text:
Proteomics Approaches to Understand Linkage Between Alzheimer's Disease and Type 2 Diabetes Mellitus
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ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
Volume 14, 10 Issues, 2015
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CNS & Neurological Disorders - Drug Targets
Formerly: Current Drug Targets - CNS & Neurological Disorders
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Proteomics Approaches to Understand Linkage Between Alzheimer's Disease and Type 2 Diabetes Mellitus
CNS & Neurological Disorders - Drug Targets,
13(2): 213-225.
Zeenat Mirza, Ashraf Ali, Ghulam Md. Ashraf, Mohammad A. Kamal, Adel M. Abuzenadah, Adeel G. Choudhary, Ghazi A. Damanhouri and Ishfaq A. Sheikh
Proteomics & Structural Biology Unit, Fundamental & Applied Biology Group, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia.
Alzheimer's disease (AD) is a progressive neurological disease of the brain leading to the irreversible loss of neurons and intellectual abilities. Diabetes mellitus type 2 (T2DM) is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. The prevalence of AD and T2DM is increasing at an alarming rate and has become a major public health concern worldwide. The clinico-pathological relationship between AD and T2DM has been debated for more than a decade. Recent epidemiological studies have provided direct evidence that T2DM is a strong risk factor for AD and numerous studies have demonstrated that patients with diabetes have an increased risk of developing AD as compared with healthy individuals. The underlying biological mechanisms that link the development of diabetes with AD are not fully understood and therefore are worth intensive research. The existence of proteomic links between AD and diabetes is an important topic currently under active debate. An understanding of the complex association between diabetes and AD is necessary for the development of novel drug therapies and lifestyle guidelines aimed at the treatment and/or prevention of these diseases. This review aims to summarize what is currently known about the biological and especially proteomic relationships and similarities between these two age-related devastating diseases of modern day life. This study may also aid in future for the identification of a single or a panel of potential blood-based protein biomarkers for early diagnosis of AD and T2DM with high sensitivity and specificity.
Alzheimer's disease, diabetes mellitus type 2, biomarker, proteomic linkage.
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text:
Marshall Scholarships
(Any field of study)
Website: http://www.marshallscholarship.org
Campus deadline: April 15, 2014; second point of entry: August 4, 2014
Final deadline: October 1, 2014
Description: The Marshall Scholarship looks to support intellectually distinguished young Americans who are likely to be strong leaders in their fields to study in the U.K., to gain cultural understanding, and to act as ambassadors between the U.K. and the U.S.
Term: Typically two years, leading to a graduate degree. Limited one year scholarships are available.
Amount of support: The scholarships are tenable at any British university and cover two years of study in any discipline. The total value of a Marshall Scholarship varies according to the Scholar's university, but averages about £23,000.
Number of scholarships: approximately 40 per year.
- Be a U.S. citizen;
- Hold an undergraduate degree from and accredited four-year college or university in the United States by the time the scholarship is taken up;
- Have a GPA of not less than 3.7 on their undergraduate degree;
- Have graduated from their undergraduate college or university after April 2010;
- Not have studied for, or hold a degree or degree-equivalent qualification from a British University.
Application Procedures: Candidates must be endorsed by the university, which means a competitive selection process on campus. Endorsed candidates will complete an online application, including several short essays. The application requires four letters of recommendation. See the Preliminary Requirements for U.K. application.

subset: commoncrawl


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A "Wikipedia" for neuronsMarch 31, 2015 8:43 am | by Jocelyn Duffy, Carnegie Mellon Univ. | Comments
The decades worth of data that has been collected about the billions of neurons in the brain is astounding. To help scientists make sense of this "brain big data," researchers at Carnegie Mellon Univ. have used data mining to create www.neuroelectro.org, a publicly available Website that acts like Wikipedia, indexing physiological information about neurons.
Wearable technology can help with public speakingMarch 31, 2015 8:34 am | by Leonor Sierra, Univ. of Rochester | Comments
Speaking in public is the top fear for many people. Now, researchers from the Human-Computer Interaction Group at the Univ. of Rochester have developed an intelligent user interface for "smart glasses" that gives real-time feedback to the speaker on volume modulation and speaking rate, while being minimally distracting.
Black-hole wind linked to galactic gush of star-forming gasMarch 26, 2015 8:33 am | by NASA Goddard Space Flight Center | Comments
By combining observations from the Japan-led Suzaku x-ray satellite and the European Space Agency's infrared Herschel Space Observatory, scientists have connected a fierce "wind" produced near a galaxy's monster black hole to an outward torrent of cold gas a thousand light-years across. The finding validates a long-suspected feedback mechanism enabling a supermassive black hole to influence the evolution of its host galaxy.
Manufacturing process could yield better solar cells, faster chipsMarch 25, 2015 10:57 am | by Tom Abate, Stanford Engineering | Comments
Computer chips, solar cells and other electronic devices have traditionally been based on silicon, the most famous of the semiconductors, that special class of materials whose unique electronic properties can be manipulated to turn electricity on and off the way faucets control the flow of water. There are other semiconductors. Gallium arsenide is one such material and it has certain technical advantages over silicon.
Best look yet at "warm dense matter" at cores of giant planetsMarch 25, 2015 8:30 am | by SLAC National Accelerator Laboratory | Comments
In an experiment at the SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as it transitions into a superhot, highly compressed concoction known as "warm dense matter." Warm dense matter is the stuff believed to be at the cores of giant gas planets in our solar system and some of the newly observed "exoplanets" that orbit distant suns.
Turn the light onMarch 25, 2015 8:06 am | by Lynn Yarris, Lawrence Berkeley National Laboratory | Comments
In the on-going search for a better understanding of how the brain and central nervous system develop, a potentially powerful new tool could soon be available. Researchers at Lawrence Berkeley National Laboratory have discovered a light-sensitive opsin protein that plays a surprising and possibly critical role in neuron maturation and circuit formation.
Light as a puppeteerMarch 18, 2015 9:24 am | by Laura Petersen, OIST | Comments
Researchers at the OIST have demonstrated a more robust method for controlling single, micron-sized particles with light. Passing light along optical microfibers or nanofibers to manipulate particles has gained popularity in the past decade and has an array of promising applications in physics and biology. Most research has focused on using this technique with the basic profile of light.
Minimal device maximizes macula imagingMarch 18, 2015 7:49 am | by Mike Williams, Rice Univ. | Comments
A smart and simple method developed at Rice Univ. to image a patient's eye could help monitor eye health and spot signs of macular degeneration and diabetic retinopathy, especially in developing nations. The patient-operated, portable device invented at Rice is called mobileVision. It can be paired with a smartphone to give clinicians finely detailed images of the macula, without artificially dilating the pupil.
"Smart bandage" detects bed sores before they are visibleMarch 17, 2015 2:23 pm | by Sarah Yang, Univ. of California, Berkeley | Comments
Engineers at the Univ. of California, Berkeley, are developing a new type of bandage that does far more than stanch the bleeding from a paper cut or scraped knee. Thanks to advances in flexible electronics, the researchers have created a new "smart bandage" that uses electrical currents to detect early tissue damage from pressure ulcers, or bedsores, before they can be seen by human eyes, and while recovery is still possible.
Graphene membrane could lead to better fuel cells, water filtersMarch 17, 2015 12:32 pm | by Walt Miss, Penn State Univ. | Comments
An atomically thin membrane with microscopically small holes may prove to be the basis for future hydrogen fuel cells, water filtering and desalination membranes, according to a group of 15 theorists and experimentalists. The team tested the possibility of using graphene as a separation membrane in water and found that naturally occurring defects allowed hydrogen protons to cross the barrier at unprecedented speeds.
Researchers collaborate to develop revolutionary 3D printing technologyMarch 17, 2015 10:30 am | by Univ. of North Carolina, Chapel Hill | Comments
A 3D printing technology developed by Silicon Valley startup, Carbon3D Inc., enables objects to rise from a liquid media continuously rather than being built layer-by-layer as they have been for the past 25 years, representing a fundamentally new approach to 3D printing. The technology allows ready-to-use products to be made 25 to 100 times faster than other methods.
Maps predict strength of structuresMarch 16, 2015 7:36 am | by Mike Williams, Rice Univ. | Comments
Mother-of-pearl, the iridescent layer in the shells of some mollusks, inspired a Rice Univ. study that will help scientists and engineers judge the ultimate strength, stiffness and toughness of composite materials for anything from nanoscale electronics to buildings.
Necklace can help track food intakeMarch 13, 2015 11:05 am | by Bill Kisliuk, Univ. of California, Los Angeles | Comments
A sophisticated necklace developed by researchers at the Univ. of California, Los Angeles, can monitor food and drink intake, which could help wearers track and improve their dietary habits. The inventors of the WearSens device say it could help battle obesity, heart disease, diabetes and other problems related to nutrition.
Magnetic brain stimulationMarch 13, 2015 7:54 am | by David L. Chandler, MIT News Office | Comments
Researchers at Massachusetts Institute of Technology have developed a method to stimulate brain tissue using external magnetic fields and injected magnetic nanoparticles: a technique allowing direct stimulation of neurons, which could be an effective treatment for a variety of neurological diseases, without the need for implants or external connections.
Engineers solve mystery of dancing dropletsMarch 12, 2015 8:17 am | by Tom Abate, Stanford Engineering | Comments
A puzzling observation, pursued through hundreds of experiments, has led Stanford Univ. researchers to a simple yet profound discovery: Under certain circumstances, droplets of fluid will move like performers in a dance choreographed by molecular physics.


