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At Penn Medicine, patients with small intestine cancer receive their care from a multidisciplinary team of nationally recognized experts in the diagnosis, treatment and research of gastrointestinal cancer.
Also known as the small bowel, the small intestine is the portion of the digestive tract that connects the stomach with the large bowl, or colon. The small intestine is critical in the breakdown and absorption of food so the body can absorb nutrients.
The small intestine can be divided into three areas:
Cancer of the small intestine is rare. There are five main types of intestinal cancer, differentiated by their appearance under a microscope:
Penn Medicine's multidisciplinary approach to cancer diagnosis and treatment provides better outcomes and gives patients access to the most advanced treatment, surgical techniques and clinical trials.
Because navigating a cancer diagnosis and treatment options can be difficult, patients who wish to connect with a cancer specialist at Penn Medicine can speak with a cancer nurse, who can help them make an appointment with the right physician.
To connect with a cancer nurse at Penn Medicine, patients should call 800-789-PENN.
An accurate cancer diagnosis from trusted cancer specialists is the first step in getting personalized treatment options to treat small intestine cancer.
Patients who choose Penn's Abramson Cancer Center, benefit from a multidisciplinary team of cancer specialists including gastroenterologists, radiologists, pathologists and surgeons who work together to provide a diagnosis and treatment plan custom designed for each patient with small intestine cancer.
Cancer specialists at Penn Medicine are highly experienced in using the most advanced techniques for diagnosing small intestine cancer and are actively researching better and more precise ways to detect small intestine cancer.
Because an accurate diagnosis is a critical step in planning cancer treatment, it's important patients know that when they come to Penn Medicine's Abramson Cancer Center, they are taking an important step in getting the best cancer treatment.
Navigating a cancer diagnosis and treatment options can be difficult, patients who wish to connect with a cancer specialist at Penn Medicine can speak with a cancer nurse, who can help them make an appointment with the right person. Penn Medicine's contact center has experienced cancer nurses available and ready to guide patients in finding the cancer specialist right for them.
To connect with a cancer nurse at Penn Medicine, patients should call 800-789-PENN.
Following the diagnosis and staging of small intestine cancer, cancer specialists at Penn's Abramson Cancer Center develop a personalized treatment plan. Penn's treatment options for small intestine cancer include:
Because navigating a cancer diagnosis and treatment options can be difficult, patients who wish to connect with a cancer specialist at Penn Medicine can speak with a cancer nurse, who can help them make an appointment with the right physician.
To connect with a cancer nurse at Penn Medicine, patients should call 800-789-PENN.
Surgery is the most common treatment for intestinal cancer.
When the tumor is resectable, radical surgery offers the best chance for cure.
Resection is surgery that removes all or part of an organ that contains cancer. Resection surgery may include the small intestine and nearby organs if the cancer has spread. Surgeons may remove the section of the small intestine that contains the cancer and join the cut ends of the small intestine together. This procedure is called an anastomosis. Surgeons may also remove affected lymph nodes during the procedure.
When the tumor cannot be completely resected, a surgical bypass can relieve symptoms. This procedure reroutes the small intestine, allowing food to go around a tumor that cannot be removed.
Radiation oncologists at Penn Medicine are recognized for techniques that target radiation precisely to the disease site while sparing nearby tissue.
Proton therapy at Penn Medicine is now being used to treat upper gastrointestinal cancers and recurrent tumors in the digestive tract. Penn Medicine is one of the only facilities in the country treating gastrointestinal cancers in this way.
Radiation therapy uses high-energy radiation to kill cancer cells. A radiation therapy schedule usually consists of a specific number of treatments given over an extended period of time. In many cases, radiation therapy is capable of killing all of the cancer cells.
The imaging technology used by radiation oncologists at Penn Medicine helps shape the radiation treatment beam to the shape of the tumor. Known as conformal radiation therapy, this technology gives doctors more control when treating tumors.
In conformal radiation, a special computer uses CT imaging scans to create 3-D maps of the location of the cancer in the body. The system permits the delivery of radiation from several directions, and the beams can then be shaped, or conformed, to match the shape of the cancer. Conformal radiation therapy limits radiation exposure to nearby healthy tissue as well as the tissue in the beam's path.
As national leaders in radiation therapy, radiation oncologists at Penn Medicine are experts in the use of the latest therapies, including intensity-modulated radiation therapy (IMRT), to treat cancer.
This advanced type of radiotherapy uses a computer-controlled device, called a linear accelerator, to deliver precise doses of radiation to tumors or specific areas within the tumors. Radiation therapy, including IMRT, stops cancer cells from dividing and growing, thus killing the cancer cells and preventing tumor growth.
In many cases, radiation therapy is capable of killing all of the cancer cells. Using 3-D computed tomography (CT) images of the patient along with computerized dose calculations, IMRT allows for the radiation dose to conform more precisely to the three-dimensional shape of the tumor by controlling; or modulating; the intensity of the radiation beam. The therapy allows higher radiation doses to be delivered to regions within the tumor while minimizing the dose to the surrounding area.
Penn Medicine is the only academic medical center in the country that is using proton therapy to treat recurrent gastrointestinal tumors in clinical trials. Also, radiation oncologists at Penn Medicine will soon use proton therapy to treat gastrointestinal cancers in the upper digestive tract.
Penn Medicine's Roberts Proton Therapy Center is the largest and most advanced facility in the world for this precise form of cancer radiation. Patients have access to one of the most sophisticated weapons against cancer, seamlessly integrated with the full range of oncology services available at Penn Medicine. Proton therapy is external beam radiotherapy in which protons are directed at a tumor.
The radiation dose that is given through protons is very precise, and limits the exposure of normal tissues. This allows the radiation dose delivered to the tumor to be increased beyond conventional radiation. The result is a better chance for curing cancer with fewer harmful side effects.
Proton therapy, like all forms of radiation therapy, works by aiming the energized particles, in this case protons, onto the target tumor. The particles damage the DNA of cells, ultimately causing their death. Unlike X-rays, protons can be manipulated to release most of their energy only when they reach their target. With more energy reaching the cancerous cells, more damage is administered by each burst of radiation.
Volumetric-modulated arc therapy (VMAT) is a type of specialized intensity modulated radiation therapy, or IMRT. VMAT delivers radiation by rotating the radiation machine, through one or more arcs while radiation is continuously delivered.
VMAT allows Penn radiation oncologists to treat complex cancers while minimizing exposure to surrounding healthy tissue. VMAT shortens radiation delivery time, and offers patient more comfort because it does not require patients to lie completely still for long periods of time.
Penn radiation oncologists use RapidArc™ radiotherapy technology to treat hard to reach tumors.
Penn Medicine specializes in a team approach to treatment with interdisciplinary care and innovative approaches that use chemotherapy to target tumors prior to surgery.
Chemotherapy uses drugs to kill cancer cells. It is delivered through an intravenous catheter or a pill and targets cancer cells throughout the body. Depending on the stage of the tumor, chemotherapy may be given after surgery or in combination with radiation therapy.
Today, more and more people are surviving cancer. Clinical trials, many of which are conducted at Penn Medicine benefit patients through breakthrough therapies and treatments. These new advances in cancer treatment are occurring every day, giving patients hope that even greater discoveries lie ahead. Through clinical trials:
Biologic therapy, also called targeted therapy, uses the patients' own immune system to target cancer cells. Substances made by the body or in a laboratory are used to boost, direct or restore the body's natural defenses against cancer, and are delivered orally by pill or intravenously. This type of cancer treatment is also called immunotherapy.
Radiation therapy with radiosensitizers is currently being studied in clinical trials. Radiosensitizers are drugs that make tumor cells more sensitive to radiation therapy. Combining radiation therapy with radiosensitizers may kill more tumor cells.
If the tumor is blocking the duodenum, a stent may be placed to bypass the blockage.
In addition to standard treatments and clinical trials, patients at Penn Medicine may wish to add additional therapies and treatments such as massage therapy, acupuncture and art therapy. These therapies do not have curative intent, and are designed to complement standard treatments, not take their place.
At Penn Medicine, integrative medicine and wellness services can supplement traditional cancer treatments such as chemotherapy, surgery and radiation therapy. While conventional medicine plays a critical role in eradicating cancer, integrative medicine and wellness programs offer patients and their families ways to enhance the quality of their lives, minimize or reduce the side effects of cancer and cancer treatment, and promote healing and recovery.
Cancer specialists at Penn Medicine are knowledgeable and supportive of complementary cancer treatments. The cancer team works with patients and families to integrate these supportive programs into the overall care plan, while ensuring the safety and health of patients.
The Abramson Cancer Center's range of integrative supportive services is designed to help patients cope with the cancer experience and improve their overall sense of well-being. Services include:
The Abramson Cancer Center at Pennsylvania Hospital at Pennsylvania Hospital offers a variety of supportive care programs for patients and families, from diagnosis through survivorship. These programs are available at no cost to the patients treated at Pennsylvania Hospital, and some are open to patients treated elsewhere. These services include social work counseling, nutrition counseling, psychological counseling and spiritual counseling.
The Cancer Appetite and Rehabilitation Clinic focuses on patients with loss of appetite and weight.
The Supportive Care Clinic helps to manage cancer related symptoms. Integrative support programs include:
Support groups and educational programs are available at Pennsylvania Hospital throughout the year.
Palliative care provides medical and non-medical interventions to ease the symptoms of cancer and its treatment. Palliative care includes physical, emotional and spiritual care that can enhance the quality of life for cancer patients.
Palliative care can be used to complement traditional cancer therapies, or to and improve quality of life when curative therapies are no longer an option.
Palliative care is an approach to patient care that can be integrated with curative therapies at any point from diagnosis to survivorship or end-of-life care.
Palliative care services include palliative chemotherapy, radiation therapy and surgery as well as psychological counseling, art therapy and support groups for patients and families. The goals of palliative care are to enhance the quality of life for cancer patients and their families, and provide emotional and spiritual support to enhance personal growth.
Palliative care services are offered at Pennsylvania Hospital, and at the Hospital of the University of Pennsylvania.
Penn Home Care and Hospice Services offer a full range of home health care needs by partnering three top-level home health care services under one roof:
Penn Home Care and Hospice Services offer an array of specialized therapies and medications for patients with cancer and cancer-related conditions.
Every step of cancer treatment; from a cancer diagnosis, to surgery and treatment to forming a survivorship plan; comes with different needs and issues that should be addressed.
Oncology Navigation Specialists at the Abramson Cancer Center are available to make a patient's experience as seamless as possible. As experts in navigating complex health care situations, patient support specialists serve as a consistent point of contact and a reliable source for advice, support and direction for patients and families. They can help in a variety of ways including; provide emotional support, identify resources, and ensure access to information, support services, educational programs and community resources.
Learn more about Patient Navigation specialists at the Abramson Cancer Center.
Survivorship programs at Penn Medicine are a distinct phase of intestinal cancer care and are designed to help patients' transition from their cancer treatment routine to a post-cancer care lifestyle. There are more than 12 million cancer survivors living and thriving today as a result of advances in cancer treatment. However, cancer treatments can result in physical, emotional and financial complications long after the therapy is complete.
Peter O'Dwyer, MD, professor of Hematology-Oncology and program director of Development Therapeutics in the Abramson Cancer Center, was interviewed on NBC10's 10! Show about Penn's work as part of the Stand Up to Cancer Dream Team... Read more


