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|By Marketwired .
Article Rating:
|June 11, 2014 11:00 PM EDT
SUNNYVALE, CA and JOHNSTOWN, CO -- (Marketwired) -- 06/11/14 -- Spinal Kinetics, the designer and manufacturer of the M6® Artificial Disc, and Kenneth A. Pettine, MD, a leading spine surgeon in northern Colorado, announced completion of the initial series of M6-C implants as part of a US FDA Clinical Trial at Arête Surgical Center in Johnstown, Colorado. To date, four patients have received the innovative artificial disc at Arête and are among the first treated nationwide.
Dr. Pettine is the only surgeon in Colorado enrolling for the FDA trial and one of only a select number of centers in the US. The trial compares single-level cervical disc replacement to single-level cervical fusion. The M6-C artificial disc represents next generation technology in artificial cervical disc design. "We are very excited to participate in this important clinical trial," said Dr. Kenneth Pettine, M6-C Clinical Trial Investigator and co-Founder of Arête Surgical Center and The Spine Institute at Rocky Mountain Associates in Orthopedic Medicine (Johnstown, CO). "The M6-C has established a phenomenal track record overseas, and we are happy to finally bring this advancement to our patient base here in the US for this clinical study."
The M6-C artificial cervical disc is designed to help patients suffering from degenerative disc disease of the spine, a common cause of chronic neck and arm pain. The M6 technology provides an alternative to spinal fusion and is designed to restore natural physiologic motion to the spine. The M6 is the only artificial disc that replicates the anatomic structure and biomechanics of a natural disc by incorporating both an artificial nucleus and annulus.
"Spinal Kinetics is proud to collaborate with Dr. Kenneth Pettine at the Spine Institute and the team at Arête Surgical Center on this important milestone event," said Tom Afzal, President and CEO of Spinal Kinetics, Inc. "Spine surgeons and patients across the US have asked for access to this leading edge disc technology, and we are excited to start the process toward FDA approval by working with key Surgeon/Investigators like Dr. Pettine and innovative Spine Centers like Arête."
Introduced internationally in 2006, M6 technology has quickly become the market leader in Europe and other international markets and is available in over 27 countries worldwide. With approximately 30,000 implants to date, the M6 has become the disc of choice among leading spine surgeons around the world. In the U.S., Spinal Kinetics has successfully completed an FDA approved pilot study of the M6-C and subsequently received approval from the FDA to initiate the current clinical trial.
For more information on potential enrollment in the M6-C Clinical Trial, please contact Kira Sniff at [email protected], or (970) 669-8881 ext 229.
About Degenerative Disc Disease
Between adjacent vertebra throughout the spine is an intervertebral disc; a shock-absorbing pillow that helps maintain proper spacing, stability, and motion within the spine. Each disc has a fibrous outer band called the annulus fibrosus that encases a central, gel-like substance called the nucleus pulposus. The nucleus and annulus work together to absorb shock, help stabilize the spine, and provide a controlled range of motion between adjacent vertebra. Often brought on by aging, the spine begins to show signs of wear and tear and the discs can dry out and shrink. This degenerative process can put pressure on the spinal cord and nerves and may cause neck, arm and back pain and other painful conditions such as spinal stenosis or a herniated disc.
About Spinal Kinetics
Founded in 2003, Spinal Kinetics is a privately held medical device company focused on developing innovative and practical solutions for treatment of diseases of the spine. The M6-C cervical and M6-L lumbar artificial discs have rapidly established themselves among the leading artificial discs available due to their unique biomechanical properties that replicate the motion of a natural disc. The company is located in Sunnyvale, California.
About Kenneth A. Pettine, MD
Dr. Kenneth Pettine co-founded The Spine Institute at Rocky Mountain Associates in Orthopedic Medicine. He has an extensive background in spinal surgery, research, and rehabilitation. Dr. Pettine is a board certified fellowship trained spine surgeon. He is the recipient of numerous honors, a distinguished speaker at national and international symposiums, and the author of nearly 20 research publications. He has been the principal investigator for 16 FDA studies involving non-fusion implants, biologics, and stem cells. For information on Dr. Pettine and The Spine Institute visit www.spinerevolution.com
About Arête Surgical Center
Arête is a pain management and orthopedic/ spine ambulatory surgical facility in Johnstown, CO, that is licensed and joint commission accredited. We provide our patients with quality outpatient and inpatient surgical care in a safe and friendly environment. For information on the Arête Surgical Center, please visit www.aretesurgicalcenter.com
For more information on Spinal Kinetics, the M6 Artificial Disc and the M6-C Clinical Trial, please visit www.spinalkinetics.com.
For Spinal Kinetics Investor Relations, contact:
Gary Paul
Email Contact
SYS-CON Events announced today that Luxoft Holding, Inc., a leading provider of software development services and innovative IT solutions, has been named "Bronze Sponsor" of SYS-CON's @ThingsExpo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Luxoft's software development services consist of core and mission-critical custom software development and support, product engineering and testing, and technology consulting.
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The APN DevOps Competency highlights APN Partners who demonstrate deep capabilities delivering continuous integration, continuous delivery, and configuration management. They help customers transform their business to be more efficient and agile by leveraging the AWS platform and DevOps principles.
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SYS-CON Events announced today that Machkey International Company will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Machkey provides advanced connectivity solutions for just about everyone. Businesses or individuals, Machkey is dedicated to provide high-quality and cost-effective products to meet all your needs.
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WebRTC is about the data channel as much as about video and audio conferencing. However, basically all commercial WebRTC applications have been built with a focus on audio and video. The handling of "data" has been limited to text chat and file download – all other data sharing seems to end with screensharing. What is holding back a more intensive use of peer-to-peer data? In her session at @ThingsExpo, Dr Silvia Pfeiffer, WebRTC Applications Team Lead at National ICT Australia, will look at di...
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Who are you? How do you introduce yourself? Do you use a name, or do you greet a friend by the last four digits of his social security number? Assuming you don't, why are we content to associate our identity with 10 random digits assigned by our phone company? Identity is an issue that affects everyone, but as individuals we don't spend a lot of time thinking about it. In his session at @ThingsExpo, Ben Klang, Founder & President of Mojo Lingo, will discuss the impact of technology on identity....
Oct. 7, 2015 08:30 AM EDT Reads: 421
As the world moves towards more DevOps and microservices, application deployment to the cloud ought to become a lot simpler. The microservices architecture, which is the basis of many new age distributed systems such as OpenStack, NetFlix and so on, is at the heart of Cloud Foundry - a complete developer-oriented Platform as a Service (PaaS) that is IaaS agnostic and supports vCloud, OpenStack and AWS. In his session at 17th Cloud Expo, Raghavan "Rags" Srinivas, an Architect/Developer Evangeli...
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Developing software for the Internet of Things (IoT) comes with its own set of challenges. Security, privacy, and unified standards are a few key issues. In addition, each IoT product is comprised of at least three separate application components: the software embedded in the device, the backend big-data service, and the mobile application for the end user's controls. Each component is developed by a different team, using different technologies and practices, and deployed to a different stack/...
