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Welcome to I Love My Authors!!
Today we have the UBER Sinead MacDughlas with us! I have come to know Sinead quite well over the last year and have come to respect and love her dearly!! Stick around because there is a Giveaway at the Bottom!!
Sinead MacDughlas is a Canadian writer whose main addictions are words, music and coffee. A recovered high school drop-out, Sinead has spent much of her adult life moving around the province of Ontario and working at various jobs, including: taxi driver, advertising graphic designer, library clerk, short order cook, industrial cleaner and retail product consultant for a chain of beauty salons. In November of 2011, she finally achieved a lifelong dream of being a published author. Her debut is a self-published collection of short stories and poetry, The Unscheduled Stops.
Mrs. MacDughlas' first full length novel, Learn To Love Me, was signed by one of the fastest rising new Independent Publishers, Crushing Hearts and Black Butterfly Publishing, and released on August 10, 2012.Sinead's most recent work, Best Served Bloody, was just published by Vamptasy Publishing on October 21, 2012. This Halloween themed novelette serves as more than mere entertainment. All proceeds from the sale of Best Served Bloody will be donated to the East Lancashire Hospice in the United Kingdom.
Guest Post
Why an Author?
As long as I can remember, I've had something to say. Actually, if you ask my Mom, I had a lot of somethings to say. According to her, I began talking at eleven months of age and didn't stop, even to breath, from then on.
I suppose that's part of why I became an author. I'm driven to express myself. I'm compelled to share my viewpoint. There are more than a few professions that would allow me to talk endlessly in order to do that. Lawyers, politicians, radio hosts, spokespeople, TV hosts and lecturers mostly rely on their verbal skills for their careers, but I was destined for none of these things.
See, most of those people are relaying facts (well, except perhaps the politicians — and possibly some of the lawyers, but you get my point). The first indication that such careers were not for me was probably Mary Ellen … or Mary Anne … something like that. Mary Ellen was my imaginary friend and she went everywhere with me. She was shy and pretty, dainty and graceful, all the things I was not. Though I no longer remember her exact name, I can still picture her face in my mind's eye. I even remember the day she died. It was traumatic. My very large uncle sat on her, and crushed her to death. I was inconsolable.
Yes, I had a twisted sense of reality, and humour, as a child. ;P The point is, the creation of fiction was etched in my psyche long before I'd given any thought to future career options.
Although I was a well-known chatterbox, I always had a battle with stage-fright, too. Put me in a small group and ask me to tell a story and I'll do so with enthusiasm. Put me on a stage in front of thirty or more people and ask me to tell a story and I'll still do it. In the latter instance, however, it will be a battle to keep my knees from knocking together, my tongue from wrapping around my teeth and my eyes from rolling back in my head.
I've worked for years to overcome my stage-fright, joining school choirs, going to Karaoke and participating in annual public speaking contests. Crazy right? The thing is, I know where the stage-fright comes from and the source has long since been eliminated. On top of always being the smallest, nerdiest, neediest kid in school; on top of always being the new kid in school, I also had a dental glitch. My two front teeth had a huge gap between them, giving me a permanent lisp. Even worse, the more I tried not to lisp the more pronounced it became, causing me to stammer and stutter as well. Thank goodness my Grade Two teacher recommended me to a speech therapist who helped me overcome the issue, although being one of the 'special class' kids did nothing for my social ranking as an outcast at the time.
You can add to these factors my overwhelming urge to help people. I was always hyper-sensitive to other's pain and fear. In the course of my life I've been drawn most to those people that society deems damaged. My strong senses of sympathy and empathy have forever driven me to try to 'fix' people. Age and (I hope), wisdom have taught me that I have neither the means, nor the professional skills to counsel others, but I still feel the need to let people know that they are not, ever, alone. Someone out there loves them. Someone out there understands their pain, fear and sorrow. Someone out there cares.
When I was eight years old, I had to write a daily journal for school. Being a bookish child, with few friends my age and no after-school activities, my daily entries were rather dry. With permission, I began to write a series of short stories about a 'super-dog', roughly based on my Grandparent's Pomeranian. "Peaches the Superdog" helped children with problems remarkably similar to those of my classmates. The teacher was impressed and encouraged me to keep writing. It was then that I realized what I wanted to do with my life. I would be an author.
It took me thirty-two years of stumbling through life before I finally took the plunge. It was a monumental battle against self-doubt and self-reproach, but I made it. My words are finally reaching out to people!
Since then I've found a home with one of the fastest-rising independent publishers to hit the industry: Crushing Hearts and Black Butterfly Publishing. There I've found a family of fellow authors who share my passion for both writing, and for doing good things for others. While their charitable efforts aren't always shouted from mountaintops, each of the CH&BB authors gives all that he or she can to bring more than just entertainment to the world. It's a home away from home like no other, and I'm so grateful to have it.
Useful links for Sinead MacDughlas
Facebook Fanpage: https://www.facebook.com/SinMacD.Writer?ref=hl
Twitter: https://twitter.com/SinMacD
Google +: https://plus.google.com/u/0/107511848516702489145/posts
Goodreads: http://www.goodreads.com/author/show/5339441.Sinead_MacDughlas
Shelfari: http://www.shelfari.com/sinmacd
Amazon Author Page: http://www.amazon.com/Sinead-MacDughlas/e/B0074CIPV8/
Smashwords: https://www.smashwords.com/profile/view/SinMacD
Author Webpage: http://www.author.sinmacd.ca
Blog: http://www.author.sinmacd.ca/blogging.html
The Unscheduled Stops - self published
Purchase Links:
Amazon US: http://www.amazon.com/The-Unscheduled-Stops-ebook/dp/B00727M6S8/ Amazon UK: http://www.amazon.co.uk/The-Unscheduled-Stops-ebook/dp/B00727M6S8/
Smashwords: https://www.smashwords.com/books/view/101241
Barnes and Noble: http://www.barnesandnoble.com/w/the-unscheduled-stops-sinead-macdughlas/1107956624
Webpage: http://www.theunscheduledstops.sinmacd.ca
Learn To Love Me: Crushing Hearts and Black Butterfly Publishing
Purchase Links:
Webpage: http://www.learntoloveme.sinmacd.ca
Best Served Bloody: Vamptasy Publishing
Purchase Links:
Amazon US: http://www.amazon.com/Best-Served-Bloody-ebook/dp/B009UTYWOC/
Amazon UK: http://www.amazon.co.uk/Best-Served-Bloody-ebook/dp/B009UTYWOC/
Webpage: Still to come. ;)
Now for thre Giveaway!!


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Both Lovie Smith and Mike Imrem are "dead wrong." The only way Lovie's call on fourth and one-foot in last week's game was in error was in hindsight.
Based on Bush's recent record, a first down had to be a 90 percent probability.
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Lovie and the other coaches have certainly made enough mistakes this year, but that was not one of them.
John Knudson

subset: commoncrawl


text: Rich JuzwiakProfileFollowUnfollow Rich JuzwiakFiled to: flops Box Office Movies Total Recall Colin Farrell 8/06/12 12:00pm Edit Delete Invite manually Promote Dismiss Undismiss Block for gawker Hide Share to Kinja Go to permalink If Demi Moore is the Queen of Flops, Colin Farrell is their king. Sucks because he's fantastic to watch. 12 Reply 12 Discuss


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National Institute on Drug Abuse Drug Screening Tool API
In an effort to connect developers with the tools needed to host and share the Government's drug abuse research and prevention information, the National Institute on Drug Abuse hosts an API through which they expose their Drug Use Screening Tool. The Drug Use Screening Tool is an interactive multiple-choice quize built to help clinicians identify risky substance use in their adult patients. The API supports GET calls to retrieve questions and results and POST calls to submit answers. The API will return JSONP formatted responses in plain text through HTTP.
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acrylic prints, science fiction acrylic prints, fantasy acrylic prints, steampunk acrylic prints, london acrylic prints, vintage acrylic prints, film noir acrylic prints, automaton acrylic prints, clockwork acrylic prints, robot acrylic prints, city acrylic prints
Mounting Option #1
Mounting Option #2
Bring your artwork to life with the stylish lines and added depth of an acrylic print. Your image gets printed directly onto the back of a 1/4" thick sheet of clear acrylic.
The image is the art - it doesn't get any cleaner than that!
All acrylic prints ship within 3 - 4 business days and arrive "ready to hang" with four aluminum mounting posts (Option #1) or hanging wire (Option #2).
The high gloss of the acrylic sheet complements the rich colors of any image to produce stunning results.
There are two different ways to mount your acrylic print.
Option #1 (Mounting Posts) - Attach your print to your wall with four aluminum mounting posts. The cylindrical cap of each mounting post can be removed, allowing you to thread a small screw along the center axis of the of post and into the wall. When you're finished, simply reattached each cap, and you're done. The mounting posts act as stand-offs and keep your print separated from the wall by 1". All of the required mounting hardware (i.e. posts, screws, and wall anchors) is included with your print. Click here for mounting details.
Option #2 (Hanging Wire) - With this option, your acrylic print is attached to a 1/4" thick black board which has a wooden frame and hanging wire attached to the back. There are no metal mounting posts at the corners. Simply put a nail in your wall, hang your print from the hanging wire, and you're done. Due to the thickness of the black board and mounting frame, your print is separated from the wall by 1.50" Click here for mounting details.
Clockwork "Peelers" patrol the streets of the dystopian Neo-Victorian cage cities. Originally from the Abney Park "Airship Pirates" roleplaying game.The images in our Fine Art America store are specifically formatted and priced for limited-run canvas printing (total lifetime number of canvas prints is 300 each). For prints on archival quality paper, visit our Etsy store (www.etsy.com/people/MANDEMik).
MYTHPUNK ART NOIR MANDEM is a symbiotic pair of artists, Moco and Maize, working together in what might be awkwardly described as a "Vulcan Mind Meld." Our work generally deals with transmutation and evolution -- capturing the metamorphic moments of life where everything changes, and telling the stories of multivalent, multi-textured, variegated things. Current projects include art for Abney Park's AIRSHIP PIRATES roleplaying game books and album art for several bands (including THE CRUXSHADOWS). The images in our Fine Art America store are specifically formatted and priced for limited-run canvas printing (total lifetime number of canvas prints is 300 each). For prints on archival quality paper, visit our ETSY STORE. Visit...
Our return policy is very simple:
If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee.
If you've hesitated to purchase artwork online in the past, why not give us a try? You have nothing to lose!
We take great pride in the fact that 325,065 artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
Customer Service: 877-807-5901
(Call Any Time - 24 Hours Per Day)
All acrylic prints ship from our production facility within three business days of your order.


