text:
Sellers donates forestry papers
A retired Mississippi State University professor recently donated his professional archives to the Forest History Society Library in Durham, N.C.
Forest products professor emeritus Terry Sellers Jr. was invited to donate his collection of research, publications, patents and speeches to the nonprofit educational institution associated with Duke University.
Cheryl Oakes, the Forest History Society librarian, said the papers help fulfill the library's mission, which is to document all aspects of forests around the world and their significance to people.
"As a scientist, Dr. Sellers has spent his career in an aspect of the forest products industry that is unique and that gives us a firsthand look at changing technology and the role of research," Oakes said. "His work complements that of other people whose papers have found a home at the Forest History Society."
A Sharp Professor of Forest Products, Sellers worked at MSU as a researcher and educator for 24 years before retiring in 2004. He studied natural and synthetic adhesives and engineered wood products, such as particleboard, plywood and laminated beams and arches.
Sellers' book, Plywood and Adhesive Technology, has received worldwide praise. Many of his publications have been translated into Japanese and Spanish. He has worked as a private consultant for academic, governmental and industry clients in 16 countries.
During his tenure at MSU, he received a patent on his work with kenaf, a fibrous plant similar to bamboo.
Sellers is the past president of the International Forest Products Society and has been honored by the U.S. Department of Commerce for international standards work. He has also received accolades from Shell Oil Co. for adhesive research and the Forest Products Society for outstanding service to the profession. In 2006, Sellers was named Outstanding Alumnus in Auburn University's College of Forestry and Wildlife Sciences.
The Forest History Society was founded in 1946 and works to preserve forest heritage by collecting and preserving information on the relationships between forests and the people around them.
"It is gratifying for the Forest History Society to request my papers, which represent my 20 years in industry and 24 years in academia," Sellers said. "I hope that this collection will expand the history of forest products composite research in their collection."
Dave Storment | MSU Ag Communications


text:
Guides you through the process of script writing for informational videos, commercials, and public service announcements.
Covers some simple and inexpensive lighting techniques to make everyone look their best on camera.
The second installment in the On Camera series, which concentrates on enhancing your appearance on-screen with the right amount of makeup.
Discover how to conduct yourself on camera and make a positive impression in front of the lens.
Shows how to set up an effective Soundtrack Pro system and establish a fundamental workflow, from simple audio processing to final mixdown and exporting.
"Your presenters are superb. They work well with the camera, they are eloquent, speak well, and establish a collegial rapport with the learner." —Brian C.
more from our members »

subset: commoncrawl


text:
Posted 5 years ago
(10 items)
20''in x 34''in Oil on Canvas 'West by South' signed by listed Maine/New York artist Leo John Meisner.
(Ocean Scene)
19.5''in x 33.5''in Oil on Prest Wood 'Low Lands Melody' signed by listed Maine/New York artist Leo John Meisner.
(Cat Nine Tails)
'West by South' was a beautiful, good sized oil painting of an ocean scene that was a highlight of our July 24th Fine Estates & Collectibles auction. Personally, we liked 'Low Lands Melody' depicting the cat nine tails the best, but an auction crowd knows what they want and 'West by South' was the one to fight over.
'West by South' Hammer Price: $400.00 USD
'Low Lands Melody' Hammer Price: $250.00 USD


text:
Register now for free, or sign in with any of these services:
My vote will be an absolute NO!!! I am tired of the dems attempt to solve problems with more money- that being OUR MONEY. Not going to happen pupper Shiela
TOPSECRET: Its is not illegal to have check points- but there are some guildlines they are suppose to use- ie stop every 5th car, or every blue car,etc. however they can pull over for other reasons as well as they normally would on patrol- head light out, etc. So- you are incorrect !!
FINALLY the NJ Supreme Court got it right!!!
They need to bull doze this Mansfield Village down and start over. Does this Landlord have ANY screen process- place is full of Warren Countys trash time to clean up
JC Girl yes we have movie theaters out here- we even have running water.
I believe that in part what is going on is that the kids are seeing the media work overtime to sensationalize the Clementi story and as kids they see suicide as a way out- they are not mature enough to REALLY realize that its the end- you do not come back. Really very sad
Thank you Martha- me sentiments exactly!!!! Its pretty simple
I was initially going to comment on how interesting the timeing was that Lautenberg comes out of the woodwork to help our Vets that being election time for his boy but I wont- instead I am here to express tremendous thanks for helping our Vets
WITHIN 6 HOURS of each other !!
amazing- two reporters writting about the same story three times
pitlord- you must be one of 12 workers I saw the other day that were making a repair to a man hole . One guy in the hole doing the actual work, two flagmen and the rest standing around. Now THATS effeiciency NJ State workers union style!!! . THAT practice is the next area CC should be looking into and cutting- its been a joke forever but in all seriousness- i needs to be dealt with
Rockaway Police- get off your chairs and get out from behind the wheel of your cars and do some 'real' police work. You people are a joke and now you criticize small business men?
soon the USA wil be renamed Little India. Just saying
. State Sen. Barbara Buono (D-Middlesex), who is considering running against the governor next year, warned on the social networking website Twitter that "parents should (be) alert (to) unpredictable outbursts of anger." tHEY SHOULD ALSO BE ON THE ALERT TO UNPREDICTABLE OURBURSTS OF STUPIDITY from people like Sen. Buono
Holy Sh*&-- toughen up your skin whinners and get the hell over it already!!!!
Jenna Portnoy- STAY ON TOPIC !!! The article you wrote has zero to do with his comments to your fellow reporter.
He's not an embarassment at all- I am damn proud !
60% approval rating does not indicated majority of us are tired of this Governor.
60% approval rating does not indicated majority of us are tired of this Governor.


text:
The Antlers Bearcats and Lady Cats celebrated their Basketball Homecoming on Friday, January 21, 2011 at the Bearcat Gym. The 2010-2011 Antlers Basketball Homecoming King and Queen were named as # 22 for the Bearcats- Kayl Bryant and #13 for the Lady Cats - Jade O'Donnell. Â
The Rattan Lady Rams competed in a MC-6 Tournament and brought home the John Rind MC-6 Tournament Girls Championship for the first time.  Lady Rams Lyndi Noel's field goal in the last seconds of the game proved to be exactly what the Lady Rams needed to beat out the Valiant Lady Dawgs with a 34-32 win.
Coach Gibbs said that Login and Lyndi Noel both turned in a good game and despite a low shooting percentage for the Lady Rams in the first half, Lindsay Winship and Hayley Deaton provided just enough offense to keen the top seed close to last year's tourney champion.
James "Cubby" Hayden Owens was born February 20, 1939 in Bentley to Berry Bud and Chrystal "Crick" Neomi (Martin) Owens. He passed from this life March 17, 2011 in Centerpoint at the age of 72. James, often called Cubby, married Dee Daniels on August 22, 1960 in Madill. He was a lifetime cowboy who enjoyed the outdoors, bird and coon hunting and playing dominoes. He loved his horses and dogs and spending time with his family and friends. James was preceded in death by his daughter: Della Marie Owens; and parents: Crick and Bud Owens.
Reverend Larry Keith Lewis was born October 15, 1951 in Hayward, CA, to Alvis and Rachel (Wisener) Lewis. He passed from this life March 14, 2011 in Hugo at the age of 59. Larry Keith Lewis married Rita LaGene Knight August 11, 1970 in Empire, CA, and together they raised two children. Reverend Lewis pastored churches in Nevada, California and Oklahoma. He had been a minister since the age of 17. He was a tax preparer for H&R Block in Muskogee for many years, and was an auctioneer since 1990. Larry was recently retired and living in Rattan.
James Lewis Lamar, 74, of Jumbo passed from this life on March 20, 2011 at the Paris Regional Medical Center in Paris, TX. He was born on January 11, 1937 to the late Curtis Lamar and Jonnie Crook Lamar in Woodville. James married Priscilla Henderson on July 17, 1958 in Hugo. James served in the United States Navy for 20 years before retiring as a chief. He then earned his bachelor degree and taught school in Beeville, TX. He was a member of the First Baptist Church in Antlers where he served as deacon for several years. James enjoyed crafting woodwork out of cedar.
Laura Ellen Davis was born November 1, 1928 near Bethel in one of the early moving towns in Eastern OK, to Calvert M. and Gertie E. (Mouser) Smith. She passed from this life on Friday, March 18, 2011 in Hugo at the age of 82. Laura married Grobin Davis on May 10, 1947, in Fort Smith, AR. They were residents of Oklahoma for the past thirty years. Laura worked as a post office clerk in Wright City and different offices for 20 years; she retired as postmistress of the Rattan Post Office after 3 years.
Harlan Eugene Boyett was born October 20, 1935 in Glendale, AZ, to Odis and Eva (Barrow) Boyett. He passed from this life March 13, 2011 in Tulsa at the age of 75. Harlan married Dolores Terry on November 4, 1961 in Carson City, NV, and together they raised three children. He enjoyed "helping" the grandkids pick up rocks and prickly pears out of the yard and watching Gun Smoke. Harlan especially loved playing with his grandkids and spending time with his family and friends at Arpealer's.
Monday, March 21, 2011 the Antlers Board of Adjustments held a public hearing at the Antlers City Hall at 5:00 p.m. This meeting was to hear a request from Pine Telephone Co., Inc., out of Broken Bow, who were asking for a special exception from Antlers City Codes to allow a cellular antenna tower, of less than 200 feet, to be constructed in a commercial business district at 412 S.W. "C" Street in Antlers.
The Girl Scouts are facing bullying head on as they use their "Powered Up: Doing Nothing? Not an Option!" program in local schools. This 8 week program started in the Antlers Intermediate School (Vegher) on February 28th and has been held every Monday from 2:15-3:00 p.m. (except for spring break week).
Kealey Standridge, student at Antlers High School, has officially won the District Essay competition for the VFW's "Voice of Democracy" Essay contest, for the 3rd year in a row. This essay contest is an annual contest which the VFW (Veterans of Foreign War) puts on as a scholarship program.
"We are as proud of this girl as we can be," said Mr. Neil Kimberland, member of the VFW. "It is students like her who help us have big hopes for the future."


