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Originally Posted by Efrain Barragan on Tuesday, August 17, 2010
We're going to be out and about over the next few months at events all around the country. We know you can't all make the trip to visit us so we hope to see some of you when we come to your town. Here are just a few of the places we'll be.
Sipping Our Way Around the World in Hollywood
Bottlenotes is hosting their 80 Sips Around the World event in Hollywood this Thursday (August 19th) at the trendy h.wood lounge and eatery. We'll be pouring some new releases and enjoying the great food and wine.
Celebrating Labor Day Weekend in Tahoe
Wine tasting, live music and a silent auction all benefit the nonprofit organization Can Do Multiple Sclerosis at this Squaw Valley event. Over 40 wineries will be pouring at this event on Sunday, September 5th.
We really can be two places at once! We'll also be at the LA Times Celebration of Food & Wine event at Paramount Studios on Labor Day Weekend. This is going to be a great event with lots of amazing wine and food. September 5th.
Heading to the Rocky Mountains
More great food, wine and celebration at the Denver International Wine Festival. November 7th.
San Diego Bay Food & Wine Festival
One of our favorite events, this will be our fourth year attending. You can't beat the setting in beautiful, sunny San Diego. If you are at the event, be sure to check out both our wines and our tasty new gourmet food products. We'll have two tables. November 17-21.
Hope to see some of you there!
Originally Posted by Candice Crawford on Tuesday, August 10, 2010
Our 2009 Rte. Blanc Napa Valley Sauvignon Blanc released this week. This is a deliciously refreshing Sauvignon Blanc, perfect for a warm summer evening (if summer ever arrives in the Napa Valley!). The fruit comes from organic and sustainably farmed vineyards in Napa's Oakville and St. Helena appellations. Great aromatics of melons, fresh figs and orange blossom and lots of citrus and tropical flavors.
The 2009 was also bottled with our brand new labels. Hope you enjoy what we think is a sophisticated new look!
Available online at www.cliffamilywinery.com and in our tasting room. Stop by for a visit!
Originally Posted by Candice Crawford on Thursday, July 8, 2010
The day has finally come! Today marks the first day of harvest for our Clif Family Farm CSA Box and it is packed to the brim with lots of tasty veggies. This week's box includes a selection of swiss chard, zucchini, cucumbers, garlic, onions, and a bouquet of fresh flowers. Owner Kit Crawford, gardener Edie Kausch, and property manager Brad Crawford have been hard at work to bring this program to life. We could not be more excited to start the program and can't wait to see what the coming weeks bring.
For more information about the Clif Family Farm CSA Box program, contact Candice Crawford at email@example.com.
Originally Posted by Candice Crawford on Wednesday, July 7, 2010
Are you looking for something to do with all the delicious summer fruit that's now in season? A fun way to enjoy a chilled glass of white wine is to spice it up and make a white wine sangria. Sangria is easy to make and perfect for a hot summer day. Our 2008 Climber White makes particulary good sangria since there are abundant citrus and tropical fruit flavors already present in the wine. The added fruit only enhances the flavors and aromas in the wine.
To make sangria, you need fresh fruit, white wine and a jub large enough to hold about 12 cups (96 oz). The wine and the fruit should be on hand, it's the jug that may be difficult to find!
4 bottles Climber White Wine
1 bottle sparkling water
4 peaches
2 limes
2 lemons
2 oranges
Cut the lemon, limes, and oranges into slices. Then squeeze juices from the fruit and place slices in the jug.
Dice peaches and place in jug along with the other fruit.
Pour the wine into the jug along with all the fruit. Let sit overnight or for at least 8 hours.
Serve with sparkling water and ice.
You can also add the fruit as a garnish.
And if you are looking to buy some Climber White for this great recipe, we are offering 1-cent shipping on all UPS Ground Shipments throughout the month of July!
Originally Posted by Candice Crawford on Wednesday, June 30, 2010
Check out these photos of our new baby chicks. They are definitely not camera shy!
Originally Posted by Candice Crawford on Wednesday, June 30, 2010
Summer has finally arrived and we are already thinking about Fall!? But yes, it's that time of year to start thinking about harvest. And with so much going on around harvest time, we want to make sure you save the date for our 2nd Annual Clif Family Farm Harvest Party. If you were able to join us last year, you know that we can throw a great party. And this year it's going to be even better as you spend the day touring the farm (including our vegetable garden, olive orchard, honey bees and the site of our soon-to-be-planted vineyard), tasting delicious wines with our winemakers and enjoying a delicious array of foods. Our favorite pizza guys are making another appearance this year!
So if you are looking for a fun way to spend a beautiful fall day in September (September 18th, that is!), then come join us for this great event. Tickets are $75 for the general public and $50 for our wine club members and their friends. A portion of the proceeds from the event go to support our partner, the Community Alliance with Family Farmers. To purchase tickets, please give us a call at 707.968.0625 or email us at email@example.com.
Hope to see you there!


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You can prepare for a career in geology by completing a two-year Associate in Science degree program at Lake Michigan College and transferring credits to a four-year university.
The Geology program incorporates lecture and lab time in science-based courses.
"My goal for the geology program is to have students see how the world works, and in turn, have a greater appreciation of the Earth," says LMC program coordinator and instructor Dr. Cole Lovett. "Students will see the effects of our actions on the Earth, and hopefully leave the course with the mindset to safe-guard our world."
LMC instructors will expect you to be committed to your studies. Since many of these classes are introductory or general overviews, it is vital to your academic success to attend and actively participate in every class. LabsLabs require problem solving skills and teamwork. While working in pairs, you will conduct labs on topographical map reading, mineral identification, and rock identification.
With a maximum of 24 students to a class, you will have opportunities to ask questions and work closely with the instructor.
Overall, the geology courses offered at LMC are aimed at preparing you to be successful at a four-year college. LMC will provide you with the broad science knowledge you will need to succeed in higher-level courses.Technology in the ClassroomA variety of technologies are used in conjunction with traditional lecture and hands-on activities. PowerPoint presentations, videos, DVDs, the Internet and materials available on Canvas - the College's instructional Intranet - play an important role in class.Getting the Most from the Program"If students are struggling in class, I encourage them to come see me during office hours or go to the Tutoring Center," says Dr. Lovett. "It is important that students ask questions early on. This prevents falling behind in class."
By keeping in touch with your advisor, you can make sure you are on the right track to making a smooth transfer to a four-year school.
1 (800) 252-1562 or (269) 927-1000

subset: commoncrawl


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Unloved, Undervalued and Underowned
By James J Puplava CFP, January 24, 2005
If you have ever taken an investment course, read a book about investing, or talked to an investment advisor, you've been made aware of the importance of diversification. Diversification means different things to different people. To some it's having money in stocks, bonds, and cash. To others it's owning stocks in different sectors. To many it means owning domestic as well as foreign stocks and bonds. Diversification is used as a means of reducing risk. Yet today the application of diversification strategies is seriously flawed. Most advisors simply put their clients in diversified portfolios primarily made up of paper assets.
The basic elements of modern portfolio theory emanate from Professor Harry Markowitz as outlined in his 1959 paper "Portfolio Selection: Efficient Diversification of Investments."[1] The central theme of Markowitz's work is that rational investors should conduct themselves in a manner which reflects their inherent aversion to absorbing increased risk without compensation by an adequate increase in expected return. Risk was defined by Markowitz as the uncertainty, or variability of returns measured by the standard deviation of returns around the mean. Starting with the conception of risk and the assumed aversion to risk, investors should try to minimize deviations from expected portfolio returns by diversifying their security selections. This meant holding either different types of securities and/or securities of different companies. Markowitz pointed out that holding different issues wouldn't significantly reduce risk if the different securities contained a high degree of positive covariance. What Markowitz meant by that statement is that if the different securities held in the portfolio all moved in the same direction and magnitude or if their price movements were similar, risk would not be reduced.
