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Caregiverlist provides senior care information by senior care industry professionals. Caregiverlist's blog posts include Monday's Caregiver Stress Relief Photo, Tuesday's Senior Issues blog by Renata Jasinski Laszuk and Paige Krzysko with her popular Tech Friday blog.
Get notified when a new post is published.
Yesterday's Caregiverlist Blog post mentions the free memory loss testing at 2,000 locations nationwide provided by the Alzheimer's Foundation of America (a few drug companies are sponsoring this so it is free for seniors).
Why is early detection important? Because it can enable the senior and their family to understand the progression of various forms of memory loss to prepare for the progression and to implement systems for safety and proper care.
What are the types of dementia? Alzheimer's Disease is talked about the most but is not the only type. This is why it is important to be diagnosed for the type of memory loss in order to receive the best treatment.
Other types of dementia and other diseases and disorders which will also cause dementia are: Huntington's Disease, Pick's Disease, Frontal lobe dementia, Frontotemporal dementia, Lewy bodies, Normal pressure hydrocephalus, Vascular dementia, Parkinson's Disease, Subdural hematomas, brain tumors.
Also, some vitamin deficiencies and hypothyroidism can also cause some memory loss for seniors.
This is why it is vital to have proper diagnosis from a doctor trained in detecting the various forms of memory loss. A senior can be restored to health with some forms of memory loss when properly diagnosed or with medications and treatments can be able to slow the decline of memory loss.
As an owner of a senior home care agency, I saw many elderly clients who were visiting their same family doctor they had gone to for years and because this doctor did not include memory evaluation during the visits, it went undetected. Find out if your parent or grandparent or senior client you are providing care for is visiting a doctor who specializes in geriatric care - it does make a big difference.
Rush University's Geriatric Care Practice in Chicago is a wonderful example of an integrated approach to care for seniors. A social worker meets with each client along with the medical doctor and their team includes professionals in psychology and other areas. They also have an Alzheimer's Disease research department which offers support groups and participation in studies and their Anne Byron Waud resource center is free to seniors and offers everything you would want for a senior resource center. They make sure seniors are prepared for their emotional and physical needs as they age. Check it out and find something similar in your area - if Medicare is paying the bill for the doctor, you might as well go to one specializing in senior care needs.
Senior Caregiving
Just wanted to mention the Alzheimer's Association offers a hotline number to call for assistance in your area and they also offer free educational programs: 24-hour firstname.lastname@example.com
And not all memory loss means dementia. Here's a great article I found on age-related memory loss: www.helpguide.org/life/prevent_memory_loss.htm
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Eating Well As You Get Older
Frequently Asked Questions
1. How can eating well help me stay healthy?
Video length: 5 min 2 sec
Click to watch this video
Good nutrition is one of the best ways to stay healthy. Eating a well-planned, balanced mix of healthy foods every day may help prevent heart disease, stroke, type 2 diabetes, bone loss, some kinds of cancer, and anemia. If you already have one or more of these chronic diseases, eating well may help you better manage them.
Making good food choices may also help you reduce high blood pressure, lower high cholesterol, and manage diabetes. If you have a specific medical condition, be sure to check with your doctor or registered dietitian about foods you should include or avoid.
Making good food choices also gives you the nutrients needed to keep your muscles, bones, organs, and other parts of your body healthy. These nutrients include vitamins, minerals, protein, carbohydrates, some fats, and water.
Eating well helps keep up your energy level, too. By consuming enough calories -- a way to measure the energy you get from food -- you give your body the fuel it needs throughout the day.

subset: commoncrawl


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[SHQ3200] "Washable" - Good joke
So, recently I have bought the earphones "SHQ3200" from Philips, and I was pleased with the quality they provided.
However, today after my work out I decided to wash my earphones. I used a damp cloth to clean them up, and few hours later I plug them to my phone and what happened?
Left speaker is 60% quieter than the right one. This is total bullsh**t, they're supposed to be washable, partly waterproof to resist a freaking clean-up! I can't even get a refund on them because I lost my bill. I bought them like 1 months ago :/
Do you have any ideas on how can I fix them? I can't even get inside the speakers without breaking them up
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Dear Sefrys,
we do apologise for the delay in getting back to you. I have sent you a private message, kindly check your inbox.
Thank you very much.
Kind Regards,
Philips Moderator TeamForum Mod
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CHICAGO - James R. O'Dell, MD, a rheumatologist and professor at the University of Nebraska Medical Center in Omaha, Neb., was appointed 2012 president of the American College of Rheumatology at the ACR's annual business meeting held this week in Chicago.
Dr. O'Dell is the Bruce Professor of Internal Medicine, vice-chair of internal medicine, and chief of the Division of Rheumatology at the University of Nebraska Medical Center in Omaha. For the past 27 years, Dr. O'Dell has served as the director of the institution's Internal Medicine Residence Training Program, directing the training of more than 600 residents.
Dr. O'Dell graduated from the University of Nebraska in Lincoln, Neb., with a Bachelor of Science degree in electrical engineering. He earned his medical degree at the University of Nebraska Medical Center and then completed a residency and chief residency in internal medicine at the institution. In 1984, he completed a clinical and research fellowship in rheumatology at the University of Colorado Health Sciences Center in Denver.
In addition to his leadership role at UNMC, Dr. O'Dell is the founder and director of the Rheumatoid Arthritis Investigational Network (called RAIN) - a 22-year-old group of rheumatologists conducting exclusively investigator-initiated trials to find better treatments for rheumatoid arthritis. The group's achievements include pioneering the use of triple therapy to treat RA, describing genetic factors that predict response to therapy, and designing and participating in studies to compare the efficacy of conventional and biologic DMARDs. Dr. O'Dell is also principal investigator of a large, multinational RA research study through the Veterans Administration's Cooperative Studies Program.
Dr. O'Dell's many scholarly publications include articles on his study of the success of triple therapy and authorship of a review, "Therapeutic Strategies for Rheumatoid Arthritis," in the New England Journal of Medicine. He has published more than 100 articles in top rheumatology journals, and served as co-editor of Arthritis & Rheumatism, published by ACR, from 2005-10. He presents frequently at national and international medical meetings.
His honors and awards include being named the University of Nebraska University-Wide Outstanding Teacher, receiving the Nebraska ACP Laureate Award, and being named a distinguished scientist at UNMC. In 2008, Dr. O'Dell received the UNMC Department of Internal Medicine Career Research Award.
Dr. O'Dell's has served in many leadership positions with ACR and its Research and Education Foundation for the past 20 years. He was president of the REF from 2005-2007, secretary of ACR in 2009, and ACR president-elect in 2011. He served as chair of Patient Giving for the REF's Within Our Reach campaign, chair of the ACR Registry Task Force, and first chair of the ACR Registry and Health Information Technology Committee. Some of his earlier committee leadership roles include serving as chair of the Annual Scientific Meeting Abstract Selection Committee in 1998 and 1999, serving on the committee that developed the ACR Guidelines for the Management of Rheumatoid Arthritis in 1996, and serving on the Blue Ribbon Committee on Access to Care in 1999. Recently, Dr. O'Dell chaired the association's Rheumatoid Arthritis Clinical Trial Investigators Ad Hoc Task Force, whose findings were published in the August 2011 issue of Arthritis & Rheumatism.
A vocal supporter of the University of Nebraska Cornhuskers sports teams, Dr. O'Dell has been married to home health nurse Deb O'Dell for 38 years. Their children include Kim and Andy Vasey, Jennie and Dan Egermayer, and Scott and Melissa O'Dell. They have two grandchildren, Georgie Mae Egermayer and Aiden James Vasey. Dr. O'Dell's hobbies include travel and woodworking.
The American College of Rheumatology is an international professional medical society that represents more than 8,000 rheumatologists and rheumatology health professionals around the world. Its mission is to advance rheumatology. The ACR/ARHP Annual Scientific Meeting is the premier meeting in rheumatology. For more information about the meeting, visit www.rheumatology.org/education or join the conversation on Twitter by using the official hashtag: #ACR2011
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|Mrs. Beulah Mae Wray Murphy
|Tuesday, 26 March 2013 13:47
Mrs. Beulah Mae Wray Murphy, age 84, of the Bow Community in Cumberland County, Kentucky passed away Monday, March 25, 2013 at The Cumberland County Hospital.
She is survived by her children, Freda Thompson of Celina, Tennessee, John Murphy of Bowling Green, Kentucky, Audrey Mae Murphy of Burkesville, Kentucky, Charles Murphy of Bloomington, Indiana and Samantha Monday of Burkesville, Kentucky, her sisters, Jean Wright of Indianapolis, Indiana, and Linda Wheeler of Jeffersonville, Indiana, 8 grandchildren and 3 great-grandchildren also survive.
Funeral services for Mrs. Beulah Wray Murphy will be conducted on Thursday, March 28, 2013 at 2:00 p.m. in the Memory Chapel of Norris-New Funeral Home, with burial in the Perkins Cemetery.
The family will receive friends after 12:00 noon on Wednesday, March 27, 2013 until the funeral hour on Thursday.
Professional services provided by Norris-New Funeral Home of Burkesville, Ky.