text:
A method for screening newborns using electrospray tandem mass spectrometry. The method improves the current protocols that use tandem mass spectrometry by assuring accurate and consistent results at the clinical level through enhanced quality controls and quality assurance protocols as applied to the scan profiling and sample preparation of blood spots from newborns. Specific additives are used in precise concentrations of internal standards, employing detailed controls adapted to distinguish twenty metabolites, which are scanned and vigorously compared to known spectra results. Revealing peaks, metabolite concentration, and scan intensities in the quality assurance steps are then compared to a range of thresholds to determine whether or not the sample is contaminated, drug-ridden, diagnosable, or unacceptable. All spectra results and quality assurance flags are organized in spreadsheet form and exported to a database where values are compiled and stored for daily output results and trend analysis. The method provides for high-throughput and quality results, having a consistent predictability for genetically testing newborns efficiently and accurately.
1. An internal standard preparation comprising 2H9-carnitine, 2H3-acetylcarnitine, 2H3-propionylcarnitine, 2H3-butyrylcarnitine, 2H9-isovalerylcarnitine, 2H3-octanoylcarnitine, 2H9-myristoylcarnitine, and 2H3-palmitoylcarnitine.
2. The internal standard preparation of
3. The internal standard preparation of
4. The internal standard preparation of
5. The internal standard preparation of
6. The internal standard preparation of
7. The internal standard preparation of
8. The internal standard preparation of
9. The internal standard preparation of
10. The internal standard preparation of
11. The internal standard preparation of
12. The internal standard preparation of
13. A composition that includes the internal standard preparation of
This application is a continuation-in-part of U.S. Ser. No. 10/252,115 filed on Sep. 23, 2002 now U.S. Pat. No. 7,011,977, which is a continuation-in-part of U.S. Ser. No. 09/464,132 filed on Dec. 16, 1999, now U.S. Pat. No. 6,455,321, which is a continuation-in-part of U.S. Ser. No. 09/277,119 filed Mar. 26, 1999, now U.S. Pat. No. 6,258,605, which claims the benefit of provisional application U.S. Ser. No. 60/117,880 filed on Jan. 30, 1999. The disclosures of each of these cases is incorporated herein by reference in their entirety.
1. Field of the Invention
The present invention relates to a high throughput, cost-effective, and low false-positive method of genetic screening, capable of performance over a wide range of metabolite groups, using electrospray tandem mass spectrometry. Efficient sample preparation and stringent quality controls are implemented as critical keys in maintaining consistency and accuracy in the resulting data for use in medical diagnosis.
2. Description of Prior Art
Mass spectrometry has been making significant contributions to the diagnosis of metabolic diseases for over 20 years. Fast Atom Bombardment Tandem Mass Spectrometry (FAB-MS/MS) analysis of acylcarnitines in very small volumes of whole blood or plasma has been previously made routine. See Millington, et al., Mass Spectrometry: Clinical and Biomedical Applications, 1, ch. 8, 299-318. It had been a very satisfactory biochemical method for the differential diagnosis of disorders of fatty acid catabolism, and the instrumental method recognized numerous defects of branched-chain amino acid catabolism. The frequency of occurrence of these diseases and their association with sudden, unexplained deaths has generated a great medical interest in the development of neonatal screening tests.
Routine analysis of amino acids and acylcarnitines by Liquid Secondary Ion Tandem Mass Spectrometry (LSIMS/MS) from blood spots on filter paper has been demonstrated previously as well. See Chace et al., "Neonatal Screening for Inborn Errors of Metabolism by Automated Dynamic Liquid Sewary Ion Tandem Mass Spectrometry New Horizons in Neonatal Screening, 1994. To increase the number and rate at which samples can be analyzed, the development of automated sample preparation, instrumental analysis, and data interpretation was required. The increase in sample throughput and the ease of sample preparation allows for the more efficient and exacting diagnosis of a great number of metabolic disorders, a process necessary in determining the health of a newborn baby, or, for that matter, anyone in clinical care. The ranges of clinical symptoms and abnormalities in simple blood tests are so extreme that extensive biochemical investigation is warranted whenever metabolic disease is suspected, as noted in Millington, et al., "Diagnosis of Metabolic Disease," from Biological Mass Spectrometry: Present and Future, 3.15, 1994.
Metabolic profiling of amino acids and acylcarnitines from blood spots by use of automated electrospray tandem mass spectrometry (ESI-MS/MS), is a more powerful diagnostic tool for inborn errors of metabolism. See Rashed, et al., Clinical Chem. 43:7, 1129-1141. New approaches to sample preparation and data interpretation have helped establish the methodology as a robust, high-throughput neonatal screening method. Compared with older methods, ESI-MS/MS is much more versatile and less labor intensive, because most of the steps can be automated.
Inborn errors of metabolism usually result from defective enzymes or cofactors. Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is a very common disorder of fatty acid oxidation. As seen in Chace et al., Clin. Chem., 43:11, 2106-2113, MCAD deficiency is diagnosed on the basis of the increase of medium chain length acylcarnitines, as identifiable by isotope dilution mass spectrometry methods. Butyl esters of acylcarnitines share a similar fragmentation pattern with a common fragment ion at 85 Da after collision-induced dissociation using a mass spectrometer. The fragmentation pattern differences are compared to known spectra of healthy individuals and thereby can be diagnosed. In a clinical setting, analysis of acylcarnitines by tandem mass spectrometry is possible as their associated methyl esters allow the diagnostic recognition of all patients with MCAD deficiency, regardless of the underlying mutation, symptomatic state, or treatment Also, the analysis of amino acids as their associated butyl esters has been validated for newborn screening of phenylketonuria (PKU), tyrosinemia, maple syrup urine disease, and homocystinuria, all of which, among others, are detected by mass spectrometry.
The most selective and sensitive spectrometry, as it relates to genetic disorders, is performed by the automated, electrospray tandem mass spectrometer. The use of ESI-MS/MS has been presented to successfully and quickly provide a specific and accurate screening method (Rashed, et al.). The method itself, however, must be complemented with an efficient sampling procedure and optimized injection and scan function mode to accommodate, with utmost accuracy, many samples at one time, thereby maximizing throughput while maintaining sensitivity and accuracy.
The efficiency of the ionization of the compounds is very high with the implementation of electrospray ionization. As seen in U.S. Pat. No. 5,352,891, Monning et al., the high ionization efficiency allows useful spectra required for even very small quantities of material. In other words, electrospray tandem mass spectrometry is very sensitive and specific in regards to its compound injection systems, thereby allowing a more broad spectrum of diseases to be covered, a lower false positive rate to be achieved, high specificity to be obtained, and shortened analytical time permitted. The use of the electrospray tandem MS/MS has been shown to increase throughput. Moreover, the technique has been successfully applied to prenatal diagnosis (Rashed, et al., 1130) and other screening processes. However, optimization of the method of screening newborns must be achieved by maximizing sample throughput in the most efficient and accurate way, beginning in the sample preparation, and culminating with the quality assurance. The overall process lends itself to parental peace-of-mind, and expedient and cost-effective results.
Sample preparation in support of the genetic screening of an individual for carnitines and .alpha.-amino acids (genetic markers for inborn errors in metabolism) for use in mass spectrometry is seen in the art. The standard method of collecting samples for neonatal screening is a heel prick followed by depositing the whole blood on special filter paper (or Guthrie cards) as a series of spots. See Millington, et al., International Journal of Mass Spectrometry and Ion Processes, 111, 212, 1991. The latest developed method of preparing the butyl ester derivatives of acylcarnitines and amino acids from the blood spots consists of processing samples in microplates. An automated blood-spot puncher punches a single blood spot from each Guthrie card directly into the individual wells of the microplate. To the blood spot punch in each well a methanolic solution containing known concentrations of stable isotope-labeled standards is added. The label standards might include glycine and alanine; valine, methionine, and phenylalanine; leucine and tyrosine; ornithine; carnitine; acetylcarnitine; propionylcarnitine; octanoylcarnitine; and palmitoylcarnitine, all in combination in some concentration as to enhance the sensitivity for particular compounds, as required by respective testing protocol. The samples are extracted and the extracts are then transferred to another microplate where the methanol is removed through evaporation. To the residue in each well, butanolic HCl or other chemical modifiers are added and the derivatization is completed by heating. Final residues are reconstituted and placed in an autosampler tray for introduction into the MS.
The incorporation of isotope-dilution techniques as standards provides quantitative information for specific components of each sample. There is the need for an optimal concentration of a combination of 12 amino acid standards and 8 acylcarnitinelcarnitine standards to improve accuracy and provide for quality control, as well as to provide for a number of scan functions that maximize metabolite information with high-throughput. Quality control and quality assurance in a clinical environment is of utmost importance because of the method and instrumentation that has evolved for the optimization of sample throughput. It is especially important as mass spectrometry results are correlated to the general populations of newborns so as to show accurate results in demographic trends.
The advantages of ESI-MS/MS over alternative methods of analysis are its high specificity and accuracy of quantification through use of the isotope-dilution technique, plus its speed and amenability to automation See Chace et al., Clin. Chem. Vol. 39, No. 1, 1993. Coupling the sensitivity in detection with the requirement that newborn screening requires rapid throughput, high accuracy, high precision, high selectivity, and a high value to low cost ratio, there is now a need in the clinical environment, now satisfied by the present invention, for an accurate means of assuring the quality of data for genetic disorder diagnosis is obtained in an organized and accurate manner. This quality can be coupled to the most efficient method of preparing and scanning samples, so as the number of false-positives and false-negatives are reduced, and sample throughput is necessarily maximized in the diagnostic clinical setting.
U.S. Pat. No. 5,538,897, Jul. 23, 1996 (Yates, III et al.) shows a method for correlating a peptide fragment mass spectrum with amino acid sequences derived from a database. A peptide is analyzed by a tandem mass spectrometer to yield a peptide fragment mass spectrum. A protein sequence database or a nucleotide sequence database is used to predict one or more fragment spectra for comparison with the experimentally derived fragment spectrum. The various predicted mass spectra are compared to the experimentally derived fragment spectrum using a closeness-of-fit measure, preferably calculated with a two-step process, including a calculation of a preliminary score and, for the highest-scoring predicted spectra, calculation of a correlation function.
U.S. Pat. No. 5,206,508 Apr. 27, 1993 (Alderdice et al.) teaches a tandem mass spectrometry system, capable of obtaining tandem mass spectra for each parent ion without separation of parent ions of differing mass from each other. This system would in addition provide the capability to select a particular ion prior to excitation.
U.S. Pat. No. 5,352,891, Oct. 4, 1994 (Monning et al.) demonstrates the production of mass spectra of chemical compounds of high molecular weights having a multiplicity of peaks is improved by generating an enhanced mass spectrum from the observed mass-to-charge spectrum. Signal-to noise ratio can in some applications be improved by including in the product all portions within the discrete peaks in the mass-to-charge spectrum, which are contained within a window around each of the discrete peaks.
It is the objective of the present invention to improve the method of screening newborns by implementing efficient sampling protocols and data quality controls. As initial and final steps to the use of electrospray tandem mass spectrometry for inborn metabolite error screening, the sample efficiency and quality assurance will complement a more rapid sample throughput method with a high value to low cost ratio. All values are compared to known thresholds as a means for evaluating the contents of the sample. High accuracy and high precision found in a large number of samples will quickly provide consistent diagnosis at the clinical level.
Electrospray tandem mass spectrometry is very sensitive and specific and can detect a broad spectrum of disorders at the genetic level. The already shortened analytical time and high specificity increases the rate at which samples that can be analyzed. Including internal standards in the sample preparation that decrease extraction error and allow for mixed mode scan functions further increases sample throughput The internal standards are used to provide the quantitative information needed to detect specific components. Use of proper ratios of each particular ion enables the detection of many metabolites at one time, thereby eliminating duplicate analysis, allowing secondary runs to be used for quality assurance and proficiency testing rather than for detection of preliminary compounds.
It is a secondary objective of the present method to include EDTA standards that can determine whether or not the blood was collected properly. Contaminated blood or blood collected from tubes rather than a heel prick spot is improper and identifiable by this standard.
It is a third objective of the present method to include quality assurance standards such as 2H3-Serine (deuterium 3 labeled Serine) to show the computer is recognizing normally unfounded compounds. Serine is an amino acid that is not included or recognized in a normal scan, so 2H3-Serine is added to an acylcarnitine scan to show that, when this compound is detected and shown as a peak, the computer is capable of detecting foreign compounds. In effect, drug-ridden or contaminated samples may be flagged.
It is a fourth objective of the present method to include proper correction factors, mass values, quality assurance flags, and sample preparation flags as input values, complementing a database that is used for checking calculations as produced using a spreadsheet, thereby insuring accurate data reduction. This provides enhanced quality assurance. When an abnormal sample is noted, a recommended action is to be taken. Database storage of values facilitates disease rate data reporting, trend generation and analysis, total sample-per-day values, and QA/QC analyses.
It is a fifth objective of the present method to include a quality control step that uses unlabeled standards and control blood standards to assure the consistency and accuracy in the detection of the twenty metabolites.
Accordingly, the method generally comprises, after receiving a plurality of blood spots, combining an amino acid standard and a free carnitine/acylcarnitine standard to form an internal standard containing a plurality of labeled compounds. A plurality of samples are prepared wherein each of said samples comprise the internal standard, methanol, and a blood extract from one of the blood spots taken from the newborn baby. The samples are scanned using the electrospray tandem mass spectrometer to produce scan results. Control blood samples are then prepared and scanned, wherein each of said control blood contain hemolyzed blood, EDTA, 2H3-Serine. A plurality of standards having hemolyzed blood, EDTA, 2H3-Serine, and one of the labeled compounds is also prepared and scanned. Ultimately, the control sample results obtained for each of the quality control samples is compared to the plurality of standard results obtained for each of said standards. In this way, the data obtained for each newborn scan result is assured accuracy and consistency for any further action such as diagnosis or re-testing.
The method will now be described in detail in relation to a preferred embodiment and implementation thereof which is exemplary in nature and descriptively specific as disclosed. As is customary, it will be understood that no limitation of the scope of the invention is thereby intended The invention encompasses such alterations and further modifications in the illustrated device, and such further applications of the principles of the invention illustrated herein, as would normally occur to persons skilled in the art to which the invention relates.
The methanol serves as the solvent extraction medium while the internal standards serve to quantify the metabolites in the dry blood matrix The internal standard preparations 22 comprise an ideal mix of twenty stable isotopes—twelve amino acid standards and eight acylcarnitine/carnitine standards. A list of the amino acid standards can be found in
Free Carnitine and Acylcarnitine internal standards are listed in
Both groups of standards are provided in the extraction medium for the optimum mixed mode scan functions, which maximize metabolite detection. The metabolite groups detected include the .alpha.-amino acids—alanine, phenylalanine, tyrosine, glutamic acid, ornithine, citrulline, arginine—and the carnitines—free carnitine, acylcarnitines, acetylcarnitine, octanoylcarnitine, palmitoylcarnitine.
Now following
Examples of the values of the thresholds can be seen in
A profile of the Acylcarnitine full scan is shown in
Another QA method is used in this scan, revealed by an intensity value 618. An elevated intensity value shows the sample was scanned with adequate sensitivity. If the intensity value 618 is too low, the sample will be flagged (noted), and the sample may be re-tested depending on the protocol.
Citations de brevets
Citations hors brevets
╔vķnements juridiques
Image d'origine
Faire pivoter


