text:
Palestinians in Gaza speak of life under Israeli occupation.
"My Nigeria is my earth, my material, my jokes"
28 Aug 2013 20:19 GMT | Politics, Africa, Kenya, Rwanda, Uganda
The presidents of Kenya, Uganda and Rwanda have officially opened a new dock at Kenya's Mombasa port after a $66m makeover.
A significant portion of East African trade flows through this shipping hub, but it has been hit in recent years by congestion, delays and corruption.
Al Jazeera's Gerald Tan reports.
Source: Al Jazeera
New leadership vows to tackle youth unemployment of 80 percent but young people say past initiatives have failed.
Business & Economy, Africa, Kenya
Door-to-door vaccination programme launched after outbreak in Dadaab refugee camp.
Health, Africa, Kenya
Thanks to an innovative relocation programme, the Alameens' lives have changed dramatically after fleeing the war.
Refugees, Germany, Syrian crisis
After extending air war against fighters in Iraq, London contemplates military targets in Syria as well.
War & Conflict, United Kingdom, Middle East
Monsoon storms have wreaked havoc on Myanmar's persecuted Rohingya Muslims.
Rohingya, Human Rights, Weather
Critics lament New Delhi's fading pro-Palestinian stance at solidarity convention as Israel relations flourish.
Palestine, India, Gaza: After the war
Condemnation of verdict as Egypt court finds Baher Mohamed, Mohamed Fahmy, and Peter Greste guilty in delayed trial.
#FreeAJStaff, Politics, Media, Middle East, Egypt
More than 50,000 gather in Kuala Lumpur for two-day rally to demand resignation of Najib Razak over corruption scandal.
Malaysia, Politics, Human Rights, Asia Pacific, Corruption
People & Power investigates South Korea's disturbing rise in suicides, particularly among the elderly.
Health, Poverty & Development, South Korea
A story of political skulduggery in Yemen and the high cost to the presidency of alleged collusion with the Houthis.
War & Conflict, Politics, Yemen
South Sudan's president talks about the ongoing violence, internal rivalries, and the future of his country.
Politics, South Sudan, Sudan
The comedian gives an insight into his street-smart Nigerian life as he gets his act together and grows his brand.
Arts & Culture, Africa, Nigeria


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Deniliquin Oncology Unit to open in new year
Deniliquin's chemotherpy service, which was expected to start seeing patients in August, is yet to be officially opened.ZOE MCMAUGH December 28, 2012 9:43am
Deniliquin Oncology Outreach Unit is not yet fully operational, despite advice the service would be seeing patients from August.
Construction of the unit was completed in the first half of this year after funding was received in May 2011.
In July, when construction was completed, then Murrumbidgee Local Health District (MLHD) acting director of operations Ken Hampson told the Pastoral Times the service would start seeing patients by August.
MLHD group manager, Border, Rosemary Garthwaite, however, has confirmed the unit will not be available to patients until at least next month.
''The Deniliquin Oncology Outreach Unit will start treating its first patients early in the new year,'' she said.
''The unit is ready and nursing staff have been working the last several weeks to fine tune equipment and operational procedures.
''The unit will initially operate every Friday and medical oncologist bi-monthly visits to Deniliquin will continue as normal.
''The outreach clinic is for patients who are receiving treatment by Border Medical Oncology (BMO) in Wodonga.
''These patients will be assessed for their suitability to receive treatment at the unit by their medical oncologist.
''Patients will have their care jointly managed by their treating medical oncologist and local GP.''
The new service, located in the day surgery unit of Deniliquin Health Service, has been made possible through a $300,000 innovation grant from the Cancer Institute NSW.
The Naponda Hospital Auxiliary, Mayrung Hospital Auxiliary and Deniliquin Community Group supplied the funds to purchase the chemotherapy chairs, and have more funds in reserve for future oncology needs.
This month, Naponda Hospital Auxiliary provided another $19,700 for the centre.
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Monichino's life one from top shelf
Katunga winemaker Carlo Monichino lived life to the fullest and proved that anything was possible with hard work and a dream.
Lions finish on top
Although still not at their best, Mulwala have finished on top of the Murray League ladder after a comfortable victory over Cobram.
Guides off to 'Great Bunya'
The International Guide Jamboree will take place at Lake Somerset, South East Queensland from September 25 to October 3, for Guides aged 10-17 years, and will be hosted by Girl Guides Australia.
The drive to help out
CAMPASPE'S meals on wheels volunteers deserve to be celebrated.
Almost time to dig up the past
MANY things run in the family in Rochester.
Third is not safe
Kyabram under pressure to maintain vital top three spot
Can you help with soldier memorial?
The Seymour sub-branch of the RSL needs information on local soldiers during World War I.
Council guided by community
Berrigan public decides drainage works location
Earthcore boss defends his Pyalong festival
EARTHCOTE Events boss Spiro Boursinos has slammed allegations his annual Pyalong festival is anything but a safe and well organised function.
Defibrillator donated
Handymen and creative builders will now have a safer space to work in after a donation allowed the Cobram Men's Shed to invest in a defibrillator.
Community Champion
Cancer claims one of its fiercest combatants.
G-MW water allocations improve
Water allocations were increased in the Goulburn-Murray Water region today.
Ochestral delight
Students from South Gippsland jam with Rose City Band.
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A Walk in the Woods
These guys still know how to not just hold our attention but grab it, even if their current film needs them more than they need…
These guys still know how to not just hold our attention but grab it, even if their current film needs them more than they need…
War Room preaches that we have no call to be righteous and judge others, yet the film itself is righteous and judgmental in the extreme.
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
A report on the new Assistant Editors at RogerEbert.com.
Collin Souter, the author of our monthly series Short Films in Focus, picks one of Roger's pans as a time he felt aligned with him.
A report on the new Assistant Editors at RogerEbert.com.
Scout Tafoya's Unloved series continues with Roland Emmerich's "Anonymous."
A review of "A Girl at My Door".
An analysis of Hayao Miyazaki's attention to detail in his masterpiece, "Spirited Away."
A video tribute to Wes Craven.
Amazon's newest drama, Hand of God, is a repulsive waste of time.
Paul Devlin's "SlamNation" is a documentary about the 1996 National Poetry Slam, held in Portland, Ore., with 27 teams in the competition. The rules are simple: Four members to a team, every member must be a writer as well as a performer, no music, no props, no animal acts. There is a penalty for any poem that goes longer than three minutes. The judges are chosen from the audience. The performers are mostly dressed as if they're about to fix a leak in the basement.
Slams are nothing if not democratic. They are the only sport I'm aware of where the teams from Berwyn and San Francisco compete on the same field. (In 1996, Berwyn actually placed in the final four, led by its star, a slammer named Daniel Ferri, whose poem fiercely defends his baldness.) The documentary follows the New York team, which fielded four first-timers, including Saul Williams, who also stars in the fiction film "Slam," and Mums the Schemer, who plays the character Poet on the HBO prison drama "Oz." In evaluating the poetic content of the slams, one is tempted to take easy shots. (Poetry slams are to poetry as military music is to music?) Most of the material exists halfway between rap music and Vachel Lindsay. Slams are essentially performance art, not literary art, and there is a shot of a New York book editor, sighing at his stack of slam manuscripts and observing that sometimes the poems don't translate well to the printed page.
Maybe that's because "SlamNation," covering three semifinal rounds and the finals, inevitably focuses on the competition rather than the work. I have had one personal experience of slam-style poetry, and it was truly unforgettable.
Last April, at the annual meeting of the American Society of Newspaper Editors in Washington, D.C., the luncheon speaker was Secretary of State Madeleine Albright, who rattled off her speech as quickly as she could and hurried from the dais. Then the society's chairman called on a young woman to "give us one of your poems." This was Patricia Smith, a friend of mine from her Chicago days, then a columnist for the Boston Globe. She performed a poem about a visit to a grade school class at which she asked, "How many of you know some dead people?" Almost every hand went up, she said, because all of these inner-city children knew dead people--many of them dead from drugs and gunshots. At the end a little girl thanked her for saying it was all right to know dead people. The girl was speaking of her own murdered mother.
