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A method of relieving erectile impotence in a human male. The method comprises administering to the male an erectile impotence relieving amount of a compound selected from the group consisting of U.K. 52,046, Amlodipine, Doxazosin and the pharmaceutically acceptable acid addition salts thereof.
1. A method of relieving erectile impotence in a human male comprising administering to said male an erectile impotence relieving amount of the compound U.K.-52,046 and the pharmaceutically acceptable acid addition salts thereof.
2. The method as recited in claim 1 wherein the compound is the mesylate salt.
3. The method as recited in claim 1 wherein the compound is administered by injection.
4. The method as recited in claim 1 wherein the compound is administered transdermally.
5. The method as recited in claim 2 wherein a single dosage is about 0.1 μg to about 25 μg.
6. The method as recited in claim 3 wherein a single dosage is about 10 μg to about 100 mg.
7. The method as recited in claim 1 wherein the compound is the methane sulfonate salt of U.K. 52,046.
This is a continuation of application Ser. No. 07/531,494 filed on May 31, 1990, abandoned.
The field of art to which this invention pertains is methods of treating male erectile impotence and more particularly the use of erection enhancing compounds to treat male erectile impotence.
Impotence is the inability to obtain and sustain an erection sufficient for intercourse. The penis becomes erect when certain tissues (in particular, the corpora cavernosa) in the central portion of the penis becomes engorged with blood thereby causing them to become less flaccid, and in turn causing an erection. It is estimated that 10-12 million American men between the ages of 18 and 75 suffer from chronic impotence with the great majority being over the age of 55.
Impotence results from psychologic disturbances (psychogenic), from physiologic abnormalities (organic) or from a combination of both. Typically, multiple factors are responsible for impotence.
The major causes of organic impotence are vascular abnormalities, neurologic deficiencies and drug treatment side effects. The primary vascular causes of impotence are arterial insufficiency, which prevents the penis from filling with blood, and venous abnormalities that prevent the retention of blood in the penis during the erectile process. Arterial insufficiency is primarily due to atherosclerosis and has been found to be exacerbated by smoking. A less frequent and somewhat unlikely vascular cause of impotence is priapism, prolonged painful erection, which can cause hypoxia and death of penile tissue.
The search for impotence treatment methods has included external devices for example, tourniquets (see U.S. Pat. No. 2,818,855). In addition penile implants, such as hinged or solids rods and inflatable, spring driven or hydraulic models, have been used for some time. The administration of erection effecting and enhancing drugs is taught in U.S. Pat. No. 4,127,118. That patent teaches a method of treating male impotence by injecting into the penis an appropriate vasodilator, in particular, an adrenergic blocking agent or a smooth muscle relaxant to effect and enhance an erection. More recently U.S. Pat. No. 4,801,587 teaches the application of an ointment to relieve impotence. The ointment consists of the vasodilators papaverine, hydralazine, sodium nitroprusside, phenoxybenzamine, or phentolamine and a carrier to assist absorption of the primary agent through the skin. In addition, Yohimbine, an alpha adrenergic antagonist is currently marketed with the suggestion that it may be efficacious in treating psychogenic impotence.
Although the injection of such agents as papaverine into the corpora cavernosa has proven effective, typically large doses 8 to 32 mg are required, resulting in undesired side effects such as pain, priapism and tissue fibrosis. The other impotence relieving agents also have one or more of the above problems when administered intracavernosally.
Thus, there is a continuing search in this field of art for improved methods for relieving male erectile impotence.
The invention is directed to a method of relieving erectile impotence in a human male. The method comprises administering to the male an erectile impotence relieving amount of a compound selected from the group consisting of U.K. 52,046, Amlodipine, Doxazosin and the pharmaceutically acceptable acid addition salts thereof.
Other features and advantages will be apparent from the specification and claims.
Doxazosin, which has the chemical structure: ##STR1## and its pharmaceutically acceptable acid addition salts are described in commonly assigned U.S. Pat. No. 4,188,390, entitled "Antihypertensive 4-Amino-2-[4(1,4-Benzodioxan-2-carbonyl)Piperazin-1-yl or Homopiperazin-1-yl]Quinazolines", the disclosure of which is hereby incorporated by reference. U.K.-52,046, which has the chemical structure ##STR2## and its pharmaceutically acceptable acid addition salts are described in commonly assigned U.S. Pat. No. 4,686,228, entitled "Quinoline Therapeutic Agents", the disclosure of which is hereby incorporated by reference.
Amlodipine, which has the chemical structure ##STR3## and its pharmaceutically acceptable acid addition salts are described in commonly assigned U.S. Pat. No. 4,572,909, entitled "2-(Secondary Aminoalkoxymethyl)Dihydropyridine Derivatives as Anti-Ischaemic And Antihypertensive Agents", the disclosure of which is hereby incorporated by reference.
Although the generic names Doxazosin, Amlodipine and U.K. 52,046 represent the free base, the present invention is also meant to embrace their pharmaceutically acceptable acid addition salts, such as hydrochloride, hydrobromide, hydroiodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, acetate, lactate, citrate, acid citrate, tartrate, bitartrate, salicylate, succinate, maleate, gluconate, methane sulfate, ethane sulfate, methane sulfonate (mesylate), benzenesulfonate (besylate), toluene sulfonate and p-toluenesulfonate salts. However preferred are the mesylate or besylate salts.
Any method of administration of the above compounds found effective in relieving male erectile impotence may be used. Preferably the administration is parenteral (e.g. injection, air gun) or transdermal (e.g. iontophoresis, passive transport) as these methods direct the compound to the critical tissues.
For purposes of parenteral administration, (e.g. intracavernosal) solutions of these particular compounds in sesame or peanut oil or in aqueous propylene glycol may be employed, as well as sterile aqueous solutions of the corresponding water soluble acid addition salts previously enumerated. Such aqueous solutions should be suitably buffered if necessary. These particular aqueous solutions are especially suitable for intracavernosal injection purposes. In this connection, the sterile aqueous media employed are readily obtained by standard techniques well known to those skilled in the art. For instance, distilled water is ordinarily used as the liquid diluent and the final preparation is passed through a suitable bacterial filter such as a sintered glass filter or a diatomaceous-earth or unglazed porcelain filter. Preferred filters of this type include the Berkefeld, the Chamberland and the Asbestos Disk-Metal Seitz filter, wherein the fluid is sucked into a sterile container with the aid of a suction pump. Needless to say, the necessary steps should be taken throughout the preparation of these injectable solutions to insure that the final products are obtained in a sterile condition. The injection can be made by needle or air gun. Typically the injection is made into the corpus cavernosum although any injection that is effective in relieving impotences may be used.
Any amount of the above described compounds when administered by injection that is effective in relieving male erectile impotence may be used. Because the compounds are vasodilators the drugs can reduce the blood pressure resulting in systemic cardiovascular effects (e.g. fainting). Thus, preferably the amount is below that amount which is the threshold limit for a significant systemic cardiovascular effect.
The frequency of delivery, of the amounts described below, relates to the frequency of impotence relief. Typically the compounds are administered just prior to the desire to obtain and sustain an erection. However as previously stated the total amount delivered is preferably below the threshold limit for significant systemic cardiovascular effects.
Preferably about 0.1 μg to about 25 μg U.K.-52,046 is used in a single dose. Preferably about 0.125 mg to about 5 mg Doxazosin is used in a single dose. Preferably about 0.125 mg to about 10 mg Amlodipine is used in a single dose.
Below the lower limit the compounds are not effective and above the upper limit significant systemic cardiovascular effects may occur.
The above described compounds can also be administered transdermally. For purposes of transdermal administration, the dosage from of the particular compound may include, by way of example, solutions, lotions, ointments, creams, gels, suppositories, rate-limiting sustained release formulations and devices therefor. Such dosage forms comprise the particular compound and may include ethanol, water, penetration enhancer and inert carriers such as gel-producing materials, mineral oil, emulsifying agents, benzyl alcohol and the like. Specific transdermal flux enhancing compositions are disclosed in commonly assigned co-pending U.S. patent application Ser. No. 925,641, the teachings of which are incorporated by reference. That specification teaches a transdermal flux composition comprising a pharmacologically active compound or a prodrug thereof, an aqueous ethanol solvent containing from 15% to 75% ethanol by volume and cis-olefin compounds such as oleic acid.
For transdermal administration the compounds may, for example, simply be applied directly to the penis. In another method of transdermal application the compounds may be delivered transdermally utilizing iontophoresis. In iontophoresis a drug is transported from a solution (disposed against the skin) across the dermal barrier by the application of a current across the solution and skin.
Any amount of the above described compounds when administered transdermally that is effective in relieving male erectile impotence may be used.
Typically the same amounts are preferably delivered to the critical tissues as are delivered by injection, however the amounts applied transdermally are typically greater because of the low effectiveness of transdermal administration for delivery to the critical tissues. As with injection, the amounts delivered are preferably below the threshold limit for significant systemic cardiovascular effects. The frequency of delivery is the same as described for injection. The amounts detailed below are for passive transdermal delivery. It is believed that for iontophoretic delivery the ranges would be reduced by a factor of 10 based on the greater efficiency of iontophoretic delivery.
Thus, preferably about 100 μg to about 100 mg U.K.-52,046 is used in a single dose. Preferably about 0.5 mg to about 500 mg Doxazosin is used in a single dose. Preferably about 20 mg to about 20 g Amlodipine is used in a single dose.
Seventeen mature adult male monkeys (age unknown) either Cercopithecus aethiops (green monkey) or Macaca fasciculata (cynomologous) weight range 4.7 to 7.1 kg were used. Animals were anaesthetised with diazepam (2.5 mg), ketamine chloride (20 μg/kg i.m. supplemented as appropriate) and given the appropriate drug dissolved in saline intracavernosally (0.3 ml). In a separate series of experiments to determine threshold effects, varying volumes of i.v. injectable solution were injected intracavernosally. Animals were placed supine, the penis stretched out and a rubber band placed around the root of the base as a tourniquet kept in place for three minutes after the injection. The solution was injected through a 27G needle into one of the corpus cavernosa and 5, 10, 25, 30, 60 and 180 minutes later tumescence (increase in volume) and rigidity of the penis was estimated visually and by palpitation. To determine the threshold effect using the injectable solution a series of animals were used covering an appropriate dose range, e.g., U.K. 52,046 (0.05 to 0.3 μg). The antidote/reversal experiments involved intracavemosal administration of noradrenaline (10 μg) phenylephrine (10 μg) or clonidine (15 μg).
Table 1 below details the comparative effect of U.K.-52,046, Doxazosin, Amlodipine, Papaverine and Phentolamine by injection to monkeys as described in Example 1 above. Surprisingly U.K.-52,046, Doxazosin, and Amlodipine all were effective for causing Tumescence and Rigidity at significantly lower doses than either Phentolamine or Papaverine. In fact, U.K.-52,046 was effective at doses 1000 times lower than for Phentolamine or Papaverine.
TABLE 1__________________________________________________________________________Comparative Effects In Monkeys Threshold TimeDrug Dose Tumescence Rigidity Course Reversible__________________________________________________________________________U.K.-52,046 0.1 μg +++ +++ S SDoxazosin 100 μg ++ + S SPapaverine 6.0 mg ++ ++ S SAmlodipine 500 μg ++ ++ X XPhentolamine 1.5 mg ++ ++ S S__________________________________________________________________________ 0 = no effect + = minimal effect ++ = good effect +++ = full effect S = satisfactory X = unsatisfactory
Sheets of excised human skin cut to about 350 μm thickness were mounted between two halves of a diffusion cell (Side-by-Side, Crown Glass) with the stratum corneium side toward the donor compartment which contained 3 ml of radiolabelled drug in the appropriate vehicle. The receiver compartment contained 3 ml of 40% (v/v) ethanol in an acetate buffer. Both compartments were stirred with a magnetic stirrer and maintained at 32� C.
Samples were removed periodically from the receiver side of the diffusion cell, mixed with scintillation cocktail (Ecolume, ICN Radiochemicals) and counted for 10 minutes in a liquid scintillation counter (Tri-Carb 2000CA, Packard). Following an initial lag phase of several hours, the amount of radiolabeled drug appearing in the receiver side was linear with time for the duration of the experiment (routinely 24-48 hours). From a linear least squares analysis of these data the rate of appearance of UK-52,046 in the receiver chamber was determined. This value, when divided by the specific radioactivity of the drug in the donor solution and the area of exposed skin (1 cm2), yielded the flux (μg/cm2 /hr). Samples removed from the donor chamber at the beginning and end of the experiment contained, within error, the same amount of UK-52,046. Thus, constant concentration of the permeant was maintained on the donor side throughout the experiment. Values for the delivery of UK-52,046 reflect total radioactivity; no measure of the amount of intact drug was made.
Table 2 below details the effective in vitro transport of UK-62,046 transdermally according to the procedure described in Example 2.
TABLE 2______________________________________Transport of U.K.-52,046 across human skin from asolution containing 8 mg/ml drug as the mesylate saltin 40% (v/v) ethanol:buffer (pH 4.5) FluxSkin Type (μg/cm2 /h) n______________________________________Thigh 3.25 1Thigh 3.53 1Thigh 1.69 1Thigh 0.95 3 x = 1.98 � 0.96Penis 0.63 2______________________________________
Table 3 expands on Table 2 above by using a pretreatment to enhance the effective transdermal in vitro transport of UK-52,046. The procedure used was according to Example 2.
TABLE 3______________________________________In vitro transport of UK-52,046 across humancadaver skin as a function of various pre-treatments.The vehicle was 40% (v/v) ethanol:buffer (pH 4.5).Treatment2 Flux1 (μg/cm2 /h)______________________________________No pre-treatment 0.95Vehicle, no Oleic 0.22Vehicle + 0.25% 1.26Oleic Acid100% Oleic Acid 2.45______________________________________ 1 All values are the mean of three replicates. 2 Treatment was for 3 hours prior to the diffusion study. A concentration of 8 mg/ml UK52,046 was employed.
This invention provides methods of treating male erectile impotence by the administration of certain compounds to effect and enhance an erection. These compounds are effective at very low dosages and thus reduce the undesired side effects of other compounds.
It should be understood that the invention is not limited to the particular embodiments shown and described herein, but that various changes and modifications may be made without department from the spirit and scope of this novel concept as defined by the following claims.
Patent Citations
Non-Patent Citations
Referenced by
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On December 12th, the Los Angeles Dodgers tendered contracts to a trio of arbitration eligible players: Clayton Kershaw, Andre Ethier, and James Loney. However, they elected to not tender a contract to Hong Chih Kuo. The other two arbitration eligible players, Matt Kemp and Tony Gwynn Jr., were signed to extensions earlier.
According to MLB Trade Rumors, the projected arbitration salaries for the quartet were $10.7 million for Ethier, $8.4 million for Kershaw, $6.5 million for Loney, and $2.5 million for Kuo.
Ned Colletti made the right decision on all four, as Ethier, Kershaw, and Loney all project to be worth more than their arbitration numbers, and Kuo's injury history and anxiety disorder are reason enough to not want to pay a premium.