text:
Year of Faith
Pope Benedict XVI declared that a "Year of Faith" will begin on October 11, 2012 and conclude on November 24, 2013. October 11, 2012, the first day of the Year of Faith, is the fiftieth anniversary of the opening of the Second Vatican Council. In celebration of the Year of Faith, St. Anne's will be presenting a variety of scripture study opportunities and activities.
Sunday Morning Adult Religious Education
A 12 week study of the Creed as part of an ongoing study of Catechism (Pillars of Faith). Sunday Morning Adult Religious Education Class meets most Sundays in the greatroom from 9:45am - 11:00am. Everyone is welcome to attend. No need to sign-up, just come when you can. For a complete schedule please click here.
"Year of Faith" Scripture Study
The Year of Faith scripture study begins the week of October 1, 2012. Sign ups begin mid-September. Watch the bulletin for more details. Study groups will meet as follows: Monday 1:00pm - 2:30pm and Tuesday 6:15pm - 7:45pm
Evangelization Team Project
St. Anne's Evangelization Team will be organizing a project to reach out to Catholics in our community that are loosely connected to the church. In an attempt to reestablish a new, stronger unity with these parishioners, a book, "Rediscovering Catholicism" by Matthew Kelly will be sent to them. This will hopefully prompt a desire to return to attending Mass on a regular basis.
Parish Family Nights and the Year of Faith
This year, in conjunction with the Year of Faith, which begins on October 11, 2012, the fiftieth anniversary of the opening of the Second Vatican Council, Parish Family Nights will be focusing on the changes brought about by the introduction of Vatican II. For a complete list of topics and more information please click here.


