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Happy Holidays!
Friday, December 24th, 2010
Hoping you and yours have a great holiday and a wonderful new year! All the best, Mike, Erika, Jackson & Sadie.
Hoping you and yours have a great holiday and a wonderful new year! All the best, Mike, Erika, Jackson & Sadie.
Have a safe and happy holiday season! We'll see you in 2010 with new art and fun.
Go easy on that Eggnog.
They're on the way… hopefully we haven't missed anyone. If you'd like one, shoot us an email and I'll drop one in the mail.
I apologize for the slow down in posts. For those of you that don't know, I injured my arm at the beginning of June. The injury required surgery and I've been working through physical therapy since. The whole experience has been frustration as it's really slowed down what I've been able to accomplish… oh well right.
Anyhow… in keeping my posting some of my illustration favorites, here is another illustration I created for a cookbook. Surprisingly enough, pots and pans are fun to draw.
Why use the post office's boring change of address cards, when you can create your own.
Illustration for a McGraw-Hill elementary level text book.
Until I free up some time to build a proper area of the site to showcase my illustration work, I thought I'd post some of my favorite illustrations here for your viewing pleasure ;)
The following piece was commissioned by McGraw-Hill and published in an elementary level text book.
From our family to yours… have a healthy and happy holiday season. Thank you for your continued support and look for new murals and t-shirt designs in 2009.
Thank you to everyone who has supported us during our first year in business. Stay tuned for more custom kids murals and t-shirt designs in 2008. Have a happy, healthy and safe holiday season!
When I arrived home the other day, I was pleasantly surprised to find a box on the back porch containing copies of a book I illustrated awhile back called Silly Dog Tricks. It's always cool to get these boxes - first, for the obvious reason that it's pretty cool to see my name and work in print… but also because the illustrations are so often submitted independently of the text, and seeing it all come together for the first time in its final package is like an early Christmas present.
The book title accurately describes its content. Silly Dog Tricks is geared for kids, and it gives detailed instructions on how to teach your pup how to perform different stunts such as playing dead, walking on its hind legs, and stealing someone's wallet out of their back pocket (not sure about that one). It also includes a training clicker and squeaky toy… it's a pretty cool package.
For my part, I cranked out about 40 full-color illustrations of 4 different dogs in about a month. It was a pretty aggressive schedule, but I muddled through it like everything else in life. My wife was awesome, looking after our son while I spent late nights and weekends getting fur just right. She even went as far as naming each dog and referring to them by name (Abe, Bandit, Midnight and Flapjack) when checking in on my progress and bringing me that next cup of coffee. She's the best.
Anyhow, if you have a dog and a youngster, definitely check out the book.
You can browse a few pages from the book via Google.
Or buy the book through Amazon


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college football - Page 9
Cincinnati Uses Jump Pass Trick Play To Score Touchdown – VIDEO
College Football 2012 – Week 10 Recap
It was another crazy weekend in college football with Alabama and Notre Dame needing last minute rallies to survive, Oregon and USC giving us a PAC-12 shootout for the ages and the Heisman frontrunner leaving with an injury.
Here are all the highlights from an exciting weekend in the Top 25.
LSU Slips to #7 in BCS Rankings
My Harris Poll Vote – From the Bird's Nest
Alabama Rallies To Defeat LSU, 21-17
LSU Hosts Alabama
College Football 2012 — Week 10 Preview
Last week's showdowns knocked several teams from the ranks of the unbeaten and shook up the rankings. This week, we get two of the biggest games of the season, with Alabama-LSU and Oregon-USC setting the stage for conference- and national-championship runs.
But the excitement doesn't stop there. Here is what to watch for around the top 25:
This Week in the Sun Belt
College Football 2012 – Week Nine Recap
This week's rankings will look very different when the new AP Poll comes out following a Saturday full of upsets. Four Top Ten teams fell this week and five ranked teams suffered their first losses of the season. Meanwhile, Collin Klein and Manti T'eo boosted their Heisman chances while Alabama, Oregon, Kansas State and Notre Dame continued to make their case for a shot in the national title game.
Here are all highlights from a wild week in college football.

subset: commoncrawl


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Local Auto Racing Notebook: Kimball ends season in Fontana
Camarilllo native Charlie Kimball will end his season Saturday in the MAVTV 500 in Fontana.
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Read Comments From Our Recent Guests!
Click here to submit your review.
Always a positive experience
I've been staying at your motel for many years now and it is always a positive experience! The entire staff (including the manager, the ladies at the front desk, the maintenance men, and the housekeeping staff) are always so helpful and friendly! It says a lot about a business when you see the same faces working there year after year! The rooms and property are always clean and well-maintained. Miss Jovonn even remembered me and my daughter from previous years and took the time to give me a hug before we left! Your customer service is outstanding! Thanks for another great vacation-we'll see you again next summer!
We love the Flamingo
We love the Flamingo, it will always be our go to place when we visit Ocean City. We are always treated like family from all the staff. The rooms and price is fantastic! Thank you for a wonderful vacation. The Helton Family
Nice place
We only stayed one night in OC; this place had a great view, was very close to everything and the staff is great! The lady at the desk was very sweet and helpful. The bathroom in our room could have used some improvements and the refrigerator wasn't as clean as I would've expected; but for our short stay it was perfect.
excellent place!!
Stayed here with husband and our toddlers and lovedIt!! Staff is so nice rooms are clean pools are clean and nice,ocean view is great,location is amazing,will defiantly be returning!!
Best Staff in Town!
This motel is dated, but for the price, it just doesn't get any better! The staff are extremely friendly and always willing to help with anything you may need, including finding you a parking space at 2:00 am when all the spots are taken. The rooms are clean, the pools are nice, and the after-checkout "accommodations" are amazing! This was our fourth time staying here, and we'll be back again very soon!
Had A Great Time
We had a wonderful time, you always have the nicest place in Ocean City!
First time staying here
This motel was very clean and the staff was extremely pleasant. Definitely a satisfied customer. I will most likely stay here again on my next trip.
Absolutely love the Flamingo!
Every year we stay it gets better & better. See u guys later this summer. 5 stars!!
Wonderful stay!
We had a wonderful stay at the flamingo look forward to the next stay.
We have stayed here 3 years in a row and we love it!
We have stayed here 3 years in a row and we love it, thanks and God bless.


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SPRINGFIELD, Mo. -- Anthony Downing scored 24 points Tuesday night and Missouri State defeated Illinois State 62-55.
Marcus Marshall had 14 points for the Bears (5-11, 3-1 Missouri Valley), who shot 54 percent from the field in the first half in building a 32-25 halftime lead. Missouri State finished the game at 47 percent.
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Jackie Carmichael led Illinois State (9-7, 0-4) with 21 points and 12 rebounds. Johnny Hill had 14 points. Jon Ekey scored eight points but no other player had more than four points for the Redbirds, who had won four straight before entering MVC play.
Missouri State didn't have a field goal in the last 4 minutes, but closed the game with seven free throws in the final 1:23, six of them by Downing.


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ENGL 339: Shakespeare
Dr. Debora B. Schwartz
English Department, California Polytechnic State University
Henry V: Video Questions
Review General Instructions for Personal Responses to the Required Video Screenings.
All video assignments are to be submitted to your PolyLearn Group Discussion Forum. For each assigned video, you will answer each of three questions TWICE:
Both your ungraded Pre-Video Analysis responses with your own thoughts on the play and your graded PR analyzing the assigned video should be clearly numbered (questions 1a, 1b, 2 and 3). Remember that for the ungraded pre-video analysis posting, you are answering the questions based upon your own informed understanding of the text, as if you were a director planning your own prodcution of the play. Your graded PR should answer the same questions as you feel the director of the assigned film might have answered them.
- once for yourself, prior to seeing the video, based upon your own informed understanding of the play; this "Pre-Video Analysis" posting is ungraded, but it is required for you to get credit for your graded PR. It should be completed before you screen the required film and must be posted to your Group Discussion Forum before the class meeting when the required video will be discussed.
- a second time after screening the required video, Laurence Olivier's 1944 film of Henry V. (You must screen this film in its entirety, either at a scheduled group screening or on your own, prior to the scheduled video discussion on the last full class day devoted to Henry V). The second time, answer the questions as you believe director and star Laurence Olivier would, based upon your attentive viewing of the video and informed knowledge of the text. (Be sure to identify the film clearly by Director's name and year produced.) Your graded PR Video Analysis of the assigned film is due no later than 10 PM on the Friday following class discussion of the required video and clips from other filmed versions of the play.
As you write up these questions, take care to state your interpretation clearly (it is your thesis) and support it textually (cite specific textual passages with act, scene and line numbers). For the video, cite both specific non-textual details from the video screened AND at least one key speech or scene which the director may have been thinking of when making these choices about how to film the play.
General Questions to answer prior to screening ANY Shakespeare video:
1a) What is the central issue in this play? (What is it really about?) Upon what speeches/textual passages is my (or is the director's) understanding of this issue and its central importance based?
1b) What non-textual details would I use (or are used in the video) to get this message across? Consider the contributions of director, actors, set and lighting designers, costumers, choreographers, musicians, cinematographers, etc. -- NOT elements common to ANY production of the play (such as plot lines or speeches that are in the script regardless of the director's interpretation).
Specific video questions for Olivier's Olivier's Henry V:
3) King Henry is full of contrasts and contradictions -- which makes for a rich and complex text, but is a problem for the director. Based upon what you see as the central issue in the play, are there speeches or scenes that you would downplay as director? How would you handle them? (with humor or irony? by emphasizing other scenes or elements that are more central to your interpretation? by eliminating them completely?) The second time through, tell me how you think Laurence Olivier would respond to this question, based upon his treatment of the script. (Note key speeches and scenes which are edited, elided, transformed or omitted from his considerably shorter version of the play!)
4) What look would you (or does Olivier) go for, and why? (See e-reserve reading with Olivier's comments on making Henry V.) How much realism/pageantry? (stylized? gritty? bloody? glorious?) Contemporary or period dress? (and what period?) How would you handle the Chorus? (For an interesting contrast, see Branagh's Henry V, an equally brilliant but very different film!)
Click here for Henry V Study Questions
Click here for information on Shakespeare's Histories
Contents of this and all linked pages Copyright Debora B. Schwartz, 1996-2012Return to ENGL 339 Home PageSend me mail!


