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|By Business Wire
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|January 18, 2013 08:02 AM EST
Hitachi Data Systems Corporation (HDS), a wholly owned subsidiary of Hitachi, Ltd. (TSE: 6501), today announced that FORTUNE magazine recognizes HDS as one of the "100 Best Companies to Work For" in 2013. This is the second consecutive year the company has been named on this prestigious annual list. This year HDS ranked No.63, moving up from No. 86 in 2012.
Nancy Long, executive vice president and Chief Human Resources Officer, Hitachi Data Systems, attributes this honor and company success to the hard work and dedication of all HDS employees. "I see HDS employees work together as a family to innovate and win, and we're the best at what we do. We're so proud to have been included for a second consecutive year as a FORTUNE 2013 best company to work for. This prestigious and highly-coveted distinction speaks volumes about HDS, our employees and the motivation that continues to drive us to be the best place to work, win and lead change in the industry."
HDS has also again been named by Chief Executive magazine to its annual "40 Best Companies for Leaders" list in 2013. This year HDS ranks No. 7 under the continued leadership and innovation of CEO Jack Domme, moving up from the No. 16 position in the 2012 and No. 36 in 2011.
Today's announcement adds to the list of accolades received by Hitachi Data Systems consistently over the years. The company was recognized as one of the World's Most Ethical Companies by the Ethisphere Institute in 2011and 2012, and was named to the top 10 best places to work in the San Francisco Bay Area for the past four consecutive years, as well as a best place to work in Poland in 2011 and 2012.
About FORTUNE's 100 Best Companies to Work For
To pick the 100 Best Companies to Work For, FORTUNE partners with the Great Place to Work Institute to conduct the most extensive employee survey in corporate America. Two hundred fifty nine firms participated in this year's survey. More than 277,000 employees at those companies responded to a survey created by the institute, a global research and consulting firm operating in 45 countries around the world. Two-thirds of a company's score is based on the results of the institute's Trust Index survey, which is sent to a random sample of employees from each company. The survey asks questions related to their attitudes about management's credibility, job satisfaction, and camaraderie. The other third is based on responses to the institute's Culture Audit, which includes detailed questions about pay and benefit programs and a series of open-ended questions about hiring practices, methods of internal communication, training, recognition programs, and diversity efforts. The list and related stories will appear in the February 4, 2013 print edition of FORTUNE Magazine, and are available now at www.fortune.com/bestcompanies.
About Chief Executive Magazine's 40 Best Companies for Leaders
The annual ranking of the Top Companies for Leadership is based on a survey of leading organizations globally, which is conducted in partnership with Chally Group Worldwide a sales and leadership talent management firm. Companies were scored on five key criteria; having a formal leadership process in place, the commitment level of the CEO to the leadership development program, as measured by the percent of personal time spent in these activities, the depth of the leadership funnel as measured by the percentage of senior management positions filled by internal candidates, as well as the percentage of middle-management positions filled by internal candidates, number of other companies that report recruiting from the company being evaluated and shareholder value performance metric based on 10-year growth or decline in market capitalization. The list is available now at http://chiefexecutive.net/40-best-companies-for-leaders-list.
Web Resources
- Read what Nancy Long and Asim Zaheer, senior vice president, Worldwide Marketing, Hitachi Data Systems, have to say about the awards.
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About Hitachi Data Systems
Hitachi Data Systems provides best-in-class information technologies, services and solutions that deliver compelling customer ROI, unmatched return on assets (ROA) and demonstrable business impact. With a vision that IT must be virtualized, automated, cloud-ready and sustainable, Hitachi Data Systems offers solutions that improve IT costs and agility. With approximately 5,900 employees worldwide, Hitachi Data Systems does business in more than 100 countries and regions. Hitachi Data Systems products, services and solutions are trusted by the world's leading enterprises, including more than 70 percent of the Fortune 100 and more than 80 percent of the Fortune Global 100. Hitachi Data Systems believes that data drives our world – and information is the new currency. To learn more, visit: http://www.hds.com.
About Hitachi, Ltd.
Hitachi, Ltd. (TSE: 6501), headquartered in Tokyo, Japan, is a leading global electronics company with approximately 320,000 employees worldwide. Fiscal 2011 (ended March 31, 2012) consolidated revenues totaled 9,665 billion yen ($117.8 billion). Hitachi is focusing more than ever on the Social Innovation Business, which includes information and telecommunication systems, power systems, industrial, transportation and urban development systems, as well as the sophisticated materials and key devices that support them. For more information on Hitachi, please visit the company's website at http://www.hitachi.com.
© Hitachi Data Systems Corporation 2012. All rights reserved. HITACHI is a trademark or registered trademark of Hitachi, Ltd. Innovate With Information is a trademark or registered trademark of Hitachi Data Systems Corporation. All other trademarks, service marks, and company names are properties of their respective owners.
SYS-CON Events announced today that Micron Technology, Inc., a global leader in advanced semiconductor systems, will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Micron's broad portfolio of high-performance memory technologies – including DRAM, NAND and NOR Flash – is the basis for solid state drives, modules, multichip packages and other system solutions. Backed by more than 35 years of technology leadership, Micron's memory solutions enable the world's most innovative computing, consumer,...
Sep. 2, 2015 05:30 PM EDT Reads: 257
SYS-CON Events announced today the Containers & Microservices Bootcamp, being held November 3-4, 2015, in conjunction with 17th Cloud Expo, @ThingsExpo, and @DevOpsSummit at the Santa Clara Convention Center in Santa Clara, CA. This is your chance to get started with the latest technology in the industry. Combined with real-world scenarios and use cases, the Containers and Microservices Bootcamp, led by Janakiram MSV, a Microsoft Regional Director, will include presentations as well as hands-on demos and comprehensive walkthroughs.
Sep. 2, 2015 04:45 PM EDT Reads: 387
SYS-CON Events announced today that Pythian, a global IT services company specializing in helping companies leverage disruptive technologies to optimize revenue-generating systems, has been named "Bronze Sponsor" of SYS-CON's 17th Cloud Expo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Founded in 1997, Pythian is a global IT services company that helps companies compete by adopting disruptive technologies such as cloud, Big Data, advanced analytics, and DevOps to advance innovation and increase agility. Specializing in designing, imple...
Sep. 2, 2015 04:15 PM EDT Reads: 347
In his session at @ThingsExpo, Lee Williams, a producer of the first smartphones and tablets, will talk about how he is now applying his experience in mobile technology to the design and development of the next generation of Environmental and Sustainability Services at ETwater. He will explain how M2M controllers work through wirelessly connected remote controls; and specifically delve into a retrofit option that reverse-engineers control codes of existing conventional controller systems so they don't have to be replaced and are instantly converted to become smart, connected devices.
Sep. 2, 2015 04:15 PM EDT Reads: 207
Akana has announced the availability of the new Akana Healthcare Solution. The API-driven solution helps healthcare organizations accelerate their transition to being secure, digitally interoperable businesses. It leverages the Health Level Seven International Fast Healthcare Interoperability Resources (HL7 FHIR) standard to enable broader business use of medical data. Akana developed the Healthcare Solution in response to healthcare businesses that want to increase electronic, multi-device access to health records while reducing operating costs and complying with government regulations.
Sep. 2, 2015 04:00 PM EDT Reads: 276
17th Cloud Expo, taking place Nov 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy. Meanwhile, 94% of enterprises are using some form of XaaS – software, platform, and infrastructure as a service.
Sep. 2, 2015 04:00 PM EDT Reads: 1,577
With the Apple Watch making its way onto wrists all over the world, it's only a matter of time before it becomes a staple in the workplace. In fact, Forrester reported that 68 percent of technology and business decision-makers characterize wearables as a top priority for 2015. Recognizing their business value early on, FinancialForce.com was the first to bring ERP to wearables, helping streamline communication across front and back office functions. In his session at @ThingsExpo, Kevin Roberts, GM of Platform at FinancialForce.com, will discuss the value of business applications on wearable ...
Sep. 2, 2015 04:00 PM EDT
The 3rd International WebRTC Summit, to be held Nov. 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA, announces that its Call for Papers is now open. Topics include all aspects of improving IT delivery by eliminating waste through automated business models leveraging cloud technologies. WebRTC Summit is co-located with 15th International Cloud Expo, 6th International Big Data Expo, 3rd International DevOps Summit and 2nd Internet of @ThingsExpo. WebRTC (Web-based Real-Time Communication) is an open source project supported by Google, Mozilla and Opera that aims to enable bro...
