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Rockin Raclette
It was a relief when I stepped out of the house this morning and noticed there was still a strong chill in the March air. I'm just as ready for Spring as anyone else in New York, but tonight, balmy temperatures can wait. I'm making raclette.
While fondue enjoyed a brief celebrity moment in the 1970s, its Swiss cuisine cousin, raclette, has never experienced the same level of stardom in the States. Having eaten both dishes on many occasions while living in Switzerland, I still favor the less popular of the two cheese-based dishes.Traditional fondue makes a delicious meal, but becomes fairly monotone in flavor as you continue to eat hunks of baguette dipped inkirsch-scented gruyere. Raclette, on the other hand, has the same comfort food-quality and do-it-yourself fun, but with a wider variety of tastes. Always a fan of multiple flavor combinations within a single dish, I opt for raclette every time.
To host a decent raclette party, you need a few essential ingredients: a warm bowl of small boiled potatoes, a platter of dried meats (such as prosciutto and viande sache), cornichons, pickled pearl onions and slices of raclette cheese, a semi-firm cow's milk cheese traditionally from France or Switzerland. For the authentic effect it's necessary to have a steady blaze going in your fireplace that you can hang your wheel of raclette cheese next to, and serve it on plates to your guests as it melts and sloughs off (in this scenario, it's also helpful to have a cabin in the Alps). But, for most of us, a raclette machine will do (or, if truly breaking tradition, a microwave, stovetop or other cheese-melting device).
Once you have your ingredients in order, the process is simple. Guests can put any combination of potatoes, meat and pickled vegetables on their plates. Then, if you have one, they melt slices of cheese in the raclette machine's individual warming trays. Once the cheese is sufficiently oozy, they scrape the cheese on top of their other ingredients with a wide wooden stick. The dish's name derives from this finishing touch, as racler means 'to scrape' in French. It's a beautiful, cheesy mess on the plate, with each bite offering a different possibility – nutty raclette, the pleasant saltiness of dried meat, the acidic brightness of pickled vegetables and warm potatoes, a soft backdrop to the intense variety of flavors. To complete the meal, serve a simple green salad on the side and plenty of good riesling (water is a sacrilege at raclette parties, as it's said to harden the cheese in the stomach and create indigestion).
In the end, the bulky, square raclette machine on your dinner table might not be as sexy as a retro red fondue pot, but what it delivers is far better.
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A machine has 4GB RAM and the processor is 32 bits. The large screen (monitor) needs atleast 2^21 addresses and the machine already supports one screen with 1280x800 resolution which is equivalent to needing 1,024,000 addresses. The address space for a few other peripherals take at least another 2^21 addresses.
If you want all of the 4GB of RAM and all the peripheralds above including the large screen monitor to be accessible, how much bigger does the address bus need to be?
I am completely stuck on this question, if anyone can offer help that would be fantastic.
I look forward to hearing from anyone.

subset: commoncrawl


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text: Diabetes Complications http://diabetes.diabetesjournals.org Diabetes RSS feed -- recent Complications articles 1939-327X Diabetes 0012-1797 Diabetes http://diabetes.diabetesjournals.org/icons/banner/title.gif http://diabetes.diabetesjournals.org http://diabetes.diabetesjournals.org/cgi/content/short/64/10/3554?rss=1 To dissect the role of vascular endothelial growth factor receptor-2 (VEGFR2) in Müller cells and its effect on neuroprotection in diabetic retinopathy (DR), we disrupted VEGFR2 in mouse Müller glia and determined its effect on Müller cell survival, neuronal integrity, and trophic factor production in diabetic retinas. Diabetes was induced with streptozotocin. Retinal function was measured with electroretinography. Müller cell and neuronal densities were assessed with morphometric and immunohistochemical analyses. Loss of VEGFR2 caused a gradual reduction in Müller glial density, which reached to a significant level 10 months after the onset of diabetes. This observation was accompanied by an age-dependent decrease of scotopic and photopic electroretinography amplitudes and accelerated loss of rod and cone photoreceptors, ganglion cell layer cells, and inner nuclear layer neurons and by a significant reduction of retinal glial cell line–derived neurotrophic factor and brain-derived neurotrophic factor. Our results suggest that VEGFR2-mediated Müller cell survival is required for the viability of retinal neurons in diabetes. The genetically altered mice established in this study can be used as a diabetic animal model of nontoxin-induced Müller cell ablation, which will be useful for exploring the cellular mechanisms of neuronal alteration in DR. ]]> 2015-09-24T12:00:50-07:00 info:doi/10.2337/db15-0180 hwp:master-id:diabetes;db15-0180 American Diabetes Association 2015-10-01 Complications 64 10 3554 3563 http://diabetes.diabetesjournals.org/cgi/content/short/64/10/3564?rss=1 The objective of this study was to determine whether the sodium-glucose transporter SGLT1 in the ventromedial hypothalamus (VMH) plays a role in glucose sensing and in regulating the counterregulatory response to hypoglycemia, and if so, whether knockdown of in the VMH can improve counterregulatory responses to hypoglycemia in diabetic rats or rats exposed to recurrent bouts of hypoglycemia (RH). Normal Sprague-Dawley rats as well as RH or streptozotocin (STZ)-diabetic rats received bilateral VMH microinjections of an adenoassociated viral vector containing either the SGLT1 short hairpin RNA (shRNA) or a scrambled RNA sequence. Subsequently, these rats underwent a hypoglycemic clamp to assess hormone responses. In a subgroup of rats, glucose kinetics was determined using tritiated glucose. The shRNA reduced VMH SGLT1 expression by 53% in nondiabetic rats, and this augmented glucagon and epinephrine responses and hepatic glucose production during hypoglycemia. Similarly, SGLT1 knockdown improved the glucagon and epinephrine responses in RH rats and restored the impaired epinephrine response to hypoglycemia in STZ-diabetic animals. These findings suggest that SGLT1 in the VMH plays a significant role in the detection and activation of counterregulatory responses to hypoglycemia. Inhibition of SGLT1 may offer a potential therapeutic target to diminish the risk of hypoglycemia in diabetes. ]]> 2015-09-24T12:00:50-07:00 info:doi/10.2337/db15-0022 hwp:master-id:diabetes;db15-0022 American Diabetes Association 2015-10-01 Complications 64 10 3564 3572 http://diabetes.diabetesjournals.org/cgi/content/short/64/10/3573?rss=1 Contractile dysfunction and increased deposition of O-linked β-N-acetyl-d-glucosamine (O-GlcNAc) in cardiac proteins are a hallmark of the diabetic heart. However, whether and how this posttranslational alteration contributes to lower cardiac function remains unclear. Using a refined β-elimination/Michael addition with tandem mass tags (TMT)–labeling proteomic technique, we show that CpOGA, a bacterial analog of O-GlcNAcase (OGA) that cleaves O-GlcNAc in vivo, removes site-specific O-GlcNAcylation from myofilaments, restoring Ca2+ sensitivity in streptozotocin (STZ) diabetic cardiac muscles. We report that in control rat hearts, O-GlcNAc and O-GlcNAc transferase (OGT) are mainly localized at the Z-line, whereas OGA is at the A-band. Conversely, in diabetic hearts O-GlcNAc levels are increased and OGT and OGA delocalized. Consistent changes were found in human diabetic hearts. STZ diabetic hearts display increased physical interactions of OGA with α-actin, tropomyosin, and myosin light chain 1, along with reduced OGT and increased OGA activities. Our study is the first to reveal that specific removal of O-GlcNAcylation restores myofilament response to Ca2+ in diabetic hearts and that altered O-GlcNAcylation is due to the subcellular redistribution of OGT and OGA rather than to changes in their overall activities. Thus, preventing sarcomeric OGT and OGA displacement represents a new possible strategy for treating diabetic cardiomyopathy. ]]> 2015-09-24T12:00:50-07:00 info:doi/10.2337/db14-1107 hwp:master-id:diabetes;db14-1107 American Diabetes Association 2015-10-01 Complications 64 10 3573 3587 http://diabetes.diabetesjournals.org/cgi/content/short/64/10/3588?rss=1 This study characterizes the kallikrein-kinin system in vitreous from individuals with diabetic macular edema (DME) and examines mechanisms contributing to retinal thickening and retinal vascular permeability (RVP). Plasma prekallikrein (PPK) and plasma kallikrein (PKal) were increased twofold and 11.0-fold (both P < 0.0001), respectively, in vitreous from subjects with DME compared with those with a macular hole (MH). While the vascular endothelial growth factor (VEGF) level was also increased in DME vitreous, PKal and VEGF concentrations do not correlate (r = 0.266, P = 0.112). Using mass spectrometry–based proteomics, we identified 167 vitreous proteins, including 30 that were increased in DME (fourfold or more, P < 0.001 vs. MH). The majority of proteins associated with DME displayed a higher correlation with PPK than with VEGF concentrations. DME vitreous containing relatively high levels of PKal and low VEGF induced RVP when injected into the vitreous of diabetic rats, a response blocked by bradykinin receptor antagonism but not by bevacizumab. Bradykinin-induced retinal thickening in mice was not affected by blockade of VEGF receptor 2. Diabetes-induced RVP was decreased by up to 78% (P < 0.001) in Klkb1 (PPK)-deficient mice compared with wild-type controls. B2- and B1 receptor–induced RVP in diabetic mice was blocked by endothelial nitric oxide synthase (NOS) and inducible NOS deficiency, respectively. These findings implicate the PKal pathway as a VEGF-independent mediator of DME. ]]> 2015-09-24T12:00:50-07:00 