text: The Joe Danger wiki last edited by ReverendHunt on 04/13/15 06:53PM View full history OverviewGame logoJoe Danger is the first game from Hello Games, and was released on the PlayStation Network June 8th, 2010 in the US and June 9th in Europe.The Xbox 360 version was released on the Xbox Live Marketplace more than one year later, on December 14th, 2011 as Joe Danger: Special Edition.The developers also released it on the PC in 2013 and Playstation Vita in September 2014. A sequel was released in 2012 named Joe Danger 2: The Movie.GameplayDo stunts, earn pointsThe titular Joe Danger is a famous stunt driver and daredevil. Controlled by the player, he can drive both forward and backwards, with the ability to control the speed and direction of the motorcycle, even in midair. Joe can also perform a small hop, to jump over obstacles or jump off ramps and springs for extra height.Using the height gained from ramps, springs, and other obstacles, the player can also perform a variety of stunts before touching the ground. Stunts can be strung together into a combo either by preforming several stunts in the air at once, or preforming a wheelie or endo after touching the ground, or a combination of both. Performing stunts will also fill a boost meter, which can be used when fully charged to provide a temporary speed boost.The levels in Joe Danger consist of three parallel lanes, each with a variety of obstacles, which can either help or hinder progress through the course. Ramps, springs, fans, and boost pads all help by giving either more height or speed, while spikes, shark tanks, mouse traps and the dreaded horizontal bar all serve to make the ride more perilous. Lanes can only be changed at lane change switches, making which lane choice strategic for completing certain objectives.Collect all the coins!Each level has one main objective and at least one secondary objective. The main objective is tied to the rating for the level (gold, silver or bronze). The most common main objective is getting a high score, which is achieved by preforming stunts. More points are awarded for stunts that take longer to complete, for holding the stunt for as long as possible without crashing, and performing as many stunts as possible in a single combo (with each stunt adding to the score multiplier). Other main objectives include landing on targets placed around the course (simply driving over them doesn't count), collecting as many coins within a certain time limit, knocking over bowling pins with Joe 'ragdolling' after crashing, or competing in a race with other drivers.One of the race objectivesThe secondary objectives for each level are tied to stars, which are used to unlock additional levels. Secondary objectives range from landing on targets, collecting coins, knocking over bowling pins, and finishing first in a race, assuming they aren't the main objective, and other goals such as collecting ministars, completing a level or another objective before a set time limit, completing a level or objective while maintaining a combo through the entire level, collecting the letters D-A-N-G-E-R, and lastly, finding stars hidden in the course.Career ModeThe main game mode consists of ten tiers, each with a different set of levels that you unlock progressively.Don't get eaten by a shark!Stunt WeeklyTeam NastyComeback TourHigh VoltageExplosive TourShock HazardCrush ZoneThe Danger ZoneMaster of DisasterGrand FinaleMap EditorJoe Danger also includes a map editor. Every object that was available to the developers is available for the player to build a course. One can also include any objective that is available in the main game in their custom level. Custom levels can be shared via friends on the PlayStation Network, or, as of a recent update, on the Hello Games website.PS3 UpdateIn August 2010, Hello Games released an update for Joe Danger called the "People's Patch". Users can download levels from Hello Games' website, instead of having to share with friends only. Users can also upload their levels for anyone to enjoy. A USB stick is required to move the levels between the console and computer.Levels can be uploaded/downloaded here.Other new features include:Replay saving, and uploading to YouTubeCustom music (play music on your hard drive as you play the game)Added multiplayer levelsEven more level editing propsCostumes, including a monkey suitNew ToursHidden secretsSpecial EditionThe XBLA version released in December 2011 titled Joe Danger: Special Edition features added content, including new environments, characters and gameplay modes, such as new Challenge mode: 'The Laboratory'. At Christmas it also received a free Santa downloadable costume for Joe.System RequirementsOS: Windows® 7 (32/64-bit)/Vista/XPProcessor: 2.0Ghz Dual core processorMemory: 1 GB RAMGraphics: DirectX 10 compatible GPUDirectX®: 10Hard Drive: 700 MB HD spaceAdditional: Microsoft Xbox 360 Controller or Direct Input compatible controller


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Tickets: £8, £5 concessions, £3 students
Book in person at the Barber Reception Desk or by calling the Box Office on 0121 414 7333.
The University Wind Band plays a selection of film music and works by Walton, Stravinsky and Adams. The Brass Band will perform works well known to all brass band aficionados, including Eric Ball's Salvationist tone poem The Kingdom Triumphant and Peter Graham's Summon the Dragon.
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Posts Tagged «xbox smartglass»
The Xbox One's most puzzling missing feature: Remote play November 20, 2013 at 9:22 am
Microsoft's Xbox One debuts today, but true PC – Xbox integration remains elusive, even though the two products are more alike than ever. How much longer do we have to wait for a game streaming solution between Microsoft's divisions?
Looking through the Xbox SmartGlass June 5, 2012 at 9:52 am
An evolution of the existing Xbox Companion app for Windows Phone 7 and Windows 8, SmartGlass will allow users to interact with the Xbox using any smartphone or tablet. Devices with SmartGlass technology can share media, control the Xbox, act as a secondary display for games, and provide and a touchscreen controller for the upcoming Internet Explorer browser for Xbox.


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DressUpGamesX.com now offers an extensive range of complimentary dress-up games online for engaging the fashion-savvy gamers, and allows them to express their creativity in a seamless way.
(businesspress24) - USA DressUpGamesX.com is one of the leading gaming websites on the internet with a great reputation amongst the online gamers. The website now brings a host of free dress-up games online to the fashion-savvy gamers.
Check out the whole collection of games at dressupgamesx.com
Few of the most-played games on this website are Barbie Bride Dress Up, Barbie Rockstar, A Relaxing Sunny Day for Barbie, and almost every other Barbie game on their list. Besides Barbie games, there are many more exciting games like Manga Fairy, Queen of Vampire, Lovely Christmas Doll Dress, and more.
The website owner spoke about the new games at a press meet and was quoted as saying -DressUpGamesX.com is a website that offers several dress-up games for girls and you can be 100% safe on our site. We understand the vast influence that such games have on the imagination of girls today. It is crucial that the characters in the game resemble the things they recognize like cartoon characters and dolls. So, they feel safe and can express their creativity easily.
Aspiring fashionistas can play various fashion games on DressUpGamesX.com by being stylists for the animated models. They get to choose from various clothes and fashion accessories with the fashion possibilities being almost endless. All the games are easy to play for kids and feature attractive character and fabric designing. Confronting these fashion challenges lets the girl gamers to progress in their fashion dreams.
The product manager of the company stated We have taken the likes and dislikes of different kinds of gamers into consideration for designing each of the dress-up games on our list. Enjoy and play the best hand-picked online games here for endless fun and entertainment.
Those interested in dress-up games can play them for free on DressUpGamesX.com, and have gala of a time without spending a penny.
About DressUpGamesX.com
DressUpGamesX.com is one of the popular online dress-up gaming websites with a vast collection of interesting games. It now offers extensive variety of free dress-up games online.
Log on to dressupgamesx.com for more info about the various games offered to the gamers.
For media inquiry
Contact name: Rob
Phone: +1 3239827667
Email: support(at)dressupgamesx.com
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Datum: 17.03.2014 - 13:28
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Tags techno, deep house
Artists Pan-Pot, SCSI-9, Donnacha Costello
December 22, 2011
Some deep, delicious and shiny tracks courtesy by Korablove, SCSI-9, Pan-Pot and others great Techno producers
More Music: http://www.facebook.com/TrackADay
One of the hidden beauties on 8tracks!
Sometimes we need to disappear by yawmindj
Rediscovering Ambient, Dub, Downtempo, Deep and Elegant Music.
deep house, ambient, dub techno, glitch, downtempo
Darker by yawmindj
Turn off the lights and play it loud.
techno, minimal techno
Deeper by yawmindj
Not intended for dancing, just for listen.
deep house, techno, minimal
Spectral sounds by yawmindj
10 tracks with a touch of darkness and suspense; i think i can call this mix 'Spectral Sounds'.
minimal techno, techno


