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Therapists: 1 to 20
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Therapists in 51503
Verified by Psychology Today
Brigette Maas
Clinical Social Work/Therapist, LISW, LMHP, RPT, LCSW
"Brigette Maas began her career over 11 years ago in the medical social work field. While working in Oncology, Medical-surgical, Emergency Department, ICU, NICU, and Labor and Delivery units in the Omaha area, she enjoyed connecting patients with support and community resources. Because of her passion in mental health and recovery, she transitioned to partial and acute psychiatric settings. After completing her play therapy certification, she embraced an opportunity to open a private practice serving children, teens and adults through individual, group, and family therapy.
(712) 264-5683 x1
Verified by Psychology Today
Chad Richter
Counselor, MS, LMHP, LMHC
"With more than 12 years experience, I have specialized in working with diverse populations including children, adolescents/at-risk youth, and adults. My core work focuses on depression, bipolar disorder, severe and persistent mental illness (SPMI), anxiety/panic attacks, physical/emotional abuse, anger problems, grief, self-esteem, ADHD, PTSD, addiction, work/vocational issues, school/truancy, homelessness and parenting difficulties.
(402) 609-7183 x108
Verified by Psychology Today
Jamie Przybylski
Counselor, LMHC, LIMHP
"Are you feeling less happy or even sad, experiencing a decrease in energy, losing interest in things you enjoyed? Does the swirling around of thoughts at night make it difficult to fall asleep? Have you been feeling down on yourself or that you aren't "good enough?" Do you find it difficult to keep your life in balance? I can help reduce your pain and problems and move you towards solutions and comfort. I offer a two phase approach in helping you with these problems so you can better manage the hard parts of life and enjoy life more.
(712) 631-5722
Verified by Psychology Today
Amy Riessland
Clinical Social Work/Therapist, LISW, RPTS
"I have been practicing mental health therapy for 8 years. I have experience working with children/parents, adolescents, and adults who are facing depression, anxiety, trauma, PTSD, loss, or life changes that they are struggling to cope with.
(712) 560-9055
Verified by Psychology Today
Kate Kathleen LaRaine Cross
Counselor, MA, LMHC, LIMHP, EMDR, RPT
"I am licensed in Iowa and Nebraska. My theoretical orientation is empowered by Action Oriented Theories integrating; Scripture, Cognitive Therapy, Rational Emotive Behavior Therapy. By magnifying thoughts, beliefs, we work to enable healing, empowering self-awareness, acknowledgement, and honest portrait of reality. I welcome children-adolescents, women, seniors, and families. I have EMDR certification and utilize Play Therapy techniques. I specialize in relational communication, self-esteem, confidence, parenting, anxiety, depression, grief. I believe that the goal of the client is to seek resolutions for presenting problems. These often create despair which multiplies into a range of negative affects.
(712) 587-8792
Verified by Psychology Today
Earl T Anderson
Counselor, MS, LMHC, LMHP
"If you are depressed, angry, stressed, want help with relationships,or have loved ones with behavior problems, I can help.
(402) 527-1141
Verified by Psychology Today
Kelly Deroos
Counselor, LMHC, NCC
"I have 20 years of experience working with Children and Adolescents. Most recently 10 years at Alegent Creighton Health Mercy Hospital in the Acute Psychiatric Department of all ages.I am experienced in working with clients dealing with Depression, Oppositional Defiant Disorders, Addictions, Grief and Dual Diagnosis. I also volunteers with Ted E Bear Hallow. I look forward to working clients using a Cognitive Behavioral Therapy approach to help them achieve goals and improve their lives during a challenging time in their life.
(712) 264-5366
Verified by Psychology Today
Shelie Leighter
Clinical Social Work/Therapist, MA, LISW, RPT
"Being able to live a life full of happiness, contentment and satisfaction is so important, yet in today's world can be so difficult to do. I believe that everyone has the potential to achieve emotional wellness and a sense of balance in life. I am dedicated to providing a therapeutic relationship that allows for a sense of safety, warm acceptance and empathy. I pride myself on being open-minded and allowing each person to guide their own journey to mental wellness through an ongoing dialogue about their needs and concerns.
(712) 574-8813
Verified by Psychology Today
Katie Ladd, LISW--Kanesville Therapy
Clinical Social Work/Therapist
"Are you or your child struggling with a recent change? Most stress and challenges in life originate from a disconnection somewhere along the journey. My mission is to provide support for children and adults by helping others reconnect with themselves, with their priorities, their values and their loved ones. I focus on change as natural part of life, in harmony with reconnection. Contact me today if you are ready to kickstart the next chapter in your journey. I specialize in child trauma and abuse, as well as early childhood social skills and challenging behaviors in children.
(712) 291-3544 x4
Verified by Psychology Today
Morgan Kupsinel
Clinical Social Work/Therapist, LISW, IADC
"I have worked with/for people whose lives have been negatively affected by different issues. It's easy to think of these issues in negative terms. But I have learned that nonjudgmental acceptance is preferable. I have experience working with individuals with serious mental illnesses such as schizophrenia, anxiety, depression, or bipolar disorder, personality disorders, emotion regulation problems, chemical use problems or being in a relationship with someone who has chemical use problems, brain injury, divorce or separation from family members, traumatic events or a series of traumatic events, and growing up in homes with inadequate parenting.
(402) 260-5319
Verified by Psychology Today
Helen Jackson Bleicher
Counselor, MA, LMHC, LIMHP, RPT
"In a safe, respectful, and responsive manner, I provide counseling services to children, teens, adults, and couples. My counseling services support individuals through challenging times that occur throughout their lives by providing a means to positively cope, to adapt and to learn from these times. Ultimately, I wish for individuals to move forward with their lives and to regain a sense of hope for their futures. This is accomplished by using a variety of techniques; mainly reinforcing positive thought patterns, applying constructive coping outlets; as well as incorporating play therapy techniques.
(712) 587-6157
Verified by Psychology Today
Lisa Kee
Counselor, LISW, MSW
"People are unique, and I help them make changes by entering into a relationship that honors who they are. This relationship fosters a safe place to heal old wounds, explore the vast realm of possibility, and reach a more peaceful state of mind, body, and spirit. To enhance our work together, I am experienced in many ways to communicate and integrate information. This may include traditional talk therapy, Parent Child Interaction Therapy, play and art therapy techniques, and EMDR as a tool to enhance insight into oneself and a person's role in relationships and their environment.
(712) 274-3572
Verified by Psychology Today
Laura Kinney
Clinical Social Work/Therapist, LISW, LCSW, LMHP, PLADC
"Your therapist has to be the right fit for you; choosing a therapist is a very personal decision. Your safety and rapport with your therapist are the deciding factors on whether therapy will be successful. Are you experiencing difficulty recovering from trauma, anxiety or depression, or the impact of substance abuse in your or a loved ones' life? No matter what method I am using, ensuring a strong working alliance with my clients allows them to do the healing work they need to thrive.
(712) 522-5886 x3
Verified by Psychology Today
Barbara A. Gobel LICSW
Clinical Social Work/Therapist
"All you want to do is to feel calm again, to take a step back so you can feel normal again. You deserve to feel relaxed. Perhaps you are wondering, "Is it ever going to get better?" Perhaps you are wondering, "Is my kid more anxious than other kids? Why is she always worried? Is this normal?" You're not alone. There are many ways you can learn to feel more at peace, and your child can too. With help, and an unbiased person to talk to, you can find peace and serenity. Hope is renewed, your family can begin to feel normal again.
(402) 318-5151
Verified by Psychology Today
Nathan J Seadore
Counselor, LPC, LMHC, LMHP
"Does something need to change in your life? Does something just feel off, and you aren't sure what or why? Feel like a cartoon character walking around with a storm cloud following you? Did something happen to you that you didn't deserve, or did you experience something painful that still feels fresh? Mental Health can be a mysterious stranger who lingers in your life unexamined or unquestioned, and it can affect every aspect of your being from work, family/kids, and other significant relationships. Most importantly it can distort what you see in the mirror everyday.
(712) 522-4572
Verified by Psychology Today
Gina Michelle West-Hendrickson
Counselor, LMHC, RPT
"I am a licensed mental health therapist with experience working with person's of all ages. I utilize a variety of therapy techniques from Cognitive Behavioral therapy, Art therapy, EMDR and Sand Tray and Play therapy techniques. I have specific training in Play therapy techniques from KC play therapy. My focus is to develop a treatment plan that is unique and specialized for your needs and concerns.
(402) 835-0944
Verified by Psychology Today
Jackie Marcum
Counselor, NCC, LMHC, RPT
"My goal as a counselor is to work with individuals and families, helping them to process issues they are struggling with. I believe every single person has unique assets that need to be realized and utilized. I help clients find those assets and build on them to bring about positive change and a healthy sense of well-being.
(402) 415-2493
Verified by Psychology Today
Daybreak Counseling
Clinical Social Work/Therapist
"Yes! I take BCBS (and other major insurances). Talking to the right person can be extremely helpful in a comfortable and private setting. My counseling style is open and respectful. I offer a confidential and safe experience to clients who want to begin privately and peacefully to sort out their thoughts,and feelings,and to make good decisions. Fear, sadness, anger, & confusion happen to everyone. But "stress overload" or "emotional distress." drags us down, It changes our outlook & affects the ways we react or interact. Living in a state of constant stress changes who we are.
(402) 620-6165
Verified by Psychology Today
Yeshim Oz
Counselor, MA, MS, LIMHP
"Every person is unique and capable of realizing his/her potentials in an optimal environment. However, life is filled with so many challenges and it is not unusual to feel discouraged or unable to meet those challenges. Building a relationship based on acceptance and trust with my clients is my priority. I listen carefully and help them develop an understanding of what has led them to unsatisfying thoughts, feelings and behaviors. We explore and identify how significant past experiences have shaped their present life.When working with children, parents are essential part of the therapy and always welcome to collaborate.
(402) 318-5205
Office is near:Council Bluffs, Iowa 51503
Verified by Psychology Today
Jim Haley
Psychologist, PhD, NCC
"I believe empathy, collaboration, and motivation are vital in counseling. As a clinician, I want to learn about what has gotten you to this point. I offer a safe, nonjudgmental environment to help facilitate this. I am particularly interested in your strengths, resources, past efforts, and goals including what you feel can and can't be done. I believe most problems stem from suppressed emotions, interpersonal difficulties, environmental stressors, or distorted beliefs and assumptions. Together, we will work to select the most effective course to achieve changes you want and need.
(402) 330-1537 x16
Office is near:Council Bluffs, Iowa 51503
Not enough Therapists in Pottawattamie County, Iowa (IA), 51503 to choose from?
Try expanding your search for Therapists in 51503 to a larger area (e.g. click the plus sign or 51503+ .)
How can I tell if a therapist is right for me?
Therapists in 51503 have broad skills and are able to work with a wide range of issues.
For example, if you're seeking a marriage counselor in 51503 you'll find that most therapists are trained in marriage counseling or couples counseling in 51503 and couples therapy. And they welcome families for family counseling in 51503 or family therapy in 51503.
How to find a specialist?
If you're looking for specialist counseling in Pottawattamie County, Iowa 51503, such as a child psychologist or sex therapist, try to refine your search with our left nav bar.
What method of therapy is right for me?
When it comes to treatment methods, there's no "right way". A couples counselor or a family counselor may use different treatment methods depending on the one that works best for you.
How to use my insurance?
Many therapists accept health insurance. Check to see if your insurance is covered. Feel free to discuss this when you contact the therapist.


