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A.A. Boos wins Build Ohio Award for GateKeeperWritten by Duane Ramsey | | email@example.com
A.A. Boos & Sons Inc. of Oregon was selected as one of the recipients of a prestigious award for its role in the construction of the GateKeeper roller coaster at Cedar Point.
A.A. Boos received its bronze and green marble Build Ohio Award during the 22nd annual Build Ohio 2013 Celebration conducted by the Associated General Contractors of Ohio on Nov. 15 in Columbus. The company was honored for its unique work on GateKeeper, which was completed in the spring of 2013 for Cedar Fair Entertainment.
"We thank our partner, Cedar Fair, for being such a wonderful partner and for demanding that all components of this project be built in Ohio by Ohioans," said Scott Hayes, vice president of A.A. Boos.
Hayes said the project was designed by a roller coaster design firm in Switzerland but all of the parts and skilled labor originated in Ohio.
A.A. Boos functioned as the general contractor for the $30 million GateKeeper project that was started in September 2012 and completed in April in time for the coaster's official debut May 11.
"It was a complicated and challenging job that our talented workforce embraced. They approached this endeavor with creativity and flexibility, and most importantly, performed this job safely," Hayes said.
"We have the best product on the planet: our people. We have a consistent workforce that's centered around health and safety. Everything starts with that. We keep our employees safe in a very dangerous industry," he said.
Hayes said that most of their 160 employees have worked there for many years, which has allowed them to learn the way A.A. Boos does things.
Top management is committed to involving the employees in the process through continuous communication, holding people accountable to see that the plan is executed.
"This is the most difficult foundation job I've ever done," said Seth Vargo, project manager at A.A. Boos, about their work on the GateKeeper.
A.A. Boos was responsible for laying the 250 foundations, or footers, required for the GateKeeper project, 196 for the coaster and another 54 to support buildings associated with it, Vargo said.
The plan for those foundations looks like a random pattern, like stars in the night sky just plunked down here and there.
"It might look random but each one has to be exactly aligned and, with very few exceptions, no two foundations line up or are oriented in the same direction," said Carl Schober, surveyor for A.A. Boos on the GateKeeper project.
"It all comes together like a big erector set. There is no room for error because lives hang in the balance. And all of this precision is built on sand," said Mark McGee, project superintendent.
McGee said the Cedar Point peninsula makes construction operations extremely difficult as they're working on what he said is basically an island. They had to build roads to get the concrete and pumps in place where needed because the sand wouldn't support the weight.
The company committed two of its best to this project by designating McGee as superintendent and Schober as surveyor, Hayes said.
"We had an excellent crew. Everybody came every day. There were no excuses for rain or snow. They wanted to be part of making history here," McGee said.
Cedar Point set seven world records with the addition of the GateKeeper, according to Cedar Fair Entertainment. The seven records are:
- Longest wing coaster at 4,164 feet.
- Fastest non-launched wing coaster at 67 mph.
- Tallest inversion on any roller coaster at 170 feet.
- Longest drop on a wing coaster of 164 feet.
- Most inversions on a wing coaster with six.
- Most roller coaster track at one park with 56,702 feet.
- Most rides at one park with 72.
GateKeeper greets guests with two rolling flyover maneuvers while slotting through "keyholes" over the new front gates to Cedar Point. The attraction thrilled more than 1 million riders within 10 weeks of its opening.
Underneath the high-flying excitement is 12 million pounds of concrete in 250 footers built by A.A. Boos.
Many of the workers from Boos were among the first to ride GateKeeper. When asked if he was nervous being one of the first to ride it, Hayes replied, "Absolutely not. I have complete faith in the way it was built."
Tags: 22nd annual Build Ohio 2013 Celebration, A.A. Boos & Sons Inc., Associated General Contractors of Ohio, Build Ohio Award, Carl Schober, Cedar Fair Entertainment, Cedar Point, Columbus, Ohio, Oregon, Scott Hayes, surveyor for A.A. Boos, Switzerland, The Gatekeeper roller coaster, vice president of A.A. Boos


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Baby's first Doll is tickled pink and happy to meet your baby girl! Doll is lightly stuffed for baby to hug & hold, with pretty ponytails for tugging & teething.
A portion of the proceeds from this item supports breast cancer research. You'll feel good giving your baby a toy she'll love and one that will also benefit a good cause.
- Soft organic velour; stitched details
- Natural corn fiber filling
- 8" tall

subset: commoncrawl


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Now that LinkedIn has demonstrated the huge opportunity to build social tools for corporate recruiting, the startup wars have begun.
Dozens of companies are now launching tools to help recruiters find candidates and candidates find jobs. And in the middle of this, another set of startups is trying to automate the "part-time" work environment, enabling people without full-time work to find part-time gigs.
The recruiting market is very large (we estimate over $140 billion is spent by US corporations alone, to say nothing of all the money spent by candidates trying to find jobs), so there is a lot of opportunity for disruption and new businesses.
Think about it this way. Every year, regardless of the economy, around 40 million people change jobs in the US alone. There is a huge need for tools to make this whole matching game easier.
Let me highlight a few of these exciting young companies:
Path.to and Bright: These companies try to mine your social graph and "find jobs" for you. So far they're just getting started so the matching isn't very good yet, but the potential is big. Think e-harmony for the job seeker.
Identified.com: a new "gamification" type of job search system which gives job candidates a "score" based on their social connections, experiences, and perceived skills. A "data science" company which hopes employers will be able to use this "score" to assess candidates (just received $21M in capital).
Recmnd.me is a "recommendation building" tool for candidates, it lets you promote and create more recommendations through your social network.
Smarterer helps you as a job candidate prove your skills by taking assessments, helping candidates and recruiters better find validated skills (LinkedIn is working on this).
Zao is building a system to create referrals through your social network, enabling you or employers to give referral fees to anyone who suggests you or others for a position.
Gild, a fascinating new company that actually locates and evaluates your code (if you're a computer programmer) and sends evaluation scores to prospective employers. More to come from these folks.
TalentBin: Gives recruiters an intelligent tool to find people through their social graph. Kind of the opposite of Path.to and Bright.
Startwire gives candidates updates on the status of their applications. It's like a "Tracking System" for all your job applications. Not a bad idea, considering the fact that over 70% of all applications get no response at all.
Jobvite: A fast-growing company which delivers referral recruiting tools, applicant tracking, and advertisement management tools for recruiters. Gooodjob is a startup building a similar offering.
In the assessment market there are dozens. EmployInsight is a new company which collects candidate data and offers in-line assessments online, attempting to build up a global skills database.
Bullhorn: one of the biggest end-to-end social talent acquisition solutions, focused on the staffing industry (recently acquired by Vista Equity).
Jobs2Web: (acquired by SuccessFactors) a candidate marketing and analysis system that helps recruiting organizations manage the recruitment marketing process.
SmartRecruiters: a no-cost (yes, free) cloud-based applicant tracking and social recruiting system which lets recruiters post jobs on Facebook with the click of a button.
LinkedIn Talent Pipeline: a new offering from LinkedIn that lets recruiters manage the end-to-end interactions of all their candidates (including social activity) throughout the recruitment process.
BraveNewTalent: Creates professional communities and entices candidates to find employers (and vice-versa) by matching their interests and needs. TalentCircles and SelectMinds have similar offerings.
GigWalk, Freelancer, TaskRabbit, eLance, Odesk: Contract work systems that help people post their skills and project managers look for skilled people for project work. These systems are becoming location-aware so many run on a mobile device and can show you local gigs automatically.
ViewsOnYou and Glassdoor: ViewsOnYou lets you do a 360 assessment of yourself and match yourself against others and potential employers. Glassdoor does the opposite – it forces employers to do a 360 whether they like it or not (employees and former employees rate the employer).
Work4Labs, Tweetmyjobs, Tweetajob, and many others help recruiters rapidly use Facebook or Twitter to post and tweet job openings to communities and audiences. Work4Labs (Work4Us) is a complete Facebook application platform that lets recruiter build a Facebook recruiting site, similar to the "career pages" you can develop on LinkedIn.
HireVue and InterviewStream, TaketheInterview, companies that make it possible for recruiters to interview you via video you capture on your phone or PC.
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Every shoe in our lifestyle line has a performance legacy that helped it earn classic status. From limited releases to updated basics, new colors and styles are constantly added — if you're a sneaker collector, keep this page bookmarked.
997 Distinct Mid-Century Modern
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577 Made in UK Flying the Flag


