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I am now a rsvp holder for the Model S as of this morning.
I saw the Tesla S in person in Los Angeles and I was impressed and compelled to get one.
Honestly, it's beautiful. There's not much I would change given the chance.
We were not able to get into it and I was told the interior was not at all final.
I was expecting the car to be bigger and for those interested in the 3rd row back seats...forgetta' bout it.
I'm not sure who would stick 2 children back there but there's definitely no head room for even a teenager.
I asked about the front grille and got sort of a vague answer about Alpha build and aluminum piece fitting being the primary goal at this stage. I inquired about the difference between what I was seeing in person and the video of the Alpha. That's the answer I got. it looks like they intend to keep the grille as we see it.
I think the primary issue I'm concerned mostly about is the cost and I'm hoping that the Federal and California tax credits will be there by the time I get my car. It's not a given. This car is still expensive.
lastly, on a side note that is somewhat related....I found out from a co-worker today that a guy here at my work who ordered a Nissan Leaf was looking at his order status and it went from months to suspended indefinitely. You guessed it, the Japan crisis has completely disrupted the deliverables for cars out of Japan. I'm assuming this won't affect Tesla since the S is being built from the ground up in CA, but it may help in getting to the tax credits before Leaf owners do now that their cars are being affected.
In any case, I'm excited. I'm rsvp holder around 3400 in case that means anything to anyone?
Sales rep told me they had about 5000 rsvps so far for the S.
Congratulations, you might want to check out this web site: http://www.teslamotorsclub.com/ They discuss everything related to EV's and as the name indicates, specifically Tesla. The Model S area has some neat photos and links to photos of the Alpha build. Happy searching!
kenji.sweeney@g... -
Congratulations! What is your reservation number?
Question: your post was unclear. Is the grill "as we see it" closer to the Alpha or the prototype? I'm hoping the prototype.
Also, Tesla has not been affected by the crisis in Japan.
"So far there's been no impact on Tesla's operations from the earthquake, tsunami and nuclear power plant crisis in Japan that has temporarily halted some production there, Straubel said."
I think I am in the 3400's. It just says Model S #34XX. I don't want to say exact number.
is that what you mean? I wish I had a meaningful way to know what number that is in my area in terms of how many people in LA have reserved.
As for the grille, I mean the way it looks on the website. The Alpha video shows a blacked out shield over the mouth. I believe the grille with the chrome bars and "T" for tesla is the intended design.
Feel free to share your exact number, we have an entire thread where everyone shares their number.
It's forum "New Model S Reservation Holder"
The rear-facing seats are intended for <10yr.-olds. Teens are >12yrs. old. So, not relevant.
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|Pascal Arquitectos - ACBC Office in Mexico City
|Friday, 04 June 2010 07:01
This office project was designed for a shopping center developer. The initial concept was to create very functional and contemporary headquarters. The design intention was to build, through the language and the atmosphere, an architecture completely aside from the traditional / institutional one, based on the premise of the workplace as a second home where workers spent most of our time.
Photographs by Jaime Navarro
A mix of natural materials such as marble and wood, in contrast with colored tempered glass, stainless steel and iron, created balanced color and textures compositions and at the same time a combination between modern design and a warm ambiance.
In the elevators entrance hall the difference between the white Calacata marble and the black steel plates causes a sort of contradictory effect. This access leads to the reception foyer that changes to an elegant and warm tones atmosphere through its lighting; in this area: Rosso Levanto marble, Papagayo wood wall panelling and a black crystal glass with a floating LCD screen that temporarily appears and disappears.
Related Articles:
|Last Updated on Thursday, 26 May 2011 11:17

subset: commoncrawl


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Jon Gosselin was spotted tubbing at Sundance…and he's never looked better! Woops, that's Ryan Gosling in the photo, who was tubing in Utah yesterday to promote Blue Valentine (Gosselin, who may or may not be tubbing, is only at the Festival to raid gifting lounges). Valentine, a non-chronoligical chronicle of a modern marriage, is the Oscar nominee's first movie in over two years, following his dismissal from The Lovely Bones (way to dodge that bullet) and time spent singing along with Silverlake children's choirs in his indie group Dead Man's Bones. Michelle Williams—who plays Gosling's wife in the film—also braved the winter cold for the party, though sadly she did not join Gosling and 5-year-old co-star Faith Wladyka in the snowy sporting. Watch the fun in the gallery below.
[Photo: WireImage]


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When Muscle Milk Pickett Racing hit trouble, it was clear sailing for Rebellion Racing, which scored back-to-back Petit Le Mans victories and took top overall honors in the final American Le Mans Series race.
The day also belonged to Level 5 Motorsports and owner/driver Scott Tucker, who claimed his fourth drivers' championship with a win in the P2 class.
BAR1 Motorsports earned top honors in Prototype Challenge, but it was PR1/Mathiasen Motorsports' Mike Guasch that took the drivers' title by a single point, while CORE autosport locked up its third consecutive teams' title.ALMS, Rebellion Racing, Sports Cars


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Symposium on "Vietnam and the Major Powers" to Be Held at Pomona College
Pomona College will host a symposium on "Vietnam and the Major Powers" on Tuesday, February 21, 2006 at 4:15 p.m. in room 208 of the Smith Campus Center (170 E. Sixth St., Claremont).
The program will focus on Vietnam's contemporary relations with the major powers in Asia and the United States. The speakers include David Arase and David Elliott, of Pomona College; Arthur Rosenbaum of Claremont McKenna College; and Quang Minh Pham, a professor of International Studies at Vietnam National University-Hanoi.
Arase is an expert on East Asian security relations and economic cooperation and an associate professor of politics at Pomona College. He is the author of Buying Power: The Political Economy of Japanese Foreign Aid (1995) and editor of the book Japan's Development Assistance (2005).
Elliott is the H. Russell Professor of International Relations and a professor of politics at Pomona. A leading expert on the Vietnam War and asian security Issues, he is the author of the widely praised volume The Vietnamese War: Revolution and Social Change in the Mekong Delta.
Rosenbaum is an associate professor of East Asian history and chair of the Asian Studies Department at Claremont McKenna College, where he teaches courses on Modern Chinese History and Asia in the Modern Era.
Quang Minh Pham will serve as a presentation discussant and offer concluding remarks. Pham comes to Pomona College as part of a year-long Vietnam Exchange Program grant from the Luce Foundation/ALCS.
The symposium is sponsored by the Pomona College Asian Studies Program and is open to the public. For more information, call (909) 621-8933.
Pomona College, one of the nation's premier liberal arts institutions, offers a comprehensive program in the arts, humanities, social sciences and natural sciences. Its hallmarks include small classes, close relationships between students and faculty, and a range of opportunities for student research.


