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Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.
1. A process of preparing a stable suspension of sub-micron particles of a water-insoluble or substantially water-insoluble biologically active compound of up to 2000 nm in size comprising the successive steps of:
(a) dissolving a water-insoluble or substantially water-insoluble biologically active compound and a first surface modifier in a liquefied compressed gas solvent therefor and forming a solution of greater than 1% w/w of said compound in said solvent and thereafter;
(b) expanding the compressed fluid solution prepared in step (a) into water or aqueous solution containing a second surface modifier and water-soluble agents thereby producing a suspension of microparticles, and thereafter
(c) homogenizing the suspension of step (b) at high pressure.
2. The process according to claim 1, including the additional step of (d) recovering the microparticles so produced.
3. The process according to claim 1, wherein the first surface modifier and the second surface modifier are the same.
4. The process according to claim 1, wherein the first surface modifier and the second surface modifier are different.
5. The process according to claim 1, wherein one or both of the surface modifiers is a phospholipid.
6. The process according to claim 1, wherein one or both the surface modifiers is a surfactant.
7. The process of claim 1 wherein one or both of the surface modifiers is a mixture of two or more surfactants.
8. The process according to claim 1, wherein at least one surface modifier is a surfactant devoid or substantially completely devoid of phospholipid.
9. The process of claim 6 wherein the surface modifier is a polyoxyethylene sorbitan fatty acid ester, a block copolymer of ethylene oxide and propylene oxide, a tetrafunctional block copolymer derived from sequential addition of ethylene oxide and propylene oxide to ethylenediamine, an alkyl aryl polyether sulfonate, polyethylene glycol, hydroxy propylmethylcellulose, sodium dodecylsulfate, sodium deoxycholate, cetyltrimethylammonium bromide or combinations thereof.
10. The process of claim 5 wherein the surface modifier is of egg or plant phospholipid or semisynthetic or synthetic in partly or fully hydrogenated or in a desalted or salt phospholipid such as phosphatidylcholine, phospholipon 90 H or dimyristoyl phosphatidylglyerol sodium salt, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, lysophospholipids or combinations thereof.
11. The process of claim 1 wherein the compound is a cyclosporine, fenofibrate, or alphaxalone.
12. The process of claim 1 wherein the particles produced are less than 500 nm in size.
13. The process of claim 12 wherein the particles produced range from 5 up to about 200 nm in size.
14. The process of claim 1 wherein 99% of the particles produced are below 2000 nm.
15. The process of claim 1 wherein the liquefied compressed gas is carbon dioxide in the supercritical or sub-critical phase.
This application claims benefit to provisional 60/089,852 filed Jun. 19, 1998.
This invention provides processes for producing micrometer and sub-micrometer sized particulate preparations of biologically useful compounds that are water-insoluble or poorly water-soluble, particularly water-insoluble pharmaceutical agents.
A major problem in formulating biologically active compounds is their poor solubility or insolubility in water. For instance, over one third of the drugs listed in the United States Pharmacopoeia are either water-insoluble or poorly water-soluble. Oral formulations of water-insoluble drugs or compounds with biological uses frequently show poor and erratic bioavailability. In addition, drug insolubility is one of the most recalcitrant problems facing medicinal chemists and pharmaceutical scientists developing new drugs. Water-insolubility problems delay or completely block the development of many new drugs and other biologically useful compounds, or prevent the much-needed reformulation of certain currently marketed drugs. Although the water-insoluble compounds may be formulated by solubilization in organic solvents or aqueous-surfactant solutions, in many cases such solubilization may not be a preferred method of delivery of the water-insoluble agent for their intended biological use. For instance, many currently available injectable formulations of water-insoluble drugs carry important adverse warnings on their labels that originate from detergents and other agents used for their solubilization.
An alternative approach for the formulation of water-insoluble biologically active compounds is surface-stabilized particulate preparations. Small particle size formulation of drugs are often needed in order to maximize surface area, bioavailability and, dissolution requirements. Pace et al. ("Novel Injectable Formulations of Insoluble Drugs" in Pharmaceutical Technology, March 1999) have reviewed the usefulness of the microparticulate preparations of water-insoluble or poorly soluble injectable drugs.
In U.S. Pat. Nos. 5,091,187 and 5,091,188 to Haynes describe the use of phospholipids as surface stabilizers to produce aqueous suspension of submicron sized particles of the water-insoluble drugs. These suspensions are believed to be the first applications of the surface modified microparticulate aqueous suspension containing particles made up of a core of pure drug substances and stabilized with natural or synthetic bipolar lipids including phospholipids and cholesterol. Subsequently, similar delivery systems exploiting these principles have been described (G. G. Liversidge et al., U.S. Pat. No. 5,145,684; K. J. Illig et al. U.S. Pat. No. 5,340,564 and H. William Bosch et al., U.S. Pat. No. 5,510,118) emphasizing the usefulness of the drug delivery approach utilizing particulate aqueous suspensions.
In U.S. Pat. No. 5,246,707 Haynes teaches uses of phospholipid-coated microcrystals in the delivery of water-soluble biomolecules such as polypeptides and proteins. The proteins are rendered insoluble by complexation and the resulting material forms the solid core of the phospholipid-coated particle.
These patents and others utilized processes based on the particle size reduction by mechanical means such as attrition, cavitation, high-shear, impaction, etc achieved by media milling, high pressure homogenization, ultrasonication, and microfluidization of aqueous suspensions. However, these particle size reduction methods suffer from certain disadvantage, such as long process duration (high-pressure homogenization or microfluidization) and contamination (media milling, and ultrasonication). In addition, these methods may not be suitable for aqueous suspensions of compounds with limited stability in aqueous medium at the pH, high temperature and high pressure conditions prevailing in these processes.
Among the alternatives that address to these problems is a procedure which uses liquefied gasses for the production of microparticulate preparations. In one such method liquefied-gas solutions are sprayed to form aerosols from which fine solid particles precipitate. The phenomenon of solids precipitated from supercritical fluids was observed and documented as early as 1879 by Hannay, J. B. and Hogarth, J. "On the Solubility of Solids in Gases," Proc. Roy. Soc. London 1879 A29, 324,
The first comprehensive study of rapid expansion from a liquefied-gas solution in the supercritical region was reported by Krukonis (1984) who formed micro-particles of an array of organic, inorganic, and biological materials. Most particle sizes reported for organic materials, such as lovastatin, polyhydroxyacids, and mevinolin, were in the 5-100 micron range. Nanoparticles of beta-carotene (300 nm) were formed by expansion of ethane into a viscous gelatin solution in order to inhibit post expansion particle aggregation. Mohamed, R. S., et al. (1988), "Solids Formation After the Expansion of Supercritical Mixtures," in Supercritical Fluid Science and Technology, Johnston, K. P. and Penninger, J. M. L., eds., describes the solution of the solids naphthalene and lovastatin in supercritical carbon dioxide and sudden reduction of pressure to achieve fine particles of the solute. The sudden reduction in pressure reduces the solvent power of the supercritical fluid, causing precipitation of the solute as fine particles.
Tom, J. W. and Debenedetti, P. B. (1991), "Particle Formation with Supercritical Fluids—a Review," J. Aerosol. Sci. 22:555-584, discusses rapid expansion of supercritical solutions techniques and their applications to inorganic, organic, pharmaceutical and polymeric materials. This technique is useful to comminute shock-sensitive solids, to produce intimate mixtures of amorphous materials, to form polymeric microspheres and deposit thin films.
Most studies of rapid expansion from supercritical solution on organic materials utilize supercritical carbon dioxide. However, ethane was preferred to carbon dioxide for beta-carotene because of certain chemical interactions. Carbon dioxide is generally preferred, alone or in combination with a cosolvent. Minute additions of a cosolvent can significantly influence the solvent properties. When cosolvents are used in rapid expansion from a supercritical solution, care is required to prevent de-solution of the particles due to solvent condensing in the nozzle. Normally, this is achieved by heating the supercritical fluid, prior to expansion, to a point where no condensate (mist) is visible at the nozzle tip.
A similar problem occurs when carbon dioxide is used. During adiabatic expansion (cooling), carbon dioxide will be in two phases unless sufficient heat is provided at the nozzle to maintain a gaseous state. Most investigators recognize this phenomenon and increase the pre-expansion temperature to prevent condensation and freezing in the nozzle. A significant heat input is required (40-50 kcal/kg) to maintain carbon dioxide in the gaseous state. If this energy is supplied by increasing the pre-expansion temperature the density drops and consequently reduces the supercritical fluid's solvating power. This can lead to premature precipitation and clogging of the nozzle.
The solvent properties of liquefied-gas are strongly affected by their fluid density in the vicinity of the fluid's critical point. In rapid expansion from liquefied-gas solutions, a non-volatile solute is dissolved in a liquefied-gas that remains either in the supercritical or sub-critical phase. Nucleation and crystallization are triggered by reducing the solution density through rapid expansion of the liquefied-gas to atmospheric conditions. To achieve this the liquefied-gas is typically sprayed through 10-50 micron (internal diameter) nozzles with aspect ratios (L/D) of 5-100. High levels of supersaturation result in rapid nucleation rates and limited crystal growth. The combination of a rapidly propagating mechanical perturbation and high supersaturation is a distinguishing feature of rapid expansion from a liquefied-gas solution. These conditions lead to the formation of very small particles with a narrow particle size distribution.
There are a number of advantages in utilizing compressed carbon dioxide in the liquid and supercritical fluid states, as a solvent or anti-solvent for the formation of materials with submicron particle features. Diffusion coefficients of organic solvents in supercritical fluid carbon dioxide are typically 1-2 orders of magnitude higher than in conventional liquid solvents. Furthermore, carbon dioxide is a small linear molecule that diffuses more rapidly in liquids than do other antisolvents. In the antisolvent precipitation process, the accelerated mass transfer in both directions can facilitate very rapid phase separation and hence the production of materials with sub-micron features. It is easy to recycle the supercritical fluid solvent at the end of the process by simply reducing pressure. Since supercritical fluids do not have a surface tension, they can be removed without collapse of structure due to capillary forces. Solvent removal from the product is unusually rapid. No carbon dioxide residue is left in the product, and carbon dioxide has a number of other desirable characteristics, for example it is non-toxic, nonflammable, and inexpensive. Furthermore, solvent waste is greatly reduced since a typical ratio of antisolvent to solvent is 30:1.
Exploiting these concepts Henriksen et al. in WO 97/14407, disclosed a process using compressed fluids to produce sub-micron sized particles of water insoluble compounds with biological uses, particularly water insoluble drugs by precipitating a compound by rapid expansion from a supercritical solution in which the compound is dissolved, or precipitating a compound by spraying a solution, in which the compound is soluble, into compressed gas, liquid or supercritical fluid which is miscible with the solution but is antisolvent for the compound. In this manner precipitation with a compressed fluid antisolvent (compressed fluid antisolvent) is achieved.
An essential element of this process is the use of phospholipids and other surface modifiers to alter the surface of the drug particles to prevent particle aggregation and thereby improve both their storage stability and pharmacokinetic properties. This process combines or integrates phospholipids or other suitable surface modifiers such as surfactants, as the aqueous solution or dispersion in which the supercritical solution is sprayed. The surfactant is chosen to be active at the compound-water interface, but is not chosen to be active at the carbon dioxide-organic solvent or carbon dioxide-compound interface when carbon dioxide is used as the supercritical solution. The use of surface modifying agents in the aqueous medium allowed making submicron particles by the compressed fluid antisolvent process without particle aggregation or flocculation.
FIG. 1 is a graph showing the size distribution (relative volume v. particle size in nm) of cyclosporine produced in Example 3, and
FIG. 2 is a graph showing the size distribution (relative volume v. particle size in nm) of cyclosporine produced in Example 4, and
However, this prior process suffered from a very long duration of spray of the supercritical solution to obtain a substantial quantity of the desired product. The long duration of spray-process may be attributed to a slow rate of association of the surface modifier molecules or their assemblies in the aqueous medium with the newly precipitated solute particles.
During experimentation with the process of WO 97/14407 described above it was surprisingly found that incorporation of a surface modifier in both the supercritical (or sub-critical) liquefied gas along with incorporation of a surface modifier in the water insoluble substance allowed one to achieve a very rapid production of surface stabilized nanometer- to micrometer-sized particulate suspensions. The principle feature of the present invention is believed to be rapid attainment of intimate contact of the dissolved drug and the surface modifier during the very fast precipitation step of the drug from their solution in the liquefied gas.