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Reef Bay Hikes
Join National Park Service Rangers for the premier hiking experience
in Virgin Islands National Park!
- Reservations and purchase of transportation vouchers for the Reef Bay and L'Esperance hikes, led by Virgin Islands National Park Service Rangers, is done through the Friends of the Park Store located street-side in Mongoose Junction. Vouchers may also be purchased by phone at 340-779-8700.
- Vouchers for transportation will need to be purchased at the time of reservation for $30 per hiker.
- The maximum number of hikers on any given trip will be 31. We will maintain a waiting list once hikes are filled up and we will notify those on the list as vacancies occur.
- Vouchers for the Reef Bay Hike will be available on the day of the hike on a space available basis; but this is a very popular activity and advance reservations are highly recommended.
- Inquiries about reservations for the hike at the NPS Visitor Center will be directed by counter staff to the Friends of the Park Store across the street.
- The schedule for trips will be as follows:
- January - April: 4 trips/week (Mon, Tue, Thur, & Fri)
- May - August: 3 trips/week (Mon, Thur, & Fri)
- August - October: 2 trips/week (Mon & Thur)
- November - December: 3 trips/week (Mon, Thur, & Fri)
The frequency of trips may be modified by the NPS based on demand or other conditions.
- The taxi to the Reef Bay trail head will depart from the NPS Visitors Center promptly at 9:30am and the boat will return to Cruz Bay between 2:00pm - 3:00 pm.
- Vouchers must be picked up from the Friends of the Park Store in Mongoose Junction, and can be done in advance. If you must pick up your voucher on the day of the hike, please do so at 9:00 am, when the store opens.
- You must have your vouchers in hand to board the taxi at 9:30am from the NPS Visitors Center and to board the boat at Reef Bay.
Please read the following message from the VI NPS Rangers with important hike info:
Hello Hikers!
We are pleased that you are interested in participating in the Virgin Islands National Park Service Ranger-led hikes of the Reef Bay and L'Esperance Trails.
Please take a moment to look over this guide explaining hike details and what the Rangers would like you to know before you go!
Please note these are not "easy" hikes. While most visitors hike them without problem, the following information will let YOU decide if this activity fits your interest and abilities. These back country trails are steep and rocky and you need good balance and a sure foot. The trails can be slippery, even when dry. Total hiking distance will be approximately 3 miles. Please take a moment to evaluate in advance if this hike is appropriate for you as there are NO REFUNDS for any reason within 24 hours of the hike (due to contractual agreements with the transporters).
You will be with a group (likely of about 30 people). It is important for the Rangers, and your own safety, that the group stays together for the duration of the tour. Please, stay with the group and even help your fellow hikers if needed. If you prefer to move at a slower pace, feel free to talk to your Ranger, before the hike if possible, so that we may try to accommodate you.
While the trails are mostly downhill, there are short strenuous uphill sections that demand agility and strength, and possibly the use of your hands and feet for stability. The hike is done at a reasonably steady pace with occasional stops for the Ranger to interpret and explain the historical and natural features of the trail. The L'Esperance trail has more uphill sections than the Reef Bay trail. It also has less shade coverage so prepare for longer stretches of open sun.
There will be different types of bugs and insects on the hike. Most are harmless and will likely be identified by your Ranger; however, there will be both bees and wasps on the trail. If you have severe allergic reactions to bee stings (anaphylaxis), YOU NEED to bring Epinephrine medication with you AND to notify your Ranger of your allergies prior to departure.
Quick Check List
- Sturdy footwear
- Water (2 liters per person)
- Sunscreen
- Bug Repellant
- Allergy Medications
- Parking Permit? (if parking at the VC-you need one! Get it at the front desk)
SKIP Program at Reef Bay from Friends of VI National Park on Vimeo.
Cancellation policies are as follows:
- If the hike is cancelled by the NPS, voucher-holders will receive a full refund or may rebook the trip at no additional charge
- If a reservation is cancelled more than 24 hours before the start of the hike you may rebook the hike at no additional charge, or receive a full refund
- There are no refunds for "no-shows" or cancellations for any reason (unless cancelled by NPS) within 24 hours of the trip. (i.e., after 9:30 am, the day before your scheduled hike).
- Call the Friends of the Park Store at 340-779-8700 for last minute questions or to cancel your reservation.


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Turkish Airlines is the country's national airline operating scheduled services to 126 international and 34 domestic cities in Europe, Asia, Africa, North America and South America. Headquartered in the Turkish Airlines General Management Building at Ataturk Airport in Yeşilköy, Istanbul, Turkish Airlines is run by aeronautical engineer Temil Kotil.
Transporting an estimated 25 million passengers per year, Turkish Airlines operate a reliable service for business travellers and holidaymakers. The airline's main base is located at Atatürk International Airport with secondary hubs at Adnan Menderes Airport, Esenboğa International Airport and Sabiha Gökçen International Airport. From here Turkish Airlines fly to a total of 160 airports worldwide.
The airline has more than 12,000 employees and is a member of the Star Alliance allowing frequent flyers to benefit from a range of rewards through their loyalty programme.
Passengers must check in one hour prior to the scheduled departure time of domestic flights and two hours for international flights. All Turkish Airlines passengers are advised to arrive at the gate 20 minutes before departure.
Baggage restrictions vary between classes; Economy passengers can check in 20kg and bring one item of hand luggage weighing up to 8kg. Business Class passengers are permitted to check in up to 30kg and carry two items of hand luggage at 8kg each. First Class can check in up to 60kg of hold luggage.
Seat pitch on Turkish Airlines flights is 32 inches for Economy passengers and 54 inches for Business Class ticket holders. First Class travellers can enjoy a seat pitch of 90 inches with recliner options.
Frequent Flyer Programme
Miles & Smiles is an exclusive frequent flyer program available with Turkish Airlines. Earn points to spend on flights including airlines of the Star Alliance. Check Turkish Airways information for membership details.
Additional Information
Turkish Airlines has a long history of sports sponsorship including FC Barcelona and Maroussi BC. The airline is also the official partner of Manchester United and carries the football club's crest and other imagery on the craft's fuselage. Turkish Airlines will transport the team during the Champions League matches.


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Glossary of Education
- Moderate Mental Retardation
- Intellectual functioning that ranges three to four standard deviations below the mean (usually 40-54 IQ range), concurrent with adaptive deficiencies -- moderately or trainable retarded individuals can learn self-help, communication, social, or simple vocational skills but only limited academic skills.
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Archive for the 'jobs' tag
NY Times Magazine: Can Anyone Really Create Jobs?
My first NY Times Magazine column on what politicians say and what they can actually do about the jobs crisis.
Wired: Smart Jobs Atlas
Read the big atlas of smart jobs in the US on Wired Magazine's site. Make sure to read all the pages. Or watch me present the findings at the Wired Business Conference.


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Ryan Scott Ottney
PDT Staff Writer
NEW BOSTON — The Village of New Boston has been closing in on drug activities over the past several weeks, making five drug-related arrests since Oct. 12.
According to New Boston Police Capt. Steve Goins, village police officers on Friday responded to CVS in New Boston and found a stolen vehicle parked on the lot. The vehicle, a green Pontiac Grand Prix, was reported missing by the Lexington (Ky.) Metro Police on Oct. 25.
The person found to be in possession of the vehicle was Charlene Lowder, 35, of Portsmouth. She was charged with a fourth-degree felony for receiving stolen property. Upon a search, officers also found three needles and syringes and a charge of possessing drug instruments was added. Another person with Lowder, Melvin McGuire, 53, of Sciotoville, was also arrested for having a felony arrest warrant out of Common Pleas Court for charges of failure to appear.
Goins said later in the day on Friday, at 7:22 p.m., officers also responded to call reporting a possible drug deal at Kmart on Rhodes Avenue. Upon arrival, Officer Kevin Lewis was told by Kmart security that a male and female in the store were seen to be exchanging money and pills together.
Lewis approached the female as she was leaving the store and identified her as Heather Breech, 24, of Lucasville, and discovered she had an arrest warrant out of Municipal Court for probation violation. She was arrested. Upon searching Breech, the officer reportedly found a cellophane wrapper that contained yellow tablets identified as Diazepam — a Schedule III drug.
After securing the female, Lewis approached and detained the male suspect — identified as Jason Mosley, 29, of Lucasville. Mosley was on felony probation with Common Pleas Court for felony drug possession. Lewis also found on Mosley a green tablet that was found to be Oxycontin — a Schedule II drug. Also found on Mosley were two Suboxone strips — a Schedule III drug.
Breech and Mosley were arrested for possession of drugs and the case will be given to the Scioto County prosecutor for possible consideration of charges of trafficking in drugs. Beech also had her two children with her and she was also charged with child endangering.
Goins also reported a drug arrest that occurred in the village on Oct. 12, when village police arrested Virgil Spriggs, 40, and Ryan Price, 28, both of New Boston on felony drug trafficking indictments from the Scioto County Grand Jury.
During the last several months, New Boston Police have been conducting drug trafficking investigations from information received on complaints from tips within the village, and cases were prepared and given to the grand jury in September when both Spriggs and Price were indicted. Spriggs was arrested for trafficking in Suboxone and Ryan Price arrested for trafficking in Clonazepam pills (a Schedule IV drug).
Anyone with possible information on drugs or crime can call the New Boston Police Department Crime and Drug Hotline at 740-456-4144. Callers can remain anonymous.
Ryan Scott Ottney can be reached at 740-353-3101, ext. 235, or firstname.lastname@example.com.


