
LAS VEGAS — Democratic presidential candidate Hillary Rodham Clinton intends to draw an early distinction with Republicans on illegal immigration, pointing to a pathway to citizenship as an essential part of any overhaul in Congress.
WASHINGTON — Hillary Rodham Clinton used a personal email account during her time as secretary of state, rather than a government-issued email address, potentially hampering efforts to archive official government documents required by law.
Clinton's office said nothing was illegal or improper about her use of the non-government account and that she believed her business emails to State Department and other .gov accounts would be archived in accordance with government rules.
WASHINGTON — The foundation launched by former President Bill Clinton more than a decade ago has battled HIV and AIDS in Africa, educated millions of children and fed the poor and hungry around the globe. It also has the potential to become a political risk for Hillary Rodham Clinton as she moves toward a second presidential campaign.
WASHINGTON — Hillary Rodham Clinton offered praise for President Barack Obama's executive actions to stave off deportation for millions of immigrants living in the U.S. illegally. But the Democrats' favored presidential hopeful has been less forthcoming on other issues in these early days of the 2016 contest.
Clinton is not, so far, a candidate, and she's limiting her commentary about the daily news cycle confronting Obama — a strategy that could keep down chatter about where she and the unpopular president agree and where they diverge.
WASHINGTON — Former Florida Gov. Jeb Bush is "moving forward" on a potential 2016 White House run and it appears more likely he will enter the Republican field, according to his son, who's running for office in Texas.
George P. Bush told ABC's "This Week" that his father is "still assessing" a presidential bid, but suggested it was more likely that he would seek the White House this time. The ex-governor declined to run for president in 2012 despite encouragement from Republicans.
St. Augustine Record ©2015. All Rights Reserved.


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2004 - 2015 Archives
Audi is making pedestrians in Belgium feel like fugitives on the run with a giant A4 billboard that tracks them through the street at night.
Acura is restoring a 1993 Legend owned by actor/rapper Ludacris for the SEMA show this year, and bringing a couple of Galpin customs as well.
Piece-Arrows and Duesenbergs top the list of Brass Era and Classic Era automobiles that sold at RM Sotheby's auction in Hershey, PA, this year, setting a new record for the event at over $16 million.
On paper, the M2 looks to be a super-M235i, buffed up with M Division goodies like an active rear differential and lightened suspension components.
GM is recalling 10,000 examples of the Buick Rainier, Chevrolet Trailblazer, and GMC Envoy because they don't have the right fix for an earlier safety campaign.
We take a ride in the sportiest ATS to see how this high-powered sedan behaves on the street, where it will spend most of its time.
Former Volkswagen CEO Martin Winterkorn still serves as chairman of Porsche SE, Audi, Scania, and Truck & Bus GmbH. But he's expected to resign from those posts soon as well.
On Episode #451 of the Autoblog Podcast, we'll be discussing the Ford Focus RS, Volvo's autonomous vehicle safety pledge, and the Toyota S-FR.
Porsche is sending Klaus Zellmer, the man responsible for so many of its overseas markets, to Atlanta to replace the new global sales chief Detlev von Platen as president and CEO of Porsche Cars North America.
Tesla claims two journalists from the Reno Gazette-Journal entered the Gigafactory land illegally, then hit and injured two workers before being arrested.
Owners of VW diesels and those who might want one aren't sure what to do. We lay out the things to think about if you're looking to buy or thinking of unloading.
New York Times correspondent Jack Ewing is writing a book about the Volkswagen emissions scandal, and has already sold the publishing and film rights,with the latter picked up by Paramount and Leonardo DiCaprio's studio Appian Way.
Volkswagen is announcing a big push towards electrification in the future, and headlining the new models is a next-gen EV Phaeton.
The Aficionauto drives Biff's 1946 Ford from the famous manure scene in the original Back to the Future, and invites you along for the surprisingly odorless ride.
BMW makes a big change with its smallest crossover, and few buyers are likely to notice. We drive the Bimmer that breaks with years of tradition.
A paramedic in Tennessee responded to an emergency call earlier this month while still wearing her flowing white wedding dress.
Nissan North America's manufacturing and supply chain boss doesn't consider Tesla an industry disruptor, but Uber is. He's not worried about Google or Apple, either.
RM Sotheby's has consigned for its upcoming New York auction a rare 1962 Aston Martin DB4 GT Zagato - expected to sell for over $16 million - along with notable classics from Ferrari, Bugatti, Siata and Lamborghini.
A rare Lamborghini Miura SVR Jota conversion is currently for sale in Japan, and this wild-looking, vintage supercar is absolutely immaculate.
Honda has been spotted testing the next-generation Civic Type R at the Nurburgring, complete with a monstrous rear wing and even more power than the current model.
Ford is preparing four very different custom takes on the Explorer Sport crossover for this year's SEMA show in Las Vegas.
A more extreme take on the F12 Berlinetta, the new TdF packs more power, less weight, higher downforce, and a new four-wheel steering system that Ferrari calls the Virtual Short Wheelbase.
Toyota finally shares some technical details about the 2016 Prius, including that the new hybrid will have, "impressive driving dynamics."
Jay Leno is back in his garage this week for an in-depth look at the 1964 Porsche 356 restomod that looks entirely stock from the outside.
No voice over. No host in your face. Nothing but the cars you want to see, in glorious high-definition video. Today's subject is the 2016 Honda Accord EX Sedan. Enjoy.
A Stanford University professor behind the autonomous Audi racer is now doing real-world experiments to examine vital ethics questions.
The following day after being reassigned to running fleet operations, former Fiat brand chief Jason Stoicevich reportedly left FCA altogether in the wake of flagging sales.
The Audi TT RS has been spied testing near the Nurburgring with a more aggressive, camouflaged body and bigger brakes.
Backed by popular demand, McLaren is considering building a convertible version of the 675LT after all, with lower weight, more power, and a higher price than the 650S Spider.
Uber and Lyft are fighting potential legislation that would mandate fingerprint background checks for its drivers in Austin, TX.


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There are no Upcoming Shows listed for this comedian.
Ester Steinberg
Ester Steinberg is hot off the Montreal Just For Laughs New Faces showcase. You can watch her every week on the hit reality series "Funny Girls" on Oxygen where she is mentored by Bill Burr and Margaret Cho. She started doing stand-up on the high school lunch tables in Tampa then moved to New York and attended NYU's theater program where she spent her nights performing in the New York comedy scene. Ester currently resides in Los Angeles where she performs regularly at the Comedy Store, Hollywood Improv, and Meltdown. She hosts her own monthly show at Canter's Kibitz Room frequented by comedians such as Bill Burr, TJ Miller, Hannibal Buress, Jeff Ross, and Natasha Leggero. Ester has been featured in Time Out New York, Nylon, E!, Variety, Glamour, and Entertainment Weekly. She writes and stars in "Becoming LA," a web series showcasing her talent for sketch and improv through an array of outlandish characters.Her festival credits include Montreal Just for Laughs, Bridgetown Comedy Festival, and Laughing Skull. Her style of comedy is smart and witty with immense energy, theatrical character act-outs and edgy one-liners.