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This is Google Map Direction plugin used to display direction path in map or way for how you can go from source place to destination place.
No reviews yet! Be the first to review this plugin!
You must log in to submit a review. You can also log in or register using the form near the top of this page.


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Hold down Control (PC) or Command (Mac) key + mouseclick to select more than one option
|Avg. Dinner Entrée
|Greater than $25
|$18.01 - $25
|$12.01 - $18
|$7.01 - $12
|Less than $7
Posted by SuzC on 05/01/2014
Beautiful decor, young, hip owners, classic Mexican with a twist! Very fresh, you won't be disappointed!
Posted by MARIO on 01/06/2012
Went there on a jazz night. Music was great, but a bit loud. The poblano soup was memorable to say the least. Wish I could have taken a gallon of it home. The al pastor tacos were very tasty. I sampled all plates at my table (6) and all were very good. I strongly recommend this restaurant. BYOB.
Posted by Colleen B on 11/07/2011
This was my second time at DeColores. My daughter and I went there for brunch last May and really enjoyed it. The highlight of our meal was the crawfish and scallop soup. I had been dreaming of it. Tonight was my birthday and I chose to return, just for the soup. My son, daughter-in-law and daughter treated me to dinner. It was great! The soup was as delicious as I remembered. My daughter-in-law had the poblano soup, which was also outstanding. Chef Sergio came out of the kitchen and made some suggestions. I had the pork tenderloin marinated in pineapple salsa, wonderful. My son had the Carne Asada Chimichurri, with a side of the poblano cream sauce, Daughter -in -law had the Tampiquena, and my daughter had the vegetarian burrito. All were excellent. We chose to share the coconut tres leches and the cheesecake flan for dessert. Both were outstanding. The art work on the walls was interesting, if not a bit disturbing, but I understand it changes regularly. I highly recommend this spot. We brought our own wine, as it is BYO, but were told that they are hoping to get their liquor license soon. They do offer their own margarita mixes, which sound delicious, as well as Bloody Mary mix and michelada mix. I highly recommend that you check out this neighborhood gem.


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Switch out your knobs and make changing tones way easier.
The OKnob uses a friction-based grip to replace your factory knob and fit tightly in its place. It is made out of very durable materials so that it can withstand being tossed around in your gig bag.
Traditional effects pedal knobs may be different sizes on the outside, but they all have a very similar size hole on the bottom side of the knob. Option Knob designed 2 different OKnobs, the Classic and the Boutique, which cover the entire range of knob shafts so that it will ensure a snug fit when you replace your factory knob. In seconds you can install the option knob on your favorite vintage pedal, or on your brand new pedal that you bought today!
The Classic OKnob works on traditional pedals such as Boss© and DOD©. The Boutique OKnob is specially designed for "boutique style" pedals which have a larger knob shaft diameter.
Various styles available. See drop down menu to choose.


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I didn't expect this to happen. I didn't expect all of my free time to be absorbed and continuously sucked in. It has been almost two years since I placed my hands on Persona 3: FES, and now I have my hands on its portable sibling: Persona 3 Portable for the PSP. Have I missed playing the game that much?
Perhaps I have missed it. I smiled at the screen over the hours, remembering the various characters and their plight to stop the shadows. This time around, the female protagonist provides a pleasant "what if" scenario. It's nice to see the new social links, especially those with your party members. Junpei and Akihiko are some of the newest examples and give their characters more depth than previously seen.
As such, the game plays out almost the same as its twin. Your protagonist goes to school, interacts with people to make links (the stronger the bond, the stronger the persona of that arcana during fusion), raises characteristics (courage, academics and charm), have a part time job and explores the nightmarish labyrinth known as "Tartarus." However, you no longer run around in a 3-D world during the day. You "click" on hotspots on a map. These range from simple stairs, people you can talk to, objects you can inspect and, of course, social links. It all runs very smoothly and keeps the action marching forward. Load times are quite reasonable. It's only when you begin to explore the floors of Tartarus that the game's loading times are on par with the PlayStation 2.
But it comes at a price: Part of the game's narrative is lost. You don't get to see every little action and gesture like in the original. Some of the movies, especially those in the beginning, have been compressed or reduced to a simple cutscene to fit onto the disc. As such, there is a bit of a show-versus-tell problem. Thankfully, the portraits are retained, their faces moving to the dialogue occurring in front of them.
Exploring Tartarus is still done in 3-D. You run around the floors, exploring and hunting down shadows. If you feel like fighting, attack a shadowy blob. If not, run around them. Some floors will house weak or potent creatures (a "shadow den," if you will), and the clock on the ground floor might heal everyone for a reduced priced. This time around, the date influences which party members can come. Most of the time, everyone can go. But as mentioned, previous engagements might keep them away. Examples of this are the ever popular mid and final exams.
Furthermore, battle's system of "1 More" has been further refined. Right from the get-go, you can assume control of your allies and equip them from the menu screen. In the original, multiple hit abilities had to cause a "critical" attack on all of them to earn an extra turn. Now as long as one critical hit occurs, it will count. Furthermore, whenever a critical hit occurs, there is a chance that one of your allies will offer to join you in a co-op attack. This is a guaranteed critical hit.
The Velvet Room returns as well. It's just as you remember it: soothing opera music, opportunities to fuse and record personas, take sidequests and read entries on the personas. The main thing is now you have opportunity to choose between Elizabeth and Theo. The inclusion of Theo, while he has the same personality as Elizabeth, nicely balances out the inclusion of the female protagonist.
Sound design wise, this is almost exactly how you remember Persona 3. The slashing of swords, the fast whiz of arrows, the burns of fire, coolness of ice, wind ... and so forth. The music has been remixed. One of the tunes has been removed, while a few have been added. But the soundtrack is still as "funky," or eclectic if you prefer, as ever. The same techno piano music heard during exploration, the heavy guitar riffs during boss battles, a Japanese pop song heard during free time, the dorm's rap song and the ever-popular horn fare for social interactions. What constantly amazes me is how much voice acting is on the disc. Every important plot point is fully voiced by the original cast. It's still amusing and poignant as the original.
As such, I love Persona 3 Portable almost as much as the original. I miss the original's method of showing the plot, but it feels like a small price to pay to make a game portable. The compromises necessary to make it work are minor. The essence of Persona 3 remains intact. Here is one of those rare games that feels completely natural on the big screen as it does nestled between two hands. This is one of those games that will have its fans awake past their bed times and other obligations.
Thus, even if you own the PS2 version, it is still worth the admission. You have two different sides of the same story for the price of one. The game has been rebalanced and is just as fun. While I am still partial to the PS2 version, Persona 3 Portable is able to stand on its own two feet just as well as its siblings. And if you own a PSP and not a PS2, then you really should add this to your gaming library. So, let us return to the night. It is still young, and there is time to let the shadows play.