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Citadel coach Kevin Higgins said Monday he's got a lot of respect for his counterpart at Clemson, Dabo Swinney. He particularly likes the way Swinney has worked out the final weeks of the Tigers' 2013 football schedule.
Who: The Citadel (5-6) at No. 7 Clemson (9-1)
When: Noon Saturday
Where: Memorial Stadium, Clemson
Radio: 1450-AM, 1340-AM, 950-AM
Tv/Internet: ESPN3
"They saw us on the schedule, so they made sure they got another option team, Georgia Tech, the week before," said Higgins, whose Bulldogs play at No. 7 Clemson on Saturday. "And then they moved the Georgia Tech game up to Thursday, so they'd have more time to prepare for The Citadel.
"It's amazing what Dabo will do to gain an advantage."
Higgins, of course, had tongue planted firmly in cheek as he contemplated The Citadel's monumental task in Saturday's noon game at Death Valley. The Bulldogs (5-6) will be heavy underdogs against the 9-1 Tigers, who are preparing for their Nov. 30 showdown against rival South Carolina.
The Bulldogs have lost their last five games against FBS teams by an average score of 51-13, and fell 45-17 in their last visit to Clemson in 2008. This will be the Tigers' second game against an FCS squad this season; they defeated South Carolina State, 52-13, on Sept. 7.
Higgins, in his ninth season at The Citadel, compares this Clemson team to the 2008 Florida squad that beat his Bulldogs, 70-19, on the way to a national championship.
That Gators team was coached by Urban Meyer and featured quarterback Tim Tebow and stars such as Percy Harvin, Carlos Dunlap, Brandon Spikes, Aaron Hernandez, Chris Rainey and Jeff Demps.
"That was, at that time, the best team," Higgins said. "They won a national championship in 2006 and came back and won another in 2008. Certainly, this Clemson team compares with them.
"The thing about Clemson is they are so fast-paced, and that means more plays that we'll have to defend with more speed. And they are concerned with where they are in the rankings, as well, so every point matters to them."
With no FCS playoff berth in the offing for his team, Higgins said the Bulldogs will treat the Clemson game like a bowl game.
"I kind of like having the game at the end of the year," he said. "It's kind of like a bowl game, if you will. But you better be buckled up, because these guys are coming after you. A lot of them will be playing on Sunday afternoon, and you better be at your best when you perform against them."
Many Citadel players watched the Tigers' 55-31 win over Georgia Tech last Thursday. Senior fullback Darien Robinson was not one of them.
"I called my dad, and he said it was getting ugly," Robinson said. "So I didn't even turn it on."
Senior cornerback Sadath Jean-Pierre — who will be tasked with covering Clemson star receivers Sammy Watkins and Martavis Bryant — did watch.
"I saw they just like to air it out and let those guys go get it," said Jean-Pierre, who made his first career interception in the Bulldogs' 35-10 win over VMI on Saturday. "It's going to be a real fun challenge. You see those kids on ESPN every day for making plays, and now we get to see how we match up against them.
"We're going to play against them just like we play anybody else. We're going to play fast and we're going to play tough, and treat them like they are any other human beings."
Citadel linebacker Carl Robinson will have X-rays on the knee he injured against VMI. "We're hoping it is not an ACL," Higgins said. Robinson tore the ACL in his other knee last season.
Saturday is Military Appreciation Day at Clemson. Clemson students are collecting supplies to donate to troops overseas and to families in the community in need of assistance. Clemson also will hold its first-ever "Purple Out", inspired by the military's Purple Heart award.
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Open registration for Fitness Center classes is now available to members and the public. Find the class that's right for you.
Browse and register for classes
Our goal is to help you incorporate physical fitness and exercise into your life as a member of our Fitness Center or a participant in our exercise classes.
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Dr. Scerpella specializes in arthroscopic reconstructive surgery of the shoulder and knee, including anterior cruciate ligament reconstruction, meniscus repair and rotator cuff repair.
Learn more about Dr. Scerpella
Our physical therapists and athletic trainers are skilled in evaluating patients with sports-related injuries.
More information and programs
View our Rehabilitation Guidelines
Dr. John Wilson, a UW football team physician, discussed research, treatment and prevention of arthritis on The Joy Cardin Show on Wisconsin Public Radio.
Listen to the interview (mp3)
Donations to UW Health are managed by the University of Wisconsin Foundation, a publicly supported charitable organization under 501(c)(3) of the Internal Revenue Code.


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We've received news of two very useful user made extensions to NI mate. The first comes from Josh Johnson over at VFXdaily and covers a ready made template that makes it easier for you to rig your character correctly to … Continue reading
Monthly Archives: May 2012
First of all some good news regarding the price of an NI mate license. For buyers located outside of the European Union region the license can be sold without VAT (unlike we were previously made to believe). For EU citizens … Continue reading
Edit 9th of May 2012: We were under the false impression that VAT would need to be included in non-EU purchases as well. We were informed that this is not so and have now corrected the price for non-EU citizens. … Continue reading


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- Mission & History
- Policy & Advocacy
- Fact Sheets & Brochures
- Scholar Stories
- Strategic Plan
- Awards & Recognition
Mimi Daly Larson joined Scholarship America in March of 2011, bringing with her more than 15 years of experience in marketing, communications and fundraising. She is a Certified Fund Raising Executive (CFRE) with significant experience in all aspects of building a successful development program.
She came to Scholarship America from her role as Vice President of Marketing at Greater Twin Cities United Way where she held full responsibility for the marketing department of the largest social service organization in Minnesota. Prior to that she was Principal Consultant for Daly & Associates, where she has provided experienced and award-winning strategic marketing and development services to organizations, mostly nonprofits, for 10 years. Her specialties include leading strategic planning, managing organizational change, social media and online strategies, creating donor segmentation and engagement programs, and all brand management, public relations and marketing programs.
Mimi has served on Boards of several non-profit organizations and has done consulting projects for Boards, leadership teams, HR, community affairs, development and marketing departments in both the nonprofit and for profit sectors. She has a Bachelor's Degree in Speech Communications from Macalester College and a Mini-MBA from the University of St. Thomas, and currently serves on the board of a local non-profit. She is an active participant in local and national politics and has consulted on three political campaigns and served as campaign manager for two municipal races. She has also been a regular guest speaker on Marketing Strategy at the Carlson School of Management, and is engaged in several volunteer activities. She and her husband live in Burnsville with their four daughters.
Scholarship America's Dream Award is a renewable scholarship fund targeted toward completion. These annually-increasing awards will be given to students selected from across the nation who are entering their second year of education beyond high school.
Scholarship America's blog, The Scholarship Coach, appears weekly at USNews.com, featuring expert advice on all kinds of scholarship issues. Here on the site, we feature a new highlight from the blog every week, and you can also download a free Scholarship Coach e-book!
Scholarship America is dedicated to helping students get their degrees. Our 2013 Annual Report, Focus on the Finish Line, features statistics, stories, and student accounts of the importance of college completion.
Visit the online report to learn more and hear from our President, Lauren Segal.


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Bicyclist hit by pickup truck downtown
Driver taken into custody for blood alcohol test
A bicyclist was struck head-on by a pickup truck at the intersection of South Alamo and South Presa Street.
The accident happened south of downtown just before 7 pm Sunday evening.
The bicyclist was identified as Matt Shaw, who was taken to SAMMC with life-threatening injuries.
Police said Shaw was not wearing his helmet.
The driver was making a left turn in his Ford F-250 to go southbound on South Presa. Shaw was going northbound on South Alamo.
Police said the collision occurred in the middle of the intersection, and Shaw was thrown from his bike.
The driver and his girlfriend, who was in the truck, got out to help Shaw. They said he was bleeding from his head and nose and was barely conscious.
The driver's girlfriend said the couple had been drinking earlier in the day.
Police administered a field sobriety test to the driver, but he refused to take a breathalyzer test.
He was taken into custody so police could perform a blood test.
Investigators believe both the driver and Shaw had a green light and the accident may have been the result of a failure to yield.
To view a list of stories that Cory has done, click here.
Copyright 2013 by KSAT.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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All the latest on the newest little royal
Friday April 22, 2011
No riotous antics for Kate Middleton's sister Pippa as she celebrated the engagement of one of their pals on Thursday.
The party was for Virgin boss Richard Branson's daughter Holly, who will marry her shipbroker fiancé Fred Andrews on November 20.
And Pippa, pretty in a peach mini dress, looked as fresh-faced on leaving as on arrival.
Also on their best behaviour at the do were Princesses Beatrice and Eugenie.
Holly and her fiancé are invited to all three parts of the wedding celebrations in Westminster Abbey and Buckingham Palace.
She told the Mirror: "To me they're just two good friends and I'll be happy to be there watching my two good friends get married."
Read full story
All the latest on the newest little royal


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Viewers: in countries Watching now:
In this unique workshop, digital artist Uli Staiger walks you through the process of using source images, a downloaded 3D object, and Adobe Photoshop's tools to create a striking composition. After combining source images and creating layer masks, he shows how to add a 3D object, lighting, and details like steam, corrosion, and a stream of water. Finally, learn to stylize the composition by adding a Hue/Saturation adjustment layer with the Soft Light blend mode. Along the way Uli shows how to work with layer groups, textures, 3D cameras, point lights, and more. Select lessons feature picture-in-picture live footage of Uli working with his pen and tablet, enabling you to see and learn from his techniques up close.
(music playing) Hi, my name is Uli Staiger, I'm a photographer, book author and trainer for many years. I'm born in Germany. For a few years I've been focused on a particular topic, the fascinating possibilities of 3D visualization. After having produced many videos and articles about imaging that combines photography and 3D. I would like to show you how to create cool image using Photoshop's 3D tools, and working with a Wacom tablet. You'll start with a basic image, that shows a submarine in a bathtub. The angle of view is quite special, so the easiest option to put a water tap in the image, is to use the 3D tab.
You'll learn how to place and how to light it. You'll also learn how to shape the object and give it a metal look. After the image is rendered a few nice and really cool 2D techniques will help to create a stunning look. I hope the process of creating this image will inspire you. All the techniques shown can easily be used for your own projects, have fun.
There are currently no FAQs about Up and Running with 3D in Photoshop CS5 Extended.
Access exercise files from a button right under the course name.
Search within course videos and transcripts, and jump right to the results.
Remove icons showing you already watched videos if you want to start over.
Make the video wide, narrow, full-screen, or pop the player out of the page into its own window.
Click on text in the transcript to jump to that spot in the video. As the video plays, the relevant spot in the transcript will be highlighted.


