text:
Preparation giving a controlled and extended release of both a dihydropyridine, e.g. felodipine and a β-adrenoreceptor antagonist, namely metoprolol as well as a method for the manufacture of the new preparation.
1. A controlled release preparation for administration once daily and containing a combination of metoprolol and a poorly water soluble a dihydropyridine being a calcium channel blocking agent, wherein metoprolol is included in the form of small beads containing as the main soluble component a salt of metoprolol coated with a waterinsoluble polymeric membrane and the dihydropyridine is dispersed in a non-ionic solubilizer and whereby both the dispersed dihydropyridine and the beads containing metoprolol are incorporated into a matrix forming a swelling gel in contact with water.
2. A preparation according to claim 1 wherein the non-ionic solubilizer is selected from the group polyethoxylated castor oil, polyethoxylated hydrogenated castor oil, polyethoxylated fatty acid from castor oil or polyethoxylated fatty acid from hydrogenated castor oil.
3. A preparation according to claim 1 wherein the non-ionic solubilizer is esters of hydrogenated castor oil fatty acids with oxyethylated glycerine.
4. A preparation according to claim 1 wherein the dihydropyridine is felodipine.
5. A preparation according to claim 1 wherein the dihydropyridine is nifedipine.
6. A preparation according to claim 1 wherein the gel-forming matrix contains hydroxypropyl methylcellulose.
7. A preparation according to claim 1 wherein metoprolol is in the form of its succinate.
8. A preparation according to claim 1 wherein the amount of the dihydropyridine varies between 2.5 mg and 80 mg and the amount of metoprolol succinate racemate between 40 mg and 200 mg.
9. A preparation according to claim 1 wherein metoprolol is in the form of the sorbate of the S-enantiomer and the amount varies between 25 mg and 120 mg.
10. A preparation according to claim 1 wherein metoprolol is in the form of the bensoate or sorbate of the S-enantiomer of metoprolol.
11. A process for the manufacture of a controlled release preparation containing a combination of metoprolol and a poorly water soluble calcium channel blocking agent of the dihydropyridine type characterized in that metoprolol is included in the form of small beads containing as the main soluble component a salt of metoprolol and said beads are spray-coated with a waterinsoluble polymeric membrane, containing derivatives of cellulose without protolysable groups and that said dihydropyridine is dispersed in a non-ionic solubilizer, whereafter both the beads and the dihydropyridine are incorporated into a matrix forming a swelling gel in contact with water.
The present invention is related to pharmaceutical extended-release preparations of two drugs of which one is a poorly water soluble compound, namely a calcium channel blocking agent of the dihydropyridine type, and the other is a salt of the β-adrenoreceptor antagonist metoprolol, and to methods of preparing such preparations.
The object of this invention is to obtain a solid preparation with a high extent of bioavailability of the two drugs in combination with an extended absorption from the gastrointestinal tract thus acheiving an even effect over 24 hours after once daily administration.
The pharmacological agents calcium antagonists of the dihydropyridine type and β-adrenoreceptor antagonists are widely used in the treatment of cardiovascular disorders.
The mentioned dihydropyridines, e.g. felodipine, nifedipine and nitrendipine, are commonly used in the treatment of cardiovascular disorders like arterial hypertension and ischemic heart disease. The dihydropyridines reduce vascular resistance and load of the heart through a direct effect on the smooth muscles of the blood vessels. The dihydropyridines are characterized by an extremely low solubility in water and for such drugs a low and variable extent of absorption is often seen as the dissolution of the drug in vivo may be rate-limiting.
Several ways to increase drug absorption have been described in the prior litterature. One way is described in No. DE-A-3024858, where a sparingly soluble substituted dihydropyridine, nicardipine, is used in its amorphous form in order to obtain increased absorption of the active compound from the intestine. Another way is described in No. EP-A-47899, where very small crystals of a practically insoluble dihydropyridine, nifedipine, have been used in order to increase the extent of the bioavailability. These methods and others are also described in "Techniques of solubilization of drugs", Ed S. H. Yalkowsky in Drugs and the pharmaceutical sciences, Vol 12. Of particular relevance to the present invention is that surfactant solubilizing agents may be employed in order to increase the bioavailability of the drugs with very low solubility. It is stated that the improvement of absorption properties can be ascribed to three processes: (1) increased wetting (2) increased permeability of membranes and (3) solubilization.
In vivo, the plasma concentration versus time profile after administration of dihydropyridine conventional tablets is characterized by high peak concentrations and comparatively low trough levels. The blood pressure response mirrors the plasma concentration curve, i.e. there is a pronounced effect at the time of the peak and a much less effect after 24 hours. Accordingly, a conventional tablet is not optimal for once daily administration and the more even plasma concentrations produced by a controlled release preparation of high quality would be preferred.
Conventionally, controlled and extended release is achieved by controlling dissolution and/or diffusion of medicament from the dosage form. Several materials are employed for this purpose e.g waxes, fatty materials, polymers, natural, synthetic and semisynthetic gums. Among the gums, hydroxypropyl methylcellulose (HPMC) constitutes an important class because of its pH-independent properties as well as its semisynthetic origin. A review of cellulose ethers in hydrophilic matrices for oral controlled release dosage forms is given by Alderman D.A. Int.J.Pharm. Tech. & Prod. Mfr (1984), 5(3) 1-9. The chemical treatment of HPMC to generate a desired constitution and the use of these qualities are disclosed in U.S. Pat. Nos. 3,870,790, 4,226,849, 4,357,469 and 4,369,172. SE-A-8008646-5 describes a combination of HPMC and hydroxypropyl cellulose which is used to control the release rate of a pharmaceutically active compound.
When a hydrophilic matrix is used the soluble polymer forms a gelatinous layer around the tablet after exposure to gastro-intestinal fluids or saliva. The release of the drug is limited by the rate of water penetration into, and diffusion of drug through, the gel formed (Bamba et al. Int.J.Pharm. (1979),2,307). Erosion of the gel structure is also an important release mechanism of a drug from the system. The polymers used have to hydrate rapidly in order to protect the tablet from fast dissintegration (Alderman 1984).
Drugs with a very low solubility in water may be poorly absorbed from the gastro-intestinal tract due to incomplete or slow dissolution. Consequently it is difficult to increase the duration of effect through a controlled slow dissolution of such a drug without lowering the bioavailability (Bogentoft C and Sjogren J, Towards Better Safety of Drugs and Pharmaceutical Products, Editor D.D. Breimer, 1980 Elsevier/North Holland Biomedical Press).
The β-adrenoreceptor antagonists block the adrenergic stimulation of the heart and thus reduce the oxygen demand of the cardiac tissue. Apparently, this explains their beneficial effects in angina pectoris and cardioprotective action in myocardial infarction. In addition, β-adrenoreceptor antagonists normalize blood pressure in a large proportion of patients with arterial hypertension which probably is due to an additional action on the control of peripheral resistance to blood-flow. For patients treated with β-adrenoreceptor antagonists for cardiovascular disorders it is advantageous to have a constant concentration of the administered drug in the blood. For dosage once a day the β-adrenoreceptor antagonist metoprolol has been incorporated in controlled release tablets of the insoluble matrix type, e.g. Durules®. However, the drug release from the matrix tablets is not satisfying as about 50 % of the dose is released within a few hours after administration. For a drug like metoprolol with a comparatively short half-life a slower release rate is required in order to obtain even plasma concentrations over 24 hours. A constant release of metoprolol over 20-24 hours would be preferred. A preparation of metoprolol with such properties is described in No. EP-A-220 143.
It has been shown that a combination of a β-adrenoreceptor antagonist and a vasodilating dihydropyridine is of advantage in many hypertensive patients since the two agents have synergistic effects (Hansson BG et al, Drugs 1985:29 (suppl 2); 131-135, Eggerston R and Hansson L Eur. J. Clin. Pharmacol 1982:21;389-390). In addition to the synergistic effects, a co-administration offers advantages regarding decrease in unwanted reflex counteractions elicited by either drug when administered alone (Dean S. and Kendall M. J. Eur. J. Clin. Pharmacol 1983:24;1-5).
Immediate release solid dosage forms of the fixed combination of a dihydropyridine derivative and a β-adrenoreceptor antagonist with improved bioavailability are described in No. EP-A-163984.
However, a fixed combination of the two drugs in a preparation producing reproducible and even plasma concentrations of both drugs over the dosage interval after once daily administration has not been available. The large difference in physical-chemical properties between the two drugs makes it extremely difficult to obtain a suitable preparation based on conventional controlled release systems. A controlled release preparation of the two drugs would improve therapy through less frequent administration and improved patient compliance, (cf Hayes R. B. et al. Clin.Pharm. Ther (1977), 22, p. 125-130) may be obtained with controlled-release dosage forms. Although there has been a need for a controlled release preparation, expressed as far back as in 1977, for a once daily administration of the two drugs, such a preparation has not been available until the present inventors developed the preparation described in the following text.
FIGS. 1 and 2 shows the means plasma curves as well the average concentrations in plasma after administration of single doses for felodipine and metoprolol respectively.
It is the object of the present invention to provide a preparation giving a high and reproducible extent of absorption as well as even plasma concentration during 24 hours after once daily administration of both a poorly water soluble calcium channel blocking agent of the dihydropyridine type, e.g. felodipine or nifedipine and a β-adrenoreceptor antagonist, namely a salt of metoprolol. As a conventional controlled release preparation cannot give the desired release properties of the two drugs simultaneously it has been necessary to develop a new type of controlled release preparation, which utilises more than one mechanism for controlling the release of the active ingredients. The two drugs are because of that incorporated into one product utilizing two separate mechanisms for controlling the release of the two active ingredients, namely one for the dihydropyridine part and one for the β-adrenoreceptor antagonist part.
The dihydropyridine compounds suitable for the controlled release preparations according to the invention are poorly soluble dihydropyridine compounds. The invention is especially advantageous for compounds with a solubility of less than 0.1 per cent by weight in water and which are solubilizable in a solubilizer of choice or in a combination of a solubilizer and water. Examples of drugs suitable according to the invention are some substituted dihydropyridines, such as nifedipine and felodipine. Felodipine is 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester. Nifedipine is 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester. Other examples are nimodipine, nisoldipine and nitrendipine.
The dihydropyridine is mixed with a hydrophilic swelling agent, e.g. hydroxypropyl methylcellulose (HPMC). From this mixture solid dosage forms such as tablets or capsules are prepared. When such a preparation comes in contact with water it forms a swollen gel matrix, out of which the drug is slowly released.
Among different hydrophilic materials tested, HPMC is a suitable gel-forming material. Other suitable examples of hydrophilic substances are guar gum, xanthan gum, carboxymethylen and different cellulosic materials e.g. sodium carboxymethylcellulose and hydroxypropyl cellulose.
It is preferable to mainly use HPMC having a hydroxypropoxy content of 4-12 weight-%, especially about 8.5 weight-% and a viscosity lower than 100 cps. HPMC of higher viscosity may be added to achieve the optimal rate of drug release. The viscosity is measured by a standardized method described e.g in United States Pharmacopoeia XXI, 1985, p. 672.
The dihydropyridine is preferably dispersed in a non-ionic solubilizer before incorporation into the matrix. The solubilizer permits dilution with water or intestinal fluids without the dihydropyridine being transformed into a poorly absorbable form. The choice of solubilizer is critical. With some commonly used solubilizers or co-solvents dilution may cause precipitation of the drug. The mixture of the dihydropyridine and the solubilizer is incorporated into a hydrophilic gel matrix, which gives a prolonged and controlled release of the drug.
The solubilizers suitable for the controlled-release of dihydropyridines according to the invention are non-ionic surface-active agents, especially such containing polyethyleneglycols as esters or ethers. They are preferably chosen from polyethoxylated fatty acids, hydroxylated fatty acids and fatty alcohols. It is especially preferred to choose the solubilizer from the group polyethoxylated castor oil, polyethoxylated hydrogenated castor oil, polyethoxylated fatty acid from castor oil or polyethoxylated fatty acid from hydrogenated castor oil. Particularly preferred solubilizers are esters of hydrogenated castor oil fatty acids with oxyethylated glycerine, e.g. polyoxyl 40 hydrogenated castor oil. Commercially available solubilizers, which can be used are known under trade names Cremophor, Myrj, Polyoxyl 40 stearate, Emerest 2675 and Lipal 395.
In the preparation according to the invention the proportion between the solubilizer and the dihydropyridine will be 10:1 or lower, preferably 6:1 or lower.