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Compositions for increased antioxidant potency of natural vitamin E(d-alpha-tocopherol), comprising alpha-, beta-, delta-, and gamma-forms of tocopherols and tocotrienols are disclosed. All of these compositions provide 400 International Units (IU), based on one mg of d-alpha-tocopherol provides 1.49 IU. These compositions showed antioxidant activities superior to natural d-alpha-tocopherol. These compositions are designed to provide protection of the cell membrane lipid layer, and protection against heart disease, cancer, and eye disease.
1. A method of maintaining cardiovascular health comprising the step of providing to a subject, a composition comprising about 55 to about 85% by weight of d-alpha-tocopherol, about 10 to about 40% by weight of mixed tocopherols comprising alpha-tocopherol, beta-tocopherol, delta-tocopherol, and gamma-tocopherol; and about 1 to about 3% by weight of tocotrienols oil.
2. The method of
3. The method of
4. The method of
5. The method of
This application is a continuation of U.S. patent application Ser. No. 11/311,533, filed Dec. 19, 2005, entitled "Natural Vitamin E Compositions with Superior Antioxidant Potency" which is a Continuation of application Ser. No. 10/321,318, filed Dec. 17, 2002, entitled "Natural Vitamin E Compositions with Superior Antioxidant Potency", subject matter of which are incorporated herewith by reference.
This invention relates to a novel composition comprising natural d-alpha-tocopherol, mixed natural tocopherols (alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol), and tocotrienols (alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, delta-tocotrienol) having a synergistic antioxidant activity more potent than the antioxidant activity of natural d-alpha-tocopherol.
Vitamin E is a generic name for a family of four compounds (forms) of tocopherols and four compounds of tocotrienols. All eight compounds have a chromanol ring structure and a side chain. There are four tocopherol forms (alpha, beta, delta, and gamma) with a fully saturated side chain; and four tocotrienol forms (alpha, beta, delta, and gamma) having unsaturated side chains with double bonds at the 3′, 7′, and 11′ positions in the side chain. The four compounds of both tocopherols and tocotrienols differ from each other in the number and position of methyl groups in the aromatic chromanol ring. Alpha-isomers have all three methyl groups in the chromanol ring. Beta and gamma have tow methyl groups but at different positions in the aromatic chromanol ring. Delta has only one methyl group in the chromanol ring.
Recently, the term natural vitamin E has become synonymous with only alpha-tocopherol. The vitamin E compounds are light yellow oils at room temperature and are fairly stable to heat and acid and degrade with alkaline conditions, and when exposed to ultra violet light, and when exposed to the oxygen air.
Foods that are rich in vitamin E include dark green vegetables, eggs, fish, nuts, soy beans, vegetable oils, wheat germ, and whole-grain products. However, foods are commonly depleted of vitamin E due to processing, refining and storage. After absorption in the intestine, vitamin E is transported to the blood circulation by lipoproteins. As a fat-soluble vitamin, vitamin E is amenable for entry and storage in cell membranes.
The health beneficial effects of vitamin E are, in part, due to their antioxidant property. Vitamin E is the primary defense against cell membrane and DNA damage and protects LDL and other lipid-rich tissues against oxidation. Vitamin E prevents the oxidation of unsaturated and polyunsaturated fatty acids.
Tocotrienols, due to their unsaturated side chains, provide much stronger antioxidant effects and protect against oxidation of "bad" cholesterol, LDL, which, if oxidized, leads to buildup of plaques in arteries and increased risk of heart attack or stroke. The beneficial effects of tocotrienols also include cholesterol lowering, tumor suppressive effect, and inhibition of blood platelet aggregation.
Reactive oxygen species are of great interest in medicine because of the overwhelming evidence relating them to aging and various disease processes such as atherosclerosis, brain dysfunction, birth defects, cataracts, cancer, immune system decline, rheumatoid arthritis, and inflammatory bowel diseases. A complex antioxidant network, such as vitamin E, is effective to counteract reactive oxygen species that are detrimental to human life.
Research studies have indicated that major diseases that afflict humankind worldwide may be preventable by the intake of nutritional supplements, such as antioxidants. The term "antioxidant" nutritional agent has been applied to a number of specific nutrients; including vitamin E. Antioxidants use therefore has gained popularity to prevent disease and to promote health. These compounds are readily available, and non-toxic.
Antioxidants function by neutralizing the harmful effects of free radicals. Free radicals are unstable, highly reactive molecules that circulate in the bloodstream. Some of these free radicals result from lifestyle factors like environmental stress and strenuous exercise, as well as natural processes like aging. To become chemically stable, free radicals take electrons from other molecules in the body, a process that causes cell damage (oxidative damage). Antioxidants prevent oxidative damage by donating electrons to free radicals. As a fat-soluble vitamin, Vitamin E is amenable for entry and storage in cell membranes to react with free-radical molecules and reduce the damage they cause.
The normal metabolic processes release some free radicals that might cause oxidative damage to our body, but our body repairs most of the oxidative damage caused by these free radicals. However, if we flood our bloodstream with an unusually large number of free radicals, typically by smoking or by eating a high-fat diet, over time, oxidative damage can overwhelm the body's repair mechanisms, setting us up for degenerative diseases. Antioxidants protect cells from the damage caused by free radicals.
Insufficient vitamin E results in free radical mediated lipid peroxidation of membranes and their destruction. Vitamin E protects the skeletal muscles, nervous system, and retina of the eye from oxidation. Vitamin E is essential for normal immune function. Vitamin E mitigates the prostaglandin driven severity of inflammation, PMS and circulatory disorders. Vitamin E may reduce the toxicity of metals and protect against free radical promoting environmental pollutants such as ozone, oxides of nitrogen, drugs, alcohol and smoking. Aging is essentially oxidative deterioration of tissues. Since vitamin E can prevent or slow down reactions of such oxidative damage, vitamin E may slow the aging process. The importance of antioxidants stems from the number of diseases where they play a preventive role, such as heart disease, cancer, and eye disease.
Epidemiological studies suggest that low blood levels of vitamin E are associated with increased risk of development of degenerative diseases including coronary heart disease, Alzheimer's disease, cataracts, and certain types of cancer. Two epidemiological studies of more than 12,000 adults conducted at Harvard University found a 40 percent decrease in heart disease risk in subjects taking at least 100 I.U. of vitamin E daily. However, people taking a higher dose of vitamin E supplements with only alpha-tocopherol may not be realizing full benefit. This is further substantiated by a recent study indicating that gamma-tocopherol traps mutagenic electrophiles such as nitric oxide and complements alpha tocopherol.
Oral doses of vitamin E ranging from 50 to 400 International Units (I.U.) per day did not show any adverse effects in double-blind clinical studies. The recommended daily amount (RDA) is 8 to 10 mg per day for healthy adults. In the U.S., 400 I.U. soft gelatin capsules are the most popular dosage from vitamin E. To achieve the potency of a 400 I.U. capsule, a person needs to consume 450 g of sunflower seeds, 2.2 kg of wheat germ or 1.9 liters of corn oil totaling 8,000 calories daily.
Fat soluble vitamins, like vitamin E, are found in foods associated with lipids and are absorbed from the intestine with dietary fats. Therefore, vitamin E intake is recommended with a meal and normally 20 to 40 percent of the ingested vitamin E is absorbed. Multiple doses instead of a single dose of vitamin E taken daily with a meal seem to indicate increased absorption and utility in the body. In fact, a combination of tocopherols, tocotrienols and phospholipids emulsifier have been shown to be effective carrier of molecules for improved absorption. In cardiovascular clinical studies, 50 mg/day vitamin E was used for a period ranging from 1 to 8.2 years without any adverse effects. Vitamin E is the least toxic among the fat soluble vitamins. No evidence of detrimental effects of vitamin E is observed even at daily doses of 100 to 500 mg. Human studies at daily 240 mg doses of tocotrienols for 18 to 24 months did not indicate any adverse effects. Further animal studies show safety of tocotrienols up to 12,000 mg/day.
Recent research studies have shown that a balanced intake of a full spectrum of vitamin E (gamma-, alpha-, beta- and delta-tocopherols) is the best way to overall health benefits. Research also showed tocotrienols from rice bran to be superior in reducing the atherosclerosis Lesion size in mice, thereby providing a unique approach to promoting cardiovascular health.
Gamma-tocopherol, the principle form of vitamin E in the diet, has been scientifically proven to enhance the health benefits of alpha-tocopherol, and is superior in promoting cardiovascular, brain, and immune health.
Gamma-tocopherol was also found to be superior to alpha-tocopherol in protecting cells against peroxynitrite, a harmful chemical that alters DNA and causes cancer. The study suggested that vitamin E supplement should contain at least 20% gamma-tocopherol.
A nested case-control study involving men who developed prostate cancer and matched control subjects showed that men with high blood levels of gamma tocopherol had a significant reduction in the risk of developing prostate cancer. The study also found a significant protective association for high levels of selenium and alpha tocopherol only in men with high gamma-tocopherol concentration.
In a recent study, gamma-tocopherol and alpha-carotene were found to be significantly lower in plasma of coronary heart disease patients compared to healthy people, suggesting that the plasma level of gamma-tocopherol might represent a marker of atherosclerosis in humans.
In an in vivo study, gamma-tocopherol was found to enhance the bio-potency of alpha-tocopherol. Gamma-Tocopherol induced a marked increase in alpha-tocopherol concentrations in the serum and in nerve tissues, heart, liver, and muscle in rats fed diets containing both gamma-tocopherol and alpha-tocopherol more than those fed a diet containing alpha-tocopherol alone.
In an animal study involving spontaneously hypertensive rats, gamma-Tocotrienol was also found to prevent development of increased blood pressure, to reduce lipid peroxidation in plasma and blood vessels, and to enhance total antioxidant status including superoxide dismutase activity. A recent study also showed that supplementation with 100 mg/day tocotrienol-rich fraction of rice bran for a month resulted in a significant reduction in total cholesterol, LDL-cholesterol and triglycerides.
These studies demonstrated that a composition comprising a full spectrum of all forms of tocopherols and tocotrienols will provide greater health benefits of vitamin E than the only form alpha-tocopherol. New compositions of vitamin E comprising all forms of vitamin E were formulated to meet certain criteria: the desired 400 I.U., higher antioxidant potency than alpha-tocopherol, and comparable cost to the commercially marketed natural vitamin E.
Only recently have reliable analytical methods became available to quantitatively measure the total antioxidant capacities, such as oxygen radical absorbance capacity (ORAC) assay, to evaluate the potency of antioxidant formulations. The ORAC method utilizes a peroxyl radical generator and beta-phycoerythrin protein as an indicator of oxidation by measuring the fluorescence of the protein. The ORAC values are expressed as micromoles of Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-onecarboxylic acid) equivalents per liter of the sample and Trolox shows total inhibition of the peroxyl radical action.
The ORAC assay is a widely accepted method in the world for identifying the antioxidant potential in a sample. The samples can be a pure compound, blood plasma, various tissues and foods such as fruits, vegetables, or dietary supplements. The total antioxidant capacity is reflected from various anti oxidants present in the sample and their interactions. The advantage of this assay is that it helps quantify the antioxidant potential value of a sample compared to other commercial samples.
Several other methods have been developed to measure the total antioxidant capacity of a sample. However, the peroxyl or hydroxyl radicals used in the ORAC assay as pro-oxidants make it different and unique from the other assays that involve oxidants that are not necessarily pro-oxidants. Further, substantial deficiencies of other methods have overcome in the ORAC assay. For example, the ORAC assay was compared to other assays and the ORAC assay seems to provide a better correlation to the antioxidant capacity. Therefore, the ORAC assay method provides a valuable tool with which a researcher can quickly determine the value of a particular antioxidant formulation, where increased potency and reduced cost are desired.
It is an object of the present invention to provide a soft gelatin capsule containing natural vitamin E (d-alpha-tocopherol) blended with an additional vitamin E compounds, specifically natural mixed tocopherols (alpha-, beta-, gamma-, delta-) and tocotrienols (alpha-, beta-, gamma-, delta-), to deliver a potent antioxidant vitamin E with superior oxygen radical absorbance capacity (ORAC) value.
It is a further objective of the present invention to enhance the antioxidant capacity of natural vitamin E (d-alpha-tocopherol) for the specific health benefit derived from supplementation with the novel formulation.
It is a further objective of the present invention to provide a more efficacious product to natural vitamin E (d-alpha-tocopherol) product currently available for consumption.
This invention relates to formulations comprising all forms of natural tocopherols and tocotrienols with enhanced antioxidant activities. These formulations were designed to provide 400 IU, based on one mg d-alpha-tocopherol equals 1.49 IU. The invention further relates to a soft gelatin formulation containing natural vitamin E as d-alpha-tocopherol, mixed tocopherols in the form Alpha, Gamma, Delta, Beta, and tocotrienols, with inseparable tocopherols, in the form of Alpha, Gamma, Delta, Beta. The formulation is contained in a soft gelatin capsule composed of gelatin, glycerin, and water. The formulation is designed to provide antioxidant protection for the cell lipid membrane, and protection against heart disease, cancer, and eye disease.
The antioxidant activities of natural d-alpha-tocopherol, mixed tocopherols and tocotrienols, and formulations comprising all forms of vitamin E were determined employing an improved oxygen radical absorbance capacity (ORAC) assay using fluorescein (FL) as a fluorescent probe, randomly methylated β-cyclodextrin (RMCD) to enhance solubility of lipophilic antioxidants in aqueous medium, 2,2′-azobis (2-amidino-propane) dihydrochloride (AAPH) as peroxyl radical generator, and Trolox as a standard in 75 mM phosphate buffer. The antioxidant activities expressed in μmole Trolox equivalent per gram of d-alpha-tocopherol (87%), mixed tocopherols (70%) and tocotrienols (30%) were found to be 1,293, 1,948 and 1,229; respectively. The data clearly indicate that mixed tocopherols possess higher antioxidant activity than d-alpha-tocopherol.
Vitamin E formulations comprising alpha-, beta-, delta-, and gamma-forms of tocopherols and tocotrienols with enhanced antioxidant activities were developed. All of these formulations provide 400 I.U., based on one mg of d-alpha-tocopherol equals 1.49 I.U. Some of these formulations showed antioxidant activities superior to d-alpha-tocopherol.
This patent discloses formulations comprising all forms of tocopherols and tocotrienols with enhanced antioxidant activities. These formulations provide 400 I.U., based on one mg d-alpha-tocopherol equals 1.49 I.U. Novel formulations of vitamin E comprising a full spectrum of all forms of vitamin E, which possess significantly higher antioxidant activity than alpha-tocopherol are disclosed.
Other features and advantages of the present invention will become more apparent from the following detailed description, which illustrate, by way of example, the principles of the invention.
The antioxidant activity, commonly referred to as oxygen radical absorbance capacity (ORAC), of a lipophilic substance was measured employing a newly developed assay. This assay is based on the use of: (a) fluorescein (FL) as the fluorescent probe, (b) randomly methylated β-cyclodextrin (RMCD) as a molecular host to enhance the solubility of lipophilic antioxidants in aqueous solution, (c) 2,2′-azobis (2-amidino-propane) dihydrochloride (AAPH) as a peroxyl radical generator, and (d) 6-hydroxy-2,5,7,8-tetramethyl-2-carboxylic acid (Trolox) as a standard in 75 mM phosphate buffer (pH 7.4).
The antioxidant activities of vitamin E formulations comprising all compounds of tocopherols and tocotrienols were determined employing an improved oxygen radical absorbance capacity (abbreviated ORACFL-LIPO) assay using fluorescein (FL) as the fluorescent probe, randomly methylated P-cyclodextrin (RMCD) as the water solubility enhancer for lipophilic antioxidants in 75 mM phosphate buffer (pH 7.4).
In the presence of peroxyl radicals derived from AAPH, the indicator FL gradually loses its fluorescence. The antioxidant activity of a substance is measured by its ability to retain the fluorescence of FL in the presence of peroxyl radicals. The net protection of FL was measured as previously described by Ou et al.
Chemicals and Apparatus
Randomly methylated β-cyclodextrin (RMCD) was purchased from Cyclolab R&D Ltd. (Budapest, Hungary). Fluorescein (FL) and 6-hydroxy-2,5,7,8-tetramethyl-2-carboxylic acid (Trolox) were purchased from Aldrich (Milwaukee, Wis.). 2,2′-azobis (2-amidino-propane) dihydrochloride (AAPH) was obtained from Wako Chemicals USA (Richmond, Va.). 87% d-alpha-Tocopherol (containing 13% soy bean oil) and 70% mixed tocopherols (containing 30% soy bean oil) were purchased from Archer Daniels Midland. Each gram of 70% mixed tocopherols contains 114 mg d-alpha-tocopherol, 11 mg d-beta-tocopherol, 457 mg d-gamma-tocopherol, and 131 mg d-delta-tocopherol.
Tocotrienols oil was purchased from Oryza Oil and Fat Chemical Co. in Japan. Tocotrienols oil contains 35% total tocopherols and tocotrienols (12.6% gamma-tocotrienol, 7.2% alpha-tocotrienol, and 12.7% alpha-tocopherol). Palm oil containing 50% total tocopherols and tocotrienols (10% alpha-tocopherol, 11% alpha-tocotrienol, 20% gamma-tocotrienol, and others) was obtained from Carotech (Edison, N.J.).
All other standards were commercially available form Sigma or Aldrich. All ORAC analyses were performed on a COBAS FARA II analyzer (Roche Diagnostic System Inc., Branchburg, N.J.) using an excitation wavelength of 493 nm and an emission filter of 515 nm.
Sample Preparation
Approximately 0.5 g of sample was dissolved in 20 mL of acetone. An aliquot of sample solution was appropriately diluted with 7% RMCD solvent (w/v) made in a 50% acetone-water mixture (v/v) and was shaken for 1 hr at room temperature on an orbital shaker at 400 rpm. The sample solution was ready for analysis after further dilution with 7% RMCD solvent.
Automatic ORAC Assay