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NHK, Japan Broadcasting will feature upcoming @ThingsExpo Silicon Valley in a special IoT documentary which will be filmed on the expo floor November 3 to 5, 2015 in Santa Clara. NHK is the sole public TV network in Japan equivalent to BBC in UK and the largest in Asia with many award winning science and technology programs. Japanese TV is producing a documentary about IoT and Smart technology covering @ThingsExpo Silicon Valley. The program will be aired during the highest viewership season of ...
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WebRTC has had a real tough three or four years, and so have those working with it. Only a few short years ago, the development world were excited about WebRTC and proclaiming how awesome it was. You might have played with the technology a couple of years ago, only to find the extra infrastructure requirements were painful to implement and poorly documented. This probably left a bitter taste in your mouth, especially when things went wrong.
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WebRTC converts the entire network into a ubiquitous communications cloud thereby connecting anytime, anywhere through any point. In his session at WebRTC Summit,, Mark Castleman, EIR at Bell Labs and Head of Future X Labs, will discuss how the transformational nature of communications is achieved through the democratizing force of WebRTC. WebRTC is doing for voice what HTML did for web content.
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In today's digital world, change is the one constant. Disruptive innovations like cloud, mobility, social media, and the Internet of Things have reshaped the market and set new standards in customer expectations. To remain competitive, businesses must tap the potential of emerging technologies and markets through the rapid release of new products and services. However, the rigid and siloed structures of traditional IT platforms and processes are slowing them down – resulting in lengthy delivery ...
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According to Forrester, public cloud platforms are evolving, blurring the lines between Software as a Service (SaaS), Infrastructure as a Service (IaaS), and Platform as a Service (PaaS) in order to satisfy the needs of enterprises and widen their appeal to developers. In The Forrester Wave™: Enterprise Public Cloud Platforms, Q4 2014, Forrester evaluates the 16 most significant Enterprise Public Cloud Platforms and details how each vendor fulfills the 19 evaluation criteria points.
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The broad selection of hardware, the rapid evolution of operating systems and the time-to-market for mobile apps has been so rapid that new challenges for developers and engineers arise every day. Security, testing, hosting, and other metrics have to be considered through the process. In his session at Big Data Expo, Walter Maguire, Chief Field Technologist, HP Big Data Group, at Hewlett-Packard, will discuss the challenges faced by developers and a composite Big Data applications builder, foc...
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Adorama services include an in-house photo lab, AdoramaPix; pro equipment rental at Adorama Rental Company; and the award-winning Adorama Learning Center, which offers free creative education in online channels such as the popular Adorama TV.View items...
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Rockbridge, New Castle Complete $6M Reno of Airport HGI
Monday June 16th, 2014 - 9:33AM
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PORTLAND, ME—New Castle Hotels & Resorts completed a $6 million, 36-room expansion and renovation of the Hilton Garden Inn Portland Airport here with a vine-cutting ceremony and community gardening event at the nearby Masonic Learning Center.
The hotel is owned by Rockbridge and is one of three Maine hotels owned by Rockbridge and managed by New Castle.
The Hilton Garden Inn "Project Grow" lobby redesign creates a garden party feel that is highlighted by cabana draperies, pendant lighting and lanterns in the atrium, extensive interior and exterior plantings, a garden cart of food and drinks, communal breakfast and bar tables, along with patio-style furnishings.
The Hilton Garden Inn Portland Jetport is adjacent to the international airport and offers a total of 124 new and renovated guestrooms, a heated indoor pool and hot tub, 800 sq. ft. of meeting space, a 24-hour business center and the brand's Garden Grille and bar, serving breakfast, cocktails and dinner daily. The hotel offers complimentary shuttle service to the airport and downtown Portland, as well as in-room WiFi.
Tags: New Castle Hotels and Resorts • Rockbridge • Portland • ME • Hilton Garden Inn Portland Airport • Hospitality • Guest Facing • Construction/Renovation • Ownership • Operational • Management Companies • Owners/Operators •
When Strategic Hotels & Resorts announced in August that it was exploring "strategic alternatives," so to speak, including an outright sale, it left many wondering who had the financial wherewithal to scoop up the luxury hotel company. Many speculated it might be a large private equity company or, perhaps, foreign investors but, in the end, it was, who else, but Blackstone Group LLC that agreed to acquire the Chicago-based REIT.
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Apricot Jam with Vanilla
- Active Time 5m
- Total Time 50m
Makes 4 1/4 cups (Serves 68)
The development of techniques for preserving food came about because of the widely differing climatic conditions throughout the year in Spain. Fruit preserves used as pie fillings are very common, particularly for special and symbolic occasions when the kind of fruit required is out of season. Apricots formed part of what the Spanish Jews called "Haman pouches," which were little triangular turnovers used as gifts on Purim. In Arte de Reposteria (1747), Juan de la Mata extols the virtues of apricots and suggests various ways of preparing and preserving them.
- 2 pounds ripe apricots
- 1 cup water
- 3 cups sugar
- 1/2 vanilla pod, split lengthwise
Wash the fruit and cut in half, removing the pits.
Make a syrup by slowly dissolving the sugar in the water over low heat. Add the vanilla and cook for 2 minutes. Add the fruit and cook over low heat for 45 minutes, stirring frequently.
Transfer to sterilized jars and seal immediately.
Serving Size = 1 tablespoon
Recipe reprinted by permission of Weldon Russell. All rights reserved.
RecID 1221
nutrition information per serving
45 calories; 0g total fat; 0mg cholesterol; 0mg sodium; 11g carbohydrates; 0g fiber; 0g protein
These nutrition facts are calculated according to the ingredients listed in this recipe. Any substitutions will change these facts. Although we strive for accuracy, please note that food manufacturers occasionally change their food formulas, which could affect the calculations as shown.