The β-adrenoreceptor blocking agent is incorporated into the gel system described above in the form of coated beads of active component having a controlled release of the β-adrenoreceptor blocking agent metoprolol during at least 15 hours. This is achieved by preparing a large number of small, preferably compact, particles all comprising a salt of metoprolol as the main soluble component and coated with a water insoluble polymeric membrane. The preferred coating contains non protolysable derivatives of cellulose groups as the main constituent.
The small particles, beads, containing metoprolol have a size of 0.25.2
mm, preferably 0.35-1.0 mm. The beads may consist of the metropolol salt alone or mixed with insoluble excipients or insoluble cores coated with the metoprolol salt.
Metoprolol in the preparation is in the form of the racemate or one of the enantiomers, preferably the S-isomer. Suitable soluble salts of metoprolol have a solubility of less than 600 mg/ml in water at 25° C., preferably 30-600 mg/ml in water at 25° C. Examples of suitable salts are salts formed of organic carboxylic acids, preferably of low molecular weight. Especially preferred are the succinate, fumarate or bensoate of racemic metoprolol and the bensoate or sorbate of the S-enantiomer of metoprolol.
Examples of suitable polymeric materials for coating of the beads are soluble or insoluble derivatives of cell without protolysable groups or acrylic resins like Eudragit RL®, Eudragit RS®, alone or in combination. Especially preferred are ethylcellulose in combination with hydroxypropyl methylcellulose or hydroxypropyl cellulose.
The coated beads containing metoprolol described above and which according to the present invention are incorporated into the gel system containing a dihydropyridine are earlier described in No. EP-A-220143. In No. EP-A-220143 it is also described that said beads are a suitable way of preparing a long-acting preparation of metoprolol.
The final preparation is preferably in the form of a tablet, which in the gel-forming matrix contains both the dihydropyridine as well as the metoprolol beads. The metoprolol beads constitute 10-60 weight-%, and the gel forming agents constitute 20-80 weight-% of the preparation. The technical properties of the described controlled release system are excellent, making it very suitable for large scale production. The tablets may optionally be filmcoated to improve appearance and stability.
In vivo, the degree of drug absorption is both high and reproducible. The concentration of drug in plasma and effect over time are governed by the rate of drug release from the system. The release of the dihydropyridine is determined by the properties of the gel forming agents and can be extended over periods up to 24 hours. The rate of release is easily changed to suit a certain dihydropyridine by the use of different types and amounts of gel forming agents of varying properties e.g. viscosity, and gel-strength. The rate of release of metoprolol from the metoprolol beads is modified mainly by the composition and thickness of the polymeric membrane. The release of metoprolol is generally extended over 16-24 hours.
By a careful choice of fillers and binders as well as gel forming material the preparation is manufactured into a commercially acceptable form, e.g. a tablet that shows unexpectedly good absorption of both active compounds as well as a prolonged duration of action.
In the examples below preparations according to the present invention contain 10-20 mg of the dihydropyridine and 95 mg metoprolol succinate. However, depending on the dihydropyridine used and the condition to be treated, the amounts will generally be between 2.5 mg and 80 mg for the dihydropyridine and between 40 and 200 mg for metoprolol racemate as the succinate salt. When the S-enantiomer of metoprolol as the sorbate salt is included the corresponding amounts are between 25 to 120 mg. With other metoprolol salts the amounts will differ in relation to the molecular weight of the salt.
______________________________________ g______________________________________Felodipine 10Polyoxyl 40 25hydrogenated castor oilPolyvidon K90 24Hydroxypropyl methylcellulose 230Aluminum silicate 94Lactose 56Cellulose, microcrystalline 6Metoprolol succinate 95SiO2 24Ethylcellulose 32Hydroxypropyl methylcellulose 8______________________________________
The composition according to Example 1 was formed to a tablet containing 10 mg of felodipine and 95 mg metoprolol succinate per tablet. The tablets were prepared in the following way:
I. Felodipine was dissolved in polyoxyl 40 hydrogenated castor oil and the solution obtained was carefully mixed with the carrier materials, HPMC, polyvidone K90, aluminium silicate, lactose and microcrystalline cellulose. The mixture was granulated with ethanol and dried.
II. Metoprolol was sprayed onto cores of silicon dioxide to form beads of 0.5 mm diameter. The beads were coated with a polymeric film by spraying a solution of ethylcellulose and HPMC in methylene chloride and isopropanol onto the beads in a fluidized bed.
I and II were mixed, a lubricant was added and tablets were made by compression in a tablet machine.
The dissolution of both felodipine and metoprolol from the tablet is given in Table 1.
TABLE 1______________________________________Cumulative in vitro dissolution of felodipine and metoprolol ina phosphate buffer of pH 6.5 with 1% sodium dodecylsulphate.Method: USP dissolution apparatus No. 2, 50 rpm. Percent released over time (h) 0 2 4 8 12 16 20______________________________________felodipine 0 14 32 64 88 96 98metoprolol 0 5 16 39 65 86 95______________________________________Example 2 g______________________________________Nifedipine 20Myrj 51 50Hydroxypropyl methylcellulose 200Xanthan gum 15Guar gum 15Carboxypolymethylene 4Aluminum silicate 100Metoprolol succinate 95SiO2 24Ethylcellulose 23______________________________________
The composition according to Example 2 was formed to a tablet containing 20 mg of nifedipine and 95 mg of metoprolol succinate. The tablets were prepared as follows:
I. Nifedipine was dissolved in Myrj 51 and the solution obtained was carefully mixed with the carrier materials, HPMC, xanthan gum, guar gum, carboxypolymethylene and aluminium silicate. The mixture was granulated with ethanol and dried.
II. Metoprolol was sprayed onto cores of silicon dioxide to form beads of 0.5 mm in diameter and coated with a polymeric film of ethylcellulose as described in Example 1.
and II were mixed, a lubricant was added and tablets made by compression in a tablet machine.
The in vitro dissolution of both nifedipine and metoprolol from the tablet was extended, see Table 2.
TABLE 2______________________________________Cumulative in vitro dissolution of nifedipine and metroprolol in aphosphate buffer of pH 6.5 with 1% sodium dodecylsulphate.Method: USP dissolution apparatus No. 2, 100 rpm. Percent released over time (h) 0 2 4 8 12 16 20______________________________________nifedipine 0 12 26 44 72 90 98metoprolol 0 6 16 34 50 62 75______________________________________
At present both Example 1 and Example 2 are considered to be equally good modes of carrying out the invention.
The following reference examples describe different preparations used in the biopharmaceutical studies. Reference example A illustrates conventional tablets. Reference example B illustrates a preparation, wherein metoprolol has been incorporated into a formulation especially suitable for dihydropyridines and Reference example C illustrates a preparation, wherein felodipine has been incorporated into a controlled release pellet preparation.
Reference example A
Felodipine 10 mg conventional tablets and
Metoprolol 100 mg conventional tablets (100 mg metoprolol tartrate
corresponds to 95 mg metoprolol succinate)
Reference example B
______________________________________ g______________________________________Metoprolol succinate 95Polyoxyl 40 hydrogenated 25castor oilHydroxypropyl methylcellulose 230Aluminum silicate 94______________________________________
The composition according to Reference example B was formed to hydrophilic matrix tablets containing 95 mg metoprolol succinate per tablet. The tables were prepared in the following way:
Metroprolol was mixed with polyoxyl 40 hydrogenated castor oil and then carefully mixed with the carrier materials, HPMC and aluminium silicate. The mixture was granulated with ethanol and dried. A lubricant was added and tablets were made by compression in a tablet machine.
The dissolution rate in vitro from this tablet is shown in Table 3.
TABLE 3______________________________________Cumulative in vitro dissolution of metoprolol in a phosphate bufferpH 6.8.Method: USP dissolution apparatus No. 2, 50 rpm.______________________________________Percent released over time (h)0 1 4 8 12 20______________________________________0 23 59 86 99 100______________________________________Reference example C g______________________________________Felodipine 66Methylcellulose 13Mannitol 870Polyvinylpyrrolidone 30Cellulose, microcrystalline 40Ethylcellulose 34Polyethyleneglycol 41.8______________________________________
The composition according to Reference example C was formed to controlled release capsules containing 10 mg of felodipine per capsule. The capsules were prepared in the following way:
Felodipine was micronized and carefully mixed with the carrier, mannitol, methylcellulose, polyvinylpyrrolidone and cellulose. The mixture was moistened with water and spheronized. The granules obtained were dried and sieved, the fraction 0.71-1.12 was used. The fraction was coated with ethylcellulose and polyethylenglycol dissolved in a mixture of methylene chloride and isopropylalcohol. The coated granules were filled into hard gelatine capsules. In vitro, the release of felodipine from the granules was similar to that of the tablet of Example 1.
Biopharmaceutical studies
The extended-release preparation (ER) according to Example 1 was given as a single dose to 12 healthy subjects. In FIG. 1 and 2 the mean plasma curves produced for felodipine and metoprolol as the fixed combination tablet (ER) are shown. The obtained concentration of both drugs in plasma will result in an even effect over 24 hours during continuous therapy.
In FIG. 1 and 2 also the average concentrations of felodipine and metoprolol in plasma after administration of single doses of the conventional tablets, Reference example A, are compared with those after administration of the preparation in Example 1. The metoprolol conventional tablet was given to 10 volunteers and the felodipine conventional tablet to 12 volunteers.
The pellets of Reference example C were given to 6 healthy subjects as a single dose. Plasma samples were taken after 0.5, 1, 2, 3, 4, 6, 8 and 10 hours. In none of the samples could any felodipine be detected.
The preparation according to the invention gives a virtually constant and extended release of both felodipine and metoprolol in vitro, Table 1. The corresponding in vivo data shows that the product also gives a controlled and even concentration of both drugs in plasma, FIG. 1 and 2. The advantage of the formulation according to the invention is obvious when comparing the mentioned in vivo data with those after administration of conventional tablets, FIG. 1 and 2. With conventional tablets the concentration of drug plasma is very low 24 hours after administration and in consequence little or no effect may be anticipated. Also the fixed combination of nifedipine and metoprolol in a formulation according to the invention gives the desired extended release of both drugs, cf. Table 2.
As demonstrated by the fast in vitro release of metoprolol from the dosage form of Reference example B, cf. Table 3, it is not possible to achieve the desired release profile over a 20 hour period by just incorporating a metoprolol salt in the hydrophilic swelling matrix used for the dihydropyridine part of the invention. In parallel, it has not been possible to obtain acceptable dihydropyridine plasma levels from a product where the drug without solubilizer is incorporated into coated beads. An in vivo study in healthy subjects of Reference example C gave no detectable levels of felodipine in plasma, cf. above.
To decrease the fluctuation of plasma levels, and to permit once daily dosing of a dihydropyridine derivative and metoprolol an extended release of both drugs is required. This cannot be achieved by use of one single kind of controlled release system according to the prior art. Thus, the present invention which makes use of two separate kinds of controlled release systems incorporated into one unique and new dosage form provides both good absorption and long-effect duration of the two drugs.
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Excellent lesson this afternoon.
I followed the plan and came in, waiting for him to notice and acknowlege me, standing just out of range beside the stall, talking to my neighbor, gathering up our stuff/grooming tools/reins/etc but not going in. He's big and wide (too much grass lately I think), so he had to move his hind quarters to the side to see me. And he did. I went in, very easy...said hello and gently touched his flank. I fed him a nice apple quarter and then slowly started grooming. This time I did not speak conversationally, but kept my voice down, almost whispering to him. He was obviously happy to see me. But I didn't let that make me excited or happier. I stayed calm and cool.
The difference was dramatic. He actually helped me get his bridle on, opening his mouth wide. It was hilarious. He's SUCH a great horse!
We had moments when he still wasn't understanding me, but it's okay. The chief instructor was there today helping with my issue with steering him and showing me how to press his side and let go. Press and as soon as he even moves in that direction, to let go. (I had sent her an email over the weekend, describing my difficulties and concerns as I did with you all and she and I had a short discussion beforehand).
There is another student who has the same concerns as I, although he is far more experienced with horses (just not riding). He and I are not big believers in the kick. I know it has it's place but it's not a solution to a horse not understanding what you're telling him in the first place. We feel it's on us to convey properly.
ESPECIALLY BECAUSE we have been assigned the best of the best horses at this stable (and this is a seriously excellent fascility. I won't name it but you'd know it if I did.) we are given the easiest horses to ride, meaning the most patient and experienced. And if we can't communicate with THESE horses, these highly trained horses, then it's time to hang up the proverbial hat. And for me - well, I'm not about to do that by a long shot.
So thank you for all your kind words of encouragment, your advice and your assistance. Today was a good day thanks to you (particularly you, Tiny) (big hug from here). :)