subset: commoncrawl


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Our ProductsListed below is a catalog of concrete chemicals. Click on picture of container to find detailed information on each of our products. Click on the "Product Categories" to view items grouped by their function. Included in each product description is a link to its Technical Data Sheet (TDS), Material Safety Data Sheet (MSDS), and if applicable; Application Guide, Color Chart, and/or Photo Gallery.
Acid Staining Sprayer »
Sprayer resists acid stain corrosion & sprays a fine mist to prevent color lines on concrete.
Acid Stains chemically react with minerals to highlight the natural variations in concrete.
Applicators »
Clemons has the right applicator for your sealing needs. Choose from 9" fixed or adjustable (up
Clear Cure »
Water-based clear curing compound. Conforms to ASTM C309, Type I Class B and AASHTO M148.
CRACK FILLER for Broom Swept Concrete »
Crack repair in a quart squeeze bottle that dries to match plain broom swept concrete.
CRACK FILLER for Exposed Aggregate Concrete »
Crack repair in a quart squeeze bottle that dries to match exposed aggregate concrete.


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I have ulcer, a super big and painful ulcer now. (oucchh…!) I can't eat anything that is hard to bite, not even normal soft bread. My ulcer has made me feel pain in my mouth and neck too. I start having this ulcer since Saturday but it is getting worse because on Sunday night, I ate BBQ chicken, spicy stir-fried clams, a truly good lesson for me.
So I have been eating soft food these few days. Tonight, if nothing turns well and I am still getting the ulcer, I will seek for professional help the next morning.
Okay, enough for my ulcer speech.
I want to introduce you what we eat for dinner today. We normally have lots of vegetables, some or no meat and dessert. Since I am still having this ulcer sticks inside my mouth, I want to get rid of it with some garlic. We will have lots of garlic! All of these garlics will go inside my wok!
Then, I will just do a simple stir-fry, with greens of course. The rest are just normal stuffs like marmite, pork floss and fermented bean curd.
Our dinner is not complete without fruit juice. We have fruit juice every day. Yes and these fruits will go into this to make juice. So tonight, we have 3 apples, 2 oranges and celery; it is super quenching and sweet!
Then of course, a dinner is not complete without dessert, we normally have ice-cream, or peanut (not this week) or just anything. Ben & Jerry ice-cream is great, especially this one with some liquor (liqueur), a grown-up ice-cream, not suitable for children.


