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5.0 out of 5 stars A great addition!
This is a great addition to the aurora teagarden series!
After the somewhat depressing A Fool and his Honey, Aurora
is back and better than ever!
Roe has spent the last year in a daze after being widowed.
But now she finds out a company is making a movie based on the
first set of murders she was involved with so long ago.(Real
Published on Sept. 8 2002 by elizabeth
3.0 out of 5 stars Roe is back, and it's good to see her
Charlaine Harris is an interesting mystery writer, in part because she is willing to take chances in her books. In Roe's last outing, A Fool and His Honey, an abrupt death near the end of the book brings the reader up short. We are not used to having sympathetic, continuing characters die in mystery fiction.
But, of course, life is like that.
In this outing,...
Published on March 18 2003 by Booked4Life
Most Helpful First | Newest First
5.0 out of 5 stars A great addition!,
elizabeth (quad cities, IL USA) - See all my reviews
This is a great addition to the aurora teagarden series!
After the somewhat depressing A Fool and his Honey, Aurora
is back and better than ever!
Roe has spent the last year in a daze after being widowed.
But now she finds out a company is making a movie based on the
first set of murders she was involved with so long ago.(Real
Murders, 1990)Along with the production company, her old almost-
flame, Robin Crusoe returns. He is the author of the book their
movie is based on.
The chemistry between Roe and Robin is fabulously written. I
found myself easily adapting to the idea of Robin, and Harris does a great job of showing Roe's turmoil about this new relationship and her feelings for her deceased husband.
The plot is enjoyable, blending many of the previous secondary
characters readers have been fond of. The Murder itself is not
as all inclusive as some of the others in the series, but Harris does a great job of drawing the readers back into the series after the depressing A Fool and his Honey.
I strongly recommend reading this book, but I suggest that if you are new to the series you begin back at Real Murders and work your way into this book. Either way is enjoyable, but you will really appreciate the characters more if you have followed them in the series.
5.0 out of 5 stars Terrific Teagarden ale,
Harriet Klausner - See all my reviews
It has been over a year since Aurora "Roe" Teagarden's husband has been murdered but the Lawrenceton, Georgia librarian is still in deep mourning. She is not at all happy that a Hollywood crew is coming to town to shoot the scenes from "Whimsical Death" based on the first homicide Roe ever solved. Also coming to town is Robin Crusoe, Roe's ex-boyfriend, and the person who helped her solve the case but subsequently went on to write the book on their investigation that has led to the movie.
Roe is also unhappy that her stepson Barrett is starring in the movie because they despise each other. When Robin hits town, old sparks ignite and Roe begins to realize that the movie filming might be a blessing in disguise. What Roe doesn't know is that there is a murderer amongst the Hollywood set. This person plans to kill the movie's star and target Roe as his next victim.
Fans of the Aurora Teagarden series will like the way the heroine displays her grief while moving on with her life. Readers will delight with the appearance of a new man in Roe's life, one that is different than her deceased husband. It is very easy to see why Robin and Roe click. The story line is fast-paced, well plotted, and exciting with enough twists and turns to keep readers on full alert.
Harriet Klausner
4.0 out of 5 stars Roe's getting back on the track...,
Susan Shedd (East Calais, VT USA) - See all my reviews
and it's typical that it needed a murder to rouse her. This series seems to have recovered a little of the light-heartedness that had dimmed over the last few books, but it is NOT (despite idiot jacket blurbs) a "cozy."
The plot is thinner than is typical in a Harris mystery -- mostly, I think,so readers can get to know the "new" Roe -- a woman who was widowed with shocking suddenness as an almost incidental incident in a series of nasty crimes. Harris does an excellent job with Roe's gradual recovery, though she focuses exclusively on Martin Bartell's death and ignores the trauma and misery that must have resulted from the attendant crimes. And what would be sufficient to distract Aurora Teagarden in her half-frozen state? Murders old and new, of course.
The movies are coming to town, and they are filming a script based on a true-crime book dealing with a horrid series of murders that plagued Lawrenceton many years earlier. Roe had been instrumental in exposing the killers in that case (nearly dying herself in the process). Roe is NOT happy about this movie, which tastelessly commercializes the deaths of people she knew and cared about, but the rest of the town is star struck. The movie provides an excellent vehichle for bringing Roe's sullen and immature stepson, Barrett, and her one-time, almost-boyfriend, Robin (author of the true crime book), back to town.
However, the movie set is not where Roe finds important information about the new crimes in Lawrenceton. It's her library's collection that holds some of the keys to the mysteries. The murder itself has a fairly wispy plot with not much of anything to detect; the associated crimes are somewhat more melodramatic.
If you've been reading this series, you'll enjoy the development of several long-time characters, as well as Roe's deepening relationship with her mother. This book does a great job in setting up the next one, and it is absorbing to read. If you are new to the series, though, do NOT read this one first. It doesn't quite stand alone.
5.0 out of 5 stars Depression over? Thank God!,
By A Customer
It's was nice to read that Harris was back on track in this latest installment of the Aurora Teagarden Mysteries.
Roe is getting on with her life after her husband's death. Although she is not getting out much and is mostly concentrating on her job and home, things change when action comes to town. Robin returns when one of his books, based on Roe, has been turned into a movie and the entire production crew arrives to film. At first Roe is put off when all her friends find some place in the movie, either stunt work or leasing the church for filming, but gets over it when her once upon a time romance with Robin begins to heat up again. (Excuse me, but are those books your shelving or are you just happy to see me?)Of course it wouldn't be a mystery without a little murder. When the leading lady turns up dead, it's up to Roe to find out Who Dune It.
5.0 out of 5 stars Better and better,
James "jtxjee" (Texas) - See all my reviews
The Aurora Teagarden series keeps getting better with each installment. Charlaine Harris seems to keep her characters fresh and exciting. They are believable people who might live in your neighborhood. The problems are real, the emotions human. Life is lived between books so there is always something to catch up on. Roe, her coworkers, and friends seem to be real, breathing people who solve their problems in real ways. The storyline is just as important as the characters, and this story will not disappoint. It allows the reader to learn about some new area of interest while enjoying a series that keeps the reader coming back for more. If only the author could write faster...
3.0 out of 5 stars Roe is back, and it's good to see her,
Booked4Life "booked4life" (middle america) - See all my reviews
Charlaine Harris is an interesting mystery writer, in part because she is willing to take chances in her books. In Roe's last outing, A Fool and His Honey, an abrupt death near the end of the book brings the reader up short. We are not used to having sympathetic, continuing characters die in mystery fiction.
But, of course, life is like that.
In this outing, the mystery situation is pretty farfetched, but Harris makes it enjoyable, by bringing us along as Roe Teagarden re-enters her life following the death of her beloved husband.
A fast, fun read, but not the best of the series. Still--worth your time.
5.0 out of 5 stars Very good,
This book was in perfect condition and arrived very fast. Nothing negative to say about it. I bought the 8 books of the serie and they were all new. Very good, and very satisfied!
3.0 out of 5 stars so so,
This review is from: Last Scene Alive: An Aurora Teagarden Mystery (Kindle Edition)
Good but enjoyed the other Aurora Teagarden books better. Enjoyed the fact that it had reintroduced some older characters back into the plot
5.0 out of 5 stars Charlaine Harris.,
Can as expected but faster than anticipated.
0 of 3 people found the following review helpful
1.0 out of 5 stars Last Scene Alive,
By A Customer
This new series is to awful for words.
Most Helpful First | Newest First
Last Scene Alive by Charlaine Harris (Hardcover - June 2003)
Used & New from: CDN$ 141.63