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Old tokens and medallions with local connections
Posted: January 26, 2013|
THIS selection of old medallions and tokens arrived in the post at Bugle House, sent by an anonymous reader, with just a simple note attached: "Sorting through my late husband's things I came across these sort of commemorative items and wondered if they may be of interest to you." Indeed they are of interest and we thank our nameless donor.
The three pieces are of an early 19th century token, a gardening medal, and a commemorative medallion for the opening of Wolverhampton Art Gallery.
In the late 18th and early 19th centuries, as Britain was embroiled in the Napoleonic wars, the domestic economy was struck by a shortage of currency, particularly pennies and halfpennies. This affected employers who struggled to find the cash to pay their workers. To get around the shortage many businesses minted their own tokens with which they paid their staff, who could then use the tokens to pay for goods at local shops.
This example from the Rose Copper Company is typical of the kind. In 1811 they issued penny and halfpenny tokens, one side bears the company name and date and the other side gives the value and where the company was based – Birmingham and Swansea.
The company was founded in around 1792 by a group of Birmingham businessmen, among them the most prominent Birmingham manufacturer of his day, Matthew Boulton.
The Rose Copper Company supplied him with the copper he needed for his many minting contracts and this token was made by Boulton at his Soho Mint.
The company initially operated in Cornwall before taking over smelters in south Wales in 1797. It appears to have ceased operations in the early 1820s as in 1823 John Williams and his sons, in partnership with others, took over the Rose Copper Works in the Swansea valley.
Our second item is an post- First World War example of the Banksian Medal, awarded by the Royal Horticultural Society and named after one of its founding members.
The society began as the Horticultural Society of London and was the idea of John Wedgwood, son of the famous potter Josiah Wedgwood. The first meeting was held on 7th March, 1804, Wedgwood was chairman and he was joined by Sir Joseph Banks, President of the Royal Society, William Townsend Aiton, Superintendent of Kew Gardens, James Dickson, a noted botanist, William Forsyth, Superintendent of Gardens at St James's Palace and Kensington Palace, Charles Francis Greville, politician and antiquarian, and Richard Anthony Salisbury, who became the society's first secretary. The society was granted its royal charter in 1861.
Sir Joseph Banks (1743-1820) was a celebrated botanist, naturalist and scientist. He introduced many exotic plant species, such as eucalyptus, mimosa and acacia, to the western world and has around 80 species named after him, the best known being the Australian flowering plant Banksia.
In 1766 Banks sailed to Newfoundland and Labrador to study their natural history and he followed this by joining Captain Cook's first expedition to the southern Pacific, 1768-1771.
In 1778 he was elected President of the Royal Society and held the position for 41 years. In this role, and as advisor to George III on the Royal Botanic Gardens at Kew, Banks promoted many voyages of discovery, such as George Vancouver's exploration of the northeastern Pacific and William Bligh's ill-fated breadfruit expedition aboard HMS Bounty; Banks also fostered the colonisation of New South Wales.
The Banksian Medal is awarded by horticultural societies affiliated with the RHS.
Numbers are strictly limited and generally the individual societies are only allowed to award one Banksian medal a year.
This particular medal was awarded on 18th July, 1919, to H. Davies of Birmingham for vegetables. Unfortunately, it appears that this medal was not well struck as some of the letters in the inscription are unclear, possibly due to wear and tear on the original die. The inscription should read, "Sir Joseph Banks BT PRS Born 1743 Died 1820".
Our last item is a large medallion in white metal struck to commemorate the opening of Wolverhampton Art Gallery on 30th May, 1884. One side bears in impressive relief depiction of the art gallery building, which was designed by the Birmingham architect Julius Chatwin and built by Horsman and Co.
The building is noted for the relief sculptures on the upper storey, the work of the firm Richard Lockwood Boulton and Sons, with 16 figures facing onto Lichfield Street, representing art and sculpture, and 18 figures facing St Peter's Close, depicting the sciences.
The opening ceremony was conducted by Arthur, 3rd Baron Wrottesley, Lord Lieutenant of Staffordshire, using a golden key made by the local firm of Chubb and Sons. The building cost £8,500, defrayed by Philip Horsman, who also bequeathed his collection of paintings to the gallery.
The obverse reads "Wolverhampton and Staffordshire Fine Arts and Industry Exhibition" with the town's original coat of arms. When the town council was established in 1848 these arms were adopted although they were not granted officially by the College of Heralds.
When the council celebrated its jubilee in 1898 it applied for official arms and the design was simplified into the single shield we know today and the Latin motto, E Tenebris Oritur Lux, was translated into English, Out of Darkness Cometh Light.


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Gail Slagle Hamaker, age 44, passed away at her residence, on Saturday, March 3, 2012, in Powell, Tennessee.
She was born August 28, 1967, in Columbus, OH, to the late Charlie and Sue Slagle. Gail had lived in Johnson City for 15 years prior to moving to Powell, Tennessee, five years ago.
Ms. Hamaker is preceded in death by her parents and her husband, Gene Hamaker.
Gail is survived by two sisters and brothers-in-law, Marsha and Anthony Sheppard, of Johnson City, Rennie and Forrest Penwell, of London, OH; two brothers and a sister-in-law, Carl and Katie Slagle, of Canal Winchester, OH, and Vernon Slagle, of Johnson City; a special nephew, Jesse Greenwell, of Hampton, TN; her fiancé, Scott Cozad, of the home; and additional nieces and nephews.
Online condolences may be sent to the family of Gail Slagle Hamaker by signing the online guest registry found on the funeral home's website (www.snydersmemorialgardens.com).
Serving the family of Gail Slagle Hamaker is Snyder's Memorial Gardens, funeral home of Gray, TN.


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Charles R. Hale, Director SRH 1.310, 2300 Red River Street D0800, Austin, TX 78712 • 512.471.5551
Symposium and Concert: ''Music and Culture in the Imperial Court of Joao VI in Rio de Janeiro''
Tue, March 8, 2005 • 8:00 PM • Bates Recital Hall
A symposium and concert examining the artistic production of Rio de Janeiro in the late 19th century. The UT Chamber singers will perform Jose Mauricio Nunes Garcia's Missa de Nossa Senhora da Conceicao. Free tickets at door on first-come basis.
For more information, visit www.utexas.edu/cola/depts/llilas/events/missa.html or call LLILAS at 471-5551.


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Oct 01 2010
Mike and I used to give each other manicures and pedicures with watercolor sets.
I took that a little farther once I became a preteen: I'd sneak into his room and put lipstick on his lips while he slept.
Bright shocking red lipstick. Elizabeth Arden. My mom's.
The next morning I'd wait till he woke up, then listen as he stumbled into the bathroom and closed the door.
Then, like clockwork, within seconds, it would come:
Ahhh…sibling love.
I have the best memories with Mike. They involve calling 911, singing "Elvira," and ant and roach killer.
P.S. Mike's having gall bladder surgery Saturday morning (was just changed from today).
He's not feeling great. Believe me, he's told me so.
"Mike, how you feeling?"
"N-n-not good."
If you said a little prayer for him, I'll bet you anything he'd feel it.
713 Comments and 22 Replies
Tara On Monday, October 4 at 4:04 pm
Meanie Pee-Pee Hot Dog were the cuss words of choice when my 6 year old got mad. She has cerebral palsy and boy they would spew from her lips if she was mad. Thank goodness, now that she's almost 21, it didn't get any worse than that!
She had her gall bladder removed last summer. No more tummy pain. She said a prayer for him last night.
Sandy H. :) On Monday, October 4 at 5:09 pm
Been thinking bout'cha all weekend, Mike! Hope you're feeling LOTS better!
Michelle On Monday, October 4 at 5:41 pm
Said a prayer for Mike!
wendi adams On Tuesday, October 5 at 9:57 am
prayers on the way. Your brother is the Bomb!
D. Marie On Tuesday, October 5 at 10:33 am
I love Mike! Tell him I feel his pain. I'll have to have mine out pretty soon. Sending prayers and hugs.
mamawehner On Tuesday, October 5 at 11:09 am
Praying for Mike, the doctors and nurses doing the procedure, and your whole family!
Cate On Tuesday, October 5 at 12:54 pm
Hope Mikey is doing well… please post an update?
Dot On Tuesday, October 5 at 2:03 pm
Best wishes to Mike for a speedy recovery!!!!
Leah On Tuesday, October 5 at 5:46 pm
Praying for Mike.
Momma Louie On Wednesday, October 6 at 12:54 pm
How about a Mike Update? Still praying for him…just wondering how he is doing!
Pearlene Lunsford On Friday, October 8 at 11:48 pm
I had dinner with Mike at Buffalo Wings in Bartlesville Tuesday, Oct. 5th, He was still taking it easy. He also said he was going to Texas to see him Mom on Saturday, Oct. 9th. My neice Kim Lunsford gave him an "OU" hat and he was wearing it proudly. Ree, you will have to ask him about Kimey. MIKE LOVES ALL THE GIRLS IN BARTLESVILLE.
shauni On Tuesday, November 9 at 1:24 pm
holy hell, i do not know how i just found this post, but turkey damn butt hell ass has made me laugh so hard that i spit out my hummus. thank you for sharing this story.
assuming the surgery went well last month?
Tonya On Thursday, January 27 at 1:14 pm
I love stories about Mike. You are a good sister. God bless you all!


