text:
Roots Audio is an audio company run by Gabriel R Lamorie III. Gabe has switched gears and is currently a student for audio programming, pursuing his BSc in computer programming.
After years on standby, Gabe has come to the conclusion that there is currently no way to produce enough intellectual content to occupy readers' pursuit of knowledge. So, let it be known that Roots Audio, while still providing the usual audio services, will now be Gabe's outlet for his experiences in the Bay Area, CA. These experiences will consist of:
- Educational
- Professional
- Awkward Stuff
- Bay Area Gems
- Situations
While these may or may not be of interest, navigating to our 'Home Grown' column may be of some use! When available, readers will discover aspiring audio engineers, programming achievements, music events, and all other local happenings that Gabe crosses paths with.
Now go. And don't stop.


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Looking forward to finding out what Australia and New Zealand has to offer!!!!
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subset: commoncrawl


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Posted at: 04/24/2013 12:27 PM
Updated at: 04/24/2013 5:30 PM
By: Kumi Tucker
SCHENECTADY – Tammy McCormack's cousin was thinking she can't imagine this one person can affect so many lives and hurt so many people, as she watched Brice Rivenburgh in Schenectady County Court.
28-year-old Brice Rivenburgh was brought into court before Judge Karen Drago to answer charges including murder, rape, arson and burglary, and family members of the victims of the double homicide were there for his arraignment.
"It was awful," said Doreen Pitsas, Tammy McCormack's cousin. "I hope that no family has to experience what we're going through today."
The bodies of 52-year-old Tammy McCormack and her daughter Jessica were found in their bedrooms in their Inner Drive home in Rotterdam on April 10.
"Jessica was great. She was fun. She had a big heart. Tammy was wonderful, loved her family. Took good care of her family. Would do anything for anyone," said Pitsas.
Authorities say Rivenburgh was Jessica's on-again, off-again boyfriend.
Prosecutors say Rivenburgh raped and killed Jessica, murdered her mother, and stole a television. He is accused of going back to the home two more times after the murders, once for food, and then to set a fire and try to cover up his crimes.
Prosecutors say Rivenburgh even sent text messages to Jessica after he knew she was already dead.
Doreen Pitsas wants to thank the community for its support during a terrible time.
"I can't even begin to tell you, between phone calls and cards and food and flowers and donations, Rotterdam is wonderful."
Rivenburgh pleaded not guilty to all charges and is due back in court July 8.


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Messi had struggled for fitness in the build-up and was an unused substitute at the Nou Camp for the 3-0 second-leg defeat to Bayern Munich, which sealed a crushing 7-0 aggregate loss.
Laudrup graced the Nou Camp as a player between 1989 and 1994, winning the European Cup in 1992, and feels the Catalan club have become too dependent on the Argentina forward.
"When they saw Messi was on the bench nobody thought it was possible to see a comeback (after a 4-0 first-leg defeat)," the Dane said.
"They have a great team but it's a little bit worrying that everything is related to the ability of Messi. Even if he is the best player in the world, it can be a problem."
Bayern advanced to a Wembley final against Bundesliga rivals Borussia Dortmund, who saw off Real Madrid in the other semi-final, but Laudrup thinks it is too early to suggest the German teams' success heralds a new era for European club football.
He added: "I know this is the year of the German sides and there are a lot of questions.
"Is it the end of Spanish football dominating? Are English sides struggling? We have to look to next year for the answers.
"If Borussia Dortmund and Bayern Munich are in the final in 12 months' time and there are no English sides in the quarter-finals then we might have a new trend."


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7:03 am
Fri February 14, 2014
L.A.'s Metro Red Line Plays Cupid
By editor
Originally published on Fri February 14, 2014 7:18 am
Good morning, I'm Renee Montagne.
Lonely hearts in Los Angeles could meet sweethearts underground this Valentine's Day. The City of Angels plays Cupid, hosting speed dating sessions aboard its Metro Red Line. Interested passengers can wear pink wristbands and board cars adorned with red hearts. After two minutes, they're free to find a new seatmate. Or, if the mini-date really goes off the rails, they can get off and wait for the next train.
It's MORNING EDITION. Transcript provided by NPR, Copyright NPR.


text:
Shirley Christie
Canadian Research In Motion launched two of its latest handsets, BlackBerry Bold 9790 and BlackBerry Curve 9380, in Jakarta on Tuesday night, as a token of appreciation for the increasing number of BlackBerry service users in Indonesia.
"These two new products will be available in the market starting next week," said RIM's co-chief executive officer, Jim Balsillie, whose visit to the country was kept private until the launch event on Tuesday night.
He said he was surprised to see the significant growth of BlackBerry in Indonesia.
The subscribers of "BlackBerry Internet Service (BIS)," a service provisioned through a mobile phone service provider, has multiplied by a factor of 10 in the last two years, while around 85 percent of Blackberry users in Indonesia have activated BlackBerry Messenger (BBM) service.
On the sidelines of the event, RIM's regional managing director for Asia Pacific, Gregory Wade, said Reseach firm IDC estimated that by the end of this year, Blackberry's market share in Indonesia would be 42 percent.
According to IDC data, the annual shipment of BlackBerry products to Indonesia would be close to 4 million by end of this year, he told the Jakarta Globe.
"By 2015, the annual shipment of BlackBerry smartphones to Indonesia would reach 9.7 million, in front of Android and Windows mobile smartphones. We are very optimistic about it."
Wade said the great thing about Southeast Asia's largest market was the large base of growing middle class, which is estimated to reach 150 million people by 2015. Indonesia's economy, meanwhile, was estimated to grow 6.5 percent this year, due to strong domestic spending and investment.
"The Mobile penetration rate is still fairly low and we have already become the majority player, so we welcome this," he said.
To achieve this expansion goal, he said distribution of products through mobile carriers, distributors, retailers, and application development would be crucial components.
The Canadian company would open the second BlackBerry lifestyle store in Southeast Asia at Kelapa Gading Mall in North Jakarta on Wednesday, to enhance its "retail look and feel."
"[Jim Balsillie] is so excited about Indonesia. He is enthusiastic about the entrepreneurial drive, the innovator and the apps development here," Wade said.
"Also, [Balsillie] is impressed with Indonesia's leadership in terms of applications and social networking. He believes that Indonesia is one of the best places in the world for social networking application development," he added.
Beside launching its latest products on Tuesday, RIM also introduced its newly appointed country director for RIM Indonesia, Rohilesh Singh.
He will be responsible for RIM's operations in Indonesia. Andrew Cobham, who was introduced as RIM Indonesia's president director last year, was said to have taken another role in the company.


