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|168 posts found
Originally posted by Tayah
I don't think DAoC belongs in the same category. Lineage yes, DAoC not so much. It's not that DAoC was bad, but it was kind of the first game where pvp was starting to go themepark. Even though it had a couple sandboxy features the contrived pre-defined only 3 faction thing is a step in the wrong direction with regards to the discussion. They started removing freedom and defining content.
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Novice Member
Joined: 1/06/07
Hype (noun)
Originally posted by Gdemami
Really? C'mon now, think this one through...
MMO = Massively Multiplayer Online
"Censorship is never over for those who have experienced it. It is a brand on the imagination that affects the individual who has suffered it, forever." - Noam Chomsky
Originally posted by orbitxo
Except none of those are WoW clones. They are themepark twists. They might have been going for the WoW themepark success story, but they're essentially all EQ children trying to solve the same problem WoW did only with very marginal success. WoW may own the themepark market but it doesn't own the themepark definition.
And please people let's not be ignorant and put TESO and NWO in that lineage yet because they haven't even released. We have no idea how the games will play. There is so much wrong thinking in going with the "if it's not a sandbox it must be a wow-clone mentality". Just because something is a themepark doesn't mean it's a wow-clone. TERA and RaiderZ play and feel nothing like WoW and have a much more hybrid approach to their design than WoW or RIFT do.
Apprentice Member
Joined: 11/21/11
I'm sorry but rift, swtor and lotro are massive wow clones. Aoc not at launch,but it is now.
The others differ a bit and I wouldn't call them clones.
Novice Member
Joined: 4/11/06
Great way of putting it, Bill. It's definitely been the "systems" that have kept me playing EQ2, LotRO, and SWG for so long. Developers don't seem to think systems are important, or they add them much later after most have already moved on.
Hard Core Member
Joined: 9/27/12
Great article Bill, I agree wholeheartedly.
The sentiments expressed within are pretty much a dead ringer for the way I've felt for quite some time in regards to what needs to be done to get this industry back to the prosperous state it was once in. The game systems themselves are an exceptionally big deal, and I'd personally love to see the level of complexity that existed a decade ago restablished in the modern day titles that are being released.
Well put chief, a good read.
Originally posted by Zekiah
Yeah, it's boggling that you or another would have to explain this. Does Gdemami really not get why MMO require some form of retention? It's this sort of silliness along with all the cardboard wow-clone responses that distract.
The problems Bill touches on are real. If the genre is going to mature in a healthy way it needs to deal with them.
The barrier for entry, and then retention or return to the game is real and no amount of content delivery is going to solve that. Can a developer pump out content and patches faster than Trion has done over the last couple of years? Even then they've only really put out one major update (Ember Isle) and a few smaller updates that kind of add up to Ember Isle. Even though they bust ass they still can't keep up with the consumption.
Games need system, but they also need to be systems that matter. We'll see how Trion does with housing, but even though it looks very nice and robust from a design point will the housing matter to the rest of the game? One reason why EQ2 housing has been so popular is because of it's robust design (ie: free form placement, etc), but even more so because it is heavily integrated with crafting, adventuring, and the broker.
So while we need systems, those systems need to matter.
The payment model as a barrier should be a no brainer but for some reason we're stuck in a rut there. Arena Net might prove that you don't need a sub for content updates (that really remains to be seen over the next year or two) as they're pretty much matching Trion's pace at this point. But what they really need to show is that a B2P game can have robust systems in place. They still need to show that B2P can be relevant.
Novice Member
Joined: 2/14/04
Well, Bill, you're quite late to the party, welcome anyway.
So, the Problem No One's Talking about? Looks like you never read you own forums. We, the regular posters here, are talking about the very same thing since years. You would have no problems to find 1000s of posts telling you so. The Problem No One's Talking about? Smedley from SOE talks about it, Funcom makes noises in the same general direction, Cryptic as well - it wasn't that no one talked about the problem - it was that no one at MMORPG.com wanted to hear anything about it. You guys rather prefer to praise the longevity of these same games ... wasn't it you who rewarded GW2 with a 9 for longevity a few weeks ago? :)
From AoC to GW2 games have launched with great fanfare from this website, have sold millions of boxes - and you are talking about "barrier to entry"? Sorry, but talking about a "barrier to entry" when games with a barrier of $60 for you US guys sell millions of boxes (no matter whether the game has a subscription or not, see SWToR and GW2) should tell you that "barrier to entry" is a complete non-issue. None of the big games of the last 5 years had any problem with it. Marketing removes any barrier to entry for an entertainment product.
Anyway, I welcome that you now put same emphasis on non-content design in MMORPGs - apart from that, thanks, I prefer my subscription games, just like Blizzard and CCP and Trion do.
Advanced Member
Joined: 10/15/04
Originally posted by elocke
This is how Bill writes his colums. Reading here in Forum. Its not something he thought about himself. Im not saying its bad what hes doing either. Keep it up Billyboy.
Novice Member
Joined: 1/06/07
Hype (noun)
Originally posted by Larsa
You, sir, win the internetz.
Worms from can have been removed they have. Put them back in box they cannot.
"Censorship is never over for those who have experienced it. It is a brand on the imagination that affects the individual who has suffered it, forever." - Noam Chomsky
Novice Member
Joined: 3/28/12
I somewhat (with others) enjoy my own system... Roleplay ^.^ Don't need content patches for that :)
"We need men who can dream of things that never were." - John F. Kennedy
Made History
Joined: 7/11/11
Pink, it's like red but not quite.
Erectile Dysfunction? Painful Hemorrhoids? Jock itch? Toenail fungus?
Oh, thank god Bill, for going somewhere else entirely. The title's like an intro for one of those commercials.
Self-pity imprisons us in the walls of our own self-absorption. The whole world shrinks down to the size of our problem, and the more we dwell on it, the smaller we are and the larger the problem seems to grow.
Elite Member
Joined: 9/19/06
Just for the record, I am also pro-features. I thought everyone was.
SWTOR is the greatest mmo ever!
Novice Member
Joined: 1/06/07
Hype (noun)
Originally posted by colddog04
Gamers have been conned into thinking million-dollar cut scenes and one-time content were what we really wanted.
Now, where are all the devs who come here to scan these articles?
Bueller... Bueller... Bueller...
"Censorship is never over for those who have experienced it. It is a brand on the imagination that affects the individual who has suffered it, forever." - Noam Chomsky
Advanced Member
Joined: 7/23/08
I agree with this. Some other points is that MMO companies should be realistic about game design. An MMO doesn't need millions of players to be successful. Most servers by popular standards house 3-4 thousand players at a time. They can make design risks and build a niche core within themselves.
That's the problem I've seen. Many MMO's these days are afraid to jump into uncharted waters (pun, intended). They haven't tried to push theirselves because they belive an MMO requires an extensive sum of money to develop; they are falling into AAA category that doesn't need to be brought.
Played - M59, EQOA, EQ, EQ2, PS, SWG[Favorite], DAoC, UO, RS, MXO, CoH/CoV, TR, FFXI, FoM, WoW, Eve, Rift, SWTOR, TSW.
Novice Member
Joined: 1/06/07
Hype (noun)
Originally posted by Sora2810
But the thing is, those waters have already been charted and sailed successfully. There's plenty of gaming systems out there ready to be reborn and improved upon.
UO, SWG, EQ, DAoC, etc. etc. There are wonderful systems in those titles alone that could easily be improved upon.
It's up to us, the gamers, as to where the future of MMO development takes us. Do we continue paying for subpar games designed around box sales or do we say enough is enough and DEMAND developers to take notice?
"Censorship is never over for those who have experienced it. It is a brand on the imagination that affects the individual who has suffered it, forever." - Noam Chomsky
Elite Member
Joined: 3/22/09
Ever since Smedley talked about sand box elements and then clearly took EQ into that direction, this has been just about the major topic of the day. I've been preaching it for years amongst the many others here chatting over fundamental flaws of themepark games. Some of the largest threads over the last few months have been about the whole themepark/sandbox debate. Simply look over my post history (from a modest post count person) and see the amount of thread content I've posted in on this very subject. I'd say this topic is the fundamental theme (outside if individual game subjects) on these boards and others for months which leads to the massive coverage of upcoming sandbox games and the obvious change in mmo design direction by both indie and AAA companies.
Now let's look at the title of this articile: "The Problem No One's Talking About". Perhaps it should be changed to: "The Problem No One's Talking About: Short Term Memory Loss".
You stay sassy!
Apprentice Member
Joined: 8/23/12
Originally posted by Larsa
Yeah, i was thinking "You guys only figured this out now?" all the way while reading the article .
Regardless, i completly agree Bill. I don't hate story, questing, dungeons, cutscenes, voice-overs, etc at all (expect "personal" stories and voiced pc's). I think they bring good things to the game and give it greater quality. It's developers abusing them and turning them into the main focus of the entire game by 90% that angers. Once you're finished with it, it's over and there's nothing left to achive and play.
More "systems" and "non ending" activities are necessary and fortunatly, it seems quite a few devs are figuring this out. Let's hope mmorpgs like these are coming in the future.
Apprentice Member
Joined: 7/31/06
I consider myself the typical mmo gamer, one that plays for one or two months. In the past, you actually had more GOOD options, CoH, DAoC, EQ, or WoW. Now that all of those games are aged and one is going to be closing, the real options for mmorpg fans are slimmer by the day.
It's actually quite sad. For over ten years I've seen the potential of mmorpgs squandered. I wanted a virtual world that satisfied my different needs. PvP, creation, adventure, social interaction. But in most those areas, every mmo fails in some way.
While I only played any mmo for a month or two at a time (subscribed to CoH 18 months which is only 20% of it's lifetime), I would have played the 'right' mmo for ten years straight. I say 'would have', because I'm getting old and life is getting busier and more complicated, and my desire to stay plugged into a game 20+ hours a week is waning. So in a way, any new great game that finally gets it right is too little, too late. The genre failed me, end of story.
Managing Editor
Joined: 7/28/06
Originally posted by MMOwanderer
I suppose I actually should have said, "The Problem Few Devs Are Acknowledging" but this seemed catchier. :)
In regards to GW2, I still think the game's fantastic... in fact, I love themeparks as much as I long for a good quality take on the Sandbox (Malu and EQNext I'm particularly looking forward to, as well as Darkfall:UW's PVP-oriented take). But a Theme-park can have quality longevity, just the same. For millions, WoW does the trick. I don't know how, but it does.
However, WoW (as the article states) is a fluke. It can afford to take time and sustain itself because of its insane amount of subscribers. As we've seen lately, that model just doesn't work with any other title.