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Hold down Control (PC) or Command (Mac) key + mouseclick to select more than one option
|Avg. Dinner Entrée
|Greater than $25
|$18.01 - $25
|$12.01 - $18
|$7.01 - $12
|Less than $7
Posted by Gal on 02/15/2015
Went on a Sunday night so I expected a wait time...decided to continue and waited 45 minutes for a table for 3. Finally got seated only to wait an additional 20 minutes for our waitress to show up. She never did so we showed ourselves to the door and spent our hard earned money somewhere else. This place is an absolute embarrassment and shame on you for ignoring my
Posted by barbara on 02/20/2011
visited this location only to find that the chicken anna maria was no longer on the menu. i settled for the chicken marsala. not very happy with my choice. my meal came out almost cold. the chicken pieces were very thin and not as large as i remember. i used to be able only to eat one piece of chicken but i had no problem eating both pieces. the spinach had a strange taste so i did not eat that. i did enjoy the sausage soup but that was not hot either. do the meals just sit around getting cold until some one decides to bring them to the table. soup should be so hot that you have to wait for it to cool a little. i like the old salad better than the way the new salad is being served. we celebrated a birthday there not too long ago and they served the new salad and i thought they were serving that salad because it was a special occasion. was sad to see that is the salad that is now served. rolls and oil were delicious as usual. they came out hot.
Posted by T on 08/03/2008
the staff at this location are all very friendly, outgoing and a pleasure. The only complaint I have is that they took the portabello appetizer off the menu - grrrr. This appetizer was fabulous and it was hearty enough to be a meal. Please bring it back. I was at the location yesterday and was saddened to hear that it is no longer on the memu


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Community invited to "Shadows of Love" Christmas program
HURRICANE — Community members are invited to a unique retelling of the Christmas story when Mount Vernon Baptist Church presents "Shadows of Love" at three different churches during the coming weeks.
Described as a "silhouette drama," the script was written by the Rev. Ron McClung, who is the senior pastor at Mount Vernon Baptist. The Mount Vernon Baptist Choir is under the direction of Rodney LeGrand.
"This is a dramatic, multi-sensory presentation of the Christmas story, from creation to the flight to Egypt," McClung said in a news release. "Attendees will hear, sense, and see the story in a unique way. We have worked on a silhouette drama that shows the incarnation of God into this world, using a variety of music, color and narration."
McClung said he wrote "Shadows of Love" 10 years ago, and it was originally intended as an Easter drama, and he later modified it to reflect the Christmas season. It has been performed at churches in Kentucky and Ohio, where McClung previously held pastorates.
Performances of "Shadows of Love" are planned for:
- 7 p.m. Wednesday, Dec. 19, at Judson Baptist Church on Bill's Creek Road
- 7 p.m. Saturday, Dec. 22, and 11 a.m. Sunday, Dec. 23, at Mount Vernon Baptist Church
- 6:30 p.m. Sunday, Dec. 23, at Main Street Baptist Church, Point Pleasant.
"This is a great opportunity to invite family and friends to share the joy of His love through the journey of 'Shadows of Love,'" McClung said.


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Posted at: 05/07/2013 11:24 AM
The Lilac Festival is just a few days away and on Wednesday, a group of volunteers will spruce up a part of Highland Park where thousands will visit during the course of the festival.
Volunteers from Camp Good Days and Special Times will start raking, mulching and cleaning "Teddi's Place" at 9 a.m. Wednesday.
Teddi's Place is named after Teddi Mervis who was the inspiration for many programs that have come out of Camp Good Days and Special Times for kids with terminal illnesses.


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Pristine, 1-owner 2013 Tesla Model S with only 11,799 miles. Optional 85kWh battery, 416hp/443lb-ft torque. Grey Metallic with Black upholstery, Tech Package, Studio Sound... More
2013 Tesla Model S Performance+ FOR SALE!!! Comes finished in a Gloss White exterior over a black leather interior. Standard Equipment includes: Three phase, four pole AC... More
2010 Tesla Roadster Sport for saleExotic Classics is proud to present a rare 2010 Tesla Roadster Sport finished in Fusion Red over a black... More


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Apr 01, 2008
I'm listening to these girls chat at the coffee house. They must be young, just out of college or fifth year seniors. They splatter the word "like" over their conversation the way we used aquanet in the 80's over our bangs. It's obvious one girl is more in to the other. The one with the boobs, she's the one carrying the conversation. She also slaughters low cut like a hungry butcher. The boobs, they pour out in overflowing pale whiteness.
I'm practically blinded.
The other girls is sensibly dressed, obviously the more mature of the pair, conservative but hip. She's sitting back, leaning on her left arm while her friend leans forward almost throwing her words at her.
Being young is terribly awkward, isn't it?
It makes me think of friendships you tried so hard to hold on to. People who wanted to hang out with, to share stories with. People you maybe had something in common but then became on the fringe of their life. It happens to everyone, it's happened to you. It happens in blogworld and in realworld and in life in general. Your Way Totally BFF Like OMG Totally might move to, say, Ohio and marry someone she met on the Internet and you'll be left wondering what ever happened to so-and-so and remember-when? Or the person who's wedding you were in four years ago that you lost touch with but glance every so often in the peripheral of life. These girls are new in life, barely 21, with boyfriends and no children. It's a Tuesday at 3pm and they're in a coffee shop talking about college courses. They're on Spring break. They have a Spring Break.
Remember Spring Breaks?
They may stay friends for a few years more. They may be in each others wedding, wearing fancy low-cut dresses and dancing in nylons. They may send a Christmas card once a year and marvel at the children who grow like weeds.
And then they'll be left telling their husbands about this friend they used to have back in 2008… remember her? What was her name?
Remember anyone like that in your life? I do.
yes, yes, YES!
Great post, Leslie.
Oh and by the way, we DO need to get together for drinks, even though I'm a total flake…!
By bananas on 2008 04 01
Like, OMG! Like, totally! Like I can sooooo totally relate to that! Like OMG!
By themommykelly on 2008 04 01
Ohio and marry someone she met on the Internet
ok my ears are burning. or perhaps that is a total coincidence
By Kate Ruff on 2008 04 01
Funny, I was just thinking about trying to dig up a few old acquaintances tonight.
By laura on 2008 04 01
Yep. Absolutely. And I thinking about looking them up and am afraid they wouldn't remember me.
By Ree on 2008 04 01
I have several people in my life like that. People I just *knew* I would be friends with forever. Now I don't even know how to get in touch with them.
But, it's probably just as well anyway, because really, what would I even say?
By Beth_C on 2008 04 01
Oh, yes, I remember those friendships. I mourn those friendships sometimes. It's so much harder to connect with people now in the same way we did when we were 20.
By LifeAsIKnowIt on 2008 04 01
LIKE OMG I TOTALLY remember being like that. Still are when I'm LIKE TOTALLY DRUNK N" STUFF. Remember Sara Jo? She got married and moved to colorado…lost her email…crap. I have NO way of getting to her. LIKE BUMMER!!!
By sister flinger on 2008 04 01
Dude, could you like have hit the nail any more dead on in the center?
I occasionally e-mail 2 of my 8 bridesmaids.
I remember those friendships and I smile at them. I get tugs on my heartstrings, but then I look at the friends I have now and my heart does flip flops, they are so much more real and substantial.
Great post sweets.
By rachel on 2008 04 01
I think we all do. Great post.
By RB on 2008 04 01
Yes, we must all have friends like that. I was, truly, thinking of a couple "really good friends" I had in college just yesterday. For the life of me I can't remember their names. Who would have thought I would have forgotten them? Dang, makes me wonder who has forgotten my name! But I do hope they recall my face with good memories.
Thankfully, I remember yours (ROFL).
By hilary on 2008 04 02
Like, for real!
Cool beans post!
By Queen of Shake Shake on 2008 04 02
I marvel at this phenomenon. It does happen to everyone. For me though, it turned out that I lost contact with my closest friends from high school for awhile, but now we have all re-connected, and realized that we have the only TRUE friendships any of us have experienced in our 43 years. They've always been there for me, and I could always pick up the phone, even during the times we weren't really "in contact."
I think where you live has a lot to do with it too, or where you work. Some of the people I've been so close to sort of "fell away" when I moved or quit my job, etc. I guess we're just fickle creatures!!!
By Katie Kat on 2008 04 02
I so can identify with this…
What is Spring Break again? Oh, hell what is a BREAK for that matter?
Its funny that my closest friend is the one that I have had since I was 13. And while we see each other like once a year…its like we never left each other.
That is the kind of friend that I want to keep in my life.
Not what's her name with the pasty white boobs and the loud mouth who stole my boyfriend in college.
By Faith on 2008 04 02
Um. Yep.
By MammaLoves on 2008 04 02
Great post! And can so totally, like, relate.
By Suburban Mum on 2008 04 02
i fucking want spring break. WHY DON'T OUR JOBS GIVE US SPRING BREAK!?!??! ugh.
i think growing up, you kind of know who is going to be in your life forever- or at least you think you know. i haven't been surprised really by who is gone and who is still here when it comes to my friendships…
By jennster on 2008 04 02
Great post as usual… I am giving you an award if you want to pop by my blog and pick it up!
Jen R
By Jen Rizzo on 2008 04 02
I can honestly and sadly say that I never had friendships like that. I'm not very good at making friends in the beginning, and when I do, they tend to be the ones that stick. My best friends are spread all over the country, now, but we keep in touch by phone, e-mail, Facebook (how I love thee).
By Mrs. Mustard on 2008 04 03
I have so many friends like that! It's such a sad thing… esp the ones that I tried to make an effort with and they just didn't reciprocate.
By Holly on 2008 04 03


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Previous CAHR fellows have come from disciplines as wide-ranging as the history of science, philosophy and English literature.
Please check back in the coming months for further information on each of our fellows and their thoughts on the collections.
Read our FAQs on working with CAHR and find out more about what we do.


