text:
A tow truck was set ablaze Jan. 17 in an apparent case of arson, Island Lake police announced. The fire, started by a road flare placed inside the truck, was discovered about 11 p.m. at a business on the 200 block of West State Road, police said. The truck was destroyed, and damage was estimated at more than $15,000, police said. Anyone with information about the fire can call Island Lake police detective Barry Huedepohl at (847) 526-2100.
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As we approach the winter solstice, less than three weeks away, the shortest days of the year are upon us.
It can be a discouraging time for people who want to get outside and exercise at a time of year that you need it more than ever.
For me, part of that reason is just safety, particularly when darkness combines with the inattentiveness of text messaging and other distractions.
And while the ideal this time of year is to carve out some time at lunch to exercise at high noon, and get a little mood-lifting sunshine, the reality for most is that we're doing it in the dark.
So with that fact in mind, it's time to assess a few things, from running, walking and biking defensively to taking some practical second steps with clothing and identification.
The big D
When I say "defensively," I take this approach: When I'm running in the dark, I assume every driver doesn't see me. I forget the whole "pedestrian has the right-of-way" mentality.
Be hyper-alert. Slow down a bit. Run or walk against traffic. And get rid of the ear buds.
While I'm not a fan of running with a cell phone, it also is a good idea in case something happens.
And just in case the unimaginable happens, have identification on you. The go-to is Road ID, which, by the way, is a great stocking stuffer.
Light it up
Long ago, I can remember my sister buying me one of those reflective vests for running at night, but I didn't like it and never wore it.
And while a reflective vest is probably a good idea, there are plenty of other reflective gear and lighting available these days that isn't quite, well, so geeky.
Take inventory of what you've got and add to it.
The full arsenal for running, biking and walking should include small but bright LED lights, head lamps, reflective bands (one of my favorites wraps around a wrist or ankle). and reflective and fluorescent clothing.
I could go into specifics, but it would read like a commercial.
Go to your local running and biking stores — Charleston has plenty — so that you can see what your buying and support local business.
Seek light
Yet another option, instad of running on a dreaded treadmill, is to find well-lighted, protected places to run. The Cooper River bridge pedestrian lane is one of the safest places I know to run outdoors at night, but stay out of the bike lane. Public outdoor tracks when recreational activities are going on and lights are turned on is another option.
Don't forget, after Dec. 21, the days start getting longer and it will be just a few months before we don't have to worry about the issue.
Reach David Quick at 937-5516.
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subset: commoncrawl


text:
Below is the poem entitled Circle of Life which was written by poet
long. Please feel free to comment on this poem. However, please remember, PoetrySoup is a place of encouragement and growth.
Read Poems by
Cory Long
Life is a circle that never ends.
Blessed with joy as a baby is born
Ending in sorrow and pain for most.
A land full of mystery lies in your way.
Where anything is possible if you believe.
Some day's life feels strange and unfamiliar.
Like you don't belong where you're at.
Other days nothing will hold you back.
Children grow up learning lessons they can keep.
Teenagers fall in love and feel what a broken heart is.
Young couples marry and vow forever before god.
Divorce happens and some marriages fall apart.
Friends are made and some are lost
Old couples hold each other's hearts.
Then comes the day when life comes to an end
And a new circle of life begins.


text:
You can't like your own messages.
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text:
Originally posted by tangonine
Originally posted by ThePublicEnemyNo1
Originally posted by TXRabbit
Don't you guys get it?
If I$rael or anybody else in the region didn't have nuclear weapons/programs, there wouldn't be anything to whine or complain about.
When there's nothing to whine or complain about, I$rael is no longer a victim.
When I$rael is no longer the victim, they don't get paid.
When I$rael doesn't get paid, neither do the US politicians who support them (campaign contributions, outsourcing/contractual agreements etc)
Spoken like a pro
Spoken like an anti-Israeli propagandist.
Originally posted by tangonine
The difference is that Israel has used its nuclear capability not as a threat but as a deterrent. Iran explicitly threatens the states of Israel on a weekly basis.
If you can't differentiate between the two then, well, (comment that would get me mod attention).
Logic. Try it.
You really need to remove your "rose coloured glasses" when talking about Israel.
Originally posted by dontreally
A bunch of crazed Islamists come together and essentially say to Israel "hey, come join us in our nuke-free summit. No? Yea, we know you have nukes to protect yourself from us, but still; it's no good for us!"
You really need to remove your "rose coloured glasses" when talking about Israel.


text:
Register now for free, or sign in with any of these services:
Want to set your local edition?
Select an edition for more focused local news coverage when you visit mlive.
Don't worry. You can change this setting at any time to another local edition.
By the way, I'm not buying the put on weight purposely thing.
Added strength + weight = Good
300 lbs + more weight = Pre-Diabetes
Adding Reif to the OT group made the unit so much better at both T and G. Center is the next piece to puzzle.
Raiola is now to the Lions what Brandon Inge was to the Tigers - thanks for battling it out in the down years but we're hungery for championships now!
My dilemma:
1.) It's tough to develop the young guys if they don't see the field. Tuesday, Wednesday, Thursday doesn't always show you the player you get on Sundays.
2.) We're good enough to win now so get all the talent we can and make them earn the playing time. Seems very logical.
I see the Lions keeping 6 corners no matter what.
The extra spot will come from only keeping 2 quarterbacks - a popular trend in the NFL as of late.
Keep 6 because at least 1 will be on IR before week 6.
Great! I already have a Ronnell "The Hammer" Lewis jersey.
It says 'Bailey' on the back of it though.
Besides, this is Michigan.
Remember that shoulder injury? If Jenoris plays his cards right, he won't have to worry about legal issues surrounding his trivial habit... only league testing.
I would have taken Jenkins last year at #13 had he come out of school early. I'll gladly take him at pick #23 this year.
We've all seen it happen or made the mistakes ourselves hanging out with the wrong crowd. I'm willing to bet that VandenBosch, Suh, Delmas, Stafford and the rest of the crew will have a greater POSITIVE influence on a young man like Jenkins, than Jenoris could possibly bring those guys down.
I'm a Lions fan living in Indianapolis and I am very excited about signing Jacob Lacey. Regardless of stats, ratings, etc. - This guy is a player! He has the undrafted chip, high motor attitude that is rare to see in a defensive back.
Don't be surprised if he works his way into a starting spot this season and becomes a fan favorite.
Would like to see Delmas back on the field... any expectation for his return?
This would be a good time of the year for our team to come around to full strength, runningbacks aside. Fairley, Delmas, all of the backers and corners - let's get our D back to the D we saw earlier this season on a Monday night vs. Chicago.
Dude from Saginaw -
Asking for help from foreign countires in what way? I don't get it.
I read some of your other posts and you have some really solid points. But they're mixed in with some outlandish ones as well. I got a good chuckle out of those, hoping they were sarcastic. I mean, 'get rid of child labor laws' - come on, guy.
Out of all of those names... I want Delmas back on the field.
Even if we had a "silver bullet" plan, the same issues will arise. We can write theories, change distributions, redraw district lines, offer mulitple choices and every other idea under the sun but the bottom line is this...
Until there is a cultural change, blueprints are meaningless. Personal responsibility and a desire for education is the cornerstone of this issue. That is the broken down starting point... not 19 billion dollars. From there, ALL of the frontrunning ideas could work.
Let's quit wasting time, money, and effort looking for a bandaid that will only last for so long. Instead, invest those resources to engage children. It all starts with them.
This is America and no matter what town, city, cornfield or ghetto a child may grow up in - they can truly go as far as their desire will take them.
coolrunnings - This is a unique situation with it being a change of possession. 22 players arguably have reason to be on the field once the whistle had blown.
Stafford's finger...
Calvin's head...
Who's running the ball this week?
Is Leonard Davis getting ready to play or will Stafford (or Hill) be throwing the ball 70 times this Sunday?
These are just a few things that I expected to see some articles written on. Maybe I need a new inside source!!!
I also like the pick-ups at this point in the season. But I am questioning Kevin Smith over Aaron Brown. Brown replaces Jahvid's explosiveness better while K34 is a much better pass protector.
I'm hoping that is a sign that Jahvid will likely be back this season.
Wishing you the best, JC.
Those guys are old news.
A good place to start gaining respect as a program would be a MAC Championship.
"This isn't the unemployment line, is it?" or "Do elves get benefits?" or "Same as last year, please. And the year before that. And the year before that..."
Landon Johnson - Jack of all trades, master of none.


text: Memorial Day 28 Monday May 2012 Posted by comfortablydomestic in Random Musings ≈ 1 Comment Tagsgiving thanks, housewife, memorial day, mother of boys FDR Memorial, Washington D.C. (Photo credit http://www.superkids.com/) We remember those who gave all so that we can be free. Thank you. Share this:Print FriendlyEmailShare on TumblrLike this:Like Loading... Related


text:
Ted Kirkpatrick
I was informed of this awesome site by some fans who suggested I post - so here I am and here's some stuff... I have a new solo album coming out May 2010 - you can hear a track here:
NEW ALBUM TRACK: http://tourniquet.bandcamp.com/
BIO: http://www.tourniquet.net/bio/index.php?id=1
PAISTE: http://www.paiste.com/e/endorser_det...endorserid=836
VIC FIRTH: http://www.vicfirth.com/artists/prof...ile.php?id=697
DW: http://dwdrums.com/artists/roster.asp
FACEBOOK: http://www.facebook.com/pages/Tourniquet/56372703466
TOURNIQUET: http://www.tourniquet.net/home/
YOUTUBE: http://www.youtube.com/results?searc...rkpatrick&aq=f
Re: Ted Kirkpatrick
One of the greatest drummers ever! Huge fan, such a shame he isn't recognized more out of the christian metal music scene.
Re: Ted Kirkpatrick
Ted, welcome! I'm glad things continue to go strong for you!!
Re: Ted Kirkpatrick
Hi Ted,
Good to see you here. I just joined this site. Do you play left handed? I noticed by the pic, that the toms are in reverse order for a right handed drummer. My former drum teacher, Mark Rogers (Newworldson / LMT Connection) is a left handed drummer.
Re: Ted Kirkpatrick
Hey Bro,
I have to say you are my biggest musical influence. I've had the good fortune of meeting you on several occasions and my band opened for Tourniquet back in 1993. Thank you for being such a blessing to my life.
