text:
Jan 16 2009
Cold and Blue
It's cold here. Cold, cold, cold, cold, cold. It's the kind of cold that requires us to keep a constant fire going in our fireplace, or our drafty house will become uncomfortable really quickly and my yoga pants will no longer serve me adequately.
It's the kind of cold that means I'm outside with the axe, breaking through the ice on Puddin's trough so she'll have water to drink. The kind of cold that makes Charlie want to "hold it" for days so he won't ever have to set foot outside.
And let me tell you, that dog can HOLD IT.
At least, I think he can hold it. I HOPE he can hold it. There might be a corner in my house I'm unaware of.
I'll have to check on that.
As for the "Blue" portion of the title of this post: In the last week I've watched the following movies or television shows: "Alpha Dog", "Terms of Endearment", "Sophie's Choice", and four episodes of "Intervention."
Now, "Terms of Endearment" and "Sophie's Choice" are obvious. They've been tear-inducing (sob inducing) mainstays in my list of All-Time Favorite Movies for years, and while the subject matter (cancer and the Holocaust, respectively) of both movies is very, very difficult, I'm comfortable enough with the movies to at least be able to appreciate their contribution to the cinematic world.
"Intervention", the TV series, is a slightly different story. It's a new addiction (strange choice of words, I realize) for me, and is often grueling and painful to watch. But in most cases, each episode ends with a triumph: an addict taking control of his life and successfully making it through rehab and remaining sober after the fact. Human interest victories get me every time.
Now. As for "Alpha Dog?" It was the last straw. It's a compelling movie, yes, one that's difficult for me to stop watching. But after I watch it, I feel:
Chewed up.
Spit out.
Bathed in Blackness.
If you have young sons, if you have young daughters, or if you have any hope in the future of civilized society, let this serve as a warning to you:
Do not watch the movie "Alpha Dog."
Thank you for your time.
And now, if someone could please send me several cases containing DVD's of the following shows, I'd be most appreciative:
The Brady Bunch
Gilligan's Island
Sesame Street
Mr. Rogers
Hee Haw
Dinah Shore
Dinah Shore is the key here. It may be only thing that pulls me out of this slump.
Peace, Love, and Hormones,
Pioneer Woman
559 Comments
cindy On Friday, January 16 at 6:13 pm
Ree, those pictures are gorgeous!! I feel the chill.
Sending you warm thoughts from AZ.
Mary Lou kemp On Friday, January 16 at 6:14 pm
Your photos are beautiful and I believe you when you say its cold…..the photos sure fit the weather. We are freezing here in PA too….its 10 deg. right now and the temp. will probably drop even more tonight.
I love love love 'Something's Gotta Give' with Jack Nicholson and Diane Keaton. Also very funny movie is Norbit with Eddie Murphy…my oldest grandson and I watched it about 3 or 4 times over the period of a week and it never failed to make us laugh.
Lori Kelly On Friday, January 16 at 6:14 pm
Where oh where are you tonight? Why did you leave me here all alone? I searched the world over and thought I found true love. You met another and puff you were gone.
Frosty On Friday, January 16 at 6:14 pm
love the blue in your pictures.. i am not much for tv altho i do watch hee haw..10* here in central Michigan and i keep thinking spring..
miss lila On Friday, January 16 at 6:18 pm
Go watch some funny kids videos at youtube. It always does the trick for me!
Love ya,
Miss Lila in Atlanta
Amy On Friday, January 16 at 6:21 pm
I hated Alpha Dog. A friend highly recommended it. And that? Was the last time I ever took his movie suggestions.
I'm watching Mamma Mia. Again. LOVE IT!
Pam D On Friday, January 16 at 6:24 pm
Dear cold, blue one,
Here in Georgia, I used the seat warmer in my van for the very first time EVER this morning, and I've had the van since 2003. The thermometer on my front porch said 5 degrees, and in Georgia, that may as well be 40 below. As for blue, I don't do blue. Sorry. No "Marley and Me", or anything else that is "guaranteed to make me cry". As much as I respect "Old Yeller" as a fine piece of entertainment, and as much as I do believe that my son would benefit greatly from watching it, that probably will not happen. I have recently rented "Son of Flubber" from the library, which is still quite funny. And we have overdosed on the 1st and 2nd seasons of "Lost in Space", which my son absolutely loves. LOVES. I, however, am not adverse to the thought of beating Dr. Smith senseless with one of the arms from the robot, just to stop his whining. Anyway, should you want to watch ANY episodes of "Lost in Space", just let me know… I think I can help you out. Stay warm.
Lynda On Friday, January 16 at 6:24 pm
Liar, Liar is bannned in my house because of the language. I have a copy because I love Maura Tierney and she is freaking wonderful in it. Kids only watch the cleaned up version that comes on television though. As for dvd collections…The Cosby Show's first season was a $9.99 value at the Cracker Barrel on our way south for Christmas. Listening to the kiddos laughing their heads off as they watched one episode after another made my heart sing. Now THAT's good tv!
pam On Friday, January 16 at 6:27 pm
I think you need The Carol Burnett Show! I'm addicted to Intervention too, I hope for a happy ending everytime!
Melissa On Friday, January 16 at 6:27 pm
When I was talking to my mom, she recalled a time here in WI when she had to walk to school when it was -52 degrees without the windchill. Kinda reminds me of those stories of "walking to school uphill both ways" LOL
Tara On Friday, January 16 at 6:29 pm
We've worn shorts at tees all week here. Sorry everyone! It actually doesn't seem right for winter!
Try spreety.com for old tv shows – they have Gilligan and others. I love watching Gilmore Girls and Friends when I have time.
Wish I could send you all some sun!!!
Kim On Friday, January 16 at 6:32 pm
I like the photos. We are lucky to be having a chinook up here in Alberta! Yay! We are above freezing and should be for 3 more days!!! Sorry you are blue, I feel that way somedays too!
Marjie On Friday, January 16 at 6:33 pm
I don't even want to talk about the temperatures here this week. "They" are promising us it will "warm up to 16″ by Sunday. Where the hell is my global warming? I'm glad I don't have to leave the house.
Peggi Lee On Friday, January 16 at 6:34 pm
Dear Ree,
I feel your pain. Yesterday, the actual temperature here in northeastern South Dakota was -42 degrees. The windchill was -60. That's the coldest it's been here in 15 years.
To get rid of your winter induced slump, I highly recommend the DVD of Bill Cosby, "Himself". The first time I watched it was as a newlywed 25 years ago and thought for sure he was talking about my parents. Five years later he was talking about me! Twenty-five years later my children howl with laughter as they think he's referring to my husband and I!
Lindie On Friday, January 16 at 6:36 pm
Not my kind of shows or movies! I watch Monk which entertains and intrigues, watch Top Chef or Iron Chef, old movies where I of course know the endings.
Pam McL On Friday, January 16 at 6:37 pm
Ohio has been hit with the "below zero" temps…so I went to the library and got a Bing Crosby dvd and the 1st season of Get Smart on dvd. I plan to watch them tomorrow while my husband and boys are off on a winter hike with the Boy Scouts.
Hope you get outta the "Winter Bues" slump soon.
Jillian On Friday, January 16 at 6:37 pm
When I was in kindergarten and early elementary school my grandmother would record Mr. Rogers when it came on TV, since it came on at a time I was in school. Then when I got home, I'd head over to her place and watch it. I adored Mr. Rogers. Hope you're staying warm, we're having rather cold weather here in FL as well although nothing compared to you and some of the other commentators. It got up to about 48 here today. Go us!
Cindy On Friday, January 16 at 6:39 pm
You should watch a good 'ol Canadian show – Corner Gas. It's set in a rural Saskatchewan (small) town, and it's a hoot to watch. Guaranteed to crack you up
Shelle On Friday, January 16 at 6:41 pm
I'm sorry but that is why Napolean Dynamite and 4 Christmases have topped my list of the FINEST movies alive. I HAVE to laugh…each and everyday…
But sometimes…it's okay for me to watch a FEEL good movie…
Or a Drama on TV…Grey's Anatomy and Private Practice…where I cry and bawl and smile and laugh!
Then I have to watch a stand up comedy by Dane Cook or someone similar…
AnnMarie On Friday, January 16 at 6:41 pm
Hey Ree..
Have you seen the previews for the new Showtime series staring Toni Colette? It looks pretty good. Starts this weekend I think. Hope you have Showtime, if not GET IT!!!
Melissa On Friday, January 16 at 6:45 pm
Did you see that Toni Colette has a new sitcom coming out. It looks hilarious! Thought of you when I saw the preview!
Lizzie On Friday, January 16 at 6:46 pm
Hi Ree! You should start watching Reba. Her show comes on Lifetime. My family and I love it!
Gail On Friday, January 16 at 6:48 pm
Where do you even find the time to watch all this stuff? I swear, woman, you must never sleep! But such beautiful pictures. I live in Florida and it's cold here too (for us). I had to cover my tomatoes, eggplants and pineapples. I guess I shouldn't complain though. The birdbaths haven't frozen yet. And I do have a fireplace too, and I think I might have to throw a few pieces of oak on it tonight! Love you and your stories!
St. Fairsted Farm On Friday, January 16 at 6:49 pm
Okay, you brought it up with Dinah Shore so I have to admit I love Doris Day in "Please don't eat the daisies."
Yes before my time but I was blessed with having a dad who loved the old movies to share with me the greatness in oldness.
Texas Emily On Friday, January 16 at 6:49 pm
A great chick flick is Bonneville….Jessica Lange and Kathy Bates. Trust me!
Theresa in Alberta On Friday, January 16 at 6:50 pm
I tried to watch Intervention once. I could not, too real life. I work in a downtown city and I see the street people and am so sad for them. I bought the Waltons series on DVD, that is nice to watch and do some knitting. OHYAH, and read my blogs
michelle On Friday, January 16 at 6:52 pm
It was a nice -11 here today.
I DVR Intervention every week. Love that show. Makes me realize my life ain't so bad. As for a few good laughs, I watch an episode of Friends every night before I go to bed. Sometimes I change it up a little and do a MASH marathon. What a hoot!
megank On Friday, January 16 at 6:53 pm
You can watch Sesame Street on youtube… OR it comes on here in Bville at 9:00 am on OETA.. I only watch it when my two year old can. *wink* OK so I occasionally watch it with out her.
Carol On Friday, January 16 at 6:53 pm
I remember Hee Haw! It used to come on every Saturday night. It was good family entertainment.
Schnoobie On Friday, January 16 at 6:53 pm
I suggest Frasier reruns, Fried Green Tomatoes, Ferris Buellers Day off,Danny Deckchair, "Greater Tuna" (on dvd from Netflix 2 man 20 character stageplay) Step Brothers.. I feel ya though its 20 below these parts but… we have had the rare appearance of the big glowing orb in the sky the past 2 days ( so unusual to see the sun here in NW IN winter….the grey skies are chronic blehhhh) Chin up bunky… I've heard Sam-E vitamin supplement helps too…
JoAnn On Friday, January 16 at 6:54 pm
I assume that you know that a regular fireplace actually makes your house cooler because it draws the existing heated air up the chimney. It only feels warmer when you are right in front of it (this is because radient heat heats an object, not the air). We did a lot of research on this before we built our last house and ended up with a Vermont Casting woodstove for one fireplace and a gas fireplace for the other room.
By its design, a standard open fireplace is less than 10% efficient which means that most of the heat is going right up the chimney. Compare this to a wood burning insert which is typically around 70% efficient and you'll understand the difference.
Sandy On Friday, January 16 at 6:55 pm
What about Tressa on Intervention? Let's discuss. That is my favorite episode!
Sally McEntire On Friday, January 16 at 6:55 pm
I know you just warned me, but now I have to see what Alpha Dog is all about.
Lovely pictures.
krg On Friday, January 16 at 6:55 pm
never heard of intervention because I hardly watch tv.
thanks about alpha dog. never
sophie's choice. never. ever. ever.
I don't have to have a happy ever after, but, I don't need a never happy ever after. ever.
Jackie On Friday, January 16 at 6:56 pm
You forgot GREEN ACRES!
We just bought the DVD set – remember "Arnold", the pig? Who didn't get past second grade because holding the pencil was a challenge???
I don't want to watch anything DEPRESSING or SAD!!! No, no, no, no no……
Lene On Friday, January 16 at 6:57 pm
Those photos are breathtaking. Stunning. Wow.
Stephanie On Friday, January 16 at 6:58 pm
I love your pictures, they are stunning! I can relate to the blue-ness that he cold winter can bring…have you ever watched 7th Heaven or the the "Love Comes Softly" series from the Hallmark Channel? Those also bring a smile to my face (sometimes a stray tear too, but ultimately a smile)!! I hope you get over your blue period soon!
wookie On Friday, January 16 at 7:09 pm
You need to watch Life is Beautiful
It's so …beautiful…you'll cry, but you'll be happy at the same time.
Robbie On Friday, January 16 at 7:10 pm
For the last two weeks the thermostat at work has not been above 68. We're not exactly freezing, but it's a far cry from toasty warm. I marched into Sears and purchased three sets of Cuddle Duds. Now I'm warm and comfortable with my cozy underwear, turtlenecks and sweaters. I have told all the female faculty members about them. Every morning someone smiles and asks me, "Have you got on your Cuddle Duds?" I politely slide my pants leg up to reveal my prized possession. If you don't have some Ree, you need to get some for you and your girls. You'll be sooooooo glad you did!
Devon On Friday, January 16 at 7:11 pm
I'm worried about your movie choices! Time to lighten it up, why don't you put on Saving Private Ryan for a little more merriment!
Jenny D! in GA. On Friday, January 16 at 7:12 pm
Like everyone else has said… these pictures are really cool. Cold! It's cold in the south too. I've had to go break the ice out of our dogs bowl for 3 days now… and we never freeze for 3 days. We started today at 12 and got a whoppin' 33 this afternoon before quickly dipping back into the 20's. Nothing like where you are… but that's why we live in GA!
Go snuggle Charlie
Jenny D! in GA. On Friday, January 16 at 7:12 pm
as a numbers person… my post at 7:12 is my birthdate. I like numbers.
tbaat On Friday, January 16 at 7:13 pm
I'm SURE someone has already mentioned this to you, but I can't see something about Toni Collette and not think of you! She has a new show called "The United States of Tara" starting this Sunday on Showtime!!!
Angela On Friday, January 16 at 7:13 pm
Okay, I totally relate to being brought "low" by certain movies, themes, etc. I have an idea for you. Go to Hulu.com and watch about six episodes of "I dream of Jeannie" in a row. It'll cure your funk. Promise.
