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Building the Tools that Fight Type 1 Diabetes
Dr. Ding's cellular-reprogramming methods are already revolutionizing the fields of science and medicine.
Dr. Ding's work builds on the cell-reprogramming work of Gladstone Investigator
In today's study, Dr. Ding focuses on reprogramming skin cells into β-cells using existing iPS cell technology—but with a twist. Using a unique chemical cocktail of small molecules and other reprogramming factors, Dr. Ding never lets the cells enter the pluripotent state. Avoiding the pluripotent state is important because it avoids the potential danger that 'rogue' iPS cells could develop into a tumor if used to replace or repair damaged organs or tissue. This method also makes it possible to create a far greater number of cells for research or regenerative purposes.
Type 1 diabetes, which usually manifests during childhood, is caused by the destruction of beta-cells (β-cells). β-cells are a type of cell that normally resides in the pancreas and produces a hormone called insulin. Without insulin, the body's organs have difficulty absorbing sugars, such as glucose, from the blood. Once a death sentence, the disease can now be managed with regular glucose monitoring and insulin injections. A more permanent solution, however, would be to replace the missing β-cells. But these cells are hard to come by, so researchers have looked towards stem cell technology as a way to make them.
"The power of regenerative medicine is that it can potentially provide an unlimited source of functional, insulin-producing β-cells that can then be transplanted into the patient," said Dr. Ding. "But previous attempts to produce large quantities of healthy β-cells—and to develop a workable delivery system—have not been entirely successful. So we took a somewhat different approach."
One of the major challenges to generating large quantities of β-cells is that these cells have limited regenerative ability; once they mature it's difficult to make more. So the team decided to go one step backwards in the life cycle of the cell.
The team first collected skin cells, called fibroblasts, from laboratory mice. Then, by treating the fibroblasts with a unique 'cocktail' of molecules and reprogramming factors, they transformed the cells into endoderm-like cells. Endoderm cells are a type of cell found in the early embryo, and which eventually mature into the body's major organs—including the pancreas, the home of β-cells.
"Using another chemical cocktail, we then transformed these endoderm-like cells into cells that mimicked early pancreas-like cells, which we called PPLC's," said Gladstone Postdoctoral Scholar Ke Li, PhD, the paper's lead author. "Our initial goal was to see whether we could coax these PPLC's to mature into cells that, like β-cells, respond to the correct chemical signals and—most importantly—secrete insulin. And our initial experiments, performed in a petri dish, revealed that they did."
The research team then wanted to see whether the same would occur in live animal models. So they transplanted PPLC's into mice modified to have hyperglycemia (high glucose levels), a key indicator of diabetes.
"Importantly, just one week post-transplant, the animals' glucose levels started to decrease, and gradually approached normal levels," continued Dr. Li. "And when we removed the transplanted cells, we saw an immediate glucose spike, revealing a direct link between the transplantation of the PPLC's and reduced hyperglycemia."
But it was when the team tested the mice eight weeks post-transplant that they saw more dramatic changes: the PPLC's had given rise to functional, insulin-secreting β-cells.
"These results not only highlight the power of small molecules in cellular reprogramming, and are proof-of-principle that could one day be used as a personalized therapeutic approach in patients," explained Dr. Ding.
"I am particularly excited about the prospect of translating these findings to the human system," said Matthias Hebrok, PhD, the Hurlbut-Johnson Distinguished Professor of Diabetes Research, who is one of the study's authors and director of the UCSF Diabetes Center. "Most immediately, this technology in human cells could significantly advance our understanding of how inherent defects in β-cells result in diabetes, bringing us notably closer to a much-needed cure."
* * *
Saiyong Zhu, PhD, Shaohua Xu, PhD, Tao Xu, PhD, Yu Zhang, PhD, and Tianhua Ma, PhD also participated in this research at Gladstone, which was supported by the Roddenberry Foundation, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Energy Institute, the National Heart, Lung and Blood Institute, the National Institute of Mental Health/National Institutes of Health, the California Institute for Regenerative Medicine, the United States Department of Defense and the William K. Bowes, Jr. Foundation.


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Portland, Oregon native Matt Lyons is a full-time student and professional cyclist in Denver, Colorado. Recently, Matt won the individual omnium at the USA Cycling Collegiate Road Bike Championships in Ogden, Utah, and he won the cross country short track at the 2011 USA Mountain Bike Nationals.
Matt's Top 5:
- My 40 oz Wide Mouth green Hydro Flask for all day hydration whether with cold water or hot cocoa
- My bicycle
- Colorado mountain climbs
- Sunny weather
- My headphones
Career Hightlights:
- 2011 Collegiate Mountainbike Short Track National Champion
- 2013 2nd in the Collegiate Criterium National Championships
- 2013 Collegiate Individual Road Omnium National Champion
- 2013 17th at the U23 National Championship Road Race
- 2013 18th at the U23 National Championship Time Trial
- 2013 Signed first professional contract with Airgas Cycling Team

subset: commoncrawl


text:
To the rescue!
It's "Dynamic Duets" night on "Glee" as the New Directions join the superhero club with Blaine and learn the Warblers have taken their coveted Nationals trophy. Watch what's to come in tonight's episode.
Lenny Kravitz as Marvin Gaye? Get the details in Soaps.com's Celebrity News. Take a look at Thanksgiving in the Hamptons in Soap Opera Fan's Revenge Spoiler Video.
Join us on Twitter @soapoperafan, and Facebook. Come tweet and Facebook with us about all soap operas, "Glee," "Grey's Anatomy," "Vampire Diaries" and "Venice the Series."
Header photo credit: FOX
- Lori Wilson


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967 Reviews)(
Release date : tuesday 12 joly 2011 02:30
Publisher : Simone Odoardi
Version : 220.127.116.11
Size : 12.5 Mo
Languages : English
What is GravBowl ?
Have you ever played bowling vertically?
Now you can do it, thanks to your Windows Phone 7 and to Gravity Bowling, or GravBowl as we call it among friends.
Twenty challenging and amusing tracks are waiting for you.
Direct the ball by moving your mobile phone and try to put down as many pins as possible.
Bonus, obstacles and penalties add a little spice to the experience.
Will you achieve the perfect game?


text:
Train Derailment South of Plaster Rock leads to evacuation of 150 people
A train derailment just south of Plaster Rock iss the latest in a string of train accidents and it's getting national attention. Fortunately no one was injured; but about 150 people were evacuated from their homes. News Source 8's Angela Christoforos reports…
Andrew Simpson who was evacuated from his home said, "We were right there when it happened, so we just looked out the window and seen everything.
" What did it look like?"
"Just a big orange glow."
That big orange glow was the result of a fiery train derailment just South of Plaster Rock in Wapske around 7 o'clock Tuesday night. While some reports point to a faulty break system, CN Rails President and CEO said at Wednesday's press conference it's still too soon to say for sure.
CN President and CEO Claude Mongeau said, "It's a bit early to assess cause at the moment we're focused on containing the site and dealing with the fire."
The freight train hauling crude oil and propane had 122 cars on it; 17 of which were derailed.
New Brunswick Premier David Alward said, "I'm thankful that there's been no one hurt, I'm very thankful as well that it appears that the impact on the environment is minimal."
According to the Canadian National Railway, the freight train was headed to Moncton from Central Canada when it ran off the trails of the track. As a safety precaution, 150 people were evacuated from their homes.
"Our first priority is to actually is to get them back home as soon as possible. If there are consequences from this instance CN will step up and compensate residents," said Mongeau.
In the meantime the Canadian Red Cross is providing aid and shelter is available to evacuees at the Tobique Plex community center in Plaster Rock.
Lyla Bear-tatloca who was evacuated from home said, "Where I live you can hear the train going by all the time.. I'm surprised."
Residents are being urged to steer clear of the impacted area for their safety until further notice. As of earlier this afternoon crews were still on the scene containing the fire. According to the New Brunswick Premier and President of CN Rail, overall response to the incident was handled well and in a timely fashion.
Category: News


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Posted: October 23, 2013|
THREE of west Cornwall's finest farms have claimed top prizes at a national cattle contest, with one herd heralded the finest in the land.
The overall winner of the Devon Cattle Breeders' Society's competition was St Just's Bollowal herd, owned by Jeff and Pat Thomas.
Also claiming the coveted best stock bull of the year award for their animal Jack of all Trades, the couple were elated.
Mr Thomas said: "We're very proud because it was the national competition – to win that was pretty special.
"We have got the best cows in the country – of the ones that entered. We're very pleased."
Mr Thomas opened the doors to his farm last Friday and said visitors from as far as Northumberland and Cumbria came to have a look at the winners.
It was not the first time the farmer's herd has come up trumps at a farming showdown. According to the society, the Thomas' livestock has been consistently up there with the best on the breeding circuit for many years.
West Penwith was further honoured by judges on the day, with two other farms given awards – one of which was Steve and Bridgette Clamp's, who own Higher Trenowin in Nancledra, close to Penzance.
The pair, who had never entered before, claimed best cross-bred calves for their Red Ruby Devon and limousine cows breed.
"It's great for us – we're quite new to the breed," said Mr Clamp. "We've been breeding for only a few years. It was our first time entering the competition, we didn't expect to win. We just want to the experience and to get comments from judges.
"We've put in a lot of work and effort. We're constantly trying to improve."
The Clamps also saw their pedigrees come second in the medium-sized herd category - out of over 400 entrants across the UK.
The west Cornish trio was rounded off by the Hoskings, who have farmed in St Buryan for many years. The family took awards for best cow, given to Yeomadon Sally 2nd, and for the finest small herd.