info:doi/10.2337/db15-0317 hwp:master-id:diabetes;db15-0317 American Diabetes Association 2015-10-01 Complications 64 10 3588 3599 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3253?rss=1 The aim of this study was to determine whether antecedent stimulation of -aminobutyric acid (GABA) A receptors with the benzodiazepine alprazolam can blunt physiologic responses during next-day moderate (90 min) exercise in healthy man. Thirty-one healthy individuals (16 male/15 female aged 28 ± 1 year, BMI 23 ± 3 kg/m2) were studied during separate, 2-day protocols. Day 1 consisted of morning and afternoon 2-h hyperinsulinemic-euglycemic or hypoglycemic clamps with or without 1 mg alprazolam given 30 min before a clamp. Day 2 consisted of 90-min euglycemic cycling exercise at 50% VO2max. Despite similar euglycemia (5.3 ± 0.1 mmol/L) and insulinemia (46 ± 6 pmol/L) during day 2 exercise studies, GABA A activation with alprazolam during day 1 euglycemia resulted in significant blunting of plasma epinephrine, norepinephrine, glucagon, cortisol, and growth hormone responses. Lipolysis (glycerol, nonesterified fatty acids) and endogenous glucose production during exercise were also reduced, and glucose infusion rates were increased following prior euglycemia with alprazolam. Prior hypoglycemia with alprazolam resulted in further reduction of glucagon and cortisol responses during exercise. We conclude that prior activation of GABA A pathways can play a significant role in blunting key autonomous nervous system, neuroendocrine, and metabolic physiologic responses during next-day exercise in healthy man. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db15-0212 hwp:master-id:diabetes;db15-0212 American Diabetes Association 2015-09-01 Complications 64 9 3253 3261 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3262?rss=1 Production of adrenomedullin (ADM), a vasodilator peptide, increases in response to ischemia and hypoxia in the vascular wall and the kidney. This may be an adaptive response providing protection against organ damage. We investigated the hypothesis that ADM has a nephroprotective effect in two prospective cohorts of patients with type 2 diabetes recruited in France. The highest tertile of plasma MR-proADM (a surrogate for ADM) concentration at baseline was associated with the risk of renal outcomes (doubling of plasma creatinine concentration and/or progression to end-stage renal disease) during follow-up in both cohorts. Four SNPs in the ADM gene region were associated with plasma MR-proADM concentration at baseline and with eGFR during follow-up in both cohorts. The alleles associated with lower eGFR were also associated with lower plasma MR-proADM level. In conclusion, plasma MR-proADM concentration was associated with renal outcome in patients with type 2 diabetes. Our data suggest that the ADM gene modulates the genetic susceptibility to nephropathy progression. Results are consistent with the hypothesis of a reactive rise of ADM in diabetic nephropathy, blunted in risk alleles carriers, and with a nephroprotective effect of ADM. A possible therapeutic effect of ADM receptor agonists in diabetic renal disease would be worth investigating. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db14-1852 hwp:master-id:diabetes;db14-1852 American Diabetes Association 2015-09-01 Complications 64 9 3262 3272 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3273?rss=1 The assumption underlying current diabetes treatment is that lowering the level of time-averaged glucose concentrations, measured as HbA1c, prevents microvascular complications. However, 89% of variation in risk of retinopathy, microalbuminuria, or albuminuria is due to elements of glycemia not captured by mean HbA1c values. We show that transient exposure to high glucose activates a multicomponent feedback loop that causes a stable left shift of the glucose concentration-reactive oxygen species (ROS) dose-response curve. Feedback loop disruption by the GLP-1 cleavage product GLP-1(9–36)amide reverses the persistent left shift, thereby normalizing persistent overproduction of ROS and its pathophysiologic consequences. These data suggest that hyperglycemic spikes high enough to activate persistent ROS production during subsequent periods of normal glycemia but too brief to affect the HbA1c value are a major determinant of the 89% of diabetes complications risk not captured by HbA1c. The phenomenon and mechanism described in this study provide a basis for the development of both new biomarkers to complement HbA1c and novel therapeutic agents, including GLP-1(9–36)amide, for the prevention and treatment of diabetes complications. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db15-0084 hwp:master-id:diabetes;db15-0084 American Diabetes Association 2015-09-01 Complications 64 9 3273 3284 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3285?rss=1 We investigated whether circulating TGF-β1–regulated miRNAs detectable in plasma are associated with the risk of rapid progression to end-stage renal disease (ESRD) in a cohort of proteinuric patients with type 1 diabetes (T1D) and normal eGFR. Plasma specimens obtained at entry to the study were examined in two prospective subgroups that were followed for 7–20 years (rapid progressors and nonprogressors), as well as a reference panel of normoalbuminuric T1D patients. Of the five miRNAs examined in this study, let-7c-5p and miR-29a-3p were significantly associated with protection against rapid progression and let-7b-5p and miR-21-5p were significantly associated with the increased risk of ESRD. In logistic analysis, controlling for HbA1c and other covariates, let-7c-5p and miR-29a-3p were associated with more than a 50% reduction in the risk of rapid progression (P ≤ 0.001), while let-7b-5p and miR-21-5p were associated with a >2.5-fold increase in the risk of ESRD (P ≤ 0.005). This study is the first prospective study to demonstrate that circulating TGF-β1–regulated miRNAs are deregulated early in T1D patients who are at risk for rapid progression to ESRD. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db15-0116 hwp:master-id:diabetes;db15-0116 American Diabetes Association 2015-09-01 Complications 64 9 3285 3293 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3294?rss=1 To define the components of the metabolic syndrome that contribute to diabetic polyneuropathy (DPN) in type 2 diabetes mellitus (T2DM), we treated the BKS db/db mouse, an established murine model of T2DM and the metabolic syndrome, with the thiazolidinedione class drug pioglitazone. Pioglitazone treatment of BKS db/db mice produced a significant weight gain, restored glycemic control, and normalized measures of serum oxidative stress and triglycerides but had no effect on LDLs or total cholesterol. Moreover, although pioglitazone treatment normalized renal function, it had no effect on measures of large myelinated nerve fibers, specifically sural or sciatic nerve conduction velocities, but significantly improved measures of small unmyelinated nerve fiber architecture and function. Analyses of gene expression arrays of large myelinated sciatic nerves from pioglitazone-treated animals revealed an unanticipated increase in genes related to adipogenesis, adipokine signaling, and lipoprotein signaling, which likely contributed to the blunted therapeutic response. Similar analyses of dorsal root ganglion neurons revealed a salutary effect of pioglitazone on pathways related to defense and cytokine production. These data suggest differential susceptibility of small and large nerve fibers to specific metabolic impairments associated with T2DM and provide the basis for discussion of new treatment paradigms for individuals with T2DM and DPN. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db15-0133 hwp:master-id:diabetes;db15-0133 American Diabetes Association 2015-09-01 Complications 64 9 3294 3304 http://diabetes.diabetesjournals.org/cgi/content/short/64/9/3305?rss=1 Metformin is an antihyperglycemic drug that is widely prescribed for type 2 diabetes mellitus and is currently being investigated for the treatment of nonalcoholic steatohepatitis (NASH). NASH is known to alter hepatic membrane transporter expression and drug disposition similarly in humans and rodent models of NASH. Metformin is almost exclusively eliminated through the kidney primarily through active secretion mediated by Oct1, Oct2, and Mate1. The purpose of this study was to determine how NASH affects kidney transporter expression and metformin pharmacokinetics. A single oral dose of [14C]metformin was administered to C57BL/6J (wild type [WT]) and diabetic ob/ob mice fed either a control diet or a methionine- and choline-deficient (MCD) diet. Metformin plasma concentrations were slightly increased in the WT/MCD and ob/control groups, whereas plasma concentrations were 4.8-fold higher in ob/MCD mice compared with WT/control. The MCD diet significantly increased plasma half-life and mean residence time and correspondingly decreased oral clearance in both genotypes. These changes in disposition were caused by ob/ob- and MCD diet–specific decreases in the kidney mRNA expression of Oct2 and Mate1, whereas Oct1 mRNA expression was only decreased in ob/MCD mice. These results indicate that the diabetic ob/ob genotype and the MCD disease model alter kidney transporter expression and alter the pharmacokinetics of metformin, potentially increasing the risk of drug toxicity. ]]> 2015-08-20T12:00:51-07:00 info:doi/10.2337/db14-1947 hwp:master-id:diabetes;db14-1947 American Diabetes Association 2015-09-01 Complications 64 9 3305 3313 http://diabetes.diabetesjournals.org/cgi/content/short/64/8/2969?rss=1 Previous studies suggest that diabetes impairs hematopoietic stem cell (HSC) mobilization in response to granulocyte colony-stimulating factor (G-CSF). In this study, we tested whether the CXCR4 antagonist plerixafor, differently from G-CSF, is effective in mobilizing HSCs in patients with diabetes. In a prospective study, individuals with and without diabetes (n = 10/group) were administered plerixafor to compare CD34+ HSC mobilization; plerixafor was equally able to mobilize CD34+ HSCs in the two groups, whereas in historical data, G-CSF was less effective in patients with