While very rapid precipitation is a characteristic of precipitation of solutes from liquefied gases, the rapid intimate contact with the surface modifier is achieved by having the surface modifiers dissolved in the liquefied-gas containing the dissolved drug. A rapid intimate contact between the surface modifier and the newly formed particle substantially inhibits the crystal growth of the newly formed particle. In addition, if the surface modifier(s) is not included with the dissolved drug the rate at which the liquefied-gas droplet containing the drug is brought into contact with the anti-solvent is much slower if very small stable particles are to be obtained. Thus a key feature of the invention is the high productivity of the process.
Although at least one (first) surface modifier should be dissolved along with the water insoluble substance to be reduced in size in the liquefied gas in the inventive process, additional (second) surface modifying agents of the same or different chemical nature may also be included in the aqueous medium. Further, during or after precipitation the fluid streams may be subjected to additional high shear forces, cavitation or turbulence by a high-pressure homogenizer to facilitate intimate contact of the particle surface and the surface modifier. Thus, in those cases where all the surface modifier is dispersed in the aqueous medium and the liquefied gas contains only the water insoluble substance, additional high shear forces, cavitation or turbulence by a high-pressure homogenizer can be exploited to facilitate the intimate contact of the particle surface and the surface modifier.
Thus, the overall objective of the present invention is to develop a process with high productivity based on the use of liquefied gas solvents, including supercritical fluid technology, that yields surface modifier stabilized suspensions of water insoluble drugs with an average particle size of 50 nm to about 2000 nm and a narrow size distribution. The process is robust, scalable and applicable to a wide range of water-insoluble compounds with biological uses.
The present invention includes procedures for using super critical or compressed fluids to form surface modified particles of up to about 2000 nm in size and usually below 1000 nm, desirably less than 500 nm, preferably less than about 200 nm and often in a range of 5 to 100 nm in size. The size of the particles refers to volume weighted mean diameters of these particles suspended in aqueous medium.
The process of the present invention includes forming aqueous microparticulate suspensions of water insoluble or poorly water soluble compounds while simultaneously stabilizing of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied-gas (Rapid Expansion of Liquefied Gas Solution, RELGS).
Alternatively another embodiment of the invention includes forming aqueous microparticulate suspensions of water insoluble or poorly water soluble compounds while simultaneously stabilizing the same with surface modifier molecules by rapid expansion into an aqueous medium of a compressed solution of the compound and surface modifiers in a liquefied-gas and homogenizing the aqueous suspension thus formed with a high pressure homogenizer (Rapid Expansion of Liquefied-Gas Solution and Homogenization, RELGS-H).
While not wishing to be bound by any particular theory, the processes of this invention are believed to induce rapid nucleation of the liquefied-gas dissolved drugs and other biologically active substances in the presence of surface modifying agents resulting in particle formation with a desirable size distribution in a very short time. Phospholipids or other suitable surface modifiers such as surfactants, as may be required, may be integrated into the processes as a solution or dispersion in the liquefied gas. In addition, the surface modifier may or may not be incorporated via its solution or dispersion in the aqueous medium. Alternatively, some of the surface modifiers may be dissolved in the liquefied gas along with the water insoluble substance and expanded into a homogenized aqueous dispersion of rest of the surface modifier of the formulation. The introduction of suitable surface modifying agents in the above noted processes serves to stabilize the generated small particles and suppress any tendency of particle agglomeration or particle growth while they are formed.
By industrially useful insoluble or poorly soluble compounds we include biologically useful compounds, imaging agents, pharmaceutically useful compounds and in particular drugs for human and veterinary medicine. Usually, the water insoluble compounds are those having a poor solubility in water, that is less than 5 mg/mL at a physiological pH of 6.5 to 7.4, although the water solubility may be less than 1 mg/mL and even less than 0.1 mg/mL.
Examples of some preferred water-insoluble drugs include immunosuppressive and immunoactive agents, antiviral and antifungal agents, antineoplastic agents, analgesic and anti-inflammatory agents, antibiotics, anti-epileptics, anesthetics, hypnotics, sedatives, antipsychotic agents, neuroleptic agents, antidepressants, anxiolytics, anticonvulsant agents, antagonists, neuron blocking agents, anticholinergic and cholinomimetic agents, antimuscarinic and muscarinic agents, antiadrenergic and antiarrhythmics, antihypertensive agents, antineoplastic agents, hormones, and nutrients. A detailed description of these and other suitable drugs may be found in Remington's Pharmaceutical Sciences, 18th edition, 1990, Mack Publishing Co. Philadelphia, Pa.
A range of compressed gases in the supercritical or sub-critical fluid phases have been reported in the prior art (for example, U.S. Pat. No. 5,776,486, and Tom, J. W. and Debenedetti, P. B. (1991), "Particle Formation with Supercritical Fluids—a Review," J. Aerosol. Sci. 22:555-584) from which a suitable gas may be selected for the purpose of the present invention. These include but are not limited to gaseous oxides such as carbon dioxide and nitrous oxide; alkanes such as ethane, propane, butane, and pentane; alkenes such as ethylene and propylene; alcohols such as ethanol and isopropanol; ketones such as acetone; ethers such as dimethyl or diethyl ether; esters such as ethyl acetate; halogenated compounds including sulfur hexafluoride, chlorofluorocarbons such as trichlorofluoromethane (CCl3F, also known as Freon 11), dichlorofluoromethane (CHCl2F, also known as Freon 21), difluorochloromethane (CHClF2, also known as Freon 22), and fluorocarbons such as trifluoromethane (CHF3, also known as Freon 23); and elemental liquefied gases such as xenon and nitrogen and other liquefied compressed gases known to the art.
Liquefied carbon dioxide was used to prepare rapid expansion solutions of the drugs described in the following examples. Carbon dioxide has a critical temperature of 31.3 degrees C. and a critical pressure of 72.9 atmospheres (1072 psi), low chemical reactivity, physiological safety, and relatively low cost. Another preferred supercritical fluid is propane.
Examples of some suitable surface modifiers include: (a) natural surfactants, such as casein, gelatin, natural phospholipids, tragacanth, waxes, enteric resins, paraffin, acacia, gelatin, and cholesterol, (b) nonionic surfactants such as polyoxyethylene fatty alcohol ethers, sorbitan fatty acid esters, polyoxyethylene fatty acid esters, sorbitan esters, glycerol monostearate, polyethylene glycols, cetyl alcohol, cetostearyl alcohol, stearyl alcohol, poloxamers, polaxamines, methylcellulose, hydroxycellulose, hydroxy propylcellulose, hydroxy propylmethylcellulose, noncrystalline cellulose, and synthetic phospholipids, (c) anionic surfactants such as potassium laurate, triethanolamine stearate, sodium lauryl sulfate, alkyl polyoxyethylene sulfates, sodium alginate, dioctyl sodium sulfosuccinate, negatively charged phospholipids (phosphatidyl glycerol, phosphatidyl inosite, phosphatidylserine, phosphatidic acid and their salts), and negatively charged glyceryl esters, sodium carboxymethylcellulose, and calcium carboxymethylcellulose, (d) cationic surfactants such as quaternary ammonium compounds, benzalkonium chloride, cetyltrimethylammonium bromide, and lauryldimethylbenzyl-ammonium chloride, (e) colloidal clays such as bentonite and veegum, (f) natural or synthetic phospholipid, for example phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, phosphatidic acid, lysophospholipids, egg or soybean phospholipid or a combination thereof. The phospholipid may be salted or desalted, hydrogenated or partially hydrogenated or natural semisynthetic or synthetic. A detailed description of these surfactants may be found in Remington's Pharmaceutical Sciences, 18th Edition, 1990, Mack Publishing Co., PA; and Theory and Practice of Industrial Pharmacy, Lachman et al., 1986.
The following examples further explain and illustrate the invention:
Phase Behavior of Water Insoluble Compound in Compressed Liquefied Gasses.
In order to assess whether a particular water insoluble compound should be formulated as an aqueous submicron particulate suspension from its solution in the liquefied gasses, the solubility of the candidate drugs in the liquefied gasses was measured.
To prepare solutions with a constant molar composition, measured amounts of drug (fenofibrate) were charged to a constant volume view cell. Temperature was kept constant at 60° C. Pressure was varied from 1300 to 4000 psi by pumping the compressed liquefied gas into the view cell. The phase behavior was determined visually by noting the pressure at which the solid drug appeared to dissolve. A summary of fenofibrate solubility in liquefied carbon dioxide, propane and ethane is given in Table I. The solubility values of >1% w/w in any solvent would allow the fine-particulate preparation from these solvents.
Fenofibrate Microparticle Formation by the RELGS Process
A solution containing Fenofibrate (2 g), Lipoid E-80 (0.2 g), Tween-80 (0.2 g) in the liquefied carbon dioxide pressurized to 3000 psi was expanded through a 50 mm orifice plate into water held at atmospheric pressure and room temperature (22° C.). A fine suspension of fenofibrate was obtained with a mean particle size of about 200 nm. The particle sizing was performed by photon correlation spectroscopy using Submicron Particle Sizer-Autodilute Model 370 (NICOMP Particle Sizing Systems, Santa Barbara, Calif.). This instrument provides number weighted, intensity weighted, and volume weighted particle size distributions as well as multi-modality of the particle size distribution, if present.
A fine spray-nozzle was constructed with PEEK capillary tubing of an internal diameter of 63.5 mm. This PEEK nozzle was fastened with a M-100 Minitight male nut and attached to an Upchurch SS20V union body which was further attached to a Ľ inch high pressure manifold via Swagelok™ brand fittings of appropriate size. Except for the PEEK tubing all other components were made up of 316 stainless steel. A liquefied gas solution of the water insoluble substance was introduced at high pressure (>1000 psig) through the Ľ inch high pressure manifold into the 63.5 mm PEEK nozzle to be expanded into the aqueous medium. The vessel for the liquefied gas solution was charged with 1 g of cyclosporine and 0.2 g of Tween-80. The vessel was filled with carbon dioxide at 5000 psig and heated to about 24° C. The vessel was allowed to stand for about 20 minutes for complete dissolution and for attaining equilibrium. Separately, a 2% w/w suspension of egg phospholipid (Lipoid E80 from Lipoid GmbH) in a 5.5% solution of mannitol was homogenized at 6000 psi with an Avestin Emulsiflex C50 homogenizer (Avestin Inc, Ottawa, Canada) for 15 min when it produced a clear dispersion. The pH of the phospholipid suspension was adjusted to 8.0 with aqueous NaOH solution prior to homogenization. The carbon dioxide solution of cyclosporine and Tween-80 that was held at 24° C. and 5000 psig was expanded into the aqueous dispersion of egg phospholipid. Very rapidly, in about 3 minutes, a translucent aqueous suspension of about 23 nanometer particle size was obtained (See FIG. 1). This example provides a simple scalable process by the way of incorporation of several such PEEK nozzles within a manifold and simultaneously expanding into a reservoir containing appropriate amount of the aqueous medium. The PEEK nozzle is known to be inert and very inexpensive. Construction of the nozzle is very simple and can be done in less than 10 minutes.
Cyclosporine Microparticle Formation by the RELGS-H Process
An aqueous suspension containing Mannitol (5.5%), Lipoid E-80 (2%), and Tween 80 (2%), was prepared. A solution of cyclosporine in the Liquifed gas was also prepared and kept at 2000 psig and 60° C. This solution was expanded through a 63.5 mm PEEK nozzle into the aqueous suspension. A suspension of about 3 g cyclosporine was made in this way. The resulting suspension was homogenized for 8 passes at 6,000 psig. The final mean particle size after homogenization was 86 nanometers with the 99 percentile at 150 nm (see FIG. 2) as measured using the Submicron Particle Sizer-Autodilute Model 370 (NICOMP Particle Sizing Systems, Santa Barbara, Calif.).
While the invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not to be limited to the disclosed embodiment, but on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims.
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Virginia's Lt. Governor Bill Bolling took the Ford Focus all-electric pace car out for a drive before its big debut at the Capital City 400 this weekend. At Richmond International Raceway, the Focus EV is set to become the first fully electric pace car in NASCAR.
Two Ford electric pace cars were unveiled today at the Virginia State Capitol to kick of this weekend's race, with company including NASCAR's managing director of Green Innovation, Mike Lynch. "The arrival of the 2012 Ford Focus Electric pace car is a strong example of how the innovation cycle around green transportation is accelerating," Lynch said during the pace cars' reveal.
Ford has certainly helped accelerate that process, not only with the Ford Focus EV pace car, but first with the Ford Fusion Hybrid pace car. The Fusion hybrid marked the first time a hybrid served as a NASCAR pace car at the Ford 400 in 2008 at Homestead-Miami Speedway.
The Ford Focus EV can recharge in about half the time as the Leaf (3 to 4 hours for the Ford), and has EPA-rated figures of 110/99 city/highway gas-equivalent mpg (mpge) over the Leaf's 106/92. As soon as Ford determines how to make the Focus EV sound as pleasing as a Mustang GT, the automaker might really capture our attention.
Source: Ford