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Narrow your search
We put the latest high-end desktop PC gaming cards to the test in the CNET Labs.
From long-expected new products like the Samsung Galaxy S6 and HTC One M9 to surprises like the Huawei Watch and HTC Vive, here's everything you missed on the day before the Mobile World Congress officially opened.
A new eight-core CPU, plus the X99 chipset, both aim at high-end PC gamers.
Micron Technology is a very big chipmaker that's closer to Apple than it ever has been.
Intel thinks there's a future in the desktop PC. And it tried to prove that this week at the Game Developers Conference.
The Korean electronics giant's low-power DDR4 memory chips, due to ship in 2014, will help lift a key performance bottleneck in today's mobile devices. Samsung says the new chips are faster and use less power, too.
Samsung has unveiled a new mobile chip, and it could mean big things for its next flagship, the Galaxy S5.
A 56-page document has detailed Microsoft's plans for the next-gen console.
Crave's Christopher MacManus takes an in-depth look at an enormous leaked 56-page Microsoft Xbox road map to 2015 Powerpoint file that dropped over the weekend.
Micron Technology tomorrow is set to unveil a type of hybrid memory that it claims will make standard memory chips used in PCs today 20 times faster.


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With a history dating back to 2004, BiMS has established a reputation for international standard teaching which has made us one of the top institutes for business management. BiMS strives to equip students with the right tools to meet the global challenges of today.
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Hornets beat Bears in the air
West Oso coach Mark Guess likened his opponent Friday first to a power tool, then to a fairy tale character. But at their core, his foes were simply Hornets doing what Hornets do best - taking to the air and stinging every chance they get.
"That's what happens when you run into a buzz saw," Guess said after Flour Bluff's convincing 38-6 win. "We woke the sleeping giant tonight."
With most of the crowd expecting a ground battle, the Hornets won the game in the strong, swirling winds above Bear Stadium. Junior quarterback R.J. Long threw for 211 yards and three touchdowns, including a pair of first-half scores to senior Ryan Flowers.
"We knew when we got the wind, we were going to throw it. We have to be able to throw the ball in our district," said Hornets coach Darrell Andrus, whose squad went without a completion in its first loss of the season, at home last week against Ray.
All but one of the 24 passes attempted in the game went with the wind as the teams keyed on stopping the rush.
"We did a good job of trying to contain (Long)," Guess said. "He killed us with his arm, not his legs."
The ground attack for both teams was so rusty that it took reserve running back Octavio Flores just two fourth-quarter touches to become the game's leading rusher.
Josh Brunemeier had two touchdowns for Flour Bluff (3-1), while Lopez had the lone score for West Oso (2-2), a fourth-quarter drive that started at the Bears' own 20-yard-line and ate up 41/2 minutes.
The Hornets defense held West Oso without a first down until midway through the third quarter. The Bears entered the fourth quarter with negative total yards, and gained all 115 of their total yards on its two drives.
The only turnover of the game came on West Oso's last carry, one yard shy of the end zone with just over two minutes to play.
RUSHING - FB, Octavio Flores 9-86, Robert McCormick 8-28, Long 12-28, Zach Hillenberg 4-20, Bryan Twaits 2-7, Josh Brunemeier 3-2; OSO, Shedrick Howard 15-44, P.J. Lopez 8-31, (No. 2) 2-25, Jerald Lewis 4-13, William Tortorello 4-5, Andrew Leon 1-(-1), David Castillo 1-(-2).
PASSING - FB, R. J. Long 11-17-3-211; OSO, P.J. Lopez 1-5-0-26, William Tortorello 0-2-0-0.
RECEIVING - FB, Ryan Flowers 5-99, John Brunemeier 2-41, Zach Hillenberg 1-39, Justin Brandt 1-18, Stephen Shores 1-8, Robert McCormick 1-6; OSO, David Castillo 1-26.
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2013 [RS-SOPHOMORE]:Appeared in 29 games in 2013, started in 22… hit .238 on the year with a .381 slugging percentage… Drove in 13 runs on the year and recorded 8 extra-base hits, including two home runs… Went 6-for-16 in a four game stretch from 4/20 to 4/27 with eight RBI, three doubles, two home runs, one stolen base and four runs scored.
SUMMER 2012: Played for the East Texas Pump Jacks, helping to lead the squad to a Texas Collegiate League championship.
JUNIOR COLLEGE: Played at Howard College under head coach Britt Smith ... Hit .356 with 19 doubles, seven triples and five home runs ... Helped lead the Hawks to a conference championship.
HIGH SCHOOL: Four-year letterwinner at Mineola High School under head coach Heath Ragle ... Career .511 hitter with 20 home runs and a 15-5 pitching record ... Hit .535 with 35 hits, including eight doubles and 15 home runs, to go along with 30 walks his senior season ... Went 17-17 in stolen bases as a senior ... Posted a 9-2 record, 118 strikeouts and a 1.43 ERA as a pitcher his senior season ... As a senior, named district MVP, team captain, first team all-state catcher, three-time tournament MVP, Rawlings All-American, Louisville Slugger All-American and first team All-East Texas ... Other honors include second team all-state (2009), district MVP (2009) and Louisville Slugger All-American (2009). Also a four-year letterwinner in football, earning first team all-district honors as a quarterback in 2008 and running back in 2009.
PERSONAL: Full name is Eric Colton Bickerstaff ... Born in Sulphur Springs, Texas ... Parents are Sherry Thompson and Cecil Bickerstaff ... Has two brothers, Seth and Chase ... Brother, Chase, was a RHP at Nebraska ... Nutrition major.
Sooner Sports Powered by FOX Sports is a multi-platform network that provides distribution of 1,000+ hours of Sooner sports programming annually on a variety of FOX Sports outlets, including FOX Sports Oklahoma, FOX Sports Southwest, and FOX College Sports. Additionally, the partnership between the University of Oklahoma and FOX Sports includes a comprehensive digital component featuring extensive "all-access" content not televised on FOX Sports networks including live streaming, archived games, and exclusive materials.


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When you think of Notre Dame football, you think of independence. Why would Notre Dame change that?
The Big 10 just added Nebraska and possibly Missouri. Now they are trying to get Notre Dame into the conference.
Notre Dame AD, Jack Swarbrick said Notre Dame doesn't want to go to the Big 10 right now, but will consider it later on.
The Irish are currently under contract with NBC to show there games until 2015. After that, I expect Notre Dame to go to the Big 10.
That will ruin the tradition of independence for Notre Dame. They could lose all of there great rivalries with USC, Boston College, and Navy.
Notre Dame though would need the Big 10 after that. The conference has a lot of money Notre Dame could feed off of.
Also, Notre Dame could be in one of the best conferences in the NCAA.
For Notre Dame fans like me, it would be a sad day for it to happen. Notre Dame has always been independent and it has been a tradition for them to not be in a conference.
Notre Dame is one of the most hated teams in the NCAA, but is one of the most recognizable.
Notre Dame to the Big 10 will eventually happen, but Notre Dame is recognized as independent.
It will be a sad day when Notre Dame leaves independence for the Big 10.


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Palm Beach Atlantic University's Lady Sailfish volleyball team embarked on an opportunity of a lifetime on Sunday, playing and dancing with the aging-but-still-hip band the Beach Boys.
The Lady Sailfish played the Beach Boys in several volleyball games at the Lake Worth public beach, and were even challenged to a rematch by the California-bred band, according to Coach Bob White. That night, the cheerleading team performed onstage with the band at the Kravis Center for two songs.
The volleyball team members didn't go easy on their celebrity opponents, as spikes and kills flew across the sand during the games. Spectators primarily consisted of men and women with cameras looking to get a picture of the famous band.
Coach White expressed excitement when asked about the event. 'It was a great opportunity to show the band young ladies who could really play volleyball and who were also great examples of women of faith," he said. "I think they were impressed with our team's enthusiasm and level of play. The girls loved rocking out to the classic Beach Boys tunes at the concert that night."
The cheerleaders, instead of cheering for sports, took to the stage to cheer with a band that has been touring and recording since their parents' and grandparents' generation. Backstage, they danced and had a great time, also meeting every member of the band.
"I felt like it was my 15 minutes of fame," said PBA freshman Rachel Vogency, part of the cheerleading team that went onstage with the Beach Boys for the songs Barbara Ann and Be True to Your School in front of a packed Kravis Center crowd. "It was just great to meet them and hear their stories, not to mention meeting John Stamos."
Stamos, most famous for his acting role on the television show Full House, performed with the band and posed for pictures with the cheer and volleyball teams after the concert. When he walked through the backstage hallway, only the PBA girls were heard saying, "Is that Uncle Jesse from Full House? Somebody, quick! Let's get a picture with him!"
The Beach Boys had been touring across Florida the previous week, and they said Palm Beach was one of their favorite stops. At the volleyball game, Bruce Johnston, whose first recording with the band was its incredibly famous California Girls and who won a Grammy for his hit I Write the Songs, said, "We love the Palm Beach area. We've been here many times and we've always wanted to come back."


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Is Emily B Flaunting An Engagement Ring?
Has Fabolous finally put a ring on it?
After 12 years of dating and having a beautiful 5-year-old son together, it looks as though Fab may have popped the question to Emily B. Over the past few weeks, she's been flaunting a new, classy ring on her wedding ring finger on Instagram with eyebrow-raising captions that hint that marriage may be in the future. On a recent post she wrote:
Change is necessary when we want to pursue a new direction in life. Change gives us hope for the future. Embracing change is not easy. It takes a new outlook on life, determination and perseverance. The change we expect may not happen immediately because real progress is slow. In time, if we change our mindset and actions we will make a significant difference in people's lives.
I wonder if that mindset change she's talking about is Fab, who back in 2012 said folks out there shouldn't hold their breath if they're waiting for him to jump the broom.
I don't think marriage is in the future for me right now man, I really don't. The thing about marriage is that I believe in it and don't believe in it. I think people put that ring and that paper and it messes up a good thing sometimes.
I didn't say I won't ever get married. If it presents itself and I'm ready to do that, I would. I think marriage is a great thing and I think a lot of people don't respect it the same way that I respect it.
Some people just want to get married because it's a nice thing to do. It's a way to show that you love somebody, but they don't see all of the things that come with marriage and the mind state it takes to be in a marriage. People will get married and get divorced three months later. I wouldn't want to move forward with something that I was unsure about on that high of a level.
It's a strong thing. It's a commitment with you, the lady, and God. It's something that you should look and feel like you are totally ready for and not just do it because it is the thing to do and, 'I want to make my friends jealous.'
Peep another pic below:
Beautiful ring!


