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Top Dawg Ent.
Ab-Soul Almost Done With New "love story" Album
Ab-Soul fans, prepare yourselves. It seems like the wait for a new project may be coming to an end sooner rather than later. The TDE-repping Black Lip... Read More
Posted about 3 months ago by Brendan V
Featuring: Action Bronson | Ab-Soul | Elle Varner
Album: Lucky 7
Posted 3 months ago by DJ Z
Featuring: Aloe Blacc
Posted about 6 months ago by Brendan V
If Ab-Soul Got Dropped From TDE, What Label Should He Sign With?
Labels aren't what they use to be. Once upon a time they were seen as a rite of passage, a stamp of authenticity, proof that you made it to... Read More
Posted 7 months ago by Yoh
Posted 7 months ago by DJ Z
Posted 7 months ago by richard
Album: Tetsuo & Youth
Posted 8 months ago by richard
Featuring: Ab-Soul
Album: Champagne Water
Posted 11 months ago by richard
Featuring: Ab-Soul | Alex Wiley
Posted one year ago by richard
Posted one year ago by richard
Sample Text - Sample Link


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The Terraces
- Work 1-909-493-5929
- Rancho Cucamonga, CA
- 34.100711 -117.587537
Ironwood at Empire Lakes Apartment Homes
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5 Victoria Apartments For Rent
Rancho Cucamonga, CA
We found 5 apartments for rent in the Victoria neighborhood of Rancho Cucamonga, California. Refine your search by using the filter at the top of the page to view 1, 2 or 3+ bedroom apartments for rent in Victoria as well as cheap apartments, pet friendly apartments, apartments with utilities included and more. Use our customizable guide to refine your options for apartments in Victoria and find exactly what you want during your Rancho Cucamonga, California apartment search.
Madison Park Alta Loma10757 Lemon Ave. Rancho Cucamonga, CA 9173734.1374849 -117.57127+−Preview DetailsCollapse Details
Madison Park offers pet friendly one, 2 and three bedroom apartments in Rancho Cucamonga, Ca. Amenities include washer and dryer, wading pool and playground, as well as pool and spas.
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AMLI on Day Creek7828 Day Creek Blvd Rancho Cucamonga, CA 9173934.111104 -117.538574+−Preview DetailsCollapse Details
AMLI on Day Creek is located in the prestigious Victoria Arbors master planned setting across from Victoria Gardens Mall. Our Rancho Cucamonga upscale apartments are minutes from the LA/Ontario International Airport, the MetroLink, I-10, I-210 and I-15. With gorgeous views of the San Gabriel Mountains residents enjoy 20 parks, the community facilities as well as highly rated schools.
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Camino Real Apartment Homes7951 Etiwanda Ave. Rancho Cucamonga, CA 9173934.108781 -117.52367+−Preview DetailsCollapse Details
Crowned by the beautiful San Gabriel Mountains and steeped in rich vineyards, Camino Real offers premier Southern California apartments just moments away from Rancho Cucamongas city center. We offer one, two and three bedroom, pet friendly apartments in Rancho Cucamonga, Ca.
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Sierra Heights10801 Lemon Ave. Alta Loma, CA 9173734.139725 -117.568355- Near Rancho Cucamonga, CA+−Preview DetailsCollapse Details
Pet friendly one, two and three apartments in Alta Loma, Ca. Sierra Heights offers amenities such as sports courts, a children's play area and picnic area, as well as 24 hour courtesy patrol.
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AMLI at Victoria Arbors
7922 Day Creek Blvd | Rancho Cucamonga, CA See Other AMLI Residential Communities
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subset: commoncrawl


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about Todd FlowerdayA Roman Catholic lay person, married (since 1996), with one adopted child (since 2001). I serve a parish in music ministry.
about John Donaghy
John is a lay missionary since 2007 with a parish in western Honduras. Before that he served in campus ministry and social justice ministry in Iowa. His ministry blog is http://hermanojuancito.blogspot.com
He also blogs reflections on the lectionary and saints/heroes/events of the date at http://walktheway.wordpress.com
He'll be a long-term contributor here analyzing the Latin American bishops' document from their 2007 Aparecida Conference.
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Daily Archives: 12 March 2013
Gloria Sends Cardinals To Conclave
Liam sent me an e-mail noting that the Conclave opening Mass sang the Gloria. I wasn't terribly surprised. With MR3, it's not so much about elevating the cardinals to the level of Saint Joseph (19 March) or the Blessed Mother … Continue reading
Posted in Liturgy Tagged church music, conclave, liturgy 2 Comments
Someone should cover the mothers (and other family members) of the papabile more carefully. Quote of the day from Eleonore Schönborn: Christoph would not be up to the bitchiness in the Vatican. The intrigues in Vienna are enough for him.


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Readings — From the November 2004 issue
By Alex Beels (Translator)
This article is available in PDF and Read Online formats only.
By J. M. Coetzee
By Randall Kennedy
By Ted Conover
By Virginia Sole-Smith
© 2015 Harper's Magazine Foundation. October 2015 cover: Monitors inside the Lincoln Memorial protecting the leaders of the March on Washington, August 28, 1963 © Dan Budnik


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Kasba Tadla, Morocco News
Local news for Kasba Tadla, Morocco continually updated from thousands of sources on the web.
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Which of These Australianisms Do YOU know, Ya Drongo?
17 Razzie-Nominated Performances That Were Actually Kind of Amazing
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18 Cancelled TV Shows That Ended on an Unresolved Cliffhanger You'll NEVER Get Over
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Michael and JuliAn Domke are missionaries among IMB personnel who received an unexpected offer Sept. 10 to take early retirement by the end of the year. The Voluntary Retirement Incentive is the first step in a plan recently announced by president, David Platt, to resolve the organization's financial troubles.
The Greater Toronto Area boasts a population of more than six million, including people from 200 ethnic groups speaking 160 languages. The North American Mission Board's Send initiative in Toronto is working hard to recruit N.C. churches to join their team, and step up to the plate of missions engagement.
The long battle to reauthorize the United Stations Commission on International Religious Freedom (USCIRF) appears to be nearing an end. On Sept. 30 the U.S. Senate passed a four-year reauthorization that largely maintains USCIRF's current structure and direction. The legislation funds USCIRF at $3.5 million annually and is deficit neutral.
Iranian President Hassan Rouhani Sept. 30 declined to meet with the wife of imprisoned American pastor Saeed Abedini during his trip to the United Nations, days after the Christian's wife learned her husband had recently been tortured. Naghmeh Abedini said the Iranian government is treating him "like a pawn in a game of chess."
Representatives of diverse faith groups have called on President Barack Obama to press Xi Jinping on religious and other human rights issues during the Chinese president's visit to the United States capital. Xi will be in Washington for a White House state visit Sept. 24 and Sept. 25.
Patras is sometimes called the Gateway to Western Europe. But for hundreds of refugees already here, it's a nightmare. They live in an intermediate state – a purgatory with no clear means of escape or end. They had hoped to travel to Italy by boat or ferry, but ...
Evelyn Harthcock never met a stranger. She was "mama" to many and her Southern drawl, hospitality and her deep love for people transcended language and culture. The 94-year-old emeritus IMB missionary died on Sept., 18, 2015, after a battle with Alzheimer's. Although she officially retired from the IMB, she never "retired" as a missionary.
In preparation for the Rugby World Cup 2015, churches in England are asking for prayer as they prepare to share the gospel with hundreds of thousands of rugby spectators. From Sept. 18 to Oct. 31, 11 cities across England and Wales will host 48 tournament matches played by 20 teams from around the world.
Naghmeh Abedini, wife of imprisoned American pastor Saeed Abedini, is on a 21-day "Daniel" fast and is organizing prayer vigils internationally Sept. 26, the third anniversary of her husband's imprisonment in Iran for his Christian faith. She is also is promoting a letter-writing campaign ...
The chairman of the U.S. Senate Foreign Relations Committee, Sen. Bob Corker, R-Tenn., has expressed his agreement with a Southern Baptist Convention resolution's condemnation of "religious persecution and human rights violations in North Korea." SBC messengers "appeal[ed] to [dictator] Kim Jong Un and the government of North Korea ...