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On Mavris: Hard-working attacker who continues to improve ... provides depth on attack.
2008 (Junior): Played in eight games in a reserve role for Maryland.
2007 (Sophomore): Played in seven games, recording a goal and an assist while securing two draw controls ...first-career assist at Virginia Tech (4/22) ... one goal against Loyola (4/13) and got the first two draws of her career against Brown (3/10).
2006 (Freshman): Appeared in four games, recording a goal and a ground ball ... picked up the ground ball against Ohio (2/19) ... scored her first-career goal versus Old Dominion (3/18).
Prep: Standout player at Chesapeake High for coach Denise Thompson ... as a senior, was captain for the soccer, basketball and lacrosse teams ... Washington Post All-Met honorable mention as a senior ... first team all-county selection ... first team All-Galaxy playing with the CCLax club team ... Chesapeake's "Minds In Motions" honoree, recognizing the school's top student-athletes.
Personal: Alexandra Mavris was born Nov. 10, 1987 ... daughter of Cathy and Mark Mavris ... has one older brother, Mark ... lists her parents as the people she admires most ... chose Maryland because of the winning tradition ... is inspired by her roommate: women's basketball standout Marissa Coleman ... selected the Terps over American and Virginia Tech ... majoring in communication.
Mavris' Career Statistics


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A major aspect of my application is that in addition to tenant provided content, there is a quantity of 'canonical content' that gets updated once a quarter. I am making it available for both search and retrieval. I'm looking for a more production worthy way to accomplish this.
Prior to the release of DSE 2.0, this content existed in both Cassandra (non-search) and Solr. For the former, the content build process generates SSTables using org.apache.cassandra.io.sstable.SSTableSimpleUnsortedWriter, and the latter by generating native Solr XML formatted files. Being pre-production at the time, and only using a single Cassandra node, it was pretty straightforward to shutdown Cassandra, and replace the SSTables with the new ones. Likewise for Solr, I could remove the old index and ingest the new Solr XML files.
Regardless of DSE 2, moving to multiple Cassandra nodes requires more finesse than my procedure above. It seems what I need to do in that case is described here:
However, Sylvain's blog post is dated August 1, 2011 and speaks of Cassandra 0.8.1. Is using sstableloader still the way to go in the Cassandra 1.0.x, and soon to be 1.1, world? I'm already generating the SSTables, but they need to be uploaded to the cluster rather than just a single node.
With DSE 2, it sounds like I can continue to index the existing Solr XML files I generate, or more directly upload the new content directly into Cassandra, also using sstableloader. The search related keyspace and column family (Solr core) definition may or may not change as well for a given quarterly update.
With Solr today, I can issue a deletion query and remove all documents, then process a series of files to define the new content, and at the end of that, issue a commit. Once that has finally completed, then new queries will use that data. Until then, current searches will continue to refer to the old content. Is there a way to accomplish something similar going through Cassandra via sstableloader? I'm guessing the content will be updated as it goes, becoming eventually consistent across the cluster.
I suppose another approach would be to create a new version of the core via the HTTP API, then bulk load the content, and then instruct my app to then refer to the new core. The name of the current content core could be set in Cassandra itself, which the app will read and start using. At some point, the old core can be deleted. I kind of like this approach since I'll only have to deal with SSTables and Cassandra, and not Solr XML etc.
Finally, the canonical content is comprised of numerous multi-valued fields. If I pull up such a document field in the CLI, I see:
(column=n_macromolecule_species, value=solrjson:["Human","Mouse","Rat","Cow"], timestamp=1333552307242000)
Is that column value a standard I can make use of to define multi-valued fields, or is it some secret DSE Solr integration thing?


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Drug Compare
1 2
- Basic Info
Generic: Cafcit
It is used to help premature babies to breathe more regularly
What is this medicine?CAFFEINE (KAF een) is a stimulant. It is used to help premature babies to breathe more regularly.
What should I tell my health care provider before I take this medicine?They need to know if you have any of these conditions:
How should I use this medicine?Give this medicine by mouth. Follow the directions on the prescription label. Use a specially marked oral syringe to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. You will be taught how to prepare and give this medicine. Use exactly as directed. Do not give this medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as newborn for selected conditions, precautions do apply.
What if I miss a dose?If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
What should I watch for while using this medicine?Visit your doctor as directed. Tell the doctor or healthcare professional if your child's breathing does not start to get better or if it gets worse. The doctor may order important blood work.
If you are breast- feeding an infant who is taking this medicine, watch your diet. Avoid food and drinks that contain additional caffeine, like coffee, tea, colas and chocolate. Some of the caffeine you eat will pass to the infant with breast- feeding.
1 2
Copyright © 2005 - 2015 Healthline Networks, Inc. All rights reserved for Healthline. Healthline is for informational purposes and should not be considered medical advice, diagnosis or treatment recommendations. Terms of Use | Privacy Policy


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St. Vital Park will see a new pavilion for its duck pond.
The City of Winnipeg announced further details on the $2 million that will be spent on the park as part of the latest capital budget. The new pavilion will come with a price tag of $1 million, and another million will be spent to replace the washroom facility and the park's boat launch.
The pavilion design, called 'Wing', features a roof suggestive of a bird's wing in flight, according to a press release from the city. The roof will cover two different picnic zones.


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Gear Question
My feet are pretty wide with a high arch,...
My feet are pretty wide with a high arch, would this shoe work for me? I already own one pair of keen shoes that are size 8, so should I get the same size?
I have very high arches and my foot is fairly wide as well and this shoe fits great. The arch could be higher without a problem for me, however I think it is decent compared to how other similar shoes are. They do rub a bit on the heal initially, but nothing a few band-aids for a while won't cure!
View More Details on KEEN Harvest MJ Shoe - Women's


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Who Are We
DuckHouse Events provide a one-stop shop for your marketing needs.
Why Clients Choose Us
The services we provide clients guarantee impressive ROI results.
About DuckHouse Events
We provide event marketing services and brand awareness for clients.
100% People Orientated
Dedicated & passionate about creating bespoke marketing strategies.
Top News
DuckHouse Events Talk Growth & Productivity
There are plenty of businesses who have suffered in the recent economic climate,Read More
Creating A Compelling Brand
Before you can even think about the sale, you need to capture customers' hRead More
Tips On Creating Creative CV's
There is so many different tips and tricks out there when it comes to creating aRead More
Event Marketing Is For Success
Every entrepreneur is looking for that gap in the market. Some industries work bRead More
What We Stand For
"At the heart of our goals lies determination and the drive to do the right thing for our clients.
By ensuring our client hit their goals, the ripple effect is that we do too.
This is why any new brand that we start working with can have peace of mind that we will do a great job."
Why Choose Us?
- Bespoke Service
- In-Person Approach
- Consulting
- Feedback & Analysis
- Quality Results
- Dedicated Team
Our Services
- Event Marketing
- Client Representation
- Brand Awareness
- Sales Implementation
- Project Management
- Industry Knowledge Advancement
Tailored To You
Strategies designed and tailored with our clients and their customers in mind.


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they sell Burger King fries at bodegas?
In Wake Of Exec "Accidentally" Stabbing A Cab Driver, Morgan Stanley Insists You Ask, "What Would The Post Say?"
A year ago this Friday, a Morgan Stanley banker named William Bryan Jennings attended a couple holiday parties, drank a few Coors Lights, and around 10:30PM hailed a cab and asked the driver, Helmy Ammar, to take him home to Connecticut. On the way, a hungry WBJ requested they stop at G&G Deli off 10th Avenue, where he bought "a 20 oz. bottle of Aquafina water, a sandwich and some Burger King cheesy fries." As the cab entered approached Jennings' hometown of Darien, a dispute reportedly broke out as to what the fare for the ride would be. Ammar claims that they'd agreed on $204 before leaving Manhattan, but once in Connecticut, Jennings said he'd only pay $50. Jennings claims that Ammar jacked the price up to $300 and was unhappy when the banker offered $160. Another matter of he said/he said is whether or not Jennings started shouting racial slurs at Ammar and told him, "I'm going to kill you. You should go back to your country!" (Jennings denies this happened and says that Ammar locked the doors and wouldn't let him out of the cab.)
The one aspect of the story that is not in dispute is that as tensions flared, WBJ whipped out a pen knife he had in his pocket. For those of you reading from Morgan Stanley, this is where the teachable moments occurs: if you ever find yourself in a situation wherein you're winding up to stab a cab driver in the hand, stop and ask yourself, "Is this going to look bad in the Post tomorrow morning?" Jennings did not and now this is happening:


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NARS Cosmetics – Cream Blushes – Swatches
Gold Member, Penny Lane, Cactus Flower, Constantinople
NARS Cosmetics – Cream Blushes – Swatches
To complement the product photos, here are the swatches for some of NARS' cream blushes!
Where to Buy: Nordstrom.com.
Cactus Flower, Constantinople, Gueule de Nuit, Montenegro
Montenegro, Lokoum, Turkish Red
Discussion and debate are highly encouraged, and we expect community members to participate respectfully. When asking a question, please check the FAQ section (above) for information about purchasing, price, dupes, and the like. If you have general feedback or need technical support, please contact us.
Comments that include advertisements, self-promotion, insults, etc. may be in violation of our comment policy and subject to deletion. Please see our comment policy for more information.