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Confidential services, including non-medical counseling and specialty consultations, are available through Military OneSource. Eligible individuals may receive confidential services at no cost. Check eligibility. International Calling Options.
Log in to your Military OneSource account to access online counseling services.
Click here to access confidential non-medical counseling and resources to balance and improve work performance and overall health.
In July, Military OneSource can help you be ready for change.
If you would like to become a blogger for Blog Brigade, click the link below to find out how!.
While your partner is deployed and you are home with the children, there may be times when you feel like a single parent. Although the situation is temporary, there are emotional, financial and practical day-to-day adjustments you will need to make as you cope with this transition. How can you calm your children's fears about their parent when you are worried, too? Where will you turn when you need help? The information below will help you adjust to life as a temporarily single parent.
Adjusting to life while your partner is deployed should go more smoothly if you take some time beforehand to think through and discuss some of the issues you may face. Try to anticipate what might happen and put systems in place to make it easier.
A deployment can bring out a range of strong emotions, and some of them may seem in direct conflict with each other. You may miss your partner terribly, yet at the same time resent his or her freedom from family responsibilities. Be aware that all of your feelings are normal reactions to a difficult situation and there is support available for you and your family.
Children may react to a parent's deployment as they would a more permanent separation. They may worry about what will happen to them and be afraid that the parent at home will leave, too. The following are ways to help:
Simplify your life as much as you can. You may feel you're short on one key ingredient - time. Raising a child, working and managing a household can be very hectic, but if you take steps to simplify your life, you may find it easier to cope. The following are some tips for simplifying your life:
Don't forget to take care of yourself. If you get enough sleep and exercise and eat well, the adjustment to life with your partner away will be easier for you and your child.
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Service members, family members, surviving family members, service providers and leaders rely on Military OneSource for policy, procedures, timely articles, cutting-edge social media tools and support. All in one place, empowering our military community.
Release 06.30.15.1.22.214.171.124.2


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FORT GIBSON — In a game that was about as back and forth as one could get, it was the Poteau Pirates who came out on the short end of the stick in Friday night's District 4A-4 road game against the Fort Gibson Tigers.
After 70 points were put up in the first half, 85 points were added in the second half. But the bad news for the Pirates was that three more of those points were put up by the Tigers as they outlasted the Pirates 59-56.
PANAMA — The Panama Razorbacks came out for the second straight week and played a tough game against another county team.
But unlike last week's victory over archrival Pocola, in the end, this week it wasn't enough.
The Heavener Wolves would take home the victory in the fourth quarter by a final score of 28-14 in a crucial District 2A-6 contest Friday night at George Ollie Stadium.
ARKOMA — The Arkoma Mustangs took care of busines quickly Friday night at Mustang Field, mercy ruling the Bokoshe Tigers 46-0 with just over three minutes left in the first half.
SPIRO — The Spiro Bulldogs kept their slim playoff hopes alive Friday night as they defeated the Atoka Wampus Cats 23-7 in their home finale at McClain Stadium.
TALIHINA — There will not be any postseason games this season for the Talihina Golden Tigers.
The Golden Tigers ended their home regular season with a heartbreaking 27-21 loss to the Hartshorne Miners Friday night at Doc Robinson Stadium.
The Pansy Kidd Middle School eighth-grade football team wrapped up a perfect 7-0 season with a 24-0 win over the Fort Gibson Tigers on a rainy, cold Thursday night at Costner Stadium.
But the Poteau freshmen and PKMS seventh-graders suffered losses. The Pirate freshmen lost 22-16, while the seventh-graders fell 24-0.


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Welcome to the Economic Development website
The Economic Development information website contains information on a range of economic issues including information technology, energy, tourism, regulatory reform, and commerce. The site is owned by the Ministry of Business, Innovation and Employment.
Energy data
Access the latest energy data for New Zealand or download one of our publications.
Food and Beverage Information Project
The Food and Beverage Information Project is the first comprehensive overview of the state of New Zealand's food and beverage industry.
Tourism research and data
Access a wide range of information on domestic and international tourism, and the economic impacts of tourism.
Ask a question Answers to frequently asked questions
Growing the economy
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Click Here to Watch the Whole Video in HD at Next Door Ebony
Enjoy the natural beauty of these amazingly ripped gay black men while they partake in hardcore all-male action.
Tyce Jax and returning Ebony star, Kiern Duecan, are coming together to let passion explode. Tyce is a well-built, sexy guy whos insatiable when it comes to dudes like Kiern. Theyre starting out with some very hot kissing, letting their fattened dicks rub together from underneath their respective pairs of underwear. Tyce goes to his knees and unleashes Kierns large, uncut cock. He doesnt waste any time taking the throbbing dick deep, licking and sucking Kierns balls as well. Then they move to the bed where Kiern pulls out Tyces piece and enjoys it thoroughly with some sucking and bobbing of his own. They move into the 69 position so Kiern can lick Tyces sweet hole while Tyce continues devouring Kierns erection. And once Tyces ass is nice and wet, Tyce climbs on Kierns behemoth cock and rides it hard. Then Kiern repositions so he can slam Tyce while jerking his fat dick too. Get ready to experience extremely hot action as these two powerful men exchange steaming-hot sexual energy in thi
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One man has managed to use up more ink than Lindsay Lohan's nails, Mel Gibson's rants and The Bachelor's breakups: LeBron James.
The NBA's hottest (better said: most hyped) free agent sure took his sweeeeeet time making up his mind about where he'll lay his, um, hightops. And we're seriously happy it's with the Miami Heat. OK, we don't want to be too greedy - the team already nabbed Dwyane Wade and Chris Bosh - but the Magic City can use someone with Shaq-esque star power. This guy's got that to spare. The erstwhile Cleveland Cavalier, 25, is known just as much for his off court activities.
LeBron is a fun, provocative, I-like-to-push-your-buttons kinda dude.
In 2007, the fame seeker hit Saturday Night Live. Among his highlights: camping it up in an '80s wig and a gold metallic suit as a Solid Gold dancer. For a guy with no acting background it was pretty funny stuff. We like.
In 2008, James managed to ruffle a few sensitive feathers when he posed along with supermodel Gisele on the cover of Vogue. The shot made history as the first time the tony monthly had featured a black man on the cover (what happened to Andre Leon Talley? - but that's another story). Critics likened Annie Leibovitz's image to King Kong and Fay Wray. But hey, it got people talking - and he was well aware.
"Everything my name is on is going to be criticized in a good way or bad way," James said at the time. "Who cares what anyone says?"
A year later the buff basketball player shot a video for the Drake song Forever - featured on the the soundtrack to LB's documentary More Than A Game at the Fontainebleau Miami Beach. He also suited up in GQ - the guy cleans up nice. On his terms.