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The Microbiology Graduate PhD Program is an MIT-wide program that is designed to provide students with broad exposure to modern areas of microbiology and depth in the chosen area of thesis work. There are more than 50 faculty in 10 different departments and divisions that study microbes. Graduate students admitted to the program will join a vibrant, thriving microbiology community on the MIT campus and will receive training in a broad range of areas in microbiology.
The major components of the training program are described in detail below along with information on life as a graduate student at MIT.
Students with a particularly strong background in any of the below areas may have the option of placing out of the related course; approval of the Graduate Education Committee is required.
Research Rotations in Microbiology - 7.499 (Fall, IAP, Spring) (12 units) Staff
Introduction to faculty participating in the Interdepartmental Microbiology graduate program and
a series of lab rotations. During the first year, students will rotate through three labs of MIT faculty
that participate in the Microbiology Graduate Program. These rotations will help provide students
a broad exposure to microbiology research and will be used to select a lab for their thesis
research by the end of the first year. Given the interdisciplinary nature of the program
and many research programs, students may be able to work jointly with more than one research
supervisor. Required and limited to graduate students in the microbiology program.
Students must take three elective courses, totaling 36 units, from the following list. Electives can be chosen to provide depth in a specific area of interest or additional breadth in training. Courses from some other areas may also fulfill the requirement, with the approval of the Graduate Education committee.
Environmental Microbiology – 1.89 (Fall) (12 units)
Principles of Bioinorganic Chemistry – 5.062 (Fall) (6 units) (Part I)
Enzymes: Structure and Function – 5.50 (Fall) (12 units)
Advanced Biological Chemistry – 5.52 (Fall) (12 units)
Microbial Physiology – 7.62 (Fall) (12 units)
Topics in Metabolic Biochemistry – 7.75J/5.77J (Fall) (12 units) Staff
Systems Biology – 8.591J/7.81J (Fall) (12 units)
Metabolic and Cell Engineering – 10.544 (Fall) (9 units)
Statistical Thermodynamics – 10.546J/5.70J (Fall) (12 units)
Systems Microbiology – 20.106J (Fall) (12 units)
Biomolecular Kinetics and Cellular Dynamics –20.420J(Fall) (12 units)
Analysis of Biological Networks – 20.440 (Fall) (12 units)
Quantitative Genomics – HST508 (Fall) (12 units)
Biophysical Chemistry – 5.64 (Spring) (6 units; second half of semester) Staff
Biophysical Chemistry Techniques – 5.78 (6 units first half) or 7.71 (12 units whole semester) (Spring) (6 or 12 units)
Foundations of Algorithms and Computational Techniques in Systems Biology – 6.581J/20.482J (Spring) (12 units)
Computational Systems Biology –6.874J (Spring) (12 units)
Molecular Biology – 7.58 (Spring) (12 units)
Immunology – 7.63 (Spring) (12 units)
Molecular Basis of Infectious Disease Graduate - 7.66 (Spring) (12 units)
Regulation of Gene Expression – 7.70 (Spring) (12 units)
Nucleic Acids, Structure, Function, Evolution and Their Interactions with Proteins – 7.77 (Spring) (12 units)
Foundations of Computational and Systems Biology – 7.91J/20.490J (Spring) (12 units)
Biochemical Engineering – 10.542 (Spring) (12 units)
Molecular and Cellular Pathophysiology – 20.450 (Fall) (12 units)
During the first year, students will rotate through three labs of MIT faculty that participate in the Microbiology Graduate Program. These rotations will help provide students broad exposure to microbiology research and will be used to select a lab for their thesis research by the end of the first year. Given the interdisciplinary nature of the program and many research programs, students may be able to work jointly with more than one research supervisor.
Learning to effectively communicate scientific ideas is an important skill. Students in the Microbiology program will have an opportunity to improve their communication skills through teaching. Each student will serve as a teaching assistant for one semester in an undergraduate or graduate subject related to microbiology. This will typically take place in the second year.
All students will participate in a course on the ethical conduct of research. This will typically take place during the first year.
Students will proceed to Ph.D. candidacy after successful completion of a qualifying exam, typically during the second year. Students will submit a written research proposal in the style of a grant or fellowship application based on their planned thesis project. Students will then present and discuss the research proposal with a small committee of faculty.
In the first year, students will be advised by members of the graduate committee. Once students join a thesis lab, the research mentor will be the primary advisor. Early in the second year, students will form a thesis committee and meet at least annually. The committee will consist of faculty with expertise in the student's area of research and collectively provide the breadth expected by the program. The thesis committee will primarily provide advice on research. In addition, in the student's early years the thesis committee will also provide advice on course-work to ensure that students have the appropriate breadth and depth for his or her educational program. In later years, the graduate and thesis committees will also provide students with advice on career options.
All students in the program will receive a stipend that is sufficient to support living in the Cambridge/Boston area. The stipend will be approximately the same as for graduate students in other MIT departments, which is ~$35,000 in 2015-2016.
Students in the program will be financially supported throughout their training. This support includes tuition, stipend, and health insurance.
During the first year, students are supported by funds from the School of Science, the School of Engineering, the Provost's Office, and the Departments of Biological Engineering, Biology, Chemical Engineering, and Chemistry. In subsequent years, students will be supported as Research Assistants in their thesis lab.
Although students will be supported, they are strongly encouraged to apply for fellowships. Students applying to the Microbiology program are eligible for many of these fellowships, including those detailed on the following websites:
National Science Foundation (NSF)
Environmental Protection Agency (EPA)
National Defense Science & Engineering Graduate Fellowship (NDSEG)
Under-represented minorities should also see these websites:
Howard Hughes Medical Institute (HHMI)
Additionally, student can visit the Graduate Students Office website which has a comprehensive listing.
Living in the Boston/Cambridge area offers students a wide range of activities and opportunities outside the lab. MIT has a number of community and student groups, sponsors an extensive intramural sports program, and provides access to excellent athletic facilities. Boston and Cambridge are also rich in cultural activities, the arts, museums, theater, sports, and more. Cape Cod, New Hampshire, and Vermont are all just a couple of hours and less away, offering fantastic skiing, hiking, beach, and other outdoor activities. For more information about life at MIT, visit some of these websites:
Graduate students have the option of living on-campus or off-campus. Upon admission to the program, students will receive housing information. In addition, see the Housing at MIT website.
Boston and Cambridge offer excellent public transportation options for getting around, commuting, and accessing Boston's Logan International Airport. The MBTA runs an extensive subway and bus system and MIT offers subsidized T-passes. For more information, see the MIT Parking and Transportation website.
See this separate section for complete information on applying to the MIT Microbiology Graduate Program.


