text:
This invention relates to apparatus and methods for use in sealing a vascular puncture site and to apparatus and methods for properly locating and deploying a sealing device. The locating apparatus comprises a lumen which extends from an opening in the distal region of the apparatus but located proximally of the sealing device, which lumen extends to another opening in the proximal region of the device. When the distal opening is in communication with blood in a blood vessel, blood flow through the lumen and out of the proximal opening signifies such location to the user. When the sealing device is withdrawn such that the sealing device is deployed such that it blocks the blood flow into the distal port, the user will know the location of the sealing device. In a preferred embodiment, the sealing device is then withdrawn proximally a predetermined distance to assure that no part of the sealing device extends into the blood vessel lumen. The sealing device is then detached from the delivery device.
1. A locator device comprising
an elongate member, said elongate member having a distal opening and a
proximal opening which are connected by a lumen,
said elongate member being adapted to extend into a blood vessel of a patient such that said distal opening is located in the lumen of the blood vessel and such that blood flow through said proximal opening is visible outside of the patient's body, and
said device being provided with an occlusion member located distally of said distal opening, said occlusion member being capable of substantially blocking blood flow out of said blood vessel when it is withdrawn from said blood vessel lumen.
2. The device of
3. The device of
4. The device of
5. The method of installing a closure device adjacent to, but outside of a puncture in a blood vessel wall comprising the steps of
introducing an elongate member through a tract extending from said puncture to the patient's skin, said elongate member having a first opening in its distal region, a second opening in its proximal region and a lumen extending between said first opening and said second opening,
said elongate member being provided with an occlusion member located distally of said first opening,
advancing said elongate member until said first opening is located within the lumen of said blood vessel such that blood flows into said first opening and not out of said second opening, and
withdrawing said elongate member until the flow of blood into said first opening is substantially prevented.
6. The method of
7. The method of
The present invention relates generally to apparatus and methods for sealing or closing passages through tissue, and more particularly to devices for sealing punctures or other openings communicating with body lumens, such as blood vessels, and to apparatus and methods for delivering such devices.
Catheterization and interventional procedures, such as angioplasty or stenting, generally are performed by inserting a hollow needle through a patient's skin and muscle tissue into the vascular system. A guide wire may then be passed through the needle lumen into the patient's blood vessel accessed by the needle. The needle may be removed, and an introducer sheath may be advanced over the guide wire into the vessel, e.g., in conjunction with or subsequent to a dilator. A catheter or other device may then be advanced through a lumen of the introducer sheath and over the guide wire into a position for performing a medical procedure. Thus, the introducer sheath may facilitate introduction of various devices into the vessel, while minimizing trauma to the vessel wall and/or minimizing blood loss during a procedure.
Upon completion of the procedure, the devices and introducer sheath may be removed, leaving a puncture site in the vessel wall. External pressure may be applied to the puncture site until clotting and wound sealing occur. This procedure, however, may be time consuming and expensive, requiring as much as an hour of a physician's or nurse's time. It is also uncomfortable for the patient, and requires that the patient remain immobilized in the operating room, catheter lab, or holding area. In addition, a risk of hematoma exists from bleeding before hemostasis occurs.
Various apparatus have been suggested for percutaneously sealing a vascular puncture by occluding the puncture site. For example, U.S. Pat. Nos. 5,192,302 and 5,222,974, issued to Kensey et al., describe the use of a biodegradable plug that may be delivered through an introducer sheath into a puncture site. When deployed, the plug may seal the vessel and provide hemostasis. Such devices, however, may be difficult to position properly with respect to the vessel, which may be particularly significant since it is generally undesirable to expose the plug material, e.g., collagen, within the bloodstream, where it may float downstream and risk causing an embolism.
Another technique has been suggested that involves percutaneously suturing the puncture site, such as that disclosed in U.S. Pat. No. 5,304,184, issued to Hathaway et al. Percutaneous suturing devices, however, may require significant skill by the user, and may be mechanically complex and expensive to manufacture.
Staples and surgical clips have also been suggested for closing wounds or other openings in tissue. For example, U.S. Pat. Nos. 5,007,921 and 5,026,390, issued to Brown, disclose staples that may be used to close a wound or incision. In one embodiment, an "S" shaped staple is disclosed that includes barbs that may be engaged into tissue on either side of the wound. In another embodiment, a ring-shaped staple is disclosed that includes barbs that project from the ring. These staples, however, have a large cross-sectional profile and therefore may not be easy to deliver through a percutaneous site to close an opening in a vessel wall.
In addition, skin seals have been proposed that may be threaded into an opening in skin. For example, U.S. Pat. No. 5,645,565, issued to Rudd et al., discloses a surgical plug that may be screwed into a puncture to seal the puncture. The surgical plug includes an enlarged cap and a threaded shaft that extends from the cap. During an endoscopic procedure, the plug may be threaded into an opening through skin until the cap engages the surface of the skin. The plug is intended to seal the opening communicating with a body cavity to prevent insufflation fluid from leaking from the cavity. Such plugs, however, may only be used at the surface of the skin, and may not be introduced through tissue, for example, to seal an opening in the wall of a-blood vessel or other subcutaneous region.
Various methods and means for determining the location of the distal end of a closure device have been proposed, including "bleedback" methodology such as that disclosed in U.S. Pat. No. 4,738,658 issued to Magro et al. However, prior bleedback devices have been constructed such that blood flow out of the patient continues for a longer period of time during deployment of the sealing means than would be desirable. Thus, a need exists for a closure device with a bleedback locator feature which reduces the amount of time during which blood flows out of the patient during deployment of a sealing member.
The present invention is directed to a device which is capable of both locating a punctured blood vessel and sealing the puncture in the vessel and to the method of using the device as well. This device makes use of a "bleed back" feature, but, unlike known bleed back devices, uses a shut-off feature to deploy a sealing element at the desired location. In a preferred embodiment, the device of the present invention comprises an elongate member having a lumen extending from a point in the distal region to a point in its proximal region. The lumen is connected at its proximal and distal regions to proximal and distal ports in the elongate member which create a conduit from the lumen to the outer surface of the elongate member. In this embodiment, the elongate member is also provided with a detachable sealing element which is attached to the elongate member distally of its distal port. The sealing element may be a bioabsorbable felt or other suitable material. The proximal and distal ports are spaced sufficiently far apart that the proximal port is outside the patient's body when the distal port is within the lumen of the punctured blood vessel.
In an alternative embodiment, a groove in the outer wall of the elongate member or in the inner wall of a tubular member, such as an introducer sheath, which runs from the distal region of the elongate member to the proximal region thereof is provided proximal to the sealing element such that blood can flow through the groove when the distal end of the groove is in communication with the blood in a blood vessel.
In use, the device of the present invention can be used to close a puncture wound such as that in a femoral artery after a catheterization procedure has been performed. Typically, the device of the present invention will be introduced through an introducer sheath used in the catheterization procedure. When so used, the device is passed through the introducer sheath until the sealing element of its distal end and the distal port or distal opening of a groove are within the lumen of the femoral artery. The user will know when this has occurred when blood emerges from the proximal port or proximal end of a groove since this will occur when the distal port or distal end of a groove reaches the lumen of a blood vessel such as the femoral artery. Once this occurs, the device is withdrawn a short distance until the sealing element is no longer within the lumen of the femoral artery.
The user will know when the sealing element is no longer within the lumen of the femoral artery because the blood flow out of the proximal port or proximal end of a groove will cease or substantially diminish once the sealing element is outside of the lumen of the femoral artery and is substantially sealing the puncture wound. In this preferred embodiment, the sealing element is fabricated from an expandable material which then expands to assure an effective closure of the puncture wound.
The foregoing description has been directed to sealing a puncture wound in the femoral artery, but it is to be understood that the device of the present invention can be used to locate the lumens of other blood vessels and to seal puncture wounds in them. With that understanding, we turn to a more detailed description of the invention.
As can be seen from
The elongated member 11 of device 10 has an internal lumen (not shown) which communicates with proximal port 16 and with distal port 17. The proximal port 16 is separated from distal port 17 sufficiently to permit proximal port 16 to be outside of the patient's body when distal port 17 is within the lumen of blood vessel 14. Thus, as shown in
When the device 10 is positioned as shown in
Preferably, sealing member 12 will be substantially adjacent to puncture 20 when it is detached. However, the device 10 can be used successfully when sealing member 12 is detached proximally of puncture 20 within tract 19.
Referring now to
Alternatively, in other preferred embodiments, the sealing member will be made in such a manner that it will expand spontaneously or upon removal of a restraining force. In still other embodiments, the sealing member can be expandable mechanically, hydraulically or pneumatically. In all such embodiments, it is preferred that the sealing member be fabricated from a bioabsorbable material.
The detachable connections between the sealing member 12 and the elongate member 11 may be any of a wide variety of connections. A preferred connection is illustrated in
Accordingly, the structure of
To release the plug assembly 120 from tubing 126 and pusher 127, shaft 128 is pushed towards the plug assembly 120 while restraining movement of the tubing 126. The distal portion 129 of pusher 127 is thus pushed out of the expanded end of tubing 126, allowing the tubing to recover to its original outside diameter and to pass through the opening in the proximal portion of 121 of plug assembly 120. Distal portion 129 of pusher 127 is thereby caused to move until it comes into contact with the floor of cavity 124 thereby assisting in pushing the plug off the end of the tubing 126.
In this embodiment, detachment assembly 227 is loaded into delivery sheath 235. Delivery sheath 235 is provided with one or more bleed back openings 231 in its distal region. Bleed back opening 231 communicate with lumen 232 through which blood entering openings 231 will flow and, in this embodiment, exit through the proximal end of delivery sheath 235. As shown in
As shown in
As illustrated in
The use of the embodiment illustrated in
As shown in
As shown in
The present invention is not to be considered to be limited to the specific embodiments set forth, but is of the full scope of the appended claims.
Patent Citations
Referenced by
Legal Events
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Team Hannah
Who is Hannah? Hannah is an amazing 16 year old girl. Hannah was diagnosed with Cystic Fibrosis when she was about 18 months old. They can detect Cystic Fibrosis when the baby is in the womb. Unfortunately Hannah didn't start getting the proper treatment, or for the matter any treatment until she was adopted by the Hewitt family when she was about 3 years old. By this time Cystic Fibrosis already took its toll on Hannah, which means that she is now dealing with the repercussions of what Cystic Fibrosis can do, and how it can take over your life. Right now Hannah is in the position where her lungs can go into complete failure, and this means that she can finally be on the list for a lung transplant, but your lungs have to go into complete failure in order for this to happen. Hannah has been hospitalized 8 times in the last 12 months, and each hospital visit ranges from 7 to 10 days. These hospital visits do not include her regular visits which are seeing her specialist at least once a month to evaluate Hannah's condition. Every time Hannah goes to the hospital it's located at Kaiser which is in Oakland, Ca. Being that Hannah has these frequent visits to the hospital, her mother Beth had to stop working in order to take her to the hospital, and to care for her, so this means a less income within the house hold. It gets expensive with the hospital visits, and Hannah's treatments. Hannah shared that she takes 120 pills a week to try and keep her Cystic Fibrosis under control. There are a few fundraisers that are taking place in order to help the Hewitt family. Right now there are T-shirts being sold in order to raise funds to help Hannah and her family out. Sauced in Livermore is also willing to have fundraiser on Hannah's account on April 9th 2014. There will also be a live and silent auction present at the Sauced's fundraiser. You can also go to Team Hannah Facebook page in order to purchase a t-shirt, sweatshirt, or even wrist band.
Cystic Fibrosis is a deadly disease, and usually ends in death at a young age. The thing with Cystic Fibrosis is there is no cure at this time, but there is hope when it comes to community support. When Hannah sees people wearing team Hannah gear it literally puts a smile on her face. Team Hannah also has designated a day which is Tuesdays, and on Tuesdays we wear purple, or team Hannah gear for 'Tough Enough Tuesdays'.
Hannah came to the Hewitt family at about 3 years old with the disease Cystic Fibrosis. Beth, Hannah's mother, had noticed that all of Hannah's medications that she should have been taking for Cystic Fibrosis had been expired. Put in short terms Hannah was not getting any kind of treatment at all. Hannah had always been really sick as an infant, and her health was always challenging. There were so many hospitalizations, and appointments, and still are many. Hannah has a very common strain of Cystic Fibrosis, and this common strain continues to claim the lives that are diagnosed with this disease. The age range for Cystic Fibrosis patients is typically 27 years old. This blew me away because when I found this out I was 27 years old. It hit me like a ton of bricks. Hannah continues her treatments, but she has sustained a tremendous amount of lung damage as well as illnesses. Hannah will continue to fight for her life every day. Hannah is still attempting to live a normal life. She takes goats to the Alameda County Fair, she is home schooled, and even plans to start college courses soon. Hannah is a typical 15 year old girl who lives with Cystic Fibrosis. Hannah is not the only one out there who lives with this disease, but it is imperative that people should know about Cystic Fibrosis, and how we can all come together to help this family out. Thank you for your time. Never forget to pray for Hannah.
Dear Family & Friends,
I am happy to report that Andrew and Hannah are doing well! Thank you for your prayers and support. Tomorrow will be the last day to order Team Hannah items on the current wave so send me your requests ASAP. It is my hope to have the order by next week. Remember to wear you shirts on Tough Enough Tuesdays and post your pictures on the Team Hannah Facebook page.
The remodel is finally underway! Our footings have been completed and the framing crew for the new construction will begin in the morning. The goal for this weekend is for rough plumbing (thankfully prayers were answered for this matter), HVAC (still hoping for a contractor to offer their services) and major demolition. We are in desperate need of many volunteers. Rain will not hinder the demolition as much of that work is from the inside. If you are able to assist us please join us at 9:00 AM. No experience is necessary and there are tasks for volunteers of all capabilities. We will enjoy lunch together which will be provided.
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"The best way to find yourself is to lose yourself in the service of others." - Gandhi

