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Former Names Tnfr2 (Changed: 15-DEC-04 ) Type Congenic; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/6 Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2) Donating Investigator Dr. Jacques Peschon, Amgen
Mice homozygous for a Tnfrsf1btm1Imx targeted mutation (formerly Tnfr2tm1Imx, p75 deficient) are viable and fertile. T cells from homozygous mutant mice display defects in activation induced cell death in vitro and dramatically elevated levels of circulating Tnf following systemic challenge with LPS. Pulmonary neutrophil influx is exacerbated in p75 deficient mice in a model of hypersensitivity pneumonitis.
The p75 mutation was made by homologous recombination in the 129/SvEv derived AB1 ES cell line using a gene replacement vector in which a 1 kb Kas1-BamH1 fragment was replaced with a PGKneo cassette. The resulting null mutation results in a deletion of amino acids 3 - 26. This strain was generated on a 129/SvEv background and is currently at N5 on a C57BL/6 background.
|Considerations for Choosing Controls
Strains carrying Tnfrsf1btm1Imx allele
003243 B6.129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J 024314 NOD.Cg-Tnfrsf1btm1Imx Tnfrsf1atm1Imx/JView Strains carrying Tnfrsf1btm1Imx (2 strains)Strains carrying other alleles of Tnfrsf1b
002620 B6.129S2-Tnfrsf1btm1Mwm/JView Strains carrying other alleles of Tnfrsf1b (1 strain)
View Related Disease (OMIM) TermsRelated Disease (OMIM) Terms provided by MGI
- No similarity to the expected human disease phenotype was found. One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of these genes, but the phenotype did not resemble the disease.Hyperlipidemia, Familial Combined; FCHL
Hypertension, Essential
View Mammalian Phenotype TermsMammalian Phenotype Terms provided by MGIassigned by genotype
- skeleton phenotype
- *normal* skeleton phenotype
- no increase in bone mineral density (MGI Ref ID J:135519)
- respiratory system phenotype
- *normal* respiratory system phenotype
- display a rapid increase in peak inspiratory pressure when exposed to high stretch ventilation, as is seen in controls (MGI Ref ID J:143836)
- abnormal lung compliance (MGI Ref ID J:143836)
- homeostasis/metabolism phenotype
- abnormal blood gas level
- cardiovascular system phenotype
- decreased systemic arterial blood pressure
- drops below 45mm Hg by 70 minutes of high stretch ventilation whereas controls require 90 minutes (MGI Ref ID J:143836)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.
Tnfrsf1btm1Imx/Tnfrsf1btm1Imxinvolves: 129S7/SvEvBrd * C57BL/6
- immune system phenotype
- abnormal microglial cell morphology
- numbers of microglial cells significantly increased relative to controls after epileptic stimulation (MGI Ref ID J:112713)
- increased circulating tumor necrosis factor level
- two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered (MGI Ref ID J:45147)
- increased inflammatory response
- increased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control (MGI Ref ID J:45147)
- lung inflammation
- increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid (MGI Ref ID J:120174)
- homeostasis/metabolism phenotype
- *normal* homeostasis/metabolism phenotype
- normal recovery after superficial injury causes an increased trans-epidermal water loss (MGI Ref ID J:59056)
- decreased susceptibility to dopaminergic neuron neurotoxicity
- 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%) (MGI Ref ID J:78637)
- increased circulating tumor necrosis factor level
- two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered (MGI Ref ID J:45147)
- nervous system phenotype
- abnormal glutamate-mediated receptor currents
- increased glutamate currents (MGI Ref ID J:152590)
- abnormal microglial cell morphology
- numbers of microglial cells significantly increased relative to controls after epileptic stimulation (MGI Ref ID J:112713)
- decreased susceptibility to dopaminergic neuron neurotoxicity
- 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%) (MGI Ref ID J:78637)
- tumorigenesis
- increased skin papilloma incidence
- development after DMPA/TPA treatment is reduced (MGI Ref ID J:89088)
- respiratory system phenotype
- lung inflammation
- increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid (MGI Ref ID J:120174)
- hematopoietic system phenotype
- abnormal microglial cell morphology
- numbers of microglial cells significantly increased relative to controls after epileptic stimulation (MGI Ref ID J:112713)
- integument phenotype
- increased skin papilloma incidence
- development after DMPA/TPA treatment is reduced (MGI Ref ID J:89088)
- cellular phenotype
- decreased susceptibility to dopaminergic neuron neurotoxicity
- 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%) (MGI Ref ID J:78637)View Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Tnfrsf1btm1Imx related
Apoptosis Research
Death Receptors
Cancer Research
Growth Factors/Receptors/Cytokines
Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
|Allele Symbol
|Allele Name
|targeted mutation 1, Immunex Research and Development Corporation
|Allele Type
|Targeted (Null/Knockout)
|Common Name(s)
|TNFR2-; TNFRII-; TNFbeta ko; Tnfrsf1btm1Imx; p75 KO; p75-;
|Mutation Made By
|Dr. Jacques Peschon, Amgen
|Strain of Origin
|ES Cell Line Name
|ES Cell Line Strain
|Gene Symbol and Name
|Tnfrsf1b, tumor necrosis factor receptor superfamily, member 1b
|Gene Common Name(s)
|CD120b; TBPII; TNF-R-II; TNF-R2; TNF-R75; TNF-alphaR2; TNFBR; TNFR1B; TNFR2; TNFR80; TNFRII; TNFalpha-R2; Tnfr-1; Tnfr2; p75; p75 TNFR; p75TNFR; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2;
|Molecular Note