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the zippers are not good , all broken after just a few months
The bag is use to carry swim wear to the pool and the main zipper after a few months was broken , i replaced as it was embroider and did't want to trough away the bag and now all the other zippers are broken also..i guess the ones with the black zipper will be better
mariagabriela m.
weston, FL
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I returned it...
I loved this bag because it was different. I ended up sending it back after a month. The gold zipper was breaking on all pockets. Was issued a credit for a new bag.
Stacey V.
Cleveland, OH
Really cool and strong. My son loves it and my other boys want to exchange the Tyr backpacks for one of this. So far we love it!
Fatima M.
Mission Viejo, CA
Everyone wants one now!
I baught this for my daughter. Her team colors are black and gold, so it was perfect! She brought it in to the locker room, and all the older teenagers told her "You know everyone is getting that bag now!" The Gold is very shimmery...gorgeous! The only issue it seems to have are the zippers are a bit stiff. I am sure this will go away after some use.
Washington State
Great swim backpack !
I bought 2 of them for my daughters'. First of all they look awesome, great space, haven't really gone to a meet yet with the backpacks, but definitely fits a lot of stuff (all needed for a meet). The only drawback are the zippers, they have to be aligned together well in order to zip it close. But now my girls have learnt how to & hopefully will work well. I guess Speedo should do something to improvise on that.
Prachi N.
team speedo USA Pro Backpack
My daughter picked this bag because, I think, of the name. After a month the coarse grain zipper starts to unravel and the teeth start to drop off bit by bit. The coarse zipper doesn't work very well for the bag's angular soft and flexible corners. After two months, the zipper was missing so many teeth, it wouldn't zip up anymore.Fortunately, swimoutlet replaces our bag. I am watching this replacement closely to see if the same thing will happen.
burlingame, CA
Zipper broke off after 1 month
My daughter loved the look of this bag, especially with her name embroidered in matching gold thread, but after 1 month we found almost 2 inches of the zipper completely missing from the bag. The zipper does appear to be plastic and seems to be a common problem with the bag. My daughter's last Speedo Pro Backback lasted over 2 years so we know they are generally very durable,but I can't recommend this one. Thankfully we were able to return it!
Great looking but zippers weak
The backpack is awesome, the look is cool, and my daughter loved it. Unfortunately, the zippers started to break after about a month or less. Oddly, we also bought the blue version for my other daughter and that one is still going strong. Fortunately, Swim Outlet has the best customer service in the business and quickly replaced the backpack for us. Still, hope Speedo improves its product in the future. Thanks Swim Outlet.
Danville, CA
Beautiful bag!
my daughter LOVES this bag. it has just the right amount of bling. it is extremely large and can accommodate all of her equipment with ease. she was using the smaller speedo bag and then the mesh speedo for years but all of the equipment she now carries (buoy, snorkle, paddles, etc) made it too difficult to fit without going larger. she has received numerous compliments from her teammates on her new bag.
Stephanie K.
Ft. Lauderdale, FL
Got this bag for my 10 yr old daughter. I'd seen a review about the plastic zipper not being great, but it's perfectly FINE!! My daughter can open and close with ease, and the size & pockets make the bag easy for swim and anything else. She's already taken it to sleep overs AND carried her swim stuff too, with no issues. This is a bag she will have for years to come!!
Alexandria, VA
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The world's leading swimwear brand, Speedo is passionate about life in and around the water. The brand's heritage of innovation derives from its leadership in competitive swimming, where more Olympic Gold Medals have been won in Speedo than any other brand. Using the pioneering technology created for the planet's top swimmers, Speedo brings performance, comfort and style to all who enter the water, whether racing for a record finish, swimming laps for better health or making memories at the beach.
Our Performance Collection includes the competition and training suits that remain the number one choice of the world's fastest swimmers; our Fitness and Active Recreation Collections feature men's and women's swimwear, men's water shorts, and kids swimwear in fashion-forward styles that are designed to perform. And with Speedo's expanded range of Footwear, Packs, Aquatic Fitness and Swim Training Equipment, our Accessories Collection is unmatched in performance, fit and feel. No matter why you dive in – training, fitness or fun – those moments in the water are always better with Speedo.


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FanZoner Tim Ward knows that Tony Pulis is a hard act to follow at Stoke but has been impressed by the start Mark Hughes has made at the Brit.
Back in March I wrote about how I thought that come the end of the season I wouldn't be surprised if Tony Pulis parted ways with Stoke City. Turns out that I was absolutely spot-on, with the Welshman leaving the Britannia Stadium after seven very successful years "by mutual consent".
Pulis' job at the Potters in his second spell shouldn't be understated. He took the club from the basement of the Championship to an FA Cup final and European football and made them an established Premier League Team. All that was unthinkable seven years ago, with the club looking at possible relegation to League One.
But last season there was a feeling that things were set to change. The club had a fantastic first half of the season, sitting in eighth with one of the best defences in Europe. But after Christmas it all went horribly wrong with the club dropping down the table. Quiet rumblings of discontent from the fans grew louder.
It seems that at the end of the season, Pulis, chairman Peter Coates and the board sat down and it was decided that it was better for everyone if they went their separate ways. Pulis will go down as one of, if not the best Stoke manager of all time, and for that he will always be thanked in the Potteries.
In March I also said that the job would be a good prospect for any manager. The candidate list featured some high and some less-so-high profile names and although I personally didn't have Mark Hughes as my first choice, his appointment looks a potentially shrewd piece of business by Peter Coates. Hughes' style isn't very different from Pulis' but enough of a change for it to be noticed and Hughes must also be keen to restore his reputation following his departure from QPR.
Although still early days, the signs have been encouraging so far. Jermaine Pennant might not be a leading winger in the Premier League, but his re-signing a contract after being released by Pulis does see us have at least one recognised right-winger on the books.
Two other signings, both from Europe, have also excited the fans. Dutch international full-back Erik Pieters arrived from PSV Eindhoven followed shortly afterwards by 21-year-old Marc Muniesa from Barcelona - a defender who was a member of the Spain Under-21 squad which won this summer's European Championship.
The 2013-2014 season is getting ever closer with several clubs entering new eras like Manchester United, Everton and Chelsea, and Stoke City are no different - it will certainly be interesting.
By Tim Ward, FanZone's Stoke blogger. Follow him on Twitter here and don't forget to follow @FanZone too!


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Click below to download MP3s from the soundtrack to FIT – songs from and inspired by the film, all recorded and kindly donated by Rikki Beadle-Blair. Enjoy!
♫ I Am U (MP3)
♫ The Beat Is Strong (MP3)
♫ To Be Or Not To Be (MP3)
♫ Fly With Me (MP3)
To download, click on the link below the image that refers to your screen size. This will bring up a larger version, which you can then right click and 'save as background', (or 'save to desktop' in Firefox.). If you're not sure, download the largest - 1280 x 1024.
Have you watched FIT or seen the trailers? Click here to tell us what you think.
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Eleanor Roosevelt was my Plan 'foster parent'
9 December 2010: A former Plan-sponsored child has taken part in a BBC documentary about her Second World War correspondence with her famous 'foster parent' - America's First Lady, Eleanor Roosevelt.
Paulette Le Mescam, who is now 78 and lives on the Channel Island of Guernsey, used to write to the White House every week after she was evacuated from the island to Moseley Hall in Cheshire, UK.
She was 7 years old, and one of 1,200 children rescued from Guernsey in 1940, just hours before the island was occupied.
Enrolled on the 'Foster Parent Plan for War Children' scheme (later to be renamed Plan), each child was allocated an American sponsor who would send them letters and parcels each month. Her 'foster parent' turned out to be Eleanor Roosevelt - the wife of the then President, Franklin D. Roosevelt.
White House letters
Paulette sent letters to the White House about her life, as well as drawings and pictures. In return, Eleanor Roosevelt told Paulette about life in the White House and sent presents of clothes, chocolate and food parcels.
Paulette says: "I used to get lots of presents from Mrs. Roosevelt and the President - there was a lovely red dress and things like Lux soap which had a beautiful smell."
Sadly, just one of Eleanor Roosevelt's original letters remains in Pauline's possession, in which she explains how impressed she is that Paulette is learning shorthand, describing it as 'a splendid thing to know and one can almost always obtain work at it'.
Heart-warming discovery
However, while researching the story, the BBC team discovered that The Roosevelt Archive in America has kept copies of all the letters and drawings Paulette wrote to America's First Lady.
The pictures include a drawing of an owl with the words 'Why don't you copy this wise old bird?' written underneath - innocent words of advice from 7-year-old Paulette to Mrs. Roosevelt and her husband during one of the most turbulent times in world history.
In the documentary, Paulette returns to Moseley Hall for the first time in 65 years, where she is presented with the letters and pictures she sent to Eleanor Roosevelt over 70 years ago.
Watch the 'Inside Out' documentary on the BBC iplayer website (available until Monday 13 December).
View a slideshow on the BBC website.
Learn about Plan's history.


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Lurie Cancer Center Member
Melissa Simon, MD, MPH
Academic Title:
Associate Professor, Obstetrics and Gynecology; Feinberg School of Medicine
Member of:
Women's Cancer, Cancer Control & Survivorship
View Publications Listing
Cancer-Focused Research:
Dr. Simon's primary research interests are aimed at eliminating health disparities among low income, medically underserved women across the lifespan. Integrating health services research with social epidemiologic models, Dr. Simon's research focuses on interventions (such as patient navigation and community health outreach workers) that aim to reduce and eliminate such disparities. Within this context, Dr. Simon prefers to leverage culture and community to achieve these goals and thereby integrates community based participatory research framework into her work. Dr. Simon leads the NCI Biospecimen Management Program (BMAP) for Region 5 which is a multi-site transdisciplinary partnership that aims to increase collaborative biospecimen research and improve minority and medically underserved populations participation and retention in biospecimen and clinical trial research. Dr. Simon also co-leads the NCI minority serving institution-comprehensive cancer center P20 center grant that unites Northeastern Illinois University with the RHLCCC through social science research to reduce cancer disparities and through improving the pipeline of minority students and students interested in health disparities research.
More about Dr. Simon's research
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3:31 am
Tue July 9, 2013
Barnes & Noble CEO William Lynch Resigns
By editor
Originally published on Tue July 9, 2013 5:01 am
Lynch's exit comes just two weeks after the bookseller announced it was shelving its goal of becoming a player in the tablet business. Lynch has a tech background, and as CEO focused his attention on the Nook digital business. But the quarter that just ended showed huge losses for the digital devices.