(And why do shows like that, from the time when it seemed nothing was more complicated than Jeannie and Tony's relationship, seem to put stuff in perspective? LOL!)
Laura Holden On Friday, January 16 at 7:13 pm
I am so glad I am not the only one in a slump! Not that I'm happy you're in a slump, mind you. I have been moody all day. I know I'm moody and I can't do a thing about it. I hate hormones!! Now I want to watch the movie just to drag myself down even more. That way, when I bounce back, it will be so much better! I'm sick and twisted like this at times.
Anneli On Friday, January 16 at 7:16 pm
I love movies, and know a shameful amount about them, even if I've never seen them. Alpha Dog, if memory serves me correct, has Justin Timberlake in it.
Rest assured, I would not watch Alpha Dog if I got paid for it.
jensamom On Friday, January 16 at 7:18 pm
I loved Dinah Shore…also Merv Griffin and Mike Douglas…Hope you warm up soon.
Tina On Friday, January 16 at 7:22 pm
Beautiful photos that make me feel the cold. No wait…that is actually cold I'm feeling! It was 13 below zero this morning here as well. Right now is 1 above zero and falling. Brrrr.
Hey you gave away your Nikon so what are you shooting with now? Did you get a new camera? Do tell!
michelle On Friday, January 16 at 7:22 pm
what beautiful pictures ree!!
Teresa in KY On Friday, January 16 at 7:23 pm
I've not seen Alpha Dlog. Will trust I probably shouldn't. As for Intervention I have been drawn to it as well – and I really don't know why. I usally have a sick feeling after watching. Now Hee Haw is what I always watched on Saturday nights with my family growing up……memories…. But looking at your blue photos certainly puts me at ease. They are breathtaking.
Val On Friday, January 16 at 7:24 pm
Are these pictures straight out of the camera, or did you 'blue' them up a bit? They're very striking! If that's the view from your yard I definitely living in the wrong state! ;o}
rocky in ND On Friday, January 16 at 7:24 pm
I'm with #44 in ND – boy has it been cold here. We had -37 yesterday morning! What a way to celebrate my b'day!! My favorite oldie show is the Walton's – I get my daily fix on the Hallmark Channel, at 8 a.m. after the kids are on the bus. Great Blue photos Ree!!
Vicki M. On Friday, January 16 at 7:27 pm
You need to watch Princess Bride. Because in that movie you can be only "mostly dead" and "true love" is the solution to almost anything. And any mother knows what true love is all about.
Rebecca On Friday, January 16 at 7:29 pm
Those photos are AWESOME!! I can only hope to be half as good as you some day!! As for cold, how's this? Last night we had to run to town for some milk, and the thermometer in our van (which is always VERY accurate) told us that it was -25 F! -12 in town, but out in the country, it was a bit colder for us!! And we are all the way down in southern Iowa!
Bev On Friday, January 16 at 7:30 pm
I choose not to watch movies that bring me down in any way. I've been told I don';t like to face reality. Well, it's my choice, and I want happiness love, light, encouragement, all good things, but absolutely happy endings!
Wendy On Friday, January 16 at 7:31 pm
That's funny. I actually COULD send you some Brady Bunch. As long as you have a VHS and you don't mind commercials from the 80's.
Kylie On Friday, January 16 at 7:34 pm
We just went to the zoo today at it was 78 degrees (crazy how different the weather is from one place to the next)!
With love from SUNNY Az…
Bridget On Friday, January 16 at 7:37 pm
My aunts and uncles were debating, long ago, whether Dinah Shore was any good as a singer.
One said "Dinah Shore can't sing!" My Grandma (bless her soul) replied, "Oh, yes she can. I just heard her on The Merv Griffin Show."
Sandie On Friday, January 16 at 7:37 pm
school's have been closed for last 2 days due to the cold here in WI. I go to work and dash from car to building as fast as I can in this old body. My dogs don't want stray far from the back door when I let them out to go potty. I feel sorry for them.
Rose On Friday, January 16 at 7:41 pm
I also love Gilligan's Island, it's on our "Retro" tv channel all the time. I would really like to watch episodes of Wonder Woman (the original tv show with Linda Carter) and also The Carol Burnett Show. I wish they would bring shows like that back to television, I am soooo sick of "reality" tv. I watch tv to escape reality, not face more of it!!! Also, it was +7C here today, which is really unusual for Northern Alberta, but I was loving it. I can't wait til spring!
Susan On Friday, January 16 at 7:45 pm
Well…in the San Franciso bay area, it's been in the 70's all week. It's been beautiful. But, we need the rain..hold the cold though, please.
And movies? The MOST DEPRESSING movie I saw recently, that you must NEVER WATCH, is "The Mother."
OMG..I've never seen such a depressing movie. What's worse is, I'm this womans age. It struck me down. Ugh.
The blue photo's are lovely. I can't decide if they convey the weather or your mood. Maybe both?
Jersey Lou On Friday, January 16 at 7:53 pm
Clearly, you need to spend some time with Alice and Sam the Butcher!
Alicia On Friday, January 16 at 7:56 pm
If I could chop through the goat's water to let them drink I'd do it! It's frozen to the bottom morning and night and I'm carrying them nice warm water for a treat twice a day Luckily this is a hippie farm and we don;t depend on it to support us.
Anita On Friday, January 16 at 7:56 pm
Beautiful photos Ree,kinda chilly here in S.W. Ga. also.
Stay warm friend.
Diane Cooper On Friday, January 16 at 7:56 pm
Gorgeous photos Ree! It s cold here too! Brrrr…
Sounds like Charlie has a steel trap for a bladder just like my dog… I can hardly blame them though!
"Benny and Joon" is a movie that would definitely get you out of a funk!!! I highly recommend it! Johnny Depp's best performance I think!
Sending warm hugs (well as warm as I can get them here in Toronto Canada!)
Cheri H. On Friday, January 16 at 7:57 pm
As a fellow girlfriend, I say "update your movie watching"!
No need to be depressed when the weather already is.
I live in S.California, so I'm never depressed, ha! Okay,
may I suggest the Love Comes Softly series, there are five dvd's,(watch in order). They are right up your "prairie alley" haha. Really, I think you would like them. I bought them all at Amazon.com. They are based on the books by Christian author, Janette Oke. God bless you and your adorable family. C.Bug of O.C.
Melanie On Friday, January 16 at 8:00 pm
The way you feel about Alpha Dog very much describes how I felt after watching Requiem for a Dream. If you haven't seen, for God's sake, DON'T.
It will ruin your mood for days.
Bette On Friday, January 16 at 8:03 pm
I love the "blue" (literally and figuratively) photos. I grew up in the Midwest and know cold (boy, do I ever) but now live in the Southwest. It was 80 today. There's something just plain old wrong with having to use the A/C on a January day.
Life is depressing enough so I prefer to watch brainless comedies. Bring on the Gilligan's Island!
Renee On Friday, January 16 at 8:03 pm
Beautiful pictures!
I haven't seen any of those movies and really don't want to now. I try to stay away from those things – winter can be gloomy enough!
Karen Matheny On Friday, January 16 at 8:05 pm
Breathtaking photo's! It was 4 degrees here in Ohio today, I really like Sophie's Choice, but when I'm cooped up in the winter, I can't watch movies that make me cry, I get cabin fever depression. I'm watching, " You've Got Mail" Happy thoughts, and stay warm!
Chris in San Diego On Friday, January 16 at 8:07 pm
Would you hate me if I told you we had the record high for the nation yesterday with 90 degrees at the San Diego Wild Animal Park in Escondido??? Today it got up to 84 and my husband actually turned on the AC too cool off the upstairs??? I am sorry if anyone is offended but then I grew up in St. Louis so I paid my dues. :o)
Kathy J On Friday, January 16 at 8:07 pm
Terms of Endearment was filmed on the campus where I went to college. We used to call it Tears of Endurement for the long detours to class we had to take during filming.
When they go on the highway and they show the Leaving Texas sign – that was my neighborhood.
Apparently Debra Winger was having a fling with the then single governor of my state. That this fact made news at the time just shows you how desperate we are for news of any kind. Lets not even talk about the time Harrison Ford was spotted in a local topless bar. He was waiting for his plane to be repaired or something!
Oh yes – I was a candystriper in the hospital poor Debra Winger died in in that movie – SNIFF
jodi On Friday, January 16 at 8:07 pm
So I'm not the first to ask this, I checked (#115 :)) But that whole HORMONES thing makes me think you're pregnant and trying not to tell us … maybe?
Bboss On Friday, January 16 at 8:08 pm
Beautiful pictures. I can't believe you stood outside to take them! I"ve never seen "Terms of Endearment" or "Sophie's Choice".. I don't think I could handle either one.
Paula On Friday, January 16 at 8:10 pm
TVLand.com – Gunsmoke, Beverly Hillbillies, and more!
We hit 7 degrees here and talk about cold. You need a pretty good set of biceps to crack the pond ice! I do like the blue pictures – just seems calming.
Lori On Friday, January 16 at 8:10 pm
Wouldn't you like The Andy Griffith Show to be on that dvd list of uplifters? If I had a stack of those, I'd send them along, too. The black and white ones.
Trish On Friday, January 16 at 8:13 pm
Add my voice to the chorus who is asking "are you pregnant?"
Sarah Erickson On Friday, January 16 at 8:13 pm
Its interesting that you are so cold living in Oklahoma…..I am here in Fargo, ND where for the past week schools have been either cancelled or running 2 hours late due to a wind chill warning. A wind chill warning is only in effect if the temperature with the wind chill gets to 40 below zero or colder. I AM FREEZING! I hope you stay warm in your above zero temperatures as i am jealous!
Joyce Nell Matta On Friday, January 16 at 8:19 pm
Ree, I think you would like "Imitation of Life" and "Love Me Or Leave Me", two old movies that I really love. Don't worry they are in color!!!!!! Great movies!!!!!
Tammy On Friday, January 16 at 8:20 pm
I guess it would be kinda mean of me to tell you that we are having a bit of a heat spell here in Cali….like in the 70's…like I still turn my air conditioning in my car. Not to be mean….but just in case you are curious.
I don't have any of those shows to send you, but I can sing the themes to Brandy Bunch and Gilligan Island pretty darn good if I may say so myself. But not good enough for YouTube.
Joyce Nell Matta On Friday, January 16 at 8:21 pm
By the way it was a nice 67 degrees here today. We could use some cold weather her in Miami, Fl, it's been in the 80's all winter. Kinda sucks……..I'm a native, never seen snow, except 1977 when it snowed in Miami!!!!!
Glenda Rodriguez On Friday, January 16 at 8:22 pm
I'm not much on watching movies but I love intervention!
If I have one tevo-ed, I cant sleep til I watch it!
It would be wonderful if we could go through a pregnancy with you. I vote ,if your not pregnant, you get that a way!!Much love, and maternal advice,
♥ Glenda
Kathy On Friday, January 16 at 8:22 pm
Maybe you should school your punk instead of being such a narcissist.
Janet On Friday, January 16 at 8:24 pm
Ugh, thanks for the warning about the movie..I'll definitely miss that one. I suggest you watch "Everybody Loves Raymond" That show always makes me laugh. OR, put on some old Ronnie Milsap music. I bet you'll be shakin' your hiney while you cook dinner before you know it! Hang in there!
Juli in Saint Paul, MN On Friday, January 16 at 8:24 pm
It has been below zero here since Monday, yes I said MONDAY. Today I got up and the thermometer read -22. My dog, Ted, does not like the cold and can hold it. Well, I thought he could hold it. I have since found him out. He has a corner in my son's bedroom that is his "fence post" much to my dissatisfaction . . . . he's now forced out the door every few hours.
Thankfully, I don't have to go and chop ice on Puddin's trough . . . Just the occasional shovel of snow that's falling.
I am officially done with winter here though.
Juli in Saint Paul, MN On Friday, January 16 at 8:24 pm
Oh and I curl up to "I Dream of Jeannie."
Love that show . . .Cocoa Beach is the best!
Heidi On Friday, January 16 at 8:26 pm
Beautiful! Now we need a how-to on these babies in your Photography section.
I've never seen any of those movies, but we have "The Cosby Show", "Little House on the Prairie" and "The Waltons" that are sure to pick you up anytime!
Beth (in NC) On Friday, January 16 at 8:27 pm
I watch Intervention so that I can cry…. if I'm having troubles, feeling low, and can't cry, that'll do er every time!
Penny Wolf On Friday, January 16 at 8:29 pm
Nice pics as usual. Why does everyone think pregnant
when horomones are mentioned? It could mean PMS, or
pre-menopause, or pregnant. NOT JUST PREGNANT.
mysuestories On Friday, January 16 at 8:33 pm
You can't possibly have time to live such a wonderful life, tell us all about it with such flair, AND read all these posts…but on the outside chance you stumble on this….Love your writing, you keep posting, I'll keep reading!
mysuestories On Friday, January 16 at 8:33 pm
You can't possibly have time to live such a wonderful life, tell us all about it with such flair, AND read all these posts…but on the outside chance you stumble on this….Love your writing, you keep posting, I'll keep reading!
Lindsay On Friday, January 16 at 8:34 pm
What you need is an Anne of Green Gables marathon. A little Gilbert goes a long way.
Lynn Dirk On Friday, January 16 at 8:34 pm
How cold is it? Wedensday we had a whopping minus 45. I keep telling my husband "I'm from the OC dag gummit!" He just makes that man noise "hmmm" and goes right on about his day.
Sweet photos and great movie choices. But hey don't forget about Green Acres seeing as how you and MM are a whole lot like Lisa and Olivar except, well, you can cook. And hey, Charle could be Arnold Ziffle…..
Stay Warm-Cuddle Up!
Charlie Bennett (female) On Friday, January 16 at 8:36 pm
i hear ya on the cold!!!
BTW – Ree you know Alpha Dog is based on a true story! makes it even more sad to me….
Carla On Friday, January 16 at 8:39 pm
Love the photos, please tell us how you got those beautiful colors. Please don't tell me they're SOOC shots, if so I'm so jelous.
sue Thompson On Friday, January 16 at 8:40 pm
you might want to try Gilmore Girls, Reba and Christy. All great stories that are mostly uplifting and are series so you can watch a good long time AND they come in the mail if you can order through Blockbuster. I only watch shows and movies that leave me feeling good since there is just too much in the world that is hard to watch. Have fun watching something FUN!!!
Harper On Friday, January 16 at 8:40 pm
I'm an "Intervention" addict too!
Julia On Friday, January 16 at 8:41 pm
Beautiful blue pictures. I hope you warm up soon.
susan On Friday, January 16 at 8:45 pm
last winter we rented from netflix;
season by season of ; the waltons and little house on the prairie. boy, after watching those good ol' shows you realize what "crap" there is out there today. these shows are truly about what's important in life!!
another feel good series "anne of green gables"
Elizabeth B On Friday, January 16 at 8:46 pm
I love Mr. Roger's. He's wonderful – do they have his show on DVD?