Sep. 2, 2015 03:45 PM EDT Reads: 1,559
The 17th International Cloud Expo has announced that its Call for Papers is open. 17th International Cloud Expo, to be held November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, APM, APIs, Microservices, Security, Big Data, Internet of Things, DevOps and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportunity. Submit your speaking proposal today!
Sep. 2, 2015 03:30 PM EDT Reads: 1,640
SYS-CON Events announced today that the "Second Containers & Microservices Expo" will take place November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Containers and microservices have become topics of intense interest throughout the cloud developer and enterprise IT communities.
Sep. 2, 2015 03:15 PM EDT Reads: 623
WebRTC services have already permeated corporate communications in the form of videoconferencing solutions. However, WebRTC has the potential of going beyond and catalyzing a new class of services providing more than calls with capabilities such as mass-scale real-time media broadcasting, enriched and augmented video, person-to-machine and machine-to-machine communications. In his session at @ThingsExpo, Luis Lopez, CEO of Kurento, will introduce the technologies required for implementing these ideas and some early experiments performed in the Kurento open source software community in areas ...
Sep. 2, 2015 02:15 PM EDT
Consumer IoT applications provide data about the user that just doesn't exist in traditional PC or mobile web applications. This rich data, or "context," enables the highly personalized consumer experiences that characterize many consumer IoT apps. This same data is also providing brands with unprecedented insight into how their connected products are being used, while, at the same time, powering highly targeted engagement and marketing opportunities. In his session at @ThingsExpo, Nathan Treloar, President and COO of Bebaio, will explore examples of brands transforming their businesses by t...
Sep. 2, 2015 02:00 PM EDT Reads: 264
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
Sep. 2, 2015 01:30 PM EDT Reads: 939
While many app developers are comfortable building apps for the smartphone, there is a whole new world out there. In his session at @ThingsExpo, Narayan Sainaney, Co-founder and CTO of Mojio, will discuss how the business case for connected car apps is growing and, with open platform companies having already done the heavy lifting, there really is no barrier to entry.
Sep. 2, 2015 12:45 PM EDT Reads: 194
Too often with compelling new technologies market participants become overly enamored with that attractiveness of the technology and neglect underlying business drivers. This tendency, what some call the "newest shiny object syndrome," is understandable given that virtually all of us are heavily engaged in technology. But it is also mistaken. Without concrete business cases driving its deployment, IoT, like many other technologies before it, will fade into obscurity.
Sep. 2, 2015 12:15 PM EDT Reads: 414
With major technology companies and startups seriously embracing IoT strategies, now is the perfect time to attend @ThingsExpo in Silicon Valley. Learn what is going on, contribute to the discussions, and ensure that your enterprise is as "IoT-Ready" as it can be! Internet of @ThingsExpo, taking place Nov 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 17th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal an...
Sep. 2, 2015 11:30 AM EDT Reads: 1,997
With the proliferation of connected devices underpinning new Internet of Things systems, Brandon Schulz, Director of Luxoft IoT – Retail, will be looking at the transformation of the retail customer experience in brick and mortar stores in his session at @ThingsExpo. Questions he will address include: Will beacons drop to the wayside like QR codes, or be a proximity-based profit driver? How will the customer experience change in stores of all types when everything can be instrumented and analyzed? As an area of investment, how might a retail company move towards an innovation methodolo...
Sep. 2, 2015 11:15 AM EDT Reads: 494
As more intelligent IoT applications shift into gear, they're merging into the ever-increasing traffic flow of the Internet. It won't be long before we experience bottlenecks, as IoT traffic peaks during rush hours. Organizations that are unprepared will find themselves by the side of the road unable to cross back into the fast lane. As billions of new devices begin to communicate and exchange data – will your infrastructure be scalable enough to handle this new interconnected world?
Sep. 2, 2015 11:15 AM EDT Reads: 185
The Internet of Things is in the early stages of mainstream deployment but it promises to unlock value and rapidly transform how organizations manage, operationalize, and monetize their assets. IoT is a complex structure of hardware, sensors, applications, analytics and devices that need to be able to communicate geographically and across all functions. Once the data is collected from numerous endpoints, the challenge then becomes converting it into actionable insight.
Sep. 2, 2015 09:00 AM EDT
Contrary to mainstream media attention, the multiple possibilities of how consumer IoT will transform our everyday lives aren't the only angle of this headline-gaining trend. There's a huge opportunity for "industrial IoT" and "Smart Cities" to impact the world in the same capacity – especially during critical situations. For example, a community water dam that needs to release water can leverage embedded critical communications logic to alert the appropriate individuals, on the right device, as soon as they are needed to take action.
Sep. 2, 2015 08:45 AM EDT


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The organization also announced the creation of the Attendee Endowment Funding program.
The Snowfighters Institute is pleased to announce the launch of its new and improved website: www.snowfightersinstitute.com.
The new website contains information pertinent to those who are interested in attending upcoming events at the Institute or those offered by the Institute. Visitors can easily access information about Snowfighters Institute and its facilitators, along with a calendar outlining scheduled events, information on the events themselves, and sign up for our e-newsletters.
Along with the new website, the Institute is proud to announce an endowment program that will be launched in conjunction with the website.
"The Institute endeavors to advance the professionalism of a snow contractor's service offering so as to become better at delivering risk management services through effective and efficient use of snow and ice management techniques" explains John Allin.
"The Attendee Endowment Funding program is designed to allow manufacturers and/or suppliers the opportunity to provide snow contractors the chance to attend Snowfighters Institute events," says Allin.
Contractors will be able to apply for these endowments online.
Jim Huston's summer brainstorming session focused on the ups and downs of buying companies and also included an inside look at one of L&L's Top 100 companies.
Grass prices have stabilized and should stay steady.
The irrigation company has six locations in Alabama and Florida.
Mike Harris and Craig Geddis will both take on the role of branch manager.
Ibn Furaha-Ali will be in charge of the King of Prussia Landscape Maintenance branch.

subset: commoncrawl


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Former Tiger Great Terrell McIntyre to Have Jersey Retired by Italian Team Wednesday
Former Clemson guard Terrell McIntyre will have his No. 5 jersey retired by Montepaschi Siena, the Italian team he took to four consecutive A Series championships from 2007-10. McIntyre led Siena to a combined record of 116-10 in four seasons with the club. He was named the Finals MVP each of his last three seasons in Italy. In 2006-07, his […]Read more


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1. Nanotechnologyis the science that deals with the processes that occur at molecular level and of nanolength scale size. there are three step in the world of measurements the first step is the meter, the second step is micron (world of cells) and the last step is nanometer (smaller than the cell). 'Pharmaceutical nanotechnology'embraces applications of nanoscience to pharmacy as nanomaterials, and as devices like drug delivery, diagnostic, imaging and biosensor. Uses of Nanotechnology: 1-Diagnosis and treatment of cancer According to the US National Cancer Institute (OTIR, 2006) "Nanotechnology will change the very foundations of cancer diagnosis, treatment, and prevention". We have already seen how nanotechnology, an extremely wide and versatile field, can affect many of its composing disciplines in amazingly innovative and unpredictable ways. Q- what is cancer ? Cancer is a disease caused by normal cells changing them so that they grow in an uncontrolled way.
The uncontrolled growth can cause problems in one or more of the following ways: -spreading into normal tissues nearby. -causing pressure on other body structure. -spreading to other parts of the body through the lymphatic system or blood stream. The word cancerwas first applied to the disease by Hippocrates (460–370 B.C.), the Greek philosopher, who used the words carcinosand carcinomato refer to non-ulcer forming and ulcer forming tumors. The words refer to a crab, probably due to the external appearance of cancerous tumors, which have branch-like projections that resemble the claws of a crab. Understanding Cancer Cancer begins in cells, the building blocks that form tissues. Tissues make up the organs of the body. Normally, cells grow and divide to form new cells as the body needs them. When cells grow old, they die, and new cells take their place. Sometimes, this orderly process goes wrong. New cells form when the body does not need them, and old cells do not die when they should. These extra cells can form a mass of tissue called a growth or tumor.