text:
Click here for statistics from the 2012 admissions round (2013 entry)
Key points:
- 1468 people applied; just over 10% received offers. This figure is skewed slightly upwards by the 255 international, fee-paying candidates (only 1 received an eventual offer), but irrespective of this, competition for places remained stiff.
- The mean BMAT score was 52% (down from 55% in 2011); this rose for to those short-listed to 62% (66% in 2011). For those with an offer of a place, the mean adjusted BMAT score was 65% (68% in 2011) .
- The mean number of total GCSE qualifications offered (not including short courses and other GCSE-equivalent qualifications) was 10.5.
- The mean proportion of A* at GCSE was 0.80 (0.76 in 2011); this rose for those short-listed to 0.94 (0.90 in 2011). For those with an offer of a place who had taken GCSEs, the mean proportion of A* at GCSE was 0.94 (0.91 in 2011).
- BMAT is the only element of an application that is common to all applicants for Medicine and giving as it does a snapshot of ability and aptitude, is an important selection tool when assessing a large number of extremely well qualified applicants.
Our analysis:
- Every year, the standard is higher and the competition is tougher: almost 95% of GCSEs at A* and an average of 65% at BMAT for successful candidates are both hugely impressive results.
- The slight reduction in BMAT score from last year's 68% is scant comfort; candidates still need to perform very strongly in the BMAT to stand a good chance of getting it
- Thorough preparation is your best chance of doing well and impressing short-listers.
GeMS offers courses on both general medical school applications and specific BMAT preparation

subset: commoncrawl


text:
It's a new year and a new chance to improve your survival skills. Here are ten skills every disaster prepper should keep well honed.
1. A Positive, Practical Attitude! It may sound corny, but positive thinking really can make the difference in an emergency situation. Panic is your enemy. There are many rules that survivalists use to stay focused in tough moments. For instance the "Rule of 3s" states that a person can live for 3 minutes without air, 3 hours without body temperature regulation (shelter), 3 days without water, and 3 weeks without food. This makes it easy to see that shelter is a must-have in an emergency situation. Another rule: SPEAR, short for Stop, Plan, Execute, Assess, and Re-evaluate. This rule of thumb can help you stay confident and focused in the face of a survival situation.
2. Building a Fire. A survivalist should be able to build a fire with matches or butane lighter. More advanced survival experts should be able to use flint and steel, bow-drill, fire saw, and other friction-based methods. Practice lighting a fire when it's windy or rainy, to make sure you can also do this in the wild.
3. Identifying Edible Native Plants. If you're stuck in the wilderness for an extended period, knowledge of local flora could save your life. Many edibles, such as cattails and oak acorns, are common across North America. A dedicated survivalist sets aside time to study edible plants as well as deadly look alike species.
4. Collecting Water. Survivalists should know how to collect potable water, even in desert environs. Can you build a solar sill or rain catch? If not, brush up so that you can obtain water even in dire circumstances.
5. Signaling Methods. From flashing a mirror to building a smoky signal fire to creating ground-to-air messages, the survivalist has many different signaling methods at his or her disposal. Check your knowledge and toolkit to make sure you're prepared to catch rescuers' attention, should you become lost on your next outdoor adventure.
6. Cartography and Orientation. If you're a backcountry enthusiast, you know the importance of finding your way in the landscape. A savvy survivalist should be able to determine his or her current location using terrain features, a compass, and a map.
7. Building Shelter. Most wilderness survival courses prioritize shelter building as a top survival skill. As a minimum, the survivalist should carry a tarp and ropes, which may be configured into several different types of quick field shelters.
8. Purifying Water. In many natural settings, free-flowing water is bountiful, but tainted with gut-wrenching bacteria. To survive an emergency, people need about a gallon of water per day. Study how to purify water using filtering pumps and iodine tablets, and make sure that your purifying gear is in good shape going into the backpacking season.
9. First Aid Response. Snakebites, broken bones, intense indigestion—all of these maladies and many more are possible in a survival situation. Smart survivalists educate themselves on how to deal with food poisoning, how to stop bleeding, how to handle shock, and many other common first aid situations. Hypothermia and hyperthermia are survival first aid subtopics that demand their own attention.
10. Catching Your Dinner. The hunter or fisherman is infinitely better equipped for survival than the greenhorn. Strong survival skills include the ability to build and setting traps, catch fish, and take down game. And you'll need to be able to clean, cook, and preserve what you catch in the wild as well.
These skills aren't just for the outdoor enthusiast; they're also for those who hope to survive natural disasters.
[photo by: mynameisharsha on Flickr via CC License]
Tags: survival, Survivalist


text:
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text: Authentication is the process of determining whether someone or something is, in fact, who or what it is declared to be - the act of confirming the truth of an attribute of a datum or entity. This might involve confirming the identity of a person or software program, tracing the origins of an artifact, or ensuring that a product is what its packaging and labeling claims to be. Authentication often involves verifying the validity of at least one form of identification.