diabetes. In a retrospective autologous transplantation study conducted on 706 patients, diabetes was associated with poorer mobilization in patients who received G-CSF with/without chemotherapy, whereas it was not in patients who received G-CSF plus plerixafor. Similarly in an allogeneic transplantation study (n = 335), diabetes was associated with poorer mobilization in patients who received G-CSF. Patients with diabetes who received G-CSF without plerixafor had a lower probability of reaching >50/μL CD34+ HSCs, independent from confounding variables. In conclusion, diabetes negatively impacted HSC mobilization after G-CSF with or without chemotherapy but had no effect on mobilization induced by G-CSF with plerixafor. This finding has major implications for the care of patients with diabetes undergoing stem cell mobilization and transplantation and for the vascular regenerative potential of bone marrow stem cells. ]]> 2015-07-23T12:00:58-07:00 info:doi/10.2337/db15-0077 hwp:master-id:diabetes;db15-0077 American Diabetes Association 2015-08-01 Complications 64 8 2969 2977 http://diabetes.diabetesjournals.org/cgi/content/short/64/8/2978?rss=1 Diabetic nephropathy is the leading cause of end-stage renal disease. It is pathologically characterized by the accumulation of extracellular matrix in the mesangium, of which the main component is α1/α2 type IV collagen (Col4a1/a2). Recently, we identified Smad1 as a direct regulator of Col4a1/a2 under diabetic conditions in vitro. Here, we demonstrate that Smad1 plays a key role in diabetic nephropathy through bone morphogenetic protein 4 (BMP4) in vivo. Smad1-overexpressing mice (Smad1-Tg) were established, and diabetes was induced by streptozotocin. Nondiabetic Smad1-Tg did not exhibit histological changes in the kidney; however, the induction of diabetes resulted in an ~1.5-fold greater mesangial expansion, consistent with an increase in glomerular phosphorylated Smad1. To address regulatory factors of Smad1, we determined that BMP4 and its receptor are increased in diabetic glomeruli and that diabetic Smad1-Tg and wild-type mice treated with a BMP4-neutralizing antibody exhibit decreased Smad1 phosphorylation and ~40% less mesangial expansion than those treated with control IgG. Furthermore, heterozygous Smad1 knockout mice exhibit attenuated mesangial expansion in the diabetic condition. The data indicate that BMP4/Smad1 signaling is a critical cascade for the progression of mesangial expansion and that blocking this signal could be a novel therapeutic strategy for diabetic nephropathy. ]]> 2015-07-23T12:00:58-07:00 info:doi/10.2337/db14-0893 hwp:master-id:diabetes;db14-0893 American Diabetes Association 2015-08-01 Complications 64 8 2978 2990 http://diabetes.diabetesjournals.org/cgi/content/short/64/8/2991?rss=1 Staphylococcus aureus is an opportunistic bacterium capable of causing a wide range of severe diseases when it gains access to underlying tissues. Paradoxically, S. aureus is a common inhabitant of the skin microflora and colonizes the nares and other human mucosa. The purpose of this study was to determine the genetic basis for the differences in the pathogenic versus colonizing potential of S. aureus isolated from diabetic foot ulcers (DFUs). By performing optical map comparisons of a collection of S. aureus strains isolated from DFUs, we brought to light a prophage present in noninfecting bacteria. The phage, namely ROSA-like, was localized in a hotspot region NM2 near the locus isd, the iron surface determinant system. The integrated phage significantly reduces the virulence of the strain and increases the biofilm formation. DFUs seem to be a specific niche of this colonizing strain. The ROSA-like phage represents the first description of a mobile element present mainly in S. aureus isolated from DFUs, which modulates the relationship of the bacteria with its human host. This phage appears to attenuate bacterial virulence and promote colonization. ]]> 2015-07-23T12:00:58-07:00 info:doi/10.2337/db15-0031 hwp:master-id:diabetes;db15-0031 American Diabetes Association 2015-08-01 Complications 64 8 2991 2995 http://diabetes.diabetesjournals.org/cgi/content/short/64/7/2560?rss=1 Despite treatment advances, diabetic eye disease remains a leading cause of visual acuity (VA) loss worldwide. No methods to prospectively determine which patients will gain or lose vision exist, limiting individualized risk assessment and management. We investigated whether noninvasive, readily obtainable spectral domain optical coherence tomography parameters were correlated with VA in eyes with current or resolved center-involved diabetic macular edema (DME). Images were evaluated for disorganization of the retinal inner layers (DRIL), cysts, epiretinal membranes, microaneurysms, subretinal fluid, and outer layer disruption/reflectivity. DRIL affecting ≥50% of the 1-mm central retinal zone was associated with worse VA in all eyes, eyes with current edema, and eyes with resolved edema. Furthermore, early 4-month change in DRIL extent predicted VA change from baseline to 1 year. These data suggest that DRIL is a robust predictor of VA in eyes with present or previous DME and more highly correlated with VA than other widely used measures, such as retinal thickness. If further studies confirm DRIL as a predictive biomarker of future VA, physicians would gain a new tool of substantial clinical and investigative importance that could significantly change the approach to ophthalmic counseling and therapeutic management in patients with diabetes. ]]> 2015-06-23T12:00:56-07:00 info:doi/10.2337/db14-0782 hwp:master-id:diabetes;db14-0782 American Diabetes Association 2015-07-01 Complications 64 7 2560 2570 http://diabetes.diabetesjournals.org/cgi/content/short/64/7/2571?rss=1 The aim of this study was to determine the effects of single and repeated episodes of clamped hypoglycemia on fibrinolytic balance, proinflammatory biomarkers, proatherothrombotic mechanisms, and endothelial function. Twenty healthy individuals (12 male and 8 female) were studied during separate 2-day randomized protocols. Day 1 consisted of either two 2-h hyperinsulinemic (812 ± 50 pmol/L)-euglycemic (5 ± 0.1 mmol/L) or hyperinsulinemic (812 ± 50 pmol/L)-hypoglycemic (2.9 ± 0.1 mmol/L) clamps. Day 2 consisted of a single 2-h hyperinsulinemic-hypoglycemic clamp. Two-dimensional Doppler ultrasound was used to determine brachial arterial endothelial function. Plasminogen activator inhibitor 1, vascular cell adhesion molecule-1, intracellular adhesion molecule-1, E-selectin, P-selectin, TAT (thrombin/antithrombin complex), tumor necrosis factor-α, and interleukin-6 responses were increased (P < 0.05) during single or repeated hypoglycemia compared with euglycemia. Endogenous and exogenous nitric oxide (NO)-mediated vasodilation were both impaired by repeated hypoglycemia. Neuroendocrine and autonomic nervous system (ANS) responses were also blunted by repeated hypoglycemia (P < 0.05). In summary, acute moderate hypoglycemia impairs fibrinolytic balance; increases proinflammatory responses, platelet activation, and coagulation biomarkers; and reduces NO-mediated endothelial function in healthy individuals. Repeated episodes of hypoglycemia further impair vascular function by additionally reducing exogenously NO-mediated endothelial function and increasing coagulation biomarkers. We conclude that despite reduced neuroendocrine and ANS responses, antecedent hypoglycemia results in greater endothelial dysfunction and an increased proatherothrombotic state compared with a single acute episode of hypoglycemia. ]]> 2015-06-23T12:00:56-07:00 info:doi/10.2337/db14-1729 hwp:master-id:diabetes;db14-1729 American Diabetes Association 2015-07-01 Complications 64 7 2571 2580 http://diabetes.diabetesjournals.org/cgi/content/short/64/7/2581?rss=1 Vascular endothelial growth factor (VEGF) blockers have been developed for the treatment of proliferative diabetic retinopathy (PDR), the leading cause of visual impairments in the working-age population in the Western world. However, limitations to anti-VEGF therapies may exist because of the local production of other proangiogenic factors that may cause resistance to anti-VEGF interventions. Thus, novel therapeutic approaches targeting additional pathways are required. Here, we identified a sulfated derivative of the Escherichia coli polysaccharide K5 [K5-N,OS(H)] as a multitarget molecule highly effective in inhibiting VEGF-driven angiogenic responses in different in vitro, ex vivo, and in vivo assays, including a murine model of oxygen-induced retinopathy. Furthermore, K5-N,OS(H) binds a variety of heparin-binding angiogenic factors upregulated in PDR vitreous humor besides VEGF, thus inhibiting their biological activity. Finally, K5-N,OS(H) hampers the angiogenic activity exerted in vitro and in vivo by human vitreous fluid samples collected from patients with PDR. Together, the data provide compelling experimental evidence that K5-N,OS(H) represents an antiangiogenic multitarget molecule with potential implications for the therapy of pathologic neovessel formation in the retina of patients with PDR. ]]> 2015-06-23T12:00:56-07:00 info:doi/10.2337/db14-1378 hwp:master-id:diabetes;db14-1378 American Diabetes Association 2015-07-01 Complications 64 7 2581 2592 http://diabetes.diabetesjournals.org/cgi/content/short/64/7/2593?rss=1 Diabetes impairs the ability to heal cutaneous wounds, leading to hospitalization, amputations, and death. Patients with diabetes experience elevated levels of plasminogen activator inhibitor 1 (PAI-1), regardless of their glycemic control. It has been demonstrated that PAI-1–deficient mice exhibit improved cutaneous wound healing, and that PAI-1 inhibition improves skeletal muscle repair in mice with type 1 diabetes mellitus, leading us to hypothesize that pharmacologically mediated reductions in PAI-1 using PAI-039 would normalize cutaneous wound healing in streptozotocin (STZ)-induced diabetic (STZ-diabetic) mice. To simulate the human condition of variations in wound care, wounds were aggravated or minimally handled postinjury. Following cutaneous injury, PAI-039 was orally administered twice daily for 10 days. Compared with nondiabetic mice, wounds in STZ-diabetic mice healed more