Ester Steinberg's Upcoming Shows
Ester Steinberg is Known For
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- RT @ComedyJuiceNY: NYC! Tonight at @GothamComedy 9:30: @ChristFinnegan, @hasanminhaj, @wilsylvince, @TheFullCharge & More! #NYC TIX: http:… Oct 06
- RT @HelpUSA: TONIGHT: Join @macantone @JewdyGold for a private 'Meet & Greet' at our Comedy Club event 10/6! @GothamComedy http://t.co/pCR… Oct 06
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- RT @FlexAforeal: Hey New York I'll be hosting @AXSTV @GothamComedy October 8th 10pm hope to see you there!! pic.twitter.com/i9LdAFGuLG Oct 05
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Bring unique style to your home with this Disc Pendant lamp from Graypants. Stunning in design, it's crafted from repurposed cardboard that has been laser cut and assembled by hand. Due to the handmade process, slight variations in colour or corrugation pattern may occur. This fabulous light instantly updates any room in your home and creates stunning refractions when lit. Please note that Scraplights are not meant for damp conditions or outdoor use and for cleaning Graypants recommend a quick spray with a can of compressed air is best to remove dust. All shades are treated with a non-toxic fire retardant, to reduce the risk of fire only use a recommended bulb.
Item for UK delivery only
Free Standard Delivery to UK Addresses*
UK Next Working Day delivery is £5.95
UK Saturday delivery is £9.95
UK Sunday delivery is £9.95
There aren't any reviews for this product yet. Here are our service scores:
Amazing service as always. All items are for gifts.
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fast delivery on a product that was being delivered internationally. value in item as it was much lower than other online merchants.
So nice to get through easily to a real person when you need to. A very helpful service was provided.
The plates arrived broken and in multiple pieces - how do I now proceed? Do you want me to send you the pictures of the broken plates as I would like replacements sent. Best, Jeremy.
Extended wait for product due to factory fault, but Amara provided ongoing updates on my order status.
My order came incomplete- without the hooks for hanging. I am still waiting to a response from my email.
Amara are planning to charge a fee despite my dissatisfaction with my order. I will not order from Amara again.
good service
all arrived on time
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UK Sunday delivery is £9.95


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SALT LAKE CITY — The Mayor's Office of Diversity & Human Rights and the Utah Hispanic Chamber of Commerce will host the seventh annual Diverse Business Day at the state Capitol on Thursday, March 14, from 9 a.m. until noon.
Lorena Riffo-Jenson, founder of marketing and public relations firm VOX Creative, will provide the event's keynote address. Riffo-Jenson has spent more than two decades working in both the public and private sectors. She managed Utah's hosting program for the 2002 Winter Olympics and served as the marketing manager for Envision Utah, a public-private partnership that seeks to open the channels of communication between Utah's residents and elected officials.
Attendees will participate in an advocacy training led by Luis Garza of Comunidades Unidas, a community organization that promotes grass-roots outreach, education and capacity building.
The event will take place in the East Senate Building, Level 1, Olmstead Room 115. Attendance is free and open to the public. RSVP at 801-535-7704 to attend.
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Micheala in Tweed Heels
Photographed by Jipsy
Name: Micheala
Occupation: International Flight Attendant
Where are you from? Born in Germany but I live in Switzerland.
What brings you to Miami? My boyfriend lives here, so I stopped by. I literally just flew in 30 minutes ago.
When your in Miami, what do you enjoy the most from the city? The beaches!
Describe your style. There's no specific style. It all depends on my mood. Whatever I feel like dressing up in.
What were you listening on your way here? Well, I just got off a plane, so I was catching up with my friend who picked me up and brought me here.
Spotted at CIFO's View Poin 2011 Opening
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Northview Church Nicaragua GO Trip
In a way, "GO Trip" sounds like a redundant term, doesn't it? If you take a trip, you certainly go somewhere. If you go somewhere, you must make a trip of some sort. In this case, GO stands for "Global Outreach." Christians in many countries live in areas that are either very poor or underserved. They have many needs that might go unfulfilled without the aid of other Christians around the world who come alongside to serve them.
In June, Dave Choutka, Northview's Greater Lafayette Campus Pastor, led a GO Trip to Managua, Nicaragua. He made his first trip to Nicaragua in 2009, along with the previous outreach pastor, K. Paul Maurer. During this trip the two learned how Northview could better partner with the people there. Reflecting on that trip, Choutka says, "I felt drawn to be a part of what God was doing in Nicaragua from that first trip." Since then, he has led a team to Nicaragua each of the last six years, three of which were student trips comprised of students from Northview's Student Ministry.
This past trip was extra special for Choutka; he was asked to officiate the wedding of a couple he had met on a previous trip to Nicaragua. Two years ago, Choutka met Ever and Norary, as he helped build their home. He stayed in touch with the couple and throughout the past two years has seen their lives transformed as they accepted Christ into their lives.by Read More


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Dierks Bentley with Chris Young
Thu, Sep 25, 2014 7:00 pm
PNC Pavilion at Riverbend Music Center, Cincinnati, OH
Sorry, this event has already taken place. Please see similar events below.
|Nov 1 Sun 2:00 PM
|Miles and Music for Kids
|Ascend Amphitheater
Nashville, TN
|Nov 11 Wed 7:30 PM
|Stars And Strings
|Chicago Theatre
Chicago, IL


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MSNBC Live 02/11/14
'Lean in' starts with positive images
Getty Images and Sheryl Sanberg are partnering to change the perception of women as portrayed by stock images. ... more Duration: {{video.duration.momentjs}}
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Originally posted on Fox Sports West | By Abbey Mastracco | Last updated 7/16/14
GLADSTONE, NJ - JUNE 30: Annika Sorenstam of Sweden waits on the fourth tee during her match with Joanne Morley of England during the first round of the HSBC World Match Play at Hamilton Farm Golf Club June 30, 2005 in Gladstone, New Jersey. (Photo by Scott Halleran/Getty Images)
STATELINE, Nev. -- Former MLB pitcher Rick Rhoden has seven trophies from the American Century Celebrity Golf Championship in his case. Former NFL quarterback Rick Rhoden has four. The two of them were feeling pretty good about themselves and their odds to add more hardware this week at Edgewood Tahoe Golf Course until they heard how many trophies this year's top tournament newcomer has: 89. Former LPGA Tour player and Hall of Famer Annika Sorenstam is coming out of retirement this week to play in the heralded celebrity event and she has a few former champions comparing athletic achievements. "She never got Mike Schmidt out. That's the way I look it," joked former MLB pitcher and seven-time American Century Champ Rick Rhoden. "We don't have any of those kind of trophies at our house. I might have an AllâStar team ball or something, but I don't have any major trophies." "I've got a John Elway autographed jersey," defending champ and former NFL quarterback Billy Joe Tolliver offere...
PLAYERS: Annika Sorenstam, Rick Rhoden, John Elway, Jerome Bettis, Mark Rypien
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Burger King is in talks to buy Tim Hortons and form a new publicly listed company based in Canada.
Burger King is in talks to buy Tim Hortons and form a new publicly listed company based in Canada.
The two fast-food companies announced Sunday that Burger King majority owner 3G Capital would continue to own the majority of shares of the new company, with the remainder held by shareholders of Tim Hortons and Burger King.
The companies say Miami-based Burger King Worldwide Inc. and Ontario-based Tim Hortons Inc. would continue to operate as separate brands but would share corporate services.
The Wall Street Journal first reported the talks and that the companies say there's no assurance a deal will happen.
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The new company would have 18,000 restaurants in 100 countries with about $22 billion in sales. The companies say that would make it the world's third-largest fast-food restaurant company.