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Is Jessica Simpson Financially Supporting Sister Ashlee?
Scott Disick Talks Baby Number 4 With Kourtney Kardashian
Is Meri Brown Quitting Sister Wives and Leaving Kody Brown?
Beyonce Isn't as Flawless as We Thought
What Does Kylie Jenner Look Like Without Makeup?
Kendall and Kylie Jenner Celebrate High School Graduation with Star-Studded Party
Is Kim Kardashian Pretending to be Pregnant?
The New Bond Girl is 50 and Here's Why That's So Important
Why Chinese Men Don't Go Bald - Every Bald Man Needs To See
Selena's Scandalous Selfie Sparks Drama
9 Blue-Haired Babes You Should Check Out
The Adorable Children of Reality TV Stars
Kristen Bell Leaves "Frozen" Voicemail For Ailing Fan That Will Totally Melt Your Heart
11 Problems Only Four-Eyed Girls Will Understand
Shannon Beador Drops Another Affair Truth Bomb
10 Low Paying Jobs To Avoid Out Of College
9 Fashion Brands That Are Made in the U.S.A.
Caitlyn Jenner Shares Magnificent Father's Day Photo
Want an A-List Wedding? 10 Celeb Wedding Officiants
Duchess Kate's Huge Allowance is Mind Blowing
Rob Kardashian Has Finally Resurfaced!
Did You know These Stars Were Born Rich?
Kylie Jenner Says She Has To Act Fake For The Kardashian Image
Is Kaitlyn Bristowe's Engagement Already Over?
Khloe Kardashian and Lamar Odom Make Divorce Official
Taylor Swift Stuns Everyone by Posting Sexy Bikini Pic
The Science of Willow & Jaden Smith
Separated at Birth! People Who Look Just Like Celebs
Kris Jenner Finally Meets Caitlyn Jenner Face-To-Face
This 9-Year-Old Model Is Being Called the "Most Beautiful Girl in the World"


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Hotels/lodging near Coligny Beach are shown in the list below ordered by distance (closest at the top). Explore our hotel guide to find lodging near Coligny Beach (Hilton Head Island SC) for your upcoming travels.
We show the best motels and hotels close to Coligny Beach so you can review the discounted Hilton Head Island SC hotels below and uncover the perfect hotel.
Lodging/Accommodations close by Coligny Beach
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Paris HotSpot – GangSta Blabla / Opportunity Playlist for #socent projects / Opportunités pour Padawan #socent
Yoho Pirates ! Here are some anouncements gathered by the Gang in Paris that could #boost your projects. The competition in french have a description in French.
Salut les pirates ! ( ça sonne moins bien hein ? ). Le Gangsta Blabla : Quelques news, concours, annonces qui pourraient vous intéresser pour vos projets et idées
Concours / Contests :
Concours SFR Jeunes Talents Entrepreneurs Sociaux – Deadline le 18 Janvier ! Un An d'accompagnement pour 8 lauréats – C'est par ici !
Dream It, Do it par Ashoka – Deadline Février ! 3000 euros à la clé pour les 14 – 22 ans qui ont de l'impact sous le capot!
Social Business Youngsters by Danone Communities. Submit your Social Business project to have full support from the D.C crew and Doc Yunus #bimboom
Stages / Chic Interships
Also on the Gangsta Blabla Paris HotSpot : Stage/ Intership @ la croix rouge in Paris in the innovation department with the fabulous clem di cioccio here's the description.
Coming up events the hotspot in Paris heard about :
- Paris Jan 17 : Leila from the Gang represents with a pechakucha during the Alters-Mardis entrepreneuriat Social
- Paris : Jan 21 3DS : create a collaborative consumption start-up in a week end
- Paris : Jan 24 : Soirée Sparknews avec le fondateur de BetterWorldBooks inscriptions ici
- Berlin : Jan 21 SenseCamp by the berlin MakeSense Gang
- Paris : Jan 31 – 9 MakeSense hold-ups with the Mouves mixing #socent and city officials to solve city challenges
- Paris : 1 feb – Entrepreneur Social de l'année par BCG
- Marseille : Feb 2 – 6 MakeSense Hold-Ups @ Euromed Management to solve the challenges of Social Tourism entrepreneurs with GK.
- Nice : Feb 3 – 4 Hold-Ups @ Skema Nice
Let's finish the Gangsta blabla with some good grooves.
untill the next one,
Christian live the Hotspot in Paris
That was MAAAAAAD! – MaD Forum 2012, HK
The Museum School-Breaking the walls of regular schools
Sometimes I'm dreaming of a world where the knowledge flies into the sky. You just have to raise your hands to grab it and to learn what you'd like. Don't you think you'll be much more enthusiastic to learn & that you'll learn much more?
Grabbing the knowledge of the world from where it's been and sharing it with the kids of world is what Pradeep Ghosh is intending. With Shibani, his wife, he has created an innovative model of schools. Breaking the walls of the regular school, it allows underprivileged children to access a high quality education.
Naandi Safe Drinking Water Program – Diving into the beauty of rural areas
Nanhi Kali : educating girl child for the welfare of the nation
Standing alone in front of this class crowded with bright and open eyes looking at us, we had no ideas what would be next. We could have tried to speak with them in english, they wouldn't have understood us. They could have tried to ask us question in hindi, we wouldn't have get it.
Anyway a nice atmosphere was being created! With the help of our hands as language we have created the connexion. Some minutes later they were all smiling and focused on their drawing. Hopefully Rathi from the Naandi Team has helped us and now they were drawing what they would like to do when they grow up. Houses, doctors, policeman, families were appearing on their paper. I then became "Didi" -their elder sister- and Luc was going from table to table to understand what they've drawing and learning at the same time how to say it in hindi.
At the same time, outside with the other class, Maelle, Remi and Guilhem were learning dances and games from these little girls. Then it was their turn to teach them back how to play to "1,2,3, soleil".
Every afternoon instead of hanging around in Delhi's street, hundreds underprivileged girls are invited to stay a bit longer in school learning, playing and sharing more time together. In many part of India, the arrival of a baby girl calls for mourning rather than celebration. Many Indian families don't even see the point in investing in their education. Believing that educated women form the foundation of a modern secular society Anand Mahindra has created in 1996 the Nanhi Kali project. He strongly believed that empowering the girl child education would result in huge benefits for the nation in the long term. In 2005, the Naandi foundation with the objective of providing 10 years of quality education to girls from economically disadvantaged families.
Nowaday the project currently supports the education of over 70,000 underprivileged girl children from poor urban, remote rural, tribal and conflict afflicted communities across 9 states of Maharashtra, Andhra Pradesh, Rajasthan, Chhattisgarh, Madhya Pradesh, Karnataka and New Delhi and Haryana. Experimenting with these little girl some new ways of learning through an after schooling system, they are offering these children a quality education.
The impact no surprise is already noticed. The drop out rates of girls have been curtailed to less than 10% within the programme compared to national level figures of 30% at Primary level and 70% at the Secondary School level.
Indian Tour : Naandi Midday Meal – Banishing hunger
About the author :
Hi there,
I'm Marie. I'm deeply interested by social innovation & education. I've been travelling with my cousins in North India where I've met inspiring social entrepreneurs changing the indian kids world : )
If you'd like to hack education, I'd be glad to get in touch with you! You can follow me on twitter @MarieLbrgne & share with me your wicked idea to change the kids world on facebook facebook.com/MarieLbrgne
Crowded rooms with empty bellies is what you will usally find in India government schools. Welcoming the kids from underpriviledged areas and lacking of budget, the education system doesn't seemed to be very efficient concerning malnutrition issues.
Could you imagine attending one day at school without eating at all, neither before or even at school?
Obviously Leena from the Naandi team can't and is willing to fight against this malnutrition issue. Within the Naandi Foundation, she has kickstarted a program called the Midday Meal. Its aim is to provide everyday a meal to the kids from underpriviledged areas during their school time.
A huge program spreading all around India and feeding millions of child. Very interested to discover more about it, Clémentine, Maelle and I went on the field. Read more…
Meeting social entrepreneurs from China
The past months, we've been very busy launching the movement in China, focusing on Beijing and Shanghai. That meant spending a lot of time meeting people, building partnerships (special thanks to the Social Resources Institute, the Peking University branch of ShARE and Xindanwei), meeting more people, and organize events.
In Beijing, the first Hold-ups have been organized for 2 local social entreprises: Healthy Baby SMS and 1KG More. It is now time to meet them!
- Healthy Baby SMS is a social enterprise working towards a safe and healthy motherhood for new and expectant mothers in China's migrant communities, by providing free health guidance through weekly text-messages and a SMS hotline. Currently in prototyping phase, HealthyBabySMS is run by medical students at Peking University and Harvard Medical School with a core passion for improving the health and lives of the most vulnerable migrant women and children in China. For more information, check out the website at: www.healthybabysms.org
If this video doesn't work, click here.
- 1KG More is a crowdsourcing platform which encourages people to participate in service projects in creative ways, with the goal of bringing sustainable improvements to education in China's less-developed areas. It is a online community focusing on back-packers, and founded in 2004, when Andrew was 31 and an ordinary staff of an IT company in Beijing. The idea was widely acknowledged in very short time, and 1KG consequently became one of the fastest growing social entreprise in China. Make sure to check out the website at: www.1kg.org
If this video doesn't work, click here.
This is just the beginning, so stay tuned, because there's much more coming from Asia…
Asia Tour- China – Xin Dan Wei – a cowo for innovation & change in Shanghai
First visit? click here to understand the MakeSense story.
Second visit? Well, welcome back Third visit? You should follow MakeSense live on facebook
Thanks to Habib bellaribi, member of the Gang kickstarting MakeSense in Shanghai, the first ever Hold-up in China took place @ Xin Dan Wei a supercool cowo for innovation & change. Xin Dan Wei was created by @theliuyuan and if you look at the video below you'll see that it's much more than a coworking space #creativecommons #open
This video interview have been realized a year ago in Shanghai during the Asia Tour.