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Ms Powley founded Women in the School of Computing (WISC) at Queen's, an informal support, networking and social group for all women faculty, staff and students. The group has provided outreach and mentorship to young women in the Kingston community through the LEGO robotics program with the hope of educating and inspiring more girls to consider a career in computing.
EQuIP received the Human Rights Initiative Award for Queerientation, an annual event that raises awareness about Queen's queer community among incoming students. Established 15 years ago, Queerientation has resulted in a positive orientation for generations of lesbian, gay, bisexual, transgendered and queer students and has ultimately made Queen's a more welcoming and inclusive place for people of all sexual and gender identities.
Jessica Sinclair accepts the Human Rights Initiative Award from Provost Alan Harrison on behalf of Education on Queer Issues Project.

subset: commoncrawl


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Rick Blaine dislodged a mud-slicked baby stroller from the murky water surrounding Put-in-Bay's downtown harbor Monday.
"Fortunately, we didn't find a baby," joked Blaine, a Circleville resident, as he emerged from his dive.
He was one of 32 divers who participated in the 17th annual DIVE! Put-in-Bay Harbor Clean-Up off DeRivera Park. Each year the event draws divers from as far away as Pennsylvania and Michigan to help pull refuse out of the waterway.


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By Jim GaramoneAmerican Forces Press Service
LANGLEY AIR FORCE BASE, Va., June 9, 2008 Defense Secretary Robert M. Gates said he was pleased with the give-and-take he had with about 400 Air Combat Command airmen at the base theater here today.
"I felt I needed to look them in the eye and tell them why I made the decisions I made," Gates said.
Gates explained why he felt he had to ask for the resignations of Air Force Secretary Michael W. Wynne and Air Force Chief of Staff Gen. T. Michael Moseley following a report delivered to him about nuclear security lapses.
Following a 20-minute speech, the secretary asked local and traveling reporters to leave so he could take questions from the airmen "unvarnished and straight from the shoulder."
In an interview later with reporters traveling with him to Colorado, Gates spoke about the challenges facing the Air Force leadership team he has proposed of Michael B. Donley as Air Force secretary and Gen. Norton A. Schwartz as chief of staff.
Fixing the nuclear stewardship issue is the most important task for the new leadership team, he said. Nuclear deterrence is going to become more critical, not less so, in the future, the secretary said. He said the rising threat of nuclear proliferation is one reason for his conclusion.
The second important task the new Air Force leadership team will face is "figuring out how to get the modernization program back on track," he said.
Air Force tanker procurement is at least 10 years behind where it should be, Gates said. The new team will have to figure out "how to work with the Congress and get this thing done."
There also needs to be a decision by the next administration on the balance between the F-22 fighter and F-35 Joint Strike Fighter and then "just getting on with it," Gates said. "End the debate, make a decision and move on. 'Start getting stuff built' is just so important. The tankers we are flying today are the tankers I rode in as a second lieutenant in 1967."
Gates discussed Navy Adm. Kirkland Donald's report on the Air Force handling of the nuclear mission. "It seems to me that … maybe the most important conclusion in Admiral Donald's report is that authority and responsibility for the nuclear program is split among multiple commands," he said. "There is no unity of command and no one person responsible for setting the standards for evaluation and for maintaining the professionalism, security and so on of the force."
The military must fix the division of responsibility that has prevented any one person being responsible for making sure that standards are kept, he said. "Ultimately, one of the principal root cause of these problems is there is no one person in charge or who has responsibility. I think you can fix that without re-creating the Strategic Air Command." SAC stood down in 1992, and Air Combat Command assumed many of its responsibilities.
The secretary said the airmen at Langley asked him if they would get the money needed to fix the nuclear problems – the money for training, career development for test equipment and so on. "I told them that while the nuclear program had not been a high priority, the amount of money required to make the necessary fixes are relatively modest," and that he was sure he could get the money from within the Air Force or Defense Department.
Langley is home of the 1st Fighter Wing, which has operational F-22s, and Gates said airmen asked him if the real reason for the change in Air Force leadership was because of a disagreement over F-22 procurement. "I told them it was not true, and the issue had been settled for some weeks," he said. "I had made the decision that we would allocate enough money to keep the production line open so the next administration could decide on the balance between F-22s and Joint Strike Fighters. It's a significant procurement decision that ought not be made in the last six or seven months of an administration."
The secretary told reporters he chose Schwartz as the new Chief of Staff because he "brings fresh eyes to these issues. He's very smart, very process-oriented. The changes he has made in Transportation Command have been pretty dramatic.
"It was mobility, jointness, special operations and being very, very smart" that led him to the choice of Schwartz, Gates said.
Related Articles:Gates Cites Air Force's Value in War on Terror