text:
- archive
- New Careers Podcast: Louis Stupple Harris.
- "quite simply the best"
- Responsible Innovation Article
- STS Summer Internships
- STS Research behind EPSRC Statement
- New book: Presocratics and the Supernatural
- Sleepwalking in Middle Ages
- UK citizen views on carbon capture and storage: new study
- PlosOne for Stilgoe: new paper
- MSc prize winner
- STS Alumnus Publishes Policy Report
- Prize winning dissertation
- Material Histories of Chemistry
- Light and Dark
- Emotions, Transformations, Restorations
- New paper: Helmholtz Club, Neuroscience and Francis Crick
- New scholarship for PhD studies
- STS PHD students shine
- Notes for brewing genius
- STS Goes Dutch
- Vacancy: Project Co-ordinator
- New Careers Podcasts
- Why should we promote public engagement with science?
- New Paper: The Science of Destruction:
- UCL Donors help fund a forgotten treatment for TB
- PhD Studentship: Making the Oceans Visible
- STS Prof in award-winning book
- Vacancy: Lecturer in Science Communication
- STS Prof Hits 4 Million
- Vacancy: Lecturer in Science & Technology Studies
- PhD Conference Review. September - January.
- 8th London Ancient Science Conference
- STS explores science on a pagan planet
- Wonderments of the Cosmos
- STS Trip! War Rooms & Banquetting House
- Emotions, Transformations, Restorations
- New paper: Harvey, Aristotle, Astrology
- Students notice excellence
- STS Research Day 2014
- The Closed Loop
- Awe Fear and Fireworks
- Undergraduate Prizes 2014
- Two STS staff promoted
- Farewell Jo Pearson
- Prof Agar on Science and WW1
- Brian Balmer speaks at UN
- NSS2014 - STS scores 100 percent (again)
- STS takes on Latin America (part 1)
- European funding success
- Upcoming Event: Perspectives On Neglected Tropical Diseases
- STS PhD students shine in South America
- Honorary degree for STS leader
- Student Success For Grand Challenge Pitch
- First STS Haldane Lecture Announced
- STS Seminars Confirmed
- Eugenics at UCL: We inherited Galton
- A Clichéd History of Computing
- STS PhD student on the BBC Breakfast Show
- Fireworks, with Simon Werrett
- RRI in Rome
- CFP: Philosophy of Information workshop
- STS's Stilgoe speaks to Parliament
- STS research seminars Term 2 announced
- Prof Frank James elected
- Students Organise BSHS Postgraduate Conference 2015
- Science Communication Careers Event for STS Students
- Student article on science funding
- New book: Politics of Geoengineering
- Toxic World
- London Ancient Science Conference
- STS Invited to the UN in Geneva
- STS PGTAs Shine at the Teaching and Learning Conference 2015
- STS workshop on "scale" is big success
- Fully-funded PhD Studentship
- STS staff speak at the WHO
- Newton on the Eye
- An Evening with the Planets
- Restaging Chemistry
- call for papers: Technology, Environment and Modern Britain
UCL Department of Science and Technology Studies is an interdisciplinary centre for the integrated study of science's history, philosophy, sociology, communication and policy, located in the heart of London. Founded in 1921. Award winning for teaching and research, plus for our public engagement programme. Rated as outstanding by students at every level.
At UCL, the academic mission is paramount. Our ambition is to achieve the highest standards in our teaching and research.
Join us for BSc, MSc, and PhD study.
Staff books include:
Farewell Jo Pearson
28 July 2014
STS announces the departure of Ms Jo Pearson, our academic administrator. She is taking up a post elsewhere in UCL, in Department of Medical Physics and biomedical Engineering. Jo joined STS in January 2009. She leaves STS at the end of August 2014.
First, congratulations to Jo on her new appointment. This is a further step up the professional services ladder. Jo will help them build. Very best of luck in that post.
Second, it goes without saying this is sad news for STS. Jo has become an important pillar in the department. We have depended on her in uncountable ways. She has added value across a wide range of our activities, and she's made STS a better department. I think I can speak for everyone in saying that Jo is going to be missed, and we're all that little bit better because she's been here.
Best of luck from all of STS, Jo.
Prof Joe Cain, Head of Deaprtment
Page last modified on 28 jul 14 17:36 by Joe Cain
UCL Department of Science and Technology Studies (STS)
0207 679 1328 office | +44 207 679 1328 international
firstname.lastname@example.com | www.ucl.ac.uk/sts | @stsucl
postal address: Gower Street, London, WC1E 6BT | United Kingdom
street address: 22 Gordon Square, London, WC1E 6BT | maps


text:
Book your room at Detective Hôtel
Please enter your travel dates.
Get an overview of this hotelHotel in Etretat with bar/lounge
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
Located in the heart of Etretat, this hotel is within a 15-minute walk of Etretat Beach and Falaise d'Amont. Falaise d'Aval is 0.9 mi (1.4 km) away.
Hotel Features
A bar/lounge, meeting rooms, and a computer station are available at this smoke-free hotel. WiFi in public areas is free. Additionally, a library, multilingual staff, and a garden are onsite.
Room Amenities
All rooms are individually decorated and offer free WiFi and hair dryers. Flat-screen TVs come with satellite channels, and other amenities that guests will find include showers and phones.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Detective Hôtel features a library, a terrace, and multilingual staff. 2 meeting rooms are available. A computer station is located on site and high-speed wireless Internet access is complimentary. A bar/lounge is on site where guests can unwind with a drink. This Etretat hotel also offers a garden and a safe deposit box at the front desk.
Detective Hôtel is a smoke-free property.
- Total number of rooms - 13
- Number of floors - 3
- Bar/lounge
- Breakfast available (surcharge)
- Front desk (limited hours)
- Computer station
- Free WiFi
- Luggage storage
- Library
- Meeting rooms
- Multilingual staff
- Garden
- Terrace
- Safe-deposit box at front desk
- Number of meeting rooms - 2
- Smoke-free property
- Number of buildings/towers - 1
Family Friendly Amenities
- Free Wi-Fi
- Rollaway/extra beds available
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Room Amenities
- Phone
- Daily housekeeping
- Private bathroom
- Free toiletries
- Hair dryer
- Shower only
- Iron/ironing board (on request)
- Rollaway/extra beds available
- Blackout drapes/curtains
- Satellite TV service
- Flat-panel TV
- Free WiFi
- Free cribs/infant beds
- Connecting/adjoining rooms available
- Day bed
- Individually furnished
- Individually decorated
Where to Eat
Buffet breakfasts are available for a surcharge and are served each morning between 8:00 AM and 11:00 AM.
Nearby Things to Do
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Kayaking nearby
- Sailing nearby
- Bicycle rentals nearby
- Skydiving nearby
- Golf lessons available nearby
- Hiking/biking trails nearby
Hotel Policies
Check-in time starts at 2:30 PM
Check-in time ends at 11 PM
Special check-in instructions:
Check-out time is 11:30 AM
Payment types
Pets allowed, Maximum number of pets per room 2
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- No onsite parking is available.
No elevators
- A tax is imposed by the city: EUR 0.90 per person, per night. This tax does not apply to children under 13 years of age.
- Resort fee: EUR 0.90 per person, per night
- Fee for buffet breakfast: EUR 8 for adults and EUR 4 for children (approximately)
- Pet fee: EUR 5 per pet, per day
- Rollaway bed fee: EUR 15 per night
We should mention
This property's policy is to refuse certain bookings for the purpose of group events or parties, including pre-wedding stag/bachelor and hen/bachelorette parties. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
National Rating
This hotel has received its official star rating from the French Tourism Development Agency, ATOUT France.