To reduce risk in a portfolio it would be important to own securities that did not fluctuate in similar fashion. If one component of the portfolio was moving down, you would want to own assets that moved in the opposite direction. In other words, various components of the portfolio should be negatively correlated.
Markowitz's approach to investing has been criticized from both a theoretical and practical point of view. The greatest criticism relates to the assumption that rational investors are risk averters. In the bubble markets of the 1990s and the bubble markets of today investors have shown remarkable and consistent behavior in ignoring risk. One only has to look at stocks such as Google and Yahoo!, which sport triple digit P/Es. Then there are the IPOs such as last year's Marchex, which had only $23 million in sales and no earnings and yet the stock sports a $500 million market cap. Irrational behavior isn't confined only to individual investors. Professionals have been buying these stocks in addition to high risk assets such as junk bonds and foreign sovereign bonds with low credit ratings. The result is that credit spreads have narrowed considerably. So today's high risk investments offer very little in the way of a premium for taking on higher risk.
This criticism of Markowitz doesn't invalidate the concept of negatively correlated assets as a means of reducing risk. If everything in the portfolio moves in the same direction, then risk is not reduced. To reduce risk, various assets held in a portfolio should be negatively correlated. The investment class that is negatively correlated to stocks and bonds is commodities. In their research paper "Facts and Fantasies About Commodity Futures" professors Gary Gorton of Wharton and K. Geert Rouwenhorst of Yale show conclusively that commodities are negatively correlated with equity and bond returns. The main reason is due to the business cycle. The other is that commodities are positively correlated with inflation, unexpected inflation, and changes in expected inflation.[2]
In their study of investment markets and commodities from 1954-2004 the professors found the following:
- Commodity futures were negatively correlated with returns on the S&P 500 and long-term bonds.
- The negative correlation between stocks and bonds increase with the holding period.
- Commodity futures returns are positively correlated with inflation.[3]
What the professors showed from their research was that commodities as an asset class were negatively correlated to paper asset classes. When the financial markets did well as they did between 1982-2000 commodities did poorly. When paper markets performed poorly as they did in 2000-2002 commodities produced positive returns. This has a lot to do with the business cycle and inflation, which I will get to in a moment. More importantly, what the professors' work illustrated is that as an asset class commodities performed well when they were needed the most. As shown in the graph below, commodities produced a positive return when stocks and bonds were performing poorly.
Chart courtesy, Ron Greiss www.thechartstore.com note that the grey areas are noted as recessions
Commodities and Inflation
They did well in 1980, 1985-87, 1998-99, and in 2001-2004. These were periods of rising inflation and dollar weakness and periods of monetary expansion. When inflation begins to rise and the dollar declines, traditional assets such as stocks and bonds perform poorly. Inflation threatens the returns from fixed assets such as bonds eroding their purchasing power. They also threaten the returns from stocks. Inflation increases raw material and labor costs, which increases costs for companies and thereby reducing profit margins. Because of increased competition, these costs may not be able to be passed on to customers and therefore reduce company profit margins.
This correlation can be seen in the most recent profit reports from the third and fourth quarter of last year. Many companies reported higher costs, which couldn't be completely passed on to the consumer or customer. This was evident with companies like Alcoa, Kimberly-Clark, and GM. Companies are having to pay more for raw materials, health care costs and for energy. While they are able to raise prices, they aren't able to raise prices sufficiently to recover cost increases so margins shrink which reduces profits. In addition to rising costs, unexpected inflation can produce negative shocks to aggregate output, which is also negative news for equities.
The Business Cycle
Another reason that fits well with explaining the better performance of commodity type investments during periods of inflation is the nondiversifiable component associated with beta and the Capital Asset Pricing Model. This relates to the business cycle. Stocks and bonds perform poorly at the peak of a business expansion and during the early stages of a recession. As shown in the graph below of the business cycle, as the economy recovers and expands, this is a period when profits rise and interest rates fall. This is good for profits, which produces higher stock prices. Another influence on stocks and bonds is falling interest rates. Once an economy falls into recession, monetary policy becomes expansionary. The Fed reduces interest rates and expands credit through the banking system. Falling interest rates reduce the cost of borrowing and artificially increases the return from capital investments. This produces an economic boom. The increase in the supply of money and credit in the economy increases demand, which leads eventually to higher rates of inflation in either asset prices or in the cost of goods and services. As inflation rates heat up, the Fed is forced to curtail its expansionary policies by raising interest rates and contracting credit.
During various stages of the business cycle various asset classes perform differently. As shown in the graph above stocks and bonds begin to perform poorly at the peak of a business cycle as the Fed begins to raise interest rates. Stock and bond returns are also negative during the early phases of a recession. In contrast to stocks and bonds, commodities produce positive returns at the peak of a business cycle and during the early stages of a recession.
Examining the returns over seven business cycles from 1959 to the present, the professors quote the works of Weiser. In his study of seven business cycles, Weiser produced the following results in his study of asset classes:
- Between July 1959 and March 2004 average monthly returns on the S&P 500 and equally weighted commodity futures were remarkably similar at 10.8%, and 10.5%, respectively.
- They are also similar over economic expansions with 12.8% returns for the S&P 500 and 12.9% on equally weighted commodity futures.
- During late stages of expansion when stock and bond returns are below average commodity returns are positive and outperform both stocks and bonds.
- During the early stages of recession stocks, bonds and commodity returns are negative -15.5% and -2.9% respectively. By comparison the returns on commodity are positive by 3.5%. [4]
Defining this relationship further the professors looked at individual commodity returns during each phase of the business cycle. They found that certain commodities performed well during the late stages of an expansion and the early phase of a recession, but did poorly as the recession hit a trough. Specifically, energy, industrial materials, base metals, and food did particularly well. This can be seen not only in returns from individual commodities, but also from the performance of companies that produce them.
The study of commodity futures showed a positive correlation between commodities and their related equities. However, the performance of futures has been triple the cumulative performance of matching equities until recently. As the charts of ExxonMobil, BHP, and Bunge illustrate, stocks have performed relatively well in comparison to their respective commodities and in certain circumstances have performed even better.
A good example is the returns on Bunge in comparison to the performance of the commodities it processes: corn, wheat, and soybeans.
I believe the recent performance of commodity-related equities has a lot to do with our equity culture and the amount of money sloshing around the globe. Not all investors are sophisticated enough or knowledgeable enough to invest in commodity futures, so commodity equivalents are sought. There are only a few commodity related funds at this time - Rogers Raw Material, Pimco Commodity Real Return, and Oppenheimer Real Asset Fund, so investors and fund managers may find it more convenient to invest in commodity-related equities. In a world where asset markets from currencies to stocks and bonds have grown to tens of trillions of dollars, the commodity market is small by comparison. Commodities trade over $2 trillion dollars a day so on the surface the market is large. But imagine what would happen to the silver or gold markets, if only 5% of the money now held in stocks and bonds went into silver and gold bullion! We would be talking about prices considerably higher than where they are today. Therefore, I believe that commodity-related equities can do well in this environment.
As this new bull market in "things" as I like to call commodities unfolds, I'm sure the various exchanges will be coming out with commodity-related ETFs, so choices for investors will expand. However, we are just in the beginning stages of this new bull market that has much longer to run. What is important for investors to understand at this point is that every portfolio should include some form of commodity-related investments as a true means of diversifying a portfolio. As the chart above shows, commodity-related investments are inversely related to the returns on equities and bonds. If all you have in your portfolio is stock and bonds that are not commodity-related, then you really aren't diversified. If paper assets perform poorly as they did during 2000-2003, you need to be in other asset classes, especially those that perform well in recessions and periods of inflation or dollar devaluation. A chart of the S&P 500 Index, the US Dollar Index, and the Amex Gold Bugs Index (HUI) illustrates this point.
