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Bruce J. Winick
Professor of Law
Professor of Psychiatry and Behavioral Sciences,
University of Miami Miller School of Medicine
J.D. 1968, New York University School of Law
Publications | SSRN | Website
Bruce J. Winick was a Professor of Law and Professor of Psychiatry and Behavioral Sciences at the University of Miami Miller School of Medicine. The co-founder of the school of social enquiry known as therapeutic jurisprudence, Winick was Director of the University of Miami School of Law Therapeutic Jurisprudence Center. He was the first the recipient of the Laurie Silvers & Mitchell Rubenstein Distinguished Professorship during the 2009-2010 academic year.
Winick authored, co-authored, and co-edited numerous books, including Civil Commitment: A Therapeutic Jurisprudence Model (Carolina Academic Press 2005), Judging In A Therapeutic Key: Therapeutic Jurisprudence And The Courts (Carolina Academic Press 2003), Protecting Society From Sexually Dangerous Offenders: Law, Justice And Therapy (American Psychological Association Books 2003), Practicing Therapeutic Jurisprudence: Law As A Helping Profession (Carolina Academic Press 2000), The Essentials Of Florida Mental Health Law (W. W. Norton 2000), The Right To Refuse Mental Health Treatment (American Psychological Association Books 1997), Therapeutic Jurisprudence Applied: Essays On Mental Health Law (Carolina Academic Press 1997), Law In A Therapeutic Key: Developments In Therapeutic Jurisprudence (Carolina Academic Press 1996), and Essays In Therapeutic Jurisprudence (Carolina Academic Press 1991). He also authored over 100 articles in law reviews and interdisciplinary journals.
Winick was Chair of the American Association of Law Schools' section on Balance in Legal Education. He was co-editor of the American Psychological Association Books book series, Law and Public Policy: Psychology and the Social Sciences. Winick was also legal advisor and member of the board of editors of Psychology, Public Policy & Law, served on the editorial board of Law & Human Behavior, and was a reviewer for numerous interdisciplinary law journals. He served as legal consultant to the American Psychiatric Association Task Force on Consent to Voluntary Hospitalization, and has chaired the Association of American Law Schools Section on Law and Medicine.
Winick received numerous awards. In 2009, he received the Philippe Pinel Award of the International Academy of Law and Mental Health, the Academy's highest honor. In 2007, he was named Honorary Distinguished Member of the American Psychology-Law Society. He also received the University of Miami Provost's Award for Scholarly Excellence, the Thurgood Marshall Award of the Association of the Bar of the City of New York, and the Human Rights Award of the American Immigration Lawyers Association.
Prior to joining the faculty of the University of Miami, Professor Winick served as New York City's Director of Court Mental Health Services and as General Counsel of the New York City Department of Mental Health and Mental Retardation Services. He received his law degree from the New York University School of Law.
Professor Winick taught Constitutional Law II, Advanced Criminal Procedure, New Directions in Lawyering: Interviewing, Counseling, and Attorney/Client Relational Skills, Psychology and Law seminar, and Therapeutic Jurisprudence seminar.
University of Miami: President Donna Shalala's Statement
The Miami Hurricane: UM Professor Loses Battle to Cancer
Daily Business Review: Pioneering Miami Law Professor Dies at 65
PrawfsBlawg: Professor Jonathan Simon from Berkeley Law remembers Professor Winick
Brian Leiter's Law School Reports
Cutting Edge Law: Publisher of Cutting Edge Law remembers Professor Bruce Winick


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Yoga, at its very essence is about the union of things - body and mind, breath and movement. It combines a dynamic form of physical exercise with a philosophy that you can apply to your everyday life. You master the art of directing your breathing to various organs of your anatomy, thereby creating a process of healing, while at the same time, toning the body.
This is accomplished through special yoga techniques; Sanskrit Chantings or hymns focus on sound and thought; Mind Imagery is the the mind's visualisation used to learn to slow down, speed up or stop; Panic Re-energisation, or the Vital Energy, is comtemplation on breath; Mind Resonance or mantras balances the mind's alertness and activity levels.
At The BodyHoliday, beginners can practice Restorative Yoga and for those who want to acquire more advanced skills, Yoga Flow.
People of all ages can reap its benefits.
Daily yoga classes are included in the price of your holiday.
Dr. Abhishek Jain
Abhishek is our Indian yoga teacher and has practiced and taught the traditional Hatha Yoga method for over 12 years. He is trained and certified by Rajiv Gandhi University of Health Sciences, Bangalore, India. His classes embody the sequential practice of sun salutation, asanas, pranayama, relaxation and meditation. The aim of his teachings is to help you achieve higher levels of self-awareness and deeper relaxation.
One-on-one yoga programmes are available. Please download the wellness centre brochure for more details.
• Rooms
• Yoga
• The Beach
• The Piano Bar
• Laughter and Joy
• Extra Stuff

subset: commoncrawl


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Coastal Georgia CEASR Releases 3rd Report for 2012
Brunswick, GA – Dr. Don Mathews, Professor of Economics and Director of the Coastal Georgia Center for Economic Analysis and Student Research, School of Business and Public Affairs, says that regional transportation and warehousing are experiencing growth in line with the quickened pace of economic recovery. The release of the 3rd issue of the Southeast Georgia Coastal Monitor reports the six-county region is benefiting from the boom in international trade.
"The brightest light in the recovery from the 2007-09 recession has been international trade. U.S. exports now total $1.8 trillion, 19 percent greater than their 2009 level and 8 percent greater than their pre-recession peak. U.S. imports now total $2.2 trillion, 18 percent more than their 2009 level and almost even with their pre-recession peak," Dr. Mathews writes.
"Southeast Georgia is an integral part of the growth of transportation and the boom in international trade. The Port of Brunswick—the 5th largest auto port in the U.S., the 3rd largest in the U.S. for auto imports, and the 2nd largest grain facility on the East coast—is shattering its previous records for vessel calls and cargo handled. Auto processing and distribution are booming, and the agri-bulk facility is busier than ever."
Produced for the Southeast Georgia (SEGA) Joint Development Authority, the research by the Center reported in the Southeast Georgia Coastal Monitor helps to promote viability of economic development for the six-county region of Brantley, Camden, Charlton, Glynn, McIntosh, and Wayne.
The SEGA Joint Development Authority commissions the quarterly economic monitoring reports, which are available in a pdf format online. To review the current issue: http://www.southwindstechnologies.com/SoutheastGeorgiaSitesFlipBook/SEGA.html
|Release Date: 12/7/2012
Source: College of Coastal Georgia
|Media Contact:
John Cornell


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Nov 18 2013
Sewing a Bright Future
A fast, rhythmic sound comes from one small classroom. Thump, thump, thump, thump, thump. It's a tailoring workshop where children between 11 and 16 years of age operate around 25 high-speed sewing and stitching machines.
Jul 11 2013
It's Time for a Photo Scavenger Hunt
We're holding a photo scavenger hunt for the rest of July, complete with prizes. So, get your camera (or phone) ready.
Feb 4 2009
Sewing Mamas Work for a Better Future
For three months the women met, sitting at their sewing machines, not only learning a skill to help them support their families, but also gaining new hope and faith in God.
This exceptional group of women at Centro de Desarrollo Gracia y Poder student center in Honduras benefited through a workshop carried out through our Complementary Interventions programs.


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Great Coates residents carry on fight to stop £300,000 loan for village hall
Posted: May 19, 2012|
CONTROVERSIAL plans to take out a £300,000 loan to build a new village hall in Great Coates dominated a second public meeting this week.
Residents attended the annual parish meeting on Thursday to share their views on the council's "undemocratic" decision to take out a loan for a new hall – despite two polls revealing they are vehemently against it.
The topic had also been explored in detail at Great Coates Parish Council's monthly meeting at Great Coates Nursery on Tuesday evening, as reported.
Reading from the council's annual report at the latest meeting, vice-chairman Bob Emmerson said: "The results of the polls were advisory only and not lawfully binding.
Related content
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Confidence vote in Great Coates parish council amid row over village hall
Great Coates Parish Council survey into village reading rooms 'step in right direction'
Parish council branded 'a North Korean dictatorship' by Great Coates resident at meeting
Great Coates asked to submit views about their parish council
Great Coates village hall work starts on Monday – despite protests
"The village council noted the results but did not wish to rescind its decision to provide a new-build village hall and so proceeded with the project."
However, Mr Emmerson said he will pay a visit to the dilapidated Reading Rooms – which residents believe could be converted into a village hall at a lower cost than building a new one from scratch.
He said: "I think converting the Reading Rooms is a commendable aim and I am looking forward to seeing inside."
Parish clerk Kathy Nunn explained to the meeting how the council had attempted to buy the Reading Rooms from owners Sutton Estates in the past but had failed.
She said Sutton Estates then applied for planning permission to convert the Reading Rooms into a dwelling but was told it could only do so if an alternative site for a community facility was found.
This was when the site at Pear Tree Paddock was gifted to the village for the creation of a new village hall for a "peppercorn" annual rent.
Neil Wherrett, of Great Coates Residents' Association (Grass), said the Reading Rooms conversion could become a community project, with residents contributing their skills to get the work done.
He added: "If the Reading Rooms was a viable option it would bring the village back together.
"There are people who are skilled who could help transform the Reading Rooms. If we could bring the £300,000 loan down to £150,000 then I would say we should go ahead.
"But if the council goes ahead with the £300,000 loan then it is the people who steamrolled it through without listening to residents who will be held responsible."
Ex-councillor Danny Prest said residents are so against the £300,000 loan because of the increased precept they will have to pay for the next 50 years.
He said: "It is unacceptable to expect people to pay for a loan like this in what is a time of hardship.
"Many people are on a limited income, such as a pension, and I don't think they could just take the extra payment in their stride."
One resident, who did not wish to be named, added: "This issue has shattered the village and I think we all need to take a step back and forget about it for the time being while we work out what we all want.
"The Reading Rooms were always very dark because of the wood panelling but they could easily be lightened up.
"It was larger than people thought inside and could accommodate 120 people seated so it would be big enough."