Re: Ted Kirkpatrick
dude youre one of my favorite drummers. you completely changed christian metal for me. im 17 and my dad showed me tourniquet back like 5 or 6 years ago. my mind expanded. you sir rule
Re: Ted Kirkpatrick
Thanks for the kind words. We are now accepting preorders for my new technical drumming solo project IN THE SHADOW OF THE MASTERS. The album is finished and scheduled to go to manufacturing on June 8. It should be available shortly after. In honor of my endorsements, the first 100 orders for the CD will get THREE free bonuses! From PAISTE a PAISTE ...cymbal keychain. From DW a DW drum key keychain, and From VIC FIRTH, a new model VIC FIRTH drumstick keychain all FREE with your CD order. Offer limited to the first 100 orders, so act fast http://tourniquet.net/home/
9 tracks, over 40 minutes of drumming to classical masterpieces from Bach, Mozart, Beethoven, Chopin, Paganini, and other great composers. Listen to a track here: http://tourniquet.bandcamp.com/
Re: Ted Kirkpatrick
Hey drummers - my new album IN THE SHADOW OF THE MASTERS has been released. I had a blast making it. You can hear/buy it here: http://tourniquet.bandcamp.com/
Also available on itunes, Amazon, Napster, etc. - let me know what you think!
"To me, the fantastic music of the classical masters is in a totally different realm - there simply is no other music to compare it to. I believe it was a time in history that will never be repeated - kind of like when dinosaurs roamed the earth. In drumming to these timeless works as with any music, I always strive to treat the drums as a musical instrument - not just a noisy time keeper. These are some of my favorite composers with some of their most brilliant works." Ted
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text:
The global burden of migraine: measuring disability in headache disorders with WHO's Classification of Functioning, Disability and Health (ICF)
- M. Leonardi,
- T. J. Steiner,
- A. T. Scher,
- R. B. Lipton
- … show all 4 hide
This overview of the published epidemiological evidence of migraine helps to identify the size of the public–health problem that migraine represents. It also highlights the need for further epidemiological studies in many parts of the world to gain full understanding of the scale of clinical, economic and humanistic burdens attributable to it. This paper presents some of the work on migraine undertaken by the World Health Organization (WHO) in the Global Burden of Disease study conducted in 2000 and reported in the World Health Report 2001. Migraine was not included in the first Global Burden of Disease 1990. The paper also discussed the measurement of disability attributable to headache disorders using WHO ICF Classification. Using disabilityadjusted life years (DALYs) as a summary measure of population health (which adds disability to mortality), WHO have shown that mental and neurological disorders collectively account for 30.8% of all years of healthy life lost to disability (YLDs) whilst migraine, one amongst these, alone accounts for 1.4% and is in the top 20 causes of disability worldwide. This information is combined with the increasingly widely accepted belief that disability and functioning are relevant parameters for monitoring the health of nations and that there is an increasing need to measure them. WHO's Classification of Functioning, Disability and Health (ICF) provides a model of human functioning and disability, as well as a classification system, that allows us to highlight and measure all dimensions of disability. ICF applied to headache disorders allows comparability with other health conditions as well as evaluation of the role of the environment as a cause of disability amongst people with headache. Migraine causes a large propotion of the non–fatal disease–related burden worldwide.Our kowledge of headache related burden is incomplete and it is necessary to add to it epidemiological studies in many parts of the world and to combine this with measurements of disability using both DALYs and WHO 's ICF Classification. The work described here has been the base for the Global Campaign against Headache disorders: "Lifting the Burden", launched in 2004 jointly by WHO, IHS (International Headache Society), WHA (World Headache Alliance) and EHF (European Headache Federation).
- Title
- The global burden of migraine: measuring disability in headache disorders with WHO's Classification of Functioning, Disability and Health (ICF)
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
- Journal
The Journal of Headache and Pain
Volume 6, Issue 6 , pp 429-440
- Cover Date
- 2005-12
- 10.1007/s10194-005-0252-4
- Print ISSN
- 1129-2369
- Online ISSN
- 1129-2377
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Keywords
- Burden
- Disability
- Migraine
- Epidemiology
- Industry Sectors
- Authors
- M. Leonardi (1)
- T. J. Steiner (2)
- A. T. Scher (3)
- R. B. Lipton (4)
- Author Affiliations
- 1. Scientific Direction, Italian National Neurological Institute "Carlo Besta", Via Celoria 11, I–20133, Milan, Italy
- 2. Division of Neuroscience and Mental Health, Imperial College London, Charing Cross Campus, St. Dunstan's Road, London W6 8RP, UK
- 3. Department of Preventive Medicine and Biometrics, Uniformed Services University, Room A 1039 C, 4301 Jones Bridge Road, Bethesda, MD 20892, USA
- 4. Departments of Neurology, Epidemiology and Social Medicine, Albert Einstein College of Medicine, Room 332, 1165 Morris Park Ave, Bronx, NY 10467, USA


text:
Utah State Football Moving In The Right Direction Under First-Year Head Coach Matt Wells
Matt Wells, who has spent the past two years on staff at Utah State, including serving as offensive coordinator during USU's historic run in 2012, was hired on Dec. 20 to lead the Aggie football program as it transitions into the Mountain West Conference.
Dave Scholz is in his second season as Utah State's strength and conditioning head coach and in his fifth year overall with the Athletics Department.
Scholz came to Utah State after spending the 2012 season in the National Football League as a strength, nutrition and conditioning assistant with the San Francisco 49ers. In his position, Scholz was responsible for the programming for quarterbacks and kickers as well as all the nutritional aspects of the team, including meal planning. Scholz spent the 2011 season as the 49ers strength and conditioning intern.
Prior to joining the 49ers, Scholz served as the assistant strength and conditioning coach at Utah State for three years (2008-10), where he assisted in all matters of football and served as the head of sports nutrition. He also was the lead strength and conditioning coach for softball and volleyball.
From 2006-08, Scholz was a graduate assistant at Utah State, where he worked alongside current 49ers head trength and conditioning coach and former USU head trength and conditioning coach Mark Uyeyama. During the summer of 2006, Scholz was a strength and conditioning intern at Arizona State.
Scholz has also earned his CSCS Certification from the NSCA, Precision Nutrition Certification, ISSA Sports Nutrition Certification, BioSignature Modulation and PICP Levels I & II Certification.
Scholz, who played football at Wisconsin-Eau Claire from 2002-03, was also a national level powerlifter at the 275-pound class. He earned his bachelor's degree in exercise fitness from the Wisconsin-Milwaukee in 2004, and went on to earn his master's degree from Utah State in health, physical education and recreation in 2008.
Scholz is married to the former Kara Krupski.
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text:
Below is the poem entitled Diamonds in Your Eyes which was written by poet
Galinta. Please feel free to comment on this poem. However, please remember, PoetrySoup is a place of encouragement and growth.
Read Poems by
Leonora Galinta
A poem inspired by the contest theme. thank u.
Become a
Premium Member
and post notes and photos about your poem.
You titillate my senses
Every time you stare at me,
I feel losing my balances
All gems in your eyes I see.
You possess tantalizing eyes,
Like diamonds in the sky;
Don't attempt to look at me thrice,
You're in love…you can't deny.
I'm completely captivated
You know my only weakness
In your wooing you succeeded,
You're getting my final "yes".
As we hold each other's hand,
Happily gliding on snow;
Kissing me all around,
Diamond remnants-all aglow.
Dec. 31, 2013 5.15pm
by Leonora G.
Fourth Place
Contest: A Diamond Remnants
Judged: 1/14/14
Sponsor: Poet Gail Angel Doyle
I will be closing the year 2013 with a romantic poem;))). Happy New Year 2014 to all! Wishing you all the best of HEALTH, LOVE, PEACE, HAPPINESS AND SUCCESS!


text:
Eindhoven, The Netherlands and Baldwin Park, California - Royal Philips Electronics (AEX: PHI, NYSE: PHG) today announced that the U.S. Patent Office has issued a patent to Philips for its innovative Helios® xenon lamp technology. Designed as direct replacements for standard xenon lamps in film cinema applications, Helios lamps can provide up to 30% more light on the screen with no reflector or lens changes and no lamp house modifications. Helios lamps are available in a wide range of wattages and configurations to fit all leading film projectors.
Helios lamps can be used in two ways to reduce an exhibitor's total cost of ownership:
- Provide equivalent light on the screen using a lower wattage Helios lamp. For example, a Helios 4.2 kw lamp running at 4.2 kW can achieve the same light output on the screen as a 5 kW or 6 kW standard lamp running at full power. This provides lower energy costs and cooling requirements and allows the use of a lower cost lamp.
- Provide more light on the screen at the same power consumption. For example, a standard 3 kW can be replaced with a Helios 3 kW lamp running at 3 kW and up to 30% more light will be available on screen. This provides an easy way to upgrade projection equipment without expensive modifications.
Helios lamps are already in wide use by major film exhibitors around the world.
The complete Philips Cinema Xenon lamp range will be displayed at ShoWest, Philips booth #1216-1218. ShoWest will be held from March 30th until April 2nd at Bally's & Paris in Las Vegas.


text:
UE offers tours to potential students
At the University of Evansville students don't get lost in the crowd, they're not just a number and faculty takes a vested interest in their success, according to Shane Davidson, UE vice president for enrollment services.
A campus visit is vital when it comes to the college choice process, and despite always welcoming potential students to tour throughout the year, Davidson encourages young adults to take advantage of the chance to visit UE next week during the third annual Indiana Private College Week, proclaimed July 22-26 by Gov. Mike Pence.
UE will join Indiana's 30 other independent higher education institutions, from South Bend to Indianapolis, that will offer daily campus tours. UE's tour times are 10 a.m. and 1 p.m., followed by sessions with admission counselors.
"For those students that are going to be seniors this next academic year, now is definitely a great opportunity to visit your top college choices before your academic year starts," Davidson said. "Because once a school year starts, students get so busy with cocurricular and extra curricular activities that sometimes makes a campus visit become a little bit more difficult."
UE, a private, liberal arts-based university, has a full-time undergraduate enrollment of around 2,400 with a student to faculty ratio of 13 to one, according to the Independent Colleges Indiana (ICI) website, the nonprofit association that represents the state's 31 private nonprofit colleges and universities. UE's student body represents 42 states and 46 countries. Tuition and fees at UE for the 2012-13 school year were $30,556; and room and board was $10,010, the ICI website reports. However, 99 percent of students receive financial aid.
Other ICI member schools include Butler University, Franklin College, and Oakland City University. The association promotes private schools with their financial aid opportunities and small class sizes. ICI campuses enroll 20 percent of the state's undergraduates and annually award 35 percent of all bachelor's degrees in Indiana.