The Fundamentals
Perhaps you may be asking yourself or your investment advisor has told you that rising gold, oil, and various commodity prices are just a fluke. You need to dig deeper and your advisor (salesman) needs to give you a better explanation. If you don't own energy, precious metals, food, water, or base metal stocks in your account, you should ask why. As professors Gorton and Rouwenhorst have demonstrated in their research, commodity-related investments whether it is futures or matching equities are negatively correlated with equity and bond returns. They outperform general equities and bonds at the peak of a business cycle, which is where we are now and during the early stages in a recession, which is where we are headed. As far as risks are concerned, stocks and commodities are more volatile than bonds. To say commodity investments are risky and to not say the same for general equities is a falsehood. As shown in the graph of risk premiums taken from the Gorton/Rouwenhorst study, the risk are almost equal between futures and stocks.
I would argue it is even less for commodity-related companies such as an ExxonMobil or other high dividend paying resource stocks. As I wrote in a previous Observation from last year (see Trading Places) some of the best total returns (dividends plus capital appreciation) have been realized from the natural resource sector. As pointed out in Trading Places, utilities and natural resource stocks like energy have outperformed or exceeded the returns from the technology sector. They not only have outperformed, but have provided investors higher dividend yields that keep growing.
In his new book to be released this spring professor and author Jeremy Siegal argues that one of the biggest mistakes made by investors is overpaying for stocks. In their enthusiasm to embrace the latest rage or fad, investors pay too high a price resulting in poor returns. Siegal illustrates this by comparing the total return on IBM and Standard Oil of New Jersey now ExxonMobil going back to 1950. Both stocks did well over this time period, however the returns on ExxonMobil were 14.4% per year versus IBM's 13.8%. IBM was considered to be the premier growth stock of that era. Nevertheless, a $1,000 investment in IBM grew to 958,000. The same $1,000 invested in ExxonMobil grew to $1,260,000 some 25% greater.
The reason ExxonMobil outperformed IBM was because Exxon paid a higher return and sold for a much lower P/E multiple than IBM. The average P/E for Exxon was half of IBM's. In addition to a lower P/E multiple, ExxonMobil (then Standard Oil of New Jersey) offered a higher dividend yield enabling an investor who reinvested those dividends to accumulate 15 times as many shares. The combination of higher dividends and lower P/E multiple resulted in far superior returns with less risk.
Supply and Demand
While the lower P/E multiples and higher dividend yields of the resource sector look far more attractive than anything else in today's overvalued equity markets, there is another reason to own resource stocks. Plain and simple: they are in a new bull market. This new bull market in commodities is bound to be with us for a long, long time. The reason is basic; it's called supply and demand. There is simply more demand for commodities than there is supply. Demand has steadily increased each year as the world's population grows and emerging markets industrialize. At the same time that demand keeps growing, supplies of commodities are declining. Most major commodities are running a supply deficit that is made up of above ground stockpiles that are diminishing.
These supply deficits are the result of a long and protracted bear market in commodities. The laws of supply and demand dictate that when supplies are plentiful prices decline. However, when supplies are allowed to be depleted and demand continues to increase, the result is rising prices and a new bull market. In this regard the global supply-and-demand imbalance is completely out of sync. China is short just about every commodity it consumes from rice and soybeans to iron ore, steel, copper, and cement. What we now have occurring globally is the simultaneous industrialization of emerging economies such as China and India, which are now competing for commodities with the developed countries. The result is that demand is exploding at the same time that supplies are diminishing.
Source: All formats Barry Bannister, Legg Mason Wood Walker, Inc. Used by permission of Barry Bannister. For the U.S. stock market index: For the period 1871 to present the Cowles Commission U.S. stock market composite data from Standard & Poor's Corporation are joined with S&P 500 12-month annual average prices. For the PPI for All Commodities: For data from 1871 to 1890, the Warren & Pearson study, a U.S. commodity average constructed from the following components: farm products, foods, hides and leather, textiles, fuel and lighting, metals and metal products, building materials, chemicals and drugs, household furnishing goods, spirits, and other commodities. For the periods 1891 to 1913, the source is the Wholesale Commodities Price Index from the Bureau of Labor Statistics (BLS) and other agencies. For the period 1914 to present, the source is the PPI for All Commodities modern series.
Over the last two decades of the bull markets in stocks very little money went into maintaining or expanding the natural resource sector. Money flowed into Wall Street and Silicon Valley. The financial sector of the economy expanded, while the natural resource sector of the economy contracted. It has been close to 30 years since there has been a major oil discovery of equivalent size such as Prudhoe Bay or the North Sea. It has been equally as long since the last oil refinery was built in the U.S. In fact the number of oil refineries operating in the U.S. has dropped in half. At the same time the production of oil and natural gas in the western world, especially the U.S., has fallen consecutively each year. In addition to the supply of resources it has been decades since we've built a nuclear power plant in this country despite annual growth in electricity demand. From industrial to precious metals there have been very few large discoveries or new mines that have come on stream. As I wrote in Pac-Man, Clicks, & Bricks there have been very few gold discoveries made in the last decade despite rising demand for both gold and silver. At the same time as emerging markets industrialize, rural populations migrate to the city with prime agricultural land plowed under to put up a building or a parking lot. As a consequence, the food stock supplies have fallen to dangerously low levels.
|Gold Discoveries 1991 - 2002
|3Fields > 10 Million Ounces
|7Fields > 5 Million Ounces
|5Fields > 4 Million Ounces
|2Fields > 3 Million Ounces
|2Fields > 2 Million Ounces
|2Fields > 1 Million Ounces
Source: H.R. Bullis, "Gold Deposits, Exploration Realities, and the Unsustainability of Very Large GoldProducers," Canadian Institute of Mining, Metallurgy& Petroleum, EMG Vol. 10, No 4, March 24, 2003.
The result is that the world has grown over the last thirty years, but the basic infrastructure to support that world has fallen behind or in many cases has gone into disrepair. It takes 3-5 years from discovery to production of a new oil or gas well. It takes even longer, 5-7 years to discover and bring a new mine into production. It takes money, time, and effort to bring new agricultural land on line. The plain fact is that the world, especially the western world, has spent very little time, money or effort to expand, much less maintain its natural resource base. The result is the supply imbalances and deficits that we now see today. These imbalances won't go away any time soon. The world is just waking up to these supply imbalances. Even then because the price of finding new oil, natural gas, copper, lead, zinc, uranium, silver or gold, costs money, and the price for these commodities remain relatively cheap, it is easier for existing resource companies to buy existing reserves by acquiring other companies. The fact that the big boys in natural resources aren't spending as much as they should tells us a lot about the existing supply of most natural resources. Companies can find more oil, but they have to go to more remote and more dangerous parts of the globe to get it. Until prices rise substantially and for a considerable time, existing resource companies from mining companies to energy companies are unlikely to invest sufficient amounts of new capital. Companies need higher prices and those higher prices have to be maintained before capital flows freely into the sector.
What this means is that the new bull market in commodities or �things� is just in its formative stages. It should last at least another decade. These cycles keep repeating themselves. Over the last 130 years according to Barry Bannister of Legg Mason Wood Walker, paper asset and commodity cycles alternate every 18 years. Paper assets and commodities are once again trading places. The latest commodity cycle began in 1998 according to Jim Rogers, the year Rogers started his raw material fund at the bottom of the cycle. Since inception, the Rogers Raw Material Fund is up 176.11% as of December 2004.
For investors this means it is time to rethink your portfolio. We are now at the peak of an economic cycle, which means we are likely to head into a recession in the next 12 months. This is the time that commodities outperform nonresource equities and bonds. It is time to adequately diversify your portfolio. That means changing the way you think about investment markets.