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Jerre K. Iversen, Vice President for University Advancement
UT Tyler University Advancement
Jerre Iversen has been in professional fundraising since 1982. After eight years in hospital development and as a fund raising consultant, he went to Baylor College of Medicine in Houston as director of major gifts and second-in-command of development operations. He then became executive director of development at Georgetown University Medical Center.
From there he went to Yale University School of Medicine as executive director of development. In 2001 he returned to Texas as vice president of development at The University of Texas Health Science Center at Houston. Under his leadership, volunteers and advancement staffs have raised half a billion dollars for education and medical research.
Highlights include a $175-million campaign at Baylor College of Medicine ($182 million raised); setting a new fundraising record for Yale University School of Medicine (final year there realized $77 million); a $200-million campaign at The University of Texas Health Science Center at Houston ($204 million raised); and more than doubling the fundraising totals at Georgetown University Medical Center.
You can reach Jerre at 903.566.7110 or firstname.lastname@example.com


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Doesn't matter if your regional disaster is a flood, tornado, hurricane, snowpocalypse, or earthquake, when the next one strikes you're going to need to be ready for it. Here's what you should have on hand to keep you and yours safe for at least three days. »


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Want to continue to bring the principles of Catholic social teaching to bear on the public policy making process on key issues in Washington and Albany?
Here are some helpful organizations for your reference:
Catholic Advocacy Network of the New York State Catholic Conference of Bishops
This is the official public policy voice of the Catholic Church in New York State. To become a member of the Catholic Advocacy Network just click on the following link and click on "Join the Network."
Catholic Community Relations Council of New York (CCRCNY)
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Cicilia Lace Dress
Style # 225130
AVAILABILITY: Unavailable for immediate shipment.
Stellar in lace. Mesh net shoulders, arms, and hemline, our fitted dress kisses your curvature and highlights your hourglass figure. Large open keyhole back that's a must with flyaway earrings and stilettos.
- 92% Nylon, 8% spandex
- Hand wash
- Made in USA
- Center back to hem: 32.75" (81 cm)
- Model is 5'10" and wears a US size S
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Click Here to Watch the Whole Video in HD at Club Inferno Dungeon
The Filthiest Buttplay On The Net! Premium Members get full access to first-run Club Inferno movies before they are available in stores or anywhere else online.
Jackson Lawless gets on all fours and teases Tom Colt by showing him his twitching hole. Colt, an intimidating hairy, tattooed top, steps up and immediately begins prying open Jackson's tight asshole with his mammoth greased up paws. Colt manhandles the willing pig-bottom, shoving his fist deeper and deeper inside Jackson's ass. Just as the bartender announces "last call," Jackson blows his load all over the pool table.
Pixels: 320X240 | Bitrate: 350K
Pixels: 640X480 | Bitrate: 700K