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Dog Days
Dog Days is a program in which faculty and staff bring their dogs to campus to interact with students. It is an opportunity for students who miss their dogs (and home in general) to play with other dogs while socializing with faculty and staff. It's a great time to relax and to see the more human (or animal?) side of SU's faculty and staff.
Dog Days are held every Tuesday afternoon in September, weather depending.
If you have a friendly dog or puppy who is up to date with shots and you would like to participate, please contact Cindy Moyer at 372-4751 to register.


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Mahindra Bolero
6.34 – 8.20 Lac
Ex-Showroom price
It's the price of the car exclusive of duties, taxes, depot charges, and insurance. To get on-road price, click on 'get onroad price' button below.
EMI 12,271/mo (calculate)
- Updated design and styling as compared to previous generation Bolero.
- Well equipped with safety and entertainment features.
- Fuel efficient.
- Diesel engine feels tad underpowered at higher RPMs.
- Suspension set up needs work.
- Seating is uncomfortable.
Mahindra Bolero Variants
Mahindra Bolero DI BS IIIDiesel, 15.96 kmpl – Full Specs6.34 LacEx-Showroom price Get on Road Price
If you always believed that sports utility vehicles are all about their robust and sturdy appearance, and not necessarily about comfort and...
Mahindra Bolero EX NON ACDiesel, 15.96 kmpl – Full Specs6.56 LacEx-Showroom price Get on Road Price
When it comes to the SUVs in the Indian market, The Bolero has undoubtedly been able to give them a tough competition. Most of the sports...
Mahindra Bolero PlusDiesel, 15.96 kmpl – Full Specs6.60 LacEx-Showroom price Get on Road Price
Mahindra Bolero has been synonymous with luxury SUVs in India. There is a common perception among Indian car owners that SUVs are popular only...
Mahindra Bolero DI 4WD BS IIIDiesel, 15.96 kmpl – Full Specs6.61 LacEx-Showroom price Get on Road Price
Mahindra Bolero DI 4WD BS III is a great addition to the Bolero series. This sports utility vehicle breaks the misconceptions regarding SUVs....
Mahindra Bolero EXDiesel, 15.96 kmpl – Full Specs6.97 LacEx-Showroom price Get on Road Price
Mahindra Bolero is a top name in the SUV vehicle market in India. Although its models still sport a bulky traditional design, the Bolero...
Mahindra Bolero Plus AC BS IIIDiesel, 15.96 kmpl – Full Specs6.99 LacEx-Showroom price Get on Road Price
The Mahindra Bolero Plus AC BS III Diesel is one of the latest models from Mahindra & Mahindra – one of the top makers of automobiles...
Mahindra Bolero SLE BS IIIDiesel, 15.96 kmpl – Full Specs7.17 LacEx-Showroom price Get on Road Price
The Mahindra Bolero SLE BS III Diesel is one of the latest models from Mahindra & Mahindra, one of the best automobile manufacturers today...
Mahindra Bolero Plus BS4Diesel, 15.96 kmpl – Full Specs7.33 LacEx-Showroom price Get on Road Price
The Mahindra Bolero Plus BS4 Diesel comes from Mahindra & Mahindra, one of the biggest auto manufacturers in India at the moment.This car is...
Mahindra Bolero SLEDiesel, 15.96 kmpl – Full Specs7.37 LacEx-Showroom price Get on Road Price
The Mahindra Bolero line of SUVs has found loyal buyers among all segments and demographics of the Indian society. The Mahindra Bolero SLE...
Mahindra Bolero SLX BS IIIDiesel, 15.96 kmpl – Full Specs7.69 LacEx-Showroom price Get on Road Price
If you desire to explore the untraveled through ambiguous roads taking up challenges with pride, then your companion is Mahindra and Mahindra...
Mahindra Bolero ZLX BS IIIDiesel, 15.96 kmpl – Full Specs7.85 LacEx-Showroom price Get on Road Price
The new Bolero ZLX deliberated with distinctive features will pump in zeal of superlative driving. Designed from the Mahindra and Mahindra...
Mahindra Bolero SLXDiesel, 15.96 kmpl – Full Specs7.89 LacEx-Showroom price Get on Road Price
You will be proud to flaunt the distinctive, tough yet classy look of Mahindra Bolero SLX Diesel a classic variant of Mahindra Bolero.
Mahindra Bolero ZLXDiesel, 15.96 kmpl – Full Specs8.05 LacEx-Showroom price Get on Road Price
Powered by a 2523 cc diesel engine, the Mahindra Bolero ZLX Diesel is the best MUV in India. Mahindra recently upgraded this model of Bolero...
Mahindra Bolero Special Edition (ABS)Diesel, 15.96 kmpl – Full Specs8.20 LacEx-Showroom price Get on Road Price
A child of Mahindra & Mahindra is a special diesel edition ready to push all the competitive SUV in the market and to create some time...
Recently I test derived Mahindra Bolero and found it very much fun loving to drive as controls were very simple and easy to access and operate especially the levers around the steering. All though I found some difficulties while parking this MPV but I can manage if I get used to the size. Finally...
durable SUV
Reviewed By: KRISHNA GUPTA on 7 july 2015
I would totally agree with what Deepak has said. Mahindra has used very cheap plastics in Bolero which makes it very unpleasing for the passengers. Moreover the seats are not comfortable and do not offer enough thigh support. You could see cost cutting at very corner of the car. It has a good mil... Read More »
perfect rider
Reviewed By: Bharat Upadhyay on 6 july 2015
I bought this vehicle for taxi purpose. As a taxi this vehicle is very economical with less maintenance required, good fuel economy. The bumper is made up of steel, till now I have not spent a single penny on denting. The suspension of this car is quite stiff, so it becomes very uncomfortable whe... Read More »
affordable SUV
Reviewed By: Deepak Chaurasiya on 5 july 2015
I have purchased bolero zlx last month. In fact i replaced the old one. The new front is good looking and I like the new interior but could have made bit better. There are large uneven gaps in the interior and plastics are very cheap. But i guess I could not ask for a better 2.5 litre , 7 seater ... Read More »
A powerful beast of the road
Reviewed By: Ankit Tayagi on 4 july 2015
I have purchased bolero two months back. In fact, i replaced the old one. The new front is good looking and i like the new interior but could have made bit better. There are large uneven gaps in the interior and plastics are very cheap. But i guess i couldn't ask for a better for a price tag of... Read More »
Mahindra Bolero Alternatives
6.23 – 7.94 Lac
5.22 – 8.25 Lac
6.67 – 8.20 Lac
7.81 – 11.55 Lac
8.29 – 14.33 Lac
Other Mahindra Cars
5.72 – 6.43 Lac
6.67 – 8.20 Lac
8.29 – 14.33 Lac
5.22 – 8.25 Lac
5.43 – 7.66 Lac
6.01 – 6.91 Lac
11.29 – 16.20 Lac
7.81 – 11.55 Lac
Mahindra Bolero OverviewMahindra Bolero, one of the oldest MUVs in Mahindra's portfolio, has been consistently leading utility segment sales from last 7 years. Launched way back in 2000, Bolero evolved and got better and better with changing times and tastes of consumers. The present Mahindra Bolero presents a perfect blend of advanced technical features, a well refined power mill, and intriguing interiors. Mahindra offers this MUV in three versions mainly – SLE, SLX, and the top most ZLX. These three categories have models complying with BSIII and BSIV emission norms because of which the number of variants totals up to 18. All these variants are powered by a tuned 2523cc m2DiCR diesel engine that delivers maximum power worth 64PS against a peak torque of 195Nm. The performance of this engine is aided by micro-hybrid technology that reduces fuel consumption when engine is on standby mode. Powered by this engine, the MUV delivers a mileage of 15.96kmpl over highways as certified by ARAI.
In respect to looks and style, Mahindra Bolero makes quite aggressive and bold statement. Right from its chassis, headlights, wheels, to side footsteps, windshield mirrors, and windows, all features have been designed keeping in view Indian roads and weather conditions. The vehicle carries a capacity to accommodate 7-8 people normally along with sufficient luggage. A high ground clearance of 180mm, turning radius of 5.8 meters, and a brilliant suspension & braking system allows this car to pass through smoothly trade
through all kind of rough surfaces and terrains. This specialty makes it highly suitable for sub-urban and rural areas which are full of rough and uneven roads.
Bolero's interiors have also been laden with a number of upgraded features that ensure better comfort and safety to its passengers. Apart from an efficient air conditioner, the MUV features power windows, dual tone upholstery, a digital display, voice messaging system, a stylish electric steering, centre arm rest with front & middle seats, adjustable head restraints, and a few others. The safety aspects have also been improved with incorporation of new features like keyless entry, central locking, door ajar warning, power windows & steering.
Mahindra Bolero ExteriorIn terms of looks, design, and style, Mahindra Bolero seems inferior to none. It's sturdy looks and robust design gives it an aggressive appeal which is enhanced by its hawk-eye headlamps.
The car mainly targets large families that need to travel along with lots of baggage especially in country sides, the flat design and appearance of the car points towards the same. The vertically segmented grille underlined by a body toned bumper with fog lights imparts a bold look to its front fascia.