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WEEK 1, June 30
It begins. Theme song. Tears of joy. Summer is over? I can't take it. There's cake, there's fondue, there are Stanley's favorites… dumplings. I am f**king starving, so this isn't helping. Corporate is sponsoring a weight loss contest in exchange for 3 vacation days. Stanley wants to take the leftovers home to his wife (where, hopefully, something will need to be toasted), while Creed offers to bring the leftovers to his shelter. Dwight sprays everything with Dust-Off, rendering it unedible and yet ironically dust-free.
Let us now take a moment to remember that Angela and Andy are engaged. And, more importantly, they've never seen each other naked. The gang heads down to the wearhouse for weigh in time with Darryl. Dwight encourages them all to quickly eat an eclair to up their starting weight. I shall finish this paragraph with the following epithet: "Hold it in your mouth if you can't swallow."
Breaking news in the world of JAM: Pam is leaving Scranton! To go to school in New York. Breaking News Part 2: Kevin is still retarded. At least according to Holly (and Angela.) Stanley has decided to lose weight on his own in order to get back to his Black Panther Chic days. Michael's still crushing on Holly in a big way, and Dwight hammers an apple into the vending machine. All is normal at Dunder Mifflin.
Oscar and Holly have a quick chat, where her "I'm a Lesbian" joke sort of bombs in an epic way. Doesn't she realize that's Angela's beat? She truly is the female Michael.
Then we see Dwight and Angela practically doing it in the wearhouse. (pause) Then we see Dwight and Angela practically doing it in the wearhouse. It is pretty amazing. And Dwight has the same beeper I bought from a drug dealer on the box ball court in 8th grade.
It's Pam's time to leave for the big city, and Michael BOLTS out of his office to catch her. He basically tumbles down 3 flights of stairs in order to utter his last word: Seagulls. And in other news, WHY IS MEREDITH SO BURNED?
Michael and Holly fake rap. Ed McMahon is proud.
The recap continues after the cut, including a video of the entire episode!
WEEK 3, July 14
Goodbye Pam, Hello Ronnie!
It's Pam's first day in class, and everything seems to be going swimmingly… only, she's in the wrong class. Let's face it — schedules are hard. But not as hard as Miracle Cleansing, the quick fix lemonade weight loss plan that Kelly Kapoor is sticking to to lose some quick poundage. I love Miracle Cleanse Kelly, and hope to see more (or less) of her in future episodes.
Jan is back, she's pregnant, and looks fantastic. No word on who the baby daddy is, but here's to hoping they write the birth into the storyline. Michael in the delivery room is what my people like to refer to as "Emmy Gold." Angela and Kevin get into a fight, and Holly learns the harsh truth: Kevin is not retarded. He's just fat and kind of slow. He's Kevin. In unrelated news, Phyllis has a charming new hairstyle and color. Pam and Jim have a Skype conversation on a thoughtfully placed Apple laptop, but is quickly intercepted by Michael Scott, who transports this digital floating Pam head over to her old desk to meet Ronnie. (Side note: Poor Ronnie.)
It's weigh in time! And despite everyone's best efforts, the group somehow gained 5 pounds. Who is the mole?
And then, Kelly Kapoor faints.
WEEK 4: July 21
Michael's goatee. No. Just — I can't.
Phyllis catches Angela and Dwight knocking clogs, and blackmails her way to head of the Party Planning Committee.
QUOTE BREAK: "I once went 28 years without having sex. And then again for 7 years" — Michael
Michael asks each employee to lose 5 pounds (and for Jim, 65.) Michael throws Jim some condoms for his Pam visit. And Andy keeps getting shut down by Angela, who is two-timing him basically in front of his face. Poor Andy. The Dunder party is a nightmare. It's all fruit and Dolly Parton and goatee. So the "cool kids" (everyone minus Michael, Holly, Dwight and Poor Ronnie) has a separate celebration in the warehouse with cake. Then Dwight kicks over their cake.
Once again, who is gaining weight?
WEEK 5, July 28
Ryan is back. Goooooooo-tee! And, in the sexiest secretary scene we've seen since Maggie Gyllenhaal saddled up, he's taking over for Pam as the new receptionist. And he's got a lot of making up today round the office. Then, Kelly swallowed a tapeworm. Sold to her by Creed. That wasn't a tapeworm.
Who THE HELL is gaining weight? Andy is not having it. Holly's date with Oscar's hot yoga teacher went well. Not seen? Michael Scott vomiting from sorrow. He calls Jim into the office and blames him for suggesting Michael be friends with Holly before lovers. Then Dwight selects three random names for liposuction: Stanley Phyllis Kevin. Later, in an effort to apologize, he offers to take Phyllis to a possible business deal where they will split the commission 60/40. She accepts, and I think, smiles her little Phyllis smile.
Ryan apologizes to Kelly for treating her badly. He blames 9/11 (don't we all?) and then suggests she pick him up at 8 for a drink. But she can't! Because she's in love with Darryl! His goatee has never looked weaker. Minutes later, Kelly and Darryl are making out on the reception couch.
Jim has been forced to lunch with Holly and Michael.
QUOTE BREAK: The Dreadmill!
Here's something exciting! Rich Sommer, who plays the bespeckled Harry Crane on Mad Men, makes an appearance as one of Pam's classmates in New York. Will he possibly lure little Pammy away from Jim? Probably not, but oh, the ~drama~. He will clearly make a move.
Dwight pushed Phyllis out of a car in a bad part of town, forcing her to walk 5 miles back to work. She calls David Wallace.
WEEK 6, August 4
No Weigh-In This Week.
Michael comes into the conference room in a fatsuit. Quite literally, it's a suit that is fat.
Meet Michael Clump, Michael's "fat man" persona based on Eddie Murphy's The Nutty Professor. Speaking of which, Dwight can do a KILLER Fat Albert impression! "I said I sit I sit I sit I sit on you." And can you really blame Mindy Kaling for not being able to keep a straight face during this scene? It's just too much. She's a beautiful Indian woman! Ryan thinks… she's perfect. And Creed chimes in that she's got a hell of an ass.
"This big fat pig is beautiful."
Ryan shaved his goatee. And Pam half-flirts with her new fake boyfriend in class.
QUOTE BREAK: "I hate that there's a worm inside of me."
WEEK 7, August 11
Let's just take a minute to savor Dwight's painted on goatee. Jim IM's Pam to come meet him for lunch halfway, at a truck stop where a soda exploded on him. Pam has also created an AMAZING ASCII Dwight, which you can print out here.
Michael asks Holly about her date. He hasn't called, which is inexcusable given she has Counting Crows tickets. The gang lost to Utica by 8 pounds, and Michael suggests everyone weighs in again at the end of the day. A few hours to lose a collective 8 pounds! That should be easy, especially once Andy cranks the heat up to 100 and dons a garbage bag dress.
Now, take a deep deep breath. Because it is at this moment in the show… that this happens:
JIM PROPOSES TO PAM. IN THE RAIN. AT A TRUCKSTOP. It's not a shmaltzy as one would have expected, but hey — IT HAPPENED. I'm greatful that they didn't super cheese it up. We have been through enough as a country with these two. It was short, it was sweet, and Jim was all smiles at the next weigh in.
Michael buys Holly's wasted Counting Crows tickets, and instead of then asking her to go with him, he tears them up. She doesn't get it. But seriously… WHO THE HELL WAS GAINING WEIGHT? It definitely wasn't Stanley! He lost 7 pounds! And he's gonna take 5 days off anyway. Now that's power.
WEEK 8, August 18
Toby hurt himself in a Costa Rican ziplining accident, and only has Entourage in Spanish to keep him company. Oh, if Michael could see him now.
VERDICT: In a word, satisfying. Hilarious. Exhilerating. It was a hell of a season premiere. Carell is still the star (and while I love Baldwin, I think Carell deserved the Best Actor in a Comedy Emmy moreso… he's never won one!), and the rest of the cast seems to have picked up from where they left off last season without little to no change. Dwight's a little more self-aware now, but thankfully, Creed is still a hobo.
- The Pam and Jim separation: How will this affect their relationship? And what's the deal with the new guy?
- Holly and Michael: Clearly, these two will eventually get together once Michael realizes she's his. Which will be a treat to behold.
- Kevin: Still kind of retarded.
- Angela and Dwight and Andy: I'm not looking forward to watching Andy's heartbreak. Unless he kicks around some more garbage cans. In which case: bring it.
- Kelly and Ryan: Obviously.
Here's the full episode if you missed it. And you can watch deleted scenes here. I await your comments.


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Rio All-Suite Hotel & Casino Las Vegas Debuts 380 Redesigned Samba Suites
New stylish and spacious suites on sale just in time for summer
Suggested Tweet: Take a look at the renovated @RioVegas Samba suites! Upgrade to the stylish 600 sq ft rooms: http://czr.bz/133via8
LAS VEGAS, May 7, 2013 /PRNewswire/ -- Las Vegas' Rio All-Suite Hotel & Casino announced today 380 redesigned Samba suites are now officially on sale. Located in the resort's notable Masquerade Tower, the fresh accommodations are available just in time for Vegas-goers to book their summer vacations.
(Photo: http://photos.prnewswire.com/prnh/20130507/LA09253)
The renovated designs, inspired by the lively, rhythmical Brazilian dance, will put guests in a festive mood. Energizing hues of teal and orange are incorporated throughout the spacious 600-square-foot suite with patterned carpets, dark wood furnishings, brushed chrome fixtures, a 32-inch flat screen television and upgraded bathrooms featuring granite countertops, tile flooring and a walk-in shower. Samba suites http://czr.bz/133via8 at Rio Las Vegas start at $59 per night.
"The all-new Samba suites are an incredible value," said Director of Operations Kevin Donnelly. "Guests will enjoy a spacious suite in an exciting new design within footsteps of great restaurants and entertainment for a true Vegas experience."
Rio Las Vegas is the perfect Las Vegas resort to soak in the sun this summer. VooDoo Beach Pool features real sand beaches, cascading waterfalls, four swimming pools and five whirlpool spas. Two outdoor bars offer a selection of specialty cocktails made by some of the city's top flair bartenders. For an adult experience, The Voo offers guests 21 and older a lively pool party experience with a live DJ and high-energy go-go dancers.
Rio All-Suite Hotel & Casino
Rio All-Suite Hotel & Casino, home of the World Series of Poker, offers guests a unique all-suite hotel experience. Complete with 2,522 all-suite hotel rooms, the property overlooks the famous Las Vegas Strip and sits one block west of the famed boulevard. The resort features a variety of entertainment options including headliners Penn & Teller, the world-famous Chippendales and Crown Theater. Rio is home to a diverse array of dining and nightlife experiences including, the famous Martorano's, Voodoo Steak, KJ Dim Sum & Seafood, iBar and VooDoo Beach. Rio also offers the Rio Secco Golf Club. Recognized by USA Today as one of the "Top 10 Golf Destinations in the World," Rio Secco Golf Club is an 18-hole championship course designed by famed architect Rees Jones and home to the Butch Harmon School of Golf. For more information, please visit www.riolasvegas.com or caesars.thedigitalcenter.com to access media materials and request high-resolution images. Find Rio on Facebook and follow on Twitter.
SOURCE Rio All-Suite Hotel & CasinoBack to top


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June 1, 2004
HOT SPRINGS, Va. - The University of New Mexico men's golf team is currently in 17th placer after the first round of the NCAA Championships. The Lobos shot an opening round 11-over par 291 on the par-70, 6,679 yard, The Cascades Course at The Homestead Resort in Hot Springs, Va. New Mexico trails the opening round leader California-Berkley by 12 strokes as the Bears shot a 1-under par 279 and lead BYU by one stroke.
Individually the Lobos were led by junior Madalitso Muthiya with an even par round of 71 to end the opening round tied for 20th. Sophomore Spencer Levin was next for UNM with a 2-over par 73 and is tied for 52nd. Other individual New Mexico results are junior Jay Reynolds is 3-over par (73), tied for 65th, freshman Charlie Beljan is 6-over par (76), tied for 121st and sophomore Jay Choi is 7-over par (77), tied for 132nd.
The overall individual lead belongs to Jeff Hood of California-Berkley with a 5-under par 65 and leads Kevin Kisner of BYU and Adam Meyer of TCU by one stroke.
The NCAA Championships continue tomorrow with the second of four rounds at The Cascades Coures at The Homestead Resort in Hot Springs, Va. with tee times beginning at 7:00 AM (EST). New Mexico is scheduled to tee off at 7:18 AM (EST) with updated statistics at www.golfstat.com