"Small class sizes are very important to the over all learning experience," Davidson said. "Here at UE students are going to be taught by faculty who hold the highest degree in their field ... and because of that class size, this gives an opportunity for the student to know the faculty member by name, faculty are going to take a vested interest in the student — whether they're coming to class, how they're doing on exams — it just really enhances the learning environment in a setting that promotes learning."
Not-so-common benefits at UE include faculty members offering home and cellphone numbers to be as accessible as possible, Davidson said. And other universities offer study abroad programs, but Davidson said they don't "really have a program that offers the total experience that we do in Harlaxton, UE's British campus. Fifty-two percent of UE students study abroad one semester."
Another benefit for possible UE students that have yet to make their college choice for fall 2013, is UE's tuition freeze that states it won't increase for those students' four-years of schooling.
"Students and families discover through visiting that Indiana private colleges are within reach, financially and otherwise ... We want this week to be a gateway to discovering that dream realized," Richard L. Ludwick, president & CEO of ICI, said in a news release.
To schedule a visit at UE, advance registration is encouraged but not required, contact the Office of Admission at 800-423-8633, ext. 2468, or email@example.com. Students aged 16-20 will have the chance to enter a drawing for one of three Amazon Kindle Fires. For more information on Private College Week and participating universities, visit www.icindiana.org.
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Need Help? Call us at 1-877-304-7771.
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text:
Hang tight!
Recipe by Ginga
"This is a great winter cake! While hot, add a scoop of ice cream to melt with it. Guaranteed a winner!!"
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1 cup
all-purpose flour
2 teaspoons
baking powder
2/3 cup
white sugar
2 tablespoons
unsweetened cocoa powder
1 teaspoon
1/2 cup
2 tablespoons
vegetable oil
1 teaspoon
vanilla extract
1/2 cup
chopped walnuts
1 cup
brown sugar
1/4 cup
unsweetened cocoa powder
1 1/2 cups
boiling water
This is a true pudding cake that was popular in the 1980's and 1990's. Its not meant to be turned out onto a platter but it is meant to be sponed out into a dish and topped with ice cream or whipped cream. Its delicious.
I wish I could give this recipe a fabulous review, but I can't. Sounds delicious, but it came out very runny. Not really pudding,really, just used it as a chocolate sauce over the cake part. Not a super recipe, but the kids enjoyed it.
35 Ratings
I'm giving this a four as the taste was good, but man, it was a runny mess. Do not, I repeat, do not invert cake to a platter to serve. I had a placemat underneath thankfully, but the pudding-ness ran all over it. I would make again (great chocolate fix), but I would just dish it out from the pan itself and serve with vanilla ice cream or whipped cream. I kept putting the cake back in the oven thinking it just needed more time to bake, but that wasn't the case. I would rate this five stars if not for the consistency- but it isn't called "Chocolate Fudge PUDDING (Cake)" for nothing. Expect more pudding than cake, and you will be very pleased. :)
Hey guys, This is meant to be eaten cobbler style..served hot in a bowl with ice cream on top. If it isn't a little runny you will lose the hot fudge syrup kick. Try it again with that in mind :0)
We called this "Magic Chocolate Cake" because the ingredients reverse in the oven. The dry bottom and wet top make a fabulous pudding on the bottom and a brownie-like cake on top. It's a family favorite and absolutely wonderful - alone, but especially with vanilla ice cream!
This is a nice pudding cake and better eaten hot with ice cream. For reviewers that complained about it being runny that is the way it is supposed to be: cake on top and a sauce on the bottom. Do not try to put on a plate - just spoon it out of the dish.
I like this recipe because it's easy and you get your cake and hot chocolate sauce all in one easy step. Serve warm with vanilla ice cream for a nice treat.
best cake ever
* Percent Daily Values are based on a 2,000 calorie diet.
Glendora's Chocolate Fudge Pudding (Cake)
Serving Size: 1/6 of a recipe
Servings Per Recipe: 6
Amount Per Serving
Calories: 385
Calories from Fat: 112
Hard to believe, but many kids will be back in school at the end of the month. Get ready.
You won't believe all the things you can do with cauliflower. It's a great low-carb option.
Delicious recipes, party ideas, and cooking tips! Get a year of Allrecipes magazine for $7.99!
See how to make moist, rich chocolate cake.
Make rich and impressive single-serving chocolate cakes.
See how to make a tasty flourless chocolate cake that's high protein.


text:
About Brussels
Headquarters of the European Union, Brussels is known as the Capital of Europe, and its cosmopolitan flavour, vibrant art scene and rich culture ensure it lives up to the title. From the iconic Atomium to the La Monnaie and celebrated traditions, like the stunning Flower Carpet, Brussels is a city everyone can enjoy.
Entertainment and attractions
Visit the Atomium, one of Brussels most popular landmarks and an architectural spectacle, built for the 1958 World's Fair and designed based on the structure of an iron molecule. Take in the panoramic view of the surrounding area from the topmost sphere, which overlooks Mini-Europe, located at the foot of the building.
Tour this miniature version of the European continent featuring hundreds of replicas of the region's most well known landmarks. Including interactive displays of both manmade structures and natural phenomena, it's an ideal family experience that's fun and educational at the same time.
Explore the charm and history of the Grand Place, considered one of Europe's most beautiful squares. This well preserved 13th century marketplace features Gothic and Baroque architecture and often hosts concerts, as well as a colourful flower market during the warmer months, when it's also ideal to sit at a nearby café and people-watch.
Be captivated by The Flower Carpet, one of the city's most iconic installations occurring in the Grand Place every two years. Countless begonias of varying colours are elegantly arranged in a design that stretches some 20,000 square feet across the centre of the square.
Experience the fine arts at Le Monnaie, the city's opera house, or at the Royal Music Conservatory where you can enjoy live classical music. Discover Brussels' contemporary side at The Belgian Centre for Comic Strip Art, which features world famous locally created characters like Tintin and the Smurfs.
There's also a vibrant nightlife scene where you can experience what the locals call an 'apéro', which is going to a club or a bar for a small bite and a drink. Visit some of the more lively districts across the city including Place Chatelain, Place du Luxumburg and Place Flagey.
Dining and shopping
When heading out to enjoy a meal consider sampling some of the local cuisine, like Waterzooi, a truly Belgian stew traditionally made with fish and vegetables, or try the Flemish style mashed potato with stewed vegetables, called Stoemp.
Find an inspiring selection of cuisine in the picturesque Place de Grand Sablon. Along with traditional restaurants, you can also find chocolatiers, to satisfy your sweet tooth in this historic square.
Explore other popular places for dining across the city including Rue St Boniface and Place du Chatelain. Place Stephanie has smaller restaurants scattered throughout, especially along Rue Breckmans.
When it comes to shopping, the two streets known for high-end stores are Boulevard de Waterloo and Avenue Louise. While the former is one of the city's most popular streets and the latter one of the oldest, they both boast some of the world's most fashionable brand names.
See what you can find on one of the longest shopping streets in Brussels, Rue Neuve. Always bustling with activity, especially on weekends, you can find mid-range stores here and enjoy a long stroll down this pedestrianised avenue.
You can also find out more about the long history of lace making in Belgium, which is known for producing the world's most intricate lace patterns. See the work firsthand at the Museum of Costume and Lace, and if you are so inclined, take lessons in the traditional trade.
Beyond Brussels
Known as the 'smallest town on earth', you can wander through Durbuy's quaint cobbled streets, admire the ancient stone houses and visit one of the world's largest topiary parks. With an array of restaurants and cafés, it is especially popular for long summer walks.
The medieval city of Ghent is rich with history from the Castle of the Counts to the medieval district, which it overlooks. Explore the city on foot or by bicycle, or take a boat through its serene canals and waterways.
Tornai is another ancient city worth exploring and features famous historic buildings like The Belfry, the oldest in the country, and the Castle of Beloeil, which along with being centuries old, is home to an impressive collection of art and books. This city is also where the Museum of Tapestry and Textiles is based and features tapestry weaving, repair and research.
Explore the cobbled streets, charming canals and picturesque market squares of Bruges, a very popular tourist destination. You can sample handmade chocolates, visit the walking bring and stunning views in Minnewater, or wander through the historic Markt, where horse-drawn carriages and open-air restaurants will greet you.
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Edexcel GCSE Modern World HistoryPaperback History in Focus
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- Publisher: HODDER EDUCATION
- Format: Paperback | 408 pages
- Dimensions: 216mm x 276mm x 24mm | 1,124g
- Publication date: 11 September 2009
- Publication City/Country: London
- Edition: 3, Revised
- Edition statement: 3rd Revised edition
- Illustrations note: Full colour throughout
- Sales rank: 210,691
Product description
This title is being updated to support the 'strengthened' GCSE specification for first exam Summer 2015 Provide complete support for your GCSE Modern World History candidates with best-selling books and digital resources from an author you can really trust. An Edexcel specific edition of the best selling textbook for GCSE Modern World History. It comprehensively covers the Edexcel specification and provides a winning combination that will meet the needs of all students. - clear, engaging and provocative author text which brings the period to life and summarises complicated history clearly without being simplistic - Focus Tasks which steadily deepen students' understanding of the content (exactly targeting each topic of the Edexcel specification) while progressively building their history skills - original and relevant source material - written and visual - all of which is used for historical investigation not just for illustration - state-of-the-art ICT support in the form of a Dynamic Learning network CD-ROM from an author who leads the field in developing the use of ICT to help refine students historical thinking - authoritative interpretation of the Edexcel specification by experienced trainers - supported by comprehensive Teacher's Resource Book available in print and on CD, and high-quality, full colour, authoritative revision materials In its first and second editions this book has provided students with what they need to achieve top grades; and provided teachers with what they need to teach a rewarding and worthwhile course. A winning combination - don't settle for less.
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Ben Walsh and Christopher Culpin are both experienced GCSE history teachers and best-selling authors in Modern World History for GCSE. Ben Walsh is a celebrated expert in the use of digital technology in history teaching. As well as writing best selling books for GCSE Modern World History he has been the key developer of the highly praised Learning Curve online exhibitions for the National Archives (formerly the Public Record Office) and he has blazed a trail in the use of digital video archives in the teaching of GCSE history.