Speaking of terms, James took a $30 million paycut (the Cavs have offered him a six-year, $128 million contract, while Miami signed him to a five-year deal worth $99 million).
Still, his momma didn't raise no fool - King James is in the prime of his life - perfect for our crazy town. UsWeekly has him already renting out six cabanas at the W Hotel South Beach this weekend to celebrate. Do they even have cabanas in Cleveland?
Though the Akron, Ohio, native likely won't live on the wild side on the beach - rumors place him househunting tree lined mansions in low key Coral Gables. Granted, he does have a girlfriend - has for a while. Savannah Brinson is also the mother of his two sons, 3-year-old Bryce and 5-year-old Lebron Jr. That may keep him in check (or not, see Shaq's history).
One concession he may have to make - take off the Yankees cap, dude. You're in Marlins country now.
Welcome him to town yourself: James just joined Twitter @KingJames.
[1] http://www.miami.com/on-our-radar
[2] http://www.usmagazine.com/moviestvmusic/news/lebron-james-plans-weekend-party-in-south-beach-201087
[3] http://www.miami.com/lila-nikole039s-pop-shop-hyde-beach-article
[4] http://www.miami.com/havana-nights-regent-disco-inferno-20-cameo-art-auction-wynwood-amp-full-moon-celebrations-article
[5] http://www.miami.com/nightlife/velvet-underground
[6] http://www.miami.com/could-be-best-place-get-beer-miami-concrete-beach-brewery-article
[7] http://www.miami.com/clink
[8] http://www.miami.com/once-blue-moon-parties-friday-article
[9] http://www.miami.com/singer-bea-miller-just-getting-started-article
[10] http://www.miami.com/local-chef-appearing-nbc-show-article
[11] http://www.miami.com/real-housewives-oc-star-miami-article
[12] http://www.miami.com/fifth-harmony-has-miami-connection-article
[13] http://www.miami.com/vape-shops-popping-everywhere-article
[14] http://www.miami.com/watch-model-charlotte-mckinney-enjoy-miami-during-swim-week-20-seconds-article
[15] http://www.miami.com/eva-mendes-personal-appearance-aventura-article
[16] http://www.miami.com/folk-night-moca-article
[17] http://www.miami.com/love-story-part-2-ryan-o039-neal-ali-mcgraw-together-again-article


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Balloons, aerials, babies, paint and air kicks. Native Shoes was in NYC with Tim Barber to shoot the SS11 catalogue.
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Jonathan Harvey joined the Georgia soccer staff in February 2011 as a volunteer coach and works primarily with the goalkeepers. He helped All-SEC and All-Region keeper Ashley Baker finish her career in the Bulldog record books in nearly every category, going on to sign a professional contract in England and earn a call-up to the Senior National Team's camp following her time at Georgia and with Harvey.
Harvey returns home to Athens after five successful seasons as an assistant coach and recruiting coordinator at NCAA Division II North Georgia College and State University in Dahlonega, Ga. Harvey helped the Lady Saints to a 48-34-8 record in his five seasons, a stint that culminated in 2010 with the program's first ever NSCAA Top-25 ranking and finish as the Peachbelt Conference Tournament runner-up.
As the assistant at North Georgia, Harvey was instrumental in lowering the Saints' goals-against average from 1.79 in 2005 to 1.03 in 2010, a program-best. While at NGCSU, Harvey recruited and trained 13 PBC All-Conference performers, five NSCAA All-Southeast Region selections, and one NSCAA All-American and PBC Freshman of the Year. Harvey worked closely with head coach Chris Adams on day-to-day operations, practice planning, fundraising, travel, and recruiting.
Harvey is no stranger to youth soccer in Georgia having served as Georgia ODP Staff Coach for the 92 and 96 Girls teams. Harvey has also trained goalkeepers at United Futbol Academy and Gwinnett Soccer Association over theprevious two years. He is on staff at Last Defense Goalkeeping Academy in Atlanta, which provides specific technical and tactical training for goalkeepers. Harvey has extensive summer camp experience as well having been on staff at Clemson Soccer Camp, Western Carolina Soccer Camp, and the University of Georgia Soccer Camps.
Harvey played his collegiate soccerat Oglethorpe University and also served in the United States Navy from 2000-2005. This stint in the Navy included decorated combat tours in the Al Anbar Province, Iraq, in 2004 and 2005.
Harvey holds the USSF B License, NSCAA Levels I, II, and III Goalkeeping Diplomas.A native of Athens, Ga., Harvey earned his bachelor's degree in political science form North Georgia College and State University. He is married to the former Raegan Yeomans of Jesup, Ga., a graduate of the University of Georgia.


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The invention provides a balloon of non-elastomeric material which is spirally wrapped onto the main body of the catheter. The catheter is inserted in this condition and on inflation, the balloon aligns itself with the axis of the main body causing the body within the balloon to twist and store energy which is available for collapsing the balloon after use.
1. An angioplasty catheter comprising:
an elongate tubular main body having proximal and distal ends and including a fluid supply lumen extending longitudinally, and a side opening in the main body adjacent the distal end, the lumen terminating at the side opening;
a balloon of non-elastomeric material having ends spaced apart and attached at the ends of the balloon to the main body with one of the ends adjacent said distal end and the balloon containing the side opening, the balloon being twisted spirally between said ends of the balloon to store the balloon close to the main body in a collapsed condition; and
the main body being resiliently deformable within the balloon when the balloon is inflated to thereby store torsional energy in the main body for use in returning the balloon to the collapsed condition during deflation of the balloon.
2. An angioplasty catheter as claimed in claim 1 and further comprising radiopaque bands on the main body and adjacent ends of the balloon to define the location of the balloon during insertion procedures.
3. An angioplasty catheter as claimed in claim 1 in which the main body further defines a guide wire lumen extending in parallel with the fluid supply lumen and extending between the proximal and distal ends of the catheter.
4. An angioplasty catheter as claimed in claim 3 and further comprising a connection piece at the proximal end of the main body and guide wire and fluid supply tubes coupled to said piece for communication between the guide wire and fluid supply tubes and the respective guide wire and supply lumens.
5. An angioplasty catheter as claimed in claim 4 in which the main body, and the guide wire and fluid supply lumens are of circular cross-section.
6. An angioplasty catheter as claimed in claim 5 in which the said distal end of the main body is tapered and the guide wire lumen terminates centrally of the tapered end.