slowly. Wound site aggravation exacerbated this deficit. PAI-1 inhibition had no effect on dermal collagen levels or wound bed size. PAI-039 treatment failed to improve angiogenesis in the wounds of STZ-diabetic mice and blunted angiogenesis in the wounds of nondiabetic mice. Importantly, PAI-039 treatment significantly improved epidermal cellular migration and wound re-epithelialization compared with vehicle-treated STZ-diabetic mice. These findings support the use of PAI-039 as a novel therapeutic agent to improve diabetic wound closure and demonstrate the primary mechanism of its action to be related to epidermal closure. ]]> 2015-06-23T12:00:56-07:00 info:doi/10.2337/db14-1174 hwp:master-id:diabetes;db14-1174 American Diabetes Association 2015-07-01 Complications 64 7 2593 2602 http://diabetes.diabetesjournals.org/cgi/content/short/64/7/2603?rss=1 The paucity of animal models exhibiting full pathology of diabetic retinopathy (DR) has impeded understanding of the pathogenesis of DR and the development of therapeutic interventions. Here, we investigated whether hyperhexosemic marmosets (Callithrix jacchus) develop characteristic retinal vascular lesions including macular edema (ME), a leading cause of vision loss in DR. Marmosets maintained on 30% galactose (gal)-rich diet for 2 years were monitored for retinal vascular permeability, development of ME, and morphological characteristics including acellular capillaries (AC) and pericyte loss (PL), vessel tortuosity, and capillary basement membrane (BM) thickness. Excess vascular permeability, increased number of AC and PL, vascular BM thickening, and increased vessel tortuosity were observed in the retinas of gal-fed marmosets. Optical coherence tomography (OCT) images revealed significant thickening of the retinal foveal and the juxtafoveal area, and histological analysis showed incipient microaneurysms in retinas of gal-fed marmosets. Findings from this study indicate that hyperhexosemia can trigger retinal vascular changes similar to those seen in human DR including ME and microaneurysms. The striking similarities between the marmoset retina and the human retina, and the exceptionally small size of the monkey, offer significant advantages to this primate model of DR. ]]> 2015-06-23T12:00:56-07:00 info:doi/10.2337/db14-0866 hwp:master-id:diabetes;db14-0866 American Diabetes Association 2015-07-01 Complications 64 7 2603 2608


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Tried this restarant for the first time in Detroit, MI. This one is even better. Great ambiance makes for a great date place. Try all of the sauces with the fish, but avoid the steaks.Like this review?Yes|Flag AbuseProvided by Citysearch
Bonefish Grill
Today:4:00 pm - 10:30 pm
Tomorrow:4:00 pm - 10:30 pm
1260 Bower Pkwy,
Columbia, SC 29212
(803) 407-1599
Business Details
in Business
- Hours:
Regular Hours
- Payment method:
- amex, discover, master card, visa, all major credit cards
- Neighborhood:
- Northwest Columbia
- Other Link:
- Other Email:
- Categories:
- Seafood Restaurants, Bar & Grills, Restaurants, American Restaurants, Steak Houses
I constantly eat out and I'd like to think that I've been to most restaurants in Columbia(at least 90% of them) and the Bonefish Grill has instantly become my favorite! The service was impeccable and when you walk in the dining-room you automatically assume you are going to enjoy your meal and you would be correct to do so. Despite there being a packed house my date and I were able to carry on a delightul conversatio... view moreLike this review?Yes|Flag AbuseProvided by Citysearch


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Are you a Pokémon Purist?
MOD NOTE: Yes, this is originally from 2012, but we've decided to leave this thread open (see post 46), so feel free to continue posting here!
A Pokémon Purist is someone who typically holds the belief that the first generation is the best because it was the first, and usually hold that belief based on nostalgia and sentimentality. They believe they had the best towns, they had the best Pokémon, they had the best story line, they had the best gym leaders, they had the best replay value, etc. Some refuse to buy games of later generations because of this, some continue to buy them and play though them (thoroughly enjoying them), but still hold the belief that Gen I was better and they'll usually never change their opinion.
Are you a Pokémon Purist? If so, how much of one are you? If not, what is your opinion of Pokémon Purists?
Nooo I honestly can't stand Pokemon purists. Even if they're not the type to argue it with you, it still just...gets on my nerves. Yes, I do love the first generation out of nostalgia, I admit. I honestly don't like going back and playing it but I still love it because of the memories. But I wouldn't argue that the first is objectively the best in any way. Its graphics were terrible, its storyline was simplistic even compared to the rest of the games, its gameplay was flawed in ways that were fixed in later generations, it was full of bugs. I may be judgmental in that I hate when people claim it's the best even if they don't argue it with me but I can't help it because I just dislike that claim so much haha.
When I saw the thread title, the first thought that came to mind was team typing.
In the anime, some main protagonists always have the conventional Grass, Fire, and Water type-pokemon in their teams. Some examples of Purists would be Ash/Red, Gary/Blue, Cynthia, Bianca, Barry, and Cheren.
So I would say that I HAVE to include a Grass, Fire, and Water type Pokemon. So in that respect that is what I think of as sticking to that standard and nostalgic conventions of a protagonist/champion team.
But as a GEN 1 Purist, I would say I am not at all. I love GEN 1, but I love the other GEN's as well.
I am definitely not a pursit. Most of the 'purists' haven't even tried the games of latter generations.
Well, I think I kind of am, only except that I do like some Pokémon of the newer gens and it's not like I am so stubborn that no one can change my mind on it. It's just yeah, for all the reasons why purists are what they are. But I still don't like to refer to myself as one haha, if I could even be considered one.
Not at all. There are good and bad Pokemon from all generations and each region has its ups and downs. As for the games themselves, they're full of problems like glitches and sprites that look nothing like the real thing. Not to mention that you were forced to play as a boy back in those days.
Even the graphical and gameplay advancements from 1st to 2nd gen were astounding and if I feel like returning to Kanto, I'll just play Leaf Green, thanks. But one thing I miss from 1st gen was Persian's Slash going critical almost every time.
Overall however, the advances made since the original games outweighs any sense of "nostalgia" for the 1st gen. People who are 1st gen purists don't usually bother me unless they're trying to push their beliefs on me.
Im not. Sure, I love the first gen alot but I tried the others out too and I like them.
Oh no... I am not a Pokemon purist. I think saying the first gen is the best in every single aspect of the games themselves is pretty darn stubborn. Graphically, it's probably the worst. It was decent for its time, when it was released, but nowadays it's got nothing on Gen V.
I think of Pokemon purists as people with a limited mindset, they only consider one thing and don't care for the others.
As for me, no, I am not a ppurist. I love the whole franchise so much, I can't even imagine how one could be so hateful of the other generations.
Considering that I've never even beaten the Elite Four in Kanto - at all - I would say that I'm most definitely not a purist. Even so, I enjoy many Pokemon from the older generations. Each generation have their ups-and-downs and I notice that, though it did take me a while to warm up to the fourth generation, and the fifth generation was okay, but not something I was hooked on for a long time. When I see purists who don't care about anything but the first generation, it bothers me. I'm fine with the purists that I least acknowledge that the other generations exist, and have favorites from other generations. However, they just favor the first generation more Like many things, it depends on the level of purism and how much they act on it depends on how much I'm bothered by it. I'm talking in more of a general level, than just a game level, as there are purists when it comes to the anime, and just the designs on the Pokemon as well.
I prefer the original generation of Pokemon, but I don't hate the rest.
Oh no, I'm not one at all. I can't stand the purists. They rave and rant about all of the newer generations and how awesome the first is. I honestly don't like the first generation games very much. The only reason that they're in love with it all is because the feeling that their nostalgia gives them makes them feel better than their life makes them feel. They call the newest gen "the worst yet" saying nothing looks original. Really? No originality? What about Voltorb or Electrode? Their Pokedex entries even say that they're Pokeballs. Diglett? Dugtrio? Over designed? What about Rhyhorn? I agree that each generation has its ups and downs, but not so much to where I cant hate any of them. I loved them all, and always will. Being a fan of ONLY the first generation doesn't make you a Pokemon fan, it makes you a fan of nostalgia.
I would say I am a purist to an extent ...
GEN1 holds a lot fo sentimentality, It gave the first concept of pokemon and sold it for soo many people
I have played later gens and didnt find that I wanted to play through them again
However I much prefer FireRed to the Original Red the updated graphics etc made it even more enjoyable
I also feel the amount of pokemon taht were added started getting a bit obscure..
In particular the legend/spirit/w.e pokemon and thing like the oen based on rubbish?
I did however enjoy Ruby quite a lot, and I like the viewpoint in black/white..
I'll always feel for me that the original is best, It was the seed that spawned so it cant be rivaled
But that doesnt mean i hate the rest of them.. haha
I'm not.
I got into Pokemon at Gen III, and so far Gen III, and V have been my favorites.