Table of contents
Unit 1 Peace and War: International Relations, 1900-1991 1: Why did war break out? International rivalry, 1900-14 2: The peace settlement, 1918-28 3: Why did war break out in 1939? International relations, 1929-39 4: How did the Cold War develop? 1943-56 5: Three Cold War crises, 1957-69 6: Why did the Cold War end? 1970-91 Exam focus Unit 2: Modern World Depth Studies 7: Germany, 1918-39 Exam focus 8: Russia, 1917-39 Exam focus 9: The USA, 1919-41 Exam focus Unit 3: Modern World Source Enquiry 10: War and the transformation of British society, c.1903-28 11: War and the transformation of British society, c.1931-51 12: A divided union? The USA, 1945-70 Exam focus Unit 4: Representations of History Controlled Assessment


text:
The invention relates to ultrasonic contrast agents composed of microparticles which contain a gas and polyamino-dicarboxylic acid-co-imide derivatives, to processes for their preparation and to their use as diagnostic and therapeutic agents.
1. A process for the preparation of an ultrasonic contrast agent composed of microparticles which contain a gas and a polyamino-dicarboxylic acid-co-imide derivative of the formula I ##STR4## in which n is 1 or 2
x is 1 to 500
y is 1 to 500, where
x+y is 2 to 1000, and
R is O--R1 or NH--R2, in which R2 is H, (CH2)m--OR1, (CH2)m--O--C(O)--R1 or (CH2)m --O--C(O)--OR1, and
m is 2 to 6, and
R1 is H, aryl, aralkyl, arylalkenyl, alkyl or C3 -C8 -cycloalkyl or a biologically inactive steroid alcohol or an amino acid, where aryl is unsubstituted or is substituted by C1 -C4 -alkyl, C2 -C4 -alkyl, C2 -C4 -alkenyl, C1 -C4 -alkylcarbonyloxy, C1 -C4 -alkoxy-carbonyl, C1 -C4 -alkoxy or hydroxyl,
where the alkyl radicals specified for R1 have 1-22 carbon atoms and the alkenyl radicals have 2-22 carbon atoms, which are not interrupted or are interrupted by a carbonyloxy or oxycarbonyl group, where the repeating units placed in square brackets are distributed randomly and/or in blocks in the polymer, and where both the repeating units labeled with x and those labeled with y are identical or different and where the amino acids are α- and/or β-linked, which process comprises:
(a) a solution of one or more polyamino-dicarboxylic acid-co-imide derivatives of the formula I or a solution of this or these derivatives which additionally contains one or more other polymers and/or physiologically acceptable auxiliaries being spray-dried, or
(b) one or more polyamino-dicarboxylic acid-co-imide derivatives of the formula I being dissolved in a solvent or solvent mixture with high melting point, or these derivatives being mixed with one or more other polymers and/or physiologically acceptable auxiliaries and dissolved in a solvent mixture with high melting point and then added dropwise to a condensed cold gas and subsequently the solvent being removed, or
(c) one or more polyamino-dicarboxylic acid-co-imide derivatives of the formula I being dissolved in a solvent or solvent mixture and subsequently, where appropriate after addition of another solvent and/or of one or more other polymers, being precipitated or dispersed in water, and the resulting suspension being freed of solvents.
This is a division of application Ser. No. 07/690,761, filed Apr. 24, 1991, U.S. Pat. No. 5,137,928.
The invention relates to ultrasonic contrast agents composed of microparticles which contain a gas and polyamino-dicarboxylic acid-co-imide derivatives, processes for their preparation and their use as diagnostic and therapeutic agents.
Ultrasonic diagnosis has become very widely used in medicine because it is complication-free and straightforward to perform. Ultrasonic waves are reflected at interfaces of different types of tissue. The echo signals produced thereby are electronically amplified and displayed.
Visualization of blood vessels and internal organs by ultrasound does not in general allow visualization of the blood flow present therein. Liquids, especially blood, provide ultrasonic contrast only when there are density differences with respect to the surroundings. Used as contrast agents in medical ultrasonic diagnosis are, for example, substances which contain gases or produce gases, because the difference in impedance between gas and surrounding blood is considerably greater than that between liquids or solids and blood (Levine R. A., J Am Coll Cardiol 3: 28, 1989; Machi I. J. CU 11: 3, 1983).
Several methods for preparing and stabilizing gas bubbles are disclosed in the literature. U.S. Pat. No. 4,276,885 describes the preparation of small gas bubbles of defined size which are enclosed by a gelatin casing which prevents coalescence of the gas bubbles. The prepared small gas bubbles can be stored only in the frozen state, and the small gas bubbles must be returned to body temperature for use.
EP-A2 0,123,235 and 0,122,624 describe ultrasonic contrast agents which contain gases and are composed of mixtures of surface-active substances with a solid in a liquid vehicle. The ultrasonic contrast agents are prepared by an elaborate milling process with an air-jet mill. The particles prepared in this way have only a short duration of use because they rapidly lose the entrapped gases.
EP-A2 0,224,934 describes ultrasonic contrast agents in the form of gas-filled gelatin or albumin hollow bodies. However, the disadvantage is the use of exogenous or denatured endogenous proteins because of the allergenic risk associated therewith.
EP-A1 0,327,490 describes microparticles which are composed of amyloses or synthetic, biodegradable polymers and of a gas and/or a liquid with a boiling point below 60� C. The disadvantages of these polymers are their sticky consistency in water or blood, their poor biodegradability, their toxicity or the production of toxic degradation products.
It has already been proposed (German Patent Application P 40 02 736.8) to employ polyamino-dicarboxylic acid-co-imide derivatives as biodegradable depot formulations of pharmaceuticals with controlled release of active substance.
The object of the present invention was to develop ultrasonic contrast agents based on microparticles, which provide a distinct contrast from the surrounding tissue, which are so small and stable that they reach, without considerable loss of gas and essentially quantitatively, the left half of the heart after intravenous administration, are well tolerated without an allergenic potential, do not form aggregates in water or blood, and can be prepared rapidly and straightforwardly.
Microparticles which are, surprisingly, outstandingly suitable as ultrasonic contrast agents have been prepared from polyamino-dicarboxylic acid-co-imide derivatives (polydicarboxylic acid-co-AHADA derivatives). In particular, the amenability of the prepared microparticles to be suspended in water is outstanding owing to the incorporation of unopened imide rings (AHADA rings). The microparticles do not have a sticky, greasy consistency in water-containing liquids and form scarcely any agglomerates. The polymers form a pharmacologically inert matrix in which the gas is entrapped. In vivo, these polymers are metabolized to non-toxic, non-allergenic and non-immunogenic compounds and are excreted. It was possible to show in animal experiments that the microparticles essentially pass through the lungs without significant loss of gas and result in an ultrasonic contrast of equal intensity in both halves of the heart. The echocardiograms recorded therewith show no wall-movement disturbances whatever during and up to 60 min after administration of the contrast agent. Furthermore, it was not possible to find any changes whatever in a six-channel ECG or in the contractility determined using a tip manometer.
The ultrasonic contrast agents according to the invention bring about an improved increase in echogenicity in the myocardium and permit improved visualization of the endocardium. It is furthermore possible, for example, to assess the following parameters better: ventricle size, wall-movement disturbances, stroke volume, ejection fraction or intracavitary masses, for example thrombi or tumors. Furthermore, the ultrasonic contrast agents according to the invention make it possible to evaluate flow patterns in cases of valvular insufficiency of the left and of the right half of the heart, intracardiac shunts, and improved visualization of the large vessels in cases of congenital malformation. A massive enhancement of the Doppler signal has also been observed.
The invention thus relates to ultrasonic contrast agents composed of microparticles which contain a gas and a polyamino-dicarboxylic acid-co-imide derivative of the formula I. ##STR1## in which n is 1 or 2
x is 1 to 500
y is 1 to 500, where
x+y is 2 to 1000, and
R is O--R1 or NH--R2, in which
R2 is H, (CH2)m --OR1, (CH2)m --O--C(O)--R1 or (CH2)m --O--C(O)--OR1, and
m is 2 to 6, and
R1 is H, aryl, aralkyl, arylalkenyl, alkyl or C3 -C8 -cycloalkyl or a biologically inactive steroid alcohol or an amino acid, where aryl is unsubstituted or is substituted by C1 -C4 -alkyl, C2 -C4 -alkenyl, C1 -C4 -alkylcarbonyloxy, C1 -C4 -alkoxycarbonyl, C1 -C4 -alkoxy or hydroxyl,
where the alkyl radicals specified for R1 have 1-22 carbon atoms and the alkenyl radicals have 2-22 carbon atoms, which are not interrupted or are interrupted by a carbonyloxy or oxycarbonyl group, where the repeating units placed in square brackets are distributed randomly and/or in blocks in the polymer, and where both the repeating units labeled with x and those labeled with y are identical or different and where the amino acids are α- and/or β-linked.
By aryl are meant aromatic hydrocarbons such as phenyl and naphthyl, especially phenyl. In the substituted aryl radicals indicated, 1 to all replaceable hydrogen atoms are replaced by identical or different substituents. The aryl radicals are preferably mono- or disubstituted. The said alkyl and alkenyl radicals can be both straightchain and branched. The biologically inactive steroid alcohols are preferably linked via their OH group. A preferred steroid alcohol is cholesterol. In the case of the amino acids specified for R1, they are preferably naturally occurring amino acids such as Tyr, Ala, Ser or Cys, particularly preferably Tyr and Ala. They can be linked both via their NH2 and via their COOH group.
The invention also relates to processes for the preparation of gas-containing microparticles which are composed of the abovementioned polymers or contain these, and to their use, also mixed with other, biocompatible and/or biodegradable polymers or physiologically acceptable auxiliaries, for diagnostic or therapeutic procedures.
The invention further relates to diagnostic or therapeutic agents composed of at least one ultrasonic contrast agent as claimed in one or more of claims 1 to 4 or of at least one ultrasonic contrast agent prepared by process 5.
The invention additionally relates to processes for the preparation of diagnostic or therapeutic agents, which comprise converting the abovementioned ultrasonic contrast agents with a physiological vehicle and, where appropriate, further additives and/or auxiliaries into a suitable administration form.
The invention is described in detail hereinafter.
Aspartic acid and/or glutamic acid are employed as amino dicarboxylic acids which react in a polycondensation reaction to give the corresponding polyimides (polyanhydro-amino-dicarboxylic acids, formula II). Partial reaction with one or more compounds of the formulae III and/or IV and/or NH3
H2 N--(CH2)m --OH (IV),
in which m and R1 are defined as above for formula I, results in an α, β-poly-D,L-amino acid ester-co-imide of the formula VIII ##STR2##
It is essential that in this reaction the polyanhydroamino-dicarboxylic acid (II) is only partially converted into the open-chain derivatives. The proportion of unopened anhydro-amino-dicarboxylic acid units is 0.1 to 99.9%, preferably 10 to 90% (the percentages relate to the total number of repeating units in the total polymer). Depending on the side on which the imide ring is opened in the reaction described above, α- or β-linked amino acids are obtained. Compounds of the formulae III and IV which are preferably employed are: 2-aminoethanol, 3-aminopropanol, 2-aminopropanol, alcohols with 1-18 carbon atoms, especially methanol, ethanol, isoamyl alcohol and isopropyl alcohol.