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Voters have more than a president to elect
Unless one is living under a rock, there is little chance that an American over the age of 10 lacks knowledge of the presidential election on Nov. 6. In the massive attention to the presidential campaigns, many Americans have forgotten we are not only electing a president, but also voting on state and local officials as well as legal changes.
This is crucial. Political scientists know that much of what affects us in our daily lives does not come from the White House or Congress, but rather the state Capitol and county and city officials. We need to vote on all the local questions and candidates. Nov. 6 is more than the presidential election.
We Americans understand the importance of electing our officials. The problem is we often don't bother to vote. The U.S. Census Bureau estimates that fewer than 65 percent of eligible voters went to the polls for the November 2008 election. A smaller percent of West Virginians did so.
We need to do better. There are many choices in candidates and issues that affect us locally. Our state legislators are vital to the success of projects in Cabell and Wayne counties. Those now in office in the 5th Senatorial District, and the 16th and 17th Delegate Districts have helped our area greatly.
Aside from Huntington's mayoral race, where the position is not just ceremonial, we will be electing our entire City Council. Choose your district and at-large council members carefully. Not too long ago, we elected a Huntington City Council that was an embarrassment. We can't let it happen again.
One of the most important contests concerns the 14 candidates vying for the seven magistrate positions. Some incumbent magistrates have excellent reputations and should be re-elected; others are not as good. While it would be desirable to have increased educational qualifications for this position, that isn't going to happen. So, gather as much information as possible about these candidates. Previously, we came very close to electing a candidate who should never have been in a position to make judicial decisions.
There are three Huntington Charter Amendment issues on the ballot. All three make sense and deserve a "Yes" vote.
The first one asks voters to eliminate the residency requirement for hiring city employees. When Huntington had 75,000 plus residents, this rule worked well, but with our significant population decline and the city's goal of recruiting the best employees, this is no longer practical.
The second amendment change removes the requirement for the director of public works to be a licensed public engineer. These credentials are no longer essential for the type of work to be performed.
The third item eliminates a central garage and motor pool for all city vehicles. This hasn't been workable in recent years, if ever.
There is one state Constitutional Amendment on the ballot that I believe deserves a "No" vote.
This would remove the two-term limit from the office of sheriff. In many West Virginia counties, the sheriff has an extreme amount of power from law enforcement and financial oversight. Too much power concentrated for too long in a single individual can be dangerous.
We Americans are fortunate. We have the privilege of voting for the people who represent us as well as the issues affecting us. Whether you agree or disagree with my thoughts here is not the primary issue. What really matters is that you vote not only in the presidential election but also on state and local matters.
Diane W. Mufson is a licensed psychologist. She is a former citizen member of The Herald-Dispatch editorial board and a regular contributor to The Herald-Dispatch editorial page. Her email is firstname.lastname@example.com.
The Herald-Dispatch welcomes your comments on this article, but please be civil. Avoid profanity, obscenity, personal attacks, accusations of criminal activity, name-calling or insults to the other posters. Herald-dispatch.com does not control or monitor comments as they are posted, but if you find a comment offensive or uncivil, hover your mouse over the comment and click the X that appears in the upper right of the comment. If you do not want your comment to post to your personal Facebook page, uncheck the box below the comment.


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Teens will love the bedroom makeover of The Beaches lead singer, Jordan Miller, which includes a cosy lounge area, luxurious bed and envy-inducing walk-in closet. See how smoky purple walls, budget finds, imaginative DIY projects and layered linens create an inspiring space for a musician.
Bed frame, mattress, duvet, bedding, velvet pillows, throws, long mirror, footstools, sofa, cowhide rug, faux-sheepskins, black shelving unit, curtains, curtain rods, hangers, wall shelves, light strip in armoire, Ikea; navy, dark pink pillow, Tonic Living; purple runner rug, eCarpet gallery; walls and ceiling paint, Beauti-Tone Designer Series (matte finish) in Victorian Violet A42-2-1305-4 and Beauti-Tone Designer Series (semi-gloss finish) in Milk Glass WB013-0, Home Hardware; small baskets in dresser, Bacon Basketware Ltd; small stool, framed mirror, damask pillows, baskets, HomeSense.
Executive Producer
Lynda Reeves
Director Online TV Production
Sheri Graham Delagran
Director of Photography
Jason Stickley
Segment Producer
Ryan Louis
Patrick Malone
Erin Gulas
Digital Director
Michael Zimmermann
Online Designer
Julie Whyte
Copyright 2014


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Ten Short Stories is a student edition that introduces some of Roald Dahl's best writing for adults.
The ten stories in this book may depict human nature at its darkest, but they are also brilliantly funny and completely unforgettable with unexpected endings.
With an introduction by Series Editors Ronald Carter and John McRae. Penguin Student Editions have been specifically designed for readers who are studying a text in detail. They include a helpful introduction and explanatory notes, character sketches, a text summary, a chronology, language notes, a selection of questions and topics for discussion and analysis, as well as suggestions for further reading.
Availability: Worldwide
Product ID: 9780140817799
Publisher: Penguin Student Edition
Format: Paperback
Illustrations: Black and White
Orders to the UK will be charged a fixed shipping fee per order of £3.95. Orders to other countries are charged at the following rates (prices are per product ordered):


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Beautiful brother and sister play with a beach ball outdoors
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Monthly Archives: April 2012
Davis Defendants and District of Columbia Contend Appeal Is Appropriate Under Collateral Order Doctrine
Both the Davis defendants and the District of Columbia today filed oppositions to the motion to dismiss their appeals filed by 3M earlier this month. As you might expect, both argue that the appeal is appropriate under the collateral order doctrine. The Davis defendants first directly contest 3M's position that the decision could be reviewed after the case was over. Pointing to numerous decisions holding that anti-SLAPP statutes provide immunity from suit from meritless suits, they argue that 3M's position, if accepted, would force defendants to shoulder the burden of meritless lawsuits through discovery and, perhaps, trial – which is exactly … [ CONTINUE READING
Maddow and NBC Move to Dismiss Second Dean Suit
Rachel Maddow and related NBC defendants today moved to dismiss the duplicative federal court suit filed by Dean and others. This second anti-SLAPP motion, necessitated because Dean is forum shopping in federal court instead of litigating his pending case in Superior Court, makes many of the arguments previously made by the defendants in the Superior Court action. Because the case is now pending in federal court, however, and in light of the opinion in 3M v. Boulter, the defendants argue that the anti-SLAPP statute clearly applies in federal court. They quote from Judge Leon's "Statement of Reasons" in Sherrod v. … [ CONTINUE READING
3M Moves to Dismiss Davis Appeal of Denial of Anti-SLAPP Motion to DC Circuit
Today, 3M moved to dismiss the appeal filed by the Davis defendants. In its motion, 3M argues that the appeal of the district court's opinion and order, denying the anti-SLAPP motion filed by the Davis defendants, must be dismissed because: (a) the district court's order was not a final order within meaning of § 1291; (b) the district court's order is not the type of § 1292 order from which an interlocutory appeal can be taken; (c) the Davis defendants did not obtain permission from the district court to certify the order for appeal; and (d) the order does not … [ CONTINUE READING
3M Also Opposes Consolidation With Sherrod v. Breitbart Appeal
Today, 3M filed its opposition to the motion to consolidate filed by the Davis defendants in the 3M v. Boulter appeal. Yesterday, of course, Ms. Sherrod filed her opposition to that same motion, which sought to consolidate 3M v. Boulter with Sherrod v. Breitbart. Like the Sherrod opposition, 3M's opposition argues that the two cases are not sufficiently similar to warrant consolidation. It also emphasizes, as did Ms. Sherrod's opposition, that the 3M appeal involves the singular Erie issue, while the Sherrod appeal involves Erie, timeliness and retroactivity, so that the Sherrod appeal could be resolved on grounds that are inapplicable (and … [ CONTINUE READING
Sherrod Opposing Consolidation With Davis in DC Circuit
Ms. Sherrod today strenuously objected to the Davis defendants motion to consolidate their appeal in 3M v. Boulter with Sherrod v. Breitbart. According to Ms. Sherrod, appeals are generally consolidated if they arise from the same proceeding or district court judgment/order. While acknowledging that the DC Circuit Handbook provides that cases may be consolidated if they involve "similar or related issues," she argues that this requires the issues to "overlap" or, at a minimum, for common issues to "predominate." Pivoting off this point, she argues that consolidation is inappropriate because the two appeals "arise from different judges and different orders, and [] … [ CONTINUE READING


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Photo credit: Lee Hershfield
Children of Immigrants & Bullying at School
Lorella Praeli was an academic star in high school, was outgoing in her classes and brought home shining grades. Her mother had no idea that she was being cyber bullied.
As a child, Praeli was injured in a car accident in her native Peru when she was just 2. Forced to undergo an above-the-knee amputation, she wears a prosthetic right leg. During high school, other students called her names because she was Hispanic and because of her leg.
"They would create false online profiles using my name and harass me online," Praeli recalls. "They'd call me a border-hopper."
Like many immigrant children, Praeli kept the bullying to herself.
"It's a combination of being embarrassed and worried. There's not as much awareness about bullying in Latin America as there is in the Unites States," Praeli says. "I didn't want to tell my mother about being cyber bullied because she was already overprotective as it was."
Before long, Praeli learned about the Anti-Defamation League (ADL), the world's biggest organization focused on combatting anti-Semitism, raising Holocaust awareness with advocacy and programs that counteract hatred. She began to work with ADL to help educate her classmates about the ways that words can really hurt.
Praeli is just one of millions of Hispanic students who have been bullied in school. The National Center for Education Statistics reported that 27.6 percent of Hispanic students have reported being bullied, says Claudia Rodriguez, assistant project director of ADL's Florida Region.
"But students don't report bullying for many reasons. They may fear the consequences of telling on someone, or they may feel that adults don't care," she says. "They may think that telling their parents will burden them."
Praeli agrees, saying that many Hispanic children won't tell their parents that they are bullied because of role reversal.
"Children can take on the parental role in some ways because their parents lack English skills," she says. "Children know that life is hard for their parents. They want to make things easier on them, and not add to their stress. Immigrant children often try to handle the bullying on their own."
Know the Warning Signs of Bullying
Rodriguez teaches parents and teachers the signs that indicate that their children and students are being bullied. A child may begin skipping school, complain that he or she is "sick" every day, or may close their laptop abruptly when the parent walks into the room.
A child who is suddenly easily angered, begins to snap at their parents, or become uncharacteristically disrespectful, could also be dealing with bullying.
"Talk to your children and ask them about their day," Rodriguez advises. "Really listen to them."
ADL's anti-bias and anti-bullying programs give parents information, both in English and Spanish, about identifying the signs of bullying and how to help their children report bullying when they see it. In addition, ADL provides numerous tools and programs to combat bullying in the community.
ADL's No Place for Hate® Initiative supports schools, communities and organizations in efforts to create safe, respectful and inclusive environments for all. Through trainings and workshops, the campaign empowers schools to promote respect for individual and group differences while challenging prejudice and bigotry.
ADL's trainings not only build awareness, but offer tools to help students recognize and handle bullying.
During ADL's "Voices of Bullying" activity, participants read aloud bullying statements. Sometimes the students feel uncomfortable reading the hurtful statements, but the activity builds empathy by having the participants discuss what actual bullying victims endure. After the activity, the students create action plans to come up with strategies to employ when they encounter bullying.
ADL also helps participants learn how to avoid being bystanders.
"Bystanders may think that the bullying isn't their problem, or they may fear ramifications by speaking up, but we are all obligated to speak up," Rodriguez says. "Even one person can make a change."
Following the No Place for Hate® Initiative, participants pledge a "Resolution of Respect" to combat prejudice and make a promise to do what they can to stop it. After going through the program, schools have the opportunity to implement programs based on the trainings. Then ADL evaluates the school's progress, and gives schools the official No Place for Hate® designation.
After a Miramar, Fla., school participated in ADL's CyberALLY™ training, the school created a Facebook page to build awareness of the subject. The school achieved its goal of attracting 500 Facebook fans months early. Today, over 1,000 schools and 82 communities have been designated as No Place for Hate® .
What's more, ADL is working to teach children acceptance at a very early age. ADL's Miller Early Childhood Initiative is designed to prevent the seed of prejudice before it starts to take root.
Launched almost three years ago, the Miller Early Childhood Initiative has a training component in which a facilitator works with a parent and child. The facilitator leads different activities in which the parent and child talk about differences and similarities among people to hone in on the message that everyone is special. The exercise culminates with the parent and child looking at themselves in the mirror.
"At the age of 4, children can already make their first prejudiced statement," Rodriguez says. "Children aren't born with hate and prejudice; they learn this behavior."
As part of a related research study conducted by Barry University, a group of students were shown a photo of a Hispanic boy and asked whether or not they would play with the little boy. Prior to receiving the Miller Childhood Training, 70 percent of the participants affirmed that they would play with the little boy, Following the training, the percentage of participants that said they would play with the little boy climbed to 86 percent. About 27 percent of the group's of participants were Hispanic.
"We have to change the idea that bullying is just a 'kids will be kids' issue, that bullying is just part of growing up, or that children are just kidding," Rodriguez says. "Over time, targets of bullying can feel that they deserve this treatment, and even accept it. This behavior has to be stopped to avoid determinant consequences."
You can obtain a comprehensive tool kit for combating cyber hate and cyber bullying, sign up for trainings and receive info on programs offered by contacting the ADL regional office closest to you. For more information, visit adl.org.