The world changes as does the economic cycle. What worked in the last cycle won't work in this new cycle. The problem you may have is that commodities are the Rodney Dangerfield of investing�they get no respect. Too many investors, private and professional, have ignored this asset class. Most investment banks and brokerage firms don't even cover the sector or have only a few analysts that do. Many firms have shut down their commodity departments. Compare the number of analysts covering energy stocks, uranium or precious metals companies to the number of analysts following Cisco or Intel.
As the good professors Gorton and Rouwenhorst have shown, commodity investing has been plagued by ignorance, myths, and neglect. Commodities are truly worthy of their own investment merit, especially now as the economic cycle peaks. Commodities as an investment class "whether in raw material form or elated equities" is a smart way to diversify a portfolio as well as offer superior returns. As I wrote several years ago, they are about to become the Next Big Thing.
To learn more about commodity investing, I highly recommend reading "Facts and Fantasies About Commodity Futures" and Jim Rogers' excellent new book "Hot Commodities: How Anyone Can Invest Profitably in the World's Best Market."*
Today's Markets
Stocks started out in positive territory on Monday before worries over the pace and future course of earnings sent prices heading south. The Dow Industrials lost 24.38 points to close at 10,368.61, the S&P 500 gave back slipped 4.12 points to 1,163.75 while the Nasdaq dropped 25.57 points to finish the session at 2,008.70.
The major indexes extended their fourth straight day of losses giving back all of the gains of last year for the Dow. On Monday investors received warnings from Infineon Technologies. Many firms are blaming the inability of stocks to head North due to the slowdown in earnings. In addition to a slowdown in earnings there is also a more hawkish sounding Federal Reserve which is widely expected to raise rates at its February 1-2 meeting and subsequent meetings. The markets are facing incredibly strong headwinds- the ending of monetary and tax stimulus to name just a few.
In other markets March oil futures rose 28 cents to close at $48.81 a barrel on the New York Merc. IN overnight trading the price had risen to as high as $49.24. Bonds rose slightly with the 10-year note up 6/32nds with the yield falling to 4.12 percent. Gold futures closed up $.20 to $427.10. The dollar fell against the Euro. It remained flat against the yen.
Harry M. Markowitz, Portfolio Selection: Efficient Diversification of
Investments, Yale University Press, 1959.
[2] Gorton, Gary & Rouwenhorst, K. Geert, Facts and Fantasies About Commodity Futures, NBER Working Paper Series, Working Paper 10595, National Bureau of Economic Research, June 2004, p.16.
[3] Ibid., p.14.
[4] Ibid., p.21-25.
* [Note: Mr. Rogers will be Jim's guest expert on Saturday, February 5]
chart courtesy: www.stockcharts.com & www.thechartstore.com
James Puplava
© 2005 James Puplava
Contact Information
James J. Puplava CFP
PFS Group
PO Box 503147
San Diego, CA 92150-3147
(888) 486-3939 Toll Free
(858) 487-3939 Tel
(858) 487-3969 Fax


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Mahesh Bhupathi
21 Mahesh Bhupathi Articles
Lara Dutta: I am focusing on doing films now1 year ago 0
The actor is currently working on a sequel to her film Chalo Dilli Bollywood Actor Lara Dutta, who had taken a sabbatical post the birth of her… Read Article ▶
Yogen Shah
Lara Dutta, happy birthday!2 years ago 7
As this ex-Miss Universe and yummy mummy turns 35 today, we wish her a very happy birthday Born on April 16, 1978, Lara Dutta made her Bollywood… Read Article ▶
Lara Dutta and Mahesh Bhupathi show off their daughter Saira3 years ago 0
The couple was seen at the Chennai Open tennis tournament showing off their baby for the first time Lara Dutta and Mahesh Bhupathi were seen… Read Article ▶
BollywoodLife Awards 2012: Aaradhya Bachchan, Azad Rao Khan, Nitara Khanna Bhatia – Who is the cutest baby?3 years ago 5
Lots of cutie pies made their earthly appearance over the last year. And the B-town-crazy junta had eyes and ears open to know just when these star… Read Article ▶
Lara Dutta Bhupathi to get back to the shooting grind in January3 years ago 0
The self-confessed work worm seems super delighted at the idea of returning back to the big screen after a sabbatical Lara Dutta Bhupathi has it… Read Article ▶
Ranbir Kapoor and Abhishek Bachchan play football for a cause3 years ago 0
The actors were seen bonding over a football practice session. Prepping up for the final match in Delhi, RK and AB will be joined many other… Read Article ▶
Shilpa Shetty and Lara Dutta: back in style?3 years ago 0
Who said being a mommy was a full-time job? And even if it is, these mums have found a perfectly vogueish way around it! Many mommies have walked… Read Article ▶
B-towners congratulate Mahesh Bhupathi, Sania Mirza & Lara Dutta3 years ago 1
The tennis champions have been flooded with congratulatory messages from Bollywood, after they won the mixed doubles title at the French Open Mahesh… Read Article ▶
Lara Dutta shares fitness tips with to-be mommies3 years ago 0
The secret of the hot mom's well-toned curvaceous body even after delivering a baby is out. It comes in the form of a fitness DVD titled Prenatal… Read Article ▶
Lara Dutta, happy birthday!3 years ago 6
The gorgeous mommy Lara Dutta turns 34 today The former Miss Universe Lara Dutta was born to Wing Commander L.K. Dutta (retired), and Jennifer… Read Article ▶
Has Lara Dutta named her baby Saira Bhupathi?4 years ago 4
Something we read on a website makes us believe that it is true Lara Dutta gave birth to a baby girl today and the online world is already atwitter… Read Article ▶
Who looks better in 'Don 2′ – Shahrukh Khan or Lara Dutta-Bhupathi?4 years ago 8
Just when we thought Shahrukh Khan took the cake, icing and all, when it came to looking dishy as all heck in Don 2, we were proved wrong. Lara… Read Article ▶
Shahrukh Khan loves gold!4 years ago 2
Don 2's first song Zara dil ko thaam lo brings back memories of SRK-Kareena's Yeh mera dil When we watched the racy number Zara dil ko thaam lo from… Read Article ▶
Celina Jaitley pregnant?4 years ago 1
We informed you yesterday that Celina Jaitley got married a month ago in Austria, to her hotelier beau Peter Haag. Now there is a strong buzz that… Read Article ▶
Bigg Boss 5: Lara Dutta won't be a housemate4 years ago 1
The actor has denied rumours that she will be entering the reality show Speculation about the contestants on Bigg Boss 5 is running high, but one… Read Article ▶
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Hoarding Disorder Awareness Week
October 8th to October 15th, 2013
Governor Inslee has declared this week to be Hoarding Disorder Awareness Week in Washington State! View proclamation here The mission of The Hoarding Project is to promote awareness and accurate understanding of hoarding disorder. One way this is accomplished is through Hoarding Awareness Week. The King & Pierce Counties Hoarding Task Force has developed a variety of events to promote hoarding awareness. Please consider joining us in the Empathy Pledge [link] or by attending an awareness-raising event!