7. An angioplasty catheter comprising:
an elongate tubular main body having proximal and distal ends and defining guide wire and fluid supply lumens, and a tapered tip at the distal end, the fluid supply lumen being closed at the tip and the guide wire lumen extending to the tip for receiving a wire to guide the catheter during insertion procedures, a side opening in the main body at the end of the supply lumen near the tip;
a balloon sealed to the main body near the tip and containing said side opening, the balloon being of a non-elastomeric material and having a defined shape when inflated from a collapsed condition to the inflated condition by fluid pressure applied through the supply lumen, the balloon being twisted when assembled on the main body, so that on inflation the main body will be twisted thereby storing energy for use in restoring the balloon to the collapsed condition;
a portion of larger cross-section at the proximal end of the main body and formed integrally with the main body of thermoplastic material, said portion being an extrusion and the main body being formed from the extrusion by drawing the extrusion through a heated die while supporting the lumens to give the main body a reduced cross-section, longitudinal molecular orientation, and enhanced surface smoothness;
a connection piece at the proximal end of said portion and coupled to said portion; and guide wire and fluid supply tubes coupled to the connection piece in communication with the respective guide wire and fluid supply lumens.
8. A method of making an angioplasty catheter having an elongate tubular main body including proximal and distal ends and containing a guide wire lumen and a fluid supply lumen, and a balloon attached to the main body in fluid communication with the fluid supply lumen to inflate the balloon, the method comprising selecting a main body including at least a portion adjacent the distal end having torsional flexibility, attaching an inextensible balloon to the main body to contain at least part of said portion, the balloon being twisted spirally before attachment for maintaining a collapsed condition prior to use, whereby on pressurising the by passing fluid down the fluid supply lumen, the balloon will inflate straightening as it inflates and thereby twisting said portion to store energy which is available to return the balloon to the collapsed condition.
This invention relates to angioplasty catheters for use in the treatment of stenosed blood vessels. The invention also relates to a method of manufacturing the catheter.
An angioplasty catheter is typically elongate and tubular, and is provided with a balloon near or at its distal end and radiopaque bands defining the extremities of the balloon. The catheter is inserted at a convenient location and fed into the stenosed blood vessel until the balloon is located in the narrowed portion of the blood vessel. Fluid from an external supply is then used to inflate the balloon such that it compresses the obstructing plaque and stretches the plaque coated walls of the blood vessel. When the physician is satisfied that the blood vessel has been widened sufficiently, the balloon is deflated and the catheter removed.
Angioplasty catheters have been successfully used for a number of years in the treatment of blood vessels obstructed or stenosed with plaque. An angioplasty catheter includes, near its distal end, a balloon which can be inflated by means of pressurized fluid supplied through a lumen in the catheter. The treatment involves the location of the balloon in the stenosed section of the blood vessel, followed by inflation and deflation. During inflation, the balloon compresses the plaque and stretches the blood vessel such that the cross-sectional area of the stenosis is increased until it is comparable to that of the unobstructed blood vessel. When the treatment has been completed the balloon is deflated and the catheter removed. The treated blood vessel maintains substantially its enlarged cross-section to permit the free flow of blood through this portion.
To perform satisfactorily a suitable angioplasty catheter must possess a number of properties. For ease of insertion it is preferable that the catheter is flexible, has a relatively small cross-sectional area, and has a smooth outer surface. Also, the method of insertion of the catheter has a significant bearing on the form of the catheter. The catheter which is the subject of the present invention is intended for insertion using the Seldinger technique and therefore preferably has a tapered end and a lumen to receive the Seldinger guide wire. The catheter ends at an aperture in the tapered end substantially coaxially with the main body of the catheter. However, perhaps the most important part of the catheter is the balloon which must be strong enough to withstand the application of high pressures without rupture and which must always inflate to a predetermined shape and size.
Also, during insertion and removal, the balloon must present a small profile as it is moved longitudinally.
It has long been accepted that in order to reduce the balloon profile during insertion, the balloon must be wrapped in some way about the body. An example of a typical structure intended for this purpose is found in U.S. Pat. No. 4,338,942 to Fogarty. The balloon is attached to an internal rod which has an exposed control knob at the proximal end of the catheter. On turning the knob, the balloon is rotated at the distal end to impart a twist which wraps the balloon on the main body. There is no energy stored other than possibly in the balloon. After insertion, the twist is removed to allow inflation and then, to permit removal, the twist is again applied. This structure is rather complex and requires a long rod through the length of the device. Further, this structure is not suitable for insertion using the Seldinger technique.
Another exemplary structure which uses a mechanical wrapping device is shown in U.S. Pat. No. 4,646,719 to Neuman et al. A tube runs the length of the device to permit Seldinger insertion through the tube and this tube can be rotated to wrap the balloon against the resistance of a spring. After insertion, the spring energy can return the balloon to its normal position for inflation. During insertion the balloon must be kept in the wrapped condition against the urging of the spring which will tend to unwrap the balloon.
A different approach is taught in U.S. Pat. No. 4,402,307 to Hanson et al. A balloon is provided which is attached at its distal end to a tubular central member which extends along the length of the catheter. A tool is provided for engaging the distal end to rotate that end and wrap the balloon around the tube as energy is stored in the twisted tube. Provided that sufficient vacuum is applied, the balloon will remain in this condition during insertion. Should there be any difficulty with the vacuum then of course the balloon will unwrap itself under the influence of the tube returning to its normal condition. After insertion, the balloon is released and can not be wrapped again in the same fashion in which it was wrapped in the first place. However access is provided to the tube at the proximal end for rotating the tube which will presumably wrap the balloon in the fashion taught by Fogarty.
All of the prior art structures suffer from serious disadvantages and among them are complexity, dangerous situations arising should vacuum fail during insertion, and such difficulties as unwrapping the balloon accurately to ensure that it is in the proper position for inflation after it is located in the patient.
It is an object of the present invention to provide an improved angioplasty catheter which overcomes some of the disadvantages of the prior art.
The invention provides a balloon of non-elastomeric material which is spirally wrapped onto the main body of the catheter. The catheter is inserted in this condition and on inflation, the balloon aligns itself with the axis of the main body causing the body within the balloon to twist and store energy which is available for collapsing the balloon after use.
FIG. 1 is a perspective view of an angioplasty catheter in accordance with a preferred embodiment of the present invention;
FIG. 2 is an enlarged isometric view of a balloon forming part of the catheter;
FIG. 3 is a sectional view on line 3--3 of FIG. 1;
FIG. 4 is a sectional view on line 4--4 of FIG. 1;
FIG. 5 is a diagrammatic sectional view illustrating the drawing of the main body to reduce cross-section and to change the physical characteristics of the main body of the catheter;
FIG. 6 is a sectional view illustrating the method of manufacturing a tip on the catheter;
FIG. 7 is a diagrammatic sectional view illustrating a method of manufacturing the balloon;
FIGS. 8 to 12 are views, mostly in section, illustrating the method of manufacturing the junction at the proximal end where tubes provide access for a Seldinger wire and for providing a supply of fluid to inflate the balloon; and
FIGS. 13 and 14 are diagrammatic views illustrating the operation of the balloon as it moves from a collapsed to an inflated condition.