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DANVILLE - Betsy Layne journey in the postseason ended on Friday night as the Bobcats fell to host Danville in the opening round of the Class 2A State Playoffs. Danville moved out in front early and pulled away to beat visiting Betsy Layne 67-12.
With the win, Danville moved to 8-3, advancing to the second round of the Class 2A State Playoffs. Betsy Layne concluded its latest season 7-4.
Danville set the tone early Friday night, outscoring the Bobcats 39-6 in the opening quarter. The Admirals added to their lead in the second period, blanking Betsy Layne 28-0 to lead 67-6 at halftime.
Betsy Layne scored its second and final touchdown in the fourth quarter.
Jawan Grey and Devonta Alcorn led Danville with three touchdowns apiece.
The runner-up out of Class 2A, District 7, productive Danville needed only 374 yards to score 67 points. The Admirals, under the guidance of legendary head coach Sam Harp, also scored on a kickoff return and an interception return.
The Bobcats exited the season 7-4. With the season-ending loss, Betsy Layne had three-game winning streak snapped.
Betsy Layne picked up the majority of its yardage against Danville through the air. Junior quarterback Dylan Hamilton led the Bobcats. Hamilton completed 11-of-25 passes for 170 yards and one touchdown.
Blake Spencer hauled in a scoring catch for the Bobcats.
Dustin Rogers led Betsy Layne receivers with three catches for 52 yards.
Danville held the Bobcats to 25 rushing yards. Houston Hall led Betsy Layne on the ground, rushing five times for 20 yards and one touchdown. Hall also has three receptions for 33 yards.
Danville will visit Class 2A, District 8 Champion Prestonsburg this week. The Blackcats defeated Middlesboro 36-33 Friday night.


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Today Gunaxin posted some fabulous Embarrassing Old-School Celebrity Video Game Ads. Among them, Pete Rose and Don Knotts (you read that correctly) are pimping Atari in 1978. The ad is awesome beyond words. Really, see for yourself.
And while Pete was swinging at virtual pitches back then - he's still making moves with the ladies 30 years later. Via Sports By Brooks, we learn that Pete's lady friend is going to pose for Playboy. Whether its video games or women, he certainly earned the nickname Charlie Hustle.


text:
Internet Technology Group Pty Ltd
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DIMENSIONS: 177 x 117 x 31 mm (w x d x h)
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text:
Native Instruments today shared this teaser video for a new 2+2 DJ control mixer, rumored to be named the Kontrol Z2.
Specs and details are to come, but you can infer a lot from the teaser video.
Check it out and let us know what you think!
Native Instruments today shared this teaser video for a new 2+2 DJ control mixer, rumored to be named the Kontrol Z2.
Specs and details are to come, but you can infer a lot from the teaser video.
Check it out and let us know what you think!
2011 NAMM Show: Numark introduced the iM1 DJ mixer, a professional 2-channel DJ mixer and the iM9, a professional-grade DJ mixer with integrated effects, both featuring built-in docks for iPod. Continue reading
Pioneer and Serato Audio Research introduced the DDJ-S1, a new DJ controller for Serato ITCH software, at the 2011 NAMM Show.
The Pioneer DDJ-S1 for Serato ITCH is an all-in-one Digital DJ controller, combining Pioneer's hardware design with DJ software by Serato. Continue reading
2011 NAMM Show: FutureMusic points out that the new Behringer DJ mixers look strangely familiar…..
Behringer DJX900USB & Pioneer DJM700 – separated at birth?
Free Windows Music Software: V-DJM 2ch is a virtual 2ch mixer with dj functions for Windows. According to the develoeprs, the free virtual DJ mixer is designed to reproduce the best features of the professional dj mixers in any audio host application.
V-DJM can be used as an internal mixer in your host audio applications with the sound and the feeling of a dj consolle. All controls of V-DJM can be midi-mapped and automated.
V-DJM 2ch is available now as a free download.
Note: MAFFIALIFE V-DJM 2Ch is free for non-commercial use. Continue reading
Pioneer has announced a new DJ mixer, the DJM-2000, that's the iPad of DJ mixers.
The DJM-2000 is Pioneer's most powerful performance mixer and is designed to be the perfect match for CDJ-2000 digital decks. It features a 5.8-inch LCD multi-touch panel display, a first on a DJ mixer.
Other features include Beat Effects, Instrument FX, serious connectivity, a live sampler, USB audio interface, 3-band EQ, digital audio in and three different mixing modes.
All that sexy comes at a price, though. The DJM-2000 is expected to be available in June 2010 with a suggested retail price of $2,999. Continue reading
NAMM: Rane and Serato introduced the Rane Sixty Eight, described as "the ultimate club mixer". The Rane Sixty Eight is the first Scratch Live compatible DJ mixer that allows two computers to be connected simultaneously.
Above, Anna from Serato offers an overview of the Rane Sixty Eight. Continue reading
DJ Tech Tools takes a look at the new Allen & Heath Xone DX, at the 2010 NAMM Show.
via eangolden


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MUSIC NOTES: Pink's 'Try' Music Video & More
Music notes; because let's face it, #musicrules.
Enjoy these fun stories hitting the web today in our gallery edition of Music Notes! Keep clicking through and let me know your thoughts on each story!
Pink's new music video for her single "Try", Every Avenue's December touring plans, and Jack White's new music video for "I'm Shanking".
Let's talk music, let me know your thoughts in the comments below!


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|Send an Inquiry:
Hi Van,
Recommend cycling early in the morning- the heat is very bad in the middle of the day. Frozen water in bottles might be good to help with the heat.
Hotels should serve espresso coffee
I love the backroads. Wow, much better than I expected
- Excellent guide, so friendly, so helpful
- Smiling, cheerful, happy driver
- Great bikes
- Viet Cong boat trip, crocodile farm
- Scenery is superb
.......Sarah Thornton from Australia
Best tour ever. Dat is excellent and we were looked after perfectly
We also love the drive hugely. He was very good
Dat is the best guide I have seen
I love the tour
Thank you so much
Dean Thornton from New Zealand
Great bicycle tour and our guide was excellent
Ashley and Lynn Lindon from Australia
Hi Vietnam Backroads,
We are home now unfortunately, having just spent our first week back at work.
Matt and I thoroughly enjoyed our Vietnam Backroads trip, despite my feedback. Our tour guide Dat and Mr Van were fantastic in immediately recognising my limitations and adjusted the cycling routes and distances accordingly to more closely suit my abilities.
The tour itself was good value for money and extremely well organised with high quality, centrally located hotels and a never ending supply of delicious local food!
We loved our time in Vietnam and agree that cycling Vietnams backroads is definitely the best way to see the country.
We would certainly consider another trip with you (at a shorter distance!) and recommend Vietnam Backroads to friends and family. 16th - 29th Mar 2014
Good combination of physical extension, interesting combination of cultural exposure & experiences, great food, excellent guide and bikes.
We will recommend your services to others.
Feel free to send me trip tour updates as you created more tour packages in future.
December 22, 2013
Thanks to Dat- our tour guide, we had more than just a backroad cycle - this was a full cultural tour including local food. I have life threatening peanut allergies and he guided me with what to eat and made sure I was ok. Great scenery, lots of flexibility to stop when we wanted to take pictures. Dat was able to explain so much to us about the way of life for Vietnamese people, rice growing, weddings, funerals, etc, all the things we saw along the way.
Thanks for an amazing memory.
December 22, 2013
Hi Vietnam Backroads,
Thanks, this was amazing. I will rave about it. Now we have done the best bike trip in the world we can retire! Great variety of scenery.
December 22, 2013


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Fastrax enhances the world's smallest GPS antenna module
The new Fastrax UC530 GPS module with integrated chip antenna combines market-leading performance and sensitivity with extremely low power consumption
Fastrax today introduced the Fastrax UC530 - a new edition of the world's smallest OEM GPS receiver with an integrated chip antenna. The module features the same ultra small form factor as the widely popular Fastrax UC430, while providing new benefits to designers, developers and manufacturers of handheld digital devices.
The Fastrax UC530 features the highest sensitivity on the market (-165 dBm in tracking) and extremely low power consumption, typically only 45 mW average power. The antenna module is easily embeddable in space-restricted environments thanks to its tiny footprint of 9.6 x 14.0 x 1.95 mm and extended input voltage range of +3.0V...+4.3V. The ability to directly connect the module to a lithium battery allows hardware designers to omit cost-adding regulators. Full SMT design reduces the need for external components and minimizes manufacturing costs.
The integrated chip antenna of the Fastrax UC530 exhibits significantly better radiation efficiency than small patch antennas and performs well against larger and heavier patch antennas. Its circular radiation pattern brings flexibility to hardware design. The optional connectivity to an external GPS antenna extends the applicability of the module to a wider range of devices from handheld computers to asset tracking systems. When the optional external antenna is used, the embedded antenna works as a low-cost back up.
The new power-saving AlwaysLocate mode prolongs battery life while maintaining location information, similarly to the newly introduced Fastrax IT530 GPS receiver module. Depending on the environment and motion, the module adjusts its navigation activity to balance positioning accuracy, fix rate and power consumption. In addition, the Embedded Assist System (EASY) reduces warm-start TTFF by up to 90% with autonomously calculated ephemeris data for next three days. The additional server-assisted EPO™ file transfer extends the external A-GPS service to up to 14 days when desired.
"Location-aware features and applications are increasingly becoming mainstream in all sorts of digital devices, which is equally exciting for users as it is challenging for hardware providers," said Fredrik Borgström, VP of GNSS Receivers at Fastrax. "Hardware designers, developers and manufacturers are faced with the difficult task of providing accurate and reliable positioning in all kinds of small size devices, while time-to-market and price pressure call for minimal extra engineering effort and the lowest possible cost. The new Fastrax UC530 is built with these needs in mind: a complete low-power, high-sensitivity and high performance GPS receiver with an integrated antenna. Packaged in a tiny casing, the module is easy to integrate in a wide variety of devices at low cost."
The embedded jammer remover in the Fastrax UC530 helps solve issues with distorting signals due to electromagnetic interference (EMI). Active Interference Cancellation (AIC) tracks and removes up to 12 CW (Carrier Wave) type EMI sources up to -80 dBm. Also embedded is the LOCUS logger function, which stores location information in the internal memory of the Fastrax UC530. With a typical log interval of 15 seconds, log capacity is 16 hours.
Engineering samples of the Fastrax UC530 are available in the end of June 2012, and mass production is estimated to start in the end of August 2012. Documentation is available now at www.fastraxgps.com.