Hoarding Disorder Awareness Week Schedule
Tuesday, October 8, 2013
10-11am: Press Conference Kick Off
Location: Aging Optoins, 31919 Sixth Avenue South, Federal Way
6:30-8:30pm: The Hoarding Project Open House
Location: THP Office, 621 Pacific Ave, Suite 300, Tacoma 98402
Friday, October 11, 2013
10-2pm: Task Force Sponsored Free Community Training on Hoarding Disorder
Location: Seattle Housing Authority, 190 Queen Anne Ave N., Seattle
Register here
Saturday, October 12, 2013
9-4pm: Task Force Sponsored "Safety Day" (coordinated cleanout)
Location: Edgewood, WA (specific location to be given to volunteers)
RSVP to Volunteer: firstname.lastname@example.com
Tuesday, October 15, 2013
10-1pm: King/Pierce County Task Force Meeting and Free Community Lunch Celebration: Educational Presentation: Professional Panel on Collaborative Work with Hoarding Disorder
Location: Aging Options, 31919 Sixth Avenue South, Federal Way
RSVP: here


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Fri March 16, 2012
Hotel Alcatraz Isn't Exactly Like The Prison
By editor
Good morning. I'm Renee Montagne. Alcatraz Island was once home to Al Capone and Machine Gun Kelly. This week, a few lucky visitors are getting to spend a night in the Hotel Alcatraz. This version of the legendary prison is in London, not San Francisco Bay, part of a promotion for the sci-fi series Alcatraz that debuted in Britain this week. Hotel Alcatraz features guards instead of bellhops and rooms like cells. But a menu with something you wouldn't find behind bars - wine. It's MORNING EDITION. Transcript provided by NPR, Copyright National Public Radio.


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Since joining GeoEx in 2008, Natalie has traveled extensively throughout Central and South America, and recently took a four-month Latin American sabbatical, working on an organic farm in Costa Rica, trekking through the Andes of Peru, and tangoing her way through Argentina.
She loves everything about travel, from researching destinations to exploring them in person. And she's a pro at getting her guests to relax while she handles the planning and fine details. Her excitement about Latin America comes through loud and clear, whether she's raving about the food in Peru or the glaciers of Patagonia. If you are on the fence about taking a trip, she'll make you crack with her enthusiasm alone.
Natalie especially gets a kick out of surprising folks who have traveled with us before. For one couple, for example, she arranged a candlelight dinner and wine pairing in a Sacred Valley wine cave. And for another guest, whose business and passion was high-end home goods, she orchestrated a unique visit to a weaving community in Peru, suspecting that the textiles would offer the traveler new inspiration. (She was right!)
E-mail [email protected] directly or call 888-570-7108.
Phone: 415-922-0448Toll Free: 888-570-7108
Office Hours:Monday through Friday,8 a.m. to 5 p.m., Pacific time
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$2,399.99 After $400 OFF
Sleep Science Astoria 12" Split King Memory Foam Mattress with Adjustable Base
Item #743551
The Astoria Visco Memory Foam mattress is designed to be supportive with a soft sleeping surface. This mattress layers two different densities of visco memory foam to create a mattress that contours to the body while the air channel base provides the perfect level of support and air flow. The top 2 layers consist of 4 inches of 100% pure visco memory foam. These two layers are supported by the Sleep Science Air Channel base. The sitting edges of the mattress features the Sleep Science patented Wedge support system to create a stable sitting edge and maximizes the sleeping surface. The cover is removable and washable.
- Bed frame is not included
- Sleep Science comfort scale: Plush with medium support
- 12" Astoria visco memory foam mattress fits the dimensions of your bed
- Meets the requirements of 16 CFR Part 1633 – Federal Flammability (open flame) standards
- Limited Warranty: 20 Years
- Mattress cover sleeping surface is made with a polyester blend fabric and is removable and washable
- Mattress top layer: 2" proprietary premium 4lb slumber tech visco memory foam
- Middle layer: 2" proprietary 3lb slumber tech visco memory foam air flow
- Bottom layer: 8" Sleep Science patent pending air channel base made with support tech foam
- 4"x4" Patented wedge, edge support system
- Hypoallergenic and dust mite resistant
- Visco memory foam conforms to your body to relieve pressure points and improve circulation
- This mattress should rest upon a flat solid surface for best results
- First time visco memory foam sleepers, please allow 30-60 days to adjust to sleeping on a visco elastic memory foam mattress
- Visco memory foam is temperature reactive, therefore the mattress will react uniquely to each individual's body temperature
- The mattress is rolled and compressed for ease of delivery. There will be a slight foam odor when first opened that will dissipate within 24-48 hours.
- Split King (2 Twin Long) overall dimensions: 76" W x 80" L x 28" H Approx. Weight 428 lbs
The adjustable base has 3 pre-programmed positions on the wireless remote control:
- Zero Gravity (ZG): The ZG position, allows you to press one button and the bed automatically elevates both the head and feet for a feeling of floating suspension and cradling comfort
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- Standard King size features two individual Twin XL mattresses side by side
- Bed frame not included
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- Meets the requirements of 16 CFR Part 1633 – Federal flammability (open flame) standards
- Fits into most bed frames
- Can be used as a stand-alone bed
- Covered in camel colored micro-suede fabric
- Super quiet motor and operating system with power down system
- Wireless remote control, with back lighting and three programmed positions
- 3 pre-programmed positions (Zero Gravity, Reading and Flat), positions can be adjusted manually
- Massage feature for head, foot or both with three levels of intensity
- Operating mechanism and electronics UL tested
- Lifting capacity of 1400 lbs (700 lbs lifting capacity per each Twin XL adjustable base)
- 1 year In-Home warranty service warranty
- Years 2-5 free replacement of defective parts, purchaser responsible for freight and installation
- Limited lifetime warranty on mechanism
Collection Name: Astoria
Size of Bed Mattress: King
Standard shipping via White Glove* furniture carrier is included in the quoted price. Delivery includes in-home setup and removal of packing materials. Carrier will call or email to set up appointment with delivery window. Please include a daytime phone number in the shipping information at the time of checkout.
Extraordinary delivery requirements may necessitate an additional fee to the carrier.
If you have any customer service questions, order status inquiries, concerns regarding defective product, assembly of furniture or product operation, please call 800-723-0316 and ask for the Customer Service Department related to Costco.
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View Costco's Return Policy.
For information or a written copy of the manufacturer's warranty, please contact us at: firstname.lastname@example.com.


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Q&A with Mike Greenberg
Continued (page 5 of 5)
So tell me this story about your 40th birthday. Your wife was planning a surprise and all she told you is to bring your golf clubs.
Well, I told her wherever we go there better be golf involved. I think she figured that on her own. She didn't tell me where we were going or what we were doing. In addition to be a germaphobe, I'm also a bit of a control person and I felt out of control. As a consequence we weren't speaking for the first two hours of the trip. But in the end, golf was involved, and I was happy with that.
The reason why you wanted to know where you were going is it would affect the way you would pack your bag?
Well, I didn't know if we were getting on a plane or not. So if we are not getting on an airplane, I don't need the schlep the travel bag and it would affect where I pack my shoes. But she wouldn't even tell me if we were getting on a plane. I said, 'Stace, you have to tell me if we are getting on a plane because that will determine how I pack my golf clubs,' and that's how I finally found out we were getting on a plane.
So where did you go and where did you play?
We went to Montreal, and I played two golf courses up there. I played real well. I think I shot an 87 on one of them, and I have never been so happy with myself in my life.
You go to the Caribbean every year for Christmas? What's the draw there?
I like any number of things about it. Last year we went to a resort on the island of Great Exuma in the Bahamas, which has a Greg Norman-designed golf course, and what I like to do there is see how many balls I can lose. When you're in the Caribbean, and it's the same in Hawaii, all the courses are right on the water, and there's a ton of wind. And so it's windy, there's water, that's the only time I will go and buy the cheapest balls they have because I know I'm leaving sleeves on the course on a per round basis. That's the only time I will actually buy the used balls in the big bucket that have been fished out of the water. I take a dozen of those because I know I'm not leaving with any of them in my bag.
You were born in New York and went to school and worked in Chicago. Which city has better pizza?
People ask me that all the time. You really can't compare them. That's like saying, "Do you prefer hot dogs or hamburgers?" The traditional stuffed Chicago pizza, and the traditional thin-crust New York pizza have nothing in common. They're both called pizza, but outside of that they couldn't be less similar. I love both, but I don't use them for the same purpose. If it's going to be dinner, than I love nothing more than a good stuffed Chicago-style pizza with spinach and pepperoni and a good bottle of red wine--it's a spectacular dinner. But there's also nothing I love more, than if you're a little hungry, walking into Ray's Pizza at 6th Avenue and 11th Street and getting two slices and eating them while you walk down the street. They should not be compared to each other. It's like saying, do you like a driver better or a putter better? They're not the same thing.