text: The WFHB Unusual Suspects Radio Acting Troupe is pleased to announce that two of our more popular characters from shows past–Penelope Pringle, vascular recovery nurse, and Oprah Operagurl, the only opera singer in the world to accompany herself on the violin–have time in their busy schedules to join us for "Forbidden Vegetables," the winter edition of the Firehouse Follies.Plus, special musical guests Harpeth Rising. Join us at 4 p.m. Dec. 14 at the Ivy Tech Waldron Whikehart Morris Auditorium to see what they're up to. You'll be glad you did!


text:
About AQ
About Aquinas
About Grand Rapids
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Field placements provide invaluable experience for the student and they also provide the Aquinas College School of Education with professional assessments of the student performance in the field. Recommendations for certification are based not only on academic and classroom performance but also on successful work in field placements. This includes, but is not limited to, professional attitudes and actions with cooperating teachers, supervisors and students encountered in pre-k thru grade 12 classroom settings. All improprieties will be documented in a "Concern Form" and some improprieties may result in immediate dismissal from the education program. All assessments are taken into consideration when a recommendation for teacher certification is to be made.
Many, if not most, of the education classes are offered in the evening but will require a "DAYTIME" field placement (field component.) It is the intent of the Aquinas College School of Education to give students a global perspective of education systems. Students will have experiences in a variety of settings; public, private, urban, suburban and rural school districts. The School of Education has a placement policy denying placements in a school setting where the student has formerly attended or is either employed, has a spouse or other family member employed, or where their children attend.
Additionally, students should not expect to be placed in the same school for their Directed Student Teaching placement where they have completed their EN 201 Introduction to Education .
Please Note: Students should keep a record of all field placements as they progress through the certification program. Special notation should be made of the course number, the placement (school and district), cooperating teacher, the grade and subject area. This information will be requested on the Directed Student Teaching Pre-Application and should be documented in the
AQ SOE Portfolio
Placement Purpose:
The purpose of field placements in the EN201 program is to give the Introduction to Education student an opportunity to observe and experience teaching in the real life context of today's classrooms with the guidance of a cooperating in-service teacher and the benefit of feedback from an experienced external observer. This is an opportunity for you to experience the classroom as a teacher and decide if this is what you would like to further pursue as a profession. It provides us with an opportunity to see you work with children and provide guidance for your future preparation to attain a teaching certificate.
Placement Procedure:
The Director of Field Placement arranges ALL placements. Whenever possible, placements are set up to accommodate the student's requests in terms of location (see below), days and times, grade level, and content area preferences. Suggestions by the student for a specific placement will be considered as long as it does not violate the stated requirements and limitations for placements in this program. Do not contact teachers or principals to arrange your own placement. This will result in an automatic cancellation of that placement. This is done formally through the Aquinas College School of Education.
Students will be notified of their placement by phone and/or in writing and you are required to call the contact person indicated to establish exactly when to arrive at the placement. No placements will be made until the student has submitted all of the required paper work: a Pre-Placement Information form, a Student Information for Cooperating Teachers form, a Student Criminal Record Information form, and documented negative TB test results. Placements are typically made within the first four weeks of the beginning of the semester.
Placement Policies:
Field Supervisors:
Experienced field supervisors will be assigned for each student's placement in EN 201. Field supervisors are required to visit the student at least four times during the length of the placement and observe the student actively working in the class for an average of 30 to 45 minutes. It is expected that the field supervisors will give feedback to the students as soon as possible and turn in a written account of the observation to the Director after the debriefing.
See the "Student Teaching" web page for detailed information on procedures and requirements pertaining to this important field placement.


text:
This page is an index of ACHA and other resources on this topic. Resources include association projects, programs, publications, guidelines, and more. Additional information may be available under "External Resources."
ACHA Resources
Coalition of Allies for LGBT Health
Provides multidisciplinary, multiregional education, advocacy, and research on on issues relating to LGBT health
10 Ways to Make Your Health Center More Welcoming for Diverse Students [pdf]
ACHA Brochures for Young Adults
Man to Man
Woman to Woman
ACHA-National College Health Assessment
The ACHA-NCHA is a nationally recognized research survey that provides precise data about students' health habits, behaviors, and perceptions. Data from this survey covers smoking habits, contraception use, mental health issues, relationship difficulties, sexual behaviors, exercise habits, preventive health practices, perceptions of drug and alcohol use, and more.
External Resources
ACHA thanks its committee, coalition, task force, and section volunteers for providing resources and links concerning this topic. ACHA does not endorse or accept responsibility for the content or use of external websites.
The College Health LGBT Listserv
Creating Safe Space for GLBTQ Youth: A Toolkit from Advocates for Youth
Cultural Competency and Diversity Websites [pdf]
Gay and Lesbian Medical Association (GLMA)
ACHA Liaisons to GLMA:
Sharon Glezen, MD
University of Rochester
Shirley Dinkel, APRN
Washburn University
GLMA Listserv for the LGBT Nursing Community
The Gay, Lesbian, Bisexual, and Transgender Health Access Project
Gay Men of African Descent (GMAD)
Healthy Lesbian, Gay, and Bisexual Students Project – from the American Psychological Association and funded by the Division of Adolescent and School Health of the Centers for Disease Control and Prevention (CDC-DASH)
The Mautner Project (The National Lesbian Health Organization)
National Consortium of Directors of LGBT Resources in Higher Education
Youth Resource – a website that explores issues of concern to GLBTQ youth and provides information and offers support on sexual and reproductive health issues through education and advocacy


text:
|Knights Inn Atlantic City properties are provided below. Search for cheap and discount Knights Inn hotel rooms in Atlantic City, NJ for your upcoming meeting or individual travels. We list the best Knights Inn Atlantic City venues so you can review the Atlantic City Knights Inn hotel list below to find the perfect place.
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text:
|Matthew Dillon <dillon@xxxxxxxxxxxxxxxxxxxx>
|Fri, 18 Jul 2003 21:01:59 -0700 (PDT)
:How does this relate to schemes (to which I've become increasingly fond :of, the more I think about it) where packages install entirely in :self-contained filesystems? i.e., such that /usr/packages/bin becomes a :sort of stack of dozens or hundreds of packagefs's, and removing a :package becomes as easy as deleting /usr/packages/backing/pkg-2.3 (the :moral equivalent of a vn(4) backing file)? : :I'm not quite clear from reading the docs whether this is actually what :you mean, or a complementary scheme, or what. : :-- :Matthew Fuller (MF4839) | fullermd@xxxxxxxxxxxxxxx I don't consider such schemes as solving the correct problem. The *real* problem with multiple package installation are all the third party libraries packages depend on. I do not want to duplicate 30 third party libraries 30 times for 30 interdependant packages, so there needs to be a way to share compatible third party libraries. The way I want to do that is by explicit versioning which is entirely OUTSIDE the package's control, which I would accomplish by creating an environmental overlay for the package which makes the exact versions of the libraries it is supposed to be using available to it and hides everything else from it. -Matt


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Ontario Student Transcript, Ontario Student Record and Full Disclosure
The Ontario Student Transcript (O.S.T.) is a provincially standardized document which is the student's official record of credits earned. Copies are available to students on request.
The O.S.T. is kept in the student's Ontario Student Record folder (O.S.R.). This folder contains achievement results, credits earned, and other information important to the education of the student. The O.S.R. is created when a student enters the Ontario school system, and moves with the student from school to school. The O.S.R. is created under the authority of the Education Act, and the contents of the O.S.R. are protected under the Freedom of Information and Protection of Privacy Act. Students and their parents (if the student is not an adult) may examine the contents of the O.S.R.
Full Disclosure: Since September 1999, the Ontario Student Transcript reveals all Grade 11, and 12 courses attempted including those failed, dropped or repeated. This change to the transcript allows a more valid evaluation of each student's academic performance. Students must be careful to meet the deadline (one week after distribution of mid term reports) to drop a course from their timetable. Failure to meet this deadline could result in a course remaining on the Ontario Student Transcript and thus part of the student's permanent record - Ontario Student Record (O.S.R.).
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If Neils Miller doesn't have a statue in Appleton, Wisconsin, he should. You'll be hard pressed to find someone who has had a larger impact on the welding industry than Mr. Miller. Back in 1929, he saw a need for a small, affordable arc welder that would operate on the type of electricity readily available in rural Wisconsin. Using American ingenuity, he cobbled together scrap metal, core and coil materials and hammered out that first welder in his basement. Six short years later, Miller Electric Mfg. Co. produced an industry-changing industrial welder and the rest is history.
Throughout the 40's, Miller's machines powered war efforts in the shipyards and defense plants. In the 50's, Miller played a key role in the construction of most major planes, jets, fighters and missiles. Companies like Boeing, Cessna, Lockheed, Douglas all used Miller machines in their factories. The 1970's brought the introduction of the Millermatic machines; the first power source with a built-in wire feeder.
Today, Miller Electric continues their dominance in the marketplace with machines like the Millermatic 211 and the Dynasty 200 DX, Auto-darkening welding helmets, and the Diversion 180 AC/DC TIG Welder. Miller's full line of welding machines and welding accessories give their loyal customers plenty of reasons to "Bleed Blue."


