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Join in Walk-His-Way Walk-A-Thon
JENSEN BEACH - Trinity United Methodist Church youth groups are excited to be hosting The Walk-His-Way Walk-A-Thon for House of Hope on Saturday April 13, starting at 9 a.m. at Trinity United Methodist Church, 2221 NE Savannah Rd. in Jensen Beach (next to the post office).
Walkers are invited to help raise money for this awesome organization that offers a "hand-up" to families throughout Martin County. Register to walk at www.trinityJB.org or by stopping by the church office Monday through Friday, 10 a.m.–3 p.m. or Friday 9 a.m.–noon.
There is a suggested pledge amount of $50 that you can collect from friends and family to become a walker, however, any amount of pledge money will be accepted, whether it is more than $50 or less than $50. Just join the walk and do whatever you are able to help The House of Hope to help others.
The walk route will proceed from Trinity United Methodist Church, down Savannah Rd., left onto Jensen Beach Blvd. and left into Pineapple Park for a refreshment stop. Then the route will be reversed back to the church with a water stop also available at TD Bank. Upon your return to the church, lunch, awards and some awesome entertainment will be provided.
Please join to walk for this worthy cause. Sherriff Snyder will be joining at 9 a.m. to get the race started.
Register at www.TrinityJB.org or call 772-334-3404.
This story is contributed by a member of the community and is neither endorsed nor affiliated with TCPalm.
Subscribe to TCPalm.com and our Treasure Coast Newspapers
Need Help? Call us at 1-877-710-6180.
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text: Appearing as late as mid August, Tristan will be a part of the Luke and Laura reunion scheduled for November. What Tristan does say according to his online guestbook on his website http://www.tristanrogers.com is "that there is a serious lack of story for his character and has not done much in the past few months". Still, he wrote, "the show has the potential to rise above it all" and he looks forward to some interesting plots and twists to come.

subset: commoncrawl


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The ASA St. Louis Chapter 049 is pleased to announce that it is in the running for the 2013–2014 ASA Outstanding Chapter Educational Event Award, which is given out each year to an ASA chapter-hosted educational event that highlights the excellent work, dedication and contributions of chapter members to the appraisal profession during the last fiscal year (July 1, 2013 – June 30, 2014).
On Friday, April 25 and Saturday, April 26, 2014, the ASA St. Louis Chapter 049 sponsored and hosted the ASA Healthcare Special Interest Group (HSIG) two-day, in-person course session at the Saint Louis Airport Marriott, featuring a blockbuster faculty of healthcare industry experts. The conference, entitled, "The Four Pillars of the Healthcare Industry: A Review of the Reimbursement, Regulatory, Competitive, and Technological Environment for Healthcare Valuation," is an integral part and course requirement for earning the "Certificate of Completion" of ASA HSIG's Multidisciplinary Advanced Education in Healthcare Valuation Program. The public relations efforts of the ASA St. Louis Chapter (2009 winner of the ASA Best Chapter Public Relations Program Award) generated positive national attention for ASA, and promoted the Society as the premier international organization devoted to multidisciplinary quality education in the healthcare appraisal profession.
The lastest Chapter E-Letter has been posted. If you did not receive your letter please contact Christine Stefl at email@example.com
We encourage your feedback. If you have comments or suggestions for the Chapter E-Letter or if you have information you would like to submit for inclusion, contact Christine Stefl at email@example.com
Congratulations to the Chapter! In recognition of the Chapter's E- Letter, the Chapter was the recipient of the ASA's "Best Chapter Newsletter" award. Ernie Demba accepted the award on behalf of the Chapter at the American Society of Appraiser Conference in Washington, DC. Our first chapter E-Letter was published in September of 2009. The Chapter was recognized for the "Best Chapter Newsletter"award in 2010 as well.
Please contact any chapter officer or membership chair, Mary Carpenter at email@example.com
We encourage your submission of material you would like to share or feel would be of interest to our local chapter members and the general public. Please contact Kyle Krahl at firstname.lastname@example.com to have your material posted on the site.
Copyright 2015


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Its Wednesday afternoon and I'm only just getting to this post- Oops! I did pretty lousy on last week's Ten Things Tuesday, finishing only 5 of them. A few of these, as usual, will carry over into the next week, but there will be a few new ones on the list as well.
Here's last week's Ten Things.
- Finish reading Burning Chrome. Nope… I'm about 1/3rd of the way through it.
- Finish sewing my bordered 1/2 circle skirt. Done!
- Sew my blue polka dot top. Nope. Didn't even get started.
- Vacuum the house twice. Done!
- Lose 1.5 pounds. Hahaha! Did you see my last couple of days?
- Have 30 Points+ left over at the end of the week. Um… Highly doubtful, especially as I'm not sure of what all I ate on Saturday night.
- Brush the dogs twice. Done!
- Decide what to do about some of the clothes in my closet I will probably never wear. Done! I've listed a bunch of them in my shop for super cheap.
- Add five new things to my shop. Yup- see #8.
- Do not keep shoveling food into my face at Tracy & David's BBQ this Saturday. Done! I actually did really well here and didn't overdo it too much while we were there. Of course it helped that I was exhausted and had eaten a burrito before we left.
This week I will try to:
- Finish reading Burning Chrome.
- Vacuum the house twice.
- Brush the dogs twice.
- Lose 1.5 pounds.
- Finish sewing two new projects.
- Stay on target this week on eating for the rest of the week.
- Get to 170 Likes on my Kittyloaf Designs Facebook page. *nudge nudge*
- Sell something.
- Try one new recipe.
- Catch up on my blog reading.
Food Tuesday was so-so. I had no idea that a Drumstick had 10 Points+ in it or I wouldn't have eaten it. Ugh. Still, it was good though. Other than that I stayed on track and didn't screw up, despite the carrots we had at dinner being almost dessert-like with how I prepared them. Here's Tuesday's food diary.
|Cottage Cheese (1 Cup)
|Coffee w/Coffeemate
|BBQ Chicken Thigh
|Carrots w/Butter & Sugar
|Rice-a-Roni Creamy Four Cheese (½ Box)
|Drumstick Vanilla Fudge (1)
|Food Totals
Nothing else for today, so going to hit post and see you all tomorrow!


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Latest Headlines
"Miller Time" Once Again for the Leafs
Posted on 27 Nov 2010 by RJ Emptage.
Kicking off the first of two divisional games on consecutive nights, the Toronto Maple Leafs traveled a short trip down the QEW to take on the Buffalo Sabres at the HSBC Arena in the second of six meetings between the two teams. After tonight's 3-1 victory, the Sabres now hold a 2-0 record against the Leafs following a 3-2 shootout decision on Nov. 6 in Toronto. During most of Monday'...
Continue Reading
Capital Heartbreak
Posted on 4 Nov 2010 by RJ Emptage.
After a few late goals in Tuesday's loss against the Ottawa Senators, the Toronto Maple Leafs look to keep their offense consistent, and who better to take notes from than the high flying Washington Capitals. Sidelined 4-6 weeks with a deep laceration to his leg, the Maple Leafs took to the ice without Captain Dion Phaneuf. Coming out with a steady pace and containing the flurry of chances cert...
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4-0 honeymoon is over for Leafs Nation
Posted on 29 Oct 2010 by Ben Fisher.
Sports can be funny sometimes. It's pretty clear now that the Leafs aren't as good as they seemed after jumping out to a 4-0 start to the season. I also feel, however, that their 1-3-1 slide in their past five games is not indicative of this team on the whole. Yet, amidst this pursuit of determining who the Buds are and where they should stand based on their collective abilities, we get a 5...
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Looking For A Spark
Posted on 25 Oct 2010 by RJ Emptage.
The Toronto Maple Leafs are living the reality of the difference one week can make, when it comes the NHL standings. Blazing out of the gate to record the first 4-0 start since 1993-1994, the fire has been extinguished through the last week of action with losses to the New York Islanders, New York Rangers, and Philadelphia Flyers. With a now modest record of 4-2-1, Head Coach Ron Wilson has beg...
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Leafs Nation: The Beat Goes On…4-0-1
Posted on 20 Oct 2010 by Mike De Petrillo.
It was bound to happen – the Leafs lost a game. I have taken shelter in my underground layer awaiting the apocalypse that is sure to come at some point before Thursday's match-up with the Rangers… Wait, what? The Leafs still got a point? They have garnered 9 of a possible 10 available points to begin the 2010/11 season? Okay, time to release the air lock; I am coming back abov...
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Wilson has Leafs Working Hard
Posted on 19 Oct 2010 by Ben Fisher.
Go figure: the Leafs' first loss of the season – in their first game against a team not expected to contend for a play-off spot – might have been their best full-game effort yet. Yes, the team's lack of a single shot in the overtime frame suggested a lack of offensive finish behind Phil Kessel. And yes, Matt Moulson's second period marker came as a result of a defensive breakdown that...
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Couldn't Last Forever
Posted on 19 Oct 2010 by RJ Emptage.
Although the feeling was that of the lowest point of the season, the Toronto Maple Leafs need and deserve to keep their heads held high after suffering their first loss of the early NHL season at the hands of the New York Islanders. In a game where all players performed and continued to compete, the outcome was perhaps attributed a few "bad" calls and a lack of "puck luck̶...
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Leafs Bite Back In The "Big Apple"
Posted on 16 Oct 2010 by RJ Emptage.
Looking to start the season 4-0 for the first time since the glory days of 93-94, the Toronto Maple Leafs took to Broadway to display their new found attitude. In their first game at home the New York Rangers came out with a jump, much to the delight of the MSG faithful, and captured the early lead. Not once in this young season have the Maple Leafs surrendered the first goal, however the team ...
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Winds of Change
Posted on 15 Oct 2010 by RJ Emptage.
Short of a complete roster overhaul, Brian Burke had one objective in mind as he took the thrown in the center of the hockey universe – change the culture. While the pink slips delivered to players from years passed who were enamored within a losing environment make room for new changes, it was the selection of certain players all with unique characteristics that has restored the right at...
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Sign of Things to Come?
Posted on 10 Oct 2010 by RJ Emptage.
Round 1 of the battle of Ontario and it seems the Toronto Maple Leafs haven't missed a beat. Securing their opening night victory against the Montreal Canadiens, the Leafs welcomed the Ottawa Senators to the ACC in a game dominated by the home team. Looking to over-shadow last seasons horrific start, the Leafs showed relentless puck pursuit from the opening face-off and never looked back in ach...
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Too Little Too Late?
Posted on 30 Sep 2010 by RJ Emptage.
While it certainly was the performance he was looking for and desperately needed, Nazem Kadri may still find that his impression was needed much sooner in order to secure a job within the NHL to start the 2010/2011 season. The 19 year old showed signs of the player Leafs' management was hoping to see from the outset of pre-season in a 4-3 victory over divisional rival Ottawa Senators. The 2 goa...
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One Week Into Pre-Season: Review
Posted on 28 Sep 2010 by RJ Emptage.
After one full week of pre-season action the Toronto Maple Leafs roster is beginning to take shape. With a mild record of 3-2-1 and most rookies already cut from the roster, Ron Wilson will begin to erase the penciled names and solidify them in ink aiming towards the opening night line-up. One name sure to be missing from that opening night line-up is Nazem Kadri. An unimpressive performance th...