text:
17β-Acyl-4-aza-5α-androst-1-en-3-ones of the formula: ##STR1## wherein R is selected from hydrogen, methyl and ethyl and
R2 is a monovalent radical selected from straight carbons, or monocyclic aryl optionally containing 1 or more lower alkyl substituents of from 1-2 carbon atoms and/or 1 or more halo (Cl or Br) substituents, aralkyl selected from benzyl and phenethyl and heterocyclic selected from 2- or 4-pyridyl, 2-pyrrolyl, 2-furyl or thiophenyl;
and R', R" and R'" are each selected from hydrogen and methyl and pharmaceutical formulation of the above compounds are active as testosterone 5α-reductase inhibitors and thus are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.
1. A compound of the formula: ##STR8## wherein R is selected from hydrogen, methyl and ethyl and
R2 is branched chain alkyl of from 3-12 carbons,
R', R", R'" are each selected from hydrogen and methyl.
2. A compound of claim 1 having the formula ##STR9## wherein R is hydrogen, methyl or ethyl and
R3 is branched chain alkyl of from 4-8 carbon atoms.
3. A compound of claim 1 wherein the compound is 22-methyl-4-aza-21-nor-5α-chol-1-ene-3,20-dione.
4. A compound of claim 1 wherein the compound is 4,22-dimethyl-4-aza-21-nor-5α-chol-1-ene-3,20-dione.
5. A compound of claim 1 wherein the compound is 23-methyl-4-aza-21-nor-5α-chol-1-ene-3,20-dione.
6. A method of treating the hyperandrogenic condition of acne vulgaris, seborrhea, female hirsutism, and benign prostatic hypertrophy comprising parenteral administration to a patient in need of such treatment of a therapeutically effective amount of a compound of formula: ##STR10## wherein R and R2 are defined as in claim 1.
7. The method of claim 6 where there is employed a compound of the formula: ##STR11## wherein R is hydrogen, methyl or ethyl and
R2 is branched chain alkyl of from 4-8 carbon atoms.
8. A method of inhibiting testosterone 5α-reductase in a patient in need of such inhibiting treatment, comprising administration to such a patient of a therapeutically effective amount of a compound of the formula: ##STR12## wherein R and R2 are defined as in claim 1,
R' is hydrogen or methyl,
R" is hydrogen or β-methyl,
R"' is hydrogen, α-methyl or β-methyl.
9. The compound of claim 8 wherein there is employed a compound of the formula: ##STR13## wherein R is selected from hydrogen, methyl and ethyl and
R3 is branched chain alkyl of from 4-8 carbon atoms.
10. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of a compound of formula: ##STR14## wherein R and R2 are defined as in claim 1.
11. The composition of claim 10 wherein there is employed a compound of the formula: ##STR15## wherein R is hydrogen, methyl or ethyl, and
R3 is branched chain alkyl of from 4-8 carbon atoms.
This is a continuation of application Ser. No. 800,624, filed Nov. 21, 1985, now abandoned, which in turn is a continuation of application Ser. No. 584,061, filed Feb. 27, 1984, now abandoned.
The present invention is concerned with novel 17β-acyl-4-aza-5α-androst-1-en-3-one compounds and the use of such compounds as testosterone-5α-reductase inhibitors.
It is well known in the art that certain undesirable physiological manifestations, such as acne vulgaris, seborrhea, female hirsutism, and male pattern baldness and benign prostatic hypertrophy, are the result of hyperandrogenic stimulation caused by an excessive accumulation of testosterone or similar androgenic hormones in the metabolic system. Early attempts to provide a chemotherapeutic agent to counter the undesirable results of hyperandrogenicity resulted in the discovery of several steroidal antiandrogens having undesirable hormonal activities of their own. The estrogens, for example, not only counteract the effect of the androgens but have a feminizing effect as well. Non-steroidal antiandrogens have also been developed, for example, 4'-nitro-3'-trifluoromethylisobutyranilide. See Neri et al., Endo., Vol. 91, Nol 2 (1972). However, these products, though devoid of hormonal effects, are peripherally active, competing with the natural androgens for receptor sites, and hence have a tendency to feminize a male host or the male fetus of a female host.
It more recently became known in the art that the principal mediator of androgenic activity in some target organs is 5α-dihydrotestosterone, and that it is formed locally in the target organ by the action of testosterone-5α-reductase. It therefore has been postulated and demonstrated that inhibitors of testosterone-5α-reductase will serve to prevent or lessen symptoms of hyperandrogenic stimulation. Nayfeh et al., Steroids, 14, 269 (1969) demonstrated in vitro that methyl 4-androsten-3-one-17β-carboxylate was a testosterone-5α-reductase inhibitor. Then Voigt and Hsia, Endocrinology, 92, 1216 (1973), Canadian Pat. No. 970,692, demonstrated that the above ester and the parent free acid, 4-androsten-3-one-17β-carboxylic acid are both active inhibitors of testosterone-5α-reductase in vitro. They further demonstrated that topical application of either testosterone or 5α-dihydrotestosterone caused enlargement of the female hamster flank organ, or androgen dependent sebaceous structure. However, concomitant administration of 4-androsten-3-one-17β-carboxylic acid or its methyl ester inhibited the response elicited by testosterone but did not inhibit the response elicited by 5α-dihydrotestosterone. These results were interpreted as indicating that the compounds were antiandrogenic by virtue of their ability to inhibit testosterone-5α-reductase.
A number of 4-aza steroid compounds are known. See, for example, U.S. Pat. Nos. 2,227,876; 3,239,417; 3,264,301; and 3,285,918; French Pat. No. 1,465,544; Doorenbos and Solomons, J. Pharm. Sci. 62, 4, pp. 638-640 (1973); Doorenbos and Brown, J. Pharm. Sci., 60, 8, pp. 1234-1235 (1971); and Doorenbos and Kim, J. Pharm. Sci., 63, 4, pp. 620-622 (1974).
In addition U.S. Pat. Nos. 4,377,584 and 4,220,775 of Rasmusson et al. describe a group of 4-aza-5α-17β-substituted-5α-androsten-3-ones which are said to be useful in the treatment of hyperandrogenic conditions. However, none of the cited references suggest that any of the novel 17β-acyl-4-aza-5α-androst-1-en-3-ones of the present invention would have utility as highly potent testosterone-5α-reductase inhibitors.
The present invention is concerned with novel 17β-acyl-4-aza-5α-androst-1-en-3-one compounds, processes for their preparation, pharmaceutical formulations comprising the novel compounds as active ingredients and methods of inhibiting testosterone-5α-reductase and of treating hyperandrogenic conditions with the novel compounds or their pharmaceutical formulations.
The present invention is concerned with 17β-acyl-4-aza-5α-androst-1-en-3-one compounds of the formula: ##STR2## wherein R is selected from hydrogen, methyl and ethyl and
R2 is a monovalent radical selected from straight and branched chain alkyl of from 1-12 carbons, or monocyclic aryl optionally containing 1 or more lower alkyl substituents of from 1-2 carbon atoms and/or 1 or more halo (Cl or Br) substituents, aralkyl selected from benzyl and phenethyl and heterocyclic selected from 2- or 4-pyridyl, 2-pyrrolyl, 2-furyl or thiophenyl and R', R" and R'" are each selected from hydrogen and methyl.
A preferred embodiment of the novel compounds of our invention is represented by the formula: ##STR3## wherein R is hydrogen, methyl or ethyl, and
R3 is branched chain alkyl, or cycloalkyl of from 4-8 carbons.
Representative compounds of the present invention including the following:
17β-(5-butylcarbonyl)-4-aza-4-methyl-5α-androst-1-en-3-one; and the corresponding compounds wherein the 4-methyl substituent is replaced in each of the above named compounds by a hydrogen or an ethyl radical.
Also included as representative compounds are any of the above indicated compounds having the alkyl of the alkyl carbonyl substituent replaced by a methyl-, ethyl-, propyl-, i-propyl-, butyl-, phenyl-, 2-, 3- or 4-tolyl-, xylyl-, 2-bromo- or 2-chlorophenyl-, 2,6-dichloro- or a 2,6-dibromophenyl carbonyl substituent or a heterocyclic substituent selected from 2 or 4-pyridyl, 2-pyrrolyl, 2-furyl or 2-thiophenyl.
The novel compounds of formula I of the present invention are prepared by a method starting with the known steroid ester of the formula: ##STR4## which includes the stages of (1) dehydrogenating said starting material to produce the corresponding compound containing a double bond in the 1,2-position of the A-ring, (2) converting the 17-carbomethoxy substituent into a 17β-acyl substituent and, if desired (3) alkylating the A-ring nitrogen to introduce 4-methyl or 4-ethyl substituents into the A-ring. In carrying out the process of the present invention, it is essential that stage (1) dehydrogenation of the 1,2-position of the steroid A-ring be carried out using a 4-aza-5α-androsten-3-one compound having no substituent other than hydrogen attached to the A-ring nitrogen. Stage (2) may consist of one or more chemical steps and if desired may take place before stage (1) for following stage (1) or stage (3).
In accordance with the process of the present invention, the products of our invention are formed by (1) heating a 17β-alkoxycarbonyl-4-aza-5α-androstan-3-one compound III with a dehydrogenating agent such as benzeneselenic anhydride in refluxing chlorobenzene to form a 17β-alkoxycarbonyl-4-aza-5α-androst-1-en-3-one (IV). (2) the formed 5α-androst-1-en-3-one compound from step (1) is reacted with sodium hydride and under anhydrous conditions in a neutral solvent such as dimethylformamide, (2) contacting the resulting reaction mixture with an alkyl (methyl or ethyl) iodide to form the corresponding 17β-alkoxycarbonyl-4-alkyl-4-aza-5α-androst-1-en-3-one (V), (3) subsequently hydrolyzing said 17β-alkoxycarbonyl-4-alkyl-4-aza-5α-androst-1-en-3-one with a strong base such as aqueous methanolic potassium hydroxide at the reflux temperature, followed by acidification and isolation of the resulting steroidal acid, 17β-carboxy-4-alkyl-4-aza-5α-androst-1-en-3-one (VI), (4) said steroidal acid is then converted to its corresponding 2-thiopyridyl ester by refluxing with triphenyl phosphine and 2,2'-dipyridyl disulfide in an inert solvent and the product 17β-(2-pyridylthiocarbonyl)-4-alkyl-4-aza-5α-androst-1-en-3-one (VII) is isolated by chromatography on silica, (5) said pyridylthio ester is then reacted with an R2 -Li or an R2 MgX (X=Cl, Br) compound such as sec-butylmagnesium chloride in tetrahydrofuran to form the desired product 17β-(sec-butylcarbonyl)-4-alkyl-4-aza-5α-androst-1-en-3-one (VIII) which is isolated by chromatography on silica gel. When the previous reaction is carried out using an R2 MgX or, an R2 -Li compound in place of sec-butylmagnesium chloride, the corresponding 17β-(acyl)-4-alkyl-4-aza-5α-androst-1-en-3-one is prepared wherein acyl is R2 carbonyl.
In accordance with the process of our invention, the corresponding 17β-acyl-4-aza-5α-androst-1-en-3-one XV is readily prepared from the 17β(alkoxycarbonyl)-4-aza-5α-androsten-3-one (IV) by repeating the above series of reaction steps but omitting step 2 hereinabove, i.e., treatment of the 4-aza-5α-androst-1-en-3-one with sodium amide followed by methyl or ethyl iodide.
In accordance with a further alternate process of preparing the compounds of our invention, having only hydrogen as the sole substituent on the ring A-nitrogen, the Δ' double bond in the A-ring is introduced as the last step of the process. Thus, a 17β-alkoxycarbonyl-4-aza-5α-androstan-3-one (III) is hydrolyzed to the corresponding steroidal acid, 17β-carboxy-4-aza-5α-androstan-3-one, (IX) which, in turn, is converted to the corresponding thiopyridyl ester, 17β-(2-pyridylthiocarbonyl)-4-aza-5α-androstan-1-one (X) followed by treatment of the ester with an R2 MgX or R2 Li compound wherein R2 is as defined hereinabove to form a 17β-(acyl)-4-aza-5α-androstan-3-one (XI) which is dehydrogenated as previously described to produce compound XIV, 17β-(acyl)-4-aza-5α-androst-1-en-3-one.
The 16 methyl derivative wherein R'" is methyl are prepared from known 16-methyl-17-acyl-4-methyl-4-aza-5α-androstan-3-ones, e.g. 4,16β-dimethyl-17β-acetyl-4-aza-5α-androstan-3-one by known dehydrogenation procedures for 4-methyl-4-aza compounds to produce the corresponding 4,16β-dimethyl-17β-acetyl-4-aza-5α-androst-1-en-3-one.
The above reactions are schematically represented in the following structural outline: ##STR5## wherein X is a 2-pyridylthio substituent and R2 is defined as hereinabove.
The compounds of the present invention, prepared in accordance with the method described above, are, as already described, potent antiandrogens by virtue of their ability to specifically inhibit testosterone-5α-reductase.
Accordingly, the present invention is particularly concerned with providing a method of treating the hyperandrogenic conditions of acne vulgaris, seborrhea, and female hirsutism by topical administration, and a method of treating all of the above conditions as well as benign prostatic hypertrophy, by parenteral administration, of the novel compounds of the present invention.
The present invention is thus also concerned with providing suitable topical and parenteral pharmaceutical formulations for use in the novel methods of treatment of the present invention.
The compositions containing the compounds of the present invention as the active ingredient for use in the treatment of benign prostatic hypertrophy can be administered in a wide variety of therapeutic dosage forms in conventional vehicles for systemic administration, as, for example, by oral administration in the form of tablets, capsules, solutions, or suspensions, of by intravenous injection. The daily dosage of the products may be varied over a wide range varying from 50 to 2,000 mg. The compositions are preferably provided in the form of scored tablets containing 5, 10, 25, 50, 100, 150, 250, and 500 milligrams of the active ingredient for the symptomatic adjustment of the dosage to the patient to be treated. An effective amount of the drug is ordinarily supplied at a dosage level of from about 1 mg to about 50 mg/kg of body weight per day. Preferably the range is from about 1 mg to 7 mg/kg of body weight per day. These dosages are well below the toxic dose of the product. Capsules containing the product of this invention can be prepared by mixing an active compound of the present invention with lactose and magnesium stearate, calcium stearate, starch, talc, or other carriers, and placing the mixture in gelatin capsule. Tablets may be prepared by mixing the active ingredient with conventional tableting ingredients such as calcium phosphate, lactose, corn starch or magnesium stearate. The liquid forms in suitably flavored suspending or dispersing agents such as the synthetic and natural gums, for example, tragacanth, acacia, methylcellulose and the like. Other dispersing agents which may be employed include glycerin and the like. For parenteral administration sterile suspensions and solutions are desired. Isotonic preparations which generally contain suitable preservative are employed when intravenous administration is desired.
For the treatment of acne vulgaris, seborrhea, female hirsutism, the compounds of the present invention are administrated in the formula of pharmaceutical composition comprising the active compound in combination with a pharmacologically acceptable carrier adapted for topical administration. These topical pharmaceutical compositions may be in the form of cream, ointment, gel or aerosol formulation adopted for application to the skin. These topical pharmaceutical compositions containing the compounds of the present invention ordinarily include about 0.1% to 15%, preferably about 5%, of the active compound, in admixture with about 95% of vehicle.
The method of preparing the novel compounds of the present invention, already described above in general terms, may be further illustrated by the following examples.
To a solution of 7.2 g of S-(2-pyridyl)-3-oxo-4-aza-5α-androst-1-ene-17β-thiocarboxylate in 288 ml of tetrahydrofuran was added at -78░ C. 33.6 ml of 1.3M S-butylmagnesium chloride. After 30 minutes at -78░ C. the solution came to room temperature and was treated with saturated aqueous NaCl solution. The product was extracted into dichloromethane and was washed with saturated aqueous NaCl solution and 10% aqueous NaOH solution, then dried and concentrated. The residue was eluted through 430 g of silica gel with 9:1 dichloromethane-acetone to give 4.5 g of the product, m.p. 246░-249░ C.
When the procedure is repeated using the following reagents, the indicated product is obtained.
______________________________________StartingMaterial Reagent Product______________________________________S--(2-pyridyl)3- 2-pyrrolyl mag- 17β-(2-pyrrolyl-oxo-4-aza-5α- nesium chloride carbonyl)-4-aza-androst-1-en- 5α-androst-1-en-17β-thiocarboxylate 3-one m.p. 294-296░ C.S-(2-pyridyl)3- sec-butyl mag- 4,22-dimethyl-4-oxo-4-methyl-5α- nesium chloride aza-21-nor-5α-androst-1-en-17β- chol-1-en-3,20-dionethiocarboxylate m.p. 134-136░ C.S-(2-pyridyl)3- 2-pyrrolyl mag- 4-methyl-17β-(2-oxo-4-methyl-4- nesium chloride pyrrolylcarbonyl)-aza-5α-androst- 4-aza-5α-androst-1-en-17β-thio- 1-en-3-onecarboxylate m.p. 234-238░ C.S-(2-pyridyl)3- isobutyl mag- 23-methyl-4-aza-oxo-4-aza-5α- nesium chloride 21-nor-5α-androst-en-17β- cholane-3,20-thiocarboxylate dione m.p. 220-222░ C.______________________________________
A solution of 21 g of 22-methyl-4-aza-21-nor-5α-cholane-3,20-dione (Step 1) and 29.49 g of benzeneseleninic anhydride in 552 ml of chlorobenzene was refluxed with water separation for 4 hours. The mixture was concentrated and the residue was redissolved in dichloromethane. After washing with 10% aqueous sodium hydroxide, then 10% hydrochloric acid and saturated aqueous sodium chloride the solution was dried and concentrated to 45 g of yellow residue. This was chromatographed on 1.5 kg of silica gel packed in dichloromethane and eluted with ethyl acetate to give 10.6 g of the product, m.p. 248░-251░ C.
When the procedure is repeated using 23-methyl-4-aza-21-nor-5α-cholane-3,20-dione as starting material the product is obtained is 23-methyl-1-aza-21-nor-5α-chol-1-ene-3,20-dione, m.p. 283░-286░ C.
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text:
Dunkers Deluxe: Peace Love & Little Donuts gets its groove on in Naples
NAPLES - Where: South side of Wayne's World BP, 2201 U.S. 41 N., Naples
When: Hours are 7 a.m. to 2 p.m. daily, 9 a.m. to 4 p.m. Saturday, and 9 a.m. to 2 p.m. Sunday
Cost: 85 cents to $1.29 for custom-made doughnuts
Information: (239) 213-0188
Facebook page: http://www.hs.facebook.com/pages/Peace-Love-Little-Donuts/203313916366718?sk=wall
Evident by its unique name, Peace Love & Little Donuts is not your ordinary doughnut shop.
In fact, answers to frequently asked questions about this doughnut drive-through that opened last week in Naples Plaza would prove that not only its name separates it from the rest.
Is it true the new shop operates from the converted bay of a gas station? Yes. Peace Love & Little Doughnuts shares space with Wayne's World BP at 2201 U.S. 41 N., a half-acre lot on the southwest corner of Mooring Line Drive and U.S. 41 in Naples, near Coastland Center mall.
"The response has been really good. People are a little bit surprised we have a drive-through," said Mark Couch, owner of the local venture.
The shop is an attraction, rather than a distraction for the service station, which has been operating there for nearly 35 years. The interior walls of the small shop are painted with brightly colored flowers reminiscent of the "Dating Game," "Laugh-In" or Scooby Doo's Mystery Machine van.
Do they really make little doughnuts? That's right. While the average doughnut is 3 inches to 3½ inches in diameter, most doughnuts made by Peace Love & Little Doughnuts are smaller at 2 inches to 2¼ inches in diameter.
"Our doughnuts are 60 to 65 percent of the size of a regular doughnut," Couch said.
Is the doughnuts' cake batter different, too? Yes, the new shop features doughnuts made from three batters: sour cream, blueberry and devil's food. From these bases, the cake doughnuts are "dressed" as ordered.
"It's the foodie concept of the cupcake blended with a doughnut," Couch said.
And these doughnuts feature far-out toppings? Let's just say that if Ben & Jerry made doughnuts instead of ice cream, they probably would come up with some of the funky options here. Sweet creations are inspired by desserts, candy bars, fruit and cookies and come in varieties such as apple pie, blueberry cheesecake, banana split, pina colada, S'more and sweet chocolate coconut doughnuts.
Some are topped with items such as cherries, Oreo cookie pieces or Nestle Crunch bars.
"The chunkier the better," Couch said. "Abundance creates activity."
What are the most popular doughnuts? Raspberry lemonade doughnuts, which feature a lemonade frosting with a raspberry drizzle, are big-time favorites for women. Guys love the maple bacon doughnut, which feature maple frosting topped with real chopped bacon, Couch said.
Peace Love makes 32 different doughnuts, including 15 main "staple" doughnuts daily.
"We don't make every single doughnut every day," Couch said.
The little doughnuts have three price brackets:
■ Groovy, 85 cents each for the basic doughnut, whether it is plain, glazed, or covered with powdered sugar, cinnamon sugar or maple sugar.
■ Far out, $1 each for a doughnut with any hand-dipped, flavored frosting.
■ Funkadelic, $1.29 each for a combination of any toppings and frosting.
What about coffee? The brew served is special, too. The shop specially grinds its own blend of seasonal gourmet coffees from Africa and South America.
Is this new shop part of a national chain? Not yet. The Naples store is licensed to use the name and concept, but is not a franchise.
Peace Love & Little Doughnuts began in 2009 in Pittsburgh, where the only other two stores are located. A fourth location is scheduled to open before the end of the month in Cleveland.
"They created a great brand and a great following with a good business model. I said, let's bring it to Naples," said Couch, a military veteran who lives nearby in the Moorings.
After serving in the Gulf War and being a mechanic on the USS Midway, Couch was a pilot for 13 years. He started as a flight instructor and worked for US Airways for the majority of his flying career, but he also has been a pilot for cargo planes, private jets and luxury airliners.
After a pilot job fell through in Florida, the gregarious Naples newlywed sought out a career change. He found Peace Love & Little Doughnuts.
Subscribe to the Naples Daily News
Need Help? Call us at 1-888-878-6842.
Monday-Friday: 6am-6pm / Saturday: 7am-3pm / Sunday: 7am-2pm