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Year of publication
- 2001 (13) (remove)
- heavy ion collision (2)
- Gluon (1)
- Hypermaterie (1)
- J/psi Erhöhung (1)
- J/psi Unterdrückung (1)
- J/psi enhancement (1)
- J/psi suppression (1)
- Kerne (1)
- Kollision (1)
- Statistical coalescence model with exact charm conservation (2001)
- The statistical coalescence model for the production of open and hidden charm is considered within the canonical ensemble formulation. The data for the J/psi multiplicity in Pb+Pb collisions at 158 A·GeV are used for the model prediction of the open charm yield which has not yet been measured in these reactions.
- Hydrodynamic models for heavy ion collisions, and beyond (2001)
- A generic property of a first-order phase transition in equilibrium, and in the limit of large entropy per unit of conserved charge, is the smallness of the isentropic speed of sound in the mixed phase . A specific prediction is that this should lead to a non-isotropic momentum distribution of nucleons in the reaction plane (for energies < 40A GeV in our model calculation). On the other hand, we show that from present effective theories for low-energy QCD one does not expect the thermal transition rate between various states of the effective potential to be much larger than the expansion rate, questioning the applicability of the idealized Maxwell/Gibbs construction. Experimental data could soon provide essential information on the dynamics of the phase transition.
- Strange quark stars within the Nambu-Jona-Lasinio model (2001)
- We investigate the properties of charge neutral equilibrium cold quark matter within the Nambu Jona-Lasinio model. The calculations are carried out for di erent ratios of coupling constants characterizing the vector and scalar 4 fermion interaction, xi = GV /GS. It is shown that for xi < 0.4 matter is self bound and for xi < 0.65 it has a first order phase transition of the liquid gas type. The Gibbs conditions in the mixed phase are applied for the case of two chemical potentials associated with the baryon number and electric charge. The characteristics of the quark stars are calculated for xi = 0, 0.5 and 1. It is found that the phase transition leads to a strong density variation at the surface of these stars. For xi = 1 the properties of quark stars show behaviors typical for neutron stars. At >< 0.4 the stars near to the maximum mass have a large admixture of strange quarks in their interiors. PACS number: 14.65.-q, 26.60.+c, 97.10.-q
- Open and hidden charm production in heavy ion collisions at ultrarelativistic energies (2001)
- We consider the production of the open charm and J/psi mesons in heavy ion collisions at BNL RHIC. We discuss several recently developed pictures for J/psi production and argue that a measurement at RHIC energies is crucial for disentangling these di erent descriptions.
- J / psi suppression and enhancement in Au + Au collisions at the BNL RHIC (2001)
- We consider the production of the J/psi mesons in heavy ion collisions at RHIC energies in the statistical coalescence model with an exact (canonical ensemble) charm conservation. The cc quark pairs are assumed to be created in the primary hard parton collisions, but the formation of the open and hidden charm particles takes place at the hadronization stage and follows the prescription of statistical mechanics. The dependence of the J/psi production on both the number of nucleon participants and the collision energy is studied. The model predicts the J/psi suppression for low energies, whereas at the highest RHIC energy the model reveals the J/psi enhancement.
- Properties of dense strange hadronic matter with quark degrees of freedom (2001)
- The properties of strange hadronic matter are studied in the context of the modified quark-meson coupling model using two substantially di erent sets of hyperon-hyperon (Y Y ) interactions. The first set is based on the Nijmegen hard core potential model D with slightly attractive Y Y interactions. The second potential set is based on the recent SU(3) extension of the Nijmegen soft-core potential NSC97 with strongly attractive Y Y interactions which may allow for deeply bound hypernuclear matter. The results show that, for the first potential set, the hyperon does not appear at all in the bulk at any baryon density and for all strangeness fractions. The binding energy curves of the resulting N system vary smoothly with density and the system is stable (or metastable if we include the weak force). However, the situation is drastically changed when using the second set where the hyperons appear in the system at large baryon densities above a critical strangeness fraction. We find strange hadronic matter undergoes a first order phase transition from a N system to a N for strangeness fractions fS > 1.2 and baryonic densities exceeding twice ordinary nuclear matter density. Furthermore, it is found that the system built of N is deeply bound. This phase transition a ects significantly the equation of state which becomes much softer and a substantial drop in energy density and pressure are detected as the phase transition takes place. PACS:21.65.+f, 24.85.+p, 12.39Ba
- Microscopic colored quark dynamics in the soft nonperturbative regime : description of hadron formation in relativistic S+Au collisions at CERN (2001)
- The quark-molecular-dynamics model is used to study microscopically the dynamics of the coloured quark phase and the subsequent hadron formation in relativistic S+Au collisions at the CERN-SPS. Particle spectra and hadron ratios are compared to both data and the results of hadronic transport calculations. The non-equilibrium dynamics of hadronization and the loss of correlation among quarks are studied.
- Nuclei, superheavy nuclei, and hypermatter in a chiral SU(3) model (2001)
- A model based on chiral SU(3)-symmetry in nonlinear realisation is used for the investigation of nuclei, superheavy nuclei, hypernuclei and multistrange nuclear objects (so called MEMOs). The model works very well in the case of nuclei and hypernuclei with one Lambda-particle and rules out MEMOs. Basic observables which are known for nuclei and hypernuclei are reproduced satisfactorily. The model predicts Z=120 and N=172, 184 and 198 as the next shell closures in the region of superheavy nuclei. The calculations have been performed in self-consistent relativistic mean field approximation assuming spherical symmetry. The parameters were adapted to known nuclei.
- Kinetic equation for gluons at the early stage (2001)
- We derive the kinetic equation for pure gluon QCD plasma in a general way, applying the background field method. We show that the quantum kinetic equation contains a term as in the classical case, that describes a color charge precession of partons moving in the gauge field. We emphasize that this new term is necessary for the gauge covariance of the resulting equation.
- Partonic scattering cross sections in the QCD medium (2001)
- A medium modified gluon propagator is used to evaluate the scattering cross section for the process gg - gg in the QCD medium by performing an ex- plicit sum over the polarizations of the gluons. We incorporate a magnetic sreening mass from a non - perturbative study. It is shown that the medium modified cross section is finite, divergence free, and is independent of any ad-hoc momentum transfer cut-off parameters. The medium modified finite cross sections are necessary for a realistic investigation of the production and equilibration of the minijet plasma expected at RHIC and LHC PACS: 12.38.Mh; 14.70.Dj; 12.38.Bx; 11.10.Wx


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Young Philosopher Scholarships
The school is pleased to announce that scholarship funds are available for upcoming semesters for students already at Washington State University who have not yet reached junior status.
Academic excellence (3.0 GPA or greater) and proven interest in philosophy will be prime factors in the selection of recipients. Such excellence will be judged on the basis of the following:
- A transcript of graded course work.
- Demonstrated proficiency in writing—not merely in correctness of mechanics but also in the ability to select, organize, and present ideas effectively.
- Recommendations from philosophy faculty members.
- Performance in philosophy classes.
Financial need is normally not a consideration, and one need not be a philosophy major or minor to apply.
Decisions regarding the awarding of scholarships will be made by the Scholarship Committee. If you have any questions, contact the school at 509-335-2544 or firstname.lastname@example.com.
Application Deadline
Applications should be completed and submitted by 5:00 p.m. on March 24, 2014, for scholarships to be granted for fall semester. Applications can be turned into the office at 801 Johnson Tower or emailed to firstname.lastname@example.com
Earlier applications are encouraged, and decisions on some of the scholarships may be made prior to that date. The committee may also consider applications for mid-year admissions.