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Hold down Control (PC) or Command (Mac) key + mouseclick to select more than one option
|Avg. Dinner Entrée
|Greater than $25
|$18.01 - $25
|$12.01 - $18
|$7.01 - $12
|Less than $7
Posted by Dave P on 05/05/2005
The staff, and ambiance, were great - the food was fantastic!
Posted by Anonymous on 04/12/2005
The decorations and service were great. The food left much to be desired. We liked one of the appetizers, but felt like it would be easy to replicate at home. One entree was okay, the other was not. I don't know if the chef accidentally put turmeric in twice or thrice but that was all that you could smell or taste. For the prices charged, one wouldn't expect such mistakes.
Posted by Indian Food Lover on 03/13/2005
The chefs, originally at Amma, seem to have lost their touch. Many of the entrees were no better than neighborhood Indian restaurants...or 6th Street! The sauces for dishes like the turkey keema were quite oily. Too expensive for what it is.
Posted by Anonymous on 02/08/2005
Everyone in my party had an excellent time - service was knowledgeable, friendly, and attentive. The food was of a really excellent quality and my only complaint is that it was a bit too spiced (and I love 'heat') - keep the flavors, but take the heat down just a bit on the entrees. The space was pretty but could've been a bit more luxurious and/or lush (but maybe I'm just spoiled by spice market's decor). And this is picky but the menus were just slips of paper - for the price being charged (and justified by the food), the menus should be a bit more thoughtful since they are part of the experience. Ditto for the wine list which was sparse.
Posted by Liberte on 01/20/2005
The menu is similar to Amma (Midtown), but trendier and the cocktails are excellent! We had the tasting menu for $55 and all of it was spectacular. The 7-course menu is well selected and prepared beautifully. Probably the best Indian restaurant in NYC!
Posted by Impressed on 12/07/2004
...make sure you have the mango cheesecake.... unbelievable!
Posted by ssp on 11/12/2004
Went to check out this new highly touted restaurant-- all of our high expectations were met. We liked the atmosphere-- food was fantastic, though in small proportions relative to other indian restaurants in the city. Service was also great. While you may be able to get better (and more) food at some other indian joints in the city, for a new trendy restaurant, this can't be beat. Great Kulfi.


text: Comments by Dan Ring, The Republican - masslive.com tag:profile.masslive.com,2015:dring413/1828151 2012-07-11T01:22:12Z Movable Type Enterprise 4.29-advance Comment on MGM Resorts asks Massachusetts gaming officials for new bidding process tag:www.masslive.com,2015:/politics/index.ssf//2591.21109782 2012-07-11T01:22:12Z 2012-07-11T01:22:12Z springfield1st -- MGM is asking to scrap the first step, which is the general application to prove strong enough finances and ethics to proceed to a second step, which would be bidding for an actual casino resort license. MGM wants dring413 http://www.masslive.com/ring Comment on Speaker of Massachusetts House plans to trump Gov. Deval Patrick's rejection of EBT card restrictions tag:www.masslive.com,2015:/politics/index.ssf//2591.21101533 2012-07-09T23:56:35Z 2012-07-09T23:56:35Z acidbird -- Deval Patrick has submitted the amendment to the state Legislature. He wants to amend the changes that legislators approved in the state budget for the cards. Legislators must vote whether or not to accept that amendment. That's a dring413 http://www.masslive.com/ring Comment on Wording of medical marijuana ballot question approved by Massachusetts judge tag:www.masslive.com,2015:/politics/index.ssf//2591.21064194 2012-07-03T17:22:44Z 2012-07-03T17:22:44Z Flutie_Flambert_990 -- Those are interesting quotes, even if they are out of context. Thanks for posting. dring413 http://www.masslive.com/ring Comment on Peter, Paul Picknelly in negotiations to develop casinos in Springfield tag:www.masslive.com,2015:/politics/index.ssf//2591.20967292 2012-06-20T20:25:26Z 2012-06-20T20:25:26Z concretepillow -- One of the companies is OPAL, a real estate development company owned by Peter Picknelly. I could not learn the name of the other company on the offer for an option on The Republican building. dring413 http://www.masslive.com/ring Comment on Massachusetts Supreme Judicial Court orders change to ballot question on medical marijuana tag:www.masslive.com,2015:/politics/index.ssf//2591.20849316 2012-06-08T19:15:25Z 2012-06-08T19:15:25Z Change is spent -- The state survey found that 68 percent of high school students reported ever having one drink of alcohol, down from 75 percent in 2003. Also, 20 percent of middle school students, or those in grades 6 dring413 http://www.masslive.com/ring Comment on Massachusetts Supreme Judicial Court orders change to ballot question on medical marijuana tag:www.masslive.com,2015:/politics/index.ssf//2591.20848895 2012-06-08T18:41:53Z 2012-06-08T18:41:53Z joedawg, Stopwastingmytaxmoney -- One interesting fact from a state survey of high school students, released today by the Patrick administration, is that 28 percent of such students reported using marijuana in the last 30 days, the same as in 2003. dring413 http://www.masslive.com/ring Comment on UMass students could see tuition and fee hikes of nearly 5 percent tag:www.masslive.com,2015:/news/index.ssf//865.20810060 2012-06-05T15:13:25Z 2012-06-05T15:13:25Z When UMass trustees approve a fee hike more than inflation, the meeting usually does not happen on the Amherst campus and apparently for good reason. A meeting in Amherst would bring out more critics and possible student protests. Meetings for dring413 http://www.masslive.com/ring Comment on Massachusetts Gaming Commission may not approve 3 casinos for state tag:www.masslive.com,2015:/news/index.ssf//865.20747929 2012-05-30T14:19:23Z 2012-05-30T14:19:23Z starpillar -- There is no guarantee for a casino in Western Mass. The law allows up to three casino resorts in different zones around the state including one for anywhere in the four counties of Western Mass. The law gives dring413 http://www.masslive.com/ring Comment on Massachusetts Gov. Deval Patrick to give keynote speech for Iowa Democrats in June tag:www.masslive.com,2015:/politics/index.ssf//2591.20341161 2012-04-28T00:54:06Z 2012-04-28T00:54:06Z 10sne1 -- I see this as an opportunity for Deval Patrick to introduce himself to an audience that will be picking a presidential candidate at caucuses in 2015. If the economy continues to pick up, Barack Obama is re-elected, and dring413 http://www.masslive.com/ring Comment on Massachusetts parole board denies parole to Juan Ortiz in killings of 2 Springfield police officers tag:www.masslive.com,2015:/news/index.ssf//865.20249866 2012-04-22T14:59:55Z 2012-04-22T14:59:55Z breezee -- Juan Ortiz was convicted of two counts of second-degree murder and given concurrent life sentences. A second degree murder conviction in MA has a maximum sentence of life in prison with the chance of parole after 15 years. dring413 http://www.masslive.com/ring Comment on Massachusetts parole board denies parole to Juan Ortiz in killings of 2 Springfield police officers tag:www.masslive.com,2015:/news/index.ssf//865.20241477 2012-04-21T17:12:03Z 2012-04-21T17:12:03Z gingrichisinsane: It could be that Juan Ortiz is receiving a relatively speedy new parole hearing possibly because he kind of fell through the cracks of the system after his last hearing in December 2010. After a lifer on parole killed dring413 http://www.masslive.com/ring Comment on Former Massachusetts Treasurer Shannon O'Brien says voters may not trust presidential hopeful Mitt Romney tag:www.masslive.com,2015:/politics/index.ssf//2591.20217394 2012-04-19T21:08:44Z 2012-04-19T21:08:44Z LouCypher -- Yes, I recall that about Shannon's stance on abortion. The late Tim Russert posed that question during the final debate and Shannon stumbled on that one. Under existing law, a woman needs to be 18 to have an dring413 http://www.masslive.com/ring Comment on Former Massachusetts Treasurer Shannon O'Brien says voters may not trust presidential hopeful Mitt Romney tag:www.masslive.com,2015:/politics/index.ssf//2591.20214066 2012-04-19T18:09:26Z 2012-04-19T18:09:26Z Tigerbangs -- Shannon O'Brien is still the only Democrat who has ever lost an election to Mitt Romney, so, whether anyone agrees or not with her point of view, she does have an interesting perspective on the presidential contest. She dring413 http://www.masslive.com/ring Comment on Ameristar Casinos continues push for destination resort in Springfield tag:www.masslive.com,2015:/news/index.ssf//865.20015614 2012-04-05T13:39:25Z 2012-04-05T13:39:25Z heidilee -- Thanks for that insight. I know the mayor supports a city-wide vote, but it may not become final until the City Council votes, so this issue -- a ward or city-wide vote -- still appears to be undecided. dring413 http://www.masslive.com/ring Comment on Ameristar Casinos continues push for destination resort in Springfield tag:www.masslive.com,2015:/news/index.ssf//865.20006463 2012-04-04T19:58:29Z 2012-04-04T19:58:29Z slick5 -- Thanks for the story idea on polling city councilors in Springfield to see if they would support a city-wide vote on a casino. It might be getting a little ahead of the game to do the story at dring413 http://www.masslive.com/ring Comment on Ameristar Casinos continues push for destination resort in Springfield tag:www.masslive.com,2015:/news/index.ssf//865.19995697 2012-04-04T02:55:02Z 2012-04-04T02:55:02Z slick5 -- As I've reported several times in the past, it seems pretty clear that all of Springfield would vote on any possible casino plan for the city. Springfield Mayor Domenic Sarno has said he will ask the City Council dring413 http://www.masslive.com/ring Comment on Three former probation officials, including Hatfield resident William Burke III, indicted on mail fraud and other charges tag:www.masslive.com,2015:/news/index.ssf//865.19837065 2012-03-23T19:50:56Z 2012-03-23T19:50:56Z These indictments of probation officials alone may not have much of an impact on Beacon Hill. State legislators, reacting to the scandal, last year passed a new law that restricts nepotism and patronage in state government, overhauls hiring in probation dring413 http://www.masslive.com/ring Comment on Federal judge may decide if strip search by Springfield police violated civil rights tag:www.masslive.com,2015:/news/index.ssf//865.19740596 2012-03-17T02:39:58Z 2012-03-17T02:39:58Z roadrunner413 -- As far as I could determine, there was no prior media coverage of this raid and arrests. dring413 http://www.masslive.com/ring Comment on Rep. Cheryl Coakley-Rivera pushes bill to limit the chaining of dogs in Massachusetts tag:www.masslive.com,2015:/news/index.ssf//865.19645113 2012-03-10T20:33:44Z 2012-03-10T20:33:44Z There is a link to the legislation itself in the second paragraph of this story -- Here is the language from the legislation on tying up your dog overnight: (d) No person owning or keeping a dog may leave a dring413 http://www.masslive.com/ring Comment on Massachusetts court: Use of middle finger is free speech but can be real threat tag:www.masslive.com,2015:/news/index.ssf//865.19101032 2012-02-01T16:10:37Z 2012-02-01T16:10:37Z lib03 -- This was actually a closely watched decision around the state and an important test for a relatively new state law that allows civil court orders to stop harassment. The Boston Area Rape Crisis Center, the Victim Rights Law dring413 http://www.masslive.com/ring