|A PGK-neomycin resistance cassette replaced 1kb of sequence encoding amino acids 3 - 26. Lack of gene product was shown functionally. [MGI Ref ID J:45147]
Genotyping ProtocolsTnfrsf1btm1Imx, Standard PCR
Helpful LinksGenotyping resources and troubleshooting
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Berta T; Park CK; Xu ZZ; Xie RG; Liu T; Lu N; Liu YC; Ji RR. 2014. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion. J Clin Invest 124(3):1173-86. [PubMed: 24531553] [MGI Ref ID J:209726]
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Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508] [MGI Ref ID J:90518]
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Brito BE; O'Rourke LM; Pan Y; Anglin J; Planck SR; Rosenbaum JT. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9. [PubMed: 10509653] [MGI Ref ID J:115094]
Broide DH; Stachnick G; Castaneda D; Nayar J; Sriramarao P. 2001. Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice. Am J Respir Cell Mol Biol 24(3):304-11. [PubMed: 11245629] [MGI Ref ID J:114289]
Bruce AJ; Boling W; Kindy MS; Peschon J; Kraemer PJ; Carpenter MK; Holtsberg FW; Mattson MP. 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2(7):788-94. [PubMed: 8673925] [MGI Ref ID J:33864]
Cambien B; Bergmeier W; Saffaripour S; Mitchell HA; Wagner DD. 2003. Antithrombotic activity of TNF-alpha. J Clin Invest 112(10):1589-96. [PubMed: 14617760] [MGI Ref ID J:117987]
Cataisson C; Pearson AJ; Torgerson S; Nedospasov SA; Yuspa SH. 2005. Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo. J Immunol 174(3):1686-92. [PubMed: 15661932] [MGI Ref ID J:96402]
Chan FK; Shisler J; Bixby JG; Felices M; Zheng L; Appel M; Orenstein J; Moss B; Lenardo MJ. 2003. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J Biol Chem 278(51):51613-21. [PubMed: 14532286] [MGI Ref ID J:89973]
Chandrasekharan UM; Siemionow M; Unsal M; Yang L; Poptic E; Bohn J; Ozer K; Zhou Z; Howe PH; Penn M; DiCorleto PE. 2007. Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo. Blood 109(5):1938-44. [PubMed: 17068152] [MGI Ref ID J:145363]
Chen CP; Hertzberg M; Jiang Y; Graves DT. 1999. Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155(6):2145-52. [PubMed: 10595943] [MGI Ref ID J:58851]
Chen MC; Mudge CS; Klumpp DJ. 2006. Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis. Am J Physiol Renal Physiol 291(4):F741-9. [PubMed: 16622179] [MGI Ref ID J:144913]
Chen SE; Gerken E; Zhang Y; Zhan M; Mohan RK; Li AS; Reid MB; Li YP. 2005. Role of TNF-{alpha} signaling in regeneration of cardiotoxin-injured muscle. Am J Physiol Cell Physiol 289(5):C1179-87. [PubMed: 16079187] [MGI Ref ID J:104990]
Chen SE; Jin B; Li YP. 2007. TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK. Am J Physiol Cell Physiol 292(5):C1660-71. [PubMed: 17151142] [MGI Ref ID J:125884]
Chopra M; Lang I; Salzmann S; Pachel C; Kraus S; Bauerlein CA; Brede C; Garrote AL; Mattenheimer K; Ritz M; Schwinn S; Graf C; Schafer V; Frantz S; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS One 8(9):e75737. [PubMed: 24098720] [MGI Ref ID J:207733]
Chopra M; Riedel SS; Biehl M; Krieger S; von Krosigk V; Bauerlein CA; Brede C; Jordan Garrote AL; Kraus S; Schafer V; Ritz M; Mattenheimer K; Degla A; Mottok A; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis. Carcinogenesis 34(6):1296-303. [PubMed: 23385062] [MGI Ref ID J:198326]
Churg A; Zhou S; Wang X; Wang R; Wright JL. 2009. The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. Am J Respir Cell Mol Biol 40(4):482-90. [PubMed: 18931327] [MGI Ref ID J:159269]
Cliffe LJ; Potten CS; Booth CE; Grencis RK. 2007. An increase in epithelial cell apoptosis is associated with chronic intestinal nematode infection. Infect Immun 75(4):1556-64. [PubMed: 17242061] [MGI Ref ID J:119507]
Cowley SC; Hamilton E; Frelinger JA; Su J; Forman J; Elkins KL. 2005. CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202(2):309-19. [PubMed: 16027239] [MGI Ref ID J:100513]
Cowley SC; Sedgwick JD; Elkins KL. 2007. Differential requirements by CD4+ and CD8+ T cells for soluble and membrane TNF in control of Francisella tularensis live vaccine strain intramacrophage growth. J Immunol 179(11):7709-19. [PubMed: 18025217] [MGI Ref ID J:155094]
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Cusson N; Oikemus S; Kilpatrick ED; Cunningham L; Kelliher M. 2002. The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death. J Exp Med 196(1):15-26. [PubMed: 12093867] [MGI Ref ID J:120699]
Deepe GS Jr; Buesing WR. 2012. Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection. J Immunol 188(1):334-44. [PubMed: 22102723] [MGI Ref ID J:180361]
Di Giuseppe M; Gambelli F; Hoyle GW; Lungarella G; Studer SM; Richards T; Yousem S; McCurry K; Dauber J; Kaminski N; Leikauf G; Ortiz LA. 2009. Systemic inhibition of NF-kappaB activation protects from silicosis. PLoS One 4(5):e5689. [PubMed: 19479048] [MGI Ref ID J:149316]
Eaton LH; Roberts RA; Kimber I; Dearman RJ; Metryka A. 2015. Skin sensitization induced Langerhans' cell mobilization: variable requirements for tumour necrosis factor-alpha. Immunology 144(1):139-48. [PubMed: 25039377] [MGI Ref ID J:220130]
Edelblum KL; Goettel JA; Koyama T; McElroy SJ; Yan F; Polk DB. 2008. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J Biol Chem 283(43):29485-94. [PubMed: 18713739] [MGI Ref ID J:142557]
El-Hayek JM; Rogers TE; Brown GR. 2005. The role of TNF in hepatic histopathological manifestations and hepatic CD8+ T cell alloresponses in murine MHC class I disparate GVHD. J Leukoc Biol 78(4):1001-7. [PubMed: 16081594] [MGI Ref ID J:101534]
Elizur A; Adair-Kirk TL; Kelley DG; Griffin GL; Demello DE; Senior RM. 2008. Tumor necrosis factor-alpha from macrophages enhances LPS-induced clara cell expression of keratinocyte-derived chemokine. Am J Respir Cell Mol Biol 38(1):8-15. [PubMed: 17673686] [MGI Ref ID J:143000]
