text:
This invention relates to carvedilol methanesulfonate, compositions containing this compound and methods of using carvedilol methanesulfonate to treat hypertension, congestive heart failure and angina.
1. A compound which is carvedilol methanesulfonate.
2. A pharmaceutical composition comprising the compound according to
3. A controlled release formulation comprising the compound according to
4. A delayed release formulation comprising the compound according to
5. A matrix formulation comprising the compound according to
6. An enteric coated formulation comprising the compound according to
7. A method of treating hypertension, congestive heart failure or angina which comprises administering to a subject in need thereof an effective amount of the compound according to
8. A process for the preparation of carvedilol methanesulfonate which comprises reacting carvedilol with an aqueous solution of methanesulfonic acid, with the acid being present at a 1:1 molar ratio.
This application claims the benefit of Provisional Application No. 60/165,545, filed Nov. 15, 1999.
This invention relates to a pharmaceutically active compound, compositions containing the compound and methods of using the compound in the treatment of certain disease states in mammals, in particular man. More specifically, the present invention relates to carvedilol methanesulfonate, which is the methanesulfonate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol, compositions containing this compound, and methods of using carvedilol methanesulfonate to treat hypertension, congestive heart failure and angina.
U.S. Pat. No 4,503,067 describes a compound which is known as carvedilol. This compound is a novel multiple action drug useful in the treatment of hypertension and angina. Carvedilol is known to be both a competitive non-selective β-adrenoceptor antagonist and a vasodilator. The vasodilatory actions of carvedilol result primarily from α1-adrenoceptor blockade, whereas the β-adrenoceptor blocking activity of the drug prevents reflex tachycardia when used in the treatment of hypertension. These multiple actions of carvedilol are responsible for the antihypertensive efficacy of the drug. Also, carvedilol, as a consequence of its antioxidant action in attenuating oxygen free radical-initiated lipid peroxidation, is useful in organ protection, in particular, cardioprotection. Additionally, carvedilol is useful in the treatment of congestive heart failure.
The currently marketed formulation of carvedilol is a conventional, swallow tablet and prescribed as a twice-a-day medication in the United States. This formulation is in immediate release form; that is to say the nature of the formulation is such that by the time carvedilol leaves the stomach, it is either in solution or it is in the form of a suspension of fine particles, i.e. a form from which carvedilol can be readily absorbed.
Carvedilol, a free base with one pKa of 7.6, exhibits a predictable solubility behavior in neutral or alkaline media, i.e. above pH 9.0, the solubility is relatively low (<1 ug/mL). The solubility increases with decreasing pH and eventually reaches a plateau with a broad peak (˜0.2 mg/mL) at a pH of 4-5. At acidic pHs of 1 to 4 in buffers, the solubility is limited by the solubility of the protonated form of carvedilol or its salt formed in-situ. The hydrochloride salt form formed in-situ in an acidic medium, such as simulated gastric fluid, is less soluble in water than carvedilol itself.
Surprisingly, it has been found that unlike carvedilol or certain salt forms of carvedilol, carvedilol methanesulfonate exhibits a solubility of >8.0 mg/ml in purified water at 25░ C. Thus, carvedilol methanesulfonate may result in a dosage form from which the drug substance becomes available for bioabsorption throughout the gastrointestinal tract. Hence, it may be possible to develop controlled release once-a-day (uid) and twice-a-day (bid) dosage forms, delayed release or pulsatile release dosage forms. Also, carvedilol methanesulfonate may be formulated in an injectible form or as a transdermal patch. The high solubility feature of carvedilol methanesulfonate is particularly important when formulating this compound for therapeutic use.
The present invention provides a novel salt form of carvedilol, namely carvedilol methanesulfonate.
The present invention also provides pharmaceutical compositions containing carvedilol methanesulfonate and the use of this compound in the treatment of hypertension, congestive heart failure and angina.
and is claimed in U.S. Pat. No. 4,503,067 (assigned to Boehringer Mannheim, GmbH, Mannheim-Waldhof, Fed. Rep. of Germany), issued Mar. 5, 1985. Reference should be made to said patent for its full disclosure, including the methods of preparing and using this compound. The entire disclosure of the '067 patent is incorporated herein by reference.
