text:
Substances isolated after cultivation of a micoorganism belonging to the genus Penicillium in a culture medium comprises compounds which have strucures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesterolemic and hypolipemic medicaments.
1. The compound: ##STR6## or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
2. The pharmaceutically acceptable salts of the compound of claim 1, wherein the cation is derived from ammonia, ethylenediamine, N-methylglucamine, lysine, arginine or ornithine.
3. The ammonium salt of Compound II of claim 1.
4. The ethylenediamine salt of Compound II of claim 1.
5. The lower alkyl esters and substituted lower alkyl esters of the compound II of claim 1.
6. The ethyl ester of Compound II of claim 1.
7. An antihypercholesterolemic pharmaceutical composition comprising a pharmaceutical carrier and an effective antihypercholesterolemic amount of the compound: ##STR7## or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
8. The composition of claim 7 wherein the compound is a pharmaceutically acceptable salt wherein the cation is derived from ammonia, ethylenediamine, N-methylglucamine, lysine, arginine or ornithine.
9. The composition of claim 7 wherein the compound is the ammonium salt of Compound II.
10. The composition of claim 7 wherein the compound is the ethylenediamine salt of Compound II.
11. The composition of claim 7 wherein the compound is a lower alkyl ester or substituted lower aklyl ester of Compound II.
12. The composition of claim 7 wherein the compound is the ethyl ester of Compound II.
This is a division of application Ser. No. 207,508, filed Nov. 17, 1980, now U.S. Pat. No. 4,343,814.
This invention relates to hypocholesterolemic products from the cultivation of a microfungus of the genus, Penicillium. More specifically, it relates to compounds of formulae I and II: ##STR2## as well as pharmaceutically acceptable salts and lower alkyl and substituted alkyl esters of the carboxylic acids in which the possible substituent is phenyl, dimethylamino or acetylamino. The invention also relates to a process of cultivating the microfungus and isolating from the medium a hypocholesterolemic compound of the above structures. These new compounds have excellent properties of inhibiting cholesterol biosynthesis and are useful against hypercholesterolemia and hyperlipemia.
Because of the possible connection between high blood cholesterol and atherosclerosis, many efforts have been made to find ways and substances which would reduce the cholesterol in the mammalian body. One of these ways is to inhibit in mammals the body's ability to synthesize cholesterol.
Recently, Endo et al., described (U.S. Pat. Nos. 4,049,495 and 3,983,140) a fermentation product obtained by cultivation of a microorganism of the genus Penicillium and isolation from the medium. They called it ML 236 B and determined its structure together with two related compounds 236 A and 236 C. Its structure, under the name compactin, was also determined by A. G. Brown, T. C. Smale, T. J. King, J. Chem. Soc. (Perkin I) 1165 (1975). This compound has been found to be an inhibitor, in vivo, of the biosynthesis of cholesterol.
It has been found that the cultivation of the same microorganism employed by Endo, produces compounds I and II that are also very potent inhibitors of the biosynthesis of cholesterol in mammals.
The pharmaceutically acceptable salts of compound II, that are also part of this invention, include those formed from cations such as sodium, potassium, aluminum, calcium, lithium, magnesium, zinc, ammonia, ethylenediamine, N-methylglucamine, lysine, arginine, ornithine, choline, N,N'-dibenzylethylenediamine, chloroprocaine, diethanolamine, procaine, N-benzylphenethylamine, 1-p-chlorobenzyl-2-pyrrolidine-1'-yl-methylbenzimidazole, diethylamine, piperazine, tris(hydroxymethyl)aminomethane, and tetramethylammonium.
The compounds of this invention are highly useful as antihypercholesterolemic agents for the treatment of atherosclerosis, hyperlipemia and like diseases in humans. They may be administered orally or parenterally in the form of a capsule, a tablet, an injectable preparation or the like. It is usually desirable to use the oral route. Doses may be varied, depending on the age, severity, body weight and other conditions of human patients but daily dosage for adults is within a range of from about 2 mg. to 2000 mg. (preferably 2 to 100 mg) which may be given in two to four divided doses. Higher doses may be favorably employed as required.
The compounds of this invention also have useful antifungal activities. For example, they may be used to control strains of Penicillium sp., Aspegillus niger, Cladosporium sp., Cochliobolus miyabeanus and Helminthosporium cynodnotis. For those utilities they are admixed with suitable formulating agents, powders, emulsifying agents or solvents such as aqueous ethanol and sprayed or dusted on the items to be protected.
In another aspect of this invention, it relates to a process for producing the compounds of this invention which comprises cultivating a microorganism belonging to the genus Penicillium and then recovering said compounds of this invention from the cultured broth.
The microorganisms which may be employed in this invention are the ones belonging to the genus Penicillium and, there is, for instance, mentioned Penicillium citrinum which has been deposited under an accession No. 2609 with Technical Research Institute of Microbial Industry, Agency of Industrial Science & Technology, Ministry of International Trade and Industry, Japan, and also NRRL-8082 in the Northern Regional Research Laboratory, Northern Central Region, Agricultural Research Service, U.S. Department of Agriculture, at Peoria, Ill., U.S.A.
Of particular importance in the production of Compounds I and II is a natural isolate of the above-identified species (NRRL-8082) which has been deposited in the American Type Culture Collection with Accession Number, ATCC 20606.
Although this invention is explained hereinbelow principally with respect to the specific strain, it is well-known in the art that various properties of all microorganisms belonging to the genus Penicillium are not definite, but the microorganisms of the genus Penicillium may be easily varied naturally and artificially. It is, accordingly, to be noted that all strains which are of the genus Penicillium and capable of producing compounds I and II, including varieties and mutants, are contemplated and usable in this invention.
The above strain is known and its morphological properties are reported in K. B. Raper and C. Thom; A Manual of the Penicillia, the Williams and Wilkins Company, 1949.
The culture of these organisms to produce the novel compounds is carried out in aqueous media such as those employed for the production of other fermentation products. Such media contain sources of carbon, nitrogen and inorganic salts assimilable by the microorganism.
In general, carboydrates such as sugars, for example, glucose, fructose, maltose, sucrose, xylose, mannitol and the like and starches such as grains, for example, oats, ryes, malt extract, cornstarch, corn meal, or oils such as glycerol, corn oil, soybean oil and the like can be used either alone or in combination as sources of assimilable carbon in the nutrient medium. The exact quantity of the carbon source or sources utilized in the medium depends in part upon the other ingredients of the medium but, in general, the amount of carbon sources usually varies between about 1% and 6% by weight of the medium. These carbon sources can be used individually, or several such carbon sources may be combined in the medium. In general, many proteinaceous materials may be used as nitrogen sources in the fermentation process. Suitable nitrogen sources include for example, yeast hydrolysates, primary yeast, soybean meal, cottonseed flour, hydrolysates of casein, corn steep liquor, distiller's solubles or tomato paste and the like. The sources of nitrogen either alone or in combination, are used in amounts ranging from about 0.2% to 6% by weight of the aqueous medium.
Among the nutrient inorganic salts which can be incorporated in the culture media are the customary salts capable of yielding sodium, potassium, ammonium, magnesium, calcium, phosphate, sulfate, chloride, carbonate, and like ions. Also included are trace metals such as cobalt, copper, boron, manganese, iron, zinc and molybdenum.
It should be noted that the media described in the Examples are merely illustrative of the wide variety of media which may be employed, and are not intended to be limitative. Specifically, the carbon sources used in the culture media to produce the novel compounds of this invention included dextrose, glycerol, malt extract and oatmeal. Included as nitrogen sources were autolyzed yeast, tomato paste, oatmeal, malt extract and corn steep liquor. The major added ionic component was CaCl2 and traces of Fe, Mn, Mo, B and Cu were also present.
The fermentation is carried out at temperatures ranging from about 22� to 26� C.; however, for optimum results it is preferable to conduct the fermentation at temperatures of from about 24� to 25� C. The pH of the nutrient media suitable for growing the Penicillium culture and producing the novel compounds can vary from about 4.0 to 7.0.
Although the novel compounds are produced by both surface and submerged culture, it is preferred to carry out the fermentation in the submerged state. A small scale fermentation is conveniently carried out by inoculating a suitable nutrient medium with the Penicillium culture and, after transfer to a production medium, permitting the fermentation to proceed at a constant temperature of about 25� C. on a shaker for several days.
The fermentation is initiated in a sterilized flask of medium via one or more stages of seed development. The nutrient medium for the seed stage may be any suitable combination of carbon and nitrogen sources. The seed flask is shaken in a constant temperature chamber at about 28� C. for 1-3 days, or until growth is satisfactory, and some of the resulting growth is used to inoculate either a second stage seed or the production medium. Intermediate stage seed flasks, when used, are developed in essentially the same manner, that is, part of the contents of the flask from the last seed stage are used to inoculate the production medium. The inoculated flasks are shaken at a constant temperature for several days, and at the end of the incubation period the contents of the flasks are centrifuged or filtered.