text:
Now Playing
Connect with Us
KRWG.ORG-The Region's Home Page
Director of Content
News Director
Multimedia Reporter
Fronteras Reporter, KRWG-FM and Anchor, KRWG-TV's Fronteras-A Changing America
Operations Manager, KRWG-FM And Anchor, KRWG-TV's Fronteras-A Changing America
Host, KRWG-FM's Fiesta! and PUENTES
KRWG Jazz Host
Host, Friday Night Blues; Saturday Night Jazz
Host, KRWG-FM's Intermezzo
Host, KRWG-FM's Intermezzo
5:56 pm
Wed October 2, 2013
Boehner, Obama Meet But Make No Progress On Deal To End Shutdown
By Mara Liasson
Day two of the government shutdown is nearing its finish, with no end in sight. And that's in spite of talks at the White House late today. President Obama met with House Speaker John Boehner for over an hour Wednesday evening. The meeting failed to produce a deal that would end the federal government shutdown.

subset: commoncrawl


text:
Talking Spring Racing Fashion On Radio National
On 8 November, 2013, I spoke to Cassie McCullagh and Jason DiRosso of ABC Radio National's program The List about the class dimensions and carnivalesque role of spring racing fashion.
ACMI Hollywood Costume Public Events
As film, clothes and archives are some of my key research interests, I gave numerous public talks about screen costume during the Hollywood Costume exhibition, which ran at the Australian Centre for the Moving Image from 24 April to 18 August, 2013.
Out of Shape Radio Interviews
In June, 2013, I promoted my book, Out of Shape, with radio interviews on local and national stations. Listen to recordings of my interviews.
Behind Every Brilliant Writer
When British author JG Ballard died in April 2009, I was disappointed by the near-absence of his long-term partner, journalist Claire Walsh, from most obituaries. In this post at feminist blog The Dawn Chorus on 20 April, 2009, I examine the figure of the female 'muse'.
Free Your Signifier And The Rest Will Follow
This blog post focuses on the wearing of Palestinian headdresses, or keffiyeh, as fashionable neck scarves. It appeared on my fashion research blog, Footpath Zeitgeist, on Thursday 4 May, 2006, and has since been much-linked and cited.
Lygon Court Retail Directory
In January 2009, Right Angle Studio commissioned me to write the copy for a poster (with art by Rik Lee) promoting Lygon Court shopping centre to students at the nearby University of Melbourne.
Super Tasty Rooster
It's possibly Melbourne's best-named charcoal chicken shop, and I reviewed it for ThreeThousand on 16 October, 2008. When I went back, my review was taped to the bain-marie.
Gosteleradio: Great Deeds Against The Dead
In February 2010, I wrote a track-by-track guide to Great Deeds Against The Dead, the debut album of Melbourne band Gosteleradio, to be included with pre-release press copies of the album.
Big vs Lil: A Hip-Hop Journey
This playful mini-essay sizes up hip-hop culture, comparing rappers who call themselves 'Big' to those who are 'Lil'. It appeared in issue seven of Is Not Magazine, "Bigger Is/Not Better", in March 2007.
Eats, Shoots And Blogs
'Street style' has become one of the most popular fashion blogging subgenres. For this feature I interviewed two 'street' photographers. It originally appeared in The Sunday Age's 'M' magazine on Sunday 11 January, 2010.


text:
Variables Vocab
Parts of a graph
We learned about the TYPES of graphs, now we are learning about the parts of a graph. Use the flashcards to help you learn the difference between the x-axis & y-axis, manipulated & responding variable along with their location on a line graph. Listen
Science Tools
This week we will be learning about tools we will be using in the lab and how to use them. Make sure you can match each image and definition along with the correct units for your test on Friday! Listen
Significant Digits Rules
Here are some flashcards to help you review the 5 rules for significant digits….study up! Listen
Microscope Function Cards
Now that you know the parts, here are some cards to help you identify what each part does. Make sure you can match up the part with its function. Good Luck! Listen
Microscope Parts Cards
Here are some flashcards with visuals to help you identify the parts of the microscope. Enjoy! Listen
Scientific Method Flashcards
Here is a new set of flashcards to help you prepare for our upcoming quiz. Quizlet offers many ways to review and will read the cards/definitions to you! Be sure to study and try out scatter for a fun way to review! Enjoy! Listen
Lab Tools Flashcards
Below are our newest flashcards to help you review the tools we will be using in science this year. Make sure you know them for our quiz in Friday! Listen
Math in Focus Chapter 1-The Real Number System Vocab
Below are flashcards I created using Quizlet. These are the new vocabulary terms for Chapter 1 in our new textbook Math In Focus (Course 2). I love quizlet because there are many ways to learn; you can listen to the words and even play games to help you recall the terms and their definition. Make…


text:
About LIC
LIC is one of the oldest farming co-operatives in New Zealand. It's our vision to improve the prosperity and productivity of our farmers.
We are proud of our history, dating back to 1909, having pioneered some of the biggest innovations that provide today's farmers with their competitive edge on the world stage, including the systematic testing of milk quality, Long Last Liquid (fresh) semen, DNA technology to genomically identify and select elite sires, and more recently, a short gestation bull team bred to deliver offspring an average 10 days early.
Our commitment to farmer prosperity and productivity continues today, with genetics and information to create superior livestock; information to improve decision making to enable superior livestock; hardware and systems to improve productivity and decision making; and LIC International - adding value for shareholders, focussing on key markets.
Strong investment into research and development also continues, to deliver on future farmer needs.
We supply three-quarters of the country's bull semen, as well as information and automation systems, herd testing and diagnostics to drive efficiency and productivity gains on-farm.
Our subsidiary business, Dairy Automation Limited (DAL), also provide milk testing sensors that measure fat, protein, somatic cell counts and volume, and present real-time data while a cow is being milked.
With offices locally and internationally, we have a large team of staff with a wide range of knowledge and expertise.
More than 800 employees are based in offices around New Zealand, increasing to around 2000 for the peak dairy mating season.
LIC's head office is in Newstead, Hamilton, with offices in the United Kingdom, Ireland, Australia and Brasil, plus distributors in China, Japan, South Africa and South America.


text:
Scooped: Spicy Pineapple and Tequila Sorbet
Growing up, my only exposure to pineapple was the sour, fibrous, cardboardy stuff you find at continental breakfasts in crummy hotels everywhere. I blame it on being a child of the North. Never did I enjoy the classics that the rest of country was so rightly making—pineapple upside down cake, pineapple and marshmallow fruit salad, or pineapple margaritas. More


text:
transfer Money to South Africa
Whether you are buying a property, settling a business transaction, or sending currency to or from South Africa for any other reason, TorFX can save you money.
Our exchange rates often beat the banks by over 3%, saving customers thousands of pounds on large money transfers.
Money Transfer Information:
When you transfer money to South Africa you will need the following information:
- Beneficiary name and address
- Bank name and address
- Account Number
- BIC (Bank Identification Code), also known as SWIFT code
Choosing a Currency Broker to Transfer Your Money:
Firstly you will want to get the best exchange rate for your currency, and also be sure that you are dealing with a company you can trust.
All rates quoted by TorFX are based on the interbank foreign currency market rate at the time of the transaction, which means that you benefit from our direct market access.
TorFX is a Fasttrack 100 company, regulated by HM Revenue & Customs as a money transmitter, and is a member of the Association of International Property Professionals.
Use TorFX for Your Money Transfers:
1) Open an account with TorFX. Registration is fast, simple and completely free, with no obligation to trade.
2) Speak to your dedicated currency account manager at TorFX to discuss your requirements and explore your options.
3) Once you have agreed to buy or sell currency, send us payment, and provide us with your transfer information. We will do the rest!
TorFX does not charge for international money transfers (another way you save money using our service). Some foreign banks may make a charge for receiving your currency, and we always advise that you contact your receiving bank to check whether you will be charged.