Tumors can be benign or malignant: Benign tumors are not cancer: Benign tumors are rarely life-threatening. Generally, benign tumors can be removed, and they usually do not grow back. Cells from benign tumors do not invade the tissues around them. Cells from benign tumors do not spread to other parts of the body. Malignant tumors are cancer: Malignant tumors are generally more serious than benign tumors. They may be life-threatening. Malignant tumors often can be removed, but sometimes they grow back. Cells from malignant tumors can invade and damage nearby tissues and organs. Cells from malignant tumors can spread (metastasize) to other parts of the body. Cancer cells spread by breaking away from the original (primary) tumor and entering the bloodstream or lymphatic system. The cells can invade other organs, forming new tumors that damage these organs. The spread of cancer is called metastasis. Understanding Cancer Cancer begins in cells, the building blocks that form tissues. Tissues make up the organs of the body.
Normally, cells grow and divide to form new cells as the body needs them. When cells grow old, they die, and new cells take their place. Sometimes, this orderly process goes wrong. New cells form when the body does not need them, and old cells do not die when they should. These extra cells can form a mass of tissue called a growth ortumor. Tumors can be benign or malignant: Benign tumors are not cancer: Benign tumors are rarely life-threatening. Generally, benign tumors can be removed, and they usually do not grow back. Cells from benign tumors do not invade the tissues around them. Cells from benign tumors do not spread to other parts of the body. Malignant tumors are cancer: Malignant tumors are generally more serious than benign tumors. They may be life-threatening.
Malignant tumors often can be removed, but sometimes they grow back. Cells from malignant tumors can invade and damage nearby tissues and organs. Cells from malignant tumors can spread (metastasize) to other parts of the body. Cancer cells spread by breaking away from the original (primary) tumor and entering the bloodstream or lymphatic system. The cells can invade other organs, forming new tumors that damage these organs. The spread of cancer is called metastasis. A schematic illustration showing how nanoparticles or other cancer drugs might be used to treat cancer.
Cancer The small size of nanoparticles endows them with properties that can be very useful in oncology, particularly in imaging. Quantum dots (nanoparticles with quantum confinement properties, such as size- tunable light emission), when used in conjunction with MRI (magnetic resonance imaging), can produce exceptional images of tumor sites. These nanoparticles are much brighter than organic dyes and only need one light source for excitation. This means that the use of fluorescent quantum dots could produce a higher contrast image and at a lower cost than today's organic dyes used as contrast media. The
downside, however, is that quantum dots are usually made of quite toxic elements. Another nanoproperty, high surface area to volume ratio, allows many functional groups to be attached to a nanoparticle, which can seek out and bind to certain tumor cells. Additionally, the small size of nanoparticles (10 to 100 nanometers), allows them to preferentially accumulate at tumor sites (because tumors lack an effective lymphatic drainage system). A very exciting research question is how to make these imaging nanoparticles do more things for cancer. For instance, is it possible to manufacture multifunctional nanoparticles that would detect, image, and then proceed to treat a tumor? This question is under vigorous investigation; the answer to which could shape the future of cancer treatment> promising new cancer treatment that may one day replace radiation and chemotherapy is edging closer to human trials. Kanzius RF therapy attaches microscopic nanoparticles to cancer cells and then "cooks" tumors inside the body with radio waves that heat only the nanoparticles and the adjacent (cancerous) cells. Sensor test chips containing thousands of nanowires, able to detect proteins and other biomarkers left behind by cancer cells, could enable the detection and
diagnosis of cancer in the early stages from a few drops of a patient's blood. The basic point to use drug delivery is based upon three facts: a) efficient encapsulation of the drugs, b) successful delivery of said drugs to the targeted region of the body, and c) successful release of that drug there. Researchers at Rice University under Prof. Jennifer West, have demonstrated the use of 120 nm diameter nanoshells coated with gold to kill cancer tumors in mice. The nanoshells can be targeted to bond to cancerous cells by conjugating antibodies or peptides to the nanoshell surface. By irradiating the area of the tumor with an infrared laser, which passes through flesh without heating it, the gold is heated sufficiently to cause death to the cancer cells.] Nanoparticles of cadmium selenide (quantum dots) glow when exposed to ultraviolet light. When injected, they seep into cancer tumors. The surgeon can see the glowing tumor, and use it as a guide for more accurate tumor removal. In photodynamic therapy, a particle is placed within the body and is illuminated with light from the outside. The light gets absorbed by the particle and if the particle is metal, energy from the light will heat the particle and surrounding tissue. Light may also be used to produce high energy oxygen molecules which will chemically react with and destroy most organic
molecules that are next to them (like tumors). This therapy is appealing for many reasons. It does not leave a "toxic trail" of reactive molecules throughout the body (chemotherapy) because it is directed where only the light is shined and the particles exist. Photodynamic therapy has potential for a noninvasive procedure for dealing with diseases, growth and tumors. Chemotherapy is the delivery of drugs to treat disease, most commonly cancer, and radiation therapy is the use of high energy ionizing radiation to inhibit the division and growth of cells (usually cancer cells). Both of these therapy options are highly effective in treating many types of cancers; however they can also affect the normal healthy cells in the body, inducing unwanted side effects. Most of the side effects from chemotherapy and radiation subside when treatments end, but there are some that can be long-term. Dryness
Mucous membranes and glands, such as salivary glands and tear glands, are sensitive to radiation and some chemotherapy medications. Radiation therapy to the head and neck region can induce xerostomia (dry mouth) and xerophthalmia (dry eyes). Radiation can also affect the sweat glands, causing them to stop working and making temperature regulation difficult. These conditions may be long-term and do affect the patient's overall quality of life. Hair Loss Hair follicles contain rapidly growing and dividing cells making them susceptible to damage from both chemotherapy and radiation therapy. This damage causes hair loss, which is usually temporary. Chemotherapy can cause hair loss over all of your body, but radiation only causes hair loss to the localized area where it was administered. Depending on the medication and the level of radiation, the damage to the hair follicle can be extensive enough to induce permanent hair loss . Secondary Tumors A secondary tumor is the formation of a new and unrelated cancer as a result of the treatment of
another cancer. The secondary cancer usually arises months, or more likely even years after the initial treatment. Both chemotherapy and radiation are known carcinogens, meaning they can cause cancer. The risk of secondary tumors is usually so low that the benefits of the treatment outweigh the risks, but your doctor will continue to monitor your overall health, even after treatments have ended Hearing Loss Chemotherapy medications, especially cis-platin, can cause tinnitus, which is a ringing sensation in your ears. There is no specific treatment for tinnitus, so it can lead to hearing loss. Radiation therapy administered to the brain can cause damage to the inner ear, resulting in hearing loss as well. Infertility The cells of the reproductive system for both men and women are rapidly dividing cells, making them vulnerable to damage from both chemotherapy and radiation therapy. For men, chemotherapy treatments
can cause permanent damage to the testes that produce the sperm as well as the sperm. Radiation to the area of the testes reduces the number and functionality of the present sperm. High doses of radiation can induce long-term effects. In both cases you may want to consult your doctor about freezing some of your sperm to ensure your ability to father children in the future. Chemotherapy can cause permanent damage to the ovaries, which are responsible for producing hormones essential to fertility. Radiation therapy to the pelvis region can cause women to experience signs of menopause, which may be long-term if the radiation dose is high Improved Diagnostics Nanodevices can provide rapid and sensitive detection of cancer-related molecules by enabling scientists to detect molecular changes even when they occur only in a small percentage of cells. This would allow early detection of cancer – a critical step in improving cancer treatment.
Nanotechnology will allow the reduction of screening tools which means that many tests can be run on a single device. This makes cancer screening faster and more cost- efficient. Nanowires Nanowires by nature have incredible properties of selectivity and specificity. Nanowires can be engineered to sense and pick up molecular markers of cancer cells. By laying down nanowires across a microfluidic channel and allowing cells or particles to flow through it. The wires can detect the presence of genes and relay the information via electrical connections to doctors and researchers. This technology can help
pinpoint the changes in the genetics of cancer. Nanowires can be coated with a probe such as an antibody that binds to a target protein. Proteins that bind to the antibody will change the nanowire's electrical conductance and this can be Particles flow through microfluidic channel measured by a detector. 2 Jim Heath, a nanotechnology researcher at California Institute of Technology has designed a nanowire detector. Each nanowire bears a different antibody or oligonucleotide, a short stretch of DNA that can be used to recognize specific RNA sequences. They have begun testing the chip on proteins secreted by cancer cells. 2 Carbon nanotubes are also being used to make DNA biosensors. This uses self-assembled carbon nanotubes and probe DNA oligonucleotides immobilized by covalent binding to the nanotubes. When hybridization between the probe and the target DNA sequence occurs, the change is noted in the voltammetirc peak of an indicator. 3 The DNA biosensors being developed are more efficient and more selective than current detection methods.