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A Baltimore County shopping center was evacuated after high levels of carbon monoxide were detected nearby, officials said.
The call came in around 3:30 p.m. Friday at the Dollar General Store at the Logan Village Shopping Center on Dundalk Avenue.
Officials said the gas may be coming from a sewer or basement in the shopping center where crews detected high levels of carbon monoxide in the parking lot.
No one was reported injured or taken to any hospital.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus

subset: commoncrawl


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Insider lockup expirations are like alcohol. A few whiskeys won't change your personality, only intensify it and bring it to the surface, whether that personality is a weepy, huggy "I love you" guy or an angry bar brawler.
What does that mean for Twitter, whose shares are down double digits today — for the second time in a week — following the expiration of a lockup affecting 82% of the company's outstanding shares? Only this: That you shouldn't read too much into it. The crisis of confidence around Twitter is real, but it has less to do with what insiders think than with what we already know.
In August 2012, Facebook shares plunged under $20 for the first time as a tranche of 270 million insider shares came onto the market. Three months later, an even bigger block of shares freed up — but this time, the result was a 13% jump in price.
What explained the difference? In between, in the third quarter, Facebook launched its mobile app install ads, the product that would eventually account for more than half of its mobile revenue, and likely more than a third of its total revenue (at least according to one knowledgeable source). Facebook started the third quarter with barely any revenue from mobile; by the time it issued earnings in October, it was able to report that 14% of its revenue was coming from phones and tablets. Once the cloud of concern around mobile monetization lifted, Facebook shares never looked back.
For Twitter, the issue isn't monetization; it's users. When its stock tumbled last week, it was because the company had to report that, for yet another quarter, user growth was anemic, and the trend in user engagement was equivocal, requiring some parsing of definitions to claim progress.
Nothing of substance has changed in the intervening six days. The insiders who announced they wouldn't unload any shares after the lockup ended — a group that includes CEO Dick Costolo, co-founders Ev Williams and Jack Dorsey, and investors like Chris Sacca and Rizvi Traverse — haven't. Today's sell-off isn't about information; it's about momentum.
Of course, none of this means that Twitter will follow the path of Facebook and rebound off the floor in time for its next earnings report. For that to happen, it will have add substantially more than the 14 million new users who signed up in Q1, or succeed in redefining growth such that it's not about monthly active users but about total audience or some other metric. Even that might not be enough. It's not hard to find investors who think Twitter is still considerably overvalued. "Twenty billion dollars of market cap for an under 10-year-old business that hasn't shown a history of profits is not a particularly reasonable stock," says Mitch Rubin of RiverPark Funds, which is short Twitter.
But whatever you thought of Twitter's prospects yesterday, they're no different today.


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ID/Damiana N. Simanjuntak
Earnings from sales of locally produced electronic items surged 11 percent in the first four months of 2012 compared to a year earlier, while the promise of even higher growth is fueling a rush by manufacturers to boost their production in Indonesia.
Yeane Keet, the deputy secretary general of the Indonesian Electronics Association (Gabel), said on Sunday that sales of electronic items from January through April amounted to Rp 8.11 trillion ($860 million), compared to Rp 7.3 trillion in the same period last year.
He said television sets accounted for nearly half, or 46 percent, of the total sales amount, followed by refrigerators (22 percent), air conditioners (16 percent) and washing machines (13 percent).
Gabel chairman Ali Soebroto Oentaryo had previously said that although sales of individual appliances dipped slightly in April and May, sales across the year would be higher.
Alam Surjaputra, the Gabel general chairman and director of appliance producer Star Cosmos, predicted sales for 2012 would be 5 percent to 7 percent higher than for last year.
But Yeane said there was potential for even higher growth. "Annual growth can potentially exceed 20 percent. That's because domestically produced electronic items are still very competitive against imported products," he said.
Alam confirmed that Star Cosmos was seeking to tap into that growth potential by expanding its production capacity.
"We will definitely keep strengthening our business in the consumer electronics segment," he said.
Toshiba Consumer Products Indonesia, the local principal of the Japanese appliance manufacturer, also plans to boost its production capacity in the country, particularly for television sets.
"As of July, we expect to increase our production of TV sets to five million units a year," said Adri Nursalim, a manager at Toshiba's factory planning department.
Yuzo Tsuchiya, the TCPI president director, said the increased production was also meant to fulfill export demand.
"With this increased capacity, we hope that Toshiba's factory in Indonesia can be the supply base for the Asean [Association of Southeast Asian Nations] market," he said.
Sharp Electronics Indonesia is also looking to expand its base in the country, with a planned Rp 1.2 trillion investment for a new factory in Karawang, West Java, to be constructed from next month.
The factory is expected to produce 220,000 refrigerators and 140,000 washing machines a month, two and a half times the production capacity of Sharp's current factory in Pulo Gadung, East Jakarta.