For large scale work, it is preferable to conduct the fermentation in suitable tanks provided with an agitator and a means of aerating the fermentation medium. According to this method, the nutrient medium is made up in the tank and sterilized by heating at temperatures of up to about 120� C. Upon cooling, the sterilized medium is inoculated with a previously grown seed of the producing culture, and the fermentation is permitted to proceed for a period of time as, for example, from 3 to 5 days while agitating and/or aerating the nutrient medium and maintaining the temperature at about 25� C. This method of producing the novel compounds is particularly suited for the preparation of large quantities.
The compounds are conveniently isolated from the fermentation broth as the lactone (I) by acidification to about pH 3-5, extraction with an inert organic solvent such as ethyl acetate, back extraction with dilute alkali, acidification, ethyl acetate extraction, concentration, lactonization and chromatography.
Compound I can be hydrolyzed with bases such as NaOH to yield the salts such as the sodium salt of Compound II. The use of bases with other pharmaceutically acceptable cations affords salts of these cations. Careful acidification of the salts affords the hydroxy acid II. The hydroxy acid II or its ammonium salt can be converted to Compound I by refluxing in toluene. Treating Compound I under acidic or basic catalysis with methanol, ethanol, propanol, or butanol or with phenyl, dimethylamino, or acetylaminoalkanols yields the corresponding esters of Compound II which also form a part of this invention.
A. Fermentation:
A natural isolate of Penicillium citrinum, NRRL 8082 was used to prepare a yeast-malt extract (YME) slant which was incubated for 2 weeks at 28� C.
A portion (1/5) of the slant (MF-4870a) was used to inoculate each of 5 unbaffled seed flasks (250 ml) containing 44 ml of KF seed medium with CaCl2. They were incubated for 3 days at 28� C., and 220 rpm. A portion of the seed growth (about 1.5 ml) was used to inoculate each of 100 production medium flasks (250 ml unbaffled) containing 40 ml of LM Production Medium Without Malt Extract. The production flasks were incubated for 4 days at 25� C.
Another group of production medium flasks (140), each containing 40 ml of LM Production Medium Without Modification were inoculated and incubated under the same conditions as previously described. The broths from both fermentations were combined.
The various media employed in the foregoing fermentations are:
______________________________________YME SlantDextrose 4 g./l.Malt Extract 10 g./l.Yeast Extract 4 g./l.Agar 20 g./l.Dist. Water to 1 literpH 7.0KF Seed Medium with CaCl2CaCl2 10 g.Corn steep liquor 5 g.Tomatoe Paste 40 g.Oatmeal 10 g.Cerelose 10 g.Trace Element Mix 10 ml.Distilled Water 1000 ml.pH 6.8Trace Element MixFeSO4.7H2 O 1 g.MnSO4.4H2 O 1 g.CuCl2.2H2 O 25 mg.CaCl2 100 mg.H3 BO3 56 mg.(NH4)6 Mo7 O24.4H2 O 19 mg.ZnSO4.7H2 O 200 mg.Distilled Water 1000 ml.LM Production Medium Without Malt ExtractDextrose 20 g.Glycerol 20 ml.Ardamine pH 10 g.CoCl2.6H2 O 8 mg.Polyglycol p 2000 0.25%Distilled Water 1000 ml.pH 7.0LM Production Medium Without ModificationDextrose 20 g.Glycerol 20 ml.Ardamine pH 10 g.Malt Extract 20 g.CoCl2.6H2 O 8 mg.Polyglycol p 2000 0.25%Distilled Water 1000 ml.pH 7.0______________________________________
B. Isolation
The combined whole broth (10.3 liters) was filtered and the mycelia cake was washed with 2.5 liters of deionized water. The combined filtrate and wash was adjusted to pH 4.0 with 1N hydrochloric acid. The aqueous solution was extracted with 7 liters of ethyl acetate and the extract was back-extracted with 3�2 liters of aqueous sodium hyroxide solution. The combined sodium hydroxide extract was adjusted to pH 3.8 with 1N hydrochoric acid and extracted with 2 liters and 1 liter of ethyl acetate. The combined ethyl acetate solution was dried over anhydrous Na2 SO4, filtered and concentrated to dryness. The oily residue was dissolved in toluene and refluxed for 1 hour. The toluene solution was concentrated to dryness and the residue was dissolved in 18 ml of a mixture of n-hexane/toluene/methanol (4/1/1 by volume). This solution was loaded onto a 30 mm (ID)�40 cm. Sephadex LH-20 column equilibrated in the same solvent system. After eluting with 300 ml of solvent, a 10 ml fraction was obtained which was concentrated to an oil. High performance liquid chromatography (HPLC) on an ES Industries ChromegaR column (9 mm�50 cm) using a mixture of acetonitrile/water (60/40 by volume) as the eluting solvent yielded 45 mg of dihydrocompactin (Compound I), m.w. 392.2560 by mass spectrum (calculated for C23 H36 O5, 392.2558)
In KBr, the major IR peaks obtained from a Fourier Transform-IR (FTIR, Nicolet, Model 7199) (FIG. I) are at 1724, 1704, 1258, 1078 and 1070 Cm-1. Of significance is a peak at 3005 Cm-1 and the absence of a peak at 3030 Cm-1.
A nuclear magnetic resonance spectrum (FIG. II) was obtained in CDCl3 (˜1 mg/0.5 ml) on a Varian SC-300 superconducting nmr spectrometer. The following are the peak positions given in ppm (δ) relative to internal tetramethylsilane (TMS).
______________________________________δ Assignment______________________________________5.62 d,d,d (2.17, 4.5, 10.0) H3' (d?)5.43 d (10) H4' (c?)5.20 m H8'4.63 m H64.39 m H42.75 d,d (17.5, 5.5) 3-CH22.63 d,d,d (17.5, 4.0, 1.5)2.39 m ##STR3##2.29 m H4a' + H5'1.14 d ##STR4##0.90 t CH3 CH20.84 d CH3 H5'______________________________________ d: doublet; m: multiplet; t: triplet
The evidence indicates the structure to be: ##STR5##
To a solution of 40 mg of the product of Example 1 in 2 ml of ethanol is added 1 ml of aqueous NaOH (10-4 moles; 1 equivalent). After one hour at room temperature, the mixture is taken to dryness in vacuo to yield the sodium salt of Compound II.
In like manner the potassium salt is prepared using one equivalent of potassium hydroxide, and the calcium salt using one equivalent of CaO.
The sodium salt from Example 2 is dissolved in 2 ml of water, cooled in ice and acidified slowly with 0.5M HCl. The mixture is extracted with ethyl acetate, back-extracted with water, dried over MgSO4 and filtered. The filtrate is treated with anhydrous ammonia with stirring and cooling to precipitate the ammonium salt.
To a solution of 0.50 g of the ammonium salt of Compound II in 10 ml of methanol is added 75 1 of ethylenediamine. The methanol is stripped off under vacuum and the residue is triturated with acetone, stored in the cold, and filtered to obtain the ethylenediamine salt of Compound II.
To a solution of 202 mg of the ammonium salt of Compound II in 5 ml of methanol is added a solution of 60.5 mg of tris(hydroxymethyl)aminomethane in 5 ml of methanol. The solvent is removed in vacuo and the residue triturated with a 1:1 mixture of acetonitrile:methanol. The desired tris(hydroxymethyl)aminomethane salt of Compound II is filtered off and dried.
A solution of 0.001 mole of L-lysine and 0.0011 mole of the ammonium salt of Compound II in 15 ml of 85% ethanol is concentrated to dryness in vacuo. The residue is triturated with 10 ml of warm ethanol, cooled, and filtered to give the L-lysine salt of Compound II.
Similarly prepared are the L-arginine, L-ornithine, and N-methylglucamine salts of Compound II.
A mixture of 68 mg of Compound I in 2 ml of methylene chloride and 0.08 ml of 24% tetramethylammonium hydroxide in methanol is diluted with ether to cause precipation of the tetramethylammonium salt of Compound II.
221 Mg of the ammonium salt of Compound II are dissolved in 4.5 ml of 65% ethanol, cooled in ice, acidified with abut 0.5 ml of 1M HCl to pH3, and evaporated at low temperature in a rotary evaporator to a volume of about 2 ml. 2 Ml more water are added, the mixture extracted into 2�3 ml of ethyl acetate, and backwashed with 1 ml of water, keeping all solutions cold in an ice bath. The extract is dried over MgSO4 and evaporated to dryness in vacuo to obtain the hydroxy acid as a colorless oil.
To a solution of 400 mg of the product, Compound I, in 100 ml of absolute ethanol is added 10 ml 0.1M sodium ethoxide in absolute ethanol. This solution is allowed to stand at room temperature for one hour, is then diluted with water and extracted twice with water, the ethyl acetate dried over anhydrous sodium sulfate is removed in vacuo to yield the ethyl ester of Compound II.
In like manner, by the use of equivalent amounts of methanol, propanol, butanol, isobutanol, t-butanol, amylalcohol, isoamylalcohol, 2-dimethylaminoethanol, benzylalcohol, phenethanol, 2-acetamidoethanol and the like, the corresponding esters are obtained.
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Wish I Could be There: Notes from a Phobic Life
Viking, 2007 - Biography & Autobiography - 267 pages
A droll, inquisitive, and poignant memoir of agoraphobia from a member of one of New York's premier literary families
Allen Shawn is afraid of heights, water, fields, parking lots, tunnels, and unknown roads. He avoids taking subways, using elevators, or crossing bridges. In short, he is afraid of both closed and open spaces and of any form of isolation. Yet this is a memoir of enormous bravery.
Shawn grew up in a lively but mysterious world. He is the son of the famous, longtime New Yorkereditor William Shawn and brother to the brilliant playwright and actor Wallace Shawn. His twin sister is autistic, and when they were eight years old, she was put in a home. Though it was kept from him until he was in his thirties, his father led a double life that introduced strict taboos to his household. Shawn examines these influences, his father's and mother's phobias, and his own struggle with agoraphobia with generosity, wit, and insight, attempting to decipher the psychological and biological puzzles that have plagued him for so long.
Interwoven with both Freudian psychology and cutting-edge brain research, Shawn has written a profound examination of familial love and the universal struggle to face our demons.
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Review: Wish I Could Be There: Notes From a Phobic LifeUser Review - Deanne - Goodreads
Behind a clever title lies an academic study of the history and nature of phobias completely void of humor or personality. Read full review
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only read 1/3, more science less bio than i expected Read full review