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Those who were waiting for quick developments on a Motorola DROID 4 overclock can stop looking for one. New modules have been released for the newly-launched device which make it possible to overclock the OMAP4 processor from 1.2GHz to 1.4GHz. It's not a huge jump – in fact, it probably won't make much of a difference – but it's nice to know that the option is there. Head here and look for your correct module. Be sure to read all instructions before proceeding and remember that anything you do to your phone cannot be blamed on evil kittens or Phandroid. [via BriefMobile]
Continue reading:
- Verizon approves Motorola DROID 4's Jel
- Motorola DROID 4 soak test invites being sent
- Root checker found in DROID 4 and DROID RAZR/
- Motorola says ICS for DROID 4 now rolling out
TAGS: Motorola Droid 4


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We Try Evolution Fresh Juices from Starbucks
Starbucks tends to stay pretty close to home turf of coffee drinks and pastries. Sure, it makes the occasional foray into breakfast food, but half-caf lattes and mocha Frappuccinos have always been its bread and butter. So it's big news when Starbucks announces its intentions to get into fresh juice—launching the first Evolution Fresh juice bar in Bellevue, Washington this Monday. How are the juices? We decided to find out. More


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By Linda D. KozarynAmerican Forces Press Service
WASHINGTON, Sept. 11, 2000 "How's it going?" Bernard Rostker recently asked a soldier during a room inspection at Fort Carson, Colo.
"I'm really ticked off," the soldier candidly told the undersecretary of defense for personnel and readiness. "They dragged me back from Bosnia to go to school. I could've gone to school later."
This is one of the stories Rostker tells to illustrate how service members feel about today's military missions. After visiting troops around the world, he's concluded service members value real-world operations. And in return for their dedicated service, DoD is working hard to improve service members' quality of life.
In a Sept. 7 interview, Rostker said people join the armed forces for a variety of reasons, but there's only one reason they decide to stay in -- the love of 'soldiering.'
"What keeps a sailor in a purple shirt pulling fuel lines on an aircraft carrier deck in the middle of the North Atlantic? What keeps a soldier driving a 70-ton stabilized tank over hill and dale, firing on the run at Fort Hood, Texas?
"It's the excitement," Rostker said. "It's the thrill of it.
"Ultimately, you've got to love it or you wouldn't endure the family separations or working outdoors in the winter cold or in the Sinai's 133-degree heat. It is the profession of arms. You come in for a lot of reasons. But you don't stay unless you're a warrior."
Even after nearly 32 years of service within the Defense Department, Rostker said, he continues to be impressed by America's men and women in uniform.
"I sat in on a morning brief in Incirlik, Turkey, for Operation Northern Watch. It was like they were talking in code," he recalled. "They went through how they were going to stage a combat air patrol with all its supporting aircraft. It was the height of professionalism."
Rostker said the most remarkable change in the armed forces in the last 10 years is how what DoD call's 'operations other than war' have been legitimized. "They've been legitimized by the troops who patrol the streets in Bosnia or in Kosovo who know they are doing important things," he said. "Their infectious enthusiasm has convinced the military leadership that this is, in fact, the way a great power acts in the 21st century."
Today's service members are helping bring peace to the world, just as did those who served during World War II, Rostker said. "It's just as true today in the Balkans, the Middle East and elsewhere," he said. "These troops know it's important. They re- enlist for it. They want to get back to doing it."
In the past three years, he noted, U.S. forces displayed their military skills evacuating U.S. Embassy personnel in the Congo and providing quick, vital assistance following the August 1998 bombings outside the U.S. Embassies in Nairobi, Kenya, and Dar es Salaam, Tanzania.
They successfully conducted Operation Desert Fox in the Persian Gulf, Operation Allied Force in the Balkans, as well as strikes against Osama Bin Laden in the Middle East. U.S. forces continue to serve in peacekeeping missions in Bosnia, Kosovo and the Persian Gulf. Most recently, American forces stood ready to rush to the aid of Russian submariners.
The Army's current retention rate of 57 percent to 60 percent is evidence of soldiers' morale, noted Rostker, who formerly served as undersecretary of the Army and as an assistant secretary of the Navy. In some cases, he said, the services have had to adjust to the changing role they play in today's missions. The Air Force, for example, adopted the air expeditionary force, which allows it to cycle deployments, and it's "working very well," he said.
Sailors, he pointed out, have always joined the Navy to go to sea. "Six-month deployments for sailors are what they are made of," Rostker said.
He recalled meeting with Army National Guard members training for a rotation in Bosnia. An active duty colonel working with the group told the Pentagon official about the enthusiasm and quality of the National Guard troops.
Playing devil's advocate, Rostker razzed the colonel: "Yeah, but these guys didn't sign up to become the policemen of the world. They didn't sign up to be U.N. soldiers." The colonel stood by his opinion, becoming angrier and angrier, until he realized the Pentagon official was just kidding.
Rostker also recalled meeting an Army sergeant major who was returning to Fort Polk, La., after building and repairing roads damaged by floods in Central America. "He said to me, 'This is the most important thing I've done. This was a lot better than garrison life or going out to the field. This was real.'"
Just as the troops value "real missions," Rostker stressed, DoD values its troops. The department has put substantial resources into improving service members' pay and compensation and other aspects of quality of life.
o A 4.8 percent across-the-board pay increase went into effect in January 2000.
o Targeted pay raises of up to 5.5 percent went into effect for mid-career members in July 2000.
o DoD initiated pay raises greater than the average private sector raises by one-half percent for the next five years.
o A reform of the military retirement system offers members a choice: a return to a system based on 50 percent of basic pay at 20 years of service or a $30,000 bonus at 15 years and a smaller retirement at 20 years.
o A new housing allowance initiative announced in January 2000 is designed to reduce service members' out-of-pocket housing costs to 15 percent by 2001 and to zero by 2005.
DoD officials are also improving military housing, Rostker noted. The Army has "whole base" ventures at Fort Hood, Texas; Fort Lewis, Wash.; and Fort Meade, Md. The Navy recently put $720 million into quality of life programs over the next six years. Other initiatives include:
o Setting a goal to eliminate inadequate family housing by 2010. The Navy and Marine Corps are on track.
o Setting a goal to eliminate gang latrine barracks by 2008. The Air Force has met this goal. The Marine Corps is on track to meet the goal in 2005. The Army and Navy are on track for 2008.
O Setting construction standards to provide more privacy in the barracks and working to improve common areas.
Family programs have been a particular focal point for Defense Secretary William S. Cohen and his predecessor, William J. Perry, Rostker said. Cohen and his wife, Janet Langhart Cohen, recently sparked new momentum in family programs by hosting two forums for service and family members at the Pentagon.
"We've made great strides in taking care of our families," he said. Recent quality of life improvements in family programs include:
o Overall per capita investment in community quality of life programs, including commissaries, schools, recreation facilities, family centers, child care, family advocacy, transition assistance, relocation services and others has increased from about $1,500 per service member in fiscal 1990 to about $2,100 in fiscal 2000, based on 1990 constant dollars.
o DoD has started full-day kindergarten and reduced pupil- teacher ratios in the early grades within DoD dependent schools. DoD has also upped the number of school psychologists and guidance counselors.
o The department has also invested in technology for DoD schools. Their average of one Pentium-class computer for every 4.8 students is well above the national average.
o Over 95 percent of the DoD child development centers are now nationally accredited, compared to 8 percent of the civilian child care centers in the United States. In May, the National Women's Law Center held up the military child care system as a model for nationwide reform.
o DoD has added more than $200 million for morale, welfare and recreation program and physical fitness center improvements. Since 1995, funding for these programs has increased by 19 percent.
"These investments in quality of life are a tangible sign of support for the arduous duty and everyday sacrifices incurred in a military career," Rostker said. "They recognize the important role military families play in achieving overall readiness."