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Limits Lifted On Political Donors
Professor Nate Persily weighs in on the U.S. Supreme Court decision in McCutcheon v. Federal Election Commission and how the "battle to keep money out of politics" has already been lost.
The U.S. Supreme Court's 5-4 ruling Wednesday, striking down limits on the total amount wealthy individuals can give to federal candidates in an election cycle, means more money in a political system already awash in it.
But it may also mean more transparency, because the extra money will flow to politicians who have to reveal where it came from.
Four years after the court opened the door to unlimited political spending with its Citizens United decision, "it is much better to rewrite the balance and let accountable institutions - parties and candidates - compete with shadowy groups" like so-called social-welfare organizations and the umbrella groups known as super PACs, said Nathaniel Persily, a Stanford University law professor.
But Persily said the legal battle to keep money out of politics has already been lost. Advocates will have to try to limit the damage through such measures as stronger disclosure laws and more public funding of campaigns, the Stanford professor said.


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This WordPress plugin is a complete flexible Projekt Task Management System. It's a very easy to use, but yet a powerful plugin.
No reviews yet! Be the first to review this plugin!
You must log in to submit a review. You can also log in or register using the form near the top of this page.


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Time Magazine Cover Features "King Bibi"
Lead story of May 28 issue devoted to Israeli Prime Minister Benjamin Netanyahu
By: Sammy Hudes
Time Magazine's lead story in its upcoming May 28 issue will profile Benjamin Netanyahu, as the Israeli Prime Minister is featured on the front cover of the publication under the headline, "King Bibi."
Written by Time Managing Editor Richard Stengel, the article, titled, "Bibi's Choice," explores the difficult decisions that Netanyahu will have to make in his efforts to secure the future of Israel, according to Ynet.
Underneath the front page headline, a subheading reads, "He's conquered Israel, but will Netanyahu now make peace – or war?"
"To be a historic figure, one must make history," writes Stengel.
"Now we will find out what the king really believes. Is he a statesman or a pol, a builder or a general, the Israeli leader who can finally make peace with the Palestinians or the one who launches a potentially disastrous unilateral attack on Iran."
Stengel states that Netanyahu "is poised to become the longest-serving Israeli Prime Minister since David Ben-Gurion, the founding father of Israel. He has no national rival. His approval rating, roughly 50 per cent, is at an all-time high."
The eight-page, approximately 5,000-word article discusses the Iranian nuclear program and Netanyahu's skeptical attitude toward the Palestinian leadership's readiness to enter peace negotiations, according to The Times of Israel.
In Time's online blog, which discusses the article's range of topics, Netanyahu is described as a "controversial" leader who in the past month "cannily consolidate[d] power, brokering a coalition that pairs his Likud party and other right-wing allies with the more centrist Kadima."
Time writes that "the deal deflects calls for fresh elections and gives him a virtual lock on Israel's top job going forward."
With a now-stable political position, the author ponders whether Netanyahu will be able to turn himself into a "historic figure" by making peace with the Palestinians.
Stengel says that the longer he spoke with Netanyahu, the greater impression he got that the Israeli Prime Minister does not believe the Palestinians are interested in peace or capable of democracy.
"If they figure it out, they will never have a better partner than me. I can make it happen and make it stick," Netanyahu stated about the peace process with the Palestinians.
"Under his watch, the peace process has gone moribund — which compelled the Palestinians to break away from talks and take their cause to the floor of the United Nations General Assembly last year," according to Time, which also calls Netanyahu's stance on Iran "a hawkish pose that flies, sometimes, even in the face of the intelligence analyses of his own officials."
According to The Times of Israel, "Bibi does not share the general faith in negotiations or give any ground on the military option," Stengel notes.
"There's a greater threat in doing nothing, he says, than in acting. Game theory would also suggest that there is no downside to Bibi's bluster. But he gives no hint that he is anything but dead serious."
Stengel writes that the choice is Netanyahu's to decide "whether he is a prisoner of history or can write a new narrative."
Anti-Violence Rallies Taking Place Across Israel TodayAugust 01, 2015 | By Noam 'Dabul' Dvir, Roi Yanovsky, Ahiya Raved, and Gilad Morag
Following two blood-soaked days, in which a Palestinian infant was killed and his parents and sibling were critically wounded in a fire and six people were hurt in a stabbing at Jerusalem's gay pride parade, thousands are expected to protest in Tel Aviv, Jerusalem, and Haifa
Report: 53% Rise in Anti-Semitic Incidents in the UKAugust 01, 2015 | By B. Shane Morganstein
Government officials are speaking out against anti-Semitism after new report finds rapid increase in anti-Semitic incidents
Film to be Made about Jonathan PollardAugust 01, 2015 | By B. Shane Morganstein
The American jailed for passing sensitive information to Israel will have his story adapted for the big screen
Over 100 Jewish Gravestones Toppled in PhiladelphiaAugust 01, 2015 | By Maria Cruz
Some of the headstones date back 160 years
Woody Allen Speaks Out About NetanyahuAugust 01, 2015 | By Maria Cruz
The director thinks the Prime Minister's decision on Iran deal could be "foolish"
WATCH: Jon Stewart Addresses Uproar over his "Secret" Meeting with President ObamaJuly 30, 2015 | By Daina Goldfinger
"Something is not a secret just because you don't know about it"
Canadian Couple: Killing Young Jews Will Save Them from HellJuly 30, 2015 | By B. Shane Morganstein
The couple, convicted of trying to bomb the British Columbia Legislature, hoped to save Jews from growing up and going to "eternal hell"
WATCH: Viral Video of Israeli Father Shaving his Beard for First Time in 14 YearsJuly 30, 2015 | By B. Shane Morganstein
People are going crazy for this family's reaction to a man named Mooki shaving his beard
The Ten Most Famous Jewish Porn Stars Culture » Society » News


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Kaylin Garcia is another new face on Love And Hip Hop, and she certainly caught our eye at the premiere party when she showed up rocking a fauxhawk and a sexy red blazer with some strategically placed double-sided tape (we assume) holding it in place. After finding her on Instagram though, a few things are very clear about Kaylin:
1) She and Joe Budden are very much in love.
2) She is very beautiful and has no problem showing off her killer body.
3) This is a woman who changes hairstyles almost as frequently as K.Michelle.
Kaylin's said in the past that the mohawk is her "signature look," and she wears it well, but here are some of our favorite other looks that Kaylin's rocked through the years.