subset: commoncrawl


text:
→ Game Walkthroughs
Thread Locked
Posted May 5, '11 at 2:27am
1 post
hi all,just another fellow gamer with a issue hoping for a solution.my problem is this :every so often (like an hour or so) my game would freeze, or i die by accident, but when i load, the game would be loading save files forever (which means it doesn't show any saves, always show loading saves) and if i reload or refresh the web page, it would be exactly where i started in the first place. which make it almost impossible to proceed further in the game. this has been happening forever ! HELP !
Posted Jun 4, '11 at 7:18am
2 posts
1-right click on the game 2-click settings 3-click local storage 4-set local storage to unlimited and try again can i helped you
Posted Aug 3, '11 at 8:54am
5 posts
That won't work work me (e.g. in Castaway).It says, the game is saved, but the save slot is still empty.Any help?
Posted Jul 12, '13 at 12:43pm
I usually do global saving which needs a internet connection but i want to know if i can transfer the saving to local
Posted Jul 13, '13 at 3:47pm
11,220 posts
There should be an autosave for both local and global if you're playing it on the same computer. You should be able to create a local save after you load a global save if you're on a different computer.Locking this thread because it's over two years since the previous post. Please create a new thread if a recent thread (one within the last couple months) doesn't already exist.
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Most outstanding paper in American Journal of Sports Medicine 2014
Björn Barenius and Sari Ponzer orthopaedists at Södersjukhuset and researchers at the department, was along with their co-authors chosen to receive the Hughston Award for the most outstanding paper in American Journal of Sports Medicine 2014. The award ceremony took place this summer at the Annual Meeting of American Orthopaedic Society for Sports Medicine in Orlando. Click here to read full article.
Manske Award winners for best article 2014
KI SÖS congratulates Marianne Arner and Anna Gerber Ekblom on winning the Manske Award 2014. The award was presented to all the authors, for the best upper extremity congenital research paper published in the previous year, at the Rotterdam International Congenital Hand meeting in May. Read the award winning article here.
Best Swedish vascular surgery article 2014
Our researcher Anneli Linné and her colleagues at Karolinska Institutet, has received an award for best Swedish vascular surgery article in 2014. The article published in the British Journal of Surgery, analyses the reasons why men fail to participate in the abdominal aortic aneurysm screening programme.


text:
March 26, 2006
WEST POINT, N.Y. - The Holy Cross women's tennis team was unable to pick up their second victory of the spring season as they fell to Army 7-0 on Sunday afternoon. After defeating Assumption at the Paxton Sports Center on February 18, the Crusader women have fallen in three straight decisions.
The Black Knights (9-11, 2-0) cruised to the shutout win over the Crusaders (1-4), sweeping all six singles and all three doubles matches on the day. The shutout was the second of the season for Army.
Holy Cross will be back on their home courts on Saturday, April 1 when they host Manhattan at 12:00 p.m.
Final Results
1. Sarah Giles-Madden (A) def. Meg Moran (HC) 6-0, 6-0
2. Jessica Shurtz (A) def. Amy Garrity (HC) 6-1, 6-0
3. Bridie Burke (A) def. Katie Guarino (HC) 6-0, 6-0
4. Mary Ford (A) def. Meredith Bacon (HC) 6-1, 6-1
5. Kate Houghton (A) def. Melanie Bunke (HC) 6-0, 6-2.
6. Christine Limsiaco (A) def. Ginienne Santoro (HC) 6-1, 6-1
1. Shurtz/Kristin Flach (A) def. Kerry Trimmer / Carrie Simmons (HC) 8-1
2. Giles-Madden/Brooke Jones (A) def. Moran/Garrity (HC) 8-0
3. Burke/Houghton (A) def. Bacon/Guarino (HC) 8-0


text:
On the morning of December 10, 1983, Searle Drugs CEO Donald Rumsfeld flew into Baghdad for an historic meeting with Iraq's President Saddam Hussein. He was acting as a special envoy under the orders of President Reagan, who two weeks earlier had initiated policy aimed at preventing Iraq from losing its war with Iran, citing the need to protect America's Persian Gulf oil interests and regional military strength. (1)
Rumsfeld was no stranger to diplomacy; he'd been Secretary of Defense under Gerald Ford and was an Illinois Congressional Representative from 1962 to 1969. However, this was the first time a White House representative would meet with Hussein.(2)
The flamboyant Hussein was characteristically warm, articulate and charming, though by then it was well-known that he had been engaging in "almost daily use of CW [chemical weapons]". (3)
The two discussed the Iran-Iraq war and the U.S.'s efforts to find alternative oil transportation routes; its Persian Gulf facilities had been shut down by Iran, and Syria, Iran's ally, had cut off a pipeline transporting Iraqi oil through its territory.
They also touched upon Lebanon, strengthening Egyptian-Iraqi ties, and, what would prove to be the crowning irony "...the threat of terrorism, which targets both countries." (4)
It was Rumsfeld's task to ensure the dictator had whatever it took to defeat Iran. This opened the door to some of the most breathtakingly amoral, politically expedient alliances, black-market deals and betrayals ever documented in modern history.
It's almost impossible to conceive of a nastier set of transactions than the backroom funneling of weapons, money and military support to the regime of Saddam Hussein, not to mention his subsequent betrayal for possessing precisely the same weapons and money.
In his 1995 affidavit, National Security Council official Howard Teicher relates in general terms of how Ronald Reagan, George Bush Sr., Donald Rumsfeld and CIA director William Casey provided billions in US aid to Hussein, along with cluster bombs and other "unspecified munitions". (5)
Fortunately, with a little digging, we can get much more specific than Teicher:
Throughout the early 1980s, the National Security Council, CIA and other government agencies approved loans of more than $5 billion to Iraq through the Atlanta branch of the Italian Banca Nazionale del Lavoro (BNL).
"About half of the money allegedly went to finance the purchase of US farm products, including $900 million guaranteed by the Agriculture Department's Commodity Credit Corp., but investigators said much of the rest had helped fuel Iraq's military buildup," wrote George Lardner in the Washington Post on 22 March 1992. He was citing information provided by chairman of the House Banking Committee Rep. Henry B. Gonzalez. (6)
Hussein used the remaining funds to buy "...computer-controlled machine tools, computers, scientific instruments, special alloy steel and aluminum, chemicals, and other industrial goods for Iraq's missile, chemical, biological and nuclear weapons programs." Then in 1982, Reagan authorized direct military assistance to Iraq:
"...This resulted in more than a billion dollars in military-related exports. According to Kenneth R. Timmerman (author of The Death Lobby: How the West Armed Iraq) the US government under Reagan and Bush sold Iraq 60 Hughes MD 500 "Defender" helicopters, eight Bell Textron AB 212 military helicopters equipped for anti-submarine warfare, 48 Bell Textron 214 ST utility helicopters (sold for "recreational" purposes), and US military infra-red sensors and thermal imaging scanners (sold illegally to Iraq through a Dutch company). After the Gulf War, the International Atomic Energy Agency found the following US equipment in Iraq: spectrometers, oscilloscopes, neutron initiators, high-speed switches for nuclear detonation, and other tools used to develop and manufacture nuclear weapons."(7)
By this time, it had largely become George Bush, Sr's. game. As Ted Koppel explained in June, 1990, "...George Bush [Sr.], operating largely behind the scenes throughout the 1980s, initiated and supported much of the financing, intelligence, and military help that built Saddam's Iraq into the aggressive power that the United States ultimately had to destroy."(8)
Most of the documentation has since been declassified, disclosing specific sales of helicopters to the Iraqi ministry of defense (9), heavy trucks for military purposes (10) and so-called "dual-use" hardware, including materials for the manufacture of nuclear weapons (11)
Nor, according to the NY Times, was the White House content with just giving Hussein special gifts:
"...60 officers of the Defense Intelligence Agency were secretly providing detailed information on Iranian deployments, tactical planning for battles, plans for airstrikes and bomb-damage assessments for Iraq." (12)
Then, in 1985, they stepped up the pace; the US Commerce Department licensed the first of 70 shipments of bioweapons to Iraq. What Senator Robert Byrd characterized as a "toxic brew" of the world's deadliest agents were delivered to the Hussein regime. They included botulinum toxin -- according to the American Medical Association the deadliest substance known to man -- 21 lethal strains of anthrax, and a gaseous form of gangrene, the deadly flesh-rotting disease. Complete detailed catalogs survive of the chilling arsenal with which the Reagan and Bush Administrations armed Hussein.(13)
Flash forward 17 years; On December 7, 2002, in the leadup to the Iraq invasion, Hussein's government released its 12,000-page weapons-program dossier to the UN Security Council.
The Bush Administration seized the dossier and censored 8,000 pages, much to the public's shock and puzzlement. The reasons were quickly made apparent, however, when the original dossier was leaked to the German daily Die Tageszeitung:
24 US firms had been named as suppliers of WMD technology to Iraq, along with the ministries of defence, energy, trade and agriculture and the Lawrence Livermore, Los Alamos and Sandia National Laboratories.
Hewlett-Packard, Dupont and Eastman Kodak had been specifically named, along with '50 subsidiaries of foreign enterprises [who] conducted their arms business with Iraq from the US' (14)
All 24 can be found at the link below, along with a list of their specific "contributions" to the people of Iraq and Iran. (15)
But in all fairness, it isn't just America's right-wing fruitbats who betrayed the security and trust of their citizens and millions around the globe; 17 British companies were also fingered for supplying Hussein with nuclear, biochem, rocket and conventional weapons technology. And five permanent members of the security council -- Britain, France, Russia, America and China -- were also involved, as were Japan, Holland, Belgium, Spain, Sweden and Germany.
Still, one cannot help but experience a special inner glow when hearing of the role played by our friend and ever-staunch ally, Israel:
"Shortly after the beginning of the Iran-Iraq war, the U.S. embassy in Ankara reports that Turkish ports have a backlog of goods awaiting transshipment to Iraq, and that a substantial amount of Israeli goods transit Turkey for "Islamic belligerents," including Israeli chemical products for Iran. It remarks on "Israeli acumen" in selling to both Iran and Iraq." (16)
1. National Security Decision Directive 114: "U.S. Policy toward the Iran-Iraq War," November 26, 1983
2. Video clip: December 20, 1983 -- Saddam Hussein greets Donald Rumsfeld in Baghdad
3. National Security Archive: declassified State Department Telegram
4. National Security Archive: declassified State Department Telegram
5. National Security Council agent Howard Teicher's sworn affidiavit:
6. George Lardner, Washington Post, March 22, 1992
7. Kurt Nimmo, "Bush Senior: Hating Saddam, Selling Him Weapons" AlterNet, September 23, 2002
8. Ted Koppel, "Nightline", ABC News, June 9
9. National Security Archive: declassified State Department Telegram
10. National Security Archive: declassified State Department memo
11. National Security Archive: declassified State Department memos
12. "Officers Say U.S. Aided Iraq in War Despite Use of Gas", Patrick E. Tyler, NY Times, Aug 18, 2002
13. "U.S. Exports of Biological Materials to Iraq" - Senator Donald W. Riegle, Jr., Chairman Senate Committee on Banking, Housing, and Urban Affairs report to Congress, May 25, 1994
"A U.S. Gift to Iraq: Deadly Viruses" Business Week, September 20, 2002
14. "Revealed: 17 British firms armed Saddam with his weapons", Neil Mackay, Sunday Herald, Feb. 23, 2003
15. http://www.thememoryhole.org/corp/iraq-suppliers.htm
(Note particularly the presence of Bechtel, which the astute reader will recognize is STILL providing "services" to Iraq during the current conflict.)
16. National Security Archive: declassified State Department Telegram
Quote of the Day: "Sometimes to be silent is to lie."
- Miguel Unamuno
Friday, February 24, 2006
How We Came to Own Iraq (Repost)
Posted by New American Patriot at 3:10 PM
1 comment:
Bravo! Hussein is America's frankenstein!
Subscribe to: Post Comments (Atom)