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|Sep 29 2015
|Politique Diabolique
|Sep 11 2015
His destruction was indicative of the fact that the communist witch hunts which had begun in Washington, D.C. had by 1951 spread into every sector of society—the entertainment industry, the professional ranks, labor unions, and black communities such as Watts, Harlem, and Oakland. It was a disgraceful period in U.S. history. Consider—many other countries, particularly those in Europe, lived up to their democratic ideals by allowing communist parties to have a voice in the political discourse. But given free reign to disseminate their solutions, communists didn't then and haven't since had great success convincing significant numbers of voters to follow their path. In the U.S., by contrast, top political powers decided that Americans could not be allowed to hear such ideas at all. Thus the anti-democratic red squads were conceived and over the next two decades ruined thousands of careers and lives.
|The Naked City
|Aug 2 2015
The above photos are interesting examples of the editorial focus of the Los Angeles Examiner during the 1950s. Pretty much anything that crashed, burned, bled, or exploded made it into the paper. In this case, a motorist going east on Ramona Boulevard lost control of his car, struck the median, and careened through a chain link fence onto the railroad tracks flanking the road. The spectators are eyeing the scene from the Herbert Avenue overpass. This happened today in 1951.
|The Naked City
|Jul 14 2015
The photo above shows the path an unfortunate named George Yasbec took when he leaped from the Municipal Courts Building in Los Angeles today in 1952. He was distraught over a drunk driving conviction. We've shared press and police photo diagrams in the past, and below you'll see several more, all for leapers—including the uncollected bodies of several—in the Los Angeles area during the 1950s.
|The Naked City
|May 9 2015
A dismayed but dapper narcotics suspect named Walter Collins gets a double grilling from two LAPD detectives as they sort through a stash of contraband pharma. Collins looks like he's got a headache, which may very well be true considering the circumstances, but of course he's actually hiding from the intrusive Los Angeles Examiner photographer documenting his downfall. The photos were made today in 1952.
|The Naked City
|Apr 16 2015
|The Naked City
|Mar 24 2015
Above and below is a fascinating series of photos from the Los Angeles Examiner during the heyday of tabloids, showing just how invasive such publications could be. The photo above shows the aftermath of a murder-suicide at the Ansonia Apartments in L.A.'s MacArthur Park neighborhood. A mother jumped from a window with her six-year-old son. The photos below show the scene from different angles, then a priest administering last rites to the boy, and finally the father grieving over his son's body. The Examiner focused on crime, corruption, and Hollywood scandals, and was for a time the most widely circulated newspaper in Los Angeles. Possibly its most famous scoop was breaking the story of the 1947 mutilation murder of Elizabeth Short, better known as the Black Dahlia.
In the references we dug up on the Clouart tragedy the wife's name is never given—she's called only Mrs. Gerald Clouart. That was of course common practice at the time, but it's ironic the way it renders invisible a woman who might have received help had anyone truly discerned her troubles. But in yet another example of the Examiner's extraordinary access, one of its photos is of Mrs. Clouart's suicide note, and we were able to get her name from that. The note said: "I've reached the point of no return. It's not your fault. You've been a wonderful husband and father. Am taking [John] with me to spare him the disgrace. I'm just inadequate." It was signed Terry. That was today in 1952.
|Intl. Notebook
|Feb 4 2015
Los Angeles has always been a place where gaudy signage and programmatic architecture reigns, so when a real estate company decided in 1923 to erect a giant Hollywoodland sign on Mount Lee to publicize a chic housing development in Beachwood Canyon people hardly blinked an eye. In 1944, the development's owners deeded the sign to the city, which by then had begun to symbolize the motion picture industry. In 1949 a storm blew down the H, and with the sign now reading "ollywoodland" debate took place about whether to demolish the rest. But the Hollywood Chamber of Commerce ponied up $5,000, contracted the Department of Parks and Recreation to repair the H and, while they were at it, take down the L-A-N-D, thus matching the landmark to the name of the city it promoted, resulting in the sign's current, world famous form. Above and below you see a collection of photos made from the time of the Hollywood Chamber of Commerce's makeover and before. The sign is very small in some of the shots, but it's there.
|The Naked City
|Jan 20 2015
This photo made today in 1959 shows a woman named Jessie Mae Noah, who Los Angeles police had arrested and were questioning in connection to a crime that had occurred seven weeks earlier. On that December night a Samuel Goldwyn Studios suit named Kenneth Savoy walked into the In Between Café on Melrose Avenue during the time two men—one holding a sawed-off shotgun—were in the process of robbing it. Having collected the money and valuables of eight patrons and the contents of the cash register, they demanded Savoy's wallet, and perhaps having watched too many of his own movies, he replied that if they wanted it they'd have to shoot him. That hard-boiled response earned him a load of buckshot in the stomach. The robbers scampered to their getaway car—where Jessie Mae Noah was waiting in the rear seat—and fled the scene.
After police published composite sketches of the robbers in the newspapers, Noah contacted police, resulting in the photo op above. The robbers—George Scott and Curtis Lichtenwalter—were arrested later (for those who wonder whether composite sketches ever work, check the comparison between Scott and his likeness at bottom).
Scott had fled all the way to Texarkana, Arkansas, and gave up only after a shoot-out with police at a motel. Jessie Mae Noah claimed she'd had no idea her two acquaintances were planning a robbery, and that she had simply gone for a ride with them for kicks. She avoided a murder charge, but Scott and Lichenwalter were both found guilty of robbery and first degree homicide. Scott—the triggerman—was gassed to death by the state of California in September 1960. And as for the victim Kenneth Savoy, you have to wonder what he thought in that instant when the shotgun went off. We suspect he thought that maybe calling bluffs was something best left to the stars of action films.
|Jan 8 2015
The above photos show Barbara Burns when she was busted for drugs today in 1958 after LAPD officers found track marks on her arms. Burns was the well-to-do daughter of famed comedian Bob Burns, but her father had died of kidney cancer in 1956. Barbara Burns was sentenced to probation after the arrest, and the story got some play in national newspaper, with several calling her probation sentence a storybook opportunity at a second chance. But she didn't cooperate in the role. She managed to cobble together some behind-the-cameras television work, but was arrested for heroin possession in 1959. That time she served ninety days in jail and admitted in an interview, "I'm really hooked. I had nothing else to do, and my mother wouldn't talk to me. I wanted to be a singer but I was too heavy and they told me it would help me lose weight."


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November 5, 2013
Would like to meet fellow like minded Russians
Social gatherings, someplace that facilitates good food and good conversation.
I would like to expand my circle of Russian speaking friends.
Live in Philly and work for a CC LGBT org, would love to meet fellow Russians.
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Queens Library's Older Adult Services Program is proud to present Older Adults Day, which will feature live entertainment, programs, and short presentations on a variety of topics specifically for older adults.
In addition to special events and activities, there will be 20 organizations present at Older Adults ...
Every Tuesday, Queens Library will introduce you to a great new book!
Our pick for #BookTuesday, October 6 is Two Years Eight Months and Twenty-Eight Nights by Salman Rushdie.
In the near future, after a storm strikes New York City, the strangeness begins. A down-to-earth ...
This past June, Astoria resident and Queens native Maria Lisella became the borough's new Poet Laureate. Maria will be joining us at Central Library on Sunday, October 11 at 2:00 p.m. for our Open Mic for Poets.
Maria is the author of three books of poetry, including the recently published ...
Would you like to learn more about planning for your retirement and financial future? If so, come join us at one of our many Elder Law Seminars (free of charge), where you can learn valuable information about financial planning for yourself and your loved ones.
A specialized attorney will be discussing various ...
Get the Tools You Need to Launch Your Own Business and Enter a Contest to Win $10,000 in Seed Funding!
The mandatory training sessions for the 10th Annual StartUP! Compettion begin in October. All participants must complete a session on each of the four training topics.
All live training sessions are ...
Mail-A-Book continues to enrich the lives of the homebound with both new and traditional ways to communicate with its customers!
Queens Library's Mail-a-Book Service offers customers the convenience of having library materials delivered to their door free of charge. These materials include books in large print, regular ...
Discover the magic of the Lincoln Center for the Performing Arts in your neighborhood! Queens Library has partnered with Lincoln Center to bring FREE events to a library near you.
Lincoln Center Local offers live hour-long programs combining performance with a question-and-answer session in a dynamic, first-hand encounter with ...
Looking for new music? Look no further than your local Queens Library!
Every month, our expert staff will bring you the best of what's new in our physical and digital collections.
This month features music from The Weeknd, Vince Staples, Courtney Barnett, Hilary Duff, NF, the New Hanover Public Library Rap Club, Elvis ...
Queens Library is partnering with Asia Society to bring some of its award-winning programs directly to library patrons in Queens. This collaboration will showcase current events and cultural changes, and introduce new, perhaps little-known, aspects of Asia to the residents of Queens—the most ethnically diverse urban area in the ...
Book Discussion Group
Location: Middle Village
Registration: Not required
The book selection for this month is "The Invention of Wings" by Sue Monk Kidd. Pick up a copy at the Information Desk and join us!
Broadway Showstoppers
Location: Middle Village
Registration: Not required
Vocalist Naomi Zeitlin belts out great music from the Broadway stage. Enjoy selections such as "Send In the Clowns," "Don't Rain On My Parade," "All That Jazz," "I Dreamed A Dream," "Losing My Mind," "Cabaret," and more.
Book Discussion Group
Location: Middle Village
Registration: Not required
Set in the 1880s, Jennifer Donnelly's "The Tea Rose" is a riveting historical epic about a young woman who flees East London and an unscrupulous tea merchant to reshape her destiny and reclaim her past in New York City. Pick up a copy at the Information Desk and join us!