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The 17-year-old accused of killing a popular teenager last month broke into his house, went into his bedroom with a kitchen knife and stabbed him while he was sleeping, according to investigators.
Terrell Smith, 17, is accused of murder in the death of 18-year-old Brandon Bennett of Charleston.
Bennett's father told a judge on Thursday that Smith had been to the house several times and he thought the two teens were friends.
"He has been to my house," Bennett told Magistrate Linda Lombard at Smith's bond hearing. "He has eaten my food. I've shown him love. He has played games with my son."
Brandon's mother, Latrease Bennett, also spoke to the judge.
"I would like to know why he had so much hatred in his heart to murder my son," she said.
"I cannot ask him that question, ma'am," Lombard said.
About two dozen of Brandon's friends of relatives were in the courtroom. About 200 of them showed up for a vigil at Waterfront Park after he was killed.
His friends said he never caused any trouble and had never been arrested. He was attending Trident Technical College.
When Bennett was killed, Smith was out on bail after a March arrest for narcotics, according to court records.
Police previously gave Smith's address as Audubon Avenue in North Charleston, but he told Lombard he lived on South Tracy Street in Charleston. That's just a couple blocks from Bennett's house on Congress Street.
Lombard could not set bail on a murder charge. She denied bail on Smith's other charges, which are first-degree burglary, attempted murder and possession of a weapon during the commission of a violent crime.
Police said Smith cut a window screen to enter Bennett's house at about 7:51 a.m. June 11. Smith stabbed Bennett several times with a kitchen knife while he was in bed sleeping, according to the arrest affidavit.
Bennett's father witnessed his son being stabbed, and Smith also attacked him, according to the affidavit. Bennett told police he chased Smith out of the house and returned to find his son sitting in a storage room off a back bedroom. Brandon was pronounced dead at 8:21 a.m. at Medical University Hospital.
Smith was arrested June 16 in Alabama and brought back to Charleston earlier this week.
Reach Dave Munday at 937-5553.
- Keywords
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This article applies to 123-reg Mailboxes
After changing your mailbox password, you may find that you cannot send email from your iPhone or iPad. This is because you will also need to update the password for the SMTP server.
Enter your settings, and select the Mail, Contacts and Calendars.
Select the email account you wish to edit.
Under the IMAP heading, select your account.
Scroll down to the Out Going Mailserver section, and select you SMTP account.
Select your Primary Server SMTP details. This should be smtp.123-reg.co.uk.
Here you can update your password to match your new one, allowing you to send emails again.
Watch the content of this article for changes.


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@ Soulece: DAoC had a classic, targetting based combat system. If you wanted to attack someone or cast a spell at someone you had to click and select your target with the mouse. Also it had autoattacks and white hits. Furthermore it had a really unique interrupting system: If someone was casting a spell and was hit with anything during it (debuff, nuke, melee hit, whatever) the spell was instantly interrupted.
All of this made for a very structured and tactical combat system.
ESO is quite different here: It will be a lot faster and chaotic and won't have the same tactical depth. I'm not saying that's a bad thing per se, it's just different.
And yea, I guess we have to wait and see how things will be once the game is released or an open beta is announced.


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Mohammed Nabil Mahdi
Translator/ Polyglot
Telephone: 002-01288488191
Work experience:
1- Freelance translator.
- Currently working with various agencies and direct clients, in different specializations (literary-Medical-Educational- alongside Legal and Business documents).
2008- Present.-
2- In-House translator
Middle East Protection & Indemnity (MEPANDI), member of Rafimar Group, (EJSC).
Mepandi is a leading Marine Legal Protection and Indemnity firm and a correspondent to several prestigious P&I Clubs (http://en.wikipedia.org/wiki/Protection_and_indemnity_insurance) around the world. We handle court cases for several of the world's top shipping lines, among which are CMA, China Shipping, UASC…etc. MEPANDI is a member of Rafimar Group, http://www.rafimar.com/, one of the top companies working in the field of Marine Multimodal Transport in Egypt.
1- Translating English/Arabic-Arabic/English documents to facilitate official use for MEPANDI's legal team; outsourced attorneys, and clients.
2- Translating business and other texts into Arabic and vice versa.
3- Handling multiple e-mail accounts and other correspondences.
4-performing legal works as a part of the legal department team.
-1/5/2011 -present
Linguistic skills
Mohammed Nabil Mahdi


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Register now for free, or sign in with any of these services:
Want to set your local edition?
Select an edition for more focused local news coverage when you visit NOLA.com.
Don't worry. You can change this setting at any time to another local edition.
Because most New Orleanians have a fascination with all tropical weather systems, no matter where they hit.
Oops. Thanks for catching that. All fixed, now.
Oops! Thanks. Corrected, now.
That's a tough quiz! But a good one. Thanks!
Way nice piece. Thanks.
oops. Right you all are. It's the old Florida complex. Thanks for pointing that out.
The link to the lawsuit is in the first paragraph, but here it is: http://media.nola.com/crime_impact/other/theriot%20lawsuit.pdf
Thanks for pointing this out. It's not a matter of not being proofread. It's a coding issue we're working on.
louiseknows, Everything about French 75 is special, I agree. I haven't tried Bar Tonique; thanks for the tip!
Sorry! Old habits die hard. AP used to insist on the use of 'innocent' and 'guilty' but the brain trust at AP recently changed its mind. Thanks for the catch.
Yikes, sorry about that, folks. All fixed now.
Try this one: http://media.nola.com/hurricane_katrina/other/landrieu-list-projects.pdf
for Mator Mitch Landrieu's 100 projects
Sorry, tulane 81, You're right. We've taken it down.
Actually, TheSixWardGhostWontDie2, yes, we did refer to Laura Bush as 'Bush' on second reference (and still do, in stories about her today). The Times-Picayune doesn't use the term 'first lady' because we consider it to be archaic, too old-fashioned a term for today's presidential family.
Oops! Thanks for the catch. Uncomfortable typo....
herzleid, you need to read the update. I think it might answer your questions: http://www.nola/crime/index.ssf/2010/09/gun_at_galatoires_belongs_to_l.html
Typo in headline is fixed; thanks for catching that. And some technical issues are resulting in some words running together. Hopefully, that will be corrected soon.
Yikes! I thought it might be a nice break from death and taxes. Now, back to taxes ... Kenner mayor proposes new property tax is now lead item
Click the "view full size" type and it should be large enough to read
Dear NOLA.com readers: We are moderating this comment stream and want to provide everyone with a link to our user agreement, which you all agreed to when you registered names on the site. If you are unclear on what is appropriate to post, please take a moment to read the terms again. We encourage all voices and opinions to join the discussion on important topics in our community, and expect them to do so with a degree of respect and civility. We hope you will find a review of the user agreement helpful. Thank you.


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Mon.-Fri. 9am to 5:30pm ET
Unlike some other humidifiers, the warm mist humidification dispensed by the Vicks Germ Free Humidifier or previous Slant Fin Humidifier contains no fine white mineral dust that comes from hard tap water. Use of a Mineral Absorption Pad placed in the bottom of the humidifier's hot water reservoir traps and absorbs hard minerals inside the reservoir before warm mist is released in the air. Use of the Absorption Pad prevents the hard scale buildup that can otherwise shorten the life of your humidifier.
Sold in economical package of 6.
Sold in economical package of 6.
Pads generally last 2-4 weeks depending on hardness of your water.
- Absorbs minerals from hard water
- Prevents white mineral dust in humidified mist
- Stops hard scale mineral buildup inside your humidifier
- For all Enviracaire, Slant Fin and Vicks Humidifiers except 100 and 211D series
- Available in package of 6