A process for the preparation of α,β-poly-(2-hydroxyethyl)-DL-aspartimide (PHEA) (formula I; Y=0; R=NH--CH2 --CH2 --OH) is described by P. Neri, G. Antoni, F. Benvenuti, F. Cocola, G. Gazzei, in J. Med. Chem. Vol. 16, 893 (1973). A general procedure for the preparation of PHEA is to be found in P. Neri, G. Antoni, Macromol. Synth. Vol. 8, 25. Express reference is made to this citation at this point. The reaction takes place in high yield to give a product of high purity. It is possible to prepare in the same way, by less than stoichiometric use of NH3 and/or compounds of the formulae III and/or IV, the analogous poly-aspartic acid derivative-co-succinimide compounds of the formula VIII (n=1).
A different, more elaborate process as is described in U.S. Pat. No. 4,356,166 must be used to prepare pure poly(hydroxyalkyl)-L-glutamine. This entails initially the γ-COOH group of the L-glutamic acid being protected by esterification with benzyl alcohol. This γ-benzyl glutamate is subsequently reacted with phosgene to give an N-carboxylic anhydride which then polymerizes after addition of triethylamine in an inert solvent to result in poly-γ-(benzyl)-L-glutamate. The protective group is eliminated either by adding an HCl/HBr mixture to give the free poly-α-L-glutamic acid or else in the presence of hydroxyalkylamines to give the analogous poly-α-(hydroxyalkyl)-L-glutamines. A general procedure for the preparation of poly-α-(hydroxypropyl)-L-glutamine is to be found in U.S. Pat. No. 4,356,166, to which express reference is made at this point. It is also possible in the same way, by using NH3 and/or compounds of the formula III and/or IV, to prepare the analogous compounds of the formula VIII (n=2).
Compared with the elaborate preparation of pure polyglutamic acid and its derivatives, it is possible to incorporate glutamic acid in up to high proportions on simple condensation of aspartic acid using phosphoric acid to give polyanhydroaspartic acid-co-glutamic acid.
The polyamino-amide-co-imides of the formula VIII (R'=HN--(CH2)m --OH) can now, if necessary, be reacted in the following reaction step with one or more different biologically inactive compounds of the formula V and/or VI and/or VII ##STR3## to give further polyamino-dicarboxylic acid-co-AHADA derivatives. In this case, X is a leaving group which allows mild esterification of the polymer alcohol group. Chlorine, bromine, iodine, imidazolides, anhydrides or hydroxyl, especially chlorine, are preferred.
The reaction with the compounds of the formula V, VI or VII type can be carried out both with a single compound of this type and with any desired combinations of these compounds, or else with compounds which have different radicals R1, for example differing in the nature of their branching, in particular in their chain length. The last-mentioned alkylation or acylation on the polymer is carried out by known processes of organic chemistry. It takes place selectively on the hydroxyl group (formula VIII, R'=HN--(CH2)m --OH) to give ethers, esters, or carbonates without attacking other groups on the initial polymer. Particularly suitable is the Einhorn variant of the Schotten-Baumann acylation in the presence of pyridine. In this case, very high levels of derivitization (greater than 70%) are achieved under mild conditions.
The molecular weight of the polymers is 200 to 100,000, preferably 3,000 to 70,000.
Compounds of the formula V type can be bought or, if not, synthesized in a straightforward manner by processes known from the literature.
The chloroformic esters (formula VII) are obtained by reacting phosgene with the appropriate biologically inactive, physiologically acceptable, aromatic, araliphatic, aliphatic or cycloaliphatic, especially unbranched alcohols. The alcohols which are particularly preferably employed are those which have an even number of carbon atoms. The chloroformylated steroids are also obtained in this way. Thus, in principle, all biologically inactive steroids having reactive hydroxyl groups can be obtained. Examples which may be mentioned here are: cholesterol, cholestanol, coprostanol, ergosterol, sitosterol or stigmasterol.
The acid chlorides (formula VI) which can likewise be employed are obtained, for example, from the corresponding carboxylic acids by reaction with phosphorus trichloride, phosphorus pentachloride, oxalyl chloride or thionyl chloride.
Compounds of the formula V, VI or VII type in which an alkyl chain is interrupted by an oxycarbonyl or carbonyloxy group are prepared, for example, by reaction of cyclic dicarboxylic acid anhydrides with alcohols. The dicarboxylic monoesters obtained in this way are then reacted in analogy to the carboxylic acids described above, for example with oxalyl chloride, to give the corresponding acid chlorides.
An advantageous process for the preparation of the ultrasonic contrast agents comprises dissolving one or more of the polyamino-dicarboxylic acid-co-imide derivatives of the formula I in a solvent or solvent mixture with high melting point, or mixing these derivatives with one or more other polymers and/or physiologically acceptable auxiliaries, and dissolving in a solvent or solvent mixture with high melting point, and adding dropwise to a condensed cold gas, for example liquid nitrogen. This results, owing to the Leidenfrost phenomenon, in absolutely round particles. Examples of solvents which can be employed are alcohols, dimethylformamide, dimethyl sulfoxide, tetrahydrofuran, methylene chloride, dioxane, acetonitrile or mixtures with alcohols. The high-melting and water-miscible solvent is dissolved out, for example by transferring the microparticles into water, and the polymer is precipitated thereby, with retention of the spherical shape of the microparticles.
If the organic solvent which is used not only has a high melting point but also has a low boiling point, this dropwise addition process can be further simplified by the possibility of removing the solvent, for example tert-butanol, directly and under mild conditions by freeze-drying.
Another process for the preparation of the ultrasonic contrast agents comprises one or more of the polyamino-dicarboxylic acid-co-imide derivatives of the formula I being dissolved in a solvent or solvent mixture and, where appropriate after addition of another solvent and/or of one or more further polymers, being precipitated or dispersed in water. Examples of other polymers which are suitable are polyvinyl alcohol (�Mowiol 28-99) or polyoxyethylene-polyoxypropylene (�Pluronic F 127). Ethers, for example, can be used as further solvents. Microparticles with a diameter of 0.5 to 15 μm are obtained by vigorous stirring, for example with a mixer (25,000 rpm). The solvents are subsequently removed, for example by lyophilization.
A particularly advantageous process comprises obtaining the microparticles by spray-drying. For this, one or more polyamino-dicarboxylic acid-co-imide derivatives of the formula I are dissolved, or these derivatives are mixed with one or more other polymers and/or physiologically acceptable auxiliaries and dissolved. Examples of suitable solvents or solvent mixtures are alcohol, dimethylformamide, dimethyl sulfoxide, tetrahydrofuran, methylene chloride, dioxane or acetonitrile. The solution is then sprayed to give microparticles in a spray drier.
The polymers of the formula I can be used alone or else as mixture of various polymers of the formula I in the described process. These polymers can also be employed in mixtures with other biodegradable and/or biocompatible polymers (for example �Pluronic F68, PHEA, dextrans, polyethylene glycols, hydroxyethyl starch and other degradable or excretable polysaccharides) or physiologically acceptable auxiliaries (for example polymer plasticizers).
The microparticles contain gas, for example air, nitrogen, noble gases such as helium, neon, argon or krypton, hydrogen, carbon dioxide, oxygen or mixtures thereof. The microparticles are charged with a gas by, for example, the microparticles being stored in an appropriate gas atmosphere after the lyophilization or, in the case of spray-drying, are obtained directly on preparation in an appropriate gas atmosphere. The ultrasonic contrast agents according to the invention are converted before administration into a suitable diagnostic or therapeutic administration form by addition of one or more physiologically acceptable vehicles and, where appropriate, further additives and/or auxiliaries. The ultrasonic contrast agents are, for example, suspended before administration by addition of water and mixing.
Physiological isotonicity of the particle suspension can be set up by addition of substances with osmotic activity, for example sodium chloride, galactose, glucose or fructose.
The described process for the preparation of the ultrasonic contrast agents according to the invention can result in particle sizes in which 90% of the particles are between 0.1 μm and 15 μm. Using the spray-drying process it is possible to obtain particle size distributions in which 90% of the particles are smaller than 3 μm. Larger particles are removed by screening out, for example with a 15 μm screen fabric and/or 3 μm screen fabric. When these microparticles are used as ultrasonic contrast agents for the diagnosis of cardiovascular disorders, particle sizes of 0.1 μm to 7 μm have proven suitable, and particle sizes of 0.1 μm to 3 μm are preferably employed. The ultrasonic contrast agents are injected, for example, into the blood circulation. Per injection, 0.1 mg to 1000 mg of the microparticles, preferably 1 mg to 100 mg, are employed.
The ultrasonic contrast agents described above can be used for both diagnostic and therapeutic procedures. The use of the ultrasonic contrast agents according to the invention is not confined just to the visualization of the blood flow in the right-ventricular part of the blood circulation after venous administration. The ultrasonic contrast agents can be used with exceptional success for investigating the left side of the heart and the myocardium. Furthermore, it is also possible to visualize other organs with a blood supply, such as the liver, spleen, kidney or brain, using these contrast agents.
The ultrasonic contrast agents according to the invention are, however, also suitable for the visualization of cavities in humans, animals or plants, for example the urinary bladder, ureter, uterus or vagina.
The invention is described in detail in the examples which follow. Unless otherwise indicated, percentages relate to weight.
10 g (103 mmol) of polyanhydroaspartic acid are dissolved in about 40 ml of N,N-dimethylformamide (DMF), if necessary warming gently. To this solution are added dropwise 1.83 g (30 mmol) of freshly distilled 2-aminoethanol and stirred at room temperature overnight. The reaction mixture is precipitated in butanol and washed several times with dry acetone. The drying is carried out at elevated temperature in vacuo. The white, water-soluble product is obtained in approximately 100% yield and is examined by NMR spectroscopy for residues of DMF and butanol. The molar ratio of polyanhydroaspartic acid to aminoethanol employed corresponds approximately to the copolymer compostion.