text:
Provided is a method of stimulating cartilage formation at a tissue site in a mammal. Also provided is a biocompatible scaffold. Additionally, a system for stimulating cartilage formation at a tissue site is provided. Further provided is the use of a manifold, a chondrocyte, and a reduced-pressure source to stimulate cartilage formation at a tissue site of a mammal.
1. A method of stimulating cartilage formation at a tissue site in a mammal, the method comprising: applying a chondrocyte to the tissue site; positioning a manifold in fluid communication with the tissue site; and applying reduced air pressure to the tissue site by applying reduced air pressure to the manifold, wherein said applying reduced air pressure to the tissue site causes new cartilage formation at the tissue site.
2. The method of
3. The method of
4. The method of
5. The method of
6. The method of
7. The method of
8. The method of
9. The method of
10. The method of
11. The method of
12. The method of
13. The method of
14. The method of
15. The method of
16. The method of
This application claims the benefit of U.S. Provisional Application No. 61/076,028, filed Jun. 26, 2008, incorporated by reference.
1. Field of the Invention
The present invention relates generally to tissue treatment systems and in particular to methods for stimulating cartilage formation.
2. Description of Related Art
Clinical studies and practice have shown that providing a reduced pressure in proximity to a tissue site augments and accelerates the growth of new tissue at the tissue site. The applications of this phenomenon are numerous, but application of reduced pressure has been particularly successful in treating wounds. This treatment (frequently referred to in the medical community as "negative pressure wound therapy," "reduced pressure therapy," or "vacuum therapy") provides a number of benefits, including faster healing and increased formulation of granulation tissue. Typically, reduced pressure is applied to tissue through a porous pad or other manifolding device. Unless otherwise indicated, as used herein, "or" does not require mutual exclusivity. The porous pad, often an open-cell foam, contains cells or pores that are capable of distributing reduced pressure to the tissue and channeling fluids that are drawn from the tissue. The porous pad is generally sized to fit the existing wound, placed in contact with the wound, and then periodically replaced with smaller pieces of foam as the wound begins to heal and becomes smaller. The porous pad often is incorporated into a dressing having other components that facilitate treatment. While reduced pressure therapy has been used to treat soft tissue injuries, it has not been used to promote, for example, cartilage regeneration.
Damage to cartilage through age, injury, wear and metabolic disorders, such as osteoarthritis, affect millions of people throughout the world. Indeed, it is currently believed that 85% of all Americans will develop degenerative joint disease as a result of normal activities that damage cartilage. The gradual degeneration and destruction of articular cartilage may be due to trauma, structural deformation of the joints and being overweight. The process thins the cartilage, in part through programmed cell death, or apoptosis. The clinical manifestations of cartilage damage or wear are often painful and debilitating, including swelling of the joint, crepitation, and decrease in functional mobility. As the condition worsens, pain may even limit minimum physical efforts and persist at rest making it difficult to sleep. If the condition persists without correction and/or therapy, the joint can be totally destroyed, leading the patient to major replacement surgery with a total prosthesis, or to disability. The complications of cartilage injury are multifold. For example, injured cartilage tends to cause additional damage to articulations and the articular surfaces. Damage to articular surfaces is linked to bone spur development, which further limits joint movement.
Moreover, cartilage is the main structural support of various parts of the body, such as ears and the nose. As such, a lack of cartilage from injury may also result in a cosmetic defect. Thus, in sum, damaged and degraded cartilage results in a reduced quality of life.
The body, however, cannot completely repair the cartilage. Cartilage is primarily composed of collagen fibers, proteoglycans and elastin fibers that form an extracellular matrix. The matrix is formed by specialized cells called chondrocytes. Chondrocytes are one of the few cell types that can survive with a minimal blood supply. However, when cartilage is damaged, the lack of an adequate blood supply to the chondrocytes results in an inability to regenerate new chondrocytes, a process that requires an increased amount of nutrients and access through the blood stream to other cells and proteins. Full thickness articular cartilage damage or osteochondral lesions may allow for normal inflammatory response, but then result in repair with functionally inferior fibrocartilage formation.
Current techniques to inhibit or delay degeneration of joint cartilage include use of anti-inflammatory agents, chondrogenic stimulating factors, antirheumatics, systemics, viscoprotection and injection of depot steroids. Other methods include implantation of chondrocytes or synthetic matrices. One method of treatment for cartilage damage is surgical intervention, with reattachment and reconstruction of the damaged tissue. None of the above methods are totally satisfactory, and those methods rarely restore full function or return the tissue to its native normal state. In addition, none of those methods are proven to regenerate cartilage in situ and in vivo.
Further, there is no proven way to promote healing of dense connective tissue structures such as ligaments and tendons. Ligament and tendon injuries are commonplace and difficult to heal. Indeed, it is not uncommon to repair complete ruptures or tears of a ligament or tendon by immediate surgery to remove the damaged tissue and replace it with a graft. Post surgery, a graft recipient has to experience the long task of rehabilitation and healing. It is often difficult to repair ligaments and tendons by current methods. Thus, when repair is an option, the joints and muscles attached to the ligament or tendon are often immobilized to enable the tissue to heal.
As such, there is currently an acute need for a safe, simple, rapid, inexpensive and efficient system and method for regenerating connective tissues in areas where the connective tissue is missing, damaged, or worn.
The problems presented by existing cartilage repair treatment regimens are solved by the systems and methods that utilize a biological material to stimulate the growth of cartilage as described by the illustrative embodiments herein.
In one embodiment, a method of stimulating cartilage formation at a tissue site in a mammal is provided that includes applying a chondrocyte or chondrocyte precursor to the tissues site and applying reduced pressure to the tissue site for a time sufficient to induce the growth of new cartilage at the tissue site.
In another embodiment, a biocompatible scaffold is provided that includes a chondrocyte or a chondrocyte precursor, wherein the scaffold is sufficiently porous to transmit reduced pressure therethrough.
In an additional embodiment, a system for stimulating cartilage formation at a tissue site is provided that includes a chondrocyte or chondrocyte precursor, a reduced pressure source, and a manifold capable of transmitting reduced pressure from the tissue site to the reduced pressure source.
In a further embodiment, the use of a manifold, a chondrocyte and a reduced pressure source is provided for stimulating cartilage formation at a tissue site of a mammal.
Other objects, features, and advantages of the illustrative embodiments will become apparent with reference to the drawings and detailed description that follow.
In the following detailed description of the illustrative embodiments, reference is made to the accompanying drawings that form a part hereof. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention, and it is understood that other embodiments may be utilized and that logical structural, mechanical, electrical, and chemical changes may be made without departing from the spirit or scope of the invention. To avoid detail not necessary to enable those skilled in the art to practice the embodiments described herein, the description may omit certain information known to those skilled in the art. The following detailed description is, therefore, not to be taken in a limiting sense, and the scope of the illustrative embodiments are defined only by the appended claims.
The term "reduced pressure" as used herein generally refers to a pressure less than the ambient pressure at a tissue site that is being subjected to treatment. In most cases, this reduced pressure will be less than the atmospheric pressure at which the patient is located. Alternatively, the reduced pressure may be less than a hydrostatic pressure associated with tissue at the tissue site. Although the terms "vacuum" and "negative pressure" may be used to describe the pressure applied to the tissue site, the actual pressure reduction applied to the tissue site may be significantly less than the pressure reduction normally associated with a complete vacuum. Reduced pressure may initially generate fluid flow in the area of the tissue site. As the hydrostatic pressure around the tissue site approaches the desired reduced pressure, the flow may subside, and the reduced pressure is then maintained. Unless otherwise indicated, values of pressure stated herein are gauge pressures. Similarly, references to increases in reduced pressure typically refer to a decrease in absolute pressure, while decreases in reduced pressure typically refer to an increase in absolute pressure.
The term "tissue site" as used herein refers to the location of a wound or defect on or within any tissue, including but not limited to, bone tissue, adipose tissue, muscle tissue, neural tissue, dermal tissue, vascular tissue, connective tissue, cartilage, tendons, or ligaments. The term "tissue site" may further refer to areas of any tissue that are not necessarily wounded or defective, but are instead areas in which it is desired to add or promote the growth of additional tissue. For example, reduced pressure tissue treatment may be used in certain tissue areas to grow additional tissue that may be harvested and transplanted to another tissue location.
Referring to
The system 100 comprises a reduced pressure dressing 110, which includes a manifold 111 adapted to distribute the reduced pressure to the tissue site 102 and a scaffold 112 adapted for placement adjacent the wound 106, and a drape 114 at least partially covering the reduced pressure dressing 110 to provide a seal covering the wound 106 at the tissue site 102. A chondrocyte or chondrocyte precursor can be placed directly on the tissue site 102 or be contained within a scaffold 112 that is applied to the tissue site 102. The system 100 further comprises a canister 115 with a filter (not shown) and a reduced pressure source 116, wherein the canister 115 is in fluid communication with the reduced pressure dressing 110 via a conduit 118 and is also in fluid communication with the reduced pressure source 116 via a conduit 119. The reduced pressure source 116 is adapted to supply reduced pressure to the manifold 111 and the scaffold 112 which distribute the reduced pressure to the tissue site 102 when in operation. The conduit 118 may fluidly communicate with the reduced pressure dressing 110 through a tubing adapter 120 to provide the reduced pressure through the drape 114 to the manifold 111.
In yet another embodiment, the reduced pressure dressing 110 may be constructed from multiple layers or materials in addition to or in lieu of the manifold 111, the scaffold 112, and the drape 114. Some of these layers may be bioabsorbable while others are not. For instance, the manifold 111 may include a bioabsorbable material adjacent to a bio-inert material or a bioabsorbable material that degrades more slowly (as the terms are defined below), such that the reduced pressure dressing 110 may be removed and replaced without removal of any absorbable scaffold 112, that supports tissue growth, from the wound 106.
The canister 115 may be a fluid reservoir, or collection member, to filter and hold exudates and other fluids removed from the tissue site 102. The canister 115 may include other devices (not shown) including the following non-limiting examples: a pressure-feedback device, a volume detection system, a blood detection system, an infection detection system, a flow monitoring system, and a temperature monitoring system. Some of these devices may be formed integral with the reduced-pressure source 116. For example, a reduced-pressure port on the reduced-pressure source 116 may include a filter member that includes one or more filters, e.g., an odor filter.
The reduced-pressure source 116 may be any device for supplying a reduced pressure, such as a vacuum pump, wall suction, or other source. While the amount and nature of reduced pressure applied to a tissue site will typically vary according to the application, the reduced pressure will typically be between −5 mm Hg and −500 mm Hg and more typically between −100 mm Hg and −300 mm Hg. The particular protocol used in reduced pressure treatment depends upon the location of the tissue site 102, the reduced pressure dressing 110, or pharmacological agents being utilized. Additionally, reduced pressure may be a substantially continuous or cyclical application such that it oscillates the pressure over time. The reduced pressure source 116 may include sensors, processing units, alarm indicators, memory, databases, software, display units, and user interfaces that further facilitate the application of reduced pressure treatment to the tissue site 102. In one example, a sensor or switch (not shown) may be disposed at or near the reduced pressure source 116 to determine a source pressure generated by the reduced pressure source 116. The sensor may communicate with a processing unit that monitors and controls the reduced pressure but is delivered by the reduced pressure source 116.