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For nearly 30 years Breese
Landscaping has provided residential landscape design and
installation including water features, plants, hardscapes, irrigation
& lighting systems and more to bring you backyard dreams to life. All jobs,
large or small, are uniquely designed to create a custom landscape to fit your budget.
We look forward to the opportunity to provide you with exceptionally designed landscaping, quality installation and renowned customer service. At Breese Landscaping we pride ourselves on originality and custom designs. If you can imagine it we can build it!
We have been serving Phoenix and the Valley of the Sun for nearly 30 years. We are licensed, bonded, and insured. This is One Stop Shopping for all your landscape, hardscape, and construction needs.
The most common phrases uttered by our customers - "This exceeds my expectations!" I never dreamed my yard could look like this!"
You will be amazed at the dramatic difference a custom landscape can achieve!
We can transform your yard into your own private resort. We go for the "WOW"!
We now invite you to browse through our photo gallery. We are proud of our work and it shows!
To view our amazing work Click Here
Thank you for your time. We hope you are impressed by what you see and will contact us today.


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Lovell Rugby can today now unveil the new Adidas Predator X Colour Update in the stunning Silver/Blue. The colourway has been seen by alot of Adidas's top sponsored Rugby players in matches over the last two weeks. So far Players such as Dan Carter, Jimmy Cowan, Luke Mcalister, Joe Rokocoko, Delon Armitage, Matt Banahan, Matt Giteau, Lee Byrne, Pierre Spies and Bryan Habbana,
The Adidas Predator X is the Tenth Generation of Predator shoes. The boot is the same as the current Predator X Rugby boot but now in a more bold colourway, which alot of Adidas sponsored players have wanted to wear.
Adidas plan to roll the boot into full force next season with even more players wearing this great colourway and the current classic black and blue version which will still be worn by a whole host of stars including Jonny Wilkinson, Ronan O'gara, Stephen Jones, Leigh Halfpenny, Jonathan Sexton and many more.
The upper features a Newly developed Taurus full-grain calf leather to provide a even more comfortable boot, a natural look and great tear and abrasion resistance so that these boots last even longer. The Predator technology has also been perfected so that this soft compound provides unparalleled swerve, control, and accuracy on all of your touches. The EVA insole is anatomically moulded so that your foot has the most comfort possible. In addition The Predator X features the TRAXION SG Hybrid Stud sole system, this helps offer great traxion and grip while keeping the weight of the boot down.
The boot will be available to order from the 28th June 2010.
As ever we love to hear your feedback- what do you think?


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- Filed Under
Dog of the Week
Abigail is a female border collie mix who is about 3 months old. A CARA staff member found her on a cold morning, dodging traffic on a busy highway. She loves everyone and would give just about anything to have a loving family to call her own. She would be the perfect girl for a family with children.
Cat of the Week
This beautiful girl is Sarah, and she is about a year old. Sarah is the last of her family remaining at the shelter. She would fit right into a home that already has cats, as she does great with all of the cats in the shelter.


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Format: Captain's Choice, Shotgun Start at 1:00Grounds open at 11:30 for registration and putting practiceTournament Fee Includes:• 18 holes with cart• Box Lunch at 12:00: Sponsored by Friendship Retirement Community• Beverages available on course: Sponsored by P.A. Short Distributing• Tournament Gift Bag: Sponsored by HVCC, Collegiate Pacific, Rockydale Quarries Corp., Budweiser• Cocktail Buffet Dinner - Cash bar.o Non-player tickets $20.00Additional Items Available:o Long Putt Contest – Win $1,000.00. First round qualifies players, Finals at 6:30 - $5.00 per putt (players may buy as many tries as they wish)• Entry into 3 on-course games: $5.00o Hole in One – WIN A Toyota Corolla Sponsored by Haley Toyotao Longest Drive – win a round of golf at a local golf courseo Closest to the Pin – win a round of golf at a local golf course• Mulligan Package - $20 each:o 2 Mullliganso Entry into all 3 on-course competitions ($5.00 value)o 1 Entry into Long Putt Contest ($5.00 value)
Hidden Valley Country Club, 2500 Romar Ave., Salem, VA 24153
Pre-registration Deadline is Tax Day April 15th. After April15th, please contact the Zoo at (540) 343-3241. ext. 25 for availabilityEntry Fee: $100.00 per golfer, or $360.00 if all 4 team members pre-register and pay prior to April 15th.
Box lunch served in Grill and patio starting at noon. After the round, there will be a cocktail buffet dinner in the HVCC clubhouse and patio. Non-player tickets are available for $20 for the dinner. These may be purchased the day of the tournament at the registration table.
Adult Beverages will be available on the course, sponsored by PA Short Distributing. There will be a cash bar during the cocktail party.
Tournament Fee Includes:18 holes of golf with cartTournament Gift Bag (sponsored by Collegiate Pacific, Rockydale Quarries Corp, Alien Sportswear, PA Short Distributing)Cocktail Buffet Dinner at 6:30Mulligan Package available for $20: 2 pre-paid Mulligans Entry into all 3 on-course contests 1 Entry into $1,000 Long-Putt ContestPlease wear proper golf attire. No jeans are allowed on the course.Rain cancellation will be determined by the HVCC golf pro. Announcement of cancellation will be posted on the Home Page of the Mill Mountain Zoo website and the HVCC website.In the event of a weather cancellation of the golf tournament, the dinner will be held in the ballroom of HVCC at 6:00 on the day of the tournament with the silent auction and raffles. Prizes that would have been awarded to the winning teams will be offered as door prize drawings.
For more information, contact Sara Brooks, Marketing and Development or call 540-343-3241, ext 25.
©2015 Mill Mountain Zoo, P. O. Box 13484, Roanoke, Virginia 24034 - (540) 343-3241
Roanoke Valley Convention and Visitors Bureau
Powered by Exemplum


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Pssst! Pull up a chair, and I'll tell you a secret. You'd better lean in close for this one. Ready? You don't have to do more, be more, have more. Even if we've never met, I know this about you: you're a daughter of God, a holy princess, a woman created with strengths you're yet to fully grasp and a story that's still being written by the divine Author himself.
And if you really take hold of who you are and what you're called to do, there will be no stopping you. That's because there's no stopping Him in you--and He's got bigger plans for your life than you've even imagined. Okay, you've been warned. If you're feeling brave, I dare you to turn the page." - Holly Gerth
This DayBrightener is perfect to position on your desk for an uplifting message each and every day. It features a padded cover, wire coil, 366 date pages, stand-up easel, and beautiful color art. Brighten your day or someone else's with this calendar.
We have a 3-5 day in-house process. There will be an additional 1-7 days for delivery.
**During peak Holiday Seasons (Mother's Day & Christmas) it can take an additional 1-2 business days to get your order shipped.
We do not accept International orders online.
To place an order with an International billing or shipping address:
You will need to order by calling 405-745-1275. Customer Service is available Monday - Friday 8:00-5:00 CST.
Your order will need to ship to a US Destination, such as a freight forwarder. By doing so your order will be eligible for our US shipping rates which often include free shipping.
If you would like for us to ship your order directly to you, you will be charged the actual postage amount. That amount is calculated once your order is picked, packed and ready to ship. International shipping address are excluded from all shipping discounts. All orders shipped to an International location are charged the actual cost of shipping.
Please note that this policy does not include Military Addresses, Guam, Puerto Rico & the US Virgin Islands. We will accept and ship orders to these destinations.
Expedited shipping is unavailable at this time.
Shop Hobby Lobby
Attention Customer Service
7600 A SW 44th St
Oklahoma City, OK 73179
If you wish to exchange an item(s) you ordered for a new one:


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Below is the poem entitled Becoming American which was written by poet
Zart. Please feel free to comment on this poem. However, please remember, PoetrySoup is a place of encouragement and growth.
Read Poems by
Tom Zart
We have always been a nation of immigrants,
Yet immigrants cause us to divide.
Newcomers are welcome when legitimate
For their energy, talents and pride.
To many besides the undocumented
Break our laws despite what they say.
As the anxious by the thousands
Pour over our borders each day.
The absolute one way to bring America to ruin
Is to let it become a clash of nationalities.
Even now as we argue and debate
We're ignoring our long-term realities.
It's time to bring back the melting pot
Or at least an updated application.
For one and all to assimilate and embrace
The laws that sustain our nation.
Everyone must learn about America's heritage
Our democratic principles and freedom of choice.
All must be taught the values by which we're defined
And English both printed word and voice.
We can volunteer to teach English to immigrants
And invite them to our church, synagogue or home.
What each of us does can make a difference
As the seeds of our culture are sown.
A comment has not been posted for this poem. Encourage a poet by being the first to comment.