Excess thionyl chloride and one drop of DMF are added to monobutyl succinate. The reaction takes place with evolution of gas. The mixture is left to stir with exclusion of moisture overnight and subsequently the excess thionyl chloride is removed by distillation under atmospheric pressure. The remaining crude product is fractionally distilled under 0.05 mbar, and the pure product is obtained at about 70� C. The characterization of the product by IR spectroscopy shows bands at 1800 cm-1 (acid chloride) and 1740 cm-1 (ester) of equal intensity.
6 g of polysuccinimide-co-α,β-(hydroxyethyl)-D,L-aspartamide (=16 mmol of hydroxyethyl groups), prepared as described in Example 1, are dissolved in 100 ml of dry N,N-dimethylformamide (DMF). Addition of 4 g (50 mmol) of pyridine is followed by cooling to 0� C. and addition, while stirring, of 4.8 g (25 mmol) of n-butyl 4-chloro-4-oxobutyrate (see Example 2) over the course of 15 minutes. The mixture is stirred overnight and precipitated in 0.5 1 of ether. The precipitate is filtered off with suction and washed with ether, acetone, water, acetone and ether. The result is about 8 g of a white polymer with an approximately 100% degree of substitution (can be checked by NMR spectroscopy). The resulting polymer is soluble, for example, in acetonitrile with a trace of dimethyl sulfoxide (DMSO), in DMSO or DMF.
6 g of a polysuccinimide-co-α,β-(hydroxyethyl)-D,L-aspartamide (50:50) (=24 mmol of hydroxyethyl groups), which was prepared in analogy to Example 1 from polyanhydroaspartic acid (MW=14000) and 2-aminoethanol (molar ratio 2:1), are dissolved in 100 ml of dry DMF, and 8 g (100 mmol) of dry pyridine are added and cooled to 0� C. 9.6 g of distilled decanoyl chloride are slowly added dropwise, and further operations are in analogy to Example 3. About 8 g of a white, completely substituted polymer (NMR check) which is soluble, for example, in dichloromethane and THF with, in each case, a trace of DMSO or in methanol/dichloromethane mixtures are obtained.
In analogy to Example 1, various polysuccinimide-co-α,β-(hydroxyethyl)-D,L-aspartamides of, inter alia, the compositions 70:30, 50:50 and 30:70 were prepared from polyanhydroaspartic acids of various molecular weights (MW=7000; about 13000; 30000) and reacted with decanoyl chloride as described in Example 4 to give the corresponding polysuccinimide-co-α,β-(nonylcarbonyloxyethyl)-D,L-aspartamides.
a) polysuccinimide-co-α,β-(nonylcarbonyloxyethyl)-D,L-aspartamide(70:30) from polyanhydroaspartic acid (MW=7000); characterized by NMR
b) polysuccinimide-co-α,β-(nonylcarbonyloxyethyl)-D,L-aspartamide(70:30) from polyanhydroaspartic acid (MW=14000); characterized by NMR
c) polysuccinimide-co-α,β-(nonylcarbonyloxyethyl)-D,L-aspartamide(70:30) from polyanhydroaspartic acid (MW=30000); characterized by NMR
d) polysuccinimide-co-α,β-(nonylcarbonyloxyethyl)-D,L-aspartamide(30:70) from polyanhydroaspartic acid (MW=12000); characterized by NMR.
6 g of polysuccinimide-co-α,β-(hydroxyethyl)-D,L-aspartamide (70:30) (=16 mmol of hydroxyethyl groups), prepared as described in Example 1 from polyanhydroaspartic acid, (MW=37000) and aminoethanol, are reacted in analogy to Example 3 with 4.8 g (25 mmol) of octyl chloroformate and worked up correspondingly. About 8 g of a white, completely substituted polymer which is soluble in THF or methanol/dichloromethane mixtures are obtained.
6 g of polysuccinimide-co-α,β-(hydroxyethyl)-D,L-aspartamide (60:40) (=20 mmol of hydroxyethyl groups), which was prepared in analogy to Example 1 from polyanhydroaspartic acid and 2-aminoethanol (molar ratio 6:4), are reacted in analogy to Example 3 with 2.3 g of decanoyl chloride (=12 mmol). Because reaction was incomplete (relatively low excess of acid chloride), only half the free OH groups are esterified. The result is about 7 g of a white polymer. Microparticles of this substance show a firm consistency in water and are easily suspendible.
6 g of polysuccinimide-co-α,β-(hydroxyethyl)-D,L-aspartamide (10:90) (=40 mmol of hydroxyethyl groups), prepared in analogy to Example 1 with a 1:9 molar ratio of polyanhydroaspartic acid to 2-aminoethanol, are reacted with 20 g of distilled oleyl chloride in analogy to Example 3. The heterogeneous reaction mixture becomes homogeneous on addition of dichloromethane. It is precipitated twice in methanol which is cooled to -20� C. The yellowish-colored polymer is thermoplastic.
a) Preparation of microparticles
40 mg of polysuccinimide-co-α,β-(nonylcarbonyloxyethyl)-D,L-aspartamide (50:50) from Example 4 are dissolved in 1 ml of methylene chloride/methanol (proportion 50/1 by volume). The solution is introduced while stirring (800 rpm) into a beaker containing 60 ml of 0.1% by weight of aqueous polyvinyl alcohol solution (�Mowiol 28-99) which is saturated with 0.3 ml of methylene chloride/methanol (50/1). At the same time, the solution is finely dispersed with a mixer (25,000 rpm).
After 5 minutes, the contents are poured into a beaker containing 200 ml of water and stirred for 30 minutes (200 rpm). The supernatant water is decanted off and the microparticles are lyophilized (diameter after lyophilization: 0.5 to 15 μm).
80 mg of polysuccinimide-co-α,β-(octylcarbonyloxyethyl)-D,L-aspartamide (70:30) from Example (6 are dissolved at 50� C. in 1 ml of dimethyl sulfoxide, and 20 mg of hydroxypropylcellulose (�Klucel M.) are added. The solution of the two polymers is added dropwise, using a needle (disposable syringe, external diameter of needle 0.6 mm), to previously introduced liquid nitrogen (100 ml).
The resulting microparticles are transferred into 200 ml of water and extracted from remaining solvent for 2 hours. Excess water is decanted off, and the microparticles are lyophilized (diameter after lyophilization: 1-2 μm).
4 g each of polysuccinimide-co-α,β-(octyloxycarbonyloxyethyl)-D,L-aspartamide (A) (Example 6) and polysuccinimide-co-α,β-(nonylcarbonyloxyethyl)-D,L-aspartamide (B) (Example 5 d) are made into 2% solutions in the solvents indicated in Table 1. The polymers are subsequently sprayed to give microparticles in a spray drier (Buchi 190 mini spray drier supplied by Buchi, West Germany).
TABLE 1______________________________________ Particle sizeSub- 10% smaller 50% smaller 90% smallerstance Solvent than than than______________________________________A THF 1.6 μm 3.6 μm 6.7 μmB CH2 Cl2 2.4 μm 3.6 μm 6.7 μmB CH2 Cl2 / 1.3 μm 1.9 μm 3.0 μm methanol 3.6:1 (vol.)B CH2 Cl2 / 1.2 μm 1.8 μm 2.6 μm methanol 2:3 (vol.)B THF/ 1.3 μm 1.9 μm 2.7 μm methanol 3.6:1 (vol.)______________________________________
The size distribution of the microparticles was determined in a Cilas 715 granulometer.
In each case, 30 mg portions of the microparticles prepared above are dispersed in 1.5 ml of suspension aid. The suspension aids are composed of 150 mg of dextran 40 (supplied by Roth, West Germany), 7.5 mg of polysorbate and 13.5 mg of NaCl in 1.5 ml of distilled water. The suspensions are filtered using screen fabrics (15 μm and 3 μm mesh width) and subsequently lyophilized. Before administration, the microparticles are suspended in water.
30 mg of microparticles (prepared as in Example 11, substance B, CH2 Cl2 /methanol 2:3 (vol.)) are resuspended in 1.5 ml of distilled water using a glass rod. This suspension is injected into a peripheral vein using an injection syringe. An ultrasound emitter of an ultrasonic apparatus (Toshiba, FSH 160a, Japan) is held on the thorax of the experimental animal so that a typical cross-section through the right and left heart is obtained. As soon as the ultrasonic contrast agent reaches the right half of the heart it is possible to see on the monitor of the ultrasonic apparatus how the blood labeled by the contrast agent reaches the right atrium, then the right ventricle and subsequently leaves the heart again via the pulmonary artery. After passage through the lungs, the left half of the heart can be seen owing to the contrast agent. The ultrasonic contrast is of equal intensity before and after passage through the lungs so that it can be assumed that there is essentially complete retention of the air in the polymers and essentially loss-free transport of the microparticles to the left half of the heart.
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Treasury has announced that it has taken action to increase pressure on the Syrian regime and those providing support that could aid its military efforts. The Treasury Department designated United Arab Emirates-based Pangates International Corporation Ltd. (Pangates) pursuant to Executive Order (E.O.) 13582 for providing material support for, and goods and services to, the Government of Syria, including SYTROL, a Syrian state oil company sanctioned by the United States. The Treasury Department also designated Syria-based front companies Expert Partners and Megatrade pursuant to E.O. 13382 for acting for or on behalf of the U.S.-sanctioned entity Scientific Studies and Research Center (SSRC), Syria's government agency responsible for developing and producing non-conventional weapons and ballistic missiles. Both SYTROL and SSRC have been sanctioned by the European Union.
U.S. persons are generally prohibited from engaging in any transactions with the persons identified in Treasury's announcement, and any assets of those persons subject to U.S. jurisdiction are frozen. From the onset of unrest in Syria to date, the United States has imposed sanctions on nearly 200 individuals and entities, including the Government of Syria, its Central Bank, and affiliated oil companies.
EXPERT PARTNERS (a.k.a. EXPERTS PARTNERS), Rukn Addin, Saladin Street, Building 5, PO Box 7006, Damascus, Syria [NPWMD].
MEGATRADE, Aleppo Street, PO Box 5966, Damascus, Syria [NPWMD].
PANGATES INTERNATIONAL CORPORATION LIMITED, P.O. Box 8177, Sharjah Airport International Free Zone, Sharjah, United Arab Emirates; Office Y-47, Sharjah Airport International Free Zone, Sharjah, United Arab Emirates; P.O. Box 5797, Damascus, Syria; Website www.pangates-me.com; Email Address firstname.lastname@example.com; alt. Email Address email@example.com [SYRIA].