The automated ORAC assay was carried out on a COBAS FARA II spectrofluorometer centrifugal analyzer as previously described (9). With the exception of samples and Trolox standards, which were made in 7% RMCD solvent, all other reagents were prepared at 75 mM phosphate buffer (pH 7.4). In the final assay mixture (0.4 mL total volume), FL (6.3×10−8 M) was used as a target of free radical attack and AAPH (1.28×10−2 M) was used as a peroxyl radical generator. 7% RMCD was used as the blank, and Trolox (12.5, 25, 50, and 100 μM) was used as the control standard. The analyzer was programmed to record the fluorescence of FL every minute after the addition of AAPH. All measurements were expressed relative to the initial reading. Final results were calculated using the differences of areas under the FL decay curves between the blank and a sample. These results were expressed as micromoles Trolox equivalent (TE) per gram, as previously described by Ou et al.
The antioxidant activity, commonly referred to as oxygen radical absorbance capacity (ORAC), of a lipophilic substance was measured employing a newly developed assay. This assay is based on the use of: (a) fluorescein (FL) as the fluorescent probe, (b) randomly methylated P-cyclodextrin (RMCD) as a molecular host to enhance the solubility of lipophilic antioxidants in aqueous solution, (c) 2,2′-azobis (2-amidino-propane) dihydrochloride (AAPH) as a peroxyl radical generator, and (d) 6-hydroxy-2,5,7,8-tetramethyl-2-carboxylic acid (Trolox) as a standard in 75 mM phosphate buffer (pH 7.4).
In the presence of peroxyl radicals derived from AAPH, the indicator FL gradually loses its fluorescence. The antioxidant activity of a substance is measured by its ability to retain the fluorescence of FL in the presence of peroxyl radicals. The net protection of FL was determined as previously described by Ou et al.
The ORAC value was calculated as μmole Trolox equivalent per gram sample (μmole TE/g); one gram of sample has antioxidant activity equals to how many μmole Trolox. The μmole Trolox equivalent per 400 I.U. of the sample is calculated as follows:
Tables (1) and (2) list the ORAC data expressed in μmole Trolox equivalent (TE) per gram of tested antioxidant sample. The formulations in Table (2) differ from those in Table (1) in that the Table (2) formulations further include Palm Oil and there is a slight modification in the ingredients of Formula 2 in Table (2) as compared to Formula 2 in Table (1). The results of data in Table (1) showed that the synthetic vitamin E acetate showed no antioxidant activity under current experimental conditions, supporting the essential role of the phenolic type hydroxyl for radical trapping antioxidant activity of vitamin E.
The IUs (International Unit) of a sample are based on one mg of alpha-tocopherol equals 1.49 IU.
The following are the percentage of alpha-tocopherol and the corresponding IUs in each ingredient used in the formulations listed in Tables (1) and (2):
(a) Natural vitamin E contains 87% alpha-tocopherol, which means that each gram of natural E contains 870 mg alpha-tocopherol×1.49=1300 IU, i.e. natural vitamin E contains 1300 IU per gram
(b) 90% Mixed tocopherols contains 6.8% alpha-tocopherol, which means one gram of 90% mixed tocopherols contains 68 mg alpha-tocopherol×1.49=101 IU, i.e. 90% mixed tocopherols contains 101 IU per gram
(c) 70% Mixed tocopherols contains 11.4% alpha-tocopherol, which means one gram of 70% mixed tocopherols contains 114 mg alpha-tocopherol×1.49=170 IU, i.e. 70% mixed tocopherols contains 170 IU per gram
(d) 30% Tocotrienols (Oryza) contains 13% alpha-tocopherol, which means one gram of 30% tocotrienols contains 130 mg alpha-tocopherol×1.49=200 IU, i.e. 30% tocotrienols contains 200 IU per gram
(e) 50% Tocotrienols (Carotech) contains 10% alpha-tocopherol, which means one gram of 50% tocotrienols contains 10 mg alpha-tocopherol×1.49=150 IU, i.e. 50% tocotrienols contains 150 IU per gram
Data in table (1) revealed that alpha-tocopherol (87%) had a value of 1,293 μmole Trolox equivalent (TE) per gram, from this data one can calculate the μmole TE of 400 I.U. of alpha-tocopherol (87%) to be 398 (307.7 mg alpha-tocopherol is equivalent to 400 I.U.). Similarly, the μmole TE per 400 I.U. of each vitamin E formula can be calculated, and the results are given in table (1). As can be seen from data in table (1), the antioxidant activities of natural vitamin E formulae 1, 2 and 3 are higher than that of natural d-alpha-tocopherol (87%) at its specific concentration in the specified formula. Similar relative antioxidant activities were also obtained with tocotrienols from either Palm Oil or Oryza Oil as shown by the formulations in Table (2). These results indicate that the various isomers of natural tocopherols and tocotrienols could enhance the antioxidant activity of natural vitamin E (d-alpha-tocopherol). A recent study showed that a combination of alpha-, gamma-, and delta-tocopherols in a concentration found in nature is more potent than alpha-, gamma-, and delta-tocopherol alone in enhancing nitric oxide release, and inhibiting human platelet aggregation and lipid peroxidation.
The biological activity of vitamin E has generally been associated with its well-defined antioxidant property, specifically against lipid peroxidation in biological membranes. Therefore, it is anticipated that enhancing the antioxidant property of vitamin E as well as the full spectrum of various vitamin E forms might provide better health benefits than just alpha-tocopherol.
The antioxidant activities of alpha-tocopherol, mixed tocopherol and tocotrienols, and vitamin E formulations comprising all forms of tocopherols and tocotrienols were determined employing an oxygen radical absorbance capacity assay suitable for lipophilic antioxidants. The results of this study clearly indicate that mixed tocopherols possess higher antioxidant activity than d-alpha-tocopherol.
Vitamin E formulations, providing 400 I.U., comprising various forms of tocopherols and tocotrienols with enhanced antioxidant activities were developed. Some of these formulations showed antioxidant activities superior to d-alpha-tocopherol.
Formula-1 and Formula-2 were found to possess a much higher ORAC value than that of natural vitamin E (d-alpha-tocopherol). Formula-3 also showed an increase (25%) in its antioxidant activity as compared to alpha-tocopherol. Formula-4 showed slightly higher antioxidant activity that alpha-tocopherol. Formulae-1, -2, -3 contain alpha-tocopherol, mixed-tocopherols and tocotrienols, whereas Formula-4 contains only alpha-tocopherol and tocotrienols. As mentioned above, mixed tocopherols provide additional health benefits, therefore, Formula-1 or Formula-2 would be recommended since they contain all natural mixed tocopherols and tocotrienols and possess significantly higher antioxidant activity than alpha-tocopherol, and their cost is comparable to the widely marketed natural d-alpha-tocopherol. Each gram of 70% mixed tocopherols contains 114 mg d-alpha-tocopherol, 11 mg d-beta-tocopherol, 457 mg d-gamma-tocopherol, and 131 mg d-delta-tocopherol. From these data, the amount of gamma-tocopherol in
Formula-1 and Formula-2 is calculated to be 24% and 21%; respectively. These values are in accordance with the recommended amounts of gamma-tocopherol in vitamin B supplement. This study was published in Proceedings of the national Academy of Science, USA (1997), and suggested that vitamin E supplement should have at least 20% gamma-tocopherol. Formula-3, on the other hand, contains only 9% gamma-tocopherol.
In one preferred embodiment, the invention comprises a composition of natural vitamin E with enhanced antioxidant activity, comprising: (a) 55 to 85% by weight of d-alpha-tocopherol; (b) 10 to 40% by weight of mixed tocopherols; and (c) 2 to 3% by weight of tocotrienols. In another embodiment, the mixed tocopherols comprise 70% tocopherols in the amounts of 5 to 15% alpha-tocopherol, 1 to 3% beta-tocopherol, 30 to 50% gamma-tocopherol, and 10 to 20% delta-tocopherol. In another embodiment, the mixed tocopherols comprise 90% tocopherols in the amounts of 10 to 20% alpha-tocopherol, 2 to 4% beta-tocopherol, 50 to 80% gamma-tocopherol, and 10 to 20% delta-tocopherol. In another embodiment, the tocotrienols are obtained from rice oil and said tocotrienols contain 10 to 15% alpha-tocopherol, 10 to 12% alpha-tocotrienol, 10 to 12% gamma-tocotrienol, and 2 to 10% other tocopherols and tocotrienols. In another embodiment, the tocotrienols are obtained from palm oil and said tocotrienols contain 8 to 14% alpha-tocopherol, 8 to 14% alpha-tocotrienol, 15 to 30% gamma-tocotrienol, and 5 to 10% delta-tocotrienol.
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Have you looked at a photo and wished you were there, or wondered what the scene looked like to the photographer? Now you can bring your photos to life by adding motion and depth to your images. Author Rich Harrington reveals how you can transport your photos into a three-dimensional world using Adobe Photoshop and After Effects. The course shows you how to select the right images and resolutions; how to use masks and layers to build the composition in Photoshop; and how to animate the camera and light the scene in After Effects.
Once you've set up the initial comp with the layered files and you've added the 3D camera into the scene, it's time to start to extrude layers into 3D space. Essentially, you're using the Z axis, and in 3D animation terms, it's often explained like this. We've got our X axis that can move things along horizontally, the Y axis, which does vertical, and the Z axis, which goes in and out. I've actually seen animators label their fingers to make this easier, but that's essentially all it is, is a three-axis movement.
We're going to go ahead and start to move these layers along the Z axis to expand them, and this will create the sense of depth that leads to parallax once the camera is animated. Now, I'm going to duplicate these layers here and press Ctrl+D, and now I've got a new stage. Let's just open those up, and we'll close these Stage 1 Files. This is a good idea as you first start to design because it creates a safety net or a series of breadcrumbs, so you can go backwards in time and look at what you've been doing. So if I mess up Stage 2, I can resume my work with Stage 1, and I'll just save the project.
All right, let's start with this nice, simple file here. I've got my camera and my layers. What I need to do is set this to 2 Views to make this a bit simpler. And on the left, I see the view from the Top, and the right is the Active Camera View. If these don't match on your system, you have the ability to change them with the pop-up menu. I'm going to take this one labeled Top and choose Custom View 1, which many refer to as a God view.
It's about 45 degrees to the left and 45 degrees up, and it lets you look down on your set like the director. And with the layer selected, I could press P for Position. We have the X, Y, and Z axis. Now, what's going to happen is is you're going to push layers further away. So as I move the brick further away, it goes back in space. However, looking at the image here, it doesn't look right.
I'm going to now press Shift+S to add the Scale Property and scale that back up. And you know you've scaled it to the right size when it touches the edge of the frame. Let's go ahead in this case and pull the bush forward towards the camera, and then Shift+S for Scale, and I can scale that down just a little bit, there we go.
Okay, we've adjusted the size of those. Now, when you move something closer to the camera, you have to scale it down so it looks right. When you move it further away, you have to scale it up. This is where that Reference layer comes in. You could toggle that Reference layer off and on to compare it. In this case, it's pretty close. It looks like the background layer needs to be maybe one pixel bigger. So I'll go ahead and select the Scale Property, and I'll hold down the Alt key here as I drag, Option on a Mac, just to scale that down a bit.
That looks good! Turn the Reference off and on, and notice there, very minimal difference between the two, that's good enough. Once satisfied, I could throw away the Reference layer or leave it around, it's up to you. I'll just go ahead and hide it there, and that looks pretty good. Let's repeat that process for this other document. We'll go with 2 Views, change one of the views to Custom View 1.
Using the Comma keys I could zoom in and out, and I'm going to go ahead and push the field further away. Now, this should be really far away, because it is really far away. As for scale, scale that up so it touches the edge. Now, the tent should be a little bit farther back. So P for Position, I'll move it back a small amount, and then holding down the Shift Key, press S for Scale, and scale that up.
That looks pretty good! If I look at the virtual set here, I can get a good idea what's happening. You also may decide to change the colors here, and this makes it easier in certain views to see what you're doing. For example, if you set this to Top View and zoom out, you get a good idea of the different layers. For example, the yellow layer here is the field, the red layer is the tent, and the purple layer is the soldiers, and this helps you understand the relative distance between the different objects as you position them along the Z axis.
When satisfied, I'll just flip that back to Custom View 1, and I could zoom in and take a look at my set. Remember, the Comma key and the Plus key are useful because you could zoom in and out. Holding down the spacebar you could pan the window to frame it up how you need to, to design your frames. Now that we've got all the layers positioned and the cameras placed, we just need to size the composition for proper output.
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Pharma & Biotech Tap into Mobile Apps
Drug companies are piloting Apps on both iPhones and iPads. One of the most interesting is a form of disease-specific Personal Health Record. These can collect patient-specific data about disease episodes, medications, dosing and compliance. They have the opportunity to become tools through which drug manufacturers can drive, or at least influence compliance. It is a little too early to say if these Apps will successfully drive compliance. However if they do, then they are a very interesting new competitive tool that all drug companies need to be aware of, as they would own the patient data, have direct access to the patient through the App and potentially significantly increase sales.
A CI-Strategy survey of the top 100 pharma and biotech companies in September 2012 shows that these companies are testing mobile Apps with a number of launches in 2011 and 2012 and, presumably, many more in the pipeline.
To date, only 30%, or 30 companies out of the 100 surveyed have Apps in the Apple Apps Store. Both big and mid-sized manufacturers have Apps. Some Apps are sponsored by country subsidiaries of US and European firms, such as in Australia, South Korea and Japan, implying that either the local management in these countries has got the go-ahead to be test pilots, or have gone it alone being more entrepreneurial than their US and European counterparts.
The 30 companies with Apps had launched 101 Apps at the time of this survey. Nearly two thirds have only launched one or two Apps. The largest number of Apps sponsored by any one single company is nine – Merck and Sanofi.
Some 20% are reported to be in multiple languages.
All are free whether for the iPhone or iPad. The iPhone is the most popular platform accounting for 75% of all Apps, 50% are on the iPad and 25% are on both platforms.
These Apps are targeted at either consumers (patients), or professionals (providers). Nearly two thirds are aimed at consumers, while one third at professionals.
The most interesting insights to come out of this survey are around the target usage of these Apps.
Nearly 40% of the Apps is aimed at consumers have functionality similar to Personal Health Records (PHR), but specialized for a specific disease state – migraine, hemophilia, psoriasis, diabetes, baby nutrition. The intent is for the user (patient or care giver) to enter details of the patient's condition over time (instances of migraines or outbreaks of psoriasis), as well as their intensity and other relevant details. In many of these Apps, users can also enter details of therapy compliance (pills taken and when).
PHRs have not taken off to date. Attempts by both Google and Microsoft to get into this market a few years back failed badly. However, it makes tremendous sense for drug manufacturers to try to get their customers to use these disease specific PHR Apps. With drug compliance levels often dropping to 30% after the first year, if drug companies can use these Apps to drive compliance, such as by sending out reminders to get refills if they see patients falling off their regimen, these Apps will more than pay for the time and effort to build and maintain them.
However, one has to question why patients would use these disease specific PHRs without an incentive. Having your phone remind you every morning to take your pill will soon become annoying and easily ignored. The segment of the market that could give incentives is the health plans as better compliance should lead to healthier plan members and more data should help them drive wellness. But health plans have yet to develop Apps with this functionality. So for the time being, it is up to drug companies to develop clear benefits to Apps users around regularly filling in their personal disease and medication data and having these Apps remind them to take their medication. Perhaps drug companies could offer special electronic coupon redeemable at pharmacies, or links to disease specific crowd sourcing websites like PatientsLikeMe.com.
Other consumer App functionality is aimed at helping patients get fitter or lose weight, while others provide education on specific diseases, or where to find the company's product. There are also Apps that help patients self-diagnose or provide updates on the environment, like levels of UV or flu. These all help to build brand image for specific companies or drugs.
In the professional segment, the main application is education, accounting for half the Apps, with the second being dosing and risk calculators. However much of this information is likely to be available via independent Apps like Epocrates, which is already widely used by physicians. Admittedly, full access to Epocrates costs $200 plus a year, but it would seem a small price for a professional to pay to have all the information he or she needs via a single App. The third area of Apps for professionals is an up to date list of congresses. This too is available through a number of different Apps so it would seem that the issue the drug sponsored Apps to professions may have is that they compete against Apps from either independent publishers like Epocrates or WebMD¸ or other drug companies.
There would seem to be real competitive value in consumer PHR-like Apps if drug companies can find ways to keep consumers using them. However, the functionality of many of the other Apps would seem to be nice-to-have with the value more around building brand image rather than revenue generation.
It is very early days for the drug company sponsored mobile Apps and it will be very interesting to see how their functionality evolves.
by Mike Ratcliffe
4 Comments
ehSeptember 24, 2012
Very interesting findings – have you also seen this recent social media game created game by Boehringer Ingelheim ? I wonder who else will follow suit:
mikeratcliffeSeptember 24, 2012
I have, but I'm not sure I understand exactly what its goals are. The trailer talks about "education," but I assume its more. Since it will not be launched until 2013, I have only the trailer to go on. If anyone has any more insight I'd be very interested.
Only 30% of Top 100 Pharma and Biotech have Apps… « Science Intelligence and InfoProsOctober 1, 2012
[...] Ratcliffe, Mike. Pharma & Biotech tap into Mobile Apps. CI Strategy, 21 September 2012, Available from: http://www.cistrategy.com/2012/09/21/pharma-biotech-tap-into-mobile-apps/ [...]
CI-Strategy » Pharma & Biotech Tap into Mobile Apps | i-Pharma Digital | Scoop.itOctober 2, 2012
[...] [...]