text: NFL Week 14 Recap- Adam Pacman Jones Makes News On and Off the Field NFL Week 14 Recap- Adam Pacman Jones Makes News On and Off the Field Featured SHARE Caleb Wygal , December 13, 2011 / 285 1 During Week 14 of NFL play, four teams locked up Playoff berths. Conversely, on Monday, the Dolphins and Chiefs fired their head coaches following losses. Both of those teams have former Mountaineers on their rosters. On the field, from a Mountaineer perspective, Adam Jones was flagged for a costly pass interference penalty, and after the game, it came out that Jones had spit in the face of a Texans wide receiver. I'll tell you his response to both events below. Mortty Ivy had a career first for the Steelers, while Ryan Mundy had a career second nullified. I'll explain. Ellis Lankster was inactive for the Jets for the third straight week. He missed practice last week with lower back problems. I'll explain why the Jets need Lankster back soon. Houston 20- Cincinnati 19 Adam Jones had a pass interference penalty called on him with 12 seconds left in the game as the T.J. Yates and the Texans drove the field for what was the game-winning touchdown. The call put the ball on the Bengals' 6 yard-line after Jones' grab of Texans' wide receiver Jacoby Jones. The Texans scored the game-winning touchdown two plays later. After the game, Jones took responsibility for the call. "It was a touchy call. It wasn't a hold," Jones said. "It's nobody else's fault but my fault. There is no excuse for me to make that play. I don't think the ball was catchable, but that's my own opinion. I'm just hot that we lost. I can't believe that." On Monday, a story came out that Jones had spit in the face of Texans' FB Lawrence Vickers. Vickers said he shoved Jones as he grabbed the legs of Texans' RB Ben Tate during a pile-up. That's when Vickers said Jones let the loogie fly. "I prayed for that man,"Vickers told the Houston Chronicle. "I had to let the Lord handle him. The Lord don't put bad things on people, but I left it up to Him. I prayed real hard — I almost lost myself out there." The two teams played in front of 41,202 fans – the second smallest crowd to ever see the Bengals play at Paul Brown Stadium. On Nov. 12, the Mountaineers played the Bearcats in the same stadium. That game drew an attendance of 48,152. Adam Jones ended the game with 4 tackles and a pass breakup. Robert Sands was inactive. Cleveland 3- Pittsburgh 14 Mortty Ivy was active for this game and played on the Steelers' special teams units. He recorded his 1st career tackle during regular season play. Ryan Mundy would have had his 2nd career interception, but it was called back due to a penalty. Kansas City 10- N.Y. Jets 37 After getting thrashed by the Jets, Chiefs head coach Todd Haley was let go. For the Jets, Ellis Lankster sat out with the lower back injury, but the Jets need the former Mountaineer back soon. Starting safety Jim Leonhard tore the patellar tendon in his right knee and is out for the rest of the season. Philadelphia 26- Miami 10 The Miami loss to Philadelphia dropped the team to 4-9 on the season. On Monday, the Dolphins dropped head coach Tony Sparano. Steve Slaton was inactive for the Dolphins. Owen Schmitt did not show up on the stat sheet or in the game notes. New England 34- Washington 27 Chris Neild did not record any stats. Indianapolis 10- Baltimore 24 Pat McAfee recorded another special team tackle to add to his league lead of tackles among kickers. He has the best hangtime in the League among punters and is in the Top-10 in punts going out-of-bounds inside the 20-yard-line. Buffalo 10- San Diego 37 Corey McIntyre and the Bills traveled out west and lost their 6th game in a row. Bookmark on Delicious Digg this post Recommend on Facebook Share on Posterous share via Reddit Share with Stumblers Tumblr it Tweet about it Buzz it up Subscribe to the comments on this post Print for later Tell a friend


text:
Comment Re:Gun nuts (Score 4, Informative) 1374
Comment Google being sued over use in schools (Score 1) 409
Comment Re:Slashdot misunderstands value of patents (Score 4, Informative) 84
Comment Slashdot misunderstands value of patents (Score 4, Informative) 84
1 - Apple gets patent
2 - Apple sells patent to Irish subsidiary for small amount of money
3 - Apple comes out with iPhone that incorporates patented technology.
4 - Apple pays subsidiary royalty on patent for each iPhone sold
In this way, Apple moves profit on iPhone sales from Apple itself to the subsidiary. The subsidiary is incorporated in Ireland, so it is not taxable in the US. The subsidiary's major operations are in the US, so it is not taxable in Ireland.
Profit!! Tax-free!!
Patents are no longer an IP strategy. They're a tax avoidance strategy.
Comment Re:Problem with egos really (Score 1) 525
To be fair, the "NYT" didn't lie - Broder did. The NYT backed up one of their journalists. Which they should!
WRONG. The editor should have read the article, said "You're full of shit" and rejected it.
You don't throw your soldiers out into the enemies tender mercies, just 'cause.
No, the NY TImes did not blindly defend Broder. The NY Times has a "Public Editor" - an independent source who investigates and publicly discusses whether the Times did the right thing on controversial stories. She's been looking into this controversy pretty closely - see her blog. She hasn't finished her investigation, but she does say "I reject Mr. Musk's central contention that Mr. Broder's Sunday piece was faked in order to sabotage the Model S or the electric-car industry."
Like any organization, the NY Times makes mistakes. But they have enough integrity to own up to it when they do.
Comment Re:At last an offer. (Score 1) 582
And Apple is free not to license those patents and come up with a new and unique way of doing it.
No. That's the whole point of a FRAND patent. Apple is not free to do it some other way. Apple needs to follow the standard. The deal is that Moto's tech gets to be in the standard because they agree to license it freely and relatively cheaply.
Comment Re:Ironic (Score 1) 606
I'm not sure what you think inflation means, but it has nothing to do with whatever it is you think you're calculating. CPI blahblahblah...
Inflation can be measured both in terms of dollars in existence (which he is measuring) and in terms of prices, which the CPI purports to measure.
No. Inflation can only be measured in terms of prices. Tripling the money supply does not triple prices (at least not always). If you haven't learned that from the non-reaction of inflation to QE, then you must believe your "theory" trumps all evidence.
As far as the CPI all being a government conspiracy of some kind, if you don't believe it, just use the BPI. Still no price rise in reaction to expansion of the money supply. But maybe MIT is in on the conspiracy...
Comment Re:Ironic (Score 1) 606
I guess your model is that price changes count when you say they do (VW bugs) but can be dismissed when you think they're not reflective of the "real" price (electronics and jeans).
I agree that wages for many have not kept up with inflation, but I have no idea what that has to do with the level of inflation itself.
Measuring prices for the CPI is hard and there are tons of papers arguing various aspects of the methodology but there's no reason to believe there's some kind of conspiracy to hide inflation. The BPI, which is privately produced and uses a completely different method of measuring prices, basically matches the CPI.
Comment Re:Ironic (Score 4, Informative) 606
Comment Re:I've got a solution.... (Score 1) 83
Sorry, yes it does. Not because of the impact on discrimination, but because the companies now have the added cost of documenting that they do not discriminate. This is one more cost that makes it more difficult for a smaller company to survive in the market.
No. This does impose a cost, but the cost is the same for all companies in the market, so it doesn't disadvantage the small company (well, possibly there are economies of scale in favor of the larger company but that's not necessarily true and, in any case, those economies of scale apply to lots of things that have nothing to do with regulation). In any case, the cost is really small. Documenting non-discrimination is basically documenting how the company came up with the rate. If they don't already document that, then they aren't going to survive long.
I happen to think that it is not the government's business to enforce anti-discrimination practices on private companies. What people seem to forget is that the segregationist policies that lead to the Civil Rights marches were not a result of lack of government regulation, they were a result of government regulation.
I think people seem to forget that because it isn't true. In what way was Woolworth's refusal to serve blacks at their lunch counter a result of government regulation? American General Life charged black customers more for insurance than white. In what way was this a result of regulation?
Comment Re:I've got a solution.... (Score 1) 83
How about anti-trust laws? They require a whole bunch of regulations for corporate reporting approval of mergers, etc. The whole purpose of these regulations is to increase competition. You might try to argue that you have some brilliant new set of anti-trust laws that would do a better job (and maybe you do, though I doubt it), but you're insane if you think that fewer anti-trust regulations will, necessarily, lead to more competition. We know what happened before anti-trust.
So look at anti-discrimination regulations. Insurance companies, for example, are not allowed to price based on race, even if their research shows that race is a predictor of life expectancy. Does this reduce competition among insurance companies? No - the companies just adjust their tables to price for the average across races. There's an even playing field for the companies, so the industry is every bit as competitive as it would be without these laws. In fact, this is a case where regulation is essential (unless you think that discrimination by race would be OK). If you left this to the unregulated free market, then any insurance company that advertised that it didn't use race in rating policies would rapidly go out of business, as it would attract mostly high-risk customers but would need to price to the average. Government regulations help keep the playing field even.
Comment Re:Oh look... (Score 0) 170
Don't get me wrong - I like Cook, and I think he's smart and a really hard worker. But, honestly, do you really think that someone with hundreds of millions of dollars really finds the prospect of getting N hundred million more all that motivating?
Guys like Jobs and Cook work hard because that's what they want to do with their lives. The money gives them bragging rights over other CEOs but, really, I don't think Cook's going to do the job any differently, just because he has the prospect of an enormous payoff down the road.
Comment Re:Oh look... (Score 2) 170
Comment Apple Data Detectors (Score 4, Informative) 230
This article describes ADD, including what its developers considered to be unique and different from other approaches.
My take on this is that ADD did come up with some clever ideas in implementation that solved the particular problems they were addressing (focusing on simple problems and fast detection). It's clear that what's unique is the particular implementation, not the idea of detecting phone numbers and such. They cite lots of other examples of the idea.
So, there are two possibilities. Either the patent covers the idea (and thus is inappropriately broad and will be ruled invalid) or the patent is about the particular implementation, in which case it should be simple to implement in a way that avoids violation. In either case, HTC and Android will be fine.


text: Telecoms Latest in Telecoms To receive latest news & articles, sign up for our email newsletter! Subscribe Today! Latest Download! Mass Notification and Emergency Communication Installation Guidelines for SpectrAlert Advance This FREE downloadable paper aims to show proper installation of Outdoor… Security Systems Technician SECURITY ALARM SERVICE TECHNICIAN Security Technician Fire Alarm Technician Electronics Security Salesperson Find or Post Jobs Post your resume today! Trending 8 Hilarious Security Signs 10 Amusing Security Memes Industry Mourns Loss of Long-Time CCTV Exec Frank DeFina Lawsuit Against TycoIS Over Eli Lilly Warehouse Heist Moves Forward How Diebold Won SSI's Installer of the Year Award