The cartilage may be any type of cartilage. For example, hyaline cartilage is the most common type of cartilage in the body and characteristically contains collagen type II fibers in its extracellular matrix. Hyaline cartilage is found in articular joints, costal cartilage (ribs), nose, larynx, and growth plate. Another type of cartilage is elastic cartilage found in ear, trachea and epiglottis. The third type of cartilaginous tissue, fibrocartilage, is present in the pubic symphysis, intervertebral disc, parts of the articular joints, menisci and in sites connecting tendons or ligaments to bones. There also exist various combinations or intermediates of these types of cartilage, such as the epiphyseal cartilage in the growth or cartilage plate.
The manifold 111 of the reduced pressure dressing 110 is adapted to contact the scaffold 112 or portions of the tissue site 102. The manifold 111 may be partially or fully in contact with the tissue site 102 being treated by the reduced pressure dressing 110. When the tissue site 102 is a wound, the manifold 111 may partially or fully fill the wound. The manifold 111 may be any size, shape, or thickness depending on a variety of factors, such as a type of treatment being implemented or the nature and size of the tissue site 102. For example, the size and shape of the manifold 111 may be customized by a user to cover a particular portion of the scaffold 112 and/or the tissue site 102. The manifold 111 may have, for example, a square shape, or may be shaped as a circle, polygon, an irregular shape, or any other shape. In one illustrative embodiment, the manifold 111 is a foam material that distributes reduced pressure to the scaffold 112 and the tissue site 102 when the manifold 111 is in contact with, or near, the scaffold 112. Foam material may be either hydrophobic or hydrophilic. In one non-limiting example, the manifold 111 is an open-cell, articulated polyurethane foam such as GranuFoam® dressing available from Kinetic Concepts, Inc. of San Antonio, Tex.
In some embodiments, the manifold 111 is made from a hydrophilic material, where the manifold 111 functions to wick fluid away from the tissue site 102, while continuing to provide reduced pressure to the scaffold 112 and the tissue site 102 as a manifold. Without being bound by any particular mechanism, the wicking properties of the manifold 111 can draw fluid away from the scaffold 112 and the tissue site 102 by capillary flow or other wicking mechanisms. An example of hydrophilic foam is a polyvinyl alcohol, open-cell foam such as V.A.C. WhiteFoam® dressing available from Kinetic Concepts, Inc. of San Antonio, Tex. Other hydrophilic foams may include those made from polyether. Additional foams that may exhibit hydrophilic characteristics include hydrophobic foams that have been treated or were coated to provide hydrophilicity.
In another embodiment, the manifold 111 is constructed from a bioabsorbable material, natural or synthetic, that does not have to be removed from the tissue site 102 following use of the reduced pressure dressing 110. Bioabsorbable material is material that is capable of being absorbed in the body or removed from the body by excretion or metabolic functions; prior to absorption, the bioabsorbable material may be chemically, enzymatically, or otherwise degraded in vivo into simpler chemical species. Suitable bioresorbable materials may include, without limitation, a polymeric blend of polylactic acid (PLA) and polyglycolic acid (PGA). The polymeric blend may also include without limitation polycarbonates, polyfumarates, and caprolactones. The manifold 111 may further serve as a scaffold for new cell growth, or may be used in conjunction with the scaffold 112 to promote cell-growth.
The manifold 111 may further promote granulation at the tissue site 102 as reduced pressure is applied through the reduced pressure dressing 110. For example, any or all of the surfaces of the manifold 111 may have an uneven, course, or jaded profile that causes microstrains and stresses at the scaffold 112 and the tissue site 102 when reduced pressure is applied through the manifold 111. These microstrains and stresses have been shown to increase new tissue growth.
The scaffold 112 may be placed adjacent to, in contact with, or substantially over the tissue site 102 to promote the growth of the cartilage in the wound 106. As indicated above, the scaffold 112 may also function as a manifold when transferring reduced pressure to the tissue site 102. The scaffold 112 is a three-dimensional porous structure that provides a template for cell growth of the cartilage 108 within the wound 106. Nonlimiting examples of scaffold materials include calcium phosphate, collagen, PLA/PGA, hydroxyapatite, carbonates, and processed allograft materials. The scaffold 112 may also assist in delivering fluids to, or removing fluids from, the tissue site 102. The scaffold 112 may further comprise a distribution surface 122 that is positioned adjacent to the wound 106 to facilitate fluid flow, chondrocyte migration, and the like for moving a fluid and other material to or from the tissue site 102 to the pores in the scaffold 112. In some embodiments, the scaffold 112 is flexible to conform to the shape or contour of the wound 106 at the tissue site 102. The design of the scaffold 112 may also serve to prevent cartilage overgrowth. The shape and flexibility of the scaffold 112 may be selected without undue experimentation depending on the type of cartilage being treated in the location of the cartilage in the body treated.
A chondrocyte or chondrocyte precursor may be grafted, or otherwise applied, to the tissue site 102 or the scaffold 112 to facilitate the growth of the cartilage 108. An example of a chondrocyte precursor is a mesenchymal stem cell. The source of the chondrocyte or chondrocyte precursor may be an osteochondral graft, autologous to the patient, or comprising allograft, xenograft, or artificially prepared tissue. In one embodiment, the tissue source may be chondrocytic cell cultures, such as chondrocyte or stem cell cultures which have been prepared through ex vivo cell culture methods, with or without additional growth factors. For examples of cell culture methods, see, e.g., U.S. Pat. Nos. 5,226,914; 5,811,094; 5,053,050; 5,486,359; 5,786,217 and 5,723,331. The tissue may also be harvested by traditional non-cell culture based means, using techniques such as mosaicplasty, in which cartilage is harvested using commercially available instruments such as Acufex7, COR System, or Arthrex7 Osteochondral Autograft Transfer System. Further, the tissue harvested may be applied directly to the scaffold 112, or may be cultured beforehand.
The cells, chondrocyte, or chondrocyte precursor may be transfected, either transiently or stably, to further comprise a recombinant nucleic acid. Non-limiting examples of such nucleic acids include those that encode a protein, such as a cytokine, an enzyme, or a regulatory protein; a regulatory nucleic acid such as a promoter that causes a native protein to be overexpressed or silenced (e.g., to inhibit cancer initiation or growth); an miRNA or another RNAi molecule; an antisense molecule; a marker to assist in monitoring tissue formation; etc. The skilled artisan can determine and prepare, without undue experimentation, a chondrocyte or chondrocyte precursor comprising an appropriate recombinant nucleic acid for any particular application.
Other cells may also be seeded onto the scaffold 112 and/or placed on or into the tissue site 102 to stimulate the growth of cartilage. Non-limiting examples include fibroblasts, immune cells, stem cells that are not a chondrocyte precursor, etc. In some embodiments, attachment of the cells to the scaffold 112 may be enhanced by coating the scaffold 112 with compounds such as basement membrane components, agar, agarose, gelatin, gum arabic, collagen types I, II, III, IV, and V, fibronectin, laminin, glycosaminoglycans, polyvinyl alcohol, mixtures thereof, and other hydrophilic and peptide attachment materials known to those skilled in the art of cell culture. In another embodiment, the cells are seeded onto the scaffold 112, and the scaffold 112 is incubated before the scaffold 112 is applied to the tissue site 102.
A cytokine may be applied to the tissue site 102 or in the scaffold 112 as indicated above. As used herein, a cytokine is a protein that affects cellular growth, proliferation or differentiation, including growth factors and hormones. In some embodiments, the cytokine is one that can encourage cartilage growth. Nonlimiting examples include bone morphogenic protein (BMP)-2, BMP-6, BMP-7, transforming growth factor-β (TGF-β), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), or cartilage-derived retinoic acid sensitive protein (CD-RAP). The cytokine may be synthetic or naturally produced, or produced naturally or transgenically by cells placed at the tissue site 102 or in the scaffold 112.
The scaffold 112 may include, without limitation, calcium phosphate, collagen, PLA/PGA, hydroxyapatite, carbonates, and/or processed allograft materials. In another embodiment, the scaffold 112 may be used to release at least one therapeutic or prophylactic agent to the tissue site 102 by binding at least one therapeutic or prophylactic agent to the surface of the scaffold 112. For example, an antibiotic may also be applied to the scaffold 112, which is then released to the tissue site 102.
In some embodiments, the scaffold 112 is a porous material that includes a plurality of open chambers or "pores" that are connected by flow channels to allow fluid communication between the pores. The size, shape, or interconnectivity of the pores may be uniform, random, or patterned, and may be altered to enhance or control cartilage formation, response, repair, or host integration. Further, the size, shape, or interconnectivity of the pores in the scaffold 112 may be altered to enhance or control the integration of newly formed cartilage 108 with surrounding healthy tissue at the tissue site 102. In various embodiments, the scaffold 112 has a high void-fraction (i.e., a high content of air). It is desired in some embodiments that the pores are designed to allow the attachment of infiltrating cells to induce new cartilage formation. As explained above, the pores and flow chambers may be seeded with chondrocytes or other cell types in advance to promote cartilage formation. The flow channels in the scaffold 112 also facilitate distribution of fluids provided to and removed from the tissue site 102, including the transfer of reduced pressure to the tissue site 102.
In one embodiment, the scaffold 112 is made primarily of an open pore material that includes a plurality of pores fluidly connected to adjacent pores, where a plurality of flow channels is formed by and between the open pores of the material. The variations in size and shape of the pores results in variations in flow channels and can be used to alter flow characteristics of fluid through the material. In some embodiments, the scaffold 112 pore size ranges between 25 μm and 500 μm. In other embodiments, the pore size is between 50 μm and 250 μm. In additional embodiments, the pore size is between 50 μm and 150 μm.
The scaffold 112 may be formed of any biocompatible material, i.e. a material that does not elicit any undesirable local or systemic effects in vivo. A biocompatible scaffold 112 should also have the mechanical and biochemical properties that provide adequate support for tissue growth and cell proliferation. The materials can be characterized with respect to mechanical properties such as tensile strength using an Instron tester, molecular weight by gel permeation chromatography (GPC), glass transition temperature by differential scanning calorimetry (DSC) and bond structure by infrared (IR) spectroscopy. The material may also be characterized with respect to toxicology by, for example, mutagen tests, e.g. involving an Ames assay or an in vitro teratogenicity assay, or biochemical, cell, or implantation studies in animals for immunogenicity, inflammation, release or degradation.
In one embodiment, the scaffold 112 is formed of a bio-inert material, i.e., a material that does not elicit any response in vivo and does not bioabsorb or otherwise degrade in vivo. In another embodiment, the scaffold 112 is formed of a bioabsorbable material as that term in defined above. Regardless of whether the scaffold 112 is bioabsorbable or bio-inert when it contacts the tissue site 102, the scaffold 112 may also be biocompatible. If the scaffold 112 is made of bioabsorbable materials, the materials may be designed to degrade within a desired time frame. In one embodiment, the desired degradation time frame is six to twelve weeks. In another embodiment, the desired degradation time frame is between three months and one year. In yet another embodiment, the desired degradation time is greater than a year. Further, in some embodiments, scaffolds 112 made of bioabsorbable materials may degrade in a manner related to the molecular weights of the materials used to make the scaffold 112. In those embodiments, scaffolds 112 comprising a higher molecular weight material often retain structural integrity for longer periods of time than scaffolds 112 comprising lower molecular weight materials.