text:
Automating the world one-liner at a time…
I've been working with the folks over at Developer Zone on a quick reference card for PowerShell, based on my book. The card is now complete and is available as a free download. (PDF, registration required.)
This is an 8-page card that covers the PowerShell language, common commands and examples. The card was written primarily for developers (it is Developer Zone after all) and for people with existing scripting experience. Even so, if you're using PowerShell, it should be a handy reference to the environment.
Thanks -bruce
=============================== Bruce Payette [MSFT] Principal Developer, Windows PowerShell Team
Thanks for doing such a great job on the Windows PowerShell refcard, Bruce. I really believe it will be useful to everyone who gets it.
We're going to be sending this one to the printer soon, so I will get you some copies as soon as we get them back!
Its not really free if you have to register, why not just share it up?
Unable to connect to database server
If you still have to install Drupal, proceed to the installation page.
If you have already finished installing Drupal, this either means that the username and password information in your settings.php file is incorrect or that we can't connect to the MySQL database server. This could mean your hosting provider's database server is down.
The MySQL error was: Can't connect to local MySQL server through socket '/var/run/mysqld/mysqld.sock' (2).
Currently, the username is dztest and the database server is localhost.
Are you sure you have the correct username and password?
Are you sure that you have typed the correct hostname?
Are you sure that the database server is running?
For more help, see the Installation and upgrading handbook. If you are unsure what these terms mean you should probably contact your hosting provider.
Im not the best at powershell, but this looks wrong. Page 6, Operators for working with types.
-is example: $true -is [object] | $true | This is always true – everything is
an object except $null <- sounds good
-isnot example: $true -isnot [object] | $true | The null value is the only thing that
isn't an object.
shouldnt this return $false because $true is not null, making it an object?
btw there's a typo on the first sentence:
"...provide a powerful, well-integrated command-line experience for the operation system"
You could fix the typo by...
"operation" -replace "on", "ng"
I appreciate the cheat sheet (at least I will as soon as I register for yet another developer site), but I also agree that it should be available without registration.
Frankly, even with the "Graphical Documentation", the state of PowerShell 1.0's documentation is appalling. Searching blogs is the best way to find out shell syntax and features. While I will admit that searching the web is great for SUPPLEMENTING the core documentation, I don't think it should SUPPLANT the core documentation.
Since the cmdlets are all self-documenting, why does the "Getting Started" guide not provide all of the syntax and less about cmdlets? After all, knowing which about_* help topic you want is hit or miss...
I'm hoping that PowerShell 2.0 includes something a little closer to MSDN Library standards.
On page 2, in the Commands table:
"... documnets for with there are ..."
should be
"... documnets for which there are ..."
Thought I would help the state of documentation along with some proofreading / suggestions:
Microsoft would probably appreciate it if you capitalized Word in the Commands table on page 2.
The first while Loop example is an infinite loop.
I think the first Unary Operator should be negation (and not assignment); the example and results are right, but the operator and description are not. There is a similar issue with the unary plus operator. The descriptions of the type cast and array (comma) operators are wrong.
What's the difference between Set-Item and Set-Content
The Corresponding .NET Types for all of the entries between and including [array] and [switch] are wrong; the correct entry for [array] is missing and the rest are shifted up one cell.
It would be nice if there was a little more exposition on the [switch] type; it is quite powerful, very useful, and I had to discover its workings on my own.
Does the -as operator throw an exception or just return $null on failure? I know I can find that out easily for myself, but it's the sort of thing that would be handy in the cheat sheet.
There seems to be a misplaced bit of text on page 6 at the end of "Accessing Instance Members:" :
"Working With Collections: ForEach-Object, Where-Object"
They were already discussed in "Flow-control Statements:" by their aliases.
In the hot tip on page 6, you might want to say "the beginning of 2006" instead of "the beginning of this year". Of course that alters your other examples, so maybe you want to use $now.Year + "/01/01". Likewise with the Christmas examples.
You might want to mention New-Object in the .NET section as well as the COM section.
In the COM section, you might want to change "used as the Windows automation mechanism" to "used as a Windows automation mechanism".
The usage here-string for Get-Spelling should probably be in the format for PowerShell script used in the rest of the document, instead of the format for body text.
The header on page 8 "BUILDING CUSTOM OBJECTS IN POWERSHELL" is wrong; it should be about errors and debugging instead.
"The behavior of the trap statement can be altered with the break and continue statements." How?
Jeez, they sure want a lot of information to register, too much for me.
That website wants to know WAY TOO MUCH about me.
I'm a big fan of PS and I'd love to have a copy of this PDF.
But their profile data looks like it was designed to be sold. I'm really tired of unsolicited crap resulting from my address and profile being sold by websites like these. Sorry, they just don't look trustworthy!
Bruce, I hope whatever they paid you for this content was worth keeping it locked away behind their shady registration.
And they seem to think that names and cities should not be the single character "a"
Way too much BS for me. I will go without
As usual nothing in this world is really for free.
You pay with a lot of personal information, and that could ending up being very expensive.
I can't afford the cost of the registration!
Id does not look right to ask for detailed registration to download "free" Quick Reference Card. It is a way you collect information about users and registration should be optional is the only thing user is interested in is a download.
I'm going to download this document from P2P, not from here.