Feliciani C; Toto P; Amerio P; Pour SM; Coscione G; Shivji G; Wang B; Sauder DN. 2000. In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis. J Invest Dermatol 114(1):71-7. [PubMed: 10620118] [MGI Ref ID J:127060]
Feng Y; Teitelbaum DH. 2012. Epidermal growth factor/TNF-alpha transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 302(2):G236-49. [PubMed: 22075779] [MGI Ref ID J:183319]
Feng Y; Teitelbaum DH. 2013. Tumour necrosis factor--induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition. J Physiol 591(Pt 15):3709-23. [PubMed: 23753529] [MGI Ref ID J:212137]
Fenger C; Drojdahl N; Wirenfeldt M; Sylvest L; Jorgensen OS; Meldgaard M; Lambertsen KL; Finsen B. 2006. Tumor necrosis factor and its p55 and p75 receptors are not required for axonal lesion-induced microgliosis in mouse fascia dentata. Glia 54(6):591-605. [PubMed: 16927297] [MGI Ref ID J:156117]
Finsterbusch M; Voisin MB; Beyrau M; Williams TJ; Nourshargh S. 2014. Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF. J Exp Med 211(7):1307-14. [PubMed: 24913232] [MGI Ref ID J:214447]
Flaherty MP; Guo Y; Tiwari S; Rezazadeh A; Hunt G; Sanganalmath SK; Tang XL; Bolli R; Dawn B. 2008. The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning. J Mol Cell Cardiol 45(6):735-41. [PubMed: 18824172] [MGI Ref ID J:143321]
Fromm PD; Kling J; Mack M; Sedgwick JD; Korner H. 2012. Loss of TNF signaling facilitates the development of a novel Ly-6C(low) macrophage population permissive for Leishmania major infection. J Immunol 188(12):6258-66. [PubMed: 22615203] [MGI Ref ID J:188958]
Fu Y; Xie C; Chen J; Zhu J; Zhou H; Thomas J; Zhou XJ; Mohan C. 2006. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol 176(1):632-9. [PubMed: 16365459] [MGI Ref ID J:126245]
Fujii T; Kitaura H; Kimura K; Hakami ZW; Takano-Yamamoto T. 2012. IL-4 inhibits TNF-alpha-mediated osteoclast formation by inhibition of RANKL expression in TNF-alpha-activated stromal cells and direct inhibition of TNF-alpha-activated osteoclast precursors via a T-cell-independent mechanism in vivo. Bone 51(4):771-80. [PubMed: 22776139] [MGI Ref ID J:192396]
Geis C; Graulich M; Wissmann A; Hagenacker T; Thomale J; Sommer C; Schafers M. 2010. Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain. Neuroscience 169(1):463-74. [PubMed: 20417692] [MGI Ref ID J:165239]
Gerstenfeld LC; Cho TJ; Kon T; Aizawa T; Cruceta J; Graves BD; Einhorn TA. 2001. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs 169(3):285-94. [PubMed: 11455125] [MGI Ref ID J:70467]
Gerstenfeld LC; Cho TJ; Kon T; Aizawa T; Tsay A; Fitch J; Barnes GL; Graves DT; Einhorn TA. 2003. Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption. J Bone Miner Res 18(9):1584-92. [PubMed: 12968667] [MGI Ref ID J:111507]
Goluszko E; Deng C; Poussin MA; Christadoss P. 2002. Tumor necrosis factor receptor p55 and p75 deficiency protects mice from developing experimental autoimmune myasthenia gravis. J Neuroimmunol 122(1-2):85-93. [PubMed: 11777546] [MGI Ref ID J:102961]
Goretsky T; Dirisina R; Sinh P; Mittal N; Managlia E; Williams DB; Posca D; Ryu H; Katzman RB; Barrett TA. 2012. p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD. Am J Pathol 181(4):1306-15. [PubMed: 22863952] [MGI Ref ID J:188612]
Grdina DJ; Murley JS; Miller RC; Mauceri HJ; Sutton HG; Li JJ; Woloschak GE; Weichselbaum RR. 2013. A survivin-associated adaptive response in radiation therapy. Cancer Res 73(14):4418-28. [PubMed: 23651635] [MGI Ref ID J:199011]
Guevara Patino JA; Ivanov VN; Lacy E; Elkon KB; Marino MW; Nikolic-Zugic J. 2000. TNF-alpha is the critical mediator of the cyclic AMP-induced apoptosis of CD8+4+ double-positive thymocytes. J Immunol 164(4):1689-94. [PubMed: 10657611] [MGI Ref ID J:60398]
Guma M; Stepniak D; Shaked H; Spehlmann ME; Shenouda S; Cheroutre H; Vicente-Suarez I; Eckmann L; Kagnoff MF; Karin M. 2011. Constitutive intestinal NF-kappaB does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med 208(9):1889-900. [PubMed: 21825016] [MGI Ref ID J:177595]
Guo G; Morrissey J; McCracken R; Tolley T; Liapis H; Klahr S. 2001. Contributions of angiotensin II and tumor necrosis factor-alpha to the development of renal fibrosis. Am J Physiol Renal Physiol 280(5):F777-85. [PubMed: 11292619] [MGI Ref ID J:69294]
Harrison-Findik DD; Klein E; Evans J; Gollan J. 2009. Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-{alpha} signaling. Am J Physiol Gastrointest Liver Physiol 296(1):G112-8. [PubMed: 19008338] [MGI Ref ID J:143085]
He S; Liang Y; Shao F; Wang X. 2011. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A 108(50):20054-9. [PubMed: 22123964] [MGI Ref ID J:180434]
Hill GR; Teshima T; Rebel VI; Krijanovski OI; Cooke KR; Brinson YS; Ferrara JL. 2000. The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity. J Immunol 164(2):656-63. [PubMed: 10623807] [MGI Ref ID J:59298]
Huang L; Zhang R; Wu J; Chen J; Grosjean F; Satlin LH; Klein JD; Sands JM; Striker GE; Tan J; Zheng F. 2011. Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-alpha and its receptor 1. Kidney Int 79(6):613-23. [PubMed: 21150875] [MGI Ref ID J:186880]
Iizuka K; Chaplin DD; Wang Y; Wu Q; Pegg LE; Yokoyama WM; Fu YX. 1999. Requirement for membrane lymphotoxin in natural killer cell development. Proc Natl Acad Sci U S A 96(11):6336-40. [PubMed: 10339588] [MGI Ref ID J:55470]
Ilg RC; Davies MH; Powers MR. 2005. Altered retinal neovascularization in TNF receptor-deficient mice. Curr Eye Res 30(11):1003-13. [PubMed: 16282134] [MGI Ref ID J:104652]
Iosif RE; Ekdahl CT; Ahlenius H; Pronk CJ; Bonde S; Kokaia Z; Jacobsen SE; Lindvall O. 2006. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci 26(38):9703-12. [PubMed: 16988041] [MGI Ref ID J:112713]