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Hey kdogs: http://www.mlive.com/entertainment/kalamazoo/index.ssf/2010/06/lodging_options_maps_and_tips.html
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Thanks joezoo. Have a great day
Tiffany's on West Main Street and Drake Party store carries Boffo Brown. I just called Tiffany's to confirm and the employee said they have it in single bottles. Cheers.
The Goof,
The Eccentric Cafe will tap Hopslam at 11 a.m. Monday. Cases and mini kegs will be sold at the general store starting at 10 a.m.
The Merriam-Webster Dictionary defines the noun "stint" as: "a period of time spent at a particular activity." http://mw1.merriam-webster.com/dictionary/stint. Thanks for playing.
TMZ update its story, but you have to scroll down to the bottom: "UPDATE: A rep for Rodman tells TMZ they have spoken with the owners of the club, who were very cooperative and a new deal has been agreed to for the real Dennis Rodman to show up and host a party on January 28." I just got off the phone with Bill Fahl, marketing director at Reedy Corp. Inc., which owns the Entertainment District, and he said "I know for a fact, as of yesterday, it's a done deal. ... He's coming for sure."
His management is aware of it. There are also some local booking agents who have made some attempts. Thanks for reading.
Still working on it. Fair organizers say it hasn't been confirmed yet.
I just called Saree Miller, the manager of the Allegan County Fair, and she said that's not true. Kid Rock's camp has asked her not to release the artist's name. It sounds like the artist has changed several times, but it is not someone as recognizable as Crow.
No problem. Thanks for pointing it out.
My fingers must have had fruit on the brain. Fixed it. Thanks, Bryan.
You get three ounces with each token.
Thanks for bringing these new breweries to my attention. I've updated the list. Thanks again and cheers.
Phil's system: He designed a two-tiered setup with two 15 gallon pots and a 10 gallon pot, brewing 10 gallon batches. He uses a march pump to transfer the wort to his temperature regulated 14-gallon conical fermenter.
He uses all grains.
He's won awards for his Kolsch, Belgian Blonde, Light Lager, Brown Porter and Mead, among others. We didn't talk about hops.
Hope that helps.
Good call. Here is my story on Patchwork's opening:
I posted new videos with other stories on this event. In an attempt not to use the same ones, I went with an older video. I added some newer videos to this post. Enjoy.
This Saturday, Feb. 25.
Check out what NPR did this year: Beethoven's 10th?
The missing "r" has been added.


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More and more prestigious American liberal arts colleges are making it voluntary for applicants to submit standardized test scores, without, they claim, favoring students with high scores who do submit them. These institutions hardly lack for excellent applicants. What's up?
Nearly all American college applicants take either the Scholastic Assessment Test or the American College Test. The ACT is more popular in the Midwest, where most colleges that have downplayed the SAT are in the East.
The SAT gospel has always been that it provides a level playing field in which the enormous socio-economic variations among applicants can be offset, even eliminated. On this view, students rejected from prestigious institutions despite excellent high school grades, high class rankings, substantial extracurricular activities, and wonderful recommendation letters but less than stellar SAT scores have no reason to complain. Yet some leading liberal arts colleges have reconsidered this gospel.


text:
A vigil is planned for Wednesday night for the woman and three children who died Tuesday in a fire in Schuylkill County.
It comes as investigators search for the cause of the deadly blaze.
Investigators were at the scene of a fire Wednesday which claimed the lives of a woman and three children in Shenandoah.
So were friends, family and others who stopped by to mourn the loss of four who were killed.
Four row homes were destroyed by flames in Shenandoah and all day people came to a make shift memorial being built on the porch of one particular house.
They left balloons, flowers and candles.
An electronic memorial is being built on Facebook.
People are grieving the loss of Tiffany Sanchez, her son, 10-year-old Christian, and two nephews, seven-month-old Aziah and 10-year-old Damien.
"It's still not real, it's still not real. I think that I am going to see her maybe, it's not sure," said Sanchez's cousin Kathy Weikel.
"It's just very heartbreaking and I only live right around the corner here and every chance I have I come over and pray for them," said Mary Bath of Shenandoah.
According to authorities Tiffany Sanchez tried to save all of the children. She was able to get one boy, Diego Sanchez, on the porch roof. He was hospitalized from breathing in too much smoke. He has been released.
"Between her being my friend and the children, your heart goes out to everyone and I have children myself and I would do what she did. I would save my child first," said friend Charlene Davidson.
She and her friend Danielle Stetler brought flowers to the scene of the fatal fire.
"I knew Tiffany and the kids and I have a kid myself and it hit my heart and stuff," Stetler said.
The emotions are hard to shake. Terry Karpovich lost everything when his house burned.
"Everything was waking me up. I would fall asleep and I would dream about this and I would wake up crying," Karpovich said.
Some children are trying to deal with the loss.
"He started crying. Right now he's at home and my sister is dealing with the emotional pain," Davidson added.
"It shook her up. She's afraid it's going to happen to her now. Just trying to calm her down saying it was an accident," said Karpovich.
Investigators have not released the cause, but Shenandoah's police chief said it started on the first floor in the victim's home and does not appear suspicious.
The coroner has ruled the deaths of the woman and three children accidental.


text: Head Coach John Harbaugh also clarified what Castillo's role will be on the staff. As the Ravens go through their Super Bowl XLVII preparation, the coaching staff will have another voice in the room. The team hired former Philadelphia Eagles Defensive Coordinator Juan Castillo to serve as a consultant for the weeks leading up to the Super Bowl, and he will remain on staff as the run game coordinator next season. Castillo took the job with the Ravens after turning down other options.


text:
And We Wonder Why Apes Throw Feces at Us?
Categories: Animals
|Life imitates art, hanging upside down from a banana tree.
"They were posturing for the females," Julie Neemeyer, the zoo's director of marketing, told the Star. "They were doing what male gorillas do."
The escaped gorillas reportedly posed no threat to visitors to the park, but that didn't stop zoo officials from blasting the animals with water hoses to get them to return to their cages.
Fast forward to the year 3978 A.D. and Charlton Heston (below) wonders why he's treated the same way by his ape masters!? Oh, it's a madhouse! A madhouse, indeed!
Sponsor Content


text:
Video: 'Drunk' ER doc's car goes airborne
A 78-year-old man had to be taken to the hospital after the incident
Associated Press
WELLESLEY, Mass. — A one-time doctor of the year at a hospital near Boston has pleaded not guilty to driving drunk and under the influence of prescription drugs, which led to a scary crash.
Surveillance video released by police shows the car driven by Dr. Kristin Lynes Howard speeding from a supermarket parking lot, over a grassy median and onto a street, where it slammed into two other vehicles. A 78-year-old man required hospitalization.
The 56-year-old Howard was released on personal recognizance after pleading not guilty to a variety of charges Tuesday in connection Friday's crash in Wellesley.
Authorities say Howard prescribed herself drugs. Police say she told them her car had a mechanical malfunction.
Copyright 2015 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
Latest EMS Jobs


text:
This is my reply to you about surgery and herbs. I went to
the archives and copied the message.
Ma-hauang, a common herb found at health stores and quick marts etc, is a product you buy to increase you energy level or lose weight. It contains ephedra, which is a super stimulant. It is also is in some of the herbal supplements made to help cure colds and flu. It definitely dries up sinus conditions. Guarana extract is along the same line but not near as strong, it also contains caffeine. Licorice is harmless enough but it can make your body retain water. There is more but these are the ones I avoid because of elevated blood pressure.
Ginger is blood thinner, that is good for me but I'd avoid it before surgery.
St Johns Wart is an antidepressant but not to be used if one is taking an antidepressant prescribed by your doctor, I don't take either.
I have some books on herbal and alternative medicine that I use to read quite often just so I knew what was good and bad for me and notes. There stored somewhere but there are few that I take anymore.
People should know what the effects are related to their personal health. I've forgot now but as I recall there may be a couple of vitamins that shouldn't be taken before surgery.
My opinion is discontinuing anything 2 or 3 days before surgery to be safe. The Doctor or hospital should inform you of this before surgery. Usually they will say, don't take, eat or drink anything at least 12 hours before.
Do a search on a health web site, about what you take and also, what if any condition and any complications. Some people might be surprised.
Rod ~~ can climb a flag pole after Ma-hauang


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|Matthew Dillon <dillon@xxxxxxxxxxxxxxxxxxxx>
|Thu, 1 Dec 2005 11:22:50 -0800 (PST)
:Hello. :After the following commit, stopping a user process with SIGSTOP :does not give control to the shell: :http://leaf.dragonflybsd.org/mailarchive/commits/2005-11/msg00109.html :It only happens with a program which does fork() inside it. Here's :a simple program to demonstrate this. I can't reproduce this with HEAD. There was a bug in my initial commit but I did commit a followup a few days ago that should have fixed it. -Matt


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Ridge Of High Pressure Blocks Snow From Oregon Ski Resort
By Tom Goldman
Originally published on Thu January 30, 2014 5:24 am
Throughout the West, bone dry conditions are exacting a toll on places that rely on water to thrive. In southern Oregon, recreation plays an important role in the region's economy. The ongoing drought is drying up streams where fishing once was plentiful and it's left ski resorts wanting for snow.


text:
If you're anything like me, you are right at this moment sitting in your boxers, microwaving your lunch, and watching the Tiger Woods press conference on mute. And let's face it. You are a lot like me.
Because you are so much like me, you are also reluctantly visiting the TMZ website and noticing that not only are they live streaming the Tiger Woods press conference, but also LIVE STREAMING ONE OF TIGER WOODS MISTRESSES WATCHING THE PRESS CONFERENCE!
Wow, TMZ. You really nailed it. This is what technology was made for. Back when Galileo invented discovery, he knew one day we'd all watch a porn star watch a guy she slept with answer questions about golf. And finally. Here we are.