The scaffold 112 may be formed by melt-spinning, extrusion, casting, or other techniques well known in the polymer processing area. Preferred solvents, if used, are those which are removed by the processing or which are biocompatible in the amounts remaining after processing. Examples of polymers which can be used to form scaffolds 112 include natural and synthetic polymers. Synthetic polymers that may be used include, but are not limited to, bioabsorbable polymers such as polylactic acid (PLA), polyglycolic acid (PGA), polylactic-coglycolide acid (PLGA), and other polyhydroxyacids, polycaprolactones, polycarbonates, polyamides, polyanhydrides, polyamino acids, polyortho esters, polyacetals, degradable polycyanoacrylates and degradable polyurethanes, as well as a polylactide-coglycolide (PLAGA) polymer or a polyethylene glycol-PLAGA copolymer. Examples of natural polymers include, but are not limited to, proteins such as albumin, collagen, fibrin, and synthetic polyamino acids, and polysaccharides such as alginate, heparin, and other naturally occurring biodegradable polymers of sugar units. The polymeric blend may also include without limitation polycarbonates, polyfumarates, and capralactones.
In some embodiments, the bioabsorbable scaffold 112 is made of PLA, PGA or PLA/PGA copolymers. PLA polymers may be prepared from the cyclic esters of lactic acids. Both L (+) and D (−) forms of lactic acid can be used to prepare the PLA polymers, as well as the optically inactive DL-lactic acid mixture of D (−) and L (+) lactic acids. PGA is the homopolymer of glycolic acid (hydroxyacetic acid). Typically, in the conversion of glycolic acid to polyglycolic acid, glycolic acid is initially reacted with itself to form the cyclic ester glycolide, which in the presence of heat and a catalyst is converted to a high molecular weight linear-chain polymer. It is also contemplated that the scaffold 112 may be felted mats, liquids, gels, foams, or any other biocompatible material that provides fluid communication through a plurality of channels in three dimensions.
The drape 114 covers the reduced pressure dressing 110 and serves as a semi-permeable barrier to transmission of fluids such as liquids, air, and other gases. The drape 114, which in some embodiments provides structural support for the reduced pressure dressing 110, may be coupled to the reduced pressure dressing 110 or the manifold 111 using any technique, including via an adhesive. As used herein, the term "coupled" includes coupling via a separate object and includes direct coupling. The term "coupled" also encompasses two or more components that are continuous with one another by virtue of each of the components being formed from the same piece of material. Also, the term "coupled" may include chemical, such as via a chemical bond, mechanical, thermal, or electrical coupling. Specific non-limiting examples of the techniques by which the manifold 111 may be coupled to the drape 114 include welding (e.g., ultrasonic or RF welding), bonding, adhesives, cements, etc. In alternative embodiments, the drape 114 is not a separate, attached structure, but instead the manifold 111 itself may include a lining of impermeable materials that functions the same as the drape 114.
The drape may be any material that provides a pneumatic or fluid seal. The drape may, for example, be an impermeable or semi-permeable elastomeric material. "Elastomeric" means having the properties of an elastomer. It generally refers to a polymeric material that has rubber-like properties. More specifically, most elastomers have elongation rates greater than 100% and a significant amount of resilience. The resilience of a material refers to the material's ability to recover from an elastic deformation. Nonlimiting examples of elastomers include natural rubbers, polyisoprene, styrene butadiene rubber, chloroprene rubber, polybutadiene, nitrile rubber, butyl rubber, ethylene propylene rubber, ethylene propylene diene monomer, chlorosulfonated polyethylene, polysulfide rubber, polyurethane, EVA film, co-polyester, and silicones. Specific examples of drape materials include a silicone drape, 3M Tegaderm® drape, acrylic drape such as one available from Avery Dennison, or an incise drape.
In operation, the system 100 is used to stimulate formation of cartilage at the tissue site 102. A caretaker can apply a chondrocyte or chondrocyte precursor to the tissue site 102 or the reduced pressure dressing 110, and then apply reduced pressure to the tissue site 102 via the manifold 111 and the scaffold 112 for a time sufficient to cause new cartilage formation at the tissue site 102. The application of reduced pressure can result in the flexible drape 114 compressing and conforming to the surface of the tissue site 102 as air is removed from within the space between the drape 114 and the tissue site 102. In some applications, the system 100 may be used to cosmetically alter tissue having cartilage, such as a nose or ear. Cartilage may also be harvested on one mammal and then transplanted to another mammal, e.g., growing a nose or ear on a mouse for transplantation to a human. The system 100 may also be applied to a cartilage wound 106 and used to at least partially fill the wound 106.
The system 100 may also allow effective control of fixation, temperature, pressure (and its associated gradients for vital gases such as oxygen), osmotic forces, oncotic forces, and the addition or removal of various nutrients and pharmacological agents. Still further, the devices to apply reduced pressure in the current system and methodology may be enabled to transfer elements for the manipulation of gas and liquid pathways by preprogrammed, coordinated influx and efflux cycles. Such cycles would be designed to maintain the desired integrity and stability of the system while still allowing variations in multiple forces, flows, and concentrations within tolerated ranges.
The system 100 may also be configured to deliver fluid, liquids or gas, to the tissue site 102. In this embodiment, a fluid supply 124 for delivering a fluid 125 to the tissue site 102 fluidly communicates with the reduced pressure dressing 110 by a conduit 126 that may be connected directly to the reduced pressure dressing 110 (not shown) or indirectly via the conduit 118 which requires the use of valves 127 and 128 for controlling the delivery of reduced pressure from the reduced pressure source 116 and/or fluid 125 from the fluid supply 124, respectively. The fluid supply 124 may be separate from, attached to, or integrated within the reduced-pressure source 116. The fluid supply 124 enables treatment procedures to infuse the tissue site 102 with fluids to flush contaminants, counter infection, or promote tissue growth in the wound 106. Thus, the fluid supply 124 can be used to deliver various irrigation fluids, growth factors, antibiotics, anesthetics, antibacterial agents, antiviral agents, cell-growth promotion agents, or chemically active agents to the tissue site 102. The fluid supply 124 can also be used to deliver gaseous fluids to the tissue site 102 for a similar purpose including, for example, the delivery of sterile air in small quantities to promote and maintain the therapeutic effect at the tissue site 102 with or without the reduced pressure being maintained.
Referring to
The manifold is then delivered to the tissue site (step 202). Further, depending upon the embodiment, conduits to deliver reduced pressure, fluids, gases, or air may be connected before or after the manifold is delivered to the tissue site. If the tissue site is located underneath the skin of the patient, the manifold may be delivered to the tissue site by insertion into the body through the skin of the patient and through any interstitial tissue.
In some embodiments, it is contemplated that the tissue site has insufficient space to insert a manifold. In these embodiments, a device may be inserted that creates a void. For example, this device may be an inflatable device. Once a void is prepared, the manifold may then be delivered.
The main distribution surface of the manifold is then positioned adjacent to the tissue site (step 203). A reduced pressure is then applied to the tissue site (step 204). The reduced pressure may be applied continuously or in an intermittent fashion. Further, it is contemplated that the reduced pressure may be alternated with delivery of fluids, air, or agents that promote healing or regeneration as previously discussed.
The length and force of the reduced-pressure therapy may depend upon various factors determined appropriate by a caretaker, such as previous experience, connective tissue regeneration rate, and the like. The manifold may be removed upon partial or complete regeneration of the cartilage (step 205).
In some embodiments, the open pores or flow channels of the scaffold may be designed to promote a certain connective tissue growth in a particular three-dimensional shape. Thus, in one embodiment, the scaffold may be designed to promote cartilage growth on the surface of the body such as, for example, an ear. Referring more specifically to
As indicated above, the scaffold 312 may be placed adjacent to, in contact with, or substantially over the tissue site 302 to promote the growth of the cartilage in the cartilage wound 306. The scaffold 312 is a three-dimensional porous structure that provides a template for cell growth of the cartilage within the wound 306. The shape and flexibility of the scaffold 312 may be selected based on the desired shape of the ear 301 as indicated by the dashed line on the reduced pressure dressing 303. In one embodiment, a mold (not shown) may be used to form the scaffold 312 into the desired shape. Once the mold is created to fit the ear 301 at the tissue site 302 with the missing portion, it can be used to form the scaffold 312 into the three-dimensional shape desired to repair the cartilage wound 306. As indicated above, the scaffold 312 may contain chondrocytes or a coping may be applied directly to the cartilage wound 306. When the reduced pressure dressing 303 including the scaffold 312 is positioned within the void of the cartilage wound 306, the drape 314 is positioned to cover the reduced pressure dressing 303 as described in detail above. Reduced pressure therapy can then be applied by use of the reduced-pressure source (not shown) via the conduits 118 fluidly coupled to the reduced pressure dressing 303.
In another embodiment, the mold may be positioned over the cartilage wound 306 creating a void that may be filled with a fluid containing chondrocytes that is delivered by a fluid supply (not shown) via the conduit 118 or other independent supply of fluid. After the fluid fills the void between the mold and the cartilage wound 306, the fluid hardens to form the three-dimensional scaffold 312 that assumes the desired shape for the regenerated cartilage at the tissue site 302. The scaffold may also be seeded with chondrocytes after hardening.
Other embodiments within the scope of the claims herein will be apparent to one skilled in the art from consideration of the specification or practice of the invention as disclosed herein. It is intended that the specification, together with the examples, be considered exemplary only, with the scope and spirit of the invention being indicated by the claims, which follow the example. An illustrative embodiment is described in the following example.
Cartilage formation was observed in response to the application of reduced pressure therapy to the surface of intact cranial periosteal membranes. These observations are of significance in that cartilage formation in response to a therapy is unique and of great interest in the field of tissue engineering. These formations were observed in the absence of scaffold materials and only with the application of reduced pressure. No cartilage formation was observed in controls not subjected to reduced pressure.
Cartilage degeneration caused by congenital abnormalities or disease and trauma is of great clinical consequence. Because of the lack of blood supply and subsequent wound-healing response, damage to cartilage generally results in an incomplete repair by the body. Full-thickness articular cartilage damage, or osteochondral lesions, allow for the normal inflammatory response, but result in inferior fibrocartilage formation. Surgical intervention is often the only option. Treatments for repair of cartilage damage are often less than satisfactory, and rarely restore full function or return the tissue to its native normal state. This Example demonstrates the induction of new cartilage from periosteum using GranuFoam® and reduced pressure treatment.
A foam manifold and reduced pressure were evaluated for their ability to induce the periosteum to synthesize new cartilage. The intact, undamaged crania of rabbits were exposed. A GranuFoam® (KCI Licensing, Inc., San Antonio Tex.) foam dressing was applied to the bone. With some treatments, the foam-covered bone was also subjected to reduced pressure. After treatment, the treated bone was subjected to paraffin embedding, sectioning, and staining to evaluate the effect of the treatment on new bone formation.
In view of the above, it will be seen that the several advantages of the invention are achieved and other advantages attained. As various changes could be made in the above methods and compositions without departing from the scope of the invention, it is intended that all matter contained in the above description and shown in the accompanying drawings shall be interpreted as illustrative and not in a limiting sense.
All references cited in this specification are hereby incorporated by reference. The discussion of the references herein is intended merely to summarize the assertions made by the authors and no admission is made that any reference constitutes prior art. Applicants reserve the right to challenge the accuracy and pertinence of the cited references.
Citations de brevets
Citations hors brevets
Référencé par
Événements juridiques
Image d'origine
Faire pivoter