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The settlers who once led the camp have been pushed aside in favor of the wisdom of the masses, who want an immediate and violent solution.12:23 06.10.15 | 5 comments
Peretz needs to understand the media is not harassing him. What they are saying is the Winograd report showed he didn't have a clue to whats happening. Proof is the picture of Peretz looking thru binoculars with the lens cap on. What he saw then shows he didn't have a clue to what he helped Israel get involved in. He was a total failure and needs to resing his position. He needs to show he has some class and leave on his own accord. I believe Israeli's are not goi ng to let this die with out their removal from office


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Posted on 15 May 2014
- 09:58
Former players from Spurs, Arsenal, Chelsea and West Ham will do battle at the F30 Legends event – being held at Leyton Orient's Matchroom Stadium on Sunday afternoon from 12pm.
The tournament comprises 30-minute matches and organisers have lined up a host of well-known former players who have previously represented all four clubs to take part.
2 September 2015
Tottenham Hotspur Foundation hosted the fourth Godwin Lawson Memorial Tournament which took the form of a girls-only tournament this year, held at Frederick Knight Sports Centre.
18 May 2015
Around 400 young hopefuls from across the country will get a unique chance to represent their local Premier League club on the hallowed turf at White Hart Lane on Thursday, May 21.
13 May 2015
The Spurs Legends team will be in action at Leyton Orient's Matchroom Stadium this Sunday (May 17).
View mobile site
© Tottenham Hotspur Ltd 2015. All rights reserved.
All photography copyright Getty Images (unless otherwise stated)


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Having stayed at this property before, felt like it was ok , as not alot of hotels in the area. Bed good and rates ok. Rooms need updating . Breakfast ususal offerings. ( sorry the coffee not too good). Would stay again though,
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*Just like the headline says, this page/board is where you can discuss the stuff that we didn't cover in today's issue. (It's sort of like feedback with a twist) Remember, NO name calling, racial taunting, graphic sex talk and vulgarity in general, PLEASE.
Life is very short and what we have to do must be done in the now. – Audre Lorde
June 21: Producer/rapper Pete Rock is 43.
June 21, 1923: Marcus Garvey was sentenced to five years in prison after his conviction on charges of using the mail to defraud. Garvey said the charges were political. (Source: www.BlackFacts.com)
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TV SpecialAlternate Title: American Experience (02/03/97)
More in Television
TV Highlights
What's On This Week
A daily updated summary of the week in TV.
Program Overview
Executive Producer: Margaret Drain
Genres: Documentary, Historical
Genres: Documentary, Historical
Program Synopsis
Documentary about the invention of the telephone and how it quickly was transformed from novelty into necessity at the turn of the 20th century.
What's On Tonight
- Vigée Le Brun: A Delayed Tribute to a French Trailblazer
- Review: Hillary Clinton on 'Saturday Night Live'
- Wilton Felder, Saxophonist for the Crusaders, Dies at 75
- The Tower That Enchanted Yeats
- Art Review: Hope and Dread Are Infused in 'Berlin Metropolis'
- With 'Divers,' Joanna Newsom Is Clinging to Her Every Word
- Review: 'Il Trovatore' and 'Anna Bolena' Showcase Courage and Command at the Met
- Art Review: A Lesser-Known Modernism Inspired by African-American Culture
- Carnegie Hall Faces Internal Strife Ahead of Anniversary Season
- Pete Davidson Nuzzles Up to the Prickly Joke


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Still in good condition
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Zaandam Cruise Review by chunkylover43: Whales and Eagles! Oh my!
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Whales and Eagles! Oh my!
We had heard that the quality of HAL was diminishing but such was not the case on our seven day cruise to Alaska. Service is still top notch and unobtrusive. Food quality is still very good. Holland America offers good, consistent value for your money.
Published 06/04/09
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West Texas Intermediate for November delivery rose 86 cents, or 1.9 percent, to $47.12 a barrel at 9:48 a.m. on the New York Mercantile Exchange.
West Texas Intermediate for November delivery rose 86 cents, or 1.9 percent, to $47.12 a barrel at 9:48 a.m. on the New York Mercantile Exchange.
Schlumberger reveals new plans for U.S. headquarters
The oil and gas company, currently based at 5599 San Felipe in Houston, plans to expand its existing offices in a southwest suburb.
Texas power company delays debt payments as it weighs bankruptcy
Energy Future Holdings said it took a month-long extension on more than $100 million in debt payments due Tuesday as it plans in a possible bankruptcy restructuring with its stakeholders.
Oil falls below $100 on China factory data
The price of oil fell Tuesday, dented by soft Chinese manufacturing figures and Russia's withdrawal of a small number of troops from the forces massed along its border with Ukraine.
Texas producing 36 percent of US crude
More than one of every three barrels of U.S. crude is pumped in Texas, according to the latest monthly figures from the federal Energy Information Administration.
Workers injured as blast rocks Washington gas plant
A large explosion rocked a natural gas processing plant on the Washington-Oregon border Monday, injuring five workers.
Feds confront industry skepticism on new safety hotline
Federal regulators are pleading with the oil industry to 'fess up when they dodge accidents at offshore production platforms, rigs and drillships.
Gazprom raises gas export price as Ukraine looks for cash
Russia's natural-gas export monopoly raised prices for Ukraine 44 percent after a discount deal expired, heaping financial pressure on the government in Kiev as it negotiates international bailouts.
Energy industry targeting carbon to clean up business
Buoyed by gas, the fossil-fuel industry is trying to bask in a newfound green image.


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Socialist Youth Union of Sri Lanka to commemorate struggle against dictatorial rule on Valentine's Day
Tue, Feb 12, 2013, 08:20 pm SL Time, ColomboPage News Desk, Sri Lanka.
Feb 12, Colombo: Socialist Youth Union, affiliated to Sri Lanka's Marxist party Janatha Vimukthi Peramuna (JVP) says that Valentine's Day is to commemorate the struggle by Saint Valentine, who carried out a struggle against the dictatorial, cruel rule at the time.
National Organizer of the Union, Bimal Ratnayake told a news conference today that the Socialist Youth Union will launch a campaign on the Valentine's Day on the 14th to promote a love that does not believe in caste, creed or dowry.
He observed that the Valentine's Day that commenced to mark a struggle against oppression has now been commercialized.
"As the SYU we thought of having a dialogue regarding the obstacles that exist in this country for love and to show our youth how to overcome those obstacles," he said.
According to Ratnayake, the real significance of Valentine's Day should be given prominence and it should be made meaningful to the country's youth.
"It is a day to commemorate a courageous priest who fought against a cruel ruler against injustice to the youth. It should not be made a day to sell goods," he added.
ColomboPage - Recent 10 Stories
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Sri Lankan government to resolve tea estate workers' wages issue
Sri Lanka, Japan discuss upgrading bilateral relations during PM's visit
Former minister Karuna denies allegations against him in the UN report
Mega Twin Tower Condo project Luxe Residencies launched by Home Lands Skyline
Sri Lanka sends a CID team to Maldives to assist investigations on president's boat explosion


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Browse our archive of previous weekly NEWSLETTERS
OFFICE: - Twice weekly reports & charts, Mondays,
Thursdays (after 4pm).
NEWS: - Gossip free zone.....
* Friendly and foodie BOFA;
* Animation from Pakistan in Indian filmfest;
* Shadow of Doubt features at Lorne filmfest;
* Aussie summer = Moonlight Cinema;
* Canberra filmfest 'not standard fare';
* Have you heard the one about … The Heckler;
* Ross Hannaford on DVD thanks Haydn Keenan;
* The widow and The Telegram Ma win at Cause filmfest;
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Preview trailers of many films on your own screen.
The Lobster, stars Colin Farrell, Rachel Weisz;
He Named Me Malala, documentary by Davis Guggenheim;
Sleeping with Other People, stars Jason Sudeikis, Alison Brie;
The Intern, stars Robert De Niro, Anne Hathaway;
Spotlight, stars Michael Keaton, Mark Ruffalo, Rachel McAdams;
Freeheld, stars Julianne Moore, Ellen Page, Michael Shannon;
Spectre, stars Daniel Craig, Christoph Waltz, Monica Belluci;
Alejandro Gonzalez Inarritu's The Revenant, stars Leonardo DiCaprio, Tom Hardy;
Bridge of Spies, stars Tom Hanks;
Rock the Kasbah, stars Bill Murray, Bruce Willis, Kate Hudson;
The Walk, , stars Joseph Gordon-Levitt, Ben Kingsley;
The Martian, stars Matt Damon, Jessica Chastain;
Man Up, stars Lake Bell, Simon Pegg;
Star Wars: The Force Awakens, stars Harrison Ford, Mark Hamill, Carrie Fisher;
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SPY – Stars Melissa McCarthy, Jason Statham, Jude Law, Rose Byrne. "It's spoof, comedy and action all bundled together in one delicious entertainment package helmed by Bridesmaid's Paul Feig, its splendid cast lassoed together by Melissa McCarthy in her best role yet," says Louise.
Every Australian film we have ever reviewed (film / video release), or have reported from the set, or featured in any way, is listed here, going back to films made even before the launch of Urban Cinefile, such as The Piano, Romper Stomper, Muriel's Wedding, The Adventures of Priscilla Queen of the Desert and dozens more. Approximately 500 films AUSTRALIAN FILMS