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Radio Actuality
Secretary Salazar Tells Indian Country Recovery Package Includes Major Initiatives to Create Jobs, Stimulate Economic Activity
Secretary of the Interior Ken Salazar, speaking to the to the 111th Congress of American Indians Tribal Nations Legislative Summit, today highlighted more than $2 billion in President Obama's economic recovery package to create jobs and economic opportunity in Indian Country.
Topic / Summary / Transcript
Topic: The Secretary says close to a half billion of the money will come through Interior Department Programs.
"Through the Department of Interior we fought for and we were able to receive $450 million dollars to fix roads and to repair and construct schools and to strengthen detention centers and to bolster law enforcement. We were able to get $40 million additional dollars for housing improvements and for workforce training. So that is close to half a billion dollars that will come through the economic stimulus package to help Indian country."
Topic: Secretary Salazar says that Indian country will play a key role and benefit economically from the administration's renewable energy development plans.
"As we move forward with what will be a virtual energy revolution for the United States of America, that Indian country should not be left behind, that you should be at the table. So as we harness the power of the sun in the construction of what will be 350 megawatt solar power plants across the Southwest or in the Great Plains of the Dakotas we harness the great power of the wind to bring about renewable energy, we need to make sure that the Native American communities are also participants and beneficiaries of that renewable energy revolution."
Topic: Secretary Salazar pledges to make education a top priority.
"One of the responsibilities that I take most seriously is the responsibility that we have in working with the BIE to make sure that the 49,000 children that we have educational responsibility for along with the Indian tribes that we do the very best so we can. And so we will very hard to make sure that schools are constructed, that we have the right kinds of teachers to provide teaching in those schools and that we do not leave our children behind. That I commit to all of you." (applause)
Topic: Secretary Salazar commented on the ongoing Cobell litigation.
"We are committed to trying to move that issue forward to a point where we can get it resolved because there are so many other issues that we need to work on together. And frankly until we get that issue resolved I think it is a distraction and a blemish on the other things that we have to do with respect to Indian country."
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Secretary of the Interior Ken Salazar addresses the National Association of Counties in Washington D.C.
Secretary of the Interior Ken Salazar addresses the National Association of Counties in Washington D.C.

subset: commoncrawl


text:
Bozeman is stepping up their triathlon game. The Bozeman Tritons Triathlon Club is not only a bunch of good racers, but a promoting machine. The Treasure State Triathlon and Headwaters Half Ironman are both based out of the Bozeman area.
The club's website has all the race information.
Base Camp East Fork
6 hours ago


text:
What You Should Know
|Star Rating
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|Less Than $5 Shipping
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|Rejuval Skin (2014 Editors Choice)
|Facial Toner
|IQ Derma
|Meaningful Beauty
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FantaSkin Line Reducing Cream is represented as a replenishing and moisturizing Botox alternative. FantaSkin Line Reducing Cream is designed to extend the life of skin cells and to repair damaged skin. The official product website for FantaSkin claims to use the latest scientific technology in its Line Reducing Cream, but it does not provide further explanation. FantaSkin Line Reducing Cream can be purchased online directly from the manufacturer or through various online retailers.
Product Details
FantaSkin Line Reducing Cream is a newly formulated facial treatment that utilizes advanced delivery technology. The key ingredients include Matrixyl and Hyaluronic Acid, which has been shown in scientific studies to bind up to 500 times its weight in water, helping the skin to retain and restore moisture. Use twice daily after FantaSkin Hydrating and/or FantaSkin Anti-Wrinkle Firming Serum, which are two other skin care products offered by this manufacturer.
FantaSkin includes the following ingredients:Water (Aqua), Proplyene Glycol, Sodium Hyaluronate (Hyaluronic Acid), Glycerin, Palmitoyl Pentapeptide-3 (Matrixyl), Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7, Squalane, Rosa Canina Flower Extract, Phenoxyethanol, Methylparaben, Ethylparaben, Butylparaben, Propylparaben, Isobutylparaben, Vitamin A Palmitate, Vitamin E Acetate, Fragrance (Parfum.)
The Good
- FantaSkin Line Reducing Cream contains powerful ingredients for treating lines and wrinkles including Hyaluronic Acid and Matrixyl.
- FantaSkin provides consumers with a complete list of ingredients for its Line Reducing Cream.
The Bad
- FantaSkin does not provide customer testimonials on its website for the Line Reducing Cream to substantiate their claims about its effectiveness.
- FantaSkin Line Reducing Cream must be purchased through the manufacturer's website to be able to take advantage of the company's fifteen day return policy.
- NuConcept Group is a company virtually unknown in the skincare industry and so consumers may prefer a well known brand of skin care and wrinkle treatment products.
The Bottom Line
FantaSkin Line Reducing Cream may temporarily improve skins appearance since it contains ingredients that have been proven in clinical trials to temporarily reduce the look of fine lines and wrinkles. Because FantaSkin Line Reducing Cream contains Hyaluronic Acid and Matrixyl, it is comparable to other products on the market that are much more expensive. One really good thing about FantaSkin Line Reducing Cream is that it is offered through the manufacturer for a low price of $39.95. Even if the company did not have a fifteen day return policy, at least consumers do not have to invest hundreds of dollars to give the product a try. It would be better if FantaSkin would provide customer testimonials as it does with its other products, or if close-up before and after photos were posted on its website. At the time of this review, we were unable to locate information pertaining to FantaSkin's clinical trials or any scientific research that proves the Line Reducing Cream was found to be effective.


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- Insulated Mug will keep beverages cold for hours
Ouya Devs Seeking Additional Funding Beyond the $4.9 Million from
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Welcome to Casa Sulo. Self catering accommodation in the Beiras region of Portugal
Private chalets with swimming pool for the perfect holiday in Portugal
Sue and Ken, authors of "The Eucalyptus Dance", (a book about Living in Portugal which is now available as a Kindle download from Amazon ) welcome you to Casa Sulo in the Beiras region of Central Portugal.
Casa Sulo is situated in the safe, idyllic, rural village of Alombada, surrounded by the refreshing fragrance of eucalyptus forests and with uninterrupted views across the mountains.
It is, however, within easy reach of the main arterial north/south and east/west roads with Aveiro and the Costa Nova and Barra beaches nearby.
The two self catering chalet apartments are equipped to a high standard, each sleeping up to five people; for larger families or groups they open up into a four bedroom villa.
Enjoy the private swimming pool in exclusive surroundings (see booking information for details).
Self catering breaks in beautiful surroundings.
The peace and tranquillity that is found here will hep you to relax and enjoy a perfect getaway from the rat-race. The knowledge that Ken and Sue have accumulated over their years in Portugal will help you to get the most out of your self catering accommodation holiday.


text:
Seagulls on Laxatives Prank Is an Instant, Messy Classic
Seagulls will eat just about anything they can get their beaks on. So when the scavengers spot a bunch of potato chips, there is little doubt they're going to dive in for a snack.
And when those potato chips have been spiked with laxatives, expect things to get messy. See just how much so in the video below.