The side profile, on the contrary, is marked by unique body graphics, foot-steps, large windows, and gates that allow easy ingress and egress from the car. The rear is marked by crystal finished tail lights and a spare wheel. A ground clearance of 180mm helps keeping its lower side safe from rubbles and harmful objects over rough roads.
The ribbed roof provides required rigidity to the top and improves helps improving its aerodynamics. The smooth finish provided by Mahindra blesses the car with an impressive on-road appearance that makes it suitable for 1-tier, 2-tier, as well as 3-tier cities and towns.
Mahindra Bolero InteriorNot only in terms of strength, is Bolero also counted for offering quality interiors now. The seats are dual colored seats have been designed ergonomically that offer ample comfort with short as well as long journeys. Special comfort features like center arm rest on middle seat and new ac vents surrounded by fake wooden consoles have been ushered across all the variants except the basic model.
Adjustable head restraints with all seats add to your comfort level while seat belts with front and middle seats helps keeping passengers safe from sudden jerks and shocks. The multi information display mounted over dashboard indicates fuel efficacy, remaining fuel, and gears all time. The extended wheel base of 2680mm has been well utilized to provide optimum leg room, elbow room, and shoulder room in all the three seat rows.
The windows as well as windshields are large and low that allow a clear lateral and front view. The accessory package offered with the MUV includes a Kenwood audio system with FM radio, an AUX-in port, and 4 speakers. Except the base model all other models are offered with Air-Conditioners, center arm rests, adjustable head restraints, and several others. Those looking for adding other accessories may go online and purchase them. A boot space of 430-litres seems enough to swallow all your bed and baggage for all kind of trips.
Mahindra Bolero Engine & TransmissionMahindra has loaded Bolero with a 2523cc common rail M2DiCR power mill that churns power worth 64PS against a leading torque of 194Nm. One of the best features of this power mill is its low maintenance costs that, to a larger extent, reduce overall ownership cost of the vehicle. The engine is fine tuned as compared to the last one and allows the car to start with AC even in second gear. The NVH level still needs to be looked into; even at low speeds you can feel noise and vibrations. The ride quality is good provided the speed is maintained within 100kmph. As you cross the 100kmph speed mark the vehicle starts getting a bit imbalanced. The best feature is the micro-hybrid technology that helps improving the fuel efficiency of the vehicle. The unique start-stop system brings the car's engine on a standby whenever the car is on standstill mode for a long time.
And whenever you need to start again, press the accelerator a bit and the engine races back to life in a moment. The main strength of Bolero's engine is in its ability to perform in all kind of rough, dusty, uneven roads 5-8 passengers and ample amount of load. Figures wise it may not sound that great but it carries ability give appreciable performance on basic Indian 2-tier and 3-tier cities roads which are completely different from 1-tier cities paths. This tough performance is supported by a 5-speed manual transmission that helps the in sprinting from 0 to 100kmph speed mark within 26 seconds.
Mahindra Bolero MileageMahindra presents quite a decent and well mannered vehicle in form of Bolero that gives an unmatched performance over rural paths. The 2523cc engine that churns power worth 64PS helps Bolero deliver mileage worth 16kmpl which is confirmed by ARAI. Though the performance may vary in various conditions, for e.g. on a hot summer day when you need Air Conditioner throughout the day the mileage figure may go down to 13kmpl. On traffic stricken city roads the same figure comes down to 12kmpl. The Micro Hybrid system plays a great role in improving its fuel efficiency to a larger extent.
Mahindra Bolero Braking and SafetyMahindra Bolero has been loaded with a combination of disc and drum brakes which aid its braking operation in front and rear portion respectively. This combination helps assuring a steady, comfortable, and safe journey to its accommodators. Bolero is a MUV mainly designed for 3-tier towns and rural areas, and hence Mahindra ensured to provide the car with braking as well as safety measures in association with that. The biggest safety feature of this MUV is its robust built that keeps the car in place under all conditions. Other than that Mahindra updated the top end versions of the car with a voice messaging system that warns the driver from time to time. All versions of the car have been presented by a pair of front fog lamps that show path during bad weather.
The upper end models have been blessed with power windows whose switch is located on central console. The new model has also been updated with latest features like keyless entry that prevents unauthorized access into the car, central locking , engine immobilizer that helps in saving the car from thefts, and a power steering that ensures smooth and safe maneuvering all time.
Mahindra Bolero Performance and HandlingMahindra designed Bolero with an aim to cater 2-tier and 3-tier markets. That is the reason why the MUV is blessed with a diesel engine and not a petrol one. The car performs pretty well over low speeds and offers good control and drivability till speed goes above 100kmph. The vehicle seems a bit unbalanced after that. The gear shifts are pretty smooth, even when the car is completely occupied one can easily shift to 4th and 5th gear even at lower speeds. With all these features, Bolero manages a crisp presence over the road and presents one of the best travelling options in rural and sub-urban areas. Bolero's performance is one of the best recorded performances in rural areas till date. Another feature that adds feather to its cap is its suspension system that keeps its accommodators in place in all kind of tough paths. The front end of the car gets supported by an anti roll bar and coil spring over front end while the rear gets supported by Elliptical leaf spring that handles the car in the most rugged paths.
What do we think about Mahindra Bolero?Be it performance or price, Mahindra Bolero is the best option you would love to consider in all aspects. Its affordability, performance, ruggedness are some of the main aspects through which it has set a series of industrial standards in its Indian MUV segment. The common perception about utility vehicles was of a vehicle that had a sturdy body design, high weight, and dealt with ample amount of power. Bolero not only changed that perception but also created high competition standards in this segment. Be it power, performance, toughness, comfort, or convenience, Bolero offers a complete package along with an affordable price sticker. The car's presence over roads is a hard-to-miss show given its bold features, aggressive styling, and large size.
The interiors are roomy and except the base model, the mid as well as top version offer latest comforts. The fake wooden inserts may seem a bit inappropriate to some, but on a whole the car interiors look standard and contemporary. The inclusion of fresh features like keyless entry, rear wash & wiper, power steering, Voice Messaging System, engine immobilizer, and other is welcoming. The safety measures are better and upgraded but Mahindra may have to revise the list as absence of ABS (Anti-lock Braking System), EBD (Electronic BrakeForce Distribution), and airbags in top end models can become a big backdrop in coming times.
The best feature of Bolero is its low maintenance cost whose prime credit goes to its 2.5-litre m2DiCR diesel engine. Application of micro hybrid technology increases its fuel efficiency and reduces overall ownership cost of this MUV. Bolero's fuel tank has a capacity of 60 liters which means in one single tank fill the car can easily cover a distance of 960kms. The suspension system is pretty strong which keeps the car stable in the roughest and most uneven paths.
Mahindra's extended network of dealerships and service centers is another feature that makes it a preferred choice in rural areas. Be it performance, price, load carrying capacity, or after sales service, Bolero is a all round package that meets all consumer needs and expectations flawlessly.
Mahindra Bolero CompetitorsThe vast expanded network of Mahindra and Bolero's rugged performance in all kind of areas made this MUV number one in its segment. From last 6 consecutive years, Bolero has been leading sales figures. The MUV mainly competes with Maruti Suzuki Ertiga, Tata Sumo, Chevrolet Enjoy, Nissan Evalia and a few others. All these mentioned cars take an edge over Bolero in terms of comfort features, a few in terms of power and performance, and a few for their design and style. But when it comes to extended reach, market penetration, and brand value there's no match to Bolero. Mahindra's long standing in commercial segment makes it one of the most trusted and affordable brands in rural and sub-urban areas which is one of the main reasons why Bolero stands apart and above all others. Last but the most important feature, the ability of Bolero to perform and bear all kind of loads on all kind of rough terrains is unmatched which makes it unchallenged leader of this segment.