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Vietnam high-quality goods fair opened
HCM City Trade Promotion Centre joined with Sai Gon Tiep Thi newspaper and People's Committee of Can Tho Mekong province officially opened Vietnam high-quality goods fair 2004 at Can Tho International Exhibition and Fair Centre on October 8. The fair is scheduled from October 8–13 2004 with participation of 200 businesses with 650 stands.
On the same day of October 8, Can Tho People's Committee organised a seminar of introducing investment potential and opportunity and economic development cooperation of Can Tho. At the seminar, officer of the committee said that in the period of 2004–2005, Can Tho has attracted 17 investment projects in infrastructure, processing industry, engineering, chemical and tourism with total capital of about US$300 million. Currently, the city has two industrial zones, three centres of handicraft industry with preferential policies of tax, land rent.
Category: Business


text:
A 2012 video game, developed by Nintendo for the Wii U. Nintendo Land consists primarily of a collection of smaller games based on major Nintendo franchises. It was a pack-in game designed to demonstrate the capabilities of the Wii U gamepad.
Nintendo Land is designed as a theme-park with "attractions". Each attraction represents a major Nintendo franchise and contains one or more games. In addition to the attractions, there is also a plinko-like coin game.
- The Legend of Zelda: Battle Quest
- Metroid Blast
- Pikmin Adventure
- Mario Chase
- Luigi's Ghost Mansion
- Animal Crossing: Sweet Day
- Takamaru's Ninja Castle
- Donkey Kong's Crash Course
- Captain Falcon's Twister Race
- Balloon Trip Breeze
- Yoshi's Fruit Cart
- Octopus Dance
General Information
- Release Date: November 18, 2012 (NA), November 30, 2012 (PAL), December 8, 2012 (Japan)
- Developer/Publisher: Nintendo
- Available on: wii-u exclusively


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Lloyd Napier, 85, died Wednesday, March 6 at his residence in Stanton.
He was a retired coal miner and son of the late Drew Napier and the late Polly Campbell Napier Engle. He was also preceded in death by sons Lloyd Napier, Jr. and Donald Napier; daughter Barbara Napier Madden; two sisters; two brothers; granddaughters Pamela and Michelle Warfield; and great-grandson Tyler Keith Warfield.
He is survived by his wife, Geneva Napier; daughters Clara Napier and husband Granville, Fay Warfield and husband Keith, and Molly Grigsby and Charles Caudill; sons Orville and Lyndon Napier; daughter-in-law Tina Napier; brother Pearl Napier; 12 grandchildren; 17 great-grandchildren; four great-great-grandchildren; and a host of family and friends.
Arrangements are being handled by Maggard Brothers Funeral Home of Hazard, where the family will receive friends from 6 to 9 p.m. on Friday, March 8. Services will begin at 11 a.m. on Saturday, March 9 with Rev. Bartholomew Perry officiating. Interment will be at Engle Cemetery on Trace Branch.


text:
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Waterlife Aquarium
Street address: Shp 8-23/27 Pakington St
Postcode: 3218
Town or Suburb: Geelong West
State: VIC
GPS coordinates: -38.133596,144.34964000000002
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Mickey mouse birthday cake pictures
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text: When Anna Eshoo was in middle school she wanted to be an eye doctor. She didn't know why, but she liked going to the doctor and all the things they did. But a teacher told her to forget her dream. "Girls aren't good at math," she told her. Eshoo, who has served in Congress for more than 20 years, was at Campbell Middle School Thursday to encourage girls -- and boys-- not to be held back from their dreams.


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Kirsten Boehlke Farnsworth Spelling Bee Champion
Seventh grader, Kirsten Boehlke won Farnsworth Middle School Spelling Bee Champion on Wednesday January 16th. Daniel Rehm was the runner up. Kirsten competed in the Regional Spelling Bee held at Urban on Monday, January 28th at 3:30 in the auditorium.
Students at Farnsworth competed in the first round of the spelling bee. Round two was grade level competitions between students who advanced from the preliminary spelling bee. Grade level winners moved on to compete in the school wide bee. Sixth graders competing in the school wide bee were: Drew Kittelson and Eli Koehler. Seventh graders participating were: Ryan Dicke, Daniel and Kirsten. Eighth graders participating were Charity Grijalva, Matt Stapel, Zac Bresser and Anna Macknick.
Principal Todd DeBruin congratulates Farnsworth Spelling Bee Champion Kirsten Boehlke
Sheboygan Area School District Press Release
February 12, 2013


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Why should I get a Mac for my video editing?
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SlyTX, according to Wikipedia, "According to a 2007 SCRI study, Final Cut made up 49% of the US professional editing market, with Avid at 22%.[1] A published Survey in 2008 by the American Cinema Editors Guild placed their users at 21% FCP (and growing from previous surveys of this group), while all others are still on an Avid system of some kind."
So it appears that FCP will only continue to gain ground. I think those who complain about the updates to FCS are those who feel that things should constantly be added to just for the sake of updating, but honestly, I think FCP is rather mature and fully-formed and only needs a few things tweaked to stay competitive. Obviously there are features in other editing programs that are better than their FCP equivalents, but in general I'd say that FCP does more than what I need it to do. However, I too am an intermediate level editor. Perhaps more professional level editors have more needs than I do, but the only thing I've really heard that FCP is lacking in is media management. I'm sure as FCP is improved, such differences will become negligible. I have only dabbled a little with Premiere Pro and it actually seems pretty similar to FCP, which seems to be what most people think.
In general, while it's always interesting to see what new features might come to FCP, I have not been disappointed with it at all. But then I'm not one of these people who thinks that every program, computer or device needs to be updated every single year.
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text:
Courses: Algebra I (MATHH333A01)
Fall 2013
A rigorous treatment of fundamental algebraic structures. Topics include: axioms for integers, modular arithmetic, polynomials, rings, fields, and introduction to groups. Students must choose one discussion hour (TBA).
Prerequisites: Math 215 and either Math 121 or 216, or instructor consent. Corequisite of Math 299 for students who have not had Math 216 or math at the 300 level.
Fulfills: NA II
Mathematics and Statistics (Web site)
Taught By
Haverford, Kosh E309
Meeting Times