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One of the most magical and simple effects to create on stage is a "peel," where a series of fixtures makes changes, one after the other. For instance, let's say you want to move 12 fixtures from a U.S. position to a DS position. If you simply do this with a fade time of 10 seconds, they will all begin at the same moment, travel at the same speed and end at the same time. However, if you assign each fixture a unique position fade time that is slightly greater than the previous fixture, then the look will be very different. Now they will all start at the same moment, but move at different speeds and different end times. If instead of assigning these consecutive times to the fade time you used the delay time, then all the fixtures would move at the same speed, but start and end individually. By staggering the delay times, very interesting changes can easily be created. You can further vary the look by staggering the values in different orders (left to right, random, in pairs).
—Brad Schiller, from "Feeding the Machines," PLSN, July 2015


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Wednesday, October 1, 2015
The water level below Beaver Dam has dropped significantly, allowing Fly Fisherman and Bait Fisherman alike, to fish numberous areas. Fly Fishing has been excellent on midges in sizes of 16's/18's, wollybuggers, micro jigs in olive or brown. The water is super clear so insure you use flurocarbon tippets in 6x or 7x.
Bait Fisherman using power bait should use white, chartruse, red or sunrise, hatchery formula.
Don't miss out of the FREE Entry into the One Fly Tournament, October, 17th. Lunch is also FREE up at Spider Creek Pavillion, catereed by Anglers Grill, so come on out, enjoy a day of fishing, FREE lunch and an opportunity to cash in on over $ 1000.00 in prize giveaways to the top placing fisherman.
Fly Tackle:
• Micro Jig under a strike indicator
• PJ's Jig (...we landed a very fat 17" rainbow last week.)
Conventional Tackle:
• Rapala Crank baits
• Flicker Shad
• Worms with white and yellow power bait
• Colorado and Little Cleo Spoons
Good luck! Bring us a fish story.
Lisa, Tom, Carl, Ken & Nancy
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Town Square
Iron Horse Trail: too much horse manure!!
Original post made by Hal Bailey, Alamo, on Sep 1, 2009
It is time that horse owners clean up the manure left by their animals in the same manner as dog owners. The trail is becoming an ugly odor of horse manure left on the ground by owners without consideration for neighbors.
There are options to file notice with EBRPD that horse manure is now considered hazmat material by recent university studies. The affect would be restriction of horses from the trail.
Horse owners, please simply pick up after your animals.
Comments (2)
a resident of Danville
on Sep 2, 2009 at 1:13 am
As a frequent user of the trail, I agree with Hal. It's ironic that should the need arise to tap a kidney during one of my frequent sojourns between Danville and Walnut Creek, I must "hold it", while horse owners' animals leave piles of unsightly, stinking manure that might even gag a maggot. This is indeed the definition of arrogance. Perhaps these horse owners should be required to leave their addresses in a log at the trail head so that we can use their properties to relieve ourselves.
a resident of Blackhawk
on Sep 2, 2009 at 7:58 pm
Ditto that,Marcus!
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Are you V J Dzau?Claim your profile
Publications (488)3810.71 Total impact
Article: Tracking mesenchymal stromal cells using an ultra-bright TAT-functionalized plasmonic-active nanoplatform[Show abstract] [Hide abstract]
ABSTRACT: High-resolution tracking of stem cells remains a challenging task. An ultra-bright contrast agent with extended intracellular retention is suitable for in vivo high-resolution tracking of stem cells following the implantation. Here, a plasmonic-active nanoplatform was developed for tracking mesenchymal stromal cells (MSCs) in mice. The nanoplatform consisted of TAT peptide-functionalized gold nanostars (TAT-GNS) that emit ultra-bright two-photon photoluminescence capable of tracking MSCs under high-resolution optical imaging. In vitro experiment showed TAT-GNS-labeled MSCs retained a similar differentiability to that of non-labeled MSCs controls. Due to their star shape, TAT-GNS exhibited greater intracellular retention than that of commercial Q-Tracker. In vivo imaging of TAT-GNS-labeled MSCs five days following intra-arterial injections in mice kidneys showed possible MSCs implantation in juxta-glomerular (JG) regions, but non-specifically in glomeruli and afferent arterioles as well. With future design to optimize GNS labeling specificity and clearance, plasmonic-active nanoplatforms may be a useful intracellular tracking tool for stem cell research.Journal of Biophotonics 10/2015; DOI:10.1002/jbio.201500173 · 4.45 Impact Factor
Article: Blockade of Angiotensin II Type 2 Receptor by PD123319 Inhibits Osteogenic Differentiation of Human Mesenchymal Stem Cells via Inhibition of ERK Signaling[Show abstract] [Hide abstract]
ABSTRACT: Recent evidence indicates that the vasculature contains mesenchymal stem cells (MSCs). We hypothesized that angiotensin II (Ang II) type 2 receptors (AT2Rs) play a role in the osteogenesis of MSCs and may have a role in vascular calcification. Human MSCs were differentiated into osteoblasts. Expression of AT2R was significantly increased during osteogenesis, whereas the expression of Ang II type 1 receptors was not significantly changed. Incubation with the AT2R blocker PD123319 with or without Ang II significantly inhibited calcium deposition, whereas type 1 receptor blocker valsartan had no significant effect. PD123319 inhibited extracellular signal-regulated kinase (ERK) phosphorylation in the osteogenic process, whereas valsartan had no effect. Furthermore, PD123319 combined with Ang II also inhibited acute ERK phosphorylation in MSCs induced by insulin. In conclusion, AT2R is upregulated during osteogenesis. Blockade of AT2R inhibits osteogenesis and ERK phosphorylation of human MSCs. These results provide a novel insight into the pathophysiology of calcific vascular disease. Copyright © 2015 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.Journal of the American Society of Hypertension (JASH) 06/2015; 9(7). DOI:10.1016/j.jash.2015.06.006 · 2.61 Impact Factor
Article: Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways[Show abstract] [Hide abstract]
ABSTRACT: Wnt signaling has recently emerged as an important regulator of cardiac progenitor cell proliferation and differentiation, but the exact mechanisms by which Wnt signaling modulates these effects are not known. Understanding these mechanisms is essential for advancing our knowledge of cardiac progenitor cell biology and applying this knowledge to enhance cardiac therapy. Here, we explored the effects of Sfrp2, a canonical Wnt inhibitor, in adult cardiac progenitor cell (CPC) differentiation and investigated the molecular mechanisms involved. Our data show that Sfrp2 treatment can promote differentiation of CPCs after ischemia-reperfusion injury. Treatment of CPCs with Sfrp2 inhibited CPC proliferation and primed them for cardiac differentiation. Sfrp2 binding to Wnt6 and inhibition of Wnt6 canonical pathway was essential for the inhibition of CPC proliferation. This inhibition of Wnt6 canonical signaling by Sfrp2 was important for activation of the non-canonical Wnt/Planar Cell Polarity (PCP) pathway through JNK, which in turn induced expression of cardiac transcription factors and CPC differentiation. Taken together, these results demonstrate a novel role of Sfrp2 and Wnt6 in regulating the dynamic process of CPC proliferation and differentiation, as well as providing new insights into the mechanisms of Wnt signaling in cardiac differentiation. Copyright © 2015. Published by Elsevier Ltd.Journal of Molecular and Cellular Cardiology 06/2015; 85. DOI:10.1016/j.yjmcc.2015.06.003 · 4.66 Impact Factor
Article: MicroRNAs and Cardiac Regeneration[Show abstract] [Hide abstract]