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Stuffed Okra/ Bharwan Bhendi Recipe
Published On 11 Nov 2011 By redchillies. Under Dry Vegetable Dishes, Easy Vegetarian Recipes, Indian Vegetarian Side Dishes, Low Fat Recipes.
Be it the stuffed eggplant/brinjal (bharlele vaingan), stuffed capsicum, stuffed karela there is something interesting and special about these recipes. It gives one a feeling that lot of time and effort has been put while making the dish. Having grown up in a Konkani household, most of the stuffing that I ... Read More
Spinach Pithla
Published On 18 Oct 2011 By redchillies. Under Breakfast/ Brunch /Tiffin Varieties, Dry Vegetable Dishes, Easy Vegetarian Recipes, Indian Vegetarian Side Dishes, Low Fat Recipes.
Pithla is spiced gravy made out of Besan (Chickpea flour). It is a quick recipe to have on hand when you are out of vegetables or want to cook something quick and easy. The combination of Pitla Bhakri or Jhunka Bhakri is famous in North Karnataka and parts of Maharashtra. ... Read More
Lettuce Salad with Thai Peanut Sauce Dressing
Published On 27 Sep 2011 By redchillies. Under Easy Vegetarian Recipes, Low Fat Recipes, Pasta Salads & Soups.
Next to Indian, the cuisine that we heart is Thai cuisine and we visit different restaurants often. Each restaurant has its own specialty be it Pad Thai, Thai ginger curry rice, sweet sour vegetables, basil noodles etc that we love. There is this one restaurant that makes an awesome peanut ... Read More
Instant Besan Dhokla/ Khaman Dhokla Recipe
Published On 22 Sep 2011 By redchillies. Under Appetizers / Snacks, Breakfast/ Brunch /Tiffin Varieties, Easy Vegetarian Recipes, Light Vegetarian Lunches, Low Fat Recipes.
Khaman Dhokla, a Gujarati traditional dish is a savory snack made out of gram flour. It is steamed (not deep fried) and is typically served during breakfast or dinner. Since it is made out of chickpea flour it is rich in proteins and carbohydrates. Soft, spongy and delicious they also ... Read More
Indian Flat Beans Curry/ Chaprada Avere Palya/ Papdi ki Sabzi
Published On 17 Sep 2011 By redchillies. Under Easy Vegetarian Recipes, Indian Vegetarian Side Dishes, Karnataka Recipes, Low Fat Recipes.
Indian Flat beans are referred to as chapparada avare in Kannada and as Chikkudu kaya in Telugu, Val papdi in Guajarati. In Bangalore where I grew up, these beans were readily available and my mom used to prepare it often. But here in the US they are not readily available ... Read More
Spring Berry Salad
Published On 13 Sep 2011 By redchillies. Under Easy Vegetarian Recipes, Light Vegetarian Lunches, Low Fat Recipes, Pasta Salads & Soups.
Call this the spring salad or even summer salad, or any other name of choice but this is good for any day of the season. One glimpse of this vibrant colored salad is enough to brighten my mood and cheer me up. I would not mind eating this every day, ... Read More
Dry Mushroom Curry/Mushroom Fry Recipe
Published On 08 Sep 2011 By redchillies. Under Dry Vegetable Dishes, Easy Vegetarian Recipes, Indian Vegetarian Side Dishes, Kid Friendly Recipes, Low Fat Recipes.
Growing up, mushroom was a rarity and something that did not get cooked often in our kitchen. But after living in the US for a while, I have developed an acquired taste to it and now beginning to like it. On the other hand DH and the kiddo have had ... Read More


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Location: Madrid, Spain
Majors: Art, Chemical Engineering, Chemistry, Civil Engineering, Communication Studies, Computer Engineering, Criminal Justice, Cultural Anthropology, Economics, Education, Engineering, Graphic Design, Journalism, Political Science
The co-op opportunities listed on this website are available for Academic Year 2011 - 2012 and are representative of the opportunities available for the upcoming co-op cycle. However, because co-op opportunities change according to co-op cycle, some jobs listed on this site may not be available at this time. Students are highly encouraged to search for jobs on COOL, and/or contact an international co-op counselor for more up-to-date opportunities.


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Philip S. Miller
Castle Rock Genealogical Society [1]meets the third Saturday of every month from 10 am – Noon. Adults welcome.
Castle Rock Writers Workshop Group is an encouraging place to share ideas and manuscripts with other writers on the first and third Thursdays of each month from 7-9 pm. For more information, contact Alice at 303-521-8615 or Tania at 850-259-8642.
Castle Rock Chess Club meets every Monday at 6 pm. The Club is facilitated by Herb Simpson. Adults and Teens of all skill levels are welcome, and no registration required.
Douglas County Garden Club meets the first Tuesday of every Month at 1 p.m.