This summary fails to capture the impact of Smith's poem, which surprised me to tears. I looked around the room and thought I had rarely seen so few words have such a strong impact.
Pat Smith of course was soon to get publicity of a different sort, when her paper accepted her resignation after she confirmed that some details of her columns had been made up. Making things up is not what a journalist is supposed to do, but it is what a poet is supposed to do. Seeing Smith again in "SlamNation," as a member of the Boston team, I was reminded of the power of her words. She can see life and touch readers as few writers can. That is her vocation. Fiction and poetry exist to reach a different kind of truth. Maybe she had no business dealing with facts in the first place.
As for the other performers, I am prepared to believe that in context, uncut, seen as they should be, some of them have the same power. Others are basically soapbox orators with a new forum. In the cheerful anarchy of poetry slams, there is room for many styles. As a slammer named Jack McCarthy from Boston says, "You have to write one poem that everyone agrees is a poem. That qualifies you for your poetic license. After that, if you say it's a poem, it's a poem."
This message came to me from a reader named Peter Svensland. He and a fr...
An obituary for Wes Craven.
A piece on the response to the sexism in "Straight Outta Compton."
Scout Tafoya's Unloved series continues with Roland Emmerich's "Anonymous."


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CLEVELAND -- Moments after the Red Sox' 3-1 loss to the Indians Tuesday night, David Ortiz turned in his chair and pointed to the center of the clubhouse.
"It was right over there," the Red Sox DH said. "I called everybody out."
What Ortiz did was step into the center of the visitors dressing quarters at Progressive Field following the Sox' Game 4 defeat at the hands of the Indians in the 2007 American League Championship Series and exclaim (in his own colorful way) that anybody who wore the Red Sox uniform was a "bad [blankety-blank]."
The result was the Red Sox coming back to win Game 5, and then Game 6, and finally the entire series on the way to claiming a World Series championship.
So, were such tactics necessary once again? When in Rome, right?
Sure, it's just four games in, but in some fans' minds this situation seems every bit as dire as that one-game-from-elimination scenario four seasons ago. No Red Sox team has started a season 0-4 since 1995, and it never recovered the rest of the way.
"No," Ortiz said regarding the need for any speeches. "We'll be OK."
He elaborated, "When you're facing this kind of situation, you definitely want to get the first one out of the way. And keep on moving. That's how things get started. Everyone's trying. Probably some of us are trying a little too hard, but that's baseball. Things happen.
"You've got to just keep on playing. That's what I believe. That's why we don't have 17 games [as] in the NFL or 82 in the NBA. We've got 162 so you can figure things out, because this is a hard game to play. You've got to go day by day. Everyone tonight has to wipe their mind off and come back tomorrow.
"Everyone's got a great attitude. Everyone's coming down early and getting ready to play. Things just aren't happening right now."
The moral of the story thus far is this: Everybody understands that the Red Sox have the potential to be what Ortiz mandated all who wear the uniform be back in '07 -- bad blankety-blanks. And every player Tuesday night seemed as steadfast in the belief that their talent was going to ultimately win out as they did prior to playing in from 9,025 (the smallest collection of fans to watch a Red Sox game since 2000).
The problem is that they haven't found the key to unlock their inner-bad-blankety-blank-ness.
"There's too much history here," Josh Beckett said. "Everybody here knows how to win. We've got to figure it out. Nobody is going to come out of the blue and feel sorry for us and help us out. We know what we've got to do. We've got to go out and execute."
Beckett offered a perfect example of what the Red Sox are facing.
The Red Sox starter Tuesday night was the one who led the way in '07 in allowing Ortiz' words sink in, going out and dominating the Indians in Game 5. There was no bigger bad blankety-blank on the planet that night.
Talk to Beckett following his five-inning, three-run outing in the Sox' most recent loss and you still get the feeling he is on the verge of putting that cape back on. He's healthy. He has a pitch (the changeup) that has turned into a legitimate weapon (throwing it 27 times with an average velocity of 87 mph). And his stuff, while not as explosive as in the heat of Houston, hadn't disappeared.
But, right now, something is missing.
In a tangible sense, what was standing in the way of Beckett in his initial start of the season was the ability to locate when he needed to and not fall behind. But he didn't and he did. The result was a 35-pitch third inning, which was followed by frames of 23 and 24 pitches, respectively.
Beckett threw 27 of his 47 pitches in the final two frames out of the strike zone, falling behind in half his at-bats. He'll be the first to admit, that isn't the kind of stuff that is going to put a 'S' on your chest.
"Like I said last time, the adjustments that we made, they're becoming more easy for me to get to. I don't revert back to other things. That being said, you can't throw 100 pitches in five innings. You're not going to survive very long," he explained.
Beckett isn't alone.
This was supposed to be the lineup that tore up American League pitching like no other before it. Not happening.
The collection of excellence is hitting .186 (second-to-last in the majors), with the third-worst OPS (.565) in the big leagues. Of the starting nine, six are hitting .188 or worse.
After the latest loss, the hitters were suggesting they hadn't executed a Red Sox-style approach, jumping at too many early pitches from Cleveland starter Josh Tomlin. And they were right, seeing an average of 3.79 pitches per plate appearance to drop their majors-best average to 4.13 for the young season.
But, as they say, the first sign of addiction is denial, and at least this group admitted it was coming out of its identity.
"The guys that were here before, they've won," Red Sox second baseman Dustin Pedroia said. "The guys that we got have won. We all know how to win. you can't keep a good man down for long, that's about it."
Pedroia's right. But, through an angst-filled four games, something is keeping them down. It could be a major league-worst 8.16 team ERA. That aforementioned horrific team offensive production. Or perhaps the lack bravado, which has been siphoned somewhat by a litany of hard-to-digest numbers, most notably the four losses in as many games.
The Red Sox have to start showing they are the bad-blankety-blanks everybody had identified them as before being introduced to the regular season. Because if they don't, even Ortiz-esque reminders won't be enough.
"It's not a lot of fun," Francona said. "I don't think anyone is going to feel sorry for us. We just need to come out and just play the game right and things will work out. But if we feel sorry for ourselves, that won't help."
Butch and Price discuss how Belichick and the Pats manipulate the roster with cuts, injuries, practice squad etc. - it's a complicated subject! They then move on to the improving play of QB Jimmy Garoppolo. Butch and Price start salivating over the thought of regular season football being less than 2 weeks away and discuss some early intriguing matchups.
Butch is in for Dickerson on NFL Sunday and he and Chris get into the victory over Carolina and their take-aways - the receivers could be in trouble if they don't get healthy with Wayne struggling and Boyce not contributing at all, Scott Chandler is a beast that could be a huge redzone threat with Gronk on the field and more. They talk about the offense and break down the running back depth chart. Then Trags gives them a call to give his take on the roster and their play so far.
WEEI's Mike Petraglia and Chris Price discuss Reggie Wayne's arrival in New England and look at what he might be able to bring to the team.
Jay King of Masslive.com joins the show to break down the performance of the Celtics during the NBA Summer League. Then Ben and Sam discuss the exciting possibility of a Space Jam sequel.
Michael joins Ben and Sam to discuss the wild NBA Free Agency period and the upcoming Celtics season.
How long will this rebuild take? How much money will it take to keep Bae Crowder? Are Draft Picks even worth anything? With the Danny Ainge not landing any big names in the draft, and unable to lure any big names in free agency, Sam and Ben discussed if the Celtics are doomed moving forward.