text: Wat voor hulp heeft u nodig? (Voorbeelden:"installatie Panda Security 2013", "Ik wil contact opnemen met Panda") Tweet What is the Panda Account included in Panda Gold Protection 2014 and how do I set it up? Informatie van toepassing op: Products Panda Gold Protection 2014Your Panda Account is an exclusive area available for all Panda Gold Protection clients which allows to:Download your products.Manage the services of your product, find out the expiry date, renew the license, etc.Obtain the specific documentation of your product.Report issues of your product to Technical Support.To create your Panda Account, just follow the Panda Gold Protection installation wizard through. We highly advise you to do it this way, as your account details will be automatically associated to the Activation Code of your product.You can also create your account outside the installation of Panda Gold Protection. However, bear in mind that you will need to associate the product´s activation code to your Panda Account manually afterwards.This is how you do it.Step 1: Create your Panda accountAccess Panda Account by clicking the link below:https://myaccount.pandasecurity.com/Click Create new account to sign up.Fill in the Email address, Password, Confirm password, Country and click Create.You will get confirmation that the account has been correctly created.All you need to do at this point is verify the email address you entered during the signing up process.Step 2: Activate your Panda accountAccess your inbox, open the email sent by Panda Security and click the Activate your account! button.Once your account is activated, you can confirm your data. This step is optional. Enter your data or, if you prefer to do it later on, press Not now.Step 3: Add your productsThe last step of the Panda Account creation wizard after activating the account will take you straight to the section called My Products within your Panda Account. The same applies after logging in your newly created account.In any case, once in My Products, you need to associate your Panda Gold Protection to your Panda Account. To do so, follow the steps below:Click +Add first in the You still haven´t registered any products window.Now, add the Activation Code of your product.That´s it! Now, you are all set to access your Panda Account and start enjoying all the benefits it offers!Additional InformationHow do I access my Panda Account?How do I change my Panda Account details? Artikelnummer- 20140616 80768 EN Help ons om onze dienstverlening te verbeteren. Geef ons uw mening! Uw suggesties zullen ons helpen om uw vragen sneller en effectiever te beantwoorden. Gaf dit artikel het antwoord op uw vraag? JA NEE Hartelijk dank voor uw antwoord Hoe zou u dit artikel verbeterd willen zien? Wilt u contact opnemen met onze technische ondersteuning?