text:
- Filed Under
Prodded to be more candid with Congress, Health and Human Services Secretary Kathleen Sebelius said Wednesday that the administration's flawed health care website needed a couple of hundred fixes when it went online more than a month ago and conceded, "we're not there yet" in making all needed repairs.
But she turned aside any suggestion that the system be taken offline until it could be fixed fully. Doing so "wouldn't delay people's cancer or diabetes or Parkinson's" disease, she told the Senate Finance Committee.
Panel Chairman Sen. Max Baucus, D-Mont., said Sebelius must be "candidly, ...


text:
While on tour to the mysterious planet Abulon, the pleasure-loving hermaphrodites of the Merculian National Dance Company are intrigued by the virile patriarchal society they discover there. The natives seem friendly enough, but when the star's young lover is kidnapped, the Merculians find themselves plunged into an alien civil war that they are ill-equipped to survive. QUOTES/REVIEWS "Caro Soles has written a crackerjack SF novel -- moving, eloquent, and richly… (più)
Editore: Untreed Reads Publishing (18 Settembre 2012)
Format: EPUB
Dimensioni del file: 309 KB
Protezione: DRM
Lingua: Inglese


text:
Today I have another chunky holo to share... I know, I'm obsessed. I knew I wanted to use Chunky Holo Fuchsia (I think I'm pretty good at spelling but fuchsia has always been one of my "problem" words - English is so strange sometimes) for pink Wednesday but I knew I'd have to layer it over a pink to get it to "count". I want to be able to sit with you guys!
Also it's almost 1:30 AM as I write this and it sounds like they're power cleaning the streets. SERIOUSLY. With the beeping trucks and everything. Mind blown.
Anyway, I layered two coats of Chunky Holo Fuchsia (bahhh I still don't get the "holo" bit) over two coats of China Glaze Ahoy!. I know. You're not surprised that I used Ahoy! at all are you? I can't help it. It's pretty much perfect. I might have to create an Ahoy! label just to track how much I use it LOL. I didn't take any sunlight pictures because the dinosaur egg thing kinda creeps me out... and anyway, they don't look that interesting in the sunlight! ;)
Anyway, that's it! I love these. You need them. In the bottle, these look mental. On the nail, I don't really see any of the blue that flashes in this one (by the way, these are all numbered - this one is 230! Cool, eh?) but maybe if I picked a different base colour I'd see it? I'll have to experiment with the next one I have to wear!
What do you guys think? Are you rocking pink today? What's your favourite duochrome or multichrome polish? Are you weird like me and enjoy when polishes smell strong and chemically? I like this infamous Kleancolor smell haha!
Thanks for reading! Have a beautiful day!


text:
Edinburgh - 0131 557 5830
We offer the most competitive rates in the city and 511 (downstairs from The Newsroom) is available to hire for private functions ranging from live comedy, parties, wedding celebrations, office events and much more. DJs, catering and bar staff can be arranged on request - Please contact email@example.com for more details.
511 gives the feeling of a red lit basement, with ample sound and the best staff. Add the Burgh family into the mix and its a memorable night out - Phil Asher
511 is what most DJ's would consider a perfect small venue and I for one really loved playing there. Low ceiling, dim red lighting, cracking sound system, friendly and clued up crowd not to mention a Condesa mixer to play on! What more do you want? Hope to come back soon! - Jimpster
Let us entertain you
The Newsroom is a hub of live entertainment and music every week. From pre-club to the soundtrack to your night our entertainment is sure to suit every taste. Find out more


text:
The Latest
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Digital Dream Labs isn't going to create any five-year-old programming prodigies with Puzzlets, but they're hoping to foster an early affinity for STEAM learning that will lay the ...
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Gene Roddenbery's White Room: 02B3 is Reinvented for 360° VR App
The late Gene Roddenberry was once at the forefront of science fiction — with Roddenberry 360°, his son Rod might be following in his footsteps. The new venture ...
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Helix Sleep Wants to Make a Mattress Just For You
Casper started a revolution in the mattress industry. Endy followed that trend. And now, Helix Sleep thinks they've found a better way — custom, made-to-order mattresses tailor made ...
Laptops 0
EcoTank Printers Will Last for Two Years on a Single Ink Cartridge
Epson's announcement today is going to be big news for anyone who still uses their printer a lot. To that effect, their new EcoTank line of printers are ...
Latest Reviews
Simplicam Review
Are you looking for a home security camera to check up on your kids at home or even keep tabs on your pet while you're at the office? ...
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At the risk of adding more worthless words to the Barnumesque onslaught that has turned a lion into a circus act more in death than in life, Cecil ...
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If you're a regular around these parts, you know that two of our favorite things are Hello Kitty and the Simpsons. Yet somehow, we never dared to dream ...
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After coming out with the impressive Plantronics BackBeat Pro wireless headphones, it was only a matter of time before Plantronics released Bluetooth headphones that don't weigh your head ...
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Summer is in full swing and you want to throw an amazing outdoor viewing party — this is the natural domain of the projector. We've looked at quite ...
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Probably should be implied, but no harm in being explicit — AT&T's 'It Can Wait' program, initiated to warn against the dangers of texting and driving, is expanding ...
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Mission Impossible: Rogue Nation IMAX Review
Mission Impossible has always been the anti-bond, and its latest installment, really proves that sentiment. The film also contains signature staples of the Mission Impossible movies. That means ...
Here's the Most Boring Accessory Every Home Theater Should Have
Got both a PlayStation 4 and an Xbox One? Maybe even have a Wii U? Still have that Blu-ray player kicking around? Need to harangue the rest of ...
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Social media has a new hero. I don't know if it needed a new hero, but it certainly deserves Stikbot, a poseable if somewhat featureless robot inexplicably supplied ...


text:
Older Americans who are eligible for SNAP/Food Stamps are significantly less likely to participate in the program than other demographic groups. Only one-third of eligible seniors benefit from the program. Many factors contribute to this low participation rate, from barriers related to mobility, technology, and stigma, to widespread myths about how the program works and who can qualify.
Studies have shown that one of the key reasons the elderly do not participate in the SNAP/Food Stamp Program is because they mistakenly believe they will only get the minimum benefit ($16).
Seniors are less likely to be aware of their potential eligibility than the average eligible nonparticipant.
Stigma plays a particularly important role. Seniors have cited worries about how they might be perceived by grocery store staff and other shoppers, and about the embarrassment they might feel if family and friends knew they received benefits.
The application process can also be daunting, from the paperwork involved to the technology used.


text:
Occidental College
Career Development Center
The CDC 2013-2014 Year in Review Is Awesome!
June 11, 2014
The CDC uses Storify to recap the '13-'14 school year and all the awesome things we did. Check it out!
The CDC has had a busy year with a lot of firsts and exciting events. We get nostalgic and look back at some of this past year's highlights using Storify. Scroll down to see what we were up to.
- Phone: (323) 259-2623
- Fax: (323) 341-4900
- Email: email@example.com
- Address: AGC 109
1600 Campus Road
Los Angeles, CA 90041 & The Career Corner JSC 134
- Online:
<---TIGERlink Log-in for Jobs, Internships, Appointments
Job Search Guides
OxyCareers Facebook
OxyCareers Google+
OxyCareers Twitter
OxyCareers Pinterest
OxyCareers Instagram
OxyCareers YouTube


text:
Taking into account several important factors beyond the program's control, the committee found that since 2001 (the period covered by this review), the PPT Program has made meaningful contributions to improving worker health and safety. Using a five-point scoring scale (where 5 is highest), the committee assigned the NIOSH PPT Program a score of 4 for relevance. This score reflects the judgment that the PPT Program is working in priority areas and is engaged in transferring its research to improved products and processes. The committee also assigned the PPT Program a score of 4 for impact, indicating that the program has made probable contributions to end outcomes (improvements in worker health or safety) in addition to well-accepted intermediate outcomes.
To enhance the relevance and impact of its work, the committee recommends the development of a National PPT Program consistent with the original congressional mandate that would foster the development of improved protection for all workers through coordinated oversight of all PPT. The committee also recommends that the PPT Program establish research centers of excellence, enhance the respirator certification process, increase research on the use and usability of PPT, and assess PPT use and effectiveness in the workplace using a life-cycle approach.
Maintaining the health and safety of workers in the United States and globally is accomplished in part by reducing hazardous exposures through the use of personal protective equipment. Personal protective technologies (PPT) include respirators worn by construction workers and miners to protect against exposure to silica, dust, and hazardous gases; protective clothing, respirators, and gloves worn by firefighters and mine rescue workers to avoid burns and smoke inhalation; and respirators and protective clothing worn by healthcare workers to prevent acquiring an infectious disease. An estimated 5 million workers are required to wear respirators in 1.3 million U.S. workplaces. For some occupations, such as firefighting, the worker's protective equipment is the only form of protection against life-threatening hazards; for other workers, PPT is a supplement to ventilation and other environmental, engineering, or administrative hazard controls.
In the United States, federal responsibility for civilian worker PPT is integral to the mission of the National Institute for Occupational Safety and Health (NIOSH). This report examines the NIOSH Personal Protective Technology Program (PPT Program) and specifically focuses on the relevance and impact of this program in reducing hazardous exposures and improving worker health and safety.