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To track month-to-month trends for sales and inventories of U.S. distributors, jobbers, drop shippers, and import/export merchants, excluding manufacturers' sales branches or offices (MSBOs). Title 13 of the United States Code authorizes the Census Bureau to conduct this survey and provides for voluntary responses.
Companies with employment that are primarily engaged in merchant wholesale trade in the U.S, as defined by the 2007 NAICS, excluding MSBOs. Also excluded are non-merchant wholesalers such as agents, brokers, and electronic markets.
Companies provide data on dollar values of sales and end-of-month inventories.
Monthly since 1946. New samples are drawn approximately every 5 years and are updated quarterly. Use of the latest sample began in Fall 2006.
Data are collected by mail, fax and telephone. Response is voluntary. Questionnaires are mailed each month and request data for the month just ending.
The survey uses a stratified, one-stage design with primary strata defined by industry (e.g., Motor Vehicle and Motor Vehicle Parts, Furniture and Home Furnishings, Grocery, etc.). There are 40 primary strata. The primary strata are substratified into 4, 7, 10, or 13 annual sales size strata. The largest sales size stratum within each industry stratum consists of companies, all of which are selected with certainty (sampling weight equal to one).
The other strata are populated by EINs. Sample sizes are computed to meet multiple coefficient of variation constraints on estimated annual sales and end-of-year inventory totals. Constraints are specified at detailed industry levels and at broad industry levels up to the total wholesale level. Sampling weights range from 1 to 500. Units are selected independently between strata using simple random sampling without replacement within the size substrata. The current sample of 4,400 businesses consists of approximately 1,700 companies and 2,700 EINs. Updates to the sample are made on a quarterly basis to account for new businesses, deaths, and other changes to the universe.
Monthly Wholesale Trade Sales and Inventories reports are released 6 weeks after the close of the data month, containing preliminary current month estimates and final data for the previous month. Statistics include: sales, inventories, and inventory/sales ratios along with standard errors. Estimates are both seasonally adjusted and unadjusted.
An annual benchmark report is released each spring. This report presents the results of the benchmarking operation that revises monthly sales and inventories estimates based on the Annual Wholesale Trade Survey. Estimates are both seasonally adjusted and unadjusted.
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Manufacturers can use inventory estimates as a proxy for the distributors confidence for future expected sales.
Provides a designated principal economic indicator and the only source of current data on wholesale trade.
Business and Professional Classification Survey


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PDF for Lawyers is now part of this site
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During 2004 advances in zoological research of birds and insects increased scientists' understanding of the complexity of biological systems involving brood parasitism, aggression, and thermoregulation. Studies of fish and bats revealed information about the role that ecology and single phenotypic traits (observable properties) could play in the evolutionary divergence that might lead to the formation of species. Through an examination of the fossilized skull of Archaeopteryx, insights were gained into the way flight evolved in the earliest birds. In the field of conservation, two endangered West Indian insectivorous mammals were found to represent the only remaining species of an evolutionary divergence that occurred during the Cretaceous Period. DNA analyses played a prominent role in much of this work.
Brown-headed cowbirds (Molothrus ater) lay their eggs in the nests of birds of different species—a behaviour that is called brood parasitism. The unsuspecting foster parents raise the baby cowbirds as their own. Offspring of some brood parasite species kill host young to ensure for themselves greater resources from attending parents. Likewise, it might appear to be in the baby cowbird's best interests for survival to kill the host birds' offspring, but baby cowbirds seldom do so. Rebecca M. Kilner and Joah R. Madden of the University of Cambridge and Mark E. Hauber of the University of Auckland, N.Z., studied this behaviour with an experiment in which single cowbird eggs were placed in each of 20 nests of the Eastern phoebe (Sayornis phoebe). Once a cowbird egg hatched, the researchers removed the remaining eggs from the nest. In 10 of the nests, they left the cowbird as the only bird in the nest. In the other 10 nests, the researchers introduced two newly hatched phoebes. Therefore, adult phoebes in 10 of the nests were left with a single baby bird (a cowbird) to tend, and in the other 10 nests, the parents were left with three baby birds. Using body weight as a measure of how effectively the baby cowbirds acquired food, the investigators found that cowbirds with two nest mates gained weight more rapidly than cowbirds alone in a nest. By filming the birds in their nests, the researchers discovered that parent birds with three baby birds brought food about 21/2 times more often than those in nests with a single bird. A cowbird in a nest with two phoebes typically took more than half the food the parents brought, so it fared better than the lone cowbirds even though the lone cowbirds got all of the food that was brought to their nests. The study demonstrated that a cowbird's apparent altruism toward baby birds of other species is simply a strategy to get more food.
Female honeybees (Apis mellifera) regulate the temperature of their hives, maintaining it close to 35 °C (95 °F) by fanning their wings for cooling in hot weather and huddling to generate heat from their bodies in cold weather. Honeybees operate as a single superorganism to regulate the temperature inside a hive as the outside temperature rises or falls. Julia C. Jones and colleagues of the University of Sydney, Australia, combined behaviour observations and DNA analyses to demonstrate that the temperature in a hive is more stable and better controlled when the bees are the offspring produced by the mating of the queen with a number of drones rather than with only a single drone. The researchers conducted experiments on pairs of hives having an equal number of bees. One hive had worker bees of mixed genetic parentage (offspring of a single queen and multiple drones), whereas the other housed bees of uniform genetic heritage (offspring of a single queen and a single drone). Worker bees in both hives ultimately maintained an average temperature of 35 °C. In the hive with bees of a mixed genetic makeup, the temperature remained relatively constant, regardless of the outside temperature. In contrast, the temperature in the hive with bees of uniform genetic makeup varied greatly and took longer to regulate than in the genetically diverse hive. The researchers then used DNA tests to confirm the existence of a relationship between genetics and the behaviour of bees of a genetically mixed hive. The tests showed that all the bees that started fanning at a given temperature were more likely to have the same father than those that began fanning at some other temperature. These results suggested that the threshold temperature at which an individual bee begins participating in thermostatic regulation in the hive is genetically based. The bees in a genetically diverse hive are able to keep the temperature more stable because they respond to a broader range of temperatures, some bees beginning the cooling or warming process sooner than others.
Markus Knaden and Rüdiger Wehner of the University of Zürich, Switz., studied aggression in Saharan desert ants (Cataglyphis fortis), which become combative upon encountering ants from colonies other than their own. Desert ants will travel more than 100 m (1 m = 3.3 ft) to gather resources, and as the ant moves away from its nest, its level of aggression decreases. The greater belligerence of the ants in the vicinity of their nest might serve a protective role in guarding the nest of a colony, but the way in which the ants determine their proximity to the nest was unknown. The researchers trained ants to visit a feeding area 20 m from their homes, a distance at which the ants have reduced aggressiveness toward other ants. Ants from four different colonies were captured at the feeding area and then were marked with coloured dots for identification and transported to a distant site. Upon being released at the distant site, the ants immediately began crawling toward their respective nests. Some ants were allowed to travel 20 m toward their nest; others were allowed to travel only a quarter that distance. The investigators then captured the ants again and took them to a laboratory to test their level of aggression. Each ant was paired in a box with an ant from a different colony, and their behaviour was videotaped. Ants that had traveled the 20 m toward their nest were significantly more likely to attack than those that had traveled only the shorter distance. The experiment suggested that the aggressiveness of the Saharan desert ant is based on its perception of the proximity to its home and that the ant does not use sight, smell, or landmarks in determining its location. Instead, some yet-to-be-understood internal means of navigation allows the Saharan desert ant to know how far it has traveled from home.
Tigga Kingston of Boston University and Stephen J. Rossiter of Queen Mary, University of London, showed that the echolocation used by three distinct sizes (morphs) of large-eared hoseshoe bats (Rhinolophus philippinenesis) of Indonesia is accomplished at the same basic frequency of sound but with harmonically distinctive echolocation calls. The different harmonics allow each morph to use echolocation to detect its own suitable prey. The researchers suggested that natural selection for prey-related shifts in echolocation harmonics can lead to related shifts in the sounds used for communication within morphs during mating. These shifts would enhance evolutionary divergence by means of assortative mating (selective mating between individuals in a population) and subsequent reproductive isolation. The investigators showed through DNA analyses that the three morphs have indeed become genetically diverse, while remaining sympatric (occupying the same geographic area).
Studies with three-spined sticklebacks (Gasterosteus aculeatus) by Jeffrey S. McKinnon of the University of Wisconsin at Whitewater and colleagues provided further evidence that evolutionary divergence and reproductive isolation can be caused by only one or a few ecologically significant traits. Sticklebacks make up a species complex that includes two ecotypes—stream-dwelling populations and anadromous populations (populations that live in the ocean and migrate to fresh water to breed). Both types are found across the Northern Hemisphere and are found together, but typically only minor genetic exchange occurs between them. The researchers collected samples of both ecotypes from a variety of locations and maintained them in the laboratory. Anadromous sticklebacks typically grow to a larger size than stream-dwelling sticklebacks, but the investigators controlled the growth of the fish to produce females with a range of body sizes in both types. During experiments the primary factor influencing mating compatibility between females and normal-sized males was similarity in body size, although similar-sized pairs of the same ecotype were slightly more compatible reproductively than similar-sized pairs of different ecotypes. Colour patterns and genetic similarities were not significant factors.
Archaeopteryx, which lived in the Late Jurassic Period, is the epitome of a transitional form on an evolutionary continuum: it possesses teeth characteristic of a reptile but also has feathers, which are characteristic of birds. Although a number of fossils of Archaeopteryx have been discovered and studied, the question remained whether the animal was able to fly. Patricio Domínguez Alonso and colleagues of Complutensian University, Madrid, examined Archaeopteryx fossils with computed tomography, a technique for obtaining cross-sectional images of a solid object by scanning it with X-rays. The investigators found unequivocal evidence of an enlarged forebrain and of optic and auditory systems typical of animals adapted for flight.
Only two species of insectivorous mammals are extant in the West Indies. Both are extremely rare and endangered. One, Solenodon cubanus, is found in Cuba and the other, S. paradoxus, is found on Hispaniola. Alfred L. Roca, Gila Kahila Bar-Gal, and William J. Murphy of the Laboratory of Genomic Diversity, Frederick, Md., and colleagues used DNA gene sequencing to determine that the solenodons diverged from the insectivores, such as shrews, moles, and hedgehogs, during the Cretaceous Period 76 million years ago and that the two species diverged from each other around the time Cuba and Hispaniola split into separate islands, 25 million years ago. The continued existence of both species was being threatened by a variety of human-caused environmental changes, including deforestation and the introduction of predatory species such as dogs, cats, and mongooses. From the perspective of conservation, the findings accentuated the significance of the two species, since they represent a complete phylogenetic lineage that predates the appearance of many present-day orders of mammals.