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HSA crystals are provided in the form of tetragonal plates having the space groups P421 2, the crystals being grown to sizes in excess of 0.5 mm in two dimensions and a thickness of 0.1 mm. Growth of the crystals is carried out by a hanging drop method wherein a precipitant solution containing PEG and a phosphate buffer is mixed with an HSA solution, and a droplet of mixed solution is suspended over a well of precipitant solution. Crystals grow to the desired size in 3 to 7 days. Concentration of reagents, pH and other parameters are controlled within prescribed limits. The resulting crystals exhibit a size and quality such as to allow performance of x-ray diffraction studies and enable the conduct of drug binding studies as well as genetic engineering studies.
1. An HSA crystal in the form of tetragonal plates having the space group P421 2 and the following unit cell constants: a=b=187(1)A, c=81(1).
2. A crystal as defined in claim 1 having a size of at least 0.5 mm in two dimensions and a thickness of at least 0.05 mm.
3. A crystal as defined in claim 2 having a size of 0.5×0.5×0.05 mm to 2.0×2.0×0.3 mm.
4. A crystal as defined in claim 1 having a crystal density of 1.138 g/cm3.
5. The method of growing crystals of HSA which comprises:
providing an aqueous solution of HSA at a concentration of 90 to 200 mg per ml;
providing an aqueous precipitant solution comprising PEG at a concentration of 35 to 45 volume percent and a buffer at a concentration such as to povide a pH of 4.6 to 7.2;
mixing a droplet of said HSA solution with a droplet of said precipitant solution;
suspending the resulting mixed droplet over a well of precipitant solution in a sealed container, the vapor pressure of the solution in said well being lower than in the resulting solution in the mixed droplet; and
allowing the suspended mixed droplet to stand for a prolonged period until an HSA crystal therein grows to a predetermined size.
6. The method of claim 5 wherein said buffer is monobasic potassium phosphate.
7. The method of claim 6 wherein the concentration of said buffer is 0.05 to 0.1 M.
8. The method of claim 7 wherein said precipitant solution is prepared by mixing a PEG solution with a buffer and adjusting the pH of the resulting mixed solution.
9. The method of claim 8 wherein said mixed droplet is allowed to stand for a period of 3 to 7 days.
10. The method of claim 9 wherein said mixed droplet is allowed to stand until said crystal grows to a size of 0.5×0.5×0.05 mm to 2.0×2.0×0.3 mm.
11. The method of claim 10 wherein the molecular weight of said PEG is 180 to 800.
12. The method of claim 11 wherein the average molecular weight of said PEG is about 400.
13. The method of claim 12 wherein the concentration of HSA in said aqueous solution is about 200 mg per ml.
14. The method of claim 7 wherein the pH of said precipitant solution is adjusted to a value of 6.8 to 7.2.
15. The method of claim 14 wherein said pH is adjusted to a value of 7.2.
16. The method of growing crystals of HSA which comprises:
providing an aqueous solution of HSA at a concentration of 90 to 200 mg per ml;
providing an aqueous precipitant solution comprising PEG at a concentration of 35 to 40 volume percent and a buffer at a concentration such as to provide a pH of 4.6 to 7.2;
combining said HSA solution with said precipitant solution and allowing the resulting solution to stand for a predetermined period until an HSA crystal therein grows to a predetermined size.
17. The method of claim 16 wherein said HSA solution is disposed within a semipermeable size exclusion membrane and said precipitant solution is combined with the HSA solution by diffusion through said membrane.
18. The method of claim 16 wherein said precipitant solution is combined with said HSA solution by slow addition thereto and the resulting solution is left to stand in a sealed container.
The invention described herein was made by an employee of the United States Government and may be manufactured and used by or for the government of the United states of America for governmental purposes without the payment of any royalties thereon as therefor.
This invention relates to protein crystal growth and more particularly to the preparation of crystals of human serum albumin in a form and size suitable for x-ray studies of crystal structure.
Serum albumin, a protein of multiple functions and manifold applications, is one of the most extensively studied proteins in biochemistry. Over 25,000 literature citations involving the biochemistry and/or applications of serum albumins have been published since 1969. The mammalian serum albumins proteins are known to be the product of three tandem gene duplications, and possess high helical content (60%) and high cystiene content (17 disulphides) with approximate molecular weights in the range of 65,000 daltons. Complete amino acid sequences are known for bovine, rat, and human serum albumins. Although the principal function of serum albumin remains unknown, it contributes to many transport and regulatory processes. Many studies have focused on the multifunctional binding properties of this interesting protein which range from various metals, e.g. Ca and Cu, to fatty acids, hormones, and a wide spectrum of therapeutic drugs. The majority of these binding studies have involved the human serum albumin (HSA) and many have shown that the distribution, free concentration, and metabolism of various pharmaceuticals can be significantly altered as a function of the magnitude of binding to HSA.
A detailed knowledge of the three-dimensional structure of serum albumin is imperative in order to fully understand the binding modes as well as many of the physical properties of this multifaceted protein. In addition, since many newly developed pharmaceuticals are rendered less effective by HSA; it is apparent that the crystal structure of a serum albumin, particularly the human form, will find very broad and significant application in the area of rational drug design. Consequently, the serum albumins have been the subject of ongoing crystallographic investigation which includes the documentation of several crystal forms (Table 1). Because of difficulties with crystal size, quality, and/or reproducibility, the three-dimensional structure of a serum albumin remains unknown.
This invention is concerned with the methodology required to produce a new crystal form of HSA which can be grown reproducibly as large, relatively high quality crystals suitable for x-ray structure determination. Once the three dimensional structure has been determined it will become possible to learn the molecular details involved in the binding of the albumin with a large number of pharmaceutical compounds. This may be done by soaking crystals in an appropriate stabilizing solution which contains the drug molcules of interest. If the binding sites are available in this crystal form, a crystalline array containing the serum albumin protein and the drug molecule will be produced. Details of the molecular interaction between the drug and protein can then be determined by established procedures in x-ray crystallography.
Due to the multiple binding capabilities of HSA, knowledge of its three dimensional structure combined with suitable crystals, may also provide assistance in determining the structures of various small molecules and perhaps small proteins which have proven difficult to crystallize.
Crystals of human serum albumin have been known for some time. As early as 1952, large crystals of HSA had been grown. Detailed x-ray examination of these and other reported crystal forms, including crystals of Horse serum albumin were published by McClure and Craven in 1974 (1) See Table 1, below. Crystals of HSA have also been grown by Rao and co-workers (2). Table 1 summarizes the crystallographic data published to date on several human serum albumin crystal forms. According to Peters in a recent review (1985) on serum albumins (3):
Although readily crystallized, albumin has relinquished few of its secrets through x-ray crystallography to date. . . . Structural information from these crystals is awaited eagerly, but obtaining it appears to be fraught with obstacles. Low described monoclinic crystals as soft waxy, and crystals studied by Rao, et al. (1976) have tended to dissolve under study.
TABLE 1__________________________________________________________________________CRYSTAL DATA ON THE POLYMORPHS OF HUMAN SERUM ALBUMINCrystal SystemMonoclinic Orthorhombic Orthorhombic Tetragonal Tetragonal__________________________________________________________________________Space Group C2 P21 21 21 P21 21 2 P41 21 2 P421 2 or P43 21 2Unit Cell a = 126.5(3) a = 155(1) a = 137.3(1) a = 84.0(5) a = 187(1)Dimensions b = 39.2(1) b = 83(1) b = 275(3) c = 276(3) c = 81(1) c = 135.2(3) c = 122(1) c = 58.02(2) B = 93.3(1)Unit Cell 668,900 1,570,000 2,125,000 1,947,000 2,832,000Volume A3Molecules/ 1 2 3 1 2Asymmetric UnitDiffraction 2.7 3.7 3.0 3.8 2.9Limits AMatthews 2.52 2.95 2.66 3.66 2.66Coefficient*Solvent Fraction 52% 59% 54% 67% 54%References (1) (1) (2) (1) This work__________________________________________________________________________ *Based on HSA MW 66458 References 1. R. J. McClure and B. M. Craven, J. Mol. Biol. (1974) 83, 551-555 2. Rao, S. N. et al. (1976) J. Biol. Chem., 251, 3191-3193 3. T. Peters, Advances in Protein Chemistry, Vol. 37, pg 161-243, (1985)
Crystals of the monoclinic form reported by McClure and Craven appear to be the highest quality; unfortunately, the crystals are small and difficult to reproduce. It is difficult to adequately compare the crystal quality of the remaining tetragonal crystal form with the tetragonal crystal form reported here, since the diffraction resolution reported for that crystal form was obtained with a conventional sealed tube source.
It is therefore an object of this invention to provide HSA in the form of crystals amenable to use in x-ray diffraction studies.
Another object is to provide HSA crystals having a size of at least 0.5 mm in two dimensions.
Yet another object is to provide HSA crystals in a form suitable for drug binding studies.
Still another object is to provide a method of preparing such crystals.
In accordance with the present invention human serum albumin crystals are provided in the form of tetragonal plates having the space groups P421 2. These crystals may be readily grown to a size well in excess of 0.5 mm in two dimensions and a thickness of 0.1 mm, this size enabling effective x-ray diffraction studies from which molecular configuration may be deduced. The crystals grow from solutions of polyethylene glycol, which will provide for the added advantage of solubilizing various pharmaceutical and biological compounds for binding studies. Human serum albumin is known to undergo substantial conformational change with changes in pH. This crystal form is the only one to grow under conditions of physiological pH, and therefore will provide the most relevant information with regard to drug binding studies. Crystallization conditions are reproducible, and the crystals diffract to resolutions adequate to determine the nature of the binding modes of various biological and pharmaceutical compounds. Crystals prepared in accordance with the invention may also prove useful in conduct of genetic engineering studies.
Crystal growth may be readily carried out by a "hanging-drop" method using a polyethylene glycol solution and a monobasic potassium phosphate buffering agent, with solution pH being adjusted prior to initiation of crystal growth.
Details of the invention will become apparent from the accompanying drawings wherein:
FIG. 1 is a photograph showing a crystal of HSA embodying the invention;
FIG. 2 is an x-ray precession photograph of such a crystal; and
FIG. 3 is an x-ray oscillation photograph of an HSA crystal;
FIG. 4 is a schematic drawing showing a proposed packing arrangement of HSA molecules in crystals prepared in accordance with the invention.
HSA crystals embodying the invention may be grown from a precipitant solution of polyethylene glycol (PEG), and a buffer, with concentration of reagents and pH being carefully controlled within prescribed limits. Any of the three basic techniques generally used for growth of protein crystals, that is, "hanging drop" or vapor diffusion, dialysis and batch methods may be employed, but the hanging-drop method is preferred.
In the hanging drop method a small drop of protein solution is placed on a cover slip, or glass plate, which is inverted over a well of solution and sealed. The solution in the well contains a precipitating agent, which is also present in a lesser amount in the protein droplet. The function of the precipitating agent is twofold. First, the solution in the well is initially at a lower vapor pressure than the protein droplet so that evaporation progresses at a rate fixed by the difference in the vapor pressures and the distance by which the vapor (usually water) must diffuse. Secondly, the precipitating agent lowers the solubility of the protein in solution by competing with the protein for available solvent, and thus as evaporation from the protein droplet occurs the solution becomes supersaturated in protein. Under the appropriate conditions including pH, protein concentration and temperature, crystallization of the protein or macromolecule then occurs.
The precipitant solution for use in the hanging drop method is made up to contain PEG at a molecular weight of 180 to 800, and preferably about 400 and a concentration of 35 to 45 volume percent, with best results being obtained at 40 volume percent, and a buffer in an amount sufficient to provide the required pH. Monobasic potassium phosphate at a concentration of 0.05 to 0.1M may be used for this purpose. Other buffers such as sodium acetate, sodium citrate and Tris (hydroxymethyl) aminomethane-maleate may also be used.
I have found that the pH of the precipitant solution obtained after mixing of PEG and buffer is critical to effective and reproducible growth of HSA crystals. A solution pH of 4.6 to 7.2 may be used, with best results being obtained at a pH of about 7.2. In a preferred procedure the precipitant solution pH is adjusted after mixing to compensate for variations in pH which may arise from variation in molecular weight and residue content of PEG. Adjustment of pH is readily carried out by addition of small amounts of a solution of a base such as potassium hydroxide or an acid such as hydrochloric acid until the desired value is obtained.
HSA may be provided in the form of an aqueous solution at a concentration of 90 to 200 mg per ml, with best results being obtained at 200 mg per ml. Use of HSA that is essentially free of fatty acids is preferred. In carrying out the hanging drop method a droplet of this solution, typically comprising 10 microliters, and a droplet containing an equal volume of precipitant solution would be placed on a cover slip and allowed to mix. A larger amount such as 1 ml of precipitant solution, without HSA, would be disposed in the well of the apparatus.
Crystals grow from these periods in 3 to 10 days to dimensions of 0.05×0.5×0.5 mm to 2.0×2.0×0.3 mm. The variations in the times for crystal growth are a function of protein concentration and pH. At concentrations of 200 mg per ml and pH values from 6.8 to 7.2 growth times are typically 5 days. For x-ray diffraction experiments the crystals are transferred from the hanging drop to a 10 to 20 microliter droplet of the corresponding reservoir solution, i.e. 40% PEG 400 in 0.05 M phosphate buffer. The crystals are stable in these solution at 4 C for long periods of time. The pH of this stabilizing solution may be adjusted to enhance the binding of molecules for diffraction studies, in most cases without destroying the crystals.
The dialysis method utilizes a semipermeable size exclusion membrane which retains the protein but allows smaller molecules (buffers and precipitating agents) to diffuse in and out. Essentially identical conditions to those determined for the hanging drop method (or vice versa) can then be used to grow protein crystals. In dialysis, rather than concentrating the protein and the precipitating agent by evaporation, the precipitating agent is allowed to slowly diffuse through the membrane and reduce the solubility of the protein keeping the protein concentration fixed.
The batch methods generally involve the slow addition of a precipitating agent to an aqueous solution of protein until the solution just becomes turbid, at this point the container is sealed and left undisturbed for a predetermined time.
In practice, once the appropriate precipitating agent(s) buffer(s) and other experimental variables have been determined for any given growth method, any of these methods or others unmentioned could be used to grow crystals of a given protein. Thus these features as described above for growing HSA by the hanging drop method may also be applied to growing HSA by batch or dialysis methods.
The invention is further illustrated by the following specific examples.
Crystals of HSA were grown from PEG using hanging drop procedures and apparatus. 5 μl portions of 35 to 40 percent PEG (molecular weight 400) in 0.05M KH2 PO4, pH 4.6, were added to equal portions of 120 to 180 mg/ml HSA, placed on glass cover slips inverted and sealed over wells containing 1 ml 40 percent PEG in 0.1 M KH2 PO4. Crystals appeared in 24 to 48 hours in the form of tetragonal plates and reached a size of 0.6 by 0.3 mm by 0.1 mm thick in 3 to 4 days. A photograph of one of the resulting crystals is shown in FIG. 1 of the drawings.
Crystals prepared as described above were transferred to a stabilizing solution of 35 to 40 percent PEG 400 in 0.1 M KH2 PO4 and mounted in glass capillaries. X-ray precession photographs of resulting crystals were taken on a Supper camera with a Rigaku RU200 rotating anode source. An x-ray precession photograph thus obtained is shown in FIG. 2 of the drawings.
HSA crystals were grown by the procedure of Example 1, except that the concentration of KH2 PO4 was 0.1M in the precipitant solution, and solution pH was adjusted to 6.2 prior to mixing with HSA. Oscillation photographs were taken on an Enraf-Nonius Arndt-Wanacott camera at the Brookhaven Synchrotron Light Source operating at 2.5 GeV with a beam current between 120 and 45 ma. An oscillation photograph so obtained is shown in FIG. 3 of the drawings.
X-ray procession photographs indicate 4 mm symmetry for the hko zone and mm symmetry for the hh1, h01 and 0k1 zones. The h00 and 0k0 zones show systemmatic absences for h or k=2n+1. There are no systemmatic absences along the 001 direction. The space group is therefore concluded to be P421 2. Consistent with the presence of an isotropic axis, the crystals do not extinguish polarized light when viewed down the four fold axis. Unit cell constants as measured from precession photographs were found to be a=b=187(1) and c=81(1) A. A crystal density of 1.138 g/cm3 was determined using aqueous Ficoll gradients. This value for density indicates two protomers per asymmetric unit, which corresponds to a Matthews coefficient of 2.6 Å3 /dalton and implies a solvent content of 54 percent.
FIG. 4 of the drawing illustrates a proposed orientation of the two molecules in the asymmetric unit of the P421 2 form. In this packing arrangement the shaded and unshaded molecules are related by a pseudo two-fold rotation forming a subcell with axes a'=b'=132 Å as required and possessing a molecular length of 100 Å. Packing considerations in this case appear to limit the molecular length to values of 130 Å or less and values near 100 to 110 Å seem more appropriate, although solution and electron diffraction studies estimate a molecular length of 140 Å. The subcell shown in FIG. 4 would possess P422 pseudo-symmetry and contain one molecule per asymmetric unit.
While a preferred embodiment of the invention has been described using specific terms, such description is for illustrative purposes only, and it is to be understood that changes and variations may be made without departing from the spirit or scope of the following claims.
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Aaron Gluth
B.S., Roanoke College
M.D., University of Virginia School of Medicine
Aaron's personal statement emphasizes his commitment to the medically underserved- an attribute that Emory residents need to succeed in our program. He demonstrated this commitment on his psychiatry rotation where he was described as "exceptional" and among the "top 10 students that I have taught". In fact the faculty "concluded that he would become a leader in his discipline". These same qualities were evident during his interview day.
Erika Heard
B.S., Spelman College
M.D., Duke University
Erica has a full scholarship to Spelman and was elected to the Golden Key, Mortar Board, Beta Kappa Chi, and Alpha Epsilon Delta national honor societies in recognition of her academic achievements. In college she spent a summer studying cellular pathways involved in replication of HIV and a summer at Washington University examining the effectiveness of a community intervention for sickle cell disease. She presented the latter research at the National Sickle Cell Disease Association. Erica matriculated to Duke earning the Wachovia Strickland and Davidson Council scholarships. At Duke Erica studied the mediating effects of social support on perceived stress, depression and hypertension in the African American population. This work will be published in the Journal of the National Medical Association. In the summary in her Dean's letter she was described as an exemplary student who was repeatedly commended for learning, dependability, responsiveness to feedback and interactions with patients and her teams.
Daniel Cucco
B.S., University of Maryland
M.D., State University of New York Downstate Medical Center College of Medicine
Daniel was born in Brooklyn, New York. His solid performance in medical school is a demonstration of his commitment to academic excellence. His evaluations consistently mentioned his solid clinical skills and medical knowledge as well as his reliability and work ethic. During medical school he served on the curriculum and educational policies committee as a class representative. Daniel also had the opportunity to take two electives that were not required of him, one in emergency medicine and the other in neuroscience, which he passed with honors. He also worked on gathering data for multiple clinical research projects for the department of Emergency Medicine. In his free time he enjoys working on creative projects using graphic design and film. One of his recent projects was designing t-shirts for his medical school's dodge ball team.
Vera Tate
B.S., University of Central Arkansas
M.S., University of Central Arkansas
M.D., University of Arkansas for Medical Sciences College of Medicine
My interests can be summed up in one word-disparities. I am primarily interested in improving mental health access through working with primary care physicians in rural or underserved communities. In addition I have an interest in facilitating the ongoing work to decrease the stigma associated with seeking mental health services in disadvantaged/minority populations as well as globally. So whether it is here in the States or abroad, I would like to work to close the gap and to improve access to mental health providers. In my spare time, I enjoy laughing with family and friends, writing, and traveling.
Stephanie Schmitz
B.A., Northwestern University
M.D., University of Maryland School of Medicine
While in medical school, Stephanie held numerous leadership positions that allowed her to pursue her passions for social, healthcare, and reproductive justice. Such enthusiasm was evident in the work she performed as coordinator for Medical Students for Choice and as a Spanish Interpreter for Healthcare for the Homeless and abroad. She was also elected President of her school's Alpha Omega Alpha Chapter and is a member of the Gold Humanism Honor Society. When outside the hospital, she spends much of her free time indulging in her love of travel, good food, and dance. Stephanie went to India during her 4th year of medical school and hopes to continue traveling abroad at least once a year, if only for the chance to try new cuisines. She has been an avid salsa dancer for over 7 years, and occasionally dabbles in swing and tango.
Marsha Stern
B.S., Tulane University
M.P.H., Tulane University School of Medicine
M.D., Tulane University School of Medicine
Marsha graduated from Tulane University, where she was a varsity rower. As an undergraduate, Marsha received departmental honors and the Ann Royal Arthur Memorial Award in German. While in medical school, Marsha also pursued a Masters of Public Health in Epidemiology. Her MPH project dealt with prostate specific antigen screening and mortality. She hopes to study quality improvement measures in the future. Marsha has been a member of the MD/MPH executive committee and the Owl Club, a student group that evaluates and rewards teaching at Tulane. In her spare time, she enjoys running, traveling, and spending time with friends and family.
Jonathan Kaplan
B.S., University of Illinois at Urbana-Champaign
M.D., Rush Medical College of Rush University Medical Center
Jon was selected to serve as a member as one of five Rush Medical College representatives to the Chicago Department of Public Health student committee, with the charge of improving public health in the city of Chicago. He was also nominated for membership in the Gold Humanism Honor Society by his graduating class for his exceptional service to the community. He completed a sub-internship on the inpatient unit at Emory Hospital and impressed the attendings with his medical knowledge, work ethic, dependability, and self-directed learning. His hobbies include endurance races, flag football, volleyball, and travel.
Stefan Routt
B.S., Butler University
M.S., Indiana University Purdue University Indiana
M.D., Indiana University School of Medicine
Following graduation from Butler University, Stefan went on to earn a Masters Degree in Biology from IUPUI. Stefan spent three summers working in a laboratory as a research associate, focused on studying metalloenediynes as possible sensitizers to radiation. The work resulted in a first author publication in the International Journal of Hyperthermia. His Dean's letter comments on a number of impressive qualities, including the eagerness to learn, strong team orientation, and the willingness to do the hard work needed to take the best care of the patient. During the clinical years of medical school, Stefan discovered his passion for working with patients with mental illness. He especially enjoys the challenge of providing compassionate and quality inpatient care for those with multiple medical comorbidities and would like to work to reduce the disparities in medical care that many patients with mental illness experience. Outside of school activities, he enjoys spending time with his family and friends, playing basketball, painting, and drawing.