Butch and John are talking Red Sox on the Sunday Sports Roundtable. They get into the current state of the rotation and how things have improved as of late. Joe Kelly has been on fire, but is he a trade asset? The guys discuss the starting pitchers that will be free agents this year and if any are good fits in Boston. Then they move on to the decision to let Orsillo go in favor of Dave O'Brien - Tomase has an interesting perspective on this topic.
Joe & Dave talked to the Sox starter, who pitched into the eighth inning and allowed just one run in the win over the Mets.
Joe and Dave talk with Red Sox catcher Blake Swihart, who hit his first career inside the park home run and propelled the Red Sox to a 6-4 win over the New York Mets.
Don Sweeney, who was hired as the Bruins general manager yesterday speaks with Dale and Holley about his new position and where the Bruins go from here.
The awesomely knowledgeable Fluto Shinzawa calls DJ, Naoko and Pete to talk about his thoughts on the future of the B's. He discusses his column from earlier this week on Cam Neely wanting to give Claude the ax earlier in the season but not getting the ok. Fluto shares his thoughts on Chiarelli's firing, the future for Claude and where the Bruins should go from here. He also gives his opinion on potential moves the team can make, who would fit in here, his thoughts on the NHL playoffs so far and more.
In the final hour of the "midseason finale" as DJ likes to call it, the crew discuss more about the future of the Bruins franchise, the possible power struggle in the front office and who should be the head coach going forward. They talk to intelligent and talented Fluto Shinzawa about all of these thing and more in an excellent interview, and finally, DJ says THANK YOU!
Another hour of Mort being wrong.
Callers reacted to another mistake by Mort.
The great Mike Florio of Pro Football Talk joined us on the latest Mort screw up.
The guys discuss some possible headlines come Pats opening night and talk about the reception that Roger Goodell might get if he's in Foxboro.
On the brink of the Pats' third preseason game, Christian kicks around some players that we might see suit up tonight in Charlotte.
The guys discuss a number of off-topics that are in the news today, including Sir Charles calling out his former agent, a Texas little league coach gives a pre-game talk for the ages & Jay Gruden is becoming sensitive.
We wrap up the week with the best in sound that you may have missed, plus our intern on the mic Laroy Streat has some well-wishes for the birthday boy Jerry Thornton.
We discuss the infamous apologies, and how a little humble pie could have ended this entire Chris Mortensen misreporting mess way sooner.
We talk some Sox, including all things Hanley Ramirez.
Chris Mortensen went on a sports radio station in Arizona today and talked about his deflate gate reporting, and said that the Krafts called him to apologize over the whole situation. Only thing is there's a report tonight from D&C saying their sources at the Patriots are saying that did not happen, could Mort be, dare I say, wrong?
Chris Villani and Lenny Megs talk with Bob McGovern about the proceedings in the Tom Brady and NFL's deflate gate court case.
Villani is in for Mikey, he's talking about Chris Mortensen going on an Arizona station and talking about deflate gate and getting an apology from the Krafts.
It's peek draft season so Jim Hackett and Pete Davidson are back with today's Fantasy Football Podcast on Draft Strategy. Pete Davidson's article at Rotobahn.com "The 2015 Draft Plan" fuels a deep conversation on how to approach the draft at all the key positions Quarterback, Runningback, Wide Receiver, Tight End and Defense. Get prepared and Happy Drafting!
Ben, Russ & Alex discuss their favorite transfer moves of the window, Alex shares his dislike for Arsenal manager Arsene Wenger and just how far can the Revs go this season?
Gerry and Kirk discuss deflategate and the Patriots relationship with ESPN.
Dale, Thornton and Dickerson discuss and find many problems with Lester Munson and his latest article.More from this show
The guys discussed the news surrounding the Sox play by play announcer.More from this show
We go inside the audio from 98.7 Arizona Sports Radio/ESPN and listen in as well as Chris Mortensen finally details the circumstances behind the infamous "11 of 12" footballs tweet, and also claims that the Patriots ownership called him personally to apologize... for what he doesn't specify.More from this show
Sean discussed his own firing from the Red Sox broadcast booth.More from this show
Callers reacted to another mistake by Mort.More from this show


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Mark Henry Update, McMahon Supporting Romney, Website Rips CM Punk
by Amish Patel - May 11, 2012
– We noted before that Mark Henry was pulled from last weekend's RAW live events and wasn't at this week's TV tapings. Henry was apparently in Austria as he visits the Arnold Schwarzenegger museum in the latest episode of WWE's Outside the Ring:
– Conservative website BreitBart.com has published an article about CM Punk's Twitter comments on Monday supporting Amendment 1 in North Carolina and subsequent tweets where he told a user to "kill yourself," and another to "drink bleach." The site called Punk "another Dan Savage-style eloquent spokesperson for the same-sex marriage cause."
The site did not mention Punk's apology later that evening.
– CNN.com has an article about George Clooney's fundraiser dinner for President Obama tonight and celebrities who are supporting the President. The article noted that Republican presidential hopeful Mitt Romney didn't have as many celebrity supporters, but was able to secure donations from producer Jerry Bruckheimer and WWE CEO Vince McMahon.
The Hottest WWE news, photos and videos delivered to your inbox in one convenient newsletter. Sign up now and give it a try!
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World - Most Recent
Poker is no gamble
Jul 29, 2005
Pro poker player Clonie Gowen talks to Lisa Napoli about the business of the game, and what it's like being the lady at the table. Web special: click through for an extended interview with Clonie.
Honda's new business jets
Jul 29, 2005
Honda's latest offering goes quite a bit faster than 55mph. The company says its new jet engines get the best mileage in the air. Jason Paur reports.
To swoosh or not to swoosh
Jul 29, 2005
Diana Nyad talks with host Kai Ryssdal about Nike, sports marketing, and Lance Armstrong and Andre Agassi.
Got your eye on some property?
Jul 28, 2005
If you haven't dipped your toe in the real estate waters lately, the temperature's still rising. Some Americans are heading south for some action. As far, Dan Grech reports, as Costa Rica. From our Americas Desk at WLRN, Dan Grech reports.
A Coke by any other name
Jul 28, 2005
Sales of sugary sodas have been flat for years. But now, some new products are making earnings pop at Coca-Cola Enterprises. Janet Babin examines whether it will be enough to sustain the industry.
Did ya hafta go for CAFTA?
Jul 28, 2005
Chris Farrell tells Kai Ryssdal what he thinks of the free trade agreement passed by Congress last night.
New Jersey and the Sudan
Jul 28, 2005
Today New Jersey's acting governor Richard Codey will sign a bill that cuts all financial ties between Trenton and Khartoum. Jeff Tyler reports on the move to divest following atrocities in the Sudan.
A new star for hockey
Jul 28, 2005
Lisa Napoli talks with David Carter about hockey's hope for a starry Christmas — it's a Crosby, all right, but not Bing. Instead, meet young Sidney Crosby.
Bye bye employee discount
Jul 27, 2005
You knew it couldn't last forever. Starting August 1 the only people getting the General Motors employee discount will be its employees. Amy Scott reports.
A cleaner way to clean up
Jul 27, 2005
There is a way to treat heroin addiction without the ugly side effects of methadone — it's just not accessible. David Brown talks to reporter Douglas McGray.


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Palestinians in Gaza speak of life under Israeli occupation.
"The Islam of Timbuktu was taken hostage"
12 Dec 2013 20:40 GMT | Environment, Humanitarian crises, Middle East, Syria, Turkey
Severe snow storms have delayed the UN's airlift of emergency supplies into parts of Syria. It will be at least another two days before they can move the supplies to provide relief for tens of thousands of people. Al Jazeera's Anita McNaught reports from Istanbul, in neighbouring Turkey.
Source: Al Jazeera
Rain, strong winds and even snow face those fleeing the conflict in Syria.
Many families living in flimsy shelters are ineligible for help because they are not registered with the UN.