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Speech has to power to unite, to convince, and to energize.
But a great speech is more than just words. It's a haystack of words and context and delivery that, together, create energy that inspires and motivates the listener to believe or act upon emotion.
Below are 3 of the top motivational speeches I've come across. Share your favourite speeches in the comments below.
1. Arnold Schwarzenegger's Motivational Speech – including his 6 rules of success
Discard any preconceptions you have about Arnold Schwarzenegger and listen to this speech!
Arnie's thought process will reveal exactly why he had the energy to win Mr Universe, create one of the most recognizable Hollywood characters in history, then become a successful writer, businessman, philanthropist and politician.
2. Les Brown – You Gotta be Hungry
This is a slightly longer speech from one of the most amazing, inspiring, and strong speakers I've heard in my life.
Les Brown's speeches are less well known than our number 1, but will spark something powerful within you!
Sit down for an entertaining and empowering 40 minute session, or load the video up on your Iphone and listen in snippets.
I personally have listened to this one over 10 times, and gain something new every time.


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Tag: briar patch flowers and gift shop
Cash Mob Hits Island Falls Gift Shop
It's Christmas shopping season, and during this time many communities remind holiday shoppers to patronize their local businesses. One woman had just that in mind when she planned a cash mob at a small store in Island Falls on Saturday. News Source 8's Katie Zarrilli has more.


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Science Matters
Aging Water Infrastructure
EPA researchers and engineers work to help communities deal with aging and failing drinking and wastewater systems.
On the morning of December 23, 2008, drivers in suburban Maryland were confronted with a torrent of water rushing down River Road. Somewhere beneath the pavement, a 66-inch water main ruptured, allowing some 150,000 gallons per minute to cascade onto the road in standing waves three to four feet high. Rescue crews launched from boat, fire engine, and helicopter were able to rescue all stranded motorists and their passengers. Luckily no one was hurt.
Following a four-month forensic investigation, The Washington Suburban Sanitary Commission determined the cause of the water main break could be traced back to its original installation in 1965.
At 43 years of age, the pipe lurking beneath River Road was relatively young compared to many still in use in areas of the country that are easily twice that age, or older. The nation's water infrastructure—the pipes, treatment plants and other critical components that deliver drinking water and remove and treat waste water—is aging.
Age and deterioration are taking a toll. Every year across the country, there are approximately 240,000 water main breaks. As many as 75,000 yearly sanitary sewer overflows discharge three to ten billion gallons of untreated wastewater, leading to some 5,500 illnesses due to exposures to contaminated recreational waters.
EPA researchers are taking action to meet the challenges of the nation's aging water infrastructure.
The Agency's report, Clean Water and Drinking Water Infrastructure Gap Analysis (PDF) (54 pp, 2.3 MB), a comprehensive assessment of the difference between needs and spending on the nation's water infrastructure, identifies a potential $500 billion gap in funding by the year 2020, in large part due to aging.
"EPA works with collaborators and stakeholders to conduct projects that will fill identified aging drinking water and wastewater research gaps," said Thomas Speth, Director of the Water Supply and Water Resources Division at EPA's National Risk Management Research Laboratory. "The application of new technologies and management practices from this research could also narrow the large funding gap."
Engineers and scientists in the EPA's Aging Water Infrastructure Research Program are working to identify critical research needs and to develop, test, and demonstrate innovative technologies that will assist communities to address the challenges of aging water infrastructures by reducing the cost and increasing the effectiveness of existing or new infrastructure. EPA researchers collaborate with partners and stakeholders in four primary research areas: condition assessment, system rehabilitation, advanced concepts, and treatment technologies for wastewater and water reuse.
The Program supports EPA's larger Sustainable Water Infrastructure Initiative, which guides efforts to change how the nation views, values, manages, and invests in its water infrastructure. Both programs are based on forging successful partnerships, bringing drinking water and wastewater utility managers, trade associations, local watershed protection organizations, and federal, state, and local officials together to ensure that all components of our nation's water infrastructure are addressed, and see that EPA's research results reach those who need it most.


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Newbies, Post in Welcome Central to open up the boards
0 Members and 1 Guest are viewing this topic.
Jabcat (is it James?) Paul was so urgent to share the Promise of the Spirit with people that he became "all things to all people, so that he could save some." Of course he means "I, yet not I" when he talks about saving them.I do agree with what you say though. Nobody sees the father apart from Christ. If we are to share the teaching that the gateway to life is narrow and the gatway to being lost is wide, then we should do it and accept our beatings for Christ (for our decidedly non-ecumenical behavior). Either that, or rejoice that they have come to Christ, rather than Bhudda et al, so that they can have the oneness in the Spirit that sets them free.


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MacKenzie appeared in 377 games with the Wolves over six seasons, amassing 83 goals, 101 assists, 184 points and 441 penalty minutes. He helped Chicago capture its first Calder Cup championship as a rookie during the 2001-02 season, and returned to the Finals again in 2005. The Sudbury, Ontario, native still holds a franchise record with 21 career shorthanded goals.
Following the 2006-07 campaign, which MacKenzie split between the Wolves and Atlanta Thrashers, the now 29-year-old forward signed as a free agent with the Columbus Blue Jackets. He has since split time between Columbus and their former American Hockey League affiliate, the Syracuse Crunch.
After departing the Wolves, MacKenzie continued to excel on the penalty kill, and captured a second team's franchise record for shorthanded goals, notching 11 in 173 games with the Crunch, spanning three seasons.
The former Wolves captain appeared in an NHL career-high 18 outings with the Blue Jackets last season, amassing three assists and four points. Overall, he has skated in 36 NHL contests with Columbus since departing the Thrashers organization, tallying three goals and six points from 2007 to 2010.
You can follow along with this Wolves alumnus here.