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After School Marine Biologist
Serious Science - No Homework!
Are You a Future Marine Biologist? Get a jump start at the Marine Education Center's new After School Marine Biologist program. Spend one afternoon a week immersed in a learning environment with the scientists, researchers, and educators of GCRL's Marine Education Center. Sign up for either Monday or Wednesday in this once-a-week program. Note that start and end times are different for the three days.
Two sessions:
- Open to students in grades four through six.
- The program is limited to 18 participants.
Download or view the flyer:
Monday or Wednesday session
Mondays, 2:30 - 4:30 p.m. Wednesdays, 2:30 - 4:30 p.m.
2015 Spring Semester Topics
January - Outrageous Ornithology
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April - Crustacean Nation
May - Mucho Mollusks
This is NOT for couch potatoes. There will be hiking, kayaking, fishing, dissections, and chemistry. Children gain new skills and experiences that will last a lifetime. Once a week, participants embark on a field study excursion by hiking or boating or participate in a lab activity.
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Tuition includes fees for boats, kayaks, bus transportation, program materials, field equipment, laboratory materials, and specimens. An afternoon snack is provided; after all, they are going to need some energy!
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Call a marine education specialist at 228.818.8890 or email us at firstname.lastname@example.com.


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This GGI CompactFlash Type I & II Card Reader accepts any brand of CompactFlash or Microdrive memory card inserted into its single slot, and transfers the stored data to your computer through its fast USB 2.0 interface. Simply connect the reader to a USB port on a desktop or laptop computer, and insert your memory card - no software drivers are necessary to use this reader on most Windows and Macintosh computers.
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After seeing panaceabeachbum's posting of his mini's, thought would share mine too. All are 1/2 scale semi autos of the M2, 1917 water cooled, and the 1919 air cooled.
These are not kits, but scratch built models from CCS Prints (http://www.ccsprints.com/). They use a modified Ruger 10/22 receiver and barrel to maintain the semi-auto function. This was a low cost alternative, for me anyway, to have .22 semi auto model of these guns. I also built my own ammo cans and transit cases. These models keep the Ruger rotary mag feed.
Here is the M2
The M2 in the transit case
The 1919
The 1917 at a show
The 1917 and 1919 in a common transit case


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Dr. Wilson Speaks to Rotary
Dr. Valerie Wilson of Ohio Christian University was the program speaker at the Circleville Noon Rotary meeting held March 1; she discussed reading recovery for students and is pictured with club president, Charles Hedges. Student guests in attendance were Zachary Davis and Eric Tinney from Pickaway-Ross CTC.
Published in the Circleville Herald on March 07, 2007.


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Posts Tagged «nintendo 64»
The worst storage mediums of all time May 15, 2014 at 12:03 pm
Papyrus and movable type were huge steps forward in their times, but the 20th century saw massive jumps in data storage. Paper and ink gave way to magnetic tape and various types of disk, and suddenly humanity could store so much more than just the written word. Unfortunately, we've also hit some major speed bumps along the way.
How storage media decides the fate of console games March 24, 2014 at 11:30 am
As long as video games have been in existence, they've been seriously constrained by technical limitations. There's only so much RAM, CPU power, and storage space to go around, but that's not always a bad thing. In fact, the quirks of the hardware can actually help mold the way games are designed, and there's no better example of that than storage media itself. From diskettes to Blu-rays, the oddities and limitations of the given medium dictate what kind of games can be made.


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the main winners of the day were
Judge(s): MR BOB GREGORY
As of the 1st APRIL 2013 the Eurasier is now off the Import register and will have Breed classes at open and Championship shows in the future, please check our SHOW PAGE for full up to date results
Great news.
We received a Letter from the Kennel Club on the 22nd of April 06
Outlining the New Interim Breed Standard for the Eurasier.
It was quickly and thoroughly passed to all Committee Members for their approval. I am Happy to report that it was accepted by all. A letter has now been sent to the Kennel Club to that affect, to be included in the next Issue of the Kennel Gazette which is due out in May. Then and only then will be be able to enter our dogs into UK shows for exhibition, For shows that Entries Close on or after the 1st of June 2006 once and only if it has been published in the Kennel Gazette.
Bad News i'm afraid,
I have just come of the phone after talking to the Kennel Club. Only to be told that the Breed standard still has not yet gone through. Very disapointing news for us in the UK,
I know a lot of us were hoping to show our dogs, at the Manchester Champ Show, but looks like we will have a much longer wait.
The next KC meeting is on January 31st, so lets all keep our fingers crossed for that date, but dont try holding your breath. This seems to be dragging out a long time, with nothing happening. But things are moving, be it all very slowly, it has got to be worded correctly into English so as not to differ away from the FCI Standard.
As soon as we get any more news I will put it on here.
The Eurasier Club of GB (proposed) was delighted to be
Invited to Attend
Discover Dogs at Earls Court London on the 12th and 13th November 05
We were the ONLY ones to have been Invited to attend Discover dogs as Members of the Discover Dogs Display.
Any portrayal on another web site of any other Eurasier persons that may have been present there on the two days.
Was unbeknown to the Kennel Club, and therefore is Unsanctioned by them.
Saturday 12th.. This was attended by Sue and Bill Turner and Alison Carter,
with Diesel, Kore and a very bouncy pup Buck.
From the moment the doors were open at 10 am, we were inundated with the public. The Eurasier Stand was at bursting point at one stage, and all three of us seemed to be talking to 3 people at once, lol.
The dogs were very well behaved with Kore and Diesel knowing what it was all about as they were at Crufts Discover dogs earlier this year. Buck is only just 6 months old, so was all very excited by it all, and loved all the attention. and was happy with all the flashes of cameras going off with the hundreds of photos that were taken of them. what a little star he was there. We had one scary moment with our young pup when a child with a very large fluffy toy on his shoulders , (that had been won from one of the many stands at discover dogs) leaned over the pen to pet up the dogs and this fluffy toy toppled of his shoulders and landed on top of Buck. Well Buck was very startled and proceeded to bark at it. and at every other fluffy toy that passed him for a while, his bark was always with a wag of his tail and jumping up at the side of the pen, like he was saying Look mum there's another one, and another one !! Take the hint mum !! I want one ... so i took the hint and got him his own, Buck and fluffy toy were then quite happy together.
It was a long day with people still walking around right to the end, and by that time the dogs and us were very tired and glad to be heading home. a good and pleasant time was had by all of us.
Sunday 13th ... this was Richard and Tracy's day with their two Eurasiers Lexi and Pepper. Again Lexi was fine as she also was at Crufts this year. But Pepper is Bucks Sister, so was also new to it all. Although Richard and Tracy arrived a little late, due to traffic, they had a crowd waiting for them at the stand when they arrived. They have informed me that photos were being taken of the dogs before they had , had a chance to put them in the Discover dogs Pens. Both dogs behaved themselves as they should. Greeting the public with a wag of the tail. Again by the end of the day all were ready to come home and have a much deserved rest.
It seems to us that the Eurasier is a dog that could take off as a breed in this country very fast,
But we would hope that the right type of people for this loving but reserved breed, will be the ones that will share their lives with them. Please if you are Interested in an Eurasier to share your life with, Do your homework on the breed first. Find out their needs, Ask about Hips , eyes. Patella's, Temperaments. Go and Visit your Breeders Home, See the dogs in a family environment, before there are any puppy for you to go and see, "Every one loves a puppy," and that could be your first mistake, Look at the adults, make sure that you can cope and have room for a dog of that size. ask about grooming , Moulting. ect, In fact make a list of all the things no matter how silly they may seem to some breeder, they are what YOU need to know.
Take it with you and expect ANSWERS...
Crufts 10-13th 2005
Discover dogs
The Eurasier club of
We all had a fabulous time and the dogs never put a paw wrong on any of the days.
Day 1, Astras, Diesel, and their granddaughter Kore attended, with me (sue) Bill, Toni, Alison, Derek.
We were all kept busy and on our toes, from the moment we arrived with only a couple of time during the day, where things went a bit slower, enabling us all to have a cuppa (whew ) and did we need that cuppa.
Day 2. This was attended by Lexi, with owners Richard and Tracey,
Another very busy day, this was Lexis's first time, in this kind of exhibition , well any kind really as she is only 8 months old. And she got asked to take part in the Dogs Day out Training class and guess the breed.
Day 3 This was the day for Akira and Dylan with owners Charlotte and Sharon. Unfortunately Dylan and owner Sharon could not make it so
Day 4. Diesel, Kore and Lexi, were the dogs on the stand this day with all owners, and even extra Eurasier people came to give us a break, and do their part on the stand.
Today was Kore's turn to do guess the breed, and a training lesson with Dog's Day Out.
She did this with Chris, who has never handled Kore before, what made it very special is Chris is in a wheelchair, Kore has never walked beside a wheelchair before, but behaved very, well much to our relief.
There is so much interest for the Eurasier, and many, many, People asking when we are able to start to show them. Well of course this is in the hands of the Kennel Club and the acceptance of the breed standard. This was sent into the Kennel Club over a year ago. We are hoping for the breed Standard to be read at the KC next meeting to be held on 19th April. After which time we hope to be given a date for us to start campaigning our Eurasiers at shows in the Import Classes.
Summary, a great time was had by all of us that attended, and the dogs behaved so well. We are all very proud of our Eurasiers, and to have been a part of Discover Dogs at Crufts 2005.
Sue Turner


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This weatherproof vinyl bag from Däv cinches at the top to keep the rain out. $55; Davrain.com
How to Look Thinner


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Home/Val Stefani Bridal/Bridal/D8007
Style D8007
Finely handcrafted silk taffeta flowers along the skirt and hem create a vision of romantic beauty. Mermaid gown with Swarovski crystals adorn the center of each flower. Couture beaded bow accentuates the deep sweetheart neckline. Finished with covered buttons down the zipper.
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Hotels in 44090 - Wellington OH
Only hotels in 44090 zip code are listed below. Search for cheap and discount hotel rates in Wellington, OH for your upcoming leisure or conference / group travel. We list the best 44090 hotels and motels so you can review the Wellington hotel list below to find the perfect lodging. Hotels in Lorain county and area code 440 are also listed.
44090 Hotels/Motels & Accommodations
Next: Show All Available 44090 Hotels with Pricing >