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High-Flo air regulator and push to connect couplers for less pressure drop, Only 34 lbs for easy portability
Standard Equipment: Compressor, High-Flo air regulator and push to connect couplers, 13-Piece Accessory Kit - includes 25' nylon hose, blow gun and attachments, tire chuck, tire gauge, quick coupler, plugs and Teflon tape
The Porter Cable C2002-WK is an oil-free 1.5 HP running pancake-style air compressor. The induction motor provides longer life and better performance. This motor has replaceable brushes for that will help extended life motor even further. The 150 PSI max pressure allows for longer tool run time. This unit also is able to run at 3.5 SCFM for faster tank recharge of 6 gal tank. The C2002-WK features a 120 PSI cut-in pressure that provides 30 PSI "Bonus Air" before a 90 PSI tool becomes inoperable. The oil-free pump allows for maintenance-free use as well as use on slopes without the risk of oil leakage. At 34lbs the C2002-WK is lightweight for portability, yet this compressor has plenty of power to fire all brad and finishing nailers as well as moderate usage of roofing and framing nailers.
2.6 SCFM delivered @90 psi pump, 6.0-gallon tank and 150 max psi. Durable oil free pump provides extended maintenance-free operation. Lightweight compressor weighs just 34 punds and has 2 couplers. Nailer features include adjustable depth-of-drive, jam release mechanism, non-marring nose tip, hardened driver blade, muffled, adjustable exhaust port. 1-year warranty
We are firm believers in getting more than what you pay for out of a tool, and Porter Cable's Three Nailer/Stapler and Compressor Combo Kit delivers a lot more bang for the buck. The 120-volt, 10-amp pump not only provides a continuous air supply for the nail and staple guns, but the portable 6-gallon air tank can supply up to 150 psi of air for other tools in your shop or garage. Not only do you get an oil-free, maintenance-free pump with 40 feet of quality 1/4–inch air hose and 2 couplers, but the three nailer stapler guns are like having an extra set of hands in the shop. No longer do you have to clamp two pieces of wood together so that you can hold a nail or brad in one hand and a hammer in the other. In the workshop you can use the brad nailer for fastening smaller wood projects or the ¼-inch stapler for installing items such as screen wire, low voltage wiring, upholstery, furniture coverings, or any project where a staple can be used in place of a screw.
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Former Names C3FeB6 A/Aw-J-ank/J (Changed: 15-DEC-04 ) Type Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Background Strain C3FeB6 Donor Strain JGBF F15 Generation N32 F2p
Generation Definitions
agouti with stiff feet
Related Genotype: A/A Ankank/Ankank
white-bellied agouti with stiff feet
Related Genotype: A/Aw-J Ankank/Ankank
agouti, unaffected
Related Genotype: A/A +/?
white-bellied agouti, unaffected
Related Genotype: A/Aw-J +/? or Aw-J/Aw-J +/?
The progressive ankylosis allele (ank) is a spontaneous recessive mutation that causes a severe phenotype of joint calcification and degeneration. Few homozygotes survive beyond 5 months of age, although the adults can breed. Generally no more than 2 litters are produced by homozygotes of either sex. At 4 or 5 weeks of age, homozygotes can be identified by their inability to grasp a wire cage lid with their front paws when suspended above it. The joints swell with a milky fluid, and undergo a process proceeding through mononuclear inflammatory infiltration, hydroxyapatite deposition and increased calcification, hyperplasia, and fibrous and bony ankylosis. (for details see Mahowald et al., 1989; Hakim et al., 1984; Sweet and Green, 1981.) The front feet are affected before the hind feet and the phenotype is more severe in the most distal joints of the limbs. Hyperplasia and degeneration of the joint tissues, and ankylosis occur progressively, decreasing mobility and resulting in a rigid, crouched posture in the adult. Their gate becomes slow, halting, and flatfooted. The morphological changes underlying the stiffening of the vertebral column and resulting thoracic kyphosis are detailed by Sampson, 1988a and 1988b, and Sampson et al., 1991.
There is an immune cell involvement in the joints secondary to the central defect. Treatment of ank/ank mice with hydrocortisone beginning at 5 weeks of age resulted in reduced synovial and subsynovial hyperplasia, reduced growth of cartilaginous and bony bridges, and increased accumulation of intra-articular apatite possibly due to the reduction in macrophage activity (Hakim et al., 1986.). Reconstitution of wild type mice with bone marrow or spleen cells from ank/ank mice does not transfer disease and reconstitution of ank/ank mice with wild type bone marrow or spleen cells does not prevent disease (Krug et al., 1997). Additionally, there is an immune cell defect. There is a reduction in the response of spleen cells to phytohaemagglutinin or concanavalin A although the response to LPS appears normal. Spleen cells or macrophages from ank/ank mice do not suppress normal spleen cell responses to phytohaemagglutinin and wild type spleen cells or macrophages do not restore phytohaemagglutinin responsiveness to spleen cells from ank/ank mice (Krug et al., 1989). Fibroblasts from ank/ank mice are Hyperproliferative in response to transforming growth factor beta 1 (Krug, 1998). No impact was found on the phenotype of ank/+ or ank/ank mice when transgenic HLA-B27 was co-expressed (Krug and Taurog, 2000).
In addition to progressive ankylosis and calcification of the peripheral joints and axial skeleton, homozygotes have a smaller overall body size, and some develop balanitis, priapism, and scaling skin lesions on the plantar surface of the paws. The hypermineralization phenotype is associated with abnormal inorganic pyrophophate levels and the downregulation of osteopontin (Harmey et al., 2004).
The progressive ankylosis mutation arose spontaneously in the strain JGBF/Le (Stock No. 000260), a balanced stock for jagged tail (jg) and buff (bf). An affected female displaying a flat-footed gait with rigid toes was the founder for the ank strain. This female's progeny were bred onto a C3FeB6 background via an outcross-intercross breeding scheme. Thus homozygotes were bred to C3FeB6F1 then their obligate heterozygous offspring were sibling mated to produce homozygous breeders for the next generation. The initial characterization was done on N5F1 mice. In June 1976 this strain was at N6, in early 1979 it was at N11, and in November 1983 it reached N24. Neither jg nor bf have been found in this strain since N2. C3FeB6-A/Aw-J-ank was frozen in 1987 by breeding N32 homozygotes to C3FeB6-A/Aw-J to get heterozygous N33 embryos.
|+/? sibling
|001203 C3FeB6F1/J A/Aw-J
|Considerations for Choosing Controls
Strains carrying A allele
002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J 000507 B6 x B6EiC3 a/A-Otcspf/J 000628 B6.CE-A Amy1b Amy2a5b/J 004200 B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 003301 B6C3FeF1 a/A-Eya1bor/J 006450 B6EiC3 a/A-Vss/GrsrJ 000557 B6EiC3-+ a/LnpUl A/J 000504 B6EiC3Sn a/A-Cacnb4lh/J 000553 B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 001923 B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J 000638 C3FeB6 A/Aw-J-Sptbn4qv-J/J 000283 LT.CAST-A/J 001759 STOCK A Tyrc Sha/J 001145 WSB/EiJView Strains carrying A (17 strains)Strains carrying Aw-J allele
000202 AEJ/Gn-bd/J 000199 AEJ/GnLeJ 000593 B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J 000502 B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J 000599 B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J 002016 B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ 000600 B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J 001809 B6.Cg-Aw-J EdaTa-6J +/+ ArTfm/J 000552 B6.Cg-Aw-J EdaTa-6J Sxr 001730 B6.Cg-Aw-J EdaTa-6J Sxrb Hya-/J 000841 B6.Cg-Aw-J EdaTa-By/J 100409 B6129PF1/J-Aw-J/Aw 004200 B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ 000505 B6C3 Aw-J/A-Bloc1s5mu/J 000501 B6CBACa Aw-J/A-Aifm1Hq/J 001046 B6CBACa Aw-J/A-Grid2Lc/J 000500 B6CBACa Aw-J/A-Gs/J 002703 B6CBACa Aw-J/A-Hydinhy3/J 000247 B6CBACa Aw-J/A-Kcnj6wv/J 000287 B6CBACa Aw-J/A-Plp1jp EdaTa/J 000515 B6CBACa Aw-J/A-SfnEr/J 000242 B6CBACa Aw-J/A-spc/J 000288 B6CBACa Aw-J/A-we a Mafbkr/J 001201 B6CBACaF1/J-Aw-J/A 000638 C3FeB6 A/Aw-J-Sptbn4qv-J/J 000338 C57BL/6J Aw-J-EdaTa-6J/J 000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J 000051 C57BL/6J-Aw-J/JView Strains carrying Aw-J (28 strains)Strains carrying other alleles of a