In accordance with the present invention, it has been unexpectedly found that a novel salt form of carvedilol, namely the methanesulfonate salt, exhibits a significantly higher aqueous solubility than the corresponding free base or other prepared salts. The aqueous solubility data for carvedilol and its salt forms determined at 25░ C. are presented in Table 1.
The data from Table 1 demonstrates that the methanesulfonate salt of carvedilol exhibits an aqueous solubility in excess of 8 mg/ml, while the hydrochloride, adipate and tartrate salt forms are poorly soluble in water. Thus, the methanesulfonate salt of carvedilol provides for the development of bioenhanced dosage forms and patient-compliant injectible dosage forms.
Carvedilol methanesulfonate salt form can be formulated in accordance with the present invention in an injectible form, an oral solid dosage form (as an immediate release or modified release [i.e. controlled release, delayed release or pulsatile release] capsule or tablet) or as a transdermal patch, in particular, in pharmaceutical compositions for the treatment of congestive heart failure, hypertension and angina.
By controlled release is meant any formulation that achieves slow release of drug over an extended period of time. In the controlled release formulations of the instant invention, a portion of the carvedilol methanesulfonate in the formulation is made available as a priming dose and the remainder is released in a sustained fashion. Examples of controlled release systems are a matrix tablet or bead formulation, and a barrier film coated tablet or bead/pellet formulation.
By delayed release is meant any formulation wherein the release of the drug is delayed for certain time or minimum under acidic conditions but rapid above a certain pH depending on the polymer used for the barrier film coat. Examples of delayed release systems include timed-release tablets and capsules and enteric-coated tablets and beads.
By pulsatile release is meant any multi-unit tablet or capsule formulation where in individual mini-tablets or particulates/pellets/beads are polymer barrier film coated, that utilizes intermittent pulsatile dosings of carvedilol methanesulfonate from one or more units as a function of time.
Such modified release formulations are preferably formulated in a manner such that release of carvedilol methanesulfonate is affected predominantly during the passage through the stomach and the small intestine to the colon.
Examples of controlled release, pulsatile release and delayed release formulations which are suitable for incorporating carvedilol methanesulfonate are described in:
Sustained Release Medications, Chemical Technology, Review No. 177, Ed. J. C. Johnson, Noyes Data Corporation (1980);
Controlled Drug Delivery, Fundamentals and Applications, 2nd Edition, Eds. J. R. Robinson, V. H. L. Lee, Mercel Dekkes Inc., New York (1987);
Remington's Pharmaceutical Sciences, 16th Edition, Ed. A. Osol, Mack Publishing Company (1980); and
Solubility Considerations and Design of Controlled Release Dosage Forms, by G. M. Venkatesh, Polymer Preprint, Volume 40, pp 322, 1999 (American Chemical Society).
The process for preparing the solid dosage forms in accordance with the present invention may be carried out using a combination of a planetary mixture, a V-blender, a high shear granulator, a fluid bed granulator, a slugging press, a roller compactor, a cummunuting mill, sieving equipment, or a tableting machine. Optionally, the granulation of the hydrated or anhydrous form of carvedilol methanesulfonate, produced using a conventional dry or wet granulating equipment, is suitable for the preparation of immediate or modified release dosage forms. The preferred unit dosage forms include tablets or capsules. The compositions of this invention may be formulated by conventional methods of admixture such as blending, filling and compressing. Suitable pharmaceutically acceptable carriers for use in this invention include diluents, fillers, binders and disintegrants. An intra-venous formulation is prepared by methods known in the industry.
Immediate and modified release matrix beads may be manufactured using a extrusion-spheronization system. A wet granulated mass suitable for extrusion is prepared by blending the drug, a binder and a diluent or a matrix forming polymer, processing through a extrusion-spheronization system and collecting beads of a desired size fraction. The release profiles of the drug from these beads may further be modified by applying a barrier film coat. A buffer-based membrane-coated bead formulation may also be manufactured by a slurry-coating process as discussed in Pharmaceutical Development and Technology, Volume 3, pp 477-485 (1998). Alternately, transdermal patches for administration of carvedilol methanesulfonate through the skin at a predetermined rate can also be manufactured.