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Robert McChesney scrapbooks, 1944-1975
McChesney, Robert, b. 1913 d. 2008
Active in Petaluma, Calif.
Collection size: 3 v. (on partial microfilm reel)
Collection Summary: Three scrapbooks containing exhibition catalogs and announcements, clippings, press releases, business agreements, and career and biographical information.
Biographical/Historical Note: Painter and mural painter, Petaluma, California.
Lent for microfilming 1975 by Robert McChesney.
How to Use this Collection
- Microfilm roll 878 available at Archives of American Art offices and through interlibrary loan.
- The Archives of American art does not own the original papers. Use is limited to the microfilm copy.
- For more information on using the Archives' resources, see the FAQ or Ask Us.


text:
Its offices are housed in a double-wide trailer surrounded by a block wall. Upon entering the compound, I noted a long shipping container ominously baking in the parking lot, the heavy doors shut and locked.
Kalvin Morwaeng, the director of Home Based Care in Bobonong, was in his stifling office, just back from the dentist. He flicked on the AC so I could write without sweat sopping my notebook.
My first question: How are the AfricaBikes working out?
"Actually, we're still trying to figure out how to use the bikes," Morwaeng, 31, replied, holding his jaw with his hand.
"Does that mean the bikes are not being used?" I asked flatly.
Morwaeng hesitated. "That's right."
I asked him where the bikes were.
"Safely locked in the container." He pointed toward the parking lot, and said a committee had been formed to look into the bikes; the committee met last November and would meet again sometime in the next few months.
I asked who would make the final decision. He said he would--after he heard from the bicycle committee. And after he wrote up a report about the bicycle committee's recommendations and presented it to the management committee, and after this committee approved the bicycle committee's assessment.
Morwaeng's tooth ached and my questions wearied him. I asked if I could speak to a few of the HIV/AIDS counselors.
Kgomotoo Sanoto told me, "For a little while I was riding the bike all the time." She counsels HIV-positive mothers about mother-to-child transmission, and talks to youth groups about both abstinence and the proper use of condoms.
"I would ride all over, house to house," Sanoto, 37, said laughing richly, throwing her heavy arms in both directions. She had an inextinguishable, deep-seated gaiety and faith. "Sometimes I could see more than 10 people in one day!"
Sanoto is a big woman and didn't look like a cyclist, but I was told that in the beginning she had been one of the most active riders. Sanoto has motivation. Her two sisters died of AIDS. She has five children of her own and is raising one dead sister's HIV-positive seven-year-old.
"But then bicycling became difficult."
Kgomotoo Sanoto seemed reluctant to explain. I had to prod.
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text:
933 Ocean
Hampton, NH
Bedford, NH Real Estate
Amherst, NH Real Estate
Milford, NH Real Estate
Goffstown, NH Real Estate
New Boston, NH Real Estate
Peterborough, NH Real Estate
Presented By:
Jacqui McCartin
BHHS - Verani Realty Bedford
© 2014 BHH Affiliates, LLC. An independently owned and operated franchisee of BHH Affiliates, LLC. Berkshire Hathaway HomeServices and the Berkshire Hathaway HomeServices symbol are registered service marks of HomeServices of America, Inc.® Equal Housing Opportunity. Information not verified or guaranteed.


text:
Boast Heavy Jersey PopoverSKU: #8259383
Product Information
- When that autumn crispness is in the air, don't go back to the boring basics to cut the cold. Keep your layered look fresh with the Boast™ Heavy Jersey Popover.
- Contrast collar and bold horizontal stripes for a classic rugby look.
- Premium long-staple Peruvian cotton is gassed and mercerized for a soft hand and lasting wear.
- Iconic Japanese maple leaf embroidery at chest.
- Heavyweight jersey rugby-styled pullover.
- Woven twill point collar and placket.
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- Ribbed cuffs and hem.
- 100% cotton.
- Machine wash and tumble dry.
- Imported.
- Measurements:
- Length: 28 in
- Product measurements were taken using size MD. Please note that measurements may vary by size.


text:
Hold down Control (PC) or Command (Mac) key + mouseclick to select more than one option
|Avg. Dinner Entrée
|Greater than $25
|$18.01 - $25
|$12.01 - $18
|$7.01 - $12
|Less than $7
Posted by Anonymous on 05/22/2014
I called 30 minutes before closing and politely asked if it was to late to place an order and they rudely said yeah then just hung up.
Posted by Karen on 12/01/2012
We are in the neighborhood and usually order for take out or delivery. The service is good. Not a long wait for delivery. You should try the House Special Chicken Steak with spinach. yum. It is one of our guilty pleasure stops in the neighborhood. I have never found the staff to be rude but don't expect bubbling enthusiasm.
Posted by Middleton Family on 07/08/2012
We stopped in for lunch during a day of sightseeing. The pizzas were large, and the sandwiches were good. Everyone in our party left satisfied and full!
Posted by Dyana on 06/17/2012
I gave it a few times but these people know rudeness. It's too bad because the food is pretty good.
Posted by Visitors from Hawaii on 04/26/2012
First visit we ate the Cheese steak hoagie added mushrooms & homemade chicken veg soup. Enjoyed all! Second visit we ate Vegetable pizza & Spaghetti w/meatballs. Again, enjoyed all! The pizza and spaghetti sauce was delish! Would eat there again.
Posted by Marie on 04/24/2012
After calling to order hoagies I was put on hold twice, and had to call back to pay via credit card & request a 6:30pm delivery time. Dealt with a truly rude & highly unskilled employee. By the time the food arrived the order was unsurprisingly incorrect and not fresh :(
Posted by megan on 02/10/2011
I live just around the corner, so this place usually satiates my late-night pizza fix. Chef Salad is hit or miss, chicken fingers and mozzarella sticks are well-worth it. Pizzas are small, but extremely fresh and inexpensive. The old cashier occassionally includes a free soda, and pizza toppings are prepared on premises. Everytime we order food, its always good (not great) but I find myself calling them again and again. Perhaps the crust is addictive?


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Narrow down the 37 results:Map View
We have a range of budget places to stay in Sitges from as low as £7 per night
Based on previous Sitges accommodation searches, the average starting price is £64
Want to splurge? At the top end in Sitges, we have 6 places to stay with prices starting at £110
x The average starting price for a place to stay in Sitges is £64 per night.
Av. Cami De Miralpeix, 12Excellent 90%
tomanov69 Great hotel,perfect location,friendly staff and a superb garden location for breakfast.Has a very "Spanish feel",but if you are looking for a modern hotel this isnt the place for you. I was on a tight budget so I booked a single room with shared bathroom which turned out to be perfect for my needs as I needed just a bed to sleep in for the night. Very central location for the bars,station, and a 5-10 min walk to the beach. Perfect !
Paseo Marítimo De Sitges 92-94Great 80%
Avinguda del Port d'Aiguadolc, 8Great 80%
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Posted at: 06/28/2013 4:48 PM
Updated at: 06/28/2013 5:05 PM
By: Berkeley Brean
We all trust that when we file our taxes, the state is going to process it and get whatever money we're owed back to us. So you can imagine the shock when one woman from Brighton called the state to find out the status of her filing and was told that they can't find it.
I-Team 10 was on to something when two other people – completely unrelated – also contacted the I-Team saying the same thing happened to them. They all have one thing in common -- they filed their taxes on paper, not online.
Nancy Uffindell knew something was wrong when she still didn't have her tax refund eight weeks after she filed it. " I filed on April 15 and I called on June 17 so it was just over eight weeks that I checked on my tax return."
Her hand written notes from a phone conversation with a rep from the state Department of Taxation and finance says "not found." Uffindell says it's because she filed her taxes on paper. "So they have a huge backlog as they told me on the phone and they just don't know how to handle it. I called Albany and a woman there told me there's a huge backlog of paper returns and to just wait."
So I-Team 10 contacted the state to find out what happened. We asked how they could lose a paper filing. Their response was they can't talk about individual cases but when a return is lost in the mail, they work directly with the taxpayer to promptly resolve the situation. The state says 95-percent of all tax refunds have gone out this year and 90-percent of all filings were done electronically.
Uffindel doesn't have a copy of her paper return but she has the receipt from the post office.
The zip code matches the zip code on the state's tax form. "I'm worried about people who are waiting for their tax return possible to buy medication or their groceries, just to get by day to day. And they're waiting just like I am. They probably think that they're tax refund is just slow in coming. That's what I thought."
The state says the fastest, easiest way to secure your tax refund is to file electronically. People with incomes under $57,000 can do it for free through the department's website. People who make under $51,000 can have their taxes filed for free by trained volunteers.
The state pays interest on any refund that they do not get back to the taxpayer by May 15. The refund owed to Uffindel is growing everyday.


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Last Updated: March 31, 2014 03:20pm ET
Colliers Taps Robinson as US President
SEATTLE�Craig M. Robinson brings Colliers �an unusual, and powerful combination of experience� that includes both corporate services and corporate real estate, Americas CEO Dylan Taylor tells GlobeSt.com.
You can now be notified via email if this story is updated by clicking on the "Follow this Story" link. You must be a registered member to take advantage of this "members only" benefit.


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Carlton Fellows celebrates 60th birthday with concert
James W. Wade III | 6/3/2014, 8:58 p.m.
When I first really paid attention to Fellows, he was singing along side one of Cleveland's best gospel groups The Evangelistic Team, with Leonard Burks, Bishop Redman, Michael Dotson and that great Lenny Champion. This group was by far one of Cleveland's best.
Fellows has been featured in The Gospel According to Broadway Production" solo performer with the Michael Terry Singers and The BBC Orchestra at the Hackney Theater in London England, Featured Soloist with the "Harlem Gospel Singers" 16-week European Tour, for four consecutive years.
Many have come in contact with him because of him conducting workshops throughout the country and in Europe educating singers and musicians in Praise and Worship.
Fellows was special guest clinician for the "Annual Krefeld Gospel Music Festival" in Krefeld, Germany. He has toured with "The Glories of Gospel Production" which depicts the history of Gospel Music from the early 1930's to present. The cast performs on college campuses throughout the state of Ohio, regionally, and abroad in Sweden, Lithuania and Norway.
Another great highlight was when Fellows was the featured soloist with 2000 voice Mass Choir of Gospel Music Workshop of American (GMWA) on the King James Label. He has released a solo album project entitled "Canaan Land,", Independently Distributed, and Total Praise Music.
While having the chance to play at a few churches, he still found time to things on a national level. He was guest solo performance with the Ohio Baptist General Convention (OBGC) Mass Choir project Entitled "It's God" in Dayton, Ohio, singing "Surrender" on the Aleho Label/Start Song Communications.
Also he was a featured soloist with the 300 voice men's chorus of the GMWA in Atlanta, Georgia, singing "Use Me Lord," on the Peperco Label and guest solo performance on the Atlanta Youth Chorale project, in Atlanta, Georgia, AYC, Inc.
During Black Music Month in 2014, The Call & Post is happy to salute Carlton Fellows and all he has accomplished. Through the eyes of Fellows, the musical groups and musicians, soloists all have so much talent in Cleveland.
"I love what I do and I feel so blessed to be celebrating my 60th birthday with all my friends and family," said Fellows.