subset: commoncrawl


text:
Tuscarawas News Detail
Kent State Stark Advisory Board Welcomes New MemberPosted Dec. 10, 2012
Kent State University at Stark is proud to announce a new member on the campus Advisory Board. Christopher T. White, publisher of The Repository/GateHouse Ohio Media, recently joined the 14-member board, chaired by Dick Maggiore, the president and CEO of Innis Maggiore. The Kent State Stark Advisory Board assists in the development of resources that are necessary for the campus to carry out its educational mission, among other objectives.
As a GateHouse publisher, White oversees the operation of The Repository, The Independent and The Times-Reporter, along with three weekly publications, a magazine and associated digital editions. Prior to his June 2012 appointment as publisher, he held the position of The Repository's general manager and senior vice president of sales and marketing for GateHouse. From 1993 – 2007, White was employed by Community Newspaper Holdings Inc. (CNHI), serving in various positions, including publisher, advertising director and vice president of sales and marketing.
White earned his bachelor's degree from East Central University in Oklahoma, where he was a member of the Presidential Leadership Class. As an active member of the local community, White serves on the board of directors for the Canton Regional Chamber of Commerce and Pathway Caring for Children, as well as volunteers in other area organizations.
For more information about Kent State Stark's Advisory Board, visit www.stark.kent.edu/about/offices/administration/advisory-board.cfm.