text:
My job is to cover cutting edge technology, disruptive business models and innovative ideas.
Forget that. I was at the TechCrunch Disrupt conference looking for the wackiest, nonsensical start-up with an idea so wild that your jaw drops. A company so bad that, well, it may even be good. I give you Talk O'Clock. The "social alarm clock" with the tagline: "Let a stranger wake you up." Instead of using a regular alarm clock, you can have a random person you don't know call and wake you up. You don't know who will call you, though you can choose the gender of the caller. Users don't get each others' phone numbers because the company will dial the caller first, then connect him or her with the sleeper.
People who want to, say, yell and scream to wake others up, can choose who they want to call–they only see the person's first name–and select who they want to call. If the caller isn't there or no one is available at that time to wake a person up, Talk O'Clock has a robot caller.
Why in the world would you want a stranger calling you and why would you want to talk to someone when you're half asleep? Sometimes it's hard to wake up and hitting the snooze button doesn't work, says Alexy Kistenev, founder and CEO of Talk O'Clock. But a real person is much more likely to wake you up if they're talking to you. (Unless you hang up on them or turn your phone off, but we'll overlook that.) It's also a little bit of a game, Kistenev says, because well, you have no idea who the other person is you're talking to. You may even make a new friend, he says.
Still not convinced? There's another company in the space called Sleep.fm. With two companies in the space, there's got to be something there, right?
Honorable Mention: Ex-Rated is a website that came out of TechCrunch hackathon this past weekend, where hackers meet up and come up with a website idea on the spot and build it. The website enables people to rate their ex-boyfriends or ex-girlfriends. Then you can search people when you meet them and see the real dirt about them, instead of reading a profile on Match.com. There is also a browser plug in that overlays on Facebook so you can see people's "rating" from Ex-Rated while on Facebook. After all, the hackers said, you look at restaurant reviews before going to a restaurant, why not read a review of your potential mate? The idea is to learn about potential new partners from their exes. I can maybe buy that, but the other selling point is that the idea is to "help your exes improve." I think the attraction of the site will be more to maliciously rip into exes, not benevolently help them.


text:
|Schweb's Lounge Forum for general conversation, chit chat, or most topics that don't fit in another forum.
|Thread Closed
|Thread Tools
Member Since: Nov 18, 2006
Location: Anytown, USA
Posts: 4,925
Mac Specs: 27" iMac 2.7GHz Core i5, iPhone 4S, 3rd gen iPad
Some say opening up protected areas to drill would help solve the problem, but will it really?? Would these oil giants lining their wallets with our money because we have no other choice really lower the price just because there's more oil in the market? I honestly don't think so.
And yes, I know gas is also expensive in the UK, so you don't have to mention it. In Iran it's almost as cheap as water, so it's all relative to where you are and what your market is adjusted to.
"Give so much time to the improvement of yourself that you have no time to criticize others"
Member Since: Dec 03, 2006
Location: Irvine, CA
Posts: 9,385
Mac Specs: Black Macbook C2D 2GHz 3GB RAM 250GB HD iPhone 4 iPad 3G
Drilling is a temporary stop gap that will only help in the long term, and to be honest, should have begun during the last oil crisis in the 70s for it to have had any effect today. However, we should probably start drilling in addition to finding ways to curb consumption or find a way to get off oil so that we can ease the burden today and for the future.
Finally, the biggest factor in the inflated oil price is speculation. I say inflated because trading in oil futures has resulted in the price no longer being set by supply and demand but rather set by Wall Street, which is making a killing every time the price of oil goes up as various companies essentially are betting that it will. If we were to return to supply and demand, which was the case back in 2001 when Bush came into office and speculation was only a fraction of what it is today, the price would drop somewhere between 50% to 60%. If we could somehow manage to get the dollar's value back up, that price would drop even further.
Obama and the Democrats have promised to do something about oil futures speculation. While I'm not optimistic about anything happening (there's simply too much money being made on speculations, somewhere in the hundreds of billions of dollars), it would certainly be the best way to cut down the price of oil immediately.
June 2007
July 2009
Member Since: Aug 02, 2008
Location: Alabama
Posts: 26
Mac Specs: macbook 2.4ghz/4gigram/sd/leopard
I just hope the government steps back, and lets the market do its thing, no profits tax, don't restrict new drilling, leave it up to the states, etc.
if the market supports 4-5 bucks a gallon, then that is what we are gonna pay. Take solace in the fact that the higher the price goes, the bigger the incentive for individuals and companies to invent and manufacture ideas and products to compete with petroleum based products/industries.
Its like a scab, leave it alone, and it will heal faster
Member Since: Dec 03, 2006
Location: Irvine, CA
Posts: 9,385
Mac Specs: Black Macbook C2D 2GHz 3GB RAM 250GB HD iPhone 4 iPad 3G
I say we simply go back to the system that was working really well for us back in the late 90s. Sure, gas won't be under a dollar a gallon again with the increase in demand and the falling value of the dollar, but at least it won't be as insanely high as it is now. Though I would also recommend drilling to offset the next inevitable oil crunch.
June 2007
July 2009
Member Since: Oct 22, 2007
Location: London
Posts: 8,968
Mac Specs: Mac Mini Core i7 2012 | White 2009 MacBook 2 Ghz | 733 Mhz G4 Quicksilver
Also, as BuickGN says, the high price is pushing forward research into renewables (I have noticed the amount of proposed solar and wind projects suddenly ramp up), and accelerating research in to hydrogen and even nuclear.
Even Ford is realising that its obsession with SUVs was (in hindsight) a bad idea, and is hastily trying to switch production to its European models like the focus in the next couple of years.
Sure, the price hurts, but long term it will force us all to rely less on oil, which cannot be a bad thing for the world (both environmentally and for world politics)
Member Since: Dec 21, 2007
Location: Treasure Valley, Idaho. US
Posts: 406
Mac Specs: 20" iMac 2.4GHz w/ WD My Book 500GB HDD. MacBook Pro 2.4GHz. iPhone 5, white, 16 Gigs.
Hope Springs Eternal
Welcome... to the house of Rock and Jazz!
Member Since: Apr 08, 2005
Posts: 472
Member Since: Jun 17, 2007
Posts: 882
Mac Specs: macbook/iphone/ipod nano/ipod shuffle