Gen I and FR/LG were the most boring Pokemon games I've played. There felt like there was a lot more to do and a lot more involvement with in the later generations. The only generation I didn't like was the new Pokemon and the anime oof D/P/Pt. It felt simple, easy, and very dumbed down for kids. I also felt the pokemon were an excuse for evolution and legendary concepts.
I don't think I am a Poke'mon purist because even though I have loved Poke'mon since the launch date but I still love the new ones they are making. (Every generation has the good and bad Poke'mon I personally think :) ) As you can see my favorite Poke'mon is Pachirisu so I am not a Poke'mon purist. =D
I really love first generation, and it's my favourite. But I'm not a purist.
I think any new generation won't make us dreaming as the first one did, because it was the very beginning of Pokémon. We all feel this awesome nostalgia when thinking of it. But that doesn't prevent us from liking the other generations !
Ok, for me first Pokémons were badass, that's for sure, but, there has been a lot of improvement since RBY, about the plot, the towns, so we can't say that 1st gen is the best of the best, just because it's the first. That doesn't mean that we can't prefer it, but let's be a little objective.
Pokémon ultra purists are too much stubborn.
first gen is my fav. and yes in my order it does go
gen 1 = 1st place
gen 2 = 2nd place
gen 3 = 3rd place
gen 4 = 4th place
gen 5 = 5th place
so yeah... but I'll agree that the story line in gen 1 was the most basic. I'll prefer playing fire red and leaf green to red and blue anyday though so I'm not sure if that makes me a gen one fan or kanto fan.
I don't see how anyone can argue that blue and red had the best graphics though :/
I wouldn't say I'm a Pokémon Purist. Why you may ask?
Well, each generation brings with it many different Pokémon. And within those Pokémon, some I love, some I hate, and some I just can't fathom why. It doesn't matter which generation it is or was, it's the same with each to me.
And example would be with Generation 1, I loved Dragonite, but I could not stand Weezing. In the current Generation, I can't stand Crustle, but I love the look of Krookodile.
I don't exactly fit your description of a Pokemon Purist but I think I'm kind of one? The first mon game I played was Ruby back when I was like 11, and to this day third Gen is still the best IMO. So I'm partial to my sentimentalities of my first Pokemon game, but it's not the first, "pure" generation.. I've still played a game from each generation though (well, if we can count HG as 2nd gen) which has allowed me to properly make my assessment.
i don't believe i'm one, personally. in the first place, i'm not even a huge fan of the first generation games (cue audience gasp). although, i've observed that my interest in pokemon has the tendency to decrease as the generations progress, but i don't necessarily believe that the earlier generations were the better ones.
This might shock some people who know me, considering they would know how much of a nostalgia nut I am, but I am not a purist. I do thoroughly love the Gen I games and pokemon, but not so much that it makes me think any less of the other gens. All of them have their own charms; 1 for being the original and starting off the great Pokemon adventure, 2 for having Typhlosion having Kanto and Johto, and having a fun-to-explore time skip, 3 for rehauling the internal mechanics and adding a whole bunch of new features, 4 for wi-fi and battle frontier, 5...I just started 5, so lemme get back to you on that. xD
But yeah, as you see, all the gens have their own things that make them fin, so I can't say I like Gen 1 more than any other for that reason. That said, purists have every right to be purists, so I just let them be.
I wouldn't really call myself a purist. Pretty much all the generations had at least a few pokemon that I pretty much hate.
Definitely not lol. I actually don't like how the Gen I games take a while to be immersed in it. The beginning areas (from Pallet Town to Mt. Moon) is just so boring... the later games feel more exciting (except FR/LG).
I'd say my favorite Generation so far is III.
One shouldn't fault anything merely for the sake of nostalgia. Granted, it's a common bias, but if you want to compare something truly, compare them as though you have never seen either before.
I am the farthest thing from a Pokemon Purist. I can understand them, but I would hope that they try to look at the newer generations with as little bias as possible.
I'm definitely not. xD;
Actually, Unova holds the record for favorite amount of Pokemon in a generation. In gen one, even though that was the original, and I was so enthralled with it before, there's only a handful or two of gen one Pokemon that I actually like. I found most of them weird, or unappealing in whatever ways. I enjoyed the story, and the anime more than the Pokemon themselves back then, and even the stories have been outdone by better games / anime seasons since then. So no, I'm not a purist.
And my opinion on them, is that I feel bad for them that they can't properly enjoy any of the newer games, since they can't shake them being just as fun, or better than the first gen games. Same goes for fans of the original anime, and etc. D: Maybe to them, gen one really is still the best, but I still feel bad that they're missing the joy of so many of the newer gens.
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DigitalFoundry- GTA IV Time-lapse: 15 Days in Liberty City
Spectacular time-lapse video from a multitude of locations within Liberty City, across 15 days of game-time.
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Destiny: King's Fall guide How to beat the tricky new Taken King raid.
Destiny: The Taken King guide Light level 290! PVP! Raiding!
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One lesson from Viet Nam that isn't popular during this neocon era is that invasion is only part of a military plan. A political plan for an exit is also vital. The US had no such plan going into Viet Nam or Iraq and was stuck both places longer than all of WWII. Israel withdrew from Gaza under Sharon without a political plan, too. So it is no wonder that it didn't bring about hoped for peace. If Israel wants to have the peace it hopes for, it must have some planning to accomplish peace. The question then becomes one of what the mission objectives would be in an invasion. And will those mission objectives last more than a month after an Israeli withdrawal? Unless Israel wants a forever occupation, it must have an exit plan.
Firebomb thrown during demonstration in northern Israeli town of Umm al Fahm (Haaretz)
from the article: A Vietnam called Gaza


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YstokCard - smart card API (PC/SC)(Modified)| YstokGrid(Modified)| CL-Typesetting(Modified)| CL-PDF(Modified)| Jean-Philippe Paradis(Added)| Armed Bear Common Lisp(Annotated)| Allegro Common Lisp(Modified)| CLFSWM - A(nother) Common Lisp FullScreen Window M...(Modified)| Ystok-URI - library for representing, parsing, and...(Added)| Clon, the Command-Line Options Nuker(Modified)| Common Lisp Reasoner(Modified)| ASDlite(Modified)| Ystok-Library(Modified)| Ystok-Local-Time(Modified)| YHTML-Template(Modified)| cl-gdata(Added)| Michael Filonenko(Added)| cl-portaudio(Added)| YstokHTML - collection of HTML generator, parser a...(Added)| Common Lisp User Space File System(Added)| cl-btree(Added)
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Submitted by admin 3581 days 3 hours 3 min ago
Comments added to RSS feeds
Now the commented items are added to the RSS feeds so that it's possible to see what have been commented recently.
Submitted by marc.battyani 3521 days 6 hours 53 min ago
unicode possibilities
It would be nice if cl-user would display unicode input for CJK text. With PCL and On Lisp getting new printings in Japan, it might be beneficial to attract more brain-share from that side of the world. Would this be considered out of cl-user.net's scope?
Submitted by charliemac 2617 days 38 min ago
Perhaps it would be interesting to open up a "universities" category (or subcategory of Organization) to list universities that teach lisp?
Submitted by informatimago 2609 days 15 hours 54 min ago
re: universities
This is a good idea. Done.
Submitted by marc.battyani 2606 days 20 hours 8 min ago
re: unicode possibilities
I have to think about it.
The use of English as the standard language is prefered so that the information is useable by most lispers.
I don't mind some other language content though.
Submitted by marc.battyani 2606 days 19 hours 40 min ago
Change descriptions may accept invalid characters
Attempting to view the "Last Modified Items" RSS feed in the Google Chrome browser gives the error: "error on line 10 at column 2048: PCDATA invalid Char value 12". Adding the feed in Mozilla Thunderbird: "<feed URL> is not a valid feed."
Submitted by WalterGR 1734 days 2 hours 39 min ago
Repository access
Many sites have a link to view the repository such as:
Source code repository http://common-lisp.net/cgi-bin/viewcvs.cgi/?cvsroot=cl-semantic
however, I can't find any place that describes how to convert that link into something that can be used to actually check out the source code. I'm very suppressed this hasn't been an issue before.
Submitted by blake1024 1368 days 15 hours 20 min ago


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"blue clouds" - it looks volcanic as tortured faces escape the land of Hades! ~:^0> Clouds, Volcanic Erupting, Erupting Volcanoes, Amazing Cloud, Blue Cloud, Mt Pinatubo, Philippines, Erupting Cloud, Mothers Natural
Awesome Design, Thai Carvings, Woods Carvings, Art Photography, Fractals Beautiful, Carvings Woods, Intricate Woods, Fractals And Spirals, Chiang Mai
Thai carving --This world is really awesome. The woman who make our chocolate think you're awesome, too. Our flavorful chocolate is organic and fair trade certified. We're Peruvian Chocolate. Order some today on Amazon! http://www.amazon.com/gp/product/B00725K254
Intricate Wood Carving in one of the restaurant in Chiang Mai which also features traditional Thai culture
carving wood.
Peahi, Maui, Hawaii Massive!!!!!!!
Dreams Home, Oahu Hawaii, Surfing Up, The Ocean, Reading Journals, North Shore, Big Waves, Maui Hawaii, The Waves
Darick Doener tow surfing big waves at North Shore, Oahu, Hawaii.