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A draft FAA study into the relationship of pilots with today's airliner flightdecks – specifically the automated systems in the cockpits - provides the hard data to prove that pilots are not properly trained for modern cockpits. The result has been serious accidents that did not need to happen.
I have been arguing for ages that airline pilot recurrent training needs a serious review. Now, courtesy of Dr Kathy Abbott's FAA team, it looks as if it might get one. This is good news.
At the same event - last week's Flight Safety Foundation International Aviation Safety Seminar in Milan, Italy – at which Abbott outlined the initial results of her studies, three seriously big industry guns spoke at length on stall recovery, and one of similar calibre presented on go-arounds. Stall recovery was addressed by Boeing's Dave Carbaugh, Airbus's Claude LeLaie, and ALPA's top human factors expert Capt David McKenney. Air France corporate safety manager Bertrand de Courville addressed the art of safe go-arounds.
These are two subjects so fundamental to basic pilot competence that the need to cover them in such detail is a symptom of the fact that current training is not addressing the basics. And Abbott, of course, has now revealed that today's training is not covering advanced automation either.
So what is recurrent airline training achieving, then? It's a bit of an oversimplification of the many things she said, but the hard evidence suggests that pilots concentrate on programming the automation at the expense of monitoring the flight path.
Is anyone actually surprised by this? Hadn't you actually observed it yourself? Hasn't there been sufficient anecdotal evidence of this for a while to make you worried? Well now Abbott's team is on hand to provide the data to back up the anecdotes.
Don't expect change tomorrow, but big changes will come. They must come.


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Any Ultimate Chicken Popcorn Recipe?
@jedd63, thanks man
@lapsangsouchong, scaramoche
Nice idea for general tso's, but i don't expect to have any alcohol content in my batter. Actually I had tried Chef John recipe from Allrecipes, he substitute water with soda but I thought that we don't need to use soda anymore since we use baking powder instead.
Kenji had posts something about double frying chicken right? and I think that idea is great for freezing and finish with the second deep frying.
How do your trick works? Enlight me your majesty!
Anyway thanks guys for your input, it helps my brainstorming a lot


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Texas school districts and parents are headed back to the courthouse in another effort to get more equitable funding for public schools.
A coalition representing public school districts, taxpayers and parents filed a lawsuit against the state in Travis County district court Monday. The Texas Taxpayer & Student Fairness Coalition claims the state's public school finance system is unconstitutional because it does not treat Texas taxpayers and schoolchildren fairly.
Taxpayers in 546 school districts could impose the maximum $1.17 tax rate to support their local schools and not come close to generating the same revenue that wealthier school districts get at a $1.04 rate, according to the suit. For example, Fort Worth and Austin independent school districts have roughly the same number of students, but the Austin district gets about $100 million more a year than Fort Worth, even with identical tax rates.
"It's not equitable. It's not fair. It's just crazy," said Austin lawyer Rick Gray, lead lawyer for the plaintiffs, which include 150 school districts. He said he expects many districts, taxpayers, parents and business owners to join the litigation.
Several Houston-area school districts are planning to join a separate lawsuit in coming weeks. Trustees of the Fort Bend Independent School District were the first large district in the area to confirm their intent, voting Monday to authorize a legal challenge against the state's school funding system. Members of the Houston ISD board are planning to discuss possible legal options Thursday, according to a spokesman.


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New dom of the house Jaxton Wheeler awaits on his throne as his sub Jett Jax crawls in on his hands and knees, ready to serve. He removes his master's leather jock and swallows the huge cock that awaits him before he's relentlessly beaten with the crop. His cock locked in chastity, Jett is made to swallow Jaxton's huge cock until he's flogged from front to back. Suspended in the air, Jett opens his hole for a vigorous fuck until Jaxton brings him to the ground. After a final fuck, Jaxton rewards his sub with a face full of cum and has him lick up every drop.
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anyone know anything about the Designer Guys new show that's coming? Curiousity is killing me...;)
that's exactly what I thought was happening- so what is the format you guys are doing MIchael?
they are advertising on hgtv that they have a new show coming- something different than the "Designer Guy's" but they aren't saying much else...I was hoping someone here had heard something.
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When I do part one...bootmii freezes. I'm using a 4.3u.What is wrong?
after the step where i install the homebrew channel and bootmii and my screen turn black and im trying to get the file from media file but the link is dead, anyone have an alternative link?
When I do part one...bootmii freezes. I'm using a 4.3u.What is wrong?
@ daaave.le
Last edited by narse1979; 10-02-2010 at 01:08 PM.
i think thats what my system is doing... it freezes and have the black screen... and my wii disc tray is blinking blue
hey narse thanks for the help bro, it worked so far im in the process of the nand backup, appreciated!
Okay,heres the deal.Im using this guide------> http://www.wiihacks.com/recommended-...d-any-wii.html And now when Im at chapter 2 part one...bootmii wont load.What do I do?
i am running 4.3 system menu and i can successfully run usb loader and play games. I put a burnt game into game slot, it loads but it is in black and white also, but the screen is scrolling fast.. is there a way to fix this
Generic Wii Patcher - GBAtemp.net
Ipsa scientia potestas est.
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August 1, 2015
Government officials and over one hundred community members gathered Saturday for the Navasota Municipal Airport Expansion ribbon cutting ceremony.
The ceremony celebrated the expansion of the airport to a size of 5,000 feet in length and 75 feet in width via assistance from a TXDOT grant and a land donation by Bob Waltrip. The new expansion reportedly allows jet traffic at the airport.
The event featured a B-25 Mitchell Bomber on display courtesy of the Lone Star Flight Museum of Galveston, Texas.
Among those in attendance were Congressmen Bill Flores and Kevin Brady, State Rep. Lois Kolkhorst, as well as city and county officials.
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First Bankers does more than just lend money for fire trucks.
Our related companies help fire departments by consulting, advising, teaching, and publishing a lot of information about the financial issues facing fire departments.
Most of the information is FREE.
You can learn more about our related companies by visiting:
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Be a smart TV drug ad watcher
For 16 hours a year (nine times a day for the average viewer) friendly voices come through the TV promising that a brand-name medicine can cure what ails you. That's the estimated onslaught of direct-to-consumer pharmaceutical advertising on U.S. television. (In Canada, ads can mention either the brand or the indication, but not both.)
Now a new report sounds a consumer alert: While 43 percent of Rx ad claims are objectively true (for nonprescription medicines it was only 23 percent), 55 percent are potentially misleading and 2 percent are false. So how can you get the benefits you need from medications without falling for the hype? Here are three tips.
1. When drug ads come on TV, be skeptical. Ask yourself why it is always rugged men driving big trucks who have ED? And why is it always dreamy-eyed women who look like they could spin their own wool who are fighting depression? If you take a second look, you'll be able to differentiate between the pitch and the substance.
2. Before you ask your doc for a medication you've seen on TV, or whenever you get a new prescription, read the prescribing information (it's on the website and in the package). You'll discover usage; warning and precautions; info on clinical studies; and much more.
3. Then ask your doctor how the med will affect YOU; what's the goal and the risk of taking it; and are there alternative medications that can achieve the same result?
Together, make an informed decision about what meds you take.
Mehmet Oz, M.D. is host of "The Dr. Oz Show," and Mike Roizen, M.D. is Chief Wellness Officer and Chair of Wellness Institute at Cleveland Clinic. To live your healthiest, tune into "The Dr. Oz Show" or visit www.sharecare.com.
The Herald-Dispatch welcomes your comments on this article, but please be civil. Avoid profanity, obscenity, personal attacks, accusations of criminal activity, name-calling or insults to the other posters. Herald-dispatch.com does not control or monitor comments as they are posted, but if you find a comment offensive or uncivil, hover your mouse over the comment and click the X that appears in the upper right of the comment. If you do not want your comment to post to your personal Facebook page, uncheck the box below the comment.