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This story has been reproduced from today's media. It does not necessarily represent the position of Liverpool Football Club.
Liverpool FC have increased their offer for Adam Lallana to £25million as his Southampton clubmate Rickie Lambert prepares to complete his £4million move to Anfield.
The Reds' initial bid of £20million for Lallana was rejected by Saints earlier this month and further talks failed to reach a suitable compromise.
Anfield officials have now launched another attempt to secure the England midfielder's services and are awaiting a response from the South Coast outfit, who have been demanding £30million.
The situation is complicated by the fact that Southampton will have to pass on a significant chunk of the fee to Bournemouth, who boast a 25% sell-on clause.
Boss Brendan Rodgers had hoped to get a deal for Saints skipper Lallana completed prior to the World Cup finals but Liverpool are running out of time to make that happen.
The ECHO understands the increased bid of £25million is a 'take it or leave it' offer with the Reds having no intention of going higher than that figure.
If that final offer doesn't trigger a breakthrough in negotiations then Liverpool will walk away and turn their attentions to other targets such as Bayern Munich's Xherdan Shaqiri.
Lallana has attracted interest from a number of clubs but he has his heart set on playing Champions League football at Anfield next season.
His Southampton clubmate Lambert will secure his dream switch to Liverpool over the next 48 hours.
The Kirkby-born 32-year-old will undergo a medical on Merseyside on Saturday after the Reds agreed a fee of £4million plus add-ons for the England international.
Lambert, who scored 117 goals in 235 games for Saints, has already agreed personal terms and will pen a two-year contract.
He left the England camp following Friday night's 3-0 win over Peru at Wembley to complete the formalities prior to flying off to Miami with Roy Hodgson's men on Sunday.
The paperwork will be completed over the weekend and an official announcement will follow from the club on either Sunday or Monday.
Liverpool are also working on completing a deal for highly-rated Sevilla left-back Alberto Moreno.
The Reds have been encouraged by the response from the La Liga outfit to their opening offer of £16million this week and are increasingly confident they will land the Spain international.
Source: Liverpool Echo
This story has been reproduced from today's media. It does not necessarily represent the position of Liverpool Football Club.
Tagged: Adam Lallana , Rickie Lambert
Submit your views in the box below. Alternatively, you can debate these issues with fellow fans on our Message Boards or blog about them on The Kop
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Mariah Carey
Mariah Carey Stumbles Again in Live Performance of 'Fantasy'
The troubles of the Christmas Tree Lighting performance are still here.
Mariah Carey Announces Las Vegas Residency
Mariah Carey will be taking on Las Vegas. The singer has just announced her first Las Vegas residency at Caesars Palace.
10 Crazy Facts You Didn't Know About 2014's Biggest Hits
Who was considering recording "All About That Bass" and how did producers stop "Shake It Off" from leaking before the release date will BLOW YOUR MIND!
Mariah Carey's 'All I Want for Christmas is You' Performance Didn't Go So Well Last Night
Hey, at least it wasn't as bad as 'Glitter.'
Fifth Harmony are Merry in 'All I Want for Christmas Is You' Video: Watch
Listen to the ladies take on the Mariah Carey holiday classic.
Mariah Carey Announces New York City Christmas Concerts
All Mariah Carey wants for Christmas is you — to attend her Christmas concerts in New York City.
The Real Reason Mariah Carey And Nick Cannon Are Separated
Could this picture of AMP Radio's own James Steele be the reason that Mariah Carey and Nick Cannon are separated?
Mariah Carey Parts Ways with Manager Jermaine Dupri
Mariah Carey has parted ways with her longtime manager and musical collaborator Jermaine Dupri, Billboard reports.
Stream Mariah Carey's 14th Album, 'Me. I Am Mariah… The Elusive Chanteuse'
Mariah Carey may not have pulled a Beyoncé with her new album, opting to toss a collection of new songs onto the Internet at not even a moment's notice. That doesn't, however, mean the record didn't sneak up on gracious listeners.
Radio Feedback: Mariah Carey Popularizes Melisma with Debut Single
It was a New York moment for Mariah Carey, the first time she heard herself on the radio. The Long Island native told Radio.com about the first time she heard her breakthrough single "Vision of Love" on the radio, but more importantly, she remembers it being a revolutionary moment.


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From per adult/week
Our Resort welcomes children of all ages with supervision, for each age group
From 4 to 10 years, children have a thirst for everything, Mini Club Med has planned everything in order to meet these needs.
Juniors' Club Med brings together young people aged between 11 and 17 years, and provides them a place to discover creative, sports, artistic activities, or simply just hang out together... Along our trusted G.O.s ®, they are free to pursue their passions! Open 7 days a week
At this age children are no longer babies, but they still need close supervision.
This is the time for new discoveries: stimulating fun, walks and outside play, full balanced lunch (specially formulated for the needs of young children), nap or quiet time, creative activities and, of course, the afternoon snack, a real feast for hungry kids! The activities follow the children's progress, and vary according to the age range. From 7.30 p.m., after dinner with the parents, it's back to the Petit Club Med®. While the parents eat in peace, the children finish the day with a quiet evening get-together.
For your information: diapers and baby milk are not provided at the Petit Club Med®.
Access conditions :
Schedule : 9 a.m. to 5.30 p.m. and 7.30 to 9 p.m.
Duration : From 8.30 am to 5 pm and from 6.45 pm to 8.30 pm, every day
Minimum age : 2 year(s)
Maximum age : 3 year(s)
Children must be up to date with their diphtheria, tetanus and polio jabs. On your arrival at the Resort, you'll be required to present a document showing the child's health record.
Diapers and formula are not provided by Baby Club Med®.
Create and let off steam. At these ages, children are hungry for everything... The Mini Club Med® has thought of everything to fulfil this constant need for new experiences. Sports, fun and creative activities.
Children are divided into subgroups by age.
Access conditions :
Duration : From 8.30 am to 5 pm and from 6.45 pm to 8.30 pm, every day
Minimum age : 4 year(s)
Maximum age : 10 year(s)
It is a great classic of the Club Med for teenagers, in which they are split into 2 age groups.
Teenagers, independence and parties. Club Med offers everything but imposes nothing. A true state of mind, both free and exclusive, which thrills the young. The Juniors' Club Med® enables teenagers to meet among themselves and participate in activities of their choice while taking part in the life of the Resort.For your information: Available all year round.
For your information
Available all year round.
Access conditions :
Duration : From 9.30 am to 7 pm and from 7 pm to 8.30 pm, every day
Minimum age : 11 year(s)
Maximum age : 17 year(s)
From 11 to under 18 years old.
Teen agers are under the responsability of the GOs only during the organized activities.
Available only during the school vacations
This Baby corner, located in the main restaurant, has savoury and sweet baby foods and all the equipment necessary for preparing babies' meals.
To enjoy a moment of total freedom, take advantage of the baby-sitting service. For information: we provide a list of baby-sitting services on request. These outside service providers bear the entire responsibility for the services they provide; the Club Med provides the contact but has no responsibility for the service.
The little darlings feel right at home thanks to this service, included in your Package. Everything has been thought of as concerns the babies' comfort and the parents' well-being.
Clean Art Planet drives the childrens attention towards the environment. This original activity gives another meaning to all objects that the men threw in the ocean and the ocean threw back: plastic, bottles, caps, flip flops... then with various artistic workshops they are turned into amazing colorful objects.
Once the objects are collected by the adults, the kids transform them in to amazing objects, create stories around them and even pictures.A nice way to learn on how to protect our planet.
Access conditions :
Minimum age : 4 year(s)
Maximum age : 10 year(s)
Culinary activity offered within the Mini Club Med activities to learn all about the local cuisine. The parents can then taste their childrens treats.
Access conditions :
Minimum age : 4 year(s)
Maximum age : 10 year(s)
Circus workshops for children from 4 to 6 years old at Mini Club Med®, to discover the joys of the circus in small groups, with G.O®s trained in their discipline. The children take part in a show, where they can demonstrate what they have learnt
Access conditions :
Minimum age : 4 year(s)
Maximum age : 5 year(s)
Club Med Spa now proposes specific beauty treatments for teenagers(excluding massage**), at set times in the day, to introduce them to the World of Wellness. An experience to try on your own, with Mum or with your friends.
Reservations on site only.
** For information:
The term "massage" implies a superficial manipulation of the face or body, solely for aesthetic purposes, sometimes to ensure good penetration of a cosmetic product, or for comfort. The massage referred to is an external massage of the skin, with no medical or therapeutic aim. It may be done manually or with mechanical aids, exclusively by qualified, trained professionals.
Access conditions :
Minimum age : 11 year(s)
Maximum age : 17 year(s)
Price is per adult, based on double occupancy (room category based on availability).
Membership fees of $60/adult are not included in the price calendar.
Prices and availability updated 12 hours ago
Please login to your personal account to continue. If you are not registered yet, create your account below. Visit www.clubmed.us and click on the My Club Med menu if you would like to sign up for your own account.
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Saffron Walden woman fined for crashing car into neighbour's house whilst drunk
Posted: May 14, 2014|
A Saffron Walden woman who crashed a Land Rover into the side of a neighbour's house while over the limit has been fined £100 and banned from driving for a year.
Gemma Louise Gadsby, 28, of Loompits Way, Saffron Walden, pleaded guilty to driving while over the drink drive limit when she crashed the car causing "extreme damage" to the neighbour's house on April 27.
Gadsby was ordered to pay £85 costs and £20 victim surcharge for the incident, but no compensation was ordered for the damage.
At Chelmsford Magistrates Court, Gadsby also pleaded quilty to driving without a licence and insurance and failing to stop after the accident - but received no penalty for those offences.
Emma Howson, prosecuting, told the court: "At 6.55am Brian Page woke at his home in Loompits Way and heard a loud bang.
"He looked out of the window and saw a female walking away from the parking area the side of his house.
"Five minutes later he looked out again and saw the female again walking away from the parking area.
"At 8am he went downstairs and noticed extreme damage to the wall inside the property by the parking bays.
"He noticed the downstairs toilet had a cracked sink and damage to the door frame and damage to the skirting board, plaster and paintwork.
"He went outside and saw a Land Rover Discovery parked about a metre from the wall.
"There was damage to the front bumper, the headlights smashed and cracks to the front windscreen.
"It was established the vehicle was from a neighbouring property.
"Police spoke to the defendant who said the car was used by her partner who wasn't at the address and she didn't have the keys.
"After further enquiries she was arrested and said that after the accident she had gone home and had two mugs of wine.
"Breath tested, she had a reading of 56 microgrammes.
Louise Maples, mitigating, said Gadsby got into the car, turned on the ignition and it was in first gear and "shot into the wall."
It happened after she had got up and found her boyfriend wasn't at home.