text: I hope you had a Happy Darwin Day! Last Sunday was Evolution Sunday, and so my Sunday school class focused on that topic, spending time clearing up misconceptions about what evolution says, and explaining why evolution is no more incompatible with religious faith than any other area of science. I highlighted that the claim that [Read More...]


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Tags underground hip hop, old school hip hop, old school rap
Artists Kankick, Shabazz Palaces, Dynamic Syncopation
April 07, 2012
Ohio Drives. Stoned. Garage-ish Tunes. by Cullin Bah
A collection of the music I've been listening to on my many drives through Ohio.
the almighty defenders, indie rock, low-fi, garage, 60's
Lazy Summer Weekday Porch Nights by Cullin Bah
I think the title will also double as a description .
indie, garage/rock, 60's, chilled, psychedelic indie rock
Hip-Hop, Underground, Realness. Word. by Cullin Bah
underground hip hop, old school hip hop, old school rap
Spring Hums. by Cullin Bah
jens lekman, junip, bonnie prince billy, twin sister


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Headline News - Feb. 7
Today's top three stories from around the soccer world
February 7, 2012
With Jay Heaps now at the helm for the Revolution, Zack Schilawski is excited about the possibility of being more involved in the attack this season. Kyle McCarthy takes a look at what lies ahead for the third year player on MLSsoccer.com.
Since returning from the team's first preseason stint in Arizona, the Revolution have brought in five new trialists. Sean Donahue takes a look at each of the players' backgrounds in his piece for New England Soccer Today..
Franco Panizo of Soccer By Ives looks at some moves around MLS this past week. D.C. United and the New York Red Bulls added some key players as preseason pushes on.


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Keeping fingers crossed, hoping for a better future
Tabu Enike, 16 years old
"The biggest thing I will celebrate in our first year of independence is the restoration of peace. Freedom is like a dark cloud that has been lifted over our heads. Being free means everything to me. Now there are streets lights and we are now free to walk outside in the evening."
Tabu Enike, 16, is studying hard and wants to become a government minister. Tabu wants to play a part in the governance of her country, still troubled after many years of civil war.
"Ministers are the decision makers and I know therefore that if I was to be a minister in parliament I would be able to, for example, help orphans and poor people, especially children", she says.
Free education, career prospects and freedom are just some of the things South Sudan's youth are celebrating as the first anniversary of the newly independent state approaches.
Children and youth in the world's newly independent country are optimistic, despite dire economic and political forecasts for the troubled infant state. They say they have their fingers crossed for a better future, according to an opinion poll conducted by Plan South Sudan.
Adam Modi, 16 years old
"If the new government does not help my father, then I will have to do it myself when I become an optician. I also want to help other people who cannot access adequate healthcare."
Adam Modi, 16, a grade seven pupil at Gudele Model Primary School in South Sudan's capital Juba, is clear about his future prospects – he wants to become an optician. Adam's father is half blind and the fact that he has not been able to get medical services for many years has bothered Adam all his life.
He explains: "My father visited many hospitals a few years ago, but his efforts came to nothing due to more than two decades of civil war that dashed any hopes for decent medical care in this country. My father gave up seeking medical help and he learnt to live with the fact that he is half blind.".
But as South Sudan celebrates its first year of independence, Adam is cautiously optimistic that finally his father might regain full sight as the government moves, albeit at a slow pace, to shore up the health delivery service in the country of more than eight million people.
For Adam, good healthcare is a top priority and he is dedicating his life to ensuring that this will be a reality. He also feels that good infrastructure, education and security are key to the growth and development of South Sudan.
"I now know my rights as a child, thanks to Plan International", adds Adam. "Through the child rights and child protection training that I received from Plan on several occasions, I now know what I am entitled to as a citizen."
John Soro, 21 years old
"The government has brought free education since independence and this has allowed me to come back to school. Knowledge is the key to changing South Sudan."
John Soro, 21, should be in his third year at university but is still in year six at Mirikio Primary School. John is just but one of a plethora of young South Sudanese who are celebrating the fact that they are now able to return to school.
During more than two decades of civil war, schools were destroyed and many young people were forced to join the war as child soldiers. Others fled the country into neighbouring states where they were housed in refugee camps with little or no education facilities. South Sudan has one of the world lowest literacy rates at just 27%.
"I applaud non-governmental organizations such as Plan International for complementing government efforts in the area of education by building classrooms," says John.
He is unfazed that at 21 he is still in primary school.
"Just as my country has also gotten independence late, I will also have to make sure I succeed," he adds.
Many others are hopeful
Other young people and children who took part in the opinion poll, involving more than 50 children and youth in South Sudan, hope to find jobs after completing their education, but the prospects of transitioning into the job market remain hollow unless the economy grows.
Hilde Johnson, the United Nations Special Representative to South Sudan this week said: "The situation in South Sudan remains dire unless the international community unlocks more financial support to the country and unless oil production is resumed. Security is also key to the success of South Sudan".
Acting Country Director in Plan South Sudan, Gerald Magashi, says for South Sudan to realise long term peace and stability, the country needs to concentrate its efforts on building the capacity of the youth – but says there are grave threats to security due to the troubled relationship between North and South Sudan.
"The high hopes for the world's newest nation have yet to materialise. One year on from independence, South Sudan is facing violent conflict with its northern neighbour, Sudan - while struggling to cope with an influx of returnees with unaccompanied children fleeing the north and an unfolding food crisis.
"If we want long term peace and stability in the region we need to concentrate our efforts building the capacity of the youth. The international community must invest in giving young people skills and jobs. Viable and stable livelihoods will help this new generation build their own country, and steer them away from the risks of inter-ethnic fighting," says Gerald.