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The Virago book of ghost stories
McGraw-Hill, 1988 - Fiction - 331 pages
Gathers ghost stories by Edith Wharton, Etten Glasgow, Norah Lofts, Fay Weldon, and Mary Webb
From inside the book
8 pages matching Stella Gibbons in this book
Page 334
Where's the rest of this book?
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Review: The Virago Book of Ghost Stories (The Virago Book)User Review - Georgie - Goodreads
Good collection of ghost stories. My favourites were: The Story of Salome - Amelia B. Edwards - loved the setting of Venice, atmospheric and creepy The Vacant Lot - Mary E. Wilkins - disturbing story ... Read full review
Review: The Virago Book of Ghost Stories (The Virago Book)User Review - Reformed_druid - Goodreads
It had a bit of a slow start with the first few stories being not the best I have ever read. After you get a couple of stories in though it gets quite good. Many of the stories included are very good indeed. Very imaginative reading. Read full review
E Nesbit the violet car
May Sinclair the token
Marjory E Lambe G G Trenery the return
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Angela Carter asked aunt began believe chair child Clifford cold Daily Standard dark dead dear Deidre Doctor Maradick Donald door E. M. Delafield Edith Wharton Elizabeth Bowen Elizabeth Jane Howard Elizabeth Taylor empty Enid Bagnold eyes face Fay Weldon fear feel felt frightened ghost stories girl gone hair hand happened head hear heard Henrietta Hilary John Kate kitchen knew lady laughed light looked madame Marjorie Bowen mind Miss de Mannering morning mother never night Norah Lofts Nurse Webber once Pamela Hansford Johnson poor Primrose remember Rose Macaulay round Sarah saucepan schoolroom seemed seen Sharon silence smile Sophy Mason sound stairs stared Stella Gibbons stood stopped Strutt suddenly sure Tallent tell there's thing thought told took Trevanion turned voice waiting walked window woman women wonder young


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Event Details
Multiple Days: 09/24/2012, 09/27/2012, 09/28/2012, 09/29/2012, 10/01/2012, 10/04/2012, 10/05/2012, 10/06/2012Location: Belle Grove Plantation 336 Belle Grove Road, Middletown, VA 22645 Time: 11:30 AM to 12:00 PM Fee Information: Free
A Park Overview Program A 30 minute orientation program on the history and settlement of the Shenandoah Valley, the Battle of Cedar Creek and the impact of the Civil War on the local community. This interactive program uses the surrounding landscape features and various props (taken from a box) to "create" the park and tell its many stories by literally placing visitors "in the middle of the park." Great for kids and adults alike! Meet near the picnic area on Belle Grove's front lawn.


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SIS Department International Studies Program Objectives(modified 26 March 2007)
To meet the educational needs of the students and prepare them with the knowledge and skills needed in a global environment. Students should be well versed in the background and issues of the international community, linguistic skills, and the requirements of a global work environment.
1. To provide graduates with the methodological skills, both quantitative and qualitative, to conduct research and analysis and effectively communicate the results of their research.
2. To provide graduates with a thorough grounding in both national and international issues and their historical backgrounds, whether of a political, economic, or social nature.
3. To provide graduates with the ability to communicate effectively on a novice level in a second language, and an understanding of the importance of language and culture in all areas of relationship and human endeavor.
4. To provide graduates with the skills necessary to work effectively in an environment that requires cross-cultural competence.
5. To provide graduates with the professional competence and the personal confidence to operate effectively in the workplace or in graduate school and to build international cooperation and understanding.


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SACRAMENTO, CA - Fire crews have recovered a person found floating facedown in the American River Friday afternoon.
The person was taken out of the water a mile and a half downriver from the Sunrise Boulevard bridge, according to the Sacramento Metro Fire District.
The victim was not wearing a life vest and not floatation devices were seen in the area, crews said.
Rescuers said the person did not have pulse. CPR was performed until an air ambulance arrived to take the person to Mercy San Juan Medical Center.
The rescue call went out about 1:30 p.m.
The person's condition was unknown.


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- height: 6'1" (185 cm)
- DOB: Unknown
- weight: 170 lbs (77.11 kgs)
Fight History
|Bellator 38
|Tim Galluzzi
|Won submission (triangle choke)
|Rounds: 1
Time: 1:04
|Bellator 38
|Tim Galluzzi
|Won submission (triangle choke)
|Rounds: 1
Time: 1:04
A lightweight matchup of Luciano Dos Santos vs. Eric Reynolds and a welterweight bout of Charles Blanchard vs. Corey Hill will serve as the featured matchups of April's
In what would prove to be the third major upset of the evening, Tim Carpenter scored a victory over Daniel Gracie and advanced past the opening round of Bel
All eight fighters competing in Bellator Fighting Championships' light-heavyweight tournament successfully have made weight for Saturday's opening round. Th
Bellator Fighting Championships officials today announced the five-fight "local feature" card for this week's Bellator 38 event, and recent signee Blagoi Ivanov heads the
As is customary, the Tennessee Athletic Commission issued medical suspensions to all fighters who competed at this past weekend's "Strikeforce: Nashville" event.
NASHVILLE, Tenn. – According to most MMA pundits, Strikeforce middleweight champion Jake Shields had one path to victory against UFC import Dan Henderson in their main ev
NASHVILLE, Tenn. – MMAjunkie.com is on scene and reporting live from today's "Strikeforce: Nashville" event. Today's show takes place at
On a fight card that features three title fights, much of attention is focused on a "Strikeforce: Nashville" headliner between middleweight champion Jake
NASHVILLE, Tenn. – MMAjunkie.com was on scene for today's "Strikeforce: Nashville" official fighter weigh-ins and captured images of all 20 event competito
NASHVILLE, Tenn. – MMAjunkie.com was on scene for today's official "Strikeforce: Nashville" fighter weigh-ins. Today's festivities took pl
Bridgestone Plaza at Bridgestone Arena in downtown Nashville, Tenn., hosts Friday's official fighter weigh-ins for "Strikeforce: Nashville." The festiv
With just less than two weeks until Strikeforce makes its return to network television with "Strikeforce: Nashville," the promotion today announced five preliminary bouts
The non-televised portion of Strikeforce's second network-televised card is all but filled. In addition to a middleweight matchup between Hunter Worsham a


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Vizz Media API
Vizz Media is a mobile marketing service that offers bulk SMS solutions. It allows users to send bulk SMS to more than 10,000 people with one click. Vizz Media supports both two-way SMS and Flash SMS. Users can send single or bulk SMS directly through the website or programmatically via REST or SMPP API. The API also allows users to get delivery reports for their messages.
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Find us on Facebook
Islamabad is the capital city of Pakistan , and is located in the Potohar Plateau in the northwest of the country. It is located within the Islamabad Capital Territory , though the area has historically been a part of the crossroads of the Punjab region and the North-West Frontier Province. Islamabad is located at 33°40′N, 73°10′E . The city was built during the 1960s to replace Karachi as Pakistan 's capital . Islamabad is a rather modern and clean city, especially in comparison to other cities in Pakistan. A Greek firm of architects, Doxiadis Associates, drew up a master plan, triangular in shape based on a grid system with its apex towards the Margalla Hills . Rawalpindi is considered its sister city due to the close proximity of the two cities.
This city was built for several reasons: The development of the country was focused on Karachi and President Ayub Khan wanted it to be equally distributed; Karachi was vulnerable to attack from the sea in an event of a war with India; and Islamabad by contrast is safely surrounded by the mountains. The climate in Islamabad is favourable compared to Karachi with lower average temperatures throughout the year. It was also closer to the GHQ which was, and still is in Rawalpindi.
Islamabad was divided into eight zones: the diplomatic enclave, the commercial district, the educational sector, the industrial area and so on, each with its own shopping area and park. Islamabad is also home to the Faisal Mosque which is well known for its architecture and immense size. The mosque was gifted by King Faisal of Saudi Arabia .
About Author:
Shehzina is an MBA student in Bahria University. She has interests ranging from design to travel. She is also an avid photographer and want to share more of her creative work.


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Mar 7th
Tomb Raider Gets Three New Multiplayer Maps, Timed Xbox 360 Exclusive
Multiplayer Arenas Coming Later This Month
Square Enix has revealed the first batch of DLC for the new Tomb Raider reboot.
Featuring three new multiplayer arenas to fight it out in, the Caves & Cliffs map pack is a timed Xbox 360 exclusive release.
It will be available to download from Xbox Live on March 19 priced at 400 Microsoft Points (£3.43). The three new maps detailed below will be playable across all four of the game's online modes.
- Scavenger Caverns: An extensive subterranean network of caves used by the island's scavengers as an underground prison.
- Cliff Shantytown: This scavenger settlement was built high up on the island cliffs. Its many layers hide some of the deadliest traps on the island.
- The Burning Village: A raging fire has embraced an abandoned Japanese village, the burning buildings offer multiple ways to escape or engage your enemies.
Release dates for other platforms have yet to be announced.