Any combination of pharmaceutically acceptable excipients, e.g. buffers, carbohydrates, diluents, fillers, binders and disintegrants, in desired proportions may be utilized in accordance with the wet or dry granulation process or direct compression formulation of the present invention. The excipients commonly used in pharmaceutical industry are well described in the literature [refer to the Handbook of Pharmaceutical Excipients, A. Wade and P. J. Weller (Editors), American Pharmaceutical Association (1994)]. Pharmaceutically acceptable fillers and diluents include, but are not limited to, the following: lactose (hydrous as well as anhydrous), starch [unmodified (corn starch) or modified (for example, Starch 1500 available from Colorcon)], sucrose, mannitol, sorbitol, cellulose, inorganic sulfates and phosphates. Disintegrants include, but are not limited to, the following: sodium starch glycolate, sodium carmellose and crosslinked polyvinyl pyrrolidone, and binders include, but are not limited to, the following: gelatin, corn starch, modified starch (Starch 1551, pregelatinized starch), hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose (HPC), sodium carboxy methyl cellulose, alginic acid, acacia, etc. Examples of excipients suitable for modified release applications include, but are not limited to, the following: high molecular weight HPMCs, polymethacrylate polymers known as Eudragits, polyethylene oxide, Polyox« (Union Carbide Corporation), modified ethyl cellulose, Surelease« (Colorcon), crosslinked acrylic acid polymers, Carbopol« (BF Goodrich Speciality Chemicals) and waxy materials, such as glyceryl behenate (Compritol«, glyceryl palmitostearate (Precirol«), and Gelucires« [all from Gattefosse s.a., France] and carnauba wax.
The matrix formulations of the present invention may be prepared using three types of materials: insoluble plastics, hydrophilic polymers or fatty compounds. Plastic matrices include methyl acrylate-methacrylate, polyvinyl chloride and polyethylene. Hydrophilic polymers include methylcellulose, hydroxypropylmethylcellulose (HMPC) and sodium carboxymethylcellulose. Fatty compounds include various waxes such as carnauba wax and glyceryl tristearate. The most common method of preparation is to mix carvedilol with the matrix material and then compress the mixture into tablets. In the case of wax matrices, carvedilol is generally dispersed in molten wax, which is then congealed, granulated and compressed into cores. In the matrix formulation containing carvedilol, the priming dose (the portion of the carvedilol that is immediately available in the formulation) is placed in a coat of the tablet. The coat can be applied by press coating or by conventional pan or air suspension coating.
Delayed release formulations containing carvedilol methanesulfonate may be prepared either by coating particles or granules or tablets with enteric polymers which are resistant to acids but soluble at alkaline pHs. Examples of enteric polymers are hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate or butyrate, polyvinyl acetate phthalate, Eudragit L and S polymers. Thus, the release of carvedilol methanesulfonate can be controlled by adjusting the thickness of the barrier coat and/or by a proper choice of the enteric polymer. The coated particles can be filled into capsules or optionally compressed into tablets.
The present invention also provides for various combinations of immediate release and controlled release forms. For example, the uncoated sustained release matrix core may be in combination with an immediate release form of carvedilol methanesulfonate and/or a coated matrix form. The matrix core may be comprised of a multitude of pellets coated independently with different release-delaying substances, all of which may be combined with uncoated or immediate release forms of carvedilol methanesulfonate.
The present invention provides a method of treating hypertension, angina and congestive heart failure by administering an effective amount of an immediate release or controlled release or delayed release formulation containing carvedilol methanesulfonate, or a combination thereof, for treating hypertension, angina and congestive heart failure. The formulations of the instant invention may also be used in organ protection, for example, in cardioprotection.
The following examples are illustrative of the instant invention. These examples are not intended to limit the scope of this invention as defined hereinabove and as claimed hereinbelow.