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|« Back to Article
Three Texas venues named best for live music
By Rebecca Salinas : August 21, 2014 : Updated: August 21, 2014 4:33pm
Photo By Kevin Mazur/WireImageBillboard Magazine named three Texas venues in its list of "25 Most Popular Music Clubs in the U.S.," which includes a lesser-known Austin hotspot. Click through to see Billboard's Top 25 around the country.
Photo By Kevin Mazur/WireImage25. Stubb's Bar-B-Q
Austin, Texas
Attendance: 116,582
Photo By Joey Foley/FilmMagic24. Stage AE
Pittsburgh, Pennsylvania
Attendance: 124,013
Photo By Al Pereira/WireImage23. The Paramount
Huntington, New York
Attendance: 127,730
Photo By Joey Foley/FilmMagic22. Lifestyle Communities Pavilion
Columbus, Ohio
Attendance: 128,975
Photo By Scott Legato/Getty Images21. The Fillmore
Detroit, Michigan
Attendance: 129,199
Photo By The Washington Post/The Washington Post via Getty Images20. House of Blues
Myrtle Beach, South Carolina
Attendance: 129,528
Photo By Denise Truscello/Getty Images for Scleroderma Research Foundation19. House of Blues
Las Vegas, Nevada
Attendance: 131,208
Photo By Chip Auger/Getty Images18. The Fillmore
Charlotte, North Carolina
Attendance: 133,212
Photo By Taylor Hill/Getty Images17. Irving Plaza
New York, New York
Attendance: 135,398
Photo By C Flanigan/WireImage16. The Fillmore
San Francisco, California
Attendance: 140,100
Photo By Erika Goldring/FilmMagic15. House of Blues
New Orleans, Louisiana
Attendance: 145,077
Photo By Jeff Kravitz/FilmMagic14. Palladium
Hollywood, California
Attendance: 148,555
Photo By Seth McConnell/The Denver Post via Getty Images13. The Fillmore
Denver, Colorado
Attendance: 151,387
Photo By Bill O'Leary/The Washington Post via Getty Images12. The Fillmore
Silver Spring, Maryland
Attendance: 152,332
Photo By Patrick R. Murphy/Getty Images11. House of Blues
Cleveland, Ohio
Attendance: 155,566
Photo By Jerod Harris/WireImage10. House of Blues
San Diego, California
Attendance: 155,938
Photo By Axelle/Bauer-Griffin/Bauer-Griffin/GC Images9. House of Blues
Los Angeles, California
Attendance: 172,005
Photo By Rick Diamond/WireImage8. Tabernacle
Atlanta, Georgia
Attendance: 185,769
Photo By Christopher Polk/Getty Images for EFG7. House of Blues
Anaheim, California
Attendance: 192,424
Photo By Bob Levey/Getty Images for SiriusXM6. House of Blues
Houston, Texas
Attendance: 209,799
Photo By Daniel Boczarski/Redferns via Getty Images5. House of Blues
Chicago, Illinois
Attendance: 211,446
Photo By Glenn James/WireImage4. House of Blues
Dallas, Texas
Attendance: 222,988
Photo By Kyle Gustafson/The Washington Post via Getty Images3. 9:30 Club
Washington, D.C.
Attendance: 268,727
Photo By Paul Marotta/Getty Images2. House of Blues
Boston, Massachusetts
Attendance: 322,755
Photo By Kellie Warren/Getty Images1. House of Blues
Orlando, Florida
Attendance: 339,470
Billboard Magazine named three Texas venues in its list of "25 Most Popular Music Clubs in the U.S." Click through the gallery to see other popular music clubs in Texas.
Photo By Kevin Mazur/WireImageStubb's Bar-B-Q, 801 Red River St., in Austin was named one of the most popular live music venues in the country.
Photo By For the Houston ChronicleHouse of Blues-Houston, 1204 Caroline Street in Houston.
Photo By Matt Slocum/APHouse of Blues-Dallas, 2200 N. Lamar Street in Dallas
Photo By Mike Damante/For the ChronicleEmo's, 2015 E. Riverside in Austin.
Photo By Libby Castillo, For mySA.comBackstage Live, 1305 E. Houston Street in San Antonio.
Photo By Xelina Flores-ChasnoffThe Korova, 107 E. Martin Street in San Antonio.
Photo By Jamaal Ellis/For the ChronicleWarehouse Live, 813 Saint Emanuel Street in Houston.
Photo By Andrew InnerarityThe Continental Club, which has locations in Austin, 1315 S. Congress Ave., and Houston, 300 Main St.
Photo By Evans CaglageKessler Theater, 1230 W. Davis Street in Dallas.
Billboard Magazine names three Texas venues in its list of "25 Most Popular Music Clubs in the U.S.," which includes a lesser-known Austin hotspot.
Click through the slideshow to see local music legend Jim Beal Jr.'s favorite venues in the state.
Jim Beal Jr., wrote the Night Lights column when he covered the area music scene for the San Antonio Express-News before his retirement. He also plays bass in the local band Miss Neesie & the Ear Food Orchestra. Beal is the host of the "Third Coast Music Network" show from 3-7 p.m. Thursdays on KSYM, 90.1 FM. These are his favorite places to enjoy live music.
Photo By mysaGruene Hall, 1281 Gruene Rd., New Braunfels: The 100-plus-year-old hall is roots music central. Bookings include local, area, regional and touring acts; country, blues, troubadours, rock 'n' roll, Texas Music and more. A Sunday afternoon at Gruene Hall, with music starting about noon and about 5 p.m., and no cover charge, is one of the best, and most fun, entertainment deals going.
Photo By XELINA FLORES-CHASNOFFTuckers Kozy Korner, 1338 E Houston St.: Long-running, real-deal cocktail lounge on the near East Side has live jazz Mondays and Tuesdays. The Jim Cullum Jazz Band plays traditional jazz Monday nights at 7 p.m.
Photo By ALICIA WAGNER CALZADA/SPECIAL TO THE EXPRESS-NEWSSam's Burger Joint, 330 E Grayson St.: The music hall at Sam's is a good-sized room with an excellent sound system. Bookings are eclectic and include blues, rock 'n' roll, revved-up country and more from local, regional and touring acts. And the burgers are also very good.
Photo By ANDREA M. ALLINGER/210SABoardwalk Bistro, 4011 Broadway St.: More restaurant than live music room, the Bistro nonetheless has excellent jazz on Fridays and Saturdays.
John T. Floore Country Store, 14492 Old Bandera Rd., Helotes: Another old dance hall, Floore's was made famous outside Texas by Willie Nelson's song "Shotgun Willie." Nelson played at Floore's once a week back in the day, and still works in a show there now and then. Floore's has Texas Music, and more, Fridays and Saturdays and keeps the Sunday free family dance tradition going.
Barriba Cantina, 111 W Crockett St. #214: Most River Walk night spots feature music that can be heard in any tourist spot in the nation. Barriba features local blues, roots rock and singing songwriters, and lots of each, making it an excellent draw for tourists and locals.
502 Bar, 502 Embassy Oaks: With plenty of elbow room, a great stage and sound/lights to match, the 502 offers up plenty of indie-rock.
Photo By XELINA FLORES-CHASNOFFLuna, 6740 San Pedro Ave.: With its old-school night club vibe and bookings that include funk, soul, Afro-beat, swing and more, Luna has a touch of elegance without pretense.
Photo By MARVIN PFEIFFER/PRIME TIME NEWSPAPERSThe Cove, 606 W Cypress St.: Fish tacos and burgers are the food draw. On the music side, there's everything from jazz to folk, from rock 'n' roll to gospel. And the Cove has a large beer and wine selection plus enough space for families and music fans to peacefully coexist.
Billboard Magazine names three Texas music venues in its list of "25 Most Popular Music Clubs in the U.S.," which includes a lesser-known Austin hotspot.
Click through the slideshow to see 25 Texas dance halls still operating.
Photo By Courtesy of RepublicRanches.comThe number of Texas dance halls is dwindling around the state, but the tradition still lives on.
Click through the slideshow to see 25 Texas dance halls still in operation.
Martinez Social Club - 7791 Farm to Market 1346, San Antonio
Photo By BILLY CALZADA/SAN ANTONIO EXPRESS-NEWSQuihi Gun Club - 260 County Road 4518, Hondo
Photo By Photo courtesy Vanessa GavalyaGruene Hall - 1281 Gruene Rd, New Braunfels
Photo By Kendalia HalleKendalia Halle - 1135 FM 3351 N., Kendalia, 210-863-1100
Photo By Bob Owen/San Antonio Express-NewsBraun Hall - 9721 Braun Road, San Antonio
Photo By Courtesy photoAnhalt Hall - 2390 Anhalt Road, Spring Branch
Photo By Edward A. Ornelas/San Antonio Express-NewsMesquite Trail Drivers Hall and Arena - 11663 Ford Road, Adkins
Photo By Twin Sisters Hall ClubTwin Sisters Hall Club - 6720 U.S. 218 S., Blanco
Photo By Courtesy of RepublicRanches.comSchroeder Hall - 12516 FM 622, Goliad
Photo By Melissa Ward AguilarArkey Blue's Silver Dollar Saloon – 308 Main, Bandera
Photo By Kristin FinanBilly Bob's Texas - 2520 Rodeo Plaza, Fort Worth
Fischer Dance Hall - 115 Fischer Store Road, Fischer
Photo By Fred Bunch/Houston ChronicleGilley's Dallas - 1135 S Lamar St, Dallas
Photo By Express-News file photosFloore's Country Store - 14464 Old Bandera Road, Helotes
Photo By ROBERT JOHNSON/SAN ANTONIO EXPRESS-NEWSFreiheit Country Store - 2157 Farm to Market Road 1101, New Braunfels
Hangin' Tree Saloon - 18424 2nd St., Bracken
Photo By TOM REEL/SAN ANTONIO EXPRESS-NEWSLeon Springs Dance Hall - 24135 I-10 West, San Antonio
Luckenbach Dance Hall - 412 Luckenbach Town Loop, Fredericksburg
SAN ANTONIO – It's no secret that Austin is famous for its live music venues, but one popular joint ranks among the best in the nation.
Stubb's Bar-B-Q on Red River Street was ranked 25th by Billboard Magazine in its 25 Most Popular Music Clubs in the U.S. list.
Not bad for the restaurant that started as a barbecue restaurant in Lubbock, and soon, it will host shows for Tegan and Sara, Coheed and Cambria and Skrillex.
"At famed restaurant and concert venue Stubb's, nothing brings people together like good barbecue -- or like the recently renovated Airstream trailer out back," the Billboard website states.
The list is based on attendance reported to the Billboard Boxscore from May 1, 2013 to April 20.
Stubb's was the only venue in Austin on the list at 116,582 attendees during the time period, falling short to the famous House of Blues venues, which sweep the top spots.
The House of Blues in Dallas ranked fourth on the list with 222,988 attendees, after the House of Blues in Orlando and Boston and the 9:30 Club in Washington, D.C. The House of Blues in Houston ranked sixth on the list with 209,299 attendees.
Click through the gallery to see other live music venues in the state.


text:
Show and hide ID elements with a mouseclick. Could be used to create for example menus or menu tabs.
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You must log in to submit a review. You can also log in or register using the form near the top of this page.