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Course Abstract Details
ART-135, Art of the Western World, Prehistoric-1300
Credits: 3
This is a General Education Course
Course Description
ART-135, Art of the Western World, Prehistoric-1300, introduces students to the arts of painting, sculpture, and architecture from Prehistoric to the Renaissance. The course will focus on the meaning of the artwork, on exploring and unfolding the works iconography and ideas, on its projection/reflection of human values, and on the relationship of this historic expression to our own milieu. Emphasis is thus centered on students' understanding and development of their dialogue with Western cultural heritage and its non-western influences. Prerequisite: exemption/completion of READ-099. Three hours lecture each week. Three credits. Three billable hours.DIVERSITY/WORLD VIEW. GENERAL EDUCATION Offered Fall and Spring terms.
Learning Goals
The abbreviations in parentheses represent Learning Goals which have been identified for this course and program of study:


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PdaNet updated to hide unauthorized tethering [Jailbreak]
PdaNet, the popular (and free) tethering app in Cydia, has been updated to mask unauthorized data tethering. This comes after carriers like AT&T have started cracking down on iPhone owners who use MyWi to tether without losing their unlimited data plan.
AT&T has been flagging any packets that appeared to come from a secondary device before sending out a notice to users. PdaNet prevents this by using a method of masking packets sent through the network so your carrier can't tell if the data is coming from a device other than your iPhone.
The app also includes features like USB tethering and basic Wi-Fi security in addition to controlling the broadcast channel and WiFi signal strength, just like MyWi. You can either use the free version, or upgrade to the full version for $15.95 (limited time deal, normally $29) to access secured websites.
Any readers out there using PdaNet? What do you think of it?
Have something to say about this story? Leave a comment! Need help with something else? Ask in our forums!
Andrew Wray is a Salt Lake City, Utah based writer who focuses on news, how-tos, and jailbreak. Andrew also enjoys running, spending time with his daughter, and jamming out on his guitar. He works in a management position for Unisys Technical Services, a subsidiary of Unisys Corporation.
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Reader comments
PdaNet updated to hide unauthorized tethering [Jailbreak]
I downloaded the full version and it works very well but I had to go back to MyWi since my nook color couldn't pick up the PdaNet. It works great for my friend though since MyWi wouldn't connect with her gen 1 iPad.
To connect iDevice to iDevice, you need to download and purchase MyWiOnDemand.
Or just use WiFi...
People fail to realize that it's less packets from other devices, by means of tethering, and more data consumption in general that's causing AT&T to flag customers with these ridiculous messages.
That's a complete lie. I've used well over 12GB for the past few months and I haven't received anything from AT&T. I picked up MyWi's trial because we were not going to have Internet for 3 days and the day after I used MyWi I got dinged for tethering.
Learn your information before opening your mouth.
I've been using MyWi for several months, but only 150-200MB per month (much less than most people use with their device alone), and have never received a message from AT&T. If they weren't looking at data usage, I'd have been contacted by now.
I use approx 7gb a month but only 1gb on tether, just to download e-mails on the run, 15 minutes after downloading via e-mails via PDANET I got the text. Havent used it since but will upgrade now and start again.
Odds are strong that high usage throws up the initial red flag since that's the easiest thing to notice. After that they probably watch those flagged user for signs of tethering.
There is no guaranteed, to hide you by using tethering... But at&t they flag those hot and huge data usage specially for those have unlimited data plan for the following reason:
1. If you used too much data each month, AT&T will flag your account regardless of tether usage.
2. Your account is already flagged and marked as hot account.
Matthew, this is only a tech blog... no need for hostility. Second, I am speaking from experience. I was grandfathered with an unlimited iPhone data plan from the 1st gen iPhone. I too used incredible amounts of data, ranging from 5GB to 17GB, the entire time I've had my iPhone(s). It wasn't until 3 weeks ago that I received a message from AT&T saying that they were going to switch me to an appropriate tethering plan. Funny thing is – I've never tethered…. Moreover…. I've never Jailbroken my phone.
I regularly us hundreds of gigs. They've never texted me.
Per month? I highly doubt that...
Really dude, your a retard
Bro I play warcraft tethered and it hardly uses any data... more like hundreds of megabytes.
I'd agree to a certain extent, but remember that you can watch Netflix on your iPhone now. I've noticed data usuage of around 4gb on my phone just from watching a movie here and there. Maybe ATT is different, but no issues on Verizon.
I just spoke with a representative and she confirmed that they don't care about data usage, only the type of data usage. They are monitoring for the tethering data signature on accounts that don't pay for tethering. I hope MyWii comes out with a similar packet disguiser.
Gotta stay one step ahead of the MAN.
I has used it on a Moto Droid a while back, and was thrilled to find it on Cydia when I jailbroke my phone. It works great to connect to my iPad. Been using for a few weeks with no issues
*jailbroke my iPhone
I use MyWi and have not received any notifications from AT&T. I also have only gone over 2 gb in a month once since using it. I'm with those saying it's the amount of data usage that's triggering the notification. Also, it's been well over a couple of months since we heard people are receiving the notices. Has anyone actually been converted to a tethering plan against their will yet?
I'll let you know if it is MyWi in about a week. When stranded at the airport this weekend, I used MyWi on my iPhone to teather to my iPad. I then used my iPad to watch my DirecTV during the Osama news. I burned through 600MB in about 45 minutes.
How did you use direcTV to watch? The app that I have doesn't support watching live tv from iPad.
I got dinged by AT&T yesterday for the first time. The agent guaranteed that they did not use usage as a detection method and said he regularly uses >15gb per month without tethering. He also repeatedly said there are 240 people who have fought the accusation and AT&T was able to prove all 240 had tethered. I agreed not to tether in the future so as not to lose my unlimited plan. Not sure if this guy was full of it but thought I'd share my experience.
I don't doubt for one minute that they're flagging packets from other devices. But, maybe once they find them, they then look at that customer's data usage. Perhaps those who are tethering with well below normal usage are being left alone (maybe not). I've never used more than 200MB total per month in three years with any iPhone. If some of that is from my tethering, I don't see a problem when others are burning through 15GB with their mobile devices alone.
I guess time will tell.
How do I jailbreak a 4.3.2 iPhone 4?
don't do it. you'll mess up yur phone
I've jailbroken before and it worked perfectly!
no issues with verizon thats why is the best
yes, lipe, you are correct. in fact i have forwarded your comment to the CEO of AT&T and he said they will be shutting down operations first thing Monday morning.. Happy Now??
Putting your sarcasm aside, he has a point.
iPhone isn't exclusive anymore. If this ends up pissing off enough AT&T iPhone users that they move to Verizon, AT&T's policy will change.
What iOS is everybody on? I am jailbroken on 4.1 and tether my iPad to iPhone 4 with MyWi. No death threat so far.
I'm starting to think it has something to do with the firmware. I tether everyday on a JB 4.0.1 (MyWi) and haven't received any messages. I'm thinking something was implemented in a later firmware that allows AT&T to check tethering.
I have been using this new PDANET version with hide for a few weeks... but I still got the email and text from AT&T. I was even using the "Level 2" hide function. AT&T's method of detection appear better than the block. My typical usage was around 3Gb, so amount of data is not the primary gauge. There appears to be no option for just "a little" tethering.
Have you been in contact with the PDAnet developer? It would be interesting to hear their take on your report.
TIPB- it would expect the developer to withold info on their technology, but perhaps this report would be worthy of a followup interview with them. Have they made changes in recent days that would have pevented Clayman's problem?
Clay man- when was the last time you updated your PDAnet?
So this doesnt necessarily mean that it wont use the 2gb, meaning it WILL use the 2gb, but just not tell ATT that youre tethering right?