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Stewart Downing is hoping to continue his fine form in the FA Cup for Liverpool against Chelsea on Saturday after enjoying two special moments in the competition this season.
A Kop end strike against Oldham in the third round was his first goal in a red shirt and then he hit the winner against Stoke City in the quarter-finals at Anfield.
And despite being named Man of the Match in the Carling Cup final victory over Cardiff City, Downing admits his brilliant winning strike against the Potters gave him the most personal satisfaction.
"That was a great feeling, scoring my first goal for Liverpool against Oldham, and it was a long time coming," Downing told Liverpoolfc.tv.
"I had been hitting the post and the bar, which has probably been the story of my season, but you've got to keep getting in the positions and trying to score.
"Scoring against Stoke was even better because it got us in the semi-finals, which was probably my proudest moment at Liverpool.
"It was certainly up there in terms of one of the best goals I've scored. Me and Stevie played a one-two that we had been working on in training, and it was great to score and see us in the semi-finals.
"Hopefully I can emulate that and get a better one on Saturday, and hopefully the winning goal. But if the other lads score and we win the game then that's the main thing for me."
The England international is relishing the prospect of a third return to the national stadium this season and is eager to win more medals in a red shirt.
He added: "It will be our third appearance there this season, so it feels like it's becoming our second home. We've got some good memories playing there and hopefully we can come back with some more.
"We had a great day against Cardiff and we got our first trophy, which is important for a new-look team. Now we want more."
While confident Liverpool can get the right result, Downing knows the qualities the Champions League finalists possess.
He said: "I think it will be our biggest test of the season. No disrespect to the other teams we have played like Cardiff and Everton, but they are a strong team with big characters who have been there and done it.
"They will be up for it as well and there is a lot at stake but we are looking forward to it and are really confident we can win the game.
"I watched the Champions League semi-final. Obviously they did really well and I didn't expect they would hold on, especially against a team like Barcelona, but all credit to them.
"They have done quite well since the turn of the year but that's football and it's about who turns up on the day.
"Before the semi-final everyone said Everton would beat us because they are the team in form, but look what happened. It's about who wants it more.
"We are playing for Liverpool who are used to playing in big occasions so we are looking forward to this."
Kenny Dalglish's charges have already beaten Chelsea twice this season and Downing insists Roberto Di Matteo's team will not be relishing the prospect of facing Luis Suarez, who netted his first hat-trick in a red shirt last weekend at Norwich City.
He said: "The hat-trick wasn't bad, was it? Especially his second and third goals, which were great finishes.
"He's a big player for us and we need him on form. He had a bit of a rest on Tuesday so hopefully he will be ready to go and I'm sure the likes of John Terry won't be looking forward to playing against him because he is a nightmare for defenders.
"He is unpredictable and can come up with things that other players can't.
"I'm confident we can beat them. Some players don't win anything in their career so to be in with a chance of winning two trophies is absolutely brilliant."
If the final was to go to penalties, then after netting a crucial spot-kick against Cardiff, Downing would certainly step up to the plate again.
"I would definitely take one again," he added.
"If there is an opportunity to take a penalty for your team at Wembley when you've got a chance to win a trophy then no problem, I'd go up again, but hopefully we can win the game in normal time."
Tagged: Chelsea , Downing , FA Cup , FA Cup final , Stewart Downing , Wembley
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The Billy Bob Tapes: A Cave Full of GhostsHardback
List price $26.99
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- Format
- Paperback $13.24
- Publisher: William Morrow & Company
- Format: Hardback | 272 pages
- Dimensions: 157mm x 224mm x 33mm | 567g
- Publication date: 15 May 2012
- Publication City/Country: New York, NY
- Illustrations note: black & white illustrations, colour illustrations
- Sales rank: 1,324,309
Product description
Raised in small-town Arkansas, Billy Bob Thornton grew up amid a rich storytelling tradition. See, the South is just different than other places. . . . You can feel the ghosts there. As a kid, he would sit on the porch listening to his family or some old man down the road spinning yarns about colorful neighbors. These stories didn't have to be made up. The characters were already there, so the stories just came out of the characters we knew. Thus was borne his Oscar(R)-winning masterpiece Sling Blade and now The Billy Bob Tapes--a narrative based on late-night conversations with Kinky Friedman and other friends who gathered 'round to hear Billy mine a cave full of ghosts.Billy grew up shooting squirrels, playing drums in VFW clubs, and dreaming of rock 'n' roll stardom or pitching for the St. Louis Cardinals. Then at sixteen he took a drama class to meet chicks--and met Mrs. Treadway, who noticed the young man's talent and encouraged him as an actor and writer. "You don't know what it's like to be a drama teacher in a small town in Arkansas where nobody really cares," she said, "but let me tell you something. You can do this." These stories didn't have to be made up. The Everything I've accomplished since, I can trace back to this woman, Maudie Treadway.The colorful characters, stories, and experiences of his youth would find their way into Billy's work, in his films and music, and in his perspective and attitude. It's like the old saying goes: you can take the boy out of the hills, but you can't take the hills out of the boy. That boy did leave the hills--for Hollywood Hills. A true fish out of water, he recalls stories of miserable jobs, the cheapest accommodations, and physical hunger--but also a devoted writing partner Tom Epperson, a life-changing acting teacher in L.A., and a compassionate nurse who snuck him milk shakes when he was near starvation. But there was always the dream of being an actor, and his fortunes turned when he served hors d'oeuvres as a catering waiter to legendary director Billy Wilder, who advised him, "Write about your interesting life."Billy's long career in Hollywood yields stories of inspired collaborations and failed ones, true friendships with other actors and musicians, and good friends gone too soon. In The Billy Bob Tapes, he reflects on the critics, the culture around fame, and the challenges of conveying an artistic vision in film. Most striking is Billy's clear-eyed perspective about the magic of entertainment, and how we perceive it in a rapidly changing world. With passion, unvarnished honesty, wry humor, and a little help from friends Angelina Jolie, Robert Duvall, Dwight Yoakam, Tom Epperson, and Daniel Lanois, Billy Bob finally talks.
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"As a writer, Billy Bob puts Tennessee Williams in the back seat."--Robert Duvall


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Tour de France Stage 21 (Final)
From: 2016.07.21 To: 2016.07.22
Official website:
The final of the Tour de France ends in Paris, and it is difficult to imagine a finer finish to any race. After three exhausting weeks of racing the cyclists hurl themselves down the Champs-Élysées with thousands of Parisians lining the avenue cheering them along. As the champagne flows on the winners podium, bottles begin popping all over the city and the celebration continues well into the night. This insanely-difficult, leg-pumpingly exciting Lycra-clad extraordinaire was born in 1903 amidst much eye-brow raising and jaw-dropping. The French people soon took the Tour de France to their hearts however as it placed their towns, their countryside and their mountains in the spotlight. The Tour de France covers 3,500km over 21 gruelling stages: 10 flat stages, 7 mountain stages, 1 medium mountain stage, 2 individual time-trial stages and 1 team time-trial stage. The current leader is always possible to spot, as he'll be wearing the coveted yellow jersey.
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- Filed Under
Q: I can't stay on schedule with my high blood pressure meds. My doctor keeps hounding me. Is it so bad not to take them regularly? - Gracie P., Hull, Mass.
A: You can skip a rock, skip school or simply skip for exercise (see iskip.com if you don't believe us). But skipping your meds is bad for your health; it allows your blood pressure to rebound to its previously high, potentially dangerous levels.
Overall, not taking prescribed medications costs the U.S. $177 billion annually in avoidable hospitalizations and other health care costs. Almost 33 percent of folks don't collect their prescribed ...


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Nassau's budget deficit
At a Mineola news conference, Nassau Comptroller George Maragos releases his mid-year report on the 2012 budget, projecting a $45-million deficit unless measures are taken to raise revenue or cut costs. Videojournalist: Ed Betz (July 13, 2012)
Newsday.com now uses Facebook for our comment boards. Please read our guidelines and connect your Facebook account to comment.
Thunderstorms leave downed trees, power outages in Suffolk Police: Woman hurt in 2-vehicle crash Pit masters smokin' on LI Crash on Sunrise Highway shuts roadway Halloween in August Northport PlayStation event lets public play unreleased games One camper's beginning and another's end Turtles released back into the wild in Hampton Bays Osprey untangled from fishing line Lemurs can paint! Car lurches into service garage, knocks another car off lift Famous Montauk eatery sold


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What do you get the toddler who is about to get a little brother or sister? What about a personalized Crayon Case? I made this one for my nephew. Read all about the process HERE in my main blog EvinOK.
2 thoughts on "Crayon Case with Initial Applique"
Great idea! Very nice gift for the big brother.