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Updated: 07/25/2013 10:26 AM KSTP.com By: Jennie Olson
Parents whose children went on a fatal field trip to a St. Paul park say they should have been warned of possible dangers.
Two students from Peter Hobart Elementary School were killed and two others were injured in a landslide at Lilydale Regional Park last May. Parents say a field trip information sheet sent home to parents did not mention the potential for danger. It only said the children should be prepared for hiking, climbing and getting muddy.
Minnesota Public Radio News says St. Louis Park Public Schools said in a statement that the district is trying to move forward while continuing to provide support for those impacted by the event.
Danielle Meldahl's 10-year-old son, Devin, was injured in the landslide. Meldahl says if she had been aware of the danger, she wouldn't have let her son attend.
(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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MECFSForums has closed.
Oh boy. How scary. I'm posting a thread! I found these concerns re the Lipkin study on facebook, and I thought you people should see it too.We all know that an MRV is only detectable by for a short time in the blood following innoculation. Thereafter it is readily found by PCR in lymphoid tissue, notably spleen, lymph nodes, tonsilluar tissue, lung tissue and intestines. We also know that for complex reasons the antibody response fades and also becomes undetectable.This is typical of the behaviour of many other gamma retroviruses. They infect B cells in the lymph nodes first and then spread to other secondary lymphoid tissues. They infect a class of B cell which ultimately resides in the peritoneal cavity. They also infect recycling CD20 B cells because those cells pass through the spleen and a very low percentage of them will become infected.The trouble is that these cells quite literally burst after a few days. Memory B cells are also a target for infection but after a short time in the blood they home in on lymphoid tissues again. The basic message is that multiple samples at multiple time points need to be taken from an infected patient to have any sort of chance of detecting a MRV in blood samples. The Lipkin study involves samples taken from a patient on the same day. We also know that the people have been"trying" to find a MRV in people with ME have set their tests to dectect a synthetic clone which does not exist in nature. Obviously they have no chance of detecting a real MRV in infected patients. They are going to be using this method again in the Lipkin study. Lipkin knows that XMRV (VP62) does not exist in nature so 75% of the researchers will be using tests which have no chance of working. This will leave Dr Mikovits and Dr Ruscetti attempting to detect an MRV in blood samples taken from chronically tired people on the same day. They are both brilliant scientists but contrary to their detractors views there is no evidence that they have magical powers! Even if by some incredible feat of ingenuity they are able to detect some virus in some people the difference between the number of ME positives and the numbers of CONTACT controls is certain to be obscured. Either way we lose. The Lipkin study has an excellent design for governments and corporate interests but a dire design for people with ME.
The science paper found HGRV in blood samples at 67%. Then at 98% using more serology on blood samples. Correct me if I am wrong please.Why is the bar being set at tissue samples all of a sudden and by who?Was the Science paper just a lucky day at the lab? If Alter/Lo and JM/FR have been able to publish positive results from blood already then why not again?I'm all for testing tissue also btw.
I don't think it was written by Gerwyn, but anyway, here's the link: https://www.facebook.com/pages/HMRV-Global-Advocacy/348451488504232I tend to agree with AWOL for what's it worth. A lot of supposition has gone into the above and it is being presented as fait de compli when in fact we know very little about the 'Lipkin Study'.
This would be Gerwyn's analysis. Many interesting points. He does however use Weeselian tactic on certain issues (jumping to unjustified conclusions and pushing them dogmatically as fact). It is important to see this when reading this assessment.1. "chronically tired people" - We have some reports from patients involved in the study that show that a serious effort is being made to assemble a solid cohort. Refering to these patients as chronically tired is insulting to them, and the intention is to set the ground work for denying the study has any value if it fails and if no other more solid scientific flaws can be found other than the vague claim that the patients chosen were not "real ME" patients.
2. I do not know where the information comes from to support the claim that samples will all be taken on the same day, and that repeat sampling will not be done etc. I am not saying this is not true, however a source needs to be provided when making such claims and then attacking the study based on them. It could very well be that Mikovits and Ruscetti, who are involved in the study, have persuaded Lipkin of the importance of multiple draws at different times.
3. While I object at this point as much as Gerwyn does to the stubborn insistence on using vp62 and defining XMRV according to it, I am not sure we have any actual information at all to confirm that 75% or researchers in the study will be doing this, and will continue to display unwillingness to learn from the previous failed studies. On what information is he basing this claim?
4. Where is the actual source that confirms the use of contact controls? I have heard this rumour, but so far not from reliable sources. I would like to see a direct referece made please, Gerwyn and editors.
The patients won't know if they are to be included in this paper or for other research. They may be excluded with the criteria they are using at a later date, unbeknown to the patients.
Many of the clinicians involved routinely use Fukuda. That only requires a person to be tired.
Would it be an attack if they are collecting samples on the same day? And if repeat sampling is not done? Do you agree than that would undermine the study if that they did that?
The CDC has only ever used VP62. Lo now uses his failed VP62 assay. Do you agree then that if their assays are only designed to detect VP62 this undermines the study? How would you describe their use of assays built to detect a synthetic virus?
Again, I am interested to know what you would think if the controls are contact controls? That would mean the rates of infection would be dramatically distorted would it not?
Last month Gerwyn seemed to be all for Lipkin.http://peoplewithme.com/Thread-Dont-worry-Ian-Lipkin-is-not-looking-for-XMRV?pid=2940#pid2940
This is pure speculation. Possible I suppose, but you have nothing to base the assumption on. Meanwhile we have actual reports from actual patients (not speculation) saying that the screening has involved detailed testing as per CCC.
Not to defend Fukuda, but this is not true. It is Oxford that only requires tiredness. Lipkin has said he is using CCC and Fukuda, as did Mikovits in Lombardi et al.
I have simply said that there is no actual source provided for this claim. Without a source, the assertion must be regarded with skepticism. I don't think I said anything about an attack? In general, I sincerely hope that this study makes full use of the skills and knowledge of Mikovits and Ruscetti. If they say different sample times is essential I will believe them.
As already stated, if you would only read, I "object as much as Gerwyn does to the stubborn insistence on using vp62 and defining XMRV according to it" (now why did I have to repeat that?). We do not, however, have any solid information to confirm what they are doing for this study.
What I think is irrelevant until a source is provided to back up the claim that this is what is being done. I will not attach a lengthy flame war on the use of contact controls to a discussion of the Lipkin study if this in fact has nothing to do with what is being planned. That would be highly misleading. Provide a source to back up the claim.
Awol,I hope that you will please reconsider your use of the words "Weeselian tactic" in your critique of Gerwyn's comments on Lipkin.Comparing a patient who is explaining his concerns about an important upcoming research project in that way isn't fair and it detracts from your own arguments.
ok, where? Can you post a link?Better idea - how about you actually do this yourself - or Gerwyn, and anyone else who wants to make this claim? Why the constant insistence that others do the work to support/deny your claims for you?
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iOS App of the Week: DeskConnect
updated 02:30 pm EDT, Fri August 30, 2013
DeskConnect content syncing
Earlier this week, DeskConnect -- a new tool for sharing content between Mac-based computers and iOS devices -- made its way into the App Store. Dubbed as the "missing link between all of your devices," DeskConnect includes support for transferring an array of content such as text, videos, documents, and even driving directions.
Setup couldn't get much easier. After downloading the Mac and iOS apps, users are prompted to either create a new account or log in with an existing one. Once an account is registered on multiple devices, everything is ready to go and content can be shared with only a few taps. The one exception to the ease of the sharing setup is website sharing; that requires users to setup a bookmarklet for every device.
For a first release, DeskConnect works surprisingly well. After the initial setup, we were able to quickly move a group of photos, some text, and web links between a MacBook, iPhone, and iPad. DeskConnect is even smart enough to open the Maps app when recieving a Google Maps link. Furthermore, within the preferences users can choose if they want to default to Apple's Maps app or the Google Maps iOS app. Most impressive is DeskConnect's price tag: the service is totally free, has no usage limits, and doesn't require a direct Bluetooth or Wi-Fi connection to work. Each device can be on its own network and content can be transferred just as seamlessly.
Our only real gripe with the software is where received files are stored on a Mac. The files are buried in an Application Support folder that isn't easily accessible, unless you know exactly where to look. Searching for the files in Spotlight also won't help, as the Library's contents are not displayed in Spotlight searches. The iOS app also currently lacks an iPad-optimized interface, but we have a feeling that an update in the near future will resolve these relatively small issues.