text:
An oral hygiene product especially for inhibiting caries is the form of toothpaste or mouthwash. The product maintains a low fluoride ion concentration in the mouth for longer periods than conventional products by the rapid precipitation of calcium fluoride either in the mouth or immediately prior to use. The product comprises a composition containing calcium ions and a further composition containing fluoride ions. The ion product of the calcium and fluoride ions of the combined product preferably exceeds 3×10-8 mol3 dm-9.
1. A method of inhibiting dental caries which comprises the steps of:
admixing a first composition containing a source of calcium ions from calcium chloride and a second composition containing a source of fluoride ions from sodium fluoride thereby forming an oral preparation of calcium fluoride; and
introducing said oral preparation into a mouth, said admixing step occurring outside the dentulous mouth but less than 1.5 hours prior to said introduction into the mouth.
2. The method as claimed in claim 1 wherein the ion product (IP) of the calcium ions and fluoride ions as hereinbefore defined exceeds 3×10-8 mol3 dm-9 on mixing.
3. The method as claimed in claim 1 wherein the calcium salt is calcium chloride.
4. The method as claimed in claim 1 wherein the fluoride salt is sodium fluoride.
5. The method as claimed in claim 1 wherein the compositions are in the form of a two-part mouthwash.
6. The method as claimed in claim 1 wherein the compositions are in the form of a two-part toothpaste.
This application is a continuation of Ser. No. 07/267,582, filed Nov. 11, 1988, now abandoned, which is a continuation of Ser. No. 07/102,213, filed Sep. 29, 1987, now abandoned.
This invention relates to oral products, more particularly oral hygiene products which are effective to combat dental caries.
It is well known to include water-soluble fluorine-containing salts, for example sodium fluoride or sodium monofluorophosphate, in oral products, especially mouthwashes and toothpastes, and that by regular use of such products the incidence of dental caries can be reduced. It is believed that the fluoride ion or monofluorophosphate ion, interacts with the tooth substance to increase its resistance to acid attack and to aid repair of carious enamel. However, the opportunity for this efficacious interaction to occur is short-lived because the oral fluoride level falls off rapidly after use of a mouthwash or toothpaste.
There have been attempts in the past to provide means for maintaining a certain concentration of fluoride ions in the mouth over a longer period. These have included proposals for locating a fluoride ion source in the mouth, for example as part of an orthodontic appliance.
The Applicants have investigated the possibility of depositing particles of a fluoride ion-releasing material in the mouth and have discovered that surprising results are achieved through the use of particles of freshly precipitated calcium fluoride, as is more particularly described hereinafter.
It is already known to treat teeth to provide anticaries protection with compositions containing calcium ions and fluoride ions. Such compositions are described in EP-A-89 136 (Procter & Gamble) and they comprise a calcium ion source, a fluoride ion source and a calcium sequestering agent possessing specific solubility and binding properties to control the precipitation of calcium fluoride. The calcium-sequestering agent present in these compositions has a stability constant sufficient to inhibit uncontrolled and rapid precipitation of calcium fluoride.
In U.S. application Ser. No. 4,080,440 (DiGuilo et al) there is described a two-part product for example mouthwash or toothpaste, for remineralising demineralised tooth enamel, consisting of a first solution containing calcium ions and a second solution containing phosphate ions and optionally fluoride ions, which solutions when mixed together form a metastable solution having a pH of about 4 or below. The metastable solution is applied to the tooth surface within 5 minutes of its formation. The ions diffuse into the demineralised subsurface where due to a rise in pH calcium phosphate and calcium fluoride are precipitated.
GB-A-1 452 125 (Procter & Gamble) also describes a two-part oral treatment product comprising a first solution containing calcium ions and a second solution containing phosphate ions and fluoride ions, the solutions being applied to the tooth surface sequentially. The respective ions diffuse to the subsurface dental enamel, the ions of the second applied solution coming into contact with those previously deposited and forming a precipitate which is bound to the tooth structure.
There have also been described in the literature various compositions containing both a calcium compound and a fluoride compound and wherein means are provided to inhibit the formation of calcium fluoride; examples are EP-A-40 738 (Richardson-Vicks), GB-A-777 556 (Colgate-Palmolive) and U.S. application Ser. No. 4,098,435 (Weyn).
GB 1 090 340 (Warner Lambert) discloses a one-part oral composition containing calcium and fluoride ions. Any calcium fluoride in such compositions will not be freshly precipitated.
GB 1 408 922 (Blendax) and U.S. Pat. No. 4 108 980 (Colgate) disclose compositions comprising calcium, phosphate and fluoride ions for remineralising dental enamel. The disclosed compositions contain such high levels of phosphate that preferential precipitation of solid calcium phosphate phases such as octacalcium phosphate and hydroxyapatite would deplete the liquid phase composition of calcium ions rather than allow calcium fluoride precipitation. Further, any calcium fluoride precipitation would occur slowly due to the presence of large amounts of the crystal growth inhibitor, phosphate.
The present invention provides an oral preparation for inhibiting caries, which comprises as a combined preparation a first composition and a second composition for admixing in the mouth or for admixing immediately prior to introduction into the mouth, wherein
the first composition comprises an aqueous solution containing calcium ions,
the second composition comprises an aqueous solution containing fluoride ions,
the first and second compositions being such that when mixed rapid precipitation of calcium fluoride occurs.
For optimum retention of fluoride in the mouth the ratio of calcium ions to fluoride ions should be stoichiometric (i.e. 1:2).
Rapid precipitation of calcium fluoride is induced by using high concentrations of calcium ions and fluoride ions. Thus, the initial ion product (IP) on mixing the two compositions which is given by the equation:
(Ca2+)=calcium ion concentration, and
(F-)=fluoride ion concentration
should exceed the solubility product of calcium fluoride, 2.85×10-11 mol3 dm-9 at 25° C., by at least 1000 times. More preferably, the above ion product should exceed 3×10-7 mol3 dm-9.
Rapid precipitation of calcium fluoride is not favoured by low concentrations of calcium ions and fluoride ions. At low concentrations of the aforementioned ions a metastable solution may be formed so that precipitation proceeds slowly for many minutes after the ions are mixed. Rapid precipitation is also inhibited by crystal growth inhibitors such as hydrogen phosphate ions (HPO4 2-).
The presence of substances which react with either calcium ions or fluoride ions to produce material having a solubility less than that of calcium fluoride are not advantageous. The presence of substances which reduce the amount of free calcium or fluoride ions before the compositions are mixed are also not advantageous. Examples of such materials are metal ion sequestrants such as EDTA, which react with calcium ions to form complexes, and alumina abrasive particles which bind fluoride.
In preferred embodiments of the invention the composition is in the form of a two-part toothpaste or a two-part mouthwash.
Calcium chloride is used in a preferred embodiment of the invention. Preferably a calcium ion concentration of at least 3.95 mM is used, more preferably at least 8 mM. Calcium ion levels in excess of 0.3 M provide no additional benefit and would generally not be used.
Sodium fluoride is used in a preferred embodiment of the invention. A fluoride ion concentration of at least 7.9 mM is preferably used, more preferably at least 16 mM. Fluoride ions are preferably less than 0.3 M.
One or both of the compositions may contain adjuvants. Such adjuvants may include colouring agents, flavours, humectants, abrasives, detergents, preferably nonionic detergents, and the like and other therapeutic agents compatible with calcium or fluoride ions.
In use the first and second compositions are admixed in the mouth or immediately prior to introduction into the mouth. A delivery system providing for physical separation of the two compositions and for simultaneous or sequential delivery of the compositions may also be used.
The efficacy of the freshly precipitated calcium fluoride in maintaining fluoride ion levels in the mouth is demonstrated by the following experiments.
The procedure employed for each test was as follows:
(i) a 2ml mouthwash was held in the mouth for one minute and then expectorated. Such mouthwashes consisted of two 1 ml solutions, which were either applied separately or mixed before application.
(ii) saliva samples were collected at regular intervals for several hours after mouthwash application.
(iii) Saliva samples were buffered to pH 5 by adding 10% by weight of TISAB buffer and then fluoride activities were measured using a fluoride ion specific electrode (Orion 94-O9).
The following aqueous solutions were used:
(a) 0.0526 M sodium chloride
(b) 0.0526 M calcium chloride and 0.1053 M sodium fluoride mixed immediately prior to application
(c) as (b) but mixed 1.5 hours before application.
(d) a suspension of the equivalent concentration of calcium fluoride to that of (c) diluted from a concentrated stock prepared 3 months before application. (Aged calcium fluoride).
FIG. 1 shows that salivary fluoride levels resulting from application of mouthwashes containing freshly precipitated calcium fluoride are significantly higher than the corresponding values for aged precipitates. The mouthwash containing the most aged calcium fluoride particles (three months old) gave salivary fluoride values only slightly greater than the `baseline` values measured after application of sodium chloride solution.
The following experiment was performed to demonstrate that a mouthwash containing freshly precipitated calcium fluoride is capable of maintaining fluoride in the mouth at a higher level than a sodium fluoride mouthwash of the same fluoride content.
The experiment was carried out in a similar manner to that described above using the following aqueous solutions;
(i) 0.0526 M calcium chloride and 0.1052 M sodium fluoride mixed immediately prior to application
(ii) 0.0526 M sodium fluoride.
FIG. 2 shows that salivary fluoride levels resulting from the application of mouthwashes containing freshly precipitated calcium fluoride are significantly higher than the corresponding values for sodium fluoride.
The invention is illustrated by reference to the following examples. All percentages are by weight.
______________________________________Mouthwash %______________________________________First compositionSodium fluoride 0.11Sorbitol syrup (70% solution) 15.0Ethanol 10.0Nonionic detergent 0.4Saccharin 0.04Flavour 0.15Water to 100Second compositionCalcium chloride dihydrate 0.195Sorbitol syrup (70% solution) 15.0Ethanol 10.0Nonionic detergent 0.4Saccharin 0.04Flavour 0.15Water to 100______________________________________
Approximately 5 ml of each component are mixed together immediately before use.
______________________________________Toothpaste %______________________________________First compositionSodium fluoride 0.44Abrasive silica 14.0Thickening silica 8.0Sorbitol syrup (70% solution) 50.0Sodium carboxymethylcellulose 0.65Nonionic detergent 1.5Flavour 1.0Saccharin 0.1Titanium dioxide 1.0Water to 100adjust pH to 7.0-7.5 with NaOH.Second compositionCalcium chloride dihydrate 0.78Abrasive silica 14.0Thickening silica 8.0Sorbitol syrup (70% solution) 50.0SCMC 0.65Nonionic detergent 1.5Flavour 1.0Saccharin 0.1Titanium dioxide 1.0Water to 100adjust pH to 7.0-7.5 with NaOH.______________________________________
to be mixed in equal proportions in use.
Toothpaste-mouthwash combinations are also within the scope of the invention. One such combination can be achieved by applying the first composition, 1 ml of a mouthwash of composition
______________________________________ %______________________________________Sodium fluoride 0.44Sorbitol syrup (70% solution) 15.0Ethanol 10.0Nonionic detergent 0.4Saccharin 0.04Flavour 0.15Water to 100.0______________________________________
and then immediately brushing with the second composition of Example 2.
The oral product of the invention may also be incorporated in other oral preparations or formulations such as dual composition lozenges, sweets and chewing gum.
Patent Citations
Referenced by
Legal Events
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text:
Jun 29, 2006
Hi Ladies (and gent). It's another round of Girl's Night In. Just in case y'all dont know the drill, thought I'd fill y'all in…
What time? 7pm Pacific (that's 10PM Eastern and 9PM centeral) *sorry Atlanta folks. It *is* late there.
How? Sign in to Yahoo messenger. Then click on this to IM me and let me know your Yahoo IM name. I?ll invite you in to the partay. yup. It's that easy.
*I'm here. Ignore the offline thing.
Sorry if the offline thing threw some of you off. I don't know why it wasn't showing up as online. Hrm. I'll have to fix that before the next meeting.
We had a lovely time! Sorry to anyone who didn't get to make it tongiht. Don't fret! We have another meeting on the last Thursday of the month: July 27th! You'll just need a Yahoo IM screen name and Yahoo Messenger.
THanks to everyone who was able to attend! Topics included, but were not limited to: handbags, penises, shoes, babysitters, weddings, colors, conception and much more. Special shout out to (in no particular order):
Rbelle of Bellechats
Nicole of Sitting Still
Raybelle of Not So Southern Belle
Bree of Buhtafly Wings
Sonia of The Pursuit Of Happines
Marjorie of mmpoff
Charla of Southern Mom
Traci of JellyBelly
Melissa of Space and Time
Oma of Oma's Place
Canadian Sadie of My Big Fat Mess
Jamie of Blonde Mom Blog
Mari of Mommy-Brain.
Denise of Dees Den
*If I forgot you PLEASE let me know.
**IF you couldn't make it, please try next time! I"m so sorry if you missed out. We'll do it again and you're MORE than invited. Consider it a summons.
***Could someone pelase pass the caffeine? I have to go to work tomorrow. Yes, work. ANd you thought this was summer vacation. PSHAW!
Maybe I will actually get my shit together and be there on time. Maybe.
By Sitting Still on 2006 06 29
umm..did I get stood up? I see you're not online and I'm clueless how to connect with anyone else (used to MSN Messenger.)
Sincerely, On-time wallflower
By Amy_M on 2006 06 29
No, I'm here I'm here!!!
I don't know WHY it said I'm not… damnit!
By Mrs. Flinger on 2006 06 29
WHERE is the trackback! I am posting about this and I see NO Trackback!
So here:
trackback: http://www.bellechats.com
By RB on 2006 06 29
Thanks for the good time lady's. I love talking about penis's and handbags. And no I won't say my preference!!!!
By dizzymizzy on 2006 06 29
It was FUN! What a great turnout. Yeah.
By Jamie on 2006 06 30
YAY! what fun chatting it up! gotta get one of those mics though. (I think I've said that before, lol)
By Charla on 2006 06 30
The chat last night was fun! Ya'll are a blast!!!
By Marjorie on 2006 06 30
oh great. i missed it! GAHHHHHHHHHH.
By texasbelle on 2006 06 30
It was fun, I'll be back again and will stay longer next time! I left before penises came up (no pun intended), damn!
By Sonia on 2006 06 30