002655 Mus pahari/EiJ 000251 AEJ.Cg-ae +/a Gdf5bp-H/J 000202 AEJ/Gn-bd/J 000199 AEJ/GnLeJ 000433 B10.C-H3c H13? A/(28NX)SnJ 000427 B10.CE-H13b Aw/(30NX)SnJ 000423 B10.KR-H13? A/SnJ 000420 B10.LP-H13b Aw/Sn 000477 B10.PA-Bloc1s6pa H3e at/SnJ 000419 B10.UW-H3b we Pax1un at/SnJ 003879 B10;TFLe-a/a T Itpr3tf/+ Itpr3tf/J 001538 B6 x B6C3Sn a/A-T(1;9)27H/J 000916 B6 x B6C3Sn a/A-T(5;12)31H/J 000602 B6 x B6C3Sn a/A-T(8;16)17H/J 003759 B6 x B6EiC3Sn a/A-T(10;16)232Dn/J 002071 B6 x B6EiC3Sn a/A-T(11;17)202Dn/J 002113 B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J 002068 B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J 002069 B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J 001926 B6 x B6EiC3Sn a/A-T(15;16)198Dn/J 001832 B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J 003758 B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J 001833 B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J 001903 B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J 001535 B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J 001831 B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J 000618 B6 x FSB/GnEi a/a Ctslfs/J 000577 B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J 000601 B6 x STOCK a/a T(7;18)50H/J 000592 B6 x STOCK T(2;4)13H a/J 000769 B6.C/(HZ18)By-at-44J/J 000203 B6.C3-Aiy/a/J 000017 B6.C3-Avy/J 001572 B6.C3-am-J/J 000021 B6.Cg-Ay/J 014608 B6;129S1-a Kitlsl-24J/GrsrJ 000231 B6;C3Fe a/a-Csf1op/J 000785 B6;D2-a Ces1ce/EiJ 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 001750 B6C3Fe a/a-Eif3cXs-J/J 000245 B6C3Fe a/a-Hgstn/J 002807 B6C3Fe a/a-Meox2fla/J 000506 B6C3Fe a/a-Qkqk-v/J 000224 B6C3Fe a/a-Scyl1mdf/J 003020 B6C3Fe a/a-Zdhhc21dep/J 001037 B6C3Fe a/a-Agtpbp1pcd/J 000221 B6C3Fe a/a-Alx4lst-J/J 002062 B6C3Fe a/a-Atp7aMo-8J/J 001756 B6C3Fe a/a-Cacng2stg/J 001815 B6C3Fe a/a-Col1a2oim/J 000209 B6C3Fe a/a-Dh/J 000211 B6C3Fe a/a-Dstdt-J/J 000210 B6C3Fe a/a-Edardl-J/J 000207 B6C3Fe a/a-Edaraddcr/J 000182 B6C3Fe a/a-Eef1a2wst/J 001278 B6C3Fe a/a-Glra1spd/J 000241 B6C3Fe a/a-Glrbspa/J 002875 B6C3Fe a/a-Hoxd13spdh/J 000304 B6C3Fe a/a-Krt71Ca Scn8amed-J/J 000226 B6C3Fe a/a-Largemyd/J 000636 B6C3Fe a/a-Lmx1adr-J/J 001280 B6C3Fe a/a-Lse/J 001573 B6C3Fe a/a-MitfMi/J 001035 B6C3Fe a/a-Napahyh/J 000181 B6C3Fe a/a-Otogtwt/J 000278 B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J 000205 B6C3Fe a/a-Papss2bm/J 002078 B6C3Fe a/a-Pcdh15av-2J/J 000246 B6C3Fe a/a-Pitpnavb/J 001430 B6C3Fe a/a-Ptch1mes/J 000235 B6C3Fe a/a-Relnrl/J 000237 B6C3Fe a/a-Rorasg/J 000290 B6C3Fe a/a-Sox10Dom/J 000230 B6C3Fe a/a-Tcirg1oc/J 003612 B6C3Fe a/a-Trak1hyrt/J 001512 B6C3Fe a/a-Ttnmdm/J 001607 B6C3Fe a/a-Unc5crcm/J 000005 B6C3Fe a/a-Wc/J 000243 B6C3Fe a/a-Wnt1sw/J 000248 B6C3Fe a/a-Xpl/J 000624 B6C3Fe a/a-anx/J 008044 B6C3Fe a/a-bpck/J 002018 B6C3Fe a/a-din/J 002339 B6C3Fe a/a-nma/J 000240 B6C3Fe a/a-soc/J 000063 B6C3Fe a/a-sy/J 001055 B6C3Fe a/a-tip/J 000065 B6C3Fe a/a-we Pax1un at/J 000296 B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J 000019 B6C3Fe-a/a-Itpr1opt/J 001022 B6C3FeF1/J a/a 006450 B6EiC3 a/A-Vss/GrsrJ 000971 B6EiC3 a/A-Och/J 000551 B6EiC3 a/A-Tbx15de-H/J 000557 B6EiC3-+ a/LnpUl A/J 000503 B6EiC3Sn a/A-Gy/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 000391 B6EiC3Sn a/A-Pax6Sey-Dey/J 001923 B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J 001875 B6EiC3SnF1/J 000225 C3FeLe.B6 a/a-Ptpn6me/J 000198 C3FeLe.B6-a/J 000291 C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J 001272 C3H/HeSnJ-Ahvy/J 000099 C3HeB/FeJ-Avy/J 001886 C3HeB/FeJLe a/a-gnd/J 000584 C57BL/6J-+ T(1;2)5Ca/a +/J 000258 C57BL/6J-Ai/a/J 000774 C57BL/6J-Asy/a/J 000055 C57BL/6J-at-33J/J 000070 C57BL/6J-atd/J 000284 CWD/LeJ 000670 DBA/1J 000671 DBA/2J 001057 HPT/LeJ 000260 JGBF/LeJ 002468 KK.Cg-Ay/J 000262 LS/LeJ 000265 MY/HuLeJ 000308 SSL/LeJ 000994 STOCK a Myo5ad Mregdsu/J 000064 STOCK a Tyrp1b Pmelsi/J 002238 STOCK a Tyrp1b shmy/J 001433 STOCK a skt/J 000579 STOCK a tp/J 000319 STOCK a us/J 002648 STOCK a/a Cln6nclf/J 000302 STOCK a/a MitfMi-wh +/+ Itpr1opt/J 000286 STOCK a/a Myo5ad fd/+ +/J 000281 STOCK a/a Tmem79ma Flgft/J 000206 STOCK a/a Tyrc-h/J 001432 STOCK a/a Tyrp1b Ndc1sks/Tyrp1b +/J 000312 STOCK stb + a/+ Fignfi a/J 000596 STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J 000970 STOCK T(2;16)28H A/T(2;16)28H a/J 000590 STOCK T(2;4)1Sn a/J 000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J 000623 TR/DiEiJView Strains carrying other alleles of a (139 strains)
View Related Disease (OMIM) TermsRelated Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.Chondrocalcinosis 2; CCAL2 (ANKH)
Craniometaphyseal Dysplasia, Autosomal Dominant; CMDD (ANKH)
View Mammalian Phenotype TermsMammalian Phenotype Terms provided by MGIassigned by genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.
Ankank/Ankankinvolves: C3HeB/FeJ * C57BL/6J * JGBF/LeJ
- mortality/aging
- premature death
- few mutants survive beyond 5 months of age (MGI Ref ID J:6580)
- growth/size/body region phenotype
- abnormal tooth hard tissue morphology
- abnormal cementum morphology
- at 12 weeks, enlargement of the cementum (MGI Ref ID J:122727)
- decreased body weight
- lower body weight, first noticeable between 10 and 20 days of age (MGI Ref ID J:6580)
- reproductive system phenotype
- reduced female fertility
- do not produce more than two litters (MGI Ref ID J:6580)
- reduced male fertility
- do not produce more than two litters (MGI Ref ID J:6580)
- skeleton phenotype
- abnormal joint mobility
- joint mobility is decreased at 6 weeks and is more severe at 12 weeks similar to in Anktm1.1Kng homozygotes (MGI Ref ID J:122727)
- reduction in joint mobility in the forelimb joints are more severe than in the hindlimbs and distal joint in the hindlimbs are more severely affected than proximal joints (MGI Ref ID J:122727)
- progressive loss of mobility of the joints occurs with age; stiffening of the joints is first apparent at 4-5 weeks of age in the forefeet and eventually involves all the joints of the limbs and vertebral column (MGI Ref ID J:6580)
- when lifted by the tail from a wire grid, 4.5-5 week old mutants are unable to cling to the grid as the toes are very rigid (MGI Ref ID J:6580)
- wean age homozygotes are unable to grasp a wire cage tope due to stiffness in the digits (MGI Ref ID J:63420)
- stiffness of joints observed at 4-5 weeks of age (MGI Ref ID J:168526)
- abnormal skeleton morphology
- progressive ankylosis (MGI Ref ID J:6580)
- abnormal cartilage morphology
- abnormal femur morphology
- metaphyseal trabeculae reduced in both thickness and number (MGI Ref ID J:168526)
- abnormal joint morphology
- mutants develop a noninflammatory degenerative joint disease, with stiffness of joints starting in forefeet and toes, quickly spreading to other joints (MGI Ref ID J:6580)
- bone volume in joints is significantly increased and increases in severity with time (MGI Ref ID J:122727)
- mutants show increased numbers of osteoblast-like cells in the synovial membrane of joints and excessive amount of fibrous tissue, cartilage, and bone in joints at later stages, with many areas of cystic necrosis (MGI Ref ID J:6580)
- synovial lining in most places, except over articular cartilage or ligament, has a thickened surface layer (MGI Ref ID J:6580)
- joint space narrowing, accumulation of debris in the joint space, and ectopic calcification in and around the affected joints (MGI Ref ID J:63420)
- necrosis in the fibrous tissue of the joints, including the ligaments and cartilage (MGI Ref ID J:6580)
- abnormal joint capsule morphology
- calcified joint
- abnormal and increased calcification within some of the joints (knee, elbow, vertebral column) and joint cavities, resulting in calcified masses at various places near joints (MGI Ref ID J:6580)
- ectopic calcification in and around the affected joints (MGI Ref ID J:63420)
- excessive bony deposits in joints (MGI Ref ID J:168526)
- fused joints
- progressive akylosis, such that by 17 weeks of age, the joints of the foot, including the wrist, and of the ribs with adjacent sternebrae are completely ankylosed (MGI Ref ID J:6580)
- fore and hind feet at 31 weeks of age have toe bones that show bony and cartilaginous fusions across the joints, usually including the sesamoid bones (MGI Ref ID J:6580)
- abnormal ligament morphology
- abnormal sesamoid bone of gastrocnemius morphology
- some of the sesamoid bones are enlarged and appear to be fused with the nearest long bone (MGI Ref ID J:6580)
- abnormal tendon morphology
- degeneration in many, although not all, tendons associated with affected joints (MGI Ref ID J:6580)
- kyphosis