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I grew up in upstate New York where I was inspired by the vast beauty of the area. I remember walking for hours in the woods just to absorb the smell of the leaves, the sound of the creek and the trust of the animals surrounding me. I try to reflect that sense of peace in my paintings.
I learned to draw at a very young age, and am primarily a self taught artist and photographer. I practiced drawing portraits of my brothers and landscapes of the hills surrounding my home. I now work in both oil and acrylic.
I moved to Florida at 18 where I lived for several years, and then moved to Arizona where I've lived and worked for the past 32 years. I'm constantly inspired by the versatility of this state and am drawn once again to the deep woods of Northern Arizona and the Red Rocks of Sedona.
I've done many commissioned portraits and landscapes over the years and am looking forward to retiring and painting full time in the near future.
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Valve's Steam Machine torn down, reveals expensive, well designed, easily upgradable gaming PC
- By Sebastian Anthony on December 19, 2013 at 1:15 pm
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Those dastardly devils at iFixit have managed to get their mitts on one of Valve's 300 Steam Machine prototypes and, of course, torn it down. Inside is a quad-core Haswell Core i5-4570, a Zotac GTX 780 graphics card, 16GB of Crucial Ballistix Sport (PC3 12800) RAM, and a 1TB 5400 RPM Seagate hard drive. If you wanted to build your own SteamOS-powered doppelganger, it would set you back around $1300 to match Valve's Steam Machine part-for-part.
First and foremost, it's good news if you want to repair or upgrade the Steam Machine: The entire thing opens up with the removal of a single Philips screw. Once the upper case is removed, it's trivial to replace the hard drive. Remove a custom piece of plastic cowling and you then have access to the GTX 780 graphics card.
Getting at the motherboard and RAM is a little more tricky, however, as it requires the removal of a custom, tightly-fitted plastic cowl. The motherboard is a an ASRock Mini-ITX number (the Z87E), and the Core i5-4570 is cooled by the rather lovely Zalman CNPS 2X cooler. The motherboard, RAM, CPU, and cooler are all completely standard parts — you can replace or upgrade them as you see fit.
Beyond that, there isn't much else in Valve's Steam Machine. There's a 450W 80 Plus Gold PSU, and there's a fancy custom logic board harboring 12 LEDs behind The Big Button, and that's about it. iFixit also tore into the Steam Controller, with its two touchpads for thumbsticks, but there isn't a whole lot going on inside. Overall, iFixit gives Valve's Steam Machine a nine out of 10 for repairability, losing a point for the difficult-to-remove cowling and precise cable routing that makes it somewhat difficult to put the box back together again.
Finally, we should also take this chance to point out the machined holes on top of the Steam Machine. You may have noticed that one of the holes is shiny. In actual fact, there are 320 holes grille holes, and each of the 320 Steam Machine prototypes is uniquely marked by a different shiny hole. According to Valve, 300 Steam Machines were sent out to hardware beta testers, leaving 20 machines to hand out at Valve's discretion. Surprisingly, none of the big tech sites seem to have received one, but we're hearing that some developers have received them, along with some prominent PC gaming YouTube channels. I find it hard to believe that Valve would give iFixit a Steam Machine purely for tear-down purposes, but who knows. Considering how easy it was to put the Steam Machine back together, it's possible that iFixit simply borrowed someone's box for a few hours and then gave it back.
[Image credit: All images by iFixit]
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Basil Nolan
At least until some accessible pricing is revealed, it is more convenient to build your own gaming rig to your heart's content [or your pockets' depth], install SteamOS and you're ready to go.
Turo Orvel
I want that case and the controller.
agreed ^^ though i will never buy one (untill i have unlimited cash flow of course ) i am glad that pc are going living room ^^
Hell by the looks of it, the case looks perfect for a HTPC. Might as well install windows, then add the regular steam and get the best of both worlds, instead of getting an OS that just plays games.
Stacey Bright
You probably meant instead of getting an OS that just plays a fraction of the games that are available on windows. SteamOS should theoretically be able to run as a fully functional Linux machine though, so there would be more options to it than games. As far a gaming goes I don't expect much more than what already exists in Linux and Valve's first party source engine games. Maybe other developers will hop on board eventually, but that's what I'd expect initially.
i would like it if they jumped to linux but than i hope that linux will get a standard install folder like "program files" folder in linux. because if you want to tweak / mod the game then you have to find the program files which is harder to do in linux.
/home/.local/share/steam/ (steamapps/common/)
or you could go /home/.steam/ and there is a shortcut to /home/.local/share/steam/ in that folder. ctrl+h makes hidden folders (with a . in front of the name) visible.
/home/ is comparable to program files. most installed programs gets a hidden folder in there.
not just a fraction, but what else does it do? It seems that its trying to compete with consoles, but with no exclusive titles as Valve has stated that they are not interested in exclusive titles so what kind of appeal will it have then? I guess just to Linux users who want an alternative play other than windows.
Scott Jackson
You're missing one of the main selling points of it, which is that it can stream Windows games. The main idea is to be able to bring PC gaming to your living room to play on you big HDTV instead of moving your current PC or running long wires. You can play any Windows Steam game on your Steambox, however if you are just planning to stream games from a powerful PC to your Steambox then you don't need the beefy specs of this setup because it would just serve as a receiver to your streaming data with your Windows PC doing the heavy lifting.
So the selling point is just to stream?? That will be terrible and expensive. Might as well plug my pc to my tv and save bandwidth and money.
Scott Jackson
One of the selling points, along with the dedicated gaming SteamOS and Steam controller, and also the hardware could be cheaper than building it yourself. Yes you could just plug your PC into your TV and save the money, which is why the Steambox has had its fair share of critics, but not everyone wants to move their PC.
Stacey Bright
How is that a selling point? If it is still costly solution using 2 full computers to do the job of 1 computer. Between still paying for what a entry level gaming computer costs, and the cost in electricity running them both. If running wires is a problem for someone, we then have to assume this streaming is going to be done over wireless which I see potentially inducing latency. This might not be a problem depending on the type of game to be played, but if that's good enough then there are wireless display and input options that would prove cheaper still and more energy efficient. I'm seeing less and less value here.
Scott Jackson
Yes those are valid points. If the streaming capability is going to work at all minimal latency is a must. Also, having two gaming PCs yes would be both costly and impractical. It is kind of puzzling to me that they are making this high-end Steam machines that can run any game by themselves but also trying to sell the whole streaming capability. Do you want it to be a gaming PC or basically like a roku or chromecast but for gaming? Seems like they are trying to have their cake and eat it too. I don't think people are gonna buy these expensive Steam machines and then be willing to have another windows gaming PC to stream they games the Steam machine can't run natively. And I am not advocating that the Steam machine is necessarily a good idea, just pointing out its supposed "selling points".
I totally agree, I see less and less value in the so call steam machine. I'm not sure who are they aiming their products at, if you already have pc capable of playing games.
Stacey Bright
Well if its basically an X86 debian linux box, then it could potentially access a repository of endless open source alternatives to windows applications. So basically roughly as functional as a windows computer in everything but gaming ironically. That really relies on the end-user being comfortable with both linux, its 'alternative' applications, and not having or desiring a PC already running windows or linux. That other potential capability means you'll be hooking up a keyboard and mouse anyway. It can't properly compete against consoles or other PCs. So its only real option it just to try and exist, perhaps in its own little bubble, like Apple.
Scott Jackson
I think its main purpose is supposed to be for gaming and to be keyboard and mouse free. Yes it is ironic that the one area, gaming, that it is meant for would probably be its weak point compared to a Windows PC. That's where the streaming comes in…
Maybe they have a lot of secret developer deals going on behind the scenes and plan to have a couple dozen AAA games on Linux when the SteamBox officially goes retail.
Also, if they are planning on a year from now, maybe they think they can cut the price in half by then.
How does it not compete with consoles? The price is around that of consoles. It can run windows instead if you wish. Its upgradeable. Games are cheaper. No subs. Much much better graphics, resolution, fps, the list goes on and on. There is literally nothing the consoles have better than this machine at all.
Stacey Bright
I'll start off by clarifying that I'm definitely a PC gamer all the way, though I own a PS3. However for the target market of console gamers, the things that make PC gaming superior are of no consequence. You may also be misinterpreting the context by which I use compete. Mostly as in it doesn't compete with consoles (for business), because its clearly not meant to. You're still looking at $300-400 more than a console. Games are not cheaper, not the AAA titles at launch anyway. The subs you speak of aren't exactly mandatory and you're only hampered by not having one on the XBOX platform.
Then there are the exclusives, or temporary exclusive deals that keep a game from coming to PC for 6+ months after the console release. Oh and the ever so wonderful porting process we've all come to love so much in the past. The only thing I honestly appreciate about this gen of consoles is the X86-64 architecture, and its potential benefits to PC ports. The steam box however only has any benefit to those generally opposed to consoles (PC gamers), but doesn't already have a PC. Which in and of itself is quite contradictory.
At best Valve could use the Steam Box as a means of becoming a PC OEM, providing affordable gaming machines. Every other gaming PC vendor explicitly targets the high-end enthusiast market. This actually creates the concept among your typical console gamer that in order to switch to PC gaming they need an Alienware. I see the existence of the Steam Box potentially fixing that misconception. For everyone else 'in the know' we are already building our own machines.
Bad Conduct
Disagree about game prices. PC games are significantly cheaper, usually $10 cheaper at launch, and heavily discounted online. You rarely see COD for Xbox on sale.
Stacey Bright
Funny you mention COD specifically, seeing as at launch its $60 across all platforms. Yeah there are sales on PC titles, eventually, but all games get cheaper eventually. Many of 'Top tier' publishers have been releasing games at console prices on PC for a while now. Starcraft 2 (PC exclusive) remained at $60 what seemed like forever. BF4 PC is $60 on amazon right now. My statement was about asking price at launch, particularly involving AAA titles. Not even steam discounts a very recently released game during their sale periods. There was a time when you could expect the PC version of a multi-platform game to be $10 cheaper, but long gone are those days.
Bad Conduct
BF4 was already at 29.99 during black friday on Origin. Blizzard never discounts their games, but that's a stupid comparison considering it's PC only at this time. There any many console exclusives in the same price range.
It's the fact that, on Steam at least, downloadable PC titles often get heavy discounts. Console games on the shelves do not.
Stacey Bright
Yeah I missed that BF4 thing since I'm not fully onboard with Origin. I'm skipping it just like I did with BF3 anyway. Actually I'm pretty sure it supports my point with Blizzard with all the BS behind why console games are $60, for what reason should a PC only title be that price as well. I'm Activision in general lead the charge with upping PC prices anyway. I never said steam doesn't discount at all. I've repeatedly mentioned that I'm arguing original asking prices at launch. So if a game came out yesterday on PC with an original price of $60 in the middle of a steam sale, that game is still going to $60 probably at least until the next sale. That game would probably be in the COD series.
Then there is the fact that not everyone is comfortable with or even capable of relying on digital distribution. Those same PC games on shelves don't see those discounts either. There are still people that prefer physical copies, or just don't want to wait either for a download or an undetermined sale period of a specific title. The $60 price tag on console realistically works so well due to crowd mentality. Everyone wants to play it as soon as its out, because they know everyone will be playing it as soon as its out.
The publishers try as much as they can to pull the same thing on PC versions but the install base really isn't as high as console. Otherwise they just pull a Rockstar and just delay the PC release long enough that most have settled on the console version. Actually you do have the option of cheaper console games on shelves, its called USED. The same crowd that doesn't buy PC games at launch to wait on a sale are of the same type that specifically wait for the used console titles. The same companies that would try to kill the used game market would just as soon want PC gaming dead.