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Our pals over at Prologue: Pieces of History have "Facial Hair Friday;" here at The Text Message, we give you "Beauty Queen Monday." The document featured in today's post is from the January – February 1960 issue of "The Shield," an employee newsletter published by the International Cooperation Administration (ICA). You can find issues of […]
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Pub Crawl: Knife & Fork Gastropub
: September 26, 2012 : Updated: September 26, 2012 4:48pm
Gloria Allissa Trevino and Brianna Ochoa at Knife and Fork Gastropub.
Front entrance to Knife and Fork Gastropub.
Lizel Sandoval, Mallane Vance, Brandy Riggs, Lance White, Yzenia Stenis, and Megan Thompson are enjoying a game of Jenga at Knife and Fork Gastropub.
Chris and Katie Dupont are celebrating a birthday at Knife and Fork Gastropub.
Eriks De Los Santos and Kira Iles at Knife and Fork Gastropub.
Ryan Kuehl and Josh Slader are watching the game and having a beer at Knife and Fork Gastropub.
Martina Steele and Cody Orozco love working at Knife and Fork Gastropub.
Tony Cortez with 94.1 KTFM is enjoying his birthday cake at Knife and Fork Gastropub.
The bar at Knife and Fork Gastropub.
Address: 20626 Stone Oak Parkway, Suite 103
Hours: Open till 2 a.m. daily; kitchen opens at 4 p.m. weekdays and 11 a.m. on Saturday and Sunday
Phone: 210-497-7111
Web: knifeforkgastropub.com and facebook.com/KnifeForkGastropub
Cost/noise: Medium/ medium
Snapshot: This pub, not bar, is a family operation and dream come true for owners Rudy and Norma Montalvo and chefs Javier Orozco and Gabriel Orozco of Bistro Six food truck. The place is hard to spot from the road, but you'll be happy you found it.
Behind the bar: There's something for everyone. Nearly 20 draft beers are mostly Texas offerings, while house and Wine Down Wednesdays wines are from ONEHOPE, which donates 50 percent of profits to charity. A selection of martinis and cocktails are on the menu. Bottomless mimosas cost $11 during Sunday brunch.
Who goes there: It's a neighborhood hotspot for Stone Oak, but there are some downtown faces in the mix.
Fun and games: Skee-Ball and a variety of arcade games could lead to friendly competition, plus TVs are positioned throughout to keep guests from missing a minute on game day.
Munchies: This is scratch-cooking at its finest, and the food is the main attraction. The menu includes appetizers, such as wings, as well as pizzas, burgers and main dishes of fish 'n' chips, pasta, steak and roasted chicken, just to name a few. Don't forget dessert. Brunch features $5 items, including barbacoa tacos and Big Red.
Soundtrack: Selections can be made via a RoqBot jukebox, so the music varies. Look for live music in the future.
The skinny: Knife & Fork is quickly gaining a loyal following, and the welcoming patio is perfect for cooler nights or Sunday brunch.


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A Russian track star defended her country's repressive laws on pro-equality expression during a press conference and she used an argument that I find extraordinarily annoying. She said, in essence, that we have to "respect" (whatever the hell that means in this context) Russian culture.
ISINBAYEVA: "If we allow [them] to promote and do all this stuff on the street, we are very afraid about our nation because we consider ourselves like normal, standard people. We just live with boys with woman, woman with boys. […]
It's unrespectful [sic] to our country. It's unrespectful [sic] to our citizens because we are Russians. Maybe we are different from European people and other people from different lands. We have our home and everyone has to respect (it). When we arrive to different countries, we try to follow their rules.
No, no, no. I don't have to "respect" (again, no idea what that could possibly mean here. Stop criticizing? Agree with?) oppressive laws in Russian any more than I have to respect them in my own country just because a majority might support them. Oppressive laws are wrong no matter what country they occur in.