The preferred embodiment of the angioplasty catheter according to the present invention will now be described in detail, firstly with reference to FIG. 1 of the drawings. This view shows in perspective an angioplasty catheter, designated generally by the numeral 20, including a flexible main body 22 having a distal end or tip 24 defining a tapered tip 25 to facilitate insertion into a vein of a patient, and a proximal end 26 for connection, by means of connection piece 28, to the respective distal ends of a guide wire tube 30 and a fluid supply tube 32. The tubes 30, 32 are in communication with respective circular guide wire and fluid supply lumens 34, 36 defined within the main body 22 (FIG. 3) and are provided with luer fittings 35, 37 at the respective proximal ends. Different colored marking sleeves 38, 39 help distinguish the tubes from one another (although in practice the fluid supply lumen 36 is of significantly smaller cross-section than lumen 34).
The body 22 extends from the connection piece 28 to the tip 24 and passes through a balloon 40, details of which are provided below. A tubular shipping protector (not shown) for location over the distal end 24 and balloon 40 would normally be provided to protect the balloon and to retain it in a collapsed condition ready for insertion.
Reference is now made to FIG. 2 of the drawings which shows the distal end of the catheter in greater detail with the balloon in a collapsed condition. The balloon 40, located at the distal end 24, is formed of a Nylon membrane which is flexible and substantially inextensible (i.e. not elastomeric) and, when inflated, is in the form of a cylinder having tapering ends (as indicated in ghost outline). The distal and proximal ends 46, 48 of the membrane locate snugly over the distal end 24 of the main body 22 with the distal end 46 being mated to the body just short of the tapered tip 25. A side opening or aperture 50 in the wall of the main body 22 provides fluid communication between the smaller fluid supply lumen 36 and the interior of the balloon 40 between the body 22 and the membrane of the balloon.
A pair of radiopaque bands 54, 55 are attached around the body 22 inside the balloon 40 and near the ends 46, 48 for monitoring the position of the balloon.
To inflate the balloon 40, fluid is supplied under pressure through the fluid supply tube 32 and the fluid supply lumen 36, and then through the aperture 50 into the balloon 40. Thus, the balloon is pushed radially outwardly by the fluid pressure to assume the shape shown by the chain-dotted lines in FIG. 2, so that the balloon 40 has a diameter greater than that of the main body 22. On deflation, and on withdrawing the fluid by suction (i.e. negative pressure) the balloon folds and collapses to lie close to the outer surface of the body, as shown in FIGS. 2 and 4.
Reference is next made to FIG. 5 which illustrates diagrammatically how the main body 22 is drawn down. As seen in FIG. 1, the main body meets, adjacent the connection piece 28, a short portion 56 of larger diameter than the main body 22. This corresponds to the diameter at portion 58 in FIG. 5 and a diameter 60 corresponds to that of the main body. The purpose of this reduction in diameter will be explained in more detail later but for the moment it is sufficient to understand how it is accomplished. A length of extruded Nylon having a cross-section similar to that shown in FIG. 3, but of the diameter of portion 58, is first cut to remove some material to leave a leading end piece 62. This piece is small enough to pass readily through an opening 64 in a heated die 66. A pair of supporting rods 68, 70 are engaged in the respective lumens 34, 36 (FIG. 3) and have proportions corresponding to the required sizes of these lumens as drawn in FIG. 3. Of course the rods will be loose in the original extrusion because it is of larger size than the body 22.
The die 66 includes a conical lead-in portion 72 which blends smoothly into the polished opening 64, and at the outlet, a rounded nose portion 74 is provided so that after extrusion, the body can be drawn backwards through the die to remove it.
After cutting the extrusion to provide the end piece 62, the rods 68, 70 are engaged and the end piece 62 fed through the heated die to be used to draw the remaining extrusion through the die. This drawing process takes place to effectively orientate molecular structure, improve the surface finish, and enhance the density of the Nylon to give it better torsional stiffness and strength. This continues in the manner illustrated in FIG. 5 until the portion 56 (FIG. 1) is reached, at which point the drawing is discontinued and the body is withdrawn in the opposite direction from the die 66. An end part, including the leading end piece 62, is cut off the extrusion leaving only the required part of the body. The length of the catheter can be fixed at this stage.
The next step in the process is to form the tip 25 (FIG. 1) and the method of doing this is illustrated diagrammatically in FIG. 6. Here a heated die 76 has an internal shape corresponding to that of the required tip and an opening 78 aligned with the tip to receive an end part of the mandrel 80 which is engaged through the guide wire tube of the body. A rod or mandrel 82 is provided in the fluid supply tube and, under the influence of heat from the die 76, the body is advanced into the die and deformed into the shape shown in FIG. 6. It will be seen in this FIG. that the fluid supply tube has been terminated at its end whereas the guide wire tube has been retained in an open condition to provide access for the Seldinger wire during insertion. The form of the structure is such that the end is conical so that the Seldinger wire is centered relative to the catheter during insertion.
As a separate procedure, a membrane is formed to be used to make the balloon. This procedure is illustrated diagrammatically in FIG. 7. A tube of Nylon having a wall diameter thickness of about 0.015 inches is located in a copper mould 84 made up of two halves 86, 88. The tube 56 is cut at a lower end 90 and a clamp 92 is attached to a short end piece 94 which extends from the mould 84 to seal the end of the tube and to ensure that the tube is not pulled from the mould. The tube and mould are then suspended in a heated oil bath 96 at about 170� to 175� C. for three minutes. The total weight of the mould and accessories is about 150 gm. and this weight tends to stretch the heated tube such that the molecular orientation becomes axial along the length of the tube.
After three minutes in the oil bath 96 a pressure of 400 p.s.i. is applied to the inside of the tube from an external supply (not shown) causing it deform to occupy the interior of the mould, oil in the mould being pushed from the mould through relief holes 98. After a short interval of time the pressure is released and the mould containing the resulting membrane 100 is removed from the oil bath and placed in freon which acts as a coolant and disperses the oil. The membrane retains the tapered cylindrical shape of the mould, the deformed portion having a wall thickness in the order of 0.00025 to 0.0005 inches.