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I'm an outings leader with Sierra Club and a volunteer instructor for theWilderness Travel Course in Orange County.
I enjoy climbing in the Sierra whenever I have a scrap of free time andparticularly enjoy the more technical trips.
To submit your contact info, please fill in the Roster Entry form or contact the webmaster.


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I'm a YouTuber that goes by the name of Cryssy over the interwebz (and subsequently this is also my paladins name!), however I am here to let you know of a little contest I am holding!
I received an extra Virtual Gift card at BlizzCon 2013 this year! So, as a result I am holding a giveaway on my channel for this card! It gives you a mystery HearthStone card, a pet in World of Warcraft named Murkalot, A Mark of Death banner in Diablo III, and a portrait and decal for Starcraft II. The winner will be randomly selected, and the rules are pretty simple.
The video for the contest can be seen here:
Here is a brief summary of the rules!
1. Like the video!
2. Favourite the video!
3. Comment on the video! (very important step)
4. Subscribe to my channel!
If you like WoW parodies, raiding content, BlizzCon footage and general tom foolery then I'm sure you'll love my content!
Good luck everyone!
BlizzCon 2013 Virtual Gift YouTube Contest!
Posted 14 November 2013 - 03:47 AM
Also tagged with one or more of these keywords: Contest, YouTube, BlizzCon, Code Redemption, Virtual Gift, In Game Pets, BlizzCon 2013, Cryssy
World of Warcraft Discussion →
General Discussion →
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Check out some Orc Shaman videos! Good music and relaxed atmoshpere!
Started by Guest_Soulexite_* , 24 Apr 2014 World of warcraft, wow and 6 more...
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text:
By Rich Pope, Department of Plant Pathology
Soybean fields are now starting to senesce, and corn is filling well. The latest USDA crop forecast projected a 187 bushel per acre average for corn yields, and 52 bushels per acre for the beans. Both would be great accomplishments considering the wet spring and cool summer. As of Sept. 13, we are lagging for the season an "average" accumulation of between 300 and 400 degree days, which rivals the 1992 growing season.
Average temperatures and clear, sunny days the next two to three weeks are still the ideal for Iowa crops. Soybean aphids are still persisting with sizeable populations in some fields, but in Ames we are seeing winged aphids fully engaged in the migration to buckthorn for overwintering. Nearly all soybeans well past the point of gaining benefit from treatment to control aphids.
Regardless of how the season finishes, wet grain, especially corn, is highly likely. That is all the more reason to ensure harvest equipment is properly adjusted and that grain is handled properly during and after binning.
Rich Pope is a program specialist with responsibilities with Integrated Pest Management. Pope can be contacted at firstname.lastname@example.com or by calling (515) 294-5899.
This article was published originally on 9/15/2009 The information contained within the article may or may not be up to date depending on when you are accessing the information.
Links to this material are strongly encouraged. This article may be republished without further permission if it is published as written and includes credit to the author, Integrated Crop Management News and Iowa State University Extension. Prior permission from the author is required if this article is republished in any other manner.
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Last Updated 9/15/2009


text:
Walker Machinery parent buys Caterpillar business
BELLE, W.Va. (AP) -- The parent company of Walker Machinery is buying part of the mining equipment distribution and support business of Caterpillar Inc.
Illinois-based Caterpillar said Thursday that Kentucky-based Boyd Company LLC has acquired Caterpillar's Bucyrus equipment distribution and support business for its territories.
The company has established Whayne-Walker Underground Mining as a new business unit to meet the distribution and support needs.
Whayne Supply Co. and Cecil I. Walker Machinery Co. are authorized Cat dealers in Kentucky, southern Indiana, southeastern Ohio and parts of West Virginia.
The Charleston Gazette reports that Caterpillar has announced similar transactions with other dealers over the last several months.
Belle-based Walker Machinery had been run by the Walker family since 1959. It completed the sale of its mining equipment business to Boyd Co. in April 2010.


text:
Open a wide range of practical and creative options by learning how to add spot colors and varnishes to your print designs.
Introduces the printing process, from choosing the correct paper, inks, colors, and fonts and correctly laying out the project in Illustrator and InDesign to getting the final product from the printing press floor.
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Posted at: 07/16/2013 8:35 AM
By: Elizabeth Reed, KOB.com
UnitedHealthcare Group and the state of New Mexico will host a job fair on Tuesday, July 16.
The company is looking to fill about 100 jobs, like claims representatives and customer care workers.
The job fair takes place at the Marriot hotel located at 5151 San Francisco Rd. NE. The event lasts from 10 a.m. to 6 p.m. and will be open to the public.


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What You Should Know
|Star Rating
|2 or More Patented Ingredients
|Less Than $5 Shipping
|Trial Offer
|Rejuval Skin (2014 Editors Choice)
|Facial Toner
|IQ Derma
|Epicuren Discovery Instantlift Facial Cream
|Meaningful Beauty
Your skin's age, type and condition are very important. Especially when you are searching to find a skincare treatment or remedy of some sort. Naturally you want to acquire a product that caters to your skin type and condition. This is why it pays to shop around and do a little research. One line that you may want to consider is Epicuren. If you are not familiar with this brand, it may be due to the fact that it is not commonly available in stores. If you take a look at the official website, you will see a dealer locator apparatus. This allows you to find out if any Epicuren distributors are located nearby. Just so you know, Epicuren products are not sold through the primary website. One of the products offered from this line is Epicuren Discovery Instantlift Facial Cream. Like many other products on the market today, this formula is claimed to assist with anti-aging.
Product Details
Epicuren Discovery Instantlift Facial Cream is basically a topical face moisturizer that is claimed to improve skin firmness, tone, and texture. It sells for $90 (1.7 fluid ounces), and is geared toward women with mature skin. It should be applied daily to clean facial skin. This topical treatment contains a combination of Plant Molecules that assist the skin in different ways. Some of these plant extracts are Jojoba Oil (hydrates and smoothes skin), Vitamin E (heals and nourishes skin), Rosemary Extract (calms skin), Kukui Nut Oil, Aloe Vera (helps heal), and Bearberry Extract.
Here is a complete list of ingredients for this product: Purified water, glycerin, sweet almond oil, polyacrylamide, evening primrose oil, aloe vera, macadamia nut oil, kukui nut oil, jojoba oil, wild thyme and dipalmitoyl hydroxproline, essential oils, rosemary extract, bearberry extract, cinnamon extract, grapefruit seed extract, and tocopheryl acetate (vitamin E).
The Good
- There are a variety of natural extracts found in Epicuren Discovery Instantlift Facial Cream.
- All of the ingredients for this product are posted online.
The Bad
- This product cannot be purchased through the official website.
- Epicuren Discovery Instantlift Facial Cream is not commonly available in department stores.
- There is no customer feedback for this topical anti-aging cream.
- It is pretty expensive at $90 per bottle.
The Bottom Line
All in all, Epicuren Discovery Instantlift Facial Cream is one of many anti-aging products that is claimed to firm and tone skin. While this topical formula certainly offers a good compilation of nut oils and plant extracts, there are really not any well-known anti-wrinkle ingredients found in it. Also, Epicuren Discovery Instantlift Facial Cream is difficult to come by. If a spa or distributor is not located in your area, you will unlikely be able to purchase this face treatment.


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Self Protection
Ben Branam was born in California and moved to Austin in 2004. Four months ago, he moved to San Antonio to help start a church and pursue his own business, Modern Self Protection. Ben spent 10 years in the Marine Corps, did a combat tour in Iraq, spent a year as part of an anti-terrorist company, and taught anti-terrorism, shooting, and advance combat skills. He left to take a job as a private contractor for the Army in Iraq.
Monthly Archive for August, 2010
Are You in Danger While Talking to a Cop?
An interaction with a police officer could be dangerous. Sounds wrong? It's true. A police officer is always looking for a bad guy and may not know that you are a good guy. You could be carrying something that scares that particular officer. Example: I've carried a gun my entire life and mostly made my […] [Read More]


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The Food Lab: For the Best Baba Ganoush, Go For a Spin
I used to hate all things eggplant. Until I had my first taste of really great baba ganoush. It was made by a good friend of mine, an Israeli line cook who'd take time out of her afternoon to hover over the eggplants slowly charring over the open flames of the kitchen's burners, waiting until they were meltingly tender, before recruiting me to carefully peel them before she'd mix them up with lemon juice, tahini, garlic, and olive oil. The resulting dip was simultaneously smoky, savory, bright, and creamy...and I was addicted. More