so its not like i can use all this data and it wont reflect my bill right?
has anyone with the BB "Tether" application received these texts?
Isn't data on the BB encrypted through RIM's servers? If so that would make it impossible for AT&T to packet sniff their data.
there has to be some kind of tracking, else the FBI wouldn't like that.
Apple already doesnt like Jailbreaking and now apps are enabling jailbreakers to steal service from the carriers. This could elevate jailbreaking from an annoyance to something apple will be justified in shutting down.
Jailbreaking is legal. Apple can't just 'shut it down"
And a whopping 1GB download every time there is an update doesn't justify X.X.X upgrades just to patch jailbreak loopholes.
How is it stealing service? My Mom is on the 3 GB plan for $30 dollars a month. She was tethering using MyWi and only was using 2.5 GB of her 3GB data cap. But she still got the text, and email from AT&T saying they were going to switch us to a tethering plan.
With that being said, how is it any different than putting say 3 Gallons of fuel in my car and Shell, or Exon, or BP telling me I can only drive a certain distance....DOES NOT MAKE SENSE!!! Its data that I have paid for, if i was abusing it by going over then charge me for the overage, but if I am staying within my limit of my 3 GB cap whats the freaking problem AT&T?????????!!!!
Stopped using PDANet a long time ago. It was too buggy. TI found a better & cheaper solution as well.
Why would you condone theft???????
How is it theft? The service is paid for, what difference does it make what device was used to access the service. That'd be like the cable company charging you per TV in your house. If anything, multiple surcharges for the sane service is illegal. That said, AT&T does reserve the right per the user agreement to charge for enabling tethering. But really there is no legal backing to support their double tariff practices.
So if an all-you-can-eat buffet is already paid for, it doesn't make a difference whether you fill up a dish with food or fill up a wheel barrel with food?
Unlimited data for iPhone is intended for iPhone use only.
I think most people realize that those on the unlimited plan who are tethering (especially things like laptops) are abusing their contracts. However, it seems crazy to me that those on a metered plan, ie 2gb etc, would be forced to by ANOTHER 2gb, just to use tethering, regardless of how much they actually use. If I've bought 2gb of data, I should be able to use that however I like since I'll have to pay for overages regardless since it is not costing AT&T anymore. If I've bought unlimited iPhone data, it seems reasonable to require it be used on that device, since every byte I use reduces AT&T's profit.
I agree. I probably tether for ten minutes, a couple of times per month, just searching the web when I'm with clients. I haven't been contacted (yet), and I believe it is because I don't abuse it.
Why would AT&T want someone like me, who never even gets near 300MB per month, to switch to Verizon just for using a tethering app for 100MB a month?
Would you flip to Verizon if they contacted you, then graduated your plan?
I agree. If you are paying for 2gb you should be able to use it as you wish. Unlimited is a different story. Just my 2cents
I'm surprised no one has taken AT&T to court to challenge this crap. Come on, someone has to have more spare time and money than I do to handle this. lol
You cannot take ATT to court because your contract states that you will not use the ATT data plan for any service other than your phone. However, it is possible that some of us who were grandfathered in to unlimited data plans, never signed such a contract. In either case, the ATT contract also states that if ATT decides to increase or add services to your ATT monthly Bill, you will have the option of cancelling your account, without paying for the early termination fee, plus you can keep the phone. Its in your contract, read it.
I tether, I do not pay for tethering (I think ATT is the worst company in the world and would love the chance to switch wireless services). I use PDANET with the hide feature and have not had any issues. I use anywhere from 2GB to 8Gb per month.
We sign a contract for unlimited Data,text,and calls,now they are gonna cut I service speed down after 3G to try to weed the unlimited plan out cause they didn't think of how much DATA was gonna be used in time to come.Now it's costing them money for unlimited uses.We are the ones that AT&T are try(No they have already started) to make us pay for poor service(low speeds) that isn't what we sign a agreement (contract) We auh to be offered some kind of deal,are keep our agreement. We the 5% Can we sue for a greet price for just doing this to us?As long as we made our payment for service.there got to be some way we can make them pay,they are making us pay now.please comment.All of us can together can make something happen.
What's the difference btween filling up a wheel barrel with 20 plates and carrying 20 plates 2 at a time to my table? It's still 20 plates to me.
Im on VZ and feel ATT users' pain.
I pay for unlimited data, how is it stealing if I tether? Sure I'm using it on another device, but I pay for UNLIMITED DATA - that means without limit. So if I want to let my phone run netflix all day out to hundreds of gigs, that's ok but to use 2mb of tethering to check email is stealing? The very assertion is puerile and stupid. ATT are giant tools and I am sure will face class action soon.
Don't need it as my data plan includes tethering.
Hey guys I know this sounds ridiculous but I actually use about 40gigs a month reason being that besides using my laptop for netflix, you tube, and among other things, I also connect my laptop to my Xbox and play a lot online so...I'm guessing for that my usage goes up high and yes I got my text of death from AT&T about 3 weeks ago...
I have used MyWi for about 1 year. Used 6g & got my tether death threat letter & text. Paid the 15.95 for pdanet. Does pdanet really block your tethering usage from sister AT&T's eyes? Has anyone tested it?
I got the text yesterday for the third time only this time I was being told that my account has now been "upgraded" to the data pro plan and to expect a change in my billing soon. Btw (iPhone 3GS/iOS 4.1/jailbroken/mywi/5-10gb-pr month) I called and told the lady I would have no choice but to drop my plan and she then went and checked my information( I had called and argued once before that I use alot of data just on my phone) then the lady comes back after checking and says she sees nowhere where my account has been changed and says text was prob sent to you because they figured you wanted to tether your phone. I say no and she says well the text was sent in mistake and to disregard it. Are some Att reps just thT niave or is it reAlly just fishing by Att? She also they would never change my plan without first consulting me. I'm at a loss. Seems more like a fishing expedition against hi bandwidth + grandfathered users. They wAnt you off that plan so bad cause 15$ more a month with a data cap is their new gold mine right now.
I have been using pdanet on my iPhone 4 with the hide usage feature selected and I still received the warning email from AT&T about converting my account to a tethering plan. Anyone figure out how to really hide tethering usage from carriers?
Thanks for the heads up. I almost switched to PDANet from MyWi
Really? Which level protection were you using? I too almost lOst my unlimited plan, and I was really hoping pdanet was the answer!
do you use level I or lever II to hide?
I really hope this works. I just got the JB tethering threat too. As far as I've heard Jayhonda, AT&T is sending the message to anyone with high data usage. I've read claims of people arguing that they stream netflix and hulu 24/7 and backing AT&T down with this argument. I'm wondering whether AT&T and Apple are within their legal rights to demand that we only use their products (jail breaking was upheld by the Supreme Court after all). Maybe (hopefully) AT&T is just being a greedy bully and data jacking anyone who rolls over for the man. I've paid for my unlimited data plan since the very beginning, and it doesn't seem right to me that AT&T can just demand that we only tether with their inferior yet more expensive tethering plan, which I believe is used by iPhone browsing & tethering combined. What a rip-off!!! I hope they lay off, or I will be literally forced to terminate my plan and head to another carrier. My bill is already $240 dollars a month, I wouldn't be able to afford the inevitable overage charges that AT&T is counting to extort from me. Is losing a long-time, well-paying customer (and $240 dollar account receivable) more lucrative than a few extra 20 spots a month AT&T?
No recent posts, but how is PDANet working out? Any new info out there regarding PDANet or other tethering devices that are working?
Here is my issue and I really appreciate if anyone has a solution...
I installed PDAnet to my iPhone then I installed air video to my iPad (as I have a big collection of movies to watch on the go).
My iPad works fine with all Internet apps using PDANet including YouTube but not working on Air Video.
Does anyone know how I make it work??