Ismail N; Stevenson HL; Walker DH. 2006. Role of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: increased resistance of TNF receptor p55- and p75-deficient mice to fatal ehrlichial infection. Infect Immun 74(3):1846-56. [PubMed: 16495559] [MGI Ref ID J:107384]
Jensen JM; Schutze S; Forl M; Kronke M; Proksch E. 1999. Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. J Clin Invest 104(12):1761-70. [PubMed: 10606630] [MGI Ref ID J:59056]
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Animal Health ReportsProduction of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
|Pricing for USA, Canada and Mexico shipping destinations
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2625.00
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Frozen Products
Price (US dollars $) Frozen Embryo $1725.00
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
|Pricing for International shipping destinations
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3412.50
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Frozen Products
Price (US dollars $) Frozen Embryo $2242.50
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
|Considerations for Choosing Controls
|Control Pricing Information for Genetically Engineered Mutant Strains.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
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The foregoing represents the General Terms and Conditions applicable to JACKSON's MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


text:
|By Kian Terani | November 11, 2012 | Comments
TNA Television Championship: Samoa Joe (c) vs. Magnus
The ref holds the belt up and the bell rings and they waste no time exchanging strikes. The action goes outside and Joe hits punches to the face and sends Magnus into the steel steps. Joe sends Magnus back in to "Joe" chants. Joe hits shots in the corner and kicks and a flying knee to a seated Magnus and gets 2. Joe ducks a clothesline and hits a flying knee to Magnus and takes him down. Magnus comes off the ropes with a clothesline but doesn't immediately capitalize. Magnus sends Joe in and hits his own knee to the gut.
Joe hits an Enzuigiri in the corner and Magnus rolls out. Joe grabs a chair and throws it at the head of a charging Joe. Magnus takes over in the ring. Magnus drops a knee for only 1. Magnus looks frustrated. Joe catches Magnus off the top with an inverted Atomic Drop and hits a snap powerslam for 2. Magnus goes for a leg scissors but Joe drops him in a powerbomb and applies the STF. Magnus reaches the ropes and applies an armbar to Joe. The crowd chants for Joe as the ref checks him for a submission. Joe counters into a cover and gets a near-fall. Joe hits another Enzuigiri and puts Magnus up top in the corner. Magnus fights him off and goes to the apron for a knee to the chest of Joe. Magnus goes up top and hits a nice elbow drop for 2.
Joe connects with strikes to the head and rushes in off the ropes but Magnus hits a sit-down slam and slowly goes up top. Magnus hits another elbow off the top but still only gets 2. Joe looks dazed as they both fight up. We get dueling chants from the crowd. Joe hits a Rock Bottom to a charging Magnus in the corner. Magnus goes out and grabs a chair but Joe flies over the top with a corkscrew to him on the floor. Back in the ring, Joe sets up for the Muscle Buster and hits it but Magnus kicks out and Joe can't believe it. Magnus tells him to bring it on in the corner. Joe applies a rear choke and Magnus fights but eventually passes out.
Winner by submission And STILL TNA Television Champion: Samoa Joe
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subset: commoncrawl


text: We checked out pics of Pete Doherty leaving court today looking all sorts of messed up (and sober, natch) and kinda had to wonder – would we hit it? Probably not, though throw in a couple other seedy options and we might. So in honor of our favorite game Who Would You Rather, we ask YOU dear reader, who would you rather get with? Sober, chunk-faced zit master Pete, the prop-loving monstrosity Carrot top, or this adorable cartoon potato we found using Google Image Search? Our pick has dreamy green eyes! [Getty]


text:
Apple Unlimited, Inc was formed in response to a demand for a more effective and personal results-driven marketing approach. Apple Unlimited Inc.'s professional marketing teams set up promotional events throughout the Greater Hampton Roads area to promote our clients' services, concepts, and products. There doesn't exist a medium that can be more exciting, authoritative, and commanding than that of a personalized message delivered on a one-on-one basis. More importantly, pure and simple, it works. Using our direct advertising methods and our relationships with major retail stores, we have consistently achieved dramatic results for clients, both large and small, throughout many industries.
Our event based approach allows professional representatives to take public relations to the grassroots level. However, it is our method for success that distinguishes us from your common marketing scheme. Through a direct approach, along with motivated individuals on their own personal path to success, we create an environment that inspires growth. Numerous businesses have taken advantage of the opportunities we present, which has resulted in up to 75% consumer expansion. With four simple marketing systems, which can be applied from production to distribution to management, we offer an exclusive approach that is driven by customer satisfaction and personal excellence. These combined factors not only offer distinction in quality and service, but also shape a profitable future for these multi-million dollar businesses.