ABSTRACT: The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling by fibroblasts, resulting in the eventual deterioration of cardiac structure and function. Cardiac function would be improved if these fibroblasts could be converted into cardiomyocytes. MicroRNAs (miRNAs), small noncoding RNAs that promote mRNA degradation and inhibit mRNA translation, have been shown to be important in cardiac development. Using this information, various researchers have used miRNAs to promote the formation of cardiomyocytes through several approaches. Several miRNAs acting in combination promote the direct conversion of cardiac fibroblasts into cardiomyocytes. Moreover, several miRNAs have been identified that aid the formation of inducible pluripotent stem cells and miRNAs also induce these cells to adopt a cardiac fate. MiRNAs have also been implicated in resident cardiac progenitor cell differentiation. In this review, we discuss the current literature as it pertains to these processes, as well as discussing the therapeutic implications of these findings. © 2015 American Heart Association, Inc.Circulation Research 05/2015; 116(10):1700-1711. DOI:10.1161/CIRCRESAHA.116.304377 · 11.02 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Personalised medicine has generated global policy interest in the past few years. In 2012, the European Union established the European Alliance for Personalised Medicine with the aim to accelerate the development, delivery, and uptake of personalised health care, broadly defined. In the same year, the UK's Medical Research Council and National Institute for Health Research funded the National Phenome Centre to deliver broad access to a world-class capability in metabolic phenotyping for biomarker discovery and validation, improved patient stratification, and early identification of drug efficacy and safety.The Lancet 05/2015; DOI:10.1016/S0140-6736(15)60722-X · 45.22 Impact Factor
- Circulation Research 03/2015; 116(7):1109-1111. DOI:10.1161/CIRCRESAHA.115.305852 · 11.02 Impact Factor
Article: Salt Restriction Leads to Activation of Adult Renal Mesenchymal Stromal Cell-Like Cells via Prostaglandin E2 and E-Prostanoid Receptor 4[Show abstract] [Hide abstract]
ABSTRACT: Despite the importance of juxtaglomerular cell recruitment in the pathophysiology of cardiovascular diseases, the mechanisms that underlie renin production under conditions of chronic stimulation remain elusive. We have previously shown that CD44+ mesenchymal-like cells (CD44+ cells) exist in the adult kidney. Under chronic sodium deprivation, these cells are recruited to the juxtaglomerular area and differentiate to new renin-expressing cells. Given the proximity of macula densa to the juxtaglomerular area and the importance of macula densa released prostanoids in renin synthesis and release, we hypothesized that chronic sodium deprivation induces macula densa release of prostanoids, stimulating renal CD44+ cell activation and differentiation. CD44+ cells were isolated from adult kidneys and cocultured with the macula densa cell line, MMDD1, in normal or low-sodium medium. Low sodium stimulated prostaglandin E2 production by MMDD1 and induced migration of CD44+ cells. These effects were inhibited by addition of a cyclooxygenase 2 inhibitor (NS398) or an E-prostanoid receptor 4 antagonist (AH23848) to MMDD1 or CD44+ cells, respectively. Addition of prostaglandin E2 to CD44+ cells increased cell migration and induced renin expression. In vivo activation of renal CD44+ cells during juxtaglomerular recruitment was attenuated in wild-type mice subjected to salt restriction in the presence of cyclooxygenase 2 inhibitor rofecoxib. Similar results were observed in E-prostanoid receptor 4 knockout mice subjected to salt restriction. These results show that the prostaglandin E2/E-prostanoid receptor 4 pathway plays a key role in the activation of renal CD44+ mesenchymal stromal cell-like cells during conditions of juxtaglomerular recruitment; highlighting the importance of this pathway as a key regulatory mechanism of juxtaglomerular recruitment. © 2015 American Heart Association, Inc.Hypertension 03/2015; 65(5). DOI:10.1161/HYPERTENSIONAHA.114.04611 · 6.48 Impact Factor
- JAMA The Journal of the American Medical Association 01/2015; 313(2):143-4. DOI:10.1001/jama.2014.17660 · 35.29 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Since its discovery, 25 years ago, the angiotensin AT2 receptor (AT2R) has puzzled the scientific community because of its distinct -localization, regulation, signaling pathways, and biological effects separating it clearly from the classical features of the renin-angiotensin system (RAS) mediated by the angiotensin AT1 receptor. Intensive research over the years has revealed major characteristics of the AT2R as a modulatory player involved in antiproliferation, anti-inflammation, natriuresis, neuroregeneration, and apoptosis, that is, -biological programs that can counterbalance pathological processes and enable recovery from disease. The AT2R has thus mutated from an "-enigmatic" receptor to a significant member of the "protective arm" of the RAS. The recent development of novel, small molecule- and peptide-derived AT2R agonists offers a therapeutic potential in humans with a variety of clinical indications.
Article: MicroRNA Induced Cardiac Reprogramming In Vivo: Evidence for Mature Cardiac Myocytes and Improved Cardiac Function[Show abstract] [Hide abstract]
ABSTRACT: Rationale: A major goal for the treatment of heart tissue damaged by cardiac injury is to develop strategies for restoring healthy heart muscle through the regeneration and repair of damaged myocardium. We recently demonstrated that administration of a specific combination of microRNAs (miR combo) into the infarcted myocardium leads to direct in vivo reprogramming of noncardiac myocytes to cardiac myocytes. However, the biological and functional consequences of such reprogramming are not yet known. Objective: The aim of this study was to determine whether noncardiac myocytes directly reprogrammed using miRNAs in vivo develop into mature functional cardiac myocytes in situ, and whether reprogramming leads to improvement of cardiac function. Methods and results: We subjected fibroblast-specific protein 1-Cre mice/tandem dimer Tomato (tdTomato) mice to cardiac injury by permanent ligation of the left anterior descending coronary artery and injected lentiviruses encoding miR combo or a control nontargeting miRNA. miR combo significantly increased the number of reprogramming events in vivo. Five to 6 weeks after injury, morphological and physiological properties of tdTomato(-) and tdTomato(+) cardiac myocyte-like cells were analyzed ex vivo. tdTomato(+) cells expressed cardiac myocyte markers, sarcomeric organization, excitation-contraction coupling, and action potentials characteristic of mature ventricular cardiac myocytes (tdTomato(-) cells). Reprogramming was associated with improvement of cardiac function, as analyzed by serial echocardiography. There was a time delayed and progressive improvement in fractional shortening and other measures of ventricular function, indicating that miR combo promotes functional recovery of damaged myocardium. Conclusions: The findings from this study further validate the potential use of miRNA-mediated reprogramming as a therapeutic approach to promote cardiac regeneration after myocardial injury.Circulation Research 10/2014; 116(3). DOI:10.1161/CIRCRESAHA.116.304510 · 11.02 Impact Factor