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Method and apparatus for treatment and post-treatment of the stenosed region of an artery after reduction of the region by angioplasty or other means by applying a radioactive dose to said reduced region of the artery by positioning a radioactive dose to the reduced region is disclosed.
1. A method for treatment and post-treatment of a stenosed area of an artery comprising the steps of:
reducing the annular stenosed area within an artery;
advancing a radioactive dose means within the artery to the area of reduced stenosis, the radioactive dose means being operatively connected to positioning means and the advancing step being performed by moving the positioning means;
applying a radioactive dose to the area of reduced stenosis by exposing the area of reduced stenosis to the radioactive dose means; and
removing the dose means from the artery by moving the positioning means.
2. A method as defined in claim 1 wherein the step of applying the radioactive dose is sufficient to affect smooth muscle cells within the area of reduced stenosis to inhibit rapid growth of such cells, thereby preventing restenosis of the artery.
3. A method as defined in claim 1 further including a step of continuing to reduce the annular stenosed area while applying a radioactive dose to said area.
4. A method as defined in claim 1 including a step of allowing blood flow through the area of reduced stenosis while applying the radioactive dose.
5. A method as defined in claim 1 including the contacting of the tissue of the area of reduced stenosis with the radioactive dose.
6. A method as defined in claim 1 further including a step of containing a source of radioactive dose before and after exposure to said area of reduced stenosis.
This invention relates generally to angioplasty and more particularly to a method and apparatus for preventing restenosis after angioplasty or other stenosis treatment.
In the past, catheters have been developed which may be effectively inserted into blood vessels and maneuvered through a vascular tree. A balloon may be used with such catheters to expand in the vessel and open blockages found therein. In a typical percutaneous transluminal coronary angioplasty (PTCA) or percutaneous transluminal angioplasty (PTA) procedure, a guiding catheter is percutaneously introduced into the vascular system of a patient through an artery and advanced therein until the distal tip of the guiding catheter is appropriately positioned. A dilation catheter having a balloon on the distal end thereof and a guide wire are slidably disposed and introduced through the guiding catheter. The guide wire is first advanced through the distal tip of the guiding catheter until the distal end of the guide wire crosses the lesion to be dilated. The dilation catheter is then advanced over the previously introduced guide wire until the dilation balloon on the distal extremity of the dilation catheter is properly positioned inside the lesion. The balloon portion of the dilation catheter is then inflated to a predetermined size to radially compress the atherosclerotic plaque of the lesion against the inside of the artery wall to thereby reduce the annular stenosed area. After a period of time, the balloon is deflated so that blood flow is resumed, allowing the dilation catheter to be removed.
A major problem encountered in a significant number of patients treated by this procedure is the subsequent narrowing of the artery after the expansion treatment. Various methods and apparatus have been developed to address the restenosis problem including multiple inflations of the balloon during the original procedure, atherectomy, hot balloons, and lasers. Even the installation of permanent stents has been thought to potentially have some value in reducing restenosis rates. See, for example, U.S. Pat. No. 5,019,075 to Spears et al. wherein the region surrounding the balloon utilized in the angioplasty procedure is heated by means within the balloon, or within the skin of the balloon, upon inflation of the balloon in order to ideally fuse together fragmented segments of tissue. U.S. Pat. No. 4,733,655 to Palmaz discloses an expansible vascular graft which is expanded within a blood vessel by an angioplasty balloon to dilate and expand the lumen of the blood vessel. The Palmaz method and apparatus leaves the expandable vascular graft in place to ideally prevent recurrence of stenosis in the body passageway.
However, recent data seems to indicate that the prior art methods described above do not significantly reduce restenosis rates of occurrence. In restenosis, a proliferation of cells following angioplasty is believed to cause the lesion to reform. The rate of occurrence of restenosis is generally considered to be about 33 percent. It would therefore be desirable to have a method and apparatus to treat a lesion in order to reduce the restenosis rate of occurrence. The present invention is believed to provide a unique method and apparatus to reduce the restenosis rate of occurrence following an angioplasty or like-intended procedure.
The purpose of the invention is to provide method and apparatus to significantly reduce restenosis rates of occurrence following an angioplasty procedure. To accomplish this purpose, there is provided method and apparatus for exposing the dilated lesion to a radiation dose that will affect smooth muscle cell growth. There is provided a catheter which has at its distal end a radioactive source, the source being maneuverable to the site of a lesion which has been dilated or removed, the apparatus allowing the site to be exposed to the radiation dose that will affect smooth muscle cells such that the rapid growth of such cells can be prevented, thereby controlling restenosis.
In one aspect of the invention there is provided a method for treatment and post-treatment of the stenosed region of an artery comprising the steps of:
reducing the annular stenosed area within an artery; and
applying a radioactive dose to the area of reduced stenosis.
In another aspect of the invention there is provided a method for treatment and post-treatment of the stenosed region of an artery after reduction of said region by angioplasty or other means comprising the step of applying a radioactive dose to said reduced region of the artery.
In yet another aspect of the invention there is provided apparatus for post-treatment of a stenosed region of an artery that has been reduced by angioplasty or other means comprising:
radioactive dose means; and
positioning means operatively connected to said dose means to position said dose means within the stenosed region of an artery that has been reduced by angioplasty or other means.
FIG. 1 is a partial cross-sectional view of an embodiment of the invention wherein said dose applying means is a radioactive element contained within a wire wound housing for radioactive containment, the housing having a window cut-out. A larger wire wound sheath covers the window during insertion and removal, the sheath being withdrawn to expose the radioactive element at the lesion site.
FIG. 2 is a partial perspective view of an alternate embodiment having a radioactive dose means positioned upon the balloon of an expandable balloon catheter, said balloon catheter being provided with a means or perfusion to allow blood flow during the time the balloon is inflated.
FIG. 3 is an enlarged partial cross-sectional view of a portion of the apparatus shown in FIG. 2.
FIG. 4 is a partial perspective view of the apparatus shown in FIGS. 2 and 3 upon expansion of the balloon portion of the apparatus.
FIG. 5 is a partial perspective view of another embodiment of the invention wherein the radioactive dose means is an element that may be contained within a complementary containment means provided with a remotely actuated window.
FIG. 6 is a partial perspective cross-sectional view of a catheter tip containing radioactive dose means showing the remotely actuated window.
FIG. 7 is a partial perspective cross-sectional view of an alternate embodiment further including a stent wherein said radioactive dose means is in the form of a coating of radioactive material on the stent.
FIG. 8 is a partial cross-sectional view of the device shown in FIG. 7 after expansion of the stent shown in FIG. 7.
FIG. 9 is a partial perspective view of the stent illustrated in FIGS. 7 and 8 wherein the stent is implanted within the artery.
With continued reference to the drawing, FIG. 1 illustrates the apparatus and method for preventing restenosis of an artery that has been enlarged by angioplasty or other procedure. Specifically, apparatus, shown generally at 10, is positioned within artery segment 12 having lesion site 14 which has previously been enlarged by angioplasty or other procedure such that atherosclerotic plaque 16 has been radially compressed by expansion of the balloon portion of an angioplasty device (not shown) or removed by other means. Device 10 having distal end 18 with tip 20 and wire wound housing 22 is positioned such that housing 22 is positioned within the lesion site 14. Housing 22 contains radioactive dose means 30 and is provided with window cut-out 32. Device 10 includes a wire wound retractable sheath 24 and catheter shaft 26 with guide wire and guide wire port 28. A radioactive dose means 30 is moveable by advancing or retracting catheter shaft 26 which may be referred to as a positioning means. Sheath 24 is drawn back when the radioactive dose means is positioned directly proximate the lesion site 14 such that window cut-out 32 is opened to expose the lesion site 14, which has been previously dilated, to a radiation dose that will affect the smooth muscle cells/plaque.
In FIG. 2 there is illustrated a device shown generally at 34 which is an alternate embodiment of the invention further including an angioplasty balloon 36 with dose means in the form of radioactive elements 38 attached thereto. Device 34 includes catheter shaft 40 having perfusion capabilities provided by holes 41 positioned proximately and distally to the balloon portion.
FIG. 3 shows in expanded view details of balloon 36 of FIG. 2 positioned about catheter shaft 40 having two main lumens 42 and 44. Lumen 42 makes provision for guide wire capability and contains perfusion holes. Lumen 44 is the lumen which provides the passage to inflate the balloon from the inflation port 45 shown in FIG. 2 at the proximal end of the device 34. The radioactive elements 38 are not shown in FIG. 3.
FIG. 4 illustrates the device 34 of FIGS. 2 and 3 wherein the balloon 36 is expanded in the vicinity of the lesion site 46, and the radioactive elements 38 are forced into contact with the lesion.
It is understood that the various embodiments of the subject invention are useful in the treatment of a lesion site within an artery. "Lesion site" includes those lesions which have been treated with balloon angioplasty, those lesions that have been treated by an atherectomy or laser angioplasty, those lesions that have been treated by rotational atherectomy or any other means of compressing or removing the material of the lesion which may cause trauma to the artery. It is this trauma which causes the proliferation of smooth muscle cells which method and apparatus of the subject invention is intended to inhibit.
With regard to all embodiments of the subject invention, "radioactive dose" means bombardment by particles emitted from radioactive materials including, but not limited to, materials such as Radon 222, Gold 198, Strontium 90, Radium 192, and Iodine 125. These materials may be incorporated into or delivered in a solid, liquid, or gaseous form, and the delivery of such forms is considered to be within the scope of the subject invention.
FIG. 5 illustrates an alternate embodiment of the subject invention in the form of apparatus shown generally at 48. Sheath 50 of said device is preferably made from a helically wire wound member to provide a measure of shielding for the radioactive dose means. Device 48 includes positioning means 52 which is a motion wire providing slidable motion of the radioactive dose means 54 within the sheath. Radioactive dose means 54 is thus positionable proximate to the lesion site 56 of artery segment 58 and retractable within sheath 50 for insertion and removal within the artery segment 58.
FIG. 6 illustrates yet another embodiment of the subject invention in the form of the device shown generally at 60, similar to the device 10 shown in FIG. 1. In FIG. 6, device 60 is comprised of the shaft portion 62 and contains at its distal end a canister 64 containing the radioactive dose means. This canister 64 has a remotely actuated window 66 which can be actuated through port 68 to expose the radioactive dose means to the lesion 70.
FIGS. 7, 8, and 9 illustrate yet another embodiment of the subject invention wherein a device shown generally at 72 is an inflatable stent delivery balloon system for delivery and expansion of stent 74. Stent 74 may be removable or may be a permanent implant. In the case of a permanently implanted stent, the radioactive dose means has to be carefully chosen in terms of dose level and half-life in order to limit the total radiation dose. In this embodiment, the radioactive dose means is associated with stent 74 and may be included as a cladding, a coating, an additive within the basic stent material itself, or an attachment by other means to the stent. In FIG. 7 the device 72 includes an inflatable balloon dilation catheter to position stent 74 within lesion 76.
FIG. 8 shows the expanded balloon of the stent delivery system 78 having dilated stent 74 in close proximal contact with lesion 76.
FIG. 9 shows the stent 74 in place within lesion 76 with the stent delivery system having been removed from the artery.
The foregoing description of the drawing illustrates various methods of the invention. It should be understood that the methods of the invention include the treatment and post-treatment of an annularly stenosed region of an artery. Most methods of treatment currently available cause some trauma to the artery. The artery in response to this trauma proliferates the growth of smooth muscle cells in many cases, and this results in restenosis at the site of the original stenosis--usually within a six-month period. The post-treatment consists of exposing the treated region of the stenosis to a radiation dose which is sufficient to retard or halt the proliferation of smooth muscle cells. It should also be pointed out that both the treatment and post-treatment could occur simultaneously if the device which removes or compresses the stenosis material also contains the radioactive dose means.
Having indicated above preferred embodiments of the present invention, it will occur to those skilled in the art that modification and alternatives can be practiced within the spirit of the invention. It is accordingly intended to define the scope of the invention only as indicated in the following claims.
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Gear Review
Runnin' with the Devil!!
I picked up these (& the matching jersey) off Bonktown.....totally money well spent. The sizing is very true to fit. I am 5'10" 195ish, size 34 in most jeans and a large (top & bottom) fit perfectly. The guy I live chatted with totally knew what he was talking about for sizing!!
The legs are a bit longer than my Campagnolo bibs which I totally dig. I put 20 miles on them the day after I got them and there was no leg ride-up and the straps were unnoticeable. The chamois is a perfect thickness for all-day saddle comfort. The white leg panels are a bit transparent up close but nothing major. The only thing I miss is a radio pocket for my iPod....but not worth dropping a star for it.
Killer bibs at a killer BT price!!!
View More Details on Hincapie Sportswear Legado Collection Diablo Bib Shorts