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We made a volcano... but, why did we do a simple volcano? It's easy, well... volcanos are not a simple thing, I mean, they are not just a rupture in the surface which allows hot lava and volcanic ashes.
Generally, they're formed at the boundaries of the tecntonic plates, inside has open fires where the lava rises from the magma chamber, a reservoir where lava accumulates.
So, what we did for our science fair was a little volcano which would represent a real volcano eruption so people could understand better the process it requires.
Step 1: Volcanoes!
A volcano is an opening, or rupture, in a planet's surface which allows hot, molten rock, ash, and gases to escape from below the surface. Volcanic activity involving the extrusion of rock tends to form mountains or features like mountains over a period of time.
Volcanoes are generally found where tectonic plates are diverging. Volcanoes can also form where there is stretching and thinning of the Earth's crust.
Step 2: How volcanoes work?
A volcanic event occurs when there is a sudden or continuing release of energy caused by near-surface or surface magma movement. The energy can be in the form of earthquakes, gas-emission at the surface, release of heat, which is geothermal activity, explosive release of gases (including steam with the interaction of magma and surface of ground water), and the non-explosive extrusion or intrusion of magma.
An event could be non-destructive without release of solids or magmatic liquid, or if there is anything to destroy, could be destructive with voluminous lava flows or explosive activity. Destruction usually refers to the works of mankind (buildings, roads, agricultural land, etc.).