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|30 posts found
Associate Editor - News Manager
Joined: 6/28/10
In our latest look at all things Final Fantasy XIV: A Realm Reborn, we check out what the crafting and harvesting systems will be like for players. Find out more about the two and then leave your thoughts in the comments.
Read more of Ryahl Smith's Final Fantasy XIV: A Realm Reborn - Crafting and Harvesting in FFXIV.
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Elite Member
Joined: 8/21/04
Logic be damned!
My only worry is that people are not going to use the markets enough to minimize the need for every crafter to level up a multitude of classes instead of just focusing on say one primary gathering class and an associated crafting class.
Couple that with cross-class skills to make life easier and crafting easier/more efficient, and any serious crafter is going to have to level multiple disciplines.
Which I guess isn't a bad thing, as once you hit level 10 and do the quest you don't have to do ANY combat anymore if you choose to focus 100% on crafting, which is nice.
What I'd like to see though is an addition to the Duty Finder system for crafters - it'd be SO nice to have an easy way to find local crafters capable of melding Materia into items.
As I understand it, everyone crafter or not gets the ability to break items down into Materia, but only the crafter can meld it?
It'd be so, so nice to be able to use the Duty finder to find an appropriate level crafter to do the Meld instead of having to spam chat channels (or just in guild etc.)
It is a fun and interesting system. Dungeons + crafting/gathering is going to be the primary focus of my next play sessions before the wipe.
I don't want to advance the stories or classes too much further on a throw away character, so time to switch gears and really delve deep into crafting/gathering! (after a trial dungeon run or two)
I've probably been lurking for way, way too long.
Defender of Worlds
Joined: 5/20/04
I actually still like MMORPGs
Originally posted by BadSpock
I've never been much of a crafter. So I know myself personally I might focus on gathering skills alone and sell to the crafters.
I just wish if you wanted something made you actually had fo travel to the crafting location and just ask in open chat /s can someone make me an offer on crafting x item? It would be an open air market, but at least you get some real facetime with other players. They are serving a purpose and everyones building rep with each other. We have enough instant gratification going on already. I like making my own gear, but I know I cant keep up with the best crafters. I enjoy seeing iconic players in the games though. The ones you recognize a year later if you hadnt seen them in a while. I think ff arr has the potential to create those " in game celebs" that you see from time to time and just cant help curiously examining thier habits and or perhaps sparking up a conversation and gaining an opportunity to pick thier brains a while and see what perspective theyare coming from.
Apprentice Member
Joined: 1/24/04
Hell is other people. - Sartre
Originally posted by Battlerock
There's nothing STOPPING players from doing this to avoid AH fees etc.
There is NO reason to force people to have inconvenience, though. The AH addresses a multitude of problems, whether it's a crafter that plays at off-times so they wouldn't have anyone to sell to or just the fact that it actually gives a more fair economy based on more competition. I really wish players like you would stop trying to FORCE interaction because you think the old clunky games were the best.
Take off your rose colored glasses and realize that the reason we all spoke to each other so much was to actually figure out NEW things. MMORPGs were BRAND NEW, pulling a mob back to the group was new, knowing which ones would call friends for help was new, it was all new and therefore communication was needed. It's not new anymore, we all know what to expect and can do it without communication and adding in something that's inconvenient just for the sake of "trying to create community" just makes it so that people will harbor resentment for a poorly designed system.
Advanced Member
Joined: 11/10/05
My main concern is longevity and relevance. All it takes in these themeparks is one new raid or dungeon and crafted gear becomes nothing more than a temporary stepping stone. Another unfortunate thing that seems to happen a lot with themepark crafting is that end game materials and recipes are only available via end game raids. As a crafter, I don't want to have to raid in order to craft the best items. I don't mind as long as the materials and recipes are not soul bound. But in my experience, the best always are.
Apprentice Member
Joined: 4/15/06
Your chararacter gains experience and levels up, defining a role playing game.
Leveling is so fast that i dont really see crafting usefull. Crafting make same gears that u find from vendors. crafting is also very slow and tis type crafting seen in EQ2.
Also game is so easy that its dont matter will u have 4 str more as dps.
Apprentice Member
Joined: 12/10/12
Catapultam habeo. Nisi pecuniam omnem mihi dabis, ad caput tuum saxum immane mittam.
Originally posted by Foomerang
A good crafting consignment system, as in EQ2, fixes the problem you reference (bolded). FFXIV should have a form of consignment crafting for materia melding and repairs (they did in FFXIV 1.0), so they do seem to recognize a need for crafters who aren't raiders.
Advanced Member
Joined: 11/10/05
Id like to just play this game as a relevant crafter, get a house, hang out at the golden saucer, roleplay etc, hopefully they add a tcg. Thats the kind of mmo Ive been craving. Its difficult to find that in a themepark. This game seems to want to go down that road. We will see i guess.
Novice Member
Joined: 8/02/04
Though I found the gathering and crafting a very fun experience to gather mats and craft HQ items, I did find the gathering portion a bit mind numbing, as you run around to basically 3 or 4 nodes in a circle and gather the item with 5 swings of the ave or scythe. Yes, you can switch up which items you are getting, but other than the specific material or shard you are gathering there is no real need to, though higher level items do give you a bit more exp. After an hour or so of gathering I just had to swap over to something else of go insane.
I really do like the crafting side of things, and balancing the quality of the item, and the chance to get a HQ item with the durability. Having the Mastery skill to bring back some of the Durability is good, but it really eats your CP to use it.
In all, I think it is a solid system, and like 1.0 I think the crafters will like it better than the last system.
Apprentice Member
Joined: 12/01/05
So the crafting system is lifted straight from EQ2? Or did I miss something?
"When people don't know much about something, they tend to fill in the blanks the way they want them to be filled in. They are almost always disappointed." - Will Wright
Advanced Member
Joined: 9/18/04
Anyone who has ever played a total theme park game will tell you two things about crafting.
-Because of the loot-as-reward mentality of the actual combat part of the game, those items will always be much better than crafted items, thus making anything crafted worthless.
-Because of the insane leveling pace, whatever you make you will out level in a matter or hours.
Does anyone actually use any of the crafted gear in FFXIV? The 1.0 system was messed up, but I used crafted stuff because the loot rewards were actually the same thing.
I think what will be useful will be the consumable stuff like food or potions. Everything else will be not wanted or needed or just a waste of time.
Advanced Member
Joined: 12/11/08
Originally posted by Kniknax
Not exactly, but its very similar to a mix of EQ2 and Vanguard crafting. Both of which I thoroughly enjoyed.
I just managed to do my lvl 10 class quest before beta closed on Sunday, so will be giving the system a good looking at this Friday... I've had a look at some youtube vids to get a good idea of how it fits together. If you go looking for them just make sure you're not watching a vid from before the re-make...
Novice Member
Joined: 11/20/11
In my beta testings, i went crafter quite abit to high 20s, it gets harder when aiming for high quality while trying to succeed. Also 75% of my wares did sell in AH when i put them up, mostly MRD, CNJ weps lvl 16+, you can start making armor and weps above vendors at around lvl 14-17 crafters.
Plus Not many games allow you to mine/harvest items that YOU CHOOSE. Most of the time, the node just gives you random stuff. Plus, HQ materials are VERY useful when trying to lvl crafting because quality determines the EXP Bonuses, also harvesting/mining HQ gives a huge boost to exp to gatherers(30 exp normally would go up to 250 exp per HQ depending on lvl of the node).
Novice Member
Joined: 10/13/05
I found crafting and gathering to be fun and rewarding in FF14. Go me!
As for dungeon loot being better, Im not sure right now. I stopped at level 12 THM to get a bit of crafting and ran out of time to get more levels to do a dungeon.
Apprentice Member
Joined: 12/10/12
Catapultam habeo. Nisi pecuniam omnem mihi dabis, ad caput tuum saxum immane mittam.
If I were to hammer out a HQ crafted item and take the time to materia it up, it would easily keep pace with pink-tier (sub-boss) dungeon loot. It might even hold its own against green-tier (boss loot) dungeon loot of the same level range.
There's also a ton of randomness to dungeon drops. Specifically in a game with seven classes (soon to be eight), each with a unique weapon, getting the gear you want from a dungeon is very hit or miss. My Gladiator leveled from 15-26 primarily in dungeons. I then took the auto-promote to 29 (beta-3 feature only) to do Haukke Manor. End result, I'm still sporting some green-tier level 17 items from back in Tam Tara Deepcroft. I've seen tons of dungeon drops, for other classes.
I need to invest some time this next session and push for some HQ armor to replace some of my weaker slots of gear. HQ combines are hard, but they get a lot easier when you use HQ inputs. HQ inputs (ingots, rivets, and plates) are a lot easier when you have HQ raw materials (ore, leather, etc.)
I also need to finish doing some "blow through" gearing to soulbind and convert to materia for my HQ crafted gear. I had done that for a short while with shields, make myself a couple of disposable shields, run a few dungeons, break them down for Materia. That's largely where my stock came for testing out the Advanced Materia system at level 25 crafting.
Oh, and it turns out that at level 15, crafters get cross-class abilities just like other classes do. Each class gets a unique level 15 ability, which you can cross-class once you level up another crafter. This fleshes out the variety of things you can do as a crafter.
Basically, every time you think you have this system totally nailed down they give you a new layer of complexity.
Elite Member
Joined: 8/21/04
Logic be damned!
Originally posted by Ryahl
But I thought FFXIV was just a WoW-clone money grab?
This kind of crafting in a themepark is such a welcome change. I just hope the demand for high level crafters and their wears (and materia melding ability) keep them relevant compared to raid/dungeon gear.
Not that I plan to really be a high level crafter, but I think having them and making them important is a vital part of in-game community and economy.
I've probably been lurking for way, way too long.
Apprentice Member
Joined: 12/10/12
Catapultam habeo. Nisi pecuniam omnem mihi dabis, ad caput tuum saxum immane mittam.
Originally posted by BadSpock
One thing that worries me about FFXIV is that it is very easy to come away with exactly that perception in the first few levels of the game (and I know your comment is tongue in cheek). Make no mistake, I think it's absolutely an incorrect perception, but I can see where someone would mistakenly assume that.
The layers start getting added, but sometimes very subtly, and you don't realize it's gotten more complicated until you think back on the process. Most people either (a) don't wait for the layers to show up or (b) never think back on the process and thus come to the conclusion you made (tongue in cheek, of course).
As an example, consider Guildhest. These are 4-person quick adventures (30-minute timer, you will usually finish them in half that). The first pair (level 10) introduce very basic group mechanics. If that's your sample, its easy to conclude "ho-hum, so easy" if you're an experienced MMO player.
Having finished the level 25 guildhests (they come in a pair of two every five levels), those were fun and harken back to some of my favorite old-school MMO fights. In the first level 25-guildhest, you get waves of adds. These adds can mez the tank and really disrupt the party. You need to use some crowd control and really coordinate your team through five packs of this stuff while handling a boss. The second level 25-guildhest helps to use crowd control, but its doable without it. The final fight, though, has tons of ground effects. I'm reminded of a supervillain from "the Tick," the Mad Bomber (what bombs at midnight). You spend a good bit of time in that fight shifting positions, poorly choosing where to move can leave you stranded later on. Again, for experienced players, you recognize what you're up against and start reacting to it reflexively, but (a) for new players that's going to be a shocker and (b) even for experienced players you have to admit it really ratchets the bar up from the 10 and 15 guildhest.
If you bailed on Guildhest at level 10 because "ho-hum," you missed it completely. Looking back, it's very clear that the complexity was rising in each five-level increment, but it isn't noticeable until you compare across a larger sample.
Novice Member
Joined: 10/16/07
I think it's a great system, very deep and overall just really fun. Even if the gear isn't the most desirable in the game (which we don't really know how it will feel end game) the materia system will keep crafters relevant always. It's awesome! Plus there has been talks of patterns possibly dropping from end game content/obtainable through doing end game content being added in some way later on. Will be cool to wait and see.
Hard Core Member
Joined: 3/31/12
I have thoroughly enjoyed the crafting system so far, and the fact that I can actually spend quality game time on leveling a character class to help support my main character is very refreshing to me. In the past you created multiple characters because you had crafting skill limits so you would create a new character and grind level him so that he would be another useful crafter, I don't miss those days at all. All of the interaction and experiences they have created to help with crafting and leveling seem to be a lot of fun and a mixture of different MMO styles.
It would be refreshing to be able to craft gear that was comparable to raid or high level dungeon gear, of course I would hope you would have to work a little to get the required materials to craft these items or else there would be no reason to ever experience that part of the game more than once or twice. But it would definitely help create a strong economy for players that wanted to put in the effort to craft quality items.
I am also interested to see how the system will unfold.