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This counter service location is the place to go in Fantasyland for hot or cold drinks. They also serve a limited number of breakfast snack items.
Assorted Cereals with Milk - $3.19
Muffin - $2.79
Whole Fruit - $1.29
Minute Maid Lemonade - $2.59
Minute Maid Orange Juice - $2.59
Lemonade Slush - $3.69
Raspberry Lemonade Slush - $3.69
Strawberry Punch - $2.59/$2.89
Iced Coffee - French vanilla, mocha or latte. $3.99
Nestle Hot Cocoa or Hot Tea - $2.09
Coffee (regular or decaf) - $2.09
SmartWater - $3.50
Dasani Bottled Water - $2.50
If a menu is presented here it is for guidance purposes only. Menus can change without notice and at some restaurants daily. If you have specific dietary needs or questions it is best to contact the restaurant directly for information. If you'd like to notify us that a menu has changed, or you can provide the complete information, please let us know through our email form.
Offsite Links (we can not vouch for their accuracy or timeliness)
You can help us keep these guides current. If you see anything incorrect on this page, or if you have additional information that should be added, please fill out our form.


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It's farewell from TiG and hello to new Gloucester Citizen and Gloucestershire Echo websites
Posted: November 12, 2013|
After more than a decade of providing news, sport and entertainment content for the county Thisisgloucestershire is finally winding down to make way for new websites: Gloucestercitizen.co.uk and Gloucestershireecho.co.uk.
From today no new content will be published on TiG and all the news, sport and entertainment will be posted on our new websites.
A new look Stroudlife.co.uk also launches today.
You can also follow the breaking news on our Facebook pages and Twitter profiles:
@Thisisglos will still continue to post news and sports from the new sites.


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Our city is rife with musical talent, with a rich history of encouraging young artists. No organization understands that better than the Cliburn, and it is fitting that we launch this year's Modern series, which celebrates living American composers, with works that were written here in our hometown. Two brilliant composers, who have each chosen to make Fort Worth their home as associate professors at TCU, will showcase their music.
Filter by Event Type
- Exhibitions
- Films
- Performances
- Studio Programs
- Lectures
- Tours
- Member Events
- Gallery Programs
- Cafe Modern
- Shop Modern


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Will he leave Manchester United for the Bundesliga? What do you think?
Hannover? Or even Bayern Munich?
Have your say!]]>
This is just plain crazy!! What an own goal!!
Check it out. http://www.youtube.com/watch?v=5lAWAbvZX54]]>
Some players are known for their hammer-blow free-kick techniques but it seems Bayern Munich star Daniel van Buyten will win that competition after achieving such a clean strike that the ball burst....
Check out the video of the funny incident here:
Borussia Dortmund striker Lucas Barrios has revealed he is considering his future at the club.
Read more: http://www.ontheminute.com/news/news.php?news=35782
Should Borussia Dortmund try to keep Barrios at the club?
Do they really need Barrios?
Have your say!]]>
Do you believe Lustig would be a good signing for Celtic?
Would he fit in at the club?
Have your say!]]>
What next for David Beckham?
Move to Paris St Germain?
Return to Premier League?
Stay in MLS?
Go back to Serie A?
Retire from playing?
What do you think?
Could he even return to Manchester United?
Have your say!]]>
But will he leave the club in January or next summer, or will he remain at the club?
He has been linked with the likes of Bayern Munich, Manchester City and Arsenal. But where will he end up if he leaves?
Manchester City technical director Mike Rigg has confirmed his side's interest in Reus: "I know Marco, because I like him a lot,' Rigg told Bild. "He is one of the most talented players you have in Germany and we have watched him very often."
Have your say!]]>
Adidas announced on Friday that it will continue its partnership Fifa
"[Adidas] enjoys a long term partnership with Fifa as a sponsor and supplier around their events at all levels of the game and we have agreed to continue this partnership," it said in a statement.
"We hope that Fifa will do its best to reach clarity on the allegations soon. The negative tenor of the public debate around Fifa at the moment is neither good for football nor for Fifa including its partners."
Is it time for the general public to get behind TalkSport's Alan Brazil and boycott Adidas and Coca Cola products and drink Pepsi Cola instead and wear Nike sportswear??
I say YES!!
Boycott brands who sponsor the bent and corrupt FIFA!]]>
Major League Soccer outfit Houston Dynamo have denied reports that they have made a move for Hibs striker Derek Riordan.
Read more: http://www.ontheminute.com/news/news.php?news=31473
What do you think?
Should Houston Dynamo make a fresh attempt at signing Riordan from Hibs?]]>
Is he a good signing for Dortmund?
Will he be able to strengthen the Bundesliga champions?
Have your say!]]>
Does Russia deserve to host the 2018 World Cup?
Does Qatar deserve to host the 2022 World Cup?
Have your say!]]>
"Neil Lennon (Celtic manager) said to me I might miss the adulation Celtic players get but I'm not so sure.
"My view is I need a break from it. I've had my experiences of Glasgow and I do need a change.
"There is always someone wanting to have a go at you. I got into a few fights in the past and wish I hadn't. I let my guard down a few times and it cost me.
"But some of the verbal abuse I had to take was really out of order. Because I'm a footballer, people think they are entitled to say what they like and get away with it.
"I'm talking about grown men here. They would shout, 'I hate you' or 'I'm gonna kill you, wee man'.
"There was also a lot worse but I'm not going to go into that."
McGeady claimed his decision to play for the Republic of Ireland rather than Scotland also made him a target for abuse from away supporters.
He told The Herald: "There are a lot of horrible places in Scotland for that type of thing: Tynecastle, Ibrox obviously is always going to be bad with the Celtic-Rangers rivalry, Motherwell, Falkirk.
"Some fans there hate everything Celtic stand for and everything I stand for as an Irish Catholic playing for Celtic.
"It begins in the warm-ups before games with all sorts of stuff being shouted at you, even from little kids."
Boy needs to toughen up. Said he is quitting scotland cos of the abuse or hatred he gets in daily life. What is that? Those russians won't make it any easy on him.]]>
"He [Lehmann] belongs in the Muppet Show, on the couch or in a mental institution."
A true tongue beatdown?]]>
15 uncapped players wow
that is what england should do, dont u agree?


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Is there anything more perfect than Oscar nominee Brad Pitt? He's got the perfect wife, perfect career, perfect kids, perfect smile, perfect muscular physique and … let's stop there, because while we could go on all day, we're pretty sure none of you need convincing. Even his fashion missteps are perfect, in their own special way! It's true. We can't entirely fault Brad for those long bleached blonde locks (it was the '90s) or even the Kate Gosselin-styled 'do (also '90s!). And no one else could rock a scraggly, dreaded beard more grandly than Pitt. Also, most of his, shall we say, less-than-ideal stylings were for a role, or for saving New Orleans, or something. That's why we are awarding Brad Pitt with TheFABlife's prestigious Perfect Hair Award (we'll be on standby if Brad wants to give us an acceptance speech.).
Oh, to be a follicle on that perfectly shaped scalp, or a faint bit of stubble along his perfectly chiseled jawline, but we digress. Check out Brad's Hair-volution through the years and tell us which look is your fave!