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Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
1. A composition comprising:
a bioerodable material comprising a first component and a second component;
a bioerodable carrier dispersed throughout one of the first component or the second component, the bioerodable carrier comprising a microfiber having a length of 0.5 μm to 500 μm; and
a treatment agent disposed within the bioerodable carrier.
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This is a continuation-in-part of application Ser. No. 11/361,920, filed Feb. 23, 2006, which is a continuation-in-part of application Ser. No. 11/110,223, filed Apr. 19, 2005, now pending.
Post-myocardial infarction treatments and compositions.
Ischemic heart disease typically results from an imbalance between the myocardial blood flow and the metabolic demand of the myocardium. Progressive atherosclerosis with increasing occlusion of coronary arteries leads to a reduction in coronary blood flow. "Atherosclerosis" is a type of arteriosclerosis in which cells including smooth muscle cells and macrophages, fatty substances, cholesterol, cellular waste product, calcium and fibrin build up in the inner lining of a body vessel. "Arteriosclerosis" refers to the thickening and hardening of arteries. Blood flow can be further decreased by additional events such as changes in circulation that lead to hypoperfusion, vasospasm or thrombosis.
Myocardial infarction (MI) is one form of heart disease that often results from the sudden lack of supply of oxygen and other nutrients. The lack of blood supply is a result of a closure of the coronary artery (or any other artery feeding the heart) which nourishes a particular part of the heart muscle. The cause of this event is generally attributed to arteriosclerosis in coronary vessels.
Formerly, it was believed that an MI was caused from a slow progression of closure from, for example, 95% then to 100%. However, an MI can also be a result of minor blockages where, for example, there is a rupture of the cholesterol plaque resulting in blood clotting within the artery. Thus, the flow of blood is blocked and downstream cellular damage occurs. This damage can cause irregular rhythms that can be fatal, even though the remaining muscle is strong enough to pump a sufficient amount of blood. As a result of this insult to the heart tissue, scar tissue tends to naturally form.
Various procedures, including mechanical and therapeutic agent application procedures, are known for reopening blocked arties. An example of a mechanical procedure includes balloon angioplasty with stenting, while an example of a therapeutic agent application includes the administration of a thrombolytic agent, such as urokinase. Such procedures do not, however, treat actual tissue damage to the heart. Other systemic drugs, such as ACE-inhibitors and Beta-blockers, may be effective in reducing cardiac load post-MI, although a significant portion of the population that experiences a major MI ultimately develop heart failure.
An important component in the progression to heart failure is remodeling of the heart due to mismatched mechanical forces between the infracted region and the healthy tissue resulting in uneven stress and strain distribution in the left ventricle. Once an MI occurs, remodeling of the heart begins. The principle components of the remodeling event include myocyte death, edema and inflammation, followed by fibroblast infiltration and collagen deposition, and finally scar formation. The principle component of the scar is collagen. Since mature myocytes of an adult are not regenerated, the infarct region experiences significant thinning. Myocyte loss is the major etiologic factor of wall thinning and chamber dilation that may ultimately lead to progression of cardiac myopathy. In other areas, remote regions experience hypertrophy (thickening) resulting in an overall enlargement of the left ventricle. This is the end result of the remodeling cascade. These changes in the heart result in changes in the patient's lifestyle and their ability to walk and to exercise. These changes also correlate with physiological changes that result in increase in blood pressure and worsening systolic and diastolic performance.
Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier may be loaded with a treatment agent. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in one component of a two-component matrix for simultaneous delivery to a post-myocardial infarction treatment area.
Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
Treatment Agents
Treatment agents to treat post-myocardial infarction treatment areas may include: (i) agents that promote angiogenesis (angiogenesis promoting factors); (ii) agents that promote cell survival (cell survival promoting factors); and (iii) agents that recruit endogenous progenitor and/or stem cells (endogenous recruiting factors). Various forms of treatment agents are intended to include, but are not intended to be limited to, drugs, biologically active agents, chemically active agents, therapeutic agents, and the like, and pharmaceutical compositions thereof, which can be used in the delivery of a treatment agent to a treatment site as described herein.
"Angiogenesis" is the promotion or causation of the formation of new blood vessels. After an MI, the infarct tissue as well as the border zone and the remote zone around the infarct tissue begin to remodel. Scar tissue forms in the infarct region as the granulation is replaced with collagen. Stress from blood pressure cause the scar to thin out and stretch. The perfusion in this region is typically 10% of the healthy zone, decreasing the number of active capillaries. Increasing the number of capillaries may lead to an increase in compliance of the ventricle due to filling up with blood. Other benefits of increasing blood flow to the infarcted region include providing a route for circulating stem cells to seed and proliferate in the infarct region. Angiogenesis may also lead to increased oxygenation for the surviving cellular islets within the infarct region, or to prime the infarct region for subsequent cell transplantation for myocardial regeneration. In the border zone, surviving cells would also benefit from an increase in blood supply through an angiogenesis process. In the remote zone, where cardiac cells tend to hypertrophy and become surrounded with some interstitial fibrosis, the ability of cells to receive oxygen and therefore function to full capacity are also compromised; thus, angiogenesis would be beneficial in these regions as well.
In some embodiments, angiogenesis promoting factors include, but are not intended to be limited to, growth factors such as isoforms of vasoendothelial growth factor (VEGF), fibroblast growth factor (FGF, e.g. beta-FGF), Del 1, hypoxia inducing factor (HIF 1-alpha), monocyte chemoattractant protein (MCP-1), nicotine, platelet derived growth factor (PDGF), insulin-like growth factor 1 (IGF-1), transforming growth factor (TGF alpha), hepatocyte growth factor (HGF), estrogens, follistatin, proliferin, prostaglandin E1 and E2, tumor necrosis factor (TNF-alpha), interleukin 8 (I1-8), hematopoietic growth factors, erythropoietin, granulocyte-colony stimulating factors (G-CSF) and platelet-derived endothelial growth factor (PD-ECGF). In some embodiments, angiogenesis promoting factors include, but are not intended to be limited to, peptides, such as PR39, PR11 and angiogenin, small molecules, such as PHD inhibitors, or other agents, such as eNOS enhancers.
Endogenous cardiomyocyte (myocytes) apoptosis is the major etiological factor of wall thinning and chamber dilation and may ultimately lead to progression of cardiac myopathy. After an infarction, mature myocytes of an adult are not regenerated which can lead to significant thinning in the infarct region. Thus, factors which promote cell survival applied to the infarct region are believed to be beneficial. In some embodiments, cell survival promoting factors include, but are not intended to be limited to, growth factors such as insulin-like growth factor (IGF-1) and human growth factor (HGF), which are known to mediate cell growth, differentiation and survival of a variety of cell types. In addition, small molecules such as, for example, HMG-CoA reductase inhibitors (statins) and capsase inhibitors can also promote cell survival and inhibit apoptosis.
To assist in the generation of new cells at the infarct region, autologous or allogeneic stem cells may be delivered to a patient. "Autologous" means the donor and recipient of the stem cells are the same. "Allogeneic" means the donor and recipient of the stem cells are different. Cell survival promoting factors can also be used to increase the survivability of autologous and allogeneic implanted stem cells at the infarct region.
Cardiac progenitor cells are highly specialized stem cells which have shown the ability to differentiate into certain types of fully mature cardiac tissue. Examples of cardiac progenitor cells include, but are not limited to, c-Kit(+), Sca-1(+) and Isl-1(+). Thus, factors which recruit endogenous factors when applied to the infarct region are believed to be beneficial. In some embodiments, an endogenous recruiting factor can include, for example, HGF. HGF has been shown to control cell motility and promote cell migration. If applied post-infarction, HGF can assist in mobilizing and recruiting resident cardiac progenitor cells to the infarct region. In some embodiments, an endogenous recruiting factor can include, but is not intended to be limited to, stromal cell-derived factor 1 (SDF-1). SDF-1 is the ligand for the CXCR4 receptor, which is a surface receptor on circulating endothelial progenitor cells. Thus, when applied in or around the infarct region, SDF-1 may facilitate the homing of circulating endothelial progenitor cells to induce neovascularization.
It is contemplated that any of the above-described treatment agents can be used singularly or in combination thereof. In addition, other treatment agents, including but not limited to, anti-inflamrnatory, anti-platelet, anti-coagulant, anti-fibrin, anti-thrombotic, anti-mitotic, anti-biotic, anti-allergic, anti-oxidant, anti-proliferative, or anti-migratory agents, may be optionally used singularly or in combination thereof.
Sustained-Release Carriers
Bioerodable carriers (hereinafter interchangeably referred to as sustained-release carriers) infused with (or without) a treatment agent can be used for the sustained or controlled release of treatment agent for maximum benefit to the infarct region. It is believed that a large percentage of treatment agent delivered directly to the infarct region, or even diffused within a gel-like matrix, will be substantially washed away by the body's natural mechanisms, thus lessening the benefit of the treatment agent that may otherwise be obtained. Thus, sustained-release carriers infused with treatment agent that release the treatment agent over an extended time period can be beneficial by increasing the amount of time in which the infarct region is exposed to the treatment agent. Sustained-release carriers include, but are not limited to, (i) microparticles or nanoparticles (hereinafter interchangeably referred to as microparticles), (ii) microfibers or nanofibers (hereinafter interchangeably referred to as microfibers) and (iii) liposomes and polymerosomes.
In addition, in some embodiments, a bioerodable carrier may be infused with (or without) a treatment agent and delivered to a treatment site to act as a "docking site" for endogenous myocardial stem cells and encourage their differentiation into cardiomyocytes.
In some embodiments, the sustained-release carrier is a microparticle. Various methods can be employed to formulate and infuse or load the microparticles with treatment agent. In some embodiments, the microparticles are prepared by a water/oil/water (W/O/W) double emulsion method. In the WI phase, an aqueous phase containing treatment agent, is dispersed into the oil phase consisting of polymer dissolved in organic solvent (e.g., dichloromethane) using a high-speed homogenizer. Examples of sustained-release polymers include, but are not limited to, poly(D,L-lactide-co-glycolide) (PLGA), poly(D,L-lactide) (PLA) or PLA-PEEP co-polymers, poly-ester-amide co-polymers (PEA) and polyphophazines. The primary water-in-oil (W/O) emulsion is then dispersed to an aqueous solution containing a polymeric surfactant, e.g., poly(vinyl alcohol) (PVA), and further homogenized to produce a W/O/W emulsion. After stirring for several hours, the microparticles are collected by filtration.
In some embodiments, the sustained-release carrier is a microfiber or nanofiber. For example, the treatment agent (or no treatment agent) infused microfiber can be formulated by electrospinning. "Electrospinning" is a process by which microfibers are formed by using an electric field to draw a polymer solution from the tip of a capillary to a collector. A voltage is applied to the polymer solution which causes a stream of solution to be drawn toward a grounded collector. Electrospinning generates a web of fibers which can be subsequently processed into smaller lengths.
Examples of sustained-release polymers which can be used in electrospinning include, but are not limited to, PLGA, PLA or PLA-PEEP co-polymers, PEA, polyphosphazines and collagen. In one method, the treatment agent is mixed with a bioerodable polymer solution, a solvent and a surfactant. Examples of surfactants can include, but are not limited to, anionic or cationic surfactants. Useful anionic surfactants include, but are not intended to be limited to, bis(2-ethylhexyl) sodium sulfosuccinate (AOT), bis (2-ethylhexyl) phosphate (NaDEHP), tauroglycocholate, and sodium lauryl sulfate. A useful cationic surfactant is tetradecyltrimethyl-ammonium bromide (TTAB). An example of a solvent includes, but is not limited to, hexafluoro isopropanol. The treatment agent-infused polymer solution is then subjected to electrospinning. As the solvent evaporates during electrospinning, the treatment agent incorporates and distributes within the polymer by non-covalent interactions. The resultant microfibers which can be from about 0.5 μm to about 3 μm in diameter form a web which may then be processed into smaller lengths of about 0.5 μm to about 500 μm. Based on the treatment agent, in some applications, microfibers may be a preferred sustained-release carrier due to the non-aqueous process by which they are formed. In some applications, microspheres may be preferable when the treatment agent is hydrophilic. In some applications, a microfiber is a preferred sustained-release carrier due to its release pharmacokinetic profile when compared to the release pharmacokinetic profile of a microsphere. In some cases, microspheres as well as microfibers can be used as a carrier of one or more than one treatment agent as the two types of carriers will provide different pharmacokinetic release profiles which may be advantageous for therapy.
In one embodiment, fibers can be electrospun from collagen and elastin dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFP), forming a polymer solution. A treatment agent can be added to the polymer solution. A surfactant and a stabilizer can be used to evenly disperse the treatment agent in the solvent. The polymer solution can then be loaded into a syringe and placed in a syringe pump for metered dispensing at a predetermined rate. A positive output lead of a high voltage supply can be attached to a needle on the syringe. The needle can be directed to a stainless steel grounded target placed approximately 10 cm from the needle tip, which can be rotated at a predetermined speed to ensure an even coating. The distance of the needle from the target can be varied depending upon the diameter of the fibers needed. The resultant microfibers are from about 0.5 μm to about 3 μm in diameter and the resulting non-woven mat of fibers can then be processed into smaller lengths of about 0.5 μm to about 500 μm.