By getting involved in the auto care industry we have branched off into many directions with our services. RGS Labs created the FW1 Waterless Formulation to meet a need in the racing world. Years ago, soap and water were used in the pit areas of the race track to keep the cars clean and the sponsors happy. Excess soap and water in this environment was found to get on the tires of vehicles and cause the drivers to lose traction. FW1 was designed to solve that problem. To give the public a chance to share in the same technology, we set up promotional demonstration teams to market the product.
We have also branched out into the chip repair world, where we can actually provide chip repair to the public at no cost to them. It helps to not only save the insurance companies money, but the consumer itself. The insurance companies are excited that we are saving them millions of dollars by repairing chips that have the potential to grow into cracks, which then would cause the need for full windshield replacement. This alliance allows our client to reach customers face-to-face and offer its top quality services directly to the customer. This unique, direct, personalized marketing and sales approach (combined with the convenient, superior mobile on-the-spot repair services) makes our client more than just a jingle on the radio, or an ad on TV. This new direction of the business has grown rapidly in only a short amount of time and we are excited about future growth opportunities within it.
Another strategy Apple Unlimited has found effective is taking our event marketing approach into the nation's leading members-only warehouse stores and large electronic retail stores to better promote our client's products and services. We have proven we can increase the customer base of the largest United States satellite service provider by effectively exposing their service by using our partnership with the large electronic retail stores. Give our professional representatives a chance to interact with a qualified customer in a comfortable environment, and we will ultimately bring results that our clients' expect. Now that these doors have opened, we have created a demand for our service to our clients more than ever.
Apple Unlimited, Inc. thrives in our industry because of a simple system of determination and organization. Combining this system with recognized national organizations, satellite service, and automotive performance products-we offer multiple solutions that work for each party involved. We are experiencing rapid growth and have developed an effective hands on training structure to aid in teaching and developing new personnel. Many members of our marketing team have taken advantage of the industry's tremendous growth and have advance rapidly into management and supervisory positions. We provide the opportunity for advancement to any individual willing to learn and determined to achieve success.
Apple Unlimited, Inc training includes:
- Creative event styles
- Public Relations
- Expert client management
- Team leadership
- Reliable and accountable supervision of events
Traditional advertising shows consumers "who & what" while teaching the "how & why." It is important for the consumer to fully understand the benefits and services of how a product performs. We stimulate this participation by providing non-intrusive channels where they can explore, experience, and discuss the need to be met.
Our Values and Beliefs
PEOPLE: At Apple Unlimited Inc., we are committed to helping others build essential skills for life. At the heart of our business is the fundamental belief that in order to be truly successful, we must first help others to succeed.
PROGRAMS: An important key to Apple Unlimited's growth is the strength of our mentoring program. By taking advantage of our training and opportunities for professional development, one will build personal and professional skills that will last a lifetime.
Apple Unlimited, Inc.'s road to success begins with training. Professors and business leaders throughout North America recognize our mentoring program as both highly effective and innovative. Specifically designed for individuals who have little or no business experience, the initial training can take from five to seven days. Training will be paid and will continue everyday that you work with Apple Unlimited. Through our success-driven approach individuals can expect to get hands on training from the moment they step foot in AUI. We pride ourselves in providing an opportunity for people to achieve success by having the right example to follow. We have seen tremendous results through our leadership approach. When you begin a division, you are mentored right from the start with your own personal coach. They will not only set the right example for you to follow, but will also guide you through various networking channels throughout our world-wide company. We have a sense of team built within our organization that provides a solidity that has proven to achieve maximum results.
We are looking for team players, creative thinkers and self starters who are goal and detail-oriented and have an affinity for working with people. Most openings require no experience and are considered entry level.
Opportunities are limited to candidates who are driven for advancement and can thrive in a high energy, enthusiastic work environment. This is a perfect opportunity for someone trying to get their "foot-in-the-door" in the marketing field.
Our Industry is growing rapidly, and we are looking forward to expanding coast to coast throughout the year. We are searching for people with an above average attitude for an above average opportunity.
We also want people who are motivated by 100% promotion from within. The average time for a person to graduate our mentoring program is five to nine months.


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3120 Allaire Road
Wall Township, NJ
FootGolf is now available on the Bel-Aire 9-Hole course. Contact the golf center for more information. FootGolf is available seven days a week.
2015 Fees & Charges | Scorecard with Map | FootGolf Scorecard I Hole-in-One Club
Daily Tee Time Schedule
Open year round, Bel-Aire Golf Course is a 27-hole facility, featuring an 18-hole executive par 60 course that has 6 par 4's, a 9-hole par 3 course, and a well-stocked golf center. Snacks and refreshments are available through vending machines. Bel-Aire is a wonderful place to learn the game of golf in a fun and relaxed setting. The Park System offers an extensive number of introductory and intermediate golf clinics for adults and juniors at Bel-Aire. Call 732-842-4000 ext. 1 for information on golf clinics and lessons.
Tee times at Bel-Aire 18-Hole Golf Course are available through the tee-time reservation system with the purchase of a Monmouth County Resident ID Card or a Non-Resident ID Card. Reserve a tee-time online or call 732-758-8393. The Bel-Aire 9-Hole Golf Course does not accept advance reservations, it is a walk-on, first come, first served facility. NEW: A children's rate (12 and under) of $5 is available daily at matinee times on the Par 3 9-Hole Course.


text:
Terrell Suggs
Roundtable: Would you rather have Orakpo or Suggs?