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Now that Ed Reed has been fined for a second time this season for what the NFL has determined to be illegal, helmet-to-helmet hits -- though he has avoided suspension -- Ravens coach John Harbaugh emphasizes that more must be done to balance the playing field on both sides.
Reed was fined $55,000 for hitting Victor Cruz of the New York Giants last week on a play that was flagged as a personal foul.
Reed was driving his shoulder into the chest of Cruz, but their helmets also clashed which drew the flag. Apparently, Reed hasn't been suspended because it doesn't appear that he's going for the opponent's head as Cruz dipped to evade contact.
He initially faced a one-game suspension last month for a similar hit on Emmanuel Sanders of the Pittsburgh Steelers because it would've been his third offense in three seasons. That was overturned on appeal and Reed avoided losing one week's salary ($423,000).
Reed will be available to play in Sunday's finale at the Cincinnati Bengals.
"Although the motivation is correct and the idea is right, it's still a work in progress," Harbaugh said Friday. "Like I said before, our guys are doing everything they can. I'm really proud of our guys (with) the way that they've responded to try to play within the rules and respect player safety.
"Sometimes it's easier said than done, but they are doing their best."
Harbaugh said after the Giants game that the NFL needs to review its process of fining players and distinguishing between intentional and unintentional blows to the head.


text:
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The Immanent Word: The Turn to Language in German Philosophy, 1759-1801by Terezakis; Katie
Nonspecific Binding
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Returning books is as easy as possible. As your rental due date approaches, we will email you several courtesy reminders. When you are ready to return, you can print a free UPS shipping label from our website at any time. Then, just return the book to your UPS driver or any staffed UPS location. You can even use the same box we shipped it in!
What version or edition is this?
This is the 1st edition with a publication date of 5/1/2013.
What is included with this book?
- The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any CDs, lab manuals, study guides, etc.
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The Immanent Wordestablishes that the philosophical study of language inaugurated in the 1759 works of Hamann and Lessing marks a paradigm shift in modern philosophy; it analyzes the transformation of that shift in works of Herder, Kant, Fichte, Novalis and Schlegel. It contends that recent studies of early linguistic philosophy obscure the most relevant commission of its thinkers, arguing against the theological appropriation of Hamann by John Milbank; against the "expressive" appropriation of Hamann and Herder by Christina Lafont and Charles Taylor; and against Philippe Lacoue-Labarthe and Jean-Luc Nancy's uncritical championing of Schlegel's ideological position.


text:
Gear Review
Perfect Fall and Spring
This a perfect glove down to roughly 45 degrees or so, the first few miles might be a bit chilly but once you get warmed up they are awesome and they breathe exceptionally well and have an excellent fit. I wear a large in everything and wear a large in these. I know some people like to wear a second glove under their gloves for warmth but I don't think I could fit another glove under these. Would definetely purchase these again for Fall/Spring riding.
View More Details on Gore Bike Wear Mistral Gloves