- adults exhibit thoracic kyphosis and prominent haunches (MGI Ref ID J:6580)
- arthritis
- histology of the digit joints shows narrowing of the joint spaces, erosion of cartilage, accumulation of debris, and ectopic calcification (MGI Ref ID J:63420)
- muscle phenotype
- abnormal tendon morphology
- degeneration in many, although not all, tendons associated with affected joints (MGI Ref ID J:6580)
- craniofacial phenotype
- abnormal tooth hard tissue morphology
- abnormal cementum morphology
- at 12 weeks, enlargement of the cementum (MGI Ref ID J:122727)
- behavior/neurological phenotype
- abnormal gait
- slow halting gait, with all feet flat against the surface (MGI Ref ID J:6580)
- abnormal posture
- adults exhibit a rigid posture (MGI Ref ID J:6580)
- decreased grip strength
- unable to grab cage bars at 4-5 weeks of age (MGI Ref ID J:168526)
- limbs/digits/tail phenotype
- abnormal limb morphology
- in the limbs, abnormalities are more severe in the distal than proximal joints and in the forelimbs than in the hindlimbs (MGI Ref ID J:6580)
- abnormal digit morphology
- toes of the forefeet are stiff and flattened at 33 and 35 days of age, while these abnormalities occur later in the hindfeet (11-17 weeks of age) (MGI Ref ID J:6580)
- abnormal femur morphology
- metaphyseal trabeculae reduced in both thickness and number (MGI Ref ID J:168526)
- abnormal sesamoid bone of gastrocnemius morphology
- some of the sesamoid bones are enlarged and appear to be fused with the nearest long bone (MGI Ref ID J:6580)
- homeostasis/metabolism phenotype
- abnormal ion homeostasis
- primary skin fibroblast cultures show an increase in intracellular and a decrease in extracellular pyrophosphate indicative of defective phosphate homeostatis, and this defect is corrected by transfection with wildtype Ank (MGI Ref ID J:63420)
- immune system phenotype
- arthritis
- histology of the digit joints shows narrowing of the joint spaces, erosion of cartilage, accumulation of debris, and ectopic calcification (MGI Ref ID J:63420)
Ankank/Ankankinvolves: BALB/c * C3H * C57BL/6 * JGBF/Le
- skeleton phenotype
- abnormal osteoblast physiology
- cardiovascular system phenotype
- calcified aorta
- aortic media exhibit calcification and chondrogenic differentiation unlike wild-type aortas (MGI Ref ID J:110028)
Ankank/AnkankBackground Not Specified
- skeleton phenotype
- abnormal chondrocyte morphology
- 6-8 week old affected mice have chondrocytes with numerous large vacuoles and abnormal condensations of glycogen (MGI Ref ID J:751)
- abnormal intervertebral disk morphology
- EM analysis shows accumulation of electron-dense crystals aligned along collagen fibers; mitochondria of some cells have a high affinity for calcium phosphate crystals (MGI Ref ID J:751)
- in some disk regions cartilage is so heavily mineralized that mineral deposists extend beyond the extracellular matrix over cell cytoplasm (MGI Ref ID J:751)
- ossification of intervertebral disk space is common (MGI Ref ID J:751)
- calcified intervertebral disk
- crystals are in the form of calcium hydroxyapatite (MGI Ref ID J:751)View Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Ankank related
Dermatology Research
Skin and Hair Texture Defects
Developmental Biology Research
Growth Defects
Growth Defects (homozygous)
Skeletal Defects
Immunology, Inflammation and Autoimmunity Research
Immunodeficiency Associated with Other Defects
|Allele Symbol
|Allele Name
|wild-type agouti
|Allele Type
|Common Name(s)
|dark-bellied agouti;
|Strain of Origin
|Gene Symbol and Name
|a, nonagouti
|Gene Common Name(s)
|AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
|General Note
|The A allele is usually regarded as a wild-type allele. For example,the C3H and CBA mouse sublines are homozygous for agouti. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back.
|Molecular Note
|This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene. [MGI Ref ID J:3523]
|Allele Symbol
|Allele Name
|white bellied agouti Jackson
|Allele Type
|Common Name(s)
|Strain of Origin
|Gene Symbol and Name
|a, nonagouti
|Gene Common Name(s)
|AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
|Allele Symbol
|Allele Name
|progressive ankylosis
|Allele Type
|Common Name(s)
|Strain of Origin
|Gene Symbol and Name
|Ank, progressive ankylosis
|Gene Common Name(s)
|CCAL2; CMDJ; CPPDD; D15Ertd221e; DNA segment, Chr 15, ERATO Doi 221, expressed; HANK; MANK; mKIAA1581;
|Molecular Note
|A single nucleotide G to T substitution is predicted to result in a substitution at codon 440 from Glu to a stop codon in the encoded protein. [MGI Ref ID J:63420]
Genotyping ProtocolsAw-J, Separated PCR
Helpful LinksGenotyping resources and troubleshooting
Hakim FT; Brown KS; Oppenheim JJ. 1986. Hereditary joint disorder in progressive ankylosis (ank/ank) mice. II. Effect of high-dose hydrocortisone treatment on inflammation and intraarticular calcium hydroxyapatite deposits. Arthritis Rheum 29(1):114-23. [PubMed: 3004514] [MGI Ref ID J:109949]
Hakim FT; Cranley R; Brown KS; Eanes ED; Harne L; Oppenheim JJ. 1984. Hereditary joint disorder in progressive ankylosis (ank/ank) mice. I. Association of calcium hydroxyapatite deposition with inflammatory arthropathy. Arthritis Rheum 27(12):1411-20. [PubMed: 6095872] [MGI Ref ID J:7672]
Ho AM; Johnson MD; Kingsley DM. 2000. Role of the mouse ank gene in control of tissue calcification and arthritis [see comments] Science 289(5477):265-70. [PubMed: 10894769] [MGI Ref ID J:63420]
Krug HE. 1998. Fibroblasts from mice with progessive ankylosis proliferate excessively in response to transforming growth factor-beta 1. J Investig Med 46(4):134-9. [PubMed: 9635372] [MGI Ref ID J:109902]
Krug HE; Mahowald ML; Clark C. 1989. Progressive ankylosis (ank/ank) in mice: an animal model of spondyloarthropathy. III. Proliferative spleen cell response to T cell mitogens. Clin Exp Immunol 78(1):97-101. [PubMed: 2805429] [MGI Ref ID J:109935]
Krug HE; Taurog JD. 2000. HLA-B27 has no effect on the phenotypic expression of progressive ankylosis in ank/ank mice J Rheumatol 27(5):1257-9. [PubMed: 10813297] [MGI Ref ID J:62431]
Krug HE; Wietgrefe MM; Ytterberg SR; Taurog JD; Mahowald ML. 1997. Murine progressive ankylosis is not immunologically mediated. J Rheumatol 24(1):115-22. [PubMed: 9002021] [MGI Ref ID J:109905]
Mahowald ML; Krug H; Halverson P. 1989. Progressive ankylosis (ank/ank) in mice: an animal model of spondyloarthropathy. II. Light and electron microscopic findings. J Rheumatol 16(1):60-6. [PubMed: 2541245] [MGI Ref ID J:23576]
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A relatedAw-J related
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Animal Health ReportsProduction of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
|Pricing for USA, Canada and Mexico shipping destinations
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3435.00
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
|Pricing for International shipping destinations
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $4465.50
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
|+/? sibling
|001203 C3FeB6F1/J A/Aw-J
|Considerations for Choosing Controls
|Control Pricing Information for Genetically Engineered Mutant Strains.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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Coco and Ice-T celebrate New Year's at Nuela in New York City. (December 31, 2010)
No! Not too close. Close is bad.
agreed… she is more a hot from far away gal
she is overdue for a replacement of those implants. yuk.
WEIRD you can see where the real boob ends and fake boob begins..
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- Willamette
- Athletics
- News Archive
- 2004
- September
- Bearcats Lose to Western Baptist 4-1
Men's Soccer | Saturday, September 11, 2004
Bearcats Lose to Western Baptist 4-1
SALEM, Ore. — Western Baptist College got a pair of goals by freshman Josh Crain as the Warriors defeated the Willamette University men's soccer team 4-1 Saturday afternoon.
The Warriors (4-1) got on the board just 46 seconds into the match. Micah Pruss slipped a pass in front of the net and Seth Burke scored on a shot off the left post.
Western Baptist held a 2-0 margin at halftime after a Caleb Louvier score. The Warriors' Crain had both Western goals in the second half.
The Bearcats (0-2-2) avoided a shutout in the 61st minute when Zach Reeves' 12-yard shot deflected off a defender past WB keeper Brett Bentley.
Willamette starts its Northwest Conference slate on Wednesday, entertaining Linfield College at 3 p.m. at Sparks Field. The women play Linfield at 5 p.m.