Environment, Humanitarian crises, Middle East, Lebanon
Critics cry foul as production exploring youth radicalisation mysteriously pulled after police visit.
Censorship, United Kingdom, Human Rights
Calais is the most visible sign of France's refugee influx, but smaller camps scattered across the north are growing.
Refugees, Human Rights, War & Conflict
Medicine finally joins religious therapy for thousands suffering psychological disorders in southern Tamil Nadu state.
Mental health, Religion, Poverty & Development
Facing sanctions and stigma, Iranian Americans are pushing for the nuclear deal to survive Congress' September vote.
Politics, Iran, United States
About 1,000 gather outside Budapest railway station, with many heard shouting "Germany, Germany," where they want to go.
Refugees, Europe, Hungary, Austria, Germany
Dozens of protesters occupy environment ministry over rubbish crisis, refusing to leave until the minister resigns.
Lebanon, Middle East, Politics
From the fiction of Nollywood to the reality of Nigerian politics, movie star Kate Henshaw wants to make a difference.
Arts & Culture, Africa, Nigeria
We look at the micro-blogging site and how it has changed the way breaking news is reported.
Media, United States, Twitter
People & Power investigates South Korea's disturbing rise in suicides, particularly among the elderly.
Health, Asia, South Korea
We explore how US foreign policy in the Middle East is driving the media's negative portrayals of Arabs and Muslims.
Media, Middle East, US


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An app to help people in Jakarta beat the traffic has apparently been downloaded faster than any other app in the country's history
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19 Aug 2015
Sydney: If you love to include chillies in your diet, you have another healthy reason to do so. According to a study, consumption of hot chillies can prevent overeating via an action on nerves in the stomach, thus curbing obesity in chilli lovers.
20 Aug 2015
Islamabad: Indian Prime Minister Narendra Modi's visit to the UAE should be a wake-up call for Pakistan as "India is on the move in the region", said a leading Pakistani daily on Thursday.
04 Aug 2012
Veteran CPI leader and champion of women's rights Bani Dasgupta died on Saturday, family sources said. She was 88.
30 Jul 2015
New Delhi: Smartphone users in the country spend an average 169 minutes (about three hours) per day on their devices, a report by mobile advertising company Vserv said today.
23 Jul 2015
Ottawa: Spending more than two hours daily on Facebook, Twitter or Instagram can put your kids at the risk of developing poor mental health, high psychological distress and even suicidal thoughts, new research shows.
17 Jul 2015
New York: With Facebook already clocking four billion daily video views, it is clearly one of the fastest growing content categories on the site.
07 Jul 2015
Singapore: If you are not sure about how to curb excess drinking, then download this app that will warn you the moment you exceed your daily alcohol limit. The app 'The Alcohol Tracker,' enables users to log the number of beers, shots or glasses of wine they are either prescribed or can handle daily or weekly.
19 Jun 2015
New York: If you are looking for a simple strategy to become slim, then start stepping on a scale each day and track the results, a new study says. In a study spanning over two years, researchers found that self-weighing and tracking results on a chart were effective for both losing weight and keeping it off, especially for men.
16 May 2015
London: Just 30 minutes of physical activity six days a week is linked to a 40 percent lower risk of death from any cause among the elderly, a new research shows.
11 May 2015
Chandigarh: Concerned over delay in crop lifting and payment to farmers, Punjab government on Monday asked all purchasing centres in the state to send daily report on procurement operations.


text: A stylish B&B, with a central location. We stayed for two nights and found the atmosphere warm and friendly. The room was well equipped with everything we needed, including special touches like bathrobes, guidebooks, and electricity convertors. Overall we enjoyed our stay and would highly recommend stay at the Inn Old Amsterdam.


text:
|By Udayan Banerjee
Article Rating:
|September 19, 2012 12:30 PM EDT
The answer is…
…all three are "lightweight".
…all three were a result of fresh ground up thinking.
…all three had drastically simplified the existing way of doing things.
Quick look at their evolution
1972: Most commonly used languages (Cobol, Fortran, Algol, PL/1, Basic, APL) all had complicated syntax. The prevailing thought process was to add new language syntax for every new feature. Writing a compiler for such languages was a nightmare.
Then came "C". The syntax was simple and could easily be parsed. Compiler could be lightweight. Every additional feature were added though a function library. This was a paradigm shift. Syntax of most popular languages (Java, C++, C#, JavaScript) are C like.
2001: The focus was on formal, well specified software development processes. You had SSAD, OOAD, and RUP. SEI had just released its CMM framework.
Then came the "Agile Manifesto". Over a period of time agile processes started getting adopted everywhere. Every organization is having a serious look at agile and even SEI and PMI wants to coexist with agile methods.
2009: Web servers and App servers have been maturing. Features of SOA and ESB were getting incorporated. The footprint was getting larger and larger.
Then came "node.js". It was a simple and light weight framework which could be used as a very lightweight webserver. It used non-blocking I/O. So the memory occupancy was drastically reduced. Adoption has already started. Only time will tell if it will have the same level of impact as "C" and "Agile".
Three Laws of Success
- Success leads to complexity aimed at maintaining status quo
- Such complex systems cannot simplify itself
- It takes a revolution from outside to break the status quo
Some complex system fails like General Motors filed for bankruptcy in 2009.
Others like IBM reinvented itself.
The pages of history are littered with similar happening – here are 3 examples.
Alexander the Great, Prophet Mohammad and Genghis Khan
4th Century BC: Greece consisted of Athens and Sparta. Outside Greece you had Carthage, Persian Empire, Egypt etc. Macedonia was nowhere in the picture. Roll forward less than a century – Alexander the great of Macedonia was the emperor of the largest empire of that time.
600 AD: The world consisted of the Byzantine Empire in Europe & North Africa, Sassanid Dynasty in Persia & Middle East and Gupta Empire in India. Arabia, Mecca and Medina had not taken any part in history. Advance the history by couple of centuries – you see The Abbasid Caliphate was ruling the Middle East, North Africa and Southern Europe. Cordoba in Spain had become the most prosperous city of Europe.
1200 AD: There were many kingdom scattered around the world. Some like the Song Dynasty of China was at the peak of its glory. Others like Abbasid Sultanate were on decline. But, Mongolia had not taken any significant part in world history but all that was about to change. A century later, Genghis Khan and his descendants had established the largest connected empire the world has ever known.
Is there any lessons that we can learn from these examples?
Read the original blog entry...
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text:
Taurine: new implications for an old amino acid
Taurine is a semi-essential amino acid and is not incorporated into proteins. In mammalian tissues, taurine is ubiquitous and is the most abundant free amino acid in the heart, retina, skeletal muscle, brain, and leukocytes. In fact, taurine reaches up to 50 mM concentration in leukocytes. Taurine has been shown to be tissue-protective in many models of oxidant-induced injury. One possibility is that taurine reacts with hypochlorous acid, produced by the myeloperoxidase pathway, to produce the more stable but less toxic taurine chloramine (Tau-Cl). However, data from several laboratories demonstrate that Tau-Cl is a powerful regulator of inflammation. Specifically, Tau-Cl has been shown to down-regulate the production of pro-inflammatory mediators in both rodent and human leukocytes. Taurolidine, a derivative of taurine, is commonly used in Europe as an adjunctive therapy for various infections as well as for tumor therapy. Recent molecular studies on the function of taurine provide evidence that taurine is a constituent of biologic macromolecules. Specifically, two novel taurine-containing modified uridines have been found in both human and bovine mitochondria. Studies investigating the mechanism of action of Tau-Cl have shown that it inhibits the activation of NF-κB, a potent signal transducer for inflammatory cytokines, by oxidation of IκB-α at Met45. Key enzymes for taurine biosynthesis have recently been cloned. Cysteine sulfinic acid decarboxylase, a rate-limiting enzyme for taurine biosynthesis, has been cloned and sequenced in the mouse, rat and human. Another key enzyme for cysteine metabolism, cysteine dioxygenase (CDO), has also been cloned from rat liver. CDO has a critical role in determining the flux of cysteine between cysteine catabolism/taurine synthesis and glutathione synthesis. Taurine transporter knockout mice show reduced taurine, reduced fertility, and loss of vision due to severe apoptotic retinal degeneration. Apoptosis induced by amino chloramines is a current and important finding since oxidants derived from leukocytes play a key role in killing pathogens. The fundamental importance of taurine in adaptive and acquired immunity will be unveiled using genetic manipulation.