In some embodiments, the sustained-release carrier is a liposome or a polymerosome. "Liposomes" are artificial vesicles that are approximately spherical in shape and can be produced from natural phospholipids and cholesterol. In one method, phospholipids are mixed with cholesterol in chloroform. Suitable phospholipids include, but are not limited to, dimyristoyl phosphatidyl choline or dipalmitoyl ethanolamine. In some embodiments, hydrophobic treatment agent can be added with an optional co-solvent, such as heptane or toluene. The liposomes may also be hydrophilically modified with an agent such as polyethylene glycol or dextran. After mixing, the solvent (and optional co-solvent) can be evaporated with heat or ambient temperature in a round bottom flask. Resultant lipids will be deposited on the glass surface. In some embodiments, hydrophilic treatment agent and water can be added to the flask and sonicated to form liposomes. The resultant suspension can be pressure filtered through ceramic pore size controlled filters to reduce liposome particle size. In the case of a polymerosome, a similar manufacturing technique can be used as that of a liposome. Polymerosomes can be formed from di-block co-polymers of differing solubility. For example, one block can be hydrophobic, e.g., poly lactic acid, polycaprolactone, n-butyl acrylate, and the other block can be hydrophilic, e.g., poly (ethylene glycol), poly(acrylic acid).
Matrix Systems
A biocompatible matrix system can be used to suspend the treatment agent or the treatment agent-infused sustained-release carrier for delivery to the infarct region. In some embodiments, the matrix system can be a one-component or a two-component gel. In some embodiments, the matrix system is a two-component gel. Two-component gels can include, for example, fibrin glues (e.g., two components comprising fibrinogen and thrombin), self-assembled peptides or alginate constructs.
In some embodiments, the matrix system is a one-component gel. An example of a one-component gel includes an acrylate agent that is biocompatible. The one-component gel serves in one aspect to disperse the sustained-release carrier in order to form a more uniform scaffold over the entire infarct zone and may include border zone as well. For example, the one-component gel may be sodium hyaluronate. The gel disperses the sustained-release carrier acting as a suspending media.
In some applications, the two-component gelation system includes a fibrin glue. Fibrin glue consists of two main components, fibrinogen and thrombin. Fibrinogen is a plasma glycoprotein of about 340 kiloDaltons (kDa) in its endogenous state. Fibrinogen is a symmetrical dimer comprised of six paired polypeptide chains, alpha, beta and gamma chains. On the alpha and beta chains, there is a small peptide sequence called a fibrinopeptide which prevent fibrinogen from spontaneously forming polymers with itself. In some embodiments, fibrinogen is modified with proteins. Thrombin is a coagulation protein. When combined in equal volumes, thrombin converts the fibrinogen to fibrin by enzymatic action at a rate determined by the concentration of thrombin. The result is a biocompatible gel which gelates when combined at the infarct region. Fibrin glue can undergo gelation at about 10 to about 60 seconds. Examples of other fibrin glue-like systems include, but are not limited to, Tisseel™ (Baxter), CoSeal™ (Baxter), Crosseal™ (Omrix Biopharmaceuticals, Ltd.), Hemaseel� (Haemacure Corp.) and CoStasis� (Angiotech Pharmaceuticals).
In some embodiments, the two-component gel comprises self-assembled peptides. Self-assembled peptides generally include repeat sequences of alternating hydrophobic and hydrophilic amino acid chains. The hydrophilic amino acids are generally charge-bearing and can be anionic, cationic or both. Examples of cationic amino acids are lysine and arginine. Examples of anionic amino acids are aspartic acid and glutamic acid. Examples of hydrophobic amino acids are alanine, valine, leucine, isoleucine or phenylalanine. Self-assembled peptides can range from 8 to about 40 amino acids in length and can assemble into nanoscale fibers under conditions of physiological pH and osmolarity. In sufficient concentration and over time, the fibers can assemble into an interconnected structure that appears macroscopically as a gel. Self-assembled peptides typically undergo gelation between several minutes to several hours. Examples of self-assembled peptides include, but are not limited to: AcN-RARADADARARADADA-CNH2 (RAD 16-II) wherein R is arginine, A is alanine, D is aspartic acid, and Ac indicates acetylation, sequence RARADADARARADADA may be referred to herein as SEQ ID NO: 1; VKVKVKVKV-PP-TKVKVKVKV-NH2 (MAX-1) wherein V is valine, K is lysine and P is proline, sequence VKVKVKVKV-PP-TKVKVKVKV may be referred to herein as SEQ ID NO: 2; and AcN-AEAEAKAKAEAEAKAK-CNH2 wherein A is alanine, K is lysine and E is glutamic acid (EAK16-II), sequence AEAEAKAKAEAEAKAK may be referred to herein as SEQ ID NO: 3.
In one example, the self-assembled peptide is RAD 16-II. At low pH and osmolarity, RAD 16-II forms a solution. At physiological pH and osmolarity, RAD 16-II forms a gel although gel formation can be slow. In some embodiments, RAD 16-II is mixed with phosphate buffer saline (PBS) to form a first component solution. In some embodiments, the first component solution can be co-injected with a second component comprising sodium chloride, sucrose or other osmolarity modifying substance using, for example, a dual-injection delivery assembly. In some embodiments, the components can be co-injected with carriers such as angiogenesis promoting factors, cell survival promoting factors and/or endogenous recruiting factors. These factors bind non-specifically to the self-assembled peptides by electrostatic interactions, and this binding can control or retard the release of the factors.
In some embodiments, the two-component gel is an alginate construct. For example, the alginate construct may be collagen or gelatin grafted alginate. In one example, a first component can be a solution of about 0.5 percent to about 1.0 percent alginate while a second component can be a solution of about 40 mM to about 180 mM calcium chloride. One example of a suitable amount of components is about 200 microliters of alginate solution and about 200 microliters of calcium chloride. In one embodiment, a desired amount of a treatment agent may be introduced with the alginate solution.
Methods of Manufacture
In one embodiment, collagen electrospun fibers can be processed to a range from about 200 nm and about 1300 nm. The range of electrospun fibers is approximately the range of naturally occurring type 1 and type 3 fibers which make up the heart matrix. Thus, the electrospun fibers may mimic endogenous fibers and accelerate growth of repair tissue to the infarct region, in particular, on the heart. The fibers can be dispersed throughout one component of a two-component gel. The two components can then be delivered to myocardial infarct region. The fibers can provide "docking sites" for endogenous myocardial stem cells and encourage their differentiation into cardiomyocytes. The gel can provide temporary containment of the fibers and prevent premature removal by macrophage cells.
The fibers can be fabricated such that they include an agent or no agent. Examples of agents can include a chemoattractant, such as SDF-1, or a cell survival promoting factor, such as IGF-1. In one embodiment, SDF-1 may be incorporated within the electrospun fibers and the resultant agent infused electrospun fibers may be dispersed throughout one component of a two-component gel. When delivered, the release of SDF-1 may recruit endogenous stem cells to the infarct region where they will adhere to the electrospun fibers and differentiate into stem cells.
In another embodiment, IGF-1 may be incorporated within the electrospun fibers and the resultant agent infused electrospun fibers may be dispersed throughout one component of a two-component gel. Stem cells may be incorporated within the other component of the two-component gel. When delivered, the stem cells may be temporally immobilized in the gel and adhere to the electrospun fibers. IGF-1 may enhance stem cell survival.
It should be appreciated that any of the above-described methods may be combined to treat an infarct region.
Methods of Treatment
Devices which can be used to deliver each component of the gel include, but are not limited to, dual-needle left-ventricle injection devices and dual-needle transvascular wall injection. Methods of access to use the injection devices include access via the femoral artery or the sub-xiphoid. "Xiphoid" or "xiphoid process" is a pointed cartilage attached to the lower end of the breastbone or sternum, the smallest and lowest division of the sternum. Both methods are known by those skilled in the art.
In one embodiment, delivery assembly 400 includes main needle 420 disposed within delivery lumen 430. Main needle 420 is movably disposed within delivery lumen 430. Main needle 420 is, for example, a stainless steel hypotube that extends a length of the delivery assembly. Main needle 420 includes a lumen with an inside diameter of, for example, 0.08 inches (0.20 centimeters). In one example for a retractable needle catheter, main needle 420 has a needle length on the order of 40 inches (1.6 meters) from distal portion 405 to proximal portion 415. Lumen 410 also includes separate, possibly smaller diameter, auxiliary lumen 440 extending, in this example, co-linearly along the length of the catheter (from a distal portion 405 to proximal portion 415). Auxiliary lumen 440 is, for example, a polymer tubing of a suitable material (e.g., polyamides, polyolefins, polyurethanes, etc.). At distal portion 405, auxiliary lumen 440 is terminated to auxiliary needle end 450 co-linearly aligned with a delivery end of needle 420. Auxiliary lumen 440 may be terminated to auxiliary needle end 450 with a radiation-curable adhesive, such as an ultraviolet curable adhesive. Auxiliary needle end 450 is, for example, a stainless steel hypotube that is joined co-linearly to the end of main needle 420 by, for example, solder (illustrated as joint 455). Auxiliary needle end 450 has a length on the order of about 0.08 inches (0.20 centimeters).
Referring to
The proximal end of main needle 420 includes adaptor 470 for accommodating a substance delivery device (e.g., a component of a two-component bioerodable gel material). Adaptor 470 is, for example, a molded female luer housing. Similarly, a proximal end of auxiliary side arm 460 includes adaptor 480 to accommodate a substance delivery device (e.g., a female luer housing).
The design configuration described above with respect to
In one embodiment, catheter assembly 500 is defined by elongated catheter body 550 having proximal portion 520 and distal portion 510.
Guidewire cannula 570 is formed within catheter body (from proximal portion 510 to distal portion 520) for allowing catheter assembly 500 to be fed and maneuvered over guidewire 580. Balloon 530 is incorporated at distal portion 510 of catheter assembly 500 and is in fluid communication with inflation cannula 560 of catheter assembly 500.
Balloon 530 can be formed from balloon wall or membrane 335 which is selectively inflatable to dilate from a collapsed configuration to a desired and controlled expanded configuration. Balloon 530 can be selectively dilated (inflated) by supplying a fluid into inflation cannula 560 at a predetermined rate of pressure through inflation port 565. Balloon wall 335 is selectively deflatable, after inflation, to return to the collapsed configuration or a deflated profile. Balloon 530 may be dilated (inflated) by the introduction of a liquid into inflation cannula 560. Liquids containing treatment and/or diagnostic agents may also be used to inflate balloon 530. In one embodiment, balloon 530 may be made of a material that is permeable to such treatment and/or diagnostic liquids. To inflate balloon 530, the fluid can be supplied into inflation cannula 560 at a predetermined pressure, for example, between about one and 20 atmospheres. The specific pressure depends on various factors, such as the thickness of balloon wall 335, the material from which balloon wall 335 is made, the type of substance employed and the flow-rate that is desired.
Catheter assembly 500 also includes substance delivery assembly 505 for injecting a substance into a myocardial infarct region. In one embodiment, substance delivery assembly 505 includes needle 515 a movably disposed within hollow delivery lumen 525 a. Delivery assembly 505 includes needle 515 b movably disposed within hollow delivery lumen 525 b. Delivery lumen 525 a and delivery lumen 525 b each extend between distal portion 510 and proximal portion 520. Delivery lumen 525 a and delivery lumen 525 b can be made from any suitable material, such as polymers and copolymers of polyamides, polyolefins, polyurethanes and the like. Access to the proximal end of delivery lumen 525 a or delivery lumen 525 b for insertion of needle 515 a or 515 b, respectively is provided through hub 535. Delivery lumens 525 a and 525 b may be used to deliver first and second components of a two-component gel composition to a myocardial infarct region.
From the foregoing detailed description, it will be evident that there are a number of changes, adaptations and modifications of the present invention which come within the province of those skilled in the part. The scope of the invention includes any combination of the elements from the different species and embodiments disclosed herein, as well as subassemblies, assemblies and methods thereof. However, it is intended that all such variations not departing from the spirit of the invention be considered as within the scope thereof.
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Body Solid Tools Solid Tricep Pressdown Bar with Rubber Grip
by Body Solid Tools | Item #: 767715 | Model #: MB504RG |
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About this item
Designed for maximum triceps contraction.
Pro-Grip Triceps Press Down Bar. Designed for maximum triceps contraction. Heavy-duty, solid steel welded flange allows maximum load capacity. Dual knurl-textured grips and polished round end plates ensure a comfortable no-slip grip. Solid steel, 6 lbs.
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Michael Morsovillo
Director of Transfer Admission
Phone number:
(708) 524-6793
High School:
Marist High School
Saint Xavier University
B.A. in English; M.A. in English Literature
Why I work in DU admission:
After nearly 18 years at Dominican, I can still feel the spirit and energy of the place – it's truly rewarding to serve the transfer and adult population and encourage them to experience the same sense of community that exists at Dominican. Working in college admission allows me to assist others in fulfilling their dreams, and I'll always appreciate that the most.
Favorite Foods:
Lasagna, Shrimp and Lobster, anything chocolate
Reading, Writing, Playing Guitar
On a day off I enjoy:
Spending quality time with my wife Debbie
Transfer students (A-D), international and post-baccalaureate students.