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Uttarakhand, previously it was called Uttaranchal is one of the beautiful states of India which has all the aspects of tourism. Uttarakhand became a 27th state of India after separated from Uttar Pradesh at November 9, 2000. The state Uttarakhand is located in the northern part of India and borders Nepal on the east, Haryana to the west , Himachal Pradesh to the north west, Uttar Pradesh to the south and Tibet Autonomous Region on the north. When the state is separated from Uttar Pradesh, it named as Uttaranchal but in Jan 2007, the name of this Uttaranchal State was officially changed to Uttarakhand.
Dehradun is the provisional capital of the state which is one of the largest cities of the state Uttarakhand and the High Court is in Nainital. The population of Uttarakhand is around 8.50 million. There are two main regions in Uttarakhand, Garhwal and Kumaon and the people are generally called either Garhwali or Kumaoni according to their respective regions. Garhwali and Kumaoni are main dialects of Uttarakhand, but Jaunsari and Bhotiya dialects are also spoken by tribal communities. Hindi and English are the most languages used for conversations in urban regions.
Out of the total 51,125 km square geographical area the state of Uttarakhand or Uttaranchal has 93% mountains at which 64% is covered with forests. Remaining parts of forest is a part of Himalaya ranges and covered with glaciers or snow. And the 7% part of the state is plane area. All these beauty of nature made the state beautiful and full of tourism aspects. Jim Corbett National Park, Valley of Flowers National Park and Nanda Devi National Park are some adventurous and most visiting destinations of the state.
The state of Uttarakhand is a small state of India and has 13 districts which is grouped according to Garhwal and Kumaon divisions. Garahwal division includes 7 and Kumaon division includes 6 districts.
Copyright © 2012 by Uttarakhand Yatra. All rights reserved.


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July 29, 2015
Pump Patrol is back, but this time we're not just telling you where the cheapest gas is in the Brazos Valley but we're also taking a look at the price of diesel.
The lowest price we could find in College Station for diesel is $3.39 for a gallon.
That price was at the Wal-Mart on Briarcrest, the Shell on Villa Maria, as well as the Shell and Exxon on the corner of Rock Prairie and Wellborn.
As for the cheapest gas, it's down to $2.44 a gallon at the Wal-Mart on Briarcrest, but the state does have sub $2 a gallon a gas.
In Harlingen, you can find gas for just $1.98 a gallon.Closer to home in Austin, gas is selling for as little as $2.11 a gallon, and in Houston, you can find gas at $2.19 a gallon.
If you find a good gas price around the Brazos Valley, diesel or regular, email us at email@example.com.
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Guelph Mercury calls her "a revelation." Globe and Mail says Karyn Ellis is a "must-see" songstress and has "a magical way with song." Whether singing heartfelt tunes or leading raucous sing-a-longs, Karyn is engaging, funny and smart and her fine acoustic guitar-playing complements her sweet, dynamic voice. A modern folk darling, her thoughtful lyrics are about every-day wonders, beauty and hope. Calgary Herald gives four stars to Karyn's album, Even Though The Sky Was Falling, adding: "This is a woman with stories."
To date Karyn has independently released four albums – her most recent one More Than A Hero came out this winter – and has played over five hundred live appearances. [Read more…]


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LETTER: Graduates owed apology for wet, soggy ceremony
To the Editor:
Graduating high school is a milestone. Whether family travels from a mile away or miles across the country, it's a special time for families to share. The 2013 graduates of Lee County High School and their families now have another type of emotion to share about their graduation.
Lee County graduates, along with family, friends, the band, teachers and marshals, were subjected to heavy downpours during the entire ceremony on June 6. This was not an unexpected storm; rather, it was a well-forecasted one from as many as four days to four hours before the ceremony. The administration set up for an indoor ceremony yet still decided to hold the graduation outdoors. As predicted, the rain started to fall before 8 p.m. as the graduates were being led to their seats.
The older members of our family stayed home to watch the live-streaming video because they didn't want to be exposed to the weather. In the stands, we all tried to make the best of the situation. Comments from people around us were moving as quickly as the water off of umbrellas — [ranging] from hilarity to disappointment.
The administration made a mockery of this graduation ceremony and one totally discourteous to their students. Yes, if inside, there would only be four tickets per graduate, but still, an indoor ceremony would have been a respectful way to honor the students' achievements. (Southern Lee's administration decided to conduct their ceremony inside, communicated it by posting it on their website the day before and advised there would be extra seating in the cafeteria for those without tickets.)
As graduates' names were called, most people immediately left. After the last graduate's name was called and with a moat forming around the field, the speeches began. Those few remaining in the stands, the graduates, marshals, teachers and band members, most likely strained as we did to hear the speeches due to the competing sounds of the hard rain and wind gushes.
Maybe a different decision would have been made if those in charge would have personalized how the results of the decision would affect the graduates and their families. This Class of 2013 is owed an apology (and for some, the cost of ruined attire). There is at least one thing the administration can take from this: the graduates will always remember how wet and soggy they were at their graduation.
Michelle Morie