text:
...before your first one is out the door?
inXile Entertainment, Inc.; the people already working on the wildly over funded Wasteland 2 have decided to start a second kickstarter project before even delivering on their first.
Seems really shady and do these guys have any legitimate claim to Planescape: Torment other than working on similar games in the past?
I can see funding for this taking off in a big way, it's already up to $190,000 and it's been active for less than an hour.


text:
Pygmyfoto, a DIY photo publishing solution
Photo Rolling
Photo publishing applications are scarce, so we show you how to build one.
WordPress is an excellent photo blogging platform, but what if you don't need all the bells and whistles it has to offer? Surprisingly, decent no-frills photo blogging applications are few and far between. With no viable alternatives around, the only recourse is to build a simple photo publishing application from scratch.
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Qemu Flaw Lets the Guest Escape
Xen project announces a privilege escalation problem for Qemu host systems
Android Bug Threatens Millions of Users
Attackers can compromise an Android phone just by sending a text message
Lenovo and Canonical Announce Laptop Deal
PC vendor will pre-install Ubuntu on portables in India.
Mozilla Firefox Blocks Flash
More embarrassment for Adobe's embattled multimedia tool
Security Problem in Firefox's NoScript Add-On
Mozilla's script blocker add-on could be putting malware sites on the whitelist.
RIP SSLv3
The Internet community officially banishes the notoriously unsafe Secure Sockets Layer protocol.
Mate 1.1 Arrives
Popular desktop environment continues the Gnome 2 legacy – with new support for the Gnome 3 toolkit.
US Government Requires HTTPS
The Obama White House has issued a memorandum telling all US government agencies they must use HTTPS for all websites and web communication.
Mozilla Signs Firefox Add-Ons
New program will dial up security for the Firefox browser.
Fedora 22 Arrives
Red Hat's community distro embraces the cloud.


text:
Hang tight!
Recipe by Laurie VanKlaveren
"My mother, Georgia, always made this cheese ball during Thanksgiving and Christmas. It wasn't the holidays until the cheese ball was out! It's easy and very good. Serve with Buttercrisp crackers or torn pieces of French bread."
Hmm. None of these ingredients are on sale today.
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1 (8 ounce) package
cream cheese, softened
1/4 cup
dried minced onion
2 tablespoons
Worcestershire sauce
1 (8 ounce) can
mushroom stems and pieces, drained and chopped
1/4 cup
chopped fresh parsley
I thought this was a little to bland for my taste buds, sorry.......I did a little changing by adding in a few extra ingredients to go with my taste. I added in garlic (thats a must for me) about 4 cloves very finely chopped, chives and about 1/4cup chopped walnut mixed everything in and shapped it into a ball. Its even better the day after.
I liked it... not sure what you all are talking about, but my family said it was really good. I made it and then let it sit overnight. I think that's why yours was "bland"- you need to let the flavors set for awhile. Also, if you eat it when it's cold, it won't have as much flavor as if it's room temp.
3 Ratings
Very bland
* Percent Daily Values are based on a 2,000 calorie diet.
Georgia's Famous Holiday Cheese Ball
Serving Size: 1/15 of a recipe
Servings Per Recipe: 15
Amount Per Serving
Calories: 61
Calories from Fat: 47
With our 2,700+ chicken breast recipes, you'll never serve the same old chicken again.
The firm, juicy texture of zucchini make them a perfect side to toss on the grill.
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See how to make a pecan-studded cheese ball with Cheddar and cream cheese.
See how to make a holiday cheese ball that looks like a pine cone.
It's like a chocolate cheesecake without all the hard work!


text:
Part of the 'Visual Lease in 30 Minutes' Webinar Series
May 28, 2014 at 2:00pm EDT
As real estate professionals, we continually evaluate how efficiently and effectively Lease Occupancy Costs and other key expenses are monitored. We'd like to invite you to join us to see how easily this can be achieved.
Visual Lease is a cutting-edge, easy-to-use web-based lease management system that empowers you with real-time, actionable information through an extraordinary user experience. Please join our webinar to discover how Visual Lease helps eliminate the need for monthly journal entries and gives you tighter control over your real estate expenses. We will show you how to eliminate duplication of financial data entry, use Straight Line Rent to report on a GAAP basis, and integrate our Accounting Feed to output your real estate expense data directly into your accounting system.
This 30-minute webinar will cover:
- Financials – Default Account Settings and Features
- Straight Line Rent
- Accounting Feed Set-up
- Accounting Feed Reporting
After registering, you will receive a confirmation email containing information about accessing the webinar. We hope you can join us!


text:
AUSTIN, Texas (AP) - The Texas Longhorns are in crisis.
The defense is in shambles, coach Mack Brown is facing rampant speculation that his job is on the line and a season that started with the promise of a rebirth of Longhorns football is teetering on the brink of collapse just two games into the season.
And here come the No. 25 Ole Miss Rebels (2-0), ranked for the first time in four years and eager to shove the Longhorns (1-1) off the cliff Saturday night.
Brown fired defensive coordinator Manny Diaz within hours after an embarrassing loss at BYU last week and hired Greg Robinson, who was the Longhorns defensive coordinator in 2004.
Brown needs Robinson to fix his defense in a hurry. But by midweek he tried to lower expectations as Robinson had only a few days to prepare. Brown noted the Longhorns' Big 12 schedule doesn't start until the next game.
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I bought a 95 legacy three years ago when gas went to $4.25. I was driving a pickup . At $125 a week just for work it was time to change. I paid $1300 for it . It wasn't shinny but was a NJ car. It had 245,000 on it.
It cut gas in half at nearly 35 mpg on two lane highways. It took me all over the Catskills and Adirondacks. With little maints. it kept going. Last year we had 15 inches of snow. My street wasnt plowed. I shoveled out to the road. Backed out and plowed
a couple hundred yards to the main road. Today it has 305,000 miles on it and fighting for every mile. I working on getting a 94 with 160,000 miles from southern PA. I've owned many cars and trucks over 35 years and this is by far the best of any of them. I hope the 94 runs a well.
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text:
Light Flight
A reader blog about flying ultralights with Robert Laird
Monthly Archive for October, 2011
Fly for free
Imagine stepping into a small aircraft, closing the canopy, rolling down the runway, ascending into the clear blue sky, flying for 270 miles and landing, and all of that didn't use up one single drop of gasoline, diesel or other chemical fuel? Sound like a future scenario? Maybe this will happen in 30 years? Nope, […] [Read More]


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Thanks for the comments. We plan to follow this story and have an update on how the testing in Florida goes for Michael and the "Tampa 24."
Thanks for reading, Adam Bouton
@David Farley
Thanks for the comment. It was neat to see the young men get excited about receiving ties and then learning how to tie them. It's definitely a cool thing to do close to the end of the school year. Thanks for reading.
Adam Bouton
Here's an update on the story including reaction from several board members and what the township plans to do next: http://www.mlive.com/news/saginaw/index.ssf/2012/05/buena_vista_township_board_mem.html
We'll have more on the story as it continues to develop.
Thanks for reading and commenting. She declined to say where she was headed.
MLive readers, how are you celebrating Cinco de Mayo today?
MLive readers, what Cinco de Mayo activity are you most excited about tomorrow?
Check back MLive.com/saginaw tomorrow morning for a release of some of the plans and artist renderings of the new Buena Vista Town Center site.
Thanks for the comments, everyone.
Thanks so much for the comment! I wish Drew all of the best in the future.
@GoBridgeport, thanks for catching my mistake. It's been fixed.
Hey @Jaded Eyes
Thanks for the comment. He was a neat kid to talk to, very sure of himself. There's no doubt in my mind he'll go on to do great things, in the military and beyond.
Who is ready for the weather change? Personally, I'm ready to ditch my coat.
Is anyone planning on running this weekend?
Readers, are you planning on attending the festival this year? What parts of the festival do you enjoy the most?
The manager of Mr. Hot Dog, Mark Glysz said that there were three in Bay City at one point and 10 or 11 total throughout Michigan, including some in other tri-city cities. I'm not exactly sure, however, when Mr. Hot Dog was started or where the original store was. Thanks for the interest.
Adam Bouton
Mr. Hot Dog made an impromptu appearance yesterday in MLive's best coney dog competition.
Here's our coverage: http://www.mlive.com/entertainment/bay-city/index.ssf/2012/04/by_popular_demand_mlive_coney.html
Thanks, everyone for joining the discussion. There doesn't seem to be a shortage of popular coney dog places in Saginaw or Bay City.
Thanks for joining the discussion, everyone. Hopefully the last Mr. Hot Dog remains open so that current and former Bay City residents can return to take a trip down memory lane and enjoy some good, cheap coney dogs and other treats.
Readers, is the A&W Drive-In a spot that you frequent often? Is it your favorite summertime restaurant in Bay City? Let us know what you think.