Cantilevers Nanoscale cantilevers are built using semiconductor lithographic techniques. 1 These can be coated with molecules (like antibodies) capable of binding to specific molecules that only cancer cells secrete. When the target molecule binds to the antibody on the cantilever, a physical property of the cantilever changes and the change can be detected. Researchers can study the binding real time and the information may also allow quantitative analysis. The nanometer- sized cantilevers are extremely sensitive and can detect single molecules of DNA or protein. Thus providing fast and sensitive detection methods for cancer related molecules.
• Types of Nanoparticles as Drug Delivery • • Systems • Nanoparticles can consist of a number of materials, including polymers, metals, and ceramics. Based on their manufacturing methods and materials used, these particles can adopt diverse shapes and sizes with distinct properties. Many types of nanoparticles are under various stages of development as drug delivery systems, including liposomes and other lipid-based carriers (such as lipid emulsions and lipid-drug complexes), polymer-drug conjugates, polymer microspheres, micelles, and various ligand-targeted products (such as immunoconjugates0 • Liposomes and Other Lipid-based Nanoparticles • Liposomes are self-assembling, spherical, closed colloidal structures composed of • lipid bilayers that surround a central aqueous space. Liposomes are the most studied formulation of nanoparticle for drug delivery (). Several types of anticancer drugs have been developed as lipid-based systems by using a variety of preparation methods. Liposomal formulations have shown an ability to
improve the pharmacokinetics and pharmacodynamics of associated drugs.1 To date, liposome-based formulations of several anticancer agents (Stealth liposomal doxorubicin [Doxil], liposomal doxorubicin [Myocet], and liposomal daunorubicin [DaunoXome]) have been approved for the treatment of metastatic breast cancer and Kaposi's sarcoma.2 • First generation liposomes have an unmodified phospholipid surface that can attract plasma proteins, which in turn trigger recognition and uptake of the liposomes by the mononuclear phagocytic system (MPS), which is synonymous with the reticuloendothelial system,1 resulting in their rapid clearance from the circulation. This property impedes the distribution of liposomes and their associated drug to solid tumors or other non-MPS sites of drug action. Second generation liposomal drugs are being developed in an effort to evade MPS recognition and subsequent clearance. Surface-modified liposomes (Stealth) have hydrophilic carbohydrates or polymers, which usually are lipid derivatives of polyethylene glycol (PEG) grafted to the liposome surfaceWhile this surface modification has solved the problem of fast clearance from the circulation, yielding liposomes with a significantly increased half-life in the blood, the challenge remains to attain
preferential accumulation of liposomes in tumor tissues. One strategy to achieve tumor-specific targeting is to conjugate a targeting moiety on the outer surface of the lipid bilayer of the liposome that selectively delivers drug to the desired site of action. For example, an immunoliposome has antibodies or antibody fragments conjugated on its outer surface, usually at the terminus of PEG. Several studies have documented improved therapeutic efficacy of immunoliposomes targeted to internalizing antigens or receptors compared with that of nontargeted liposomes. An in vitro study of a liposome formulation of doxorubicin (DOX) targeted to the internalizing antigen CD44 on B16F10 melanoma cells showed enhanced intracellular drug uptake from the targeted liposomes when compared with the free form of DOX. The enhanced uptake was correlated with enhanced cell killing efficacy. A liposomal formulation of cisplatin that lacked efficacy demonstrated encouraging therapeutic results when delivered in an immunoliposome targeted to an internalizing antigen. Recently, promising results were reported from a Phase I clinical study that evaluated the effect of MCC-465, a PEGylated liposomal formulation containing DOX targeted with an F(ab')2 fragment of a human mAb named GAH, in patients with metastatic stomach cancer
• Targeted Delivery of Therapeutic Nanoparticles • Passive Targeting • Passive targeting takes advantage of the inherent size of nanoparticles and the unique properties of tumor vasculature, such as the enhanced permeability and retention (EPR) effect and the tumor microenvironment.79,80,81–82 This approach can effectively enhance drug bioavailability and efficacy. • EPR Effect. Angiogenesis is crucial to tumor progression. Angiogenic blood vessels in tumor tissues, unlike those in normal tissues, have gaps as large as 600 to 800 nm between adjacent endothelial cells.18,83 This defective vascular architecture coupled with poor lymphatic drainage induces the EPR effect,83,84,85–86 which allows nanoparticles to extravasate through these gaps into extravascular spaces and accumulate inside tumor tissues87 (Figure 1). Dramatic increases in tumor drug accumulation,
usually of 10-fold or greater, can be achieved when a drug is delivered by a nanoparticle rather than as a free drug.88 However, the localization of nanoparticles within the tumor is not homogeneous. The factors that result in high concentrations of nanoparticles in one part of the tumor tissue but not in other parts are not well understood yet.89 In general, the accumulation of nanoparticles in tumors depends on factors including the size, surface characteristics, and circulation half-life of the nanoparticle and the degree of angiogenesis of the tumor. Usually, less nanoparticle accumulation is seen in preangiogenic or necrotic tumors.18 • Tumor Microenvironment. Hyperproliferative cancer cells have profound effects on their surrounding microenvironment. Tumors must adapt to use glycolysis (hypoxic metabolism) to obtain extra energy, resulting in an acidic microenvironment.81 In addition, cancer cells overexpress and release some enzymes that are crucial to tumor migration, invasion, and metastasis, including matrix metalloproteinases (MMPs).82 Tumor-activated prodrug therapy is an example of passive targeting that takes advantage of this characteristic of the tumor-associated microenvironment. A nanoparticle conjugating an albumin-bound form of DOX with an MMP-2–
specific peptide sequence (Gly-Pro-Leu-Gly-Ile-Ala- Gly-Gln) was efficiently and specifically cleaved by MMP-2.90 When certain pH-sensitive molecules are incorporated into liposomes, drugs can be specifically released from the complexes by a change in pH.91 The pH-sensitive liposomes are stable at physiologic conditions (pH 7.2), but degraded in tumor- associated acidic areas. Likewise, thermolabile liposomes are expected to be activated by the local hyperthermic microenvironment.92 • Active Targeting • The polymeric nanoparticles that have been tested clinically so far have mostly lacked a targeting moiety and instead rely mainly on the EPR effect of tumors, the tumor microenvironment, and tumor angiogenesis to promote some tumor-selective delivery of nanoparticles to tumor tissues. However, these drug delivery systems using a binary structure conjugate inevitably have intrinsic limitations to the degree of targeting specificity they can achieve. In the case of the EPR effect, while poor lymphatic drainage on the one hand helps the extravasated drugs to be enriched in the tumor interstitium, on the other hand, it induces drug outflow from the cells as a result of higher osmotic pressure in the interstitium, which eventually leads to drug redistribution in some portions of the cancer tissue.93
• An alternative strategy to overcome these limitations is to conjugate a targeting ligand or an antibody to nanoparticles. By incorporating a targeting molecule that specifically binds an antigen or receptor that is either uniquely expressed or overexpressed on the tumor cell surface, the ligand- targeted approach is expected to selectively deliver drugs to tumor tissues with greater efficiency (Figure 2). Such targeted nanoparticles may constitute the next generation of polymeric nanoparticle drug delivery systems. Indeed, several targeted polymeric nanoparticles are currently undergoing preclinical studies.65,77,94,95–96 One of these, HPMA copolymer-DOX-galactosamine (PK2, FCE28069), has progressed to a clinical trial. In this nanoparticle, galactosamine moieties bind to the asialoglycoprotein receptor on hepatocytes.65,76 In a Phase I/II study, this targeted nanoparticle showed 12- to 50-fold greater accumulation than the free DOX in hepatocellular carcinoma tissue. Antitumor activity was observed in patients with primary hepatocellular carcinoma in this study.65,76 These promising early clinical results suggest the potential of targeted polymeric nanoparticles as anticancer drug delivery systems. Lessons have also been learned from many of the early clinical studies. For example, the failure of HPMA conjugates of paclitaxel and camptothecin in Phase I clinical trials was reported. Such negative