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Growing up in Pennsylvania, Maura Abeln Smith learned about sacrifice early on. Her father had immigrated from Germany during the Great Depression; her mother entered college when Smith was a child, returning for her master's degree at 65. Smith acknowledges their influence. "I was born to older parents, who worked hard to provide for us," she said. "They were much stricter than my friends' parents."
Although Ann K. Levine graduated from Miami Law 13 years ago, getting into law school is still her top priority. Author of "The Law School Admission Game: Play Like an Expert," and founder of her own consulting firm, Levine has guided more than 2,000 students around the country through the often daunting process of applying to law school.
Devang Desai is as much a Miami local as one could be. Although born 8,000 miles away in Nairobi, Kenya, he attended Miami public schools from an early age and earned two degrees from the University of Miami – one in political science and the other a J.D. And he has cemented a lasting connection to the law school by becoming president of its Law Alumni Association.
With just a few days to go before the start of the Summer Olympic Games in London, Miami Law adjunct professor Jill Pilgrim and Miami Law graduate Claire Zovko are preparing to offer their own perspective on the event and its legal implications.
A 2009 graduate of Miami Law has joined the school's Academic Achievement Program as a full-time academic support advisor and adjunct professor. Alex Schimel, who gained renown while at Miami Law by helping other law students prepare for exams, will join the program's director, Joanne Harvest Koren, in designing and implementing programming to help students acclimate to law school and achieve academic success.
Tina Portuondo moves like a dancer but commands like a CEO. Portuondo, the Director of the University of Miami School of Law's Heckerling Institute on Estate Planning, has been appointed chair of the American Bar Association's Section of Real Property, Trust, and Estate Law, or RPTE.
A resolution that was drafted by two Miami Law students and which condemns domestic violence was unanimously approved Tuesday by the Miami-Dade County Commission.
From a pool of 2,400 nominations, Miami Law's Legal Corps has been selected as a human-rights finalist in the upcoming CLASSY Awards in San Diego, the largest philanthropic prize ceremony in the country.
Miami Law alumnus Adalberto José Jordán swore his oath as a judge for the U.S. Court of Appeals for the Eleventh Circuit in a Miami courtroom packed with friends, colleagues and mentors from the local legal community.
Bidding for employers participating in the Fall Recruiting 2012: Fall OCI Program-Phase I will begin on Friday, July 6 at 9 a.m. EST and will conclude on Thursday, July 12 at 11 p.m. EST.
One of the nation's leading experts on family and matrimonial law, Nancy Chemtob, J.D. '90, is more than an attorney. Chemtob practices in one of the most emotionally complicated and contentious areas of the law. For her clients, she has been a therapist, financial advisor and life coach.
Oswaldo Rossi, J.D. '01, may be tone deaf and have very little rhythm, but that hasn't stopped him from rocking the music industry. Living in Los Angeles and working at the legendary Capitol Records Tower in Hollywood, Rossi is Vice President of Business Affairs for EMI Music North America.
Miami Law alumnus Laird A. Lile, whose practice in Naples, Fla., deals in wills, trusts and estates, received one of only two President's Awards of Merit presented at the annual convention of The Florida Bar in Orlando. During the meeting, Lile also was sworn in for his fourth consecutive two-year term on the Florida Bar's Board of Governors, representing the 20th Circuit.
Aric Williams is an affable and engaging young man with a quick, earnest smile. His infectious personality is serving him well as he mentors local high school students and bats ideas around with University of Miami President Donna E. Shalala. If Hollywood ever makes a movie of Williams' life, the lead role should go to Will Smith.
A group of Miami Law professors in the Robert Traurig-Greenberg Traurig LL.M. in Real Property Development program have created the Charles M. Haar Award for Excellence in Planning and Zoning in memory of the late professor, who died on Jan. 10 at the age of 91. The award is given to a student who earns the highest grade in Adjunct Professor Brian Adler's Planning and Zoning course, and the recipient is designated as the Charles M. Haar Scholar in Planning and Zoning.
Although his day job involves acting as Special Advisor to Dean Patricia D. White at Miami Law and helping to run LawWithoutWalls, Michael Bossone has an additional talent – poetry.
Miami Law's Professional Responsibility and Ethics Program completed the spring semester with a CLE ethics training session for the Cuban American Bar Association. Under the supervision of the program's director, Jan L. Jacobowitz, third-year law students Courtney Daniels, Daniela Torrealba and Charlie Muniz addressed ethical issues faced by lawyers in a technologically advanced age.
The law firm of Ver Ploeg & Lumpkin, P.A. has supported Miami Law's Legal Corps with two donations over the past two years, each of which funded a six-month fellowship with the housing foreclosure project at Legal Services of Greater Miami, Inc.
Burton Young, a marital and family lawyer who graduated from Miami Law in 1967, has received the G. Kirk Haas Humanitarian Award from the Florida Bar for his service to the legal profession. The award recognizes an attorney who has an abiding respect and caring for others.
Need assistance with contacting our world-renowned scholars and former practitioners for commentary? Click here for more information.
View photos of the Miami Law campus, students, events, faculty and many more in our Flickr photo gallery.
View our Miami Law YouTube channel featuring videos covering academics, student life and news from the University of Miami School of Law.


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In Memoriam –
Fred LaRock
On Monday, June 25, this world lost an amazing man. A man with a strong will, sometimes a big scary prescience, and an even bigger heart, a coach of mine for over eight years and friend for over 13, I will miss Fred L. LaRock even more than I may realize yet.
When I was thinking about what I wanted to write, some of the memories I was thinking of haven't been brought up in eight years or more. I'm 25 now, and Fred picked me out of a clumsy group of 12-year-olds to start his ASA softball summer league. I always say to everyone that talks to me about softball, or my youth for that matter, that the summer Fred and I found each other was the summer that changed my life. It was also the summer I fell in a mud puddle trying to impress him and Ron Graves at the Moretown Elementary School field. I didn't even make the catch, and after Fred pulled himself off the ground from laughing so damn hard at me he yelled: "If you're gonna run all that way, you might as well catch it." A line I know so many of his softball players are familiar with, along with my nickname "Puddles," which pretty much stuck with me until I graduated.
I was a pretty crude young lady; he would just call me young though.I don't think he ever thought I was a lady. He would always ask how my weekend was, because more times than not I got myself into trouble and he wanted to hear why and/or how. One year he brought new girls onto our summer team, and I kept them out all night before a game. I never lived that one down and he made us run extra that day, since he knew how much I hated running. After all the yelling and torture, he couldn't wait to hear all the juice I got on the new girls.
My mother says as much as I thank him for making me a great softball player at such a young age, she thanks him for helping her shape my youth. I wasn't the biggest troublemaker around, but I certainly wasn't wearing a halo around my head, and Fred really helped guide me on the right path. He kept me busy in the summer, traveling to tournaments playing ASA ball, then in the spring varsity softball; he even found me a winter indoor league to play on just to keep my skills fresh and my head in the game (both softball and life).
A stickler for the rules and for perfection Fred was and, I think we can all agree, a huge influence in so many lives. I wish I could have given him his first state title, along with so many other things. I wish I could give him back the chest hair I so eagerly plucked from his chest after a very serious conversation he was having with our team, but I can't. And even after all the funny moments and laughs about the memories are had, I still think about how he'll never give me another pep talk, and how he won't be there to brighten my day when I'm sulking or being crabby, which I am and often was when he was my coach.
I used to miss him when he was right in front of me. Imagining him not here is still very hard to do. What's even worse is thinking of all those girls that are 12 and looking for guidance, eager to learn the game of softball, that won't even get to meet him. Now my stories, his spirit and determination are what will live on in all of us. Every time we take a field or watch someone take a field we'll think of him. I smile today because of who I am, and who he helped me become.
Miss you, Ferdie…Give them all hell! And keep an eye on your second baseman… you know how good I am at falling; hopefully you'll catch me a few more times from upstairs.
Samantha K. Seymour
Warren, VT