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Yesterday, Island/Def Jam honcho L.A. Reid hosted a few journalists in his office for a special preview of Mariah Carey's upcoming E=MC? album, tentatively due April 15. While Reid looked on, Mariah's A&R man and long-rumored beau Mark Sudack played 12 of the album's cuts from his laptop, often passionately (and adorably!) singing along. On the album, there was drama, there was death, there was disco. What follows is a track-by-track breakdown of our impressions of the album. Note that this isn't the final track sequence, that L.A. ticked off the producers list to us but it is by no means etched in stone and the tracks that we heard weren't always mastered.
One final note: so much of this album is sung in Mariah's chest voice. The vocal gymnastics and whistle notes, while there ('cause, duh, it's Mariah!), take a backseat to clear, purposeful singing, and Mariah sounds better for it. Oh yeah, Mimi's back.
1. "Migrate" (co-produced by Danja) ? After announcing itself with Mariah?s patented whistle notes, this club track gets to bangin? and it takes that task really seriously. It?s about as meta as a banger gets, with Mariah explaining during the chorus how her night goes: ?From the car to the club / We migrate / From the bar to the V.I.P. / We migrate.? And so it goes, from the party to the after party, from the after party to the hotel. There's a slight autotune effect on Mariah's voice on the last ?migrate? of each chorus, which I assume is to put her on equal ground with the man she shares the mic with here. T-Pain, mercifully shows up for just a guest verse ? this is not a full-blown duet. It?s a feisty track, with tough Storch-esque beats that Mariah?s bravado attempts to match: ?If you?re inked up thuggin?, that?s what I like,? she says. See, I always thought she went for the pretty boys. Already we?re learning stuff!
2. "Touch My Body" (co-produced with Christopher "Tricky" Stewart and The-Dream) ? There isn't much to say about this ultra-femme track that wasn?t said when it leaked. Hard to believe that that was only a little more than week ago ? in the time since, it?s become so ubiquitous that it?s kind of hard to imagine what radio was like before it. Even L.A. seemed taken aback by how quickly it has caught on ? he described the track's out-of-the-gate success as virtually accidental.
3. ?Last Kiss? (co-produced by Jermaine Dupri) ? One of the album?s many declarations of eternal love, this one is ?We Belong Together, Part 35.? It?s nice but extremely safe. One thing that?s very much in its favor are Mariah?s vocals, which are nimble as they are in ?We Belong Together? (she changes up her flow more times than I could count) and maybe more robust than they?ve sounded in over a decade. There?s a nice little duet at the end of this one between Mariah?s full chest voice and her higher register. Of course, if she didn?t show off that stellar natural resource, this wouldn?t be a Mariah Carey album.
4. ?Lovin? You Long Time? (co-produced by DJ Toomp) ? Pure and utter joy is this one, which is most reminiscent of the lovely Mimi outtake ?When I Feel It." Except this one's, like, 10 times better. The chorus of DeBarge?s ?Stay With Me? is the foundation of this track (as opposed to the verses, which provided the foundation for the single remix of Biggie?s ?One More Chance? and Ashanti?s ?Foolish,? among tracks). However, the sample sounds more weathered, and overall, the track comes off as a ?60s throwback rather than an ?80s one. One hundred percent feel-good and packing in a killer breakdown and conclusion that?s a wall of Mariah voices, this was the first song that felt like the work of unstoppable pop genius.
5. ?Thanx for Nothin?? (co-produced by Jermaine Durpri) ? A mid-tempo ballad that sports a beat rougher than anything Jermaine Dupri has laid down for Mariah and a guitar line not unlike Mimi?s ?So Lonely? (though this track is more sassy and less dour than that), ?Thanx? suggests that Mariah and Jermaine aren?t sentenced to live in the shadow of their former glory and can actually make relatively new sounds together. Lyrically, this break-up track is a cross between the self-deprecating ?Mine Again? (?I never knew enough about you, babe / And I guess I only have myself to blame?) and the streetwise posturing of ?Get Your Number? (?Seems like all I do is think about your pseudo-romance / While you?re somewhere burnin? diesel in the streets, havin? laughs?). Mariah packs in so many lyrics that she barely has time to sing them, and sort of just growls them. It?s not nearly as ridiculous as that description might make it sound.
6. ?That Chick? (co-produced by Stargate) ? Instant. Classic. An absolutely brilliant disco track that plays on Mariah?s strengths and sexiness without ever crossing the line into indulgence. It?s slick, it?s chic (and Chic, with its slap-you-on-the-ass bass line), it?s silly (?La da da a oooh wee-wee? goes the bit between the chorus and the verses) and it carries a killer middle 8 that?s as exhilarating as the one in Michael Jackson?s ?P.Y.T.? (you know, the best part of one of the best songs ever that goes, ?Don?t you know nowwwww / Is the perfect time???). Mariah makes references to 2Pac and Biggie, compares herself to ice cream and the lottery and maybe even references the long-lost track from the Charmbracelet sessions ?Touch the Sky.? Oh, and also she delivers the most her line of her career, complete with a 10-cent word: ?I brings that levity.? Maybe one day they?ll bottle the essence of Mariah, but until then, we have ?That Chick? and I seriously am counting down the days till I can hear this track again. This needs to be a single, like, now, and Mariah needs to dust off those ?Heartbreaker? remix roller skates for the video, pronto.
7. ?Cruise Control? (co-produced by Jermaine Dupri) ? Another J.D. track that deviates from what could have been a detrimental pattern, this is a reggae-lite extended car metaphor (?I need a caddy wit some cruise control,? belts Mariah). The chorus consists of her spelling out, ?C-R-U-I-S-E control? and the second verse finds Mariah adopting a Jamaican affect for kicks: ?When da door open I de gals pon de block / They be hop-on, to rob the clock / Me say no mam / Step up step up / Bottle broken / Tink I?m jokin?.? Seriously, she says that. Damien Marley gets a guest verse, and I have to say, his shtick is a little more convincing.
8. ?Side Effects? (co-produced by Scott Storch) ? You know how sometimes Southern rap almost has a heavy metal feel? Mariah and Storch exploit that by turning out a Southern-fried power ballad that?s a thinly veiled portrait of her time under Tommy Mottola?s reign (?Hell we built, and I dealt with it…Kept my tears inside ?cause I knew if I started, I?d keep cryin? for the rest of my life with you / I finally built up the strength to walk away / Don?t regret it…?). For someone as guarded as Mariah is publicly, it?s shockingly frank (she alludes to ?violent times?) and really naked (the titular side effects refer to the toll the relationship has taken on her: she?s ?still a little depressed inside? and ?still a little defensive thinkin? folks be tryin? to run my life?). This is another highlight, and having a rapper so associated with drugs (Jeezy) on a track called ?Side Effects? that isn?t about drugs at all, only makes things cleverer.
9. ?Love Story? (co-produced by Jermaine Dupri) ? Anther ode to endless love (?This ain?t no fairy tale or fiction / This is truly ours for eternity?), this ballad is more of the baby-making ilk. It?s like Prince-lite with a synthesized beat a la ?The Beautiful Ones,? but not as effects-laden (i.e. the beat doesn't have the backwards sound). The melody is reminiscent of Mimi?s ?Joyride,? and that should give you an indication of how sweet this track is.
10. ?OOC? (co-produced by Swizz Beatz) ? This one has a pummeling thump so pronounced, it?s somewhat surprising that it?s not the work of Stargate or Tricky. ?OOC? stands for ?out of control,? and while the track isn?t exactly wild, it?s a fun mix of The-Dream?s ?Ditch That N?? with a melody like Blu Cantrell?s ?Hit ?Em Up Style.? Besides the hypnotic refrain of ?Forever and ever,? the track is most notable for including the word motherf***er. As in, ?I know y?all motherf***ers feel like we / When you?re messin? with the one true lova / That makes you OOC.? Hardcore!
11. ?Bye Bye? (co-produced by Stargate) ? When Mariah first started promoting Mimi, she described ?We Belong Together? as a cross between ?Breakdown? and ?One Sweet Day.? That description is infinitely more appropriate for ?Bye Bye,? a song about death that?s ?for my people who just lost somebody,? ?for my people who lost their grandmothers? and seemingly for Mariah?s departed father, Alfred Roy (?You never got to see me back at No. 1?). It?s nice that Mariah?s on a confessional kick, although a track with the ?We Belong Together? sonic template and lyrics tailored appeal to everyone on such a basic level seems like too easy of a combination for someone as established as Mimi. This one?s like insurance ? in case nothing else is a hit, here?s a sure-shot. But ultimately, it turns out that the album is too good for that.
12. ?I Wish You Well? (co-produced by James Poyser) ? We were told that this was hot off the presses and a very rough version of the song, but even in its unpolished state, it was a stunner. A piano ballad that features Mariah, some gospel-tinged backing vocals, a piano and that?s it, this track is a throwback to the fan-favorite ?Vanishing? from her 1990 debut. Part feisty (?You can?t manipulate me like before?) and totally spiritual (Mariah name-checks a bible verse in the chorus, although I couldn?t catch exactly what it was, and she ends the song repeating, ?The Lord is my salvation / I will trust in him?), ?I Wish You Well? will have fans wetting themselves. It?s gorgeous and in its simplistic way, the type of risk that Mariah should take more often.
The risky moments on the album ("Lovin' You Long Time," "That Chick," "Side Effects" and "I Wish You Well") bode well for the future. Though E=MC? feels extremely safe, there's enough variation to signify some artistic growth. She?s cranking out hits and that?s fine because that?s what she's always done (hitmaking is her medium), but when she goes out of the Top 40 comfort zone, the album truly soars. Over 10 years after she first sang about it, it's only now that Mariah has worked up the courage to really spread her wings. The next question is: how high can they take her?


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Sony to adopt Google Honeycomb for first tablet effort
Sony CEO Sir Howard Stringer has revealed the tech giant is to officially launch its first tablet device later this summer in an attempt to rival Apple's market dominating iPad.
According to the Japanese newspaper, Nikkei, Stringer is reported to have revealed that Sony, a company which has yet to venture into the tablet market whilst its main competitors Samsung and LG jump in, will release its first iPad challenger this summer with the upcoming device set to run Google's tablet-centric Android 3.0 Honeycomb operating system.
Although little is currently known about the mooted Sony tablet, recent reported design leaks suggested the Sony device would forgo the typical look adopted by the iPad and its numerous challengers, instead opting for a curved form factor making the tablet appear to host an in-built stand feature and rolled newspaper aesthetic.
Reportedly being prepared for launch with the moniker the Sony S1, Stringer failed to comment on an official name or specs list for the upcoming device. With music streaming in the form of Music Unlimited and gaming from the PlayStation Suite at Sony's disposal, any upcoming tablet launches should not be short of high-end fillers.
Can Sony do what many other companies have failed to do and produce a true iPad competitor? Let us know what you think via the T3 Twitter and Facebook feeds.
Via: TechRadar


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With the impending closure of GameSpy online services on May 31, publisher 2K Games says players should expect a temporary outage of multiplayer modes for a number of its titles as it switches to a new online platform.
The original Borderlands, Civilization 3 and Civilization 4, along with expansions for both Sid Meier titles, will be affected by the transition to the Steamworks platform, 2K Games said in a release today. The publisher did not detail a timetable for the migration to Steam.
A handful of legacy PC titles, including Stronghold 2 and Close Combat First to Fight, will lose online functionality when GameSpy discontinues its online services and will not be transitioned to Steam, 2K Games added. A number of legacy titles across handheld and console platforms will also abandon online features, including NHL 2K10 on Wii and Sid Meier's Civilization Revolution on DS.
A complete list of titles affected by GameSpy's closure can be found in the press release after the break.
Borderlands: The Secret Armory of General Knoxx (02-19-10)
Beginning May 31, 2014, select legacy titles from the Borderlands® and Civilization® catalogs will temporarily go offline while service is transitioned to Steamworks. During the transition, players will experience interruption of several features, including online play, matchmaking and voiceover Internet protocol (VOIP) where applicable. Players will not experience interruptions to offline play.
The list of 2K titles currently slated for online migration includes:
Borderlands® (PC)
Civilization® III
Civilization® III: Conquests
Civilization® III: Play the World
Civilization® IV
Civilization® IV: Beyond the Sword
Civilization® IV: Colonization
Civilization® IV: Warlords
Starting May 31, Borderlands® PS3 and Civilization® Revolution PS3 will also go offline as a result of GameSpy Technology's online service termination. We are currently investigating the technical feasibility of transitioning those titles. Again, players will not experience interruptions to offline play for these titles. We will provide updates as they become available.
Additionally, 2K will discontinue online service functionality for a number of our legacy titles that use GameSpy. We apologize for the inconvenience this may cause.
2K titles losing online service as of May 31, 2014
Close Combat First to Fight (PC / Mac)
Jetfighter (PC)
Jetfighter V: Homeland Protector (PC)
Leadfoot (PC)
Rune (PC)
Stronghold 2 (PC)
Stronghold Legends (PC)
Top Spin (PS2 / PC)
Top Spin 2 (PC / DS)
Vietcong (PC)
Vietcong Demo (PC)
Vietcong Fist Alpha (PC)
Vietcong 2 (PC)
Vietcong 2 Demo (PC)
MLB Fantasy All-Stars (DS)
Sid Meier's Civilization Revolution (DS)
Major League Baseball 2K9 Fantasy All-Stars (DS)
NHL 2K10 (Wii)
NBA 2K10 (Wii)
Additional Nintendo DS and Wii titles may be impacted by the discontinuation of Nintendo Wi-Fi Connection Service on May 20, 2014. More details can be found at Nintendo's website.
Please note: We will update this article with the latest developments regarding service interruptions and future support for the Civilization and Borderlands titles listed above. To receive the latest updates about online service for these games, you may subscribe to this article by signing in to your 2K Support account and clicking the "Follow" link in the upper-right.


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Wow… remember my beautiful bracelet? The one the husband of the year got me? From BevaStyles?
Lisa, the extremely LURVLEY owner, appreciated my little post. She has generously offered a discount of 15%! Just use the code 'lurvlindsey'!
Of course, I've made a little shopping list, if you need some inspiration.
Please go check out her Etsy Shop!! She has some great vintage looks!