Bad Conduct
What do you mean, "pull the same thing?"
These games have million dollar development budgets. If they are not profitable, they won't get investments and they won't create sequels or even risk developing a new title.
And you are right, PC games on the shelves don't get discounted, nor can they be traded in or loaned.
I'm just saying, it will go on sale on Steam within 6 months, even for only 10% off, long before the console version takes a price drop. PC gaming is cheaper, because it's digitally distributed. Being ignorant of where to find the best price does not mean it's equally priced. It just means you're either not looking for deals, or want the game on release date.
Bad Conduct
What do you mean, "pull the same thing?"
These games have million dollar development budgets. If they are not profitable, they won't get investments and they won't create sequels or even risk developing a new title.
And you are right, PC games on the shelves don't get discounted, nor can they be traded in or loaned.
I'm just saying, it will go on sale on Steam within 6 months, even for only 10% off, long before the console version takes a price drop. PC gaming is cheaper, because it's digitally distributed. Being ignorant of where to find the best price does not mean it's equally priced. It just means you're either not looking for deals, or want the game on release date.
Stacey Bright
At some point it was decided to in the industry to raise the base price of games by $10 because the market would bear it. Its not like the $50 cost wasn't profitable, its about getting even more profit where they can.Gaming in general should theoretically be cheaper with digital distribution. Are referring to it being cheaper to manufacture, or cheaper for the consumer, because the two end up being mutually exclusive. Console titles also have the option of digital distribution. My argument still stands as "on sale within 6 months" has no bearing on the fact that the original MSRP of $60 exists on all platforms regardless of distribution method.
Bad Conduct
So, with many exceptions where "Ultimate edition" or "game of the year edition" is released on PC 6 months after for the same price as the original release on console with all the DLC. Or when PC games are released for 10$ less on Steam, or have a pre-release 10% off, or go on sale in less than 6 months (which often happens), THAN PC games are the same price. Which is not very often.
Console gaming is by far cheaper, most gaming PCs are above $1000. The argument that you could build a better gaming PC than a console for about the same price is pointless, because no one does that. People spend upwards of a grand on the graphics cards alone, and you wanna say PC gaming is cheaper? PC games can be cheaper then console games, but they usually don't sell as well as their console versions. Console gamers spend more money on games wheras PC gamers spend more money on equipment. Even then, with console gamers spending more money on games than PC gamers it's still cheaper to game on a console.
This is hard to believe but I'm up voting this comment Phobos.
I'm shocked as much as you are.
Exactly how upgradable are these things? Would it mean that I only need to buy this thing once and then continually upgrade as needed years later? Or will there be a time when I will have to (like consoles) purchase a new one?
Im debating whether to save money for this or build my own PC (which im leaning towards because i can use it for things other than gaming)
i think you can put all graphics cards in it as you like but it cant be larger than the GTX780, the motherboard looks like a ITX or mini ATX so you could just upgrade it al long as you stay within power budget and find a round cooler for the cpu.
Turo Orvel
There is a lot of room under the gpu so it probably fits one that have a bigger custom cooler.
It would depend on your preference. If you go with your own build you can get a case that is a bit larger that way you can keep adding more hard drives, use crossfire/sli, more ports, blah blah blah. With this you wouldn't have room for xfire/sli and it doesn't seem to have room for extra hard drives. This wouldnt be as open as your own build and would cost you more money down the road.
Think of it this way would you rather spend $100 and grab a 3tb HDD to replace the drive you have when its full? Or would you rather just slide in another to use together?
Would you rather sell your old GPU and buy a new one or save a bit of cash and buy an identical card to the one you have and expand its life that way?
But don't get me wrong some would rather have the small console sized form than the easier upgrading.
I would say steam machines should appeal more to people who want a set it and forget it small sized machine that games in great quality compared to consoles without all the locked up shit the consoles provide.
I love where steam is going with this and I understand what there intention is. They want to allow people an easy transition from something inferior to something with true power. They had to make it look similar and be super easy to just turn on grab controller and play. Then after the person making the transition sees what they were truelly missing out on they will notice the freedoms they have and will explore more and more into it turning them from peasant to master race.
I'd put a 256+ SSD and external HDD.
It looks like a nice piece of kit, lets hope the prices is acceptable. I'd like one for a living room PC.
Okay, so how much will this cost and what is the point? If it's highly subsidized and costs 800 dollars, it is still over double a PS4, albeit probably four times more powerful.
I think the point in the Valve-built steam machines isn't as a competitive console, and more as a proof of concept. I mean, seriously; 16 gigs of ram? What sane console maker would put 16 gigs of ram in a console?
It's gonna be much more interesting to me to watch the battle play out at the low end where the consoles lie. Give it a year of progression, and PC parts will be cheaper and faster that what is in the PS4 and XBO. At that point, it'll be a race to the bottom between the consoles and SteamMachine.
Kevin Moore
I don't think they are trying to compete with consoles for right now. I think they are trying to offer an alternative to the group of PC gamers who would rather buy a console than fiddle with trying to hook up their PC to the living room. They are also presenting technology that if it takes off will give them a huge lead and could potentially skyrocket them into the "console" market. That being streaming windows games and easily swappable/upgradeable hardware that can still be optimized for by developers.
Maybe after a few high end games are developed that maximize it's ability, they plan to release a second mid-range console with the performance matched to the PS4 and Xbox One, then say, hey look at how under powered the competition is. Now go buy a top tier SteamBox and do some cutting edge gaming.
Source engine 2 is coming soon. Titanfall uses source engine 1 and that engine was created by valve in 1997. At least valve knows that next gen games won't be built on engines from 16 years ago for hardware from 5 years ago. Valve said they don't believe in the exclusives crap the console manufacturers try to play as a good thing. They will be bringing there games to most platforms, the problem will lie with the consoles though. Expect for real next gen games to have major issues playing on inferior hardware.
Brian Thorp
Did they put enough paste on, dang!
Throws W7 on it and walks away
Heath Parsons
16 gigabytes of RAM in a console…Because soopa fast.
That's right super duper fast actually. 2-4gb for OS and other background apps you want running. Another 4-6gb for games. The rest can be used as ramdisk to load games instantly and never ever see a loading screen. So yes super fast!
"a Zotac GTX 780 graphics card, 16GB"
Sorry ps4, so sorry. this is THE next gen console
http://www.everythingillegal.com.au/ Damien O'Brien
This is steams reply to "This is how you make a NExt Gen" You Jerks!
Choking Kojak
I hate to say it but I'm impressed with this Steam Machine. I don't need one, though — I put together a desktop a few years back, now fitted with newer cards that keep it in shape for any PC game on the market right now
Here's the problem, though — Like I said, I am impressed with the Steam Machine.
I like it… Unfortunately, though, when I like something, it means that nobody or few others are going to like it.
As such, the Steam Machines is probably going to be a total sales disaster for Steam.
If I hated it, though, it'd be a monster success for Steam. I'm sorry Steam.
Valve is the company, Steam is the software. While you're right that this may not be very profitable for Valve, it will definitely be good for Steam. Each one sold is potentially a new Steam user, and therefore customer.
Choking Kojak
Yeah, but what? Maybe 100,000 buyers pick up a Steam Machine, then drop say $200-$300 on Steam games in a fiscal year?
So $20-$30 million in additional revenue thanks to the Steam Machine nudge? I guess that's something…
But frankly, like I said, I like the machine, I'd buy it myself if I wasn't already covered gaming-wise. And that likely means — in my humble decades of experience — that no seriously-sized chunk of the mass market is going to touch it.
It's really a damn shame.
Marble Shark
5400RPM HDD – LOL lame… it was all going so well. MASSIVE bottleneck, should have SSD as standard if you're already including expesive components like a GTX780.
Dave Harnett
The board has got mSATA and SRT support – an ssd cache could be a popular €50 upgrade. Spending hundreds on an ssd big enough to act as the primary drive would be overkill for all but the most spendy enthusiasts, particularly when the 16gb ram should allow for lots of pre-caching.
Winston Smith
Seems more and more like consoles are being supplanted by PCs that outwardly resemble consoles.
http://www.mygadgetsinfo.com/ Manender Bana
Dang. I thought i was going to buy a real steam machine, you know, as in one that runs on steam?
I don't know how they plan to releases this at a price comparable to the other consoles on the market, but the specs are fairly nice.
Funny thing is I and probably many of us reading this have been using the PC as a media center since 2006. Now we have Xbox one, and this bad boy working its way as an everything console. The way things are going it appears the new console will be a PC rather than the death of the PC.
This is doomed to fail. There is no way this is going to be sold as a loss. NVIDIA/AMD will lose a lot of money for it and well, other manufacturers will go broke too if they did. The ironic thing about this steam machine is it is targeted towards idiots/people with little knowledge of pc but it's attracting the PC enthusiast market. Why? Because it has Valve involved and there are a lot valve fanboys/sheep out there.
You sound like you'd be real fun at a party
I am actually a very nice guy in person(probably one of the nicest guys on this planet), but I won't tolerate bullcrap being thrown at my face. I am sure you don't either. While my comment may have been a tad bit hostile, but that is because many people on forums still can't give a clear answer as to how this machine is a game changer for the PC platform. The OS may offer some hope, but again, I want to see some REAL benchmarks first. I am not jumping on this bandwagon just because Valve has made it.
Sorry if I was negative, but I can't trust big corporates anymore.
Nicolas Edwards
Does not seem to be any diffrent than any other console or computer rig.
James Tolson
this is where in my opinion the steam box fails.. if the goal of valve is to create a "standard platform" that all games should run perfectly on then basing it on a standard PC hardware is never the way to go.. because next years games will struggle to run on it and the following years will not.. this then completely obsoletes the hardware.. what im dubious about is the business model? as anyone who ever reads my comments knows im ANTI drm/dlc microtransaction scams and landfill devise e waste scams the whole industry is now following since Apple led the way.. so this is the reason it will FAIL, People must surly by know see that getting roped into a product only to have Valve Steambox 2.0 dangled like a carrot 12 months later, then steambox 2s then 3 then 3s and so on and so on is borderline outrageous and hopefully the general consumer will bow out of their naivety like me and say "im out" before the first ever steambox goes on sale.. it makes much more sense to me just to build a general gaming pc and then install steam os on that.. but that in itself has its pitfalls.. no new game interests me anyway "except maybe Elite dangerous" and maybe "might magic 10″ but if i cannot run them on my current setup then im afraid i won't be playing them at all..
I would have loved to see a more special case, something STEAMpunk or if not then more futuristic or minimalistic elegant desing. Not a black box with many tiny holes :(. I hope is just a prototype. As for price, is obvious it will be in the range of latest gen consoles even if that means they will lose money at first, and untill will come out the price will drop at least 20% on each component, thats for sure.
Izzy Rallins
They put a 5400RPM hard drive in there? are they mad? That will slow down the whole system. Booting up, loading, texture swapping and the FAILURE RATES of 2.5″ hard drives! yuck!
Although, with the way nVidia is ripping people off for video cards ($240 for a card that is powerful enough to beat my old old GTX260 which was $180 4 yrs ago) it might be worth buying this just to get a GTX 780 and all those other components for cheap.
It's actually Seagate's SSHD (a hybrid SSD) if you take a look at the iFixit teardown. Most reviewers agree that SSHDs are the best price/performance trade off at the moment.
Izzy Rallins
They put a 5400RPM hard drive in there? are they mad? That will slow down the whole system. Booting up, loading, texture swapping and the FAILURE RATES of 2.5″ hard drives! yuck!
Although, with the way nVidia is ripping people off for video cards ($240 for a card that is powerful enough to beat my old old GTX260 which was $180 4 yrs ago) it might be worth buying this just to get a GTX 780 and all those other components for cheap.
Jeffery Neely
WOW! Looks nice… Better looking than Playstation! You can bet im GONNA GET ONE!!!!!
Mihai Cosmin Bianu
Can you install a micro atx motherboard on this steam machine case? Please somebody give me an answer?