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Students from Mt. Hood Community College (Ore.) are collecting seeds from native plants that blanket the forest floor and will transplant them to baron locations to ensure their future survival.
Read more
Campus infighting, perceptions of cultural insensitivity, and inadequate counseling are just some of the reasons the Accrediting Commission for Community and Junior Colleges gave Los Angeles Mission College's Sylmar campus a warning recently for "academic and administrative deficiencies."
East Bay community colleges are beginning to reap the benefits of the passage of last November's Proposition 30. The tax initiative is helping to make more classes available to students; something they haven't seen in a long time.
In this month's Future Shock column (University Business, July 2013), James Martin and James E. Samels talk about the educations in criminal justice, nanotechnology, biotechnology, and forensic science that Boston's first responders received at schools such as Middlesex Community College and UMass Lowell. It was these studies that, in part, helped them bring the Boston bomber to justice.
Planning for technology-rich learning spaces takes enormous amounts of time, effort and funding. Here are eight tips from Central Oregon Community College and other higher ed institutions that have done it successfully.
Stable funding of federal Pell Grants, one of the nation's main financial aid programs for low-income students, would increase affordability and accessibility, according to many groups with a stake in higher education. But the program faces perennial threats to its funding.
Nearly one in five community college students get so worried about finances, they think about dropping out, according to the "Inceptia National Financial Aptitude Analysis" report. Teaching them to better manage money may help them graduate.
Coastline Community College faculty would teach on-site entrepreneurship and small-business management classes to prisoners in the Navy brig at Marine Corps Air Station Miramar, about 10 miles north of downtown San Diego.
Los Angeles Mission College President Monte Perez had shut off his smartphone and sat down for a late afternoon movie when he had a bad feeling about the accreditation of his campus.
Joliet Junior College officials are seeking to issue $45 million in bonds that would go to construction of a multipurpose facility at the main campus and an expansion of the Romeoville campus.


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Below is the poem entitled THE OGRE IN THE GARBAGE DISPOSAL which was written by poet
Perez. Please feel free to comment on this poem. However, please remember, PoetrySoup is a place of encouragement and growth.
Read Poems by
Nola Perez
He likes an egg
without a shell, cracked
by the careless act
of a grocery store clerk.
There's always some jerk
who could make you sick
then read your obit
with a pained expression
as if that session
and consequence grim
had nothing to do
with him.
The Og. loves
is always ready
when you've got
a question
of indigestion.
He loves a meal
of apple peel
(forgive me Giuseppi
of the Pinnochio
story). I do not care
for apple peel,
and though the Og.
is small, he
gobbles it all.
A comment has not been posted for this poem. Encourage a poet by being the first to comment.


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ST. LOUIS, MO (KTVI) – For the first time ever, Southern Living and CMT are partnering to celebrate two of America`s favorite things. Allison De Marcus is the host of Reel Eats and the wife of Rascal Flatts` Jay Demarcus. She is also the author of a new book, Southern Living Country Music's Greatest Eats.
More: CMT.com


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A Welcome from Northeast Animal Hospital in St. Peterburg FL
Located in Saint Petersburg, Florida, Northeast Animal Hospital is dedicated to providing quality, friendly care to the pets of Pinellas County and Northeast Saint Petersburg for over 40 years.
We are proud of our hospital and the many state-of-the-art services we offer. Our specialty services include laser surgery, digital imaging, ultrasound, laboratory testing, videoscopy, cold laser and stem cell therapies, behavioral assistance, boarding and bathing services and more. We also offer all natural foods.
Our patients include common companion pets, dogs and cats and also some more exotic pet animals, such as birds, rabbits, ferrets, guinea pigs and other pocket pets.
Each veterinarian and team member is genuinely committed to the health and well-being of your pet. We love animals as much as you do!
When you choose the right vet for you and your animals, look to Northeast Animal Hospital.
Our Mission at Northeast Animal Hospital
Our mission at Northeast Animal Hospital is to fulfill the needs of our clients and patients by providing quality veterinary animal health care services through a responsive, professional veterinary staff with the emphasis on individual attention and remembering to treat every pet as if they were our own.
Northeast Animal Hospital Provides Exotic Veterinary Pet Healthcare
If you are looking for the right veterinarian for your exotic pet, we invite you to look at Northeast Animal Hospital here in St. Petersburg FL.
In addition to cats and dogs, our veterinary services also include the treatmernt of birds, pocket pets, ferrets, Guinea pigs and even reptiles.
Our veterinarians are able to perform preventative care as well as treatments and emergency care.
Give us a call to schedule your exotic pet for a check-up today!
What Makes This Animal Hospital Unique
Northeast Animal Hospital is a contemporary veterinary animal hospital with multiple services, all under one roof. Our veterinary hospital is equipped with the latest technology, including laser surgery, ultrasound, stem cell therapy and videoscopy.
We also provide cutting edge pain management which includes Stem Cell Therapy and Cold Laser Therapy.
Our trained and licensed veterinary nurses, as well as our professional pet care coordinators, are always available to provide superior veterinary care for your pet.
Northeast Animal Hospital Provides Online Pet Medical Records
Our online E-Pet Health option is your pet's own medical history at your fingertips.
Manage your pet's healthcare: request medications, make appointments, communicate with us online and learn more about your pet's individual health.
Monthly Focus Topic
This month we are focusing on the relationship between having children and pets in the home and part of the family structure. You will find guidelines and important information about this special human animal bond.


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True Blood
Spoiler Etiquette PSA From Nelsan Ellis and More TV Stars (VIDEO)
We always try to watch True Blood live, but in those rare cases, we can't, there's nothing worse (NOTHING) than hearing or reading a spoiler. We've all been there, either as person who got spoiled or did the spoiling. Check out some spoiler etiquette tips in this funny College Humor video featuring Nelsan Ellis, Julie Benz (Dexter), Sarah Wayne Callies (The Walking Dead), Masi Oka (Heroes), and more TV stars.


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Recent Posts
Recent Comments
- Ben on For You Tube…
- smack on For You Tube…
- esmark on New Stag Single!!!
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- The Yak on Play On
Tag Archives: Fillmore
All Music Review
Steve Mack (That Petrol Emotion)'s cool, enthusiastic voice hasn't changed, and this new Seattle five-piece, including songwriter/guitarist Ben London (ex-Alcohol Funnycar), tries a more classic rock-pop song, and a good one, than either older group was known for. With Seattle … Continue reading
Posted in News Tagged alcohol Funnycar, All Music, Ben London, Cesar, Fillmore, Fin Records, Rovi, Stag, Steve Mack, That Petrol Emotion, The Who Leave a comment


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Best Titan Poker Bonus Code for First Timers
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Don't miss this chance to scoop up some free money while enjoying world-class poker. Download Titan Poker and use our TPDEAL Titan Poker bonus code today.