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Home Insurance
Are you covered?
Once you exchange contracts, your lender will insist that there is adequate buildings insurance cover in place and it is advisable to also take out contents insurance. This can be arranged to start at a date in the future, so that it's one less thing to think about.


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Tag: Matt Miller
Two Awards for Matt Miller
The Conservancy's Matt Miller has won two awards from the Outdoor Writers Association of America for his Cool Green Science blogging.
Should We Let the Wolves of Isle Royale Disappear?
The wolves of Isle Royale, one of the most-studied predator populations in the world, are disappearing. Should we save them? The answer may be more complicated than you think.
Traveling Naturalist: 5 Top Spots to See Yellowstone's Wildlife
Heading to America's first national park? Our blogger points you to the best spots to see Yellowstone's diverse wildlife, including creatures very, very large and those very, very small.
Book Week: 'Field Notes on Science and Nature'
Peer over the shoulder of noted field biologists in this engaging collection of essays on the science — and art — of note taking. And you might just become a better writer, and better scientist, in the process.
Traveling Naturalist: 5 Marvelous Marsupials to Spot in Queensland
Northern Tropical Queensland offers some of the best wildlife viewing anywhere, if you know where to look. Our blog gives you what you need to spot bizarre marsupials, including bandicoots, sugar gliders and kangaroos that live in trees.
The Latest Victim of Non-Native Cheatgrass: Golden Eagles
Cheatgrass keeps ecologists up at night. Its spread eliminates native plants, sage grouse and mule deer. New research adds golden eagles to that list.
Silence of the Rattlesnake Researchers: Snakes, Culture and Conservation
Snakes should fear us more than we fear them. In Vermont, timber rattlesnake research unexpectedly exposes humanity's tangled relationship with snakes. Can education shape a new future?
Snake Fungal Disease: The White-Nose Syndrome for Reptiles?
Researchers in Vermont were tracking the movements of timber rattlesnakes for conservation planning, but they also made an unexpected discovery: snake fungal disease. Could these lesions be deadly to snakes ? Could it affect snake populations the way white-nose syndrome affects bats?
Bison Bellows and Bones: Student-Scientists on the Prairie
Editor's Note: At the Samuel H. Ordway Prairie Preserve, students from Gustavus Adolphus College will soon be arriving to follow bison herds for the summer. This research program is not only taking an in-depth look at animal behavior, it's also providing information on how to best manage bison on fenced reserves. Today, we're running a previously published blog on last year's student researchers at Ordway Prairie.
I'm in the back seat of the vehicle as two female college students drive around, listen to music and—in their words—"look for guys."
Just another evening for students on break, right?
Well, not quite.
These students aren't driving to a party, nor are they cruising around downtown. There is no town. For that matter, there's no road.
We're bouncing around mixed grass prairie in South Dakota, the four-wheel-drive pick-up thumping over ruts and rocks. The vehicle's loaded with notebooks, GPS units and animal bones.
And the"guys"?
They're large, shaggy and prone to bellowing, wallowing and urinating on themselves.
They're bison bulls, the subject of these students' summer research project.
Michelle Hulke and Mary Joy Sun, entering their sophomore years at Gustavus Adolphus College in St. Peter, Minnesota, have spent day after day recording the bison bulls' fights, vocalizations and even tongue positions.
It's a research effort aimed at determining if bison bull behavior can be managed to produce more genetically diverse herds in fenced preserves and ranches, the type of environments where most bison herds now roam.
Hulke and Sun are the sixth set of Gustavus Adolphus students to research herd behavior at The Nature Conservancy's Samuel H. Ordway Prairie Preserve, a 7,800-acre grassland property near Leola. Each year, students at Gustavus Adolphus have the opportunity to participate in research projects following their freshmen year. The bison project has become one of the most popular.
Conservancy preserves and projects offer the perfect outdoor laboratories for undergraduate field research. The Conservancy employs mentors in the form of 550 scientists, and many projects already have a "science infrastructure"—the tools, established research protocols and housing and logistics that support fieldwork. Students learn not only science but also community relations, marketing and land management.
Preserves are places where budding scientists can develop their skills and contribute to meaningful conservation. It's a place where tomorrow's conservation leaders can gain field experience in spectacular settings.
In this case, that means living amongst bison herds.
The Traveling Naturalist: To the Bat Cave!
The Traveling Naturalist, our series featuring natural wonders and biological curiosities for the science-inclined wanderer.
What's the world's largest concentration of mammals? Many people guess that it's one of the great herds—the wildebeest in the Serengeti, or caribou in the Arctic.
But no: To see even more mammals, you have to look to the sky. More specifically, head to a bat cave in the Texas Hill Country, between now and the end of summer.
At caves around Texas, Mexican free-tailed bats emerge nightly by the millions. Yes, millions. The biggest? Bracken Cave, owned by the excellent conservation organization Bat Conservation International, with an estimated 15 million bats. That's a lot of critters.
These are maternal roosts: females come here to have young. Come fall, they migrate south to Mexico.
Bats emerge en masse from caves, and within minutes they stretch out to the horizon. At a glance it resembles nothing so much as a thick cloud of smoke, swaying in the breeze.
Where there are large congregations of animals, of course, there's also congregations of predators to take advantage of the bounty. Hovering outside the caves are often a variety of raptors, ready to snatch a wayward bat.
The Traveling Naturalist: Solid Gold in the Rockies
Introducing The Traveling Naturalist, a new series featuring natural wonders and biological curiosities for the science-inclined wanderer.
The Rocky Mountains in the spring are a botanist's delight, with many hills, mountain meadows and buttes awash in color. Wildflowers – many of them with interesting natural and human histories – can be easily found on your public lands. Some exist in bright but tiny cluster on alpine peaks while others cover meadows in a palette of seemingly solid color.
My favorite: the flower that paints many foothills bright gold throughout the West, arrowleaf balsamroot (Balsamorhiza sagittata).
Bristol Bay Blog, Part 3: A Future for Salmon?
Editor's Note: This is the final installment in a three-part blog series on the Conservancy's recent research at Bristol Bay, conducted to provide a risk assessment of the proposed Pebble Mine.
Can one of the world's largest mines be built in the headwaters of the world's largest salmon fishery without disrupting the ecosystem?
That's a question that generates a lot of controversy for the Bristol Bay watershed.
"There is a lot of vilification and name calling, but we wanted to go past that and get the data," says Dave Albert, director of conservation science for The Nature Conservancy in Alaska.
The Nature Conservancy in Alaska commissioned an ecological risk assessment to improve understanding of baseline conditions near the Pebble deposit as well as potential risks such a mine could pose to salmon.
The baseline studies showed that juvenile salmon are ubiquitous in headwaters near the Pebble deposit, including documentation of more than 100 miles of previously unknown salmon streams. It also documented the purity of the water. "This is about the cleanest water in the world," says Albert. "It's not distilled water, but it's pretty darn close."
The ecological risk assessment used a cutting-edge stream modeling system to investigate potential effects of large-scale mining facilities including open pit mines, a tailings impoundment and waste rock dumps on stream headwaters.
The model results indicate potential for significant negative effects, including up to 60 percent reduction in stream flows near the pit and contamination from waste rock that could exceed Alaska water quality standards. The giant waste rock piles generated by mining would require active pumping and water treatment; if these systems failed, the levels of copper in the river could rapidly exceed lethal levels for salmon.
According to the researchers: "Our study shows that while some of the flow and water quality changes brought about by mining could be ameliorated by ambitious mitigation measures and water management plans, severe water quality effects could result from even a brief failure of these systems."
The proposed mine dwarfs all other mines in Alaska combined; because the ore exists in low concentrations preliminary designs developed by the mining company show the mine covering twenty square miles with a massive tailings impoundment. From preliminary information released by the company, this tailings pond would require perpetual mediation in an area known for active earthquakes.
"We haven't seen a detailed mine and water management plan, but it would be difficult to envision a project of this scale that does not require active management, basically forever, to avoid contamination," says Albert.
Bristol Bay Blog, Part 2: The Salmon Portfolio
Editor's Note: This is the second in a three-part blog on the Conservancy's recent research at Bristol Bay, conducted to provide a risk assessment of the proposed Pebble Mine. Yesterday's blog covered background and research methods.
This is a land shaped by salmon—in ways large and small, apparent and obscure. Fly over Bristol Bay, and the impact of salmon is everywhere, in literally every living thing.
"Salmon built much of the Alaska we see today," says Dave Albert, director of conservation science for The Nature Conservancy in Alaska. "At historic levels of abundance, salmon are a fundamental driver of any ecological system they inhabit. They're in the bears and the eagles and the trees and the berries and the people."
Unlike at most salmon-producing regions of the world, at Bristol Bay scientists can still study a full and functioning salmon ecosystem. The sockeye salmon populations in this region are the most productive in the world. These stocks have contributed an estimated 51 percent of all global sockeye production since 1970. And there are four other salmon species found here as well.
The life history of salmon is well documented. Salmon are hatched in freshwater streams. After growing large enough to make the lengthy journey, they swim to the sea. In the ocean, they grow large while eating smaller fish.
After two to four years, they return to the stream of their birth, lay eggs that will become a new generation of salmon, and die. Their bodies become food for bears and a whole host of other scavengers. Bits of salmon flesh are gobbled by rainbow trout, char and other fish. They nourish algae in the water that provides food for aquatic insects that in turn become food for the next generation of salmon offspring.
"Salmon are in essence a nutrient-delivery system," says Albert. "They bring nutrients from the rich marine environment to the nutrient-poor rivers and lakes, generation after generation."
Bristol Bay Blog, Part 1: Understanding Remote, Wild Waters
No fishing hyperbole: We caught something every other cast. At least.
Huge king salmon spawned in the river, but these were not the fish we were seeking. It was the fish following the king salmon. A host of species lined up downstream as the kings spawned, picking off eggs as they drifted past. We cast little beads that imitated the eggs and bam! Fish on!
Maybe it was a grayling or a large rainbow trout or a char. It didn't matter: it was the greatest fishing of my life.
That was my first afternoon in the Bristol Bay watershed. The ensuing days there seemed like a parade of wonders: volcanic mountaintops, bears roaming lakeshores, hooking silver salmon in the rain, more rainbow trout and grayling and char.
Here's the thing: We weren't even there for the main event—the largest sockeye salmon runs on earth that taken together produce more sockeye salmon than the rest of the world. Combined.
Just last evening, we baked one of our Bristol Bay silver salmon fillets, and the memories came rushing back—memories of one of my finest adventures in a life filled with the pursuit of outdoor experiences around the globe.
And so I understand well the passion, the emotion, people feel for this place, especially when a gigantic mine is proposed right in the midst of it.
The Bristol Bay watershed is located in southwestern Alaska, a mind-bogglingly wild expanse of rivers and streams that covers 58,000 square miles. It has always been best known for its salmon population and the subsistence, commercial and recreational fisheries it supports.
Lately, though, Bristol Bay has received even broader attention, with the proposed mine most commonly known as the Pebble Mine. As it happens, Bristol Bay also sits atop the largest copper and gold deposit on earth. By most estimates, Pebble Mine would be the largest copper mine in North America and one of the largest in the world.
Enjoy Osprey Cam Live!
The Ospreys Are Back!
Live views, 24/7, of an Alabama osprey nest. Record your observations and ask our ecologist about what you're seeing.
What is Cool Green Science?
noun 1. Blog where Nature Conservancy scientists, science writers and external experts discuss and debate how conservation can meet the challenges of a 9 billion + planet.
2. Blog with astonishing photos, videos and dispatches of Nature Conservancy science in the field.
3. Home of Weird Nature, The Cooler, Quick Study, Traveling Naturalist and other amazing features.
Cool Green Science is edited by Matt Miller, the Conservancy's deputy director for science communications, and managed by Lisa Feldkamp, an American Council of Learned Societies fellow with the TNC science communications team. Email us your feedback.
Innovative Science
Call for Inclusive Conservation
Join Heather Tallis in a call to increase the diversity of voices and values in the conservation debate.
Appalachian Energy Development
Where will energy development hit hardest? And where can conservationists make a difference?
Not a sci-fi movie. A true story of nanotechnology & clean water.
On the Wild Side
Bird is the Word
Latest Tweets from @nature_brains
- Birds are taking over the world, one GoPro at a time http://t.co/cI1qvVpUEq on @audubonsociety
- Mangroves: Indonesia's best hope for slowing climate change: http://t.co/2DgtaLltJZ via @CIFOR
- Gadfly, chessmaster, Shiva incarnate, box burner: What would you say about #PeterKareiva?: http://t.co/3Srmdyko8i https://t.co/rskWx7dkMJ
- No time? Links between environmental degradation & time poverty: http://t.co/caijWZxEPR #conservation #time http://t.co/tqosNDSZJ3
- Swamp power: Farming in the world's wetlands to help stop climate change: http://t.co/EjFoQzKTUQ via @guardianeco https://t.co/gApsGcmyql
Blogroll: Conservation and Science
- 10,000 Birds
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- Yale Environment 360