text:
For the second time, a hearing regarding possible sanctions against a Palatine restaurant where authorities say illegal drug sales have taken place has been postponed. La Presa, 319 S. Rohlwing Road, could face fines or have its business license revoked or suspended as a result of the allegations, as well as claims that employees who serve liquor don't have the proper certification. Village attorney Patrick Brankin and Paul Augustyn, an attorney for Tacos Y Mariscos La Presa Inc., requested the continuance Friday with the hope of reaching an agreement. The new hearing will take place at 2 p.m. Wednesday, Feb. 13, at village hall, 200 E. Wood St., Palatine.
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Gear Review
Christopher Christopherson
Great piece, have brought this one on many ascents over the years, holds up well and is fairly lightweight. Very nice grip in cane mode. There are lighter and more technical options out there, but for an all around mountaineering axe it's hard to go wrong with this one.
View More Details on Black Diamond Raven Ice Axe


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he should be suspended...that was such a buttheaded thing to do....what was worse the break before, DWEST jogged to get back and let a guy run past him for a layup. DWEST needs an attitude adjustment and stop being such a lazy crybaby.


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Letter: Help stop the violence
To the Editor:
To update our community on gun violence, we have been surrounded by violence of guns. Kittrell had two brothers who shot their father. There was Townsville and Williamsboro, where family violence occurred, and several cases in Henderson where friends shot friends.
Be aware of mentally disturbed people and notify properly trained people. One ounce of prevention could protect a lot of people from being destroyed.
I was involved at a school in Newark, N.J., where a "most wanted" criminal had a child at the school. The FBI took charge of the incident. No one was injured or hurt.
Please notify proper authorities if someone in your community is acting strange or beyond cause. Notify the police.
Recently, I witnessed L.B. Yancey School going through a good fire drill. This school is getting prepared.
All of us need to be prepared.
Elijah Nicholson


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Franchise Encyclopedia ▪ 1998-99 Denver Nuggets ▪ 2000-01 Denver Nuggets
Record: 35-47, Finished 5th in NBA Midwest Division (Schedule and Results)
Coach: Dan Issel (35-47)
PTS/G: 99.0 (11th of 29) ▪ Opp PTS/G: 101.1 (24th of 29)
SRS: -1.76 (22nd of 29) ▪ Pace: 94.7 (7th of 29)
Off Rtg: 103.5 (19th of 29) ▪ Def Rtg: 105.8 (20th of 29)
Expected W-L: 35-47 (22nd of 29)
Arena: Pepsi Center ▪ Attendance: 637,698 (18th of 29)
Sponsor this page for $10 and help Basketball-Reference.com provide this service. Your message will replace this ad.
Transactions listed are from July 1, 1999 to June
30, 2000.
Click on the Team for team roster and stats.
Click on the Player for career stats and accomplishments.
August 3, 1999
Traded Danny Fortson, Eric Washington, Eric Williams and a 2001 1st round draft pick (Kedrick Brown was later selected) to the Boston Celtics for Popeye Jones, Ron Mercer and Dwayne Schintzius.
Signed George McCloud as a free agent.
August 6, 1999
Released Carl Herrera.
Released Loren Meyer.
Released Kelly McCarty.
September 2, 1999
Signed Shawnelle Scott as a free agent.
October 1, 1999
Signed Roy Rogers as a free agent.
October 26, 1999
Waived Shawnelle Scott.
February 1, 2000
Traded Chauncey Billups, Ron Mercer and Johnny Taylor to the Orlando Magic for Tariq Abdul-Wahad, Chris Gatling and a future 1st round draft pick. Denver accepted Omar Cook from Orlando on June 26, 2001 in lieu of the future 1st round draft pick.
June 23, 2000
Traded a 2001 1st round draft pick (Joseph Forte was later selected) to the Utah Jazz for a 2000 1st round draft pick (Mamadou N'Diaye was later selected).
June 27, 2000
Traded Chris Gatling and a 2000 2nd round draft pick (Eddie House was later selected) to the Miami Heat for Voshon Lenard and Mark Strickland.
June 28, 2000
Drafted Mamadou N'Diaye in the 1st round (26th pick) of the 2000 NBA Draft.
Drafted Dan McClintock in the 2nd round (53rd pick) of the 2000 NBA Draft.