text:
Safari using 6GB of RAM?
I'm not sure if this belongs in the applications or the OS forum, but my apologies if it's in the wrong place.
I'm running 10.6.6 on a 27" iMac. I have no plug-ins other than AdBlocker installed on Safari, and all of my software is up to date. I've noticed my machine running a little sluggish the last day or so, and activity monitor shows that Safari (with just one tab) is using almost 6GB of RAM. When I open it, it starts out around 300MB and within a minute or two my activity monitor shows almost 6B of Real Mem used.
Things I've tried:
- Cleared the history cache
- Disable accelerated composting
- Disable back/foward cache
- Disable AdBlocker
- Cleaned everything out with Onyx, including all cookies, logs, cache, etc
Basically Safari open at all is killing every other app that I run on my system. Google Chrome, for comparison, uses around 30MB of RAM with one tab open.
I've been Googling like a maniac, but everything I find points to cache, and I'm not really sure what else to try.
Thanks in advance. :)
Bah, murphy's law - as soon as you post something, you find the answer.
I had AdBlocker disabled, but the Plugin file still existed in /Library/Application Support/SIMBL/Plugins.
Deleting it entirely and relaunching Safari seemed to do the trick, in case anyone else finds this via Google or so.
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text:
New to WikiBios? Here's how you can get started!
*Create a WikiBio
Make a WikiBio for yourself or for someone you want to write about. You can upload a picture, add your vital information and picture, and customize the sections that people can edit to make your WikiBio all your own. >>
*Invite Editors
Make your WikiBio grow by inviting others to add information to it. Invite your friends, family, coworkers, or anyone else who you think can help let the world know about you. You can also invite editors by using our "Wiki My Bio!" graphics and icons. >>
*Edit People's WikiBios
Find a friend's WikiBio and help tell his or her story. Don't forget: the best way to get people to edit your own bio is to edit theirs. Use our search figure to find your friends, and if they don't have one yet, invite them to join! >>
*Customize Your WikiBio
NEW! Use our new "skins" feature to customize many aspects of your WikiBio. You can change the colors of various parts of your WikiBio, including the background, font, and headline colors. You can also create a custom WikiBios logo for the top of your page! >>
*Write Your Introduction
NEW! While the premise behind WikiBios is that your friends and family write about your life, we do allow you to write a short paragraph to introduce yourself. This is your chance to let people know about you through your own words before they write about you. >>
*Show Off Media in Your WikiBio
Coming Soon! Add music and videos to your WikiBio in your own media portfolio. Both you and others can add media to your portfolio. Use it to show off your unique and interesting talents! >>
*Connect With Your Friends
NEW! You can now connect your WikiBio to those of your friends and family! Simply click on the "Add As Friend" button on their profile and when they confirm your friendship, your profiles will be linked. Once you have friends, you can then work together to make sure each others' WikiBios are chock-full of biographical goodness. >>
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A peak into NYC society life, written by the author of the Sex and the City novel that started it all! Different than Sex in the City because there are a variety of people here from different generations and financial backgrounds. Bushnell gives us lots of colorful characters! And her writing style makes you feel like a voyeur reading it…getting a sneak peak into everyone's social life. Ever wonder about the rich and famous? Or the not-so rich and famous? Well, if so, this is the book for you. A fun read!
About Cecilia C.
I order the DVDs, Blu-rays, and Audiobooks at the Niles Library. I love movies almost as much as I love being a librarian. Also, I am an Anglophile, Hitchcock-phile, destined to move to London/England one day, loves to travel (Europe), loves to read, wishes for some more time to write.


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Certificate programs offer M. Arch. students the opportunity to focus their elective coursework and begin to develop a specialization in a subject area. The successful completion of a certificate program will be noted on the graduate's transcript. Note that Certificate Programs are elective and take place in the same semesters as off-campus study; therefore, it is not necessarily possible to do both.
The School of Architecture offers two certificate programs to graduate and post-graduate architecture students:
Click the images to visit their webpages.
Open the original version of this page.
Usablenet Assistive is a Usablenet product. Usablenet Assistive Main Page.


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Verizon to release Lumia 822 and HTC 8X in time for Black Friday
Verizon has announced that it will be releasing the Nokia Lumia 822 and the HTC 8X Windows Phone smartphones by Thanksgiving, giving Black Friday shoppers a chance to nab them for Christmas. Both these phones run Windows Phone 8, and complement Verizon's previously only-available Windows Phone, the HTC Trophy. You can grab the 8X for $199.99, and the Lumia 822 for $99.99 after rebate.


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Chilly, Pockets of Light Showers TodayMay 17th, 2014 at 7:07 am by Ken Brewer under Weather
TODAY: There are a lot of outdoor activities going on across central Indiana today. The best advice for all is to bundle up and keep an umbrella handy. Overall, rain chances will be lower than Friday, but it will still be chilly. Highs will only reach the mid to upper 50s in most places.
INDY 11 / EVENING FORECAST: As the daytime heating goes away, clouds and scattered showers will go away. Cold air will move in and we will drop to the low 50s for most of the evening.
PATCHY FROST TONIGHT: With clear skies, cold air, and light wind, there will be areas of frost. If you have sensitive plants, you want to protect those tonight.
BETTER SUNDAY: Expect more sunshine and milder air. Highs will reach the mid to upper 60s!
8-DAY FORECAST: Dry, warmer weather will arrive through Tuesday. Highs will climb into the 70s and approach 80 degrees. Scattered showers and thunderstorms will return Wednesday through Friday. The weekend looks to be ok temperature wise, but there may be a chance of scattered showers and storms. Models are not in agreement on this, so the forecast will need to be updated as more information comes in.


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Eating Out
Looking for Deli and Pizza in Midtown Manhattan
Hi All,
I'm headed to NYC tomorrow for a business trip, and I'm looking for some recommendations of places to eat in Midtown area near East 27th Street. Because I'm working from 8-530, I'd prefer places within walking distances. Thanks for any tips!
Talk is closed, but that doesn't mean the conversations have to stop!
Check out this post for a more thorough explanation, and jump onto our Facebook page or our Twitter feed to keep the conversations going!


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Dec. 7, 2010
Recap | Box Score | Photo Gallery
Coach Flanagan Quotes
Opening Statement:
This was one of the poorest games I've ever been involved in. We didn't get back on defense, we didn't box out, we didn't deny the outlet, and we allowed them to run faster with the ball than we were running without the ball. We need to go back to square one. You're always concerned when you have a lot of freshmen playing that they'll play like freshmen and that's what they did. A lot of the older players didn't help either, they didn't step up. I do have to mention Jourdan Erskine though, she was playing in pain and I thought she had a good game.
Jasmine Patterson had a good game, she's a freshman, but she put pressure on them and I feel that she was one of the only players out there that was giving them trouble on the offense.
Our offense was slow. Sometimes when you play a lot of games in a row you can make an excuse that they have tired legs, but I don't want to make an excuse. We need to get in better shape, we need to run the floor better, and this was just a poor game to play at home. I'm disappointed.
I thought we were a pretty good defensive team until today. We have to go back and go to work. We have a more successful and higher ranked opponent on Sunday (in Oklahoma) so we have to do a lot in a short period of time."
New Mexico Guard Amanda Best
Best: "It was very frustrating; we didn't play well in any aspect of the game."
Addressing how the team performed the first ten minutes of the game:
Best: "That start kind of paved the way for the rest of the game; we couldn't really get out of that trap. We tried at the midpoint and had a small comeback, but we just couldn't get over the hump."
What do you have to do to prepare for Oklahoma?
Best: "We have to just forget it. We have to learn from what happened, but we also have to focus and get back to playing good basketball. Our defense has been well this year, but tonight was a poor effort so we have to focus on that as well."
Arizona Head Coach Butts
Arizona Head Coach Butts on the overall game
"I think our team responded after a tough loss at Nevada. I think coming on the road to a tough environment like The Pit, the first time here for us as coaches, first time here for us as a team, we responded well. We jumped on them well and did a really good job of pushing the ball."
Butts on playing in the Pit
"I think it was a great environment. It's something that's going to help us down the road."


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K @ B Yogurt is a new TRENDY Self-serv Yogurt and Topping Bar in Bakersfield that has a fresh new innovative look with the personal touch. No weighing of yogurt. That's right, we went their. No scales, No weighing. The days of the scales are gone, and your toppings are free. All our yogurt is nonfat and, some with no sugar.
At K @ B Yogurt, we are focused on providing customer services with the highest levels of customer satisfaction and we will do everything we can to meet your expectation.
With a variety of flavors and toppings to choose from, we're sure you'll be able to find your combination.
We use YOCREAM nonfat yogurt that contains less that .5g of dairy butter fat per serving. A tasty 4 ounce serving contains anywhere from 100-110 calories, depending on the frozen yogurt flavor. yocream nonfat yogurt is specially crafted to provide a rich and creamy mouth feel while delivering a nonfat experience.
Look around our website and if you have any comments or questions, please feel free to contact us. We hope to see you again!
Check back later for new updates to our website. There's much more to come. Thank You.