text:
Cult Nails Awakening Nail Lacquer
Cult Nails Hypnotic Collection Review, Photos, Swatches
Cult Nails Hypnotic Collection is now available, and Temptalia readers can take $5 off $40+ orders with code TEMPTALIA, good through 8/31. There are four shades in the fall collection, and each bottle contains 0.5 fl. oz. and costs $10. The shades include: Awakening (dusty teal), Enigmatic (purple base with a brown hue), Hypnotize Me (sheer green jelly with glitter), and In a Trance (olive green to muted gold).
- Awakening is a dark, smoked teal-blue with a cream finish. I needed three coats for opaque color, because the consistency is on the thinner side. It has a dustier appearance (so it looks more muted, less intense) compared to MAC Deep Sea and Rescue Beauty Lounge Teal. It's like a teal version of MAC Blue India.
- Enigmatic is a plum purple with hints of brown and red flecked with silver and plum shimmer. I needed two coats for opaque color. The brown hues of the shade disappear under brighter light. China Glaze Urban Night is a bit lighter and doesn't have any shimmer.
- Hypnotize Me is a very barely green-tinted base with iridescent blue and green glitter. It's supposed to be sheer, and if you want a more cohesive result, it's probably best as a layering shade. The texture is extremely thick–it's very much like jelly or jam or even like hair gel (thick of the type in a tub). Because of the overall thickness of the formula, you have to be careful applying the color. I only did two coats, because I didn't want to go too thick.
- In a Trance is a olive green with tarnished gold shimmer. It was opaque in two coats, and the formula was just right–not too thick or too thin. To me, this was the standout shade of the four, particularly because of how easy it was to apply. The base color is similar to Rescue Beauty Lounge No More War. It's not quite as bright or as green as China Glaze Peace on Earth.
In a Trance had the best formula, while Awakening was a little sheer (needed three coats) and Hypnotize Me is extremely thick (not gloppy necessarily, but it truly has the texture of a gel). I like the concept of Hypnotize Me but would appreciate a thinner consistency overall. In the past, I've tested out several shades from Cult Nails, and the wear is great–a good week with minor tip wear (with a proper base/top coat).
The Glossover
Cult Nails Hypnotic Collection Review, Photos, Swatches
|In a Trance is lovely, and it's definitely better than a B-, but shades like Awakening and Hypnotize Me brought down the overall score.
|Login or Register to be able to add this to your Vanity or Wishlist! Plus rate and review!


text:
Love just got a little less tough for one of the ladies…
Picking right back up from last week's superlatives…
Most Likely To Be Used as a Sex Toy, Take 3 -This…
…actual sex toy!
And it's a treasured sex toy, at that.
Most Likely To Appear On Rock of Love 4 (Redux) – Arian
And she's got the "rock hand" to prove it!
Most Likely To Wear Dental Floss as Outerwear - Arian
Probably goes without saying after the last item, but you know, nothing wrong with being thorough.
Most Likely To Show Remorse for Having a Sexual Side – Arian
Just kidding! She's just playing coy!
There, that's more like it.
Most Likely To Wear a Turtleneck in Playboy - Jody
Not that we hold her wish to keep her dignity against her. It's just that this is VH1 so it seems…weird.
Most Likely To Get Crumbs in Bed – Abiola
"I'm a girl who eats, and that is sexy," she said on her philosophy behind posing with cupcakes. So many women have such negative relationships with food that I'm gonna put the scoffing and bizarreness-dissection on the back burner, and just say: go on, girl!
Most Likely To Rock Björk's Swan Dress – Stasha
For the record, she's also the most likely to wrestle a live swan into submission, sling it around herself and rock that. Ah, fresh couture. She's "very, very artistic" like that.
Most Likely To Have a Secret S&M Basement - Natasha
It's like someone pushed a lever and got right to her secret passageway.
Least Likely To Guest as Judges on America's Next Top Model – These guys:
They not only praised Natasha's open-mouthed, fly-catching shot, they ragged on Jody for looking, grumpy. Uh, guys? Some of us would call that "fierce." Most of us who did so probably aren't into women, but whatever! Seriously, Stasha is a "transsexual Selena?" Sounds fierce to me!
Least Likely To Own a Dictionary - Taylor
"If you open up a dictionary and read down and find sexy, it says, 'Taylor, definition of sexy,'" reports Taylor. That's not really how dictionaries work. I don't think she's a reputable source.
Most Likely To Have Stolen Taylor's Dictionary - Shelton
Here is where the self-assured congregate. It's a meeting of the minds bodies.
Most Can-You-Believe-This-TV-S***? Moment –
Terrence wonders, "Who sleeps in pajamas?" Abiola concurs, explaining that she sleeps nude. With any luck, this is yet another meeting of the bodies.
Most Likely To Be Drinking the Kool-Aid by Osmosis – Arian
She resists Steve's methods, and yet, here she is preaching them to her date when he brings up the subject of exes. "You're not supposed to talk about past relationships! It's in the book!" she hit back. That this led to them both agreeing that ditching the rules and making out was a much better idea is neither here nor there.
Least Likely To Stab Someone in the Back – Taylor
She goes right for the heart, instead! Here she openly disses Sheldon's ambitions and bank account. Hey, at least she's honest!
Least Likely To Become a Professional Tumbler - Taylor
Although if she did, she'd be the most entertaining professional tumbler ever!
Least Likely To Resist Her Maternal Instinct – Jody
Even though she talked about not liking Taylor (with good reason, since Taylor called her "ugly") and had open concern about Taylor's return to the house, Jody stepped in to help stop Taylor for making more of a drunken fool of herself. And good TV. Damn it, mom, you never let us have any fun!
But oh well, at least Jody ended up getting a character boost.
Most Improved – Jody
And boosting and boosting! You don't get a second chance to make a first impression, so the fact that Jody was able to win over the guy she had a pretty lousy date with last episode is further testament to her achievement.
Most Likely To Pattern a Relationship Like a George Michael Video – Jacklyn
"He's gonna be like the perfect father figure," said Jacklyn on her family-oriented suitor.
No word yet on how he'll fare as a preacher-teacher, though.
Most Likely To Tell Boldfaced Lies - Taylor
When confronted about her behavior during the lingerie party, Taylor said that her lack of interest in Sheldon had to do with his career path being too similar to hers. "It was never about the money," she claimed before being presented with video evidence stating the otherwise. But thank god this happened because it led to Taylor breaking down and revealing an actual reason behind the gold-digging:
She had to give her 16-month-old child up for adoption for lack of funds. Her over-the-top behavior has roots in real, live hardship, and realizing this made empathazing with her so much more possible. Way to go, Taylor.
Related content
VH1 Tough Love show page
VH1 Tough Love videos and extras
Master Matchmakers


text:
LAS CRUCES, N.M. -The 2012 New Mexico State Football team held practices No. 12 and 13 on Wednesday, marking the team's second two-a-day session of this week with another scheduled for Friday. The Aggies practiced for about two hours in each practice.
After being challenged the day before by head coach DeWayne Walker, the team stepped up its focus and execution in the morning practice. The Aggies also went through their daily progression of position and special teams drills.
In the second practice the team continued conditioning and position drills in full pads. The defense earned praise from Walker in the second scrimmage session of the day as the offense began to pick it up late.
The Aggies will be back on the field for a single practice, No. 14, tomorrow from 3-5 p.m.


text:
James MarshName: James Marsh
Locaton: Bradenton
Date of Death: February 5, 2014
Age at death: 82
James "Jim" Curtis Marsh, Sr., 82, Bradenton, passed away Feb. 5, 2014. Jim was born Jan. 10, 1932 in Huntsville, TX to the late Otto Curtis & Dorothy (Thompkins) Marsh. He was a graduate of the Lamar State College of Technology in Beaumont, TX, and moved to Bradenton in 1966 coming from Lufkin, TX. He worked as a mechanical engineer for Miller Trailers and Logan Steel in Bradenton, and also was the owner and operator of Ambit Fabricating in Bradenton. Jim was also an avid bowler and master of all things mechanical. He is survived by his three loving children; Judy Carol Bowen of Kannapolis, NC, James "Jim" C. Marsh, Jr. of St. Petersburg, FL, JoAnn "Josie" (Charlie) Conoley of Bradenton, sister, Dorothy Ann (Ken) Cheairs of Dallas, TX, five grandchildren, two great-grandchildren, two nephews and many extended family members and friends.
Funeral Information:
Private family services will be held at a later date. The family requests in lieu of flowers that memorials be made to the Wounded Warriors Project in his memory. Condolences for the family may be made online at www.shannonfuneralhomes.com.


text:
Ideas@ The Centre 22Vol. 7 No. 22 (July, 2009)
Fiscal activists can't have their cake and eat it
17 Jul 2009|
It was not that long ago that many economic commentators were talking of a direct trade-off between fiscal and monetary policy. Tax cuts and smaller budget surpluses, we were told, would lead to higher inflation and interest rates (strangely, the argument was rarely applied to increased government spending). Some economists were even brave enough to quantify this supposed trade-off.
Poor people can't eat good intentions
17 Jul 2009|
Apparently, politics is simple. Either you are good and care for people, or you don't.
Indigenous housing built on words
17 Jul 2009|
If only houses were built of words instead of stones, the government would be well on track with its Indigenous housing program. As it turns out, its much celebrated Strategic Indigenous Housing and Infrastructure Program (SIHIP) is not half as good with bricks and mortar as it is with the production of bureaucrat speak.