outcomes underline the importance of polymer-drug design • Choice of Target Receptor. Selection of the appropriate receptor or antigen on cancer cells is crucial for the optimal design of targeted nanoparticles. The ideal targets are those that are abundantly and uniquely expressed on tumor cells, but have negligible or low expression on normal cells. The targeted antigen or receptor should also have a high density on the surface of the target tumor cells. Whether the targeted nanoconjugate can be internalized after binding to the target cell is another important criterion in the selection of proper targeting ligands. In the case of an antibody or other ligand that cannot trigger the internalization process, the drug can enter cells through simple diffusion or other transport system after being released from the targeted conjugate at or near the cell surface. However, drug released outside the cell may disperse or redistribute to the surrounding normal tissues rather than exclusively to the cancer cells. In vitro and in vivo comparisons using internalizing or noninternalizing ligands have shown that the intracellular concentration of drug is much higher when the drug is released from nanoparticles in the cytoplasm after internalization.43,98
• Choice of Targeting Ligand. One of the greatest challenges to the design of nanoparticles that can selectively and successfully transport drug to cancerous tissues is the choice of targeting agent(s). This strategy also relies on the ability of the targeting agent or ligand to bind the tumor cell surface in an appropriate manner to trigger receptor-mediated endocytosis. The therapeutic agent will thereby be delivered to the interior of the cancer cell.85 A variety of tumor-targeting ligands, such as antibodies, growth factors, or cytokines, have been used to facilitate the uptake of carriers into target cells.90,92,99,100,101,102,103,104,105,106–107 • Ligands targeting cell-surface receptors can be natural materials like folate and growth factors, which have the advantages of lower molecular weight and lower immunogenicity than antibodies. However, some ligands, such as folate that is supplied by food, show naturally high concentrations in the human body and may compete with the nanoparticle- conjugated ligand for binding to the receptor, effectively reducing the intracellular concentration of delivered drug. Recent advances in molecular biology and genetic engineering allow modified antibodies to be used as targeting moieties in an active-targeting approach. MAbs or antibody fragments (such as antigen-binding fragments or single-chain variable fragments) are the most frequently used ligands for
targeted therapies. Whole mAbs have 2 binding domains showing high binding avidity. The Fc domain of the mAb can induce complement-mediated cytotoxicity and antibody-dependent, cell-mediated cytotoxicity, leading to additional cell-killing effect. On the other hand, the Fc domain also initiates an immune response and can be rapidly eliminated in the circulation, resulting in decreased accumulation of targeted nanoparticles into cancer cells.13 Compared with whole mAbs, the use of antibody fragments as a targeting moiety can reduce immunogenicity and improve the pharmacokinetic profiles of nanoparticles.1 For example, liposomes coupled with mAb fragments instead of whole antibodies showed decreased clearance rates and increased circulation half-lives, allowing the liposomes sufficient time to be distributed and bind to the targeted cells.1,39 This strategy improved the therapeutic efficacy of immunoliposomal DOX targeted against CD19 on human B lymphoma cells in animal models
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Updated photo of Daniel Skelton at Nuuanu Safeway
On Thursday, another doctor took the stand in the Jill Hansen trial, and at one point during his testimony, Hansen disagreed with him and let the courtroom know her thoughts.
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Keeper Fernando Henrique gives away a penalty, but then wins one at the other end
- February 15, 2009
- Comments0
Week in, week out, we bring you stories highlighting violence at football matches. And every-so-often we are also able to bring footage of a goalkeeper who managed to score or set up goals. Happily, one match last week in Brazil had it all.
Fluminense keeper Fernando Henrique took centre stage during last week's Carioca 1 match, with the shot-stopper conceding a penalty after dishing out a violent punch in his box, only for the keeper to redeem himself by winning a last minute penalty to earn his side a last-gasp win.
The match started on a bright note for Fluminense as Hamburg loanee Thiago Neves scored a superb free-kick to give his side the lead at halftime.
Heading into the final 10 minutes Flu had managed to hold onto their lead, but then everything appeared to crumble when Fernando Henrique had a moment of madness when he slogged an opponent in his crown jewels. How Henrique was not sent off for his violent punch remains a mystery, but his side were punished as Eberson levelled from the spot.
Amazingly though, in the final minute of the match Henrique then managed to repay his side when he won a stonewall penalty of his own. Flu won a late corner and the keeper came up from the back to try and mix it up in the box. The ball ran loose to Henrique on the edge of the box and the he motioned to keep the attack alive with a header. But as Henrique jumped he was kicked in the stomach by Americano's number 6 and the ref wasted no-time in blowing his whistle. Dario Conca stepped up and scored the injury time winner.
Fernando Henrique's amazing match highlights can be seen here.
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The Roast of Erik Terrell
in Comedy
Listen in as some of his very closest friends hit the line with all of their embarrassing stories and weird habits! Happy Birthday Erik Terrell !!
Assistance to the Incarcerated Mentally Ill (AIMI) Aug. 19, 2015, Terrell Scott
Assistance to the Incarcerated Mentally Ill, Aug. 19, 2015 - Terrell Scott update. Holly Alston will update us on her son, Terrell Scott. He has been imprisoned in Pennsylvania for six years without a trial. He has health concerns now. Call (818)572.2947 to help his mother to know that we care about Terrell.
Rick Fairless of Strokers Dallas
in Automotive
Host Courtney Lambert talks with her friend Rick Fairless - the owner and mastermind behind the Strokers Dallas empire. Rick tells listeners about his compound in Dallas that features a custom bike shop, and tattoo shop and a bar & grill! Saturdays at Strokers get pretty crazy with over 2,000 motorcyclists hanging out every week! Rick gives some advice on how to stay successful in the dog eat dog custom motorcycle industry and tells listeners about a new line of custom parts he recently unveiled for Victory Motorcycles. Later, Dave joins Courtney to talk about the Ride to the 75th - a motorcycle ride he is leading from California to South Dakota for the 75th Anniversay of the Sturgis Motorcycle Rally.
Monday Morning Quarterback Dallas Cowboy Fans Corner
in Sports
Monday Morning Quartback Is a Designed show For Dallas Cowboys Fans around The Globe Your Host and Long Time Dallas Cowboys Fan Joseph Gibson expresses his opinions about this years Dallas Cowboy Team and invites all Dallas Cowboys Fans to join in and discuss and comment on The Dallas Cowboys and predictions for 2015? Live On The Air at blogtalkradio.com/josephgibson all callers please dail 657-383-0616 and press 1 if you have something to say or ask! Nobody is censored or edited! This is a open platform.
2015 NFL SuperFan Series: the Dallas Cowboys
in Sports
With the NFL preseason and regular season on deck, it is time to kick off the NFL "SuperFan" series 2015-style! Tonight I will preview the Dallas Cowboys' (whose hatred I am not shy about) upcoming season with Cowboys' fan Jeremy Winters.
Topics to be covered include:
What went wrong with the 2014 Cowboys?
Thoughts on the Cowboys' draft?
Who is going to pick up the slack for DeMarco Murray?
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Independent Everything: LIVE with Dallas, TX Hip-Hop Artist ~ KINGWEEZY
in Music
Making the transition from most "Slept On" to The New Face of Dallas Hip-Hop, has KINGWEEZY fans boiling with excitement and anticipating his NEXT Gigantic Leap and Career Shifting move.
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TWO YEARS AGO Kingweezy had inspirations to follow his dreams of becoming the piece of the puzzle the music game had been missing ever since the killings of Tupac Shakur and Notorious B.I.G. Now after just one Mixtape, several rapid fire (Song Covers), and a shocking back to back Single release, including the levitating ?#KANYEWEST? Diss/ Micheal Jackson tribute entitled "MIKEJACK"... KINGWEEZY has not only the Dallas,Tx music seen in awww, but is even getting the attention of successful Underground Rap artist such as (Houston Tx) CHALIE Boy, (Dallas ,Tx) Mr. Diabolical, Mr. Lucci, and most recently Dorrough Music, in which Kingweezy had the prestigious opportunity to open up for at the Dallas Night Club Soleil. Needless to say headlining his own events and bringing in a crowd has been the least of the New Artist concerns.. As he became a true pioneer in Dallas Tx. becoming the first artist ever to perform at the Top 40 Nightclub, (none the less) throw a Single Release Party at the infamous Club Thrive late last yr.. Setting records for attendance.