text:
FIG. 1 is a bottom perspective view of an outsole for a shoe in accordance with my new design;
FIG. 2 is a bottom view thereof;
FIG. 3 is a left side view thereof;
FIG. 4 is a right view thereof;
FIG. 5 is a front view thereof;
FIG. 6 is a rear view thereof;
FIG. 7 is an enlarged perspective view of the area labeled "7" in FIG. 1; and,
FIG. 8 is a cross sectional view thereof, taken along the lines 8—8 in FIG. 7.
The broken lines showing the interior and upper edge of the fragment in FIG. 8 illustrate the portion of the design that forms no part of the claim.


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Hang tight!
Recipe by BINGADING
"This is a savory vegetable soup that permeates a wonderful aroma. Perfect for those brisk fall days. Serve with crusty bread. For a vegetarian soup, substitute vegetable broth for the chicken broth."
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4 tablespoons
olive oil
2 cups
chopped onion
1/2 cup
chopped celery
2 cloves
garlic, crushed
2 cups
diced peeled sweet potatoes
2 teaspoons
1 teaspoon
ground turmeric
1 teaspoon
dried basil
1 teaspoon
1 pinch
ground cinnamon
1 pinch
cayenne pepper
bay leaf
3 cups
chicken stock
1 tablespoon
1 cup
chopped fresh tomato
1 1/2 cups
cooked garbanzo beans
3/4 cup
chopped green bell pepper
Yum... loads of veggies and it tastes great too! I am not good at estimating how amounts of veggies translate into cups of ingredients, so I bought too much produce at the store. I learned from it though and hopefully this info will help others: 2 c. sweet potatoes = two smallish sweet potatoes; 2 c. onion = 1 yellow onion; 1/2 c. celery = 3 stalks; 1 c. tomato = 2 small tomatoes (the little ones that come on the vine); 3/4 c. gr. pepper = about 2/3 of a regular green pepper. Woo hoo!
This soup wasn't bad; but it wasn't great either. A little disappointing after all the great reviews.
206 Ratings
Definitely double the stock. I skipped the saute step and just put all ingredients in the crock pot on low for 8 or so hours. The house smelled wonderful and the soup was a huge hit with our guests. I doubled the sweet potato just because we enjoy it so much. I subbed soy sauce for tamari and left out the turmeric because I didn't have any. Easy and so satisfying on a cold January night!
I must say that the aroma was absolutely heavenly as this was cooking! My modifications: I cut the oil in half, I added the peppers in with the onions/garlic/sweet taters in the beginning, used a full can of garbanzo beans, cut the salt in half, and added an extra cup of broth (beef instead of chicken because it's what I had on hand). This is a very flavorful soup, and the spice combination is unique for a vegetable soup. Very delicious and I will make again, even in the dead heat of summer.
WOW this was so good. so so so good. It was very hearty and filling, the sort of soup that warms you to the core. Next time I make this I will use more sweet potatoes because they really shine here. I upped the broth to 4 cups. I couldn't find any good fresh tomatoes so I used a small can of diced tomatoes. I included the juice, which gave a really nice acidity to the broth. I really like that this soup lends itself easily to flexibility. People have added squashes, apples... I htink i'd like it with diced carrots. I will make it again, for sure, and maybe I'll get a little adventurous with the ingredient
this was awesome! I added some extra mixed beans, chopped cabbage and barley . The sweet potato is great in this soup. I made a huge pot and froze in containers to take to work for lunch- freezes beautifully and delish reheated!
OMG this is soooo yummy! My husband and I really enjoy Thai food, and he told me this is just like something we'd get there. I substituted the following and it is absolutely delicious and QUICK too!
1)1tsp Paprika, 1tsp ceyenne pepper (instead of 2tsp paprika)
2)curry instead of turmeric
3)1/2 tsp basil, 1/2 tsp oregano instead of 1tsp basil
4)no tamari
5)Instead of garbanzo beans, black beans
I added 2 cans of chicken breast to make it a whole meal.
A wonderful soup, we substituted soy sauce as we didn't have the tamari, also changed to another white bean as garbanzo's aren't our favorite..
Great taste, froze the leftover to take to lunch, was even better 2 weeks later!
hearty, spicy and a little sweet.. yumm
* Percent Daily Values are based on a 2,000 calorie diet.
Gypsy Soup
Serving Size: 1/10 of a recipe
Servings Per Recipe: 10
Amount Per Serving
Calories: 137
Calories from Fat: 56
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There are many ways the Division of Biostatistics and Epidemiology (DBE) can help you with your research needs, from formulating a sound idea and writing grant proposals to data management and analysis. We conduct our work with the highest clinical and ethical standards. We also offer hourly consultations and education and training for state-of-the-art research.
The Division of Biostatistics and Epidemiology, in collaboration with the Division of Biomedical Informatics and other units, is engaged in the development of a comprehensive Data Management Center (DMC). This effort is in keeping with the 2015 strategic plan's goal of creating and strengthening the research infrastructure to support the full spectrum of research at Cincinnati Children's Hospital Medical Center and to accelerate the impact on child health. The mission of the DMC is to improve clinical outcomes and research by leading the development of state-of-the-art data management. The DMC will strive to ensure that all clinical data at Cincinnati Children's are managed in accord with Good Clinical Data Management Practices, that the institution recruits the best and brightest data management professionals and that their training is conducted according to industry standards. To that end, the DMC will interact with other divisions, share the best clinical data management practices and disseminate the latest information on the subject. The science of data management continues to increase in complexity and today combines elements of clinical operations, compliance, information technology and biostatistics, among other disciplines.
The CCTST has established a single point of contact, called Research Central, which provides a "concierge" function to provide trainees, entry-level faculty and established faculty with little experience in clinical / translational research with resources in protocol development, biostatistical / bioinformatics support, regulatory compliance, support for investigational drug and investigational device exemption development and community-based research. This resource is especially recommended for small projects; the initial contact and services are provided by the CCTST free of charge. DBE faculty lend their expertise to the CCTST and Research Central. For more information, visit the CCTST website.
Investigators may request consultation for a defined number of hours, which DBE will charge according to a published "fee-for-service" schedule. The fees are established on the basis of the level of expertise required (e.g., faculty, staff statistician / epidemiologist, database programmer) and are aimed at recovering the cost of performing the service. This arrangement is appropriate for small projects (requiring ≤ 5 percent FTE support), and for projects that are not supported by extramural funding. For more information, contact us.
All DBE faculty and many staff members participate in sponsored research that is thematically coherent with their interests and expertise. It is critically important that statisticians and epidemiologists participate in research led by basic and clinical investigators at the earliest possible stages of development to ensure that the research questions are properly formulated and reflected in a valid study design, and that a strong data management and analysis plan is part of any application for research funding or research protocol. The expertise of DBE faculty covers a large array of research methods and subject-matter areas. Learn more about our division members and their areas of expertise.
DBE supports the world-class research of Cincinnati Children's by lending authoritative support to basic and clinical research programs and by providing outstanding education and training in statistical and epidemiologic research methods for students and professionals. We have entered broad agreements with several Cincinnati Children's institutes and divisions to ensure that adequate support is given to the development of research ideas, to the design of competitive grant applications, to the publication of rigorous analyses of research findings, and to the education and training of residents, fellows and junior faculty in specific research programs. For more information, contact us.
The Graduate Statistics Internship Program is an educational collaborative agreement with the Department of Mathematical Sciences at the University of Cincinnati. The aim of the program is to provide educational and research experiences to PhD graduate students in statistics. Students will learn to perform statistical consultation related to medical health research projects as well as to conduct method development, under the supervision of DBE faculty. Students are encouraged to conduct their dissertation research addressing health research questions. They will also have an opportunity to compete for a graduate scholarship award.
For more information about this program, contact Bin Huang at email@example.com or 513-636-7612.
DBE faculty support the educational mission of Cincinnati Children's to teach research methods to residents and fellows in pediatrics both in the classroom and online. DBE has developed six online learning modules of the fellowship core curriculum to meet the fellowship learning requirements set out by the American Board of Pediatrics and the Accreditation Council for Graduate Medical Education. These learning modules cover the basics on types of data, research design, statistical inference, causation, diagnostic tests, meta-analyses and clinical trials.
DBE also contributes to the educational mission of UC as its faculty members participate as instructors and guest lecturers in graduate programs in biostatistics and epidemiology offered by the Department of Environmental Health , including the master's program in clinical research promoted by the CCTST. Faculty also provide one-on-one teaching of biostatistical and epidemiologic research methods as an integral part of consultations with fellows and junior and senior faculty across campus. Most of our faculty routinely lend their expertise in support of NIH-funded K awards and other faculty development activities. For more information, contact us.
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text:
Hewitsons calls off merger talks
Posted: January 18, 2013|
Leading city law firm Hewitsons has called off merger talks with Veale Wasbrough Vizards.
Simon Heald, VWV managing partner, said: "We have enjoyed getting to know Hewitsons over recent months and confirm that our discussions have ceased.
"Our plans at VWV are ambitious and focused on growth as we further develop our sector approach on a national and regional level."
John Dix, managing partner of Hewitsons, said: "Our discussions with VWV were constructive and enjoyable throughout, but the merger is not going ahead.
"Both firms have impressive regional strengths and deep specialist expertise. We have wished each other well as we take these forward independently."


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11. Burr Ridge Veterinary Clinic
8120 South Cass Ave, Darien, IL 60561
"Building relationships through healthy pets" That's what we strive to do at Burr Ridge Veterinary Clinic. We are dedicated to making sure our clients feel welcomed, valued and connected to us as part of the Burr Ridge Veterinary Clinic family. All of our staff and doctors understand the bondview details hide details view deal
Services: Veterinarians, Declawing, Small Animal Vet, Veterinary Surgery, Animal Microchipping, Veterinary Euthanasia, Spaying/Neutering, Veterinary Dentistry, Veterinary Vaccinations, Animal Flea Control, Reptile Vet, Exotic Animal Vet, Veterinary Docking
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1007 Maple Avenue, Lisle, IL 60532
About Our Facility Ness Exotic Wellness Center is located at 1007 Maple Avenue, Lisle, IL 60532. This is just one (1) mile South of the previous facility. Similar to our former location, we are about 3/4 mile West of I-355 & 1/4 mile East of Route 53. Stop on by for a visit and to see it forview details hide details
Services: Animal Boarding, Spaying/Neutering, Small Animal Vet, Reptile Vet, Declawing, Veterinary Dentistry, Veterinary Euthanasia, Exotic Animal Vet, Veterinary Surgery, Holistic Veterinary Medicine, Veterinarians, Animal Microchipping, Bird Vet
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555 E. Glenwood-Lansing Road, Glenwood, IL 60425
Glenwood Village Pet Hospital understands the special bond that humans have with their pets. Our goal is to protect that bond by providing the highest quality care for your companion animals. You and your pets are a part of our family. Glenwood Village Pet Hospital is open six days a week,view details hide details view deal
Services: Veterinary Dentistry, Exotic Animal Vet, Veterinarians, Veterinary Vaccinations, Declawing, Veterinary Docking, Animal Boarding, Animal Flea Control, Veterinary House Calls, Animal Daycare, Animal Microchipping, Small Animal Vet, Veterinary Euthanasia, Spaying/Neutering, Veterinary Surgery, Animal Grooming, Reptile Vet, Bird Vet


text:
Signature Escapeshandcrafted experiences at insider prices you won't find anywhere else
Deluxe King Room
From $154/night
Only available through Luxury Link...
- Welcome cocktails, one per person
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- 30-minute pampering massage treatments, one per person
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Deluxe King Room
- 1 king bed, 350 square feet
- Private balcony and ocean, mountain or river view
Additional Information:
Private air transfers are available from Las Americas International Airport (SDQ) in Santo Domingo.
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Deluxe King Roomking bed, balcony, tropical jungle and ocean view
Deluxe Double Room2 full size beds, balcony, mountain and ocean views
Ocean View Suiteking bed, dining area and kitchenette, terrace and infinity pool
hotel info
Nearest Airport: BRX, SDQ


text:
November 18, 2011
Waitsburg-Prescott head coach Jeff Bartlow calms his team as they head into the quarterfinal round of football playoffs this weekend.
Stories this photo appears in:
Waitsburg-Prescott brings explosive offense to bear against Lind-Ritzville
W-P features two backs with more than 1,000 rushing yards this season.
WAITSBURG — 'We're explosive. That's the best way to say it."That's how Waitsburg-Prescott coach Jeff Bartlow summed up his undefeated football team while discussing W-P's state Class 2B-11 quarterfinal matchup with Lind-Ritzville/Sprague at noon Saturday
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My alarm went off at 2:45am this morning. I do believe that is what is referred to as the "butt crack of dawn." I have it all worked out: If I set the alarm for 2:45, I actually get up at 3. I throw on clothes, then change and feed my boy if I can… [read more]
BC o'D
May 22, 2010 by 6 Comments
The Perfect Lunch
May 8, 2010 by 2 Comments
It's a bold statement, I know. Sometimes, I take the time to pack a lunch and then, when 12:00 rolls around, I get all persnickety and want something else. And sometimes, the stars align and I find myself with exactly what I want, exactly when I want it. Ladies and Gentlemen, I bring you The… [read more]
Almond Date Cream: Take 2
May 7, 2010 by Leave a Comment
As mentioned in a previous post, I love almonds and I love dates, so I had to try the Almond Date Cream recipe in my new Vegan Planet Cookbook. (I think the book calls it Almond Butter Cream, but that didn't seem an accurate description to me.) The first time around, I couldn't resist modifying… [read more]