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The Massaging 3-in-1 Butterfly Pillow has an innovative "hinge" design that opens and closes to solve multiple support problems. Use it closed to support and align the legs and lower body. Use it open to cradle your thighs, calves or heels. Or, flip on the massage switch to use it as a vibration massager in any position. Soft, comfortable memory foam molds to provide a custom fit. Includes a velour cover that removes for machine washing.
See more details
Item # 202075
Buy the Massaging 3-in-1 Butterfly Pillow at SharperImage.com. It has an innovative "hinge" design that opens and closes to solve multiple support problems.
• Hinge design opens and closes for different types of support
• Closed position aligns lower body
• Open position elevates and cradles legs and calves
• Optional vibration massage function works in any position
• Made of soft, comfortable memory foam
• Includes removable, washable cover
• Requires 4 AA batteries
PLEASE NOTE: This is a personal care item and is returnable if in its original unopened packaging and unused condition.
Length: 12
Width: 8.5
Height: 7.6
Weight: 3 Lbs
Our Price: $39.99
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Links to checklists, guides, presentations, references, and tip sheets for growers and Extension agents.
1. Grape Grower's Checklist: a step-by-step guide for new grape growers in Virginia. more >>
2. Recommended Publications
3. eViticulture : A national viticulture extension resource.
4. East Coast Viticultural Suitability Investigative Tool : This web application is used to display maps and utilize geoprocessing tools built for the USDA-SCRI funded project, "Improved grape and wine quality in a challenging environment: An eastern US model for sustainability and economic vitality."
5. Extension Presentations: PowerPoint presentations from previous industry meetings. more >>
6. Compost Use in the Vineyard
7. : contact information of recommended nurseries in the United States and Canada.
8. Dormant Grapevine Pruning: Adobe Presenter presentations. Get Flash Player to view.
9. Grapevine Petiole Sampling Instructions
10. Grape Pest Management
Virginia Grape and Wine Organizations
Out-of-State Organizations


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12 of Our Favorite Food Movies
How about a list of favorite food scenes in movies? Many have been mentioned already like the famous one in Tom Jones and 5 Easy Pieces... I found some great ones here: http://talkingoffood.com/movie-clips.html
How about a list of favorite food scenes in movies? Many have been mentioned already like the famous one in Tom Jones and 5 Easy Pieces... I found some great ones here: http://talkingoffood.com/movie-clips.html
I think Bill Sewell's 'Food from the Place Below' is still available on Amazon. Not new, but best, tastiest vegetarian dishes ever!
Like @nycpunk1 I've found great places by asking taxi drivers, but you have to have a good command of a language in common to weed out the tourist traps and to persuade them that you really do want to eat where they do :)
I've also had great recommendations from SE when I'm in US. Wish I could find something as good for my native UK.
Thanks to all of you for your recommendations. Keep them coming! I'll let you know which ones I managed to get to.
You can see lamian (hand-pulled) and daoxiao mian (shaved) being made here:
Christmas 20 some odd years ago...
In the kitchen, an over-generous friend poured a whole glass of brandy over the pudding and lit it as I was carrying it to the table. Only trouble was, miles of corridor before I could put the dish down and flaming brandy slurping over the edge onto my wrist. I made it to the table - just. Ice water, bandages and pain, but no scar!
Thanks so much. I've ended up at Zabar's (nearest) but will remember to try Westside and Fairway next trip.
I forgot to mention the wonderfully witty Lady Agnes Jekyll's 'Kitchen Essays'. She was a great society hostess who wrote food articles for The Times around the turn of the last century. I found a couple of audio readings here:
"Toast" by Nigel Slater is a wonderful picture of childhood and growing up in 1960s England told through food memories. I don't know if he's known in the US but he's a very popular food writer in UK.
Here's a video about Gongfu cha and Tieguanyin tea from Xiamen in China. It shows what Barry Foy talks about above.. http://www.talkingoffood.com/watch/1-video-content/23-tieguanyin-tea.html
Some hae meat and canna eat
And some wad eat that want it,
But we hae meat and we can eat
And sae the Lord b thankit.
Robert Burns
I eat mussels equally in England and New Zealand (far-flung family) and I've been trying to figure out the common ground between the small, intensely coloured and flavored ones from the north and the huge, soft, pale green-lipped southerners. Sweetness, softness combined with a bit of chew, and the merest hint of ocean. Actually, I think LunaPierCook's probably said it all.
Judith klinger - fennel and rum? is that fennel bulb, flower, seed??
I can only drink coffee before noon without suffering - rooibos tea is the answer. Let it brew for at least 4 minutes (or more) and you'll never notice the lack of caffeine.. loads of health benifits, antioxidants etc. but it taste great.
almond butter and dill pickle I would never have thought of - can't wait to try
This is 100% entertainment. Thanks, Adam.
Cold roast potatoes - if I'm lucky enough to have some in the fridge. Otherwise I second the cornflakes and milk option.
Jules, your cold roast chicken and mayo baguette is even better than my Christmas leftovers. Totally sublime!
Definitely leftover Christmas dinner (would that be Thanksgiving dinner in the US?). Bubble and squeak made with leftover roast spuds, veg and (essential) bread sauce, served with cold turkey and chestnut stuffing - knocks spots off the original hot meal. Cheers from your greatest UK fan!
Thanks, BaHa. I look forward to my first ballgame - but will probably pass on the Crackerjack!
As an English reader who's never been to a baseball game (yet!), I've never heard of Crackerjack. Could someone explain?
Perfectly balanced video - just like the cheese and wine - Joshua Wesson's got it just right. More!
How about that dinner in Soylent Green where they find some real wine and meat? No. 1 for me is Babette's Feast though.
I've finally managed to get a 6 day stop in San Francisco on my way from London to New Zealand! Working and staying the first few days in the Fairmont Hotel then staying with friends in Oakland. Any recommendations for places to eat would be so appreciated. Simple and delicious is what we're looking for!
Last night in New York tomorrow and I'm having some friends over for dinner in a rented apartment. Too much to do for serious cooking so where would you recommend for good prepared food and what dishes in particular? Upper West Side preferably but willing to travel!
For me it's papaya and lime, bacon and mushrooms. These are combinations that are so much more than the sum of their parts that they're inextricably linked. What are yours?
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Trendy Best Zen Cart Template 29256
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Trendy luggage and handbag store template with a two column white content area that features various designer hand bags. There is a star covered black background behind the centered content area. The logo says Trendy in white thin lettering and can be customized. Trendy Best Zen Cart Template 29256 has a width of 1735 pixels and is available in the following sources: .PSD, and .PHP. Software required includes Winzip 9+ (Windows) or Stuffit Expander 10+ (Mac) for uncompressing .zip files, Adobe Photoshop CS+, Adobe Dreamweaver 8+ (or any php-editor), PHP 4.3.2 or higher (PHP 4.4.x for optimal performance), Apache 1.3.x and MySQL 3.2.x or higher, and Zen Cart 1.3.9 only. It has had a total of total of 4 downloads since it first appeared.


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A 1972 Rolls Royce Silver Shadow with the long wheel base. The long wheel base variant, some 4" longer was to provide additional rear... More


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Journey to Center
- Thomas Crum
- Fireside Books (1997)
- 222 pages
- Aikido / Philosophical
Book Summary:
Using anecdotes from his own journeys and from the extraordinary people he's met around the world, Thomas Crum introduces the principle of centering, a skill for unifying body, mind and spirit. Centering enhances performance in sports --- from the quality of your golf game to skiing particularly difficult terrain --- results in greater productivity and power at the office, and allows you to let go of stress and insecurities in order to enjoy harmonious relationships. With specific exercises and detailed information on applying centering to all areas of life, this book provides a step-by-step guide to this unique skill for improving yourself and your life.
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