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|Foxo3L/L floxed mice may be useful for studying the regulatory role of the FOXO3 transcription factor on cell survival and tumor suppression.
Type Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) 22-JUL-15 Species laboratory mouse Generation N3+pN1f3 (30-JUN-14)
Generation Definitions
Donating Investigator Dr. Ronald DePinho, MD Anderson Cancer Center
These Foxo3L/L mutant mice possess loxP sites flanking exon 2 of the forkhead box O3 (Foxo3) gene. FOXO3 is a transcription factor which regulates the expression of genes involved in stress resistance, cell cycle progression, tumor progression, longevity, autophagy, and apoptosis. FOXO3 has also been shown to be a tumor suppressor. Mice that are homozygous for this allele are viable and fertile. When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will have exon 2 deleted in the cre-expressing tissue, resulting in inactivation of Foxo3 gene expression.
A targeting vector was designed to insert a loxP site, followed by a frt-flanked neomycin resistance (neo) cassette upstream of exon 2, and a single loxP site downstream of exon 2 of the forkhead box O3 (Foxo3) gene. The construct was electroporated into 129S6/SvEvTac-derived TC1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts and resulting chimeric mice were bred to FVB/N mice to establish a colony. The donating investigator reported that mice were bred to FVB mice for at least 3 generations before being bred with mice carrying Foxo4tm1Rdp and Foxo1tm1Rdp (see SNP note below). Upon arrival, mice were bred to FVB/NJ inbred mice (Stock No. 001800) for at least one generation to establish the colony. The three alleles in this strain were separated and maintained as separate strains (for Foxo4tm1Rdp see Stock No. 024757 and for Foxo1tm1Rdp see Stock No. 024756). Single mutants were bred to FVB/NJ for at least one more generation.
A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. Three of the 27 markers throughout the genome were segregating, suggesting an incomplete backcross.
|Considerations for Choosing Controls
Strains carrying other alleles of Foxo3
022097 B6N(Cg)-Foxo3tm1.1(KOMP)Vlcg/JView Strains carrying other alleles of Foxo3 (1 strain)
View Mammalian Phenotype TermsMammalian Phenotype Terms provided by MGIassigned by genotype
The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services email@example.com for customized breeding options.
Foxo3tm1Rdp/Foxo3tm1Rdp Tg(Ddx4-cre)1Dcas/0involves: 129S6/SvEvTac * FVB/N (conditional)
- endocrine/exocrine gland phenotype
- abnormal ovary physiology
- ovaries explanted at birth and cultured for 8 days grow more rapidly than controls (MGI Ref ID J:138697)
- abnormal primordial ovarian follicle morphology
- global primordial follicle activation (MGI Ref ID J:138697)
- enlarged ovary (MGI Ref ID J:138697)
- reproductive system phenotype
- abnormal ovary physiology
- ovaries explanted at birth and cultured for 8 days grow more rapidly than controls (MGI Ref ID J:138697)
- abnormal primordial ovarian follicle morphology
- global primordial follicle activation (MGI Ref ID J:138697)
- enlarged ovary (MGI Ref ID J:138697)
View Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Cell Biology Research
Cell Cycle Regulation
Research Tools
Cre-lox System
loxP-flanked Sequences
|Allele Symbol
|Allele Name
|targeted mutation 1, Ronald DePinho
|Allele Type
|Targeted (Conditional ready (e.g. floxed), No functional change)
|Common Name(s)
|FoxO3L; Foxo3f;
|Strain of Origin
|Gene Symbol and Name
|Foxo3, forkhead box O3
|Gene Common Name(s)
|1110048B16Rik; 2010203A17Rik; AF6q21; C76856; FKHRL1; FKHRL1P2; FOXO2; FOXO3A; Fkhr2; RIKEN cDNA 1110048B16 gene; RIKEN cDNA 2010203A17 gene; expressed sequence C76856;
|Molecular Note
|Exon 2, which is the first coding exon, was flanked by a loxP-frt-neo-frt cassette in intron 1 and single loxP site in intron 2. Mice carrying this allele were bred with cre transgenic mice to generate Foxo3tm1.1Rdp. [MGI Ref ID J:84269]
Genotyping ProtocolsFoxo1tm1Rdp, Standard PCR
Foxo3tm1Rdp, Standard PCR
Foxo4tm1Rdp, Standard PCR
Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Generic Neo Melt Curve Analysis, MELT
Tg(ACTFLPe), High Resolution Melting
Tg(ACTFLPe), Probe
Helpful LinksGenotyping resources and troubleshooting
Castrillon DH; Miao L; Kollipara R; Horner JW; DePinho RA. 2003. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301(5630):215-8. [PubMed: 12855809] [MGI Ref ID J:84269]
Foxo3tm1Rdp related
Ambrogini E; Almeida M; Martin-Millan M; Paik JH; Depinho RA; Han L; Goellner J; Weinstein RS; Jilka RL; O'Brien CA; Manolagas SC. 2010. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab 11(2):136-46. [PubMed: 20142101] [MGI Ref ID J:158622]
Bartell SM; Kim HN; Ambrogini E; Han L; Iyer S; Serra Ucer S; Rabinovitch P; Jilka RL; Weinstein RS; Zhao H; O'Brien CA; Manolagas SC; Almeida M. 2014. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun 5:3773. [PubMed: 24781012] [MGI Ref ID J:208828]
Battiprolu PK; Hojayev B; Jiang N; Wang ZV; Luo X; Iglewski M; Shelton JM; Gerard RD; Rothermel BA; Gillette TG; Lavandero S; Hill JA. 2012. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest 122(3):1109-18. [PubMed: 22326951] [MGI Ref ID J:184484]
Dejean AS; Beisner DR; Ch'en IL; Kerdiles YM; Babour A; Arden KC; Castrillon DH; DePinho RA; Hedrick SM. 2009. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol 10(5):504-13. [PubMed: 19363483] [MGI Ref ID J:148279]
Deng X; Zhang W; O-Sullivan I; Williams JB; Dong Q; Park EA; Raghow R; Unterman TG; Elam MB. 2012. FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J Biol Chem 287(24):20132-43. [PubMed: 22511764] [MGI Ref ID J:186518]
Gan B; Lim C; Chu G; Hua S; Ding Z; Collins M; Hu J; Jiang S; Fletcher-Sananikone E; Zhuang L; Chang M; Zheng H; Wang YA; Kwiatkowski DJ; Kaelin WG Jr; Signoretti S; DePinho RA. 2010. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18(5):472-84. [PubMed: 21075312] [MGI Ref ID J:166830]
Goertz MJ; Wu Z; Gallardo TD; Hamra FK; Castrillon DH. 2011. Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis. J Clin Invest 121(9):3456-66. [PubMed: 21865646] [MGI Ref ID J:178240]
Haeusler RA; Kaestner KH; Accili D. 2010. FoxOs function synergistically to promote glucose production. J Biol Chem 285(46):35245-8. [PubMed: 20880840] [MGI Ref ID J:167017]
Haeusler RA; Pratt-Hyatt M; Welch CL; Klaassen CD; Accili D. 2012. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab 15(1):65-74. [PubMed: 22197325] [MGI Ref ID J:182348]
Herzog S; Hug E; Meixlsperger S; Paik JH; DePinho RA; Reth M; Jumaa H. 2008. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol 9(6):623-31. [PubMed: 18488031] [MGI Ref ID J:136355]
Iyer S; Ambrogini E; Bartell SM; Han L; Roberson PK; de Cabo R; Jilka RL; Weinstein RS; O'Brien CA; Manolagas SC; Almeida M. 2013. FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest 123(8):3409-19. [PubMed: 23867625] [MGI Ref ID J:201398]