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"It takes a lot more than just an inclusive business climate to send you on a path of success. You need help opening the door and then navigating the environment behind that door." – Brett Carter
Access Charlotte is not just another networking or card-trading group. It is a transformative organization facilitating access to some of the most accomplished, talented, respected and well-known business people in the region. These are business leaders who are personally committed to building a pipeline of the region's next generation of senior level executives.
Access Charlotte brings together senior-level minority executives and emerging minority business leaders, across various industries, for the purpose of strategically cultivating the pipeline of local minority executives.
Friends and Partners
"Access Charlotte's mission will help us act together to realize mutually beneficial outcomes, meet the evolving needs and aspirations of all stakeholders, and sustain the Charlotte region into the future." – Kevin Henry
We are successful businessmen and women of color who respect and honor our history, all the while knowing we can improve of our futures together.
It's about Economic Development… as we begin the work of building Charlotte's regional global competitiveness, we must not only attract diverse senior executives, but retain that talent in the region.
It's about Community Leadership… because performance and hard work get top talent recognized and promoted. But "potential" isn't enough to propel men and women into the executive suite. Top jobs often elude minorities because they lack the right leaders to champion their growth.
Ultimately, it's about Community Vitality… Our focus groups revealed that over the years, local minority executives have accumulated substantial cultural capital, (non-monetary wealth and relationship capital generated outside the workplace) which is undeniably vital for organizations who wish to exert influence in a community or a company. In the case of minority professionals, cultural capital is unusually rich.
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" It's candid and unabridged truth about their leadership journeys and what happens after the workshops and seminars are over." – Robyn Hamilton
The sessions are not "workshops." This is an opportunity to understand how to chart a course to C-suite positions, while realizing the nuances to be a minority in today's corporate environment. This is about building effective relationships with current and other emerging executives who are interested in helping rising minority executives achieve greater levels of success on their ascent to senior leadership roles.
|The Unabridged Version of Leading to the Top
The Philanthropy of Time
|March 28, 2013
|Brett Carter, Chief Distribution Officer, Duke Energy,
Mike Jones, Chief Merchandising Officer, Lowe's Companies, Inc.
|The Art of Executive Presence
Be In the Room, When You Aren't In the Room
|May 23, 2013
|Jesse Cureton, EVP and Chief Consumer Officer, Novant Health,
Claudette Hampton, SVP – Chief Human Resource Officer, Lending Tree
Cedric Coco, SVP of Learning and Organizational Effectiveness, Lowe's Companies, Inc.
|Once the Seminar/Workshop is Over
The Investment of Pedigree
|July 25, 2013
|Debra Plousha Moore, EVP and Chief Human Resource Officer, Carolinas Healthcare System
Richard (Stick) Williams, SVP Environmental Health & Safety and President of The Duke Energy Foundation, Duke Energy Corporation
|GPS Won't Help Navigate Culture
Why Recruiters Won't Submit Candidates
|September 26, 2013
|Frank Emory, Partner, Hunton & Williams
Lloyd Yates, EVP Regulated, Duke Energy
Christopher Braswell, Partner, BMG USA
|Managing Between the Gap "V.P. to CEO"
The Journey from Corporate Life, to High Growth Entrepreneur
|November 14, 2013
|Kevin Henry, Chief Human Resource Officer, Snyder's-Lance
Bridget-Anne Hampden, Deputy Chief Information Officer, Office of Federal Student Aid, U.S. Department of Education
Gene Waddy, CEO, Diversant
|Renaissance Gathering of Executives and CEOs
|January, 2014
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Emerging Executives
Emerging minority executives will have a unique and unprecedented opportunity to interact and hear from Charlotte's top minority executives and business leaders to help achieve greater levels of personal and professional success. These sessions promise to offer candid and unabridged conversation about their leadership journeys while challenging participants to take specific actions upon leaving the discussions. This is about more than a career development plan. They will share insight to navigating leadership styles, organization politics, and key factors that influence senior leader.
|Nicole Dean
|Vice President of Internal Audit
|Belk, Inc.
|Reginald Bean
|Director-Multicultural Marketing
|Coca-Cola Bottling Co. Consolidated.
|Sherill Carrington
|Director, Key Market Segments
|United Way of Central Carolinas
|Patrice Funderburg
|Transformative Consultant
|Funderburg, LLC
|Ophelia Garmon-Brown
|Senior Vice President, Physician Services
|Novant Health
|Patrick Graham
|Urban League of the Carolinas
|Jada Grandy
|Senior Vice President of Community Development
|Fifth Third Bank NC
|Robyn Hamilton
|Corporate Relations
|Novant Health
|April Harley
|Political Consultant & Fundraiser
|The Harley Firm
|Chris Hemans
|Director of Economic Development
|Charlotte Center City Partners
|Clyde Higgs
|Vice President, Business Development
|Castle & Cooke
|Sid Levy
|Senior Director, Communications and Community Relations
|Nichelle Nicholes Levy
|Digital Counsel, Legal
|NASCAR Digital Media
|Todd Pipkin
|Head Master
|The Male Leadership Academy of Charlotte
|Kevin Price
|Supplier Diversity & Performance Manager
|Novant Health
|Felicia Robinson
|Vice President Compensation & Benefits
|Belk, Inc.
|Henry Rock
|Executive Director
|City Startup Labs
|David Sharp
|Urban Advisors
|Charles Thomas
|Executive Director
|Queen City Forward
|Regina Wharton
|Senior Vice President, Human Resources
|Fifth Third Bank NC
|Anika Khan
|Senior Economist
|Wells Fargo Securities, LLC
|Onyeka Nchege
|Vice President & CIO
|Coca Cola Bottling Co. Consolidated
|Alvin "Al" Austin
|Major Gifts Officer
|Johnson C. Smith University
|Alisa McDonald
|Director of Community Involvement & VP
|Duke Energy Foundation
|Cy Kennedy
|American Product Distributors
|Felicia Robinson
|VP Compensation Benefits Payroll Associate Engagement
|Belk, Inc.
|G. Patrick Griffin
|Vice President
|Carolina's Healthcare System
|Joni Davis
|VP Large Account Management Regulated Utilities Operations
|Duke Energy
|Joy Paige
|VP Institutional Advancement
|Johnson C. Smith University
|Manwell Bynum
|President & CEO
|Connectivity Concepts, LLC
|Osyris Uqoezwa
|President & CEO
|B & C International
|Ron Tate
|Operational Supplies & Services Executive
|Bank of America
|Timothy Atwell
|SVP, Business Executive – Technology, ATM
|Bank of America
|Tanya S. Blackmon
|Presbyterian Hospital Huntersville
|George Williams
|Client Engagement Executive
|TPM Consulting, Inc.
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Access Charlotte formed to help Charlotte's top black executives and entrepreneurs thrive
Inside a classroom at the uptown Foundation for the Carolinas on a recent afternoon, 35 listeners hung on every word from two high-ranking executives.
Brett Carter, chief distribution officer and senior vice president for Duke Energy, and Michael Jones, chief merchandising officer for Lowe's Home Improvement, were offering advice on moving up the ranks.
And the listeners – handpicked for being rising corporate and entrepreneurial stars in the Charlotte region – were taking it all in.
Jones spoke of working within the "guard rails," or the norms of corporate life. "You can be creative," Jones explained, "but if you go outside … you run the risk of being misaligned with the organization."
Carter talked about the importance of finding mentors.
"You've got to pick the right people. That's key," Carter told the group. "… You've got to figure out who in that shark tank is really a shark."
It was all part of the launch of Access Charlotte, a new leadership forum. Black business leaders created the group to identify, counsel and retain minority executives and high-growth entrepreneurs in the region.
Managers from businesses including Belk, Wells Fargo, NASCAR, Bank of America, Novant Health and other companies get career advice from some of the area's well-known black executives and entrepreneurs serving as advisors.
Nearly 20 leadership advisors are involved, including Frank Emory, a partner with the law firm Hunton & Williams and former chair of the Charlotte Chamber; Debra Plousha Moore, chief human resources officer and an executive vice president with Carolinas HealthCare System; Venessa Harrison, president of AT&T North Carolina; and cardiologist Dr. Yele Aluko, senior vice president for Novant Health Heart and Vascular Services.
Competition to be selected for the group as a student, called "emerging leaders," was heavy, Carter said.
Read more at Charlotte Observer.
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We are leaders with an appreciation of what we have learned and accomplished. We believe in sharing what we have learned to help others on their own professional journey. We aspire to create a sustainable organization worthy of honoring those who have come before us.