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|This is one of the simplest breakfast casseroles ever, but the combo of kale and Feta is a winner!
Spike Seasoning and a little salt and fresh ground black pepper.
(Makes 6-8 servings, recipe created by Kalyn.)
10-12 oz. fresh kale, washed and coarsely chopped
2 tsp. olive oil
3/4 cup crumbled Feta cheese (about 4 oz.)
12 eggs, beaten
1 tsp. Spike Seasoning (or use any all-purpose seasoning that's good with eggs)
Salt and fresh-ground black pepper to taste
South Beach Suggestions:
More Tasty Ideas with Kale:
(Recipes from other blogs not always South Beach Diet friendly; check ingredients.)
Roasted Kale Chips with Sea Salt and Vinegar from Kalyn's Kitchen
Sauteed Kale with Garlic and Onion from Kalyn's Kitchen
Red Russian Kale and Red Onion Savory Breakfast Squares from Kalyn's Kitchen
Artichoke, Kale, and Ricotta Pie with Eggs and Parmesan from Kalyn's Kitchen
Goat Cheese, Kale, and Spinach Pasta from Dianasaur Dishes
Quinoa with Sauteed Mushrooms and Kale from Use Real Butter
Sweet Potatoes, Kale, and Sausage from Guilty Kitchen
Baked Rigatoni with Kale from In Good Taste
Dinosaur Kale Salad from Simple Nourished Living
Kale and Toor Dal from Fat Free Vegan Kitchen
(Want even more recipes? I find these recipes from other blogs using Food Blog Search.)


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Saturday, August 2, 2014
Former Berkeley track star Catrina Morrison is about to embark on a great adventure.
In town for the summer, Morrison has been conducting cheerleading camps with some former collegiate cheerleaders. On July 28-30, she filled the Berkeley Middle School auditorim with 68 of her former Stags cheerleaders for a three-day cheer camp.
Working with Berkeley brought back so many memories especially since I was in those girls shoes a few years ago, Morrison said.
While at Berkeley, in addition to being a cheerleader, Morrison and her younger sister LeAnna were the queens of South Carolinas track kingdom, winning multiple team relay and individual championships during their time at Berkeley High School.
While LeAnna went off to run at UNC Charlotte, and now plays basketball, in addition to running track in 2015 at South Carolina, Catrina chose a different route.
She followed her cheerleading dream.
Catrina roamed the football sidelines at Clemsons Death Valley for the past four seasons as a Tiger cheerleader.
I love cheering and loved cheering for Clemson, she said.
In May, Morrisons career at Clemson concluded with a degree as she hung up her orange and purple cheerleading uniform for the final time.
Graduation did not sound the end of Morrisons cheerleading career. Instead, this was just the beginning of her next great adventure.
While waiting to begin work on her masters degree, Morrison spent the summer pursuing her two favorite pastimes by conducting cheerleading camps throughout the Southeast.
This summer I traveled to Florida, Georgia, and North Carolina to teach about 12-to-15 different camps. Its such a fun job because I get to do my two most favorite things in the world, cheering and traveling.
Morrison is a Universal Cheerleaders Association (UCA) instructor. More than 1,500 instructors make up the UCA staff and they are chosen based on skills, personality and their ability to teach.
Instructors travel all over the Southeast to teach cheer camps to high school students, she said. Im very passionate about cheering and also helping other girls to become just as great as I was with cheering in high school and college.
Locally, Morrison is a cheer coach at the new Elite Sports athletic facility in Moncks Corner. She said coaching would be something shed be able to do while she completes her masters degree in Social Work or Clinical Mental Health Counseling.
She is excited about where the road might lead.
Its just the beginning of an exciting life for me, she said. My plans are to work with children that either have behavioral problems such as conduct disorder and oppositional defiant disorder or to work with children who experienced some type of maltreatment whether its sexual, emotional, physical, or psychological.
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Wednesday, January 30, 2013
Don't tell me football isn't fixed.
As if the whole Ray Lewis storyline wasn't enough, someone in the ivory tower that is the NFL executive offices saw a real unique situation brewing.
Throw Peyton, Tom, the whole city of Atlanta, RGIII, Andrew Luck, the Great State of Texas, chuck them all under the bus, and we have us a marketing gold mine here boys.
Brother versus brother. Jim against John. Harbaugh v. Harbaugh. Brilliant!
And in his best Jean Luc Picard voice, NFL Commissioner Paul Goodell said, "Make it so!"
What better way to make football fans forget the New Orleans bounty travesty than by pitting brother against brother? Put mom on TV wearing half a Baltimore Ravens jersey and half a San Francisco 49ers jersey.
Or better yet, make mom a Ravens fan and Dad Niners all the way, baby.
This is the NFL at its best. East Coast vs. West Coast and include everyone in America in between.
Atlanta was supposed to lose last week to Seattle, blowing a 27-point lead to give away the game with 31 seconds on the clock. I had maintained as early as the Seahawks' first touchdown that Seattle would come back and take the lead with 30 seconds left in the game. Despite the conspiracy theory ridicule I nailed it.
They gave the Falcons a token half-minute to mount a last second comeback, which they did.
This threw the NFL's oracles for a loop as they were not expecting Pete Carroll to call timeout as Matt Bryant's 49-yard field goal attempt drifted wide right. But he did and Bryant got another chance, which he nailed.
This week the NFL playmakers left nothing to chance. After coming up short with 1:13 left in the game, the Falcons got the ball back with just 10 seconds left and unless you're Russell Wilson, what can you do with just 10 seconds left on the clock?
Now, what about New England and Baltimore? The number one offense in all the NFL by 100 points does not score a single point in the second half.
CBS commentator Jim Nantz who will call Super Bowl XLVII, already called this a story of Biblical proportions, "This year's Super Bowl will feature the greatest story ever told, the battle of two brothers."
I will not watch this football game. I doubt if I'll watch another NFL football game after this, in fact.
I'm not a fan of any one particular team except maybe the OLD Cleveland Browns but they're the Ravens now.
I feel sorry for the city of Cleveland.
I feel even sorrier for Atlanta. All it did was draw the eternal ire of the NFL for having the audacity to let an ice storm paralyze the city three days before Super Bowl XXXIV.
With the train wreck that was the 1996 Summer Olympics still lingering close in the rearview mirror of sports news, Atlanta hosted an equal train wreck of a Super Bowl in 2000 when nobody could get from Point A to Point B because of the two-inch glaze of ice coating most of Georgia.
Atlanta hasn't hosted one since and its team hasn't come within shouting distance of getting to one either.
How does a team blow such ridiculous leads on consecutive Sundays? It can because this game is fixed.
Just like wrestling.
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If you find a comment that is objectionable, please click "report abuse" and we will review it for possible removal. Please be reminded, however, that in accordance with our Terms of Use and federal law, we are under no obligation to remove any third party comments posted on our website. Read our full terms and conditions.
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This post is part of a weekly series of 'link-up' Posts which reflect on life's journey, old memories and family stories (see below for more info).
What could be more quintessentially childhood-memory-friendly than a trip to the Zoo?!
We recently took the kids to the fabulous Longleat, near Bath, for an amazing day out. It was a day which I am convinced will remain in their memories for many, many years to come. 8 FULL hours of fur, feathers, fins, scales and teeth, resulting in tired legs (and a sprint to the gift shop for some 'tat' before closing…..)
Can you remember your first trip to the Zoo?
My earliest memories of encounters with wild animals (if we exclude my brother) are not particularly joyous. Back in the 70s and 80s they were depressing places where large beasts paced up and down and gorillas smeared their arses up against the perspex barriers, with threatening looks. Nice.
No one ever looked as happy as the faces we saw at Longleat, let me tell ya. The lions always looked like they could use a dose of Bob Martin's and, to be frank, the penguins always gave me the impression that they may have stolen a cafe spoon and were planning to make a bid for freedom via an underground tunnel network. After the stupid kids had fed them the fish at 12pm, that is. Not before.
Things couldn't be more different in 2012 (thank God). The Silverback gorilla lives in his own house on a island. A bit like Richard Branson, but with less celebrity friends. He has been there since 1950-something watching TV. They tried to take it away once, and he apparently went ape-shit (pardon the pun), so they reinstated it. This time he has full plasma, HD Sky TV and loves Sponge Bob Square Pants. I kid thee not. No arse-smearing here, my friends.
Our kids had the time of their lives (except when my 5 year old freaked out as we entered the giant Maze). It was relentless entertainment, and I'd thoroughly recommend it as a day out. Oh, and by the way:-
a) the house is just as fabulous as the zoo
b) the monkeys WILL steal bits of your car
What are your memories of the Zoo as a young 'un? Am I making it sound worse than it really was? Share your memories with us – either write a blog post and link it up (the Linky will stay open for some time yet, so no need to rush), or just share your memories with us in the comments if you prefer – you don't have to have a Blog to play! Everyone welcome here. Consider it therapy. But do tell your friends!
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More about the Life's a Journey weekly memories series.
A selection of other posts from this series:-
Week 2 – Old School Portrait
Week 4 – Bestest Friends
Week 5 – Teenage Crushes
Week 6 – First Movie Memories
Week 9 – Favourite Childhood Books
Week 19 – Becoming a Parent
Week 25 – Old Boyfriends