John GB; Gallardo TD; Shirley LJ; Castrillon DH. 2008. Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth. Dev Biol 321(1):197-204. [PubMed: 18601916] [MGI Ref ID J:138697]
Kim-Muller JY; Zhao S; Srivastava S; Mugabo Y; Noh HL; Kim YR; Madiraju SR; Ferrante AW; Skolnik EY; Prentki M; Accili D. 2014. Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice. Cell Metab 20(4):593-602. [PubMed: 25264246] [MGI Ref ID J:215526]
Lin A; Yao J; Zhuang L; Wang D; Han J; Lam EW; Gan B. 2014. The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene 33(24):3183-94. [PubMed: 23851496] [MGI Ref ID J:212581]
Milan G; Romanello V; Pescatore F; Armani A; Paik JH; Frasson L; Seydel A; Zhao J; Abraham R; Goldberg AL; Blaauw B; DePinho RA; Sandri M. 2015. Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun 6:6670. [PubMed: 25858807] [MGI Ref ID J:222729]
Ouyang W; Beckett O; Ma Q; Paik JH; DePinho RA; Li MO. 2010. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol 11(7):618-27. [PubMed: 20467422] [MGI Ref ID J:161859]
Paik JH; Ding Z; Narurkar R; Ramkissoon S; Muller F; Kamoun WS; Chae SS; Zheng H; Ying H; Mahoney J; Hiller D; Jiang S; Protopopov A; Wong WH; Chin L; Ligon KL; DePinho RA. 2009. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5(5):540-53. [PubMed: 19896444] [MGI Ref ID J:154024]
Paik JH; Kollipara R; Chu G; Ji H; Xiao Y; Ding Z; Miao L; Tothova Z; Horner JW; Carrasco DR; Jiang S; Gilliland DG; Chin L; Wong WH; Castrillon DH; DePinho RA. 2007. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128(2):309-23. [PubMed: 17254969] [MGI Ref ID J:118179]
Park Y; Jin HS; Lopez J; Elly C; Kim G; Murai M; Kronenberg M; Liu YC. 2013. TSC1 regulates the balance between effector and regulatory T cells. J Clin Invest 123(12):5165-78. [PubMed: 24270422] [MGI Ref ID J:207832]
Rached MT; Kode A; Xu L; Yoshikawa Y; Paik JH; Depinho RA; Kousteni S. 2010. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab 11(2):147-60. [PubMed: 20142102] [MGI Ref ID J:158621]
Ren H; Plum-Morschel L; Gutierrez-Juarez R; Lu TY; Kim-Muller JY; Heinrich G; Wardlaw SL; Silver R; Accili D. 2013. Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons. Diabetes 62(10):3373-83. [PubMed: 23835335] [MGI Ref ID J:208948]
Renault VM; Rafalski VA; Morgan AA; Salih DA; Brett JO; Webb AE; Villeda SA; Thekkat PU; Guillerey C; Denko NC; Palmer TD; Butte AJ; Brunet A. 2009. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell 5(5):527-39. [PubMed: 19896443] [MGI Ref ID J:154025]
Rosborough BR; Raich-Regue D; Matta BM; Lee K; Gan B; DePinho RA; Hackstein H; Boothby M; Turnquist HR; Thomson AW. 2013. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood 121(18):3619-30. [PubMed: 23444404] [MGI Ref ID J:197572]
Roupe KM; Veerla S; Olson J; Stone EL; Sorensen OE; Hedrick SM; Nizet V. 2014. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One 9(2):e89274. [PubMed: 24586650] [MGI Ref ID J:213755]
Sengupta A; Molkentin JD; Paik JH; DePinho RA; Yutzey KE. 2011. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem 286(9):7468-78. [PubMed: 21159781] [MGI Ref ID J:170395]
Sullivan JA; Kim EH; Plisch EH; Peng SL; Suresh M. 2012. FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms. PLoS Pathog 8(2):e1002533. [PubMed: 22359505] [MGI Ref ID J:195402]
Sykes SM; Lane SW; Bullinger L; Kalaitzidis D; Yusuf R; Saez B; Ferraro F; Mercier F; Singh H; Brumme KM; Acharya SS; Scholl C; Tothova Z; Attar EC; Frohling S; Depinho RA; Armstrong SA; Gilliland DG; Scadden DT. 2011. AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias. Cell 146(5):697-708. [PubMed: 21884932] [MGI Ref ID J:176214]
Tao R; Wei D; Gao H; Liu Y; Depinho RA; Dong XC. 2011. Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene. J Biol Chem 286(16):14681-90. [PubMed: 21388966] [MGI Ref ID J:171118]
Tao R; Xiong X; DePinho RA; Deng CX; Dong XC. 2013. FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem 288(41):29252-9. [PubMed: 23974119] [MGI Ref ID J:203942]
Tao R; Xiong X; DePinho RA; Deng CX; Dong XC. 2013. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 54(10):2745-53. [PubMed: 23881913] [MGI Ref ID J:202625]
Tothova Z; Kollipara R; Huntly BJ; Lee BH; Castrillon DH; Cullen DE; McDowell EP; Lazo-Kallanian S; Williams IR; Sears C; Armstrong SA; Passegue E; DePinho RA; Gilliland DG. 2007. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128(2):325-39. [PubMed: 17254970] [MGI Ref ID J:117892]
Tsuchiya K; Accili D. 2013. Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance. Diabetes 62(5):1478-89. [PubMed: 23349480] [MGI Ref ID J:208573]
Tsuchiya K; Tanaka J; Shuiqing Y; Welch CL; DePinho RA; Tabas I; Tall AR; Goldberg IJ; Accili D. 2012. FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab 15(3):372-81. [PubMed: 22405072] [MGI Ref ID J:182672]
Tsuchiya K; Westerterp M; Murphy AJ; Subramanian V; Ferrante AW Jr; Tall AR; Accili D. 2013. Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice. Circ Res 112(7):992-1003. [PubMed: 23420833] [MGI Ref ID J:213325]
Webb AE; Pollina EA; Vierbuchen T; Urban N; Ucar D; Leeman DS; Martynoga B; Sewak M; Rando TA; Guillemot F; Wernig M; Brunet A. 2013. FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis. Cell Rep 4(3):477-91. [PubMed: 23891001] [MGI Ref ID J:201905]
Xiong X; Tao R; DePinho RA; Dong XC. 2012. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J Biol Chem 287(46):39107-14. [PubMed: 22992773] [MGI Ref ID J:192959]
Yeo H; Lyssiotis CA; Zhang Y; Ying H; Asara JM; Cantley LC; Paik JH. 2013. FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells. EMBO J 32(19):2589-602. [PubMed: 24013118] [MGI Ref ID J:202479]
Zhang K; Li L; Qi Y; Zhu X; Gan B; DePinho RA; Averitt T; Guo S. 2012. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 153(2):631-46. [PubMed: 22147007] [MGI Ref ID J:181743]
Animal Health ReportsRoom Number AX9
Colony Maintenance
Breeding & Husbandry When maintaining a live colony homozygous mice may be bred together. Mating System Homozygote x Homozygote (Female x Male) 22-JUL-15
|Pricing for USA, Canada and Mexico shipping destinations
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $246.90 Female or Male Homozygous for Foxo3tm1Rdp
Price per Pair (US dollars $) Pair Genotype $493.80 Homozygous for Foxo3tm1Rdp x Homozygous for Foxo3tm1Rdp
Standard Supply
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.
|Pricing for International shipping destinations
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $321.00 Female or Male Homozygous for Foxo3tm1Rdp
Price per Pair (US dollars $) Pair Genotype $642.00 Homozygous for Foxo3tm1Rdp x Homozygous for Foxo3tm1Rdp
Standard Supply
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.
|Considerations for Choosing Controls
|Control Pricing Information for Genetically Engineered Mutant Strains.
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