- Taurine
- Taurine chloramine
- Inflammatory mediator
- Nitric oxide
- Tumor necrosis factor α
- Cysteine sulfinic acid decarboxylase
- Taurolidine
1 Introduction
Taurine, a sulfur-containing amino acid present in high concentrations in mammalian plasma and cells, plays an important role in several essential biological processes such as development of the central nervous system (CNS) and the retina, calcium modulation, membrane stabilization, reproduction, and immunity [1–3]. In fact, taurine is the single most abundant amino acid in leukocytes (20–50 mM) [4]. Taurine, although not incorporated into proteins, is considered to be an essential amino acid for felines and a conditionally indispensable amino acid for humans and non-human primates [2]. The level of cysteine sulfinic acid decarboxylase (CSD), an enzyme required for biosynthesis of taurine, is very low in the cat and low in humans and primates. For this reason, taurine has been added to infant formula as well as to parenteral solutions. Taurine occurs naturally in food, especially in seafood and meat. The mean daily intake from omnivore diets was determined to be around 58 mg. Taurine-containing health drinks, usually containing about 1 g of taurine, are marketed worldwide for the treatment of various conditions, for improvement of athletic performance and for general well being [5]. Animal studies have not indicated toxicity due to taurine. In light of recent evidence on the role of taurine in immunity, risk assessment studies on the effect of these drinks in immunocompromised patients, children, and pregnant women should be performed.
2 Taurine and taurolidine as adjunct therapy for infections, endotoxemia, and tumors
Several recent papers describe the role of taurolidine (Geislick Pharma, AG, Woljusen, Switzerland) in infection [6]. Taurolidine is a derivative of taurine and is commonly used in Europe, the UK, Ireland and the USA as adjunctive therapy for various infections. Taurolidine is chemically designated as bis-(1,1-dioxyperhydro-1,2,4-thiadiazinyl-4) methane and consists of two taurolidine rings derived from taurine and three molecules of formaldehyde combining to form a two-ringed structure bridged by a methylene group [6]. Taurolidine, which is stable, has a short half-life, is non-toxic, metabolizes to taurine, CO2 and H2O, and irreversibly inactivates lipopolysaccharide (LPS). Recent reports include anti-endotoxin, anti-bacterial, and anti-adherence activities for taurolidine. Taurolidine is now included in a new catheter lock solution (Neutrolin; Biolink, Norwell, MA, USA) to prevent catheter-related infections. Bedrosian et al. [7] attribute the activity of taurolidine to blocking the production of interleukin (IL)-1 and tumor necrosis factor (TNF). Taurolidine may have anti-bacterial action that is independent of the resultant taurine metabolites. While both taurine and taurolidine can down-regulate inflammation, it is unclear whether taurine is anti-bacterial and would be useful in a serious infection. Tissue damage could be minimized by taurine's anti-inflammatory properties, but a possible lack of anti-microbial function, associated with enhancement of macrophage and polymorphonuclear leukocyte (PMN) proinflammatory activity, would be detrimental to elimination of pathogens.
In studies by De Costa et al. [8] taurolidine enhanced survival in an animal model of melanoma. Natural killer cells and lymphocyte-activated killer cells were functional in the taurolidine-treated group compared to untreated animals with melanoma, perhaps accounting for the increased survival in the treated group. Taurolidine also inhibited the growth of a rat metastatic colorectal tumor cell line in vitro and in vivo [9]. These studies suggest that taurolidine may have value in management of patients with tumors. Egan et al. [10] have shown in sheep that taurolidine had a therapeutic role in preventing endotoxin-induced lung injury. In this model i.v. taurine (300 mg kg−1), given 1 h before i.v. endotoxin, significantly reduced lung injury.
Although reports of decreased plasma levels of taurine in trauma, sepsis and critical illness are available, very little is known about the relationships among changes in plasma taurine, other amino acid levels, and metabolic variables. A large series of plasma amino acid profiles were obtained in 250 trauma patients with sepsis who were undergoing total parenteral nutrition [11]. The results, which characterized the relationships between plasma taurine and other amino acid levels in sepsis, provide evidence that the more severe decreases in plasma taurine correlate with the worsening of metabolic and cardiorespiratory patterns.
3 Immunologic consequences of taurine deficiency versus supplementation
For cats and primates, deficiency of dietary taurine results in abnormalities in development of the CNS, retinal and tapetal degeneration, as well as significant changes in the cardiovascular and reproductive systems. These changes are also accompanied by abnormalities in the immune system [3]. A lack of taurine in the diet of cats resulted in a significant leukopenia, a shift in the percentage of polymorphonuclear and mononuclear leukocytes, an increase in the absolute count of mononuclear leukocytes, and a change in the sedimentation characteristics of white cells. Functional studies of polymorphonuclear cells isolated from cats fed taurine-free diets demonstrated a significant decrease in the respiratory burst as measured by chemiluminescence as well as a decrease in phagocytosis of Staphylococcus epidermidis compared to cats fed the same diet containing taurine. In addition, serum γ-globulin in cats fed taurine-free diets was significantly increased compared to taurine-supplemented cats, indicating that other immune cells may be affected by taurine deficiency. Histological examination of lymph nodes and spleen revealed regression of follicular centers with depletion of reticular cells, mature and immature lymphocytes as well as mild extravascular hemolysis [3]. These results indicate there are profound immunologic abnormalities in cats with prolonged taurine deficiency.
Reports indicate an increased incidence of pediatric problems in children from vegan communities that eat little to no taurine [12]. These problems are usually attributed to malnutrition but a role for immunologic and other consequences of taurine deficiency cannot be ruled out.
Taurine is found in particularly high concentrations in tissues exposed to elevated levels of oxidants. Several in vivo models of oxidant-induced damage have been studied using taurine as a protectant against inflammation. Hamsters pretreated with supplemented dietary taurine and then exposed to NO2 did not show morphological alterations typical of NO2 damage [13]. Wang et al. [14] demonstrated that taurine and niacin reduced the inflammation and fibrosis caused by bleomycin. This group also reported that taurine and niacin blocked the bleomycin-induced increased production of nitric oxide in bronchoalveolar lavage fluid, as well as the overexpression of iNOS mRNA and NOS protein in lung tissue [15]. Rats treated with guanidinoethanesulfonate, which is a competitive inhibitor of taurine binding and transport and depletes cellular taurine levels, showed enhanced lung pathology after treatment with both bleomycin and paraquat [16]. Thus, maintenance of tissue taurine levels was critical to the prevention of oxidant-induced lung injury.
We performed studies to determine if ozone-induced lung inflammation was modified by pretreatment of 5% taurine in the drinking water for 10 days prior to ozone (O3) exposure (2 ppm for 3 h). The number of inflammatory cells and hydroxyproline levels in the bronchoalveolar lavage of taurine-treated rats was significantly reduced compared to untreated rats exposed to O3[17]. Light microscopy revealed a significant inflammatory infiltrate in the lungs of rats 48 h after exposure to O3 followed by focal hyperplasia in the terminal and respiratory bronchioles (72 h) (Fig. 1). Rats pretreated with taurine in the drinking water for 10 days and then exposed to O3 showed none of these alterations (Fig. 1). These results show that supplemental taurine protects rats from acute ozone-induced lung inflammation and hyperplasia.