In Examples 2-5, below, the term "internal granules" means the granulation obtained by blending and granulating ingredients (drug substance and excipients) by a wet or dry granulation process.
Preparation of carvedilol methanesulfonate: Carvedilol was suspended in an aqueous solution of methanesulfonic acid, with the acid being present at a 1:1 molar ratio. The suspension is vortexed during the addition of carvedilol powder. After storage of the suspension for 6-15 hrs, the suspension is filtered and the solid residue is dried.
56.0 parts of carvedilol methanesulfonate, 40 parts of powdered mannitol and 4.0 parts of pregelatinized starch (Starch 1551), a binder are granulated in a planetary mixer using purified water as the granulating agent. The moist granulation is wet milled and dried using a fluid bed drier or an appropriate drying device. The dried granulation is milled to produce granules passing through a #30 mesh or appropriate size sieve. Compression mixes with ingredients as listed in Formulas 1 and 2 are prepared by blending and compressed into 30.0 mg (as carvedilol free base) tablets with a tensile strength in the range of 3-10 kP using a tablet press. Tablets of Formulas 1 and 2 disintegrate in less than 2 minutes when tested in purified water at 37░ C.
56.0 parts of carvedilol methanesulfonate, 40 parts of fumaric acid and 4.0 parts of PVP, a binder, are dry granulated using a chilsonator, a Fitzmill and sieve-shaker to produce granules passing through a #30 mesh or appropriate size sieve. Compression mixes with ingredients as listed in Formulas 3 and 4 are prepared by blending and compressed into 30.0 mg tablets of hardness in the range of 5-10 kP using a tablet press.
56.0 parts of carvedilol methanesulfonate, 32.0 parts hydroxypropylmethyl cellulose (Methocel E4M, from Dow Chemical Co.), 8.0 parts of Methocel E15LV, 4.0 parts crosslinked polyvinylpyrrolidone (Crospovidone) and 4.0 parts of pregelatinized starch (Starch 1551), a binder are granulated in a planetary mixer using purified water as the granulating agent. The moist granulation is wet milled and dried using a fluid bed drier or an appropriate drying device. The dried granulation is milled to produce granules passing through a #30 mesh or appropriate size sieve. A compression mix is prepared by blending 68.7 parts of the granulation and 0.8 part of magnesium stearate and compressed into 30.0 mg tablets releasing the drug at a predesigned fashion.
Modified Release Formulations
80.0 parts of carvedilol methanesulfonate, 5.0 parts of hydroxypropylmethyl cellulose, and 15% glyceryl behenate (Compritol) are blended, roller compacted, milled using a Fitzmill milled to produce granules passing through an appropriate size sieve. Compression mixes with ingredients as listed in Formulas 5 and 6 are prepared by blending and compressed into 30.0 mg tablets. Tablets of Formula 6 disperse rapidly in the dissolution medium or on oral administration, and the drug is released from the granules over a long period.
Tablets of Formulas 1 and 2 are applied a membrane barrier coat using Eudragit RL polymer to provide for a long lasting release profile. Tablets of Formulas 3 and 4 are provided with an enteric coat using Eudragit L30D to produce delayed release dosage forms. A seal-coat and an over-coat are optionally applied to the tablets of these formulations.
80 parts of carvedilol methanesulfonate, 10 parts microcrystalline cellulose and 10 parts of Povidone (PVP) are granulated, extruded and spheronized using microcrystalline cellulose for dusting. Dried beads of a desired size fraction are also coated with a Surelease formulation to provide a barrier membrane of different thicknesses. Uncoated and coated beads at desired proportions are filled into hard gelatin capsules.
Non-pareil sugar seeds are layered with carvedilol methanesulfonate by slurry coating in a fluid bed granulator a suspension of the drug and talc in an aqueous Povidone solution. The pellets are hot melt coated with a waxy formula listed below, and cured for 12 hrs at 40░ C.
It is to be understood that the invention is not limited to the embodiments illustrated hereinabove and the right is reserved to the illustrated embodiments and all modifications coming within the scope of the following claims.
The various references to journals, patents, and other publications which are cited herein comprise the state of the art and are incorporated herein by reference as though fully set forth.