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- Handcrafted in the USA
- Full-grain leather
- 13" shaft height
- Shaft embroidery
- J-Flex flexible comfort system
- Walking heel
- Broad square toe
- Rubber outsole
Make a statement with these beautiful Bent Rail Cross Western Boots by Justin. Handcrafted in the USA, they are designed with Cross embroidery along its shaft with a distressed finish. They are equipped with the J-Flex comfort system which generates return energy by the leather-covered cushioned insole and triple density insole board. Pair with true denim and a plaid button up for a complete outfit. The removable orthotic insert gives an extra layer of cushioning for extra comfort. Pair with denim shorts and a flowy blouse for a great summer outfit!
Style(s): BRL320, BRL321
Product Reviews for Justin Women's Bent Rail Cross Western Boots
Reviewed by 1 customer
- Cute
- Easy To Clean
- Stylish
- Well Made
- Calf Area Narrow
- Calf Of Boot Very Narrow
- Not True To Color In Phot
Best Uses
- Casual Wear
- Date Night
- Going Out
- Horse shows
- School
- Travel
Comments about Justin Boots Justin Women's Bent Rail Cross Western Boots:
Nice boots and really cute. I can use them for showing stock horse. They could also be nice for going out or with your favorite cowgirl dress. However the color of the tops is dark chocolate not fucia. And the foot is not distressed but a shiny mottled grainy pattern. The sole is leather not rubber. A nice boot but be aware the colors are not the same as in the picture.
- Sizing:
- Feels true to size
- Width:
- Feels true to width


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The WAT is coming along thanks to everyones help!
If your coming from out of town (or live close by) and will be in town Friday night we will be holding a BBQ meet and greet at my house (make sure to send me an e-mail so I can plan!)
It will also give us time to meet and put last min things together for the WAT.
This Friday WDTN (Channel 2 News) Mom2Mom will be taping a story about Preeclampsia and to promote our walk! [:0] I will let everyone know in the area when it will be on TV. [:D][:D][:D]
We are still in need of HELP if you can be of any help such as getting sponsors, donations, refreshments, silent auction items and or bake sale items please let me know![;)]
Thank you everyone for all your support
BUCKEYES you ROCK