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Living in St. Peter
Pertinent Laws
As students of Gustavus, you are citizens of St. Peter and, therefore, the St. Peter Police Department is your law enforcement agency. If you have been the victim of a crime, have any questions about the city or its laws, or have any reason to need the services of a law enforcement agency, please feel free to call the St. Peter Public Police Department any time, day or night, at 507-931-1550. Below are a few laws and regulations that are likely to affect you during the time you are attending Gustavus.
Violation of parking regulations will result in issuance of a parking ticket or towing of the illegally parked vehicle. General parking prohibitions (within ten feet of a fire hydrant, on a sidewalk, double parking, etc.) are in effect; and in addition, the city has an ordinance making on-street parking for a continuous period in excess of 24 hours unlawful.
Parking on 7th Street between Jefferson and Grace Streets and on Capital Drive is limited to those with a St. Peter City parking permit.
Snow Emergencies
Members of the Gustavus community who live or park vehicles off-campus should also be aware that the City of St. Peter enforces a Snow Emergency ordinance. Anytime there is an accumulation of snow (2–3 inches) or ice that is likely to impede traffic, a 48-hour Snow Emergency will be declared. Once a Snow Emergency is declared, there is no parking on any of the posted Snow Emergency Routes for the entire 48-hour period. Beginning at midnight, for two days, there is no parking on residential streets midnight–7 a.m. Beginning at 2 a.m., for two days, there is no parking on downtown streets from 2 to 6 a.m. Vehicles not removed from the streets during the enforcement period may be tagged and towed. Snow Emergencies will always be declared before 5 p.m. When it snows, call the city information line at 934-0675 for updated snow emergency information. Local radio station KRBI (FM 105.5) is also notified when a snow emergency is declared. KRBI may then report it on the air. Snow Emergencies are declared by the City of Saint Peter. You can sign up to be notified of snow emergencies through the Nixle web page, more information is available on the City of Saint Peter web page:
Any party that intrudes upon the rights of other community members is in violation of city ordinances. Such ordinances are also enforced at the city's parks.
There are two ordinances that may be of particular interest to the Gustavus community. The first is an unlawful assembly ordinance. This ordinance makes excessive noise generated by groups of three or more persons from 10 p.m. to 8 a.m. (and audible at the property line or an adjacent residence, or at a distance of 50 feet if outdoors) a misdemeanor and gives the police authority to order people to leave the assembly.
The second ordinance applies to possession or consumption of alcohol in city parks. A permit is required for a person or group (any group, including departmental picnics arranged by faculty) to have hard liquor, a keg, quantities of wine greater than a gallon, or quantities of beer more than one 24-unit case in any of St. Peter's parks (e.g., Minnesota Square, Levee Park, Gorman Park). A cleanup deposit of between $40 and $200 must accompany each permit application. Under the ordinance, the Police Department has the authority to eject any person or persons acting in violation and to confiscate and dispose of the alcoholic beverage involved. The permit may be immediately revoked upon violation of any park rule or permit condition. As with the unlawful assembly ordinance, violation is a misdemeanor and may result in arrests and/or fines.
In addition, a rental property ordinance authorizes sanctions including rental certificate revocation against rental property owners whose tenants are repeatedly cited for unlawful assembly or disorderly house.
All traffic laws apply, including those requiring proper lighting for night use. St. Peter has a fairly strong and active bicycle-licensing program. It's a good idea to obtain a license here if your bicycle is not already registered.
Legal Drinking Age
The 21-year old drinking age is enforced in St. Peter. Both the State of Minnesota and the City of St. Peter have developed legislation making it unlawful: a) for minors to consume, purchase, or possess alcoholic beverages; to misrepresent their age or use false ID in order to purchase; or to enter licensed premises except to consume a meal; b) for legal-age persons to provide alcohol for minors or to induce minors to purchase or procure; or c) for any person to sell alcohol without a license. (See also the Alcohol Policy.) The city also regulates consumption in parks and public spaces (see above information).
Airport Shuttle Service
Students may purchase tickets at the Information Desk and make guaranteed reservations for Mankato Land to Air Express airport shuttle at a discounted price. Multiple trips are made daily between the Minneapolis-St. Paul International airport and the St. Peter Food Coop, located in downtown St. Peter. Additionally, students may purchase tickets by calling Land to Air Express directly at (507) 625-3977 or 1-888-736-9190, or by paying the driver directly. Discount price does not apply if purchase is made through Land to Air. For further convenience, students may request to be picked up or dropped off at Three Flags on the Gustavus campus. For additional information visit: www.landtoairexpress.com.
St. Peter has four financial institutions (First National Bank, Nicollet County Bank, Community Bank, and a local office of Wells Federal Bank), should you wish to establish a local account. However, as is the case in most college communities, St. Peter businesses are very good about accepting student hometown checks. In addition, three of the banks have cash card machines in their 24-hour lobbies and two have installed ATM machines specifically for the College community in the Campus Center.
Bus Transportation
St. Peter offers a local bus station for Jefferson lines, which schedules north- and southbound passenger service daily. Students may connect to other carriers at Mankato or the Twin Cities. Schedule, rate, and stop location information is available by phone (800-451-5333) or online at http://www.jeffersonlines.com/.
St. Peter Transit Service
City Transit provides door-to-door passenger service in St. Peter. Dial 507-934-6070 to arrange for pickup.It also operates a route system that stops on campus at 3 Flags - Monday through Friday. Discounted transit tickets are available for purchase at the Information Desk and may be purchased in advance. Tickets purchased directly from the transit driver are not discounted.. Service hours for St. Peter destinations are as follows:
- Monday–Friday 7 a.m.–8 p.m.
- Saturday 10 a.m.–5 p.m.
(The transit does not run on Sundays. Cost and times are subject to change.)
Gustavus students may obtain an absentee ballot from their permanent home district or vote locally. Students who wish to vote locally and have not already registered may do so at the polls on any election day. The Gustavus campus falls into different wards and precincts; to learn which precinct your residence is in, check with the Office of Residential Life or look for notices posted prior to election days.


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About this Artist
Versus Them
Matt Montgomery
Isaac Yates
John Varn
Marin County's own Versus Them combines original, harmony-infused songwriting with a powerful piano-driven rock ensemble. Their unique and original songs create a refreshingly lovable sound. VsThem has played shows with notable local acts such as Judgment Day, The Johnny Keigwin Band, Birds and Batteries, and also at NoisePop shows throughout the Bay Area. VsThem's influences include Rufus Wainwright, Muse, and The Beach Boys, which shows through in the range of the band's songs. Witness Versus Them change the musical landscape forever. ARE YOU WITH US?
We don't have any upcoming shows listed for this artist right now.


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Pegatron to Ship Low Cost iPhone, New iPad Mini in August?
Pegatron has reportedly landed orders for the low cost iPhone with plastic chassis and the next generation iPad mini, reports DigiTimes. The company is set to begin shipments in August, according to Taiwan-based suppliers.
The upstream supply chain will start shipping components for the new iPad mini and iPhone in July and players such as chassis supplier Casetek are expected to strongly benefit from the orders. A next-generation iPhone and 9.7-inch iPad reportedly will appear in early 2014 and will be manufactured by Foxconn Electronics (Hon Hai Precision Industry).
Notably, Macokatara recently reported that iPhone 5S and the new iPad mini would be released in August. They also indicated that the low cost iPhone would come in a variety of colors.
Read More


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- 7 function - auto range
- Tests up to 500 VAC, 600 VDC and 20M ohm resistance
- Protecitive rubber boot with magnetic strap
- Diode transistor checker
- Transistor checker
- Temperature check to 2498 deg. F
- Continuity buzzer
- Fuse protected with test and temperature leads
- Replacement 250MA fuse Ace No. 3193281
- Replacement leads Ace no. 3268851
*Items shipped from our warehouse to stores in Alaska and Hawaii will receive a 70% shipping discount.
30-Day Return Guarantee
We want you to be fully satisfied with every item that you purchase from www.acehardware.com. If you are not satisfied with an item that you have purchased (excluding Gift Cards and gas-powered outdoor equipment*), you may return the item up to thirty days after the original purchase date to receive a store credit (less shipping, handling and other charges). We recommend that you make returns of online purchases to an Ace retail store near you which will issue your store credit. If you do not have an Ace retail store near you, please contact a Customer Service Specialist by calling 1-866-290-5334 for complete return instructions. Please refer to our Return Instructions for more information about returning a purchase.
The item must be returned in good condition, in original boxes (whenever possible), and with all paperwork, parts and accessories to insure full credit. After 30 days, please contact the manufacturer directly.
*Gas-Powered Outdoor Equipment cannot be returned once gas or oil has been put in it, even if the Equipment has been drained of these materials.
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temp probe is 10+ degrees off, so if using this on air conditioning or heaters, no good for that, battery voltage test, tested the same battery 5 times and got 3 different readings.
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Comments about GB ELECTRICAL GB® Digital Multimeter (GDT-3200):
This is the easiest tester I've ever used in my 45 yrs. of auto & home electrical repairs.


text: Best Coast dropped in on Late Night with Jimmy Fallon last night to play "Storms," the bonus Fleetwood Mac cover from their recent album The Only Place. Bethany Consentino and Bobb Bruno were joined by only a bassist on the dark stage for a performance that was quiet save for Constentino's impressive voice. "Never have I been a blue calm sea, I've always been a storm," she sang, staid like we don't often get to hear her and channeling her inner Stevie Nicks in a floor-skimming black dress and turquoise jewelry. Best Coast's take is a bit more somber than the original Tusk b-side, but no less beautiful for it. Nicks, we have to believe, would approve.