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Karting Seat, Carbon Fibre & Kevlar
Rib Tect Carbon Fibre Seat
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The Ribtect Original Carbon-Fiber Seat
Click here for sizing: http://www.ribtect.com/pdf/ribtect_seat_chart.pdf
In a race kart, one of the main chassis tuning components is the go-kart seat. Because a go-kart has no suspension, the chassis itself must flex for the kart to corner correctly. This flex also goes through the seat. If a seat is too stiff, it will not allow the chassis to flex properly. This can cause a chassis to "bind up" which will slow you down.
Because of many years of karting experience, I created a unique lay-up with materials that I thought would allow for better chassis performance. The idea was to add an "X-pattern" in the lay-up of the seat. I use 6" uni-directional carbon fiber strips to connect the seat from corner to corner. Then, the rest of the seat is laid up with composite fiberglass, allowing for more cross-flex than any other racing seat on the market.
The idea is this... When a sprint or road race kart rolls into a left hand corner, the inside rear tire must lift up off the ground to allow the kart to turn without scrubbing speed. When this happens, the upper left portion of the seat is flexed toward the lower right portion of the seat. This "cross flex" in the seat will hold energy, like a leaf spring until the chassis "unloads" off of the corner. When the chassis unloads, it is assisted with the energy stored in the "X pattern" of the seat. This will allow for a better feel into the corner and a better launch off of the corner. Most of the time, allowing for faster lap times.
The Ribtect Seat is unique in shape and unique in lay-up. There are countless hours in the design of this seat and countless laps, race after race, to find the best possible lay-up / flexibility. We have been known to make "custom" seats for customers looking for more chassis tuning tools. We can make a seat very soft and flexible, which may work very well for some chassis in some conditions. Or we can make a seat very stiff to work well with other chassis in various conditions.
Comfortable hand crafted shape, Carbon fiber / fiberglass construction, Two 6" strips uni-directional carbon fiber forming an X-pattern in the seat, Two extra layers of carbon fiber reinforcements in four mounting points, Two extra layers of carbon fiber on the bottom where seat might scrape, Shape and depth of the seat spreads the load and shock over a larger area, No shallow edge to dig into your ribs, Gives driver better feel for chassis, Lowers fatigue level.
To Prevent Rib Injury
The Ribtect Seat is designed to reduce the amount of rib injuries to karters. Thus, keeping more people involved and happy with the great sport of karting.
To Improve Performance
The Ribtect seat helps the chassis and driver to work better. Keeping the kart rolling free and providing a better launch out of the turns. Connecting more of the kart to the driver for a better feel of the chassis. Lowering the fatigue level of the driver, allowing for better concentration and improved consistency and lower lap times.
To Use The Best Materials
We designed the Ribtect Seat with the best materials possible. With a shiny black finish, the seat looks nice and is extremely durable.
FRP and Carbon Fiber Construction
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Harbour Grand Hong Kong
- Free WiFi
Main amenities
- 828 guestrooms
- 4 restaurants
- Full-service spa
- Outdoor pool
- Rooftop terrace
- Free area shuttle
- Health club
- Valet parking
- Business center
- Airport shuttle
- Childcare
- 24-hour front desk
What's around
- In North Point
- Tin Hau Temple (0.6 mi / 1 km)
- Times Square Shopping Mall (1.3 mi / 2.2 km)
- Happy Valley Race Course (1.5 mi / 2.4 km)
- Hung Hom Star Ferry Pier (1.7 mi / 2.7 km)
- Victoria Park (0.6 mi / 1 km)
Very good
It's very nice hotel. The breakfast buffet and outdoor poor are excellent! The…
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Hotel Info: 866-539-8117from $122
- Premier Harbour View Room
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- Premier Suite, Harbor View
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At a glance
Key facts
Hotel size
- This hotel has 828 rooms
- This hotel is arranged over 41 floors
- 24-hour check-in
- Check-out time is Noon
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Children (11 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Babysitting/childcare *
- Pets not allowed
- Free WiFi and wired Internet access in rooms
- Airport shuttle at scheduled times *
- No parking
- Valet parking *
- Accessible parking
- Free area shuttle within 5 km
In the hotel
- 4 restaurants
- Bar/lounge
- Coffee shop/café
- 24-hour room service
- Outdoor pool
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- Full-service spa
- Spa treatment room(s)
- Health club
- Sauna
- Business center
- Conference space
- Meeting rooms 2
- 24-hour front desk
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- Year Built 2009
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- Safe-deposit box at front desk
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In the room
- Climate control
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Special features
The onsite spa has massage/treatment rooms. Services include massages, facials, body wraps, and body scrubs. The spa is equipped with a sauna and a steam room. A variety of treatment therapies are provided, including aromatherapy and Ayurvedic.