Bleomycin-induced lung injury results in dysregulated matrix remodeling, leading to thickened alveolar walls, alveolar collapse and scarring [18]. Fibrosis culminates in the overproduction of interstitial collagen. Fibrosis is strikingly absent and inflammation is reduced in the lung of rats pretreated with 5% taurine in the drinking water for 10 days prior to bleomycin instillation [18]. Significantly more intercellular adhesion molecule (ICAM) was demonstrated in the bleomycin-treated group compared to the taurine-treated bleomycin group, indicating that ICAM correlated with lung damage. Those cells which do enter the lung in the taurine-treated group do not appear to 'stick and stay' which may be one mechanism for the absence of fibrosis in this group.
Other evidence supporting the 'stick and stay' idea is the data of Abdih et al. [19] and Egan et al. [20]. Abdih et al. [19] demonstrated that taurine prevents IL-2-induced acute lung injury, in part, by decreasing neutrophil interactions. Data from Egan et al. [20] demonstrate that following administration of LPS there was an increase in leukocyte rolling accompanied by an increase in the number of adherent leukocytes and transendothelial migration. Taurine given orally as a 4% solution significantly attenuated the LPS-induced leukocyte rolling and attenuated the number of adherent leukocytes as well as the increase in transendothelial cell migration.
Our hypothesis is that supplemental taurine in the drinking water increases the available taurine both systemically and at the site of inflammation. Leukocytes capable of generating hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride via the myeloperoxidase (MPO) pathway have intracellular concentrations of taurine of 20–50 mM. Moreover, in physiologic fluid extracellular taurine concentrations range from 50 to 100 mM after taurine supplementation [21]. Taurine reacts with HOCl to produce the less reactive and long-lived oxidant taurine chloramine (Tau-Cl). Thus, Tau-Cl, a stable oxidant, can be produced at the site of inflammation and down-regulate proinflammatory cytokine production leading to a significant reduction in the immune response. Taurine may provide a useful prophylactic approach to preventing tissue damage resulting from inflammation.
4 Taurine chloramine, the 'active' product of taurine, and the MPO pathway
Neutrophils and monocytes contain high levels of MPO, which, along with H2O2, catalyzes the formation of the potent oxidant, HOCl. Taurine, the most abundant free amino acid, scavenges HOCl to form the more stable and less toxic Tau-Cl [22,23].
Tau-Cl inhibits in a dose-dependent manner the production of both NO and TNF-α by activated RAW 264.7 cells, a macrophage-like cell line (Fig. 2) [24]. Tau-Cl (0.8 mM) inhibited secretion of TNF-α into the media and nitrite production from activated RAW 264.7 cells by 65% and 91%, respectively. To examine the mechanism(s) whereby Tau-Cl inhibits inflammatory cytokines, activated cell lysates in the presence or absence of Tau-Cl were analyzed for the inducible form of NO synthase (iNOS) by Western blot analysis, and TNF-α and iNOS mRNAs were assessed by Northern blot analysis [25]. Western blot analysis showed that iNOS protein was absent from cells activated with LPS and rIFN-γ in the presence of 0.8 mM Tau-Cl. Northern blot analysis demonstrated that Tau-Cl (0.8 mM) significantly inhibited iNOS mRNA at all time points examined (Fig. 3) demonstrating that Tau-Cl inhibits transcription of the iNOS gene. In the same experiments, Tau-Cl delayed the peak expression of TNF-α mRNA from 4 h to 8 h, with continuing expression of high TNF-α transcripts after 24 h of activation. TNF-α secreted into the medium was inhibited by the same doses of Tau-Cl used in the Northern blot experiments, indicating that although TNF-α mRNA is present, translation of this message is impaired. The effects of Tau-Cl are not a result of either changes in viability (data not shown) or a generalized effect on gene transcription because α-actin mRNA was intact with treatment of Tau-Cl (see Fig. 3 for increase in TNF-α message).
Studies on Tau-Cl have been performed using macrophage cell lines and activated murine and rat macrophages. Recent studies have demonstrated that Tau-Cl suppressed superoxide anion, IL-6 and IL-8 production in activated human peripheral blood PMNs [26]. In addition, using both adherent and non-adherent leukocytes, many proinflammatory mediators were significantly decreased by Tau-Cl [27]. Choray et al. have confirmed and extended these finding using LPS-stimulated peripheral blood monocytes from humans [28].
Early administration of Tau-Cl resulted in the delay of the onset of collagen-induced arthritis (CIA) in DBA1/J mice [29]. This is the first study to use Tau-Cl in vivo for immune intervention. An analysis of genes involved in the inflammatory process of joints in DBA1/J mice with CIA was performed using microarrays [30]. Of the 11,000 genes assayed, 223 increased four-fold or more. Nine genes mapped to the chromosome contributing to susceptibility to CIA, including the taurine transporter gene.
Kontny et al. [31] have shown that Tau-Cl inhibits the production of proinflammatory cytokines (IL-6 and IL-8) by fibroblast-like synoviocytes isolated from rheumatoid arthritis patients. In these studies Tau-Cl diminished the activity of NF-κB and to a lesser extent, that of AP-1 transcription factor. This possible mechanism for down-regulation of proinflammatory cytokines was also demonstrated by Barua et al. (see Section 5) [32].
Marcinkiewicz et al. found that treatment of T-cells with Tau-Cl prior to activation inhibited IL-2 release in response to both mitogen and antigenic stimulation [33]. In addition, this group found exposure of dendritic cells to Tau-Cl affected their ability to stimulate T-cell responses. The authors suggest that Tau-Cl may favor the development of a Th1 rather than a Th2 response.
5 Recent molecular studies on the function of taurine and its chloramine
Taurine has thus far not been found as a component of a protein or nucleic acid and its precise biochemical mechanism(s) are unclear. Exciting studies from Suzuki et al. [34] demonstrate the first reported evidence taurine is a constituent of biologic macromolecules, which is a significant new insight into the function of taurine. They identified two novel taurine-containing modified uridines (5-taurinomethyluridine and 5-taurinomethyl-2-thiouridine) in human and bovine mitochondrial tRNAs. These nucleotides are synthesized by a direct incorporation of taurine supplied to the medium. They found an absence of taurine modified mitochondrial uridine in the cells from the mitochondrial diseases MELAS and MERRF. These findings will hopefully lead not only to development of therapies for these diseases but to clues for understanding an important biochemical function of taurine.
Barua et al. [32] have demonstrated that Tau-Cl depressed NF-κB migration into the nucleus of activated NR8383 cells, a cloned cell line derived from rat alveolar macrophages, and caused a more sustained presence of IκB in the cytoplasm. In additional experiments, Tau-Cl did not directly inhibit IκB kinase (IKK) activity suggesting that Tau-Cl exerts its effects at some level upstream of IKK in the signaling pathway.
Kanayama et al. [35] report Tau-Cl-induced inhibition of NF-κB activation by the oxidation of IκB-α. Deletion experiments showed that the Tau-Cl modification site causing the band shift is Met45, indicating that Met45 oxidation is a molecular mechanism underlying the Tau-Cl-induced inhibition of NF-κB.
6 Genetic studies on CSD, taurine transporter, and CDO
CSD was first identified in the liver as a rate-limiting enzyme in the biosynthesis of taurine. Reymond et al. [36] demonstrated that in addition to liver and kidney, rat brain expressed CSD mRNA. Brain CSD was strictly localized in glial cells, especially astrocytes, introducing a possible role of taurine in astrocyte–neuron interaction. Reymond et al. [36] and Kaisaki et al. [37] reported a sequenced CSD cDNA in the rat (GenBank accession numbers: X94152 and M64755, respectively). Human CSD has been registered in the GenBank (accession number: AF116548). Since the mouse is a good animal model for studies on the role of taurine in the immune system, we cloned murine CSD cDNA and examined the expression of CSD mRNA in various murine tissues including leukocytes. The cDNA sequence of murine CSD, which is a polypeptide of 493 amino acids (Fig. 4) [38], has 98% and 90% sequence homology of amino acids with rat and human CSD, respectively, indicating that it is a true ortholog of CSD. Northern blot analysis revealed that CSD mRNA is expressed in kidney and liver, and was not detected in lymphoid tissues and lung. These data suggest that lymphoid tissue may rely on transport of taurine and may not synthesize taurine directly.