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Articles About pesticide
Village using pesticide alternatives
Warning signs pop up on local lawns each spring as local residents contract with companies to treat their lawns with chemical pesticides and fertilizers for the season.
Pool re-opens, controversy goes on
Village Council will decide at its July 1 meeting when to remove the fence around the grassy area where herbicide was over-applied.
Profile of the herbicide 'Escalade 2'
According to Dr. Jason Russell, a medical toxicology fellow at the Ohio University College of Medicine who works at the Nationwide Children's Hospital in Columbus, villagers have "not much to worry about."
Pool closed 2 days after herbicide application— Spraying sparks controversy
Several villagers spoke passionately and heatedly about their frustrations and fears around the Wednesday, June 12, overuse of herbicides on the grass around the Gaunt Park pool at Village Council's June 17 meeting.
A public reading of Rachel Carson's Silent Spring
A public reading of Rachel Carson's Silent Spring will be held Saturday, June 22, 8 a.m.–noon at the Farmers Market.
AGENDA for Council's special meeting on herbicide use around pool
Village Council will hold a special meeting on herbicide use around pool on Thursday, June 20, at 7 p.m. at Council chambers in the Bryan Center.
Village staff to alert swimmers about overuse of herbicide
The Village will contact those who swam in the Gaunt Park pool from last Wednesday to its closing late Friday afternoon to alert them that herbicides had been applied inappropriately Wednesday morning to the grass around the pool.
Emergency Council meeting on pool closure
The Yellow Springs Village Council will hold an emergency meeting on Sunday morning, June 16 at 9 a.m. in Council chambers to discuss the pool closing yesterday due to herbicide application.
Pool temporarily closed
On June 12, 2013, the Village staff applied an herbicide to the clover in the grassy area around the pool, forcing closure.
Borer likely dooms ash trees
Many majestic canopy trees around the village are ash trees. And if they're not already infested with the Emerald Ash Borer beetle, they will be soon. Within a few years, they'll be dead.


text:
MMA News
Rashad Evans Blog | Jon Jones Is Not A God
By Rashad Evans:
I went to Puerto Rico last week to promote my April 21 title fight against Jon Jones on pay-per-view.
The reception I got was the craziest I've ever had in my UFC career. It was the coolest thing I've done in this sport since I won "The Ultimate Fighter 2" in 2005. The fans were so insane; there were hundreds down there to see me, and then boxing legend Felix "Tito" Trinidad – who is in Puerto Rico – showed up and I got to meet him. I was a huge Tito fan when he was doing his thing in the 1990s and early 2000s. He was a great fighter who had skills, speed and a lot of power. It was really great to meet him and, even though I got in my workouts, my mind was off of UFC 145 for a few hours and it was one of the most insane experiences of my life.
I came back home feeling very energized and ready for the last couple of hard weeks of camp.
Funny, for this fight there's been a lot of questions about smack talk and there's going to be more come fight week – believe me – but meeting Trinidad and tennis star Victoria Azarenka a few weeks ago have been two of the coolest things I've done in the UFC.
Soon though, it'll be time to get serious. The April 21 fight symbolizes so much for me. It feels like everything I've been going through, everything in my whole career and in my life, has all been leading up to this moment and this fight.
Yeah, I want to beat Jon and prove a point that he's not this god we all need to pray to at night. He said on live TV that America could learn from him. I Googled it: There are 311,591,917 people living in America right now and Jon Jones thinks that 311,591,916 of them need to learn from him. He's a drop in a bucket like the rest of us. The guy praises himself going to sleep.
But the thing is, opponents have been buying into that, too.
Watching at ringside last September at UFC 135, I couldn't believe the way Quinton "Rampage" Jackson fought Jon. He gave him too much respect and way too much distance. You have to be "in" or "out" with Jon – either out of range looking to come in with strikes and takedowns, or you got to be in his face throwing and pushing his ass against the fence. He's got too much reach on you to be in the mid-range – that's his sweet spot – and you can't get caught out there with him.
I know Jones has tweeted and been doing interviews about me. That's what happens in big fights and especially this one. But I'm at the point where I'm not really bothered by anything he says. What he says makes no sense anyway. He thinks he's something so special people need to bow to him when they seem him on the street.
Does it motivate me? At this point, not really. There's really not much more he can say to me to motivate me. I'm already motivated for this fight; I'm motivated beyond reason. Yeah, I want to be the first guy to really beat Jon, yeah, I want my title belt back and I want to show my former trainer what's what.
But this fight is not about proving a lot of people wrong about Jon Jones; it's about proving me right… Continue reading over at YahooSports!
14 Responses to "Rashad Evans Blog | Jon Jones Is Not A God"
Evans will get a beat down like he has never seen. Finally, maybe, just maybe someone will shut this clown up once and for all. Rashad is NOT in the same league as Jones. It will not even be close. He loses in every department, speed, reach…good luck taking down Jones. He will play with you for a couple of rounds then finish you. You will be busted up real good. I can't wait. Shut this big mouth up Jones.
rashad aint even number 1 contender…he is hype train…machida would kill rashad again…i have always hated rashad he is truly cocky
I like the pic in the back.
And here i was thinking I was the only one to see that lol. Good eye sir
I agree with Rashad, Jon "Bones" Jones is no God, there is only one God and he is my lord and savior. For Jones to even say he is a God is horrible. But I am excited to be a Jet, and I'm excited for this fight
I'm just so excited.
TT is just hilarious when he speaks now
where is it that he mentioned he was God?
where is this interview where jones says "america could learn from me"
Jones asked for it to be removed.
Giggity, giggigt goo. Alright!
They should just make out already these guys have a crap load of sexual tension for each other!
A couple guys I train with trained at Jackson's while rashad was still there and they said for the most part rashad had jones number. And most of what rashad is saying is the truth
I cannot stand jon jones voice his smile his smug arrogant attitude his fake humble persona the way he sub conciously talks down to everyone he's a prize fraud character wise..but skilled although most of that is because of his insane height and reach advantage let's see him fight someone his own height like Anderson does..then I'll truly rate him.How can u hate rashad his cockyness 99% of the time is when he's joking he one of the most intelligent funny mms guys out there he's lost 1 fight in 20 odd u can't count him out he's an elite fighter giving away height and reach to nearly everyone..go figure.
I can see fear in Jones eyes. This kid is fraudulent and gonna crumple under pressure when Rashad takes it to him.
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|News Title
|Hurricane Sandy increases cloud disaster recovery awareness
|Dec 17 2012 - 2:57pm
|Public Cloud
After witnessing the devastating effect Hurricane Sandy had on the private sector, decision-makers around the United States realized the importance of establishing a robust disaster recovery program. This was highlighted in a recent study by Acronis, which...
|Report: IaaS, PaaS make up 12 percent of infrastructure market
|Dec 13 2012 - 3:54pm
Although Software as a Service often takes the majority of the credit for the emerging cloud market, Platform and Infrastructure as a Service are also gaining momentum and encouraging...
|Big data importance drives cloud demands
|Dec 12 2012 - 3:26pm
|Cloud Computing
Companies of all sizes are accumulating, storing and trying to make sense of growing amounts of information to improve operations and meet ongoing customer demands. Mining and analyzing...
|Hosted private, industry-specific clouds to grow in 2013
|Dec 11 2012 - 3:47pm
|Private Cloud
While the cloud had a phenomenal year in 2012, 2013 is also expected to be a big year for the technology, especially as more decision-makers adopt the hosted service and become more familiar with its benefits. More specifically, a number of trends related...
|Report: Cloud, mobile and big data drive IT industry
|Dec 3 2012 - 4:07pm
|Cloud Computing
The ongoing migration of work-related operations to the 3rd Platform has inundated the IT landscape, convincing decision-makers around the world to leverage innovative technologies to remain competitive. While there are many technologies spurring this...
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The Bauza Collection contains approximately 260 manuscript maps and 300 written geographical and statistical texts relating to Spanish America, the Caribbean and the Philippines, dating from about 1700 to around 1830. They were assembled between 1804 and 1834 by Felipe Bauza (1764 – 1834), head of the Spanish Hydrographic Office from 1815 to 1823. The collection was purchased by the British Museum in the 1840s, and is viewable in the Manuscripts Reading Room of the British Library.
The collection consists of:
- Manuscript maps and papers from official Spanish archives, including that of the Secretary of State, which were salvaged or purchased by Bauza during the time of the Napoleonic occupation of Spain from 1795 to 1814.
- A number of charts and papers from the Spanish Hydrographic Office.
- Charts and memoirs compiled by Bauza himself whilst serving as hydrographer to Alessandro Malaspina's expedition to the Pacific (1789 – 1794) and during his time in London from 1823 until his death 2 years later.
- Maps and papers communicated to Bauza by various contacts in South America.
Several of the maps are annotated by Bauza to show geographical positions: he intended to use the collection as source material for remapping Spanish America.
The Bauza Collection is held in the Department of Manuscripts at the shelfmarks Add MS. 17556 to Add MS. 17676 inclusive.
Diseno orizontal de las ruinas de Pachacamac que se hallan en lo mas S. de un arenal de 2 1/2 leguas de largo aquien nombran la Tablada de Lurin, al N. del rio de este nombre, y cerca de la costa;" Add 17671 P
- A series of maps and memoirs relating to the demarcation of the frontiers between Brazil and Spanish America, containing much information about the indigenous population.
- Maps of the northern border of Spanish America. This includes a volume of plans of settlements in what are now New Mexico and California by the Spanish corps of engineers from 1766 to 1777 (Add. MS 17662), with the earliest known plan of Santa Fe, New Mexico.
- The collection does not include any maps of Brazil or of the Viceroyalty of New Granada (roughly corresponding to Ecuador, Venezuela and the neighbouring countries). These were sold to the government of Venezuela before the remainder of the collection was acquired by the British Museum, and have since been lost.
Finding Aids / Further Reading
The British Library Manuscripts Catalogue should be consulted for a concise listing of the maps and papers of the Bauza Collection.
Bauza Collection Catalogues. Vol. I. List of the collection as offered to the British Museum by Francisco de Michelena y Rojas in 1845, with an annotated list of the items acquired by the Department of Manuscripts in December 1848, 1845.
Add MS. 62904
Barber, Peter.'"Riches for the Geography of America and Spain": Felipe Bauzà and his topographical collections, 1789-1848', in British Library Journal 12/1 (Spring 1996), pp.28-57.