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Arabian Nights Hotel, Cairo
- Free continental breakfast, free WiFi, and free parking
Main amenities
- 30 guestrooms
- Rooftop terrace
- 24-hour room service
- Airport shuttle
- 24-hour front desk
- Coffee/tea in the lobby
- Air conditioning
- Daily housekeeping
- Front desk safe
- Laundry service
- Multilingual staff
- Tour/ticket assistance
What's around
- In Islamic Cairo
- Khan el-Khalili (1.1 mi / 1.8 km)
- Museum of Islamic Art (1.3 mi / 2.2 km)
- Sultan Hussan Mosque (1.7 mi / 2.7 km)
- Saladin Citadel (2.2 mi / 3.5 km)
- Egyptian Museum (2.6 mi / 4.2 km)
The staff is wonderful. Very helpful and nice. Made sure we did not get ripped of. Gave…
Overall, the hotel is hardly worth the amount paid to stay. Double the price and stay…
Enter dates to check prices
Hotel Info: 866-539-8117from $10
- Triple Room, Shared Bathroom
- Triple Room, Ensuite
- Double Room, Ensuite
- Twin Room, 2 Single Beds, Ensuite
- Twin Room, 2 Single Beds, Shared Bathroom
- Single Room, 1 Double Bed, Ensuite
- Single Room, Shared Bathroom
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 30 rooms
- This hotel is arranged over 4 floors
Required at check in
- Cash deposit required
- Government-issued photo ID required
- Minimum guest age is 18
- Minimum check-in age is 18
- Minimum Spring Break check-in age is 18
Travelling with others
- No cribs (infant beds)
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Airport shuttle (available 24 hours) *
- Free self parking
Other information
- Resort fee included
Nearby One Star Cairo hotels
In the hotel
- Free continental breakfast
- 24-hour room service
- Free reception
- Coffee/tea in the lobby
- 24-hour front desk
- Tours/ticket assistance
- Dry cleaning/laundry service
- Laundry facilities
- Number of buildings/towers - 1
- Safe-deposit box at front desk
- Rooftop terrace
- Television in lobby
In the room
- Air conditioning
- Minibar
- Shower only
- Satellite TV channels
- Free WiFi
- Phone
- Daily housekeeping
Top Cairo hotels
Recently reviewed hotels in Cairo
- Novotel Cairo AirportFrom
"Nice to stay at a great comfortable hotel"Sep 1, 2015
- Golden Park Hotel Cairo HeliopolisFrom
"Great value in a quiet neighborhood and close to the airport"Aug 31, 2015
- Guardian Guest HouseFrom
"The guest house was wonderful. The employees were very kind, helpful and went out of their way to make us feel comfortable. The view from the hotel is amazing especially at sunset…"Aug 28, 2015
- Four Seasons Hotel Cairo at First ResidenceFrom
"Was grate"Aug 22, 2015
Arabian Nights Hotel, Cairo's small print
Also known as
- Arabian Nights Cairo
- Arabian Nights Hotel
- Arabian Nights Hotel Cairo
- Hotel Arabian Nights
Only registered guests are allowed in the guestrooms.
This property does not have elevators.
For transfers, guests must contact the property before arrival at the number on the booking confirmation.
Mandatory fees
The charges below are included in the total price displayed:
- Resort fee
Optional extras
Weekly housekeeping is provided; fees apply for additional cleaning
Airport shuttle service is offered for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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- Senior Management
I worked at Accenture full-time (More than 10 years)
This was a great company to work for, for over 15 years! Great opportunities for advancement or even doing something completely different. Like any company it had it's problems, mainly other co workers, but you can't please everybody though the company sure tried, loved our paid lunches, the motivational ways to keep us happy and upbeat even if some were corny, it was all in making the day go by faster and better. Loved it there!
It's a huge company so you can get lost in the shuffle, I didn't agree with a lot of the outsourcing that certain parts of the company had to do for it's clients. Otherwise it was the typical 'work' woes.
Advice to Management
Keep motivating your employees in a GOOD way, be down to earth yet authorative, keep an open door policy and actually listen to your people instead of riding off of your title and getting big headed to the point where the people around you are miserable because you suck as a person and boss. Happy employees equals better production.


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Preconstructed Deck Release: Catherine
Par Eredan, le Wednesday 7 October 2015 - iTCG
New cards have been released on Eredan iTCG:
Catherine. (3 evolutions in all) On its last evolution: Rare. Noz'Dingard Envoys. Warrior. Mage. Marauder. Human. WitchBlade. Spirit 2. Attack 8/10. Defense 3. Health points 15. Your Witchblades have Attack +2/+0 and Defense +1 until the end of the game. When one of your Witchblades plays a One handed Sword or a Light Spell: Attack +1/+0 until the end of the turn. Turns 5 or less: Gain Chain Spell.
Fragmenting light. Common. Noz'Dingard Envoys. Item Other. WitchBlade. Duration 1 fight. As this card activates, plays a Light Spell from your Deck or your Hand. Noz: Sacrifice 2: The Attack of your opponents is divided in half (rounded down) until the end of the turn. Marauder: Chain Light Spell.
For Catherine's release, we prepared a preconstructed deck for you, after a conception of "Recliff", the Noz'Dingard Guild Leader.
This 29 card deck (with 5 Rares and 8 Uncommons), containing Catherine, is available in store for 999 Fee'z thanks to a 50% discount that will last until Sunday at 11:59 PM (CET).
After this, the preconstructed deck "Catherine", will be available for 1999 Fee'z in the "Deck" section of the store.
All cards of this preconstructed deck are playable in Standard format Tournaments.
Ice Coffin. Uncommon. Noz'Dingard Envoys. Water Spell. Mage. WitchBlade. Defense +1. Removes all Items attached to your character. All these Items are then reattached and activate immediately. Chain.
Lux Draconis. Common. Noz'Dingard Envoys. Light Spell. Mage. Duration 3 turns. As this card activates your opponent suffers 4 to 5 magic damage points, +1 for each of your character's Classes (+3 max), and this card is attached to him. If your opponent is Nehantist, he has Defense -2.
These cards are now available in the Newcomers Booster.
Enjoy the game!


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They ate the schoolmaster's brownies
More allegations of abuse by Jeffrey Barton, who pleads not guilty
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text: Our room had a lovely view of the ocean. When we first checked in we got a room on the end of the line of units and it smelled very musty and moldy, felt damp and we requested to move. We were moved right away and our service was quick and friendly. During the rest of our stay we slept... More


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Utah Utes basketball: Utes return to Huntsman Center, host Boise State Wednesday
SALT LAKE CITY — It's a big week for the rebuilding Utah Utes. After opening the season with a 5-2 record, things kick up a notch with a home game against Boise State (6-1) Wednesday and a trip to rival BYU (5-3) on Saturday.
"It's huge. It really looks like the conference season has started in terms of quality of play," Utah coach Larry Krystkowiak said, while noting that both the Broncos and Cougars have offenses of note. "We are going to have our hands full. We haven't seen this kind of firepower before."
Although the Utes currently lead the Pac-12 in scoring defense by holding the opposition to an average of 57.6 points per game, Krystkowiak expects this week's games to be a huge challenge.
And it starts with what Krystkowiak calls "an absolute machine" in Boise State. The Broncos' lone loss this season was a four-point decision at No. 15 Michigan State. Since then they've knocked off No. 11 Creighton (83-70) on the road. Krystkowiak credits Leon Rice for doing a great job coaching the Broncos. Derrick Marks and Anthony Drmic are the scoring leaders with 18.7 and 15.9 points, respectively.
Utah counters with double-digit scorers Jarred DuBois (15.7 ppg) and Jordan Loveridge (12.3 ppg).
"The Boise State game is big," DuBois said. "Not because it's Boise State but because it's our next game. Each game that we play is big for us."
Utah is just one win away from equaling last season's six victories. However, it's not the only measuring stick for progress in the program.
"While wins and losses are important, our guys are getting better. They're getting better in the classroom and they're getting better in the community," Krystkowiak said. "They're getting better as basketball players, and we're going to represent the program in grand fashion."
It's a work in progress, though, with a revamped roster in the midst of a schedule that has featured wins over Willamette, Idaho State, Central Michigan, Wright State and Texas State. Losses have come against Sacramento State and SMU.
Fans attending Wednesday's game will receive a patch in remembrance of former Utah coach Rick Majerus, who died Saturday at the age of 64. A commemorative video will be shown and a moment of silence held before tipoff. The Utes will wear red patches with Majerus' initials on their uniforms for the remainder of the season.