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July Summer/Winter Sale »
Fiction » Literature » Literary
Boss Gull by Barry Klemm
Price: Free! Words: 100,370. Language: Australian English. Published: November 8, 2013. Categories: Fiction » Literature » Literary(5.00 from 1 review)
Two Hard Men Friends for Life Enemies to the Death! WWII buddies and bonded by a tragic event, Frank and Lyle remain friends even though Frank goes up and up while Lyle remains at the bottom. Until the day when Frank decides he's rich and powerful enough to take on his oldest friend. But Lyle is the only man Frank was never afraid of; something of which he is about to be devastatingly reminded.
Weeks in Naviras by Chris Wimpress
Price: $2.99 USD. Words: 116,550. Language: British English. Published: November 1, 2013. Categories: Fiction » Science fiction » Utopias & dystopias, Fiction » Literature » Literary
Something is wrong at the heart of the tiny fishing village of Naviras, a place where Ellie often sought refuge as her husband's political power grew. Ellie has returned to Naviras just as a conspiracy to destabilise the Middle East is erupting. The village is the first and last place she ought to be, but Naviras has saved its biggest and deadliest secret for last.
Three Miles Square by Paul Corey
Price: $4.99 USD. Words: 138,470. Language: English. Published: October 25, 2013 by Foreverland Press. Categories: Fiction » Literature » Literary, Fiction » Classics
A captivating story that is the first volume in what has become known as the "Mantz trilogy," Three Miles Square garnered glowing reviews from some of the nation's luminary mid-twentieth century intellectuals when it was first published in 1939.
Ghost Town by Catriona Troth
Price: $3.91 USD. Words: 127,060. Language: British English. Published: October 25, 2013. Categories: Fiction » Literature » Literary, Fiction » Cultural & ethnic themes » Cultural interest, general
1981. Coventry, city of Two Tone and Ska, is riven with battles between skinheads and young Asians. Photographer Baz—'too Paki to be white, too gora to be desi'—is capturing the conflict on film. Unemployed graduate Maia—serial champion of liberal causes—is pregnant with a mixed-race child. Neither can afford to let the racists win. They must take a stand. A stand that will cost lives.
Cities of the Interior by Anais Nin
Price: $9.99 USD. Words: 198,030. Language: English. Published: October 21, 2013 by Sky Blue Press. Categories: Fiction » Literature » Literary
Cities of the Interior is a collection of Anais Nin's five major novels, Ladders to Fire, Children of the Albatross, The Four-Chambered Heart, A Spy in the House of Love, and Seduction of the Minotaur. Written in modernist prose, Cities explores the psychological and sexual dramas lived out by their fractured characters, each of whom seek to become whole through their experiences.
The Accidental Peacemaker by George Lindamood
Price: $9.99 USD. Words: 159,810. Language: English. Published: October 19, 2013. Categories: Fiction » Literature » Religious, Fiction » Literature » Literary
This is a novel about the second half of life and how one might deal with the predictable, if not inevitable crises: divorce, downsizing, depression, discouragement, and denial. In a sense it is a stealth self-help book, but rather than preach rigid doctrines and disciplines, it attempts to teach the reader through suggestion, explanation, and example, all packaged in a heart-felt story.
Boundless by Brad Cotton
Price: $3.99 USD. Words: 106,450. Language: English. Published: October 16, 2013. Categories: Fiction » Literature » Literary
Is it possible to leave everything behind and start your life over again? Twenty-something friends Duncan and Ray take off on the road to determine just that. Leaving Phoenix and heading east, their only plan is to not have a plan at all — until, real life catches up with them.
Darshan by Amrit Chima
Price: $4.99 USD. Words: 145,600. Language: English. Published: October 1, 2013. Categories: Fiction » Historical » General, Fiction » Literature » Literary
Darshan chronicles the story of a family's 100-year journey across continents to escape a crime that haunts them through generations. "A multigenerational family epic in every sense of the term: nuanced, thoughtful, well-written, and deftly mixing history with fiction." -IndieReader
Book of Days by Charles Bechtel
Price: $4.99 USD. Words: 113,230. Language: English. Published: September 28, 2013. Categories: Fiction » Literature » Literary
Travel a man's life through twelve chapters, each chapter the length and breadth of a day. Claude is a boy who wanted to draw, a youth who had much to see, and a man compelled to put himself and those around him onto a canvas. The twelve days visited invite a reader to inhabit this person, who sought only to find honesty and permanence among those who touched him, and within himself.
Little Boy by Anthony Prato
Price: $0.99 USD. Words: 101,630. Language: English. Published: September 26, 2013. Categories: Fiction » Literature » Literary
A.J. dreams of graduating high school and entering the U.S. Air Force Academy. But when he falls in love with Maria, his life is changed forever.
The Last Hour by Charles Sheehan-Miles
Series: Thompson Sisters, Book 4. Price: $5.99 USD. Words: 138,880. Language: English. Published: September 21, 2013 by Cincinnatus Press. Categories: Fiction » Literature » Literary, Fiction » Women's fiction » General
Carrie Thompson-Sherman's charmed life begins to unravel as a jealous colleague puts her fellowship in jeopardy and a hideous secret Ray carried home from Afghanistan comes to light. Hanging on by a single thread, a disastrous accident puts both her husband and her sister's lives at risk. Heartbroken, Carrie will be faced with the most devastating choice of her life.
Black Wine by Candas Jane Dorsey
Price: $4.99 USD. Words: 106,370. Language: English. Published: September 17, 2013 by Five Rivers Publishing email@example.com. Categories: Fiction » Literature » Literary, Fiction » Science fiction » General
Winner of the James Tiptree, Jr. Award, Crawford Award, and Prix Aurora Award. An old woman hangs in a cage; a young woman slaves on a rich lord's estate. How does a woman discover and assert her identity in a primeval, barbaric world? From slave dens to merchant cities to isolated mountains, Candas Jane Dorsey's novel is a powerful exploration of gender, identity, and freedom.
The Taste of Translation by Anne Gambling
Price: Free! Words: 137,550. Language: Commonwealth English. Published: September 5, 2013. Categories: Fiction » Literature » Literary
A Muslim princess learns to die to self, a Christian translator learns there are other ways to write, and a secular exile from the Bosnian War learns to open to her past in order to embrace the future. Across a shifting landscape spanning Europe and North Africa, and bridging more than six centuries, their pilgrimages to the centre of being tell a single story – of what it means to love.
Letters From Leonard by S.E. Kennedy
Price: $4.99 USD. Words: 213,970. Language: English. Published: August 29, 2013 by Proglen. Categories: Fiction » Literature » Literary, Fiction » Literature » Plays & Screenplays
When Paul receives a phone call telling him his best friend has committed suicide, he begins reading Leonard's old letters in an effort to find out why. This turns into a journey of discovery as Paul becomes obsessed with tracing his friend's steps over the last days and months of his life. Along the way, he comes face to face with his own demons and self-destructive nature.
The Years by Alexis Scott
Price: Free! Words: 141,190. Language: English. Published: August 29, 2013. Categories: Fiction » Literature » Literary, Fiction » Thriller & suspense » Courtroom
Told in the forceful language of Derry's streets, The Years is a roller coaster ride down forty years of the town's history. Francie, released from jail after a long sentence, is trying to come to terms with the changes peace has brought, as well as dealing with what he did – and didn't – do on Bloody Sunday.
The Jig of the Union Loller by Michael Burnham
Price: Free! Words: 130,370. Language: English. Published: August 18, 2013 by The Wessex Collective. Categories: Fiction » Literature » Literary
A loller is a shirker, a slacker, a goof-off, an idler, a goldbrick, a dirtball, a ne'er-do-well—all of which define Claude Amognes's behavior quite nicely. So he's a good-time Charlie who smokes and drinks too much and does as little work as necessary; but while all these things are true, he's also a delightful Falstaffian character. He's what makes reading this book such rollicking
Master Gardener by Rolf Margenau
Series: Wylie Cypher, Two. Price: $3.99 USD. Words: 102,350. Language: American English. Published: August 15, 2013. Categories: Fiction » Humor & comedy » Satire, Fiction » Literature » Literary
A humorous look at the problems presented by genetically altered seeds and chemicals that prohibit growth of weeds. Anne Proctor, Master Gardener in New Anglia, finds magic seeds that produce "super plants" that threaten the profitable seed business of BIG AG. Wylie Cypher, retired lawyer, battles BIG AG. Eco-terrorism group saves monarch butterfly. Fun and satisfying 300 pages!
Nietzsche, A Fictional Biography by Suzanne Steinberg
Price: $5.99 USD. Words: 196,740. Language: English. Published: August 3, 2013. Categories: Fiction » Historical » General, Fiction » Literature » Literary(5.00 from 1 review)
There are no answers to humanity's pain, but Nietzsche was one of the few men who dared to look into the abyss and ask why.
June and Jitter (The Bugs) by David Keffer
Price: $2.99 USD. Words: 105,450. Language: English. Published: July 25, 2013. Categories: Fiction » Literature » Literary
"June and Jitter (the bugs)" can most succinctly be described as the bastard child produced from the unholy union of Ray Bradbury's "The Martian Chronicles" and an unrelenting dose of the clinical absurdism of Kobo Abé.
Borrowed Things by Doris Schneider
Price: $4.99 USD. Words: 117,910. Language: English. Published: July 3, 2013. Categories: Fiction » Literature » Literary, Fiction » Women's fiction » General
Borrowed Things is set in North Carolina, alternating between Durham and a fictional coastal town on the Lockwood Folly River. Anne Gray, a woman with a troubled past, finds a new home in the dying town of Pearl where she releases the memories of two failed marriages as she sails the waters of the Innercoastal Canal with a haunted Latino priest and an elderly woman who wears No Fear t-shirts.