Another key regulatory enzyme for cysteine metabolism is cysteine dioxygenase (CDO, EC 184.108.40.206) cloned from rat liver [39]. The levels of CDO activity changed by dietary protein level, in addition to cysteine availability, are key factors in determining the flux of cysteine between cysteine catabolism/taurine synthesis and glutathione synthesis [40]. Excess sulfur amino acids or protein increase CDO activity and CDO protein but not the levels of mRNA CDO. This suggests that CDO regulation may be posttranslational and possibly involve a decrease in the rate of CDO degradation.
To maintain adequate level of taurine in the tissues, taurine is tightly regulated by excretion and reabsorption by the kidney [41]. The taurine transporter in proximal tubule brush border membranes appears to be the primary target for adaptive regulation by dietary availability of taurine. The genes encoding the taurine transporter (TauT) for various species and tissues share a high degree of homology. TauT gene is located on the central region of mouse chromosome 6 and on human chromosome 3p21–25, where a conserved linkage group of genes has been found between mouse and man [42]. In patients with 3p syndrome, deletion of 3p25–pter is associated with profound growth failure, characteristic facial features, retinal changes and mental retardation, suggesting that deletion of TauT might contribute to some phenotypic features of the 3p syndrome [43].
Heller-Stilb et al. [44] have developed a mouse model with a disrupted gene encoding the taurine transporter (trans−/− mice). These mice show markedly decreased taurine levels in a variety of tissues, reduced fertility, and loss of vision due to severe retinal degeneration. A decrease of taurine concentration by 74% was observed in plasma, kidney, liver, and the eye. In skeletal muscle and heart, taurine levels were decreased by >95%. No data were reported for cells or organs of the immune system. The retinal involvement identifies the taurine transporter as an important factor for the development and maintenance of normal retinal functions and morphology. This progressive retinal degeneration was found to be caused by apoptosis. Han et al. [45] have shown that the taurine transporter gene is a transcriptional target of p53, which functions as a cell cycle checkpoint or may trigger apoptosis in cells with defective genomes. Of particular interest are the findings of Englert et al. [46] which show that amino chloramines induced apoptosis. Using B-cell lymphoma cells, Englert et al. have shown that long-lived aminoacyl chloramines (Tau-Cl being the most abundant) mediate HOCl-induced apoptosis. Since Tau-Cl is formed at the site of inflammation, neutrophil cell death and neutrophil-induced death at the inflammatory site would likely be apoptotic. Apoptotic cell death, in contrast to necrotic cell death, is a physiologic advantage in that cells are cleared by phagocytosis lessening tissue damage. Tau-C1 may promote apoptotic cell death and thereby decrease the detrimental effects of inflammation.
7 Taurine research: new insights
The schematic (Fig. 5) incorporates our findings as well as those of others on the possible mechanism(s) of action of taurine as an immunomodulator and as a component of RNA. Taurine has been shown to be tissue-protective in many models of oxidant-induced injury. Early events in inflammations include migration of leukocytes to the site of injury. These inflammatory cells produce high levels of HOCl via the MPO pathway and the abundance of taurine assures the production of Tau-Cl. Data show that Tau-Cl can be actively transported into leukocytes and can down-regulate the production of inflammatory mediators. New areas of research should extend these studies to include applications to clinical problems such as autoimmune diseases and inflammation. Two such areas include genetic manipulation of CSD, CDO and TauT which provide an approach to the fundamental roles of taurine in the immune system, CNS, reproduction and osmoregulation, as well as studies on the two novel taurine-containing modified uridines in human and bovine mitochondrial tRNAs.
We thank Ms. Vanessa DeBello for secretarial help and William R. Levis, MD for reviewing the manuscript. The Office of Mental Retardation and Developmental Disabilities and USPHS Grant HL-49942 provided funding for this work. We apologize to those whose papers were not cited because of the publisher's space limitations.
- © 2003 Federation of European Microbiological Societies


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Palestinians in Gaza speak of life under Israeli occupation.
"My Nigeria is my earth, my material, my jokes"
01 Sep 2013 13:10 GMT | Politics, Business & Economy, Asia Pacific, Malaysia
Malaysia's once robust economy is feeling the effects of Asia's economic downturn.
Ratings Agency Fitch has revised the country's outlook from stable to negative, and the central bank has downsized its growth forecast for this year.
Corruption is a big concern. Experts say if the government truly wants to solve its debt problems, it should start by stopping waste of money through overspending on government projects and introducing transparency in spending.
Al Jazeera's Stephanie Scawen reports from Kuala Lumpur.
Source: Al Jazeera
Hope and scepticism abound after government vows to tackle endemic graft that continues to anger ordinary Malaysians.
Politics, Indonesia, Latvia, Malaysia, Philippines
Three people detained on sedition charges as police launch crackdown on dissent.
Politics, Asia Pacific, Malaysia
Thanks to an innovative relocation programme, the Alameens' lives have changed dramatically after fleeing the war.
Refugees, Germany, Syrian crisis
After extending air war against fighters in Iraq, London contemplates military targets in Syria as well.
War & Conflict, United Kingdom, Middle East
Monsoon storms have wreaked havoc on Myanmar's persecuted Rohingya Muslims.
Rohingya, Human Rights, Weather
Critics lament New Delhi's fading pro-Palestinian stance at solidarity convention as Israel relations flourish.
Palestine, India, Gaza: After the war
Austrian police confirm final death toll, saying the refugees included eight women and four children.
Refugees, Politics, Europe, Mediterranean, Austria
Officials say 82 dead and at least 100 missing after boat sinks off Libyan coast in latest in series of disasters.
Humanitarian crises, Human Rights, Africa, Europe, Refugees
People & Power investigates South Korea's disturbing rise in suicides, particularly among the elderly.
Health, Poverty & Development, South Korea
A story of political skulduggery in Yemen and the high cost to the presidency of alleged collusion with the Houthis.
War & Conflict, Politics, Yemen
South Sudan's president talks about the ongoing violence, internal rivalries, and the future of his country.
Politics, South Sudan, Sudan
The comedian gives an insight into his street-smart Nigerian life as he gets his act together and grows his brand.
Arts & Culture, Africa, Nigeria


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Goodbye, "witch's house"
No Milwaukee high school experience, including my own, was complete without a trip or two to the "witch's house."
At the time, I knew little about the house, other than it was a lakeside cottage in Fox Point with a yard surrounded by barbed wire and packed with whimsical and spooky sculpture.
I would later find out about (and fall in love with) the creator of the art, Mary Nohl, who lived there until her death in 2001.
At some point, I stopped calling the funky cottage "the witch's house" and, instead, referred to it as "Mary Nohl's house." Nonetheless, I was honored to be a part of Joe Skow's 2012, 20-minute documentary "Pilgrimage To the Witch's House."
News emerged today that the John Michael Kohler Arts Center, which owns the home and its contents, will dismantle the house this summer and rebuild it in the Sheboygan area.
Both through word of mouth and personal experience, I learned that the neighbors were not fans of the house because of the traffic it drew to the suburban, residential neighborhood.
Hence, it's no surprise that these neighbors were uninterested in agreeing to the zoning changes required to open the house to the public.
On one level, I get the opposition. The house is in a residential area. It's on a dead end street. There isn't a lot of room for cars and traffic.