Later in the year, Utah officials will hang a replica of Majerus' famed white sweater from the arena rafters.
Boise State (6-1) will play Utah (5-2) on Wednesday at 6:30 p.m. in the Huntsman Center. (TV: Pac-12 Networks, Radio: ESPN, 700 AM)
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The revolution takes another hit; Tea Party candidate says bad words
How do you know when your state's politics are officially boring? When something like this counts as a MAJOR. SCANDAL.
News of the punch comment comes on the heels of a video posted online Tuesday showing LePage telling a crowd that, if elected, they can expect to see newspaper headlines declaring Governor LePage tells Obama to go to hell.Normally, I wouldn't post about local politics, but this seems to be scandalous enough to attract the attention of national media. Equally horrifying? This same candidate told a reporter to "stop the bullshit" when he was asked a question about his wife's taxes.
Sorry folks...the revolution was fun while it lasted, but all good things must come to an end.
Seriously, though, there's a reason LePage is getting hit on stuff like this. The Dems who have been running this state for years can't defend their record so they (along with a willing press) are playing up the 'temperament' argument and asking whether LePage is emotionally stable enough to be governor.
The only problem with this argument? The Dems and the press made it an issue during the last election, and it hasn't exactly worked out that well. Americans were assured that Barack Obama had a "first-class temperament." As it turns out, the president is a bit thin-skinned and unable to take criticism.
What the media doesn't seem to realize about this election year is that the political silly season is over. Voters aren't looking for someone who can play the part of elected official. They're looking for people who share their beliefs and who have the willingness to lead and limit the intrusion of government into our lives.
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|August 30, 2014 07:03 AM EDT
EAST HANOVER, N.J., Aug. 30, 2014 /PRNewswire/ -- Today at the European Society of Cardiology congress and published simultaneously in the New England Journal of Medicine, Novartis revealed that its investigational heart failure medicine, LCZ696, was superior to ACE-inhibitor enalapril on key endpoints in the largest heart failure study ever done.1,7 In PARADIGM-HF, patients with heart failure with reduced ejection fraction (HF-REF) who were given LCZ696 were more likely to be alive and less likely to have been hospitalized for sudden deterioration of their heart failure than those given ACE-inhibitor enalapril.1 Patients received LCZ696 or enalapril on top of current best treatment.7
To view the multimedia assets associated with this release, please click http://www.multivu.com/players/English/7282951-novartis-lcz696-reduced-risk-cardiovascular-death-hospitalization-heart-patients/
The magnitude of benefit with LCZ696 against enalapril in HF-REF patients was highly statistically significant and clinically important. In the study, the benefit of LCZ696 was seen early, was sustained and was consistent across subgroups. LCZ696:1
- reduced the risk of death from cardiovascular (CV) causes by 20% (p=0.00004)
- reduced heart failure hospitalizations by 21% (p=0.00004)
- reduced the risk of all-cause mortality by 16% (p=0.0005)
Overall there was a 20% risk reduction on the primary endpoint, a composite measure of CV death or heart failure hospitalization (p=0.0000002).1
"By demonstrating a very significant reduction in cardiovascular deaths while improving quality of life, Novartis' new heart failure medicine, LCZ696, represents one of the most important cardiology advances of the last decade," said David Epstein, Division Head, Novartis Pharmaceuticals. "We want to thank leading cardiologists from around the world for their collaboration with us and their determination in advancing this important new life saving therapy for heart failure patients."
LCZ696, a twice a day tablet being investigated for heart failure, has a unique mode of action which is thought to reduce the strain on the failing heart.7,8 It acts to enhance the protective neurohormonal systems of the heart (NP system) while simultaneously suppressing the harmful effects of the overactive RAAS (renin-angiotensin-aldosterone system).7,8 Currently available medicines for HF-REF work only to block the detrimental effects.9 Despite existing therapies, the mortality rate remains very high with up to 50% of patients dying within 5 years of a diagnosis of heart failure.3 Approximately half of patients with heart failure have HF-REF.10
Analysis of the safety data from PARADIGM-HF showed side effects were manageable in the study.1 Fewer patients on LCZ696 discontinued study medication for any adverse event compared to those on enalapril (10.7% vs. 12.3%, respectively; p=0.03). The LCZ696 group had more hypotension and non-serious angioedema but less renal impairment, hyperkalemia and cough than the enalapril group. The most common adverse events with LCZ696 (incidence ≥10%) compared to enalapril were elevated serum potassium of more than 5.5 mmol/liter (16.1% vs. 17.3%), symptomatic hypotension (14.0% vs. 9.2%) and cough (11.3% vs. 14.3%).1
Novartis plans to file the New Drug Application for review with the US FDA by the end of 2014.
About the PARADIGM-HF study
PARADIGM-HF is a randomized, double-blind, Phase III study evaluating the efficacy and safety profile of LCZ696 versus enalapril (a widely studied ACE-inhibitor) in 8,442 patients with HF-REF.7,11,12 The baseline characteristics showed the patients enrolled were typical HF-REF patients with NYHA Class II-IV heart failure.11 PARADIGM-HF was specifically designed to see if LCZ696 could decrease CV mortality by at least 15% vs. enalapril.7 Patients received LCZ696 or enalapril in addition to current best treatment regimen. The primary endpoint is a composite of time to first occurrence of either cardiovascular death or heart failure hospitalization, and the trial is the largest heart failure study ever done.7
Secondary endpoints are change in the clinical summary score for heart failure symptoms and physical limitations (as assessed by Kansas City Cardiomyopathy Questionnaire) at 8 months; time to all-cause mortality; time to new onset atrial fibrillation; and time to occurrence of renal dysfunction.7 PARADIGM-HF was initiated in December 2009, and in March 2014 the Data Monitoring Committee confirmed that patients given LCZ696 were significantly less likely to die from CV causes, and that the primary endpoint was met, leading to the trial being stopped early.13
About LCZ696 in heart failure
LCZ696 is an ARNI (Angiotensin Receptor Neprilysin Inhibitor) and has a unique mode of action which is thought to reduce the strain on the failing heart.7,8 It acts to enhance the protective neurohormonal systems of the heart (NP system) while simultaneously suppressing the effects of the overactive renin-angiotensin-aldosterone system (RAAS).7,8
Heart failure is a debilitating and potentially life-threatening disease in which the heart cannot pump enough blood around the body. Symptoms such as breathlessness, fatigue and fluid retention can appear slowly and worsen over time, significantly impacting quality of life.4
Heart failure presents a major and growing health-economic burden that currently exceeds $30 billion in the United States, which accounts for both direct and indirect costs.3
The foregoing release contains forward-looking statements that can be identified by words such as "being investigated," "thought," "plans," "growing," "mission," or similar terms, or by express or implied discussions regarding potential marketing approvals for LCZ696, or regarding potential future revenues from LCZ696. You should not place undue reliance on these statements. Such forward-looking statements are based on the current beliefs and expectations of management regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that LCZ696 will be approved for sale in any market, or submitted for approval in any additional markets, or at any particular time. Neither can there be any guarantee that LCZ696 will be submitted or approved for any additional indications or labeling in any market, or at any particular time. Nor can there be any guarantee that LCZ696 will be commercially successful in the future. In particular, management's expectations regarding LCZ696 could be affected by, among other things, the uncertainties inherent in research and development, including unexpected clinical trial results and additional analysis of existing clinical data; unexpected regulatory actions or delays or government regulation generally; the company's ability to obtain or maintain proprietary intellectual property protection; general economic and industry conditions; global trends toward health care cost containment, including ongoing pricing pressures; unexpected manufacturing issues, and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.