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By Mike Poff Big Island
Critics, pundits, parents, Christians and everything in-between across the nations' media, breakfast tables, and internet enabled tablets are fumbling and stumbling all around the sad revelations regarding the Duggar family, their TV show, their influence, their faith, and their failures. All old Duggar foes sense blood in the water and swarm for the kill. Old allies rally and circle the wagons and the ruckus just rolls on and on in a modern moral bi-polar free for all.
If you live in District 5, 6 or 7 you need to get out and cast a ballot in the Republican Primary this Tuesday, June 9.
In each of those districts there are contested elections for the Republican nomination, which it appears will decide who the next supervisor for those districts will be. As of this time, no Democrat or independent has expressed an interest in running against the nominees chosen in the Republican Primary.
Last year, when Darren Wilson, a white Ferguson, Missouri, police officer, fatally shot Michael Brown, an unarmed black man, the denizens of America's liberal political swamp all shrieked "racist." They implied that this happened because the officer is white, there were hardly any black officers on the police force, the police chief was white and five of the city's six city councilmen are white. The city is 25 percent black.
Not long ago I asked a rhetorical question here, wondering if anyone could provide the details of even one single program of humane reform brought to this country by conservatives.
No one has offered any serious suggestions, and we know why. In the post World-War II era, reaction to FDR's New Deal produced a conservative backlash.
By Kitty Jennings
In response to Letter to the Editor in News & Advance on May 27, 2015, by Gary Hostutler: Once again, the School Board is pointing the finger at the Bedford County Supervisors for inaction on the new Middle School Project. There needs to be some clarification on this issue.
Human life is a precious gift. As a father who has recently become a grandfather, I know that the gift of life is one that must be fiercely protected. Since the Supreme Court's decision in Roe v. Wade more than 40 years ago, medical knowledge regarding the development of unborn babies has advanced dramatically. Extensive medical research shows that unborn children begin to feel pain by 20 weeks after conception, and probably earlier.
This month has seen lots of graduating university seniors collecting their college degrees at schools across America. Soon, others will be collecting something from them — payments on their student loans. Almost all of these new graduates took on some level of student debt during the process of pursuing their undergraduate degree. I've read that the average student loan debt load upon graduation is close to $30,000. This is an average and that, of course, means that some incurred less student debt while some took on substantially more.
I've often remarked here that the basic constituency of the national Republican Party is "old white men." It's obviously not possible to build a future winning coalition on such a demographic.
I was right. I refer you to a very informative article on Politico.com, which, by the way, is an essential source if you're a political animal.
Copyright © 2015
The Bedford Bulletin is your source for local news, sports, events, and information in Bedford County and Bedford, VA and the surrounding area.


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If you missed my previous stress relief tips, please find the tips here.
One of the most simple tips that I don't like to do, but it REALLY does help when you are stressed, is to go to bed. When I mean go to bed, I mean go to bed early. If possible, drop everything you are doing, and just go to bed an hour early. I know that sounds crazy, more sleep can help reduce stress. If you suffer from lack of sleep and you are stressed, your immune system becomes more compromised. Sleep is so important.
It is hard for me to want to go to sleep because I have a million things on my mind and other things I want to do. Make a goal for yourself to try and go to bed an hour earlier than you usually do. Try it and you will see, it really does help!


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County Scene sport, August 31
Posted: August 31, 2012|
Chris Harris's hopes of securing an automatic berth in the 2013 World Championship Grand Prix series are all but over after a disappointing night in Cardiff last Saturday, writes Nigel Walrond.
The 29-year-old Cornishman could manage only six points in the British Grand Prix at the Millennium Stadium in front of thousands of his adoring fans.
It leaves him still 24 points adrift of a place in the top eight in the overall standings – which would guarantee him his position in the World Championship next year - with only three rounds remaining.
Harris, from Probus, will need something of a miracle to turn that situation around, and will surely have to rely once more on a wild card from the Grand Prix organisers if he is to feature on the world stage again in 2013.
Harris was simply not quick enough at Cardiff in front of a 38,000-strong crowd, and his dreams of reaching the semi-finals were virtually at an end after his first three rides.
A third position and a last place in his opening two outings, when he failed to take advantage of having the inside gates that proved very beneficial in the early stages of the meeting, were followed by another third spot in heat 10.
It meant he had to win his remaining two rides to stand any chance of reaching the semi-finals, but despite showing signs of an improvement, two second-places left him one point short of the seven-point tally he needed to figure in the closing races of another fantastic event in the Welsh capital.
The meeting was won by Australian Chris Holder, with his Poole team-mate Krzysztof Kasprzak second, and Swedish duo Antonio Lindback and Freddie Lindgren third and fourth respectively.
Another Cornishman, Ben Barker, was one of the two reserves for the meeting for the third year running, but as in 2010 and 2011, his services were not needed, with none of the 16 riders pulling out of their scheduled rides.
The date for the 2013 British Grand Prix in Cardiff has been announced as Saturday, June 1.
British GP: 1 Holder 23 points, 2 Kasprzak 13, 3 Lindback 12, 4 Lindgren 12. Other points scorers: Sayfutdinov 12, N Pedersen 11, Gollob 10, Andersen 10, Vaculik 7, Hancock 7, Nicholls 7, Jonsson 6, Harris 6, Crump 6, B Pedersen 2, Ljung 0.
Overall standings: Hancock 118, Holder 117, N Pedersen 112, Crump 103, Sayfutdinov 96, Gollob 93, Lindgren 89, Jonsson 76, Lindback 74, Andersen 53, Harris 52, Vaculik 49, Hampel 46, Ljung 44, B Pedersen 43.
Cornwall, winners of the South West Federation of Croquet Clubs' South West Division Intermediate League, beat Lym Valley, winners of the South East division, 7-0 in the Intermediate League semi-final at Porthpean.
The final will be between Cornwall and the winners of The North v Central Divisions, probably on September 16, at Nailsea.
Play commenced with one double and two singles. Honey v Cousins, hoops came slowly in a close fought game, Honey prevailing in the end 20-15 on time. The other single Dexter v Rees again progressed slowly, Dexter winning 19-8 on time.
The double Cutting & Jennings v Hoare & Wilcox was hard fought, Cutting & Jennings winning 15-12 on time. By lunch time Cornwall were 3-0 up.
The afternoon play was four singles. Cutting v Rees game started slowly, but Cutting got his eye in & romped away to win 26-3 with plenty of time to spare.
Jennings v Cousins started in a similar way but Jennings form turned good & won 26-6 again with time to spare.
The other two singles were not going quite so well. Honey v Wilcox was very close run, Honey eventually coming out the winner 17-16 on time.
The last single was Dexter v Hoare again hoops did not come easily in the end Dexter managed to get away to win 12-7 when time ran out.
Cornwall: Tony Jennings (handicap 16), Peter Cutting (12), Des Honey (11), Peter Dexter (16).
Lym Valley: Richard Cousins (14), Jack Hoare (16), Huw Rees (12), Ken Wilcox (18).
Rifle Shooting
A good entry of 40 shooters entered for this year's Cornwall Open. So bringing it forward three weeks from the Bank Holiday seems to be working.
The first shoot of the weekend was a 2 x 10 at 300yds. This is a warm up match and not part of the overall Grand Agg. Right on message 1 (start time) the rain duly arrived. A little irritating, but passed quickly.
However, as the second detail started, it was déjà vu for those unlucky enough to be caught on the 11am detail of this year's Donegall, at the Bisley imperial meeting in July. So Eagle Eyes out and carry on. Stuart Larter–Whicher ran out the winner with a 50.6, followed by George Gilpin 50.4 and Andrew Wilde 49.9.
Match 2 was fired on the 300yd metric target This smaller bull certainly seems to concentrate the mind as evidenced by the scores made by Robin Hallows 100.5, and Steve Maris counting out Andrew Wilde on 100.3.
After lunch, we moved back to 500yds for a 2 x 15, which was won by Andy Gent 75.11, with Mike Frost 75.6, and another 3rd place for Andrew Wilde on 74.9. The wind bracket about 1 ½ mins from the east.
Saturday concluded with a 2 x 10 at 600yds. Jonathan Haward came out on top with a 50.8 with Tony Jones counting out Mike Frost, both on 50.7. The wind remained from the east, down to a minute bracket, but after the downpour at the start of the day, it remained dry for the shoots.
Sunday morning had on its black face, however once we got down on the point, the rain kept off, and did so for the rest of the day, even enjoying some sunshine.A rare commodity this summer.
Match 8 Sunday morning consisted of 2 x 15 at 500 and 600yds. This was won by Dave Crispin with a splendid 150.23, Jon Cload 149.22 just edging Andrew Wilde 149.18 into yet another third place.
This match is a concurrent match for the Inter Counties team match, which was won by Surrey with a score of 391.77 ex. 400, with Devon in 2nd place. Again, light winds from the east kept the bracket to about 1 -1 1/2 mins.
The meeting concluded with the top 20 in the Agg plus the top 3 F class shooting a 1 x 15 @ 600yds for The Duke of Cornwall Trophy. This was won by Jonathan Haward 75.10, Jon Cload 74.14 (not his last I hasten to add) and Dave Crispin 74.10.
Dave Pickering emerged victorious in the F Class battle, winning both the Saturday Agg and Grand, with Ian Mowbray second and Paul Calvert in third.
Carlsberg South West Peninsula Football League chairman Mark Hayman completed his sponsored 15,000 foot parachute jump at Dunkerswell Airfield in East Devon in aid of the league's Benevolent Fund during the summer close season.
After rounding up the pre jump pledges a delighted Hayman revealed to the league's board at their bi-monthly meeting last Thursday that the total sum raised from his efforts is £4,500, meaning that the league's fund – used to help relieve financial hardship by any person connected to the South West Peninsula Football League – has had a significant shot in the arm.
Donations from member clubs, including many from Cornwall, was exceptional with one club raising £400 and six others giving three figured sums to the cause with the total amount from the 51 clubs in these harsh economic climate was approaching £2,500.
Support from league sponsors, local business' and Hayman's business connections and friends ensured that the sum raised well exceeded expectations.
Hayman said: "I would have been content with raising a thousand pounds but once the enthusiasm of those I contacted took over I knew we were going to reach a sizeable figure for a cause very close to my heart.
"I want to sincerely thank everyone who kindly made donations from Penzance all the way up to Dumfries in Scotland, the vast majority of the clubs were brilliant and I can't thank individuals enough in those clubs that went out of their way to raise this money on our behalf – they are a credit to their clubs"
The league is now in its sixth year and in that time nearly £10,000 has been paid out to those in times of need in the league with more than 50 claimants receiving a financial boost while being unable to play or officiate.