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Think of it as Christmas lights from the heavens — or an omen of Mayan doom.
Viewing tips
As with any celestial display, the darker the better; move away from lights. The beach is better than downtown, astronomer Terry Richardson suggests.No point in facing any one direction; Geminid shooting stars can come from anywhere in the sky.If out at 2 a.m., lie down. The best show will be directly overhead.If shooting digital photographsSet the exposure to 1 minute if possible, but at least 30 seconds, and keep extra batteries at hand.Use as wide an angle as possible, and set the lens wide open.
But you might want to step outside tonight to watch the Geminid meteor shower.
Watch online
Can't make it outside? To watch the Geminid shower online:Go to fireballs.ndc.nasa.gov for captured images from the night before.Go to nasa.gov/connect/chat/geminids2012.html to ask questions of experts and watch live telescope and camera feeds from the Marshall Space Flight Center in Hunstville, Ala.
Dozens, if not hundreds, of shooting stars per hour will dart across the sky from any direction. Clear skies are expected, and because this year there's a new moon, the skies will be darker than usual for the annual show.
"People are expecting (to see) a meteor a minute, maybe more," said Terry Richardson, a College of Charleston astronomy professor.
The show will peak in intensity about 2 a.m. Friday, when the Gemini constellation is directly overhead. But meteorites will begin to blaze at 9 p.m. or earlier, soon enough for the kids to get a look. The shower Friday night into Saturday morning should be just about as good.
Year to year, the Geminid meteorites put on probably the best show of the annual showers, Richardson said. Among other attractions, Geminid shooting stars tend to streak relatively slower.
The Geminid are also a bit of a mystery when it comes to meteor showers, most of which come from rocky bits and pieces spewed by an icy comet passing by. Not the Geminids.
They appear to come from 3200 Phaethon, which NASA Science describes as "a weird rocky object" in space.
Phaethon is likely an asteroid, essentially an orbiting rock that's bigger than a comet, almost a miniature planet.
Some researchers now propose that Phaethon is what they call a rock comet, an asteroid that passes so close to the sun that its gravel-like debris gets scorched off.
The bottom line: Nobody knows.
"This one appears to be an asteroid," Richardson said. "But it may be a burned-out comet."
Reach Bo Petersen at 937-5744, @bopete on Twitter or Bo Petersen Reporting on Facebook.
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Welcome to Saint John! We, The Catholic Family of St. John the Baptist, located in Fayetteville, Texas is a community that shares in the fellowship of Christ. We are rich in our German/Czech heritage, instilled with the work ethic and devotion to God of our ancestors. We come together to offer the liturgy of praise, proclaim the Good News and be a witness and sign of God's Kingdom on earth.
Our Mission:
Through our Baptism and the celebration of the Eucharist, we will:
- Provide an environment of faith, hope and love.
- Recognize the work and dignity of all people and defend the sancticity of human life.
- Continue Christ's mission of love and justice in our homes, in our parish and community and throughout the world.
- Educate our children in respect, responsibility and reverence through the teachings of our Catholic tradition.
- Use our time, talent and treasures in a spirit of generosity and compassion for those less fortunate than ourselves.
Register with our parish family by completing the Parish Registration and forwarding it to the parish office.


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Lecture: "Fiamma Montezemolo: Borderline Ethnography"
Mon, February 17, 2014 • 12:00 PM - 1:00 PM • SAC 5.118
Artist and anthropologist Fiamma Montezemolo will reflect on the trans-disciplinary and trans-methodological aspects of her work on the U.S.-Mexico border. She will discuss how her work straddles various registers of the 'border' concept and the multiple forms this work has taken over the years. Montezemolo frames the border in geopolitical terms with a particular emphasis on her fieldwork experience between Tijuana and San Diego; in cultural and metaphorical terms with a specific focus on the different modes of representation in, alongside, and beyond the geopolitical border; in assemblage and montage terms as an interplay of visual and discursive strategies in order to make sense of Tijuana, a city that has been hailed as the laboratory of post-modernity; in aesthetic and formal terms through her academic writing, experimental ethnographies, and video-installations at the threshold between art and anthropology; and finally, in affective terms that explore the potentialities and the limits of the border as a complex structure of feeling.
For more information on this and other events featuring Fiamma Montezemolo, visit Intermedia Workshop.


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5 Reasons to Choose Hand Made Decor
Guest post from the talented interior designer Penelope Sloan. What is it about hand made items? They always seem to catch my eye in a way mass produced items don't. They emit a certain charm, perhaps due to their unique … Continue reading
Cost or Investment Part 2
Recently, I wrote a post on investing in new furniture from the eyes of a consumer. I have a few ideas on what furniture with good bones should look like and thought I'd share. Here is the continuation of that … Continue reading
East Vancouver Culture Crawl
The East Side Culture Crawl is an anticipated annual 4-day art and craft viewing adventure. Over 300 East Vancouver artists, designers, and artisans slide open their doors and grant viewers the full monty! Art and design lovers are exposed to … Continue reading
Cost or Investment?
I met with a friend the other day and we started discussing poorly crafted furniture. She is an upholstery artist and often has clients bring chairs to her shop to change the fabric. Her current project is a brand … Continue reading
Copenhagen- My People
I have been fortunate to travel to many places. I've lived in Europe, North America and Asia and have always enjoyed exploring cultures different than what I'm familiar with. Recently, I had the opportunity to travel to Copenhagen. I learned … Continue reading
Copenhagen Botanical Garden
I am mere hours from arriving back in Vancouver after a week in the "Holy Land," Copenhagen. As a furniture maker and designer, Denmark is a place I have long admired and is a mainspring for my inspiration and innovation. … Continue reading
Furniture care Part 4: Oiling Wood Furniture
What is truly spectacular about quality wood furniture is how the tones of the wood shift with each passing year. What can prevent enjoying this beautiful and natural evolution is the drying out of wood. As mentioned in previous posts … Continue reading
Furniture Care Part 3: How to Wax
Not so long ago, wax was the go-to finish for furniture. As technology developed, so did our options for wood finishes. As more modern finishes became available, wax was replaced due to the limited protection it can offer wood. Today, … Continue reading
Care Part 2- How to Identify the Finish and Why this Matters
When you want to revive dull looking wood, you need to first identify what finish is already on the piece; mixing up finishes can be disastrous . Continue reading


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"A portrait of my children, once a week, every week, in 2013."
Luca: We're into pirates. We make pirate ships out of boxes, we draw them on paper and there's much digging going on in the garden looking for treasuRRRR. Luca and Graeme even built a treasure chest out of leftover wood in the garage last weekend. I realised this week my nifty origami boat-making skill needn't stop at boats; I made someone a pirate hat. It didn't fit, no matter how big a piece of paper I used, so we used yarn to secure. Luckily, Daddy came up with the eyepatch to make sure this person looked like a pirate... and not a nurse. (It was only when I uploaded this photo that we noticed his 'hook' – so in character.)
Kian: A morning walk with Sydney. He played a game of throwing his hands in the air and crashing down on the sand. I'm working hard to keep his layers on. We can't work out whether he doesn't feel the cold or if he's just plain stubborn. I know what the answer is when I sneak into his cold bedroom and see him all tightly curled up, his hands and feet tucked underneath him, his socks and blankets strewn across the floor.
Previous 52 posts
My favourite from the 52 family: I love seeing children climb trees and play in nature – this one of Bella at Little Buckles is truly beautiful.


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Master of Science
(30 Credit Hours)
The curriculum provides a foundation for acquiring important knowledge and leadership skills required for success in the accountancy profession. You'll choose one of three tracks – financial/auditing, taxation and a generalist track – and you'll learn to evaluate critically, think broadly and make ethical business choices. The summer study abroad program provides a unique international experience.
Upon completion of this program, you will have the educational requirements for licensure as a CPA in most states, and be prepared to work in public accounting firms, private industry and government agencies. If you have earned a bachelor's degree in accounting, you can complete the program in ten months and participate in a CPA exam review during the summer following your matriculation.
Admissions Criteria
- Official transcripts from all academic institutions
- Official GMAT score of 530 or higher
- TOEFL scores if your primary language is not English
- Undergraduate GPA of 3.0 or higher with a 3.0 in upper-level accounting/business courses
- Successful completion of specified accounting and business courses
2014-15 Tuition
in-state: $500 per credit hour
out-of-state: $1,304 per credit hour
ConTact Information
Roger Daniels
Program Director