the other thing to consider is when gas was around a a dollar a gallon just a few years ago that was the cheapest gas ever was after being adjusted for inflation.
i do not feel that drilling in alaska or off shore will suddenly drop the price of gas as new infrastructures will have to be built to handle it which would in turn cost more money. it would however decrease are dependency on foreign oil.
Member Since: Jan 19, 2008
Posts: 58
What I do find interesting is that yesterday I read an article that M.I.T has discovered a way to store solar energy. If this is true and we can implement this it would allow us to switch to a all electric world where we could never consume all the sun has to offer. Now if people can figure out how to make money providing us with solar energy our problems may be solved. Cross your fingers.
Member Since: Jan 29, 2008
Location: Mendocino, CA
Posts: 680
Mac Specs: 17" MacBook Pro A1151 2.16 GHz
There is no system but GNU and Linux is one of its kernels.
Join the FSF as an Associate Member!
Member Since: Aug 02, 2008
Location: Alabama
Posts: 26
Mac Specs: macbook 2.4ghz/4gigram/sd/leopard
95% of the time government control/intervention works to the opposite of what was desired. Remember, the same dolts who run the post office and the dmv will be running a MAJOR part of our economy? No thank you...... Same with universal health care.
like jram said, the government makes a ton of PURE PROFIT from every gallon of gas sold, without the expense of researching, exploring, drilling, refining, and transporting it to your corner gas station. Anyone who thinks the government is in a hurry to get us away from gasoline is fooling themselves. They stand to lose truly MASSIVE amounts of money, and that is anathema to every true politician.
Some wonderfully articulated ideas on this thread! Fun!
I am the Milkman
Member Since: Nov 04, 2006
Location: twin cities, mn, usa
Posts: 8,708
now, in my only somewhat tall subaru forester, i can most always see much farther ahead on any given road than i could in the past, and i know if some idiot crashes into me, they're much more likely to weigh much less then thay may have a year or more ago.
never mind the economy, the ecosystem*, etc. from a pure safety standpoint, putting more people in smaller cars makes everyone safer, not just those who were playing at a short-sighted arms race with the size of their vehicles.
* note: i am also quite glad for the environment as well that more people are putting more thought into the economy of their rides
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Member Since: Oct 10, 2004
Location: Margaritaville
Posts: 10,310
Mac Specs: 27" 3.4 Ghz i7 iMac-13" C2D Macbook-OSX 10.10.2 -64Gb iPad 2-64 Gb iPhone 6+-ATV 2-14Tb of Storage
Member Since: Oct 22, 2007
Location: London
Posts: 8,968
Mac Specs: Mac Mini Core i7 2012 | White 2009 MacBook 2 Ghz | 733 Mhz G4 Quicksilver
1) I did science at school (A levels - equivalent to a first year major in US colleges). As such I have been reading scientific literature since the 1980s and the consensus then was that we are heading towards climate change caused by man made CO2 emissions. Since the 1980s, the evidence has mounted up, so by the 1990s no serious climate scientist would doubt human contribution to climate change.
2) If it is a hoax a lot would have had to be done on a global scale. Scientists are generally an independently minded bunch, who insist in evidence being published and then reviewed by other scientists to see if their research stands up. As such, if evidence that global warming caused by us was baloney, you would expect the majority of scientists to stand up and say the research is rubbish.
The opposite is true. While major scientific journals like Scientific American, Nature and New Scientist regularly run articles expressing the research of climate sceptics, the vast majority of studies pointing towards our rapid alteration of the world climate and the problems this will cause are, frankly overwhelming.
If the whole global warming debate is a huge hoax, then most of the worlds scientists have secretly come together to agree to lie to us all about future problems that our planet is facing.
How somebody has managed to get the world scientific community to perpetuate a lie without some major leaks getting out is simply beyond me.
I don't for a moment expect to pursued any climate sceptics out there, but who is more likely to be true, a load of scientist from just about any country you can name, all acting in concert to hoodwink us all, or some people who may have shares in oil companies and who probably think that dihydrogen monoxide is a dangerous chemical.
Member Since: Sep 04, 2007
Location: Brandon, MS, USA
Posts: 807
Mac Specs: 24" iMac 3.06GHz 8GB of RAM 2TB HDD, 13" Aluminum MacBook 2.0GHz 4GB of RAM 500GB HDD
"I call this the Greatest Zooks Album." -CEREAL KILLER
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Today, we're thrilled to announce the next version of the Opower Thermostat Platform.
The new version of the platform has a number of added features, including support for Honeywell's Comfort Control API, which makes the platform compatible with additional Honeywell WiFi thermostats. In addition, the new platform update boasts the Set for Savings tool — a key new feature that makes personalized recommendations to customers based on energy and billing data to boost the potential for savings.
"As connected thermostats increase in popularity, there is a significant opportunity to integrate proactive advice based on energy and billing data into the customer experience," said Alex Kinnier, Opower's SVP of Product. "Set for Savings is our latest feature to not only help customers become more efficient, but to make their overall experience significantly more enjoyable."
Direct Energy — which is one of North America's largest energy and energy-related services providers with more than 6 million residential and commercial customer relationships — is our latest partner to deploy the thermostat solution at scale. With the deployment, a new smart thermostat rate plan will be available to all 700,000 of Direct Energy's residential customers in Texas.
"Direct Energy's connected home program gives our customers the ability to control and learn about their energy usage, through Opower's leading software and Honeywell's proven thermostats," said Adam Miller, Direct Energy's Senior Director, Innovation. "Direct Energy will match our expert home services network, which includes One Hour Heating & Air Conditioning, with Opower and Honeywell to bring together great customer experience, a high degree of reliability and a joint commitment to helping customers save money on their bills with a competitively priced energy plan."
To learn more about the new version of the platform, watch our Direct Energy Meridian Smart Thermostat video. And, if you're in San Antonio for this week's DistribuTECH conference, be sure to check out our presentation this Thursday, January 30th with Direct Energy and Baltimore Gas and Electric (BGE) on Transforming Your Customers into an Energy Resource.