About Novartis
Novartis Pharmaceuticals Corporation researches, develops, manufactures and markets innovative medicines aimed at improving patients' lives. We offer a broad range of medicines for cancer, cardiovascular disease, endocrine disease, inflammatory disease, infectious disease, neurological disease, organ transplantation, psychiatric disease, respiratory disease and skin conditions. The company's mission is to improve people's lives by pioneering novel healthcare solutions.
Located in East Hanover, New Jersey, Novartis Pharmaceuticals Corporation is an affiliate of Novartis AG, which provides innovative healthcare solutions that address the evolving needs of patients and societies. Headquartered in Basel, Switzerland, Novartis offers a diversified portfolio to best meet these needs: innovative medicines, eye care, cost-saving generic pharmaceuticals, preventive vaccines, over-the-counter and animal health products. Novartis is the only global company with leading positions in these areas. In 2013, the Group achieved net sales of USD 57.9 billion, while R&D throughout the Group amounted to approximately USD 9.9 billion (USD 9.6 billion excluding impairment and amortization charges). Novartis Group companies employ approximately 135,000 full-time-equivalent associates and sell products in more than 150 countries around the world. For more information, please visit http://www.novartis.com.
Novartis is on Twitter. Sign up to follow @Novartis at http://twitter.com/novartis.
- McMurray JJV, Packer M, Desai AS, et al. Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure. N Engl J Med. 2014. doi: 10.1056/NEJMoa1409077.
- The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991;325:293–302.
- Go A, Mozaffarian D, Roger V, et al. Heart Disease and Stroke Statistics−−2014 Update: A Report From the American Heart Association. Circulation. 2014;4(129):e28-e292.
- Fauci A and Longo D. Disorders of the Heart. Harrison's 'Principles of Internal Medicine. 17th ed. 2008;4:1442-55.
- Junger J, Schellberg D, Kraemer S, et al. Health related quality of life in patients with congestive heart failure: comparison with other chronic diseases and relation to functional variables. Heart. 2002;87(3):235-241.
- Levy D, Kenchaiah S, Larson M, et al. Long-Term Trends In The Incidence Of And Survival With Heart Failure. N Engl J Med. 2002;347(18):1397-1402.
- McMurray JJ, Packer M, Desai AS, et al. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2013;15:1062-73. doi:10.1093/eurjhf/hft052.
- Langenickel TH and Dole WP. Angiotensin receptor-neprilysin inhibition with LCZ696: a novel approach for the treatment of heart failure. Drug Discovery Today: Therapeutic Strategies. 2012;9(4):e131-e139. doi: 10.1016/j.ddstr.2013.11.002.
- Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;128:e240-e327. doi: 10.1161/CIR.0b013e31829e8776.
- Vasan R, Larson M, Benjamin E, et al. Congestive Heart Failure in Subjects with Normal Versus Reduced Left Ventricle Ejection Fraction. J Am Coll Cardiol. 1999;33(7):1948-1955.
- McMurray JJ, Packer M, Desai AS, et al. Baseline characteristics and treatment of patients in Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2014;16:817-825.
- Clinicaltrials.gov. This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure (PARADIGM-HF). NCT01035255. http://clinicaltrials.gov/show/NCT01035255. Accessed August 2014.
- Novartis. PARADIGM-HF trial of Novartis' LCZ696 for chronic heart failure closes early based on strength of interim results. Novartis U.S. Newsroom. March 31, 2014. http://www.novartis.com/newsroom/media-releases/en/2014/1772754.shtml. Accessed July 2014.
Novartis Media Relations
Julie Masow
Michael Billings
Novartis Media Relations
Novartis Pharmaceuticals Corporation
+1 212 830 2465 (direct)
+1 862 778 8656 (direct)
+1 862 579 8456 (mobile)
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For Novartis multimedia content, please visit www.thenewsmarket.com/Novartis.
For questions about the site or required registration, please contact: [email protected].
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For almost two decades, businesses have discovered great opportunities to engage with customers and even expand revenue through digital systems, including web and mobile applications. Yet, even now, the conversation between the business and the technologists that deliver these systems is strained, in large part due to misaligned objectives. In his session at DevOps Summit, James Urquhart, Senior Vice President of Performance Analytics at SOASTA, Inc., will discuss how measuring user outcomes –...
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SYS-CON Events announced today that Dyn, the worldwide leader in Internet Performance, will exhibit at SYS-CON's 17th International Cloud Expo®, which will take place on November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Dyn is a cloud-based Internet Performance company. Dyn helps companies monitor, control, and optimize online infrastructure for an exceptional end-user experience. Through a world-class network and unrivaled, objective intelligence into Internet condit...
Oct. 13, 2015 04:00 PM EDT Reads: 730
SYS-CON Events announced today that Sandy Carter, IBM General Manager Cloud Ecosystem and Developers, and a Social Business Evangelist, will keynote at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA.
Oct. 13, 2015 03:15 PM EDT Reads: 260
Saviynt Inc. has announced the availability of the next release of Saviynt for AWS. The comprehensive security and compliance solution provides a Command-and-Control center to gain visibility into risks in AWS, enforce real-time protection of critical workloads as well as data and automate access life-cycle governance. The solution enables AWS customers to meet their compliance mandates such as ITAR, SOX, PCI, etc. by including an extensive risk and controls library to detect known threats and b...
Oct. 13, 2015 03:00 PM EDT Reads: 331


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Tennessee Titans Reach a Contract with Defensive Tackle Mike Martin
One of the biggest concerns this year without a doubt was going to be the defense for the Tennessee Titans. Now with work done in the draft, and the personalities of the draftees, the Titans are able to start making some offers. They made an offer last week on Cornerback Coty Sensabaugh. Today the Titans have agreed to terms with Defensive Tackle Mike Martin.
Though the specifics of the deal are not all fully released yet, the Titans making him an offer clearly states that he is going to be a member of the team and he will help with the progression of play throughout the season.
Martin has some big shoes to fill and I am hoping that he will be able to handle the stress of becoming a professional as much as they say that he can. He recorded 54 tackles and has great size for the position standing at 6-foot-10 and 306 pounds. He is going to be a massive piece of machinery for the Titans. In his career he has 172 tackles and 10 sacks. During the NFL Combine, back in February he had the third best vertical and tied for the best broad jump. He was second in bench press and everyone knows that his main job this year will be to bring the power and replace Cortland Finnegan.
The biggest thing that I am excited for is to see him at the pass rush. According to his stats at the Combine, he is going to be a great asset to the team in this way and it's going to be solid for Tennessee.