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Adoption ceremony provides early Christmas gift
23 Bexar County families make adoptions official
SAN ANTONIO - "(It's) the best gift ever," responded a teary Kerri Butler, when asked about her newly adopted son Christian.
It may be a week early, but for Butler, her Christmas gift could not have come soon enough.
"I can't even describe it; just complete joy," said Butler.
The joy is courtesy of 20-month-old Christian, a youngster who needed a home.
"We just had it in our hearts to take a huge leap of faith and step out. We prayed. He just kind of came to us nine months ago, which was kind of funny," said Butler.
On Friday, the Butlers officially adopted the newest addition to their family. They joined many more families with similar stories at the Bexar County December Adoption Day Ceremony, Friday morning.
Bexar County is no stranger adoptions; in fact, it has the distinction of leading not only the state, but the nation in adoptions.
On Friday, 37 children were adopted to 23 families.
That includes the Reyes family, who spent the past two years attempting to adopt their granddaughter, Arianna. As of Friday, they now have the Christmas gift they have been waiting for.
"It's a wonderful gift. Yes, we couldn't ask for more," said Grandmother Alicia Reyes.
Neither could Samira Washington, who decided to give her three nephews, ages 4, 5 and 7, the gift of a forever home.
"It is a big gift to just bring it all together and make it happen," said Washington.
It is a Christmas gift that the many new parents who attended, will likely cherish for a lifetime.
"He's such a gift. He's incredible and very loved--lots of love and he knows it," added Butler.
Copyright 2011 by Post-Newsweek Stations. All rights reserved. This material may not be published, broadcast, rewritten or redistributed


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- 6 total posts
- 1 review
- 5 comments
Reviews by Skisteve007
Male Tummy Tuck W/ Gynecomastia, Lipo to Flanks - Denver, CO
41 yrs old. 245 lbs down from 320lbs. Always been athletic and in the gym. I believe I have good under lying muscle tone. Belly and chest never seem to go down. I'm scared as hell and hoping I made the right decision with this. Just to clarify I opted for the extended TT, power assisted... READ MORE
Recent comments from Skisteve007
10 days since your last post how are you feeling? READ COMMENT
How things going READ COMMENT
Thanks for the post , my condition is the same. So it looks like he did lipo? no excisions , correct? Looks great too. good choice ! READ COMMENT
Wow... thank you so much for the reply . I was hoping to get someone with the same as me. I'm still scared and nervous. I felt the same as you after I had gastric Placation going to severely over weight folks and telling them to do it.... READ COMMENT
I'm doing this same procedure and I'm scared as hell! Wonder how the chest lipo turned out after the six months? Dr. Recommended cutting out the tissue but I didn't want that scare. Nervous, READ COMMENT


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When Leryn Franco glided into the Beijing National Stadium during the Olympic Opening Ceremony, the world's collective head turned and its collective jaw dropped. No one knew the identity of the phenomenally beautiful athlete, and so the media went into overdrive to find out. Turns out that Leryn Franco is a 26-year-old Paraguayan javelin thrower, and (no duh!) a model. A runner-up in the 2006 Miss Paraguay competition, Leryn supposedly uses modeling to help subsidize her althletic endeavors. She was also in the 2004 Olympics.
Yesterday, Leryn finished second-to-last in the javelin qualifying round with a throw that was 12 meters short of her personal best. This makes her the Most Talked About Olympic Athlete Who Failed To Qualify For An Event.
P.S. As evidenced by the photos below, we clearly messed up by not including Leryn in our Top 10 Hottest Hotties of the 2008 Olympics.
[Top photo: Splash News Online and Getty Images]


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Last week, the Butler County Community College Board of Trustees spoke loudly. Members unanimously approved an early extension of my contract to lead the college.
To say that I was overwhelmed by their support would be an understatement. Just like when I was appointed to the position in August 2007, my appreciation of the board, faculty, staff, students and entire Butler community is sincere.
On Monday evening, a new member of the community was welcomed to Butler. Ironically, just five days after the college renewed its faith in me, one of the individuals responsible for my success was named the Butler High football team's head coach, Jim Rankin.
My grandparents taught me courage as immigrants to this wonderful country. My father taught me work ethic as a manual laborer who gutted it out in the steel mill. My mother led by example when she cared for my terminally ill father and owned her own business.
And Coach Rankin taught me to believe in myself. Taking over a fledging football program is nothing new for Rankin. In 1979, he took the helm of the Ellwood City High School program, which hadn't enjoyed success since a 7-3 season in 1969.
Several coaches came and went during the decade of the 1970s, but still there was losing football in a town, just like Butler, where football reigns king.
Rankin started slowly with a 1-9 mark in his first year. But immediately, he set the tone. He benched the starting quarterback from a well-known family. Two players who had long established roots in Ellwood City transferred to a private school.
But an offseason weight program was established. I was a clumsy eighth grader, he invited me to the workouts.
He established fundraisers like an annual football lift-a-thon, jewelry sales yes, jewelry and suntan lotion sales.
All benefited our football program and built togetherness in the process.
Through 1-8-1, 2-8 and 4-6 seasons from 1980-82, one could sense the momentum building. Players and members of the student body donned T-shirts that read, "Ellwood City Guaranteed Tough" and "Big Team, Little Me."
Then, in 1983, my junior year, we did it a winning season with a 6-4 record. We even beat defending WPIAL Class AA champion Beaver.
Before my senior year in 1984, I overheard Rankin say, "He's going to be successful in life" as he pointed to me. Yeah, my relatives would say the same, but that was Coach Rankin. The impression is still etched in my mind.
I can reflect on those hot summer camps, brutal practices and never-say-no weightlifting sessions and know they prepared me for life's battles. My former teammates said the same when we honored Coach Rankin after he entered the Pennsylvania Interscholastic Football Hall of Fame.
I was one of more than 70 former players who did so in 2006.
We finished with another 6-4 record in 1984, the first such Ellwood City team to be part of back-to-back winning seasons in more than 20 years. A win over WPIAL Class AA runner-up and archrival Riverside capped the season.
In 1985, Ellwood City qualified for the playoffs for the first time since 1944 by winning seven games. A year later in 1986, my brother Mike's senior season, Ellwood City captured the MAC championship and won a playoff game before injuries ended a 10-2 campaign.
When Rankin left for North Allegheny High School, he amassed a 37-44-1 record at Ellwood City. From 1983 to 1986, Ellwood City achieved a 29-14 mark. His team's records never worsened during his tenure. Each year, we got better; from 1-9 in 1979 to 10-2 in 1986.
He even set the stage for Ellwood's 11-2 record in 1987 and two 7-3 records to end the decade in 1988 and 1989.
Of course, his greater success came at North Allegheny High, where he won PIAA and WPIAL Class AAAA championships in 1990. Overall, he earned a 144-62-2 record at North Allegheny with three WPIAL Class AAAA runners-up.
There are striking similarities between the situation Rankin faces at Butler and what he faced in Ellwood City 30 years ago.
He changed a culture of losing to winning. He did it his way. He did not let parents interfere.
As players, we abided by his rules no exceptions. He worked us, drilled us and disciplined us. Like Bear Bryant or Bobby Knight, he was "old school."
Look no further than the president's office at Butler County Community College for a person who knows Jim Rankin will do the same at Butler High.
By NICHOLAS C. NEUPAUER
Welcome Day
Orientation @ BC3
Dates and times for all BC3 locations
BC3 Trustee Op-Ed
Butler Eagle 2.4.13
BC3's Fund Balance Isn't Too Large (pdf)
BC3 Strategic Initiatives
View details about BC3's four Strategic Initiatives
BC3 Financial Summary
BC3 Financial Summary(pdf) January 24, 2013
BC3 Master Plan
View BC3 Master Plan(pdf)
Economic Impact Study
View BC3's 2012 Economic Impact Study (pdf)