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Gear Question
I was looking at ordering the Scarpa...
I was looking at ordering the Scarpa Booster, but no one seems to have my size. How are these compared to that shoe? Also, would you consider this a good bouldering shoe?
I have several pairs of the Booster/Mago/Stix shoes (of each) and the Boostic isn't quite as aggressively downturned as the the others but they're a bit more stiff which I think compensates for it pretty well. Also, there's no leather flap on the top of the Boostic where the "tongue" would be on the others as it's more of a mesh sock-like design similar to the Sportiva Solutions. Keep in mind that the heel cup is a bit different than the boosters as well. All in all, I really like the Boostic and would certainly recommend them.
View More Details on Scarpa Boostic Climbing Shoe


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For quite awhile now the Russians have had a long term strategy for undermining the European Union. Why would the Russians want to do such a thing? It's certainly not because of any principled objection to supranational institutions or a unique understanding of sovereignty. The Russians are in the process of creating their own "Eurasian Union" which deliberately echoes the EU in both its name and structure, and have no problem working within the confines of the UN, APEC, and other similar groups.
The reason that the Russians continuously try to work-around and undermine the EU is very simple: dealing with the EU as a whole is much more difficult than dealing with its constituent members on an individual basis. Compared to Romania or Bulgaria, Russia is a shark. Compared to the EU, it's a minnow. Russia's leadership understands that it can cut much better and more advantageous deals by working with individual governments than by working with the EU as a whole. And so when it comes to trade, and particularly when it comes to natural gas, the Russians eagerly try to divide and conquer their European "partners," splitting big from small, east from west, and pro-Russian from anti-Russian. The Europeans, for their part, try to present a unified front based on the simple and easily intuitive precept of "if we don't hang together, we'll hang seperately."
There is an ebb and flow to the Russia-EU relationship. The European Union presents a reasonably united front on some issues (human rights, democracy) and a rather less united one on others (energy) but things basically end up in a wash. Before the situation in Ukraine spun totally out of control, there was an uneasy standoff: boths sides understood that they were unlikely to "win," and so the EU didn't press the Russians too hard and the Russians returned the favor.
That has now changed. The other day Putin released a letter to the heads of state of 18 different countries that purchase large supplies of Russian gas, including 13 members of the European Union. The letter stated that Ukraine was no longer capable of paying its bills and that Russia "might" be forced to cut off supplies if Kiev's debts continue to go unpaid. Putin suggested that there was only one way out of the impasse: immediate high-level negotiations between the respective economic, finance, and energy ministers of all countries concerned. The goal of such negotiations would be to stabilize Ukraine's economy and ensure the continued delivery and transit of Russian gas.
Like many Russian proposals, the proposal contained within Putin's letter sounds perfectly reasonable at first glance. Who could be against negotiation? Isn't it perfectly sensible to get all of the interested parties together so they can figure a way out of this mess? A summary from Kommerstant, though, makes it perfectly clear what the real Russian goal is. Here's a translation of the relevant paragraph (emphasis added):
The president's press secretary, Dmitry Peskov, explained to Kommersant that they had in mind negotiations with every European country, and not with representatives of the European Commission. "Since every one of these countries is a purchaser of gas, every one of them should be a part of the negotiations" he said. "Holding negotiations only with the European Commission is impossible because they are not a purchaser." The Commission has for the past several years been trying to get the EU to present a united front against Russia in matters of energy, and has counterracted Gazprom's Gazprom's attempts to make individual deals with every country. The most striking representation of this position was the Comission's blocking of "South Stream" despite the fact that Gazprom had successfully reached agreements with all of the EU members participating in the project. In Brussels no one has yet commented on Putin's proposal. A Kommerstsant source in Brussels explained that on Thursday neither the European Commission nor the EU had received a copy of the letter.
The Russians aren't being very subtle about things. While they obviously have a genuine interest in getting Ukraine to pay its bills (Gazprom simply can't afford to give gas to Ukraine and not get any money in return) the real, and barely disguised, goal seems to be to break up the European Union's common energy policy.
Will it work? It's a bit of a long shot. You don't need a Phd in comparative political science or international economics to see that the EU and Russia aren't peer competititors. In demographic, political, and, especially, economic heft, the EU massively outclasses Russia. But the Russians aren't without leverage. They constructed the Nord Stream gas pipeline for precisely these sorts of situations: while Russia won't have a perfect ability to shut off Ukraine will continuing to deliver gas to the rest of their European customers, they will have much more ability to do so since the last major gas crisis in 2009. There's also the issue of the EU's continued economic weakness. Quite a few European governments, particularly in the South, don't particularly care about Ukraine and are in no mood for a dramatic showdown with Russia that could cut off gas supplies or send prices soaring. The Russians have already been quite successful at poaching individual EU members and it wouldn't be shocking if they are able to pick off a few more.
The Russians aren't strong enough to completely demolish the EU's common energy policy, and there's no chance that this ends with them in control of the whole continent's gas market. But Russia does have enough power and influence to seriously damage the EU's common front. Given how incredibly aggressive and unapolegetic the Russians have been over the past few months, it seems a virtual certainty that they will escalate their attacks on the "common energy policy" and that they will be even more active in trying to cut favorable deals with individual EU members. It's a big gamble, but it's one that could pay off.
Follow me on Twitter @MarkAdomanis and on Facebook


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Floor makeover DIY remedies
You may find yourself looking at your floors and other surfaces thinking that they need a remodel, but instead of spending a lot of money on a contractor, you can do some work yourself by adding a coat of epoxy floor coating. Applying epoxy floor coating is the most sought for method especially when it comes to improve the life of garage flooring. The epoxy floor coating is robust as well as gives a good finish to the garage floor. Now, not only can you park your vehicles smoothly but also use your garage for other purposes as well.
Garage is a place where damage on the flooring happens the most. There can even be spills of various oils, chemicals and grease. This spoils the beauty of the flooring. Also it can lead to various accidents like slipping and skidding. Therefore it is important that a garage floor should be such that such accidents could be avoided. Epoxy generally bonds well with the concrete flooring and the result is a durable and hard floor that is stain resistant.
Another option for the floors is polyurethane paint. But before applying this paint make sure you are applying epoxy primer. The result of this a high gloss and a durable floor. An acrylic polyurethane provides crystal clear protection. It is a fast -drying paint with the ease of water clean-up. Polyurethane paint is a hard coating and looks especially good on a back deck. Another DIY option is the latex paint. This one is comparatively cheaper than the above two. Latex paint needs at least 72 hours of drying and gives an antique look to your flooring. However, too much exposure to sun can damage your latex floor.
Among the flooring options mentioned above, epoxy is the best. It is easy to paint, is water-resistant, and easy to apply a swell. The resultant flooring is shinier, easy to clean, durable and maintenance free. When cleaning your floor, all you need is to mop it , and you are done. Polish your garage to a full shine and style.


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Hang tight!
Recipe by Carol
"I have raspberries growing in my yard, and I think of pie at this time of year."
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1 recipe
pastry for a 9 inch single crust pie
2 1/2 cups
1/2 cup
packed brown sugar
1 teaspoon
1 tablespoon
egg white
This pie was fantastic! We used frozen berries and I knew that I would need more cornstarch. I used about 3 tablespoons. I was unsure of the brown sugar as I have always used regular sugar. It was great! We have our own crust recipe that we used. Cannot wait to make it again!
A disaster. It was like a soup inside. Completely liquid. I followed the directions exactly. I don't know what went wrong. I think the temperature (400) may have been too high - at that level, I think the berries probably quickly liquified. And I did cut several slits in the top crust to let steam escape. Maybe you should mix the berries with the sugar and corn starch in a bowl first so the corn starch can actually work and hold the filling together. Really, it was a waste of the berries that I picked.
70 Ratings
I love this website and this recipe! The only thing i did differently in this recipe was mix honey with the remainder of the egg white and use it to glaze the top of the pie to give it that nice flaky give. Thanks!
This was a great, simple pie. Next time I will use a little less sugar, I found that sugar over powered the tast of the raspberries. Other than that it was great.
This was delicious! I liked the brown sugar with the raspberries. Everyone ate it up! I had a ten inch pie shell, so I doubled the recipe and used 3 tablespoons of flour instead of the corn starch (I don't like the cornstarch taste). It was perfect. Don't use frozen, grocery store, freezer section berries for this recipe. They are too moist, you don't want to use raspberries frozen in a solid block, not good for pies. Make this pie with fresh berries, when they are in season. Or use your carefully home frozen, fresh picked berries (Freeze fresh berries on a cookie sheet and transfer to a freezer bag after they are frozen, Do this within a day, don't freezer burn the berries. This way you don't have a big nasty frozen block of berries:) Good old fashioned recipe, will make again!
Excellent! And lower in fat than many of the other raspberry pies listed. Thanks! Even works great when you simply buy the pre-made pie shell crusts in the frozen section of the grocery.
YUM! And I hate berry pies! I had never made a pie before since I don't like them (was for the fiancé) and I was able to make this easily! I used 2 1/2 cups frozen blackberries and 1/2 cup frozen raspberries because I am a college student on tight funds. Still yummy! I would add a bit more corn starch if using the frozen berries since they have more water, but still just great! I used it with the Basic Flaky Crust Recipe on this site. Highly recommended!
* Percent Daily Values are based on a 2,000 calorie diet.
Raspberry Pie II
Serving Size: 1/8 of a recipe
Servings Per Recipe: 8
Amount Per Serving
Calories: 201
Calories from Fat: 82
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See how to make a sweet and tart, two-berry pie from scratch.
See how to make a wonderfully sweet and tart fruit pie.
Watch how to make this old-fashioned family favorite.