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Seattle University used an early run and was never challenged in an 84-62 Western Athletic Conference women's basketball victory over Texas-Pan American on Saturday.
The Redhawks went on a 19-5 run for a 21-10 lead eight minutes into the game and steadily pulled away.
Sylvia Shephard had 20 points, seven assists and seven rebounds for the Redhawks (8-9, 3-1 WAC). Kacie Sowell scored 16 points and Ashley Ward 10.
Shawnte' Goff led the Broncs (7-9, 1-2) with 14 points.
- Our state's greatest gift to the nation just got canceled
- Roads could be a mess this weekend — and Monday
- New GM Jerry Dipoto provides more insight into how he'll turn Mariners around
- Seven things to know about Seahawks rookie Tyler Lockett
- Survivor: Gunman spared 'lucky one' to give police message
Most Read Stories
"I thought the first half was the best half we've played all year," said Redhawks coach Joan Bonvicini.


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Tag: Wile E. Coyote and Roadrunner
How To Earn $70,000 From Looney Tunes Cartoons And Not Pay Warner Bros. A Cent [Updated]
Illustrator Rob Loukotka's ACME Corporation Kickstarter project is worth writing about for many reasons besides the fact that he's trying to raise money.
Wile E. Coyote in "127 Hours"
New York based animator Rob Yulfo came up with this parody of the recent Danny Boyle, James Franco movie:
Live-Action Coyote vs. Roadrunner Fan Film
This live-action Wile E. Coyote and Roadrunner fan film defies expectations and replaces the cartoon characters with human versions. It's …