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iHerb 상품평
Excellent product
7 명의 이용자께서 다음의 상품평이 유용함을 확인하셨습니다.
Reviewer2429494님께서 Jan 29, 2012 에 작성하셨습니다.
I've tried a number of other brands Turmeric capsules, but Eclectic Institute Turmeric seems to be the purest and most effective. I used it to aggressively treat cellulitis of my left forearm. I drank a Turmeric cocktail (heaping teaspoon of Turmeric, black pepper, olive oil or coconut oil, hot water, V8) in the morning and at bedtime, and took 3 Eclectic Institute Turmeric capsules every four hours. Within 36 hours you could not tell which forearm had the cellulitis!
Great product
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Reviewer2798027님께서 Apr 28, 2009 에 작성하셨습니다.
Good for inflammation, been taking turmeric for a long time and this is the best brand I have tried.
smell and see the goodness
5 명의 이용자께서 다음의 상품평이 유용함을 확인하셨습니다.
Reviewer2164061님께서 Feb 28, 2012 에 작성하셨습니다.
Upon opening the bottle, I could smell the fresh, wonderful turmeric smell. Unlike capsules, I could also see the bright yellow turmeric powder inside the gel capsules. I can't really tell whether it's better in terms of potency compared to the cheaper counterparts, all I know is I can see and smell the goodness of turmeric with this brand. I also like that it's fresh, freeze-dried, as opposed to just extracting the oil with the "standardized extract" versions.
Indian spices are important
3 명의 이용자께서 다음의 상품평이 유용함을 확인하셨습니다.
Reviewer1587798님께서 Nov 06, 2009 에 작성하셨습니다.
A study in Singapore showed that Chinese who ate curry at least once a week had lower incidence of age-related mental problems. Although I eat curry once a week, I take one of these a day as well. Organic and vegetarian. Eclectic Institute is my primary source for herbs.
Great Product
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Reviewer2655629님께서 Jan 12, 2008 에 작성하셨습니다.
Sometimes this particular Eclectic Institute product is hard to find -- but iherb had it!


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For 40 years, Hamburger Helper® has helped to make family dinner time easy, and now with two new delicious varieties, Ultimate Beef Stroganoff and Cheesy Italian Beef, Hamburger Helper offers even more options for easy family style cuisine. With naturally- flavored mixes and rich, tasty sauces, Hamburger Helper makes a meal your family will be […]
Giveaway: Hamburger Helper Kitchen Prize Pack #MyBlogSpark
March 18, 2012 By
This post may contain affiliate links - any opinions stated are strictly my own!
Save Money on your next Hamburger Helper Purchase!
November 17, 2010 By
A few months ago, select Hamburger Helper fans from around the country had the chance to host a fun MyGetTogether to learn why it has been a dinnertime favorite for busy families for four decades. MyGetTogether is an exciting new program where hosts and guests get to experience a General Mills brand or product during […]
This post may contain affiliate links - any opinions stated are strictly my own!


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New York on the Potomac
Washington news with a New York state of mind
Posts filtered on Category
Richard Holbrooke, Democratic foreign policy voice from Vietnam to Afghanistan, dies at 69
Richard C. Holbrooke, the globetrotting diplomat who sought to bring the lessons of Vietnam to the forefront of the contemporary debate about Afghanistan, died Monday in Washington. He was 69. Holbrooke, the State Department's special representative for Afghanistan and Pakistan, was one of the preeminent Democratic voices on foreign policy in recent decades, and his […] [Read More]
Handicapping the Supreme Court prospects
THE SUPREME COURT CONTENDERS NAME CURRENT JOB ODDS Elana Kagan U.S. Solicitor General 3:1 Merrick Garland Federal appeals court judge 4:1 Diane Wood Federal appeals court judge 6:1 Hillary Clinton Secretary of State 10:1 Janet Napolitano Secretary of Homeland Security 12:1 Jennifer Granholm Governor of Michigan 15:1 Deval Patrick Governor of Massachusetts 20:1 Harold Koh […] [Read More]
Today in NY History: Yankees great Babe Ruth is born
New York on the Potomac is pleased to launch a new feature: Today in New York History. NYPotomac's Diana Carlton will fill us in on historical events that took place on this date, with links for you to get more information. 1843: The first minstrel show in the United States, "The Virginia Minstrels" opens at […] [Read More]
Hillary gets boost during Haiti earthquake recovery
Nearly three out of five U.S. voters now give Secretary of State Hillary Clinton a thumbs up, according to new polling data from Rasmussen Reports. A telephone survey by Rasmussen Reports found that 58 percent of likely U.S. voters have a favorable view of the former first lady and New York senator — a slight […] [Read More]


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|Finnish Worker's Society "Kehitys" Archive (Cloquet, Minn.).
|Records (1911-1939) of the Finnish Workers' Society "Kehitys" (Cloquet, Minn.) Archive consist of financial records; minutes; membership lists; and play scripts.
|4 microfilm reels.
|In Finnish.
|Collection ID:
The Finnish Workers' Society "Kehitys" of Cloquet, Minn., was founded in 1903 as the "Edistys (Progress)" Workers Association. In 1906 it joined the Socialist Party and the Finnish Federation of the Socialist Party (United States). It also changed its name to "Kehitysseura (Educational Society). During the 1914 socialist-industrial unionist schism the group withdrew from all national organizations and became an independent workers' society. Although both factions participated in its activities, and although industrial unioinists appear to have been in the majority, the group never formally joined the IWW.
The Finnish Workers' Society Kehitys, Cloquet, Minnesota collection is available for public research.
The Finnish Workers' Society Kehitys, Cloquet, Minnesota collection is the physical property of the Immigration History Research Center, University of Minnesota.
For further information regarding the copyright, please contact the IHRC.
The Finnish Workers' Society Kehitys, Cloquet, Minnesota Records, Finnish American Collection, Immigration History Research Center, University of Minnesota
|Finnish Americans--Minnesota--Cloquet--Political activity.
|Finnish American Socialists.
|Finnish American theater.
Back to all finding aids in IHRC Archives.