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Why We Made this
The pointelle and ladder-stitch patterns of this new cable knit cardigan are interesting and fresh. But you'll probably first notice how lightweight and comfortable it is. Made from 100% quality cotton yarns, it's ideal for the summer months--after a swim or around town with jeans or a dress after the sun goes down. Wear it belted or fly away--either way, its fitted style will flatter. And at this attractive price, you might want to keep a couple handy for all occasions. Imported. Machine wash. Relaxed fit, falls below hip.
Fabrics & Features
Fit & Function
Relaxed fit for a loose drape; Falls below hip
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Order Curtains, Blinds & Parts Online
Our online store is rapidly becoming the #1 Australian online source for curtain and blind parts and accessories, readymade curtains, cushions and more.
We a range of cheap and simple shipping for small orders, or if you're in the ACT / Queanbeyan region you can collect your order from our Fyshwick showroom if you prefer. We can also ship small orders (parts and accessories) to New Zealand and the United States at highly competitive prices.
Of course everything purchased from our online store comes with the same warranty and quality guarantees that we've been offering in-store since 1977.
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I currently lecture at Colchester School of Art, London College of Communication and University of Brighton.
I hold a PGCE with Distinction from University of Essex; an MA with Distinction in Design Writing Criticism from London College of Communication, University of the Arts London and a first class BA Honours degree in Visual Communication Design from Ravensbourne (validated by the Royal College of Art).
Freshly squeezed: WD+RU Postcard


