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A process for the preparation of microcapsules containing biologically active material is disclosed. The process involves dissolving a polymer into a solvent into which the active material is also introduced; atomizing the resulting suspension or solution and collecting the droplets in a non-solvent for the polymeric droplets containing active material, resulting in coagulation. Subsequently, the coagulated droplets are hardened in a second non-solvent.
1. A process for the preparation of polymeric microcapsules comprising a biologically active agent, said process comprising mixing an active agent with a solvent to form a solution or suspension, dissolving a polymer in a solvent, which may be the same solvent used for dissolving or suspending the active agent, atomizing the formed solution or suspension, subsequently collecting the thus formed droplets in a non-solvent, and transferring the coagulated droplets into a second non-solvent.
2. The process according to claim 1, wherein the atomization process is ultrasonic atomization.
3. The process according to claim 1, wherein the polymer is biodegradable.
4. The process according to claim 1, wherein the polymer is a copolymer of lactic acid and glycolic acid.
5. The process according to any claim 1, wherein the second non-solvent is water.
6. The process according to claim 1, wherein the polymer is dissolved in acetone, the first non-solvent is ethanol or an ethanol-water mixture, and the second non-solvent is water.
7. The process according to claim 1, wherein the solution or suspension to be atomized comprises a non-solvent in an amount sufficiently small that it does not affect the solubility of the active agent.
The invention relates to a process for the preparation of biologically active agent containing polymeric microcapsules, which process involves dissolving a polymer into a solvent into which the active material is also introduced and forming droplets therefrom from which the solvent is subsequently removed.
A similar process is described in EP 301 969A1 (corresponding to U.S. Pat. No. 4,897,267) with the droplets being formed by emulsification of the active material containing polymer solution in a medium, usually mineral oil, which is not miscible with the solvent. The droplets are freed from the solvent by evaporation, after which a suspension of polymeric particles is obtained. Emulsification is also the principle of the process described in FR-A-2 491 351. In this process microcapsules are prepared by emulsifying active material and a polymer--both dissolved or dispersed in a solvent, for example dichloromethane--in an aqueous solution, after which the solvent is partly evaporated and further washed out through filtration, extraction and washing with water. Hardening occurs slowly during the process of evaporation and extraction. A disadvantage of this method is that it can only be applied batch-wise and that clotting of the filter can seriously hamper the process. A drawback to emulsification methods in general is the limited choice one has for the polymer solvent, a sufficiently soluble non-aqueous medium which must be volatile. Another drawback is that, upon emulsification of the polymer solution, the active material it contains may end up in the dispersion medium rather than in the polymer solution droplets. Further, such processes are not easily up-scaled.
Another process for making microspheres from Nukem GmbH of Alzenau, Germany is somewhat described in C.E. vol. 97 (November 1990). The spheres are produced by means of an injection moulding process from an initial liquid phase which is a fusion, suspension or solution. The liquid phase is passed through nozzles of a chosen diameter. The nozzle head is oscillated at intervals to interrupt the liquid phase flow resulting in homogeneously sized drops. The drops fall through a "reaction zone" where an undescribed coagulation process is initiated. Thereafter the microspheres are further shaped by an undescribed chemical reaction with a gas or liquid phase. The entire process is complicated and not very well described.
A different process for making microcapsules is atomizing a polymer solution into which solution the active material is also introduced, and subsequently removing the solvent from the droplets. Such a method is described in WO-A-9 013 780. In this method, the polymer/active agent mixture is atomized into a vessel containing a liquid non-solvent, alone or frozen and overlayered with a liquified gas, at a temperature below the freezing point of the polymer/active agent solution. The cold liquified gas or liquid immediately freezes the polymer droplets. As the droplets and the non-solvent for the polymer are warmed, the solvent in the droplets thaws and is extracted into the non-solvent, resulting in hardened microspheres. Drawbacks of this hardening method are the low temperature and long reaction time necessary for obtaining uniform spherical non-aggregated polymeric microsheres. Therefore, this method is unattractive for large scale production.
It would be an improvement in the art to have a relatively simple and straight-forward process for making microcapsules.
The invention provides a process for the preparation of polymeric microcapsules containing a biologically active agent which process is efficiently upscalable. The polymer solution droplets are formed by atomization in such a manner that the droplets contain the active material. These droplets are collected and coagulated in a non-solvent. The invention includes a process of the aforementioned type characterized in that the coagulated droplets are subsequently transferred into a second non-solvent.
FIG. 1 depicts the release of estradiol from microcapsule prepared according to the invention.
FIG. 2 depicts the release of the hexapeptide H-Gly-Gly-Phe-Met(O2)-D-Lys-Phe-OH (a β-endorphin 62-67 derivative) from microcapsule prepared according to the invention.
FIG. 3 depicts the release of the hexapeptide Org 2766 (H-Met(O)2 -Glu-His-Phe-D-Lys-Phe-OH) from microcapsules prepared according to the invention.
FIG. 4 depicts the release rate of bovine serum albumin from microcapsules prepared according to the invention.
Of course, the extent to which a liquid medium functions as a solvent or a non-solvent is dependent on the polymer type and biologically active material chosen. The artisan generally knows which solvent to use with which polymer and which non-solvent. Employing such knowledge, the process is essentially a fast and simple method for preparing polymeric microcapsules, especially microcapsules for in vivo use. The solvent and/or non-solvent may consist of a mixture of solvents and non-solvents.
Preferentially, both the polymer and the biologically active agent will be soluble in the chosen solvent at the temperature used during the atomization process. Also, preferentially, neither the polymer nor the biologically active material will be soluble in the selected non-solvent at the relevant process temperature. The solvent may also contain some non-solvent, so long as the concentration of such non-solvent is sufficiently low so as not to affect detrimentally the solubility of the biologically active agent or agents in the solvent.
Solubilities of various biologically active materials are given in, for example, Gennaro et al., Remington's Pharmaceutical Sciences, (Mack Publishing Co. 18th ed. 1990), and The Merck Index, (11th ed. 1989). Solubilities of various polymers are also available in various well-known texts.
Especially with regard to controlled release behaviour, parameters like particle size and particle size distribution are of importance. In preparing biologically active agent-containing microcapsules, the required values for these parameters, and therefore also the process conditions are determined by release-studies. A general rule, applicable to all polymers and all biologically active substances cannot be given.
In a previously described process (i.e. that disclosed in EP 301,969 and in FR-A-2 491 351) the parameters are determined by the emulsifying step, e.g. by the manner in which stirring is carried out. As is commonly known in the art, such a step should be adapted upon upscaling, of which the impact on surface and the impact on volume are different. In this respect, such a process is disadvantageous, since upscaling will lead to different results than those attained on a small scale, and new release studies will be needed.
In view of the above mentioned drawbacks, atomization methods are advantageous. After the process conditions have been determined, process upscaling can be effected simply by increasing the number of atomizing nozzles and by using a larger collecting capacity. In this way, the crucial step of forming the droplets in the atomization process is not affected by upscaling.
"Atomizing" may be accomplished by commercially available atomizers. Commercially available atomizers are also used to humidify air or goods, to inject gas into liquids, and to degas liquids. By using the term "atomizing", within the field of spraying liquids, it is clear that droplets are formed having a size of about 10-1000 μm, which size also indicates that the particles formed should be called "microcapsules". Of course, the droplet's size, which directly determines the particle size, can be tuned by adjusting the atomizer.
In this respect it is preferred to use an ultrasonic atomizer, which permits easy adjustment of particle size by varying the oscillation frequency. Ultrasonic atomizers are marketed, for example, by Lechler and are described in the technical information bulletin which accompanies the atomizer.
In the instant process, the droplets formed by ultrasonic atomization are first collected in a non-solvent. In this first step, the droplets remain intact, coagulate and some polymer solvent is extracted into the non-solvent. Subsequently, the first non-solvent is exchanged by a second non-solvent for hardening the microspheres.
The process according to the present invention may be applied to all polymers, provided that a suitable solvent and suitable non-solvent exist. A solvent can be regarded as suitable if the viscosity of the polymer solution can be kept low enough for the solution to be atomized. A non-solvent can be used in the collection step if the droplets remain intact, which means that polymeric films floating on the non-solvent are not formed and deformation or aggregation of the coagulated droplets is not observed. A non-solvent for the hardening step can be used if both the polymer solvent and the non-solvent of the collecting- and coagulating step are extracted by it and if the polymer hardens in this solvent. Conditions leading to favourable results should be determined per polymer type.
Polymers and co-polymers which are used as carrier medium for injectable controlled release dosage forms for therapeutics generally are biologically degradable. Preferably the polymer or co-polymer will contain bonds which can be hydrolysed to form non-toxic degradation products. Examples of such polymers include poly(glycolic acid), poly(lactic acid), copolymers of glycolic acid and L-lactic acid, gelatin, agar, starch, arabinogalactan, albumin, collagen, natural or synthetic materials or polymers, such as poly(ε-caprolactone), poly(ε-caprolactone-lactic acid ketone), poly(ε-caprolactone-glycolic acid ketone), poly(β-hydroxybutyric acid), polyethylene oxide, polyethylene, poly(alkyl-2-cyanoacrylate), hydrogels such as poly(hydroxyethyl methacrylate) or block copolyether-esters, polyamides, e.g., poly(acrylamides), poly(amino acids)(i.e. L-leucine, L-aspartic acid, β-methyl-L-aspartate, β-benzyl-L-aspartate, glutamic acid and the like), poly(2-hydroxy-ethyl-DL-aspartamide), poly(ester urea), poly(L-phenyl-alanine/ethyleneglycol/1,6-diisocyanato-hexane), poly(methylmethacrylate), poly-phosphazenes, polymers and copolymers of poly(hydroxybutyrate) and poly(hydroxyvalerate), poly(orthoesters), poly(orthocarbonates), poly(anhydrides), poly(alkyl-α-cyanoacrylates), poly(urethanes), poly(depsipeptides) and aliphatic polyesters.
Polymers of glycolic acid, lactic acid and copolymers of glycolic and lactic acid (PLAGA) are preferred. In the present field this preference is common, due to the good biocompatibility and release behaviour of these polymers. A further advantage to these polymers is their solubility in acetone, which to a certain extent is biocompatible. A preferred solvent for use with PLAGA is acetone, preferred first non-solvents for use with PLAGA are ethanol, water, and mixtures thereof. A preferred second non-solvent is water.
A further advantage of the invention is that it can be carried out at ambient temperature.
In the above-cited EP 0 301 969, the polylactide used is also dissolved in acetone, but due to the required evaporation of the solvent a heavier oil is needed to collect the polymer solution droplets, which eventually will lead to the polymeric microcapsules being contaminated. In using the commonly preferred polymers of lactic and glycolic acid a preferred embodiment of the process according to the invention has the further advantage that the polymeric microcapsules may be obtained in water, which is a strong non-solvent for those polymers and will not leave any contamination on the microcapsules. By virtue of the following general procedure, in fact all polymers for which water acts as a strong non-solvent can eventually be collected in water.
The general procedure according to the preferred embodiment of the present invention comprises using a medium which acts as a suitable non-solvent for the polymer to collect the atomized droplets and, after a residence time of several minutes to a few hours, transferring the particles to water. Directly collecting the atomized droplets of PLAGA in water generally will lead to a thin polymeric film on the water surface instead of microcapsules being formed. Specifically applied to the above preferred polymers, the atomized polymer solution droplets are first collected in ethanol. Hardening of the microcapsules in ethanol at ambient pressure and temperature is not possible; it inevitably leads to aggregation of the microparticles and/or gelation of PLAGA on the long term. Surface active agents may be added to the non-solvent during extraction of the (polymer) solvent to reduce the possibility of aggregation of the microcapsules.
In the presently most preferred embodiment, the microcapsules, as collected in the non-solvent, are vibrated loose by means of ultrasonic vibration.
As used herein, "a biologically active agent" is a substance having pharmacological or physiological effect. Microcapsules containing such substances in particular find use in the controlled release of drugs.
Preferred biologically active materials are medicinal compounds, especially those intended for chronic administration. Such medicinal compounds include peptides, such as LHRH antagonists; steroids; proteins, such as growth hormone or insulin; cytostatics, oligosaccharides and polysaccharides.
For veterinary medicine they can be used to deliver a very wide range of active ingredients e.g. glucocorticoids, gestagens, adrenergic agents, β-blockers, sedatives, and vaccines (adjuvants).
They may also be used to deliver insecticides, herbicides, pheromones and "repellants" to a local environment.
The invention is further explained by reference to the following EXAMPLES.
Procedure for manufacturing 10 g of estradiol loaded (5%) PLAGA microcapsules by the method according to the invention:
a. Dissolve 500 mg of estradiol in 10 g of acetone.
b. Dissolve 9.5 g of PLAGA in 30 ml of acetone.
c. Add the estradiol solution to the PLAGA solution and homogenize.
d. Atomize the estradiol/PLAGA solution with the Ultrasonic Atomizer US1 (Lechler).
e. Use 500 ml of ethanol as initial collection and coagulation medium.
f. Exchange after 1/2 hour the ethanol for the same volume of purified water.
g. Collect the hardened microcapsules after 1 hour by filtration.
h. Wash the microcapsules with purified water.
i. Dry the microcapsules at room temperature for 16 hours in vacuo.
j. Screen the microcapsule preparation through a 150 μm sieve.
Peptide and protein loaded PLAGA microcapsules are prepared in the same way, except for the fact that the active agents are not dissolved, but suspended in the PLAGA acetone solution.
Release studies on microcapsules made according to the invention were carried out on microcapsules containing a steroid (FIG. 1); different oligopeptides (FIGS. 2 and 3); and a protein (FIG. 4).
References herein to specific examples or embodiments should not be constructed as limitations to the scope of the invention which is defined by the appended claims.
Patent Citations
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This Code of Conduct (the 'Code') sets forth the standards of conduct which The Rank Group Plc ('Rank') requires of all its directors, officers and employees, including directors, officers and employees of all Rank's subsidiary companies. Any questions involving the application of the Code should be referred to Rank's Company Secretary (email firstname.lastname@example.com or telephone +44 (0) 1628 504250). Any allegation that any individual has contravened any of its provisions should be similarly referred.
Strict compliance with the Code is expected and any violation may result in disciplinary action.
Rank requires honest and ethical conduct, including the ethical handling of actual or apparent conflicts of interest between personal and professional relationships.
Rank promotes full, fair, accurate, timely and understandable disclosure in reports and documents, including financial statements, that Rank files with the Registrar of Companies and with the Securities and Exchange Commission, and in other public communications made by the Company.
Each individual shall, in so far as he/she is able to, seek to ensure that:
Each individual is required to support and promote Rank's long-standing commitment to operate in compliance with all applicable laws, rules and regulations in each jurisdiction in which it carries on business.
Any individual should promptly report any violations of this Code of which that individual becomes aware to Rank's Company Secretary.
Rank's Company Secretary is accountable for ensuring adherence to this Code (including ensuring prompt and consistent enforcement) and in this regard reports to Rank's Audit committee which is comprised solely of independent non-executive directors. A report will be given by the Company Secretary to the Audit committee concerning adherence to this Code at least annually.
Rank will make every effort to ensure protection for individuals who report questionable behaviour in light of this Code, in accordance with the Group's Whistleblowing Policy, a copy of which can be obtained from HR departments.
Any waivers to this Code for executive officers and directors may be made only by the board and must be promptly disclosed to shareholders, along with reasons for the waiver.