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Pretty Little Liars
Pretty Little Liars Spoiler: "Big Moment" for Wren, Spencer, and Toby Coming Up?
Ever since Season 1 of Pretty Little Liars, we've been conflicted about Wren (Julian Morris). And, according to a new tweet from Julian, we'll soon be seeing more of Wren in a potentially disastrous situation.
Julian tweeted at Keegan Allen (Toby), "Big moment for Wren later... the carpenter's back." Of course, Wren and Toby are both competitors for Spencer's (Troian Bellisario) heart, even though all signs point to Spoby as a couple (as we reported, Spoby will share a kiss in the PLL Season 2 finale).
Troian re-tweeted Julian's message, saying "Take it easy boys." But Julian kept up the teasing by tweeting, "hard to when you're involved ;) x."
We most recently saw Wren in Season 2, Episode 21: "Breaking the Code," when he took care of (and made out with) a very drunk Spencer, letting her sleep on his couch and gazing at her longingly. Since we know that Toby returns on tonight's episode (Season 2, Episode 23: "Eye of the Beholder"), we think it's safe to say that "the carpenter" Julian is referring to is Toby.
Does this mean we'll finally see a Wren/Toby fight? Whose side will Spencer be on? Who would you be rooting for? Answers tonight, hopefully!
Catch an all-new Pretty Little Liars tonight, March 5 at 8 p.m. ET/PT on ABC Family.
Source: Twitter
Get your Pretty Little Liars fix: Like us on Facebook and Follow us on Twitter and Tumblr!


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Any talents, besides drumming?
View Single Post
Senior Member
Join Date: Mar 2007
Posts: 146
Re: Any talents, besides drumming?
I think of talents as something worthy of mentioning so I'm going to write down the things that I'm actually good at, I'm pretty proud of myself.
I'm an artist, I can draw pretty well.
I'm an excellent pixel artist, I don't do it much anymore but I can still make things look photo realistic in the tiniest of spaces.
I'm a national competing Kendo player, I stopped this too after something bad happened involving it. Maybe later when life is more scheduled I'll get into it again.
I can play guitar okay, I have a good sense of pitch, I use to play songs on my shinai back in Kendo. I like to figure out chords to make riffs and then eventually songs. My friends who are bunches better than me technically at guitar enjoy the stuff I make, I think that's pretty decent.
I can whistle to really high pitches, and past that I'm also really good at whistling. Like good enough for it to be listened too.
Also, I'm told often that I have talent when it comes to writing, but I don't think so and this post wouldn't show it.
I can get good at anything, I'm pretty proud of that.
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A Worldwide Day of Protest Against Discrimination
BY Advocate.com Editors
May 17 2013 1:59 PM ET
Serbian activists in central Belgrade mark the International Day Against Homophobia with rainbow colors. Two thirds of Europe's LGBT people are still afraid to be public about their identity, and a quarter have been victims of physical or verbal attacks, according to a European Union report released Friday.
Tags: Pride


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Apple can do more with Facebook, wouldn't have bought Instagram
When asked, as part of his D10 Conference interview, about the status of Apple's relationship with Facebook, Apple CEO Tim Cook said they could definitely do more.
Cook praised Facebook -- which just completed it's IPO -- as a great company, and one with which they enjoyed a good relationship, but also advised interviewer Walt Mossberg and the audience to "stay tuned" for more.
Because Facebook's user base is so big, Apple wants to make sure that those users are having the best Facebook experience possible on Apple products. This, of course, comes after Facebook integration was rumored to have been pulled from iOS 4 before it was released, and was very publicly yanked from Apple's Ping social music network after Facebook turned off API access.
When asked about Steve Jobs' comment that Facebook's terms for collaboration were "onerous", Cook countered that Facebook simply has their own way of doing things, and that many people say the same about Apple. While that's true, the nature of complaints about Facebook are different in kind than those about Apple -- mostly centered around privacy and ownership of personal informat
Whether or not that means the Apple/Facebook relationship has gotten better, especially considering rumors of Facebook hiring former Apple engineers to build a Facebook Phone, is hard to tell. Maybe we'll see some signs of it at WWDC 2012 next week when iOS 6 is expected to debut. If Facebook integration is part of the future of iOS devices, then obviously things have improved.
Cook also added that Apple wouldn't have bought Instagram the way Facebook did. As part of an ongoing discussion about Apple increasing their already legendary secrecy, Cook said he wouldn't even advise the world Apple bought a company if he didn't have to. Cook did say, however, that while Apple preferred smaller talent and IP based purchases, and ones that matched up with Apple product plans, he wouldn't rule anything out. Even an Instagram style purchase if one ever made sense.
Have something to say about this story? Leave a comment! Need help with something else? Ask in our forums!
Reader comments
Apple can do more with Facebook, wouldn't have bought Instagram
Agree it is ripe to bomb. Facebook has a serious competitor in G+, has huge profit margins that can't be maintained, has almost no assets of any value, puts out terrible software, and is a pretty long history of generally annoying the heck out of its user base.
Not to mention the slow realization people are coming to that when you know all the trivial everyday stuff your friends are whining about, over time your friends start to become awfully annoying.
I agree with you in everything, except calling G+ a "serious competitor"...it isn't.
I follow half as many people in my FB as in G+, and still I see several posts on FB every hour, when I have seen up to a day without any posts at all on G+, except from Robert Scrobble (that dude can't stop typing...I have no clue how he manages to breath, never mind anything else).
Twitter is more of a competitor to FB than G+, and they aren't even close...G+ is Google's Ping, but unlike Cook, they won't admit it.
My point being that G+ is better (IMO). It's downfall is the active user base, but considering its only a year old it's made pretty impressive progress. That makes it a serious threat. That doesn't mean it's a lock to overtake Facebook, or that it will happen overnight. But the potential is there.