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Bigger is Better for WVU's Patterson
Maybe it's because Keith Patterson's father was once a basketball coach, but if you haven't noticed lately, West Virginia's defense is getting longer, leaner and more athletic.
This has been an evolution a couple years in the making, and it's in direct response to the athletic and dynamic spread offensive teams West Virginia is now facing in the Big 12. The days of defending 50-60 plays in a ball-control-style football conference against shorter, squattier-type offensive players are now over.
"With length, when you drop into zone coverages now, because everyone is trying to run the ball to the bubble, or trying to throw it into the creases of the defense, well, when you have guys who are 6-3, 6-4, 6-5 dropping into coverage with their big wingspans those creases become smaller," Patterson explained.
Put another way, having bigger defenders makes it much tougher for offenses to throw the ball or run it in most situations, says Patterson.
"Now, the creases also become taller so the ball has to be elevated to be able to get it over to someone into the boundary," he said. "The ball has to be thrown with a little more zip to be able to get it into that smaller window. I just think when you have bigger, longer, athletic guys it makes the size of those windows much smaller."
I can recall several years ago, prior to West Virginia's 2006 Sugar Bowl meeting against Georgia, Mountaineer defensive coaches being very concerned about the fact that they didn't have anyone on their roster capable of matching up against the Bulldogs' 6-foot-8-inch tight end Leonard Pope.
All of the second-level players West Virginia had available to cover Pope were just 6-feet tall or shorter, meaning the Mountaineers were at a clear disadvantage if Georgia chose to consistently attack the middle of the field with its tight end.
But fortunately for West Virginia, the Mountaineers got off to a big early lead and Georgia was forced to go to a more frenetic pace to catch up and it didn't have the time to fully capitalize on the clear advantage it had in the deep middle part of the field with Pope.
I also remember for years marveling at the impressive length and size of the players Virginia Tech began recruiting later on when the Hokies really got things going under Frank Beamer. The 6-foot edge rushers Tech used to have with players like Cornell Brown and Corey Moore later became 6-3, 6-4 guys, and consequently, West Virginia had a much more difficult time getting over top of them or around them.
And that is what Patterson is trying to develop at WVU.
"With (Dontrill) Hyman and Will Clarke, there are times when we can really be impressive up front," he said. "Kyle Rose is 6-4 and those guys look normal size. Then you look at our linebackers and they are all over 6-foot tall. (Brandon) Golson and Dozie Ezemma are 6-1, 6-3 guys on the edge. To me, we've got to continue to get more length in the secondary, but with our recruiting plan we have a plan for where we're headed and we have definitely taken steps in that direction."
"This recruiting class we just had come in you're talking about some of those linebackers, some of those DBs, they're all over 6-1, 6-2, 6-3 and you look at the D-linemen we've brought in at 6-4, 6-5," said secondary coach and ex-defensive coordinator Brian Mitchell. "Like KP (Patterson) says, how do you defend the spread? You've got to get bigger, longer, rangier players that can be better space players and that's the challenge we're going to have in the Big 12. We're going to need to continue to recruit a different kind of kid."
In essence, having bigger guys on defense can actually shrink the field – and that's what all defensive coordinators want to accomplish - especially now the way offenses can spread people out and identify the weakest areas of a defense to attack. Mitchell says the coaches also have to be able to accurately assess their players to put them into the best situations possible, both fundamentally and schematically.
"We can't go out and trade for anyone and the recruiting draft is over with so we've got to develop the players we have here," Mitchell said.
Of course, their job can become a little bit easier when they've got bigger, agile guys to work with. Yes, you can get by with smaller guys on defense but in order to do so you have to be really good, really smart, really tough and you've also got to come up with some unorthodox schemes to confuse opposing offenses, which is how West Virginia was able to make a living all of those years with undersized guys playing the 3-3 stack.
On the flip side, playing a more conventional defense these days requires taller more athletic type players – and those guys are not always easy to sign.
"With spread offenses if you really study them, a lot of the time the ball is coming right through the B-gap," Patterson said. "People are speed rushing up the line of scrimmage and it just opens up these nice throwing lanes for the quarterbacks, so therefore, we believe in getting bigger, taller ends and then now they've got to try and throw it through a guy who is much taller. It definitely makes it harder for a quarterback to have vision."
Based on the success opposing quarterbacks had against West Virginia's defense last season, the less vision they have the better.
Keith Patterson, Brian Mitchell, West Virginia Mountaineers, WVU, Big 12 Conference football
Big 12 Media Days: Dave Wannstedt
Big 12 Media Days: Karl Jospeh
Men's Basketball: Bahamas Preview
Womens Soccer: Kadeisha Buchanan Press Conference
Big 12 Media Days: Dana Holgorsen
Women's Soccer: Amanda Hill and Mocha


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Address : Hamptons, NY
Website : email@example.com
Phone : 1 631 831 2140
All Terrain Builders is a custom home building and remodeling company specializing in building the most energy efficient, green, sustainable, comfortable, durable homes built today. Your home should reflect your unique style, whether it be modern, traditional or a combination of both such as a new modern farmhouse that fits in with traditional village exteriors while welcoming owners into a very sleek and modern interior with the finest amenities and home automation technologies, delivering a home of distinctive contrast and charm.
Our homes will save you on average over 50% on energy costs to heat and cool your home, reduce waste by up to 80%, reduce time to complete by over 50% to just 6 months from start of the construction process in many cases, reduce Greenhouse gases by up to 75%, be built with the highest quality, all at the most affordable prices. Our homes on average range from $250 per square foot to $400 per square foot, while most of our competition is priced much higher with a much longer process to get you in your home.
Our homes will also provide you with the healthiest indoor air quality, will be designed and built to last centuries not decades, will incorporate your distinctive design details, will have the highest comfort and value and will have minimal maintenance and repair costs over time.
Our homes can reduce overall energy consumption by more than 50%, save thousands of gallons of water per year and provide superior indoor air quality when compared to a typical code-built house all without the need for renewable energy sources (solar panels, wind turbines, geothermal systems). Our homes are able to achieve the highest levels of certification by utilizing a proprietary "whole-systems approach" to home construction. Well thought out design, a strong project team, world class brand partners and various construction techniques are all integral to the building process.
All Terrain Custom Green Building Group is a member of the National Association of Home Builders, Long Island Builders Institute, NYS Builders Association, and Gary Brown is a NAHB Certified Green Professional Builder with certifications in OSHA and Storm Water Pollution.
Place Categories: Construction Builders, Home Services and Services.


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Things to see and do - Milazzo
Leaving for Italy
Nearby Restaurants
Il Bagatto
Cotation :
Type de cuisine : regional
Doppio Gusto
Cotation :
Type de cuisine : fish and seafood
Hotel San Michele
Cotation :
Type de cuisine : classic
Nearby hotels
Petit Hotel from50 €Book
Hotel California from34 €Book
Hotel Medici from50 €Book
Il Bagatto :
Nearby tourist sites
Il Bagatto
Il Bagatto
- Address :
- via M. Regis 11 I - 98057 Milazzo98057Milazzo
- Phone :
- 0909224212
- E-mail :
- firstname.lastname@example.com
- Website :
- http://www.locandadelbagatto.com
Cuisine regional
Menu: 30€/ 45€ - Carte: 31€/43€
Hosting live music performances once a week, this rustic restaurant specialises in regional cuisine while also serving niche ingredients from other parts of Italy. The contemporary-style guestrooms are in contrast to the more traditional decor in the dining room.
Useful Information
Main services
- Meals served in garden or on terrace
- No dogs allowed
- Air conditioning
- Private dining rooms
- Reserved for non-smokers in all or part of the establishment
Payment options
- American express
- Visa
- Master card
Opening hours :
Closing: 01 february - 15 february. Contact the establishment to check this information.. Contacter l'établissement pour confirmer ces informations.


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The New School >
Eugene Lang College > Academics > Areas of Study > Politics > Curriculum
Supporting Lang
Contact Admission
The Politics major has a four-tier structure. Each tier marks a distinct level of engagement with political concepts, processes, and institutions. After acquiring content knowledge and methodological skills at the lower levels,
students progress to the upper levels and continue to develop their own perspectives on politics.
Thirteen courses are required for successful completion of the Politics major. Distributions and prerequisites for these courses are outlined in the table below, followed by a list of courses meeting the requirements under each tier of study. For updated course listings that meet these requirements, email firstname.lastname@example.com.
Students must take one course in three of the following four subfields:*
U.S. Politics, which
focuses on the politics of the United States and the Americas in domestic and
global context. Courses includeLPOL 2015 Constitutional LawLPOL 2018 Gender, Family, State in American PoliticsLPOL 2120 Power and Politics in the U.S.
Comparative Politics,
which examines the politics of one or more countries or alternate units of
analysis through a comparative lens. Courses includeLPOL 2017 The Nation-State and Its DiscontentsLPOL 2031 Power and the StateLPOL 2501 The Nation-State Is Dead. Long Live the
International Relations and Global Politics, which focuses on relations between countries and the
increasing ambiguity of the nation-state as a pertinent unit of analysis.
Courses includeLPOL 2019 Everybody Wants to Rule the WorldLPOL 2033 Politics of GlobalizationLPOL 2806 Conflict and Inequality in International
Political Theory, which
examines normative, conceptual, analytic, and diagnostic questions through the
lens of political thinkers from ancient through contemporary times. Courses
includeLPOL 2016 Imagining the Good SocietyLPOL 2023 Introduction to Political Theory: Reframing the
PoliticalLPOL 2500 Critiques of Domination
*One core course requirement can be fulfilled
with a ULEC course or Freshman Seminar taught by a Politics professor. At least
two core courses must be LPOL 2000-level courses (or transfer equivalent).
This tier allows students to draw on relevant coursework in economics, history, anthropology, sociology, philosophy, psychology, humanities, and the arts to develop their knowledge of politics and power. It also invites students to put into practice their knowledge of politics by doing an internship or taking a civic engagement or study abroad course.
Students must take three courses from an approved list of non-LPOL classes. At least one of these courses must be an internship, study abroad experience, or civic engagement course.
Sample 2013-2014 courses fulfilling the interdisciplinary requirement (email firstname.lastname@example.com for updated lists by semester):
LANT 2815 The Politics of GivingLCST 3782 Feminist and Queer Affect StudiesLECO 3011 Poverty and InequalityLEDU 3101 Refugees, Immigrants, and EducationLHIS 2844/2854 History, Authority, and PowerLINA 3150 Organizing for Freedom: Community Mobilizing
Through Art and EducationLMUS 3104 How Race Defines American MusicLREL 3069 Buddhism and Human RightsLSOC 3095 "The Ghetto"LURB 3040 Social Justice and the CityUENV 4520 Urban Food SystemsUGLB 2110 [Dis]order and [In]justice
Students can take any six LPOL classes at the 3000 and 4000 levels.
Students must complete two core classes (one in the relevant subfield) or
attain junior or senior status to enroll. Sample courses:
LPOL 3007 Contesting Economic InequalityLPOL 3011 Studying Power Through FieldworkLPOL 3016 Borders and WallsLPOL 3029 Biodiversity and PoliticsLPOL 3033 Utopia and UrbanismLPOL 3038 China in Revolution and ReformLPOL 3041 Resistance
In the fourth and final tier, students choose between writing an individual honors thesis and joining a senior capstone seminar.
The honors thesis is written under the direct supervision of a Department of Politics faculty member and provides students with valuable experience conceptualizing, researching, writing, and presenting an original scholarly work in politics. The honors thesis is researched and written over the course of an academic year; upon completion, students develop and deliver a public presentation of their findings in a suitable academic forum. Students electing to write an honors thesis must meet minimum GPA requirements and receive approval from a supervising faculty member.
The capstone seminar offers students an opportunity to produce original work that may include research, political intervention, education, or institution building. Reflecting on the political knowledge acquired in previous courses, students (either individually or collaboratively) design a unique project. The shape and substance of the project will vary depending on the year and the instructor. Examples include
Undergraduate students from any college in the university who are not
majoring in Liberal Arts can elect to minor in Politics. Five courses are required for
successful completion of this minor:
Students pursuing a Bachelor of Arts or Bachelor of Science in Liberal Arts cannot elect an academic minor; however, they can pursue deeper study in this subject area through the self-designed major. To explore this option, contact an academic advisor and read more about the self-designed option at Lang.