CSN Washington dot com -- let's see here you got one guy to come off the edge now. You want Brian Orakpo. 41 -- slopes toward the start you. You know as much potential as Brian Orakpo has I've got to go Terrell Suggs here defensive. Player of the year in 2011. He's been more consistent. You know it right now. But -- -- guy who didn't someday yes fired get fourteen sacks Terrell Suggs already done match. Die you know he he's he's a proven commodity. And in this league it's so important to put pressure on the opposing quarterback I got to go to guys proven some -- Suggs. -- -- At the risk of being caught -- -- laps to go was drugs as well. Suggs of the former defensive player of the year homer at his guys are talking about a guy. -- -- To me they want the best offensive player of the year they'll be in the league and this year Suggs looks great come and again he's a tremendous shape. He's having a great training camp. And this year I think he's wanted all more of a leadership role when ray Lewis and then B being gone I think Suggs as they -- the hard bit. A lot of people think the Ravens defense is -- -- that damn. He wants the media got to make sure that it doesn't and I think some -- -- having used -- -- Iraq was a lot of doubt I'll be fully recovered at the Goodyear. But I takes us. Aren't good luck getting an interview with Brian around by now are. CSN Washington dot com.
Video Results
CSN Update: Caps lose Game 3, Ravens lose Suggs
Washington dot com. Well there are conflicting reports on how one ravens' Terrell Suggs injured his Achilles last Saturday. From playing a pickup basketball game to Suggs claiming he was prepared for conditioning test. The extent of the injury
Suggs : 'We love everybody in this locker room'-1/22
CSN Washington dot com I was just make sure we and given to must notes it was time to go veg out there and try to traveling down. You know we we are so we had like a And Can't take have taken things from so. do on there. Needs to a man you know and also he did. And also what he did in We know we've
Can RG3 convert LeBron James to a Redskins fan?
right drafting. It means a lot ones. And as a person so. You know I think that's the hard. Now I noticed then Terrell Suggs is on the you share. It's great to have an excellent. Know you good ol' blog at this point in the game. A lot
Lunchbox Live - Redskins struggling - 11/1
Ravens did loss to the Jaguars. And Terrell Suggs called out the play calling after ..... we get on the same page. When Terrell Suggs calls out. Can't camera in the ..... because they're proven Terrel Suggs Ray Lewis Ed Reed. Defensive players
Suggs is a happy and impressive camper
Through five days of full-squad workouts, it has been difficult not to notice how good Terrell Suggs looks
Suggs 'honored' to assume leadership role
Terrell Suggs will be counted on to unofficially take the leadership role of the Ravens defense, having the longest tenure with the franchise following the departures of Ray Lewis and Ed Reed.
Is Terrell Suggs primed for a huge season?
After missing training camp and struggling with injuries in 2012, Terrell Suggs is healthy and eager for a new season.
Will Suggs and Ngata have stellar 2013?
Neither Terrell Suggs nor Haloti Ngata played their best football in 2012, but they are looking for a stellar 2013.
Will the Ravens have a stronger pass rush in 2013?
The Ravens' pass rush was nothing special in 2012, but it could be next season, led by Terrell Suggs and Elvis Dumervil.
Ravens' Suggs to be 'Sunday Night' star
The Ravens linebacker will do his part as a piece of the weekly NBC football opening.
Can Dumervil or Suggs win Deacon Jones Award?
The Deacon Jones Award will be given to the NFL's sack leader starting in 2013. Elvis Dumervil or Terrell Suggs would love to win it.
Player to watch at training camp: Elvis Dumervil
Elvis Dumervil has already excited many of his new teammates, most notably Terrell Suggs
Can Suggs and Ngata stay healthy in 2013?
The dynamic duo of Haloti Ngata and Terrell Suggs hope for a healthy 2013.
Suggs to Crabtree: 'See the big picture'
Michael Crabtree has a torn Achilles, an injury Terrell Suggs knows well. The Ravens linebacker has wisdom to share with the 49ers receiver.
Terrell Suggs could sizzle again in 2013
After an injury-plagued 2012, the Ravens hope Terrell Suggs returns to the top of his game this season.
Suggs could sizzle again in 2013
After an injury plagued 2012, the Ravens hope Terrell Suggs returns to the top of his game.
Suggs : 'I guarantee' every NFL team hates Patriots
Terrell Suggs joined WEEI Wednesday, telling The Big Show that he doesn't think that the New England Patriots 'respect anybody.'
Pats on the back from Suggs
The Raven lets New England know there's no off-season from hearing smack.
Ravens pool report: Suggs addresses teammates
Following the Baltimore Ravens' practice Thursday, John Harbaugh spoke to his players and was followed by veteran linebacker Terrell Suggs , who added his own two minute monologue.
comes you'll at least five overtime anything can happen after that. In the one shot that stands out to me was when Terrel Suggs you see him just now. You missed it kicker kicks. It's those times in my career as a and a isn't it didn't convert assists
CSN Washington dot com. SARS around for this from from Robert Griffin the third Terrelle Suggs and Jacoby Jones and others but it was the Wizards that played like the stars against the world champions if you're scoring at
but then you look at the injury issues you've got to Ray Lewis injury he's not gonna be back for a couple weeks. Terrel Suggs may or may not play this weekend but you also have an issue would He didn't play against the Pittsburgh Steelers in the pass
Achilles tendon. Well Davies used at the foot specialist Robert Anderson that's the same that Ravens linebacker Terrell Suggs he sucks he returned to the game last week just five months. After surgery. Not today davis' team Coca-Cola to
gonna take the Ravens are a couple of games too I just without. They're emotional leader Ray Lewis around. And who knows if Suggs can give back I mean he's trying to back an Achilles injury I don't think he plays this week and Cleveland and Indianapolis


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Republican presidential hopeful Jon Huntsman wants to toss out the Dodd-Frank rules on Wall Street and replace them with fees or new tax rules to head off another financial crisis.
In a Wall Street Journal op-ed on Wednesday, the long-shot GOP candidate asks: "Is Dodd-Frank an appropriate regulatory response to the 2007 financial crisis?" His answer: "Tragically, no."
Huntsman offers more than one prescription, saying: "The best would be to eliminate Dodd-Frank's backstop." And then he looks across the pond, arguing: "Congress should explore reforms now being considered by the U.K. to make the unwinding of its biggest banks less risky for the broader economy," including a fee on banks whose size is more than a given percentage of the GDP to cover the cost they'd impose on taxpayers if they were bailed out. Read the full op-ed.