Reference is next made to FIG. 8 which is the first of a series of FIGS. 8 to 12 demonstrating the manufacture of the connection piece 28 shown in FIG. 1. The portion 56 of the main body is held in place to receive, under the influence of some heat, a pair of mandrels 102, 104. These mandrels have leading ends corresponding to the sizes of the respective guide wire tube 30 and fluid supply tube 32, and leading end portions 106, 108 are conical with the axis inclined as indicated by the chain dotted center lines to meet cylindrical portions 110, 112 of the mandrels. This arrangement is necessary since they are to be used to form an end of the main body and deformation can only take place outwardly. The mandrels are entered into the lumens 34, 36 to the position shown generally in FIG. 9 where it will be seen that the ends of the lumens have been flared. Next, and as seen in FIG. 10 diagrammatically, the distal ends of the respective guide wire tube 30 and fluid supply tube 32 are engaged in the flared ends of the lumens 34, 36 followed by a pair of suitably proportioned mandrels 114, 116 which are engaged through the tubes and into the body portion 56. The tubes and body are of Nylon which is a thermoplastic material so that deformation of these parts can be achieved to bring them together in a single assembly.
As seen in FIG. 11, a thin sleeve 118, of a Nylon material is engaged over the body portion 56 and extending outwardly beyond this portion terminating around the tubes 30, 32. Over this is applied a heavy sleeve 120 of silicon rubber which is stretched into place. The assembly is then heated and compressed in a suitable clamping arrangement such as a pair of formed die halves (not shown) to bring the materials into flowing engagement with the mandrels and to seal the Nylon parts to one another. The silicon rubber sleeve 120 helps to distribute the load and to apply a circumferential compressive loading on the parts to cause flowing around the mandrels.
The resulting structure looks generally like that shown in FIG. 12. The tubes 30, 32 are supported where they meet the connection piece and the internal surfaces are smooth since they were formed around the mandrels 114, 116 which of course are withdrawn after the procedure is completed.
The procedure described with reference to FIGS. 8 to 12 can be varied by using different sleeve arrangements and even by building up several sleeves one over another to provide more material flowing and to enhance the strength of the structure.
Turning now to the balloon, after manufacture as described the reference to FIG. 7, the ends are trimmed, and it is positioned on the main body and secured in place using a suitable adhesive. If preferred, the balloon can be bonded to the main body.
FIG. 13 illustrates diagrammatically the balloon in position on the main body 22. For simplicity the wrinkles that will inevitably appear in the balloon are omitted and an imaginary line 130 is drawn on the balloon in a spiral to indicate that the balloon has been attached in this fashion. In other words, the proximal end of the balloon 48 was attached to the main body 22, the balloon twisted about the axis of the body 22 and then the distal end 46 attached so that the balloon has a spiral twist in it. As mentioned previously, there is a molecular orientation which will be along lines such as line 130. The balloon therefore will have a tendency on inflation to take up its normal shape as manufactured in the process described with reference to FIG. 7. Consequently, after inflation the balloon will take on the position shown in FIG. 14 where the line 130 has become axial. In order to accommodate this, the portion of the main body defined between the distal and proximal ends 46, 48 will be subject to a torque indicated by the arrow 132 resulting in this portion of the body receiving an axial twist thereby storing energy in the body. Upon removing the pressure from the balloon 40, the energy stored in the body will return the balloon to the FIG. 3 position (or substantially so) thereby again storing the balloons snugly about the body 22 for removal.
It is of course to be appreciated that angioplasty catheters of the type described are not reused. The energy stored in the body 22 would eventually affect the body if it were used repeatedly but this is not the case in this structure.
In the preferred embodiment the main body has an outside diameter of 5 French (about 0.065 inches) with guide wire lumen about 0.037 inches and fluid supply lumen about 0.017 inches. The portion 56 (which corresponds to the original extrusion) is 7 French (about 0.090 inches), and the lumens 0.039 and 0.024 inches in diameter. The ends of the balloon are twisted relative to one another by about 360 to 540 degrees.
This embodiment and others are within the scope of the invention as defined and claimed.
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Binary options on the GBP/USD: A few approaches
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The question is what might be the best approach to trading the news. Traders could look for signals to trade technical breaks or surprise announcements before and during Governor King's talks. With a binary trade, such as an hourly CALL or PUT option on the pair, the decision boils down to direction and value at risk. For example, in a downtrend you might want to place an $850 hourly PUT option on the pair with a 70% return. If the insurance on the trade were 10% you would have either $1,445 or $85 back from the trade. (Alternatively, the example above shows a current 85% return on the trade, with 0% insurance for out-of-the-money expiration).
If you don't fancy trading on the news, another approach would be to trade on the technicals thru near-term (hourly) support and resistance levels. In this regard a trader might be agnostic to the news on the pound and Governor King's comments, focusing instead on the technical bounce off a support line, or pull back from near-term resistance levels. The hourly window could be a good consideration particularly if impact on longer time frames are less clear.
Last point for consideration for more advanced traders is a hedge on the pair. It could be interesting to set up a binary hedge on the GPB/USD with conventional forex positions, trading for example a bearish FX strategy together with an hourly CALL option to hedge against a potential failed breakout.
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|Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. More recently, 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. 129P3/J is one of the parental substrains.
Former Names 129/J (Changed: 15-DEC-04 ) Type Segregating Inbred; Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a challenging breeder. Species laboratory mouse H2 Haplotype bc (see, Fischer Lindahl K 1997) Generation F198 (05-AUG-14)
Generation Definitions
pink-eyed, light-bellied, light chinchilla
Related Genotype: Aw/Aw Oca2p Tyrc-ch/Oca2p Tyrc
Related Genotype: Aw/Aw Oca2p Tyrc/Oca2p Tyrc
Important Note
This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset prior to three months of age.
Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. (1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently, 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson et al. 1997.
Derivative of strain 101 (L.C. Dunn) when mice from two sublines maintained by Hunt (Tyrc-ch Oca2p / Tyrc-ch Oca2p) and Wynder (Tyrc Oca2p / Tyrc Oca2p) respectively were sent to The Jackson Laboratory in 1948 after the 1947 fire and a cross was made between them. Offspring of the cross gave rise to the Rl, Re, and Rr sublines, the latter giving rise to the 129P3/J substrain, which is maintained as a segregating inbred for Tyrc-ch and Tyrc.