subset: commoncrawl


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Farmers' Almanac
Old Farmer's Almanac Predicts Colder Winter, Hotter Summer
The Old Farmer's Almanac, the familiar, 223-year-old chronicler of climate, folksy advice and fun facts, is predicting a colder winter and warmer summer for much of the nation.
Farmer's Almanac Predicted Thanksgiving Storm 2 Years Ago
The Farmer's Almanac predicted the Thanksgiving snow storm of 2013 a remarkable two years ago.
Farmers' Almanac Predicts Harsh Winter
KDKA AM's Larry Richert talks to the Farmers' Almanac Philom Pete Geiger about what is in store for this winter and next year's weather.
Farmers' Almanac: Wet Winter For Pittsburgh Area
Predicting winter weather is difficult no matter where you live, but the Farmers' Almanac has developed a reputation for being pretty reliable.


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Main Content
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There's no doubting your Pirates enthusiasm! Send out your cheers for Starling Marte as he takes to left field to make another exciting play for Pittsburgh in this replica Player Jersey from Majestic. It features a tackle twill team logo on the left chest, along with your favorite player's name and number on the back. Perfect for any fan who wants to be in the middle of all the Buccos action, this jersey provides the ultimate display of team pride for a die-hard MLB buff!
- 100% Polyester
- Drop tail
- Full button jersey
- Imported
- Jock tag
- Officially licensed MLB product
- Rounded hem
- Tackle twill graphics
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Comments about Starling Marte Pittsburgh Pirates #6 Majestic Replica Jersey - Black:
My son is quite a big boy so I was glad that this fit him perfectly not too tight had room to breathe
- Authentic Design
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Comments about Starling Marte Pittsburgh Pirates #6 Majestic Replica Jersey - Black:
This was the exact product I was looking for. Price was attractive. Delivery was prompt. Like it even better now that it is in my hands.
- Sizing:
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Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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Now Playing
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KRWG.ORG-The Region's Home Page
8:07 am
Wed January 23, 2013
NM Couple Arraigned In Child Pornography Case
A New Mexico youth football league president and his wife have had their initial court appearances after being accused of manufacturing and distributing child pornography.
The Bernalillo County Sheriff's Office announced the arrests last Friday of 42-year-old Fredrick Gonzales and 36-year-old Carey Gonzales after a four-month investigation.
The couple was in court Tuesday. They have their detention hearings scheduled for Wednesday afternoon.
Sheriff's officials say Fredrick Gonzales presides over the Young America Football League for the Albuquerque District.
They say Carey Gonzales works as a teacher's assistant at Montezuma Elementary School.
Authorities say a search of the couple's home produced several computers and digital media that contained child porn images.
They say the couple allegedly has admitted to viewing the images. The children in the images haven't been identified yet.
Copyright 2013 The Associated Press.


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South Africa won the second test against the British & Irish Lions to clinch a series win avenging the series defeat to the Lions in 1997 and inflicting a third series defeat in a row on the Lions.
The match ended in heart break for the Lions as full back Morne Steyn converted a long range penalty to steal the series in the last few seconds.
The Lions had dominated the match from the start until some untimely injuries saw key Lions limp from the field and reducing their effectiveness around the field.
Both props, Adam Jones and Gethin Jenkins were helped from the field as were the star centre pairing of Brian O'Driscoll and Jamie Roberts.
It is difficult to assess the extent of these injuries and any alleged intentions, but two Springbok players have been cited after the game, one of which led directly to Adam Jones leaving the field.
The Lions can hold their heads up high though in the knowledge that they dominated the game and it was only in periods of the second half that the Springboks played like the world champions they are.
Full back Rob Kearney opened the scoring with a well taken try in the corner and fly half Stephen Jones added a couple of penalties and a drop goal to give the Lions a 16-8 lead at half time.
Jones then kicked a further penalty to take the score out to 19-8 before the Bok's started their fight back with a try from Bryan Habana.
With four minutes of the match remaining Jaque Fourie touched down in the corner and following several minutes of deliberation from the television match official the try was awarded.
Morne Steyn converted to give the Boks a three point lead, but Stephen Jones kicked a penalty in the final minute to level the scores believing that the Lions had squared the match.
The game then took the final twist to stick the knife into the Lions when substitute Ronan O'Gara needlessly conceded the penalty in the dying seconds which Steyn kicked to seal the match and series.