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Scent of the Missing is a humorous, heartwarming and compelling tale that follows a golden retriever puppy and its owner through the grueling process of growing up, growing together and becoming a crack search-and-rescue team. It's part love story, part memoir and thoroughly engaging! Don't miss it!
By MPPL on November 8, 2010 Categories: Books, Nonfiction, Picks by Joyce, Staff Picks


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Undergraduate Academic Catalog 2012-2013
Home > Undergraduate Academic Catalog 2012-2013 > Degree Course Descriptions > Course Descriptions > English Courses > COMM 3150 Public Relations Practice
COMM 3150 Public Relations Practice
Prerequisites: ENGL 2030 or TCOM 2030
History theory, and practice of public relations, introducing students to the requirements of a public relations career. Students will apply fundamental principles of rhetoric and journalism to writing assignments such as news releases, backgrounders, feature stories, an editorials.
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"While shampoos and conditioners are clearly a must-have for groomers, they are also strong sellers in pet specialty retail. However, one way to be sure you are getting the most return on the shelf space devoted to these products is to make sure they are delivering what the customer wants.Surely, consumer demand will vary from store to store due to differences in demographics—bubbly paw baths and mud packs will probably not be big sellers in…"
"No matter whether you are grooming in a kennel, salon, mobile unit or a client's home, getting animals clean as thoroughly and efficiently as possible is vital to the end product. Dogs have to look great, smell wonderful and feel superb to the owner's touch. Dogs that require clipper and…"
" Contrary to common belief, while it is certainly true that some breeds shed more than others, there is no such thing as a dog with hair that doesn't shed. The difference lies in whether most of the shed hair easily slides out of the coat—as in the…"
" It's that time of year again—the time when no matter what pet owners do, their pets track mud, moisture and that doggy odor throughout the house. It is also the season when dry, static-driven tangles can appear overnight, and dogs and cats start itching and scratching due to dry…"
" While it is obvious to pet professionals that a pet's ears should be regularly cared for, it is not necessarily apparent to the pet owner. In fact, it doesn't occur to many dog or cat caretakers to look into their pets' ears until there is a…"