Greg Hardy Wrong to Make Strange Tom Brady Comment
Dallas Cowboys' Greg Hardy made quite a random comment about Tom Brady and his wife Gisele Bundchen. Read More
Broncos vs. Raiders NFL Week 5 Preview
Here is a preview and score prediction for the Denver Broncos' visit to the Oakland Raiders in Week 5 of the 2015 NFL season. Read More
NFL Picks, Predictions for Week 5
Need help with picks and predictions for Week 5 of the 2015 NFL season? Look no further. Read More
5 Bold Predictions For Bills vs. Titans In Week 5
The Tennessee Titans and the Buffalo Bills are going to be squaring off in Week 5 with the potential for some crazy happenings on tap. Read More
Seahawks vs. Bengals Week 5 Preview, Prediction
The Seattle Seahawks travel to Cincinnati to take on the Bengals in a Week 5 showdown. Here is all the information you will need going into the game on Sunday. Read More
5 Bold Predictions for Steelers vs. Chargers
Here are five bold predictions for when the Pittsburgh Steelers take on the San Diego Chargers on Monday Night Football in Week 5. Read More
Power Ranking Top 10 NFL MVP Candidates
These 10 NFL players are the most likely candidates to win the NFL's coveted MVP award as we head into Week 5 Read More
Grading the First Quarter of the Colts' Season
The start to the Indianapolis Colts' 2015 season has not gone according to plan. While the Colts have played their way into a 2-2 record, they have a lot of problems and injuries to be worried about. Read More


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piano sheet music
Partitura de Somewhere Over the rainbow / What a wonderful world para voz e u...
It was written by Michael Kunze (book and lyrics) and Sylvester Levay (music).
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Music Sheet for Man In The Mirror by Michael Jackson!
LIbro de las canciones más representativas del musical West Side Story de Leo...
The Hills are Alive!
Cats Sheet Music for piano and vocal. Written by Andrew Llody Webber.
piano, guitar and lyrics
my heart will go on
Hey There Delilah by the Plain White T's piano sheet music
This action might not be possible to undo. Are you sure you want to continue?


text:
Jay Evensen: Strategic strike on Iran would kill thousands
What You May Have Missed
Most Popular
Across Site
In Opinion
Most Commented
By Jay Evensen, Deseret News
Published: Thursday, Oct. 4 2012 12:00 a.m. MDT
When protests broke out in Iran this week over the devaluation of the nation's currency, Khosrow Semnani saw the possible start of a solution.
An excellent editorial. Thank you for publishing this.
Pray for peace and rational actions from world leaders. If Israel, our default proxy in the region, attacka Iran, expect Iran to mine the Persian Gulf. attack our Carrier Battle Groups, and US Military Bases in the region. Imagine terror More..
This is a very well written, well thought out editorial. I am always wary of those who think war is inevitable and that force is the only option.
DeseretNews.com encourages a civil dialogue among its readers. We welcome your thoughtful comments.
— About comments
Jay Evensen is an editorial writer and columnist for the Deseret News. He has been on the editorial board since 1994. Prior to that, he was a reporter for the Deseret News, the Las Vegas Review-Journal and United Press more ..


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Apple CEO Tim Cook: Discrimination Holds Everyone Back
Ellen Page 'Very Happy' Since Coming Out Gay
Hillary Clinton Backs LGBT Protections; Warns GOP Will Try To Undo Marriage Equality
Joe Biden: Americans Have Moved Past Homophobia
Pope Francis Met With Gay Couple In U.S.
Tyler Glenn Says Being Out Has Positively Affected His Life
A federal judge on Tuesday struck down
down Kentucky's ban on gay marriage, saying it was unconstitutional.
In his 19-page ruling, U.S. District
Judge John G. Heyburn II wrote: "[T]his Court holds that the
Commonwealth's exclusion of same-sex couples from civil marriage
violates the Equal Protection Clause [of the U.S. Constitution]."
"In America, even sincerely and
long-held religious beliefs do not trump the constitutional rights of
those who happen to have been out-voted," he added.
In February, Heyburn ordered the state
to recognize the out-of-state marriages of gay and lesbian couples.
Heyburn, who was appointed to the bench
by President George H. W. Bush in 1992, put his ruling on hold.
Evan Wolfson, founder and president of
Freedom to Marry, applauded the decision.
"Today a Republican-appointed federal
judge in Kentucky held – as have more than 20 other judges and as
did the U.S. Supreme Court last year – that discriminatory state
marriage bans are unconstitutional," Wolfson said in a statement.
"It is wrong for the government to deny same-sex couples the
freedom to marry the person they love; a freedom that is part of
every American's liberty and pursuit of happiness. Today's ruling in
Kentucky underscores that America – all of America – is ready for
the freedom to marry, and the Supreme Court should bring the country
to national resolution as soon as possible."
State lawyers argued that the ban was
needed to "ensure humanity's continued existence."
"The continued expansion of the
population through stable birth rate growth fosters long-term
economic stability, unquestionably a valid state interest," the
state argued.
Heyburn dismissed the arguments as "not
those of serious people."
Kentucky Governor Steve Beshear, a
Democrat, hired private attorneys for the case after Attorney General
Jack Conway announced that he would not defend in court Kentucky's
2004 voter-approved constitutional amendment limiting marriage to
heterosexual couples.
(Related: Kentucky
AG refuses to defend gay marriage ban; Gov. to hire outside counsel.)
(Ruling provided by Equality
Case Files.)
On Top Magazine


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Lost A Sale, But Initial Phone Consultations — A Big Part Of Brilliant Customer Service
I just got finished with a ...
quick linksCURRENT ISSUE PREVIOUS ISSUES NEWS INDUSTRY NEWS COLUMNISTS BROWSE EDITORIAL TOPICS WEBINARS
resourcesABOUT MT AUTHOR GUIDELINES CLASSIFIEDS EDITORIAL CALENDAR MEDIA GUIDE MASSAGE MART SCHOOLS & EDUCATION FEEDBACK
Practice Policy (Gone Bad): The Sign
Every once in a while, you see something and think to yourself, That's a really bad idea. Case in point: I went to see my medical doctor the other day. Just after being "roomed," as they say, the nurse checked my vital signs. Then she left.
Dorsiflexion Dysfunction: Evaluation & Manipulation Techniques
Almost every condition from the foot to the hip can be attributed to the inability to dorsiflex the ankle mortice and other joints that participate in dorsiflexion. Let's start by understanding normal versus abnormal dorsiflexion.
A Chiropractor's Guide to Yoga
"Doctor, can I continue to do yoga while undergoing your care?" "Is it OK for me to go back to yoga while I'm getting my back treated?" "It is safe to start my yoga classes again after my neck pain improves?"
More Chiropractors Required
An intriguing study published in the Journal of the American Board of Family Medicine examines how "chiropractic care affects use of primary care physician (PCP) services."
Fertility and Poly-Unsaturated Fatty Acids
Starting or expanding one's family is a major milestone. It's something that more and more people seek out health care advice and support for.