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I think it a Black Woman's Problem. For the most part they have always been atracted to the agressive Male who is in many cases a take-charge type individuial who is mostly controlling. The Women think this typeof personality os good until they start getting beat on, but by that time they are in too deep, and are afraid of the Man.
Many Women don't realize that it might not be a good fix if a Male is up on her all the time to establish a relationship. A quality Male will usually give her space to "breathe". Women should avoid relationships where their partner is trying to controll every aspect of their life, and is always critical of what she do or don't do. For the most part, a Controlling Mate is an abusive Mate, and they should be avoided at all cost.
When are we going to stop talking the Electric Car to death. Why not have a morotoroum on the Talk, and get some out here on the street that the average person can afford, that would solve the whole problem. First they were to be introduced in early 2010, and now its late 2010, and there are only a few in a few places.
As long as we have had electric Golf Carts in this society, we should have had several electric cars 10 or 15 years ago. So enough with all the talk, and they should put a Car out here that sells for $20k or less that would be subsidized by the government so everybodu who wanted one could get one. They could make the $50k vehicles for those who could afford them, but they have to get enough moderate priced cars out here to make the entire program successful, Charging Stations, and new dealers, the whole program.
Foreclosures are a by-product of a bad economy which produces unemployment. Extending unemployment benefits or helping pay parts of ones mortgage are only temporary, stop-gap measures. People need permanent employment that will allow them to pay all of their bills.
However, most people in the Housing Business knew Housing Values were being inflated during the Boom years, but since those in power were making a lot of money, no one said anything, and now we all have to pay for this fraudulant activity.
Many people expect the Banks to take the Loss and write the Mortgage Balances down. However they fail to consider that the Bank paid the seller of the property the full sale price of the property. In otherwords, the Bank lent $100k and now the value has dropped to $70, so it's expected that the Bank should take a $30k loss, multiplied by thousands of Mortgages?
I'm not saying that the Bank was not responsible for the value or the Property or the amount of the Mortgage being inflated to $100k in the first place, but this is where we are at today. So it appears as if the Fed's decided to "quell" the status quo to keep from acquiring all those bad loans. However they didn't put in any safeguards to keep the same thing from happening again. At the same time we wont see Home ownership at the Rate we have seen it in the past. Low Income Purchasers will have a difficult time getting a Loan in the future.
Sammy: Your Post was the funniest i've seen on this topic. You and everyone else junps off trashing LeBron for going for a better deal in Miami, and now you are jumping on the Browns Bandwagon. The Browns have won nothing in years, that i can remember, and they haven't acquired any talent to do much better in the upcoming seasons.
They hired a Washed up Holgram who came in and fired everybody but the one who needed to be fired, Mileti. His new hires included a washed up quarterback, who had one of his worst years as a Pro last year. So you think they are going someplace? If they win three or four games they are lucky.
The White News Media has been on Lebron because they think like the Owner of the Cav's, that LeBron was a property of theirs, even though he was a "Free Agent". Lebron gave the Cav's the Option to bid on his services just like he gave all the other Teams, and Miami won, so the Cav's should move on.
Or did the Cav's Ownership expect Lebron to take less money to play in Cleveland. He took less in Salary Cap Money, but he got more in Endorsement Money, which might be the big money. There is also a rumor that Lebron is buying Pat Rileys $50M house in Coral Gables. I don't know if he's paying that much in Florida's depressed Housing Market or not. However in some places in florida Housing are going for 15-$.20 on the dollar. Plus the fact that LeBron just finished his house in Summit County, and some say that was a 5-$7M project.
Anyway, Lebron is gone, and Cleveland and it's Owner should not expect other Players to play for them for less money than they can get elsewhere. That's like giving away the future of themselves and their family. I don't think the owners do that.
You have to assume that Mr Forbes 10,000 number in a 150 square foot area is an "off the top of his head" estimate. For you to accept that as Fact, it's questionable as to who the Moron might be. However, does the 150sq include just sidewalk area, or does it also include the streets, or the land where all the buildings and Clubs sit?
Don't get caught up in the hype, Fast Food Firms are hurting from a bad economy just like everyone else. However the fact of the matter is that businesses have kept their wages supressed, but have allowed their prices to creep upward. Consequently, with fewer people working and making less money, there are less dollars chasing more goods and services from abroad that are not really dropping in price. You might find a few of these price games played here and there, but for the most parts, most people can't afford an Angus Burger at $4, when not too long ago they could get a similar Sandwich for $2 or so. So the Retailers haven't reduced their prices, but they have somewhat juggled their prices to give the appearance of a lesser price. However they will still have to chase fewer dollars to get their products sold.
So I expect a lot more small retailers to fail in the coming months and years, because individuals making good wages are not coming back. A good example is the new hires at GM (Green Economy) are being paid $14 per hour while those working along side them are paid 28-$30 per hour. Some people seem to think the economy is in a "Down Cycle", but I think it's more realistic to assume that our economic structure is experiences fundamental changes, and headed in a direction of a "Third World" Country where there is just the Rich and the Poor, but no middle class.
The Recent Wall Street Deregulation of the financial system that cause the most recent Crash of our Banks and the Stock Markets could resurface again if the same people who allowed the conditions to develop that caused the Crash end up taking political power again.
I Posted comment yesterday, but it didn't appear, does this think work consistently?
This appears to be more of a Political Disbursement than economic. $150,000 wouldn't be enough to do much of anything in the area of supporting a Business program. What Minority Businesses needs mostly from the State is the inclusion into their normal purchasing of their goods and services. The Governor have to devise ways to break up these old-boy networks where the Contracts keeps going to the same Business Firms year after year.
It's expected that most of the expertise will be among those that have been given all the Contracts over the years, but that is what has to e broken down. The Governor has to move people around to create diversity in all those Departments where goods and services are purchased to eliminate Purchasing Agents being too familiar with the Contractors. In some cases these individuals are even related. All that stuff has to be broken up, so to make a long story short, the $150,000 disbursements doesn't have anything to do with Minority Business, even if the Governor gave $150,000 to one minority Business it wouldn't mean nothing, what could he do with it, pay a couple of light bills, and then go looking again for places to sell his goods and services.
Is this Portman Guy trying to re-invent himself. He was the Trade Rep for the Bush Administration. Plus the fact he served in many capacities in the Federal Government for short periods of time as if he didn't fit in anywhere. He is the main reason most of our Jobs are in China now, he help to send them there. If he didn't he, as Trade Director didn't do anything to help.
These Republicans represent an unintelligent Base nof Voters who don't nknow that these are the people who put this Country in the position that it's in today, and the current Administrations are trying to get us out of this situation, and it will take some time.
As an African American Newspaper the Call N Post should be in the middle of this New Energy Technology, and how, and if African Americans are playing a part. What Training Programs are available, and what employment opportunities are currently available in this Business Environment. In a City where 50% of the Residents are African Americans, we have very little input on whats going on. It's always a bunch a "White Boys" deciding what everybody else is suppose to do, but wnen we end up with a high Crime Rate, excessive Poverty, and a 50% Unemployment Rate, one or two of these so called Leaders start looking at each other asking, what happened, like they care.
I think there are two programs involved in acquiring Urban Property for future development in Cuyahoga County. This might be the HUD Program, but I think there is also a Program that was imminating from the County Auditor Group where they were suppose to create open Spaces, and Industrial use properties, and Parks. But I don't think they had housing in their plan. I think their primary interest was to clean the Resident out and stop the recycling of the same low income individuals that were there before. If there is no economic activility created with the housing, the new housing will soon revert to what it was before, rapid depreciation.
The News Media jumped on Dan Gilbert's Bandwaggon when his open Letter critized LeBron's decision to leave, and they piled on Jesse Jackson when he made his point about Gilbert's Letter sounding like he was LeBron's Slavemaster.
However Rev Jackson was right, Gilbert disrespected the League's free Agency's Policy which allowed LeBron to do what he did. As the Commissioner indicated, LeBron and the other Players didn't violate any League Rules or anything, so Stern had to fine Gilbert $100K.
Gilbert lost it for a minute, thinking LeBron was his property. While all the time he was a free agent who did give the Cav's the opportunity to submit offers along with all the other teams that were interested., and I guess the Cav's offer wasn't the best offer.
In my personal opinion I think the Cav's were at a disadvantage in this process. Dan Gilbert is Wealthy, but I think he proved to be a lightweight when it can to matching up with what Riley and the Heat threw at him. I think there is much more to this deal than what appears now, and Gilbert couldn't have matched it anyway.
The first part is the outside endorsements where LeBron stopped and signed a batched of papers at the William Morris Agency in Conneticutt prior to going to Miami. LeBron keeps talking about his Agent, but the agency that has represented all three players since the Olympics is CAA which is a Subsidary of the Williams Morris Agency, if i'm not mistaken. Plus they say there is a deal pending on Riley's $49M Mansion in Coral Gables that LeBron is suppose to be moving into..
This wheeling dealing procedure has shed some new light on the so call "Salary Gap" set-up in the NBA, and how effective it really is in allowing teams to maintain a certain equality, while not having any knowledge or control of deals outside the Leagues jurisdiction. I think we will see major changes in the net "Collective Marketing" Agreement.
Michael Jordan also made a statement about LeBron Deal when he indicated that he was more concerned with defeating other players than joining them. However, Jordan has a person interest since he just bought the Charlotte Hornets with every penny he had. Now it's possibly that his investment will decline, because if the league doesn't change anything the system will go back to what it was before when the "Big Markets" will have the advantages to put together the best teams.
I found it kinda strange that a writer from an African American Newspaper didn't mention how much the African American Community, and it's people have benefitted from Teams with mostly members of their Race. The LeBron's and the other Players make big money, but most other African Americans can't even afford a Ticket to the Games.
African American earn very little of the money from Jersey's, Food, and other sales, but we are acting like we are the one's who are making all the money from LeBron being a Cav. I doubt if LeBron spends much of his Salary with African American Businesses, if any at all.
These High Profile Afrifcan American Athletes are not very significant to our Community, since their earnings benefits few Africans Americans. This Sports Activity is mostly relegated to the White and Well-to-do Community. Those who can afford the Tickets, and buy the other stuff. That includes few of us.
It's kinda silly that Minority Media are taking any Administration's Word about what they are doing for Minority Businesses when anybody can walk out on the street at any time and observe various Construction or Infrastructure Projects and see no Blacks. And when it comes to doing business with Minority Contracftors they are talking about foreigners who just came here a few years ago, and got themselves certified as Minority Business Enterprises. It seems as if many Asian Indians are transferring their Wealth to the U.S. and buying up many types of Business Enterprises, and creating many others. They buy small hotels and bring in all of their relatives. The Fed's historically have included these type of businesses as Minority Businesses, even though some principles aren't even U. S. Citizens. However, the average person don't think of them as such. Many of the H-1B employee's who got laid off during the economic downturn ended up creating businesses and got government contracts also, both State and federal.
I didn't make much sense to leave the GM in place, since he was most responsible for putting the team together that couldn't win in the Play-off's. However just appointing his assistant to replace him is an indication that Gilbert was just interested in running his own team. Now Gilbert is interested in hiring Izzo, but he want's to interview Byron Scott to act like he's wanted another Black Coach while he has supposely made a firm offer to Izzo. This move by the Cav's is similar to what the NFL does with the "Rooney Rule", where most teams now are making a mochery of that rule, and in the NFL they do it while having no intention of hiring a Black Coach. It hasn't reached this level in the NBA, as of yet. But they are reaching back in history to come up with some strange people to do their coaching, like Doug Collins,and Utah has held on to their relic about 20 years while not wining any title, but Black Coaches get Fired after two or three years with good records. I expect Fratillo(sp) to resurface somewhere again soon, since Jordan decided to keep Larry Brown, but maybe he had coached for most of the other Teams or owners, and nonew were interested.
Contrary to LeBron's Fan support, the "Sign N Trade" is a viable option for the Cav's if they are truly thinking of spending that kind of money on Izzo, a College Coach who probably knows little of the uniqueness of individuals players in the NBA, and I think thats critical for a Coach who fired the former Coach because he didn't win a title. It seems as if Gilbert would be thinking of hiring a Coach who could get him past where Brown left off.
Considering the fact that Izzo would be a "Novis" Coach in the NBA, he would take a couple of years to learn the players in the League, and to analize the coaching stype of the many coaches he will be competiting against.
Considering how the Cav's finished the last three years, with' LeBron, it's doubtful they would improve or get a Title the next year or two with him on the team anyway. Considering they wouldn't be in a position to add any new "quality" players to the Roster. A sign N Trade for two top starters, and one quality player coming off the bench could make they a contender. As I just said, dependng on LeBron alone doen't appear to be a road to a Title. They need a quality Point Guard who can run the Offence and penetrate. They need a "Bruser" who can score 15+ PPG and get 10 RPG, consistently. The Cavs are not tough enough on the "Block" to be a contender. They are not consistently aggressive, LeBron will not force himself inside to get his opponent in foul trouble, and possibly get the N-1.
The Cav's and the Lakers are similar, both teams are soft teams, they are not tough enough to win the tough games. Boston is not as talented as the Lakers, but they can "out tough" them, and they might beat LA for the title. Boston is just agressive, and they keep the pressure on, but they are old and less talented than most of their opponents. I remember in that Magic Series where Kevin pounded Howard on his Arm with his fist, two times, and the Ref only called a regular foul after the second hit. He should have been evicted from the game for hitting an opponent with a closed fist.
Few players would have attempted something like that, but Boston tries to intemidate their opponents in that manner. In that incedent an oppotent is suppose to be able to put his hand on you if the offensive player doesn't have the ball going to the basket, and Kevin didn't have the Ball headed to the Basket, he just decided to punch Howard because he didn't like the idea of Howard Measuring him like that, which is legal. The Cav's don't have a mentality like that, but you have to be tough and agressive to win a Championship.
Many observers believed that Brown didn't use his Players properly, and it was easy to get in his "Doghouse", and to the detriment of the team. It appeared as if he would put a player at the end of the bench based on something he did, or didn't do in a previous game, while not using the player to give the team a chance to win the current game. I don't understand that logic, other teams do it also, but they still have to pay the player, don't they? They didn't suspend him, so I don't understand what that means. They end up paying the player for not working.
However The Cav's biggest weakness was that it didn't have enough quality players to support LeBron, and that was a problem with the drafting and trading which was mostly the responsibility of the GM. Before they got Jamerson I don't think the GM acquired any player with a history of a 20ppg or 10rpg average to support LeBron's production.
All the Pundits often state that LeBron has to get others involved. That sound alright, but in the process he is delaying his production to the end of the game so his non-productive team-mates can be productive. So many of the Cav's game were won in the 4th quarter, no solid balanced agressive play over 4 quarters.
If the Team was productive in the first quarter, they usually falterd in the 2nd half, and in some cases they barely won. I predicted last year and this year that they wouldn't win a Championship, they are just not tough enough. They don't have enough toughness on the "Block", and some players can intimidate LeBron defensively, and make him shy away from going to the hole when it's necessary.
LeBron can't keep missing Jumpshots at crucial times in the game and allow his opponents to get easy transition buckets. LeBron will not force himself inside to try and get the Bucket, the N-1, and get his opponent in foul trouble. LeBron has to keep going inside, even if he don't get the call. He has to keep the pressure on them, but he doesn't, consistently.
He likes to drive the lane when it a one on one TV highlight thingy, but not when he should be trying to get the defenders hand caught in the rim while trying to block his shot. Or if the defender want's to take a charge, let him take a real charge, and if you accidentally land with those size 20's on his forehead, the defender won't be flopping too many times. LeBron has to stop playing like his opponents are the Toughguy. He has to let them know that they have to take some licks too. It ain't a one way street.
However, if you play soft, teams like Boston will beat you down. They also have the Ref's scared by complaining afterever call against them. This is in hope that the Ref will be scared to call all the fouls against them, and they will have the edge at the end. An older experienced team like Boston try to play mind games, and use intimidation to defeat their opponents.
Like last night, LA didn't fall for the intimidation. It was Kevin who ended up getting intimidated, and they limited his productivity. The so called Soft Player Gasol ended up being the intimidator on the Block, at least for game one last night, but it's a 7 game series, and LA has a history of having up and down games, so we will have to wait and see.
I'm not concerned with the racial profiling aspect of this Law, all i'm concerned with are the illegals who have been able to penetrate our Borders for many years, and contrary to what some say, we don't know who's coming into the Country at any given time.
All we know is that they are creating a strain on our System of Government that we are not able to manage. We have allowed these illegals to depress our wage scale, flood our Schools, Hospitals, and other Institutions, and the System can't handle it financially. Look what it has done for the Budget of California, and eventually it will bring the System down.
We have allowed Businesses to uses this "Cheap" Labor to destroy our way of life, and our ability to earn a quality wage. It was once said that they take Jobs that Americans wont do, well that's a Myth. They also drive Trucks, and operate heavy Construction Equipment. Many of these jobs Blacks have never been able to get, but now illegals can get them.
So now we have a lot of Blacks running around as though they just got off the "Turnip Truck". However Black Politicians fail to anything about Black unemployment being twice that of Whites, but they are interested in illegal who can't vote, yet. But I guess they expect to get the Legal Vote of their relatives. These Black Leaders are so concerned with upholding the illegals, their interest, and their kind, but none of then even give Blacks the time of day. Nor do Latino Busdinesses hire Blacks, and none shop in Bladk Businesses.
In some California Cities these Lation's are trying to run Blacks out of Town, and make it a Latino City. But just like Blacks did Auturo(sp) Davis a few days ago in Alabama who was running for Governor, Blacks voted against him and supported the "White Boy". If Obama don't watch it, he could end up the same way since he's already going downhill. Your support has to be with what brung you.
I'm kinda confused about the location of the Garden, I was under the impression that East Blvd in that area (formerly Liberty Blvd) was renamed Martin Luther King Blvd. Plus the fact that St Clair Avenue runs East and West, and East Blvd runs north and south, so how can the Garden be between the two? They run different ways.
I don't know where the Garden is located, but the directions should state between St Clair and Wade Park on the West side of MLK, or between Wade Park and Superior, or between Wade Park and E. 105th, or between E. 105th and Chester. You should also indicate what highly visable Garden it's also near. Just an off handed suggestion.
I don't understand why this newer software has to make it more difficult for someone to post. It seems to me that you would want someone to post comments or visit your site, and with as little difficulty as possible.
When I sign-in, the dialog box don't indifcate submit, or nothing, I have to hit the return key, and the internet explorer box pops up. Then it goes back to the top of the page rather than to the Comment Box I came from.
After the comment there is no link or box indicating submit or send. I have to move my pointer around until if notice a change (an arrow), but no message. There seem to be two of these change areas near the bottom right outside the comment box, but none offer any message to indicate what they are. So I click on one and it brings up my comment review, but if I click on the other it will post the comment without a review. It my understanding that this is a security feature to keep a non-human from posting a comment, but for a lot of reasons, many would not even bother to post a comment if they have to be bothered with that type if agony.