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What You Should Know
|Star Rating
|2 or More Patented Ingredients
|Less Than $5 Shipping
|Trial Offer
|Rejuval Skin (2014 Editors Choice)
|Facial Toner
|IQ Derma
|Meaningful Beauty
Rederma Renewing Wrinkle Serum is one of many anti-aging skin care products available in the market place. Rederma is advertised as an "Advanced NeuroPeptide based Free-Radical Scavenger and Fine Line Wrinkle Reducer". NeuroPeptides occur naturally in the body and are abundant in the skin of children. NeuroPeptides may play a key role in maintaining youthful skin. Rederma promises to improve the skin's resilience and tone to reveal a more youthful appearance. Renewing the skin's texture and coloring as well as minimizing fine lines and wrinkles is important to consumers in the market for anti-aging products. The official website boasts that the formula is "hand made by scientists" in "small batches" and is only available in small quantities.
Product Details
Rederma Renewing Wrinkle Serum contains ingredients such as SNAP 8, Syn-Col, Silk Peptide Complex and Hyaluron (also called hyaluronic acid or hyaluronate) which is a natural moisturizer capable of absorbing up to 1000% more moisture into the skin. The official website claims that in as little as two weeks, you can be "wrinkle free". The package directions suggest using the product twice daily, both AM and PM, working with both hands moving in upward strokes toward the ears for enhanced "lifting" results. The directions also recommend using an SPF sun block after the product is absorbed into the skin.
The Good
- Rederma Renewing Wrinkle Serum is available for purchase at many online retail sites.
- The official website has posted a few positive customer testimonials for review.
The Bad
- The manufacturer's sales model is confusing, offering bulk discount purchases and then stating that the product is only manufactured in small batches.
- The official website only allows purchases to be made through Paypal or by money order which limits its customer base for online purchases.
- No before and after photos are provided to substantiate the claimed 2 week "wrinkle free" results.
The Bottom Line
Rederma Renewing Wrinkle Serum seems to be the only product offered by this manufacturer on the official website. There are no clinical studies and no before and after photos to back up the claims. There is not a customer service phone number or address and nothing published about the manufacturer on the official website. Although there is an offer to purchase the products on the official website, there is no link to actually make a purchase. However other online retailers make the product available. Shopping for anti-aging products can be confusing and there is definitely no shortage of anti-aging products in the market place. For a company like Rederma to make their product stand out above the rest, they must publish information about the company's credentials, post the clinical studies on their official website, and also list contact information so consumers can ask questions or resolve any transaction errors. Otherwise, the company looks like a "fly by night" company that will make consumers want to run in the opposite direction, right into the arms of its competitors.


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Employee satisfaction surveys are hot. Many Fortune 500 companies now conduct them. But both research and my own discussions with management
suggest that employee surveys often fail
to deliver on their promise.
Conducting an employee survey isn't
easy. Many companies perform these surveys by throwing questions together haphazardly and hoping something great will
happen. Often, this approach not only fails
to work but can alienate employees.
Before constructing an employee sur-vey, company leaders should be clear onits purpose and committed to acting onits results. Management often fails to ap-preciate how the information in an em-ployee survey links to profit. Because anemployee survey is an investment in timeand money, it requires a return-on-invest-ment analysis to measure its success.
If HR is to become a strategic partner,
the data it collects must influence the
company's business planning cycle. To
do this, HR/benefits professionals need to
relate what they've learned from employee
satisfaction surveys to profit drivers like
organizational commitment, job satisfaction, morale, productivity, absenteeism


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Professor of Mechanical Engineering
Phone: 860.768.5554
Fax: 860.768.5043
United Technologies Hall 302 A
Research Areas
Heat, Mass and Momentum Transfer
Thermal Systems Modeling and Simulation
Numerical Modeling and Inverse Methods
Parameter Estimation Optimization
Energy Analysis and Management
Energy Conversion and Storage
HVAC-R Equipment and Systems
Ground Source Heat Pumps
Solar Energy Utilization
Energy Engineering and Sustainable Design
U.S. Regulatory Commission awards $121,560 for the use of physical and computer models to enhance learning for nuclear power plant design and operation. National Aeronautics & Space Administration awards $6,000 for space suite life support. Read more


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Watch The Recovery Month PSA
September is National Recovery Month
National Recovery Month promotes the societal benefits of prevention, treatment and recovery for mental and substance use disorders, celebrates people in recovery, recognizes the contributions of treatment and service providers and promotes the message that recovery is possible. Recovery Month spreads the positive message that behavioral health is essential to overall health, that prevention works, treatment is effective and people can and do recover.
Fairbanks supports National Recovery Month and we hope you will join us. In honor of National Recovery Month we are sponsoring a few different activities and participating in many others within the Indianapolis community.
Wednesday, September 3: Wear Purple for Recovery Month - be sure to wear your purple loud and proud in honor of National Recovery Month. Stickers will be available at the Fresh Start Cafe in the Fairbanks Recovery Center to let people know why you're wearing purple.
Saturday, September 6: Recovery Ride and Recovery Cookout Celebration: (10 a.m. - 3 p.m.) A free police escorted motorcycle ride around I-465 in Marion County leaving from South Side Harley Davidson in Indianapolis and ending at Riverside Park shelter 6 for a free cookout/rally celebration of recovery. Get more details for this event, sponsored by Indiana Addictions Issues Coalition.
Saturday, September 13: Hawk Walk First Steps For Recovery - Join in for a 3k walk or 5k & 10k timed race. Registration is now open and will be available the day of the even. For more information visit the 24 Group website.
Saturday, September 27: Annual Fairbanks Alumni Association Golf Outing at Ironwood Golf Club 9 a.m. start.
Other community events can be found by visiting the National Recovery Month website.