Nuts Reduce Risk of Heart Disease, Cancer and Other Health Problems
Several recent studies suggest regular consumption of nuts may provide a significant degree of protection against certain types of cancer, heart disease, possibly type 2 diabetes and some neurodegenerative diseases.
Change Lives by Supporting Chiropractic Research: Are You In?
The Palmer Center for Chiropractic Research (PCCR), in celebration of its 20th anniversary, has announced it is spearheading a fund-raising campaign to support chiropractic research.
The Short Leg Dilemma
When evaluating a new patient, it is common to note a relative shortening of one leg to the other. Some patients will even tell you they have one, and then pull out the store-bought heel lift they read about online.
Fish Oil: A Key Component of Positive Clinical Outcomes
Patients seem to be presenting with more complex problems, and many are responding to care more slowly or have completely unexpected results. Why?
Patient-Centered Care vs. Payer Restrictions: Your Ethical Obligation
Do you have an ethical obligation to evaluate your patients, make a diagnosis and provide evidence-based, patient-centered health care, irrelevant to the payer restrictions?
The New Age of Communication
In the age of technology, everyone, including the patient, is seeking faster, easier ways to communicate. With a wealth of social media, blogs, websites and videos, we are constantly barraged with information – to the point of overload.
Do Some Good and Grow Your Business with Cause Marketing
Cause marketing is truly one of the best ways that you can promote your services as a acupuncture professional. Cause marketing refers to a type of marketing where a business partners with a non-profit organization to help bring awareness to a charitable cause.
Modernization of Chinese Medicine
Language – written, spoken, signed, or otherwise is learned as a means to express our individualized perceptions about the world around us. Language is designed to communicate our personal experiences.
Getting a YES: An Effective Strategy for Overcoming Patient Objections
Patients make more excuses for declining care from an acupuncturist than perhaps any other type of doctor. Various reasons hold them back from making a commitment to care.
Harvard Health References Flawed AHA Position Paper
In its special health report, "Stroke: Diagnosing, Treating, and Recovering From a 'Brain Attack,'" Harvard Health Publications includes information from the American Heart Association's 2014 position statement on cervical manipulation and cervical dissection – a statement the American Chiropractic Association emphasized in a letter to Harvard Health mixes "scientific facts with half-truths."
The Food Conversation: Nutrition and Your Practice
It's morning and your first patient rolls in with a triple espresso steaming in one hand and a frazzled, desperate look in her eye. "You gotta help me, doc, I am constipated unless I drink one of these, and I am exhausted and anxious all the time."
Oriental Medicine on the World Stage
"Let me win. But if I cannot win, let me be brave in the attempt." This simple, yet powerful statement was lived out time and time again by so many of the athletes from around the world during the Special Olympics World Games in Los Angeles.
Practicing with Authenticity
To extrapolate from the above quote, patients love healthcare providers they can trust. One way to earn the trust of your patients is by practicing with authenticity. What does that mean, exactly?
Acupuncture Rising: From Acupuncture Anesthesia to Assisted-IVF, Part 1
Acupuncture's cultural and historical roots go back to the emergence of Chinese civilization. For more than 2,000 years, acupuncture needling has been continuously practiced on the largest population in the world.
News in Brief
Call for Abstracts Announced - Parker Las Vegas 2016; Logan Adds Doctorate Degree; New Role for Dr. James Edwards.
Healing Trauma: Cultivating Resilience and Presence Through Mindfulness, Part 2
In the last issue of Acupuncture Today, the first part of this article introduced the topic of trauma and resilience, and their relationship to the autonomic nervous system response and the concept of the spirit being grounded in the body, and suggested the importance of mindfulness as a tool for healing.
An Acupuncturist's View of Medicinal Marijuana
The use of cannabis for medical purposes is very controversial. Use as a panacea by physicians uninitiated to the proper application of herbal medicine, as well as an excuse for recreational use have greatly confused the issue.
The Zen Art of "One Point"
We were always told in our Zen Shiatsu training (by Japanese and Japanese American instructors) that our ultimate aim was to to find that "One Point." To be so focused we could touch just one point to transform Qi throughout a client's body.
Help: A Need at Every Level
One of the great gifts of training in acupuncture is the ability to take good care of oneself. I recently had a bout of frozen shoulder — an inflammatory syndrome which can be debilitatingly painful and take years to resolve.
Surprising Reasons for Orthotic Efficacy
Clinical outcome studies show orthotics are effective in the management of a wide range of injuries, including plantar fasciitis, Achilles tendinitis and patellofemoral pain syndrome.
What's Chiropractic Research Worth to You?
The Palmer Center for Chiropractic Research (PCCR), in celebration of its 20th anniversary, has announced it is spearheading a fundraising campaign to support chiropractic research.
Improving Communication Between AOM and Biomedical Providers
How comfortable do you feel talking to Western medical providers? If you are like me, you may not feel as comfortable as you would like. Some of my interactions with MD's haven't been the fruitful steps toward integrative medicine for which I had hoped.
August, 2011, Vol. 11, Issue 08
Investigating the Physiology of Massage
By Massage Therapy Foundation Contributor
In this month's Massage Therapy Foundation Research Column, we are exploring how massage works on a physiological level. While massage has been shown to be effective in various settings - little is known about the mechanism of how massage produces its benefits.It is commonly thought that at least some of the effects of massage come from alleviating muscle tension. However, it has yet to be conclusively shown to reduce the underlying neural activity (tone) in the muscle. Who hasn't asked or been asked, "Where are you experiencing tension today?" as Langdon Roberts asks in his article published in the March 2011 issue of the open access International Journal of Therapeutic Massage and Bodywork.
Langdon Roberts, MA, CMT, of the Center for Transformational Neurophysiology in Soquel, Calif., investigated this issue in a study entitled "Pressure Application and Resting EMG." Using surface electromyography (EMG) to measure muscle activity, Roberts hoped to quantify the exact change in muscle activity during two types of massage - light, medium and deep massage applied in the order of increasing pressure (IP) or decreasing pressure (DP). In this study, the electrical activity generated was measured in the m. rectus femoris of the left legs of twenty-five individuals. Roberts hypothesized that muscle activity would be lower after either massage, with IP resulting in significantly lower EMG activity than DP.
Roberts writes, "[When] Goldberg et al. compared light and deep petrissage to the triceps surae [...] deep massage produced a greater reduction in the H-reflex, an electrical analog of the stretch reflex." The H-reflex (Hoffman reflex) is a measure of spinal cord excitability. Roberts cites other research that appears to link a reduction in H-reflex and massage, although he notes H-reflex hasn't been linked to pain reduction or any other known benefits of massage.
Roberts used a clinical crossover design in this study, meaning all 25 individuals received both IP and DP massage, with at least four weeks in between. The ethics of Roberts' study protocol were approved by an internal review board at the Muscular Therapy Institute in Cambridge, Mass. The massage setup was simple, with electromyography electrodes placed proximally and distally to the left rectus femoris, at its musculotendinous junctions. Each massage session was composed of three strokes for each level of pressure to each leg's rectus femoris, beginning with the left leg.