text:
Another of the great raptors in California (as well as North America and beyond, for that matter) is the Northern Harrier. Unlike a lot of the raptors we see riding high on the thermals, the Northern Harrier swoops down low over the upland grasses and marshes where it finds food, cover, and nesting. The Northern […]
Entries from April 30th, 2012
Northern Harrier on the wing
April 30th, 2012 · Comments Off · Audubon California, Bird Habitat, Bird videos, Birding, Landowner Stewardship, Pacific Flyway, Pacific Migration, spring migration, Video, Working lands conservation
Tags: Northern Harrier·Pacific Flyway·pacific migration·spring migration
Bullock's Orioles — big time
April 30th, 2012 · 1 Comment · Birding, Pacific Flyway, Pacific Migration, spring migration
Almost exactly a month ago, we trumpeted the early arrival Bullock's Orioles to California as part of spring migration. Well, now they're here en masse. This colorful bird started leaving its winter grounds in southern Mexico in early March and started hitting California soon afterward. Now, we're getting sightings of them throughout the state. People are […]
Tags: bullock's oriole·Pacific Flyway·pacific migration·spring migration
The Wanderer
April 30th, 2012 · Comments Off · Birding, Pacific Flyway, Pacific Migration, spring migration
With a name that sounds like something out of the original Batman TV series, the Wandering Tattler might be something of a disappointment for those that happen upon this unspectacular looking shorebird. But, alas, this bird has intrigued researchers for decades. Wintering along the west coasts of Northern America, Central America, and South America — […]
Tags: Pacific Flyway·pacific migration·spring migration·wandering tattler
Can birds be harassed?
April 30th, 2012 · 4 Comments · Bird conservation, Federal Policy, Pacific Migration, spring migration
A lawsuit filed in Iowa City, Iowa is bringing into question the constutionality of the Airborne Hunting Act. The Airborne Hunting Act prohibits and provides a penalty to any person who "while airborne in an aircraft shoots or attempts to shoot for the purpose of capturing or killing any bird, fish, or other animal; or uses an aircraft […]
Tags: air travel·ethics
Rough and tough migrators
April 30th, 2012 · 1 Comment · Pacific Flyway, Pacific Migration, spring migration
A familiar summer presence in many American backyards is the Northern Rough-winged Swallow. This common little brown bird is being reported in high numbers all over California, having migrated back from its winter home. These sightings were entered into eBird December 2011- February 2012. The bird received its name because of its serrated wings. Research […]
Into the water like a dart
April 28th, 2012 · 3 Comments · Birding, Pacific Flyway, Pacific Migration, spring migration
The sight of an Osprey hitting the water is genuinely breathtaking. A huge bird, perhaps even awkward in some circumstances, it turns into a perfect aerodynamic dart the moment before it strikes the water to grab a fish. And why shouldn't it be such a good fisherman? It is, after all, the only bird on […]
Tags: osprey·Pacific Flyway·pacific migration·spring migration·the ultimate fisher
Welcome, Mr. Lawrence
April 28th, 2012 · Comments Off · Birding, Pacific Flyway, Pacific Migration, spring migration
Another of the great birds of spring in California is the Lawrence's Goldfinch. Although there is a small population of year-round birds in southern California, most of them spend the winter in Arizona, New Mexico and Mexico and then come up into California in March and April. We've been enjoying them for some time in […]
Tags: lawrence's goldfinch·Pacific Flyway·pacific migration·spring migration
A rushing around a chimney
April 27th, 2012 · Comments Off · Audubon Center at Debs Park, Pacific Flyway, Pacific Migration, spring migration
Starting to see large numbers of Vaux's Swifts around the state. Here's how they looked at the end of Marc, but look at them now. It should be noted that the spring migration doesn't result in some of the terrific concentrations of birds that we see roosting spectacularly in chimneys (see video below). But we […]
Tags: Pacific Flyway·pacific migration·spring migration·vaux's swift
Kind of Blue: Blue Grosbeak arriving in California
April 27th, 2012 · 1 Comment · Birding, Pacific Flyway, Pacific Migration, spring migration
So, we've talked about the bluebirds and the dazzling Indigo Bunting, so now it's time to talk about another bluish bird, the Blue Grosbeak. The Blue Grosbeak is a wonderful species that winters way down in the Mexico and Central America, and visits the southern United States every spring to breed. Here in California, it […]
Tags: Blue Grosbeak·Pacific Flyway·pacific migration·spring migration
Golden Eagle on the move
April 27th, 2012 · Comments Off · Audubon Chapters, Birding, Pacific Flyway, Pacific Migration, spring migration
Let's just go ahead and say that the Golden Eagle is one of the world's greatest birds. It's an amazingly adaptable species, occurring widely throughout the Northern Hemisphere, relying on both arctic and desert habitats. In North America, it is primarily seen in the West, and in California we have both year-round residents and birds […]
Tags: Golden Eagle·Pacific Flyway·pacific migration·spring migration
Counting birds at Owens Lake
April 27th, 2012 · Comments Off · Audubon California, Audubon Chapters, Bird conservation, Bird Habitat, Birding, Important Bird Areas, Pacific Flyway, Pacific Migration, spring migration
Audubon California joined folks from Eastern Sierra Audubon and lots of enthusiastic volunteers for the Owens Lake Big Day earlier this week. We were counting shorebirds at the lake, compiling invaluable data which will help us secure lasting protections for this Important Bird Area. Audubon California and Eastern Sierra Audubon are working with the Los […]
Tags: Important Bird Area·Owens Lake·Owens lake big day·Pacific Flyway·pacific migration·spring migration
Birding is cool/hip/happening/rad/sick/groovy or whatever the kids are saying these days
April 26th, 2012 · Comments Off · Birding, Nature education and activities
We sort of feel like saying "I told you so" but this press release from The Outdoor Foundation say's it much more eloquently: The research (from The Outdoor Foundation) shows increases in youth and young adult participation – continuing an encouraging, yet modest, trend over the last few years. The study found that outdoor participation […]
John James Audubon's birthday calls to mind his namesake warbler
April 26th, 2012 · Comments Off · Birding, Pacific Flyway, Pacific Migration, spring migration
So, in honor of John James Audubon's 227th birthday, we thought it would be fun to shine the spotlight on the spring migration of his namesake bird, the Audubon's Warbler. Turns out it's not quite as easy as all that. For starters, some time ago, the western Audubon's Warbler was "combined" with the eastern Myrtle […]
Tags: audubon'a warbler·Pacific Flyway·pacific migration·spring migration·yellow-rumped warbler
Swainson's Hawk's annual ruling of our Central Valley looking better by the day
April 25th, 2012 · 2 Comments · Birding, Pacific Flyway, Pacific Migration, spring migration
You can talk to some California bird enthusiasts about warblers and shorebirds and swallows in spring migration, but all they really want to hear about are Swainson's Hawks. And, really, it's pretty understandable. The Swainson's is pretty awesome and its migration is unique. It comes all the way from Argentina to breed in habitat throughout […]
Tags: Pacific Flyway·pacific migration·spring migration·Swainson's Hawk
Birds make like Richard Hatch and form alliances
April 25th, 2012 · Comments Off · Uncategorized
A study from Oxford University in England provides proof that birds form alliances not unlike those of Survivor contestants. Researchers studied Great Tits and observed that the birds will band together to protect their nests. This anti-predator behavior is call "mobbing" and will only occur if the Great Tits have had neighboring nests for a […]


text:
Whats a good price for a mid-war Colt 1991A1??? Nothing that I'd be afraid to shoot. I've wanted one for some time, just haven't put the time toward the research needed to determine what is what and how much i should pay.
Results 1 to 4 of 4
Thread: A typical mid-war Colt M1911A1.
Remove Ads