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Single isomer methylphenidate, selected from the d- and l-threo-enantiomers, has been obtained in purified form, to the extent of less than 2% by weight of a contaminant selected from resolving agent and ritalinic acid. This is achieved by resolution of a mixture of enantiomers using an O, O′-diaroyltartaric acid as resolving agent.
1. A single isomer methylphenidate compound, selected from the group consisting of the d-threo- and l-threo-enantiomers, and pharmaceutically-acceptable salts thereof, wherein said compound is in combination with less than about 2% by weight of a contaminant selected from the group consisting of resolving agents and ritalinic acid.
2. The methylphenidate compound, according to
3. The methylphenidate compound, according to
4. The methylphenidate compound, according to
5. The methylphenidate compound, according to
6. The methylphenidate compound, according to
7. A pharmaceutical composition comprising a single isomer methylphenidate compound, selected from the group consisting of the d-threo-enantiomers, and pharmaceutically-acceptable salts thereof, and a pharmaceutically-acceptable diluent or carrier, wherein said compound is in combination with less than about 2% by weight of a contaminant selected from the group consisting of resolving agents and ritalinic acid.
8. The pharmaceutical composition, according to
9. A method for treating a person having a condition susceptible to treatment with methylphenidate comprising administering to the person an effective amount of a single isomer methylphenidate compound selected from the group consisting of d-threo-methylphenidate, and pharmaceutically-acceptable salts thereof, wherein said methylphenidate compound is in combination with less than about 2% by weight of a contaminant selected from the group consisting of resolving agents and ritalinic acid.
10. The method, according to
11. The method, according to
This application is a continuation of U.S. application Ser. No. 08/788,881, filed Jan. 22, 1997, issued now U.S. Pat. No. 6,242,464, which claims the benefit of provisional U.S. application Serial No. 60/013,779, filed Mar. 21, 1996.
This invention relates to the resolution of threo methylphenidate via crystallisation of diastereomeric salts, and to the especially pure enantiomers thus obtained.
Methylphenidate is a therapeutic agent that is widely used in the treatment of attention-deficient hyperactivity disorder. It is a controlled substance. Methylphenidate was first prepared as a mixture of the erythro and threo racemates. U.S. Pat. No. 2,957,880 discloses studies upon the two racemic mixtures, which revealed that the therapeutic activity resides in the threo diastereomer. It is now considered that it is the d-threo [or (R,R)] enantiomer that has the preferred therapeutic activity. Uses of this enantiomer are disclosed in PCT/GB96/01688, PCT/GB96/01689 and PCT/GB96/01690, the contents of which are incorporated herein by reference.
The resolution of threo methylphenidate can be achieved using the expensive resolving agent 1,1′-binaphthyl-2,2′-diyl hydrogen phosphate, a process first reported by Patrick et al (The Journal of Pharmacology and Experimental Therapeutics, 241:152-158 (1987)), and subsequently used by other workers in the field (e.g. Aoyama et al, Journal of Chromatography, 494:420 (1989)). This is perceived to be a more efficient procedure than the method disclosed in U.S. Pat. No. 2,957,880, wherein the corresponding amide of erythro methylphenidate (i.e. R-CONR2 rather than R-CON2Me) is resolved with tartaric acid prior to amide hydrolysis and equilibration at the benzylic centre, followed by esterification of the resultant threo-acid.
This invention is based upon the discovery that racemic threo methylphenidate can be resolved using inexpensive carboxylic acids, specifically O,O′-diaroyltartaric acids, with surprising efficiency. In one embodiment of the present invention, either D- or L-O,O-di-toluoyltartaric acid forms diastereomeric salts with threo-methylphenidate, and these salts are very readily separated.
An important consequence of this discovery is that the desired enantiomer is obtained in greater chemical purity than by any prior method. Thus, while the process of Patrick et al may give the desired product contaminated with resolving agent, this contaminant can only be removed by repeated extractions that cause hydrolysis of the ester, leaving ritalinic acid as a contaminant.
Needless to say, a product intended for administration to humans should be as pure as possible. Surprisingly, the process of this invention gives the desired enantiomer in very high chemical and enantiomeric purity. In particular, the product is substantially free of resolving agent and/or ritalinic acid (and/or the opposite enantiomer). This purity can be at least 98%, preferably at least 99%, more preferably at least 99.5%, and most preferably at least 99.9%. The product may be in free base form or as a pharmaceutically-acceptable salt, e.g. the hydrochloride.
The process of this invention may be carried out under conditions that are generally known to those skilled in the art of classical salt resolution procedures.
For example, a mixture of threo-methylphenidate and 1 molar equivalent of D-O,O-ditoluoyltartaric acid in an inert organic solvent is heated and then allowed to cool; the resultant precipitate is filtered, washed with an appropriate solvent and dried to afford directly a salt enriched in at least 97% ee d-threo-methylphenidate, i.e containing less than 1.5% of the opposite enantiomer. Enrichment to higher ee, e.g. at least 99%, can be simply achieved, by reslurrying in fresh solvent and filtering. This is a great improvement on the literature method using 1,1′-binaphthyl-2,2′-diyl hydrogen phosphate, described by Patrick et al, supra, in which the first crystallisation gave a salt corresponding to 85-90% ee material, and further recrystallisation of this material was necessary to raise the ee to 95-97%. The latter level of optical purity is achieved in the present invention in one crystallisation, with an overall higher yield. The method of this invention is therefore more efficient and more economical than the method described by Patrick et al.
Methylphenidate may initially be obtained as a salt of the resolving agent. This may be converted directly to the hydrochloride salt, or any other pharmaceutically-acceptable salt, by a salt exchange procedure. It may be preferable to release the free base, by salt cracking. If desired, the free base can then be converted to a salt form. All these procedures are known to those skilled in the art.
Further advantages of the present invention are as follows:
(i) Salt cracking at pH 9-10 is by addition of aqueous sodium hydroxide, whereas dilute aqueous sodium carbonate is needed for salts of the more base-labile 1,1′-binaphthyl-2,2′diyl hydrogen phosphate; this renders the novel process more volume efficient.
(ii) Lower volume of aqueous medium in (i) means fewer extractions into organic solvent (TBME rather than diethyl ether) to isolate methylphenidate free base.
(iii) Chemical robustness of DTTA allows for clean and efficient recovery.
Either isomer of methylphenidate can be easily obtained by this procedure, e.g. by simply using the D- or L-isomer of the diaroyl tartaric acid derivative as required.
Single isomer methylphenidate according to this invention, especially pure d-threo-methylphenidate, can be used in therapy for the same purposes as the racemate, e.g. in the treatment of ADHD or narcolepsy. The compound can be formulated with any suitable carrier, in any suitable dosage, as will be apparent to one of ordinary skill in the art. Reference in this context may be made to any of the three PCT Applications identified above.
The following Example illustrates the invention.
Ditoluoyl-D-tartaric acid (5.033 g, 12.4 mmol) was suspended in a solution of 2% methanol in acetone (10 ml), and a solution of threo-methylphenidate (2.9 g, 12.4 mmol) in the same solvent (10 ml) was added. The solution was gently warmed to reflux whereupon all the reagents dissolved. The solution was immediately cooled and crystals began to form. The solution was allowed to stand at 4� C. for 17 hours and was then filtered. The crystals were washed with acetone (3�15 ml) and dried in vacuo to yield the ditoluoyl-D-tartrate salt of d-threo methylphenidate (3.516 g, 44.3% by weight; corresponding to 97% ee d-threo methylphenidate, as determined by chiral HPLC after salt cracking). The mother liquors were dried in vacuo to yield the ditoluoyl-D-tartrate salt of l-threo-methylphenidate as a solid, dry form (4.508 g, 50.5% yield, 88% ee).
The ditoluoyl-D-tartrate salt of d-threo-methylphenidate (3.486 g), obtained as described above, was suspended in 2% methanol in acetone, and warmed to c. 40� C. and cooled. This did not dissolve the solid which was stirred at room temperature for 24 hours. The suspension was filtered, the solid washed with acetone (10 ml) and dried in vacua, to yield diastereomerically pure material (3.209 g, 92% recovery, corresponding to >99% ee d-threo-methylphenidate).
Repeating this protocol using isopropanol: methanol as the solvent, gave the same salt, on initial crystallisation, enriched in at least 98%. Reslurrying increased this.
For the purposes of comparison, USP grade dl-threo-methylphenidate hydrochloride (3.36 g) was dissolved in an aqueous solution of sodium carbonate (45 ml, 2% w/v), and the clear solution was extracted with diethyl ether (3�50 ml). The combined ethereal layers were dried (MgSO4), filtered, and evaporated to dryness. The resulting pale yellow oil together with (R)-(−)-1,1′-binaphthyl-2,2′diyl hydrogen phosphate (3.36 g) were dissolved in a hot mixture of acetone/methanol (95:5). The solution was gently stirred and cooled to 5� C. and maintained for 12 hours. The resulting white crystals (2.98 g) were isolated by filtration and recrystallised from acetone/methanol (98:2). This product was then treated with a 2% aqueous solution of sodium carbonate and extracted with diethyl ether (4�50 ml). The combined ethereal layers were dried (MgSO4) and filtered. An excess saturated solution of hydrogen chloride in ether was then added and the resulting hydrochloride salt was filtered, rinsed with ether, and recrystallised from methanol/ether. The resulting white crystalline product was analyzed by HPLC and proton NMR:
% w/w l-threo: 3.7%
e.e.: 92.6%
ritalinic acid: trace amount but not quantified by HPLC or NMR
resolving agent:approximately 4% by NMR
It should be understood that the examples and embodiments described herein are for illustrative purposes only and that various publications or changes in light thereof will be suggested to persons skilled in the art to be included within the spirit and purview of this application and the scope of the appended claims.
Patent Citations
Non-Patent Citations
Referenced by
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NM Senators pass two Senate Joint Memorials aimed to improve state Behavioral Healthcare
By Eduardo Rodriguez
Las Cruces, NM – Joint Memorials requesting a set of studies to help improve the lives of the state's population affected by mental illness cleared the Senate and will be considered in the house. As KRWG's Eduardo Rodriguez reports, the sponsor is optimistic the set of proposals will bring needed improvements but an activist doubts their approval will bring much change.


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1. Prepare materials:
Potatoes: 200 gr.
Dextrose: 20 gr.
Agar powder: 20 gr.
Water: 1 liter.
Cotton (gauze)
4. Place potatoes in one liter of water. Simmer for 15 - 20 minutes.
5. Remove potatoes & keep the broth as clear as possible. Add water to broth to reach one liter of liquid PDA
6. Bring water to stove. Add dextrose followed by agar. Slowly stir continuously with regular speed until completely dissolved.
7. Pour liquid PDA in bottle until you reach 5 - 10 mm high.
8. Plug bottle with cotton.
9. Place bottles in autoclave at 121oC for 20 - 30 minutes to ensure complete sterilization. Let cool down to around 37oC.
10. Place bottles in slanted position as to increase surface area of the medium. PDA should come close to the neck but must not touch the cotton plug.
After PDA medium is settled in bottle, transfer all bottles to clean shelf in the clean room.
11. Check for contamination (contamination can be seen when dark spots or lines occur).
1. Prepare materials:
2. Select a strong mushroom for culture.
12. Close bottle immediately near the flame with cotton plug
Note: the bottom of the bottle should always be lower than the mouth of the bottle and the mouth of the bottle should remain near the flame at all times.
13. Label bottles and indicate: Date, type of mushroom, mother spawn #.
Because of the extremely delicate nature of tissue culture, it is highly recommended that tissue culture be done in only a few bottles of PDA since there is high risk of contamination. Then, several bottles of PDA can be prepared from the extremely pure mycelium.
9. With the needle, cut a small piece (5 mm x 5 mm) of mycelium on PDA Make sure that the PDA not contaminated.
10. Flame around the mouth of the new PDA bottle. Using other fingers, remove cotton plug of PDA bottle in front of flame to secure against contamination.
10. Flame around the mouth of the new PDA bottle. Using other fingers, remove cotton plug of PDA bottle in front of flame to secure against contamination.
11. Insert the needle in the bottle and inoculate by placing small piece of PDA mycelium on the middle of the PDA's surface. Make sure the mycelium PDA does not touch anything before entering the PDA bottle.
12. Close bottle immediately near the flame with cotton plug
Note: the bottom of the bottle should always be lower than the mouth of the bottle and the mouth of the bottle should remain near the flame at all times.
13. Label bottles and indicate: Date, type of mushroom, mother spawn #.
15. Keep PDA bottles with mycelium on clean shelf.
Check infection by other fungi in the bottle everyday. Also check growth rate.
16. After mycelium covers whole PDA medium, keep mature mycelium in cool place or in the refrigerator in the vegetables section.
1. Prepare materials:
Note: Various types of grains can be used: Sorghum, millet, wheat
Grains must:
2. Soak sorghum for one night; 2 liters of water per 1 kg of grain.
Wash and strain sorghum seeds to remove all water.
8. Transfer all prepared bottles to the sterilization chamber.
Close chamber. Fire-up burner or stove to heat chamber. Make sure to release all air from the chamber before starting. Keep pressure in the chamber at 15 lb./sq.inch. or 121o Celsius for 30 minutes for small chambers and 45 minutes for medium chambers.
Let bottles cool down.
9. Transfer bottles to a clean and cool place.
10. Bottles must be cleaned and well prepared. Prepare the well verified PDA bottles
12. Transfer PDA, sorghum seed bottles, paper and rubber bands in laminar flow chamber. Light UV lamp for 10 - 15 minutes before starting. Place needle in alcohol.
14. After the needle cooled down to normal state, use needle to cut small square (5mm x 5mm) of PDA with mycelium (white color).
16. Using other hand flame around the mouth and shoulder of the sorghum seed bottle.
Using other fingers, open spawn bottle near flame to avoid contamination.
17. Insert needle and inoculate sorghum seeds with PDA mycelium by placing small square piece in the middle of the bottle. Make sure the PDA mycelium does not touch anything before entering the sorghum seeds bottle.
Note: The mouth of the bottle should be near the flame. The mouth should remain higher than the bottom part at all times. Do not touch mouth of bottle with piece of PDA.
20. Label inoculated sorghum bottles writing: Date, Spawn no., ref., and inoculation time.
Note: It takes about 10 - 15 days to get full-grown sorghum grain mycelium, depending on the species.
21. Keep mature sorghum seeds in a cool place or in the vegetable compartment of the refrigerator. Check for infection regularly.
22. Remove contaminated bottles.
23. Observe and collect data. Take notes to draw conclusions.
Note: A loss of about 3% is to be expected.