text:
Saint Joan[Paperback]
(5 ratings)
- Format:
- Paperback
- Pages:
- 192
- Publisher:
- Penguin Books Ltd
- Publication Date:
- 25 January 2001
- Category:
- Plays, playscripts
- 9780140437911
Showing 1-4 out of 6 reviews. Previous | Next
Would be 5 stars but anyone who writes a preface of 50 pages (in very small print) for a play of 100 pages (in normal print) is absurdly arrogant, and especially when they try to claim that this particular story is a melodrama and not a tragedy. The play itself is, in fact, clearly a tragedy--St Joan is a noble character (a chaste teenage girl who leads armies in a faltering independence movement and inspires them to victory), brought down by a fatal flaw (burned after insisting, through pride and obstinacy, that she should go take Compeigne even when King Charles, the Archbishop, and her co-captain Dunois say they will offer no protection, then refusing, during her trial, to comply with the demands made of her by the English and the Church), with pity and catharsis cleansing the audience's emotions at the end (where everything about her burns except her heart, she is given two sticks with which to make a cross by an English soldier, she saves a life by not letting a cross burn in a man's hands when he brings it near her, and her ghost appears to a bunch of apologetic characters twenty-some-odd years later).I would say it's one of the best plays I've read, and I've read many of them, Aeschylus, Sophocles, Euripides, Aristophanes, Shakespeare, Milton (Samson Agonistes), Moliere, Addison, Chekhov, Sheridan, Goethe, Synge, O'Neill, Williams, Kushner (ugh!), and so on and so forth...I highly recommend it for 8th-10th grade students, and I know that it was assigned when I was in high school (don't tell anyone I didn't read it then!).
I enjoyed the lengthy preface, which should by all rights be its own work. Shaw's arguments about "toleration" and the relationship between genius society were especially thought-provoking. Why should we take exception to what seemingly contradicts or overturns our preconceptions, if not because we simply don't understand? Feels like I've heard this argument so many times, but never phrased like Shaw puts it.
The play 's the thing. Saint Joan is an excellent example of Shaw's work and, I think, that excellence coupled with the time of Joan's becoming a saint gave Shaw the Swedish Merit Badge. Shaw's preface is too clever by half and the self important lecture can be skipped with no real harm to understanding the play. The play itself is notable for a lack of villians. That makes it extraordinary and much of the dialouge is skilled and thoughtful.
I did not know much about Joan of Arc before I read this. The book really made her real for me. Of course Shaw did not "know" Joan, but he portrays her in such a real and believable way that I was continuously comparing the character to people I have met in my life. I realized that whether or not Shaw was close to the mark or not, Joan had to be an exceptional person. One who I would have liked to have met.
Reviews provided by Librarything.
No reviews here.
Also by George Bernard Shaw
Major Barbara
eBook (EPUB)
Plays Unpleasant
eBook (EPUB)
Heartbreak House
eBook (EPUB)
Saint Joan
eBook (EPUB)