Life Lessons from Law School
in Comedy
Law school graduate, Sydnee Mack, gives Life Lessons from Law School to kick off The Erik Terrell Show's Back to School Series
Rose Dallas Prays | A Week of Prayer & Praise in Review
in Prayer
Join me Rose Dallas as we celebrate our first 7 Days
here on Blog Talk Radio with Rose Dallas Prays.
We will read a Psalm of David, Psalm 19 as we learn more
about the LORD's awesome Creation.
Explore Proverbs 3:1-6 with a Focus on Proverbs 5 & 6 where,
we are admonished to:
"Trust in the LORD with all Our Hearts
Lean Not on Our Own Understanding.
In All Thy Ways Acknowledgge Him and He Shall Direct Our Paths."
It's amazing what the Good LORD can and will do through us
when we Surrender our All to Him.
As we look back together over the past week, we will see the
Love of Jesus and the Love of the Father that they both have
for us. We'll discover how we can call upon the Name of the LORD and
How we should come into His Presence with Thanksgiving and
Praise as He loves our Worship!
Knowing we serve a Great and Mighty God we can place our Trust
and our confidence fully in Him because He cares for us.
My Prayer Beloved is that you know the Magnitude of the LORD's
Precious Love for You and Your Family each and every day. And
no matter what the Circumstances may look like in the Physical,
CHOOSE to BELIEVE Jehovah God is Always at Work Doing
Something NEW on your Behalf...Do You Not Perceive It?
in Sports
WELCOME TO THE SATURDAY AFTERNOON SPECULATION SPORTS PODCAST...45 MINS OF SPORTS........FANTASY SPORTS TALK...HELL NO...BASEBALL IS HEATING UP...THE EAST WILL BE FUN 2 WATCH...IN THE AMERICAN..CAN THE CUBS KEEP IT GOING..we shall see...A LITTLE BASEBALL TALK..OF COURSE..NASCAR TALK...THE KILLER?..AND OF COURSE...NFL TALK...BIG NAMES GOING DOWN..OUT 4 THE SEASON...THE VIKINGS O.L...TROUBLE..ERR...AND DALLAS COWBOYS TALK..PRE-SEASON TALK..LIVE ON TALKSHOE...AND SPREAKER..TWEET AND FACEBOOK THE SHOW...rugburn might in the treehouse...COMM AND MUSIC FREE PODCASTING..IT'S JUST SPORTS PEOPLE..and away we go people..feel free 2 call the show ..SPORTS TALK BABY...CALLING TP...FROM THE CHEFS...AND THE STEELERS...the dog killers is back..SOME PEOPLE JUST DON'T GET IT
NFC East - NFL Preview; Does the division title still go through Dallas?
in Sports
The Philadelphia Eagles finished 10-6, in 2014. Leaving them on the outside looking in, when the playoffs started. Chip Kelly made and interesting move, trading away LeSean McCoy. In return, the Eagles received Kiko Alonso. He missed all of the 2014 season, with a torn ACL. The Eagles also released Trent Cole and Cary Williams, in a salary cap move. Then they signed free agent running back DeMarco Murray. At quarterback, the Eagles devised a trade for often injured Sam Bradford. Nick Foles, who is recovering from a broken collarbone, head to St. Louis. Many moves in the off-season, equals many questions for the Eagles.
The Dallas Cowboys lost running back free agent DeMarco Murray, in free agency. However, they have one of the best offensive lines. The signed Oakland Raider free agent Darren McFadden, who has had his share of injuries. In the preseason, he has already been battling a hamstring injury. The passing combination of Tony Romo to Dez Bryant, will remain intact. However, the question is how much did the running game help Romo last year.
Washington is trying to figure out the quarterback situation. All indications are that Robert Griffen III will get another shot. He has started both pre-season games. On the other side, they need to stop people. As a unit, they allowed 27.4 points per game, in 2014. This ranked 29th, in the NFL. Jay Gruden needs to find some answers, on both sides of the ball.
Eli Manning has not lead the New York Giants to the playoffs, in three years. However, he wants to be the highest paid quarterback. Is that a distraction needed before the season? The Giants were 13th in scoring, but had some inconsistent play defensively. No matter what contract Manning has, they need to find people to protect him. It could be another long year in New York.
in Sports
WELCOME TO THE ONE AND ONLY NFL PODCAST ON THE NET..LOL...MY NAME IS JEFF FROM SPECULATION SPORTS...LET'S TALK NFL PRE-SEASON..SHOULD WE CARE..NOT REALLY...but i guess we can..WHO LOOKS GOOD..WHO SUCKS..the food stealer is town tonight..AT THE BANK..bitch please...DALLAS COWBOYS TALK...super bowl 50 talk..SURE..i guess..TRY 2 TALK ALL 32 TEAMS TODAY...45 mins...LIVE ON TALKSHOE..and spreaker..tweet and facebook the show sports fans...ANY NEWS IN THE NFL..let's talk about...fantasy football talk..GOD NO KIDS..who cares..DON'T LIVE WITH MY MOM...bitch please..and away we go NFL SPORTS FANS
in Sports
WELCOME TO THE ONE AND ONLY NFL PODCAST ON THE NET..LOL...MY NAME IS JEFF FROM SPECULATION SPORTS...LET'S TALK NFL PRE-SEASON..SHOULD WE CARE..NOT REALLY...but i guess we can..WHO LOOKS GOOD..WHO SUCKS..the food stealer is town tonight..AT THE BANK..bitch please...DALLAS COWBOYS TALK...super bowl 50 talk..SURE..i guess..TRY 2 TALK ALL 32 TEAMS TODAY...45 mins...LIVE ON TALKSHOE..and spreaker..tweet and facebook the show sports fans...ANY NEWS IN THE NFL..let's talk about...fantasy football talk..GOD NO KIDS..who cares..DON'T LIVE WITH MY MOM...bitch please..and away we go NFL SPORTS FANS
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January 27, 2013
I am a poet and find writing as a way to explore the spiritual. I am primarily connected with nature and the flow of energy in exercise/sport. I am a bit standoffish with traditional religion and sometimes feel uncomfortable talking of a god. I feel more grounded with nature, movement and sounds.
I am in Mar Vista, a sister community.
Of course! I am more contemplative and I may not feel moved to speak or share. In fact, I am used to practicing mindfulness in a group setting where we may share a bit in the beginning and then we leave without sharing again. I tend to like this end moment of gathering myself and then going back to the world. So, please do not be alarmed/concerned if I do not stay to talk afterwards. I tend to hold on to the silence and peace within.
I am a spiritual seeker.
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|By Randy DeFauw
Article Rating:
|February 2, 2013 12:00 PM EST
By the end of January, it's estimated that 80 percent of those who make New Year's resolutions will have already broken them. The New Year is a time for reflection and introspection, but not necessarily one that leads to action, it seems. The opposite should be true during software companies' annual re-examination of their software development, however. The consequences of not improving development practices can be much more costly than gaining a few more pounds.
Here are six ways to whip software development into shape in 2013:
1. Deliver like Facebook: Facebook dominates its market because it delivers improvements to its site every day. There's no reason you can't deliver small, working improvements to your product almost as quickly. The software tool stack has largely caught up with that velocity, and nothing keeps developers happier than seeing working changes in the product.
So you're not building a SaaS product: don't let that stop you. Product can still rapidly evolve internally without a regulatory process - just adjust the continuous delivery dial back from production servers to formal release handoff. If you're the only one of your competitors with the ability to deliver this quickly, that is quite the competitive advantage.
2. Agile for all levels: You're not really going to be successful with Agile if it's limited to your software teams. DevOps was all about bridging the gap between development and operations, and you'll find greater success by taking Agile cross-functional - imagine your entire company responding as quickly to new requirements as your development team. Agile marketing? It's been done.
3. All aboard the mother ship: Your most valuable assets are your people and your IP - don't operate them in silos. Reuse your IP wherever possible, and make sure your teams can discover and work with each other. If you're buying a startup to acquire the talent, make sure you can incorporate their existing work into your systems in a week - not a year. Make sure they can keep using the tools they know and love (even if you're running something more enterprise-worthy in the background).
4. Take caution with the cloud: The cloud sounds great on paper. Low costs! Infinite scalability! No administration! But in reality the cloud isn't right (yet) for everything you do as a technology company. There are still performance, ownership, and reliability issues to consider. If your employees are asking for a cloud-based solution, figure out why. Do they want Dropbox because they don't have a decent place to store design documents and test plans? Then fix that problem before the team makes a big decision for you.