text:
I started looking at Encog recently when the ConsoleApp example named "Forex" attracted my attention. Tried running it, it was throwing an exception.
Traced the exception, was resulted from _lamba going /10 till reaching zero, tried to apply a dirty fix, by skipping the Iteration method completly if lamba is zero, however I realized this is not right.
Heard later that the C# classes are a converted from Java, so went to check the Java class. Looking at it appears that the Java class is not an exact replica of the C# class. On the forum, César Souza also mentioned that the class is a clone of his class, so went checking in his Accord.NET framework as well.
Conclusions: the java class of Encog is a simillar code as Accord.NET implementation. The C# class implementation is not.
Recommended change:
if (decomposition.IsNonsingular) { _deltas = decomposition.Solve(_hessian.Gradients); UpdateWeights(); currentError = CalculateError(); }
if (!decomposition.IsNonsingular) continue; _deltas = decomposition.Solve(_hessian.Gradients); UpdateWeights();
with this change the code should have the closer to the Java behavior. I'm not sure it is the same as the Java code with just this change. Will keep looking and make another post once I find a complete list of changes of the C# class to match the Java implementation.
I would request that a member of the Encog team checks that the code is as intended and if the association with Accord.NET by César Souza is accurate, the code should be re-checked against that as well.
Please apply the patch to the GIT repository or tell me what is the protocol for checkin.
That will actually be addressed in 3.1. We originally used the Accord.Net implementation of LMA. But it is pretty limited, it got rewritten on the Java side. Most of the issues we had with the accord version was a few calculation bugs, limitation to a single layer, huge memory requirements, single threaded, and limitation to a single output neuron Jeff rewrote the Java side of LMA to address all of these issues with the Accord version. So checking to it would not be useful at this point. I think they have since fixed a few of the bugs....
However, we still need to port the Java side to .Net, and that is on the list for 3.1, and it will solve the issue you are referring to.
First of all, the typical path for checking a change into Encog is to fork the GitHub repository and then push you change to us. Which is typical for Git projects. Then we can review the change, and if accepted you are credited as the one who made the change. The following is a good summary of how to contribute.
Seema, the I have ported the Java code to C# so that step is not needed.
LSI, what version of Encog are you comparing the Java and C# implementations? In 3.1, which we are just about ready to release, they are the same.
These are both based on the newer version of LMA that I created after removing the Accord version (Encog 3.1). The biggest problem I had with the Accord version is that it makes use of a very large Jaccobian matrix that has a row for each training set element. On a large training set with a large neural network that blows out the memory real fast.
I will take a look at the change you suggested and implement it if all checks out okay.
Hello Jeff, John,
I just wanted to mention that the current version of the Levenberg-Marquardt learning of the Accord.NET Framework also has been updated and does not suffer from those limitations anymore. The code is now multi-threaded, supports multiple outputs and multiple hidden layers and the gradient calculation bug has been fixed. The Accord.NET still computes the Jacobian, but now uses an optional gradual construction approach which could be used to trade speed for memory and vice versa.
By the way Jeff, I also implemented an in-place version of the Cholesky decomposition and an in-place inverse trace calculation which could also be useful in Encog. It increases speed neatly as it is not necessary to compute the whole inverse matrix only to update the Bayesian regularization hyperparamenters. If Encog doesn't already do that, feel free to use the same technique in Encog as well. It improves performance a lot when using Bayesian regularization.
Best regards,
Cesar, thanks! Will take a look.
Also just checked in a change (Java and C#) that should prevent the lambda zero issue on a non-signular.
Since I am not reproducing the issue you are seeing I am mostly guessing at what you are encountering. LMA works by using lambda to interpolate between GNA and Gradient Descent. A low(or zero) lambda would happen is training is successful each time and lambda just continues to get pushed to the GNA side of things.
But even if I fix lambda at zero, I am not getting any sort of exception. I can easily impose a hard minimum on Lambda. But I still can't see why that is necessary. What is the stack trace you run into when lamda hits zero? If I can see why that is happening then I will put in a minimum on lamda... but just want to be sure that is really the issue.
Sure, any sort of distributed training example would be useful.
The C++ client mainly gives me direct access to the GPU API, in this case CUDA. It is also one less layer to go through. The problem on the GPU is that often the transfer time between the host and GPU will eat up any performance gain the GPU gave you. So while I experiment with getting the best performance from the GPU, pure C/C++ is the best environment to experiment with.
Encog releases are typically a mix of C# and Java improvements. Depending on which contributor is working on what. Then they get translated to the other side. I typically work on the Java side first. I do like the new C# improvements for threaded loops, and will probably move some of the code over to that, at some point. The C# code reminds me of C/C++ OpenMP, which is pretty nice! The Hessian calculation is a natural place the 4.0 threading improvements could be added, rather than the thread pool it uses now.
I tried imposing a floor on lambda, and I actually got worse results. I really suggest you DO NOT make that change. I also tried hard-fixing lambda at zero and got no exception.
Theme by Danetsoft and Danang Probo Sayekti inspired by Maksimer


text:
time.26 The committee is in general agreement with the appraisals of the reactor safety study conducted by the American Physical Society study group27 and more recently by the Reactor Safety Review Group.28 WASH-1400 contains some estimates that are excessively conservative and others that are almost certainly too optimistic. Which way this would shift the median probabilities for accidents of various severities is uncertain. The consequences of given accidents are apparently underestimated, but probably by not more than a factor of 3. However, the uncertainties in the probability estimates are almost surely several times larger than estimated in WASH-1400. If larger uncertainties are used, the mean, or expected number of fatalities from nuclear accidents, could be higher by a factor of 10 or more than the median values given by WASH-1400 (namely, 0.025 delayed deaths per reactor-year).*†
Catastrophic accidents can also occur in the case of other energy sources, especially large hydroelectric facilities. Between 1918 and 1958, an average of 40 deaths per year resulted from dam failures in the United States, though fewer in the more recent period. Some individual failures killed hundreds. Worst-case scenarios for both dams and LNG facilities lead to numbers of casualties comparable to those associated with the more severe nuclear accident possibilities. The calculated probabilities are higher, although the analyses on which they are based have been much less thorough and systematic than those for nuclear plants.
In the case of the most likely nuclear accidents, most fatalities would be delayed deaths that could not be specifically attributed to nuclear power, due to the exposure of a large population to low-level radiation (chapter 9). Casualties from dam failures and LNG accidents are immediate, with fewer delayed effects. Because such a high proportion of the reactor-related deaths are delayed, and because large populations may be at risk (even though the enhanced risk to any individual may be small), reactor accidents may create much greater apprehension than other types of catastrophic accidents that can cause the same number of fatalities.
Nuclear plants, dams, and LNG facilities are probably similarly vulnerable to sabotage, but nuclear plants are presently better guarded and may be inherently easier to guard. The consequences of sabotage of nuclear plants appear to be in about the same range as those of the severest postulated accidents discussed in WASH-1400.‡ The possible severe consequences could be much higher, though, because saboteurs could choose times and places for maximum effect. The safety analysis techniques developed for assessing nuclear reactor accidents ought to be
See statement 1–53, by J.P.Holdren, Appendix A.
Statement 1–54, by L.F.Lischer: Critiques of WASH-1400 have emphasized that uncertainty ranges are larger than originally stated, both higher and lower.
See statement 1–55, by L.F.Lischer, Appendix A.


text:
Members of the House voted 273-156 in an attempt to override the presidential veto of the popular children's health insurance program, falling short of the two-thirds majority needed.
U.S. Rep. Peter Welch, Vermont's Democrat in the House, voted with the majority as expected.
UPDATE: Here's Welch's statement.
"President Bush and his allies in Congress have once again demonstrated that they are completely out of touch with the needs of working families. Vermonters long ago recognized that providing children with health care is both cost effective and the right thing to do. The President has no problem pouring hundreds of billions of dollars into a failed policy in Iraq, yet he turns a deaf ear to hard working Americans who simply want to bring their children to a doctor when they are sick. His stubborn refusal to help these children is a national disgrace."


text:
Rajasthan Post Office Recruitment 2015 – 2016
Rajasthan Post Office Recruitment 2014-15 The Department of
Rajasthan Post Office Recruitment 2014-15
The Department of Posts India has issued a recruitment advertisement for 53 positions of Multi Tasking Staff at different divisions in the Rajasthan Circle. Applicants will be shortlisted for this recruitment through an Aptitude Test conducted by the Indian Post. Keen applicants are advised to go through the following particulars for more details of this job opening and send their applications within the prescribed last date of 5th April, 2014.
View more for Latest Post Office Recruitment Details
Division of Vacancies:
For General : 29 vacancies
For SC : 4 vacancies
For ST : 4 vacancies
For OBC : 9 vacancies
For PH : 2 vacancies
For Ex.S : 5 vacancies
All eligible candidates will be remunerated with INR.5,200- 20,200/- along with a Grade pay of INR.1,800 and additional acceptable allowances.
Age Bar:
Applicants' age must strictly fall between the ages of 18 to 27 years. Those who do not accomplish this age limit will not be eligible for this recruitment. However, candidates belonging to reserved categories will be provided with suitable relaxation as per latest government rules.
Academic Requisites:
Interested candidates must be in possession of their Matriculation or ITI under any documented Board of Education or University.
Click here for Post Office Recruitment Application Form Details
Hiring Process:
Suitable candidates will be recruited for these positions through an Aptitude Test. The final merit list will be set on the grounds of the aggregate marks obtained by the aspirants in this Aptitude Test. Applicants who do not attend or crack this exam will not be eligible for this job opening.
Intimation Charges:
All interested unreserved (General & OBC) applicants are supposed to remit an Examination fee of INR.400/- through e-payment at any post office under the Rajasthan Postal Circle if looking forward for this recruitment. However, applicants belonging to reserved categories will be exempted from this aforesaid charge.
Application Methodology:
Qualified and keen aspirants may obtain the application forms from 5th March, 2014 onwards from all Head Post Offices in the Circle by a cash payment of Rs.100. Once obtained, applicants must read the instructions provided along with that form carefully and fill it up accordingly. These duly filled in forms must be sent to this address accompanied with the original e-receipt issued by any PO of Rajasthan Circle towards the payment of Examination fee on or within 5th April, 2014:-
Direct Recruitment Cell,
Office of Chief Postmaster General,
Rajasthan Circle,
Sardar Patel Marg, Jaipur-302007.
Follow this link for official recruitment notification.
More Jobs For You
Comments - Review
Post Your Comment
Placement Papers
Job Update by SMS
Job Alert on Mobile
On SarkariexamAlert to
- Vacancy in ECIL/Last date:03-Aug
- Vacancy in HPCL/Last date:31-Jul
- Vacancy in Chennai Metro Rail/Last date:29-Aug
- Vacancy in Uttarakhand Forest/Last date:13-Aug
- Vacancy in Uttarakhand Gramin Bank/Last date:12-Aug
- Vacancy in ONGC/Last date:17-Aug
- Vacancy in India Post Office/Last date:25-Aug
- Vacancy in Aryapuram Cooperative Bank/Last date:13-Aug
- Vacancy in Bharat Electronics Ltd. (BEL)/Last date:10-Aug
- Vacancy in Kolkata Port Trust/Last date:31-Aug
- Vacancy in MSTC Ltd./Last date:17-Aug
- Vacancy in Indian Coast Guard/Last date:17-Aug


text:
If the game freezes, just click inside it (games can get unresponsive if you click elsewhere on the page).
The alien ship is docked by an earth shuttle containing CY10 the advanced humanoid cyborg that has recently been in contact with those on the planet surface. The cyborgs must try to regain control of the station damaged during various emergencies caused by creatures carrying the madness virus. There is only one way the virus could already be here. Thorenzithans are aboard. Was the virus brought up by accident or deliberate?
WASD keys/Arrow keys- To move.
Enter/Space bar- Actions.
Mouse- Aim and fire.
P- Pause game.