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HIGH SCHOOL BASKETBALL: Capsules, 2/1
Lake View Girls at Plainview
What: District 4-4A basketball game
When: 6 p.m. today
Where: Plainview
Records: Lake View is 4-22 overall, 0-8 in district; Plainview is 23-8, 8-0
Of note: The Maidens will travel to first-place Plainview for their final road trip of the season. Lake View played a strong first half on the road against second-place Frenship on Tuesday before falling 48-29. The game was tied 9-9 after the first quarter and Lake View trailed 18-11 at the half. Katie Perez had nine points for Lake View and Darrian Velez added seven. The Maidens will wrap up the season at home against Lubbock High on Tuesday on Senior Night at Ben Norton Gym.
District 4-4A
All District
Plainview 23-8 8-0
Frenship 15-10 6-2
Monterey 15-13 5-3
Hereford 11-12 4-4
Lubbock High 11-16 1-7
Lake View 4-22 0-8
Tuesday's results: Frenship 48, Lake View 29; Plainview 69, Lubbock High 31; Lubbock Monterey 76, Hereford 54
Today's games: Lake View at Plainview, Lubbock Monterey at Frenship, Hereford at Lubbock High
Lake View Boys at Plainview
What: District 4-4A basketball game
When: 7:30 p.m. today
Where: Plainview
Records: Lake View is 8-16 overall, 2-4 in district; Plainview is 16-12, 5-1
Of note: The Chiefs are looking to bounce back from a 67-35 loss on the road against district leader Frenship on Tuesday. They trailed 41-22 at the half and scored just 13 points the rest of the way. Brandell Collins had a team-high nine points and Chris Ridgeway had eight in the loss. The Chiefs will play a pivotal game at home against Lubbock High on Tuesday in what could determine the fourth-place playoff spot.
District 4-4A
All District
Frenship 21-8 5-1
Plainview 16-12 5-1
Monterey 12-14 3-3
Lake View 8-16 2-4
Lubbock High 11-17 2-4
Hereford 9-15 1-5
Tuesday's results: Frenship 67, Lake View 35; Plainview 56, Lubbock High 54; Lubbock Monterey 72, Hereford 55
Today's games: Lake View at Plainview, Lubbock Monterey at Frenship, Hereford at Lubbock High
Central Boys vs. Coronado
What: District 2-5A basketball game
When: 7:30 p.m. today
Where: Babe Didrikson Gym
Records: Central is 17-10 overall, 8-5 in district; Coronado is 22-6, 10-2
Radio: 7:15 p.m. on 1260 AM KKSA
Of note: The Bobcats struggled Tuesday against first-place Permian, falling behind early and never seriously challenging the Panthers. KeVann Coney had 19 points in the loss for Central, which is holding on to a half-game lead over both Abilene High and Tascosa in third place. The teams met Jan. 2 in Lubbock with the Mustangs taking a 57-51 win to entrench themselves among the district favorites. Central takes Tuesday off before finishing with a pair of road games at Lee and Midland High.
District 2-5A
All District
Permian 20-6 11-1
Coronado 22-6 10-2
Central 17-10 8-5
Abilene High 17-8 7-5
Tascosa 15-11 7-5
Cooper 11-17 5-8
Odessa High 12-16 4-9
Lee 12-17 3-10
Midland High 6-24 1-11
Tuesday's results: Permian 87, Central 54; Tascosa 50, Odessa High 47; Abilene High 48, Lee 43; Cooper 59, Midland High 55
Today's games: Coronado at Central, Lee at Permian, Abilene High at Midland High, Cooper at Tascosa
Central Girls vs. No. 5 Coronado
What: District 2-5A basketball finale
When: 6 p.m. today
Where: Babe Didrikson Gym
Records: Central is 10-17 overall, 7-8 in district; Coronado is 31-1, 14-0
Of note: The Lady Cats picked up an impressive road win Tuesday, leading Permian throughout in a 14-point win over the Lady Panthers. Central got a big night from junior Brianna Torres, who scored 22 points for the Lady Cats in the contest. Emily Hurst added 15 and Amber Dubois had 10 for the Lady Cats who broke open a close game with a 18-point fourth quarter. Central wraps up its season with state-ranked Coronado, which hasn't lost a district game this season.
District 2-5A
All District
Coronado 31-1 14-0
Midland High 22-9 11-3
Abilene High 20-9 10-4
Lee 14-13 10-4
Central 10-17 7-8
Tascosa 10-19 6-8
Permian 14-15 5-9
Cooper 3-26 1-13
Odessa High 3-28 0-15
Tuesday's results: Central 62, Permian 48; Tascosa 37, Odessa High 33; Abilene High 53, Lee 52; Midland High 56, Cooper 29
Today's games: Coronado at Central, Lee at Permian, Abilene High at Midland High, Cooper at Tascosa
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Gear Review
Wicked Baselayer
Don't waste anymore money on synthetic baselayers. Merino wool is where its at. I had been wearing a UA coldgear mock shirt as a baselayer, it was heavy, always rode up and smelled like hell after a long hike. This stoic merino shirt is the bomb, its light, enough to keep you warm on cool days (~50F with wind today) but light enough to wear alone on warmer days to keep cool. layered under a windproof shell, it might be all you need. its lightweight and perfect for my kind of hiking and running. I'm 6'and 150lbs and the medium fits well.
Bottom line: toss your synthetics, pick up this merino, you wont regret it.
View More Details on Stoic Merino 200 Bliss Shirt - Long Sleeve - Men's


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Instamatic Presets
Instamatic Collection The Instamatic presets for Lightroom are presets that brings back the look, feel, unpredictable beauty, and fun of plastic toy cameras from the past. Every preset will change your lens, flash, or film. Each adds a unique touch to your photo, so mix and match to find your favorite preset from this collection of 18!
Instagram for Aperture
Instagram for Aperture From your iPhone app to Apple Aperture! Here are the most famous vintage Aperture presets on the net. If you are already familiar with the app, all you need to do is to apply any of the preset to your photo. You can also combine them by holding the command key while applying any additional presets to the same photo. Enjoy a blast from the past. Get the Instagram presets collection for Apple Aperture 3
Lightgram Presets
One-click Instagram. Ready-to-use one click Lightroom Adjustment Presets sharpen images, pump up vibrancy, perform quick exposure shifts, make easy white balance changes, and recover blown highlights. You can also experiment with a variety of effects, from sepia to cross process color shifts to black-and-white in different contrast grades. Apply any combination of adjustments with a single click. And because Lightroom Adjustments Presets are nondestructive in Lightroom 3, another click can remove effects and return your photo to its original state.
The Film Presets
This exclusive collection includes the Film Simulation 1 presets for Apple Aperture or Adobe Lightroom, a very useful Tool Box and a PhotoShop action to add film grain to your photos! Film Simulation 1 pack includes 30 unique Film Presets for Aperture or Lightroom: Kodachrome 10, Kodachrome 10 Expired, Kodachrome 10 Over, Kodachrome 25, Kodachrome 25 Expired, Kodachrome 25 Over, Kodachrome 64, Kodachrome 64 Expired, Kodachrome 64 Over, Kodachrome 200, Kodachrome 200 Expired, Kodachrome 200 Over, Kodachrome Memorial, Kodachrome Memorial Expired, Kodachrome Memorial Over, T-Max, T-Max Expired, T-Max Over, TRI-X 400 (Black and White), TRI-X 400 (Black and White) Expired, TRI-X 400 (Black and White) Over, Konica: Super XG 100, Super XG 100 Expired, Super XG 100 Over, Super XG 200, Super XG 200 Expired, Super XG 200 Over, Polaroid: XeL 600, XeL 600 Expired, XeL 600 Over.
Toy Camera Presets
Greetings! Your friendly staff at Toy Camera Presets is committed to provide you with the best quality retro and plastic camera presets on the net! In a moment in time where every cell phone owner went bananas with apps such as; Camera +, Hipstamatic and Instagram, a group of creative photography enthusiasts (the staff of Toy Camera Presets) decided to keep it real, after all we all know that your DSLRs are better camera than iPhones and Androids…That is probably why they are still called phones. In other words…we encourage you to bring your good digital cameras back on the road to capture some awesome images, process it with your favorite platform and play around with our gorgeous presets. We support both Apple Aperture and Adobe Lightroom so you don't have to switch back and forth. Feel free to browse our presets page to find your favorite collection! Show off your awesome results by joining our friendly "community" and publish your photo on our site.
Analog Camera Presets
Are you ready for the coolest analog look? Meet Sofia, the young lady with a red Vespa posing by the Spanish Steps in Roma. Her photo can use some analog vibes... Analog Camera Presets has just what it takes to boost-up tons of features within Sofia's picture. Look for yourself! This exclusive series is created with retro in mind. We took a gradual approach and each preset will get you closer to that special look that you love. After all, your pictures deserve more than plain presets. You're about to try something seriously cool.


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iming to provide more job opportunities for those with a criminal history, took effect in Indiana July 1.
House Enrolled Act 1482 was designed for individuals to have criminal convictions removed from their record. One hope accompanying the law was to increase potential employment for those with a criminal record.
However, according to Whitley County Superior Court Judge Doug Fahl, it is not the content of the law, but the implementation, that has been a problem during its first month on the books.
South Line Street has been closed for several projects this summer. Water main work is being done below the surface, and above ground work is being done on sidewalks, curbs and repaving the street. Columbia City Mayor Ryan Daniel said the street will be closed intermittently between now and the end of August. The mayor hoped the project would be finished before the end of the month, but some of the work is dependent on contractor schedules, so he was unsure of a finish date. "We know this can be frustrating for our residents," Daniel said.
Barbara J. Bloemker nee Denzel, 82, passed away Tuesday, July 30, 2013, at Parkview Regional Medical Center in Fort Wayne.
Born in Fort Wayne, Barbara served more than 30 years as a volunteer and past president of the Parkview White Cross Auxiliary,
She enjoyed crafts, making candy and baked goods to share with others.