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BlogHer Day One – Thursday Recap
You GUYS. I'm in New York! So, here's what's happened so far…uneventful plane rides except for the condensation rolling across the ceiling of the plane from Detroit to LaGuardia, I took a video with my camera but haven't uploaded it yet. It was like when you open your freezer and that mist rolls out? Once we got up in the air it went away but it was still weird.
Oh, and of course when I landed at Detroit from Lansing I was at one end of C terminal, and my flight to LaGuardia was at the completely opposite end of A terminal, so I had a bit of a hike to get there. But it was all good.
The guy who picked me up from the airport was from Michigan, what are the odds, and he was so great. His name is Tom Rhoades, and he's an actor who works for this car service that hires new actors on purpose so they can drive established actors back and forth from the airport and make industry contacts. He got a job working for Angela Lansbury because he picked her up from the airport!
I cannot believe how many people there are, how many cars, how many taxis. Every street is jam packed!
My hotel is on the corner of 53rd Street and 6th Avenue. I met up with Dawn as soon as I arrived and we were both starving so we set out to find something to eat. We only had to go right across the street! We ate lunch at this gyro stand yesterday, it's one of the most popular stands in the city, only $5.50 for this HUGE gyro. I don't like lamb so I had chicken that he was grilling right there with onions and peppers, in a warm fluffy pita bread with tzatziki sauce. SO GOOD. After work people line up for an hour to eat there. And there's a fountain across the street that looks like the head of a dandelion, it's so cool.
I met Dre from Click Communications, she's the one that sends me all the great Disney DVDs to review. It was great to finally meet her! After standing outside for 45 minutes though, I'd had enough of 92 degree heat and humidity so I headed back in and up to my room to freshen up for my Bumble Bee Foods Bee Squad event.
Our event went so well! Chef Scott made three fantastic appetizers, I'll post the recipes on MomCooks when I get home. There was also delicious meats and cheeses, vegetables, and a dessert tray. We had a great turnout of people, too! I wore black wedge sandals and by the time it was over my feet were KILLING me. I was so glad we had a shuttle bus!
From there I came back to the room and collapsed. I turned out the light, put my head on the pillow, and next thing I knew it was morning. Oh yes, and I grabbed the WRONG USB cable for my camera, so I can't upload any photos! I have my camera set on a smaller photo size so I can take more pictures, but unless I sit near someone with an external card reader, I won't be able to upload anything until Sunday night
Next up, Friday Recap!
- Wordless Wednesday – The Dress I'm Wearing Friday Night (First Dress in 12 Years!)
- BlogHer Recap – Yep, This Really Is Where I Belong


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A chic alternative a plain loom bracelet. You can either leave it plain with a chain or add a charm.
Step 2: You'll need
You'll need a rubber band loom (they make them everywhere!)
3" of large chain Bands in the colors you like
"C" clips for a closure (they come with the loom)
Step 3:
With the loom facing away from you, count down 11 pegs from the top of the loom on the left row of pegs.
Stretch 2 bands between peg 1 & 2. Next, two bands between 2 & 3. Continue to the the 10th peg.
Thread two bands between the end link on your chain and then stretch it over the 10th and 11th peg.
Repeat this process on the right hand row of pegs. You will not be putting bands on the center row.
Thread 2 bands between the other end link on your chain and thread it through the 10th and 11th peg.
Step 4:
Flip your loom around and with your hook, grab the 2 bands on the 11th peg and stretch them around the end link and on to the 10th peg.
Now with your hook, reach through the peg, grab the 2 bands on the 10th peg and loop them on the 9th peg, this will start creating a chain.
Do this on both sides.
Step 5:
Grab a "C" clip, carefully remove the last band on one side and attach it to the last band.
Place your hook through the last band on the other side and remove the bracelet and then add the bands to the "C" clip to finish it.
where did u get the gold chains from????
I actually love this! I haven't really been jumping on the rainbow loom trend, but this might just get me started!
I like the black bands the best for guys. I made one with a big link and all black bands and it looks great.
Yeah, they look really cool! I like this "grown up" version of rainbow looming. I think I'm going to pick up a loom of my own and try it out.
I made my own version of this and gave it as a gift at Burning Man! Instructable coming soon :)


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From Charlesbridge Publishing:
April is Poetry Month
One day I took a chance and wrote a poem.
It fel t so great to let my words run free.
Now I write outside, in school, at home —
And all my work is always signed "By Me.â€
In honor of National Poetry Month, Charlesbridge invites students
in fourth through sixth grade to take a chance and enter a poem
into the I Must Go Down to the Beach Again poetry contest.
Put your own twist on a Shakespearean sonnet, or write an original
funny haiku. Winning poems will capture the imagination and
tickle the funny bone. For inspiration, read I Must Go Down to the
Beach Again (and Other Poems), by Karen Jo Shapiro and
illustrated by Judy Love.
The first-place winner receives a $100 gift certificate to their local independent bookstore, a
subscription to Stone Soup Magazine, and an autographed copy of I Must Go Down to the Beach Again.
Second- and third-place winners receive a subscription to Stone Soup Magazine and an autographed
copy of I Must Go Down to the Beach Again. All entries will be published on Charlesbridge's website.
Poems can be any length, typed or hand-written (legibility counts). Participants must be fourth through
sixth grade elementary students. Deadline for submission is April 30, 2007. Winners will be notified
by May 15, 2007.
Email your submissions to firstname.lastname@example.com, or send them by
snail mail to:
Charlesbridge Publishing
I Must Go Down to the Beach Again Poetry Contest
85 Main Street, Watertown, MA 02472
No purchase necessary. Contest is open to students in the United States only.
Submissions will not be returned. Submission authorizes Charlesbridge to reprint the
poem in part or whole. Charlesbridge employees and their families are not
eligible for participation.


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Philly Bloke Supports Local Artists
Brian Reinert is a young emerging artist born and raised in the suburbs of Philadelphia, Pennsylvania. From childhood, Brian has always had an interest and appreciation in all forms of art and officially began his artistic career in 2009. Being self-taught, Brian pulls his inspirations from artists like Jackson Pollock and Andy Warhol.
Brian likes to consider himself to be somewhat like Bruce Wayne. During the day he can be found in a suit and tie working in the executive recruiting field, but at night he can be found in his "bat cave" creating his next work of art and saving the boring white walls of the world.
Brian's paintings can be found in homes and businesses throughout the East Coast and beyond from Boston, to Pittsburgh, Washington DC, to Houston, and even the Netherlands!
Philly Bloke supports Movember
During November each year, Movember is responsible for the sprouting of mustaches on thousands of men's faces, in the US and around the world. With their Mo's, these men raise vital awareness and funds for men's health issues, specifically prostate and testicular cancer initiatives.
Check us out on NBC Philadelphia
Philly Bloke supports The Autism Society
The Autism Society improves the lives of all affected by autism through education, advocacy, services, research and support.


text:
|Product description
オクタニ / American casual / pretty / unisex / miscellaneous goods / mail order
Sneakers socks ☆ the popular "GRATEFUL DEAD BEAR." in stock!
Elasticity in 23 cm-26 cm up from in a couple ペアソックス Cha!
But many say this price! Also bought a 5 foot 1000 yen.
Cute design let you stock up ↑
■ size: approx. 23-26 cm
|For more images
Start Date:01/08/2015 00:00 JST
End Date:31/08/2015 23:59 JST
This product cannot be shipped to United States from the store.
Please contact the store for further information.


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San Antonio police: Man pays car bill with stolen money order
SAPD: Mark Moreno, 25, captured on surveillance video and charged with forgery
A Southeast Side man, Mark Moreno, 25, is accused of stealing a money order from a drop box at an auto loan business and using it to pay his own car note.
The case came to light after another customer received a call from Auto Account Service in January, telling him that his auto loan payment was overdue, according to an arrest warrant affidavit.
The man told the caller that he had made his payment a few days prior by way of a drop box at the business, the affidavit stated.
San Antonio police said they later learned that Moreno was captured on surveillance video, approaching the drop box soon after the other man had made his payment, the affidavit stated.
They said they also found out the signature on the man's money order had been altered, and that the money order was used toward a payment on Moreno's auto loan.
Moreno was arrested Tuesday on a charge of forgery.
For a list of recent stories Katrina Webber has done, click here.
Copyright 2013 by KSAT.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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