– Robert Schroeder


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Bake instead of breaking your bank this holiday season
Joanne wants a watch, Bob wants a bike, Seth wants a iPod and little Carla wants a Barbie. Can't keep up? Can't afford to get everyone what they want this year for the holidays? Save yourself and bake something special for your friends and family this holiday season instead.
Baking for your friends and family is personal. You are putting time and effort into making something for them, while saving yourself some dough, or money that is. First you need some basic bread pans. You have a few decisions to make here. Do you want to give each person a single loaf? Or a few assorted miniature loafs? Depending on your grand plan, pick out your bread pans accordingly.
After you are all set with you bread pans, pick out a few bread and cake recipes that you want to try and that your friends and family will enjoy. Maybe Bob loves bananas. Find a recipe for banana bread. Hopefully it will be so delicious that he forgets all about that bike he wanted. You can make pumpkin bread, rosemary herb bread, or even a fancy cinnamon raisin bread. There are so many options.
Now you'll want to present the baked goods to your friends nicely instead of just handing them the bread pan and sending them off. Find some reasonable priced festive holiday-themed paper plates, cellophane wrapping and wide colorful ribbon.
Arrange the loaf or mini-loaves on the plate. Lay out a square of the cellophane wrap decorative side down. Place the plate in the center on top of the cellophane. Bring up the corners of the cellophane over the baked good/s, and tie it all together with a bow! Trust me freshly baked goods will not disappoint your friends and family.


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Green Electronics Challenge
Upcoming Events
No upcoming events scheduled...
Contact GPSA
P.O. Box 873402
Tempe, AZ 85287-3402
Phone: (480) 727-9870
Email: email@example.com
Search GPSA
Green Electronics: A US-China Maker Challenge is an international online competition focused on preventing the creation of electronic waste (e-waste). The competition is led by partners in the United States and China and is designed to inspire innovation, education, leadership, team-building and intercultural exchange. Our mission is to redefine the concept of "waste": Yesterday's cellphone battery could be tomorrow's treasure. Participants will be invited to upcycle or hack an electronic product to create a new electronic product; repair an electronic product; create a sustainable electronic product; and/or create artwork from used electronic products.
How the Competition Works
To participate, makers from both the United States and China can create green electronics solutions by:
- Repairing an electronic product
- Upcycling or hacking an electronic product to create a new electronic product
- Creating a sustainable electronic product; and/or
- Creating artwork from used electronic products
Makers post how they made their green electronics solution on Instructables.com. Applicants can submit as many times as they wish. The how-to videos and photo documentaries for the Green Electronics Challenge will be collected on Instructables.com. Following a round of public voting, a panel of judges will choose an equal number of winners to represent each country. Chinese participants will not be competing against US participants; rather, judges will choose the best selections from the English contest page and the Chinese contest page.
Learn more at www.greenelectronicschallenge.com.
Posted by Shane Moffet on Monday, April 14th, 2014 @ 11:09AM
Categories: News


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INDICOR The Paclitaxel-Eluting PTCA-Balloon Catheter in Combination With a Cobalt-Chromium Stent
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The INDICOR study is a controlled, prospective, multicenter, randomized, two arm phase-II real world study assessing the acute, 6 months, and 12 months and 3 year outcome of cobalt-chromium stent (Coroflex Blue) deployment followed by Paclitaxel-eluting PTCA-balloon dilatation (SeQuent Please) and of Paclitaxel-eluting PTCA-balloon dilatation (SeQuent Please) followed by cobalt-chromium stent (Coroflex Blue) deployment for the treatment of de-novo and restenotic lesions in native coronary arteries. The study will be conducted in India.
Coronary Heart Diseases
Device: Drug Eluting Balloon SeQuent Please
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
|Official Title:
|The Paclitaxel-Eluting PTCA-Balloon Catheter in Combination With a Cobalt-Chromium Stent to Treat Coronary Artery Disease in a Real World Scenario
- Late lumen loss at 6 months in-segment and in-stent for each treated coronary stenosis [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]
|Estimated Enrollment:
|Study Start Date:
|September 2008
|Estimated Study Completion Date:
|September 2016
|Primary Completion Date:
|September 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 1
Balloon first
Device: Drug Eluting Balloon SeQuent Please
Drug Eluting Balloon is followed by Bare Metal Stent
Other Name: SeQuent® Please DEB
Experimental: 2
Stent First
Device: Drug Eluting Balloon SeQuent Please
Bare Metal Stent followed by Drug Eluting Balloon
Other Name: SeQuent® Please DEB
Detailed Description:
The aim of the study is to evaluate the efficacy and safety of cobalt-chromium stent (Coroflex Blue) deployment followed by Paclitaxel-eluting PTCA-balloon dilatation (SeQuent Please) and of Paclitaxel-eluting PTCA-balloon dilatation (SeQuent Please) followed by cobalt-chromium stent (Coroflex Blue) deployment in a real world scenario including up to two de-novo or restenotic lesions ( no in-stent restenoses) in two different native coronary arteries (reference diameter: 2.5mm and 4.0mm, length of stenosis 10mm and 25mm) for procedural success and preservation of vessel patency up to 3 years
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients with stable angina pectoris (CCS class 1-3) or with unstable angina pectoris (Braunwald class 1-2, A-C) or documented ischemia or with documented silent ischemia
- Patients eligible for coronary revascularization by means of PCI
- Patients suitable for coronary revascularization of any sort (balloon angioplasty, device-assisted balloon-angioplasty or coronary artery bypass grafting)
- Patients must be older then 18 years of age
- Women of childbearing potential may not be pregnant nor have the desire to becoming pregnant during the first year following the study procedure. Hence, patients will be advised to use an adequate birth control method up to and including 6 months follow-up.