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Give the gift of reading and ASL storytelling
Shared Reading Book Bags for the holidays, a great gift idea. Available in single-title book bags or sets of 10 different holiday titles.
The Clerc Center has a wide range of special holiday-themed collections for its Shared Reading Project (SRP) book bag series that would make a great gift for the holidays!
The SRP book bags are part of a research-based tutorial program designed to teach parents and caregivers how to read to their deaf and hard of hearing children using American Sign Language (ASL). Each book bag includes:
- Storybook
- DVD of the story signed in ASL
- Activity guide with ideas related to the story
- Bookmark: "Tips for Reading to Your Deaf Child"
The holiday book bags are available for purchase as individual titles or in sets of 10.
Individual holiday titles: (Individual book bags, $16.95 plus shipping and handling)
- At Christmas
- Clifford's Christmas
- Hooray! It's Passover!
- Hanukkah Lights, Hanukkah Nights
- My First Kwanza Book
- Seven Candles for Kwanzaa
- Passover
Group titles: (Set of 10 book bags-no substitutions, $150 plus shipping and handling)
Group F:
- Arthur's Thanksgiving
- At Christmas
- Celebrating Chinese New Year
- Celebrating Martin Luther King, Jr. Day
- Day of the Dead
- Easter Basket
- Five Little Pumpkins
- Hooray! It's Passover!
- The Birthday Cake
- Valentine's Day
Group H:
- Celebrating Cinco de Mayo
- Celebrating Presidents' Day: What is a President?
- Earth Day
- Easter Egg Hunt
- Gracias, the Thanksgiving Turkey
- Hanukkah Lights, Hanukkah Nights
- Made's Birthday
- Passover
- Seven Candles for Kwanzaa
- The Story of America's Birthday
Group I:
- Clifford at the Circus
- Clifford Makes a Friend
- Clifford the Big Red Dog
- Clifford to the Rescue
- Clifford Visits the Hospital
- Clifford's Christmas
- Clifford's First Valentine's Day
- Clifford's Halloween
- Clifford's Manners


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Find the best Indian Restaurants in Cannock as recommended by local Cannock people in thebestof Cannock's Indian Restaurants directory.
India Red is an established Indian Restaurant based in Hednesford with loyal customers throughout Cannock Chase. The restaurant has recently been fully refurbished to create a relaxing and welcoming modern atmosphere in which to enjoy the authentic home-cooked asian cuisine. Enjoy high quality food created by the talented chefs with friendly service in a relaxing atmosphere.
Danielle J said
family come here every friday if not saturday too, staff remember every ones faces and are friendly and comforting. food is brilliant, cant beat the tikka masala from here!! try it out
The Sanam Balti House Indian Restaurant has been established in Cannock since 1992 providing unique Eastern balti cuisine to an ever expanding loyal base of customers from Cannock and beyond. Enjoy quality food with authentic flavours from around the world whilst relaxing in the popular restaurant. 2012 - 20th Anniversary year!
John B said
The Sanam provides everything for a wonderful evening.
Eastern Memories provide the finest quality indian cuisine specialising in making indian cuisine with the minimal amount of cholesterol and fat but with maximum taste.
Diane B said
Al and his staff are fabulous!! the food and service is excellent!! If it's not on the menu just ask and they will cook it for you. Everything is cooked fresh to order.It is also low in fat and cholestrol. I eat there at least once a week and more if i could. Al takes time to speak with everyone of his customers old and new.
Spice Bazaar is an Indian Restaurant proudly serving traditional and contemporary Indian Cuisine to customers throughout the Cannock area. The recently refurbished restaurant provides a unique atmosphere thanks to the intimate room settings. The service provided is friendly and professional with every customer given a warm welcome. The restaurant also boasts a fully stocked bar to complete the dining experience.
Jim H said
My wife and me have been to this restaurant many times and with the exceptional choice of menu have tried a new dish for us and received yet another mouth watering meal full of flavour and just the right amount of spice and chilli. We have been to many Indian restaurants in many towns across the UK over the years and this one is our favourite for quality dining. The staff are always so friendly and willing to make your evening special. I strongly recommend this restaurant, give it a try.
Padma Lounge Bar and Restaurant is an established Indian restaurant that has been providing fine indian cuisine for Cannock and the wider area since 1971. Visit the rich and warm restaurant for high quality Indian cuisine from this family run restaurant.
Adil T said
The Chicken Naga from The Padma Lounge may be the best Naga dish served in the UK. That good!


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Was the clutch problem truck related or poor driving skills and bad habits.
To me that is like saying the brakes always need changed after 15000 miles.
Those items depend on good driving techniques to last a long time.
Hard stop and go will ruin brakes and riding the clutch instead of good smooth shifting should not be held against the truck, model, or its maker.
I also just read the "Favorite Features"
listed as "Fun to Drive"
which makes me believe it is driving skill and practices that are going through clutches and not truck malfunction.
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Yesterday, as David Booth was surrounded by a massive horde of hockey writers cramming cameras and microphones into his face like grandmas with spoons full of pudding, Canucks' coach Alain Vigneault walked past and said with a chuckle, "Welcome to Vancouver."
Yes, things are a little different here. While I won't go as far as to say that no one cares about hockey in Florida — although, when an infomercial outrates your live game telecasts, um, the point sort of makes itself — it's safe to say that the editorial board of the Miami Herald isn't suggesting roster moves. No, that only happens here.
Pretty much everything David Booth does now is a story, and if there's a way to turn it into a controversy, you'd better believe somebody's on it. For instance, had Booth chosen to sit out Tuesday morning's optional game day skate on the morning of his debut — a reasonable option, since it was optional, and he's probably exhausted — it would have been a story.Continue Reading —›
The Canucks have scored eight goals over the past two games, meaning you have had eight chances to notice that the team has been rocking a brand-new goal song for the past week (and it would have been more if they hadn't been shut out by the Rangers — the song was supposed to debut last Tuesday).Continue Reading —›


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Earlier this year, we learned that Microsoft was working on a prototype operating system called Windows Cloud. This operating system has been rumored to require an internet connection for full functionality, acting as a basic operating system when in offline mode. Rumors indicated that Microsoft was allegedly referring to this operating system as Windows 365.
Now, we are seeing some new details emerge about Windows 365, courtesy of two LinkedIn profiles of two project managers. The project in question is Windows 365, and we now know it has something to do with being a customizable cloud based operating system that works on different devices.
"Presented at Microsoft HQ to Gonnie Been, the project combined Steve Ballmer's "One strategy, One Microsoft" approach with Satya Nadella's "Mobile first, cloud first world" direction. The project involved the new OS platform "Windows 365", which is cloud based and unites all smart devices," one LinkedIn profile states.
"Alignment the one strategy with "Mobile first, cloud first", we generated the "Windows 365" which is an OS platform in cloud enabling users to log into their own customized OS in different devices," another profile states.
These two project managers are not Microsoft employees (at least according to their profiles), but they seem to be involved in Microsoft's Windows 365 project.
This isn't the first time we've heard of Windows 365 and it seems like this wont be the last time we hear of it. What does Windows 365 have to do with Microsoft's Windows 9 operating system is still unclear, but one thing seems certain for now -- Microsoft seems to want to create a cloud-based operating system platform that is easy to customize and works on all types of form factors.
Now, could the term "Windows 365" simply refer to Microsoft's grand vision of having one operating system across all devices? That could be possible too. More on this as it develops.
Update: Now we are hearing that this could be an "MBA proposal" to Microsoft, rather than an actual Microsoft project. This is uncertain and unverified, but you can check out the slides here and decide for yourself.
Update 2: Looks like it is indeed a school project. Check out the blog post about it here. Even though Windows 365 was simply an idea for a school project, Microsoft is already definitely looking to head in the direction of having one operating system for any device. It will be curious to see what sort of plans Microsoft has for Windows after Windows 9 becomes available.


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Mr. Colin Owyang is Executive Vice President of Regulation and General Counsel of National Grid USA. Prior to joining National Grid, Mr. Owyang was an Assistant U.S. Attorney in Boston, a Special Assistant U.S. Attorney in Washington, D.C., a Trial Attorney in the Environmental Crimes Section of the U.S. Department of Justice, an associate at the law firm Foley Hoag in Boston, and a judicial clerk for three federal judges in Boston, MA and Detroit, MI.
Mr. Owyang serves on the Council of the Boston Bar Association and the Board of Directors of the Boston Lawyers' Group. He previously served on the Massachusetts Judicial Nominating Commission and on the U.S. Magistrate Judge Interviewing Committee. Mr. Owyang is also on the legal committees of the Edison Electric Institute and the American Gas Association. Mr. Owyang was appointed to the Framingham State Board of Trustees in 2014.
Mr. Owyang is a graduate of Yale College, Yale University and the University of Michigan Law School.