129 Strains
001137 129P1/ReJ 002357 129P3/JEmsJ 001198 129P4/RrRkJ 002448 129S1/SvImJ 009104 129S4/SvJaeJ 012809 129S8/SvEvNimrJ 002064 129T2/SvEms 002065 129T2/SvEmsJ 000691 129X1/SvJView 129 Strains (9 strains)Strains carrying Ahrd allele
000648 AKR/J 008599 B6.Cg-Del(9Cyp1a2-Cyp1a1)1Dwn Ahrd Tg(CYP1A1,CYP1A2)1Dwn/DwnJ 002921 B6.D2N-Ahrd/J 000652 BDP/J 000928 CAST/EiJ 000671 DBA/2J 000674 I/LnJ 000675 LG/J 000676 LP/J 000684 NZB/BlNJ 000726 RBF/DnJ 000682 RF/J 000686 SJL/J 000688 ST/bJ 000689 SWR/J 000693 WC/ReJ KitlSl/J 000933 YBR/EiJView Strains carrying Ahrd (17 strains)Strains carrying Cdh23ahl allele
001137 129P1/ReJ 000691 129X1/SvJ 000646 A/J 000647 A/WySnJ 003070 ALR/LtJ 003072 ALS/LtJ 004502 B6;AKR-Lxl2/GrsrJ 001026 BALB/cByJ 000653 BUB/BnJ 005494 C3.129S1(B6)-Grm1rcw/J 000664 C57BL/6J 004764 C57BL/6J-Cdh23v-8J/J 003129 C57BL/6J-Epha4rb-2J/GrsrJ 004820 C57BL/6J-Kcne12J/J 004703 C57BL/6J-Kcnq2Nmf134/J 004811 C57BL/6J-nmf110/J 004812 C57BL/6J-nmf111/J 004747 C57BL/6J-nmf118/J 004656 C57BL/6J-nmf88/J 004391 C57BL/6J-Chr 13A/J/NaJ 004385 C57BL/6J-Chr 7A/J/NaJ 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 010614 CBACa.B6-Cdh23ahl/Kjn 000657 CE/J 000670 DBA/1J 001140 DBA/1LacJ 000671 DBA/2J 007048 DBA/2J-Gpnmb+/SjJ 002106 KK/HlJ 000675 LG/J 000676 LP/J 000677 MA/MyJ 001976 NOD/ShiLtJ 002050 NOR/LtJ 000679 P/J 002747 SENCARB/PtJ 002335 SKH2/J 003392 STOCK Crb1rd8/JView Strains carrying Cdh23ahl (41 strains)Strains carrying Disc1del allele
001137 129P1/ReJ 001198 129P4/RrRkJ 002448 129S1/SvImJ 002064 129T2/SvEms 002065 129T2/SvEmsJ 000691 129X1/SvJ 002282 BTBR T+ Itpr3tf/J 002243 DDY/JclSidSeyFrkJ 001800 FVB/NJ 000676 LP/J 000686 SJL/J 000689 SWR/JView Strains carrying Disc1del (12 strains)View Strains carrying Polid (2 strains)Strains carrying Rmcfr allele
000765 AKXD13/TyJ 000954 AKXD15/TyJ 001093 AKXD18/TyJ 000947 AKXD22/TyJ 000763 AKXD9/TyJ 000654 CBA/CaJ 000670 DBA/1JView Strains carrying Rmcfr (7 strains)Strains carrying other alleles of Ahr
000645 A/HeJ 000646 A/J 002920 B6(D2N).Spretus-Ahrb-3/J 002831 B6.129-Ahrtm1Bra/J 000130 B6.C-H17c/(HW14)ByJ 000136 B6.C-H34c/(HW22)ByJ 000370 B6.C-H38c/(HW119)ByJ 002727 B6;129-Ahrtm1Bra/J 001026 BALB/cByJ 000653 BUB/BnJ 000659 C3H/HeJ 000663 C57BL/6By 001139 C57BL/6ByJ 000664 C57BL/6J 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000926 CAROLI/EiJ 000656 CBA/J 000657 CE/J 000351 CXB1/ByJ 000352 CXB2/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000356 CXB6/ByJ 000357 CXB7/ByJ 002937 D2.B6-Ahrb-1/J 000673 HRS/J 000677 MA/MyJ 000550 MOLF/EiJ 000679 P/J 000930 PERA/EiJ 000644 SEA/GnJ 000280 SF/CamEiJ 001146 SPRET/EiJ 006203 STOCK Ahrtm3.1Bra/JView Strains carrying other alleles of Ahr (38 strains)Strains carrying other alleles of Cdh23
002552 B6(V)-Cdh23v-2J/J 002756 B6.CAST-Cdh23Ahl+/Kjn 010615 B6.CBACa-Cdh23CBA/CaJ/Kjn 002432 B6J x B6.C-H2-Kbm1/ByJ-Cdh23v-J/J 004764 C57BL/6J-Cdh23v-8J/J 004819 C57BL/6J-Cdh23v-9J/J 005016 CByJ;B6-Cdh23v-10J/J 000275 V/LeJView Strains carrying other alleles of Cdh23 (8 strains)Strains carrying other alleles of Rmcf
000646 A/J 000648 AKR/J 000779 AKXD14/TyJ 000780 AKXD23/TyJ 000764 AKXD27/TyJ 000777 AKXD6/TyJ 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000682 RF/J 000644 SEA/GnJ 000686 SJL/J 000688 ST/bJView Strains carrying other alleles of Rmcf (13 strains)
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Spring 1990; 441. Coat Colors of Sublines of 129 Mice.
New 129 Nomenclature Bulletin
View Phenotypic DataPhenotypic DataMouse Phenome Database
Festing Inbred Strain Characteristics: 129
View Related Disease (OMIM) TermsRelated Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.Deafness, Autosomal Recessive 12; DFNB12 (CDH23)
Schizophrenia 9; SCZD9 (DISC1)
Schizophrenia; SCZD (DISC1)
Usher Syndrome, Type ID; USH1D (CDH23)
View Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Ahrd related
Cancer Research
Increased Tumor Incidence
Gonadal Tumors
Gonadal Tumors: testicular teratomas
Cardiovascular Research
Diet-Induced Atherosclerosis
Relatively Resistant
Neurobiology Research
Angelman syndrome
Hearing Defects
Age related hearing loss
Neurodevelopmental Defects
callosal agenesis, incomplete penetrance
Reproductive Biology Research
Gonadal Tumors
testicular teratomas
Research Tools
General Purpose
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Production of Targeted Mutations (Knockouts)
Sensorineural Research
Hearing Defects
Age related hearing loss
Cdh23ahl related
Research Tools
Toxicology Research
Neurobiology Research
Hearing Defects
Age related hearing loss
Sensorineural Research
Hearing Defects
Age related hearing loss
|Allele Symbol
|Allele Name
|d variant
|Allele Type
|Not Applicable
|Common Name(s)
|Ahd; Ahk; AhRd; Ahhn; ah; in;
|Gene Symbol and Name
|Ahr, aryl-hydrocarbon receptor
|Gene Common Name(s)
|Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity;
|General Note
Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains
|Molecular Note
|This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity. [MGI Ref ID J:15153] [MGI Ref ID J:17460] [MGI Ref ID J:22144]
|Allele Symbol
|Allele Name
|age related hearing loss 1
|Allele Type
|Common Name(s)
|Cdh23753A; mdfw;
|Strain of Origin
|multiple strains
|Gene Symbol and Name
|Cdh23, cadherin 23 (otocadherin)
|Gene Common Name(s)
|4930542A03Rik; CDHR23; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; sals; salsa; v; waltzer;
|Molecular Note
|Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has identified an association between ahl and a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7 and reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ,YBR/Ei, MRL/MpJ. [MGI Ref ID J:86905]
|Allele Symbol
|Allele Name
|Allele Type
|Common Name(s)
|Disc1129S6; Disc1delta6;
|Strain of Origin
|Gene Symbol and Name
|Disc1, disrupted in schizophrenia 1
|Gene Common Name(s)
|C1orf136; SCZD9;
|General Note
|This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T+ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
|Molecular Note
|A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244]
|Allele Symbol
|Allele Name
|polymerase iota deficient
|Allele Type
|Common Name(s)
|Strain of Origin
|Gene Symbol and Name
|Poli, polymerase (DNA directed), iota
|Gene Common Name(s)
|RAD30 (S. cerevisiae) homolog B; RAD30B; RAD3OB; Rad30b;
|Molecular Note
|A nonsense mutation changes codon 27 from serine (TCG) to an amber stop codon (TAG), and results in a truncated protein lacking any catalytic function. The allele was present in every 129 strain analyzed, including 129P3/J, 129X1/SvJ, 129P1/ReJ and 129P2/Ola. C57BL/6J mice did not contain the mutation. [MGI Ref ID J:85061]
|Allele Symbol
|Allele Name
|MCF resistant
|Allele Type
|Strain of Origin
|multiple strains
|Gene Symbol and Name
|Rmcf, resistance to MCF virus
|General Note
This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcfr determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcfs determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1,a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcfr protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxvs/Sxvr mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcfr increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcfr allele contains an endogenous MCF gp70 env gene and that theRmcfs allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.