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Are you Haiquan Chen?Claim your profile
Publications (113)633.64 Total impact
Article: EGFR Exon 18 Mutations in East Asian Patients with Lung Adenocarcinomas: A Comprehensive Investigation of Prevalence, Clinicopathologic Characteristics and Prognosis[Show abstract] [Hide abstract]
ABSTRACT: Our aim was to investigate the clinical and pathologic characteristics of the epidermal growth factor receptor (EGFR) exon 18 mutations in East Asian lung adenocarcinomas patients. A total of 1,201 lung adenocarcinomas were analyzed for mutation in EGFR. Clinical and pathologic characteristics of patients with EGFR exon 18 mutations were compared with those who harbored classic activating mutations (exon 19 deletions and the L858R point mutation). The mutations in EGFR exon 18 were observed in 2.8% of 1,201 lung adenocarcinomas and 4.6% of patients with EGFR mutations. Patients with a single EGFR exon of 18 mutations had a worse overall survival than those harboring the complex EGFR exon of 18 mutations (p = 0.002) or those with classic activating mutations (p = 0.014). Four of five patients with EGFR exon 18 mutations showed objective response to the EGFR-TKI therapies after disease recurrence. Our results demonstrated that single EGFR exon 18 mutations may be an indicator of poor prognosis compared with complex EGFR exon 18 mutations or classic mutations. Furthermore, the results of the current study will be helpful for decision-making in the treatment of patients with EGFR exon 18 mutations.Scientific Reports 09/2015; 5:13959. DOI:10.1038/srep13959 · 5.58 Impact Factor
Article: Phosphorylated AKT1 is associated with poor prognosis in esophageal squamous cell carcinoma[Show abstract] [Hide abstract]
ABSTRACT: The epidermal growth factor receptor (EGFR) signaling pathway is important in regulating biological behaviors in many malignancies. We explored whether expression and activation of EGFR and several components on its downstream pathways have prognostic significance in patients with esophageal squamous cell carcinoma (ESCC). Expression of EGFR, phosphorylated (p)-EGFR, AKT1, p-AKT1, AKT2, p-AKT2, ERK1, ERK2, p-ERK1/2, STAT3, and p-STAT3 was assessed by immunohistochemical analysis of tissue microarrays for 275 ESCC patients who had undergone complete three-field lymphadenectomy. Spearman rank correlation tests were used to determine the relationships among protein expression, and Cox regression analyses were performed to determine the prognostic factors on overall survival (OS). p-EGFR expression was correlated statistically with all of the other phosphorylated markers. Gender, N stage, and p-AKT1 expression were found to be independent prognostic factors for OS. Increased expression of p-AKT1 was associated with decreased patient survival. EGFR and p-EGFR expression was not significantly associated with patient survival. Activation of AKT1 was associated with poor prognosis in ESCC.Journal of Experimental & Clinical Cancer Research 09/2015; 34(1):95. DOI:10.1186/s13046-015-0212-z · 4.43 Impact Factor
Article: Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Lung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding of mutational landscape for this subtype of lung cancer in Chinese patients is currently limited. We performed whole exome sequencing in samples from 100 patients with lung SQCCs to search for somatic mutations and the subsequent target capture sequencing in another 98 samples for validation. We identified 20 significantly mutated genes, including TP53, CDH10, NFE2L2 and PTEN. Pathways with frequently mutated genes included those of cell-cell adhesion/Wnt/Hippo in 76%, oxidative stress response in 21%, and phosphatidylinositol-3-OH kinase in 36% of the tested tumor samples. Mutations of Chromatin regulatory factor genes were identified at a lower frequency. In functional assays, we observed that knockdown of CDH10 promoted cell proliferation, soft-agar colony formation, cell migration and cell invasion, and overexpression of CDH10 inhibited cell proliferation. This mutational landscape of lung SQCC in Chinese patients improves our current understanding of lung carcinogenesis, early diagnosis and personalized therapy.Scientific Reports 08/2015; · 5.58 Impact Factor
Article: Prevalence and Clinicopathological Characteristics of BRAF Mutations in Chinese Patients with Lung Adenocarcinoma[Show abstract] [Hide abstract]
ABSTRACT: This study was designed to identify the prevalence of BRAF mutations in Chinese patients with lung adenocarcinoma, and to reveal the association between BRAF mutations and clinicopathological characteristics in these patients. From October 2007 to February 2013, patients with newly diagnosed primary lung adenocarcinoma were detected for mutations in BRAF, EGFR, KRAS, HER2 and ALK. Clinicopathological characteristics, including sex, age, TNM stage, tumor differentiation, smoking status, histological subtypes, and survival information were analyzed. Of 1358 patients with lung adenocarcinoma, 20 patients were harboring BRAF mutations, including five BRAF V600E mutations and 15 BRAF non-V600E mutations. Among these, BRAF N581I and BRAF G593S were newly reported. BRAF mutations were associated with smoking status (odds ratio 3.28; 95 % CI 1.33-8.08; p = 0.008). In patients less than 60 years of age, BRAF mutations tended to have poor differentiation in tumor samples (70.0 vs. 35.1 %; p = 0.014), and were more likely to relapse (70 vs. 28 %; p = 0.008). A significant difference was found in relapse-free survival (RFS) between BRAF mutations and other mutations, but not in overall survival. The prevalence of BRAF mutations in Chinese patients with lung adenocarcinoma was approximately 1.5 %. BRAF mutations were more frequent in current smokers. Patients harboring BRAF mutations had a higher rate of recurrence and worse RFS compared with other patients.Annals of Surgical Oncology 07/2015; DOI:10.1245/s10434-015-4640-y · 3.93 Impact Factor
Article: Negative Thyroid Transcription Factor 1 Expression Defines an Unfavorable Subgroup of Lung Adenocarcinomas[Show abstract] [Hide abstract]
ABSTRACT: Thyroid transcription factor 1 (TTF1) is a master regulator of pulmonary differentiation that is downregulated in a subset of lung adenocarcinoma, of which the clinicopathologic characteristics were not fully clarified. One thousand forty-two lung adenocarcinoma patients who underwent surgery were investigated for clinic characteristics, histologic subtyping, and spectrum of well-identified driver mutations. TTF1 expression was correlated with these clinicopathologic factors and survival. Compared with TTF1 positive (TTF1+) patients, the 133 negative individuals (12.8%, TTF1-) were more likely to be male (p = 0.006) and heavy smokers (p = 0.002) who had larger tumor size (p < 0.001) and more advanced disease stage (p < 0.001). TTF1- presented more in solid and invasive mucinous-predominant carcinomas (both p < 0.001), whereas TTF1+ was identified in 100% patients with adenocarcinoma in situ, minimally invasive and lepidic-predominant adenocarcinomas. The TTF1- tumors harbored the known driver mutations in significantly low frequency compared with TTF1+ adenocarcinomas (57.8% versus 78.1%, p < 0.001), especially in epidermal growth factor receptor (EGFR) mutations (37.6% versus 60.7%, p < 0.001). There was no significant difference in recurrence-free survival between the TTF1- and TTF1+ patients, either for the whole cohort or stratified by pathologic stage, or among the driver mutation-defined subsets. However, recurrence of multiple metastases was more likely to occur in patients with TTF1- adenocarcinomas (88.1% versus 32.4%, p < 0.001). Multivariate analysis revealed that TTF1- -independently predicted both poor postrecurrence survival (hazard ratio = 1.664; 95% confidence interval , 1.097-2.524; p = 0.017) and unfavorable overall survival (hazard ratio = 1.553; 95% confidence interval , 1.013-2.381; p = 0.043). TTF1- correlated with solid and invasive mucinous subtypes of lung adenocarcinoma and lower frequency of EGFR mutations. It defines a subgroup of lung adenocarcinomas with unfavorable outcomes.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 07/2015; DOI:10.1097/JTO.0000000000000626 · 5.28 Impact Factor
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ABSTRACT: This study investigated the association between clinical pathologic features, especially adenocarcinoma subtypes and prognosis, and skip N2 metastasis in patients with lung adenocarcinoma. In this study, 177 patients with lung adenocarcinoma and N2 metastasis were enrolled. Patients who had N2 lymph node metastases without N1 lymph node involvement were defined as skip N2 and otherwise as non-skip N2. We investigated the difference of clinicopathologic characteristics, recurrence-free survival, overall survival, and spectrum of well-identified molecular alterations in EGFR, KRAS, HER2, BRAF, ALK, ROS1, and RET genes in the 2 groups. Skip N2 metastasis was found in 45 patients, in whom a remarkably lower incidence of lymphovascular invasion was revealed (P = .01). Skip N2 metastasis was also associated with acinar subtype, good differentiation, and right lung cancer. The recurrence-free survival and overall survival were significantly better in the skip N2 group (5-year recurrence-free survival 37.4% vs 5.7%; log-rank P = .005; 5-year overall survival 60.7% vs 32.1%; log-rank P = .024). The predictive value of skip N2 was more significant in patients with lesions in the right lung (5-year recurrence-free survival 36.6% vs 0.0%; log-rank P = .002; 5-year overall survival 57.2% vs 27.9%; log-rank P = .016) and in patients whose tumor diameter was no more than 3 cm (5-year recurrence-free survival 43.1% vs 6.7%; log-rank P = .01; 5-year overall survival 74.6 vs 27.6%; log-rank P = .04). There are distinct differences in clinicopathologic features and prognosis in patients with or without skip N2 metastasis. Considering the results of our study, subclassifications of mediastinal lymph node metastases could have clinical significance for patients with lung adenocarcinoma. Copyright © 2015 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.The Journal of thoracic and cardiovascular surgery 07/2015; DOI:10.1016/j.jtcvs.2015.03.067 · 4.17 Impact Factor
Article: HGF and NRG1 protein expression are not poor prognostic markers in surgically resected lung adenocarcinoma[Show abstract] [Hide abstract]
ABSTRACT: Although over-expression of hepatocyte growth factor (HGF) and neuregulin-1 (NRG1) are important mechanisms involved in acquired drug-resistance in many cancers, few reports have evaluated their clinicopathologic features and prognostic significance. The aim of our study was to investigate protein expressions of HGF and NRG1 in lung adenocarcinomas and their association with clinicopathologic parameters, oncogenic mutations, and the prognosis. HGF and NRG1 protein tumor/stroma expressions were evaluated by immunohistochemistry (IHC) in 115 surgically resected lung adenocarcinomas and were correlated with clinicopathologic and molecular variables including tumor size, tumor node metastasis stage, differentiation, oncogenic mutations (EGFR, KRAS, HER2, BRAF) and ALK fusions, relapse-free survival, and overall survival. Positive IHC HGF tumor and stroma staining were found in 49 (42.61%) and 12 (10.43%) cases, respectively, while positive IHC NRG1 tumor and stroma staining were found in 56 (48.70%) and eleven (9.57%) cases, respectively. Dual positive IHC HGF and NRG1 tumor staining was 12.17%. EML4-ALK fusion more significantly existed in HGF-tumor positive samples (P=0.03), positive NRG1 protein stroma expression was significantly associated with male sex (P=0.04), while HGF and NRG1 dual tumor-positive mainly existed in the tumor size >3 cm group (P=0.0231). No significant clinically prognostic difference was found between patients with HGF/NRG1-positive expression and those with HGF/NRG1-negative expression. This study represents the first comprehensive analysis of HGF and NRG1 tumor and stroma expressions in patients with surgically resected lung adenocarcinomas. Our molecular data, in conjunction with clinical and pathological features, as well as their effects on survival indicated to us that patients with HGF- and NRG1-negative expression tended to have better survival, but these results probably did not warrant these markers to be indicators of poor prognosis.OncoTargets and Therapy 05/2015; 8:1185-91. DOI:10.2147/OTT.S78116 · 2.31 Impact Factor