888-308-1817 to find your Hawaii dream home Ken Gines Realtor http://kengines.hawaiimoves.com http://schofieldbarracks.goarmyhomes.com @moving2hawaii #kenfucious
Surf's up! On the North shore of Oahu... the waves are awesome.
ACTIVATE/USE PRIOR KNOWLEDGE: What do you already know about this sport? Write your ideas in your reading journal. Day 3 Frindle
-Massive, Peahi, Maui, Hawaii, Tow-Surfing, surfers are taken out to the ocean (or towed) to surf these monstrous waves!
so cool
Little Girls, Travel Photo, Pure Joy, So Happy, Camels, Pictures, So Funny, Kid, Make Me Smile
re-pin, just because I love it so much! This little girl looks so happy, and the camel is funny too. dt
Pure Joy, this picture makes me smile everytime I see it.
Be happy... this is one oft all time favorite travel photos! #photography #camel #nomad #child #desert #sahara #bliss
This little girl and the camel just make me smile!
San Francisco California, Starry Night, Sanfrancisco, Photo Manipulation, Cities Skyline, The Cities, Places, Travel, Night Sky
So calming even with the hustle and bustle of the city
City skyline
San Francisco, California #SanFrancisco #California #Travel #Experience
San Francisco - I want to visit this place sooooo bad. I just love it.
Dreamlike Photo Manipulations of Earth and the Starry Night Sky Michael Zhang · Dec 28, 2011 For his project titled "Unrealistic Scenes", photographer Nathan Spotts composited his own landscape photographs with digital artwork of planets floating in the starry night sky.
Pongua Falls, Vietnam
Buckets Lists, Favorite Places, Pongour Fall, Beautiful, Pongua Fall, Vietnam, Travel, Photo, Natural
PONGUA FALLS, Vietnam. "Pongua Falls, also known as the seven layers waterfall, is such a beautiful, peaceful place that one day I came back for a third visit even though it was cold and raining. People often go there to walk and play in the falls so I thought I could get some nice photos. Then I saw the monks coming and rushed to a nice vantage on a rock outcropping where I clicked away as the monks chanted for a quick moment." (Photo by Dang Ngo)
Monks at Pongour Falls - Double click on the photo to Design Sell a #travel itinerary to #Vietnam at www.guidora.com
Beautiful. Pongua Falls, Vietnam. Bucket list
Pongua Falls, Vietnam <<< The beauty of Nature is amazing
starry night
Heart Aches, Dark Night, Starry Night, Black White, Cloud, Desktop Wallpapers, Broken Heart Quotes, Night Sky, Moon Pictures
Inspirational quote broken heart quotes Heart Ache Sadness Depression Breakup
night sky default moon picture and wallpaper
A starry night, with moon and clouds
dark night
seriously Stunning
Valley Girls, Young Women, Black White, Tribal Fusion, Photo, Africans Beautiful, World Culture, Eye, Young Girls
Mursi woman...I love black white and grays just beautiful
tribal fusion
gorgeous photo
african beauty
Stunning #world #cultures
Omo valley girl Etiopia
Psalms, Thunderstorms, God Beautiful, Lightning Storms Thunder, Luv Storms, Beautiful Lightning, Storms Cloud, Thunder Storms, Mothers Natural
"Your thunder was heard in the whilwind, you lightening lit up the world-" Psalm 77:18........that's a terrifying picture
Mother Nature
Storm Cloud.
I luv storms but I'd be running if I seen this!
Terrifyingly beautiful lightning
Gods beauty is beyond words...............
This photo intrigues me.
Like A Boss, Golden Eagles, Hunters, Men Cards, Funny Pictures, The Eagles, This Men, Riding Hors, Photo
This man is so effortlessly awesome. What a stunning photo!
Sunday 4 October 2015 | Ölgii - See one of the winning golden eagles on a live fox or wolf cub hunt, horse racing and a tug of war on horseback. After the festival meet one of the eagle hunters in their ger to learn more of this fascinating event and the Kazakh culture - http://www.abercrombiekent.com.au/mongolia/Itineraries/mongolias-golden-eagle-festival-an-ak-hosted.cfm
A Mongolian hunter on horseback with his Golden Eagle like a boss.
Luv this photo... Mongolian hunter on a horse with a golden eagle, via couleurlocale
man card is kept in my toolbox
Digital Infrared photography tips from expert Deborah Sandidge.
Frozen Trees, Winter Wardrobes, Infraredphotographi Infrar, Infraredphotographi Art, Trees Photography, Infrar Infraredphotographi, Winter Wonderland, Infrar Photography, Photography Trees
Frozen Tree
Infrared photography #infraredphotography #art #fine art
Infrared #InfraredPhotography #Infrared #Photography
Winters wardrobe
Infrared photography #trees #photography
blue clouds
Clouds, Volcanic Erupting, Erupting Volcanoes, Amazing Cloud, Blue Cloud, Mt Pinatubo, Philippines, Erupting Cloud, Mothers Natural
Volcanic Eruption - 1991 Eruption of Mt. Pinatubo, Philippines.
amazing clouds
1991, Eruption Cloud from Clark Air Base [Philippines] of the first major eruption of Mount Pinatubo
#Photo #Photography by Светлана Степанова
Black White Photography, Dreams, Black And White, Beautiful, Art, Random Thoughts, Storms, Mirror Images, Beaches Style
Life is always in motion. Although we can sometimes feel stuck, the universe is actually responding to the thoughts that we are thinking in every single moment. By simply changing our thoughts to match what we want, our life begins to change to reflect the changes in our thinking. Our life experience really is just a mirror image reflection of what we are thinking,
random thoughts
Stunning black and white photo.
After the storm
beach style
Lightning, Mothernatur, Awesome, Beautiful, Tornadoes, Storms, Photo, Extreme Weather, Mothers Natural
Extreme weather
couple gets married with storm in the background photos | It is not rare to see lightning storms near tornadoes.
Chattanooga Tornado - March 2012. In the words of Poison Ivy, "Never fool with mother nature!" Awesomely beautiful!!! THE TWISTED SISTERS; TENNESSEE TORNADO CHASERS!!! :-)))
Playground, Dreams Big, Swings, The View, Art, Pictures, The Cities, Photography, The World
Swinging with the city as my playground
Girl, Dream Big!
I just like the girl swinging over the city - the rest of the artwork is cool too - Located in Spain, Luis Beltrán is a 36 years old photographer. His creative fields are digital art, photomanipulation and photo illustration. His works have something with the dream, which makes them very poetic.
Wow what a fantastic picture. I love the view from this swing.
Swinging, high! #art #photography #artsy #masterpiece #creative #photo #snapshot #exposure #filters #moment #capture #keepitsimple #minimalism #minimal #simplicity #lessismore
The world is a playground, and life is pushing my swing. :)
It would be simple to edit a picture of someone swinging on top of a pic of the city
Charms, Beautiful, Children, Cafe, Baby, Kids, Portraits, Photography
The Doors, Little Girls, Doors Handles, Training Travel, Travel Tips, Training Riding, India, Photo, Feelings
Riding the train in Chittagong, Bangladesh, by Aftab Tuhin. I can feel the rush of the train. India photograph
Chittagong, Bangladesh. © Aftab Tuhin. A girl playfully hangs from the door handle of a train, in Chittagong, Bangladesh. September 23, 2006. Photo: Aftab Tuhin / Drik / Majority World
Train ride India
Little girl and her train ride in Bangladesh.
Train #travelling collections #travel guide #travel tips| http://travellingcollections613.blogspot.com
In Vogue
Vogue, Elephants Ears, April Shower, Alice In Wonderland, Black White, May Flower, Stripes, The Dresses, Photo
luv the dress, fab photo
striped dress and elephant ear
April showers, bring May flowers
Model wears Kate Madden striped cotton dress. Photographed by Peggy Sirota for Vogue Australia, December 1992. #vintagevogue
Black white spring. I'm in.
Vogue Australia like a scene from alice in wonderland
Paoloroversi, Fashion Photographers, Paolo Roversi, Italian Vogue, September 2004, Natalia Vodianova, Nataliavodianova, Fashion Photography, Singular Beautiful
Natalia Vodianova in A Girl of Singular Beauty for Vogue Italia, September 2004 Shot by Paolo Roversi Styled by Edward Enninful
#Russian #model #NataliaVodianova by #PaoloRoversi
#Natalia #Vodianova | Inspiration for #Editorial #Fashion #Photographer #Drew #Denny
A lone wanderer... a world away at Burning Man - photo from #treyratcliff at www.StuckInCustom... - all images Creative Commons Noncommercial
Photography Portfolio, Burning Baby, Burning Man, Trey Ratcliff, Treyratcliff, Burningman Festivals, Burning Men People, Hdr Photography, Men Festivals
Trey Ratcliff | Stuck In Customs | HDR Photography Portfolio
#105 #moments #exceptionnels #de #la #celebration #la #plus #psychedelique #au #monde, #le #fameux #Burning #Man #Festival
A lone wanderer... a world away at Burning Man - photo from #treyratcliff at www.StuckInCustom... - all images Creative Commons Noncommercial
☆ Burning Man ☆ #burningman #festival
burn baby.
The dark side
Hats, Velvet Dresses, Crowns, Color, Dark Beautiful, Red Velvet, Dark Side, Evil Queen, Happy Halloween
Love that the small hat looks like a crown in the wind
"Happy Halloween)"
Dark beauty.