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the links to see her naked movie clips at Mr
Secrets 2004
00:59:00 With a no-nonsense air, La Bellucci
peels for a cavity searcher. Sadly, we don't actually see her cavities,
but her phenomenal funbags are out and loud and proud. (18
& Obélix: Mission Cléopâtre 2002
00:56:00 We see Cléopâtre's
buns in the milkbath. (56 seconds)
00:50:00 Some flashes of Monica's ass
following a brutal rape scene... (71 seconds)
01:17:00 A nice look at Bellucci's bumper
while she lays on top of Cassel in bed. (27 seconds)
01:18:00 Yet more T&A, as well as
a couple of ultra-brief flashes of Monica's Landing Strip in bed with
Vince... (114 seconds)
01:23:00 Cassel puts a bit of the Attack
on Monica's Rack while they spend some more quality time in bed... (78
01:25:00 Another glimpse or two of Monica's
mammaries while she takes a shower... (57 seconds)
Brotherhood of the Wolf 2001
00:39:00 Brief view of Bellucci's beautiful
bunnage as she rides Le Bihan. (55 seconds)
00:42:00 Long shot of her naked form then
close-ups of breast and buns lying in bed with Samuel Le Bihan. (28
00:15:00 Beautiful Bellucci wears a sexy
black dress that eventually slips below her right nipple. Mama mia,
that's a spicy meata-ball! (19 seconds)
00:20:00 UNCUT EURO VERSION: The world's
luckiest child actor takes off Monica's dress and bra, then takes a
nice close-up look at her awesome tits and thick bush. (13
00:28:00 First she's in a dress... then
she's naked! Then she's back in the dress! Weird. Nice ass, though.
(7 seconds)
00:56:00 Brief left nip as she gets tossed
around by a lawyer looking to settle his bill... the old fashioned way.
(7 seconds)
01:08:00 It's time for a wash, and so
we see Belucci's boombooms being soaped up but good. Then she pours
fresh squeezed lemon juice all over them... Delicioso! (31
01:10:00 Another scene, another shot of
boobs... Not that we have a problem with that. This time Belucci shows
her fine rack when she's forced into some sex by a happy old dude. (21
01:14:00 Now an Aryan blond, Monica rides
some Nazi dude in a brief kaleidoscopic dream sequence. Ein gut breaschts!
(13 seconds)
01:19:00 Though this scene starts out
with Elisa Morucci, it changes quickly into Bellucci, just long enough
for her to lean into the camera and give up a quick nip shot before
her cans leave the frame. (25 seconds)
01:21:00 When the Nazi's leave town, the
collaborators become targets. As Malena is dragged into the street and
beaten, her clothes do some slipping off, showing boob and beav'. (23
Ultimo capodanno 1998
00:11:00 First, we see Monica's massive
breasts as she puts on a bra. Then she pulls off her panties and runs
around her apartment bottomless, showing off her super-fluffy muff and
awesome ass galore. (98 seconds)
00:19:00 More bombastic bottomlessness.
Monica storms around her home wearing just a bra. Hot, heaping hairpie.
Round, luscious rump. Go. Fall in love. (45 seconds)
genre 1997
00:13:00 It's a bird's-eye view of Monica's
way-more-than-ample boobs and generous glutes when she undresses for
bed. (21 seconds)
00:32:00 Right breast rising from beneath
the sheets to seduce Keanu. (28 seconds)
destino 1992
00:22:00 The camera pans up her famous
form to land on her naked nuggets . . . too bad it's so dark. (24
00:35:00 Mama mia! Monica ropes her guy
to the bed and straddles him, teasingly holding both bongos dangerously
close to his waiting face . . . (44 seconds)
Riffa 1991
00:27:00 Beautiful, bountiful Bellucci
allows some clown to pump away at her perfect form. Her famous flesh
bulbs are on full display . . . WOW! (53 seconds)
00:39:00 Mamnica tosses her coat aside
and stands before the mirror, her Buttlucci bared, with boobs reflected.
(28 seconds)
01:11:00 Ever wondered what the view is
like when Monica Bellucci is doing a pole dance on your Johnson rod?
Check out this clip if her doing just that, and drool. Awesome under-tit
shot! (28 seconds)
01:12:00 Just to balance out the previous
underboob shot, Monica allows her titanic titulars to be filmed from
overhead, as she lies in bed with her lover. (23
Monica Bellucci Links
Monica Bellucci nude pics & mpegs at
Hardcore Skin
Monica Bellucci naked pictures & movies
at Mr
Monica Bellucci topless photos & vidcaps
at CelebMovie.com
Monica Bellucci naked scenes at Celebrity Hardcore
Monica Bellucci filmography at IMDB
Monica Bellucci at TV.com
See FREE xxx images of this sexy actress at NudeCelebHound
these hot girls in your area...


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Guy With Face Tattoo Is Really Scared Of Puppies
I feel guilty laughing at this man's crippling phobia, but I was totally laughing at this man's crippling phobia. This is Marvin, and he runs away and starts weeping when confronted with a pit bull puppy. My Extreme Animal Phobia might be my new favorite show.
Gavon Laessig is a deputy news director and front page editor for BuzzFeed News and is based in New York.
Preview Your Response
Here Are The Top Stories
- A conservation group in Zimbabwe reported that Jericho, the brother of beloved lion Cecil, was shot and killed by a hunter. But some scientists monitoring the pride believe he is OK.
- Joe Biden has begun to "actively explore a possible presidential campaign," the New York Times reports.
- The trooper who pulled over Sandra Bland was disciplined for "unprofessional conduct" in the fall of 2014, records show.


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Nassau, Bahamas
My Rating
At the airport as scheduled, big car as requested, 2 stops as requested, same one the way back. Clean vehicles and friendly drivers. Well done, will definitely use your services again. Seamless!
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|Darrel Boyd Capshaw
|Sunday, 14 July 2013 04:04
Darrell Boyd Capshaw, 81, of Tompkinsville, KY passed away Friday, July 12th, at The Palace in Red Boiling Springs, TN.Darrell was born in Tompkinsville, Ky on March 15, 1932, a son of the late Virgie (Poland) and Winfred Capshaw.On June 12, 1954 in Glasgow, KY, by Newman Curtis, he was married to Margie (Rhoton) Capshaw who survives him. He worked in a Sawmill.
Darrell is survived by four daughters, Debbie Huff, of Gamaliel, KY; Judy Capshaw, of Tompkinsville, KY; Janie White, of Tompkinsville, KY; and Tammy Marquez, of Nevada.a son, Jerry Capshaw, of Gamaliel, KY; 10 grandchildren and 8 great grandchildren.
Darrell is preceded in death by a daughter; Sharon Cook; a son; Darrell Wayne Capshaw, 3 sisters; Allie "Doll" Shaw, Mary Young, and Ina Ford. and 3 brothers; Frank Capshaw, Charlie Capshaw and Harold Capshaw.
Funeral services will be held at Yokley Trible Funeral Home at 2:00 P.M. on Sunday, July 14th, with Gene Gearlds officiating. Visitation is Saturday, July 13 from 4:30-9 P.M. and Sunday 6:00A.M.-2:00 P.M. at Yokley Trible Funeral Home. Burial is in Macedonia Cemetery.


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This elegant Sligo Hotel is ideally located in Rosses Point, Sligo, on the shores of the Atlantic Ocean. With a Blue flag beach and a
challenging 18 hole golf links nearby, the Sligo Yeats Country Hotel Spa & Leisure Club provides its guests with a taste of leisure and relaxation amongst the breathtaking beauty of the North West of Ireland.
Our Rosses Point hotel proudly boasts an award winning Leisure Centre, and a world of relaxation in the Eros Luxury Spa.
Enter a world where calm replaces stress and tension. With 6
treatment rooms and relaxation suite, the Eros spa offers a wide range
of luxury therapies. Holistic, Spa, Aromatherapy, Beauty Treatments and Seaweed Baths are but a sample of whats on offer. To view all our Special Offer packages, click here.


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Maximum Strength Mick
SFGate.com's film critic Mick LaSalle tells you what he really thinks.
Monthly Archive for September, 2014
In "Abuse of Weakness" — a Very French Moment
In Catherine Breillat's ABUSE OF WEAKNESS, Isabelle Huppert plays a film director who, like Breillat, suffers a stroke. In the movie's very first minutes, she wakes up, realizes she is partially paralyzed and calls for an ambulance. "Half my bo… [Read More]
Cowie on "Umbrellas of Cherbourg"
Peter Cowie has a new article up, remembering "The Umbrellas of Cherbourg" and placing it in its historical context. Check it out. [Read More]
"Boxtrolls" Premiere in Venice
I forgot to post this picture when I was in Venice. These are the Boxtrolls at their premiere, doing a fairly forlorn meet and greet with their fans. The Boxtroll on the right is signing an autograph. The movie opens in San Francisco on Friday. [Read More]
Biennale College 2014
The other day, in Venice, I participated on a panel on the subject of the Biennale College, which is in its second year. The panel was moderated by Peter Cowie, who is the author of some thirty or so books and is the premiere Bergman scholar in the E… [Read More]
Frances McDormand at the Venice Film Festival
Frances McDormand was presented with the Persol Award at the Venice Film Festival yesterday, a prize in honor of "Visionary Talent." It was held at the Sala Grande, the theater used for the big premieres. She was accompanied by her husband, Joe… [Read More]
Show More


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RaptorLink is the Rutgers University-Camden Career Center's online job and internship database which connects candidates with your opportunities. This is a FREE service for our students, alumni and employer partners.
Through RaptorLink, organizations are able to easily post jobs and internships, manage candidate applications, and schedule On-Campus Interviews (OCI). You are also able to register for our Career Fairs.
New Employers / Recruiting Organizations use the following link: RaptorLink
- Click on "Register Under Register for a New Account " in the box on the right side of the screen.
- Once you complete your profile, you will receive another email welcoming you to the system with a username and password.
- For additional assistance, view the RaptorLink Employer User Guide RaptorLink Employer User Guide.pdf
If you have any difficulties or questions, please direct them to Terri Smith, our Employer Relations Coordinator at 856.225.6046 or email: email@example.com
Thank you for your participation and your leads.


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BETHANY, Okla. – A Bethany couple is now searching for a place to call home after an overnight fire destroyed their apartment.
It was in the middle of the night when Rachel Norman said she and her boyfriend awoke to find smoke and flames surrounding their home in the Council Crossings Apartments.
Norman said, "He saw something glowing from the spare bedroom. When he opened the door, he saw the flames. It was already engulfed."
The fire spread throughout the couple's apartment before reaching a vacant apartment nearby.
Firefighters were able to put out the flames but not before it destroyed their home.
Norman said, "This was our music room, our spare bedroom. There were all sorts of guitars and everything in here."
She added, "There's nothing salvageable."
Fire officials say they were able to pinpoint the cause of the fire to a faulty heater.
Battalion Chief Keith Cole, with the Bethany Fire Department, said, "We got a call about an electrical fire in the downstairs apartment. It appears the fire started in a heating closet area."
This isn't the first time Norman has had problems with the heater.
She says she complained to the management at Council Crossings multiple times about the faulty heater.
At one point, she says she went days without heat.
Norman said, "The last time that it broke, they came out and that's when they said the contractors would change it after the first of the year. A few days later still hadn't come and two weeks later, still hadn't come."
She says she doesn't have renter's insurance and hopes something like this never happens to anyone else.
Norman said, "You should put a little more importance and rush behind something, especially when it has something to do with electrical."
NewsChannel 4 stopped by the management office at Council Crossings on Tuesday.
There were a few workers inside but none of them wanted to talk about the incident.