text:
CTBT in the News
|Friday 31 July 2015
Conférence de presse du Secrétaire exécutif de l'Organisation du traité de l'interdiction complète des essais nucléaires : «Le Niger s'est acquitté de tous ses droits et devoirs vis-à-vis des questions de non-prolifération et de désarmement» (Le Sahel)
安倍向联大提交废核新决议 或邀政要访问核爆地 (Huanqiu)
For 50 years Republicans have fought against treaties that brought peace (Investment Watch)
For North Korea, Iran-Style Nuclear Deal Not an Option (The New York Times)
Regional powers to meet over N. Korea's nuclear program (Yonhap)
N. Korea blames US for stalled nuclear dialogue (Yahoo News)
Iran says will ban US experts from UN nuclear inspections (Yahoo News)
U.S. political fight over Iran nuclear deal goes Hollywood (Reuters)
Joni Ernst: Iran deal a 'pathway to nuclear armament' (CNN)
4 Democrats get behind Obama's Iran nuclear deal (Yahoo News)
Amos Yadlin: Israel Concerned Nuclear Deal Marks US Pivot to Iran (The Algemeiner)
Israeli diplomat: majority of American Jews support Iran nuclear deal (The Arab American News)
Huckabee: Don't repeat history with Iran nuclear deal (KCRG)
Lieberman: Obama Faces Uphill Battle In Selling Congress On Iran Deal (CBS New York)
PunditFact: Bill O'Reilly challenges Mike Huckabee on Iran nuclear deal alternative (Tampa Bay Times)
Obama Has A Plan To Protect The Iran Deal In August, His Least Favorite Month (The Huffington Post)
Overnight Defense: Pelosi says House Dems will keep Iran deal alive (The Hill)
Lawmakers pressing IAEA for details of Iran side deal (Washington Examiner)
Russia reassures Israel over Iran nuclear deal (Yahoo News)
Iran Nuclear Deal Will Have Positive Effect On Middle Eastern Security And Stability, Putin Assures Netanyahu (International Business Times)
Putin to Netanyahu: P5+1 Deal Guarantees Peace in Iran Nuclear Program (Sputnik)
White House warns Congress once again not to kill Iran nuclear deal (Press TV)
Kerry Five-Nation Tour to Cover Security, Iran Nuclear Deal (VOA)
Netanyahu: The more one looks at the Iran accord, the worse it looks (The Jerusalem Post)
Nuclear deal not intended to 'reform' Iran regime: Kerry (The Times of India)
Deal keeps Iran from atomic bomb: Dempsey (Dispatch Times)
Former NATO Supreme Allied Commander: Iran Nuke Verification Program "Resembles Swiss Cheese" (The Tower)
Here's How to Rid Korea of Nuclear Weapons , by Lyle J. Goldstein (The National Interest)
The Iran Deal's North Korean Shadow, by Christopher R. Hill (Project Syndicate)
Iran Deal: It's Time for Some Serious Talk, by Jim Wallis (The Huffington Post)
Iran nuclear agreement: Is a 'better deal' possible – and at what cost?, by Howard LaFranchi (Yahoo News)
Why Republicans Oppose the Iran Agreement: Follow the Money, by Jeff Faux (The Huffington Post)
This Is What Will Happen if Congress Blows Up the Iran Nuclear Deal, by Suzanne Nossel (Foreign Policy)
Experts Weigh In on the Iran Deal, by Elise Cooper (American Thinker)
Iran deal or no deal, what's Israel's next move?, by Uriel Heilman (Jewish Light)
Open letter: don't ratify the Iran deal, by Paul Kujawsky (Jewish Journal)
Op-Ed: 'Peace for our time', by R. James Woolsey and Peter V. Pry (Arutz Sheva)
Media Outlets Cite Conservative Group's Flawed Poll On Iran Deal Without Disclosing Misleading Question, by Rachel Calvert (Media Matters)
Iran Nuclear Deal: Don't Think Nixon in China, Think Yalta, by Russell A. Berman (Newsweek)
Iran: Obama Admin Lying About Nuclear Deal for 'Domestic Consumption', by Adam Kredo (The Washington Free Beacon)
Two brave Democrats publicly oppose the Iran nuclear deal, by Ethel C. Fenig (American Thinker)
Safeguards in treaty leave Netanyahu without a first-strike option, by John B. Quigley (Bradenton Herald)
Charen: Will Jewish Dems sink Iran deal?, by Mona Charen (Chicago Sun Times)
Obama gets personal with Dems on Iran, by Lauren French (Politico)
Dear Congress: You can stop the 'new Holocaust, by Aliza Davidovit (WND Commentary)
Strategic Command Focused on Hypersonic Missile Threat, by Bill Gertz (The Washington Free Beacon)
Iran Deal Or Not, World Nuclear Threat Is Worse Than Ever, by Nathalie Guibert (Worldcrunch)
Does Iran Already Have Nuclear Weapons?, by Stephen Bryen and Shoshana Bryen (American Thinkers)
Iran's Secret 200-Year Strategy, by Niel Green (The National Interest)
The best reason for rejecting the Iran agreement is to rebuke the president's long record of aggressive disdain for Congress, by George F. Will (National Post)
W. E. B. Du Bois to Malcolm X: The Untold History of the Movement to Ban the Bomb, by Vincent Intondi (The Huffington Post)
Hitler's Nazis developed an atom bomb carried by a flying saucer, documentary claims, by Stephen White (Mirror)
Hiroshima atomic bomb survivor: 'Boom. Boom. Gone. All gone.'(Alabama)
Smithsonian special on bombing of Hiroshima has R.I. link (Providence Journal)
Nuclear Bombing of Hiroshima, Nagasaki Was Unjustified – US Experts (Sputnik)
When the cloud parted (The Economist)
Hiroshima: The Sickness of Nuclear Proliferation, by Joseph Cooper (The Huffington Post)
** This bulletin contains links to web sites not under the control of the CTBTO. The CTBTO provides these links as a convenience for the recipients of this bulletin and is not responsible for their contents. The inclusion of a link does not imply endorsement or approval of its contents by the CTBTO.


text:
Report Prepared By Lance Zierlein
TSV videos provided by Draft Breakdown
:28 Gets upfield then sheds tackle with effective arm over move
1:20 Explosive goal line penetration
1:38 Shows outstanding change of direction from inside to outside in contain
2:33 Instantly defeats first blocker and defends against cut block against second
3:18 Fluid drop into coverage but lacks closing speed and has to rely on deep angle to RB
3:37 Lowers pad level, takes on blocker with leverage and makes tackle on RB
4:14 Uses two hands to defeat the outside shoulder of the guard and then turns the corner
7:09 Quick hands get into tackle and gets seperation to the outside
TSV videos provided by Draft Breakdown
:24 Maintains QB responsibility on zone read but recovers to make tackle on RB
:45 Attacks outside shoulder, sheds and finishes with a tackle
1:04 Contains QB then shows good closing speed to finish with a sack
2:23 RB tries to cut him and shows good footwork to stay up
3:01 Looks fatigued
3:07 Lacks same get-off as early in game and falls in coverage
3:20 Gets good pop on guard, but shows average speed to RB
3:48 Shows off proper technique and footwork on spin move
4:25 Doesn't hustle on backside and RB goes for TD
6:24 Good inside move followed by awareness to bat pass
Murphy posted three highly productive seasons earning a variety of first team All-American honors. Murphy is the best defensive player in the Pac-12 thanks to his versatility and consistent production. Teams will love the fact that Murphy has shown improvement each year he's played and his sack numbers highlight that as they've grown from 6.5 to 10 to 15 over the last three seasons.
Murphy was the top pass rusher in the country thanks to his burst off the snap, his efficient pass rush skills and his outstanding usage of hands. Murphy is able to set up counter moves off of his quick first step and he takes direct paths to the quarterback. One of the things I like most about him is how infrequently he stays engaged with the lineman in front of him.
With good bend and technique, Murphy showed ability to set the edge effectively against the run. While Murphy can drop into coverage as a 3-4 OLB, that isn't his strength and he could be exploited in the NFL if asked to do so. Production and energy shows noticable drop-off when he starts to fatigue.
I see more burst from Murphy when his hand is in the ground and I see him as a very capable run defender who has the frame to add another 10 pounds of mass. While Murphy can play OLB or DE, I think his best fit will be as a 4-3 DE who can attack off the edge; however, his ability to play in an odd or even front will add draft value.


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