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Program Manager, School of Law (Job Id: UL172) « Position Deleted on 6/17/2014 »
|University of Louisville
|Louisville, KY
|Full Time
This position is no longer an active posting on HigherEdJobsJob ID: UL172
Location: School of Law
Equal Employment Opportunity
The University of Louisville is an Affirmative Action, Equal Opportunity, Americans with Disabilities Employer, committed to diversity and in that spirit, seeks applications from a broad variety of candidates.
Minimum Qualifications
J.D. and three years of related experience. The university offers market competitive salary and benefits. Grade EG
Position Description
Please note: this is the 80% FTE position with the salary of $40,000.00 annually.
The successful candidate will work with students in their transition to law school, will promote students' successful completion of the J.D. program, and will work with administration and faculty to provide students with a skill-set that will prepare them for the bar exam. The School of Law seeks to serve and retain a highly qualified and diverse student body, and the Director should have experience and training that will support working with a diverse student population. Ideally, the successful candidate will begin on June 30, 2014.
Some specific responsibilities of the Director of Academic Success include being responsible for the 1L Structured Study Group program, which includes providing curriculum, training, and supervision to Student Academic Fellows; working with students, individually and in small groups, on legal writing, time management, and test-taking skills; developing and conducting academic support workshops on class preparation, study habits, case briefing, outlining, and exam-taking; and assessing the academic success program, including the law school's bar passage, along with making periodic reports to the faculty on program outcomes. The Director should be prepared to develop and teach a one-hour Legal Methods Study Group in the spring semester.
Finally, the Director is responsible for working more generally with the Assistant Dean of Student Life and others, to help acculturate students to the rigors of law school and to provide support and referrals to students in need.
How To Apply
To apply for this position, follow the "Online App. Form" link below and then click on the title. You must answer all required fields and submit your application, including a a cover letter and a current resume, by clicking the "Submit" button. Vacancies are routinely removed from the jobs portal around 7:00PM each Monday.
Computers are available for application submission at the Human Resources Department located at 1980 Arthur Street - Louisville, Kentucky 40208. For more information, please contact us by email at firstname.lastname@example.com or by phone 502-852-6542.
If you require assistance or accommodation with our online application process, you may schedule an appointment at (502) 852-6542 with Employment Services at the Human Resources office located at 1980 Arthur Street, Louisville, KY 40208.
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text:
Now that is, Indeed, some poor translation work. Shubby is most displeased.
Is that some kind of collective consciousness he's floating in?
It's my version of the Akashic Records
@Rahka – no, this was Shubby in her earlier years.
just remember today new release! sooo … Shubshub will be coming up? nice … Great work ! can't wait for more!
Amazing artwork! I don't see how print can do this justice.
The Records are very much the Theosophists combination of the hindu version of the Recording Angel of St. John
& the Aleph
"Burton mentions other similar devices — the sevenfold cup of Kai Kosru; the mirror that Tariq ibn-Ziyad found in a tower (Thousand and One Nights, 272); the mirror that Lucian of Samosata examined on the moon (True History, I, 26); the mirrorlike spear that the first book of Capella's Satyricon attributes; Merlin's universal mirror, which was "round and hollow… and seem'd a world of glas" (The Faerie Queene, III, 2, 19) — "
Its a lovely idea: but its true Lovecraftian incarnation is the terrible Library of The Great Race of Yith.
My bad! It is the terrible library of the Great Race of Yith henceforth.
you gotta say the words good or you wind up like Ash, raising the dead. Buckle up, Boney!
In the second panel, I can't help but think of the Vaprous Brains of the Spiral Nebula.
Talk about getting into someone's headspace …