- JAMA The Journal of the American Medical Association 10/2014; 312(15):1507-1508. DOI:10.1001/jama.2014.12986 · 35.29 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Rationale: Cardiac progenitor cells (CPCs) are thought to differentiate into the major cell types of the heart: cardiomyocytes, smooth muscle cells, and endothelial cells. We have recently identified ABI family, member 3 (NESH) binding protein (Abi3bp) as a protein important for mesenchymal stem cell biology. Because CPCs share several characteristics with mesenchymal stem cells, we hypothesized that Abi3bp would similarly affect CPC differentiation and proliferation. Objective: To determine whether Abi3bp regulates CPC proliferation and differentiation. Methods and results: In vivo, genetic ablation of the Abi3bp gene inhibited CPC differentiation, whereas CPC number and proliferative capacity were increased. This correlated with adverse recovery after myocardial infarction. In vitro, CPCs, either isolated from Abi3bp knockout mice or expressing an Abi3bp shRNA construct, displayed a higher proliferative capacity and, under differentiating conditions, reduced expression of both early and late cardiomyocyte markers. Abi3bp controlled CPC differentiation via integrin-β1, protein kinase C-ζ, and v-akt murine thymoma viral oncogene homolog. Conclusions: We have identified Abi3bp as a protein important for CPC differentiation and proliferation.Circulation Research 10/2014; 115(12). DOI:10.1161/CIRCRESAHA.115.304216 · 11.02 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The therapeutic administration of microRNAs represents an innovative reprogramming strategy with which to advance cardiac regeneration and personalized medicine. Recently, a distinct set of microRNAs was found capable of converting murine fibroblasts to cardiomyocyte-like cells in vitro. Further treatment with JAK inhibitor I significantly enhanced the efficiency of the microRNA-mediated reprogramming (Jayawardena et al., Circ Res 110(11):1465-1473, 2012). This novel technique serves as an initial tool for switching the cell fate of cardiac fibroblasts toward the cardiomyocyte lineage using microRNAs. As the budding field of reprogramming biology develops, we hope that a thorough examination of the chemical, physical, and temporal parameters determining reprogramming efficiency and maturation will enable a better understanding of the mechanisms governing cardiac cell fate and provide new approaches for drug discovery and therapy for cardiovascular diseases.Methods in molecular biology (Clifton, N.J.) 04/2014; 1150:263-72. DOI:10.1007/978-1-4939-0512-6_18 · 1.29 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Despite advances in the treatment of acute tissue ischemia significant challenges remain in effective cytoprotection from ischemic cell death. It has been documented that injected stem cells, such as mesenchymal stem cells (MSCs), can confer protection to ischemic tissue through the release of paracrine factors. The study of these factors is essential for understanding tissue repair and the development of new therapeutic approaches for regenerative medicine. We have recently shown that a novel factor secreted by MSCs, which we called HASF (Hypoxia and Akt induced Stem cell Factor), promotes cardiomyocyte proliferation. In this study we show that HASF has a cytoprotective effect on ischemia induced cardiomyocyte death. We assessed whether HASF could potentially be used as a therapeutic agent to prevent the damage associated with myocardial infarction. In vitro treatment of cardiomyocytes with HASF protein resulted in decreased apoptosis; TUNEL positive nuclei were fewer in number, and caspase activation and mitochondrial pore opening were inhibited. Purified HASF protein was injected into the heart immediately following myocardial infarction. Heart function was found to be comparable to sham operated animals one month following injury and fibrosis was significantly reduced. In vivo and in vitro HASF activated protein kinase C ε (PKCε). Inhibition of PKCε blocked the HASF effect on apoptosis. Furthermore, the beneficial effects of HASF were lost in mice lacking PKCε. Collectively these results identify HASF as a protein of significant therapeutic potential, acting in part through PKCε.Journal of Molecular and Cellular Cardiology 11/2013; 66. DOI:10.1016/j.yjmcc.2013.11.010 · 4.66 Impact Factor
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ABSTRACT: With a changing health care landscape and a growing gap between the excess costs of fulfilling academic health centers' missions and the available funding, the integrity of those missions is in jeopardy. Profound changes are needed in AHCs' organization and operations. Academic health centers (AHCs) have long led the advancement of science and medicine by pursuing missions of clinical care, research, and education. AHCs have been places where important fundamental and translational research is performed and medical innovations are created and tested. Given the dramatic changes ahead in health care and deteriorating research funding, can this record of achievement continue, or do AHCs in the United States face a growing risk of extinction?(1) Despite their substantial societal value, these centers have an uncertain future. The health care landscape is changing rapidly owing to the Affordable Care Act, state budget deficits, and ...New England Journal of Medicine 09/2013; 369(11):991-3. DOI:10.1056/NEJMp1302374 · 55.87 Impact Factor
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ABSTRACT: There is a real need for innovation in health care delivery, as well as in medicine, to address related challenges of access, quality, and affordability through new and creative approaches. Health care environments must foster innovation, not just allowing it but actively encouraging it to happen anywhere and at every level in health care and medicine-from the laboratory, to the operating room, bedside, and clinics. This paper reviews the essential elements and environmental factors important for health-related innovation to flourish in academic health systems.The authors maintain that innovation must be actively cultivated by teaching it, creating "space" for and supporting it, and providing opportunities for its implementation. The authors seek to show the importance of these three fundamental principles and how they can be implemented, highlighting examples from across the country and their own institution.Health innovation cannot be relegated to a second-class status by the urgency of day-to-day operations, patient care, and the requirements of traditional research. Innovation needs to be elevated to a committed endeavor and become a part of an organization's culture, particularly in academic health centers.Academic medicine: journal of the Association of American Medical Colleges 08/2013; 88(10). DOI:10.1097/ACM.0b013e3182a32fc2 · 2.93 Impact Factor
Article: Abi3bp Is a Multifunctional Autocrine/Paracrine Factor that Regulates Mesenchymal Stem Cell Biology[Show abstract] [Hide abstract]
ABSTRACT: Mesenchymal stem cells (MSCs) transplanted into injured myocardium promote repair through paracrine mechanisms. We have previously shown that MSCs overexpressing AKT1 (Akt-MSCs) exhibit enhanced properties for cardiac repair. In this study, we investigated the relevance of Abi3bp towards MSC biology. Abi3bp formed extracellular deposits with expression controlled by Akt1 and ubiquitin-mediated degradation. Abi3bp knockdown/knockout stabilized focal adhesions and promoted stress-fiber formation. Furthermore, MSCs from Abi3bp knockout mice displayed severe deficiencies in osteogenic and adipogenic differentiation. Knockout or stable knockdown of Abi3bp increased MSC and Akt-MSC proliferation, promoting S-phase entry via cyclin-d1, ERK1/2 and Src. Upon Abi3bp binding to integrin-β1 Src associated with paxillin which inhibited proliferation. In vivo, Abi3bp knockout increased MSC number and proliferation in bone marrow, lung, and liver. In summary, we have identified a novel extracellular matrix protein necessary for the switch from proliferation to differentiation in MSCs.Stem Cells 08/2013; 31(8). DOI:10.1002/stem.1416 · 6.52 Impact Factor
Article: C3orf58, a Novel Paracrine Protein, Stimulates Cardiomyocyte Cell-Cycle Progression Through the PI3K-AKT-CDK7 Pathway[Show abstract] [Hide abstract]