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— Cuba Gooding, Jr. as Rod Tidwell from Jerry Maguire, 1996
You are Here » News Chat » First CRAZY World War Z footage
November 6, 2012
First CRAZY World War Z footage
— Posted by The "Superior" Anthony
That didn't give me much in terms of plot, character, or much of anything but good lord those few snippets of chaos are downright exhilerating. The approach seems to be a strong contrast from what we've seen from zombie productions lady with a much faster pace than even the 28 days/weeks later films for the undead. Very curious, very exciting, and furthermore it washes away the apprehension I've had from this film in the past. Can't wait to see a proper trailer.
Via: Geek Tyrant
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No other party in Zimbabwe's history surely ever had the sheer audacity that ZANU PF displays in, on the one hand, carrying out the most dastardly acts, and on the other, dressing up those acts to look respectable. Time and again they claim the most noble motives to justify the most ignoble deeds. So in the year 2000, when the party's popularity was plunging and in order to divert attention from the chronic failures in governance that were then showing up in significant social and economic problems, they undertook a programme of violent and unlawful farm invasions. They called it the Third Chimurenga and used their state-controlled propaganda machine to portray the exercise as correcting long-standing grievances arising from historic inequalities in land holding. A mask of respectability to conceal an unpalatable truth.
So too in the last few weeks we have seen ZANU PF launch a massive blitzkrieg against urban dwellers whom they have conspicuously failed to persuade to vote for the party in the last three major elections. This is nothing other than political retribution, with no doubt a sub-plot of depopulating urban areas and forcing people back to their "rural homes" where ZANU PF thinks it can the more easily manipulate and control them. In other words social engineering by means of forced migration, and carried out with the kind of ruthless efficiency for which Hendrik Verwoerd and the founding fathers of South Africa's Apartheid were once noted. Still the spectacle of thousands of street vendors being brutally ejected from their homes and workplaces and hundreds of thousands of families rendered homeless and destitute, was never going to be a pretty sight, so ZANU PF did two things to minimize the public relations damage. First they reduced media coverage as far as possible, and second they did their best to portray the exercise as a necessary "clean-up", anti-crime operation. It was therefore given the code-name "Operation Murambatsvina" ("Operation Drive out Trash) - though this only begs the question, what in Mugabe's and ZANU PF's view is "the trash"? A working definition for them seems to be anyone foolish enough to resist ZANU PF tyranny.
One ZANU PF chef who has not been linked too closely with the "clean up" operation is the Governor of the Reserve Bank, Gideon Gono. For this gentleman is more image conscious than most in the party. He would like Zimbabweans, and the world, to think of him as a man with, as the Bible puts it "clean hands and a pure heart". Indeed Gono has gone to some pains to portray himself as very religious. He never speaks of his mission to save the economy (and Zimbabwe?) without a touch of evangelical zeal, and his speeches are littered with the most pious-sounding quotations from the Scriptures. To cite his recent Monetary Policy Framework as just one example, the writer noted no fewer than five Biblical allusions at one glance - including references to Sodom and Gomorrah and the unfortunate Lot's wife (who was turned into a pillar of salt), a rather free rendering of Jesus' experience in the Garden of Gethsemane where (according to the learned Dr Gono) God said "My Son, take it like a man …" (!) and a quotation which we have not been able to trace yet (but are sure we will be able to find eventually) to the effect that "God will help those who stand up to help themselves". Obviously Gono has a superior version of the Bible to any the writer has - perhaps "The Expanded Bible" - but the point is the man obviously takes the Christian faith with some seriousness. He ends his presentation "In the Lord's hands, I commit this Monetary Policy Framework for our economic turnaround." In a country noted for its religious observance, Gideon Gono comes across as a true believer. And such an image is certainly a political asset in Zimbabwe, as he well knows.
It is when one studies the text of Gono's recent speeches more closely that an interesting link emerges with Operation Murambatsvina. His "Post Election and Drought Mitigation Policy Framework" was delivered on May 19 and published in full in a special report carried by the state (ZANU PF) media the following day - in other words just a few days ahead of the commencement of the savage reprisals against the informal sector and poor urban classes, of which those outside the inner sanctum of ZANU PF policy-makers were then blissfully unaware. Here are a few excerpts from his speech (the italics are ours):
1.13 "Yesterday it was the financial sector in the forefront of illegalities. Today it is individuals ……….. who are in the forefront of parallel market dealings and other economic crimes."
1.14 "Today, it is the parastatals, it is the local authorities …. among others where the rot needs thorough cleansing along the same lines that we did with the financial sector. Let there be no outcry when the long arm of the law extends itself to these sectors, as indeed we believe, it will soon do."
31.1 "With the Parliamentary Elections now over, the marked peace and tranquillity prevailing in the economy forms a solid launch-pad to deepen our turnaround thrust."
The conclusion is inescapable - when formulating his Policy Framework speech the Governor of the Reserve Bank was fully appraised of the social and economic tsunami that ZANU PF was just about to unleash on the nation. Not only so, but he clearly approved the basic tenets of the policy, witness his remark: "the rot needs thorough cleansing". He knew that the blitzkrieg would cause massive upheaval and expected a strong voice of protest to be raised against it: "Let there be no outcry when the long arm of the law (sic!) extends itself to these sectors." He was also aware of the timing "…as indeed we believe it will soon do", which was no doubt deliberate; based on the ZANU PF's reading of the post-election climate "… the marked peace and tranquillity prevailing in the economy forms a solid launch-pad to deepen our turnaround thrust".
At the very least then Gideon Gono knew and thoroughly approved the massive assault on the civil liberties of the informal sector and the urban poor which was about be launched on the unsuspecting Zimbabwean public. Indeed, in terms of political philosophy and economic policy, Murambatsvina so closely fits the successive stages of the so-called anti-corruption drive of which Gono was the author that it is difficult to resist the conclusion that this too was his brain-child - perhaps the capstone of his intended reforms. So much for his professed strong Christian convictions - and the pious clichés that he trots out regularly to spruce up his personal image (as indeed do a number of other ZANU PF heavyweights who are equally guilty of the most heinous crimes against humanity). Evidently he, and they, are unaware of another strain of the Scriptures which pronounces the most severe judgment on those who oppress the poor, along the following lines:
"Woe to those who make unjust laws, and those who issue oppressive decrees, to deprive the poor of their rights and withhold justice from the oppressed of my people, making widows their prey and robbing the fatherless …" (Isaiah 10/1-2)
And while we are quoting the Scriptures another passage comes to mind as particularly apt:
"Woe to those who call evil good and good evil, who put darkness for light and light for darkness, who put bitter for sweet and sweet for bitter." (Isaiah 5/20)
A salutary warning surely for the ZANU PF spin-doctors, of whom Gideon Gono must be reckoned one of the foremost.
But the purpose of this article is not simply to expose Gideon Gono's appalling hypocrisy. It is to call into question the motives of all those who accommodate themselves so easily to his hypocrisy, and indeed assist him in the task of selling the most odious policies of a fascist state as nothing more than economic good sense. And here we have in mind the likes of Eric Bloch who sits on the Reserve Bank Advisory Board, and regularly sings the praises of Governor Gono. Eric Bloch well knows two things - first, that this ZANU PF administration is perpetrating unspeakable evils on the poorest and most vulnerable section of the population, and second, that his presence on the Advisory Board and his readiness to be an apologist for Gono's (and ZANU PF's) policies, tends to add some measure of respectability to the same.
We find this behaviour rather strange, particularly given Eric Bloch's own background, coming as he does from a religious minority (the Jews) who have suffered the most appalling persecution under fascist leaders like Adolf Hitler. Indeed we understand that Bloch's own parents were survivors of the Holocaust. Perhaps then he should refresh his memory on some of the atrocities committed by that other fascist dictator. As has been noted by many with an historical sense, the parallels between the Nazi dictator and our own are striking. In the context of Murambatsvina perhaps the closest historical parallel was Kristallnacht, the "Night of Broken Glass" (November 9, 1938) when Hitler's Storm Troopers went on a wild orgy of violence against Jewish persons and property, while the police were ordered not to interfere. The toll of that night's violence included 91 Jews killed, hundreds seriously injured and thousands more humiliated and terrorized. It is recorded that about 7,500 Jewish businesses were gutted while scores of synagogues were destroyed.
Let the Eric Blochs of this world know that they will be judged - indeed their fellow Zimbabweans already judge them most harshly - for their complicity in the ZANU PF persecution of the nation's poorest and most vulnerable. The same can surely be said of any who join, or remain on, the Gono gravy train. The fact is that we have long since passed the point at which giving moral, financial or any other kind of support or encouragement to this murderous regime must be considered a betrayal of the basic tenets of justice and mercy of the great Judaeo-Christian tradition.
And a final verse of Scripture for our Bible-bashing Governor of the Reserve Bank and those who do his bidding:
"(Jesus said) Watch out for false prophets. They come to you in sheep's clothing but inwardly they are ferocious wolves. By their fruit you will recognise them" (Matthew 7/15-16)


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Cooking and Baking
What to do with stale macaron shells?
I made macarons last week but unfortunately didn't have enough mouths to feed them to, and the unfilled extra shells have gotten hard and stale. Do y'all have any idea if I can do something with them? They're alright eaten plain - a different texture than I'd like but I wonder if I can transform them into something else. I was thinking maybe crushing them into a sweet topping for fruit? Any other ideas?
Talk is closed, but that doesn't mean the conversations have to stop!
Check out this post for a more thorough explanation, and jump onto our Facebook page or our Twitter feed to keep the conversations going!


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High School Football Preview: Santa Fe
Published August 15th, 2012
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Alachua- Santa Fe Raiders quarterback Swandrick Miller may have expressed the difference between losing seasons and winning seasons better than any sportswriter could try.
"When you're 1-9," says Miller, "at school you're trying to hide your head, run around corners. But when you're 8-3, you can walk with your head high and chest out."
The Raiders held their heads high with a playoff appearance in 2011, and even though there has been a coaching change-Bill Wiles replaces Tommy Keeler- there is still confidence from the team that another playoff run is in the making this year.
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- Game of the Week Preview: Buchholz vs. Columbia
- SEC Media Days Preview: 5 Questions We Want Answered


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|Days Inn McGaheysville hotels are listed below. Search for cheap and discount Days Inn hotel rooms in McGaheysville, VA for your business gathering or personal travels. We list the best Days Inn McGaheysville hotels + motels so you can review the McGaheysville Days Inn hotel list below to find the perfect place.
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Chesapeake, Coal Grove meet for Little Brown Jug
CHESAPEAKE, Ohio -- At the start of the season, Chesapeake High School football coach Andy Clark and Coal Grove coach Dave Lucas had winning the Ohio Valley Conference football title as one of their objectives.
One team will take a big step toward achieving that goal Friday when Chesapeake (4-4) and Coal Grove (4-3) meet in a 7:30 p.m. game at Coal Grove. Both teams are 3-0 in OVC play.
"We've put ourselves in position to have that shot," Clark said Monday.
The winner also gets possession of the Little Brown Jug traveling trophy. Since the Hornets are defending OVC champs, that trophy currently is theirs, too.
Coal Grove is the game site because Chesapeake's stadium is undergoing renovation. Bleachers and the press box are up on the home side and bleachers on the visitor's side are up as well. The new field turf has been installed, but not ready to be used. Since the work (a new track is included) wouldn't be completed before the 2012 season started, Chesapeake had to play all 10 games on the road this season.
The Panthers practice on their baseball field.
Clark said he had a meeting with his seniors prior to the start of the season. One of the topics was playing all road games.
"They had 10 minutes to complain. Going out the door I didn't hear anything," Clark said. "They've handled it as well as they could. The joke about it some. They want to play at home. It's short trips now. That (no home games) is not the issue."
Both schools played difficult non-league schedules. Coal Grove lost to Wheelersburg (7-1), Lucasvilley Valley (8-0) and Columbus Bishop Ready (7-1). Chesapeake lost to Oak Hill (7-1), Wayne (7-0), Lucasville Valley and Portsmouth West (3-5).
"Good competition gets you ready for the league," Clark said.
In the OVC, the Panthers have beaten River Valley, Fairland and South Point. The Hornets have wins over Rock Hill, River Valley and Fairland. Against Fairland, Chesapeake overcame a 19-7 deficit to win, 26-19. Meanwhile, Coal Grove led the Dragons, 16-8, at the half and pulled away the final two periods for a 28-8 win.
"We backed ourselves in a hole," Clark said of the Fairland game. "We started to execute the changes we made at halftime. It all revolved around defense. We picked things up."
Against Fairland, Jacob Collins carried seven times for 121 yards and three touchdowns. He followed up with 138 yards on 21 carries and three more TDs in last week's win at South Point.
Clark knows Coal Grove has many ways to attack his defense. It starts with quarterback Alex Bare and continues with running backs Isaiah Gunther, Kyle Estep, Brandon Hogsten and Tanner Murphy. End Sean Paulus can't be overlooked as the caught three passes, all leading to first downs, in the win over Fairland. Then there's the big guys up front.
"They give you a lot to account for," Clark said. "Bare's a good quarterback and the fastest we've seen. They stay fresh, the line is big and strong and they can throw."
Two years ago, Chesapeake beat the Hornets, 25-22, at home to complete a 5-0 OVC run after starting 0-5. Last year, Coal Grove prevailed, 20-15, on its home field.
"It comes down to execution, mistakes and who wants it more," Clark said. "Our goal is to play well enough to give ourselves a chance to win at the end."