Article: LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response[Show abstract] [Hide abstract]
ABSTRACT: LKB1 regulates both cell growth and energy metabolism. It remains unclear how LKB1 inactivation coordinates tumor progression with metabolic adaptation in non-small cell lung cancer (NSCLC). Here in Kras(G12D);Lkb1(lox/lox) (KL) mouse model, we reveal differential reactive oxygen species (ROS) levels in lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC). ROS can modulate ADC-to-SCC transdifferentiation (AST). Further, pentose phosphate pathway deregulation and impaired fatty acid oxidation collectively contribute to the redox imbalance and functionally affect AST. Similar tumor and redox heterogeneity also exist in human NSCLC with LKB1 inactivation. In preclinical trials toward metabolic stress, certain KL ADC can develop drug resistance through squamous transdifferentiation. This study uncovers critical redox control of tumor plasticity that may affect therapeutic response in NSCLC. Copyright © 2015 Elsevier Inc. All rights reserved.Cancer cell 04/2015; 27(5). DOI:10.1016/j.ccell.2015.04.001 · 23.52 Impact Factor
Article: Incidence and management of chylothorax after esophagectomy: Chylothorax after esophagectomy[Show abstract] [Hide abstract]
ABSTRACT: Background Chylothorax is a rare but serious postoperative complication in esophageal cancer patients. The aim of this study was to identify risk factors associated with chylothorax and the indication for surgical intervention.MethodsA consecutive series of 1290 patients who underwent esophagectomy for esophageal cancer was included. Peri-operative data, including postoperative morbidity and mortality, were analyzed.ResultsThirty-four patients (2.6%) developed chylothorax and had significantly higher instances of pneumonia (26.5% vs. 11.1%, P = 0.012) and arrhythmia (17.6% vs. 2.9%, P = 0.001), and a longer hospital stay (22 vs. 18 days, P < 0.001). Reoperation was performed in 11 patients at a rate of 77.8%, 42.9%, 20%, and 0% for chylothorax diagnosed in two, three, four, and >= 5 days, respectively, after esophagectomy (P < 0.001). After three days of conservative therapy, the chest tube output was significantly greater in patients whose medical management had failed than in those successfully treated (P < 0.001). All patients who required reoperation had >= 13.5 ml/kg of drainage (sensitivity 100%); four of 23 patients with successful medical management had a chest tube output >= 13.5 ml/kg (specificity 83%). Logistic regression analysis showed that body mass index (BMI) < 25 was an independent risk factor for chylothorax (hazard ratio = 9.256, P = 0.029).Conclusions Patients with a BMI < 25 are more likely to develop chylothorax after esophagectomy. Operative therapy should be seriously considered in patients who develop chylothorax early postoperatively. In addition, a high daily chylous output of >= 13.5 ml/kg after three days of conservative therapy might be a reliable indicator for reoperation.Thoracic Cancer 03/2015; 6(3). DOI:10.1111/1759-7714.12240 · 0.90 Impact Factor
Article: Comparison of Ivor-Lewis vs Sweet Esophagectomy for Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial.[Show abstract] [Hide abstract]
ABSTRACT: Sweet esophagectomy is performed widely in China, while the Ivor-Lewis procedure, with potential benefit of an extended lymphadenectomy, is limitedly conducted owing to concern for a higher risk for morbidity. Thus, the role of the Ivor-Lewis procedure for thoracic esophageal cancer needs further investigation. To determine whether Ivor-Lewis esophagectomy is associated with increased postoperative complications compared with the Sweet procedure. A randomized clinical trial was conducted from May 2010 to July 2012 at Fudan University Shanghai Cancer Center, Shanghai, China, of 300 patients with resectable squamous cell carcinoma in the middle and lower third of the thoracic esophagus. Intent-to-treat analysis was performed. Patients were randomly assigned to receive either the Ivor-Lewis (n = 150) or Sweet (n = 150) esophagectomy. The primary outcome of this clinical trial was operative morbidity (any surgical or nonsurgical complications). Secondary outcomes included oncologic efficacy (number of lymph nodes resected and positive lymph nodes), postoperative mortality (30-day and in-hospital mortality), and patient discharge. Resection without macroscopical residual (R0/R1) was achieved in 149 of 150 patients in each group. Although there was no significant difference between the 2 groups regarding the incidence of each single complication, a significantly higher morbidity rate was found in the Sweet group (62 of 150 [41.3%]) than in the Ivor-Lewis group (45 of 150 [30%]) (P = .04). More patients in the Sweet group (8 of 150 [5.3%]) received reoperations than in the Ivor-Lewis group (1 of 150 [0.7%]) (P = .04). The median hospital stay was 18 days in the Sweet group vs 16 days in the Ivor-Lewis group (P = .002). Postoperative mortality rates in the Ivor-Lewis (1 of 150) and Sweet (3 of 150) groups were 0.7% and 2.0%, respectively (P = .25). More lymph nodes were removed during Ivor-Lewis esophagectomy than during the Sweet procedure (22 vs 18, P < .001). Early results of this study demonstrate that the Ivor-Lewis procedure can be performed with lower rates of postoperative complications and more lymph node retrieval. Ivor-Lewis and Sweet esophagectomies are both safe procedures with low operative mortalities. clinicaltrials.gov Identifier:NCT01047111.02/2015; 150(4). DOI:10.1001/jamasurg.2014.2877
Article: The correlation of morphological features of chest computed tomographic scans with clinical characteristics of thymoma[Show abstract] [Hide abstract]
ABSTRACT: Chest computed tomography (CT) scanning has been widely utilized in thymoma identification and staging as well as in follow-up monitoring for recurrence. However, the relationship between some CT imaging features and pathological types, clinical stage, completeness of resection, or prognosis in thymoma has not been well explored. We retrospectively reviewed preoperative CT imaging for 238 thymoma patients, who had undergone thymectomy from October 2007 to December 2011. All CT parameters were assessed in each case based on clinical and pathological data. Survival analysis was performed by using the Kaplan-Meier and log-rank tests. Tumour contours (P = 0.008), homogeneity (P = 0.009), degree of enhancement (P = 0.013), fat plane obliteration with adjacent structures (P < 0.001), the presence of mediastinal lymphadenopathy (P = 0.010), irregular infiltration into the lung (P = 0.012) and tumour shape (P = 0.007) were associated with the World Health Organization (WHO) histological classification. Lobulated or irregular tumour contours (P < 0.001), presence of calcifications (P = 0.002), infiltration of surrounding fat (P < 0.001), irregular infiltration into the lung (P < 0.001), irregular infiltration into vascular (P < 0.001), more abutment of vessels (P < 0.001) and pulmonary changes adjacent to the tumour (P < 0.001) were associated with the more advanced Masaoka-Koga clinical stage. Tumour contours (P < 0.001), infiltration of surrounding fat (P = 0.008), irregular infiltration into the lung (P < 0.001) and degree of abutment of vessel circumference (P = 0.001) were associated with completeness of resection. With multivariate analysis, no CT image features could reliably predict on the overall or disease-free survival rate. CT imaging does have some features, which are significantly correlated with the WHO classification, the Masaoka-Koga clinical staging and the completeness of resection, although it has no definite role to evaluate preoperatively the survival rate of thymoma patients. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery 12/2014; DOI:10.1093/ejcts/ezu475 · 3.30 Impact Factor
Article: A high body mass index in esophageal cancer patients is not associated with adverse outcomes following esophagectomy[Show abstract] [Hide abstract]
ABSTRACT: There is no consensus about the impact of a high BMI on postoperative morbidity and survival after esophagectomy. The aim of this study was to determine the influence of a high BMI on postoperative complications and survival in a large cohort of esophageal cancer patients. From January 2006 to December 2012, 1,342 consecutive esophageal cancer patients who underwent esophagectomy were included in this study. Patients were divided into three groups: 950 patients were classified as normal BMI (BMI 18.5-24.9 kg/m(2)), 279 were classified as high BMI (BMI ≥ 25 kg/m(2)), and 113 as low BMI (BMI < 18.5 kg/m(2)). Multivariate logistic regression models were used to identify confounding factors associated with postoperative complications. The impact of BMI on overall survival (OS) was estimated by the Kaplan-Meier method and Cox proportional hazard models. The predominance of pathological type was esophageal squamous cell carcinoma (n = 1,280, 95.4 %). Overall morbidity, mortality, and hospital stay did not differ among groups. The incidence of pneumonia was higher in patients with high BMI compared with those with normal BMI (14.7 vs. 9.9 %, P = 0.025). However, chylothorax was less frequent in high-BMI group (0.4 % in high-BMI group, 3.1 % in normal group, and 3.5 % in low group, P = 0.011). Logistic regression analysis revealed high BMI was independently associated with decreased incidence of chylothorax [HR 0.86; 95 % confidence interval 0.76-0.97]. Overweight and obese patients had significantly better overall survival than underweight patients (median OS 55.6 vs. 32.5 months, P = 0.013), while the pathological stage was significantly higher in underweight patients (P = 0.001). In multivariate analysis, T status, N status, differentiation grade, and tumor length were identified as independent prognostic factors. A high BMI is not associated with increased overall morbidity following esophagectomy; moreover, it is associated with decreased incidence of chylothorax. The better overall survival in patients with high BMI compared with those with low BMI might be due to a relatively low pathological stage. A high BMI should therefore not be a relative contraindication for esophagectomy.Journal of Cancer Research and Clinical Oncology 11/2014; 141(5). DOI:10.1007/s00432-014-1878-x · 3.08 Impact Factor
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ABSTRACT: A total of 1039 stage I-III invasive lung adenocarcinoma including 186 solid subtype patients who have undergone radical resection were assessed for clincopathlogic characteristics, status of common driver mutations, pattern of recurrence, recurrence-free survival (RFS), overall survival (OS), post-recurrence survival (PRS) and predictive value for adjuvant chemotherapy and EGFR tyrosine kinase inhibitors (TKIs). Solid predominant adenocarcinomas were more likely to have initial distant recurrences than non-solid subtype invasive adenocarcinomas (P = 0.018). In univariate analysis, solid predominant adenocarcinoma patients had significantly worse RFS (P < 0.001), OS (P < 0.001) and PRS (P = 0.010). Multivariate analysis adjusting for clinicopathologic variables and mutational status showed that solid subtype was an independent poor prognostic factor (odds ratio = 1.876, 95% confidence interval: 1.291-3.158; P = 0.003) and an independent negative predictor for stage II-III patients undergoing adjuvant chemotherapy (odds ratio = 2.020, 95% confidence interval: 1.291-3.158; P = 0.002). In EGFR-mutated solid predominant lung adenocarcinoma patients who experienced disease recurrence, the response rate to EGFR TKIs was only 37.5%. In radically resected invasive lung adenocarcinoma, solid subtype was an independent poor prognostic factor and negative predictor for adjuvant chemotherapy.Scientific Reports 11/2014; 4:7163. DOI:10.1038/srep07163 · 5.58 Impact Factor
Article: Comparison of clinical features, molecular alterations, and prognosis in morphological subgroups of lung invasive mucinous adenocarcinoma[Show abstract] [Hide abstract]