Evil Queen
I love the hat, the colors, the edit. The tone. It' s all pulled together perfectly.
So hot.
Tattoo Ideas, Tattoo Women, Dragontattoo, Girls Tattoo, Backtattoo, Body Art, Full Back Tattoo, Dragon Tattoo Design, Tattoo Ink
female full back tattoos - Google Search
Dragon Tattoo #ink #Tattoo #Art
Asian body art
60 Dragon Tattoo Designs For Men and Women
I like this delicate dragon back tattoo #women #ink
newfashionmart.blogspot.com/2012/03/tattoos-design-for-gi... Tattoos Design for Girls, Tattoos for hot girls, Tattoos photo, Tattoos photos, New Tattoos Design, Tattoos for teen girls, Tattoos young girls, new Tattoos pictures, Tattoos design 2012, For people who love getting inked and want inspiration & tattoo ideas for their future tattoos.
by Igor Termenón
Great Hair, Cute Ideas, Antlers, Inspiration Photography, Photography Portraits, Sticks, Photoshoot Inspiration, Photo Shooting, Girls Hair
Cute idea
Photoshoot inspiration #photography #portrait
great hair!
I like stick antlers. I like them alot.
nice colors.


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I have a small strip (about 1-1 1/2 feet) in front of my brick house that needs to be separated from my front lawn. I would like to put bricks or something to keep the grass from coming through. What would you suggest to use to separate the two areas? What would you suggest to plant?
Rate This FAQ
I think the most effective lawn edging for that purpose is the plastic edging that comes in rolls. But there are many other materials that could be used: wood, metal, stone, brick or concrete will also work but cost varies and some last longer than others. It really depends on the "look" you want. The key is to make sure they are deep enough to prevent grass runners from entering your strip (usually about 6 inches). Plastic rolls and metal edging need to be staked to keep them in place.
As far as plants to use in your strip, that again depends on the look you want and how much work you are willing to put into it. Some gardeners love to putter and annual flowers would be nice because you can replace them frequently to provide seasonal changes in the appearance. Flowering perennials or small shrubs could be used, and once established they require less work. Keep in mind that 1 to 1-1/2 feet is not much space, so large shrubs should be avoided because their roots will need more space to maintain their health and vigor. Another thing to think about is exposure (what direction does the front of your house face?). Plants with a southern or western exposure will get more sun than plants with a northern or eastern exposure.
Some suggestions for perennials:
Salvia spp.
Gaillardia spp.
Rudbeckia fulgida
Liatris spicata
Part shade:
Hosta (mainly for foliage)
Polemonium (Jacob's ladder
Small shrubs:
Lavandula (lavender)
Mahonia (Oregon grape)
Berberis thunbergii (Japanese barberry)
Buxus koreana (Korean boxwood)
Good luck
Heidi Kratsch
Ornamental Horticulture Specialist
Submit Your Suggestion
Other Questions In This Topic
- What are the differences and advantages or disadvantages of soil amendments? Specifically Perlite (expanded silicous rock), Vermiculite (expanded mica), Utelite (expanded shale).
- I planted a spanish fir in my yard just two weeks ago. It appears to be dying. How often should I be watering it? And how much water should I be giving it each time that I water?
- We planted apple trees last year. When do we spray for cottling moths?
- Can you tell me how to get rid of the Star of Israel that is in your lawn?
- Many of my potatoes this year have splits in them, but then the skins have grown over the splits, leaving a very uneven skin. Is there something I have done wrong? We have watered about every 4-5 days.
- Do cottenless Cottonwood shed cotton after 7 to 10 years or are they always cottonless?
- We want to plant a couple of trees in our front yard that don't get very big (about 10 to 15 feet high). Can you suggest any are not messy and don't send up runners? If you have literature on selecting trees, could you send me a link?
- When should I cut back spent tulips and daffadills?


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Archives: October 2015
Randy Quaid Got Arrested While Trying To Cross The U.S. Border
No, that dog has nothing to do with this story. I just figured that if we had to look at Randy Quaid's greasy Santa-on-bath salts face, we should also get a cute fluffy doggie to cleanse our eyeballs with.
Two days after he was arrested by Canadian Border officials for being an immigration-dodging mess, Cousin Eddie has been arrested by American Border officials. I know, you totally didn't see this one coming, right? CBC News says Vermont State Troopers (please tell me it was Ramathorn and Womack) slapped Randy Quaid and his partner in crazy times, Evi Quaid, with a pair of handcuffs when they tried to slink across the U.S./Canadian border at 8pm last night. Yes, Randy was trying to flee Canada after he was deemed that he wasn't a flight risk. I guess Randy was trying to pull a "You can't deport me if I deport myself" power move or something.
Both Randy and Evi were detained and a judge has set their bail at $50,000 each. No word on why Evi was arrested as well, since she's not exactly the one up for deportation. But I'm sure there's probably some law on the books about skipping town with your husband who was specifically told to sit tight while they decided what day to send his ass back to California.
I have no idea why Randy and Evi couldn't just wait for Canada to tell them when it was time to pack their bags and GTFO. So impatient, those two! Personally, I would have stayed in Montreal as long as they would let me just so I could stuff my face with as many Montreal bagels as possible. Border security would need at least three of their strongest employees to drag my ass out. If you've ever had a Montreal bagel, you know what I'm talking about. It's like wood-fired poppy seed-covered crack. If I was about to be deported from the land of bagels, I'd run off to the nearest St-Viateur and eat till I shat circular bagel-shaped poops.
In the event you want to see the newest pictures for Randy and Evi's mug shot collection, they're after the cut.
Hot Sluts Of The Day!
I spent a piece of my Friday night watching one hit wonder videos from the 80s (as I usually do) and forty five pounds of potent glamour hit me right in the face when I landed on a music video from Bardeux. I barely remember Bardeux and I'm guessing that's because my brain wanted to protect me from overdosing on that much charisma, so it kept its memory of them to a minimum.
Bardeux first formed in 1988 and the first members of the duo were Stacy "Acacia" Smith and Tairrie B. They had a hit on the dance charts before Tairrie B quit that bitch and decided to go solo. (Tairrie B later became a rapper for a moment, so she's basically the original and better Iggy Azalea.) She was replaced by Lisa "Jaz" Teaney and that's truly when Bardeux shot up the charts and by that I mean they reached #36 on the Billboard Hot 100. They had a few dance hits, but their biggest hit of all-time was the freestyle slow jam "When We Kiss" and when you listen to it, you will wish that you were in the
champagne malt liquor room of some truck stop strip club giving a lap dance to a 78-year-old man. This is my kind of lap dance song and the video is a cinematic jewel filled with intrigue, sexiness and come hither lookers. It's like Stacey Q on Ambien:
Jaz left the duo in 1989 and Bardeux had several reincarnations before it died for good in 1995. But thank all the Gods for YouTube, because I would've been pissed if I died without reliving the glamour of Bardeux once again.
Birthday Sluts
Mario Lopez (42)
Aimee Teegarden (26)
Marina and the Diamonds (30)
Lzzy Hale (31)
Chiaki Kuriyama (31)
Cupid (33)
Una Healy of The Saturdays (34)
Mya (36)
Jodi Lyn O'Keefe (37)
Dale Earnhardt Jr. (41)
Brett Favre (46)
Wendi McLendon-Covey (46)
Bai Ling (49)
Martin Kemp (54)
Jodi Benson (54)
Eric Martin of Mr. Big (55)
Simon Townshend (55)
Julia Sweeney (56)
Bradley Whitford (56)
Tanya Tucker (57)
David Lee Roth (61)
Nora Roberts (65)
Jessica Harper (66)
Cyril Neville (67)
Ben Vereen (69)
Peter Coyote (74)
Pic: @MarioLopezExtra
Night Crumbs
The trailer for Hail, Caesar! starring George Clooney and everybody with an IMDB page is out. I already hate this movie. And only because when the early 90s ended, I thought I would never have to see George Clooney in a caesar cut again – Lainey Gossip
Tila Tequila is a cancer-curing, door-bending anti-vaxxer. How has Scientology not scooped her up and crowned her as their new leader and queen? – Starcasm
Meryl Streep is talking about feminism again… This almost makes me miss the words of wisdom from Matt Damon – Celebitchy
"I'm sorry, there's nothing we can do. The infection is too deep and too strong. We're going to have to amputate Lassie's tongue" – Drunken Stepfather
Charlie Sheen's ex-goddess used to be Kendall and Kylie Jenner's nanny. The jokes, they're too easy – The Superficial
Yolanda Foster's daughter and son also have Lyme disease – Reality Tea
I'm never crossing a bridge again – Towleroad
I actually like Kristen Stewart's weed socks and I'm typing this while sober – Popoholic
I'm surprised this crazy lady's car doesn't have Florida plates on it – Hollywood Tuna
Somebody asked Natalie Dormer how she feels about people saying she looks like Kermit the Frog's new piggy piece – Jezebel
In other words, Malcolm-Jamal Warner is mad that he's not getting those Cosby Show checks anymore – HuffPo
Three happy words: IT'S CAROL CHANNING! – Boy Culture
After smoking my 4th or 5th bowl, this is going to be me tonight – The Berry
Now we know that the Photoshop artiste who does Kim Kardashian's Instagram pictures also works for Victoria's Secret – SOW
FYI: Jared Leto is still dressing like a toddler at Burning Man – Popsugar
QUICK WEEKEND PROGRAMMING NOTE: Allison, our resident Canadian, is out on Sunday, because she's leading a DON'T DEPORT RANDY QUAID rally in the park. J. Harvey will fill in for her.