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During Apple's next-generation Mac Pro portion of its iPad event earlier today, the company took some time to present first impressions from a few professionals that have been using the machine. While the public won't officially get its hands on it until December, Apple noted that three professionals had been testing the new Mac Pro. One of those pros was award-winning extreme sports photographer Lucas Gilman pictured above next to his Mac Pro setup with a 4K Sharp display. We thought it would be interesting to have a chat with one of the only people in the world currently using the new Mac Pro, so we've reached out to Gilman to get his first impressions and learn more about his experience with Apple's completely redesigned professional Mac line.
Head below for the full interview.
Hi Mr. Gilman. Thanks for taking time to answer a few questions.
Q: Can you talk a little about how you've been using the new Mac Pro and your first impressions? How has your hardware setup/workflow changed due to the performance of the new machine?
A: I was really surprised at how small the form factor was and I really liked the solid feel and finish of the unit.
I used Mac Pro and Aperture primarily to import and process Nikon D800 Files which are about 75+ megabytes each and are 230+ megabytes once exported as 16 bit TIFFS. I download images in the field to the G-TECH G-Dock and EV drives. The Mac Pro I was using had a one Terabyte SSD so I relied on external G-TECH Thunderbolt drives to store the images in the studio. I use two G-TECH G-SPEED Q's with USB 3. One to store my raw archive and one to store finished TIFF files. My working driving is a G-drive Pro with Thunderbolt, which I like because I'm getting speeds of around 480 megabytes/second which is great for the stills and video I shoot.
Q: Were you using a previous generation Mac Pro before moving to the new Mac Pro? What advantages does the new Mac Pro have over your old setup?
A: I was using the fastest fully loaded 27inch iMac with Fusion drive and 36 GB's of ram. The advantages of the new Mac Pro for me are 4k display support, blazing fast speeds and unmatched processing power allowing me to get back in the field and continue to produce content quicker than ever before. I travel 200+ days a year and the less time I can spend in the office and the more time I can spend in the field the better my bottom line is. Or, maybe I even get to spend a little extra time with my family!
Q: Is Thunderbolt a noticeable step up in performance vs your old setup? We're you using Thunderbolt 1.0 in your workflow previously?
A: I'll be excited when Thunderbolt 2 drives hit the streets, but I was really happy with the G -Drive Pro with Thunderbolt and the speeds of around 480 megabytes a second – The transfers, exports and workflow were smooth and seamless.
I didn't do any benchmarks regarding internal vs external storage save/open times and put it through the paces as I would in my everyday workflow, but everything seemed noticeably faster than any computer I've ever been on before.
Q: Have you taken advantage of the Mac Pro's 4k display support?
A: I got to try the Mac Pro unit with a Sharp 4K display and it was amazing at the amount of depth and clarity I could see in my 36.2 megapixel Nikon D800 images.
Q: How has your workflow improved with the new Mac Pro using the latest version of Aperture? Has the new support for iCloud Photo Sharing in Aperture 3.5 come into play?
A: The new 3.5 version of Aperture and Mac Pro seem to be really tuned to work together. It was a noticeable improvement on speeds and allowed me to really plow through a LOT of content in a really short amount of time – Really cutting the import and export time down as well as streaming though and editing tons of images. I'm excited about the SmugMug integration for building galleries for clients and selling prints online.
Q: How long have you been using the new Mac Pro and when did Apple approach you to test the new machine?
A: I got to test drive the new Mac Pro about a week ago.
Q: Are there any applications that were pain points before that were fixed with the new Mac Pro and Thunderbolt?
A: I shoot video as well as still images and the multicore processors and dual graphics cards really supercharged my Final Cut X experience – I'm excited to try it out on a new project.
Q: Do you ever find the need to use a PCI card but can't?
A: There are so many Thunderbolt accessories and chassis in the works these days I think that you'll be able to find an external box for whatever card you need very soon.
Q: Lastly, what was the most surprising aspect of your experience with the new Mac Pro?
A: I was really surprised that so much power could come in such a small package – it really boggles the mind.
Apple's new Mac Pro features an all-new cylinder design, completely new internals, and will be assembled in the USA when it officially begins shipping sometime in December. The base model with a 3.7GHz quad-core Xeon processor, 12GB of DRAM, Dual FirePro D300 graphics and a 256GB 22D starts at $2999 and Apple will also have a $3999 configuration and a number of built-to-order options. Full details on specs for the new Mac Pro are here.
Gilman added that he thinks "Apple really hit a home run with the performance on the new Mac Pro."
Leave a Reply
30 Responses to "Interview with photographer Lucas Gilman, one of the only pros already using Apple's next-gen Mac Pro"
I have a Nikon D800E and an iMac 27. Maybe i should upgrade my setup soon :-)
Man, Apple really does put words into his mouth.
Everything about the "New" Mac Pro is forward-thinking except the HDMI port, it is 1.4 instead of 2.0, so that means no 4k@60fps. I think I am going to wait for the next revision.
Supposedly HDMI 1.4 can be upgraded to 2.0 via a firmware update. This has already been pre-announced on some video cameras.
Yeah right having 10 external boxes on the table instead of one computer……
So he was using an iMac perfectly fine before and he only works with photographs. That means he isn't taking advantage of either of the "professional" GPUs in his Mac Pro, more than half of the computer's value.
What he really needs is a Mac Mini with PCIe SSD and support for one 4K display, the Mac Mini Pro apple let him test is FAR overpowered and overpriced for what he needs.
My 2008 aluminium macbook can handle the 37mp 16-bit raw files from my medium format camera while I am in the field. Photography isn't exactly the most demanding task. Can't complain about the 4k display though! I'd buy it for that.
3 grand for a single cpu workstation with no PCIe slots, and no possibility to add a second CPU…
Why isn't Apple coming out with their own 4K display though?
I agree with Lance. Although he looks to be a good photographer I would not take his advice on computer hardware to run a multi-discipline design studio. His site is still a Flash based templet. We do extensive image editing of Photoshop files between 300 and 800 megs on a regular basis using a G5 Xeon based 'cheese grader" without and slowdown. But that means any one of these files are larger than the SSD that comes with the base computer.
What is a "cheese grader"? Is that kind of like a cheese grater but with a rating system built in?
"We do extensive image editing of Photoshop files between 300 and 800 megs….But that means any one of these files are larger than the SSD that comes with the base computer"
Wow the base SSD is less than 800 megabytes!?
Site is not flash it's html. I would not take your advice on programming languages, you seem to have no clue.
That is supposed to make his site better?
what monitor does that guy have in the picture?
The part of this whole announcement that makes me sad is the fact that Aperture doesn't appear to be getting a major upgrade. :.(
I won't be able to afford a Mac Pro, but I could afford an upgrade to Aperture.
Allow me to go on a very brief rant. With Adobe frustrating their customer base with expensive subscription-based software, Apple is in a great position to woo photographers with well-priced pro-grade apps.
They gave Aperture a bump yesterday, but no overhaul. I'm certified in Aperture and even with that I never use it anymore. Maybe it runs better on a new Mac Pro….
I wonder what size display he is pictured with, to compare it against the Mac Pro!
Wow, this feels so loaded with PR. The credibility of this site goes down when I read this. Normal people don't talk like that.
The 27″ iMac supports 32GB of RAM, not 36GB as mentioned above.. Was it a typo or a glitch in a fiction story?


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The Central Arkansas Library System awarded Christ the honor for his nonfiction work "Civil War Arkansas 1863."
The Worthen Prize is awarded each year to an author living in the CALS's service area whose work is highly regarded. It is named for Booker Worthen, who served 22 years on CALS's board of trustees.
Christ will receive the prize at CALS's annual event, "A Prized Evening," held in October.
Christ, community outreach director for the Arkansas Historic Preservation Program, has edited a number of books and articles about Civil War events in Arkansas.
He recently received the 2013 State Preservation Leadership Award from the Civil War Trust, the largest nonprofit battlefield preservation organization in the United States.
He is a member of the Arkansas Civil War Sesquicentennial Commission, serves as chairman of the board of directors of the Arkansas Humanities Council, and is a member of the board of trustees of the Arkansas Historical Association.
Christ holds a bachelor's degree in journalism from UALR.