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August 3, 2015
A security guard making his rounds at a shopping center in The Woodlands this morning saw a man lying on the ground, and didn't expect what happened next.
The man on ground said he needed his inhaler. Then another man came out of the trees pointing an assault weapon at the guard. The man asking for the inhaler also pulled an assault rifle on the guard.
Police say the men beat the guard then stole his truck and crashed it through the front glass of a gun store. Once in the building they stole several weapons and merchandise.
So far no reports of any arrests.
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Found this! try check Jamie Bower as Caius in Breaking Dawn part 1 End scenes.
Jamie Bower revealed how he think about his role in Twilight movie which he play as Caius.
"In the last film, New Moon, there's a scene where we rip this guy apart," he said with a little too much enthusiasm.
"It was gross and grim, and my character just sat there smiling and enjoying it. When I got the script, I knew that was the one I wanted the most."
2 few page scans from Time magazine November 2009 issue. have show Jamie as Caius


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Hold down Control (PC) or Command (Mac) key + mouseclick to select more than one option
|Avg. Dinner Entrée
|Greater than $25
|$18.01 - $25
|$12.01 - $18
|$7.01 - $12
|Less than $7
Posted by Josh Karpf on 03/18/2011
Duke's once offered several BBQ options, and it was good meat even when it was oversauced. I don't remember whether it was actually smoked, but it was at least barbecue style. But our last brunch there was not only bland and overcooked, it could've been from any generic American restaurant. And on our last evening visit, we found that only two 'cue items remained on the menu, a pulled-pork sandwich or a plate of ribs. The rest was salads, burgers, fried chicken, and misc. apps. Duke's was once barbecue style. Now it's barbecue-style-style.
Posted by John Splinter on 03/05/2011
Gotta say no frills just a solid simple place to grab food and enjoy time with friends. Wonderful spot to watch a game, Yankees baseball is around the corner! Save me a seat at the bar...
Posted by shabuchwae on 07/29/2010
I only gave 3-stars because the Signature Cocktails are strong and flavorful...and because I had a birthday coupon for a free entree. Besides that, I'd be seriously griping about paying midtown tourist prices for small town bar food. My advice? Go during the 4-7 or 11-close happy hours. Half price booze, beer & apps. I'll most definitely go back on the decently regular for that deal. But paying full price for sub-par service, craptastic tables, hit or miss food, and music so loud that my ears range afterward? Me no think so.
Posted by Robbie on 07/13/2010
When I walked in with my two friends, we were told to have a seat anywhere, and then we were escorted to a booth in the back of the restaurant. The AC must not have been working because it was very warm and uncomfortable and not a good temperature to comfortably eat at. We ordered the mac and cheese for an appetizer which was really quite delicious. However the meal only went down hill from there. I ordered pulled pork which was almost black in color, and tasted disgusting. The bun was too big and sogggy, and like I said the meat itself tasted horrible. The waitress was unattentive and only had about 3 tables including mine. I would never recommend this place, and would probably never go again!
Posted by Anonymous on 04/06/2010
I actually happen to like the food at this Duke's as well as the other one on 3rd, however my last experience here was atrocious. We were basically the only people in the dining room, yet somehow managed to have the slowest service I've ever had. To top that off, we were served warm pitchers of beer, even after complaining about it.
Posted by anonymous on 01/26/2010
Everything we ordered tasted subpar. Drinks, lunch, snacks. I would avoid this restaurant. I feel bad for the wait stuff though.
Posted by Lily on 01/12/2010
I feel like I stepped into a country bar when I first went to this restaurant. The girls were rude, the men were loud, and there were drunks at the bar. However, the dining area isn't so bad and the food can make up for the horrible service and the disgusting people who come into the restaurant sometimes (as long as you come with good enough company to make you forget these things). The portions are huge and can be shared with at least one other person. I recommend the chicken breast, YUM!


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Hold down Control (PC) or Command (Mac) key + mouseclick to select more than one option
|Avg. Dinner Entrée
|Greater than $25
|$18.01 - $25
|$12.01 - $18
|$7.01 - $12
|Less than $7
Posted by Anonymous on 02/08/2005
Downside: the waiters are kind of cranky and it can get crowded (with little kids...) sometimes. But my mainstays of pizza, baked ziti, ravioli and eggplant parm are always tasty; this is unrelated to nostalgia. And the italian bread and butter is awesome- great to fill up on and then take half your meal home for later...
Posted by rmmd on 12/22/2004
I live a few blocks away. I read the reviews here, and the one negative review made me a little wary. I went ahead and ordered anyway. One order of spinach ravioli in marinara. Got here fast, 10-15 mins. Larger serving than I expected, plus a bread about 10 inches long. Not the best I've ever had, but better than the average in nyc. I'd say this is a very good value
Posted by Justshutitoff on 08/18/2004
...you may be more than a little dissapointed. The pizza is safe, especially if you ask them to make it well done. Everything else is overcooked and soggy. Ravioli come floating in a dish of greasy watery tomato sauce. There is a greasy shine to every dish. Some dishes are prepared in a way I have never seen before, and that is not a compliment. For example, the Fra Diavalo dishes are packed with onions!? The waiters are all very old and forget about you all the time. The bread makes Wonder seem kind of home made. It wouldn't be so bad at V&T if it wasn't for Cafe Taci and Pertutti around the corner. V&T happens to be closer to my house, and so lazily, I pop in there sometimes. Every single time I ask myself "why didn't you just walk the extra block and eat something you like?" Sandwiches are safe, but not better than any other pizzeria. The people are very nice, but this is a blunt, fair review. I didn't go to Columbia, so I can't factor in the nostalgia I can only assume beefs up their rating.
Posted by J-Wild on 05/09/2004
This place has be best meat lasagna there is. I can't really comment on the other menu items becuase I can't convince myself to get anything else but the lasagna because it's that good. From tasting other peoples dishes, the pizza is good as well as the veal parmasiana. The portions are terrific and it's worth every penny.
Posted by ba8alou on 04/07/2004
amazing, amazing pizza I've been coming here for 25 years and it never disappoints.
Posted by Eric on 11/28/2003
The service needs a bit of work both on eat-in and take out orders. That said the food is great and reasonably priced.
Posted by Gerard on 10/11/2003
It's VERY good. I am surprise not too many people know about it. More popular with the college crowd but your whole family will like it. The service is a little short with you but who cares? We are there for the pizza!


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31-Year-Old Defender Bayern Munich Bundesliga Full Name: Bonfim Costa
October 4, 2014 Dante News
RotoWire Fantasy Analysis
Dante recorded his fourth Bundesliga clean sheet of the season in Bayern Munich's 4-0 win over Hannover 96 on Saturday.
While he doesn't figure in the attack at all (zero shots this season), the Bayern defense has been excellent this season and Dante has been able to benefit. In addition to his four league clean sheets, he also has one in the Champions League. The only issue he has to deal with is playing time, as he's come off the bench in three of the last eight matches in all competitions.
Recent RotoWire Articles Featuring Dante
The Clean Sheets: Previewing the World Cup Semifinals
Published July 7, 2014
Can Lionel Messi keep Argentina rolling all the way to the World Cup final?
More Dante Articles View Last 30
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Dante: Past News Updates ( ▲ View most recent update )
July 6, 2014
RotoWire Fantasy Analysis
Dante is expected to start Brazil's World Cup semifinal match against Germany on Tuesday in place of Thiago Silva, who is ineligible after picking up his second yellow card of the tournament in the quarterfinal against Colombia, The Guardian reports.
If there is one team that Dante is familiar with it's Germany, who have a number of his Bayern Munich teammates on the squad, including Thomas Muller, Bastian Schweinsteiger, Philipp Lahm, Mario Gotze and Toni Kroos. That being said, he doesn't have much scoring upside and is unlikely to record a clean sheet against the strong German attack.
November 2, 2013
RotoWire Fantasy Analysis
Dante (ankle) is in the starting XI for Saturday's Bundesliga match against TSG Hoffenheim.
Dante has been battling an ankle issue for a while now and it seemed like he was going to miss Saturday's match. Not only is he available, he is starting, although it wouldn't be surprising if he didn't last the full 90 with a Champions League tilt against Viktoria Plzen coming up Tuesday.
November 1, 2013
RotoWire Fantasy Analysis
Dante has returned to training but continues to struggle with his ankle problem, Goal.com reports. "He has trained well," said manager Pep Guardiola, "although there are still little problems."
It seems that Saturday's match against TSG Hoffenheim could be too soon for Dante, who could be available for Tuesday's Champions League match against Viktoria Plzen.
October 19, 2013
RotoWire Fantasy Analysis
Dante suffered a deep cut to his left ankle during Saturday's match against Mainz, which will sideline him for 10-to-14 days.
Dante was subbed off for David Alaba before halftime and was stitched up during the break. Dante hasn't provided much fantasy value this season outside of his clean sheets, although he did record an assist during Bayern's Champions League match against Manchester City on October 2.