|Molecular Note
|This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The dominant r (resistance) allele is found in strains DBA/1, DBA/2 and CBA/Ca.
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Genotyping resources and troubleshooting
Festing MF; Simpson EM; Davisson MT; Mobraaten LE. 1999. Revised nomenclature for strain 129 mice. Mamm Genome 10(8):836. [PubMed: 10430671] [MGI Ref ID J:56500]
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Animal Health ReportsRoom Number MP13
Room Number RB06
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a challenging breeder. Diet Information LabDiet® 5K52/5K67
|Pricing for USA, Canada and Mexico shipping destinations
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
|Pricing for International shipping destinations
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
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text:
Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values for Niacin, Biotin and Vitamin B6
Question number: EFSA-Q-2011-01076
Accepted: 7 December 2012Published: 17 December 2012
Accepted: 7 December 2012
This external report is not produced by EFSA. It is published here to help keep the public informed of developments related to EFSA's scientific work. EFSA reserves its rights, view and position as regards the issues addressed and conclusions reached in the present document, without prejudice to the rights of the authors.
Report (7.2 Mb)


text:
|Southern Fiction: The Secret of Magic
Event Type: Book Group
Date: 7/7/2014
Start Time: 7:00 PM
End Time: 8:00 PM
Whether you are from the South and want to go back or if you've always wanted to live there, these books will satisfy that yearning with stories of the history and bravery that many of us wonder if we possess. This month we will read The Secret of Magic by Deborah Johnson. What secrets and lies do these folks of Mississippi have, and will they come to light?Library: Oak Park Public Library Maze Branch
Copies of The Secret of Magic will be available at Maze Branch a month before the discussion. Library book discussions are open to all who are committed to reading and talking about books.
Location: Meeting Room - Maze Branch
Contact: Maze Branch Library
Contact Number: 708.386.4751


text: Table 5-1: Data Sources Used in the 2008 NHQR and NHDR Future Directions for the National Healthcare Quality and Disparities Table 5-1. Data Sources Used in the 2008 NHQR and NHDRFederally Funded National Surveys AHRQ, CAHPS Hospital Survey (HCAHPS) AHRQ, Center for Quality Improvement and Patient Safety (CQUIPS), National CAHPS Benchmarking Database (NCBD) AHRQ, Medical Expenditure Panel Survey (MEPS) CDC, Behavioral Risk Factor Surveillance System (BRFSS) CDC-National Center for Health Statistics (NCHS), National Health Interview Survey (NHIS) CDC-NCHS, National Immunization Survey (NIS) Substance Abuse and Mental Health Services Administration (SAMHSA), National Survey on Drug Use and Health (NSDUH)Health Care Facilities and Clinical Data AHRQ, Healthcare Cost and Utilization Project (HCUP), Nationwide Inpatient Sample (NIS) AHRQ, Healthcare Cost and Utilization Project (HCUP), State Inpatient Database (SID) American Cancer Society (ACS), National Cancer Data Base (NCDB) CDC-NCHS, National Ambulatory Medical Care Survey (NAMCS) CDC-NCHS, National Hospital Ambulatory Medical Care Survey (NHAMCS) CDC-NCHS, National Hospital Discharge Survey (NHDS) CMS, End Stage Renal Disease Clinical Performance Measures Project (ESRD CPMP) CMS, Home Health Outcomes and Assessment Information Set (OASIS) CMS, Medicare Patient Safety Monitoring System (MPSMS) CMS, Nursing Home Minimum Dataset (MDS) CMS, Quality Improvement Organization (QIO) program, Hospital Quality Alliance measures National Institutes of Health (NIH), U.S. Renal Data System (USRDS) SAMHSA, Treatment Episode Datasets (TEDS)Surveillance and Vital Statistics Data CDC, HIV/AIDS Surveillance System CDC, National Program of Cancer Registries (NPCR) CDC, National Tuberculosis Surveillance System (NTBSS) CDC, National Vital Statistics System: Link Birth and Infant Death Data (NVSS-I) CDC, National Vital Statistics System: Mortality Data (NVSS-M) CDC, National Vital Statistics System: Natality (NVSS-N) National Cancer Institute (NCI), Surveillance, Epidemiology, and End Results program (SEER)Other CMS, Medicare Administrative Data (MAD) CMS-National Hospice and Palliative Care Organization (NHPCO), Family Evaluation of Hospice Care Survey (FEHCS) HHS, HIV Research Network (HIV RN) Indian Health Service (IHS), National Patient Information Reporting System (NPIRS) National Committee for Quality Assurance (NCQA), Healthcare Effectiveness Data and Information Set (HEDIS) NIH-National Institute of Mental Health (NIMH), Collaborative Psychiatric Epidemiology Surveys (CPES) University of Michigan, Kidney Epidemiology and Cost CenterSources: AHRQ, 2009a, b.Return to Document Page last reviewed October 2014 Internet Citation: Table 5-1: Data Sources Used in the 2008 NHQR and NHDR: Future Directions for the National Healthcare Quality and Disparities . October 2014. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/research/findings/final-reports/iomqrdrreport/futureqrdrtab5-1.html