ABSTRACT: We performed this analysis to distinguish the differences in two subtypes of lung invasive mucinous adenocarcinoma (IMA) with different kinds of morphological performances, in clinicopathological and molecular features, as well as prognosis. On the basis of morphological performance, we divided lung IMAs into two subgroups, mucus-in-cell adenocarcinoma (MICA) and mucus-out-of-cell adenocarcinoma (MOCA). We investigated differences in clinicopathological characteristics, recurrence-free survival (RFS), overall survival (OS), and a spectrum of well-identified driver-gene mutations, including EGFR, KRAS, HER2, BRAF, ALK, ROS1, and RET, between the two subgroups. Of 1,699 lung adenocarcinomas, 148 were identified as IMAs (97 MICAs and 51 MOCAs). The MICA patient group had significantly better RFS than did the MOCA group (39.4 months versus 33.0 months, respectively, log rank P=0.020) and significantly better OS (54.2 months versus 45.1 months, log rank P=0.034). There were no differences in RFS and OS between those with IMAs and those with mucus-negative adenocarcinomas. The frequency of the EGFR gene mutation was significantly higher in MOCAs than in MICAs (P<0.001). In contrast, the KRAS gene had a significantly higher mutational frequency in MICAs (P=0.01). MOCAs also had a significantly higher incidence of lymph-node metastasis (P<0.05). To our knowledge, this study represents the first comparison of clinical features, molecular alterations, and prognosis in morphological subgroups of lung IMAs. Clinical and pathological features in conjunction with molecular data indicate that IMA should be divided into different subgroups.OncoTargets and Therapy 11/2014; 7:2127-2132. DOI:10.2147/OTT.S70984 · 2.31 Impact Factor
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ABSTRACT: Introduction The recurrent TERT promoter mutations have been recently described in diverse human cancers. We previously showed that over 60% of non-small cell lung cancer from East Asian harbored well-known oncogenic mutations in EGFR and KRAS. Here, we sought to determine the incidence, clinicopathologic characteristics, and association with known oncogenic mutations. Patients and Methods A total of 467 patients treated surgically for primary lung cancer were examined for mutations in TERT promoter using polymerase chain reaction (PCR) followed by Sanger sequencing. Immunohistochemical (IHC) staining was performed to detect the expression of TERT. Clinical characteristics including gender, age, smoking status, tumor size, differentiation, lymph node metastasis, TNM stage, overall survival and relapse-free survival were analyzed. Results Of 467 patients with non-small cell lung cancer, the TERT promoter mutation was detected in 12 patients. Of the 12 patients, 3 with C228 T, 2 with C250 T, 2 with C216 T, 1 with C228A, 1 with C229G, 1 with G267 C, 1 with C295 T and 1 with G233 C. Compared to the TERT mutation negative group, patients with TERT promoter mutation were significantly associated with older age (≥60 years, P = 0.039). No significant difference was found in overall survival (OS) or relapse-free survival (RFS) between TERT with mutation and TERT without mutation. Conclusions TERT promoter mutations are recurrent mutated in 2.57% of NSCLCs and are highly enriched in older patients. It may play an important role in the pathogenesis of NSCLC and may serve as a potential target for therapy.Lung Cancer 10/2014; 86(3). DOI:10.1016/j.lungcan.2014.10.009 · 3.96 Impact Factor
Article: Meta-analysis of lobectomy, segmentectomy, and wedge resection for stage I non-small cell lung cancer[Show abstract] [Hide abstract]
ABSTRACT: Background Survival difference following lobectomy, segmentectomy, and wedge resection in stage I non-small cell lung cancer (NSCLC) and its subgroups remains undetermined.Methods We systemically searched published articles comparing recurrence-free survival (RFS), overall survival (OS), or cancer-specific survival (CSS) between lobectomy and limited resection or between segmentectomy and wedge resection.ResultsA total of 42 studies published from 1980 to 2014 enrolling 21,926 patients were included in this meta-analysis. Survival results favored lobectomy in stage IA NSCLC ≤2 cm (combined HR: 1.530, 95% CI: 1.402–1.671, P < 0.001) or patient's ≥65 years old (combined HR: 1.227, 95% CI: 1.003–1.502, P = 0.047). Survival outcome of video-assisted thoracoscopic (VATS) sublobectomy was comparable to that of VATS lobectomy (pooled HR: 0.808, 95% CI: 0.556–1.174, P = 0.263). The combined HR of segmentectomy versus lobectomy was 1.231 (95% CI: 1.070–1.417, P = 0.004), while the pooled HR of wedge resection versus segmentectomy was 1.542 (95% CI: 0.856–2.780, P = 0.149).Conclusions This study suggested that tumor size or age alone should not be the criteria to encourage sublobar resection. For stage I NSCLC, survival following segmentectomy was inferior to lobectomy. Patients undergoing intentional sublobectomy achieved comparable survival as those who received lobectomy. J. Surg. Oncol. © 2014 Wiley Periodicals, Inc.Journal of Surgical Oncology 10/2014; 111(3). DOI:10.1002/jso.23800 · 3.24 Impact Factor
Article: Analysis of the molecular and clinicopathologic features of surgically resected lung adenocarcinoma in patients under 40 years old[Show abstract] [Hide abstract]
ABSTRACT: Introduction: The youthful lung cancer may constitute an entity with distinct clinicopathologic characteristics and a controversial prognosis compared with the older counterpart. Whether the youthful lung cancer has the exclusively distinct molecular features has not been well investigated. Methods: Thirty-six resected lung adenocarcinomas from young patients under 40 years old were analyzed concurrently for mutations in EGFR, KRAS, HER2, BRAF, AKT1, ALK, RET, TP53 and LKB1 and enrolled as the younger group. Their molecular and clinicopathologic characteristics were compared with those of 87 adenocarcinoma cases from patients above 40 years old which were collected as the older group. Results: The comparable overall survival (OS) (P=0.942), more early adenocarcinomas (P=0.033), more wedge resections (P<0.001) and fewer smokers (P=0.004) were seen in the younger group, when compared with the clinicopathologic characteristics in the older group. Nineteen EGFR mutations (52.8%), 3 KRAS mutations (8.3%), 2 EML4-ALK fusions (5.6%) and 1 KIF5b-RET fusion (2.8%) were identified in the younger group. The difference of oncogenic mutations between the two groups was statistically insignificant (P=0.396). Twenty-six TP53 mutations (72.2%) and 4 LKB1 mutations (11.1%) were found in the younger group. When compared with the old patients, young patients showed a higher prevalence of TP53 mutations (P<0.001) and a comparable prevalence of LKB1 mutations (P=0.951). Conclusions: The youthful lung cancer unequivocally presented the distinct clinicopathologic characteristics including more early adenocarcinomas and fewer smokers. It showed the similar oncogenic characteristics and higher prevalence of TP53 mutations compared with the older counterpart.Journal of Thoracic Disease 10/2014; 6(10):1396-402. DOI:10.3978/j.issn.2072-1439.2014.08.50 · 1.78 Impact Factor
Article: Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: Challenges and perspectives[Show abstract] [Hide abstract]
ABSTRACT: Lung cancer, mostly nonsmall cell lung cancer, continues to be the leading cause of cancer-related death worldwide. With the development of tyrosine kinase inhibitors that selectively target lung cancer-related epidermal growth factor receptor mutations, management of advanced nonsmall cell lung cancer has been greatly transformed. Improvements in progression-free survival and life quality of the patients were observed in numerous clinical studies. However, overall survival is not prolonged because of later-acquired drug resistance. Recent studies reveal a heterogeneous subclonal architecture of lung cancer, so it is speculated that the tumor may rapidly adapt to environmental changes via a Darwinian selection mechanism. In this review, we aim to provide an overview of both spatial and temporal tumor heterogeneity as potential mechanisms underlying epidermal growth factor receptor tyrosine kinase inhibitor resistance in nonsmall cell lung cancer and summarize the possible origins of tumor heterogeneity covering theories of cancer stem cells and clonal evolution, as well as genomic instability and epigenetic aberrations in lung cancer. Moreover, investigational measures that overcome heterogeneity-associated drug resistance and new assays to improve tumor assessment are also discussed.OncoTargets and Therapy 09/2014; 7:1689-704. DOI:10.2147/OTT.S66502 · 2.31 Impact Factor
Article: Response to crizotinib observed in metastatic mediastinum lymph node from a non-small cell lung cancer patient harboring EZR-ROS1 fusionJournal of Cancer Research and Clinical Oncology 09/2014; 141(1). DOI:10.1007/s00432-014-1821-1 · 3.08 Impact Factor
Article: A Comprehensive Investigation of Molecular Features and Prognosis of Lung Adenocarcinoma with Micropapillary Component[Show abstract] [Hide abstract]
ABSTRACT: Introduction: Both micropapillary predominant lung adenocarcinoma according to the IASLC/ATS/ERS classification and lung adenocarcinoma with a micropapillary component have been reported to be associated with poor prognosis. However, whether they have different prognosis remains undetermined. Methods: Out of 1302 lung adenocarcinoma patients, 21 patients with micropapillary predominant lung adenocarcinoma (MPP) and 100 patients with nonmicropapillary predominant tumors harboring a micropapillary component of at least 5% (MPC) were investigated for clinicopathologic characteristics, recurrence-free survival (RFS), overall survival (OS), and spectrum of well-identified driver mutations including EGFR, KRAS, HER2, BRAF, ALK, ROS1, and RET. Results: Twenty out of 21 (95.2%) micropapillary predominant lung adenocarcinoma harbored driver mutations in EGFR (85.7%), HER2 (4.8%), or RET (4.8%). MPP had significantly worse RFS than MPC in stage I patients (p = 0.003), but not in stages II-III patients. The overall survival was comparable between MPP and MPC regardless of disease stages. Objective response was achieved in 13 out of the 18 MPP or MPC patients with EGFR mutations who received EGFR tyrosine kinase inhibitors (TKIs) after disease recurrence. The postrecurrence survival was significantly better in EGFR-mutated patients who were treated with EGFR TKIs compared to those who did not receive TKIs (p = 0.003). Conclusions: Micropapillary predominant lung adenocarcinoma is a disease that could be largely defined by targetable driver mutations. For stage I lung adenocarcinoma, MPP was even more likely to recur than MPC. EGFR TKIs might help to control the recurrent disease for MPP or MPC patients harboring EGFR mutations.Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 09/2014; 9(12). DOI:10.1097/JTO.0000000000000341 · 5.28 Impact Factor
Top Journals
Fudan University
Shanghai, Shanghai Shi, China
- Department of Oncology
Vanderbilt University
Нашвилл, Michigan, United States
- Department of Biomedical Informatics
Massachusetts General Hospital
Boston, Massachusetts, United States
- Department of Pathology
Shanghai Jiao Tong UniversityShanghai, Shanghai Shi, China


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National Cheesecake Day 2015 | Half Price at Cheesecake Factory
Yum! It's that time of year again, time to celebrate National Cheesecake Day 2015! On July 29th & 30th, you can get half price cheesecake at the Cheesecake Factory. They have some amazing, different kinds of cheesecake that will cure any sweet tooth!View Post
National Hot Dog Day 2015 | $1 Sonic Hot Dogs (7/23)!
Here's a GREAT deal happening All Day Tomorrow at Sonic! You can get $1 Hot Dogs all day long on July 23rd, so grab the kids, pick up Sonic and hit the park! My kids always think we are having a blast when we take lunch to the park and this is an easy and inexpensive way to feed the family tomorrow!View Post
Papa John's 4th of July Coupon | Large Pizza $7.04!
Here's a fantastic Papa Johns Coupon Code for you to use this weekend! You can get a Large 1 Topping Pizza for just $7.04 at Papa John's when you use the coupon code JULY4 at checkout.View Post
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text: I stayed at this quaint premises with several colleagues as part of a work trip. I booked the "new" garden suite, located in a separate small building behind the main inn building. Luckily for me, we got a special group rate and this room (normally more expensive) was the same rate my colleagues paid. It was like having a separate... More