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The Elegance of Wood
BregenzerwaldBregenzerwald on the map
Exploiting its intrinsic beauty is just one reason why so many craftsmen, master builders and architects in Vorarlberg have devoted themselves to this special material with heart and hand. What fascinates them all is that wood from the region is the answer to so many pressing questions in our lives – from sustainable protection of nature to a style of living to delight the senses: wood eases the burden on our environment, and decelerates time. It creates a healthy atmosphere in a room, equalising humidity and not becoming electrostatically charged. It re-grows, can be obtained easily and disposed of without residual waste, and saves energy.
The fact that wood is also durable and still looks great even after centuries has much to do with the care with which it is selected, felled, dried and worked – a care that has been handed down through the ages. Thus roofing tiles are made from water-repellent larch. The weather side of a building is clad in pine and the side facing the sun in spruce, while Swiss pine is just right for terrace floors. When felling the wood, the phases of the moon play are every bit as important as the timing of what is felled when, and for what purpose. Wood acquired in winter, out of the growing season, is a naturally long-lasting wood for construction; by contrast, wood felled in summer when the moon is waxing is suitable for pile constructions in water, such as wooden jetties or boathouses. It may sound like a country saying, but it is wisdom confirmed empirically over centuries and now backed up by laboratory tests.
Take a 'culture of wood' walk in Hittisau, and you can track the roots of the craftsman's skill in handling this forward-looking material with its promise of a better world: the arc spans from a visit to a Bregenzerwald farmhouse to crossing the oldest covered wooden bridge in Vorarlberg, before leading on to a modernised inn and the newly-built 'Feuerwehr- und Kulturhaus', serving both as the fire station and the building housing the Hittisau Museum of Women. Wood plays the main role in all these constructions: it is sleek, elegant, spectacular. And it smells great!
It can be experienced close enough to touch at the wood workshop run by Markus Faißt, who devotes love, commitment, serious application and immense skill to making furniture for the good life – from Zurich to Athens, from Washington to Vienna. Dining, living, working, sleeping – these are the things he focuses on; for instance, he has designed a bed that does away entirely with metal and glue. The individual parts are connected using dovetail joints, a carpentry technique that is as simple as it is sophisticated. By way of contrast, the Werkraum Bregenzerwald has established itself in Andelsbuch as a competence centre for wood. New furniture and objects in wood are exhibited at the werkraum depot, the showroom in Schwarzenberg. One particularly fascinating piece is a dowelled fountain in pine wood, with its clarity of design: the wooden dowels swell up when coming in contact with water, and the fountain – that can simultaneously be a bathing tub – becomes sealed. A further delight is wooden shoes: traditionally, these were the clogs worn when working on the farm. But with long-hair goatskin applied as the leather upper, they become an exhilarating celebration of fashion.
'Culture of wood' walk taking in the cultural and natural landscape of Vorarlberg, looking at architecture in the Bregenzerwald.
Architecture guided tours in Vorarlberg: www.v-a-i.at
Sleeping in/renting wood houses: www.holzhus.at
CREE: A skyscraper in wood


text: Nathan Binkert wrote: > > I have a Compaq Ipaq PDA with usb cable. I get: > > ugen0: Compaq SA1100 USB NIC, rev 1.00/0.00, addr 2 > > in dmesg. I would like to know if this is going to be supported or if > > there are availible kernel patches for it; or any other information > > relating to Ipaq and openbsd. > > Well, the first big thing is the software for such a device. It may work > fine with ugen if it works on one of the other *BSD's. If there is linux > software, it could probably be ported to use ugen. Kernel drivers aren't > always the solution for these sorts of devices. Unless they appear as > things like a disk drive, or a network adapter. > > Nathan The Ipaq is does Linux-to-Linux usb networking. It's usb-to-usb networking.


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News, trends and ideas we're tracking today.
Posts filtered on Tag
Request during foot chase: 'Can I come in a minute?'
KLTV.com-Tyler, Longview, Jacksonville, Texas | ETX News He may have been Texas' most polite suspect. Or maybe he is already in the Christmas spirit. A television station in Tyler reports that a man who was fleeing police on foot stopped by a house, looked through the glass door and had a question for the couple […] [Read More]
Man flees deputies with his kids in the car
A man was taken into custody after he led police on chase, fired a gun into the air and crashed his sports utility vehicle near Interstate 45 in southeast Houston Thursday night, all with his two small children in the SUV with him, officials said. Joseph Bostick, 37, is charged with evading arrest, two counts of endangering […] [Read More]
Wreck kills driver fleeing police near North Loop
One person died in a traffic crash during a police chase in north Houston early Tuesday morning, marking the second chase-related fatality in as many days in the Houston region. [Read More]
Cops: Driver put kids at risk during police chase
A 31-year-old man has been charged after he eluded police following a high-speed chase Wednesday while his children were in his pickup with him. The white F-150 Ford pickup was later discovered in Sealy, but the man remains at large and his children have not been found. Noe Soto-Aranda is charged with assault of a […] [Read More]
Suspect updates Facebook during chase: HPD
A man who led Houston police on a chase early Wednesday took the opportunity to multitask, updating his Facebook status during his unsuccessful getaway, KPRC-TV reported. According to the television station, the driver of a Mercury Grand Marquis refused to stop. During the slow speed chase, two passengers were able to get out of the […] [Read More]
Driver in police chase found under mobile home
Police chased down a driver who sped away from a traffic stop in the Arbor Oaks area off FM 1458 late Friday night, ultimately finding him hiding under his stepbrother's mobile home, according to the Montgomery County Police Reporter. The driver hit a deputy standing on the street and reached speeds of 100 mph during […] [Read More]
Houston police tracking suspect on foot
Houston police are searching for a motorist who jumped out of his vehicle Wednesday and fled on foot in northeast Houston, KPRC-TV is reporting: Houston police said officers tried to pull the driver over on the 610 Loop near the Eastex Freeway, but he took off. Officers chased the driver up and down neighborhood streets […] [Read More]
Police recover safe after wild SW Freeway chase
Police officers chased some suspects down the Southwest Freeway with what appeared to be a safe hanging out of the trunk, KTRK-TV (Channel 13) is reporting. [Read More]
KTRK: Authorities nab suspect in N. Harris County chase
After searching a wooded area near Kuykendahl in northern Harris County, authorities have captured the suspect in an emergency call that quickly escalated Monday afternoon, KTRK-TV reports on its website. It started when a woman, believing she was being followed, called 911. Precinct 4 deputy constables told her to pull into a Walmart at Interstate 45 […] [Read More]
Protest hits Chase Tower downtown
Protesters were gathered in front of the Chase Tower in downtown Houston at lunch time today. [Read More]
KPRC: Splendora police chase suspect into pond
Authorities in Montgomery County arrested convicted sex offender Tuesday after a chase that ended with the suspect crashing into a pond, according to KPRC-TV (Channel 2). [Read More]
KTRK: Man arrested after chase, wreck at Main and McGowen
A man was in custody after allegedly leading police on a chase through Midtown about 11:20 a.m. Saturday and causing a wreck that briefly shut down the intersection at Main and McGowen, KTRK-TV reports on its website. Authorities said the man tried to cross over the Metro light rail tracks at McGowen, struck another vehicle and […] [Read More]