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Pelicans "big five" rotation an offensive force… and a defensive mess
Nov 30, 2013, 8:00 PM EDT
When people were excited to watch the Pelicans this season — I had them as my league pass team — it was with this rotation in mind: Jrue Holiday at the point, Eric Gordon at the two, Tyreke Evans at the three, with Ryan Anderson as a stretch four and Anthony Davis as their best player anchoring the middle.
Now that they are all healthy, coach Monty Williams is starting to lean on that five-some more, notes John Schuhmann at NBA.com. Williams did it midway through the first quarter against the 76ers, and Schuhmann breaks it down.
And the big five went right to work offensively, scoring 23 points on 11 possessions to end the period….
"When (Davis) runs the court, all of the attention focuses on him," Anderson said. "So he leaves an open shot for me or, if we actually get set up down at the other end, Tyreke's going to attack the rim and force a lot of attention himself. I think we just have a group of guys that really just know how to play in that lineup."
That lineup struggled in a stretch during the third quarter, but overall, scored 54 points on 38 possessions on Friday, a rate of 142 per 100, which is pretty incredible.
On the season that rotation has played 51 minutes so far and has an offensive rating of 132.4 points per 100 possessions (for comparison, Houston has the top offense in the NBA so far at 109.7 per 100). That group of five has a ridiculous true shooting percentage of 62.7.
But they are giving up 116.4 points per 100 possessions (again for comparison, the Nets have the worst defense in the NBA so far allowing 107.2 per 100). The bright side, that's still +16 per 100 possessions (and that rotation plays at a 99 possessions a game pace).
Williams told Schuhmann after the game the rotation is a work in progress.
"We try to get to that lineup, but that's not a cure-all," Williams said afterward. "It is a lineup that can cause problems. But we just have to learn how to defend and share the ball better…
"You can't just put a defensive lineup on the floor [to get better defense]," Williams said before the game. "Whoever you put on the floor has to play better defense. We're a month into it. Our guys are going to figure that out. I would like to find more minutes for that group."
Look for more of this lineup going forward, especially if they start to defend better.
- nbascreed - Dec 1, 2013 at 7:17 AM
Please stop. Just stop trying to interpret and actionalize the advanced data and stats. You really have no idea how to use them and frankly it's embarrassing to watch you flail around and try to become the "stats blogger".
You wrote an article based on a sample of 51 minutes, out of what a possible 900+??? You offered no basis in comparison to other Big 5 rotation minutes for us to contextualize against. Please stop, for your own credibility. No one is buying you as the "stats guy" and it's clear to us who have some basis in data analysis that you really have no idea how to explain your data or contextualize your findings.
- knightrider1755 - Dec 1, 2013 at 10:15 AM
I'll reserve any comments I may have until after the Knicks-Pelicans game.
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Excerpt Only This is a shortened version or summary of the article you requested. To view the complete article, please log in or create an account. Registration is Free!
Skin appearance and functionality are affected by a complex combination of factors including both genetic, i.e. intrinsic, and actinic, i.e. extrinsic or environmental. Indeed, genetic and actinic factors act together to modulate the expression of key genes involved in skin homeostasis. Intrinsic aging is genetically regulated and follows a chronological clock inside of cells, while environmental factors such as UV exposure, humidity and air pollutants are responsible for actinic aging. Together, genetic and actinic aging target important metabolic pathways in skin cells that trigger the signs of aging such as skin roughness and wrinkling.
At a molecular level, it has been demonstrated that collagen synthesis is reduced in aged skin cells and in cells damaged by UV radiation.1 Similarly, the expression of various matrix metalloproteases (MMPs), which cause the degradation of collagen fibers and other skin fibrillar components, is upregulated in aged cells as well as in cells exposed to UV, infrared radiation or excessive heat.2, 3 Furthermore, reactive oxygen species are molecular agents implicated in the deleterious effects of both intrinsic and extrinsic aging.1, 4
The skin barrier also plays important roles in skin's functioning. For instance, it prevents excessive water loss and protects against physical trauma, foreign particles such as allergens, bacteria, toxic chemicals, and also radiation. The barrier function of the skin mainly resides in the stratum corneum (SC) layer of the epidermis, where differentiated keratinocytes are embedded within a lipid matrix. With age, the ability of the barrier to repair damage from physical insults decreases.5
In an effort to develop an active to improve skin barrier repair and hydration, increase elasticity, and reduce the appearance of wrinkles, the algae extract Saccharina longicruris (S. longicruris) was investigated since algae is known for its survival abilities. Specifically, it develops thickened segments to adapt to water movements and stores compounds to survive harsh environments. Thus, to gain insight into the functionality of S. longicruris extract, the author examined its efficacy to promote keratinocyte differentiation and reverse the gene expression level of senescent human fibroblasts, described here.
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A training program for US students and teachers in sustainable community development, community organizing, and global partnerships.
Working diligently to assist talented high school students from low-income families to attend quality secondary schools in the Western Kenya region.
Strengthening the academic skills and performance of local students by providing additional English and Math training during school breaks.
Contact the Elewana Education Project using the phone number or email address below:
Please sign up for our email newsletter and receive occasional updates on Elewana.


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Bristol, Tenn. (August 23, 2008) – With three races remaining until the Chase for the NASCAR Sprint Cup, Greg Biffle and the No. 16 team were looking for a solid finish at Bristol. The 11th place finish that they left Tennessee with at the end of the night was just enough to help them keep their points position. After a long night of working on the Dish Turbo HD Ford and avoiding accidents, the team took home a solid 11th place finish and remains seventh in the point standings.
Biffle was fourth in the first practice on Friday and turned in the 14th fastest lap time in qualifying for a starting position on the outside of row seven. After the green flag dropped, Biffle fell back a little with a loose racecar and was running 14th when the first caution of the night came out on lap 97. Biffle brought the Dish Turbo HD Ford in for four tires, fuel, a wedge adjustment and an air pressure adjustment on lap 99.
The crew sent Biffle right back out in the 14th position for the restart on lap 104. He made a steady climb to the 11th position before the next caution on lap 196. Biffle let the team know that the Dish Turbo HD Ford was still just a little too loose and they made the necessary adjustments during a pit stop on lap 202. The crew picked up one position in the pits and sent Biffle out 10th for the restart on lap 206. A multi-car incident brought out the yellow and eventually the red flag on lap 217.
A few of the teams who were still on the lead lap opted to pit before green-flag racing resumed on lap 222 but Biffle stayed out and restarted eighth. A few of the drivers with fresher tires began to make their way by and Biffle found himself back in the 15th position when the next caution came out on lap 281. This time he took the opportunity to pit for four tires, fuel, a wedge adjustment and an air pressure adjustment.
Biffle restarted 12th on lap 294 which was a gain of three positions by the crew in the pits. After another pit stop on lap 345 for four fresh tires, fuel and another air pressure adjustment Biffle made his way to the 11th position. During the next stop on lap 366, however, the team opted for only right-side tires and Biffle began to lose ground on the teams with four fresh tires. He was running in the 13th position when a caution on lap 451 allowed him to make his final pit stop for four fresh tires and a wedge adjustment.
The pit crew picked up two positions in the pits as Biffle restarted 11th on lap 458. He was able to maintain the 11th position throughout the closing laps and finished alongside three of his teammates when the checkered flag dropped. Matt Kenseth took ninth, David Ragan finished 10th and Jamie McMurray took home a 12th-place finish.
"We had a decent car tonight," said Biffle. "The Dish Turbo HD Ford Fusion probably wasn't quite good enough for the win but we were able to get a solid finish and maintain our points position. We've got two good tracks ahead of us before the Chase starts and I really feel confident that this team can secure our position before we get to Richmond."
Greg Biffle and the 3M/Dish Network team are currently seventh in the point standings. They are 625 points out of the lead currently held by Kyle Busch and 141 points ahead of David Ragan in the 13th position. They are only 29 points behind Tony Stewart in the sixth position. The team will return to the track on Sunday, August 31st at Auto Club Speedway.
About Roush Fenway Racing
Roush Fenway Racing is NASCAR's largest team operating 13 motorsports teams. Five in the NASCAR Sprint Cup Series with drivers Matt Kenseth, Jamie McMurray, Greg Biffle, Carl Edwards and David Ragan; four in the Nationwide Series with Kenseth, Biffle, Edwards, McMurray, Ragan, Erik Darnell and Colin Braun; and three in the Craftsman Truck Series with Darnell, Braun, Kvapil, John Wes Townley and Bobby East; and one in the ARCA RE/MAX Series with Ricky Stenhouse Jr.


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There's little to write about regarding the scudetto race of the Serie A now. A commanding 3-0 win by AC Milan over Inter has seemingly decided that this season we will have a new champion. The scudetto is now for … Continue reading
Milan remain on top of Serie A yet their hold has become more tenuous than ever with city rivals Inter lurking just two points behind. The Rossoneri have some of the league's most talented individuals such as Robinho, Zlatan Ibrahimovic … Continue reading
When Francesco Guidolin left Parma to manage Udinese, I was disappointed. Guidolin had united a set of strong individuals, managing Parma all the way up to eighth in the table last season. Udinese finished 15th this past season, yet Guidolin … Continue reading
It had been a long time that the Serie A wasn't as interesting as it is now. The vacuum left by Inter's downfall was filled with a tempestuous AC Milan which is now beginning to slow down. Along with AC … Continue reading
During the winter break Serie A fans got to contemplate many things. How will Cassano do at AC Milan? What new signings will we see in the January transfer window? And how will Leonardo do at Inter Milan? The last … Continue reading
2010 was a bad year for Italian football. I tried to think of the positives, but very few came to mind. A disastrous World Cup in South Africa, a bad showing in the Europa League, and only a Champions League … Continue reading
Milan defeated fallen giants Juventus 3-0 in a match with no consequence to the Serie A title race yet it served as the proper farewell for coach Leonardo who managed to do well despite the lack of depth in the … Continue reading
It was recently confirmed that AC Milan and the Brazilian coach Leonardo will part, while in the press conference Leonardo was calm and seemed happy with his decision, it's strange to see the young manager leave so quickly. AC Milan have … Continue reading
It's been a perculiar, unpredictable season for Milan as the side have endured great levels of torment from humiliating defeats to the likes of Inter and Manchester United, and they have found themselves looking desperately blunt on other occasions, often … Continue reading
The most anticipated match-up of the weekend is the AS Roma-AC Milan contest to decide which club can challenge Inter for the top spot in Serie A. While the loser still has an outside shot at the scudetto, an Inter … Continue reading
Fans of AC Milan have suffered through a bad four weeks, beginning by losing to short-handed rival Inter and most recently suffering a devastating defeat in their Champions League match versus Manchester United. This comes the same week that Milan … Continue reading
With the current crop of players, Milan were unlikely to win the Champions League as the Rossoneri have no depth, are short on alternatives in key positions and have an inexperienced Coach in Leonardo. The Brazilian Coach has been decent overall working to … Continue reading
A Halloween weekend for the 11th matchday saw tricks and treats for various clubs, players and managers. In honor of the holiday, we will take a look at those who got their candy this weekend and those who got toilet … Continue reading
The Top 6 Keep This Week Interesting Inter, Sampdoria, Juventus, Palermo, Fiorentina and AC Milan all won this weekend to raise the stakes for the mid-week matches: Genoa v. Fiorentina, Napoli v. AC Milan, Juventus v. Sampdoria, and Inter V. … Continue reading
I think it is fair to say that AC Milan's start to the season has been less than impressive to say the least. However, victory over Roma at the weekend propelled them into the top half of the table and … Continue reading


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On Friday night at LA's Hyde nightclub, Lindsay and Paris had it out. Hilton's representative Elliot Mintz explains, "Paris was having a conversation with a couple of friends. Lindsay approached her table and at that moment Paris felt she was being interrupted and didn't wish to speak to Lindsay…A couple of words were exchanged and Lindsay went back to her table."
Sources say the root of the problem is that Lindsay name-dropped Paris during publicity of Just My Luck. Others suggest it has to do with Lindsay's recent succession of boyfriends, ie: Stavros and Paris Latsis or the recent charity event where Lindsay catwalked with Paris' enemy Nicole Richie. But we'd like to think it all comes back to Aaron Carter.