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Geek Speak
Geek Speak is where the world of Geekdom comes alive.
Posts filtered on Tag
Don't want a Batfleck? Who would you rather see as the new Batman?
By now you've heard that Oscar-winner Ben Affleck will play Batman in the 2015 "Man of Steel" sequel. Yeah, let that sink in a moment. Still breathing? Good. It's a polarizing casting to say the least. Personally, I'm much more befuddled than outraged. Given Henry Cavill's under-the-radar status to play Superman, I'd hoped Warner Bros. […] [Read More]


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Outdoor patios may be a breath of fresh air for area restaurants and bars.
Under the recent Ohio Issue 5, smoking is banned indoors at all public places and places of employment -- but outdoors is another story.
Some restaurants had plans to add patios long before Issue 5 took effect, but the smoker-friendly environments could very well be bringing back some customers who had been deterred by the smoking ban.
The Fireside Lounge, Cameo Pizza and Markley's are among many local restaurants that now feature patios.
According to David Bier, owner of the Fireside Lounge, his establishment made plans to add a patio when the smoking ban went into effect.
These outdoor patios are being enjoyed by smokers and non-smokers alike.
"It's great. That's where everybody goes on sunny days," said Scotty Himmelein, manager of the Fireside Lounge.
On Nov. 5, 2006, Ohio voters passed Issue 5, a constitutional amendment banning smoking in all enclosed public places and places of employment as of Dec. 5, 2006. Active enforcement of the ban began on May 3.
Alexandra Houser, director of public relations for the American Cancer Society of Ohio, pointed out 2.2 million Ohio voters supported a smoke-free workplace. Outdoor patios may help establishments with patrons who smoke ease into the smoking ban, she said.
"It's less of a health hazard for sure," Houser said of secondhand smoke that becomes diffused on the outdoor patios.
Kristopher Weiss, spokesman for the Ohio Department of Health, said outdoor patios that allow smoking are completely legal under the new Ohio laws.
"There has to be a free flow of air," Weiss explained. "Basically the standard is that more than 50 percent of the enclosure had to be open to the air."
Patios must also be separated from the indoor portion of the establishment.
"People who are looking to do an outdoor patio should check with their local health department to review the requirements," Weiss suggested.
Mary Dennis, Director of the Community Health Division of the Erie County Health Department has already consulted with local establishments interested in adding an outdoor patio for smokers.
"I'm more than happy to consult with (businesses) about their plans," Dennis said.
While patrons can legally smoke on outdoor patios, each restaurant or bar will have its own policy.
For additional specifications of the law or more information on the Ohio smoking ban, visit smokefreeohio.org.


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RUMOR is Las Vegas' newest all-suite boutique hotel. Enjoy a cocktail at the bar or tapas at Addiction Restaurant. Stroll out to the pool and unwind in a palm-covered hammock or simply relax in your brand new suite.
This modern chic boutique hotel is located across the street from the Hard Rock Hotel and Casino, and whether your Las Vegas trip is for business or pleasure you'll enjoy exceptional accommodations close to the Las Vegas Strip action, McCarran International Airport, and the Las Vegas Convention Center.


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About FDA
Drug Safety Oversight Board Meeting, September 16, 2010
Public Summary
The Executive Director updated the Drug Safety Oversight Board (DSB or Board) on Drug Safety Communications posted and in development since the July 15, 2010 meeting. The following is a list of the posted risk communications:
Drug Safety Communications Posted since the July 15, 2010 DSB meeting:
- July 15, 2010: Ongoing safety review of the angiotensin receptor blockers and cancer: FDA issued a DSC to inform health care professionals and the public that it is conducting a review of the class of medications known as angiotensin receptor blockers (ARBs) after a recently published study suggested they may be associated with a small increased risk of cancer.
- July 29, 2010: Eosinophilic pneumonia associated with the use of Cubicin (daptomycin): FDA issued a DSC to inform health care professionals and patients about the potential for developing eosinophilic pneumonia during treatment with Cubicin (daptomycin), an intravenous antibacterial drug.
- July 29, 2010: Ongoing safety review of Evamist (estradiol transdermal spray) and unintended exposure of children and pets to topical estrogen: FDA issued a DSC to inform health care professionals and the public that it is reviewing reports of adverse effects from Evamist in children who may have been unintentionally exposed to the drug through skin contact with women using this product. FDA has also received reports of inadvertent exposure in pets.
- August 2, 2010: Serious medication errors from intravenous administration of nimodipine oral capsules: FDA issued a DSC to alert health care professionals that nimodipine capsules should be given only by mouth or through a feeding tube (nasogastric tube). This oral medication should never be given by intravenous administration. FDA continues to receive reports of intravenous nimodipine use, with serious, sometimes fatal, consequences. Intravenous injection of nimodipine can result in death, cardiac arrest, severe falls in blood pressure, and other heart-related complications.
- August 12, 2010: Aseptic meningitis associated with use of Lamictal (lamotrigine): FDA issued a DSC to inform health care professionals and the public that Lamictal (lamotrigine), a medication commonly used for seizures in children two years and older, and bipolar disorder in adults, can cause aseptic meningitis. FDA is revising the Warnings and Precautions section of the drug label and the patient Medication Guide to include information about this risk.
- August 20, 2010: Ongoing Safety Review of Stalevo and possible increased cardiovascular risk: FDA issued a DSC to inform health care professionals and the public that it is evaluating clinical trial data that suggest patients taking Stalevo (a combination of carbidopa/levodopa and entacapone) may be at an increased risk for cardiovascular events (heart attack, stroke, and cardiovascular death) compared to those taking carbidopa/levodopa (sold as the combination product, Sinemet).
- September 1, 2010: Increased risk of death with Tygacil (tigecycline) compared to other antibiotics used to treat similar infections: FDA issues a DSC informing health care professionals and the public about a recent pooled analysis of 13 trials with patients given Tygacil for approved and unapproved indications. The analysis showed an increase in all-cause mortality in patients taking tigecycline compared to patients taking comparator drugs with a risk difference of 0.6 (95% CI 0.1 - 1.2). The cause of the excess death in uncertain but is most likely related to progression of infection in patients with sever infections. The greatest risk was seen in patients with ventilator-associated pneumonia, an unapproved use.
- September 9, 2010: Gadolinium-based contrast agents and class labeling changes: FDA issued a DSC to inform health care professionals and the public about required label changes for gadolinium-based contrast agents (GBCAs) to minimize the risk of nephrogenic systemic fibrosis (NSF), a rare, but serious, condition associated with the use of GBCAs in certain patients with kidney dysfunction. The label changes include contraindicating Magnevist, Optimark, and Omniscan in patients with acute kidney injury or chronic kidney disease with a GFR <30 mL/min.
- September 15, 2010: New dosing recommendations to prevent potential Valcyte (valganciclovir) overdose in pediatric transplant patients: FDA issued a DSC to inform health care professionals and the public about new pediatric dosing recommendations for Valcyte (valganciclovir hydrochloride) oral tablets and solution. The change is being made to prevent potential overdosing with valganciclovir in children with low body weight, low body surface area, and below normal serum creatinine.
The DSB discussed three topics:
1. Update on Risk Evaluation and Mitigation Strategies (REMS)
2. Stalevo and cardiovascular safety
3. Update on the Safe Use Initiative
The views expressed by non-CDER employees are those of the individual and not necessarily the opinion of their respective government agency.
Update on Risk Evaluation and Mitigation Strategies (REMS)
A REMS is a required risk management plan that uses risk minimization strategies beyond professional labeling. FDA can require a REMS if they believe it is necessary to ensure that the benefits of a drug outweigh its risks.
FDA was given the authority to require REMS in March 2008 under the Food and Drug Administration Amendments Act. The Office of Surveillance and Epidemiology (OSE) presented the DSB with an update on CDER's experience with REMS during the past 30 months.
The Board discussed the following:
- A brief overview of the REMS program
- The challenges associated with implementing REMS
- The importance of developing REMS that effectively minimize potential risks of using a drug while imposing the least burden
- The challenges associated with review of REMS assessments and development of assessment surveys
- Metrics for REMS assessment and the challenge of determining metrics for success when baseline data are difficult to obtain or are not available
- The challenge of reducing the burden of REMS on the health care system
Stalevo and Cardiovascular Safety
Stalevo is a triple combination product with entacapone, carbidopa, and levodopa approved in 1999 for the treatment of Parkinson's disease (PD). Entacapone lacks an anti-Parkinson's effect on its own, but increases the peripheral and brain levodopa availability. Levodopa relieves some of the symptoms of Parkinson's disease.
On August 20, 2010, FDA posted a Drug Safety Communication (DSC) to inform healthcare professionals and the public about a possible increased risk of cardiovascular (CV) adverse events with the use of Stalevo. FDA Drug Safety Communication: Ongoing Safety Review of Stalevo and possible increased cardiovascular risk.
Board discussed the DSC and any impact it may have had on healthcare professionals and the public.
The Federal Partners with hospitals and clinics provided Stalevo usage patterns including any information about CV adverse events in their patients using Stalevo. The Board invited a guest expert in cardiovascular studies, Dr. Michael Lauer, from the National Heart Lung and Blood Institute (NHLBI) at the National Institutes of Health (NIH). Dr. Lauer provided a research perspective on the use of Stalevo and the risk of CV adverse events.
The Board discussed the following:
- A brief overview of the use of Stalevo and its components: entacapone, carbidopa, and levodopa in patients with PD
- A brief overview of the mechanism of action of entacapone, carbidopa, and levodopa in relieving symptoms of PD
- The current drug label for Stalevo
- Clinical data from the STRIDE-PD randomized trial and epidemiologic data reporting an association of CV risk with Stalevo
- A meta-analysis of 15 clinical trials looking at CV risk with use of Stalevo or its entacapone component.
- The challenges associated with interpreting the meta-analysis given much of the potential signal for CV risk comes from the STRIDE-PD trial.
- The August 20, 2010 DSC on Stalevo and CV risk and its main messages
- Possible approaches to further evaluating the potential signal for CV risk with Stalevo
Update on the Safe Use Initiative
Safe Use is a FDA initiative to reduce risks from prescription and OTC medications; promote drug safety outside of the usual regulatory authorities, such as REMS or labeling; and form collaborations with health care stakeholders to address preventable harm from a broader perspective.
The priorities for Safe Use are issues that are associated with preventable harm, have an impact on public health, are amenable to a collaborative approach to harm reduction, are measureable, and complement ongoing regulatory activities.
The Board discussed the following:
- A brief overview of the Safe Use program
- Current issues being address by the Safe Use team
- The challenges associated with developing collaborative partnerships
- Future plans for the Safe Use initiative