text:
- ‹
- 11 of 12
- ›
- Start Over
Lisa Canning
Mount lighting directly on a headboard.
"In a small space, I love as little clutter as possible," says Toronto-based interior stylist and HGTV contributor Lisa Canning. "Lights built into a headboard save tabletop space, and niches painted in attractive colours act as a functional focal point."
Comment Guidelines
We welcome your feedback on Houseandhome.com. H&H reserves the right to remove any unsuitable personal remarks made about the bloggers, hosts, homeowners and/or guests we feature. Please keep your comments focused on decorating, design, cooking and other lifestyle topics. Adopt a tone you would be willing to use in person and do not make slanderous remarks or use denigrating language. If you see a comment that you believe violates any of the guidelines outlined above, please click "Flag as inappropriate." Thank you.


text:
Mica the border collie follows her nose to a career in search and rescue
Courtesy photo
Mica searches for items with human scent in a pile of rubble off Chickasaw Road in Hagerman.
Tess Townsend
Record Staff Writer
"Go search."
Mica wanders the living room, sticking her nose into corners and sniffing. She lies down next to a cardboard box.
The box is one of a few lying around the home of Diane Whetsel and Cathy O'Dette in Roswell. Whetsel and O'Dette were in the process of moving to North Carolina at the time of Mica's demonstration one week ago.
Whetsel tells Mica she is close but must continue looking.
The quest resumes and soon after, Mica lands on the object of her search. She lies down next to a shelving unit that holds a small open jar of teeth Whetsel collected from dentists' offices.
Whetsel trains dogs who assist law enforcement, military and emergency personnel in searches for people, bombs and other subjects. Recently retired from work as a corrections officer at the Roswell Corrections Center, Whetsel also runs the Sage Foundation for Dogs Who Serve, a non-profit that raises funds to cover medical treatments of search dogs.
Mica, a 2-year-old border collie, is being trained by Whetsel to become a search-and-rescue dog. Specifically, Mica is learning to locate human Login to read more
Related Posts
Leave a Reply
You must be logged in to post a comment.
« Wounded warriors get hero's welcome Market brings the world to Roswell »


text:
I recently discovered AIKYOU, a green lingerie label with a healthy attitude toward small breasts.
AIKYOU means charm, love and respect in Japanese, but the brand was developed in Germany by Bianca Renninger and Gabriele Meinl who wanted to cater for women who prefer an un-pushed-up yet feminine look, even with a smaller bust. The brand caters for women who wear AA up to B cup bras.
The never-out-of-stock collection uses clear, confident, bikini inspired lines, and omits underwires and back fastening hooks. Designs fit perfectly under a variety of top shapes, from plunging v-necks to racer backs – there are even matching AIKYOU shirts for those who obsess about hiding bra straps altogether!
AIKYOU lingerie is comfortable and kind to the skin for every day wear, and simply perfect for those who enjoy yoga and pilates.
The soft lingerie made from Fairtrade organic cotton is so delicate it is like a second skin. All production is done in an ethical manner and every piece of AIKYOU lingerie sold, contributes to their annual donation to the Global Volunteer Network.
Have you tried AIKYOU lingerie yet? Do you wear small cup lingerie and have any recommendations?


text:
Pool Hours and Contact Information
Membership Information
New Members
Current Members
Vested Members
Registration and Payment
The FUN we have
Guest Passes and Rules
Swim Lessons
Swim Team
Upcoming Events
Have a Party
Supporting our Members
Job Opportunities
Board of Trustees
Board Meeting Minutes
Chaise Lounge and Chair Policy
Special Projects
Remember me
Forgot password
GVRC is installing a heater
coming Summer 2015!!!!
Upcoming events
In Search of....
05 Mar 2015 • GVRC
GVRC 50th Anniversary Celebrating all Season
23 May 2015 11:00 AM • GVRC
Pool does not open unless the air temp is above 70. As always pool closing is up to the of manager on duty.
GVRC is a private (member-owned)
club located on twenty secluded acres in Beavercreek Ohio. The 25-meter swimming pool, 180,088 gallons, includes a diving well and a beginning swimmer's area. A wading pool is available for children under the age of 5 years. Playground equipment, a gaga pit, sand box, sand volleyball and a wooded picnic area adjoin the pool. The pool operates a snack bar for the convenience of the
members. Swimming
lessons and swim team are available for interested members.
The pool is open daily from Memorial Day weekend through Labor Day weekend each year. Membership is limited.
Greene Valley Recreation Club
Beavercreek, Ohio
Powered by
Wild Apricot
Membership Software


text:
Register now for free, or sign in with any of these services:
Mr. Tittle exactly what makes you an expert over all of the biologists and others who have been part of this plan? Your organization constantly gets exposed for what it is. A radical left wing bunch of environmental extremists. You are against every form of development or alternate energy use that would wean us from foreign oil including natural gas and the exploration of our own oil production. You are so worried about preservation of the Highlands yet could give a rats a## about all of the taxpayers who must be the shepherds for the rest of the state and bear the cost. Why are you not in front of a water tax for all users? It also boggles my mind that the anti bear hunt folks have no problem with deer hunting?? The fact is that the bear population has exceeded the carrying capacity of the available open space and hunting has proven to be the most cost effective means of necessary population control. Your suggestion to control the habitat is trying to close the door after the horse is out. If you have an alternative method to population control bring your check book.


text:
Southwestern Community College's Red Oak Center offers college credit, adult education, GED and Adult Basic Education classes, and customized training for local businesses and industries.
In addition to on-site classes, distance learning opportunities are available using the Iowa Communications Network (ICN), and online classes through the Iowa Community College Online Consortium. The Red Oak Center has nine classrooms including two ICN rooms and a 15-station computer lab.
In 2002, the Red Oak Technology Center opened through a cooperative effort with Red Oak Community Schools, the Red Oak Industrial Foundation, Buena Vista University, Bellevue University, and individual, business, and industrial donors. The Technology Center provides classroom space for Southwestern's Career Academy programs and science classes.
Southwestern Community College Red Oak Center
Phone: 712.623.2541
Fax: 712.623.4534


text:
This species is listed on the International Union for the Conservation of Nature (IUCN) Red List as vulnerable with a decreasing population trend. It is thought that numbers have decreased by a third in the past 21 years.
It is listed on appendix II of the Convention on International Trade in Endangered Species (CITES).
Humans pose the main threat to Cryptoprocta ferox. They are hunted and persecuted because of their exaggerated reputation as being fearsome, and their role as a pest - they are known to hunt poultry and are said to attack hogs and oxen.
There is also considerable superstition associated the species (Hawkins, 2008), (Pickrell, 2005).
This species' habitat is threatened due to collection of firewood and conversion to agricultural land, and is being fragmented due to selective logging (Hawkins, 2008).
Cryptoprocta ferox has no natural predators but is predated by feral dogs (Hawkins, 2008). Diseases such as rabies that are transmitted by introduced animals also threaten the species (Pickrell, 2005).