5. Be a realist: Engineers are practical people. If your current delivery cycle is a year, you won't get it down to a week overnight. Lay out clear goals with a reasonable time frame. If you can go from a year to three months, you're making huge progress and will get buy-in for the next step.
6. Study the America Invents Act: A major change to U.S. patent law is coming into effect in March 2013. Are your IP ducks in a row? Make sure you understand the nuances of first-to-file, prior use and the other big changes. To meet the changing legal framework, be ready to adjust your software processes, from initial design through to shipping to customers. If you're using open source software in your products, make sure you are in compliance with all the licensing and copyright provisions.
As with people, the new year is an ideal time for every organization to take an inventory of what is working well and what is not. The best place to start that process is at the foundation of your software practices - your codebase. A well-organized codebase will not only prevent headaches down the road, but also perfectly position your company for future growth.
Puppet Labs has announced the next major update to its flagship product: Puppet Enterprise 2015.2. This release includes new features providing DevOps teams with clarity, simplicity and additional management capabilities, including an all-new user interface, an interactive graph for visualizing infrastructure code, a new unified agent and broader infrastructure support.
Aug. 29, 2015 03:00 AM EDT Reads: 462
DevOps has traditionally played important roles in development and IT operations, but the practice is quickly becoming core to other business functions such as customer success, business intelligence, and marketing analytics. Modern marketers today are driven by data and rely on many different analytics tools. They need DevOps engineers in general and server log data specifically to do their jobs well. Here's why: Server log files contain the only data that is completely full and accurate in th...
Aug. 29, 2015 12:15 AM EDT Reads: 327
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
Aug. 28, 2015 11:30 PM EDT Reads: 827
SYS-CON Events announced today that G2G3 will exhibit at SYS-CON's @DevOpsSummit Silicon Valley, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Based on a collective appreciation for user experience, design, and technology, G2G3 is uniquely qualified and motivated to redefine how organizations and people engage in an increasingly digital world.
Aug. 28, 2015 02:15 PM EDT Reads: 414
Introducing Containers & Microservices Bootcamp at @CloudExpo Silicon Valley | #Containers #Microservices
SYS-CON Events announced today the Containers & Microservices Bootcamp, being held November 3-4, 2015, in conjunction with 17th Cloud Expo, @ThingsExpo, and @DevOpsSummit at the Santa Clara Convention Center in Santa Clara, CA. This is your chance to get started with the latest technology in the industry. Combined with real-world scenarios and use cases, the Containers and Microservices Bootcamp, led by Janakiram MSV, a Microsoft Regional Director, will include presentations as well as hands-on...
Aug. 28, 2015 12:30 PM EDT Reads: 127
It's been proven time and time again that in tech, diversity drives greater innovation, better team productivity and greater profits and market share. So what can we do in our DevOps teams to embrace diversity and help transform the culture of development and operations into a true "DevOps" team? In her session at DevOps Summit, Stefana Muller, Director, Product Management – Continuous Delivery at CA Technologies, answered that question citing examples, showing how to create opportunities for ...
Aug. 28, 2015 12:00 PM EDT Reads: 446
SYS-CON Events announced today that Pythian, a global IT services company specializing in helping companies leverage disruptive technologies to optimize revenue-generating systems, has been named "Bronze Sponsor" of SYS-CON's 17th Cloud Expo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Founded in 1997, Pythian is a global IT services company that helps companies compete by adopting disruptive technologies such as cloud, Big Data, advance...
Aug. 28, 2015 12:00 PM EDT Reads: 198
What does "big enough" mean? It's sometimes useful to argue by reductio ad absurdum. Hello, world doesn't need to be broken down into smaller services. At the other extreme, building a monolithic enterprise resource planning (ERP) system is just asking for trouble: it's too big, and it needs to be decomposed.
Aug. 28, 2015 11:15 AM EDT Reads: 317
Several years ago, I was a developer in a travel reservation aggregator. Our mission was to pull flight and hotel data from a bunch of cryptic reservation platforms, and provide it to other companies via an API library - for a fee. That was before companies like Expedia standardized such things. We started with simple methods like getFlightLeg() or addPassengerName(), each performing a small, well-understood function. But our customers wanted bigger, more encompassing services that would "do ...
Aug. 28, 2015 11:00 AM EDT Reads: 175
Culture is the most important ingredient of DevOps. The challenge for most organizations is defining and communicating a vision of beneficial DevOps culture for their organizations, and then facilitating the changes needed to achieve that. Often this comes down to an ability to provide true leadership. As a CIO, are your direct reports IT managers or are they IT leaders? The hard truth is that many IT managers have risen through the ranks based on their technical skills, not their leadership ab...
Aug. 28, 2015 10:00 AM EDT Reads: 272
SYS-CON Events announced today that DataClear Inc. will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. The DataClear 'BlackBox' is the only solution that moves your PC, browsing and data out of the United States and away from prying (and spying) eyes. Its solution automatically builds you a clean, on-demand, virus free, new virtual cloud based PC outside of the United States, and wipes it clean...
Aug. 28, 2015 09:45 AM EDT Reads: 338
Whether you like it or not, DevOps is on track for a remarkable alliance with security. The SEC didn't approve the merger. And your boss hasn't heard anything about it. Yet, this unruly triumvirate will soon dominate and deliver DevSecOps faster, cheaper, better, and on an unprecedented scale. In his session at DevOps Summit, Frank Bunger, VP of Customer Success at ScriptRock, will discuss how this cathartic moment will propel the DevOps movement from such stuff as dreams are made on to a prac...
Aug. 28, 2015 09:45 AM EDT Reads: 180
In his session at 17th Cloud Expo, Ernest Mueller, Product Manager at Idera, will explain the best practices and lessons learned for tracking and optimizing costs while delivering a cloud-hosted service. He will describe a DevOps approach where the applications and systems work together to track usage, model costs in a granular fashion, and make smart decisions at runtime to minimize costs. The trickier parts covered include triggering off the right metrics; balancing resilience and redundancy ...
Aug. 28, 2015 09:30 AM EDT Reads: 128
Docker containerization is increasingly being used in production environments. How can these environments best be monitored? Monitoring Docker containers as if they are lightweight virtual machines (i.e., monitoring the host from within the container), with all the common metrics that can be captured from an operating system, is an insufficient approach. Docker containers can't be treated as lightweight virtual machines; they must be treated as what they are: isolated processes running on hosts....
Aug. 28, 2015 09:00 AM EDT
The pricing of tools or licenses for log aggregation can have a significant effect on organizational culture and the collaboration between Dev and Ops teams. Modern tools for log aggregation (of which Logentries is one example) can be hugely enabling for DevOps approaches to building and operating business-critical software systems. However, the pricing of an aggregated logging solution can affect the adoption of modern logging techniques, as well as organizational capabilities and cross-team ...
Aug. 28, 2015 07:30 AM EDT Reads: 351
In today's digital world, change is the one constant. Disruptive innovations like cloud, mobility, social media, and the Internet of Things have reshaped the market and set new standards in customer expectations. To remain competitive, businesses must tap the potential of emerging technologies and markets through the rapid release of new products and services. However, the rigid and siloed structures of traditional IT platforms and processes are slowing them down – resulting in lengthy delivery ...
Aug. 28, 2015 06:45 AM EDT Reads: 539
Skeuomorphism usually means retaining existing design cues in something new that doesn't actually need them. However, the concept of skeuomorphism can be thought of as relating more broadly to applying existing patterns to new technologies that, in fact, cry out for new approaches. In his session at DevOps Summit, Gordon Haff, Senior Cloud Strategy Marketing and Evangelism Manager at Red Hat, discussed why containers should be paired with new architectural practices such as microservices rathe...
Aug. 28, 2015 06:00 AM EDT Reads: 357
Early in my DevOps Journey, I was introduced to a book of great significance circulating within the Web Operations industry titled The Phoenix Project. (You can read our review of Gene's book, if interested.) Written as a novel and loosely based on many of the same principles explored in The Goal, this book has been read and referenced by many who have adopted DevOps into their continuous improvement and software delivery processes around the world. As I began planning my travel schedule last...