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Kissimmee, FL (Sports Network) - Collin Cowgill hit a two-run home run to help the New York Mets take a 7-5 win over the Houston Astros in spring training play on Wednesday.
Matthew den Dekker drove in two runs while Jordany Valdespin added a pair of hits along with an RBI and a run scored for the Mets. Dillon Gee was tagged for five runs on seven hits over four innings of work.
Carlos Pena smacked a two-run home run and drove in three and J.D. Martinez had two hits and a run scored for the Astros. Alex White gave up three runs on seven hits over 4 1/3 innings.
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Major changes are on their way. Don't bother trying to fight them. The forces at work are far too strong for you to stand against them. And why would you want to when they are in your favor?
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Universal Orlando
Foundation Library
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Orlando, FL 32819
Ph.: 407-903-8100
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Rosen Research Guides
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Nestled in the heart of Mount Vernon, Ohio, America's Hometown, this remarkable High Victorian mansion, Circa 1830. It is home to the fifth generation
Find great deals on quality Mount Vernon, Ohio hotels & resorts, or indulge at one of our luxury resorts. Take advantage of the many amenities that can be included with your stay such as in-room internet access, wifi, room service, fitness center, pool, hot tub, steam room, and shuttle services to and from the airport. Browse our Mount Vernon, Ohio hotels and resorts and plan your Mount Vernon, Ohio vacation today!