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The Audition:
Self-Titled Album CD
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With their third release, The AUDITION create yet another ambitious pop-rock record oozing with hooks that steps into the radio-friendly realm.
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Mark Dempsey: American government has the legal right to create literally unlimited dollars, so it can never be insolvent. It will run out of dollars when the Bureau of Weights and Measures runs out of inches.
The Jobs Crisis, the "Unemployable," and the Fiscal Cliff
Friday Feedback: LIBOR and Super PACs
Friday Feedback: True democracy – 'capitalist' or otherwise – doesn't need or use a special class of politicians, let alone politicians whose concentrated power makes them attractive and ready recipients of corruption.
We Twisted King's Dream, So We Live With His Nightmare
Palm Springs Weekend
Sharon Kyle: The billionaire Koch brothers, David and Charles, are hosting their bi-annual meeting of right-wing billionaires. Odds are you're probably not a right-wing billionaire and weren't invited to their event. But, no worries, a coalition of progressive organizations has planned an event just for you.
Color Blindness
Steve Hochstadt: Our nation also has far to go. Claiming that we are color blind, that whites no longer have privileges in America, that we need no longer worry about preventing discrimination is nonsense. One need only have observed the reception of our first black President to know how important skin color still is in America.
Reagan v. F.D.R.
Why A Civil Society Extends Unemployment Benefits
Robert Reich: A record number of Americans is unemployed for a record length of time. This is a national tragedy. It is to the nation's credit that many are receiving unemployment benefits. This is good not only for them and their families but also for the economy as a whole, because it allows them to spend and thereby keep others in jobs.
Full Disclosure of Congressional Stock Portfolios
The End of the Ownership Society?
In his second inaugural address, President George W. Bush offered a vision of an "ownership society" In America's ideal of freedom, citizens find the dignity and security of economic independence… To give every American a stake in the promise and future of our country, we will… build an ownership society. We will widen the ownership […]
If They're Too Big To Fail, They're Too Big Period
by Robert Reich — According to Treasury Secretary Hank Paulson, the biggest Wall Street banks now getting money from the government are just "too big to fail." Fed Chairman Ben Bernanke uses a different euphemism – he calls them "systemically critical." The point is that if any of them goes down, it could take the […]
Politics, Art, and California's Public Policy Failure
California is mired in a $16 billion dollar deficit, without the political will to overcome deliberately designed structural impediments to solving the problem. For most government and nonprofit organizations, mission determines function. The United States Constitution clearly lays out the 'mission' of the government in the Preamble: "to form a more perfect Union, establish Justice, […]


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Meat Hooked! with Director Suzanne Wasserman The Graduate Center
365 Fifth Avenue
Segal Theatre
Suzanne Wasserman, who heads the Gotham Center for NYC History, screens her latest documentary, about the city's butchering industry (Best Feature, NYC Food Film Festival). Wasserman's previous documentaries include Thunder in Guyana, Sweatshop Cinderella, and Brooklyn among the Ruins. She will be interviewed by acclaimed and bestselling author Julie Powell.
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It's just a bench press from the floor. We do it narrow gripped, with your elbows by your sides to mimic the pressing position of the push-up and ultimately the handstand push-up.
BDNF, Hippocampus. Are those in your vocabulary? Perhaps they should be. Brain Derived Neurotrophic Hormone supports the survival of existing and the formation of new neurons in the brain, especially the hippocampus. The hippocampus - the area of the brain where learning and memory take place. Makes sense that BDNF is good for learning and memory, so how do we get BDNF?
Surprise: exercise.
Think maybe that's important for us? How 'bout our kids and teens? You Betcha.
It has long been a cliché that muscle bulk doesn't equate to intelligence. In fact, most of the science to date about activity and brain health has focused on the role of endurance exercise in improving our brain functioning. Aerobic exercise causes a steep spike in blood movement to the brain, an action that some researchers have speculated might be necessary for the creation of new brain cells, or neurogenesis. Running and other forms of aerobic exercise have been shown, in mice and men, to lead to neurogenesis in those portions of the brain associated with memory and thinking, providing another compelling reason to get out at lunchtime and run.
Since weight training doesn't cause the same spike, few researchers have thought that it would have a similar effect. But recent studies intimate otherwise. Several studies involve animals. It's not easy, of course, to induce a mouse or a lab rat to lift weights, so the experimenters have to develop clever approximations of resistance training to see what impact adding muscle and strength has on an animal's brain. In a study presented at the annual meeting of the Society for Neuroscience in November, researchers from Brazilsecured weights to the tails of a group of rats and had them climb a ladder five sessions a week. Other rats on the same schedule ran on a treadmill, and a third group just sat around. After eight weeks, the running rats had much higher levels of brain-derived neurotrophic factor (B.D.N.F.), a growth factor that is thought to help spark neurogenesis, than the sedentary rats. So did the rats with weights tied to their tails. The weight-bearing rats, like the runners, did well on tests of rodent learning and memory, like rapidly negotiating a water maze. Both endurance and weight training seemed to make the rats smarter.


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Cooking graduation dinner for my sister. What should I make?
I'm going upstate in a couple weeks to cook a graduation dinner for my sister, her friends, and everyone's parents. A group of a couple dozen. It's a mostly outdoors, casual, fun meal as things at my sister's place tend to be. Any suggestions for what I should make for her? For the record, Aya Kristin Alt is my sister, and she's soon going to be a vet!
(Congratulations! You've made something of yourself after all :) And good news for Hambone and Yuba)all
Talk is closed, but that doesn't mean the conversations have to stop!
Check out this post for a more thorough explanation, and jump onto our Facebook page or our Twitter feed to keep the conversations going!


text:
The Washington Examiner's Byron York spoke to Rep. Doug Lamborn, who is spearheading the GOP battle to defund NPR, about his thoughts on the NPR sting video released earlier today.
"I am amazed at the condescension and arrogance that we saw in the sting video," Lamborn told York. "They seem to be viewing themselves as elites living in an ivory tower, and they are obviously out of touch with ordinary Americans."
Lamborn is amazed by this? Has he never tuned into NPR before? He didn't need a sting video to tell him what he could have figured out by listening to All Things Considered for 15 minutes.
There's no doubt that former NPR fundraising official Ron Schiller's statements about politics were offensive and his comments about Zionists and the media were troubling. But other than highlighting that his actions as an NPR executive were unprofessional and inappropriate, these remarks don't tell us much of substance.
The real issue from the video that the GOP needs to focus on is Schiller's statements about how NPR can live without government funding (that is, if Republicans want to give attention to the sting tape at all — which may not be the best move). Lamborn noted in his comments to York: "The real crux of the video was when the guy … admitted that they could survive and would even be better off without federal funding," said Lamborn. "That's what I'm hoping happens."
If Republicans decide to use the contents of the video in their fight against NPR, they will do best to avoid exploiting Schiller's inflammatory statements for political purposes and concentrate solely on the funding issue.


text: Its Dad's Weekend, Senior Day, and a rivalry game against the Huskies. But its also the last chance to tailgate! Want to chat? Find me and other Beavs on twitter during the game! Just search for the #gobeavs hashtag and we'll find you!Here's the live tweets right now!Follow The Beavers On Twitter at #gobeavsGo Beavs! Beat the Dawgs!