ABSTRACT: Rationale: The regenerative capacity of the heart is markedly diminished shortly after birth, coinciding with overall withdrawal of cardiomyocytes from cell cycle. Consequently, the adult mammalian heart has limited capacity to regenerate after injury. The discovery of factors that can induce cardiomyocyte proliferation is, therefore, of high interest and has been the focus of extensive investigation throughout the past years. Objective: We have recently identified C3orf58 as a novel hypoxia and Akt induced stem cell factor (HASF) secreted from mesenchymal stem cells, which can promote cardiac repair through cytoprotective mechanisms. Here, we tested the hypothesis that HASF can also contribute to cardiac regeneration by stimulating cardiomyocyte division and proliferation. Methods and results: Neonatal ventricular cardiomyocytes were stimulated in culture for 7 days with purified recombinant HASF protein. Compared with control untreated cells, HASF-treated neonatal cardiomyocytes exhibited 60% increase in DNA synthesis as measured by bromodeoxyuridine incorporation. These results were confirmed by immunofluorescence confocal microscopy showing a 50% to 100% increase in the number of cardiomyocytes in the mitotic and cytokinesis phases. Importantly, in vivo cardiac overexpression of HASF in a transgenic mouse model resulted in enhanced level of DNA synthesis and cytokinesis in neonatal and adult cardiomyocytes. These proliferative effects were modulated by a phosphoinositide 3-kinase-protein kinase B-cycle-dependent kinase 7 pathway as revealed by the use of phosphoinositide 3-kinase -pathway-specific inhibitors and silencing of the Cdk7 gene. Conclusions: Our studies support the hypothesis that HASF induces cardiomyocyte proliferation via a phosphoinositide 3-kinase-protein kinase B-cycle-dependent kinase 7 pathway. The implications of this finding may be significant for cardiac regeneration biology and therapeutics.Circulation Research 06/2013; 113(4). DOI:10.1161/CIRCRESAHA.113.301075 · 11.02 Impact Factor
Article: Adult Renal Mesenchymal Stem Cell-Like Cells Contribute to Juxtaglomerular Cell Recruitment[Show abstract] [Hide abstract]
ABSTRACT: The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44(+) mesenchymal stem cell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44(+) MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.Journal of the American Society of Nephrology 06/2013; 24(8). DOI:10.1681/ASN.2012060596 · 9.34 Impact Factor
Conference Paper: Abstract 141: Histone Methyltransferase Setdb2 is important for miRNA mediated cardiac reprogramming[Show abstract] [Hide abstract]
ABSTRACT: Rationale: Regeneration of damaged cardiac tissue after injury presents a daunting challenge in cardiovascular medicine. Recent developments in reprogramming of somatic cells directly to cells of other lineages have raised the possibility of using this approach for cardiac regenerative therapy. Our group recently demonstrated successful miRNA mediated cardiac reprogramming in vitro and in vivo using a combination of miRNAs 1, 133, 206 and 499. Although, the molecular mechanisms underlying miRNA mediated fibroblast reprogramming to cardiomyocytes are yet unknown, accumulating evidence suggest that reprogramming acts through distinct phases and that histone modifications play an important role in these processes. Objective: Identify key genes involved in initiating miRNA mediated reprogramming via histone modifications. Methods and Results: For this, we analyzed the expression levels of 81 different genes involved in chromatin modification 4 days after miRNA transfection using PCR arrays. This analysis revealed that 6 of the 81 tested genes showed differential gene expression (-1.5-fold and p <0.02). JAK inhibitor-1 treatment, known for increasing reprogramming efficiency, further enhanced gene expression changes in 5 of these 6 genes. Setdb2, an H3K9 methyltransferase, was one of the most down-regulated targets 4 days after miRNA transfection (-1.4 fold, p<0.001). This effect was enhanced further when miRNAs were combined with the JAK inhibitor-1 (-2.6 fold, p<0.001). Silencing of Setdb2 using siRNAs further accentuated miRNA cardiac reprogramming as measured by cardiac transcription factor expression at 3 days and 6 days post treatment. Similar trends were observed by FACS analysis detecting increased percentage of αMHC-positive cells in siRNA treated fibroblasts compared to control treated only with the miRNA combination. Interestingly, our data showed that Setdb2 silencing alone was sufficient to initiate cardiac reprogramming, suggesting that Setdb2 might play a crucial role in defining cardiac cell fate. Conclusion: In conclusion our results indicate that Setdb2 down-regulation plays an important role in the direct reprogramming of fibroblasts to cardiomyocyte-like cells.BCVS 2013, Las Vegas, NV; 05/2013
Top Journals
Washington DC VA Medical CenterWashington, Washington, D.C., United States
The Washington InstituteWashington, Washington, D.C., United States
Duke University
Durham, North Carolina, United States
- Department of Medicine
Duke University Medical Center
Durham, North Carolina, United States
- • Department of Medicine
- • Division of Cardiology
Harvard UniversityCambridge, Massachusetts, United States
Harvard Medical School
Boston, MA, United States
- Department of Medicine
Brigham and Women's Hospital
Boston, Massachusetts, United States
- • Department of Medicine
- • Division of Cardiovascular Medicine
University of Glasgow
Glasgow, Scotland, United Kingdom
- Institute of Cardiovascular and Medical Sciences
Queen's University
Kingston, Ontario, Canada
- Department of Physiology
Morehouse School of MedicineAtlanta, Georgia, United States
University of California, San Francisco
San Francisco, CA, United States
- Division of Adult Cardiothoracic Surgery
University of KuopioKuopio, Northern Savo, Finland
University of Toronto
Toronto, Ontario, Canada
- Department of Laboratory Medicine and Pathobiology
Justus-Liebig-Universität GießenGieben, Hesse, Germany
Stanford University
Stanford, California, United States
- • Division of Cardiovascular Medicine
- • Falk Cardiovascular Research Center
Joslin Diabetes CenterBoston, Massachusetts, United States
Universität Heidelberg
Heidelburg, Baden-Württemberg, Germany
- Department of Clinical Pharmacology
Stanford Medicine
Stanford, California, United States
- • Falk Cardiovascular Research Center
- • Division of Cardiovascular Medicine
Osaka UniversitySuika, Ōsaka, Japan
Case Western Reserve UniversityCleveland, Ohio, United States
Osaka City University
Ōsaka, Ōsaka, Japan
- Graduate School of Medicine
University of FloridaGainesville, Florida, United States
National Institute for Biological Standards and ControlPotters Bar, England, United Kingdom
University of Massachusetts BostonBoston, Massachusetts, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
- Department of Medicine


text:
Hotel Sinar Bali
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TripAdvisor Reviews Hotel Sinar Bali Legian
Travel Blogs from Legian
Lovely Legian
... were acquired, even bedding was purchased!! Then it was on to Posers for dinner...an amazing mix of Nasi Goreng, Beef Rendang, more spring rolls, and more satay...and of course, more Bintang!! This was quickly followed by a massage at Amelie Spa. I got ear candling and a truly spectacular head massage which left me with just-been-bedded hair and a stoned brain, which I took back to the hotel for a nice shower and bed.
Kawaiizy fun in the land of the rising Sun.
... with such beautiful and wonderous exhibits that it is impossible not to be moved and inspired by it all. I won't go into details of all the amazing things housed within, but I will say there is a giant Cat Bus for toddlers to play in and that I am still disappointed that adults are not allowed to partake in that joy. Tokyo slipped by in nine frenetic days. We visited parks and temples (the lucky cat temple was strange and interesting), had complete communication ...
Surf, Sand, and Sun
... selling comfy chairs, surf boards and cold beers. Being low season, it didn't take us long to find a new friend named Bego. We negotiated an acceptable rate for 2 boards, a one hour lesson for Julie, and some umbrella space for staying out of the sun.
Julie kicked some ass, and actually was up on her feet on her first run. A remarkable feat I say! I floundered around on my own, and after a couple hard crashes into the sand on ...
Mount batur
... and we took lots of breaks until we finally hit the top where there is a place to get snacks and drinks from including hot tea and coffee :-) ($2.5) From here you go downhill a little and to a viewing area with benches and this is where our group stayed to watch as the sky got lighter and lighter. The bigger mountain mount Agung was in front of us and the sun came up over the top of this volcano at around 6 and it really was spectacular. Just as I ...