DiningLe 188 Restaurant - This restaurant serves lunch and dinner.
Kwan Cheuk Heen - This restaurant specializes in Chinese cuisine and serves lunch and dinner.
Harbour Grand Cafe - This poolside restaurant specializes in international cuisine and serves breakfast, lunch, and dinner.
Nagomi - This restaurant specializes in Japanese cuisine and serves lunch and dinner.
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- The property is a member of Preferred Hotels & Resorts.
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The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Optional extras
Valet parking costs HKD 300 per day
Rollaway beds are available for HKD 600 per night
Airport shuttle service is offered for an extra charge of HKD 150 per person (roundtrip)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
Speech Difficulties
The most common speech problems seen in MS are dysarthria and dysphonia. Dysarthria involves speech that is slurred or poorly articulated; it can involve a loss of volume control, unnatural emphasis on words or sentences, and a slower rate of speaking. Dysphonia results in changes in the quality of speech, such as a breathless quality to the voice, or speech that sounds harsh.
A speech therapist can help with exercises and adaptive equipment, depending on the type of problem you are experiencing.
Non-Pharmacologic Management
Some exercises can strengthen and improve the muscles involved in the production of speech, or improve breathing through relaxation of the affected muscles.
Modifying Speech Patterns
A speech language therapist can teach techniques to help slow speech so that it is more understandable, as well as techniques such as improving the way words are articulated and correctly pausing between words. One technique that is particularly helpful is to listen to your own voice using a tape recorder.
Alternative Speech Production
When speech difficulties are severe and cannot be corrected with exercise or speech modification, alternative means of speech production can restore the ability to communicate. These range from technology that amplifies the voice, to alternative communication systems such as computer boards.
Pharmacologic Management
No medications can specifically improve speech difficulties. However, medications that relieve symptoms such as spasticity may provide some improvement.
|Last Updated on Wednesday, 16 October 2013 13:06


text:
That's a painful looking hit.
Printable View
That's a painful looking hit.
Hey gang.
I don't agree with going for it on 4th and 1.
Going for it on 4th and inches...ok, but 4th and a good 1? No way. Take the points on the road.
I think the mentality was trying to keep it out of the hands of Cribbs.
Let's do Colt a favor and spend a long time on offense. It's the humane thing really.
Time for work offense
let's go offense, get some points, rest the D and get outta there
If Seneca Wallace is a poor man's Tarvaris Jackson... could we still lose to him? Honest question.
Also, this Browns offense looks like Billick Ball.
Seneca Wallace is a more dangerous QB than Colt McCoy. The game just got harder to win
Good field position. Gotta take advantage and get points.
anybody have a good link for a stream they can message me? I'm using firstrowsports site, but their links are terrible this week
ray rice is running at will
If you guys remember, he played for the Browns in last year's home game.
We squeaked out a 24-17 game.
Goddamn Ray has great balance. I forsee him having an absolute monster game.
Rice is gonna have a big day.
This looks like the NE playoff game plan...
could've got a big on there
Wow. Cleveland's run defense is really bad.
Keep it rocking Ravens.....
god dammit cam no reverses


text:
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- Melithar's Stolen Bags
- Quest Item
Melithar's Stolen Bags can be found around grell camps in Shadowglen.
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This item is an objective of [3] Demonic Thieves.
Patch changes Edit
- Patch 4.0.3 (15-Nov-2010): Added.