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Cold frames have been known as the "poor man's greenhouse".
They're called "cold" because they do not provide any heat internally. Cold frames are warmed by the sun. A benefit of a cold frame is that you can grow cool season vegetables and flowers early in the season, as early as 4-6 weeks before your growing zone is officially frost-free, and on into the winter months.
A cold frame is a great natural way to transition seedlings that you've started indoors. By "transition" we mean giving the seedlings a area with a little more room to grow, preparing them for the harsher conditions of the outside world beyond the greenhouse. Great for collecting warm sunlight and providing protection and ventilation all at once, cold frames can be thought of as a "dorm" for your young plants before they move out on their own into the garden.
These are typically made of a combination of lightweight metal framing and plastic. This gives them great flexibility of use and makes for easy storage in the off-season.
But there are also other, simpler cold frame options available for gardeners in small spaces. They can be made very simply from scrap lumber or hay bales covered with old window sashes. Using four rectangular bales of hay and an intact window frame. Arrange the hay bales so that they form a square with a space in the center of a size that can be covered by laying the window frame flat on top. The hay will provide insulation and the window frame will let in light. Just remember when it's sunny to prop the window open with a brick to provide adequate ventilation this way you don't "cook" your plants, and don't forget to water.
Cold frames and the temperatures
The small growing tool similar to a box, known as a cold frame, to meet your needs in growing seeds, needs to use the heat and the cold. It will also extend your gardening season. Banking helps insulate the cold frame from heat and cold, is done but putting dirt along the edges of the box.
Preventing weather from affecting seedlings and your plants, a helpful tip would be to place a large sheet of paper, and a way of knowing if the cold weather will be able to get to your plants and seedlings, is if you can pull that same piece of paper out when the lid is closed. If the cold weather is able to get to your plants and seedlings, which will more likely shorten their lives a little more.
If temperatures below twenty or heavy frosts are coming your way, a good idea would be to at the top of the cold frame stopping the cold air to transfer in through the glass to the cold frame, place a cloth over top it. Also when you start your gardens early seeing radishes, lettuce and what ever you planted, pop out of the soil, during early spring, the temperatures are very cold, and protecting your plants by using the cloth would be a very smart thing to do.
Closing the frame before the sun goes down, and then place a blanket on the cold frame, leaving it like this until the morning will give extra protection, and will keep the heat in the cold frame for your plants. Having a cold frame that is as large as you want, say one foot by one foot and can handle with a lid, keep in mind.
A great way to have a variety of vegetables that are able to enjoy by June, is that for those avid gardeners, build your self a cold frame, which is five foot by two foot. If you are a person that is growing plants, or seedlings, that are going to require temperatures that are much higher, or changing a cold frame to a hot bed, by adding light and also heat.
However hot beds are highly more expensive and are fancier. Some, are not though, it depends on the types of plants you would like to start. It also depends what the environment is like around where you live. By using bricks to frame that box of a hot bed, is a similar way as to the cold frame. The bricks will act as if it is a sun collector, or holder. It will hold the heat and also hold the temperature, though out the night, longer. Also, the hot bed will be at I higher temperature, than as the cold frame.


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August 2, 20151:48 AM ET
NEW YORK (AP) — President Barack Obama will impose even steeper cuts on greenhouse gas emissions from U.S. power plants than previously expected, senior administration officials said Sunday, in what the president called the most significant step the U.S. has ever taken to fight global warming.
August 1, 20158:41 PM ET
WASHINGTON (AP) — Vice President Joe Biden's associates have resumed discussions about a 2016 presidential run after largely shelving such deliberations during his son's illness and following his death earlier this year. But Biden has yet to tell his staff whether he will run or personally ask them to do any planning for a potential campaign, according to several people close to the vice president.
August 1, 201511:18 PM ET
BALMA, France (AP) — A wing flap suspected to be from the missing Malaysia Airlines Flight 370 on Saturday arrived at a French military testing facility where it will be analyzed by experts.
August 1, 201511:10 PM ET
SELMA, Ala. (AP) — Protest marches have been part of Selma's civil rights fabric since 1965, but an 860-mile trek to Washington had a minister leaning on the Bible for heavenly support Saturday.
August 2, 20151:42 AM ET
MEXICO CITY (AP) — A photographer for the Mexican investigative magazine Proceso, who had fled his home state after being harassed, was among five people found slain early Saturday in an apartment in Mexico City, according to the magazine.
August 2, 20152:16 AM ET
RIO DE JANEIRO (AP) — Ronda Rousey defended her bantamweight title by knocking out Bethe Correia only 34 seconds into the first round at UFC 190 on Saturday night.
August 1, 20158:28 PM ET
LOS ANGELES (AP) — Clayton Kershaw and Mike Trout made history at Dodger Stadium on Saturday. It was the first time that a reigning MVP from the National League faced a reigning MVP from the American League.
August 2, 201512:56 AM ET
ARLINGTON, Texas (AP) — Cole Hamels understood not getting to finish the eighth inning of his debut with the Texas Rangers.
August 2, 20151:40 AM ET
SEATTLE (AP) — Right on the heels of signing quarterback Russell Wilson to a contract extension, the Seattle Seahawks have locked up All-Pro middle linebacker Bobby Wagner.
August 1, 20154:03 PM ET
FOXBOROUGH, Mass. (AP) — Two things were certain Saturday when the New England Patriots put on pads for the first time at training camp: The home fans sure do love Tom Brady, and the quarterback's suspension and court case haven't affected his accuracy.


text: With a little more fanfare and a team that didn't have some inexplicably bad nights, Porter might just be the leading candidate for Big East player of the year instead of merely in the mix. He's that good. He's just sort of unassuming about it. Not in this game. Easily the best player of the match, Porter eventually took over, finishing with 21 points and seven rebounds.


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Lemon coconut bars (no bake)
I love these old-fashioned, citrusy, sweet little bars and they're so easy to make. I whip up a batch, freeze them and take them out to defrost for dessert emergencies (no really! There is such a thing, you know there is). You can also swap the lemon juice for lime for an even zestier flavour.
I made this lot a while back in summer.
80g unsalted butter
3/4 cup skim or full fat sweetened condensed milk
1 x 20ml tblspn freshly squeezed lemon juice
1/2 tspn finely grated lemon zest
250g packet Arnott's Nice biscuits, Milk Arrowroot biscuits or other plain, sweet biscuit
1 cup organic desiccated coconut
Lemon Icing
2 cups pure icing sugar, sifted
3 x 20ml tblspns freshly squeezed lemon juice + 20mls more, if needed
2 x 20ml tblspns organic desiccated coconut
Lemon zest (optional)
Grease a non-stick 18cm by 28cm baking dish and line base and sides with baking paper.
Heat butter and condensed milk in a medium, heavy based saucepan over low/medium heat, stirring until butter has melted and mixture is smooth. Take off the hotplate and add lemon juice and lemon zest (if using), whisking to combine. Set aside.
Finely crush biscuits using a food processor or alternately, place biscuits in two freezer bags and bash with a rolling pin (the crumbs might be a bit coarser if you do it this way).
Stir crushed biscuits and coconut into condensed milk mixture until combined well. The mixture will be quite wet to start with – use your hands to press the mixture into prepared pan and refrigerate for around 15 minutes.
Remove base from the fridge and prepare icing (make just before you use it as it hardens quite quickly). Spread icing evenly over slice using a flat bladed knife then sprinkle with extra coconut and lemon zest, if using.
Refrigerate slice until firm then remove from the pan and cut into pieces. Store slice in an airtight container in the refrigerator or wrap individually in plastic wrap and store in freezer. Defrost in the fridge then leave out at room temperature for 15 minutes or so before eating.
Lemon Icing
Combine sifted icing sugar and lemon juice in a small bowl and stir until smooth. Add more juice if needed.
Makes 16 pieces
Adapted from: Exclusively Food
June 18, 2012
These nobaked lemon bars are right up my alley!
June 18, 2012
I bookmarked the recipe before I even finished reading the recipe. This is a definite must have!
June 19, 2012
Emma-I just love these no-bake desserts, especially yummy lemon bars…and no bake?
Couldn't ask for any other dessert than cold gelato, or a fruit sorbe in the summer heat
Thanks for sharing the great recipe:DDD
July 13, 2012
These look absolutely lovely. I love anything citrus-y! Thanks for sharing.