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The invention relates to an organic field effect transistor which is especially characterized by a cross-linked, structured insulating layer (4) on which the gate electrode (5) is arranged. The structure of the OFET ensures that the gate electrode (5) of an OFET can be used as a strip conductor to the source electrode (2) of the next transistor and can be used in the construction of larger circuits.
1. Organic field effect transistor, comprising:
a flexible substrate;
a first layer on the substrate;
source and drain electrodes and a semiconductor in the first layer;
an insulator forming a second layer on the first layer, the insulator being pattern-formed and formed from an insulator material crosslinked with a crosslinker in the presence of a photoinitiator, the insulator pattern being produced by crosslinking the insulator in the desired pattern by photolithography with uncrosslinked insulator outside the pattern and then removing the uncrosslinked insulator material; and
a gate electrode on the second layer forming a third layer.
2. Organic field effect transistor according to
3. Organic field effect transistor according to
4. Organic field effect transistor according to
5. Organic field effect transistor according to one of
wherein the semiconductor is formed from conjugated polymers or oligomers.
6. Organic field effect transistor according to
7. Organic field effect transistor according to
8. Organic field effect transistor according to
9. Organic field effect transistor according to
10. Use of the organic field effect transistor according to
11. Use of the organic field effect transistor according to
12. Organic field effect transistor according to
13. Method far producing an organic field effect transistor comprising:
providing a flexible substrate with a source and drain electrode and a semiconductor;
forming an insulator from an insulator material crosslinked with a crosslinker in the presence of a photoinitiator by applying an insulator material solution containing an acid-sensitive crosslinker and a photoinitiator to the semiconductor;
exposing the insulator through a shadow mask covering the source and drain electrodes;
patterning the insulator pattern by crosslinking the insulator in the desired pattern by photolithography with uncrosslinked insulator outside the pattern and then removing the uncrosslinked insulator material including baking to effect the crosslinking and patterning of the insulator at the exposed areas; and
depositing a gate electrode on the thus crosslinked and patterned insulator.
14. Method according to
15. Method according to
16. Method according to
17. Method according to
18. Method according to
19. Method according to
20. Method according to
This is the 35 USC 371 national stage of international application PCT/DE02/00312 filed on Jan. 29, 2002, which designated the United States of America
The present invention relates to organic field effect transistors, so-called OFETs, with photopatterned gate dielectric as well as a method for the production thereof, and the use of said field effect transistors in organic electronics.
Field effect transistors play a central role in all areas of electronics. In order to adapt them to suit particular applications, it has been necessary to make them lighter and more flexible. The development of semiconducting and conducting polymers has made it possible to produce organic field effect transistors, all parts of which, including the semiconductor layer as well as the source, drain and gate electrodes, are fabricated from polymeric materials.
However, in the production of organic field effect transistors a plurality of organic layers have to be patterned one on top of the other in order to obtain an OFET of normal construction, as shown in
This problem has been solved using an organic field effect transistor as described in Applied Physics Letters 1998, page 108 et seq. A polyaniline-coated polyimide film is used as the substrate. In this first polyaniline layer, the source and drain electrode are formed by irradiation through a first mask. In this first layer, a semiconductor layer of polythienylenevinylene (PTV) is also formed, on which polyvinylphenol is then crosslinked using hexamethoxymethylmelamine HMMM. This layer is used as the gate dielectric and as an insulator for the next layer and the interconnects. A further polyaniline layer is finally formed thereon in which the second layer of interconnects and the gate electrode is defined by patterning. The vertical interconnects are produced mechanically by punching pins through the layers.
The above method prevents previously applied layers from being dissolved or otherwise damaged. However, it has been shown that in particular the last operation for forming the vertical interconnects (otherwise known as vias) does not permit the fabrication of complex circuits.
Applied Physics Letters 2000, page 1487 describes how this problem can be solved by providing low-resistance vias in the field effect transistor structure by means of photopatterning of photoresist material. To this end, another design of OFET, namely a so-called "bottom gate" structure, is regarded as indispensable. If a "top gate" structure of the same composition were produced, this would result in unacceptable contact resistances in the order of M
However, the construction and the operations for patterning this OFET with bottom gate structure are complex, making it impossible to manufacture particularly complex circuits economically.
The object of the present invention was therefore to specify an organic field effect transistor or a method for the manufacture thereof which permits the use of photolithography without attacking or dissolving the organic layers in all operations as well as making possible a construction which provides a simple means of vertical interconnection between conducting tracks at different levels in organic integrated circuits. The organic field effect transistors must at the same time be manufacturable cheaply and economically using simple operations.
The subject matter of the present invention is therefore an organic field effect transistor characterized in that, on a flexible substrate there are disposed, in a first layer, source and drain electrodes as well as a semiconductor on which, in a second layer, an insulator is pattern-formed and onto which, in a third layer, a gate electrode is deposited (top gate structure).
The organic field effect transistor according to the invention is light and extremely flexible, as it is only formed from organic layers which are mainly patterned by means of photolithography but without using photoresist. By means of the patterning of the insulator layer in particular, the gate electrode of the organic field effect transistor according to the invention can simultaneously be used as the conducting track to the source electrode of the next transistor.
Advantageous embodiments of the subject matter of the invention will emerge from the sub-claims 1 to 10.
Thus ultrathin glasses, but for cost reasons preferably plastic foils, can be used as the substrate. Polyethylene terephthalate and polyimide foils are particularly preferred. The substrate must in each case be as light and flexible as possible. As the thickness of the substrate determines the actual thickness of the device as a whole—all the other layers combined are only some 1000 nm thick—the substrate thickness must also be kept as small as possible, normally in the range of approximately 0.05 to 0.5 mm.
The source and drain electrodes can consist of wide variety of materials. The type of material will basically be determined by the type of fabrication preferred. Thus, for example, electrodes of indium tin oxide (ITO) can be produced by photolithography on ITO-coated substrates, the ITO being etched away from the areas not covered by photoresist. Polyaniline (PANI) electrodes can also be produced either by photopatterning or by photolithography on PANI-coated substrates. Equally, electrodes made of conductive polymers can be produced by printing the conductive polymer directly onto the substrate. Conductive polymers include, for example, doped polyethylene (PEDOT) or possibly PANI.
The semiconductor layer consists, for example, of conjugated polymers such as polythiophenes, polythienylenevinylenes or polyfluorene derivatives which are solution processable by spin-coating, silk-screening or printing. Also suitable for creating the semiconductor layer are so-called "small molecules", i.e. oligomeres such as sexithiophene or pentacene, which are evaporated onto the substrate by a vacuum technique.
However, an important aspect of the present subject matter of the invention is the way in which the insulator layer is created. This is a crosslinked insulator which is crosslinked and patterned by means of photolithography, i.e. under partial exposure. An insulator material is crosslinked area by area using a crosslinker under acid catalysis. Suitable insulator materials in the context of the present invention include poly(4-hydroxystyrene) or melamine-formaldehyde resins containing hydroxyl groups. The crosslinker is acid-sensitive, specifically hexamethoxymethylmelamine (HMMM). Acid catalysis is effected by means of a photoinitiator, e.g. diphenyliodonium tetrafluoroborate or triphenylsulfonium hexafluoroantimonate which produce an acid under the effect of light.
The present invention relates to a method for producing an organic field effect transistor wherein a flexible substrate is provided with a source and drain electrode as well as a semiconductor and is characterized in that an insulator is deposited on the semiconductor by applying an insulator material solution containing an acid-sensitive crosslinker as well as a photoinitiator, exposing it through a shadow mask covering the source and drain electrodes, and then baking it, crosslinking being effected at the exposed areas and the gate electrode being deposited on the thus crosslinked and patterned insulator.
Details and preferred embodiments of the method according to the invention will emerge from the sub-claims 12 to 18. The invention will now be described in further detail with reference to
In the accompanying drawings:
A conventional OFET consists of a substrate 1, source and drain electrodes 2 and 2′, a semiconductor 3, an insulator 4 and the gate electrode 5. The conventional OFET requires contact tags 6 for combining individual OFETs to form larger circuits.
As shown in
With the present method, the gate dielectric is therefore produced by photolithography without using photoresist. This results in an OFET whose gate electrode can be used simultaneously as the conducting track to the source electrode of the next transistor. This allows vertical interconnection between conducting tracks at different levels in organic integrated circuits.
An exemplary embodiment of this will now be disclosed, specifically indicating the reaction conditions.
5 ml of a 10% solution of poly(4-hydroxystene) in dioxan are mixed with 20 mg hexamethoxymethylmelamine and a catalytic trace of diphenyliodonium tetrafluoroborate and spin-coated onto a substrate already containing electrodes and semiconductor. The substrate is exposed through a shadow mask and then baked for 30 minutes at 120� C. After cooling, the insulator is removed at the unexposed and therefore uncrosslinked areas by intensive rinsing with or soaking in n-butanol. The gate electrode is formed thereon.
The OFETs according to the invention are ideally suitable for applications in the field of organic electronics and in particular for the production of identification stickers (ID tags), electronic watermarks, electronic barcodes, electronic toys, electronic tickets, for use in product or piracy protection or anti-theft security.
Patent Citations
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Referenced by
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Numbers Don't Lie
Any way you look at the numbers, the Ear Force X12 is the #1 selling video gaming headset of all time. This headset can speak for itself!
Superior Quality and Clarity
Amplified Stereo - Get an earful of top quality sound the way the game developers actually meant the game to be heard.
Deep Immersive Experience
Bass Boost - Gives your audio a kick in the you-know-what to add depth and realism to the sounds of the game.
Total Control Over Sound
Hear What You Want, When You Want - With Independent Game and Chat Volume, turn the game sound up and chat volume down. Or turn the chat up and the game down! The choice is yours.
Voice Level Recognition
Microphone Monitor - Know how people tend to scream when wearing headphones? Now you can hear your voice in your headset so you're not that guy.
PC Gaming - Play PC games, as well as, console games? Well the X12 allows you to plug and play on your PC right out of the box.
Filter Results
Cheap, but good.
This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: I have to give them 5 stars, because for the price they have served me very well.
Cons: Every pair of these you will buy will have the electrical interference static when you're using at high volumes, but only when no audio coming through.
Other Thoughts: I had to twist tie and stuff 4 ft of cord under my pc tower.