Roberts solicited the three levels of pressure as: "light, but not insubstantial," "moderate" and "as deep as possible without causing pain or a sensation of increased muscle tension." Each slow stroke was performed in a toward-proximal direction and lasted for 15 seconds. Two minutes elapsed between each pressure level. The massage therapist wore thumbtip pressure sensors and applied the strokes using adjacent thumbs. These gloved sensors showed that people in the IP and DP group preferred different objective vs. subjective pressure levels as indicated in a repeated-measures ANOVA [p<0.02]. Further study may show that subjects who receive deep pressure first require a deeper objective pressure to get to a pressure subjectively on the border of pain. In other words, clients may be able to withstand deeper pressure when it is used first. Unfortunately, equipment malfunctions prevented a test of this hypothesis in this study; only 14 subjects had "reliable" data available for statistical analysis.
The EMG results, while surprising, confirm many massage therapists' intuition. Using repeated-measures ANOVA on a group with all DP data, Roberts found, "EMG varied significantly across the four time points [p < 0.03]." In the DP data the application of deep pressure without previous massage caused a sudden increase in muscle activity, which diminished when lighter pressure was later used. This was not the case with the IP group, where "IP data indicates that EMG did not vary significantly across the four times points [p = 0.71]." These results did not differ between the IP-first and DP-first groups [p = 0.30 & p = 0.38].
Although the individuals studied were mostly (>80%) women, this is typically true about the population that seeks massage therapy as well. Another limitation of the study is that different muscles may show different EMG results, since Roberts cites studies that show "a reduction of EMG activity after massage [...] consistently found only in the frontalis muscle." Notably, the massage in this study was applied only to the rectus femoris muscles that were already relaxed, not in pain or otherwise uncomfortable.
This study validates the use of EMG as a tool for investigating the physiological basis of massage. One potential subject for further study includes a comparison of the EMG methods used here - a MEDAC Sys/3 physiological monitor. Roberts recommends a system of "counting repeated minima during each collection period," which he suggests as superior to "counting mean values" because of the commonplace nature of EMG artifacts or false readings.
How can you apply the results of this study to your own practice? If your treatment goal is to reduce or minimize EMG activity, then you should begin with light pressure and gradually increase your pressure during effleurage strokes, especially on the large muscles of the quadriceps. Unfortunately, these results are limited to asymptomatic rectus femoris muscles studied in a small group of people by a single therapist. Further research may show that a DP style of massage consistently causes a sudden spike in EMG activity, and could relate that to patient outcomes. Research has not shown a link between EMG activity and subjective tension. According to Roberts, "Carlson et al. [found] no relationship between perceived tension and EMG activity in clients with muscle pain or in pain-free subjects." Roberts suggests it is likely that "multiple modulating factors" could be at play in the EMG results seen here.
The research reported here was funded by the Massage Therapy Foundation, the same foundation that supports this column. We hope Roberts' and others' research will elucidate to what extent endorphins, reflex pathways, and/or the "freeing of nociceptive or mechanoreceptive nerve endings" contribute to the physiological benefits of massage. For more information on the MTF, visit our website at www.massagetherapyfoundation.org/.
Source: Roberts, L. (2011). Effects of Patterns of Pressure Application on Resting Electromyography During Massage. International Journal Of Therapeutic Massage & Bodywork: Research, Education, & Practice, 4(1). Retrieved from www.ijtmb.org/index.php/ijtmb/article/view/25/154
Click here for more information about Massage Therapy Foundation Contributor.
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New City In The Sea song
Meh pretty bad by sumerian standards
Needs more red light bulbs
read this as 'A City Safe From Sea' for a second and got excited :/
@Inca haha
I like this band, I've been following them since their first EP but I do not think Sumerian Records is a good fit for them.
Digging: The Afterimage - Lumière
Kinda sucks, I think Sumerian made them change their sound too, they always has an unique sound. They were like August Burns Red but with strong Post Hardcore influences.
Didn't know Steven Stamkos fronted a shitty metalcore band
• Brand New release new song as a f..• Tool + Mastodon supergroup• Justin Lowe leaves After the Buri..• Slint guitarist survives suicide ..• Muse unleash new single• Justin Lowe found dead• Cynic break up• Scarlett Johansson forms band• Nickelback get groovy • New Muse song
• Flower Face debuts new single• Golden Void premiere new video• Hands Like Houses debut new song• Perturbator debuts music video• New Megadeth track and album• Fit for an Autopsy stream new LP• Deacon the Villain streams new LP• Coheed and Cambria stream third s..• Moby releases rock tune• Kauan debuts new video• Jr. Clooney release new EP• Night Birds stream Mutiny• The Matches reunite with new music• New Sunn O))) album• Entwine stream new album» see all news
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text: Tuition protest underway in Montreal Scenes from the demonstration (#manifencours) macleans.ca February 26, 2013 Twitter Facebook Google+ Share LinkedIn Reddit Email Twitter Facebook Google+ Share LinkedIn Reddit Email 0 To read about today's Quebec education summit, click here. [View the story "Scenes from the student demonstration in Montreal " on Storify] Twitter Facebook Google+ Share LinkedIn Reddit Email Filed under: education summit Quebec Sommet2013 tuition Advertisement About this author macleans.ca Macleans.ca administrator Other articles Maclean's on the Hill: The last week of a long campaign Author Joseph Boyden takes on Stephen Harper + 23 more posts this week Advertisement Post navigation Previous This or that? Figure out where you stand in this election Next Vote Canada 2015: 13 newsrooms, one hub for election updates


text:
Open Seminars
"Master Classes" by world-class teachers; open to all
Every year we invite some of the world's most respected and effective teachers of spiritual studies to present 'master classes' at our Lakeside Learning Center.
Many of these seminars are also broadcast simultaneously on-line as "Webinars" - (look for the WEB symbol beside the listings) - so if you cannot make the journey to be with us in person, you can also participate by computer in the comfort of your own home. You will be able to communicate with our webmaster throughout the seminar and have your own questions and comments put 'live' to the presenter.
You do not have to have attended any of our "Core Educational Programs" to attend these Seminars; they are open to everyone.
For details of how to register, either in person or as an on-line participant please see the individual Seminars.
2015 Schedule
Friday, October 9 - Monday, October 12
Fundamentals Of Restructuring
with Rev. Tom Cratsley, B.S.
Tom developed this break-though approach to healing to discover and release unconscious resistance patterns and heal them once and for all.
October 16 - 18
Spiritual Insight Training II
with Rev. Elaine D. Thomas, Rev. Jessie Furst, and Rev. Don Scott
You will experience higher levels in the development of your spiritual insight abilities through the refinement of your perceptions.
Fri., October 23 - Sun., October 25
Medical Intuition - Seeing with an X-Ray Eye
with Tina Zion
Learn one of the newest tools in complimentary health care. See what sophisticated diagnostic exams cannot determine.
Monday, October 26
Advanced Medical Intuition Training
with Tina Zion
This advanced class is for individuals who are recently aware of receiving medical intuitive information and for the professional already in practice.
Saturday, October 31
with Rocco Errico Ph.D., Th.D.
Taboo or not taboo? That is the question that both Jews and Christians must ask of their current religious sex ethic.