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Saturday, March 25, 2006
© Copyright 2015 Gwinnett Daily Post
Lord, deliver us from mixing politics and religion. I can't help but notice that there seems to be a rash of it these days. The Georgia General Assembly has passed or is about to pass -- depending on what happened between the time this was written and the time it was published -- a bill that would allow the teaching of the Bible in Georgia public schools -- at the state's expense. The Bible can already be taught, in certain situations, if the local school system picks up the bill.Who could be against teaching the Bible? After all, its teachings are the cornerstone of our nation. We are a part of a Judeo-Christian society, and our most cherished government documents, not to mention our art and literature, are chock full of Biblical references. We don't want students graduating from Georgia high schools misinterpreting Michelangelo's depiction of Creation on the ceiling of the Sistine Chapel -- and how will they understand all the David and Goliath analogies during the NCAA basketball tournament if they don't know the story of David and Goliath? Speaking of sports analogies, they should certainly know that "Duke can't carry LSU's sneakers" is a direct reference to John the Baptist's comments when Jesus came to be baptized at the River Jordan. And don't even try to appreciate Shakespeare if you don't know the Bible. So there you go. Let's pass a bill allowing schools to teach the Bible -- as an elective -- so students will have a better grasp of history, literature and art. Hmmmm. I'm all for studying the Bible, understand. In fact, I bring up references to the Bible -- as well as other religious books and doctrines -- in my U.S. history class all the time. You can't understand American history without understanding the role religion has played since our inception. On Sundays, I teach an adult Sunday school class and we study the Bible on a verse-by-verse basis. But when you start teaching the Bible in a public school, you run the risk of opening a large, economy size can of worms. Questions, questions, questions. What if some religious zealot is assigned to teach the course and tries to convince a Muslim student to convert to Christianity? What if the teacher teaches the Bible as an allegory and I want my child to believe that it is the divine Word of God, inspired by the Holy Spirit? What if they use the New Revised Standard edition and we are strictly King James at our house? What if they hire an atheist to teach the course and he or she contradicts or even ridicules my child's beliefs? What if, what if, what if? Not to worry, y'all. I am 100 percent certain that our politicians would not implement any type of plan or program that has not been thoroughly checked out. I am sure that all eventualities will have been taken into consideration before the first "Thou shalt not" has been studied in any way, shape or form. I am certain that only qualified instructors will be allowed to teach the class, and that no personal bias will ever, ever, ever work its way into the lesson. And I am sure that Santa will bring me a new Cadillac this Christmas and that we will leave no child behind. We might hold a few really bright ones back, but we won't leave anybody behind. And speaking of politics and religion -- which, along with sex and college football are things you should never, ever, ever discuss in a social setting -- Hillary Clinton decided to demonstrate her knowledge of the Bible in front of the entire U.S. Senate this week. Hillary, you see, has decided that she does not want Congress to pass legislation to restrict illegal immigration. What she really said was that Congress was attempting to turn "undocumented aliens" into criminals. Now I truly believe that America is the land of opportunity -- "Give me your tired, your, poor, your huddled masses" and all that. But if the law says that you must be documented to come into the country, and you aren't documented, then you are here illegally and if you are doing something illegal, you are already a criminal by definition. But Hillary also said that, based on the law in question, the Congress of the United States would have made criminals of Jesus and the Good Samaritan, too. I know that Hillary Clinton would never make Biblical references just to win favor with voters in the Bible belt, and I am certain that she is well versed in Scripture, but I don't think Jesus ever traveled far enough from home or stayed long enough in one place to be considered an illegal anything -- and I am sure he never had a counterfeit green card or avoided rendering unto Caesar by getting paid under the table in cash money. And as for the Good Samaritan, if Hillary were to read the story again, she would learn that he was just passing through. I don't think anyone is opposed to the folks who are just passing through, any more than they are to the ones who are here legally. But it's an election year, y'all. Stay tuned. things are going to get very, very interesting. Darrell Huckaby is a Newton County native and the author of six books. He lives in Rockdale County, where he teaches high school history. Visit his Web site at www.darrellhuckaby.net.
More like this story
- Letters to the Editor ( December 15, 2005 )
- Religion too often invoked only out of convenience ( October 13, 2005 )
- Clinton causes own problems ( November 2, 2007 )
- National press allows double standard on racial comments by Nagin,Clinton ( January 21, 2006 )
- Please don't rain on our prayer service ( November 16, 2007 )


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