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The English Premier League provides the biggest stage in the world for players, managers, and coaches alike to showcase their various skills and talents. Audiences in the millions around the world watch teams and players, as fans tune into whatever … Continue reading
Throughout the season, the Premier League keeps track of which clubs have the best behaved fans as well as the worst behaved fans. Last year, Chelsea was voted the worst behaved fans especially because of the way they abused Avram … Continue reading
Plans are being finalized for the 2009 Premier League Asia Trophy. So far, Chelsea, West Ham United and Hull City have been invited to participate in the tournament which is likely to be held in China, in either Beijing or … Continue reading
I admit it. I have a soft spot for underdogs. Three years ago, I was enamored by Wigan's brilliant beginning to the season where they surprised so many teams and fans by playing attacking football. Two years ago, it was … Continue reading
So, how many people thought Hull City would be Premiership cannon fodder, this seasons Derby County, bravely battling against the odds in a futile struggle that would ultimately lead to relegation. If so, how many had actually seen Hull City … Continue reading
• Arsenal's 2-1 victory over Manchester United at the weekend was one of the games of the season so far and Arsene Wenger's side proved a lot of people wrong. Not only did they show their outstanding technical ability but … Continue reading
Just as it's difficult to predict who will win the Premier League race this year, it's going to be even harder to pick which three clubs will be relegated. After watching all of the teams play, none of them look … Continue reading
Tomorrow in the United States will be the biggest day in the history of the country for several years. But if you had one choice between the candidates, who would you want to win the race? <a href="http://answers.polldaddy.com/poll/1070829/" >If you … Continue reading
This weekend we were graced with another very entertaining and competitive Premier League weekend. At this rate, we're well on course for one of the most exciting Premier League seasons in recent memory. Here are ten reasons why: No more … Continue reading
Which Premier League club has the highest percentage of foreigners? Who has the youngest squad? And who has the oldest squad? Read the following top 10 statistics to find the answers to those questions and many more. Oldest squad: Hull … Continue reading
How are attendances at Premier League clubs being affected, if at all, by the Credit Crunch this season? Based on research compiled by EPL Talk comparing the percentage difference between the average attendance season to date and last season's average … Continue reading
In 1986, an English pop band named The Housemartins released their debut album entitled "London 0 Hull 4," which perfectly summed up what the four northern lads thought of music from London as well as their contention that they were … Continue reading
EPL Talk has a list of the best supported clubs in the Premier League for the 2008/2009 season thus far based on the percentage of seats filled in a football stadium. So, for example, Arsenal's ground has a capacity of … Continue reading
With the season well underway and the league table starting to take some sort of shape, it is quite a surprise to see an unfamiliar team sitting in third place in the league. At the start of the season everyone … Continue reading
Follow West Ham United against Bolton Wanderers live and online today via the EPL Talk Chat featuring football fans discussing the match from around the world. We will also keep you up to date on all games on this Sunday … Continue reading
Who would have expected Hull City — tipped by many for relegation, myself included — to go to the Emirates Stadium and pull off one of the shocks of the season against the mighty Arsenal? Every player on the Hull … Continue reading
Before I write, I want to thank everyone for the turnout this weekend for the EPL Talk Chat. You honestly have no idea how happy it made me. Anyways enough of the gushing, back to the meat of this post. … Continue reading
Some of the biggest storylines from the opening two weeks of the new Premier League season have been the surprising displays by Hull, Stoke, Middlesbrough and Newcastle. All four teams are playing today in matches that will show whether their … Continue reading


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Feeling a Draft
2014-05-12 12:00:00
A full Texas-based recap of the NFL Draft.
Here at Dave Campbell's Texas Football, the NFL Draft is an especially meaningful event. Because of how we're structured – covering high school football, recruiting, college football and pro football in Texas – the players taken in the Draft are often guys that we've been watching for years, who have appeared in our magazine and on our site long before having their name called at Radio City Music Hall.
That's part of why we watch the Draft with such interest – we cover football in Texas, and as always, Texas has a lot to say about the NFL Draft.
And the 2014 NFL Draft was no different, as there were plenty of Texas connections that were selected to play in the pros – plus, of course, the Houston Texans and Dallas Cowboys' selections.
Without further ado, DCTF's all-encompassing Texas NFL Draft review.
First Round
No. 1, Houston Texans: DE Jadeveon Clowney, South Carolina
The Texans have said for a while that they want to take the best player available with the No. 1 overall pick, and it's hard to argue against the menacing Clowney.
No. 6, Atlanta Falcons: OL Jake Matthews, Texas A&M (Fort Bend Elkins HS)
Both the first Texas college player and the first Texas high school product came off the board when Matthews went to the Falcons, following in the footsteps of his father, Hall of Famer Bruce Matthews.
No. 7, Tampa Bay Buccaneers: WR Mike Evans, Texas A&M (Galveston Ball)
It was back-to-back Aggies and back-to-back Texas high schoolers, as the Bucs took the outstanding wide receiver from Galveston by way of College Station.
No. 8, Cleveland Browns: CB Justin Gilbert, Oklahoma State (Huntsville)
The Browns traded up to get the Huntsville product, who dazzled both defensively and on special teams for Oklahoma State.
No. 16, Dallas Cowboys: OL Zack Martin, Notre Dame
There were rumblings that the Cowboys could take Texas A&M QB Johnny Manziel with this pick, but Dallas went with the more conservative pick by nabbing Martin, a sensational lineman with great pedigree.
No. 22, Cleveland Browns: QB Johnny Manziel, Texas A&M (Kerrville Tivy)
Johnny Football's draft slide finally ended when Cleveland traded up again to grab Manziel, making him the face of the franchise and an instant favorite in the CLE.
No. 25, San Diego Chargers: CB Jason Verrett, TCU
DCTF's pick for the Defensive Player of the Year in 2013 went to the SuperChargers, where it's easy to see him following in the footsteps of Quentin Jammer.
Second Round
No. 33, Houston Texans: OL Xavier Su'a-Filo, UCLA
While many speculated that the Texans would use this pick on a quarterback, they instead went with Su'a-Filo, who shined on the Bruins' offensive line.
No. 34, Dallas Cowboys: DE Demarcus Lawrence, Boise State
The Cowboys needed someone up font defensively to help replace DeMarcus Ware, and they think they found him in Lawrence, who was equal parts sensational and troubled at Boise State.
No. 36, Oakland Raiders: QB Derek Carr, Fresno State (Fort Bend Clements)
You may not remember, but Carr started at Clements before transferring to California for his senior year. He dazzled at Fresno State, and now he won't go far for his pro career, shifting just south to Oakland.
No. 43, New York Giants: OL Weston Richburg, Colorado State (Bushland)
The big boy from Bushland was the next up on the Texas high school football parade, heading to the Cowboys' division rival.
No. 49, New York Jets: TE Jace Amaro, Texas Tech (San Antonio MacArthur)
After a breakout junior season with the Red Raiders, the MacArthur product went in the second round to the J-E-T-S Jets Jets Jets.
Third Round
No. 65, Houston Texans: TE C.J. Fiedorowicz, Iowa
And still, the Texans waited to take a quarterback, instead picking Fiedorowicz, who logged at least one catch in 31 consecutive games at Iowa.
No. 69, Tampa Bay Buccaneers: RB Charles Sims, West Virginia (Hou. Westbury)
A man with more than one Texas connection, Sims played for three years at Houston after shining at Westbury, then transferred to West Virginia for his final year of eligibility. Now, he's heading to Florida.
No. 76, Detroit Lions: OL Travis Swanson, Arkansas (Kingwood)
A stalwart on the Arkansas offensive line for years, the Kingwood product is heading to Detroit to help protect fellow Texas high school product QB Matt Stafford.
No. 83, Houston Texans: NT Louis Nix, Notre Dame
More Domers heading to the Lone Star State, as the Texans beef up their defensive front with the talented Nix.
No. 86, Philadelphia Eagles: WR Josh Huff, Oregon (Aldine Nimitz)
A superstar at Nimitz, Huff went on to a strong career at Oregon, and now he'll be reunited with his old coach Chip Kelly in Philadelphia.
No. 87, Kansas City Chiefs: CB Phillip Gaines, Rice (Converse Judson)
A member of DCTF's All-Texas College Team, Gaines was sensational for the Owls after a terrific career at Judson.
No. 99, Baltimore Ravens: TE Crockett Gilmore, Colorado State (Bushland)
If you had Bushland in your pool for "Which Texas high school will have two players selected in the top 100 picks", come collect your winnings.
Fourth Round
No. 119, Dallas Cowboys: OLB Anthony Hitchens, Iowa
No. 122, Tennessee Titans: DB Marqueston Huff, Wyoming (Texarkana Liberty-Eylau)
No. 135, Houston Texans: QB Tom Savage, Pittsburgh
No. 140, New England Patriots: OL Cameron Fleming, Stanford (Cy Creek)
Fifth Round
No. 142, Washington Redskins: WR Ryan Grant, Tulane (Beaumont West Brook)
No. 146, Dallas Cowboys: WR Devin Street, Pittsburgh
No. 153, Buffalo Bills: OL Cyril Richardson, Baylor (North Crowley)
Sixth Round
No. 177, Houston Texans: DE Jeoffrey Pagan, Alabama
No. 180, San Francisco 49ers: CB Kenneth Acker, SMU
No. 181, Houston Texans: RB Alfred Blue, LSU
No. 186, Washington Redskins: RB Lache Seastrunk, Baylor (Temple)
No. 197, Green Bay Packers: CB Demetri Goodson, Baylor (Klein Collins)
No. 201, San Diego Chargers: RB Marion Grice, Arizona State (Aldine Nimitz)
No. 210, New York Jets: DE I.K. Enemkpali, Louisiana Tech (Pflugerville)
No. 211, Houston Texans: FB Jay Prosch, Auburn
No. 214, St. Louis Rams: QB Garrett Gilbert, SMU (Lake Travis)
Seventh Round
No. 216, Houston Texans: CB Andre Hal, Vanderbilt
No. 231, Dallas Cowboys: DE Ben Gardner, Stanford
No. 238, Dallas Cowboys: LB Will Smith, Texas Tech
No. 240, San Diego Chargers: WR Tevin Reese, Baylor (Temple)
No. 242, Denver Broncos: LB Corey Nelson, Oklahoma (Dallas Skyline)
No. 248, Dallas Cowboys: DB Ahmad Dixon, Baylor (Hewitt Midway)
No. 249, St. Louis Rams: DE Michael Sam, Missouri (Hitchcock)
No. 251, Dallas Cowboys: DT Ken Bishop, Northern Illinois
No 254, Dallas Cowboys: CB Terrance Mitchell, Oregon
No. 256, Houston Texans: DB Lonnie Ballentine, Memphis
Greg Tepper is the managing editor of Dave Campbell's Texas Football and TexasFootball.com.
He can be reached via e-mail, via Twitter (@Tepper) and via the DCTF Facebook page.
If you would like to report inappropriate behavior within the Facebook commenting system, please email email@example.com and we will review your request.