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Topic: Yucatan Restaurants
Print this Page Email & Share
Type: Lebanese food to go
Neighborhood: Fraccionamiento Campestre
Telephone: 944-8158, 944-8286
Address: Calle 9 #278b entre 38 y 40
How to Get There from the Centro: Take Paseo de Montejo up to the Burger King circle and go to your left at this glorieta on to Circuito Colonias and continue to Avenida Campestre. Turn right on to Avenida Campestre at the signal. Continue north to Calle 7. Take a left turn on to Calle 7. Continue until you reach the end of the street where it will cross with Calle 40 (which is a two-way street). Make a quick right and cross over Calle 40 and then make a quick left turn onto the first street on your left which is Calle 9. S'mir is on the left. It's a yellow building with parking in front in a carport.
Parking: Yes
Air Conditioned: Yes
Outdoors: No
Drinks: No alcohol.
Payment: Cash only
Wifi: N/A
Hours: Daily, 7:30 AM to 4:00 PM.
Notes: S'mir is a full-service deli stocked full of Arabe (Lebanese) freshly-made and ready-to-go food products available for take-out only. All of their products are made in-house and you can even watch the production line in action through the glass wall behind the service counter. From numerous dips, kibis, stuffed grape leaves, freshly made Arabian breads, labne, Lebanese salads and meat kebabs (alambres) to sweets like date pies, S'mir offers a broad selection of locally prepared Lebanese botanas. We can attest to the fact that S'mir food is delicious and has been for years… one of Merida's best-kept secrets (until now, of course). The food is consistently fresh and tasty.
A few of their freshly made products that we especially love include:
- Date pie
- Stuffed grape leaves
- Tabouli
- Chicken soup (Their chicken soup with rice comes in two separate plastic containers. One has the liquid soup, the other is full of rice with chunks of chicken, pine nuts and other goodies. Heat up the liquid, pour in the rice concoction and prepare to get better, no matter what ails you!)
- Xcatic dip (the Chipotle dip is also delicious)
- Berenjena (Eggplant)
- Alambre (Grilled meat Brocheta)
- Freshly made Arabe bread (as well as chips made from the same bread)


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Please select a rent timeAdd To Cart +
Photoflex Pro-Duty Backdrop Support Kit
7 Days
Retail: $233.95From $20.00
- Product Details
The Photoflex ProDuty BackDrop Support Kit includes a BackDrop Pole, two LiteStands, and a rugged carry bag to hold the whole kit. This kit extends to 12' high allowing you to shoot your model from low angles without seeing the top of the backdrop. The kit can hold a maximum of 40 pounds and the kit weighs 17 pounds. The pole stores collapsed at 4'7 and extends to 12'6.


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Harbour House Restaurant in Winnetka is a hidden treasure
Before leaving Chicago for an extended stay in the Bay Area I was told I MUST visit the American Grilled Cheese Kitchen in San Francisco
Head to Highland Park, Illinois on May 27th for Art wear unlimited where you will find unique and original clothing, jewelry, accessories and special Mother's Day and graduation gifts
Growing Home is an example of some of the best in Chicago, people working together to make lives better
At 62, I seem to have fallen into a demographic no-woman's land
A visit to the Concannon Vineyard yielded great wine tasting, fascinating stories and the chance to see a winery that is "preserving the past and embracing the future"
With humor that had many bent over with laughter and pathos that brought one nearly to tears, in just over an hour, many of life's lessons were powerfully revealed in this production of "A Life in the Theatre"
The lure of NY "all dressed up" and the long President?s Day weekend was too much to resist...
The InterContinental Hotel Chicago was our perfect "staycation" destination
One wonderful night at the newly renovated Ritz-Carlton Chicago, a Four Seasons Hotel, was refreshing and renewing
When I heard about Megabus.com, it sounded like a great way to travel to my family in Detroit, and I am delighted to say it was
Hawthorn Suites Livermore Wine Country offers a "Manager's Special" so special, we had to take advantage of it - and we are so glad we did
The Embassy Suites Hotel Detroit-Southfield is well located and offers comfort to business and leisure travelers
The Hotel Monaco San Francisco is a wonderful place to stay
The Palmer House Hilton is the longest continually operated hotel in North America. Located in the heart of Chicago, one can easily walk to many tourist destinations
SpringHill Suites Southfield Detroit by Marriott proved to be a perfect place for our retreat
Experience Lazy Cloud and leave refreshed and reconnected
"Shutters at the Beach" is a wonderful place to celebrate Hannukah and a 92nd birthday.
Susie Fine, who is developmentally disabled visits Chicago's Field Museum exhibit of "Pompeii: Stories from an Eruption".
"Rumi" restaurant with rustic American and Mediterranean flavors is a "hidden gem" in San Carlos
Smuin Ballet is a new experience, unlike other companies I have seen, a unique blend of dance
The chance to see Puccini's "La Fanciulla del West", at the Lyric Opera of Chicago celebrating it 100th year is an opportunity not to be missed
Edward Albee's "Who's Afraid of Virginia Woolf?" is a masterful production with amazing performances by Tracy Letts along with Amy Morton, Carrie Coon and Madison Dirks
There's a feeling of spring watching Gilbert and Sullivan's "The Mikado", a must see new production at Lyric Opera of Chicago
Graham Greene's "Travels With My Aunt" is a brilliant production, captivating and original
In Hubbard Street Dance Chicago 2010 Winter Series there is something for everyone
I was inspired to visit Healthy Green Goods in Evanston after I heard a panel discussion about toxic environments at the Wilmette Public Library
What an amazing gift is Great Smoky Mountains National Park to our country and how impressive was the wisdom and sacrifice of the early settlers to this area
"A Masked Ball", Guiseppe Verdi's opera that tells of love, betrayal and murder is inspired by an historical event that took place in 1792 when a Swedish count shot the king of Sweden. The Lyric Opera of Chicago's production is traditional, beautiful and powerful


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Angry Apple makes hollow threat to bar Kindle, other ebook apps...
This is well worth the read . . . .
Angry Apple makes hollow threat to bar Kindle, other ebook apps.
Very interesting article. Personally, I side with Apple on this.
I'm completely against them on it. Why do they demand a royalty for ebooks and not other goods? Why should they be entitled to a 30% cut? They aren't hosting the content. They aren't processing the payment. And with their collusion with the publishers to switch everyone to the "agency" model, in combination with their "most favored nation" clause, demanding 30% of someone else's sales would mean zero profit margin for the others. Their "philosophy" is overly simplistic and quite frankly abusive. If they really want to kick Kindle and other ereader apps off, that would be a very hostile move and unfriendly to their customers, many who bought an iPad so they can enjoy content from a variety of sources.
Instead of being faced by bully boy tactics I bought a Nexus Android with a Kindle App, no problem! However Google could start getting heavy handed with Amazon!!!! I think all these companies are getting too big for their boots, remember what happened to Ma Bell ?
Agree with lifeisabeach. Such a decision would only serve to cement my decision to stay with a Kindle or Android tablet. It would push me toward an Android phone in lieu of iOS and possibly back to Windows (or give Linux another go) with my next computer purchase.
If Microsoft had hatched a plan with the introduction of Win 3.1 or Win95 that afforded them a 30% cut of everything that could be sold to work and run in Windows, MS would not exist today.
This feeling that they deserve a 30% cut of everyone else's work because they created the operating system is, as far as I am concerned, the height of greed.
So much for letting the market decide what it will bear. Why does everyone feel the government needs to regulate the private sector economy? What happened to a free market?
As I am heavily invested in Amazon media (mostly Kindle eBooks) any move to prevent me accessing it on my iPad would cause me to exercise my free-market choice to switch to another platform.
No, AT&T is not Ma Bell. Ma Bell took care of everything from the user's hand to the user's hand on the other end...house wiring, local service, long distance, etc, etc. AT&T of today isn't that end-to-end.
McDonalds' suggested budget for employees shows just how impossible it is to get by on minimum wage | Death and Taxes
In the "free" market, there'd be no minimum wage. And I GUARANTEE YOU low income workers would be making even less. Look at that comedy of a "budget" McDonalds has laid out for their workers. There is no way to make ends meet. None. Which means government assistance is required for these people to survive. How do you like the notion that your goods and services are subsidized by your tax dollars because the workers bringing them can't survive on what they make? It'd be even worse if they made $3/hour in the "free" market.
AT&T What? Customer service? hahahahahaha. Are you kidding! :D Many times now I had to do their troubleshooting for them!
My issue with going back to windows is and I don't care what anyone says, Windows 8 is not a good desktop OS. But 8.1 has a Start menu! Does it? I have 8.1. It brings up Metro. That is not the Start menu. People are mad.
I need adobe. The Gimp for me is not even close so Linux is out for my overall use. I could use it for the internet though.
Apple is getting greedy for sure and going a different way lately than they should have gone. Not sure what to do if this continues which have a feeling it will.
I wholeheartedly agree that a truly free market wouldn't work in today's society. My wife and I just had a long discussion on that exact thing about a month ago, and I was using all the same argument points you currently are (yes, I was arguing against an unregulated economy). I'm well aware of the need for some restrictions on businesses, and some minimum requirements for employees; However, the more I see the government telling businesses how to run their businesses the more upset I get. "Some" restrictions is very different than mandating exactly how a business can practice, which is the point I was getting at.
Regulating the actions of groups that are heavily invested in the social good (as banks are) is never a bad thing. And let's not forget the flip side to your argument - the governments were regulating financial institutions when the economy was strong. True, they may have been able to make more but really, there's something to be said for consistency in financial markets and not "let's hope for the best" that comes with ruthless deregulation. You can also enjoy regulation while being free - Canada's economy is heavily regulated in comparison and it is, by some measures, freer (whatever this means) than the American economy (source).
A minor point - the credit rating of the government is wholly exclusive of their regulatory practices. One is about managing their own money (credit rating) and the other is about regulating the spending of other people's money (regulations). The former was significantly hurt by the inability of some groups to regulate their own practices and not an intrinsic fault.
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6 a.m.
NBCSN LIVE: mens basketball, quarterfinals; SAME-DAY TAPE: womens boxing, semifinals; womens field hockey, semifinal; LIVE: mens handball, quarterfinals; mens table tennis, team bronze medal
9 a.m.
MSNBC LIVE: mens volleyball, quarterfinals; mens water polo, quarterfinal; SAME-DAY TAPE: womens wrestling, finals; mens table tennis, final
NBC BASKETBALL Mens, quarterfinals
TELEMUNDO Mens basketball, quarterfinals; track and field; mens volleyball, quarterfinals; womens beach volleyball, bronze medal
10 a.m.
NBC SAME-DAY TAPE: track and field; LIVE: mens water polo, quarterfinal; mens cycling, BMX; SAME-DAY TAPE: equestrian, individual jumping final; LIVE: womens beach volleyball, bronze medal; SAME-DAY TAPE: canoeing, sprint finals
5 p.m.
CNBC Boxing, quarterfinals
8 p.m.
NBC Track and field, finals: mens 110 hurdles, womens 200, womens 400 hurdles, womens long jump; womens diving, platform; womens beach volleyball, final Midnight
TELEMUNDO Track and field, finals; womens diving, platform; womens beach volleyball, final
12:05 a.m.
NBC DELAYED TAPE: track and field; LIVE: womens cycling
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MG B Cabriolet 1979 fully original 15.400 miles from new Fully original, very good condition, 1979 MGB Cabriolet. 2 owners car, the last one since... More
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1955 MG TF '55 MG TF with matching numbers in British racing green with green interior. Comes with the soft top, side curtains, rear luggage... More
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Although the new design of the MGA which took the place of the TD-body cars dates back to 1951, it was not produced until... More
MGB Roadster 1974 overdrive body off restored This 1974 MGB convertible is fully restored by us in 2014 and is in top condition because of... More
1971 MGB Roadster O/D This is an extremely clean, rust free and accident free MG Delivered new in California. Excellent engine and... More
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Not your everyday MG B here. This version comes complete with a well installed and sorted Chevrolet 355CI V-8, Edelbrock intake, Holley 750, Ford 9"... More
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1947 MG TC BARN FIND VIN TC5414 RED EXTERIOR BLACK INTERIOR VOLVO PV544 4 CYL. ENGINE 4 SPEED MANUAL TRANSMISSION 19 WIRE WHEELS ODO... More
1949 MG TC '49 MG TC Roadster with matching numbers in red with black interior. Very original survivor. Comes with a soft top, side curtains... More
1983 MG Kit Car Convertible. The best of both worlds--a modern VW engine and chassis mated to a vintage MG style. About Motorland For sale or... More