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Tutoring Services in Texas
Serving Conroe, Kingwood and Houston, TX
Sylvan Learning Center
Sylvan Learning Center is the leading provider of tutoring and supplemental education services to Conroe, Kingwood and Houston, TX students of all ages and skill levels. Our warm and caring tutors tailor individualized learning plans that build the skills, habits, and attitudes students need to succeed in school and in life. Affordable tutoring instruction is available in math, reading, writing, study skills, homework help, test prep, and more at more than 900 learning centers in the United States, Canada, and abroad. We have helped more than 2 million students to discover the joy of learning. Your child's success is our guarantee.
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Call Sylvan Learning Centers today at 281-367-1300 for our Conroe location, 281-361-9253 for our Kingwood location and 281-586-8069 for our Houston location for all your tutoring needs. Please click here to see our video
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The Bulldogs entered the game ranked 20th in the nation in scoring (34.5 ppg), but were limited to a season-low 10 points by UTC. Wise, a native of Lawrenceville, Ga., tallied eight tackles and picked off a pass in the fourth quarter to thwart a Bulldogs' drive inside UTC territory.
It was Wise's first interception of the season and the ninth of his career. He is now tied with head coach Russ Huesman (1978-81) for sixth all-time in career interceptions at UTC.
This is the first Defensive Player of the Week award for Wise. He won SoCon Freshman of the Week honor after picking off two passes in the Western Carolina game in 2010.
Saturday's victory gave the Mocs their biggest road win over a ranked opponent since topping No. 10 Appalachian State in 1983. UTC improved to 2-3 overall and evened its SoCon record at 1-1. The Mocs have this weekend off before visiting Furman on Saturday, Oct. 13. The 1:30 p.m. (E.D.T.) game against the Paladins airs live on ESPN3.
Wofford's Eric Breitenstein was the Offensive Player of the Week, while Appalachian State's Sean Price was the Freshman recipient. Furman's Jerodis Williams was tabbed the Special Teams honoree. The players of the week are selected by the conference office.


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1923 Dodge Brothers. Was a touring car cut down to make a pickup. Runs, but the water pump seal nuts leak. Windshields are good,... More
1964 Dodge Dart GT - real GT. 273 stick car, 273 block, 1 head, no trans, 5.0 bellhousing, trunk full of chrome and pieces,... More
1947 Doge 5 Window Coupe. All original complete car. All window glasses are intact. Engine does not run in current condition. Three speed fluid... More
62 dodge power wagon, good 6 cyl motor, has not run in over 20 yrs ,manual trans. transfer case and 4wd working. needs restoring... More
Dodge 1936 2-door sedan, Model D-2, dry MT car, complete, solid floors, driveline intact, rear trunk, dash, seats, located in MN.... More
1946 Dodge Sedan 6 cylinder flathead, 'Fluid Drive' transmission Suicide doors on rear Complete Clean Title This car was purchased as a project, but it is not going to... More
GREAT STREET ROD/ORIGINAL PROJECT. HAS ORIGINAL ENGINE, TRANSMISSION, AXLES... MOSTLY COMPLETE ... More
1977 Dodge Ramcharger Convertible (1st Generation) Full Time 4 Wheel Drive Original & Only Owner - Custom Order – approximately 171,700 on odometer 360 VE bored... More
1964 Dodge Dart GT Convertible, 50th Anniversary model. After owning my Dart over twenty years, and using it as a reliable 'daily driver' I am... More
1935 Dodge 4 door sedan. Complete body with doors, front sheetmetal, running boards, rear fenders and much more. Has dual sidemount front fenders with... More
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Dodge: 1975 Coronet Brougham.49K, original throughout, including paint and interior. 318, AT, AC and cruise. Exceptional. Rust free. Cold Springs Farm, 717-259-0187, East Berlin, PA... More
FOR MORE INFORMATION ON THIS VEHICLE PLEASE CONTACT CRAIG ON 909 730 1555 MIKE ON 909 644 6220 OR MARCO ON 909 286 8000... More
Civilian production at Dodge was restarted by late 1945, just in time for the 1946 model year. The market was very strong which was... More
1995 Dodge Pickup. This one will stand out in any crowd! It was painted by the late Karl Bernes, renowned custom painter from... More


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Vagif Javadov cancelled out Andrei Arshavin's early goal as a lacklustre Russia side rounded off their Group 4 qualifying campaign with a 1-1 draw against Azerbaijan.
Russia were already resigned to second place following defeat to group winners Germany on Saturday, and coach Guus Hiddink, with six players on yellow cards and an eye on next month's play-offs, fielded an experimental side in Baku. But it was mainstay of the campaign, Arshavin, who broke the deadlock after 13 minutes, tapping in from close range after Azerbaijan goalkeeper Kamran Agaev could only palm Alan Dzagoev's shot into the Arsenal man's path.
Having taken the lead, Russia were guilty of taking their foot off the gas and allowed their hosts to come into the game. A deep free-kick from Vladimir Levin in the 19th minute eluded everyone and Russia goalkeeper Igor Akinfeev had to be alert to turn the bouncing ball over the bar.
From the resulting corner Makhir Shukurov was presented with a sight of goal but mis-hit his shot wide. Azerbaijan came close again in the 28th minute when Aleksandr Chertoganov's stooping header forced a sharp save from Akinfeev at his near post.
Despite Azerbaijan's spell of pressure, Russia remained a threat on the break and came close to doubling their lead three minutes before half-time. A neat combination between Arshavin and Vladimir Bystrov resulted in a delicate lob from the Zenit St Petersburg midfielder that bounced off the top of the crossbar and over.
Three minutes into the second half, Azerbaijan came within inches of equalising when Sergei Ignashevich's hesitant defending allowed Javadov a shot on goal that Igor Akinfeev awkwardly fisted against the crossbar. And moments later Russia were made to pay for their slack defending when Javadov was allowed another sight of goal, catching out Akinfeev with a bouncing shot from 30 yards to level the score.
Hiddink brought on Igor Denisov and the uncapped Aleksandr Bukharov to try to wake his side from their slumber, and Arshavin almost regained the lead for the visitors with a clever turn and volley that was blocked by Agaev.
With 10 minutes remaining English referee Howard Webb awarded Russia a penalty after Dzagoev tumbled under a challenge from Samir Abbasov, but Ignashevich's weak spot-kick was held by Agaev. It summed up a frustrating night for Hiddink's men.


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A medley of Christmas faves in one short piece.
Weaving three favorite Christmas carols together into a work that will appeal to young performers and audiences alike, this piece includes "We Three Kings," "Silent Night," and "Angels We Have Heard on High," all arranged to create some holiday cheer for your next concert. Run time 3m 45s.


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|Pin It
Alexander Henry, Mecca for Moderns, Broome Street 5 Total
Each 1/2 Yard Measures: 18"x 44/45"
You will receive a 1/2 yard of each of the following:
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Fiber Content: 100% Cotton
If you would like to have 1 full yard of each, please enter 2 in the Qty Box.
Yardage is cut in one continuous piece.
Hover over image for a larger, better view.


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Britain's hateful politics
BELFAST, Northern Ireland — The death of former British Prime Minister Margaret Thatcher has prompted reactions from Britain's far left that takes bad taste to new extremes. During its Top 40 music countdown Sunday night, BBC Radio 1 was "forced" to play a seven-second clip of "Ding Dong the Witch is Dead" from the 1939 film "The Wizard of Oz," because Thatcher haters had bought enough copies during a feverish online campaign to bump it to the top of the pop charts. It ultimately reached the number two spot, 5,000 sales short of the top position.
If you think U.S. politics has become too corrosive, consider the British variety. Call it patty cake vs. cage fighting.
"Death parties" have been held across the UK at which anti-Thatcherites celebrated her passing. Anarchists, who demonstrated their hatred for Thatcher over the weekend, plan to join other haters for a demonstration at her funeral on April 17, which has prompted Scotland Yard to make preparations to defend heads of state, or their representatives, along with celebrities against terrorist attack.
A veteran Metropolitan Police officer, Sergeant Jeremy Scott, tweeted that he hoped Thatcher's death was "painful and degrading," adding the world would be a "better place" if Prime Minister David Cameron and some of his cabinet members were also dead. Scott has since resigned.
The Daily Mail reported that a drama teacher named Romany Blythe called Baroness Thatcher a "despot" and said: "They danced in the streets when Hitler died, too."
Some students who attended death parties were too young, or not yet born, to be aware of the Thatcher years. The Daily Telegraph quoted 21-year-old Aamna Mohdin, a biology student at Queen Mary, University of London, who called Thatcher a "terrible person" and a "draconian woman" who did nothing for women or feminism.
These are the products of "higher" education. One student who attended a death party was quoted as saying she didn't become a liberal until she went to university. No surprise there.
Why such visceral reactions to a woman who served her country for 11 years as prime minister? For many, government is a drug to which they have become addicted. They need the drug to survive. Margaret Thatcher tried to break that addiction and get her people to support themselves. Anyone who suggests it is possible even desirable to break the government "habit" becomes the target of the "addicts" and their enabling politicians, both in life and now in death.
The British press has reported on families in which several generations have been on "benefits" with no expectation of ever working, and no motivation for finding work. They are offended by suggestions they look for a job.
Thatcher sought to break that cycle and in so doing angered many who thought it their "right" to be on the receiving end of other people's money. The debate in the UK mirrors that taking place in the United States as too many politicians, reluctant to tell anyone "no" for fear of losing votes, indulge people in their social and economic addiction to government.
The battle being fought in both countries is between those who value the individual as supreme and others who regard the state as supreme. In the UK and U.S., government has exceeded its boundaries and just as last winter's floods in the UK have caused severe damage, there has been similar damage to liberty and the promotion of capitalism in both countries.
The Cameron government has cautiously tried to emulate Thatcher in its reform attempts. These include the costly and underperforming National Health Service — a preview of coming attractions if Obamacare is fully implemented in the U.S. next year.
If Cameron succeeds, the left will probably celebrate his eventual demise, too. Such is the poisoned well of British politics.
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Top 10 Japanese Inventions
Japanese tech companies are better known for improving upon foreign inventions, but there have been plenty of significant technologies to come out of Japan in the last 50 years. Here are ten of the best.
10. The Flat-Panel Display
The first commercially available flat-panel display of any kind could be found on the Sony Watchman FD-210, a pocket television released in 1982. The FD-210′s display was a paltry five centimeters, but the technology involved was impressive and paved the way for the home flatscreens we see today. The first LCD and Plasma televisions were also created by Japanese companies, Sharp and Pioneer respectively.
9. The Floppy Disk
The floppy disk is counted among the many inventions of the colorful Yoshiro Nakamatsu, AKA Dr. NakaMats. The details behind the invention, and how the technology wound up in IBM's hands, are shrouded in mystery, but Nakamatsu was awarded a patent for the base technology behind the floppy disk in 1952, long before they went public. While floppy disks are now considered a relic, they were the primary portable storage medium for computer users everywhere for a good three decades.
8. The Digital SLR Camera
The first known digital camera with single-lens reflex elements was the Sony Mavica, revealed to the public in 1981. However it wasn't until 1999 and the release of the Nikon D1, that Japanese-developed, full-fledged digital SLRs started to supplant 35 mm film as the popular choice among professional photographers, thanks to their superior combination of speed, ease of use, and image quality.
7. The Video Cassette
The video cassette and VCR, both Sony creations made available in 1971, represented the start of a new era in home entertainment. Thanks to the video cassette, consumers were finally able to watch films at home, and at a time of their choosing. Studios benefited enormously too, as they were granted a new revenue stream in the form of the home video market, which eventually overtook the box office in value.
6. The Camcorder
As hard as it is to believe now, the process of on-location video recording used to require at least two people. Prior to the 1980s TV news crews used video cameras – that is, the devices that were actually used to shoot video – with separate recording units. The earliest portable video recorders still had to be connected to the camera via a cable, which limited their utility. With the Sony Betacam, released in 1982, a video camera and video recorder were combined into a single device for the first time. The camcorder, as it came to be known, revolutionized journalism and
filmmaking, and eventually brought video recording home.
5. The Pocket Calculator
Although the first so-called 'compact' calculator was also made in Japan, it wasn't until 1971, birth year of the Busicom LE-120A, that truly portable calculators became widely available. 1978′s Sharp EL-8086 was the first solar-powered calculator, and this further extended the reach of the device, helping to conserve battery and brain power around the world.
4. The Portable Music Player
Before the iPod, the Sony Walkman was synonymous with music on the go. While technically not the world's first portable cassette player, the Walkman was by far the most successful, bringing the concept of portable music to the masses. Sony introduced a number of new features along the line, including a recording function (still sorely missing from modern music players!), and playback of other media, like CDs (1984′s Discman), and even TV and video cassettes (with the Video Walkman, released in 1989). Just try to imagine what the world would be like without portable music players.
3. The Quartz Wristwatch
Released in 1969, the Seiko Astron was the world's first quartz wristwatch. Quartz technology represented a substantial upgrade over old-fashioned mechanical watches, as it eliminated the need for easily damaged moving parts, while keeping time more accurately than previous watches. Quartz remains the standard for wristwatches to this day.
2. The High-Speed Passenger Train
The 12-car 0-Series Shinkansen bullet train, which ran from 1964 to 2008, was the world's first high-volume, high-speed passenger train. Superior rail transport was one of the major factors that helped to power Japan' economy to number two in the world, and the design of the early Shinkansen influenced overseas engineers as well.
1. The Compact Disc
Created jointly by Sony and Philips in the late 1970s, the compact disc, and the Sony-developed CD player, are perhaps the most important technologies to come out of Japan. Originally intended strictly as a replacement for vinyl records, the CD proved useful as a general data storage medium in the form of the CD-ROM and then the CD-R. Its successor technologies, the DVD and Blu-ray disc, are also both joint Sony/Philips creations. The optical disc remains one of the modern world's most ubiquitous inventions.