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July 30, 2015
Barbeque enthusiasts from all over Texas fired up the grill Saturday, at the Brazos County Expo Complex. Thirty nine teams competed in the 20th annual Brazos County Go Texan Cook-off.
Ribs were slow-cooked all day long to get the flavor just right, but cooks stayed tight lipped about the recipes.
The cook-off raised money for local Go Texan scholarships.
Last year, Brazos County Go Texan gave away $135,000 in scholarships to local graduates.
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We'd like to encourage customers to brew any of our coffees using any brewing method!
If you're specifically looking for coffees originally created for espresso brewing, you'll find those listed as Year-Round products. And, again, we'd definitely encourage you to consider any coffee we offer appropriate for any brewer.
Slow Motion / Decaf – 12 oz bagWe pay extra attention to decaf because we know people love it solely for its flavor. For Slow Motion, we start with great coffee—from the same farmers we work with for all of our coffees—and decaffeinate it in small batches using chemical-free water processing. Learn more$15.75
Sipacapa – 12 oz BagThe small cooperative that produces this coffee is in San Marcos—a region of western Guatemala that is very high in elevation and has a notably dry climate. Only in the last few decades have people there really been planting and increasingly focusing on coffee. This is our third year working with this organic producer group, and we love the notes of dark chocolate, grape, and brown sugar this coffee delivers. Learn more$15.75
Line Drawing – 12 oz boxLimited-Release
With our limited-release blends, we merge our best, most-forward-thinking concepts with our best coffees to create something that resonates on a different level. Line Drawing is about re-thinking how we work sustainably in the world—focusing particularly on the Colombian and Kenyan coffees in this blend. So, enjoy the simplicity of this outstanding coffee—with notes of cranberry, grapefruit, and molasses—and find out more about what we are doing by reading the story of this coffee. Learn more$15.75
La Voz – 12 oz BagThe farms of growers contributing coffee to the La Voz cooperative are nestled among the volcanoes surrounding the breathtaking Lake Atitlán—easily one of the most beautiful places in the world. For a second year in a row, the well-managed co-op produced a coffee with notes of crisp red apple and light fruit tones complemented by a sweet, nutty finish.Learn more$15.75
Kinyari – 12 oz BagThe Kinyari coffee farm in the Embu region of Kenya was originally planted in the mid-1970s. Stephen Ruita Munyi has owned and managed the farm for decades now. He has expanded the small plots of land that make up Kinyari and implemented a well-organized and impressive mini-washing station on-site. This is our second year offering this coffee, and we love the bright notes of golden raisin, nectarine, and green apple. Learn more$18.00
Idido - 12 oz bagThis first lot from the Idido cooperative in Yirgacheffe, Ethiopia, represents a select group of 200 of the most dedicated farmers in the co-op. These farmers turn in their best cherries at the peak of harvest for this washed, special preparation coffee. Look for floral, melon, and citrus notes. Learn more$18.00
Hologram – 12 oz bagHologram is our update of the classic Mocha Java flavor profile. Fruit-forward and chocolatey coffees combine to create something distinctly complex. Learn more$15.25
Haru - 12 oz bagDowntown Yirgacheffe sits in a small valley. Up at almost the peaks on either side are the communities and cooperatives of Idido and Haru. We have been buying coffee from both of these places for years, and, even though geographically they're close, they have distinct and impressive profiles. This lot was produced exclusively for us by the Haru cooperative and is distinctly tea-like—brimming with elegant floral notes and lemongrass. Learn more
Forty-Six – 12 oz bagReclaiming dark roasts from the realm of less-than-great coffee, we take some of our best and roast them with care in Forty-Six to create something complex, sweet, clean, smoky, and nuanced. This coffee was originally recipe #46; hence the name. Learn more$15.25
Finca El Puente - 12 oz bagFinca El Puente is a special coffee that is truly close to our hearts. We encountered it on our very first trip to Honduras, fell in love with it then, and have been head over heels ever since. Moisés Herrera and Marysabel Caballero—the couple who run the farm—have become like family, and this year they continued the tradition of refining an already-great coffee. This harvest of Finca El Puente brings plum notes and brown sugar sweetness with toasted nut in the finish. Learn more$16.50


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Manage your
financial life. Real time.
Any time.
Looking to buy a car?
Find out the fair market value at NADA guides. Click here, or on the image to the left.
Holiday Closings
MidValley FCU will be closed for the following holidays during 2014:
- January 20th - Martin Luther King Day
- February 17th - Presidents Day
- May 26th - Memorial Day
- July 4th - Fourth of July Celebration
- July 24th - Pioneer Days
- September 1st - Labor Day
- October 13th - Columbus Day
- November 11th - Veterans Day
- November 27nd - Thanksgiving Day
- December 25th - Christmas Day


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SwordMark is British Fencing's Club Accreditation Programme which shows that clubs have demonstrated a minimum level of operating standards in working with young people and offer a safe and supportive club environment.
SwordMark is based on Sport England's Clubmark Accreditation Programme and includes all their Clubmark criteria.
Blackheath Fencing Club is implementing these standards and hopes to achieve accreditation in the next few months.
You can read more about SwordMark on the British Fencing website
As parents or carers you do need to be aware of some of the SwordMark policies so we have put them together in a Parents Pack for you to download. It contains six documents but they are in print this size and only the Welcome Letter goes into a second page.These are:
- Welcome letter
- Child Protection policy (short version!)
- Code of Practice for parents and carers
- Code of Practice (ie rules) for junior members (please discuss these with your child)
- The anti-bullying policy and
- Equity Policy statement
When you register for membership you will be stating that you have read these!
If your Musketeer has started fencing there is a British Fencing Parents Group that provides support and advice.
We are a non-profit organisation run by volunteers. There are many small (and not so small) things you can do to help so become a volunteer and help bring this exciting sport to youngsters. You can find out more about that on the Volunteer page.


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"You were taught, with regard to your former way of life, to put off your old self...to be made new in the attitude of your minds; and to put on the new self, created to be like God in true righteousness and holiness." Ephesians 4:22-24
Thanks for posting that, Brenda - what a great blog! :)
I don't get to talk to a lot of actual grown-ups during the day, so your comments make me really happy! :)


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Creating a successful newsletter means spending less time on repetitive tasks and more time creating the design. In Designing a Newsletter, graphic designer and Adobe Certified Instructor Nigel French teaches effective design and production techniques. He uses Adobe InDesign, Illustrator, Photoshop, and Bridge to create an eight-page newsletter that's eye-catching and impactful. Nigel establishes an efficient workflow using multiple programs, examines the aesthetics of integrating text with images, and teaches best practices for outputting a final document. Exercise files accompany the course.
So you're itching to get started and I am too, but it's really going to help us if we take a moment just to set up a workspace that has all of the palettes, or panels as they're now called, that we need for the kind of work that we're going to be doing. So I'm going to start out with the Typography workspace, which is a good starting point, but there are some panels there that I'm frankly not going to be using and there are other panels that I need that I'm going to need to add to this workspace, then save the workspace and we've always got that to return to anytime.
So let's see, Gradient. We're not going to be using Gradient too much. So I'm just going to pull that one out and close it. If we need it, I can always go get it again from under the Window menu. Hyperlinks, don't need it. Paragraph, don't need it, and I don't need it because all the options on the Paragraph panel are available on the control panel up here. So I might as well save space by not having that one. And Character, don't need that one either for the same reason. All of the options that are on the Character panel are available on the control panel.
But in addition to these, there are some that we don't have that would be worth us getting. Info, nice to have that around, handy for word counts and also to check the resolution of images. So how about we drag Info onto the Stroke group. Let's see, what else? Object and Layout, nice to have the Align panel. I think we'll put that in that group right there. Don't need the Pathfinder and then Object Styles, which I'll group with Paragraph Styles and then I'll also put Character Styles in the same group. That looks good.
I'm now going to come up to the Window menu > Workspace > New Workspace. I'm going to give it my name. Click OK. So now at any time throughout the course of our working session. Things are going to get messed up as they inevitably do, but I can reset to that working space at any time.
There are currently no FAQs about Designing a Newsletter.
Access exercise files from a button right under the course name.
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Titanium Rain 2 (Hardcover)
|Author: Josh (CON)/ Rocha Finney
|Illustrator: Josh Finney Kat Rocha
Learn more about Titanium Rain 2:
Format: Hardcover
Publisher: Diamond Comic Distributors
Sku: 215655877
Publish Date: 4/27/2011
Pages: 196
See more in Science Fiction
|The Sino Conflict heats up as the Jade Army continues its relentless advance across China. The Union is desperate, the Allies can barely hold their ground, and looming on the horizon is the specter of all-out nuclear war. Caught in the middle of this maelstrom are the men and women of Phoenix Squadron, a group of US Air Force fighter pilots who have sacrificed some of their humanity for the advantages of cybernetic enhancement. In this second installment of the Titanium Rain trilogy, the war gets bloodier, the stakes get higher, and secrets are revealed about the true nature of the Prometheus Initiative. Like the war itself, will Prometheus lead mankind ever closer to ultimate destruction? Or is it the dawning of a new age?