But that doesn't mean I like it. Or that I agree with it.
This is more than a house – it is a museum of one woman's life work – and it is extremely rare to have objects displayed in the place where they were originally created. Being thus displayed creates an unmatchable energy linking the art to its environment.
This was part of the Hamilton Wood Type & Print Museum's heartbreak when forced to leave its space last year.
If the house could stay intact and be zoned so that it could open as a museum, there would be finite hours of operation and designated parking. This would eliminate a large portion of drive-by traffic because it would remove the mystique. The barbed wire surrounding the premises and the fact it was off-limits was very much a part of the appeal.
If suddenly the Mary Nohl house were open to the public, it would become more what it should be: an artistic tribute to the incredible work of a Wisconsin artist and not a Halloween-time attraction.
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Murder, She Wrote 1984 | TV Show Watchlist
Season 8, Episode 11 Danse Diabolique
First Aired: January 5, 1992
A ballerina becomes the third victim of a reputedly cursed ballet in which a dancer died in each of its previous performances. Marisa Berenson. Hale: Adrian Paul. Presser: Daniel Pilon. Bolo: Robert Torti. Carroll: Stephen Nichols. Jessica: Angela Lansbury.
Guest Cast
Mark Costello Mark Costello Sgt. O'Connor
Daniel Pilon Daniel Pilon Geoffreyl Presser
Ernie Lively Ernie Lively Lt. Martin Kinicki
Robert Torti Robert Torti Damien Bolo
Marisa Berenson Marisa Berenson Claudia Cameron
Adrian Paul Adrian Paul Edward Hale
Lindy Nisbet Lindy Nisbet Florist Shop Clerk
Nancy Valen Nancy Valen Lily Roland
Stephen Nichols Barry Carroll
Joel Weiss Joel Weiss Delivery Boy
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- Premiered: September 30, 1984
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- Premise: A feisty widow solves murders when she's not writing about them in her home town of Cabot Cove, Maine, a coastal community with a peculiarly high homicide rate. A Sunday-night staple on CBS, this hugely popular drama was Angela Lansbury's first regular ser… (more)
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Dean of Undergraduate Admissions and Financial Aid Jessica Marinaccio said in a statement Tuesday that the Columbia College and School of Engineering and Applied Science financial aid office will undergo a series of structural changes as a result of the review, which was designed to increase communication between the office and students. In addition to allowing students to work with any financial aid adviser, the office has hired four additional staff members, and office hours will be expanded from six to 40 hours per week.
Marinaccio wouldnt speak on the record about the changes, but she said in the statement that theyre intended to increase the efficiency with which students concerns are addressed.
Paying for college can be a challenging prospect, Marinaccio said in a statement. We want to help students and families more smoothly negotiate this complicated process and feel that these changes will help us do that.
The internal reviewwhich was implemented by former financial aid dean Laurie Schaffler, who left Columbia in Mayconsisted of focus groups, a student survey, and educational groups. It found that students were unhappy with financial aid officers response times to emails and phone calls, wanted more information about their financial aid packages, and would like to know more about the exact role of financial aid officers.
The review also showed that parents often interact with financial aid officers more directly than students do. As a result, students will now have the option of including their parents in communications with the office.
Columbia College Student Council President Karishma Habbu, CC 13, spearheaded the review with Schaffler last semester. Habbu said that the changes address all three of the major student concernstimeliness, communication, and educational outreach.
These changes are greatthey are exactly what we need, she said.
Habbu added that she is thrilled with the quick follow-up by the financial office and its staff.
They went above and beyond, she said.
The results of the review were shared last month with Habbu, Engineering Student Council President Tim Qin, SEAS 13, Columbia College Dean James Valentini, and School of Engineering and Applied Science Interim Dean Don Goldfarb.
The evaluation also showed that students were generally satisfied with their individual interactions with financial aid officers, although few had actually stopped by the office. Parents, for whom data was collected through a survey conducted by the Consortium on Financing Higher Education, were also generally pleased with the services provided.
Marinaccio was appointed to her current position in August, when the offices of financial aid and admissions merged. She has served as dean of admissions since 2004.


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Locating your pelvic floorYour pelvic floor is the diaphragm-like muscle that supports your urethra, vagina and colon. You can locate this by stopping your urine mid-stream by contracting the pelvic floor muscles. That feeling? That's how you find it. How to do the exercises1. Kegel exercise consists of both tightening & relaxing the pelvic muscle. Be sure to relax completely between each muscle tightening.2. Incorporate both quick contractions and long contractions into your exercise regimen.3. Short quick contractions (2 seconds) - Contract/tighten your pelvic muscle quickly and hard,4. and immediately relax it.5. Long contractions (3-10 seconds) - Tighten your pelvic muscle and hold for a count of 3 seconds, then relax the muscle completely for a count of 3 seconds. Over time increase the length of time you tighten and hold the muscle.6. Try to do the exercises in all 3 positions: sitting,standing & lying down. If you experience urine loss in one specific position only, increase the number of exercises for that position.7. Concentrate and tighten only the pelvic floor muscle. • DO NOT tighten leg muscles (thighs), buttocks or abdomen. If you feel your stomach move, then you are also using these muscles. • DO NOT hold your breath. Breathe normally and/or count out loud.Vaginal weights and ben-wa ballsYou can also use vaginal weights (tampon-shaped weights) or balls inserted into the vagina to strengthen the muscles.Benefits:• Increase of blood flow keeps the tissue healthier.• Vaginal wall will get thicker.• More oxygen is pumped and it will keep the woman more lubricated.• Men will be able to sustain an erection for longer periods of time.• The intensity of orgasm will increase.• The prostate gland will remain healthier.Do you think these tips will work for you? Do you have any more to share with us?
Show him, or her, what you've got in bed tonight!
If you've never had a problem with your body and how other people see it, this column is not for you. For the rest, Dorothy Black turns the spotlight on body confidence in the bedroom.
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, Volume 25, Issue 4, pp 271-283
Iliopsoas Bursitis and Tendinitis
- Christopher A. M. JohnstonAffiliated withFaculty of Medicine, Queen's University
- , J. Preston WileyAffiliated withSport Medicine Centre, Faculty of Kinesiology, The University of Calgary
- , David M. LindsayAffiliated withSport Medicine Centre, Faculty of Kinesiology, The University of Calgary
- , David A. WisemanAffiliated withDepartment of Radiology, Foothills Hospital and the Faculty of Medicine, The University of Calgary
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This review examines the diagnosis and management of iliopsoas bursitis and/or tendinitis. It is a relatively uncommon and unrecognised cause of anterior hip pain and anterior snapping hip. In view of its pathology, iliopsoas bursitis might be better referred to as iliopsoas syndrome. It can usually be diagnosed by history and physical examination, though real time ultrasound may be useful in confirming the diagnosis. Magnetic resonance and computerised tomography imaging have limited roles in its diagnosis, but may identify other pathology or surgical lesions. Nonoperative management has not been well established. Surgical management does not guarantee treatment success. There is a need for further research into both diagnostic and treatment options for those patients with iliopsoas bursitis/tendinitis.
- Title
- Iliopsoas Bursitis and Tendinitis
- Journal
Sports Medicine
Volume 25, Issue 4 , pp 271-283
- Cover Date
- 1998-04
- 10.2165/00007256-199825040-00005
- Print ISSN
- 0112-1642
- Online ISSN
- 1179-2035
- Publisher
- Springer International Publishing
- Additional Links
- Topics
- Industry Sectors
- Authors
- Author Affiliations
- 1. Faculty of Medicine, Queen's University, Kingston, Ontario, Canada
- 2. Sport Medicine Centre, Faculty of Kinesiology, The University of Calgary, 2500 University Dr NW, Calgary, Alberta, T2N 1N4, Canada
- 3. Department of Radiology, Foothills Hospital and the Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada


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