External links Edit


text:
StillFreeTagger's's Gamespot Rank
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This emblem shows that you got into GameSpot's Greatest Game Hero competition on the ground floor by voting for the 10 additional characters added to the main list. Rock the vote!
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Hey, everyone's got to start somewhere. These loyal minions created a bracket to guess at who is the most vile of them all. Let's hope they don't get caught betting against their overlords!
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Hi, this achievement is all about ninjas, REAL NINJAS. This achievement is awesome. I followed a game announced at E3 2011 during the week of E3 and inherited REAL ULTIMATE POWER.
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Have you seen my bracket, bro? It's straight baller! This user predicted the greatest sidekick and created a bracket. Let the bropacalypse begin!
Hey look, it's a totally original dude wearing armor. With a huge gun and a helmet (a visor?). And he's riding a unicorn. This user was granted this magical emblem for not having any of their user profile images hosted on untrusted websites during The Great Purge of March 2013.


text:
Live the adventure!
Studies show that many men-and more and more women too-will not
even set foot inside a church today. Way too much of church
is boring and irrelevant. Many of us feel like we don't have
time. We don't want to be constantly asked for money. And frankly,
many of us believe church is for wimps. Beyond all that, the
number one reason most of us don't like to go to church is
obvious-there are way too many hypocrites there!
If you hate going to church, CrossWalk was built with you in
mind. At CrossWalk we're casual in our approach, yet what we
have to communicate is extremely serious stuff. We strive to
make every message and every service relevant and applicable to
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you can come to church in your jeans, or your shorts (or even in
your jean shorts) and feel perfectly comfortable in one of our
services. Grab a cup of coffee and a bagel on your way in and
settle in for a high-octane hour of power-learning about God.
The early Christians were not lambs. They were
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of church CrossWalk is striving to become.
If you're looking for a church that will-
-then, we challenge you to check out CrossWalk!
Questions? Comments? Let us know.
Find out how to grow deep roots.


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DUNMORE –The 18 month old who fell into a sewer drain in Lackawanna County Saturday night is now listed in stable condition at Children's Hospital in Philadelphia.
Caution tape still blocks the sewer drain where the apparent accident happened. It has shaken the child's family and parents throughout the area.
"I was in shock actually. I had no idea that the drain system was exposed like that," said Kathleen Nazar of Dunmore.
Nazar was in Dunmore buying groceries and diapers before stopping by to see her own grandchild, and says this incident has upset her.
"As a grandmother, as a mother, all these things go through your head. It could have been us. It could have been anybody. It's a scary thing," said Nazar.
"I could not imagine being without any of my grandchildren if anything like this would happen I would be frantic," said Rosanne Jayne of Archbald.
Dunmore police said the boyfriend of the boy's mother was putting two children in the car Saturday night when the baby fell backwards into the drain hole.
The boyfriend frantically worked to rescue the toddler himself before emergency crews did. The Dunmore police chief said for now, they believe it was all an accident.
"Right now that's what it appears to be, but again that's something that we're still asking some questions about," said Chief Patrick Reese.
No charges have been filed, and police said they've noticed drains like this are very common throughout the Greenridge area.
This storm drain on the corner of Greenridge Street and Clay Ave. was just recently replaced. Police say this opening is eight inches wide and they could see how this is a problem.
"The only time I've ever looked at a storm drain is when storms arise to make sure they're not blocked or anything obstructing them in any way. Now we're starting to look at them a little differently," said Chief Reese.
As Michelle Statdtfeld of Jermyn loaded up three-month-old Landon into the car in Dunmore, she said it's sad this incident had to happen before these drains were given a closer look.
"It's very scary. They should have never been opened, to begin with. I mean, heaven forbid another child, or they run off, or they fall, or they trip. No matter how it happened it shouldn't have happened, at all," said Stadtfeld.
The Scranton Sewer Authority released a statement late Tuesday saying they will be cooperating fully with the investigation, but there aren't any immediate plans to change these storm drains.
Police said they will be questioning the mother's boyfriend again, hoping to confirm that this incident was indeed just an accident.