Did you find this review helpful?
Worked for a while...
This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: Comfortable for hours on end. Cheap for a headset.
Cons: Owned two of these because they fit that well and took exceptional care of both. Both sets were plugged in once and never relocated. The most abuse they got was removing them from stand to put on my head.
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Great Sounding Headset!
This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: I wear these mainly at night when I'm gaming because of thin walls in my house. They sound great to me. No problems. Like any pair of headphones they take a little while to get use to wearing especially if you have never worn gaming headphones at all or for long periods of time
Cons: Cords are a bit excessively long. If my computer was a distance away that would be understandable, or if I were to run the cords through the walls to hide them. Otherwise great headphones for the price
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Not happy
This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: the speakers are excellent, same as the px22, Ive used both.
Cons: Okay so when you turn up the game volume on the mini amp, it starts picking all sorts of weird noises from my computer so i have to turn it down to half way, the px 22 didnt do that.
Other Thoughts: Just go with the px22 model its much better, much much better.
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Best you can get at this price
This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: - Good sound quality.
Cons: - In-line volume knobs in an awkward place.
Other Thoughts: I've had these things for around 2 years and I've only ever been happy with them. I'm not rough on my equipment, but I'm not super delicate with it either, and these have held up without a single issue.
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Best headset I have ever owned
This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: Long cord, Bass boost, amazing sound quality, black/green color, speakers don't blow at full sound/full bass, surround sound
Cons: friends say the mic glitches sometimes
Other Thoughts: Amazing headset but if Turtle beach improved the mic even if it made the price go up it would be perfect
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Wonderful Headset
This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: Long Lasting
Cons: Mic can sometimes be heard by the people you are talking to and echo for them
Other Thoughts: I would 100% get this again for this price. If you are looking for a more expensive headset, then i would recommend Razer Tiamat 7.1, but if you only wana spend $60ish instead of $200 then this is the headset for you.
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Worth The Price
This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: It comes at a very affordable price, and at that price offers a very nice sounds quality. One part I especially liked was the 'feedback' on the mic, it was a good indicator of telling if your microphones was on and if you could be heard.
Cons: Broken Microphone after little use. I got this headset last year as a gift (I had no return information) and shortly after my computer's motherboard crashed, so I had to wait about 7 months to build a new one, when I did, after about a week of using the headset the microphone cut in and out, and I had to tweek the cable going in the side to get it to stay on, then it cut out all together, and I cracked it open the next day (Evidently a very stupid choice on my part). The X12 had shown clear signs of a wire being loose for the microphone, but for the life of me I could not find anything wrong, all the wires were seated properly in their solder, and none of their coat's were striped so far to cause shorting. After attempting to put it back together I snapped two wires our of their soldering, this was earlier today, thus, I'm still working on fixing my mistake. My point being, there was no obvious reason the microphone should've quit working but it did, and now I have to buy another headset just to get a microphone, needless to say I'm disapointed.
Other Thoughts: It's definitely worth the $50 price tag, and I feel the problem I had was an anomaly, but I would recommend sending it in if you have a problem with the microphone, as I could not find any fix for it and ended up damaging my headset more.
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This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: I got the same headsets from another retailer for a higher price. I like how they look and now I'm currently using the old ones. Just hope by the time I get to use the ones I bought for $35!! don't go "bad".
Cons: Having to hear your own sound is not so great. It could be annoying at times and will bug on TS because of the "hear your own voice" feature. Then again when you buying this product you should already know, I just didn't know it could be so annoying.
Other Thoughts: Wish there was a key or something to deactivate the "hear your own voice" feature.
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Bad Mic
This review is from: Turtle Beach X12 XBOX 360 Headset
Pros: The sound is decent, the low end is pretty nice actually. Which is what you're typically looking for in a headset if you play a lot of FPS games. The fact that it's interchangeable between PC, and Xbox is what initially drew me to this headset in the first place, very convenient.
Cons: The mic was awful from day one. People on Xbox would complain about a loud buzzing noise when it was plugged in, the buzzing went away on PC but people often complained that I sounded far away, and if I adjusted my mic closer the sound was blown out.
Other Thoughts: You get what you pay for, it's a cheap headset/mic combo.
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Archive for the 'fitness' Tag
When OK can become Awesome
This past weekend I went on a run that changed my life. I had started running a few months ago and slowly picked up advice on technique from here and there, changing my running style after getting each new piece of information. My runs had been good. Ok. But everything changed on my last run when I found my almost perfect form. And all it took was disciplined open mindedness.
Even simple things need practice
Running is a simple movement. You put one foot in front of the other. Yet, even this simple action needs practice or else you might become a fist-pumping, shoulder-rolling mass of swaying body parts that is wasting energy and causing pain and injury. In my case, my form started with arms swinging, and soft heel strikes rolling forward into a long stride. After forming this habit, I stilled my arms and tried landing on the front of my foot, almost on the balls of the feet and pushed off with my toes. As I moved through my practice, I was without a coach, but I drove myself forward to learn.
We are creatures of habit, but we need to listen to ourselves
I had made habits of the techniques, but did not think about adjusting the technique to my body. Instead, I thought about how I could force my body into the form that came from the authorities. This is a mistake. There are experts in different fields, but if we are mindful, we are the best qualified expert on ourselves. Human beings can become acclimated to most anything, good and bad: The constant stress of war, the hardship of poverty, or the work of regular diet and exercise. In my case, my running technique had resulted in a habit that provided me an ok run, and I acclimated to that, but because of my drive to improve, I realized "ok" could become awesome.
When things are ok, it's time for some experimentation
When I started out on my run, I had done the extremes, both soft and heavy steps on the heel, and bouncing off the balls of the feet. My practice, just like the meditative practice of a monk, made me familiar with my body. I knew how it moved and how my feet felt striking the ground. On this day, I started with heel strikes, short strides, and light steps.
As I warmed up, I moved up to the balls of the feet. Less than half mile in, I settled my feet into a mid-foot strike, my heels barely touching the ground before my foot picked up again. I placed my feet like this, step after step, getting a sense of the ground, in tune to how my feet touched the earth. At mile one, I felt the usual resistance melt away, but this time it was different.
As I placed each foot on the ground, it whipped back effortlessly, gliding over the ground rather than pushing off of it. It felt as if I wasn't in my body running, but a spectator. My mind had been evacuated and that left only my soul. And my soul was smiling.
At mile three, I was in awe. I thought, "Now this is what awesome means. Right here." I was unfettered. It felt like I had just started my run. It was incredible. After the fifth mile, I was nearing my car, where I'd started my run, and I thought about the comfort of stopping. After a couple of seconds, the thought faded away. I felt no anticipation for the end. My mind and its worries had surrendered to action. I was fully present running.
Immerse yourself, and after many trials, the answer will find you
Experiences like this are important in teaching me the value of immersing yourself in a task. Practice your passion. Be willing to form habits and just as willing to break them and try new ones to hone your skill. This will help us find a new way to do something which we never thought possible: Whether it's for running, running a business, or creating a product. We can then realize that ok can become awesome.
Is the easy life truly easy?
I was at the gym the other day, and I saw the cardio room filled with people, everyone moving on stationary machines, but going nowhere, and I laughed to myself. Later, on the way out, my laughter turned to amazement when someone told me about a projection keyboard her teacher used in her class. I didn't understand how a keyboard could be projected and still work. Then I got to thinking about how our entire economy was dependent on bankers buying and selling bets, and how that could work.
Sounds abstract? I think so, too. So…
Is it possible to make life too abstract?
In a previous blog. I talked about how exercise gives us a feeling of accomplishment which is needed in a society that seeks to make things easier. When I looked out on the rows of cardio machines last week, I saw something a little different. There were people running in place. I turned to the other end of the gym, where people were lifting weights, up and down, over and over again.
It's funny how we've replaced the work that gives us this exercise naturally, like washing clothes by hand, walking or biking to work, or raising and making our own food. We have specialized roles now, a machine washes our clothes or a laundromat offers to do it for us. Groceries provide us food, and a cook and a waiter who provide us meals. There are garbage men to pick up our trash and lawn service for our yards. We've got cars that we can drive, taxi drivers that can drive us, and car mechanics that will change our oil.
The same thing is happening with our retirement accounts. Instead of investing in stocks and bonds in companies we think are making a good product, we give our money to bankers and they make us money. They still buy stocks and bonds, but today we have added bets in the mix. These are bets that someone else's purchase is going to go up in value. You can even bet whether something will go down in value.
Sound abstract? I think so, too.
The easy decision is easy…at first
We use machines to make it easier to do things and get places. It's easy, but then we realize we bought a car that has 6 cylinders, instead of 4, and has cargo space for 6 people, and those things cost more. We realize that our sedentary lifestyle requires us to exercise. Not easy, because we must now pay money and make extra time to drive to a gym.
We've lost the knowledge of how to landscape a yard, or even change the oil in our car, and this makes us more helpless than before. And instead of making meals which we know the ingredients, we buy convenient meals which can contain sugars and fats that are out of our hands, hidden in the food.
Maybe most important, our investments are made by bankers. They send us statements that show that our little pile of money is ever increasing. It's easy. Until we realize we don't know what a derivative is, or a collateralized debt obligation, but we staked our future on them. We then realize that everything we're doing is postponing the cost. The cost of us not supervising the banker is measured by the number of lost jobs and failed businesses after the banks defraud us and mismanage our investments.
Sound abstract? I think so, too.
My cousin is vice-president of Securities at TD Bank. He might be able to help us sort it out. I asked him how the derivative collapse affected them. He said, "Not too much."
"Really?" I answered, surprised.
"We looked at mortgage derivatives as a possible investment. We didn't understand it, so we passed," he answered simply.
If something is too complicated, ask why that is.
Maybe then we can make our lives truly easier.