Aug. 28, 2015 06:00 AM EDT Reads: 497
Any Ops team trying to support a company in today's cloud-connected world knows that a new way of thinking is required – one just as dramatic than the shift from Ops to DevOps. The diversity of modern operations requires teams to focus their impact on breadth vs. depth. In his session at DevOps Summit, Adam Serediuk, Director of Operations at xMatters, Inc., will discuss the strategic requirements of evolving from Ops to DevOps, and why modern Operations has begun leveraging the "NoOps" approa...
Aug. 28, 2015 03:15 AM EDT Reads: 325
The Microservices architectural pattern promises increased DevOps agility and can help enable continuous delivery of software. This session is for developers who are transforming existing applications to cloud-native applications, or creating new microservices style applications. In his session at DevOps Summit, Jim Bugwadia, CEO of Nirmata, will introduce best practices, patterns, challenges, and solutions for the development and operations of microservices style applications. He will discuss ...
Aug. 27, 2015 02:15 PM EDT Reads: 504


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Stock Market & Financial Investment News
News Breaks
January 6, 2014
First Solar downgraded to Sell from Buy at Goldman
Goldman downgraded First Solar two notches to Sell due to lack of EPS growth as growth shifts to rooftop and away from utility-scale. The firm expects EPS declines and likely cuts to 2015 MW project targets. Price target lowered to $45 from $62.
News For FSLR From The Last 14 Days
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August 25, 2015
SolarCity rises again after Chairman Musk buys shares
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August 24, 2015
President Obama announces new renewable energy commitments
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Goldman says SolarCity attractive after sharp pullback
SolarCity (SCTY) shares are climbing in the down market after Goldman Sachs contended in a note to investors today that the stock is attractive following its recent sharp retreat, The company probably won't be affected by issues that are causing investors to worry about the solar sector, the firm believes. WHAT'S NEW: Noting that SolarCity's stock had tumbled 27% in the last month before today's open, Goldman Sachs analyst Brian Lee wrote that the shares are being dragged down by worries about financing and cost of capital that are affecting the entire solar sector. However, he contended that these issues are having only a "limited" impact on SolarCity. On August 13, the company successfully sold asset-backed securities and it said that more such sales are likely to occur in the near-term, Lee noted. Meanwhile, SolarCity isn't being affected by the cost of capital increases that other solar companies are experiencing, the analyst reported. Before today's open, the stock was near a two year low, even though SolarCity's fundamentals are still "strong," Lee believes. Additionally, the largest U.S. solar trade show, which is expected to begin on September 14, could boost solar stocks, as it has historically been a catalyst for the sector, the analyst stated. SolarCity may provide guidance about the outlook for its Silevo solar panel manufacturing subsidiary in the second half of 2015, and the guidance could boost the stock, Lee believes. The risk/reward ratio of SolarCity's stock is positive, according to the analyst, who has a Conviction List Buy and $85 price target on the shares. OTHERS TO WATCH: Other publicly traded companies in the solar space include Canadian Solar (CSIQ), First Solar (FSLR), JA Solar (JASO), SunEdison (SUNE), SunPower (SPWR), Trina Solar (TSL) and Yingli Green Energy (YGE). PRICE ACTION: In late morning trading, SolarCity advanced 5.3% to $43.18.
August 21, 2015
Solar companies spending $1B in Texas projects, WSJ says
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August 19, 2015
Canadian Solar plummets after Q3 guidance, YieldCo comments
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August 18, 2015
SunEdison raises capital while Trina Solar tops expectations
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The Top 10 In Action Sports
01Living On The Blood and Urine of Dead Sea Turtles: The Shocking Story of A Sailor Stuck in Hell
02No Ropes & No Chickening Out: Deep Water Soloing in Devon
03À la Recherche du Stoke Perdu: How I Rekindled the Fire After Falling Out of Love With Surfing
04Pacific Paradise: A Journey to the Philippines' Final Frontier
05Surfing is for Sellouts: Why Catching Waves with Just Your Body is The Ultimate Ride
06A Journey Into Darkness: We Went Mountain Biking in the Abandoned Mines of Slovenia
07Against All Odds: The Incredible Story of One Surfer's Battle with his Own Government
08Surf. Sit. Repeat. Is a Fake Wave on a Welsh Lake About to Start a Surfing Revolution?
09"Seven Went Up, Only Three Came Down": How The Unsolved Mystery Of The Matterhorn Keeps Our Fascination Alive
10Mad Descents & Lunar Landscapes: Incredible Shots from One of Europe's Best MTB Destinations
Gates Nicolai Mountainbike Team #6 WORLD CUP & 4X WORLD Champs @ Leogang / Austria
A Mountain Biking video by CrossWorx - 76,204 views
The last weekend has been a good one for the team. Swiss vice junior champ Mike Schär could get some more WorldCup race experience including testing the ION 20 Effigear with a CarbonDrive. His team mate Quentin Derbier got his first 4X WorldChamp podium with a great third place. Follow the Team on https://www.facebook.com/pages/Gates-Nicolai-Mountainbike-Team/575257815823217?fref=ts
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City Council members were told Tuesday that the city must spend $412,000 buying a new city park in Ridgedale because of a mistake made by a prior administration in 2003.
Dan Thornton, general services administrator, said at that time the city sold the former Ridgedale Recreation Center to McCallie School for $200,000. He said the appraisal at the time was $240,000.
Mr. Thornton said city officials have been told by the state that, since federal and state funds were used to acquire the Ridgedale Recreation Center property, that a replacement park must be found.
The city will be required to spend $412,000 in today's dollars, he said.
Mr. Thornton said the city is seeking property for the new park within a few miles of the one that was sold.
Councilman Jack Benson noted that the mistake was under "a different mayor and a different parks and recreation director."
He asked who sold the property, and Mr. Thornton said Harvey Webb was real property manager for the city at the time.
Mr. Thornton said city officials are much more careful now to try to flag such restrictions.
September 2, 2015
Kristin Taylor, 23, was arrested on Sunday and charged with aggravated domestic assault after she allegedly threatened her sisters and mother with a broken glass shard and a broom. ... (click for more)
More than a dozen family members gathered in court on Wednesday to hear that Jamichael Harris, a man who is on pretrial house arrest for the June, 2014 murder of Inez Burney, will be allowed ... (click for more)
A woman was injured an ATV accident in the Pocket Wilderness on Wednesday morning. A 911 call was made reporting a woman injured about a half mile up the trail. Fire officials reported ... (click for more)
Kristin Taylor, 23, was arrested on Sunday and charged with aggravated domestic assault after she allegedly threatened her sisters and mother with a broken glass shard and a broom. When police responded to the residence on the 8900 block of Afton Lane, they found the victims had locked themselves in a bedroom. Officers spoke with the sisters through a window and were ... (click for more)
More than a dozen family members gathered in court on Wednesday to hear that Jamichael Harris, a man who is on pretrial house arrest for the June, 2014 murder of Inez Burney, will be allowed to attend Trinity Baptist Church on Sundays and Wednesdays while he awaits trial. Judge Steelman previously reduced Harris' bond on July 1 from $500,000 to $100,000 so that his family ... (click for more)
Sheriff Hammond is exactly correct on the Muslims in Tennessee. He sees with clear eyes the problem with the Muslims in our state and country. They do want to take over Tennessee. Our politicians are selling us down the river and allowing the trouble makers to dig in like tics and suck out the life's blood of our Constitution and take us over. They ... (click for more)
There is a website known as Grammarly that just completed a profound study. An automated proof-reading company (who I hope never finds out about me) collected 100 comments that each included over 50 words from the comment blogs of the nation's preseason Top 25 college football teams. Then they fed them into the company's huge algorithm computer and checked each fan base for punctuation, ... (click for more)
If Sale Creek's Bailey Pugh and Ariana Smith were a comedy act, Pugh would be Ed McMahan and Smith would play Johnny Carson. On the court, Pugh sets up Smith, who finishes things with killer punch lines. That was certainly the case Tuesday at East Ridge High School where the visiting Lady Panthers rolled over the Lady Pioneers, 3-0, with game scores of 25-16, 25-8 and ... (click for more)
There were a couple of first-time winners on Tuesday afternoon at Camp Jordan as the Chattanooga Cross Country League had its first official meet of the season. It was plenty hot and the humidity was relentless, so race officials decided to shorten the first race from the customary 5K distance to a two-mile test. The heat didn't seem to bother the overall winners as Signal ... (click for more)