The CAPTION THIS Contest For October 9th!
Pic: Tosh.0
Shia LaBeouf Got Arrested For Being A Drunken Mess (UPDATE)
The last time I wrote about Shia LaBeouf, he had reportedly gotten into a messy, violent fight with his girlfriend at the time, Mia Goth, and it ended with him telling some dudes that he would've killed her. Well, Shia is still Shia'ing and he got busted in Austin, TX tonight for being all kinds of messy and not obeying the cops.
TMZ says that at around 7:45 tonight, Shia ran down Sixth Street while either drunk out of his mind or high out of his mind or both. I've been to Austin and I don't think anybody would ever blink an eye at seeing a hipster run down the street while drunk as hell. But Shia got busted when he jaywalked in front of the cops. The police told him not do it, but he did it anyway. The cops subdued his ass and arrested him. Shia is in town for Austin City Limits.
Shia spent a few months in rehab in 2014 after he pleaded guilty to disorderly conduct.
And if I had to say something positive, I'd say that at least this time Shia didn't keep anyone from seeing a half-shaked sweaty Alan Cumming shake that ass while singing show tunes. So there is that.
UPDATE: Shia was booked for misdemeanor public intoxication.
Pic: @Keslie_Rae
Stephenie Meyer Is Never Finishing That "Twilight" Spinoff Book And "Fifty Shades Of Grey" Is To Blame
After the Twilight series made Stephenie Meyer a millionaire many times over, she tried to squeeze more coins out of that shit by writing a spin-off book titled Midnight Sun. The spinoff book re-tells the first Twilight book from Edward Cullen's point of view instead of from the point of view of that dead-eyed Bella trick. Stephenie stopped writing Midnight Sun in 2008 when it was mysteriously leaked onto the Internet. She responded to the leak by releasing 12 unfinished chapters and said that she'll finish the rest once everyone forgets about it. But now Midnight Sun will never rise (don't worry, I hate myself for writing that too) and it's all E.L. James' fault!
Earlier this week, Stephenie Meyer farted up the news that she had re-written Twilight but gave Bella a peen and Edward a vampire vagina. She gender-swapped them. The Twihards rolled their eyes at that mess, because that's not the Twilight book they've been waiting for. They want Midnight Sun for some reason. According to Stephenie, that's never going to happen.
At New York Comic-Con, Stephenie told the room full of Twihards that after she finished the gender-swapped Twilight, she started working on Midnight Sun again. But the next day, she found out that she had been Single White Female'd once again by that copycat bitch E.L. James when it was announced that Grey was coming out. Grey is Fifty Shades of Shit as told from Christian Grey's perspective. E.L. James' snatched Stephenie's idea and put it out first. via Entertainment Weekly
"Midnight Sun is kind of cursed," she reportedly told the crowd. When 12 unfinished chapters of Midnight Sun leaked in 2008, Meyer said she was upset and put the project on hold. She said at the Comic-Con panel that she recently wrote a bit more from Edward's perspective. "What do you think was the top story on Yahoo the next morning?" she asked the crowd. "Grey."
"It was a literal flip the table moment for me," Meyer reportedly said. The book is still on hold.
A literal table flip? I can imagine all sorts of bizarre things, but I can't imagine Stephenie Meyer doing this:
"Plagiarist whoooor-ah!"
And there's really only one way to settle this. They must fight to the death! Actually, no, that's not a good idea. Because once they get into a room together, they made decide that their evil powers will strengthen if they join forces and that will lead to them shitting out a mash-up book called Fifty Shades of Twilight.
Pic: Splash
Tom Hiddleston Has An Elegant Way Of Talking About His Crazy Ass Fans
The craziest members of the Hiddlestoners have been accused of doing some insane shit like jumping on him at events, nearly trampling each other to get an autograph from him, following him home and on and on and on and on… ("Eh, is that all?" said a Cumberbitch before breaking into B. Cums' bedroom to rub their bare crotch on all of his unworn underwear.) Tom Hiddleston has said before that he's sick of being asked to take selfies and some of his fans can get obsessive by telling him that he's solely responsible for certain things that have happened to them in their lives. In other words, some are insane. During an interview with The Guardian to promote Crimson Peak, Tom was asked about his over-obsessed fans and he said these words of polite diplomatic poetry about the whole situation:
"[It's] an odd experience. But I won't be the first person to have thought that. I'm only in control of my own integrity. I'm accountable for everything I've done and I understand that. Everything else is out of my control."
That's either a polite way of saying, "Get some integrity too, you crazy bitches!" or it's a polite way of letting everyone know that he carries pepper spray and always has a stack of restraining orders in his jacket pocket.
Tumblr's favorite fap material continued to talk about integrity when he was asked about his public persona:
"I have tried with all my power for there not to be any inauthenticity. There is no version of me presented to you that's been created or is artificial. The people I've always respected have an integrity that is unassailable."
And he's so careful about his public persona that he's not going to talk about politics (take note, rest of Hollywood).
"I'm not in the business of being politically divisive. I don't want to set a precedent. It's a private matter. I believe in kindness. I believe very profoundly in that. I believe in bravery and courage, in being true to your word … Very unfashionable."
The Guardian's interviewer said that Tom was very careful with his words, because he knows the game and knows that there's a chance his quotes can be taken out of context. I feel that, because in this interview, he sounded like a cross between Jesus and the hero in a Disney movie. I don't know whether I want to lay at his Jesus sandals and listen to him talk about "integrity" or help him put his dragon-fighting armor on as he gives a speech about "bravery." Oh God, I hope that doesn't mean I'm turning into a fucking Hiddlestoner.
And here's Tom at the BFI London Film Festival premiere of High Rise with Elisabeth Moss and Sienna Miller who is wearing something that Marcia Brady would wear if she joined a cult in the 70s.
Pics: Wenn.com
Robert Downey Jr. Can Already Buy Us All, But Soon He'll Be Able To Buy Us All Twice
Usually steam rises up into Goopy Paltrow's parts. But after she finds out about Robert Downey Jr.'s pay raise, organic, filtered steam is going to shoot out of her ears, b-hole, mouth and everywhere else. Goopy is going to rage. Goopy recently spoke about the wage gap in Hollywood and she said this about how RDJ's salary:
"Look, nobody is worth the money that Robert Downey Jr. is worth. But if I told you the disparity, you would probably be surprised."
That wage gap is about to get a whole lot wider.
Forbes reported that last year, RDJ brought in $80 million and most of that money came from the back-end (wink wink) of Avengers: Age of Ultron. RDJ also reportedly got $40 million to play Iron Man again in Captain America: Civil War. Well, RDJ's going to need a much bigger checking account if Bleeding Cool is right.
Bleeding Cool says that the next two Avenger movies, Infinity War Part One and Two, will have a combined budget of $1 billion. $400 million of that $1 billion will be used to pay the main cast, director, producers and screenwriters. And of that $400 million, half of it will go into RDJ's cleavage, meaning he's going to make $200 million for both movies.
$200 million?!!!
Each of those Avengers movies will most likely make more than $1 billion each worldwide, but still. I agree with Goopy and I can't believe I typed that.
Since I have a gutter brain that's always thinking about man ass, my first thought was that he's getting paid $200 million and he doesn't even get naked in that shit. You know how in Working Girl when Joan Cusack is going through Sigourney Weaver's closet and she picks up a dress and says, "Six thousand dollars?! It's not even leather!" I used the same tone she used to say, "Two hundred million dollars?! He doesn't even get naked!"
But get money, RDJ. And congrats to his managers and agents who probably came their genitals off after they made that deal. The good news is that they're so rich that they can buy new genitals.
And here's Goopy Paltrow at LAX covering her face with a fancy purse that RDJ could buy with one of his solid gold boogers.
Open Post: Hosted By John Goodman
John Goodman is skinny, we've all seen Justin Bieber's dick and we can get an Egg McMuffin all day, every day. Everything in the world is different now.
For years, John Goodman has talked about his journey to SkinnyVille, and it all started when he gave up the sweet nectar in 2007. John once told David Letterman that he was 400 pounds at his biggest and thanks to putting healthier things in his mouth and exercising, the chunk has slowly melted off of his body and it keeps melting off. At last night's premiere of Trumbo at the BFI London Film Festival, a bunch of people asked, "Harpo, who dis skinny woman?", when a FUPA-less John Goodman strolled on by. A bunch of melodramatic people are saying shit like, "That's not John Goodman!" I still see John Goodman.
I loved Dan Conner when he was fat and I love Dan Conner now. But since 2015 is the year when our favorites say and do some fucked-up shit, I'm not going to be too surprised if I hear that he lost the weight after he sacrificed a litter of kittens to the devil.
And here's more of John Goodman with his co-stars Bryan Cranston and Dame Helen Mirren, who dressed up like a Who from Whoville going to a baby's christening.
Pics: Wenn.com


text:
The Botanist's Companion, Vol. II
or, An Introduction to the Knowledge of Practical Botany, and the Uses of Plants. Either Growing Wild in Great Britain, or Cultivated for the Puroses of Agriculture, Medicine, Rural Oeconomy, or the Arts., [en] 1816
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