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Rx drug information, pharmaceutical research, clinical trials, news, and more
ERBITUX™ (Cetuximab) is a recombinant, human/mouse chimeric monoclonal antibody that binds specifically to the extracellular domain of the human epidermal growth factor receptor (EGFR). ERBITUX is composed of the Fv regions of a murine anti-EGFR antibody with human IgG1 heavy and kappa light chain constant regions and has an approximate molecular weight of 152 kDa. ERBITUX is produced in mammalian (murine myeloma) cell culture.
ERBITUX is a sterile, clear, colorless liquid of pH 7.0 to 7.4, which may contain a small amount of easily visible, white, amorphous, Cetuximab particulates. Each single-use, 50-mL vial contains 100 mg of Cetuximab at a concentration of 2 mg/mL and is formulated in a preservative-free solution containing 8.48 mg/mL sodium chloride, 1.88 mg/mL sodium phosphate dibasic heptahydrate, 0.42 mg/mL sodium phosphate monobasic monohydrate, and Water for Injection, USP.
ERBITUX binds specifically to the epidermal growth factor receptor (EGFR, HER1, c-ErbB-1) on both normal and tumor cells, and competitively inhibits the binding of epidermal growth factor (EGF) and other ligands, such as transforming growth factor-alpha. Binding of ERBITUX to the EGFR blocks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. The EGFR is a transmembrane glycoprotein that is a member of a subfamily of type I receptor tyrosine kinases including EGFR (HER1), HER2, HER3, and HER4. The EGFR is constitutively expressed in many normal epithelial tissues, including the skin and hair follicle. Over-expression of EGFR is also detected in many human cancers including those of the colon and rectum.
In vitro assays and in vivo animal studies have shown that ERBITUX inhibits the growth and survival of tumor cells that over-express the EGFR. No anti-tumor effects of ERBITUX were observed in human tumor xenografts lacking EGFR expression. The addition of ERBITUX to irinotecan or irinotecan plus 5-fluorouracil in animal studies resulted in an increase in anti-tumor effects compared to chemotherapy alone.
ERBITUX administered as monotherapy or in combination with concomitant chemotherapy or radiotherapy exhibits nonlinear pharmacokinetics. The area under the concentration time curve (AUC) increased in a greater than dose proportional manner as the dose increased from 20 to 400 mg/m2. ERBITUX clearance (CL) decreased from 0.08 to 0.02 L/h/m2 as the dose increased from 20 to 200 mg/m2, and at doses >200 mg/m2, it appeared to plateau. The volume of the distribution (Vd) for ERBITUX appeared to be independent of dose and approximated the vascular space of 2-3 L/m2.
Following a 2-hour infusion of 400 mg/m2 of ERBITUX, the maximum mean serum concentration (Cmax) was 184 µg/mL (range: 92-327 µg/mL) and the mean elimination half-life was 97 hours (range 41-213 hours). A 1-hour infusion of 250 mg/m2 produced a mean Cmax of 140 µg/mL (range 120-170 µg/mL). Following the recommended dose regimen (400 mg/m2 initial dose/250 mg/m2 weekly dose), ERBITUX concentrations reached steady-state levels by the third weekly infusion with mean peak and trough concentrations across studies ranging from 168 to 235 and 41 to 85 µg/mL, respectively. The mean half-life was 114 hours (range 75-188 hours).
A population pharmacokinetic analysis was performed to explore the potential effects of selected covariates including race, gender, age, and hepatic and renal function on ERBITUX pharmacokinetics.
Female patients had a 25% lower intrinsic ERBITUX clearance than male patients. The toxicity profile was similar in males and females. Definitive conclusions regarding the comparability in efficacy cannot be made given the small number of patients with objective tumor response.
ERBITUX has not been studied in pediatric populations.
The efficacy and safety of ERBITUX alone or in combination with irinotecan were studied in a randomized, controlled trial (329 patients) and in combination with irinotecan in an open-label, single-arm trial (138 patients). ERBITUX was further evaluated as a single agent in a third clinical trial (57 patients). Safety data from 111 patients treated with single-agent ERBITUX was also evaluated. All trials studied patients with EGFR-expressing metastatic colorectal cancer, whose disease had progressed after receiving an irinotecan-containing regimen.
A multicenter, randomized, controlled clinical trial was conducted in 329 patients randomized to receive either ERBITUX plus irinotecan (218 patients) or ERBITUX monotherapy (111 patients). In both arms of the study, ERBITUX was administered as a 400 mg/m2 initial dose, followed by 250 mg/m2 weekly until disease progression or unacceptable toxicity. All patients received a 20-mg test dose on Day 1. In the ERBITUX plus irinotecan arm, irinotecan was added to ERBITUX using the same dose and schedule for irinotecan as the patient had previously failed. Acceptable irinotecan schedules were 350 mg/m2 every 3 weeks, 180 mg/m2 every 2 weeks, or 125 mg/m2 weekly times four doses every 6 weeks. An Independent Radiographic Review Committee (IRC), blinded to the treatment arms, assessed both the progression on prior irinotecan and the response to protocol treatment for all patients.
Of the 329 randomized patients, 206 (63%) were male. The median age was 59 years (range 26-84), and the majority was Caucasian (323, 98%). Eighty-eight percent of patients had baseline Karnofsky Performance Status >/=80. Fifty-eight percent of patients had colon cancer and 40% rectal cancer. Approximately two-thirds (63%) of patients had previously failed oxaliplatin treatment.
The efficacy of ERBITUX plus irinotecan or ERBITUX monotherapy was evaluated in all randomized patients.
Analyses were also conducted in two pre-specified subpopulations: irinotecan refractory and irinotecan and oxaliplatin failures. The irinotecan refractory population was defined as randomized patients who had received at least two cycles of irinotecan-based chemotherapy prior to treatment with ERBITUX, and had independent confirmation of disease progression within 30 days of completion of the last cycle of irinotecan-based chemotherapy.
The irinotecan and oxaliplatin failure population was defined as irinotecan refractory patients who had previously been treated with and failed an oxaliplatin-containing regimen.
The objective response rates (ORR) in these populations are presented in Table 1.
The median duration of response in the overall population was 5.7 months in the combination arm and 4.2 months in the monotherapy arm. Compared with patients randomized to ERBITUX alone, patients randomized to ERBITUX and irinotecan experienced a significantly longer median time to disease progression (see Table 2).
ERBITUX, in combination with irinotecan, was studied in a single-arm, multicenter, open-label clinical trial in 138 patients with EGFR-expressing metastatic colorectal cancer who had progressed following an irinotecan-containing regimen. Patients received a 20-mg test dose of ERBITUX on day 1, followed by a 400-mg/m2 initial dose, and 250 mg/m2 weekly until disease progression or unacceptable toxicity. Patients received the same dose and schedule for irinotecan as the patient had previously failed. Acceptable irinotecan schedules were 350 mg/m2 every 3 weeks or 125 mg/m2 weekly times four doses every 6 weeks. Of 138 patients enrolled, 74 patients had documented progression to irinotecan as determined by an IRC. The overall response rate was 15% for the overall population and 12% for the irinotecan-failure population. The median durations of response were 6.5 and 6.7 months, respectively.
ERBITUX was studied as a single agent in a multicenter, open-label, single-arm clinical trial in patients with EGFR-expressing metastatic colorectal cancer who progressed following an irinotecan-containing regimen. Of 57 patients enrolled, 28 patients had documented progression to irinotecan. The overall response rate was 9% for the all-treated group and 14% for the irinotecan-failure group. The median times to progression were 1.4 and 1.3 months, respectively. The median duration of response was 4.2 months for both groups.
Patients enrolled in the clinical studies were required to have immunohistochemical evidence of positive EGFR expression. Primary tumor or tumor from a metastatic site was tested with the DakoCytomation EGFR pharmDx™ test kit. Specimens were scored based on the percentage of cells expressing EGFR and intensity (barely/faint, weak to moderate, and strong). Response rate did not correlate with either the percentage of positive cells or the intensity of EGFR expression.
All Rights reserved - Copyright DrugLib.com, 2006-2015


text:
Copycat recipes for elephant bar
Recipes / Copycat recipes for elephant bar (1000+)
Brides Bars
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mix, 2 x Large eggs for chewy bars or possibly 3 Large eggs for cake bars, 1 whl can pie
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January Daring Baker's Challenge: Nanaimo Bars!
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and Nanaimo Bars as the challenge for the month. The sources she based her recipe on are
Paleo Lemon Bars
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3/4 cup Lemon Juice 1/2 cup Coconut Oil For the Bars: 1/2 c. Pecans (or walnuts) 1/2 c
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recipes will do that! My youngest daughter Lauren worked for Nordstrom's for
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recipe in their recipe box, and really, these barsAbout 24 bars Ingredients For the
Quick and easy granola bars
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a spoon. Tons of crumb bar recipes use jam or Blueberry Crumb Bars Ingredients for the
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for 2, Recipes for 2. I used to have 4 kids to eat now its just me and my dh. looking for
We who cook for our PETS
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who cook for our PETS, Recipes for your pets. I happen to cook most of the food for my two
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Simple No-Bake Recipes for Summer
easy recipes that will delight even the toughest food critics? Try these recipes for your
Recipes for me.
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Brunch Time!
want to wait on. And here's one last recipe for you: Mimosa: 1 part orange juice, 1 part
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Disabled but still Cooking, Easy, simplified recipes for those who can't stand in the
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