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Industrial-organizational (I-O) psychology is the scientific study of the workplace. Rigor and methods of psychology are applied to issues of critical relevance to business, including talent management, coaching, assessment, selection, training, organizational development, performance, and work-life balance.
Our world headquarters is centrally located in Topeka, KS, facilitating easy travel to all parts of the country. And Topeka enjoys close proximity to Kansas City and Lawrence, home of the University of Kansas, providing our Associates with multiple communities in which to reside.
Overview: The Organization Development Manager at Payless Holdings, Inc. is member of a high-performing Organization Development/Learning & Development team. The mission of the OD team is to build effective and efficient HR solutions that drive organization development and effectiveness through structure, process, strategy and the selection, development, engagement and retention of top talent. The PSS OD team operates as a center of excellence and resource for all of the business units. Job Responsibilities: Primary responsibilities for this role will include leading strategy and process, and managing a team to complete projects in the areas of:
Other responsibilities include working with HR generalists and business leaders on:
Qualified, interested applicants may apply clicking on the URL listed below:


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Miller Real Estate Group, Inc.
Complete Real Estate Service Sales And Property Management. The professional team of Miller Real Estate is here to serve all your real estate needs. Offering a wide selection of homes, acreages, farms, land, rural, commerial properties and other real estate in the Fort Leonard Wood, Waynesville, St. Robert, Missouri areas and thoughtout Pulaski County, in the beautiful rolling Ozark Hills of MIssouri. Let us help you to find your home in the Ozarks.
We have been in the real estate business in this area for more than 50 years. We have a close relationship with this area and can assist the most discriminating buyers. We have the knowledge needed to handle all real estate transactions. Call for an appointment today!Homes • Repossessed • New Construction • Commercial Property • Acreage • Rentals
Our LocationLocated behind
the courthouse.GO >>


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Coaching Packages
Check our coaching plans and select one of them based on your needs. If you are serious about your performance, this is the place for you! Contact us today and start training scientifically!
Check our coaching plans and select one of them based on your needs. If you are serious about your performance, this is the place for you! Contact us today and start training scientifically!
Historically, athletes and coaches have been monitoring training and racing routines through the use of paper logs. These offer info like distance ridden, nutrition, and effort levels based on scales like Borg 10 or 20-points rating of perceived exertion (Borg RPE). However technology showed that more could and should be recorded and analyzed. In 1982, the Finnish company Polar invented wireless heart rate monitors and many new training methodologies were proposed and used for years. Nevertheless, heart rate is subject to baseline variations under different conditions such as stress, hydration level, and sleep quality. These limitations had to be overcome and they actually pushed the development of portable on-bike power meters.
All athletes should log as much information as possible in every training or race workout they complete. But what should be recorded and how to do it? Both objective and subjective data should be registered. In another article I have listed many tips to make sure you always get consistent objetive data. However training is not only about power, heart rate, pace, speed, cadence, and altimetry. Other aspects should also be monitored and logged after every workout. Let's discuss each one.
40 kilometer TT - A 40 km (24.8-mile) solo race against the clock. Time trials are often referred to as "the race of truth."
Acute Training Load (ATL) - The overall quantity (i.e., combination of frequency, duration, and intensity) of training that you have performed recently (during the past week or two). See also Chronic Training Load (CTL).
Would you like to buy one of the FCA Sports apparel options? Contact us today! Still in doubt? Check out our great cycling jerseys and t-shirts.
What is Strava? Strava is a community of athletes from all over the world. Strava lets you experience what they call social fitness - connecting and competing with each other via mobile and online apps.
Working with athletes presents day-to-day challenges. Both parts are always learning something new and trying to do a better job today than yesterday. One early area that frequently has a steep learning curve is how to correctly operate modern sports (eg. bike) computers or watches. Summarizing many past experiences with my athletes, I decided to write-up this short guide of recommended practices for consistent sports data generation.