text:
Rep. Kurt Wright, R-Burlington, issued a statement Friday afternoon complaining about the criticism the Vermont Democratic Party sent his way over his Thursday vote on a budget adjustment bill.
The party singled Wright out because he is running for mayor in Burlington.
When the bill came up for preliminary approval Thursday, Wright joined the House Republican caucus in voting against the bill. The caucus objected to the provisions in the bill that would allow the Shumlin administration to fill 50 positions. That much hiring shouldn't be considered as part of a bill making technical fixes to the spending plan lawmakers authorized last spring, Republicans argued.
Democratic Party Chairman Jake Perkinson charged, "Even where good program initiatives will result in financial savings and tremendous social benefits, Kurt Wright followed the obstructionist game plan of his Republican Party that is cynically applied in Washington D.C., throughout the country and now at home in Vermont."
Wright switched sides when it came time for the final vote on the budget bill Friday, joining a largely Democratic block in supporting the bill. As a result, he objected to the Democratic complaint, which appeared Friday in email boxes, calling it misleading. He was one of seven Republicans who voted for passage of the bill.
There aren't always two roll call votes on bills, but since the House voted twice on this legislation, both sides have a record to point to for this political fight.


text:
Course Schedules
To all users: The course schedules content on this page lives in an older version of Guilford's website. If you need any information other than course schedules, return to the current Guilford website by relaunching guilford.edu in your browser. We are sorry for any inconvenience.
Schedule, General Education Requirements and Courses for IDS Majors
|Choose a Term:


text:
Staff Reports
The Better Business Bureau (BBB) has issued a nationwide warning about a new scam claiming that President Obama will pay your utility bills through a new federal program.
Consumers have been contacted through telephone calls, fliers, social media, text messages, and word-of-mouth with claims that the federal government is providing credits or applying payments to utility bills.
To receive the money, scammers claim they need the consumer's Social Security and bank routing number and/or account number. In return, customers are given a fraudulent bank routing number to use when paying their utility bills through an automated service.
The payment service initially 'accepts' the payment, but then declines it within a few days when the bank account number is discovered to be fake. The consumer's bill has not been paid, and their personal financial information and Social Security number have been compromised.
The BBB has these tips to avoid becoming a victim of this scam:
•Never provide your social security number, credit card numbe,r or banking information to anyone requesting to anyone who calls you, regardless of whom they claim to be representing.
•If you receive a call claiming to be your utility company and feel pressured for immediate payment or personal information, hang up the phone and call the customer service number on your utility bill.
•Never allow anyone into your home to check electrical wiring, natural gas pipes or appliances unless you have scheduled an appointment or have reported a utility problem. Also, ask utility employees for proper identification.
•Always think safety first. Do not give in to high pressure tactics over the phone for information or in person to get into your home.
For more information about identity theft scams, please visit the BBB online.


text:
Highlights of the bill
Highlights of a bill Congress passed Tuesday aimed at averting wide tax increases and budget cuts scheduled to take effect with the new year. The measure would raise taxes by about $600 billion over 10 years compared with tax policies that were due to expire at midnight Monday. It would also delay for two months across-the-board cuts to the budgets of the Pentagon and numerous domestic agencies.
The House and Senate passed the bill on Tuesday and sent it to President Barack Obama for his signature.
Highlights include:
Income tax rates: Extends decade-old tax cuts on incomes up to $400,000 for individuals, $450,000 for couples. Earnings above those amounts would be taxed at a rate of 39.6 percent, up from the current 35 percent. Extends Clinton-era caps on itemized deductions and the phase-out of the personal exemption for individuals making more than $250,000 and couples earning more than $300,000.
Estate tax: Estates would be taxed at a top rate of 40 percent, with the first $5 million in value exempted for individual estates and $10 million for family estates. In 2012, such estates were subject to a top rate of 35 percent.
Capital gains, dividends: Taxes on capital gains and dividend income exceeding $400,000 for individuals and $450,000 for families would increase from 15 percent to 20 percent.
Alternative minimum tax: Permanently addresses the alternative minimum tax and indexes it for inflation to prevent nearly 30 million middle- and upper-middle income taxpayers from being hit with higher tax bills averaging almost $3,000. The tax was originally designed to ensure that the wealthy did not avoid owing taxes by using loopholes.
Other tax changes: Extends for five years Obama-sought expansions of the child tax credit, the earned income tax credit, and an up-to-$2,500 tax credit for college tuition. Also extends for one year accelerated "bonus" depreciation of business investments in new property and equipment, a tax credit for research and development costs and a tax credit for renewable energy such as wind-generated electricity.
Unemployment benefits: Extends jobless benefits for the long-term unemployed for one year.
Cuts in Medicare reimbursements to doctors: Blocks a 27 percent cut in Medicare payments to doctors for one year. The cut is the product of an obsolete 1997 budget formula.
Social Security payroll tax cut: Allows a 2-percentage-point cut in the payroll tax first enacted two years ago to lapse, which restores the payroll tax to 6.2 percent.
Across-the-board cuts: Delays for two months $109 billion worth of across-the-board spending cuts set to start striking the Pentagon and domestic agencies this week. Cost of $24 billion is divided between spending cuts and new revenues from rule changes on converting traditional individual retirement accounts into Roth IRAs.
America's not going over the fiscal cliff, as the House of Representatives Tuesday approved the last-minute deal to pull the nation away from the brink of economic chaos.
The vote came quick and without much controversy, a calm and collegial finish to a turbulent day. The House approved the measure by a vote of 257-167 and sent it to President Barack Obama for his signature.
Third District Rep. Jaime Herrera Beutler, R-Camas, voted "yes."
"Thanks to the votes of Democrats and Republicans in Congress, I will sign a law that raises taxes on the wealthiest 2 percent of Americans while preventing a middle class tax hike that could've sent the economy back into recession and obviously had a severe impact on families all across America," Obama said at the White House.
Immediately after talking to reporters, Obama left the White House to fly back to Hawaii, resuming the vacation he suspended after Christmas to return to the capital for budget talks.
In the Congress, Republicans vowed to press on in the weeks ahead to cut spending in ways they could not in the fiscal cliff deal.
"Now the focus turns to spending," House Speaker John Boehner, R-Ohio, said in a statement after the vote. "The American people re-elected a Republican majority in the House, and we will use it in 2013 to hold the president accountable for the 'balanced' approach he promised, meaning significant spending cuts and reforms to the entitlement programs that are driving our country deeper and deeper into debt."
Reluctant House Republicans, concerned the plan had too few spending cuts and not enough meaningful debt reduction, had threatened to stymie the plan. Their fury was fueled further by a new report from the nonpartisan Congressional Budget Office that the package would add $3.97 trillion to deficits over the next decade.
But they also came to realize that scuttling the package could instantly put the nation's slowly improving economy in jeopardy. Tax rates had already gone up Tuesday, and automatic spending cuts were scheduled to kick in Wednesday.
In private meetings Tuesday, Republicans expressed concern that once domestic financial markets re-open after the New Year's Day holiday Wednesday, reaction to legislative gridlock could be severe. It's a risk, said Rep. John Fleming, R-La., "we all recognize."
As a result, the debate became a virtual celebration of bipartisan agreement. "After more than a decade of criticizing these tax cuts, Democrats are finally joining Republicans in making these tax cuts permanent," said House Ways and Means Committee Chairman Dave Camp, R-Mich. House Democratic Leader Nancy Pelosi, D-Calif., lauded the bill as a "very, very strong first step as we go into the new year."
The legislation, passed by the Senate 89 to 8 Tuesday morning, will postpone the automatic spending cuts for two months. Individuals making more than $400,000 - $450,000 for families - would pay a top income tax rate of 39.6 percent, up from the current 35 percent. Others would pay at 2012 rates.
The plan also ties the alternative minimum tax to inflation, a relief for an estimated 30 million taxpayers who could have been hit with higher bills. Other measures include an extension of jobless benefits for the long-term unemployed and avoiding a huge cut in Medicare payments to doctors for a year.
The vote in the House came after a day of furious closed-door lobbying - and arm-twisting. Vice President Joe Biden met for two hours with House Democrats. At the same time, Republicans met privately twice, for a total of nearly three hours. They heard opposition from Majority Leader Eric Cantor, R-Va., who has a strong following among conservatives. "There was a lot of discontent in that room," said Rep. Steven LaTourette, R-Ohio.
The congressional turmoil was no surprise. Republicans have long been unhappy with Democrats' reluctance to agree to big spending cuts, and were not pleased the latest deal delayed the automatic cuts.
"This does nothing about getting the $16.4 trillion debt under control, said Rep. Steve Chabot, R-Ohio.
Republicans made a last-ditch effort to pass more spending cuts, offering to consider the same package of $328 billion in cuts that passed on a party-line vote Dec. 20, but could not muster enough support Tuesday. Many Republicans worried that attaching the measure would never make it through the Senate, putting the entire fiscal cliff deal at risk.
"We don't want to do anything in the House that would create a poison pill for the Senate," said Rep. Raul Labrador, R-Idaho.
Few lawmakers in either party seemed happy with the plan, as the unease Tuesday crossed party and ideological lines.
"This punts the problem," said Rep. Raul Grijalva, D-Ariz. "It just sets us up for more fights."
But few dissenters spoke during the debate. Rep. James Moran, D-Va., said the bill will "set up three more fiscal cliffs," including fights over raising the debt ceiling and the sequester and said "and all that's left is the spending cuts. What programs do we cut and how deep? We're going to look back on this night and regret it."
House Republicans were not pleased that they had virtually no input into the deal, crafted by Biden and Senate Republican Leader Mitch McConnell of Kentucky.
LaTourette called the plan "a package by a bunch of sleep-deprived octogenarians."
The loudest protests came from the 87 Republican freshmen first elected in 2010, swept into office on a pledge to drastically slash federal spending.
"There is a resignation that the big steps forward my class wanted to take is not possible with this Congress," said Rep. Rob Woodall, R-Ga. "Only small steps forward are absolutely possible."
Whether he and others could accept such small steps was the key to approving the deal. Veteran Republicans argued the package was as good as they were going to get.
"Let's recognize we avoided what could have been a terrible outcome," said Rep. Tom Cole, R-Okla.
He urged resisting changes. "It's too late in the game," he said. "You can keep tinkering with this, but you're not going to make it perfect."