Aug 3-4 Mt. Agung
... meters (8000 ft) - about 2 and a quarter hours further, we stopped again. There was no letup in difficulty. We ate Snickers, and turned around. All of south Bali could be seen, small lights dotting the landscape. The stars, the incredible stars were beyond beauty. Constellations could be easily seen, along with hints of milkiness from the galaxy. It was a much needed rest, and uplifting of the mood. We headed off again. Soon, particles of dust ...


text:
The process of buying a new BMW car or truck can seem overwhelming if you don't know where to begin. Edmunds.com can get you started on the right track with a convenient directory of BMW car dealerships in and around Overton, Nevada. Compare online price quotes on the new or used car, truck, SUV, minivan, or wagon of your choice to locate the best deals. Edmunds.com makes it easy to find trusted BMW car dealers in Overton, saving car buyers time and money on what will be an important purchase.
Non Display Review Name "I recently purchased a new 2014 320i from BMW of Henderson. I can honestly say I couldn't be more satisfied with whole purchase process. From my initi"... Read more Review by: js919


text:
Seeing the 7-inch tablet market suffering from fierce price competition, several vendors are turning to focus on 8-inch and above segments to avoid profit drops
Last update: Tuesday 18 March 2014 [7 news items]
Digitimes Research: Google shifts focus to large-size tablet competition
Mar 18, 15:49
Digitimes Research has learned that Google is set to release at least two Nexus tablets in 2014 with an 8.9-inch model already under development and set to enter mass production in...
Digitimes Research: 12-inch tablets facing development hurdles
Mar 14, 15:01
Brand vendors have started showing interests in large-size tablets since early 2014. In addition to Apple's rumored 12.85-inch tablet, Samsung Electronics has already launched a 12.2-inch...
Tablet sales in the 7- to 8-inch segment expected to drop nearly 15% in 2014
Feb 18, 14:52
About 56% of tablet vendors' sales are expected to come from 7- to 8-inch units in 2014, down from about 70% in 2013, due to increased competition from large-size smartphones and...
CES 2014: Samsung unveils 12-inch tablet lineups
Jan 9, 14:02
Samsung Electronics has unveiled the Galaxy NotePRO and TabPRO line of tablets: the Galaxy NotePRO (12.2-inch), TabPRO (12.2-, 10.1-, 8.4-inch) at the CES 2014.
Digitimes Research: Korea tablet market being impacted by phablet products
Jan 3, 15:04
South Korea's tablet shipments have been dropping after reaching a peak in 2011 due to the rapid appearance of large-size smartphones and phablets, which are gradually replacing consumer...
Apple large-size tablet rumored for launch in October 2014
Dec 23, 15:45
Apple is rumored to release a 12.9-inch tablet in October 2014, targeting North America's educational market, according to sources from the upstream supply chain.
Tablet brand vendors preparing for competition in September
Aug 12, 21:11
First-tier tablet vendors including Apple, Samsung Electronics and Amazon, have all geared up for the next-generation tablet competition in September, while Intel and Google are also...
China Mobile completes installation of 1 million TD-LTE base stations around China
Before Going to Press | 1min ago
China market: TSMC seeing brisk demand for 16nm chips
Before Going to Press | 5min ago
Foxconn ties up with OnePlus to produce smartphones in India
Before Going to Press | 6min ago
Hong Kong Electronics Fair 2015 opens
Before Going to Press | 7min ago
Court dismisses legal action filed by ASE against SPIL
Before Going to Press | 12min ago
LED lighting demand in Southeast Asia market in 2015 estimated at US$1.5 billion
Before Going to Press | 14min ago
Samsung to use Clear Force touch technology in Galaxy S7 handset, says report
Before Going to Press | 15min ago
Taiwan has advantage in flexible electronics industry, says ITRI
Before Going to Press | 20min ago
HTC launches 6 smartphones in Bangladesh
Before Going to Press | 21min ago
Wah Hong expects 10% on-quarter revenue increase in 3Q15
Before Going to Press | 21min ago
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- Acer pushing new business operation to achieve growth
- Neo Solar Power offers PERC monocrystalline silicon solar cell Black 21
- Taiwan preparing for 2nd-round TPP talks
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13-Oct-2015 markets closed
|TSE electronic
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- Amazing 4K video shows how a weightless blob of water behaves in space (Oct 12) - Mashable
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- Analyzing Apple statement on TSMC and Samsung A9 SoCs (Oct 9) - Anandtech
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- HP's giant curved all-in-one is like computing on a mural (Oct 7) - Wired
- Digitimes Research: iPad Pro shipments to be less than 3 million units in 4Q15
- Digitimes Research: Intel processor shipments rely on Windows tablets for growth
- Digitimes Research: Tablets with phone functionality from white-box players to suffer over 15% decline in 2Q15
- Digitimes Research: Intel 28nm SoFIA 4G AP delayed to early 2016; may face overlap issue with 14nm version
- Digitimes Research: White-box players pushing 10.1-inch Windows tablets
Taiwan notebook Original Design Manufacturers (ODMs) account for more than 90% of global notebook production and Digitimes is there to provide daily...
The early success Google's Android platform has achieved in the handset market has caused system makers, software developers and semiconductor players...
Notebook industry seeing late RFQ for 2016 orders
Notebook brand vendors have been postponing their RFQ processores for 2016orders, lacking development direction and waiting for Intel new Skylake processors...
Apple has released its latest innovations including the iPhone 6s and 6s Plus, iPad Pro and new Apple TV.
Targeting niche markets: Q&A with ST Liu, president of Acer handset unit
Notebook vendor Acer aims to ship at least five million smartphones in 2015 and plans to hike the shipments...
Security a must for IoT market: Q&A with NXP EVP Steve Owen
The acquisition of Freescale by NXP Semiconductors will make NXP the world's second largest MCU supplier...
Gigabyte to stay competitive in VGA market with new technology: Q&A with Eddie Lin, associate vice president of Gaming Product Business Unit
Competition in the graphics card market has grown fierce as demand for graphics cards from the gaming...
Japan startup Socionext aiming big in IT industry
Socionext, a Japan-based corporation focused on the design, development, and sales of system-on-chip...
- Smartphone and tablet industry: The view from Taiwan - May 2012
Taiwan-based companies have a long and successful history of involvement in the supply chain for mobile devices, which for the purposes of this article consist...
- Taiwan motherboard industry overview - May 2012
The year 2011 saw the motherboard industry reverse its trend of declining shipments year-on-year, to post a slight 0.2% growth. This upturn in fortunes was expected...
- Notebook market overview - Jun 2011
The notebook industry in 2010 experienced several major events that significantly changed the industry's ecosystem for the year and the industry is also believed...
- Taiwan motherboard industry overview - Jun 2011
The motherboard industry began 2010 with optimism and expected to see a reversal of the previous two years' declines in revenues and shipments as the impact of...
- Wireless broadband developments in Southeast Asia markets
As of 2013, the 10 ASEAN nations had a total of over 700 million mobile subscriptions, with the CAGR from 2003-2013 reaching 24%. This Digitimes Research Special Report analyzes the various mobile broadband markets in ASEAN and looks at the respective trends in 4G LTE development for those markets.
- 2015 global tablet demand forecast
This Digitimes Research Special Report provides a 2015 forecast for the global tablet market and analyzes the strategies of key market players such as Google, Apple, Intel, and Microsoft.