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with Tim Frame
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with Molly Murrah
with Megan Auman
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Live Oak County Airport gets funding for improvements
CORPUS CHRISTI - Live Oak County Airport will receive $120,000 for improvements after the Texas Transportation Commission approved the funding at its June meeting.
Improvements will include more than 15,000 feet of game fencing around the airport, eight gates, land clearing and demolition of barbed wire fencing, the Texas Department of Transportation announced in a news release.
Ninety percent of the project costs will be funded by the transportation department's Aviation Facilities Grant Program, and 10 percent by the county.
The department expects to spend about $60 million planning, constructing and maintaining community airports this year. About 275 community airports in Texas are eligible for funding.
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This book contains a delightful collection of short articles, several of which have appeared in various German magazines. The author is a mathematician and journalist who covers Israel and the Middle East for the Swiss daily newspaper Neue Zürcher Zeitung and for which he also writes a monthly column on mathematics. The author of Kepler's Conjecture (2003), Szpiro has an MBA from Stanford and a doctorate in finance and mathematical economics from the Hebrew University of Jerusalem.
The stories collected in this Medley are aimed at general readers with an interest in mathematics and science. They are very interesting and well written but do not have the mathematical depth of articles by Martin Gardiner or Ivars Peterson. Some references to further reading and sources are included at the end (the references to Chapter 10 are out of sequence). The articles have been partitioned into the following sections:
Of special interest are the articles on the Littlewood-Salem-Izumi constant, Ramanujan's mock theta functions, Hales's proof of Kepler's conjecture, Green and Tao's work on arithmetic series of prime numbers, stamp and coin problems, queues, Tao's shoelace problem, Benford's law, airline boarding policies, Braess' traffic planning paradox, dyscalculia, the Whorfian hypothesis, Sudoku, the triangle-avoidance game, Nash equilibria, Talmudic division, Borda counting, the aggregate probabilities principle, Wolfram and cellular automata, a Gaussian copula function and bankruptcy, deciphering the Voynich manuscript, and the variability of fractal dimension in Jackson Pollock's paintings.
A more precise reference for the origin of a J. J. Sylvester letter could have been included (p. 40). The most frustrating omission, however, is the lack of an index. In any case, readers will learn about many interesting recent applications of and results in mathematics as well as find out about a number of dedicated mathematicians they may have never read about before.
Jim Tattersall is Professor of Mathematics at Providence College, in Providence, RI.
A baker's dozen
Math for math's sake
Math applied to real life
In the air
Training the brain
Games, gifts, and other diversions
Choosing and dividing
Money, and making it
Interdisciplinary matters


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After running Ajax Union for more than six years and servicing over 1,000 small businesses, I can confidently say that I've made plenty of mistakes, learned from them, and continue to strive for company-improvement.
I've been blessed with the ability to help countless companies see growth and learned from many business owners in my personal networking endeavors.
In my conversations, I learned that many entrepreneurs feel similarly about starting on a new business venture. It's a juxtaposed feeling of excitement and fear, a thrilling mix of what can be and what might happen.
Although there are countless tips I wish I'd known, I've boiled it down to three things that will help you get a head start on your business.
Clear realistic goals: When I started our company with my partner, Zevi Friedman, we had one goal: to grow the business to one million dollars in revenue.
We also wanted to make ourselves available to service 34 million small businesses in the United States.
Looking back now, we hit that million dollar revenue mark pretty quickly.
But, we would have gotten there faster if we had narrowed our focus and set a more realistic goal.
The more we defined our goals as the years went on, the more clarity and motivation we had.
Setting clear, realistic goals is a must-have. Your goals need to be specific, measurable, attainable, relevant, and timely. They must also have straight-forward action items attached that can point you in the direction of achieving your mission.
When I mentor business owners today that are just getting started, I always ask them, "How much revenue do you want to make next year?" And, too often, the answer I hear back is "As much as possible!"
While it's a lofty ambition, this isn't a realistic goal. Instead, a better answer should dictate not only a feasible amount that your company can make, but also outline your yellow-brick-road to success.
A better answer: "I'd like to generate three million dollars to my clothing location in Soho in the next nine months. I plan to host social media contests and monthly in-store events to boost traffic and generate 15 percent of my bottom line."
People are everything: When you are growing a business and are stuck in the early stages, it's often challenging to focus all your energies on hiring A-game people right off the bat.
But, from experience, I have found that finding people that want to learn and grow with your company, and not outgrow your start-up, is essential to future success at this first stage.
Most hiring executives are looking for people to execute their vision. They are easily sold on anyone that displays the same passion and level of excitement that they have towards their company.
But, not everyone you hire will be a good fit, and I learned to stick to the idea of "hire slow, fire fast". When we were getting started, we wanted to give everyone that was willing to learn a fair starting chance.
However, people sometimes get stuck in positions that they're not really excited about, and it's important to make sure that you don't have teammembers on board that may be weighing down your business.
I'm also a firm-believer in the "hire for attitude, train for skill" strategy. If you want to get your people to have a better attitude, be sure to hire them that way.
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Walker & Reibold
Walker & Reibold, LLC is primarily a civil litigation firm that traces its roots to 1992. The firm is rated "AV" by Martindale-Hubbell, and is currently staffed by five attorneys and support staff.
Our attorneys have developed a practical approach to resolving disputes. This has led to continued growth as clients have seen the value they receive as a result of our efforts. Much of this growth is in products liability and employment practices litigation.
"CV, BV and AV are registered certification marks of Reed Elsevier Properties, Inc., used in accordance with the Martindale-Hubbell certification procedures, standards and policies."
"Martindale-Hubbell is the facilitator of a peer review rating process. Ratings reflect the confidential opinions of members of the Bar and the Judiciary. Martindale-Hubbell Ratings fall into two categories - legal ability and general ethical standards."
H. Clayton Walker, Jr - Managing Partner


text: The Avalanche had such a nice blueprint for this season. The team had banked another year of maturity for its young core players from a close-call run at the playoffs last season. The Avs would put to use their lessons learned from that experience. This season, they would find a way inside the velvet ropes containing the top eight playoff teams and finally start to reclaim some of their proud heritage.


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RightSize Retail Locations
A limited selection of our products can be found at the following retailers. While we are carried by these stores, we often do not know what specific locations will have our products. Please call the location nearest to you to confirm they carry RightSize Powder Smoothie Mix.
Look for RightSize at these fine retailers:
- Walgreens (select locations)
- Shop 'N Save
- Albertson's
- Jewel-Osco
- Acme
- Cub
- Shoppers
- Farm Fresh
- Meijer
- Shaw's
- Pathmark
- HyVee
- Harris Teeter
*Please note that products purchased on the web cannot be returned to a retail location or vice versa. The smoothie powders sold in our retail stores are in a 20 serving can as opposed to the 30 serving cans we offer online. We do not control retailers return policies, nor are we often aware of specials or promotions that they choose to run on our product. We also do not set retail pricing, so there can be variation between retailers.


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Mar 2, 2009 2
Rally to Save the NRO
Politics makes seemingly strange bedfellows. But alliances are always based on interests.
Pervez Musharraf and Asif Zardari called Altaf Hussain to give him props on yesterday's rally to protest the desecration of Benazir Bhutto's posters (which was vigorously condemned by Nawaz Sharif several days earlier).
There are also reports that last week Musharraf called Zardari after meeting with some Sindhi politicians to boost support for the Mr. 100% (Zardari). Musharraf reportedly asked Pir Pagaro to coax Yousuf Raza Gilani, a relative, not to cause Zardari trouble.
It all makes sense: Zardari is certainly following in the footsteps of the Musharraf of 2007, which, I think was the Chinese year of the [dumb] ass. Nawaz Sharif was right today when he said, "It appears as if the spirit of Musharraf has entered Zardari." This is not a partisan argument. There are quite a few senior PPP figures who believe the same.
Interestingly, Ahmed Raza Kasuri is also on the same page as Musharraf and Zardari. That would certainly make Zulfikar Ali Bhutto happy.
The real danger from Zardari going down is that the PPP is unlikely to rise again. And that would be a major blow to Pakistan's quest for political stability. The PPP is flawed and internally undemocratic, but it is a national institution and a important pillar for domestic stability.


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Product Menu
Medals of America is your premier source for Military Medals, Badges, Patches, Challenge Coins, Rank, Rates and Insignia, as well as great military clothing. Our apparel includes military hats, shirts, jackets and more! Most of our clothing products can be Custom Embroidered, so you can make your clothing one-of-a-kind.
We are proud to offer our exclusive Free Custom Builders, including our Ribbon Rack Builder, Military Medals Builder, Custom Display Case Builder and Custom Garment Builders.
Medals of America is Veteran owned and operated for more than 35 years! Our mission is simple - we want every Veteran and Service person to display the Medals our grateful Nation awarded them.
Coast Guard Medal
Full Size, Standard Finish - USCG (Coast Guard) MedalInstituted: 1958Criteria: Heroism not involving actual conflict with an armed enemy of the US.


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The Clunie House
An elaborate Victorian mansion, the Clunie House is located on "The Panhandle" of Golden Gate Park, a few blocks from the famous Haight-Ashbury neighborhood. Its unique setting offers students the chance to become fully immersed in city life and culture.
The house is centrally located in the City; only three miles from downtown and four miles from the Pacific Ocean. Close to several public transportation options, Westmont in San Francisco is located is in a prime location for exploring the City's many attractions and commuting to various internship sites. The Haight-Ashbury, Inner Sunset, Inner Richmond, Japantown, Pacific Heights and Castro districts are minutes away. Directly across the street is the beginning of Golden Gate Park, which offers green space for outdoor recreation. With the city of San Francisco at your front door, the possibilities are endless!
Student Rooms & House Features
Click here to see the layout of each floor of the Clunie house. The house has eleven unique Victorian-style bedrooms, each with their own full bathroom. Each room houses 2-3 people, and contains an individual desk, closet and drawers for each person.
The house has wireless access to the internet. Computers and printers are available; students only need to provide printer paper. There is a DVD/VCR player and projector available in the classroom. Additionally, there are bikes, sporting equipment, board games, and a piano available for student use.
A Foodie's Kitchen
As San Francisco is a leading city in the local food movement, the kitchen is stocked with fresh, organic, and fairly-traded products as much as possible. A variety of food options are provided, accommodating student requests and individual dietary needs. Students have the opportunity to cook their own meals in a state-of-the-art kitchen that has a communal vibe. A "foodie" city, there are endless restaurants to try during a semester in San Francisco.
Once a week, students and staff participate in Community Dinner, when a group of students create a meal for the community.
Conference Use
The Clunie House is available for conference use during the summer and academic breaks, with space for housing and/or meeting space. Food service and electronic support is also available. Contact firstname.lastname@example.com for more information on rates and availability.


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. Great lot ready to be built on! Convenient to Dave Lyle Blvd.More info
. Industrial district with a myriad of possible uses including mini warehouse; truck terminal; generaMore info
. Nice piece of property. 12+ acres. Wooded. Clean fill was added at the front of the property in theMore info
. York County water is available within . 25 miles and can be connected for a fee according to York CMore info
. Nice wooded tract of land close to the interstate and also has a large 3 car shop with bonus room aMore info
. This land fronts on the Catawba River. Water and Sewer at Mt Gallant RdMore info