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Pilgrim Center of Hope
A Catholic Evangelization Ministry for the Archdiocese of San Antonio, the Pilgrim Center of Hope serves the community through Conferences, retreats, Catholic media programs and by organizing pilgrimages, journeys of faith, to the Holy Land as a means for persons seeking spiritual renewal and solidarity with the universal church.
Monthly Archive for March, 2012
7 Practical Principles for Discerning God's Will in Our Lives
It's a common question: "What does God want?" How do we know? Lent gives us the perfect opportunity to learn the answer, as we enter 'into the desert' with Jesus, listening to God's voice in prayer and penance. Here are some practical principles (based on Peter Kreeft's book "Making Choices") to help you discern God's […] [Read More]


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March 19, 2013
ATHENS, Ga. - University of Georgia Athletics now offers fans the "Tuesday Ticket Deal of the Week" - a ticket discount offered every Tuesday for tickets to an upcoming home event.
Today only (expires 11:59p.m.), tickets for Friday's Baseball game vs. Alabama are just $2 when using the promotional code listed below. Great opportunity to enjoy the game with family and friends.
Fan Up Tuesday Ticket Deal of the Week
UGA Baseball vs. Alabama
Friday, March 22 (7:00p.m. first pitch)
$2 tickets (General Admission seats available)
To purchase tickets at this discount, please visitUGA online ticket officeand enter the promo codeBSB19. Tickets are for reserved seats and subject to availability. The promotional code offerexpires Tuesday, March 19 at 11:59p.m..
Fan Up Tuesday Ticket Deal of the Week offers are only availableonlineand not available by phone or in person. Be sure to check each Tuesday morning for the Fan Up Deal of the Week.


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David W. Mullins
- BS, Virginia Tech
- PhD, Virginia Polytechnic Institute and State University, Blacksburg, VA
- BS, Virginia Polytechnic Institute and State University, Blacksburg, VA
- BS, Virginia Polytechnic Institute and State University, Blacksburg, VA
- Postdoc, University of Virginia
- Phone: 4349241706
- Email: email@example.com
- Website: http://myprofile.cos.com/dmullins
Research Interest(s)
Immunotherapy; Tumor Immunology
Research Description
The Mullins Research Lab, a component of the Human Immune Therapy Center, combines basic science research methods with translational strategies and bioinformatics to explore improved immunotherapy and to understand the immunologic response to cancer in humans. The basic premise of tumor immunotherapy is that the immune system can be stimulated to affect an immune response to specific antigens on autologous tumor cells. Like the immune reactions to intracellular pathogens, effective anti-tumor responses are often mediated by CD8+ cytotoxic T-lymphocytes (CTL). Unlike standard vaccinations against infections pathogens, tumor vaccines are not routinely provided as prophylaxis, but rather, as a means of therapeutic intervention. It is therefore likely that endogenous immune responses directed against tumor-associated antigen will have already occurred prior to vaccination, leading to the formation of tumor-specific memory T cell populations. Therefore, successful anti-tumor vaccination will likely require the reactivation of memory T cells, induced in the context of chronic antigen stimulation, rather than the induction of "new" memory T cells as would occur in a prophylactic setting. To date, the seminal research on memory T cell induction, activation, and function relies on infectious models of acute infection. Therefore, an opportunity exists to make significant advances in the understanding of immune function in the context of cancer, and to develop therapeutic strategies to appropriately and efficiently stimulate a patient's memory T cells to infiltrate and kill tumor. Current Research Efforts The goals of my research program are to generate new knowledge pertaining to the CD8+ memory T cell response to cancer, and to translate these discoveries onto clinically-applicable therapies. Therefore, the research enterprise consists of interrelated areas of study involving the memory T cells, including:
- Evaluation of the CD8 memory T cell response, with emphasis on molecular mediators of cell migration (chemokine receptor and integrin expression) in the context of cancer and anti-cancer immune therapy. We are focusing on two aspects of T cell migration: expression of homing receptors by the T cells (Mullins Lab), and expression of the chemo-attractant molecules (chemokines) in tumor (in collaboration with the labs of Drs. Craig L. Slingluff, Jr., and Robert M. Strieter). We previously identified an association between clinical outcomes of patients with advanced metastatic melanoma and CD8 T cell expression of the chemokine CXCR3, suggesting that vaccines which specifically induce CXCR3 (or potentially other similar molecules) on T cells may provide a significant therapeutic advantage. Currently, using murine models and human isolates, we are evaluating therapeutic strategies to modulate CXCR3 on tumor-specific T cells. Simultaneously, we are working with Drs. Slingluff and Strieter to evaluate the expression of chemokines in the tumor microenvironment and test the efficacy of various biological agents for the site-specific induction of chemokine production. Collectively, these data will form the foundation for a clinical vaccine trial in 2009-2010.
- Identification of genes and pathways that differentiate productive and non-productive immune responses to cancer. In an ongoing project led by the lab (in collaboration with Bill Knaus and Irene Mullins from Public Health Sciences, Victor Engelhard from Microbiology, and Craig Slingluff from Surgery), we are evaluating immune isolates from patients with divergent clinical outcomes with advanced metastatic melanoma. To date, we have identified gene expression profiles in CD4 and CD8 T cells that correlate with enhanced immune response and survival. These data provide the underpinnings for a prognostic instrument (patent pending) and novel targets for immune intervention in the treatment of melanoma.
- Identification and characterization of immune escape mechanisms that facilitate cancer progression in the presence of tumor antigen-specific CD8+ memory T cells. While studies of immune cells are critical for their understanding of tumor immunity, studies of the tumor cells themselves are providing new clues as to how cancer evades immune responses and spreads throughout the body. For example, our lab has demonstrated that melanomas secrete proteins from the tumor necrosis factor superfamily. These molecules are normally produced only in growing bone, where they prevent immune rejection of the newly-formed osteoblasts. Production of these proteins by melanoma may afford the tumor significant protection against immune defenses and simultaneously promote metastatic dissemination. These studies may provide new insights into the early detection of metastatic melanoma as well as new targets for therapeutic treatment of melanoma.
Selected Publications
- Dengel L, Norrod A, Gregory B, Clancy-Thompson E, Burdick M, Strieter R, Slingluff J, Mullins D. Interferons induce CXCR3-cognate chemokine production by human metastatic melanoma. J Immunother. 33(9): 965-74. PMCID: NIHMS253549
- Iype T, Sankarshanan M, Mauldin I, Mullins D, Lorenz U. The Protein Tyrosine Phosphatase SHP-1 Modulates the Suppressive Activity of Regulatory T Cells. J Immunol. 185(10): 6115-27. PMCID: PMC2974050
- Mullins D, Engelhard V. Limited infiltration of exogenous dendritic cells and naive T cells restricts immune responses in peripheral lymph nodes. J Immunol. 176(8): 4535-42.
- Slingluff J, Chianese-Bullock K, Bullock T, Grosh W, Mullins D, Nichols L, Olson W, Petroni G, Smolkin M, Engelhard V. Immunity to melanoma antigens: from self-tolerance to immunotherapy. Adv Immunol. 90 243-95.
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