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censured!!! oooh. was devastating to charlie rangel.
shop rite would make a killing here.
i've been to both james st. and pond st. locations many times. it seemed the pond street store was just as busy. they have the room to expand at pond street if they really wanted. they wanna be upscale and that locale doesn't fit with the agenda. they coulda tried harder to make it more successful. sorry 10.99 per pound steaks aint gonna make it there.
why are they so interested in who's who? not too far away from chips.
how bout we invest in imbedded cameras for every police arrest at the scene? this would ensure proper procedeures.
i'm sure this will affect change within the syracuse establishment.
hmmm, 17 million per year for acc teams? follow the money as the old addage says.
i've seen them give 15 year old murderers youthful offender status. are you kidding me here? he's 15!!!! do we expect the kid to understand the legal system?
i love how people think this is just a sports infraction, but if i did this during a pickup game i'd have been put in cuffs!!!!! it's flat out assault and we got it on camera! when is this type of behavior gonna become a criminal act. until it does this type of behavior will continue.
and you believe this? my premiums have went up 100 percent since obama took office! so we save 20 percent off the 100 and thats a savings?
she's more likeable than the cromagnon danny bot i mean boy.
he still hasn't apologized for shooting that guy in the face.
norovirus is caused by human feces! did someone not wear gloves and forget to wash their hands before mixing the salads? totally disgusting!
not surprised with the ignorance here with the replies. these are the same people who voted for fitzy!
just win baby! is that right? well, obviously your a homer, cause what i see is a master manipulator caught with his pants down. open your eyes!
ok, call in sick? you're fired! trust me it's true.
ugh now we get that smug cromagnon dan maffei back. thanks.
i've lived in syracuse for 10+ years (from nyc), and all the pizza is terrible around here. no place compares to nyc. not even close!
lol are you that much of a mook! we got the keystone cops running this outfit and did you see fitzy's popsicle suit? get ur head outta u know where!!!
after reading the comments , it's pretty obvious there is no chance of a fair trial here in syracuse.