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Elton John doesn't do things by halves. He felt like shopping at the Harry Winston store yesterday in L.A., and even though he was accompanied by two bodyguards and partner David Furnish, he obviously wanted to be the center of attention without screaming "Look at me!" So he let his outfit do all the screaming for him. This is color coordination to the max, folks. Blue sunglasses, blue shirt, blue blazer, blue trousers and, last but not the least, those incredibly shiny blue brogues. We're honestly surprised he didn't get a blue rinse to go with all of that. Is it wrong that we want those shoes?
[Photo: Splash News Online]


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Previous Episode | Next Episode
Zak And The BeanstalkZak And The Beanstalk (1999) Season 1 Episode 11201- Dragon Tales Cartoon Episode Guide by Dave Koch
This page has been viewed 5 times this month, and 325 times total.
- Dragon Tales Cartoon Episode GuideEpisode GuideTelevisionSeriesCartoon
- Traditional Animation
- Adelaide Productions, Columbia Tri-Star Television Animation, Sesame Workshop, The Post Group
- Cartoon Characters: Emmy, Max, Ord, Cassie, Wheezie, Zak, Quetzal.
- Voice Actors: Andrea Libman, Danny McKinnon, Ty Olsson, Chantal Strand, Kathleen Barr, Jason Michas, Eli Gabay, Shirley Millner.
- Directed By Michael Hack.
- Produced By James Coane, Wesley Eure.
- Written By Jeffery Scott, Cliff Ruby, Alana Lesser.
- Music: Brian Garland, Jim Latham, David R. Barkley, Justin Caine Burnett, Nathan Furst; more Musicians ...
- First Aired on October 05, 1999.
- Originally Aired on PBS (USA).
- Running Time: 12 minutes.
- Season: 1
- Color
Cartoon Summary:
Emmy and Max bring Zak & Wheezie breadcrumbs and binoculars. Zak is convinced that something bad is happened to the do-re-mi birds. They're gone! Where could... (more)
Cartoon Video:
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Hold down Control (PC) or Command (Mac) key + mouseclick to select more than one option
|Avg. Dinner Entrée
|Greater than $25
|$18.01 - $25
|$12.01 - $18
|$7.01 - $12
|Less than $7
Posted by Mike on 03/12/2014
Me and my family have been going to gracias for as long as I can remember. always the same love and always the same great quality, we even make the now at least 1hr drive just grab a few burritos every month or or two, and always when we are around the area. Great prices, unbelievable food and such an authentic atmosphere ( has changed a little in the past 10years) you will never find a comparable bite to eat. Gracias is a must for any unsure restaurant goer.
Posted by Johanna on 06/18/2013
This place is definitely not one of my top picks but it was just alright. They have expanded the location which makes the restaurant look really nice, wish the food was better and the service
Posted by J Valencia on 11/12/2012
We get our food "take out" usually, mostly because of parking or lack thereof. We especially like their steak tacos. The tortillas used are a bit small so it can be messy with steak overflowing, but who's gonna complain about that?! We call our order in ahead and it's always ready when we get there. They've been there a long time so they must be doing something right.
Posted by Vicki P on 10/15/2012
Went there with a group and was very excited. The food came and half of ours was cold by the time it got to the table. I order the El Pastore combination plate and it was regular pork, not seasoned at all and it was over cooked. We will never be going back to this reataurant again which is a shame because last time we went we really enjoyed it.
Posted by Brian on 01/09/2012
Great Location, but the food has always been mediocre. I live in the immediate neighborhood, so I have been going here occasionally for years. It is convenient.
Posted by Party of 5 on 01/02/2012
Dear Garcia's Management- Thank you for your generous discount after a poor experience. First of, I wanted say, I spent about $2 in parking for about 2 hours right in the back of the restaurant. We walked in and met up with our other friends and was sat immediately. We were all very hungry. After about 10 minutes at looking at the menu, I flagged down a server and ordered our drinks (5 horchatas), an appetizer, and our main entrees. All is well after this point and after conversating for quite a bit, we noticed people who were sitting around us were getting their drinks and food (some parties 3 and more actually said down after our party). That's when I looked at the time and noticed we've been waiting a good 45-50 minutes. At this point, I knew something was seriously wrong. I flagged our server down and asked politely for our drinks. The server actually asked, "what drinks did you order?" Note, at this point we still have not gotten our appetizer. After another good 10 minutes, our drinks arrived. My buddy finally got fed up and approached the manager. He seemed understanding and tried to resolve the situation immediately. However, our server, was not professional, nor apoloegitic. She agued that everyone must wait and what we ordered was "special" and took longer to make. Come on man! (no tomatoes and extra beans on the burritos). At this point, it already surpassed an hour and finally our appetizer showed up cold and burnt. It was almost like its been sitting there for while. 3 minutes after the appetizer, the food came out and it was also cold. Come on Guys, I use to love Garcia's and now I've to share this experience with all my friends and family. To the management, if a situation like this happens, deal with it yourself instead of leaving it up to the server.
Posted by Derf on 11/05/2011
I have been going to Garcia's on Lincoln since they opened in early 1991. The burritos and tacos are still the same, as is the salsa verde and the pico de gallo., so the recipe is in tact. I must say they make among the best burritos in the city. The best burritos/ tacos I believe are at Taqueria la Zacatecena on the souhwest corner of California and Nelson. However, Garcias comes a very close second. The only drawback is the price. $9.24 for a steak burrito? Did I break a window? The prices for these have risen steadily through the years, that's for sure. They were only $3.75 when they first opened in 1991. I understand inflation, but come on now.....


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PH posts 1st Q growth of under 6%, study shows
April 20, 2011 11:37:00
MANILA, PhilippinesThe Philippine economy likely grew by slightly less than 6 percent in the first quarter due largely to exports, construction, remittances and industrial production, a joint research by First Metro Investment Corp. and University of Asia and the Pacific said.
In its latest joint research "The Market Call" released on Wednesday, FMIC-UA&P said weaker electricity sales and job generation were pointing towards a slowdown in first quarter gross domestic product (GDP) growth compared to the robust performance of the previous quarters. "Higher headline inflation rate also may eat up a part of consumer spending strength," it said.
The research noted that February sales of power distributor Manila Electric Co. had increased in terms of actual levels but were showing signs of an economic slowdown. Looking at annual growth rates, it is still following the downward trend established during Q4 2010 as it went down from Januarys 2.3 to 1.3 percent in February.
But the FMIC-UA&P research noted that Januarys industrial production had jumped by 25.8 percent while exports managed to keep their double-digit growth pace at 11.8 percent. It added that the government's fiscal picture seemed to be in order and remittances remained buoyant.
"All told, we think first quarter GDP growth is likely to ease, but probably, not by much," the research said.
In the fourth quarter of 2010, GDP grew by 7.1 percent, bringing the full year growth to 7.3 percentthe highest for the country in the post-Marcos era.
Despite the social unrest in oil-rich Middle East-North African region, FMIC-UA&P said remittances would likely remain buoyant as it observed that many Filipinos working in the Middle East were deciding to stay put.
On the other hand, inflation was seen remaining below 5 percent for the rest of the first semester. Thus, FMIC-UA&P does not expect any further policy rate changes for second quarter.
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We know the market. You run your business while we do the legwork to find you opportunities.
Our goal is to find savings that may not be the obvious to non-real estate professionals.
In Real Estate, there are a lot of dollars on the table. Every owner has their Broker - shouldn't you?
For the business owner is to find the ideal location to run their business.
For landlord with property for lease is to bring the best tenants to the their property in the shortest period of time and to eliminate vacancy.
For seller of commercial real estate is to bring acceptable offers quickly.
For the investor is to maximize the rate returns for their real estate portfolio.
Finally to compress time for all of the assignments we handle by uncovering and sharing real time real estate knowledge with busines and property owner?s within the east Hillsborough market.


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Fransiska Anggraini
"If you're a man and ate this fish, you would have a busy night with your woman. Guaranteed!" said a fish seller at Paotere fish market in Makassar during a recent visit. He was in the middle of cutting open a female black tip reef shark pregnant with three pups.
I was so tempted to reply, "Whatever happened to STMJ ("susu-telur-madu-jahe," a traditional concoction of milk, egg yolk, honey and ginger for stamina)? Do people still drink it for aphrodisiac?"
"Especially the young, their meat tastes very tender! They're best for grilling!" he continued, holding an unborn pup in his hands. He smiled with pride. The blood of the poor female predator puddled around his feet.
As he continued mutilating the female shark, he kept on coaxing me to either buy the baby sharks or their mother's meat. He said I should make a quick decision because shark meat was very popular and could be sold out within minutes.
He wasn't talking nonsense, of course. When I looked around, a crowd had already gathered, waiting for their shark meat. Some even pre-ordered their share.
I asked the seller if he was aware that shark meat is poisonous. "Poisonous? Really? No way! Where did you hear that? All I know is, it tastes great and makes me a lot of money!"
Being Left in the Dark
It is estimated that 100 million sharks are killed every year.
That was a wake-up call to the fact that the road to banning shark trading is still long and winding. Blaming the fishermen just wouldn't solve the problem. It's the consumers who urgently need to receive information that consuming shark meat is bad for their health because it contains high levels of mercury.
Mercury consumption, even at low doses, can be very dangerous, especially for children and pregnant women. Brain damage leading to mental disabilities is one of the side effects, in addition to increasing the risk of heart disease. If shark meat is believed to increase masculinity, as claimed by those fishermen in Paotere, ironically, the mercury content lowers sperm count and, in the long run, causes erectile dysfunction and even sterility.
Mercury-Infested Meat
Sharks are prehistoric animals that have gone through many evolutions over the course of 420 million years. Yes, they're as ancient as the dinosaurs. Sharks are the top predators in the food chain of the marine ecosystem. They eat smaller fish in the sea that already have mercury in their meat. The mercury level in the sea has now significantly increased as there are more and more off-shore pollution.
Sharks can live up to 50 years — or sometimes more — and they eat a lot of fish during their lifetime. Imagine the amount of the mercury that accumulates in sharks. When humans eat any shark products, the accumulated mercury is transferred into their bodies.
Mercury content cannot be reduced by cooking. When it's already there, it stays there.
Consuming sharks has more dangers, not only to our bodies but also to the environment. Without sharks, there will be no predators to eat the smaller fish, which can cause their population to become uncontrollable. Sharks with, their great sense of smell, are mainly attracted to wounded or sick fish. So in this case, sharks help get rid of the bad quality fish from the sea.
Thus, if we want to eat good quality fish or other seafood items, we should let sharks help us. We need sharks alive more than when they're served in a bowl.
What to Do?
What to do if you find shark items on a restaurant menu? Ask for the restaurant manager and clearly state that you changed your mind about eating there because they serve shark items. Tell them it is not acceptable to serve sharks. Sharks are both poisonous and endangered species.
The action should start from us, customers, to convince those fishermen to stop catching sharks. If we don't buy, they will finally get the message that the tender meat of a baby shark just isn't worth the killing.
And it's high time the authorities took the initiative to spread the news how shark meat contains at least 1,400 micrograms of mercury per kilogram.
Contrary to popular belief, only a few shark species are dangerous to humans. Sharks don't eat humans. It's us, humans, they're more afraid of because we slaughter them mercilessly in the name of having a busy night with a certain woman.