- Patients who are mentally and linguistically able to understand the aim of the study and to show sufficient compliance in following the study protocol
- Patients must agree to undergo the 6 months angiographic follow-up
- Patients must agree to undergo the 1 year and 3 year clinical follow-up
Lesion Related (relates to up to 2 stenoses in two different coronary arteries to be treated per protocol)
- Reference diameters ranging from 2.5 mm to 4.0 mm and length of stenosis from 10 mm to ≤ 25 mm
- Diameter stenosis pre procedure must be either more then 70 % or more then 50 % if ischemia corresponding to the target lesion is documented either by exercise stress ECG, stress echocardiography, or scintigraphy
- Coverage of the target lesion must be intended and possible by a single Paclitaxel-eluting balloon
Exclusion Criteria:
Patient Related
- Patients with acute (< 24 h) or recent (≤ 48 hours) myocardial infarction
- Patients with unstable angina pectoris (Braunwald class 3)
- Patients with severe congestive heart failure
- Patients with severe heart failure NYHA IV
- Patients demonstrating clinical signs of cardiogenic shock at the time of the procedure (systolic blood pressure of less than 80 mm Hg requiring inotropic support, IABP and/or fluid challenge).
- Patients with severe valvular heart disease
- Women who are pregnant or lactating
- Patients with life expectancy of less than five years or factors making clinical follow-up difficult
- Patients with bleeding diathesis in whom anticoagulation or anti-platelet medication is contraindicated
- Patients who had a cerebral stroke < 6 months prior to the procedure
- Patient participates in other clinical trials involving any investigational device or drug
- Untreated hyperthyroidism
- Patient has presence or history of severe renal failure (GFR<30ml/min) and is therefore not eligible for angiography. Patient's serum creatinine levels must be documented
- Post transplantation of any organ or immune suppressive medication
- Other disease to jeopardize follow-up (e.g., malignancy)
- Addiction to any drug or to alcohol
- Patients with any type of surgery during the week preceding the interventional procedure
- Patients with percutaneous coronary intervention during the six months prior to enrollment into this study
Lesion Related
- Evidence of extensive thrombosis within target vessel before the intervention
- Side branch > 2 mm in diameter originating from the lesion
- Percutaneous coronary intervention of venous graft
- Target segment is occluded of (i.e., acute or chronic)
- In-stent restenosis (restenoses in non-stented segments are permitted)
- Ostial lesion within 2 mm of vessel origin
- Patients with another coronary stent implanted previously into the target vessel proximal to the target lesion
Please refer to this study by its ClinicalTrials.gov identifier: NCT00747357
|Upendra Kaul
|New Delhi, India, 110025
|Principal Investigator:
|Upendra kAUL, Dr.
|Fortis Flt.Lt.Rajan Dhall Hospital, New Delhi, India
No publications provided
|Responsible Party:
|Ralf Degenhardt, PhD, Data Manager, Heart Centre Rotenburg
|ClinicalTrials.gov Identifier:
|NCT00747357 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 4, 2008
|Last Updated:
|March 17, 2015
|Health Authority:
|India: Institutional Review Board
Additional relevant MeSH terms:
Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Cardiovascular Diseases
Heart Diseases
Vascular Diseases
ClinicalTrials.gov processed this record on July 27, 2015


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|Two Youths Attempt Vehicle Robbery
|Written by Jared Linnen
|Saturday, 22 December 2012 08:10
Two youths are in police custody after allegedly trying to steal a vehicle in Edenwold.
An adult man was greeted by the young people at around 3:30 p.m. Friday outside of the Post Office.
When the man refused to hand over the keys, they fled on foot, but were eventually caught at an Edenwold residence.
Nothing was reported stolen and no one was injured.
(jl dec 22/12)


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Click Here to Watch the Whole Video in HD at Maverick Private Access
Exclusive Cam Videos and Pictures of the Hottest Amateur Guys
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fainted when i saw he had the whole package.
Mmmm. that body, that face, that treasure trail and hairy legs. Mmmmm
Breathtaking... And that was before he whipped out that massive, beautiful cock! :)
Hot looking dude...just don't care for the camera work...
shit, this guy is hot.


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Nobody uses fax machines anymore, so the Astros fired Tal Smith by phone.
I suppose they could have sent him a text, or tried to direct-message him on Twitter.
Look, it's hard to blame new owner Jim Crane for wanting a fresh start. As one long-time Astros person said to me Sunday night, Crane needs to look forward rather than back, and needs to start building something new.
Hiring George Postolos to replace Smith as club president and hiring a new general manager to replace the fired Ed Wade (Rangers assistant Thad Levine was a hot name Sunday night) are defensible moves, even inevitable moves.
But why do these firings have to be so messy?
When I heard from a source that Smith had been fired by phone, it brought back memories of August 1992, when Mike Ilitch officially took over the Tigers from Tom Monaghan.
Monaghan's last act, reportedly ordered by Ilitch as part of the same, was to fire club president Bo Schembechler and longtime club executive Jim Campbell.
Campbell, if I remember it right, was fired by phone. Schembechler (I'm sure of this) was fired by fax.
Campbell was 68 years old, and he had been with the Tigers for 43 of those years. Schembechler had been with the Tigers just 2 1/2 years, but he was a legend in the state.
Smith is 78. He just finished his 35th year with the Astros. He doesn't need to be club president anymore. But you'd think a new owner and new president might want to sit down and talk to him about the challenges ahead (who knows more about baseball in Houston?).
You'd even think that they wouldn't mind having him around in some capacity as the Astros celebrate their 50th anniversary in 2012.
Smith was there at the start, when they were the expansion Colt .45s. He was there when the Astrodome opened, and when the Astroturf went in, and he was there when Minute Maid Park opened.
He was there in 2005, when the Astros won the National League title for the only time in their history.
Now he's gone, and that's fine. Nobody deserves a job forever.
But anybody who did all that Tal Smith did deserves more than to be fired on a phone call.


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It's been a while since we've had a best and worst celebrity looks of the week, so here we go. This is from the last week of October. I chose Kelly Osbourne for best celebrity dressing up as another celebrity. That's her above as Christina Hendricks. Pretty dead-on.
I promise not to overdo it on the Halloween costumes.