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tuit.in URL shortener 1.1.1-signed No Restart
by Bruno Marques
This is the tuit.in URL shortener add-on. With this add-on you can shorten your URL without leaving the current page.
All your URL's shortened with tuit.in add-on will be tracked by tuit.in analytics solution to give you advanced statistics.
This add-on has been preliminarily reviewed by Mozilla. Learn more
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- Liver cirrhosis (2)
- Alcoholic liver disease (1)
- Fibrotest (1)
- Genetic testing (1)
- Hepatitis (1)
- Hepatotoxicity (1)
- Interleukin-22 (1)
- A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants (2010)
- Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease inhibitor, telaprevir. Variant fitness was estimated using a model in which variants were selected by competition for shared limited replication space. Fitness was represented in the absence of telaprevir by different variant production rate constants and in the presence of telaprevir by additional antiviral blockage by telaprevir. Model parameters, including rate constants for viral production, clearance, and effective telaprevir concentration, were estimated from 1) plasma HCV RNA levels of subjects before, during, and after dosing, 2) post-dosing prevalence of plasma variants from subjects, and 3) sensitivity of variants to telaprevir in the HCV replicon. The model provided a good fit to plasma HCV RNA levels observed both during and after telaprevir dosing, as well as to variant prevalence observed after telaprevir dosing. After an initial sharp decline in HCV RNA levels during dosing with telaprevir, HCV RNA levels increased in some subjects. The model predicted this increase to be caused by pre-existing variants with sufficient fitness to expand once available replication space increased due to rapid clearance of wild-type (WT) virus. The average replicative fitness estimates in the absence of telaprevir ranged from 1% to 68% of WT fitness. Compared to the relative fitness method, the in vivo estimates from the viral dynamic model corresponded more closely to in vitro replicon data, as well as to qualitative behaviors observed in both on-dosing and long-term post-dosing clinical data. The modeling fitness estimates were robust in sensitivity analyses in which the restoration dynamics of replication space and assumptions of HCV mutation rates were varied.
- Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors (2010)
- Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined. Virus cell entry involves human scavenger receptor class B type I (SR-BI), CD81, claudin-1 and occludin. Among these, at least CD81 and occludin are utilized in a highly species-specific fashion, thus contributing to the narrow host range of HCV. We adapted HCV to mouse CD81 and identified three envelope glycoprotein mutations which together enhance infection of cells with mouse or other rodent receptors approximately 100-fold. These mutations enhanced interaction with human CD81 and increased exposure of the binding site for CD81 on the surface of virus particles. These changes were accompanied by augmented susceptibility of adapted HCV to neutralization by E2-specific antibodies indicative of major conformational changes of virus-resident E1/E2-complexes. Neutralization with CD81, SR-BI- and claudin-1-specific antibodies and knock down of occludin expression by siRNAs indicate that the adapted virus remains dependent on these host factors but apparently utilizes CD81, SR-BI and occludin with increased efficiency. Importantly, adapted E1/E2 complexes mediate HCV cell entry into mouse cells in the absence of human entry factors. These results further our knowledge of HCV receptor interactions and indicate that three glycoprotein mutations are sufficient to overcome the species-specific restriction of HCV cell entry into mouse cells. Moreover, these findings should contribute to the development of an immunocompetent small animal model fully permissive to HCV.
- The INCA trial (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites): study protocol for a randomized controlled trial (2015)
- BACKGROUND: Patients with liver cirrhosis have a highly elevated risk of developing bacterial infections that significantly decrease survival rates. One of the most relevant infections is spontaneous bacterial peritonitis (SBP). Recently, NOD2 germline variants were found to be potential predictors of the development of infectious complications and mortality in patients with cirrhosis. The aim of the INCA (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites) trial is to investigate whether survival of this genetically defined high-risk group of patients with cirrhosis defined by the presence of NOD2 variants is improved by primary antibiotic prophylaxis of SBP. METHODS/DESIGN: The INCA trial is a double-blind, placebo-controlled clinical trial with two parallel treatment arms (arm 1: norfloxacin 400 mg once daily; arm 2: placebo once daily; 12-month treatment and observational period). Balanced randomization of 186 eligible patients with stratification for the protein content of the ascites (<15 versus ≥15 g/L) and the study site is planned. In this multicenter national study, patients are recruited in at least 13 centers throughout Germany. The key inclusion criterion is the presence of a NOD2 risk variant in patients with decompensated liver cirrhosis. The most important exclusion criteria are current SBP or previous history of SBP and any long-term antibiotic prophylaxis. The primary endpoint is overall survival after 12 months of treatment. Secondary objectives are to evaluate whether the frequencies of SBP and other clinically relevant infections necessitating antibiotic treatment, as well as the total duration of unplanned hospitalization due to cirrhosis, differ in both study arms. Recruitment started in February 2014. DISCUSSION: Preventive strategies are required to avoid life-threatening infections in patients with liver cirrhosis, but unselected use of antibiotics can trigger resistant bacteria and worsen outcome. Thus, individualized approaches that direct intervention only to patients with the highest risk are urgently needed. This trial meets this need by suggesting stratified prevention based on genetic risk assessment. To our knowledge, the INCA trial is first in the field of hepatology aimed at rapidly transferring and validating information on individual genetic risk into clinical decision algorithms. TRIAL REGISTRATIONS: German Clinical Trials Register DRKS00005616 . Registered 22 January 2014. EU Clinical Trials Register EudraCT 2013-001626-26 . Registered 26 January 2015.
- Baseline MELD score predicts hepatic decompensation during antiviral therapy in patients with chronic hepatitis C and advanced cirrhosis (2013)
- Background and Aims: In patients with advanced liver cirrhosis due to chronic hepatitis C virus (HCV) infection antiviral therapy with peginterferon and ribavirin is feasible in selected cases only due to potentially life-threatening side effects. However, predictive factors associated with hepatic decompensation during antiviral therapy are poorly defined. Methods: In a retrospective cohort study, 68 patients with HCV-associated liver cirrhosis (mean MELD score 9.18±2.72) were treated with peginterferon and ribavirin. Clinical events indicating hepatic decompensation (onset of ascites, hepatic encephalopathy, upper gastrointestinal bleeding, hospitalization) as well as laboratory data were recorded at baseline and during a follow up period of 72 weeks after initiation of antiviral therapy. To monitor long term sequelae of end stage liver disease an extended follow up for HCC development, transplantation and death was applied (240weeks, ±SD 136weeks). Results: Eighteen patients (26.5%) achieved a sustained virologic response. During the observational period a hepatic decompensation was observed in 36.8%. Patients with hepatic decompensation had higher MELD scores (10.84 vs. 8.23, p<0.001) and higher mean bilirubin levels (26.74 vs. 14.63 µmol/l, p<0.001), as well as lower serum albumin levels (38.2 vs. 41.1 g/l, p = 0.015), mean platelets (102.64 vs. 138.95/nl, p = 0.014) and mean leukocytes (4.02 vs. 5.68/nl, p = 0.002) at baseline as compared to those without decompensation. In the multivariate analysis the MELD score remained independently associated with hepatic decompensation (OR 1.56, 1.18–2.07; p = 0.002). When the patients were grouped according to their baseline MELD scores, hepatic decompensation occurred in 22%, 59%, and 83% of patients with MELD scores of 6–9, 10–13, and >14, respectively. Baseline MELD score was significantly associated with the risk for transplantation/death (p<0.001). Conclusions: Our data suggest that the baseline MELD score predicts the risk of hepatic decompensation during antiviral therapy and thus contributes to decision making when antiviral therapy is discussed in HCV patients with advanced liver cirrhosis.
- Altered mucosal immune response after acute lung injury in a murine model of Ataxia Telangiectasia (2014)
- Background: Ataxia telangiectasia (A-T) is a rare but devastating and progressive disorder characterized by cerebellar dysfunction, lymphoreticular malignancies and recurrent sinopulmonary infections. In A-T, disease of the respiratory system causes significant morbidity and is a frequent cause of death. Methods: We used a self-limited murine model of hydrochloric acid-induced acute lung injury (ALI) to determine the inflammatory answer due to mucosal injury in Atm (A-T mutated)- deficient mice (Atm−/−). Results: ATM deficiency increased peak lung inflammation as demonstrated by bronchoalveolar lavage fluid (BALF) neutrophils and lymphocytes and increased levels of BALF pro-inflammatory cytokines (e.g. IL-6, TNF). Furthermore, bronchial epithelial damage after ALI was increased in Atm−/− mice. ATM deficiency increased airway resistance and tissue compliance before ALI was performed. Conclusions: Together, these findings indicate that ATM plays a key role in inflammatory response after airway mucosal injury.
- Interobserver agreement of Thyroid Imaging Reporting and Data System (TIRADS) and strain elastography for the assessment of thyroid nodules (2013)
- Background: Thyroid Imaging Reporting and Data System (TIRADS) was developed to improve patient management and cost-effectiveness by avoiding unnecessary fine needle aspiration biopsy (FNAB) in patients with thyroid nodules. However, its clinical use is still very limited. Strain elastography (SE) enables the determination of tissue elasticity and has shown promising results for the differentiation of thyroid nodules. Methods: The aim of the present study was to evaluate the interobserver agreement (IA) of TIRADS developed by Horvath et al. and SE. Three blinded observers independently scored stored images of TIRADS and SE in 114 thyroid nodules (114 patients). Cytology and/or histology was available for all benign (n = 99) and histology for all malignant nodules (n = 15). Results: The IA between the 3 observers was only fair for TIRADS categories 2–5 (Coheńs kappa = 0.27,p = 0.000001) and TIRADS categories 2/3 versus 4/5 (ck = 0.25,p = 0.0020). The IA was substantial for SE scores 1–4 (ck = 0.66,p<0.000001) and very good for SE scores 1/2 versus 3/4 (ck = 0.81,p<0.000001). 92–100% of patients with TIRADS-2 had benign lesions, while 28–42% with TIRADS-5 had malignant cytology/histology. The negative-predictive-value (NPV) was 92–100% for TIRADS using TIRADS-categories 4&5 and 96–98% for SE using score ES-3&4 for the diagnosis of malignancy, respectively. However, only 11–42% of nodules were in TIRADS-categories 2&3, as compared to 58–60% with ES-1&2. Conclusions: IA of TIRADS developed by Horvath et al. is only fair. TIRADS and SE have high NPV for excluding malignancy in the diagnostic work-up of thyroid nodules.
- Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis (2010)
- Background: FibroTest (FT) is the most frequently used serum fibrosis marker and consists of an algorithm of five fibrosis markers (alfa2-macroglobulin, apolipoproteinA1, haptoglobin, GGT, bilirubin). The Enhanced Liver Fibrosis (ELF) test consists of an algorithm of three fibrosis markers (hyaluronic acid, amino-terminal propeptide-of-type-III-collagen, tissue-inhibitor of matrix-metaloproteinase-1). While a systematic review has shown comparable results for both individual markers, there has been no direct comparison of both markers. Methods: In the present study, the ELF-test was analyzed retrospectively in patients with chronic liver disease, who received a liver biopsy, transient elastography (TE) and the FibroTest using histology as the reference method. Histology was classified according to METAVIR and the Ludwig's classification (F0-F4) for patients with chronic hepatitis C and B virus (HCV, HBV) infection and primary biliary cirrhosis (PBC), respectively. Results: Seventy-four patients were analysed: 36 with HCV, 10 with HBV, and 28 with PBC. The accuracy (AUROC) for the diagnosis of significant fibrosis (F[greater than or equal to]2) for ELF and FibroTest was 0.78 (95%CI:0.67-0.89) and 0.69 (95%-CI:0.57-0.82), respectively (difference not statistically significant, n.s.). The AUROC for the diagnosis of liver cirrhosis was 0.92 (95%CI:0.83-1,00), and 0.91 (95%CI:0.83-0.99), respectively (n.s.). For 66 patients with reliable TE measurements the AUROC for the diagnosis of significant fibrosis (cirrhosis) for TE, ELF and FT were 0.80 (0.94), 0.76 (0.92), and 0.67 (0.91), respectively (n.s.). Conclusion: FibroTest and ELF can be performed with comparable diagnostic accuracy for the non-invasive staging of liver fibrosis. Serum tests are informative in a higher proportion of patients than transient elastography.
- Wie wirksam sind neue Therapien für Hepatitis C? : Mathematische Modellierung charakterisiert den individuellen Behandlungserfolg (2009)
- Die derzeitige Therapie der chronischen Hepatitis C ist komplex und mit zahlreichen Nebenwirkungen assoziiert. Um den Therapieerfolg frühzeitig vorhersagen zu können und die Behandlung individuell zu optimieren, greifen Forscher des Frankfurter Leberzentrums auf mathematische Modellierung zurück. ...
- Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study (2012)
- Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease. Systematic analysis of serum IL-22 in relation to morbidity and mortality of patients with advanced liver cirrhosis has not been performed so far. Methods: This is a prospective cohort study including 120 liver cirrhosis patients and 40 healthy donors to analyze systemic levels of IL-22 in relation to survival and hepatic complications. Results: A total of 71% of patients displayed liver cirrhosis-related complications at study inclusion. A total of 23% of the patients died during a mean follow-up of 196 +/- 165 days. Systemic IL-22 was detectable in 74% of patients but only in 10% of healthy donors (P <0.001). Elevated levels of IL-22 were associated with ascites (P = 0.006), hepatorenal syndrome (P <0.0001), and spontaneous bacterial peritonitis (P = 0.001). Patients with elevated IL-22 (>18 pg/ml, n = 57) showed significantly reduced survival compared to patients with regular ([less than or equal to]18 pg/ml) levels of IL-22 (321 days versus 526 days, P = 0.003). Other factors associated with overall survival were high CRP ([greater than or equal to]2.9 mg/dl, P = 0.005, hazard ratio (HR) 0.314, confidence interval (CI) (0.141 to 0.702)), elevated serum creatinine (P = 0.05, HR 0.453, CI (0.203 to 1.012)), presence of liver-related complications (P = 0.028, HR 0.258 CI (0.077 to 0.862)), model of end stage liver disease (MELD) score [greater than or equal to]20 (P = 0.017, HR 0.364, CI (0.159 to 0.835)) and age (P = 0.011, HR 1.047, CI (1.011 to 1.085)). Adjusted multivariate Cox proportional-hazards analysis identified elevated systemic IL-22 levels as independent predictors of reduced survival (P = 0.007, HR 0.218, CI (0.072 to 0.662)). Conclusions: In patients with liver cirrhosis, elevated systemic IL-22 levels are predictive for reduced survival independently from age, liver-related complications, CRP, creatinine and the MELD score. Thus, processes that lead to a rise in systemic interleukin-22 may be relevant for prognosis of advanced liver cirrhosis.
- PEG-IFN alpha but not ribavirin alters NK cell phenotype and function in patients with chronic hepatitis C (2014)
- Background: Ribavirin (RBV) remains part of several interferon-free treatment strategies even though its mechanisms of action are still not fully understood. One hypothesis is that RBV increases responsiveness to type I interferons. Pegylated Interferon alpha (PEG-IFNa) has recently been shown to alter natural killer (NK) cell function possibly contributing to control of hepatitis C virus (HCV) infection. However, the effects of ribavirin alone or in combination with IFNa on NK cells are unknown. Methods: Extensive ex vivo phenotyping and functional analysis of NK cells from hepatitis C patients was performed during antiviral therapy. Patients were treated for 6 weeks with RBV monotherapy (n = 11), placebo (n = 13) or PEG-IFNa-2a alone (n = 6) followed by PEG-IFNa/RBV combination therapy. The effects of RBV and PEG-IFNa-2a on NK cells were also studied in vitro after co-culture with K562 or Huh7.5 cells. Results: Ribavirin monotherapy had no obvious effects on NK cell phenotype or function, neither ex vivo in patients nor in vitro. In contrast, PEG-IFNa-2a therapy was associated with an increase of CD56bright cells and distinct changes in expression profiles leading to an activated NK cell phenotype, increased functionality and decline of terminally differentiated NK cells. Ribavirin combination therapy reduced some of the IFN effects. An activated NK cell phenotype during therapy was inversely correlated with HCV viral load. Conclusions: PEG-IFNa activates NK cells possibly contributing to virological responses independently of RBV. The role of NK cells during future IFN-free combination therapies including RBV remains to be determined.