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+385 20 440 100
+385 20 440 100
International PHONE NUMBERS
All calls will be charged at the local rate
Need help?
Australia (Sydney) +61-28-0730571
Austria (Vienna) +43-1-3649207
Canada (Montreal) +1-438-7920109
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Dubrovnik HR
Ston & Korcula
Discover a charming little town of Ston with its 5-kilometer long walls; and the island of Korcula - the hometown of Marco Polo, the famous world traveler.
On this excursion you will:
WHAT'S INCLUDED? Transfers, guide, entrance to the cathedral, oysters, wine and cheese tasting.
Price: 65,00 €
Children (2-12y): 50% discount
Infants: Free
- Make your first stop in Ston, a town renowned for its delicious oysters, that you will taste in one of the local restaurants, accompanied by a glass of local wine.
- Continue with a drive to Orebić where you will take a ferry to Korcula. Covered with dense pine forest, the island was named Korkyra Melaina, meaning "Black Korcula", by the Greeks in the 3rd century B.C. The city of Korcula is one of the most beautiful medieval cities on the Adriatic Coast.
- Tour its charming streets and squares with Renaissance palaces, and magnificent Cathedral of St Mark, the city's patron saint.
- Drive along the Peljesac with a stop for a visit to the local winery where we will taste some of the famous local wines and cheese.
WHAT'S INCLUDED? Transfers, guide, entrance to the cathedral, oysters, wine and cheese tasting.
Price: 65,00 €
Children (2-12y): 50% discount
Infants: Free


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Below is a list of KAP directors. For a list of KAP instructors, members of the steering committee, and Kenyon KAP faculty, consult the links to the right.
Responsibilities: Contact for registration, applications, class lists, billing, transcript requests, grades, and all other Kenyon records
Phone: 740-427-5032
Fax: 740-427-5615
Address: Kenyon College; Gambier, OH 43022
Email: firstname.lastname@example.com
Responsibilities: Contact for academic programs, school membership, KAP Convocation, new faculty appointments
Phone: 740-427-5317 or 4314
Fax: 740-427-5572
Address: O'Connor House; Kenyon College; Gambier, OH 43022
Email: email@example.com
Responsibilities: Contact for administration, KAP Website, web conferencing, publications, steering committee, general information
Phone: 216-464-1441
Fax: 216-765-7181
Address: 1 Lyman Circle; Shaker Hts, OH 44122
Email: firstname.lastname@example.com
Responsibilities: Liason with Columbus area partner KAP schools, Coordination of Summer Workshops, Coordination of KAP Summer Seminars
Phone: 740-427-5325
Fax: 740-427-5762
Address: History Department; O'Connor House, Kenyon College, Gambier, OH 43022
Email: email@example.com


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Please note: The FAQ pages at the HPCVL website are continuously being revised. Some pages might pertain to an older configuration of the system. Please let us know if you encounter problems or inaccuracies, and we will correct the entries.
All of these things are documented at http://docs.sun.com , but the mass of information on that site makes it a bit difficult to know where to look. Try using the search engine.
If you have questions that you can't resolve by checking documentation, you can Contact us. We have several user support people who can help you with code migration to the parallel environment of the HPCVL facilities. If you want to start a larger project that involves making code executable on parallel machines, they might be able to help you. Keep in mind that we support many people at any given time, so we cannot do the coding for you. But we can do our best to help you get your code ready for multi-processor machines.
Of course, some programs are inherently non-parallel, and trying to make them scalable might be too much effort to be worth it. In that case, the best one can do is try to improve the serial performance by adopting the code to modern computer architecture. The performance enhancement that can be achieved is sometimes quite amazing. It seems, however, that most programs have a good potential to be executed in parallel, and a little effort in that direction often goes a long way.


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Feb. 20, 2010
COMPTON, Calif. - A three- run seventh inning gave the Matadors the lead once against the Southern Wildcats Saturday afternoon in their second game of the Urban Youth Invitational in Compton, Calif. However a late inning Jaguar rally was enough to hand CSUN their first loss of the season as Northridge was defeated by a score of 12-9.
Unlike yesterday's game where CSUN's opponent was the first to light up the scoreboard, second baseman Ryan Pineda helped the Matadors take an early 1-0 lead when he hit a line drive home run over the left field fence on the second pitch he faced from Jaguar pitcher Jarrett Maloy.
First baseman Dominic D'Anna then hit a long single to shallow right field, before advancing to right field on a wild pitch before touching home plate six pitches later when catcher Dominic Piazza lined a single to the gap in left-centerfield.
Matador left-fielder C.J. Belanger then hit a pop fly that ended up falling in-between the Southern second baseman, centerfielder, and left-fielder that enabled Piazza to round third and slide safely just underneath the mitt of Southern catcher David Nolting for the third run of the inning.
That lead would increase moments later when Southern shortstop DeMario Ellis misplayed a ground ball hit by third baseman Jason Dabbs and rushed his throw to first base; a throw that severely missed its intended target, allowing Belanger to score the final run of the inning for Northridge.
Southern would respond with one run in the bottom of the second, and eventually piece together a six-run inning to swing the lead in their direction.
The Southern rally would have taken a serious hit midway through the inning; with Southern runners at first and third, Ott made a double-pickoff move that froze the runner at first in his tracks for what would have been the second out.
Instead, the move was ruled a balk, with Southern scoring another two runs to knock Ott out of the game.
CSUN began chipping away at the Southern lead when C.J. Belanger hit a double to left-centerfield with two out in the inning to place himself in scoring position before reaching home on Billy Swanson's first triple as a Matador to cut Southern's lead to 7-5.
The score would remain the same until the top of the seventh when Pineda led off the inning with a single, then stole his first base of the season to put himself in scoring position.
D'Anna would advance to Pineda to third on his single to centerfield before catcher Dominic Piazza drove Pineda home with his double that landed in fair territory down the line in right field to decrease the Jaguar lead to only one run.
After advancing to third on Piazza's double, D'Anna advanced another 90 feet thanks to a balk by Joshua Rochelle to tie the game.
Northridge soon regained the lead on the very next at-bat when Belanger was called out on a razor-close play by the Jaguar first baseman who fielded Belanger's bunt and won the footrace between the two, if only by a step or two.
Even though he was called out on the play, Belanger successfully enabled Piazza to sprint from third to home to score, giving CSUN an 8-7 lead.
Having originally entered the game with his team down 7-4 in the bottom of the third, Justen Gorski pitched brilliantly throughout the duration of his 3.1 innings pitched as the sophomore right-hander allowed only four hits, striking out two in the process.
The one-run CSUN advantage would double the very next inning when a centerfielder Andrew Muren hit his second career triple to drive in shortstop TS Reed who led off the inning with a single.
That lead would become short-lived, as Southern was able to string together five hits to score five runs of their own; a scoring run that would prove to be the difference in the game.
The Matadors will now travel to Westwood to face the UCLA Bruins in the third and final game of the MLB Urban Invitational. RHP Shawn Wilyman will face Bruin left-hander Rob Rasmussen, first-pitch is scheduled to take place at Jackie Robinson Stadium at 2:00 p.m. Matador fans who are unable to attend can still follow all the action online on GameTracker at www.GoMatadors.com.