text:
N-Terminal Microdomain Peptide from Human Dihydroorotate Dehydrogenase: Structure and Model Membrane Interactions
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N-Terminal Microdomain Peptide from Human Dihydroorotate Dehydrogenase: Structure and Model Membrane Interactions
Protein & Peptide Letters,
22(2): 119-129.
Eduardo F. Vicente, Thatyane M. Nobre-Pavinatto, Felippe J. Pavinatto, Osvaldo N. de Oliveira Junior, Antonio J. da Costa Filho and Eduardo M. Cilli
Departamento de Bioquimica e Tecnologia Quimica, Instituto de Quimica, UNESP—Univ Estadual Paulista, Rua Prof. Francisco Degni, 55 - CEP 14800-900, Araraquara/SP, Brazil.
The N-terminus of the human dihydroorotate dehydrogenase (HsDHODH) has been described as important for the enzyme attachment in the inner mitochondrial membrane and possibly to regulate enzymatic activity. In this study, we synthesized the peptide acetyl-GDERFYAEHLMPTLQGLLDPESAHRL AVRFTSLGamide, comprising the residues 33-66 of HsDHODH N-terminal conserved microdomain. Langmuir monolayers and circular dichroism (CD) were employed to investigate the interactions between the peptide and membrane model, as micelles and monolayers of the lipids phosphatidylcholine (PC), 3-phosphatidylethanolamine (PE) and cardiolipin (CL). These lipids represent the major constituents of inner mitochondrial membranes. According to CD data, the peptide adopted a random structure in water, whereas it acquired α-helical structures in the presence of micelles. The π–A isotherms and polarization- modulated infrared reflection-absorption spectroscopy on monolayers showed that the peptide interacted with all lipids, but in different ways. In DPPC monolayers, the peptide penetrated into the hydrophobic region. The strongest initial interaction occurred with DPPE, but the peptide was expelled from this monolayer at high surface pressures. In CL, the peptide could induce a partial dissolution of the monolayer, leading to shorter areas at the monolayer collapse. These results corroborate the literature, where the HsDHODH microdomain is anchored into the inner mitochondrial membrane. Moreover, the existence of distinct conformations and interactions with the different membrane lipids indicates that the access to the enzyme active site may be controlled not only by conformational changes occurring at the microdomain of the protein, but also by some lipid-protein synergetic mechanism, where the HsDHODH peptide would be able to recognize lipid domains in the membrane.
Circular dichroism, human dihydroorotate dehydrogenase, Langmuir monolayers, peptide, phospholipids, polarization- modulated infrared reflection-absorption spectroscopy, solid-phase peptide synthesis.
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Linked Jazz API
Linked Jazz is a project designed to reveal relationships between jazz musicians using digital archives on jazz history. The project uses Linked Open Data (LOD) technology to uncover meaningful connections in the archived data and reveal the social networks that composed these jazz musicians' professional and personal lives. The Linked Jazz API can be used to search for specific people, return relationship information, and get the raw text for the digital archive transcripts.
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Welcome to Zagor Online
NOTE: For other comics and characters, please click on the following link: Ostali Junaci (Alan Ford, Tex Viler, Komandant Mark, Kapetan Miki, Veliki Blek, Mister No, Marti Misterija, Dylan Dog). For Zagor only please keep scrolling.
Have you ever wanted to own and read ALL Zagor comics? And we do mean ALL. This collection includes 880 of scanned Zagor comics and is the largest Zagor collection for sale on the net.
Completed series of Zlatna Serija and Lunov Magnus Strip!!! Ciko and Zagor Specialci are included too. Plus newer editions: Slobodna Dalmacija, Ludens and Ludens Extra. Scroll to the bottom of the page for detailed list.
All comic are scanned and can be read on any Windows, MAC's, iPhone and iPads. All comics come in CDR format except Lunov Magnus Strip which comes in regular JPG format so it can be read on any Windows PC or a MAC without any special software. CDR format is the most efficient comic book reading format. We will include CDR Player (very small and easy to install) with shipment so you can read it on any windows pc. There tons of comic readers for MAC's , iPads and iPhones out there. You can pretty much use any that supports CRD files.
This collection will deffinitly keep you busy for a while. Call it a nostalgy or whatever you like, but there is something very special about reading all of these Zagor and Ciko's adventures once again. No matter what your age is. It simply never gets old. And the best part is, once you get them, you can read them over and over again and take them with you everywhere you go.
See below for list of all comics included in the package.
|All Zagor Series
|Zlatna Serija
|304 comics - Completed Series
|Lunov Magnu Strip
|42 comics - Completed Series
|6 comics - Completed Series
|7 comics - Completed Series
|120 comics - Completed Series
|Slobodna Dalmacija Extra
|77 comics - Completed Series
|Slobodna Dalmacija
|71 comics - Completed Series
|Horus - Zagor Predstavlja
|2 comics - Completed Series
|Zagor Specijalni Brojevi
|11 comics- Completed Series
|Zagor Vanredni Broj
|4 comics - Completed Series
|4 comics
|Ciko Speciajlni Brojevi
|19 comics
|Ludens - Ciko Specijal
|18 comics
|Ludens Almanah
|5 comics
|Ludens Extra
|98 comics
|Ludens Maxi
|12 comics
|Ludens Speciajal
|35 comics
|Nobjavljeno u Zlatnoj Seriji
|26 comics
|Zagor razno
|11 comics
|Zagor za Kolekcionare
|10 comics


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Motorola DROID Mini
Last Updated: Jul 23rd,2013
The Motorola DROID Mini is an affordable handset with a good punch. It has almost the same features and specs as its bigger brothers (DROID Ultra and DROID Maxx), but all packed in a 4.3-inch display.
Specs include a 1.7 GHz dual-core processor, 2 GB of RAM and Android 4.2. It also features a very resistive and good-looking kevlar build.
(see all)
Home screen auto rotate not working
Jul 11, 2015
Odd digitizer problem
Mar 04, 2015
Assist App causes phone to ring in a strange ringtone.
Jan 24, 2015
Official Motorola Droid Mini User Manual
Jan 19, 2015
What is the difference between the preinstalled "OK Google Now" and "OK Google" from the play store?
Nov 07, 2014
News & UpdatesMotorola says promised Lollipop update is coming 'really soon' to 2013/2014 smartphone lineup
If you own any of Motorola's 2013 or 2014 flagship devices don't give up hope. Motorola says Lollipop is coming "really soon" but only after they make sure it's relatively bug-free.Motorola Migrate update now lets you import contacts from dumbphones
We're not sure how many people will be upgrading from a dumbphone to one of Motorola's latest smartphones (including the Moto G and Moto X 2014), but if you are then we have some good news for you: Motorola Migrate now supports your phone!Verizon posts Android 4.4.4 changelog for all 2013 DROID phones
Verizon and Motorola have confirmed that their DROID devices from 2013 — including the DROID Mini, Ultra and MAXX — will be receiving Android 4.4.4 builds. Changelog awaits you inside.Motorola Connect update finally Brings MMS support
Users of the Moto X and Verizon's DROID phones have a great update to look forward to if they use Motorola Connect to receive and respond to text messages on their Chrome browsers. The app has finally been updated to bring partial support for MMS.Motorola Touchless Controls' "What's Up" command is too awesome for words [VIDEO]
Yesterday, we told you guys about a new upgrade to Motorola's Touchless Controls app that added an awesome new command. Saying "What's Up" or "Read Notifications" will have the phone read back a list of your recent notifications. We gave the new feature a spin on video on the Motorola DROID MAXX running Android 4.4 KitKat, and marveled at the fact that it sounds pretty natural and fluid.Motorola Touchless Control's new "What's Up" command will read your notifications aloud
A new upgrade is headed to the Touchless Controls app on the Moto X and the Verizon DROID Mini, Ultra and MAXX. There weren't a multitude of new features, though the magnitude of the one new feature certainly does excite us. Motorola has added a new "What's Up" command, which will recite your notifications back to you in an oddly-digitized voice.Motorola's Gallery app heads to Google Play with new user interface
Owners of the Motorola Moto X and Verizon's newest DROID phones will be happy to know that the company's gallery app has been put into the Google Play Store. They also too this opportunity to bring us a brand new user interface.Would you buy a Motorola phone if they had early access to Android updates? [POLL]
When Android 4.4 KitKat launched, we were surprised to see that the Moto X got the upgrade before most Nexus devices. It wasn't a huge gap between the rollouts, but the fact that any non-Nexus device got it before any others was astonishing. Some suspected Motorola might have had privileged access to the update. Would you buy a Motorola phone if that were true? Vote in the poll inside!Motorola DROID Maxx, Ultra and Mini KitKat upgrades resume rolling out
It appears a larger group of folks are being greenlit to pull down the Android 4.4 KitKat update they've been craving, with reports from owners of the Motorola DROID Mini, Motorola DROID MAXX and Motorola DROID Ultra telling us that much.Verizon confirms KitKat for DROID phones today
Earlier this morning, we were tipped off to news that Motorola would begin the soak test upgrade for Motorola DROID Mini, DROID MAXX and DROID Ultra users. The company didn't give us any clue as to what the upgrade would be after their last snafu, but our KitKat senses have been tingling ever since we […]


text:
Jeremy Borash noted on Twitter that the finalists of British Boot Camp are in Phoenix, Arizona for this weekend's Bound For Glory festivities. The program, which has been commissioned by Challenge TV and will air in December, will follow four Brits attempting to win a full-time TNA contact.
The finalists are wrestling twins Hannah and Holly Blossom, Marty Scurll and Rockstar Spud.