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Blue or green stains are a sign of copper: It may have entered your water supply; or, you might have copper pipes that are being corroded. Start by having your water tested for copper; also, check its pH, total dissolved solids content, and oxygen content. Most ordinary water softeners will remove copper, through the ion exchange process. However, if corrosive water is the cause of the problem, you'll need to address that issue, or else the copper will reappear in your water supply. Water with a low pH is considered acid, or corrosive: it attacks metals like copper, causing it to leach into the water. When your water's pH is between five and seven, you can raise it by running the water through calcium carbonate. If the pH is less than five, chemicals must be added. Sometimes, the corrosion may be caused by excess oxygen. To solve this type of problem, a coating substance may be introduced into the pipes, or the water may be aerated, to reduce the amount of oxygen. For more information on preventing blue and green water stains, contact a water conditioning company in your area.
Blue and green water stains
Blue and green water stains
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Stock Market & Financial Investment News
News Breaks
January 17, 2014
Concerns on Perrigo overdone, says RBC Capital
RBC Capital reported that investors have become concerned about Perrigo due to a later start to the flu season, early mixed channel commentary and a lack of P&L clarity. But the firm thinks the concerns are overdone, as it believes that flu has less of an impact on Perrigo's business now than in the past, while the company has several unrelated upcoming positive catalysts. The firm keeps a Top Pick rating on the stock.
News For PRGO From The Last 14 Days
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August 4, 2015
Notable companies reporting before tomorrow's open
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July 31, 2015
Stocks end week higher in U.S. despite selloff in China
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July 29, 2015
Mylan's Perrigo acquisition receives clearance from European Commission
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July 28, 2015
Mylan expected to launch tender offer for Perrigo in early September, CNBC says
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Mylan price target lowered to $54 from $82 at BMO Capital
BMO Capital cut its price target on Mylan (MYL) after Teva (TEVA) announced that it was abandoning its bid to buy the company. The firm expects Mylan's stock to continue to face selling pressure in the wake of the news. The firm says that investors will wonder if Mylan can buy Perrigo (PRGO) following the decline in its share price. BMO believes that Perrigo "will put up a strong fight," and it does not think that the deal would be favorable for Mylan in any event. BMO keeps a Market Perform rating on Mylan.
Mylan price target lowered to $54 from $82 at BMO Capital
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July 27, 2015
On The Fly: Top stock stories for Monday
Stocks began the session deep in negative territory, with weakness attributed to the Chinese market suffering its worst one day loss in over eight years. The U.S. indexes remained in the negatives throughout the day as traders prepare for one of the heaviest weeks for this earnings season. ECONOMIC EVENTS: In the U.S., durable goods orders advanced 3.4% in June versus expectations for a 3.2% increase. Excluding transportation items, the core reading was up 0.8% against estimates for a 0.5% gain. In China, the Shanghai composite index fell 8.5% and the Shenzhen composite dropped 7%, with the moves generally attributed to concerns over growth and fears that the government may pull its market support. Note that Dow Jones quoted the country's top securities regulator this morning as saying China plans to increase stock purchases by the state. COMPANY NEWS: Shares of Teva (TEVA) jumped $10.15, or 16.41%, to $72.07 after the generic drugmaker dropped its pursuit of Mylan (MYL), opting instead to acquire Allergan's (AGN) global generic pharmaceuticals business for $40.5B. Allergan shares rose 6.09% for the session, and Mylan fell 14.51% to $56.37 while reiterating its commitment to pursue Perrigo (PRGO), whose shares gained 3.81% to $193.60. MAJOR MOVERS: Among the notable gainers was Wabtec (WAB), which rose $6.59, or 7.21%, to $97.93 after agreeing to buy Faiveley Transport for roughly $1.8B, noting that it expects EPS accretion in 2016. In other M&A news, Magnetek (MAG) finished the session up $17.27, or 53.55%, to $49.52 after Columbus McKinnon (CMCO) agreed to acquire the company for $50 per share, while Beacon Roofing Supply (BECN) jumped $2.62, or 8.71%%, to $32.70 after agreeing to buy Roofing Supply Group at a transaction value of about $1.1B. Also higher were shares of Xueda Education (XUE), which surged 50.63% after Xiamen Insight Investment announced a deal to purchase the company for $5.50 per American Depository Share. Xueda's positive move came in stark contrast to numerous Chinese stocks traded in New York, with Baidu (BIDU) slipping 4.16% and Alibaba (BABA) losing 2.01% after China's Shanghai composite index plunged overnight. Also lower was McGraw Hill Financial (MHFI), declining $6.01, or 5.69%, to $99.59 after agreeing to acquire SNL Financial for roughly $2.225B in cash. Additionally, GrubHub (GRUB) lost 8.37% to $30.99 following a downgrade from Cowen citing competitive concerns and market saturation. INDEXES: The Dow fell 127.94, or 0.73%, to 17,440.59, the Nasdaq lost 48.85, or 0.96%, to 5,039.78, and the S&P 500 declined 12.01, or 0.58%, to 2,067.64.
On The Fly: Top stock stories at midday
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On The Fly: Pre-market Movers
HIGHER: Magnetek (MAG), up 53.5% after Columbus McKinnon (CMCO) agrees to acquire the company... Xueda Education (XUE), up 40.6% after merging with Xiamen Insight Investment... Box (BOX), up 4.6% after being upgraded to Overweight from Sector Weight at Pacific Crest... Goodrich Petroleum (GDP), up 6.4% after announcing sale of proved reserves and a portion of Eagle Ford leasehold. NOTABLE: Teva Pharmaceutical (TEVA), up 10.7% after acquiring Allergan Generics... Allergan (AGN) is up 6.3%... Mylan (MYL), down 14% after Teva withdraws proposal to acquire the company... Perrigo (PRGO), up 3% after Teva withdraws proposal to acquire Mylan. DOWN AFTER EARNINGS: Sohu.com (SOHU), down 6%... Changyou.com (CYOU), down 10.1%. ALSO LOWER: Bellerophon (BLPH) down 63% after announcing results of BCM clinical trial... Terex (TEX), down 4% after being downgraded to Sell from Neutral at Goldman... Ultragenyx Pharmaceutical (RARE), down 3.5% after being downgraded to Equal Weight from Overweight at Morgan Stanley...
July 26, 2015
Media reports say Teva to buy Allergan unit as it looks beyond Mylan
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July 24, 2015
Paulson may play key role in Teva-Mylan-Perrigo drama, CTFN says
John Paulson's hedge fund, Paulson & Co., has upped its stake in Mylan (MYL) to 4.65%, which is below the threshold that would compel it to disclose its plans to the U.S. SEC but high enough for it to obtain standing before the Dutch Enterprise Chamber, which would hear any legal challenge to the "stichting" maneuver the company is employing to avoid a takeover by Teva (TEVA), said CTFN. The takeover fight is most likely headed for court in Amsterdam after Mylan's shareholder foundation exercised an option to acquire shares and Paulson's involvement is noteworthy since he teamed with Centaurus Capital in 2007 to thwart a stichting ploy used by Stork, the report noted.
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July 23, 2015
Mylan, Teva lower after Stitching looks to thwart hostile deal
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Mylan foundation says shareholders at risk of Teva takeover
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July 22, 2015
Abbott CEO says supportive of Mylan pursuit of Perrigo
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Perrigo agrees to acquire Yokebe
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Gambling in 2012 - Part II
Gambling Law
As is often the case with gambling and online gambling law, in 2012 a lot of talking was done but not that much action was taken.
Just so that you could try and stay on top of the situation, we gave you a quick run down of gambling policy in Britain complete with each party views the industry and the legislative issues around it. That article was actually considerably more complex than it sounds given most gambling companies remained sceptical. William Hill even went as far to take the government to court over their plans for a point of consumption tax.
Slightly further afield, there have been even more suggestions put forward as to how to regulate online gambling throughout the whole of Europe. As is often the case, so far nothing has been decided.
Gambling Award Winners
A month rarely goes by without some sort of award being handed out to one or many online casino operators. However, 2012 got off to a bit of an unusual start on this front as bet365 chief Denise Coates was named in the Queen's New Year's Honours List.
That wasn't the only recognition going the way of the Stoke-based online casino operator either. In April bet365 were named in Investec's Hot 100 list where they received a special mention for one of the fastest growing companies in the UK.
But it wasn't just bet365 tasting success this year. 32Red was named the Best Online Casino yet again by Casinomeister – meaning that it's now won the award eleven times.
Betfair and Ladbrokes will also have been pleased with their year's work for the most part. Back in January Experian Hitwise listed the most popular casino websites with 888, William Hill, Betfair and Ladbrokes all included in the list.
Microgaming and Playtech also continued their dominance of the online casino market with Microgaming picking up a Reader's Choice Award in February while title="Multi-Award win for Playtech">Playtech tasted considerable success at the eGR B2B awards.
The Biggest Jackpots of 2012
Beach Life Slot
Big jackpots often hit the headlines and 2012 saw some of the biggest. While the biggest ever online progressive jackpot win, won last year, wasn't topped in 2012, we did witness the largest ever UK jackpot win which came on the Playtech Beach Life slot.
Also, the folks over at PartyCasino have been getting pretty excited about their The Big One jackpot. It's at its biggest ever and has been for some time so hopefully the big win will come soon in 2013.
Elsewhere, Playtech were breaking new ground with the launch of their second multiplayer progressive jackpot game while even Ant and Dec were getting in on the act by handing out a massive prize on the Red or Black television show.
Mobile casinos have even started to get in on the act with William Hill handing out more than £100,000 to a slots winner while loyalty clearly does pay off as a 32Red customer of nine years won big in October.
Casino Online Exclusives
At Casino Online we always like to get the scoop on the latest events were possible so this year we spoke to some of the most knowledgeable people in gambling.
It all started off with our Casinomeister interview with the man himself Bryan Bailey. Brian revealed his thoughts on what he thinks makes 32Red so good, Betfair disappointing and just about everything else in between.
Then, as you do, we went to check out Soccer AM presenter Max Rushden knock down a model of the Houses of Parliament that was made out of cards. But that wasn't before speaking to Bryan Berg, also known as the Cardstacker, about all of the weird and wonderful projects he's worked on.
Finally we spoke to renowned gambling law expert Professor I Nelson Rose who told us all about the chances of online casinos becoming legal in the US. As the focus of online gambling law in the US has been poker, this threw up some really interesting points.


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So, who wants to play? Here I am last week on my 40th birthday - My dog Mishka is next to me - sorry for the glowing eyes - the camera does that sometimes.
Go for it!!! It will grow back...besides the difference between loving & hating a new haircut is sometimes because the client chickens out & let's only go half way. It loses the drama! Much like decor- something half done fizzles out. Besides your present cut ( in pic) is short already the blonde is short in the inside lines (shorter layers) it won't be too shocking- DO IT!! It will look great on you;)
love the blonde cut & the red colour...do you know what colour line your stylist works with? Is he/she good with texturizing? A razor cut can get you good & tousled without too much goop.
From what I understand, Homesense is the equvalent to our winners.
Oh come now guys.... get your pics up here!!! Come on... don't be shy!!! :-)
like Michy, I too imagined you like that- nice to meetchya!!
Hmmm... that pic won't show up the right size. It's skewing... I'll post another.
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