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NewsWatch: Energy
Blogging the business of energy with Tom Fowler and the Chronicle energy team
Monthly Archive for March, 2010
'Climategate' scientists didn't mislead, one investigation finds
A UK panel has decided that scientists involved in the "climategate" scandal did not misrepresent data or try to exaggerate the threat of global warming. The decision from the House of Commons' Science and Technology Committee is sure to be a relief to the scientists, who for several months have been lambasted by the media […] [Read More]
Shell's Perdido first to produce in deep water Gulf of Mexico
After more than 10 years in the making, the Royal Dutch Shell's $3 billion Perdido hub started producing today. In fact, the Perdido is first to produce oil and natural gas in that deep water region of the Gulf of Mexico, the Chronicle's Brett Clanton reported. The region where the massive Perdido is located is […] [Read More]
Iraq's plan to expand oil production too ambitious, CERA says
Yesterday, we wrote that $500 million in contracts were awarded to Weatherford, Schlumberger and Chinese firm Daqing to drill wells in Iraq's Rumaila field. The awards are part of BP's push to help expand Iraq's oil production. The country wants to boost production to 12 million barrels per day in the next six to seven […] [Read More]
Obama drilling plan gets modest industry praise, chilly reception from enviros. And you?
An Obama administration plan to open more U.S. waters to offshore drilling, including new areas of the Eastern Gulf of Mexico, offshore Virginia and Alaska, is getting a surprisingly positive reception from the oil and gas industry so far today. Steven Newman, head of Zug, Switzerland-based Transocean called the plan a positive. "From our perspective, […] [Read More]
Federal offshore drilling plan released
President Obama unveiled his new five-year plan for offshore oil and natural gas drilling this morning, but it's likely to be met with some opposition, the Chronicle's Jennifer Dlouhy reported. The President and Department of Interior's plan will open up new areas along the Atlantic coastline — some for the very first time — but […] [Read More]
Low natural gas prices send companies to the oil patch
We all know natural gas is a big deal these days. But natural gas prices are looking glum compared to crude prices and it may be driving some companies to look for profit in oil. Natural gas for May delivery on the New York Mercantile Exchange was at $3.97 per million British thermal unit, while […] [Read More]
Texas judges ping Corpus power plant
A massive pet coke-fired power plant project near Corpus Christi, Las Brisas, appears to have hit a snag (at least for now) in receiving a state air permit, according to the Corpus Christi Caller-Times: Las Brisas "has failed to meet its burden of proof on a number of required issues," the judges wrote. "Among other […] [Read More]
Chron Energy Newslinks | 03.31.10 | Perdido finds its way to production. 'Climategate' not a case of cooked books.
• Shell's deepwater Gulf platform Perdido starts up production, says source. • Federal offshore drilling plan expected today. • Gas prices are even pushing Chesapeake to look at oil. • Large BP investors say they support Canadian oil sands move. • Chevron wins $700 million arbitration claim against Ecuador. • Has the Alaskan gasline missed […] [Read More]
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The Pleasanton RAGE 04 White team finished off the spring season by taking 1st Place in the Silver East bracket. The team, coached by Luis Siu, has worked incredibly hard to achieve their early success. Way to go White 04!!!
The Pleasanton Rage Orange 03 team took 1st place the Spring Region 3/4 Premier bracket Sunday, by topping Livermore 4-2. The team known for their determined style of play includes
(front row, l-r) Natalie O'Sullivan, Kayli Shimanuki, Sophia Minnite, Maddie Benson, Leah Allari, (back row, l-r,) Coach- Tina Estrada, Ashley Belshe, Hayden Jolley, Caitlin Currie, Isabella Guerrero, Maggie Nostrand, Evette Allari and Ava Buckles. The team is moving onto ...
Pleasanton RAGE U11 White Team Wins NorCal League Championship
The RAGE U11 White team finishes league play with 10 wins 0 losses. They capped their championship run in the Region 3-4 Silver division with a decisive 3-0 victory this past Saturday against the Danville Mustang Stars. Rage White dominated their league with 6 shutout victories to carry a plus 16 goal differential, and a 4 game win advantage on the second place team.
Rage will play for the top State ...


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Welcome to the Wild Pacific Bed & Breakfast. We offer two beautiful rooms close to beaches and trails. Each room has a Private Entrance, Private Bath, Highspeed Internet Connections, Covered Cedar Deck All this beside the Wild Pacific trail !
Find a Pacific Rim Park, British Columbia bed and breakfast for your romantic weekend getaway. Intimate b & bs are cozy, romantic accommodations that are perfect for a mini-vacation, honeymoon, or wedding anniversary celebration. You will love the unique charm of our Pacific Rim Park, British Columbia inns. Many guesthouses include complimentary breakfasts and unbeatable hospitality. Browse our bed & breakfasts and plan your Pacific Rim Park, British Columbia romantic getaway today!


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Product 12/19
If you prefer the higher resolution and faster map access speeds of the latest RNS-E unit, it can be retrofitted with this straight-forward kit.
Package includes new RNS-E navigation system with gloss black surround and installation instructions.
Customers with RHD units will need to retain their existing bezel.
Pricing includes $600 core, which will be refunded when we get your old unit back.
- Installation available at our facility
This product was added to our catalog on Thursday 23 December, 2010.


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Police said a homeowner discovered a 17-year-old boy inside his residence carrying a shotgun during a burglary attempt Sunday.
Johnson City police responded to a residential burglary call at 2324 W. Brook Lane. The homeowner told police he had discovered a male burglar inside the residence and when confronted, the intruder ran from the residence. The homeowner told police the burglar was carrying a "long rifle" when he ran from the residence, according to a news release.
Police found a loaded shotgun near the reported victim's home. A search of the area was conducted and a 17-year-old boy was located in the area and identified as the alleged burglar.
The teen was charged with aggravated burglary, armed and dangerous felony and underage consumption. He was transported to the Regional Juvenile Detention Center, where he was awaiting a hearing.