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'Pink paradise"
As the guests of honor entered the Sanford Elks Lodge Tuesday night, they were welcomed with the gift of pink leis and the heartfelt greeting of "aloha!"
The warm reception continued for the approximately 30-plus breast cancer survivors in attendance at the Central Carolina Hospital Auxiliary's "Pamper Yourself Night Out." The second annual gathering — which had a "pink paradise" theme — brought breast cancer survivors together for a night of fellowship and special activities.
"Aloha" translates to "hello" and "goodbye" in English, explained CCH Auxiliary President June Gunter, but in the Hawaiian language, it means affection, peace, compassion and mercy.
"My favorite is compassion; each of you has compassion for each other," Gunter told those assembled. "You not only receive compassion and support from your family [and] friends, but each other. You are a family, sisters."
Gunter added that the Auxiliary is available as a means of support.
"We want you to know that when you have a down day and you feel a sudden burst of strength and smile, you are receiving compassion from us and other individuals who are thinking of you and supporting you," she said. "Some you may know and others you may not know."
Area businesses and individuals treated the survivors to back massages, makeup sessions, nail polishing, hand treatments and other services. Some in attendance went home with door prizes, and at the end of the evening, CCH Breast Health Navigator Gwyn Sandlin gave each lady a Susan G. Komen T-shirt, and attendees also received a long-stem pink carnation.
With the venue awash in pink, including flowers, ribbons and even desserts, attendee Mary John Coggins said, "It was really wonderful."
"The place was an absolute fairyland," Coggins said. "It was a special, special night."`
A five-year survivor, Coggins emphasized the importance of exercise, a strong support system of faith, friends and family, and a positive attitude.
"You've got to have a sense of humor," Coggins said. "If you can't laugh, you're not going to make it."
According to The American Cancer Society, breast cancer is the most common cancer among women in the United States, other than skin cancer, and the second-leading cause of cancer death in women after lung cancer. October is Breast Cancer Awareness Month, and on Oct. 18, National Mammogram Day, CCH staff will wear pink.
To schedule a mammogram, call (919) 774-2157.


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Fort Wayne hockey player Griffen Fisher, 12, is part of an Indianapolis hockey team which will leave Thursday to compete in the 55th Quebec Pee Wee International Tournament. Fisher, a seventh grader at Carroll Middle School, is part of the Indianapolis Junior Ice. It's been 23 years since an Indiana team was invited to play in the 10-day Quebec tournament.
The Ice won the Central State Hockey League title last weekend as Fisher scored the tying goal late in the championship game to force overtime. He has scored 28 goals and 48 points in 51 games this season.
ILSAA state tourney coming to Fort Wayne
Concordia Lutheran High School will host the 2014 Indiana Lutheran Schools Athletic Association State Basketball Tournament on Feb. 28 through March 2. This will be the first time the tourney has been held in northeast Indiana.
A total of 20 to 24 boys and girls squads will compete in the tourney for students in grades 6 through 8. The top boys and girls teams will be invited to the annual Lutheran National Tournament at Valparaiso in March.
A guest speaker will address the players and families during a special program at Concordia High School after Saturday's final games. After the program, the teams will be recognized during a Fort Wayne Mad Ants game.
The tournament will make use of both of Concordia High School's two gymnasiums, as well as the gym at nearby Holy Cross Lutheran School, keeping the competition in one area of the city.
University forum features former NFL player
Dr. Jason Carthen, a former professional football player with the New England Patriots and international speaker in the areas of leadership, business and identifying your purpose in life, will speak at Indiana Tech as part of the University Forum speaker series. The presentation entitled "Overcoming Obstacles to Achieve Greatness" starts at 7 p.m. Feb. 13 in Magee-O'Connor Theater (in Andorfer Commons). The event is free and open to the public.


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Marina del Rey, Calif --December 2, 1998-- Quarterdeck Corporation (OTC:QDEK) announced today that it plans to hold a special meeting of its stockholders in February 1999 for the purpose of voting on the previously announced cash merger between Quarterdeck and Symantec Corporation (Nasdaq: SYMC). As previously announced, on November 16, 1998, a wholly-owned subsidiary of Symantec completed a tender offer for Quarterdeck's outstanding shares of Common Stock, and now owns more than 58 million shares, representing over 60% of Quarterdeck's outstanding Common Stock. As a result of the planned merger, Quarterdeck would become a wholly-owned subsidiary of Symantec, and the holders of the Quarterdeck Common Stock not previously acquired in the tender offer would be entitled to receive the tender offer price of $0.52 per share. The merger would be consummated shortly after the February stockholders' meeting.
About Quarterdeck
Quarterdeck Corporation is a global leader in the development and marketing of PC helpware. Quarterdeck's current product line, which addresses storage management, system conflict resolution, virus protection, system updating, and enhanced access to networked information and communications resources, is marketed to both end-users and businesses via retail distribution, corporate resellers and OEMs, direct marketing channels, and the Internet. Incorporated in 1982, Quarterdeck's worldwide headquarters are in Marina del Rey, California, with its European operations based in Dublin, Ireland. Further information may be obtained by calling 800-354-3222 toll-free or 573-443-3282, by accessing Quarterdeck's Web site at http://www.quarterdeck.com, or by sending e-mail requests to email@example.com.
About Symantec
Symantec is the world leader in utility software for business and personal computing. Symantec products and solutions help make users productive and keep their computers safe and reliable anywhere and anytime. Symantec offers a broad range of solutions and is acclaimed as a leader in both customer satisfaction and product brand recognition. Symantec is traded on Nasdaq under the symbol SYMC. More information on the company and its products can be obtained at www.symantec.com.
NOTE TO EDITORS: If you would like additional information on Symantec Corporation and its products, view the Symantec Press Center at www.symantec.com/PressCenter/ on Symantec's Website.


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Beaded Butterflies Craft
by Cindy Hopper
Spring is near and these beaded butterflies are a perfect craft for the season.
Chinese New Year: Year of the Horse Mask!
This Chinese New Year, it's Year of the Horse and we created an exciting paper mache horse mask.
Chinese New Year Craft: Year of the Horse Printable
It's tradition. Every year about this time I make a Chinese New Year (this year, it's January 31st) craft printable. This year we are back into making paper animals. It's the Year of the Horse, and this craft is super easy.
DIY Snowman Soap!
Make your own Snowman Soap. Our tutorial teaches you how to make this messy, but super fun craft. Snowmen Soap make great handmade gifts.
DIY Paperweights are Easy-to-Make Holiday Gifts
by Cindy Hopper
These colorful paperweights make the perfect handmade gift that a child can make.
Day of the Dead DIY T-shirt for Kids Tutorial!
Dia de los Muertos, or Day of the Dead, is a three-day observation starting on October 31. Its purpose is to honor those who have passed away. Calaveras (or artful skulls) are a common symbol of the holiday. Learn to make Day of the Dead t-shirts with your kids with our free skull stencil and tutorial.


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Antimicrobial Drugs
10. List the antibiotic with
the fewest side effects.
All penicillins contain a B-lactam ring.
Natural Penicillins
Natural penicillins (Penicillin G, Penicillin V) produced by Penicillium are effective against gram-positive cocci and spirochetes.
Natural penicillins have a narrow spectrum activity and are susceptible to penicillinases (or B-lactimases) - bacterial enzymes that destroy natural penicillins.
Retention of Penicillin G
The Effect of Penicillinase
Semisynthetic Penicillins
Semisynthetic penicillins are made in the laboratory by adding different side chains onto the B-lactam ring after it is synthesized by a fungus.
Semisynthetic penicillins (oxacillin, ampicillin, amoxicillin, aztreonam, imipenem) are resistant to penicillinases and have a broader spectrum of activity than natural penicillins.
Pecillinase-Resistant Penicillins
The first penicillinase-resistant semisynthetic penicillin was methicillin. We've got so much methicillin resistance that methicillin use has been discontinued in the U.S.
Oxacillin and nafcillin are replacements for methicillin.
Extended-Spectrum Penicillins
Ampicillin and amoxicillin are aminopenicillins, which are effective against both gram-positive bacteria and many gram-negative bacteria, but aren't penicillinase resistant.
The carboxypenicillins carbenicillin and ticarcillin were developed to fight aminopenicillin-resistant organisms and have better activity against gram-negative bacteria, including Pseudomonas aeruginosa.
Ureidopenicillins like mezlocillin and azlocillin are more recently developed extended spectrum penicillins.
Penicillins plus B-lactam Inhibitors
Potassium clavulanate is an inhibitor of penicillinase that can be combined with broad spectrum penicillins.
Augmentin is amoxicillin plus potassium clavulanate.
Carbapenems are broad-spectrum B-lactam antibiotics that inhibit cell wall synthesis.
Primaxin is a combination of imipenem and cilastin (which inhibits degradation in the kidneys) and is active against 98% of all organisms isolated from hospital patients.
Monobactams are made resistant to penicillinase by using only a single ring rather than the B-lactam double ring.
Aztreonam affects only certain gram-negative bacteria, including pseudomonads and E. coli.
Cephalosporins inhibit cell wall synthesis like penicillins and have more activity against gram-negative organisms.
They are used against penicillin resistant strains but are susceptible to a different class of B-lactamases and also are contraindicated in people with penicillin allergy.
First generation cephalosporins include cephalothin, and cephalexin. Later generations of cephalosporins have greater activity against gram-negative organisms but sometimes don't work as well against gram-positive organisms (those beta-lactamases, damn it!). The goal is to be able to treat S. aureus, S. pneumoniae, Enterococcus, and Psuedomonas, and offer a reasonable dosing regimen (oral vs. parenteral, longer times between doses).
The third generation cephalosporins cefpodoxime (Vantin), cefdinir (Omnicef) and cefixime (Suprax) have been approved for oral administration. Third generation cephalosporins that require parenteral administration include cefotaxime (Claforan) and ceftriaxione (Rocephin).
Fourth generation? You bet - cefepime (Maxipime) - good against gram-positive cocci and Pseudomonas and is resistant to hydrolysis by many expanded spectrum beta-lactamases (ESBLs).
Comparison of Cephalosporin and Penicillin
Polypeptide Antibiotics
Bacitracin inhibits cell wall synthesis primarily in gram-positive bacteria. It is applied topically to treat superficial infections.
Vancomycin inhibits cell wall synthesis and may be used to kill penicillinase-producing staphylococci.
Isoniazid (INH) inhibits mycolic acid synthesis in mycobacteria and is used to treat tuberculosis. INH is administered with rifampin or ethambutol to avoid resistance.
The antimetabolite ethambutol is only effective against mycobacteria. Because it is weak it is used with other antitubercular drugs.