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About USF
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Environmental Management — Urban Affairs
Paul Craig Okamoto
Adjunct Professor
Paul Okamoto has committed his professional architectural career to designing buildings and neighborhoods in ways that optimize environmental and social conditions. With his San Francisco-based firm Okamoto Saijo Architecture, he designs affordable housing developments, community centers, custom passive solar residences, community-based neighborhood plans, all with an emphasis on sustainable design. He received his Bachelor of Architecture from the California Polytechnic State University, San Luis Obispo, CA, and his Master of Architecture from the University of Adelaide, Australia. He is a 2001 Loeb Fellow at the Graduate School of Design, Harvard University.He is a licensed California architect and a LEED Accredited Professional, and he serves on the Urban Ecology Board of Directors.
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text: « BACK | PRINT RS MEMBER DIARY The Case for Not Wasting $1 Trillion Dollars By: Brian Darling (Diary) | February 10th, 2009 at 04:00 AM | RESIZE: AAA Share on Facebook 1 1 SHARES RedState Gathering All-Access Passes Have SOLD OUT.Register here for the Thu/Sat night Party Pass! Share on Facebook 1 1 SHARES Tags: CATO Institute, stimulus Get Alerts COMMENTSPOSTING RULES | LOGIN TO COMMENT | REGISTER TODAY ADVERTISEMENT REDSTATE COMMUNITY ALL COMMENTS POPULAR #RSRH Harry Reid channels Strom Thurmond: Senate to Vote on #DefundPlannedParenthood By: Steve Berman The Constitution Has a Heartbeat By: dukefergus Can Trump Trump [The Ruling Class]? By: Gregory Brittain With Friends Like These: Cheryl Mills By: davenj1 Planned Parenthood Is Our Auschwitz By: Owen Strachan RNC Committeewoman Demetra DeMonte: I'm As Frustrated As You Are(Video) By: Ulysses Arn 140 House Members are Ready to #DefundPlannedParenthood By: Steve Berman Watch Carly Fiorina knock it out of the park at the Reagan Library By: gawken Defunding Evil is More Important Than Building Roads By: Conrad Close John McCain the Hypocrite By: Kelly R. Burke Planned Parenthood Dehumanizes Its Victims To Abuse Them By: Loren Heal The Donald Trump Rule: 'Flip-Flopping' to the Right Position Can Be a Very Good Thing By: Seton Motley Call for my death? I'll lift your sanctions. Call my deal bad? I'll shut you up. By: Bob Buresh Jeb attracts 'Bush Democrats' with the smell of money By: Steve Berman Ted Cruz Has a 15:1 Advantage Over Jeb Bush With Conservatives… And Why the Establishment Should Care By: imperfectamerica American Lives Matter By: dvdmsr Immigration and "Fundamental Transformation" By: Gregory Brittain If Cosby, Why Not Clinton? By: davenj1 Marita Noon: Obama: Iranian oil, good. Canadian oil, bad. American oil, bad. By: Marita Noon Planned Parenthood Knows Babies Are Priceless By: Kelly R. Burke Ted Cruz Was Right: GOP Senate Majority Vote With Obama at a Record Pace By: Candice Lanier The "Consider This" Podcast; Legal Discrimination, Black Votes Matter, and France Surrenders By: Doug Payton The Coming World War That Will Be Triggered In The Middle East By: mermerus New York Minimum Wage is Absurd and Discriminatory By: Paul Jensen Chris Farley Government: Remember When It Was Congress That Made Law? That Was Awesome By: Seton Motley IMPORTANT! UPDATED 7/27: Preibus, you dumb ass: Did you hear what Trump just said? "I identify with some things as a Democrat" By: gawken Team Scott Walker rams winner take all primary down NC's throat By: helmsconservative Donald Trump: Troll, Mole, Both, or Neither? By: davenj1 Which One is the 'Drag Queen'? By: Steve Berman The Bernie Factor By: davenj1 Grassley Plants Seeds for Corporate Cronyism By: dukefergus Hail to the Blue Dwarfs By: Steve Berman Preibus: "I don't think (er…I hope) Trump won't run as a third party candidate." Describes his job as "herding cats." By: gawken Minimum Wage, Immigration and the Price of Labor By: Gregory Brittain Getting The Words Of Jesus Straight On Gay Marriage By: Thomas A. Howe, Ph.D. So Who Cares If Babies Get Crushed By: mermerus Why We Can't Have Mental Health Checks on Gun Owners By: Paul Dragu mitch HAS GOT TO GO!!!!!! By: alphacon1963 My Proposals for a Possible Constitutional Personal Weapon Amendment By: brian1958griffin ACLU-NH's selective First Amendment defense By: Ellen Kolb moelane: #rsrh This Minnesota Lt. Governor / @PPAct story needs further research, I think.: http://t.co/nrHqofzQqkstreiffredstate: RT @moelane: #rsrh The wicked and vicious plot by LIBRE to oppress Hispanics by having them get GEDs.: http://t.co/ibq3ykCLQbBrianFaughnan: RT @moelane: #rsrh The wicked and vicious plot by LIBRE to oppress Hispanics by having them get GEDs.: http://t.co/eDSQLUJ00mmoelane: #rsrh The wicked and vicious plot by LIBRE to oppress Hispanics by having them get GEDs.: http://t.co/eDSQLUJ00mmoelane: #rsrh Don't be afraid to get it wrong.: http://t.co/OXU4diqyI4moelane: #rsrh Secularists continue their Magical Tin-Ear PR Tour in Detroit, Michigan.: http://t.co/1pAEuXZHkXmoelane: #rsrh Tweet of the Day, Who Wants Some Good News in FL-SEN? edition.: http://t.co/yfIJXdPXEDmoelane: #rsrh So this is sort of my mood, right now.: http://t.co/9fjDIMNM9umoelane: #rsrh Vine of the Day, Я клянусь, это никогда не случалось со мной прежде edition.: http://t.co/9dEi6pxCVDmoelane: #rsrh Quote of the Day, Just Memory-Hole The Whole Democratic Party, Then edition.: http://t.co/e85MeiqpeUmoelane: #rsrh "And A Big Yellow Taxi Took My Young Professionals Voting Bloc Away..." Hmm. Doesn't scan.: http://t.co/sjpVBTLutsmoelane: #rsrh Did you miss Clintonian-level language parsing? You didn't? Sorry to hear that, because it's back.: http://t.co/8C4txf3GzjAaron_RS: RT @moelane: #rsrh First of two stupid felony indictments against Rick Perry just ejected from court.: http://t.co/kLJo5zsdVh REDSTATE LOCAL PICK YOUR STATE & GET LOCAL SELECT A STATE Register Today for the 2015 RedState Gathering ADVERTISEMENT


text:
Favorite Office Time Wasters
Richard Marini finds the best and the brightest distractions.
Posts filtered on Tag
Answers to the name, "Lucky"
Australian TV profiles a man who had an accident at work, had a heart condition was near death, and then wins 250,000 dollars on live TV.
Think you're unlucky because you've never won the lottery? Think again.
You've already won the biggest lottery of them all:


text:
TerraMaster F2 NAS
Attractive design. Nice handle on top. Decent Read/Write performance.
- Cons Can't tell progress of RAID build upon initial setup. Can't see firmware update applying. Power button wouldn't shut unit off a couple times. Lacks some business features.
Bottom Line
This attractively-designed NAS has a clean, simple interface and decent performance but it has too many issues with initially creating RAID, the power button, and firmware updating—it's just not a recommended device.
TerraMaster F2 NAS
|Device Type: Expandable SMB NAS
|Operating System: Embedded Linux
|Maximum Storage Capacity: 6 GB
|Rack-mount or Standalone: Standalone
|Hard Disk Configuration: RAID
|JBOD/RAID Disks: 2
|RAID Level: RAID 0, RAID 1
|Network Medium: Wired
|External USB Hard Disk Expansion: Yes
|UPnP Capable: Yes
|Printer Server: Yes
|Media Server: Yes
|Remote Access: Yes


text:
11/22/2011 | Fall Section Manager Election Results
ARRL members in New Mexico, Tennessee, and Michigan will have new Section Managers, beginning January 1, 2012. Members in Kansas also re-elected their Section Manager in a balloted race that concluded when ballots were counted and verified at ARRL Headqua
Learn More
11/18/2011 | Delta Division Sees Leadership Change; Midwest, Atlantic Divisions Unchanged
On November 18, ballots were counted in the races for Director in the Atlantic, Delta and Midwest Divisions. This year, there were only three contested races for Director or Vice Director in the five Divisions holding elections. In the Delta Division, Vic
Learn More
10/21/2011 | Former ARRL Midwest Division Vice Director C. Richard Dyas, W0JCP (SK)
Former Midwest Division Vice Director C. Richard Dyas, W0JCP, of Oxford, Nebraska, passed away October 17. He was 90. Dyas -- a Charter ARRL Life Member -- was first elected Vice Director in 1975 and began his term on January 1, 1976. He resigned in 1985
Learn More
08/25/2011 | ARRL Members Nominate Candidates for Director, Vice Director
The policies of the ARRL are established by 15 Directors who are elected to the Board on a geographical basis, with elections for three-year terms held in five divisions each year. At the same time, Vice Directors are elected on the same basis. Responding
Learn More
07/07/2011 | 2011 Second Meeting of the ARRL Board of Directors Set for July 15-16, Agenda Announced
ARRL policy is made by its Board of Directors. The 15 voting members of the Board are the Directors who are elected by the ARRL members in their respective divisions. The Board meets in January and July, usually in the Hartford area. ARRL members also ele
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02/07/2011 | ARRL Board Sets Legislative Agenda at 2011 Annual Meeting
The ARRL Board of DIrectors met in Windsor, Connecticut January 21-22, 2011
Learn More
02/01/2011 | ARRL In Action: What Have We Been Up to Lately?
ARRL In Action: What Have We Been Up to Lately?
Learn More
01/28/2011 | Former Northern New Jersey Section Manager Appointed Hudson Division Vice Director
After review of eligibility by the ARRL Ethics and Elections Committee, President Kay Craigie, N3KN, has appointed William W. Hudzik, W2UDT, of Gillette, New Jersey, to serve as Vice Director of the ARRL's Hudson Division for the remainder of the current
Learn More


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Drug investigators searching a downtown Charleston home Thursday night said they found a backpack full of drugs and a baby stroller carrying a stolen Smith & Wesson.
They arrested Harvey Ricardo Wiggins, a 23-year-old felon with a storied past, on seven drug and firearms charges. His girlfriend, who rents the apartment in the Charleston Housing Authority building at 20 Magazine St., said Wiggins "has not had a legal job ever since he was released from prison," according to police reports.
The Adams Run resident, who stays several nights a week at the apartment two blocks north of Broad Street, had served time behind bars for threatening the life of a public official, assault and battery of a high and aggravated nature and unlawfully carrying a weapon.
Those convictions stemmed from separate cases in 2009 in which Wiggins shot at a Charleston County Sheriff's Office deputy. During a traffic stop months later when authorities found marijuana and $800 worth of cash in his car, he told a deputy, "I'm gonna make it my life's mission before I die to see you go down," according to a report.
But Wiggins' troubles started at an early age.
When he was 13, he and some other children in Parkers Ferry were shooting a BB gun at a .22-caliber cartridge they had found. When a BB hit it, the round exploded, and the shell casing lodged in Wiggins' head.
Wiggins still has a scar from the wound a decade ago, according to an arrest report.
When he was 17, Wiggins participated in the Beaufort Marine Institute, which aimed to divert troubled teenagers from the path to prison. The young Wiggins said in an interview at the time that he had an attitude problem and that the institute taught him self-control.
As he stood in jail garb during his bond hearing Friday, Wiggins sighed and held his face in his hands as Magistrate Linda Lombard read about his history and the new charges against him.
"I'm looking at some bad records," Lombard said.
Lombard set his bail at $500,000 on charges in connection with the possession of marijuana and cocaine and the distribution of those drugs near a school. He also faces counts related to being a felon possessing a stolen firearm.
"That's crazy," he told the magistrate. "A person ain't never seen that much money in their life, and ya'll give us a bond like that."
Lombard said "that's enough" as Wiggins continued calling the bail amount "crazy."
"These aren't average times," Lombard said, "and we aren't dealing with average people."
The Charleston Police Department was led to the Magazine Street apartment after an informant bought 4 ounces of marijuana from Wiggins earlier this week, according to arrest affidavits.
In the kitchen, officers found Wiggins' backpack that contained 6.6 ounces of marijuana and 0.18 ounces of cocaine, reports stated.
They also came across $300 in cash and a loaded .40-caliber Smith and Wesson pistol that had been stolen from a Dorchester County resident in 2011.
Reach Andrew Knapp at 937-5414 or twitter.com/offlede.
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