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Jimmy Choo shoes are in Italian sizing
Step out in lady like style with these demure timeless pumps; the square toe and mod-block heel design is finished with an understated gold logo plaque. Heel measures 35mm/1.4
US Standard FREE
(2-7 working days, NY 2-3)
US Express $20 (1-3 working days, NY 1-2)
New York same day $25
(order by 2pm EST)
Canada $20 (1-3 working days)
Americas $30 (2-7 working days)
Please note; the above delivery times exclude pre-orders and made-to-order items.
Shop with confidence with free returns.
See full delivery and returns information.
Email Customer Care
or call us on (toll free):+1 877 955 2466
Italian sizing. Fits true to size. View Size Guide


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Domestic transporting
We work all 50 states.
International shipping
We deliver vehicles to every corner of the United States.
Tough, Tricky jobs
We have the perfect vehicle for one-of-kind jobs.
Our reach extends to everywhere you do business
Our team is a global one that's experienced in shipping all over the world.
Repossession Company
Our company promises each and every vehicle will be transported to each desired location with out a single scratch on every vehicle we pick up.
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We recently updated and expanded our website. Whatever it is you're looking for, you should be able to locate it more easily than ever before. If you don't find what you need, please call.
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Contrast the plans of Congress to give up on job creation and move expeditiously to deficit reduction with the plans of the Federal Reserve to belatedly but nonetheless insistently and with near-unanimous participation engage in the monetary tools at their disposal to boost the economy and lower unemployment. There are serious questions about the beneficiaries of QE3 – banks look to be one winner – and I don't think they are being terribly imaginative in their effort. But this speech by Ben Bernanke in Indianapolis yesterday did make a couple salient points that show that he understands the nature of the problem to some degree.
First, here's how Bernanke explains the "communications channel."
In the category of communications policy, we also extended our estimate of how long we expect to keep the short-term interest rate at exceptionally low levels to at least mid-2015. That doesn't mean that we expect the economy to be weak through 2015. Rather, our message was that, so long as price stability is preserved, we will take care not to raise rates prematurely. Specifically, we expect that a highly accommodative stance of monetary policy will remain appropriate for a considerable time after the economy strengthens. We hope that, by clarifying our expectations about future policy, we can provide individuals, families, businesses, and financial markets greater confidence about the Federal Reserve's commitment to promoting a sustainable recovery and that, as a result, they will become more willing to invest, hire and spend.
He's saying that interest rates will be low enough for a certain period, even if the economy improves, so people can make their purchasing decisions accordingly, without having to wait to figure out when the Fed will take away the punch bowl. That could definitely have economic implications, especially with interest rates this low. And, it implicitly acknowledges, as he says later, that "the economy is not making full use of its resources" and that monetary policy can alleviate that.
Next, Bernanke dispelled a number of myths about fiscal and monetary policy. He said that he does not keep interest rates low to induce Congressional borrowing, nor does he keep those rates higher to induce austerity budgeting. "Using monetary policy to try to influence the political debate on the budget would be highly inappropriate," he said specifically, which is the exact opposite of what, say, the European Central Bank is doing, resisting a purchase of sovereign debt until the affected countries submit to "conditions."
In fact, Bernanke said that the deficit, the main preoccupation in Washington, is a long-term issue and not one we face immediately. In particular, Bernanke said, "They (Congress) must find ways to put the federal budget on a sustainable path, but not so abruptly as to endanger the economic recovery in the near term." That's obviously not spectacular, but it's an improvement over some past rhetoric, and certainly over the "sky is falling" talk we normally hear in Washington. Further, Bernanke said of the fiscal slope that, in the event of Congressional action, "According to the Congressional Budget Office and virtually all other experts, if that were allowed to occur, it would likely throw the economy back into recession." As the fiscal slope is basically an immediate deficit reduction program, it shows Bernanke as an anti-austerity figure in Washington.
Obviously I don't agree with every piece of this speech – Bernanke lauded the new transparency he brought to the Fed as a way to rebut the desire for an audit of the institution – but on the economics, it's pretty good.


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Steakcraft: Lessons and Observations From a Year in Steak
What did 2013 show us in the world of premium steak? Longer aging times, more rib steaks, and there's more than one right way to cook a piece of beef. More
What did 2013 show us in the world of premium steak? Longer aging times, more rib steaks, and there's more than one right way to cook a piece of beef. More
Consider these books the cream of the Bake the Book crop—each one is a pleasure to page through, a delight to cook from, and comes with its own engaging story. More
When you eat out as much as I do, summing up a year of eating is excruciatingly difficult. It's one of those "tough jobs, but someone has to do it." So here goes: a baker's dozen of things that made my 2013. More
One thing is certain, we didn't skip dessert in 2013. Here are our favorite sweet bites from the past year. More
No matter how much I think I have the dining scene figured out, there is always more to find. I can't wait to get back to work in 2014, but here are the dishes that genuinely excited me in 2013. More
In a cruel, paradoxical twist of fate, I've eaten so many memorable meals this year that I can't help but feel I'm forgetting several that deserve to top this list. Alas, such is the life of a food writer in a city as rich with phenomenal dining options as New York. Many of the meals that have stuck with me are those I return to again and again; some because they're truly one of a kind, some for their unparalleled level of execution. See my top ten after the jump! More
Among the thousands of cookies I've baked this year, which stick in my mind most? These nutty, gooey, chunky, dunkable treats. More
instead of dealing with abstract concepts of "the best" or "our favorite," this list is based on cold hard facts. There's no room for the vague here, just the posts ranked by most visitors, thank you very much. More
What did I learn over this year of making breakfast sweets? A muffin's fine, but it's nice to get out of bed when there's something truly special to look forward to. More
What happened in Serious Eats land this year? Mr. Bear! Painful taste tests! Exciting birthdays! Too many doughnuts! Candy dip! Happy Yuba! Sleeping Hambone! And more! Check it all out in the slideshow » More
After a year of interviewing chefs in New York, we've heard our share of touching sound bites. Here are 11 of our favorite moments in those conversations. More
2013 was a banner year for the Serious Eats ice cream bureau. We played with booze, coffee, and cardamom. We explored ice cream techniques and fundamentals. And we busted some longstanding ice cream myths along the way. For all my favorite recipes, techniques, and science of the past year, read on. More
Do you prefer impeccably grilled Japanese food, extra-crunchy fried chicken, or freshly grilled carne asada? If you're like me, you want all of it, which made it such a thrill to dine out in Chicago this year. More
From bright and tangy lemon Italian ice to super chocolatey haupia pudding, I managed to pack a lot of delicious regional and retro treats into this year. These are my top five. More
From smokey-salty chocolate bark to sublime white hot chocolate, here are my five favorites of the past year. More
We covered a ton of ground again this year in Bronx Eats, eating everything from lemon chicken soup in Riverdale to birria in Hunts Point. We started digging for the north Bronx's best Jamaican food, and picked up an ongoing quest to find the perfect mangu. If this second year of Bronx Eats proved anything for me, its that there's so much more good stuff left to eat and share with you. More
I broadened my fried-food-only focus a little over midway through the year and hit the two year mark as a contributor in November. But whether I was slogging through french fries, fried chicken, top notch doughnuts, or beyond, I was continually struck by just how good it is to eat in Chicago. More
It it just me, or has it been a good year for Asian food in New York, both traditional and modern? If my list of the eight best things I've eaten all year is any measure, then yes. It contains a whopping five dishes built on Japanese, Chinese, Korean, or Thai foundations. The rest are a mix of pasta, rice, and, er, bone marrow. No list is complete without bone marrow, right? More
2013 has been a great year for sandwiches in New York. We welcomed some new favorites with roast beef, brisket, and several kinds of pork. We uncovered some outstanding tortas in the far reaches of Brooklyn and Queens. We explored the subtleties of what makes a great chicken parm. And we said goodbye to one of the city's finest purveyors of mozzarella. Here are our favorite NYC sandwiches from 2013. More