Hayman added: "When the fund pays out to a self employed player with young children it is very rewarding and this extra money raised means we can give a little bit more where required in these hard times.
"I have been pleasantly surprised how much some individuals paid in at clubs as there are tough times out there for them and money for their own means is hard enough to come by.
"The officers and board oversee a league that is enjoyable to be part of and that comes from good people, running good clubs and this important fund raiser has strengthened that point."
Although the jump took place over two months ago the league's fund is open to donations at any point in time and asked if he would go through with it again Hayman said: "Only if I could raise that same amount again as the experience was great but it would take a similar amount for the same worthy cause to do so."
The day's heavy rain relented and a warm calm evening greeted the huge field of more than 200 runners, who assembled in the grounds of the National Trust at Trelissick for the Trelissick 10K off road trail run – round eight of the Cornwall Multi Terrain Race Series, sponsored by Personal Best Running Store at Carlyon Bay, St Austell, writes Alan Rowling. The steep uphill and downhill sections of the first mile soon stretched the field, with five runners detaching themselves early on in the Men's race, led by James Waldie (Cornwall AC) and Tony Brewer (Mile High), with Ben Price (Cheltenham), Andrew Martin (Mile High) and Stuart Ansell (Oxford) in hot pursuit.
Waldie, a fell running specialist who recently won the season's fifth race of the Scottish Hill Running Championships beating a few Scottish internationals in the process, was content to run alongside Brewer until the two mile point, before finding himself moving clear of the Mile High man on one of the many uphill sections, as he relentlessly moved further and further ahead, eventually crossing the line almost three minutes ahead of Brewer, who had settled for second before the half way point.
The winner, who is currently studying at Edinburgh University, did admit afterwards: "The key to success on this course, which is a serious challenge for all runners, is not to start too fast. This was my plan and it worked out well, as I felt I was still running strongly at the end."
Price, who knows the area well having organised the first few 10K off road races at Trelissick a few years ago, finished third, ahead of Martin, with Stuart Nicholas (St Austell Running Club) moving through, after a more sensible start than most, crossing the line in sixth position.
The Ladies' race was won by Jasmine Finney (Bude Rats), who led from the start and was delighted to win her second Multi Terrain Series race of the summer, having triumphed in her club's own race, the Bude Lifeboat Run in June.
Jasmine finished 40 seconds ahead of 18-year-old Zoe Barber (Westbury Harriers, Bristol), who was racing over 10K for the first time and coped extremely well with this very demanding course.
Youth certainly prevailed at Trelissick, with the top two youngsters leading a procession of no less than 16 lady Veteran runners, with Revis Crowle (East Cornwall Harriers) leading the more Senior runners home in third place.
In the team competition, St Austell Running Club were clear winners in the Men's race, comfortably ahead of Falmouth Road Runners (2nd) and Cornwall AC (3rd).
The Ladies' team competition was a much closer affair, with East Cornwall Harriers beating another club from the east of the county, Bude Rats, by just four points, with Falmouth Road Runners a distant third and just one point in front of St Austell Running Club.
Key for clubs: BR Bude Rats, CAC Cornwall AC, CHE Cheltenham, CR Carn Runners, ECH East Cornwall Harriers, FRR Falmouth Road Runners, G&G Grit & Grin, HR Hayle Runners, LRR Launceston Road Runners, MH Mile High, NRR Newquay Road Runners, OX Oxford, STA St Austell Running Club, TAV Tavistock AC, TRC Truro Running Club, U Unattached, WH Westbury Harriers Bristol.
Results: Men: 1 James Waldie CAC 39.36, 2 Tony Brewer MH 42.14, 3 Ben Price CHE 42.55, 4 Andrew Martin MH 43.16, 5 Stuart Nicholas STA 43.28, 6 Stuart Ansell OX 44.00.
Age Categories: Under 40: 1 James Waldie, 2 Tony Brewer, 3 Ben Price. 40-44: 1 Stuart Ansell, 2 Justin Day CAC 44.58, 3 Stephen Hands STA 45.55. 45-49: 1 Rich Savage HR 44.08, 2 Duncan Oakes STA 45.13, 3 Glynn Davis CR 45.38.
50-54: 1 Ian Crowle ECH, 46.36, 2 Martin Davis NRR 46.52, 3 Gary Pascoe TRC 47.56. 55-59: 1 Malcolm Roberts STA 48.22, 2 Chris Moncaster NRR 50.37, 3 Peter Allen NRR 52.29.
60-64: 1 Doug Alsop STA 54.30, 2 Kevin Burnett NRR 56.44, 3 Richard Pearson U 58.30. 65-69: 1 Ian Ringer ECH 57.06, 2 Roger Nosworthy BR 69.12, 3 Barry Drew CR 70.36.
70+: 1 Tony Berry TRC 61.57, 2 Nick Jeans TRC 64.34, 3 Howard Haynes HR 68.23. Teams: 1 St Austell Running Club 132 points, 2 Falmouth Road Runners 179 points, 3 Cornwall AC 190 points.
Ladies: 1 Jasmine Finney BR 47.31, 2 Zoe Barber WH 48.11, 3 Revis Crowle ECH 51.29, 4 Debbie Harrison HR 52.05, 5 Emma Murray STA 52.31, 6 Sharon Daw ECH 52.48.
Age Categories: Under 35: 1 Jasmine Finney, 2 Zoe Barber, 3 Louise Hawkins ECH 58.29. 35-39: 1 Helen Heard BR 53.57, 2 Ann Quarmby U 58.07, 3 Olivia Pellowe CR 61.45. 40-44: 1 Debbie Harrison, 2 Emily Young ECH 55.08, 3 Angela Martin BR 55.33. 45-49: 1 Emma Murray, 2 Sharon Daw, 3 Emer Scanlon TAV 54.55. 50-54: 1 Revis Crowle, 2 Julie Towers LRR 59.35, 3 Jeanette Duncan G&G 61.02. 55-59: 1 Sue Ogilvie NRR 55.56, 2 Janet Watson FRR 58.19, 3 Alison Joslin TRC 65.59. 60-64: 1 Bridget Funnell BR 59.35, 2 Mary Mullarkey ECH 70.35. Teams: 1 East Cornwall Harriers 34 points, 2 Bude Rats 38 points, 3 Falmouth Road Runners 100 points.
Despite very unseasonable weather, Truro Tennis Club's annual open LTA Grade 3 tournament went ahead on schedule.
With more than 170 entries and more than 200 matches played during the week spectators saw some exceptional talent across the age groups from U8 to senior level.
The club played host to LTA chief executive Roger Draper and his family, who were holidaying in Cornwall while taking part in the tournament.
Play started on the Sunday with the U9 Orange ball event and the standard of play was high and there was a good representation from Cornwall, with players taking place from all over the county and nationwide.
The Boys' event went with the seedings with No.1 Taylor Ingham-Hill eventually beating No.2 seed Ben Rowe.
The girls U9 event was won by Emily Syms. In the Red ball U8 event the winner in the girls draw was Daisy Chapman, runner-up Lolita Winter-Smith.
The boys' event was won by Zac Brown, and runner-up Sonny Poulter. The under 10 green ball was won by No.1 seed Fergus Jacobs.
In the Under 12s Tony Pryce events, Cornwall showed their strength with a great performance by Arielle Fitkin who went on to win the girls event.
The boys' draw of 23 was fought hard with the eventual winner being top seed Jack Draper, who beat Sebastian Harris in the final.
The U14 event was won by Louis Newman, runner-up was Julian Robinson. The girls was won by A Brooks with runner-up Rebekah Oloughlin.
There was more success in the doubles for the Draper boys as they went on to win the U14 doubles event and the girls pairing of Arielle Fitkin and Rebekah Oloughlin won the Girls' U14 doubles. The U16 John Hampshire Perpetual Cup was won by Cem Ortel, runner-up Emerson Styles.
The U18 boys winner was Ben Tyrrell, who beat Jake Horton in a close fought match 6-3, 6-3 and the girls winner again Alisa Cole with Amy Johns the runner-up.
In the senior women's singles, No.2 seed Isabella Brown played well to overcome top seed India Rojano in a thrilling tie break.
The men's singles was won by Ben Tyrell, who beat Conor Polyblank in the final.
The mixed doubles saw Conor Polyblank and India Rojano overcoming No1 seeds Finn Leverton and Amy Johns 6-3,7-5 .
The men's doubles saw No2 seeds Roger Draper and his son Ben playing No1 seeds, Truro's Kieron Butter, and Oscar Newman from Middlesex.
The top seeds took a two-game lead breaking early but it did not take long for Roger Draper, an accomplished doubles player, to find his rhythm and bring the set to 3-3. The boys were not able to overcome Roger's consistency at the net and Ben's defensive play and after a well-played and hard fought match the final score was 6-3,6-2.
All the senior doubles were sponsored by The Heron Inn at Malpas. Truro Lawn Tennis Club would like to thank all their sponsors for supporting the event. If you wish to find out more about the club and coaching available and upcoming tournaments please see the website www.truroltc.com


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Hotels in 53267 - Milwaukee WI
Only hotels in 53267 zip code are listed below. Search for cheap and discount hotel rates in Milwaukee, WI for your upcoming leisure or conference / group travel. We list the best 53267 hotels and motels so you can review the Milwaukee hotel list below to find the perfect lodging. Hotels in Milwaukee county and area code 414 are also listed.
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Casa Pacifica
Residence #4
El Cortijo Development
Costa Esmeralda
Region of San Carlos
Information Request
Rates & Availability
Accommodations: Villa - 8 Bedrooms all with en-suite baths; plus 3 - ˝ baths
3 Bedrooms have 2 double beds
5 bedrooms have 2 twin beds
Our vacation Villa is located in a 14 residence luxury gated community on a hillside
overlooking the beautiful Pacific Ocean in Panama. Spend your vacation lounging at our
large private pool, snoozing in handy hammocks, reading by the pool, visiting the Panamanian
market at El Valle in the middle of an extinct volcano, enjoying mountain hikes in the rain forests,
or strolling along the deserted beach. The Villa is only minutes from restaurants serving a
variety of low cost, high quality local and international cuisine. Evenings can be spent
reading in the Library, watching satellite TV, or just lying by the pool soaking up the starlit skies.
The Villa is easily accessible, being just off the Panamerican Highway, an easy 1 hour drive west
of the Bridge of the Americas at the mouth of the Panama Canal.