- 2015 China smartphone panel trend forecast
This Digitimes Research Special Report analyzes the strategies of key China-based major panel makers BOE, Tianma and IVO for attacking the different market segments through technology and pricing, and their relationship to local vendors Huawei, Lenovo, ZTE, Xiaomi and Coolpad.


text:
...For any language, including ESL/ESOL, I avoid the direct method or any program that promises, like a get-thin-quick dieting commercial, unreliable progress in too short a time frame. Studies suggest, and my teaching method acknowledges, that language learning is a marathon?not a sprint. Contrar...
Boston, MAView Tutor
...Additionally, I have passed the Massachusetts Test for Educator Licensure (MTEL) in English as a Second Language. Also, I am certified in English and have taught Study Skills. Additionally, as a Masters prepared licensed and certified Occupational Therapist, I have worked with elementary school special needs students as well as taught Anatomy at the high school level.
Weymouth, MAView Tutor
...I am comfortable teaching swimming to any age. I am proficient at teaching techniques, and learning tips. I am proficient at strokes and breathing techniques.
Malden, MAView Tutor
...Patience is key with anything and I am committed to reaching our end goal!Having tutored over 20 elementary aged children in various subjects, from physical science and math to Spanish and English, I love doing it and continue to do so. Making it interactive and creative keeps their attention and allows them to eventually love learning that particular subject. They're sponges!
Somerville, MAView Tutor
Bonjour/Hola! My name is Lauren, and I am a language teacher with 10 years of experience. I have taught French and Spanish to grades PreK-9th as well as at the college level.
Topsfield, MAView Tutor


text:
Unless you are a circus enthusiast, the name Jomar probably doesn't mean anything to you. Even an experienced antique collector can rarely identify what it is. Mention Jomar to a circus history enthusiast, though, and he will immediately recognize the name of John Ringling's private railroad car. The name "Jomar" was created by combining the […]Read More
"Gee, these old postcards are cool—but I'm not really a collector," say several of my friends. Some tell me that they have a few old postcards that were sent to family members, and they just don't know what to do with them. Let's explore some ideas for interesting things can you do with postcards. Create […]Read More
The new Most Expensive Thing in the World is a stamp; the 1856 British Guiana One-Cent Magenta postage stamp, to be exact. The calculations going into the designation seem to make sense. The little red scrap of paper, measuring just one inch by 1 1.2 inches, sold on Tuesday night for $7.9 million. Add in […]Read More
Collecting baseball cards of your favorite rookie players has changed drastically over the last several years. Today, a player's first officially licensed trading card may be produced years before that particular player ever steps foot onto the diamond for an MLB team. This fact has created a niche in the hobby called prospecting: collecting early […]Read More
When published lots are abruptly taken off the auction block, there is usually controversy involved. That is certainly true of a recent cancellation that involved a trove of private letters written by Jacqueline Kennedy to a Catholic priest. Their friendship started in 1950, when she was still Jacqueline Bouvier—a 21-year-old socialite visiting Ireland with her […]Read More
Chinese Export Silver always adapted to the realities of Chinese history. It was, after all, a product of that history, as such, that it has qualities that no other silver category possesses. Viewed in the overall context of China, it is an excellent indicator of prevailing historical events at any given time. That a de-facto […]Read More
After talking with Eric Bradley—the author of the newly released book "Mantiques: A Manly Guide to Cool Stuff"—last week about mantiques and who collects them, I started thinking about who in popular culture had an affinity for the weird, manly stuff that fall in this collectibles category. I have only been able to come up […]Read More
The term "antiques" used to elicit images of silver tea sets and Edwardian sideboards and even that "priceless Ming vaaase." But if you say the word now, it's just as likely to bring to mind thoughts of rusty two-handed saws and old snow shoes and surf boards. While the former are "antiques," the latter are […]Read More
In true circus style, clowns, a ringmaster and music from a 120-year-old Bell Wagon—all provided by Ringling Bros. and Barnum & Bailey—accompanied the unveiling of a series of commemorative United States forever postage stamps earlier this month on the grounds of The John and Mable Ringling Museum of Art in Sarasota, Fla. This is the […]Read More
It's happened again! With a new X-men film opening in theaters everywhere this weekend, prices on X-Men back issues have gone completely and utterly insane. As several new characters join the X-Men's movie roster, comic fans have been devouring (not literally) key issues, such as: • Uncanny X-Men #317, the first appearance of Blink (selling […]Read More


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Foxconn H55MX-S (H55 Express) Micro-ATX Motherboard - Final Thoughts
Final Thoughts
The Foxconn H55MX-S is a hard one to call. On the one hand there are no tools to tweak the system. You are stuck with what you get. As you cannot dictate the amount of RAM you are allocating to the GPU, your graphical options are also limited. On the other hand, the board was able to perform normal computing tasks very easily.
This leads to a situation where we have to look at the usage model to determine if the Foxconn H55MX-S is worth the time and effort. At $80 from NewEgg.com it is certainly an inexpensive motherboard and one that fits into the usage model of entry level/business. In that category the Foxconn H55MX-S does very well.
You are not going to game with it and you certainly are not going to do any rendering (which leaves out some photo editing abilities like rendering frames etc.), but if what you are looking for is an inexpensive motherboard for simple computing (Internet, email, Office etc) then this is a good choice. If you are looking for higher-level tasks, you should look elsewhere.
PRICING: You can find products similar to this one for sale below.
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Whats On?
Yoga Nidra for deep rest with Jessica
On Oct 16th Jessica will be hosting the next instalment of the Yoga Nidra workshops.
Yoga Nidra is a very deep relaxation practice: relieves pain, fatigue, stress, insomnia & boosts energy… promotes positive mental health and wellbeing; so powerful they treat soldiers with PTSD with it. £25.
For more info or to book click here
Kids Yoga Workshops
Half Term Ages 4-8 years
with Sonia Patten (experienced yoga teacher)
Tues 27th & Weds 28th Oct 11:15 – 12:45
Kids Yoga workshops are a playful learning experience where children gain tools for a healthy body and happy mind. This 1.5-hour workshop is a "special" & also to see if there's demand for regular kids yoga. Includes fun partner work, breathing techniques to promote relaxation & good sleep, yoga games, led relaxation, stories & music. Kids Yoga develops strong, healthy bodies; cultivates confidence & self-esteem; enhances concentration & attention; improves co-ordination and sets the foundation for a healthy balanced life.
Investment: £15 per child
Limited Spaces available
Gemma Collins and her Designer Vagina: Jess' First Blog
I walked past the newsagents this week.
I don't usually look but the front page jumped out at me: "TOWIE's Gemma Collins: "I'm saving my designer vagina for Mr Right"!
Underneath that was a photo of Chantelle – whoever she is – in a bikini – apparently she's "overweight and (heaven forbid, lock up your daughters!) has CELLULITE".
Next to that was Cheryl Cole's diet secrets; then Jordan's fruit-shake weight loss… and it went on… and on… this was just the front page.
Our Studio
We are currently located within L A Fitness Health Club in Brentwood (but operating independently of the Club).
We currently specialise in smaller classes for up to 16 people.
The studio is a short walk from Brentwood rail station and there is plenty of on-site car parking available.
Our address is:
Chindits Lane, Warley, Brentwood CM14 5LF
Some of our classes are held at:
- Bluebell Hill Farm, Wigley Bush Lane, South Weald, Brentwood CM14 5QN
- St Peters Church, Wigley Bush Lane South Weald Brentwood CM145QN
- Becket Keys School, Sawyers Hall Ln, Brentwood, Essex CM15 9DA