text:
Used cars for sale in Holton-Le-Clay
www.cheapmotors.co.uk currently has over 0 used cars for sale in Holton-Le-Clay
Welcome to the CheapMotors 'Used cars in Holton-Le-Clay' webpage. If it's used cars you are searching for in and around the Holton-Le-Clay area, and you are looking to buy a cheap second hand car soon - then we have an impressively large database of used cars in or near to Holton-Le-Clay for you to explore.
All the used cars listed on our site are for sale immediately, supplied from main dealerships, independent dealers and car supermarkets around the Holton-Le-Clay area.
Sorry no results matched your criteria.


text:
|« Back to Article
Freeze warning issued, Salvation Army to help
By Tricia Schwennesen, Staff Writer : November 13, 2013 : Updated: November 14, 2013 6:36am
More Information
Cold Weather Help
What: Distribution of warm drinks and transportation to Salvation Army shelters
When: 6-8 p.m. tonight Where: Frio City Road and Houston Street
Who: Salvation Army Canteen
SAN ANTONIO — The National Weather Service has issued a freeze warning beginning at 11 p.m. tonight and running through 9 a.m. Thursday.
Temperatures are expected to dip into the upper 20s and lower 30s, lows that could impact plants, pets, household pipes, livestock and the homeless.
If you need shelter from the cold or just something to warm you up, the Salvation Army will be out this evening offering warm drinks and rides to area shelters.
The lobbies of the Emergency Family Shelter, at 515 W. Elmira, and the Dave Coy Center, at 226 Nolan St., have been opened to the public to serve as warming stations. They will remain open for 24 hours.
The Goslinowski Social Services lobby, at 910 N. Flores, will also be open from 8:30 a.m. to 5 p.m. to anyone seeking shelter from the cold.
For those who want to help, the Salvation Army needs canned food, non-perishable items and bottled water. Clothes and household items are not needed at this time. Donations will be accepted at 521 W. Elmira St.


text:
Butler sends Wildcats to third straight home loss
Andrew Smith scored a season-high 24 points and Butler pulled away in the second half for a 74-65 win over Northwestern on Saturday night.
Find out more about: Hoops Rapid Recaps
August 1: Use Big Ten TeamTix to reserve face value tickets to see your team play in the Football Championship before they qualify!
Andrew Smith scored a season-high 24 points and Butler pulled away in the second half for a 74-65 win over Northwestern on Saturday night.
Find out more about: Hoops Rapid Recaps
Brian Spurlock-USA TODAY Sports
There are posterizing dunks, and then there is Victor Oladipo's in-your-face slam from Saturday night. Oladipo, he of several highlight-reel dunks in his two-plus seasons (remember this one?), threw down perhaps the best poke of his career in the first half against Central Connecticut State. In transition, no one accounted for Oladipo, and he drove to the rim, where Terrell Allen went for the block. Needless to say, Allen didn't get it.
Find out more about: Gone Viral, Victor Oladipo
Christian Watford scored 21 points, Cody Zeller had 19 points and 19 rebounds, and No. 1 Indiana routed Central Connecticut State 100-69 on Saturday. The Hoosiers (9-0) dominated on both ends of the floor.
Find out more about: Hoops Rapid Recaps
Indiana University's unofficial First Couple took in Saturday night's men's basketball game vs. Central Connecticut State. Yes, we're talking about John Mellencamp and wife Meg Ryan. The Hoosiers, in particular junior guard Victor Oladipo (Watch Oladipo's dunk-a-thon), treated the two celebrities to quite the highlight show. It was almost difficult to keep up with all the slams (Watch all of them here). See our camera catch Mellencamp and Ryan now.
Find out more about: Gone Viral
The Nittany Lion in a flight suit. The Nittany Lion balancing on a pair of rifles. The Nittany Lion marching and twirling a rifle. It was a special afternoon Saturday at the Bryce Jordan Center, as Penn State hosted Army, on the same day the service academy played its annual rivalry game vs. Navy on the gridiron. And with the Black Knights in town, the Penn State mascot teamed with Army Cadets to provide the halftime entertainment. Watch the Nittany Lion entertain the crowd now.
Find out more about: Gone Viral
The third-ranked Minnesota wrestling team rallied past No. 15 Oregon State, 21-18, Saturday night at the Sports Pavilion. The match came down to the heavyweight battle, and it was Minnesota's Tony Nelson notching a double-overtime victory over Oregon State's Chad Hanke. Watch our interview with Nelson now.
Find out more about: Student U


text:
By Jonathan Martini - September 18, 2003
Splinter Cell Benchmark Results
Splinter Cell is a very slow-paced game which places a great emphasis on
slowly sneaking around in the dark. As such, when running the timedemo, I
elected to keep the Shadow Level setting at high, as Splinter Cell wouldn't be
the same game without the sweet and important shadow effects. Shadow Mode was
left at the Buffer setting, which is the default setting for the GeForce class
of cards and is the recommended setting by Ubisoft. The settings I modified for
the various tests are the Shadow Resolution and Effects Quality settings. The
Shadow Resolution setting was set at High for the first two rounds of testing
then lowered to Medium for the last maps. The Effects Quality setting varied
from Very High to Medium.
Since Splinter Cell's focus is slow and quiet spying over the all-out-action
we're accustomed to seeing in the first person shooter genre, the game's
performance is considered playable at much lower FPS than is typically
considered acceptable for smooth performance when playing first-person shooters.
The first three maps have similar performance results which allows the game to
be smooth in most circumstances at 800x600 with the High/Very High settings for
Shadow Resolution and Effects Quality. The Beyond3D Caspian Oil demo takes it's
toll on the card as the level truly stresses the pixel shader paths of the card.
Tron 2.0 Demo Benchmark Results
The first of the games covered using FRAPS to measure the in-game performance
is the Tron 2.0 Demo. A very cool little game with an extremely unique art
concept wherein the characters and levels are composed solely of various shades
of black and illuminescent borders. The High Detail picture above displays how
truly illuminescent the borders can be. The overall effects is extremely cool
and brings much more to the setting of the game than the rather drab textures in
the Medium Detail setting. I wouldn't even consider playing the game at any
setting other than the High Detail setting. Doing so wouldn't do justice to the
game and all the cool glowing effects provided by the Lithtech engine.
Being one of the most popular online games at the moment, performance numbers
from Battlefield 1942 couldn't be overlooked. I tested the recent Secret Weapons
of WWII demo as I've been hooked on it since it was released a few weeks ago.
Testing the performance was a tad different than other games where I'd just let
FRAPS count the frames and post the average. There's a couple reasons for this:
1 - The performance of the game when waiting to spawn was a tad different than
in-game performance 2 - I was waiting to respawn quite often. ;) Therefore I
would activate FRAPS' framerate logging system when I would respawn, try to do
some damage and then deactivate it the moment I would be killed. After about an
hour of playing I had a huge list of scores with the average framerate being
right up around 50 FPS at 800x600. Very acceptable performance for a relatively
low-priced card in a game that was reputed to be resource heavy at launch.
F1 Challenge '99 - '02 is a fairly uncommon game to be included in the
review. I burned so much time into this game, that neglecting all that would be
quite a waste (not to mention featuring a racing game is a nice change of pace
from all the first person shooters so dominant in video card reviews). I'm a
great high-speed driver, as such my favourite tracks are Austria's A1-Ring and
Italy's Monza circuit. Performance between tracks tend to stay fairly similar
hovering around 60 FPS on a nice clean track with a few cars in close proximity.
The graphic settings for the test was set at Full, which maxes out all the
settings such as viewing distance, car detail, shadows, mirror reflections etc.
The overall gaming performance of the GeForce FX 5200 Ultra surprised me as I
wasn't expecting much out of such a low-priced card. While you can't expect to
crank every setting to its highest level or enable anything beyond 2X FSAA in
every game and still get acceptable performance at resolutions above 1024x768,
most gamers looking for a card in this price range couldn't be asking for much
Next Page: 3DMark2001 SE and ChameleonMark
Last Updated on September 18, 2003