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|MUD Listing
Main | Search | Show All Listings | MSSP
|Telnet Address
|crimsongate.kyndig.com [Click to Connect!]
|Website Address
|Keith Mervine
|Out of the mists, a Crimson Gate stands before you. You
have heard of such gates but have never seen one. Do you
dare enter it, and let the fates decide where you shall
end up, or do you pass this chance by to become wealthy
and powerful beyond your wildest dreams? The choice is
before you.
Once a great wizard, Thalor the Lich Lord now attempts
to rule over all. The forces of Palladia, Aretymis,
Jade and Nimloth keep him at bay. Now Palladia, Jade and
Aretymis are dead. Killed by his evil plots. New gods
have stepped up to challenge him. Others have been employed
in the fight to keep Thalor at his station, and to keep him
from ruling the world.
Crimson Gate features a tiered class system.
Cabal/clans have been replaced by a religious/faction
system. 500 spells/skills are available, along with an
artifacting system with famous artifacts such as the Deck
of Many Things, The Rod of Seven Parts and other, original
artifacts, with powers only found at Crimson Gate. Items that
gain levels like players. Role playing is encouraged but not
Stop on by!
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Aug 4, 2015, 9:50 am


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Chuck Landon Grades the Herd
Chuck Landon Grades The Herd ... Purdue 51, Marshall 41
OFFENSE: C - Yes, it produced 41 points for Marshall. But it also created 14 points for Purdue.
DEFENSE: F - It got better in the second half, but Purdue's offense also lost focus and let down after intermission.
SPECIAL TEAMS: C- - It blocked a punt and a PAT while scoring a TD, but struggled in every other phase.
COACHING: D - The defense simply isn't getting better. That must be addressed.
OVERALL: C - Yes, the Herd was competitive. But this game was winnable with better defense.
The Herald-Dispatch welcomes your comments on this article, but please be civil. Avoid profanity, obscenity, personal attacks, accusations of criminal activity, name-calling or insults to the other posters. Herald-dispatch.com does not control or monitor comments as they are posted, but if you find a comment offensive or uncivil, hover your mouse over the comment and click the X that appears in the upper right of the comment. If you do not want your comment to post to your personal Facebook page, uncheck the box below the comment.


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The non-war against the Qaddafi regime in Libya continues to languish. Feuding among the rebels that led to the killing of their military commander, Gen. Abdel Fatah Younis, has further put off the day when Moammar Qaddafi will finally have to yield power. It hardly helps that President Obama, after getting the U.S. involved in this conflict, has taken such a laid-back attitude that he seems barely to notice that we are at war at all. Nevertheless the likelihood is that Qaddafi will have to step down sooner or later, and it is important to plan for that day.
Thus it is encouraging to see the rebels' National Transitional Council drawing up plans for administering a post-Qaddafi state. The key challenge—as it was in Iraq, Afghanistan, and other states were dictatorial regimes were toppled—will be maintaining order. The rebel government will obviously have an important role to play in this task but it is doubtful that it will have sufficient resources, at least not right away. It is therefore incumbent on NATO states that have been waging war on Qaddafi to make plans to send in a stabilization force after he is gone.
The Council on Foreign Relations, where I work, has just released a valuable memo through its Center for Preventative Action by Johns Hopkins University professor Daniel Serwer that calls for "the European Union (EU) to lead an international post-Qaddafi stabilization effort, preferably under a UN umbrella, to facilitate participation by members of the Arab League and the African Union (AU)." It would be great if the EU could in fact take on this mission, although I am less optimistic that Serwer that "a paramilitary police force of up to three thousand personnel" will be sufficient to stabilize a country of 6.4 million people. I would be more comfortable with at least 50,000 peacekeepers (still well short of the 130,000 that would be necessary if one took seriously the counterinsurgency formula of one soldier or cop per 50 civilians), and I have some real doubts as to whether the EU will be able to handle the mission; NATO will undoubtedly need to get involved.
But whatever the origin and numbers of the peacekeepers, the key point is that they need to be ready to go when Qaddafi falls—and for that to happen we need to have more of a public conversation on the subject. Serwer is to be commended for helping to spark some of that discussion.


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Your patience is appreciated while our site is under construction.
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The GEET "C3 Universal" DIY Kit is designed for those who want to save time by purchasing a pre-fabricated unit designed to the specifications available on the free plans available from Paul Pantone. This unit is also designed with proprietary information available to those who are licensed by Paul Pantone to engage in research, manufacturing and sales.
The GEET "C3 Universal" DIY Reactor Kit is constructed of high Quality 304 Stainless Steel with Robotic Welds. This Kit is designed for small single cylinder engines, (1-16 HP) using gasoline as a fuel. Kit includes 3 rods to accommodate the three mounting positions, Horizontal, Diagonal and Vertical.


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Classes start Monday, Aug. 24th with shows Nov. 19-22
Register early to hold your child's spot!
Welcome!At CFPA, we believe that every child has potential to shine!
Central Florida Performing Arts (CFPA) is a non-auditioned musical theater company for kids in the Orlando area. The goal of CFPA is to provide children, ages 3 years to teens, the opportunity to grow and develop in the areas of singing, dancing, and acting while building confidence and self-esteem through performing. We are dedicated to producing quality, family-friendly musical theater at an affordable cost.
Children who participate learn about art, music, theater, and most importantly, teamwork. Our programs develop creativity and self-expression in a safe and fun atmosphere. Over the 15 years CFPA has been in the Orlando area, we have inspired hundreds of young performers to discover their own unique performing abilities while building valuable skills that extend to all facets of life.
CFPA's theater for kids is unique in that we are non-auditioned. Every student who enrolls in our program has an opportunity to perform in the show. Auditions for individual lead roles come after the semester has started and are open to anyone.
Join one of Orlando's best kept secrets for children's theater today!
In a nutshell...
- Non-Auditioned
- Every child is welcome and will be in the show!
- Affordable
- Multiple performances in a professional 118-seat theater
- Great Location with good parking
- Free Wi-fi in the lobby
- Access to a beautiful outdoor courtyard
CFPA's Star Kids sing at the It's A Small World 50th Anniversary Celebration in Walt Disney World, Florida - 4/10/14


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Looking for a Used Nitro in your area?
CarGurus has 2,399 nationwide Nitro listings starting at $4,500.
Have you driven a 2007 Dodge Nitro?
Average User Score
3.9 ⁄ 5 stars
Based on 14 reviews
2007 Dodge Nitro Overview
Overall User Score
Based on 14 reviews
The 2007 Dodge Nitro comes with a pair of engine options under the hood, a 3.7 liter V6 or a 4.0 liter V6 with 210hp and 255hp respectively. To go along with these are three transmissions, a 5 speed automatic, a 5 speed manual, and a 4 speed automatic, depending, of course, on the trim you elect. As a mid-sized SUV, gas mileage isn't great, 17/23, but it's certainly better than the massive beasts that dominated the SUV market a few years ago. This is a car that has some of the benefits of both worlds, size and economy.
There are a fair number of comforts and conveniences in the 2007 Dodge Nitro. Air conditioning, cruise control, leather seats, a CD player, a nav system, heated seats and a sun roof are all available. And with 76 cubic feet of cargo space and plenty of passenger room, there shouldn't be much that a normal person can't carry. Traction control, ABS and of course airbags keep passengers and drivers alike safe. An all new line for Dodge, the 2007 Nitro looks on paper like it should be a successful vehicle for the American car maker.
And judging by the reviews of the owners of the 2007 Dodge Nitro, I'd say that most of them would agree. People were happy with the mediocre gas mileage, and with the amount of space available. Some common criticisms were the headrests and the difficulty taller people can have getting into the driver�s seat, due to how high the seats sit. Other than that, most of the comments were very positive. The 2007 Dodge Nitro might actually be a good option for a step down from the Durango.
What's your take on the 2007 Dodge Nitro?
Dodge Nitro Questions
My A/c Stopped Working Completely. I Bought And Replaced The Resistor.noth...
Car Don't Responding To The Keys It Doesn't Start
My Car Was Blowing Cold Air Until I Over Charged It With Freon...what Could...
I tired letting sum freon out and drive around a little while starting getting cooler until I park the car.
My Dodge Nitro Won't Rev Over 2000 Rpm
2007 dodge nitro ( have had less then one month!!!) I need help the car will not rev of 2000 rpm in park or drive starts fine and runs fine other then will not go over 2000 rpm? any help would be nice