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Jan. 31, 2006
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ALBUQUERQUE, N.M. - In a match-up of top-20 teams the No. 16 University of New Mexico will travel to Provo, Utah, to take on the No. 19 BYU Cougars on Thursday night. The Lobos are 16-4 overall and 6-1 in second in the MWC, while the Cougars are 17-1 on the season and 7-0 in first in the conference. The game will be televised nationally on College Sports Television (CSTV) as part of a MWC doubleheader, with tip-off time from the Marriott Center scheduled for 7:00 p.m. (MST). The game can also be heard locally on KNML 610 AM.
TONIGHT'S GAME: Tonight's game features the No. 17/18 Lobos of the University of New Mexico as they travel to Provo, Utah, to take on the Cougars of BYU in a Mountain West Conference road game. Tonight's game features the two top teams in the MWC and two teams ranked in the top-20.
SCOUTING THE LOBOS: UNM is 16-4 on the season and 6-1 in conference with wins over Oral Roberts in the first round of the preseason WNIT, Cal in the second round, at No. 12 Texas, Marist, Oklahoma State, No. 10 Minnesota, Louisiana Monroe, North Dakota State, home and away against New Mexico State, No. 22 Utah 59-42, at Colorado State 73-57, Wyoming 62-39, at Air Force, San Diego State and UNLV, with losses to Oklahoma twice, at No. 12 Arizona State and at TCU. New Mexico is led in scoring by sophomore Dionne Marsh at 15.9 ppg. Senior Abbie Letz leads the team in rebounding at 7.7 rpg., while junior Katie Montgomery leads UNM in assists at 3.7 apg.
SCOUTING THE COUGARS: BYU is currently 17-1 overall and 7-0 in the MWC with wins at Cal State Northridge, at UCLA, Cal-Santa Barbara, at Stony Brook, at Seton Hall, at UC Riverside, Northern Arizona, Utah Valley State, at Weber State, Portland, Air Force, at Utah, UNLV, at Wyoming, SDSU, at TCU and Colorado State, with their lone loss coming to North Carolina State. The leading scorer and rebounder for the Cougars is Ambrosia Anderson at 19.4 ppg. and 7.9 rpg. Leading them in assists is Melinda Johnsen at 3.7 apg.


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List price $15.61
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- Publisher: Simon & Schuster Childrens Books
- Format: Hardback | 432 pages
- Dimensions: 144mm x 221mm x 36mm | 499g
- Publication date: 14 October 2010
- Publication City/Country: London
- Sales rank: 10,237
Product description
Nora should know better than to think her life can return to normal after falling in love with a fallen angel. And Nora's life isn't normal - her dad was murdered, and the facts about his death just don't add up. Now Nora's own life is in imminent danger. Are she and Patch strong enough for the battle ahead?
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Customer reviews
By Naomi Impellizzeri 20 Jul 2011
I thought this was even worse than the first one, the characters have no morals and I find myself all of them and their relationships, this was just stupid
By Melissa Rogers 29 May 2011
I agree with Lydia's review - Nora is annoying!! AND what sort of a name is Patch far out! I read these types of books because I enjoy the tormented love story and the ups and downs and escapism they present but this 2nd book was just annoying!
In saying I have to concede defeat in that I will most def end up reading the next one in the hope that the series gets better and we see some real patch (ugh) and Nora action.
By Joy Chuah Xin Yee 11 Dec 2010
Wow. Blood pumping, adrenaline rushing and mind reeling. Oh, angst. Yes, definitely lots of angst and frustration. It has everything. The whole story was shrouded in mystery and it makes you think "Is he really the one?".
Urgh, just when I was finally savoring the delicious make up scene of Patch and Nora, the plot twisted and ended at a cliffhanger. A MAJOR and INFURIATING cliffhanger. I read the last chapter so many times until I think I can tell what comes first.
Dammit, Fitzpatrick is good. Bloody good.
By Lydia Presley 16 Sep 2010
I'm in that minority that really was not all that impressed by Hush, Hush. I remember feeling giddy with glee when I saw it was in at the library and rushing home to read it. It was lunch time and I spread the book out on the table and dove in, hungrily devouring every word.
... but then I started to get disappointed. Why? I didn't like Nora. (And don't even get me started on Patch's name).
Time has passed. My feelings of dislike have faded somewhat and Hush, Hush has risen a little bit to a more "okay" place on my list. I lingers there with a few other books that are quite popular and it hovers over some others that I really could not stand.
Crescendo was like a slap in the face. Not only was my dislike of Nora brought back.. but now she's displaying angst and emo-teenage-heartbreak worthy over only the queen of such herself, Bella Swan. The only reason this book rates as high as I've given it is because the rest of the plot (such as it was) was interesting and I liked seeing the bad boys get the spotlight here. But Nora? My goodness, someone needs to slap that girl.
There is probably a 5% chance I'll read the final book. Even the cliffhanger wasn't enough to get me to be interested in reading it. But... who knows, maybe I'll read some truly horrendous YA books between now and then and Crescendo, like Hush, Hush will slowly raise in status as time passes by.


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Daisette Youth participate in workshop, decoration day
Members of the Daisette Youth Garden Club held their monthly meeting Feb. 21.
Nyasia Miller, club president, read a passage from a book by Helen Steiner Rice, "Loving Promises," entitled "Your Problems! My Problems! Our Problems!" For the devotion, the group recited "A Garden Club Prayer." Miller then conducted the business meeting, followed by group members each listing their recent grades and scholastic achievements.
Vivian Bullock, the group's advisor, conducted a "Making Valentines" workshop with members in attendance. Members used construction paper of various colors for cutting out valentines. They were distributed to locals who were shut in or sick.
Following the recital of the Youth Pledge, the group adjourned the meeting.
Back on Feb. 2, Bullock, as well as Barbara Carroll conducted another workshop for club members, along with members of the Shiloh Baptist Church of Henderson's Youth Missionary Department and adult leaders, at the Henderson Institute Historical Museum. They made decorations using soap, washcloth, silk flowers, felt and ceramic tile. Edna Scott, museum curator, gave the group a tour and presented to them a brief history of the facility.


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