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- Philadelphia chromosome (2)
- 32D progenitor cells (1)
- Abl kinase inhibitors (1)
- Allosteric inhibition (1)
- Molecular therapy (1)
- Philadelphia Chromosome-positive leukemia (1)
- Rho GTPases (1)
- acute lymphatic leukemia (1)
- Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia (2013)
- Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase (TK) contributes to the pathogenesis and development of resistance to ABL-TK inhibitors (TKI). The PI3K pathway thus is an attractive therapeutic target in BCR-ABL positive leukemias, but its role in BCR-ABL negative ALL is conjectural. Moreover, the functional contribution of individual components of the PI3K pathway in ALL has not been established. Experimental Design: We compared the activity of the ATP-competitive pan-PI3K inhibitor NVP-BKM120, the allosteric mTORC1 inhibitor RAD001, the ATP-competitive dual PI3K/mTORC1/C2 inhibitors NVP-BEZ235 and NVP-BGT226 and the combined mTORC1 and mTORC2 inhibitors Torin 1, PP242 and KU-0063794 using long-term cultures of ALL cells (ALL-LTC) from patients with B-precursor ALL that expressed the BCR-ABL or TEL-ABL oncoproteins or were BCR-ABL negative. Results: Dual PI3K/mTOR inhibitors profoundly inhibited growth and survival of ALL cells irrespective of their genetic subtype and their responsiveness to ABL-TKI. Combined suppression of PI3K, mTORC1 and mTORC2 displayed greater antileukemic activity than selective inhibitors of PI3K, mTORC1 or mTORC1 and mTORC2. Conclusions: Inhibition of the PI3K/mTOR pathway is a promising therapeutic approach in patients with ALL. Greater antileukemic activity of dual PI3K/mTORC1/C2 inhibitors appears to be due to the redundant function of PI3K and mTOR. Clinical trials examining dual PI3K/mTORC1/C2 inhibitors in patients with B-precursor ALL are warranted, and should not be restricted to particular genetic subtypes.
- The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines (2009)
- Background Imatinib mesylate, a selective inhibitor of Abl tyrosine kinase, is efficacious in treating chronic myeloid leukaemia (CML) and Ph+ acute lymphoblastic leukaemia (ALL). However, most advanced-phase CML and Ph+ ALL patients relapse on Imatinib therapy. Several mechanisms of refractoriness have been reported, including the activation of the Src-family kinases (SFK). Here, we investigated the biological effect of the new specific dual Src/Abl kinase inhibitor AZD0530 on Ph+ leukaemic cells. Methods Cell lines used included BV173 (CML in myeloid blast crisis), SEM t(4;11), Ba/F3 (IL-3 dependent murine pro B), p185Bcr-Abl infected Ba/F3 cells, p185Bcr-Abl mutant infected Ba/F3 cells, SupB15 (Ph+ ALL) and Imatinib resistant SupB15 (RTSupB15) (Ph+ ALL) cells. Cells were exposed to AZD0530 and Imatinib. Cell proliferation, apoptosis, survival and signalling pathways were assessed by dye exclusion, flow cytometry and Western blotting respectively. Results AZD0530 specifically inhibited the growth of, and induced apoptosis in CML and Ph+ ALL cells in a dose dependent manner, but showed only marginal effects on Ph- ALL cells. Resistance to Imatinib due to the mutation Y253F in p185Bcr-Abl was overcome by AZD0530. Combination of AZD0530 and Imatinib showed an additive inhibitory effect on the proliferation of CML BV173 cells but not on Ph+ ALL SupB15 cells. An ongoing transphosphorylation was demonstrated between SFKs and Bcr-Abl. AZD0530 significantly down-regulated the activation of survival signalling pathways in Ph+ cells, resistant or sensitive to Imatinib, with the exception of the RTSupB15. Conclusion Our results indicate that AZD0530 targets both Src and Bcr-Abl kinase activity and reduces the leukaemic maintenance by Bcr-Abl.
- Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism (2012)
- ABSTRACT: BACKGROUND: Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors have been successfully established for the treatment of Ph (+) leukemias. Despite high rates of clinical response, Ph (+) patients can develop resistance against these kinase inhibitors mainly due to point mutations within the Abl protein. Of special interest is the 'gatekeeper' T315I mutation, which confers complete resistance to Abl kinase inhibitors. Recently, GNF-2, Abl allosteric kinase inhibitor, was demonstrated to possess cellular activity against Bcr-Abl transformed cells. Similarly to Abl kinase inhibitors (AKIs), GNF-2 failed to inhibit activity of mutated Bcr-Abl carrying the T315I mutation. METHODS: Ba/F3 cells harboring native or T315I mutated Bcr-Abl constructs were treated with GNF-2 and AKIs. We monitored the effect of GNF-2 with AKIs on the proliferation and clonigenicity of the different Ba/F3 cells. In addition, we monitored the auto-phosphorylation activity of Bcr-Abl and JAK2 in cells treated with GNF-2 and AKIs. RESULTS: In this study, we report a cooperation between AKIs and GNF-2 in inhibiting proliferation and clonigenicity of Ba/F3 cells carrying T315I mutated Bcr-Abl. Interestingly, cooperation was most evident between Dasatinib and GNF-2. Furthermore, we showed that GNF-2 was moderately active in inhibiting the activity of JAK2 kinase, and presence of AKIs augmented GNF-2 activity. CONCLUSIONS: Our data illustrated the ability of allosteric inhibitors such as GNF-2 to cooperate with AKIs to overcome T315I mutation by Bcr-Abl-independent mechanisms, providing a possibility of enhancing AKIs efficacy and overcoming resistance in Ph+ leukemia cells.
- Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I (2012)
- Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase activity. The constitutively activated BCR/ABL-kinase "escapes" the auto-inhibition mechanisms of c-ABL, such as allosteric inhibition. The ABL-kinase inhibitors (AKIs) Imatinib, Nilotinib or Dasatinib, which target the ATP-binding site, are effective in Ph + leukemia. Another molecular therapy approach targeting BCR/ABL restores allosteric inhibition. Given the fact that all AKIs fail to inhibit BCR/ABL harboring the 'gatekeeper' mutation T315I, we investigated the effects of AKIs in combination with the allosteric inhibitor GNF2 in Ph + leukemia. Methods: The efficacy of this approach on the leukemogenic potential of BCR/ABL was studied in Ba/F3 cells, primary murine bone marrow cells, and untransformed Rat-1 fibroblasts expressing BCR/ABL or BCR/ABL-T315I as well as in patient-derived long-term cultures (PDLTC) from Ph + ALL-patients. Results: Here, we show that GNF-2 increased the effects of AKIs on unmutated BCR/ABL. Interestingly, the combination of Dasatinib and GNF-2 overcame resistance of BCR/ABL-T315I in all models used in a synergistic manner. Conclusions: Our observations establish a new approach for the molecular targeting of BCR/ABL and its resistant mutants using a combination of AKIs and allosteric inhibitors.
- p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia (2011)
- BACKGROUND: The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185(BCR/ABL) or the p210(BCR/ABL) fusion proteins are encoded as a result of the translocation, depending on whether a "minor" or "major" breakpoint occurs, respectively. Both p185(BCR/ABL) and p210(BCR/ABL) exhibit constitutively activated ABL kinase activity. Through fusion to BCR the ABL kinase in p185(BCR/ABL) and p210(BCR/ABL) "escapes" the auto-inhibition mechanisms of c-ABL, such as allosteric inhibition. A novel class of compounds including GNF-2 restores allosteric inhibition of the kinase activity and the transformation potential of BCR/ABL. Here we investigated whether there are differences between p185(BCR/ABL) and p210(BCR/ABL) regarding their sensitivity towards allosteric inhibition by GNF-2 in models of Philadelphia chromosome-positive acute lymphatic leukemia. DESIGN AND METHODS: We investigated the anti-proliferative activity of GNF-2 in different Philadelphia chromosome-positive acute lymphatic leukemia models, such as cell lines, patient-derived long-term cultures and factor-dependent lymphatic Ba/F3 cells expressing either p185(BCR/ABL) or p210(BCR/ABL) and their resistance mutants. RESULTS: The inhibitory effects of GNF-2 differed constantly between p185(BCR/ABL) and p210(BCR/ABL) expressing cells. In all three Philadelphia chromosome-positive acute lymphatic leukemia models, p210(BCR/ABL)-transformed cells were more sensitive to GNF-2 than were p185BCR/ABL-positive cells. Similar results were obtained for p185(BCR/ABL) and the p210(BCR/ABL) harboring resistance mutations. CONCLUSIONS: Our data provide the first evidence of a differential response of p185(BCR/ABL)- and p210(BCR/ABL)- transformed cells to allosteric inhibition by GNF-2, which is of importance for the treatment of patients with Philadelphia chromosome-positive acute lymphatic leukemia.
- Targeting the oligomerization of BCR/ABL by membrane permeable competitive peptides inhibits the proliferation of Philadelphia Chromosome positive leukemic cells (2011)
- The BCR/ABL fusion protein is the hallmark of Philadelphia Chromosome positive (Ph+) leukemia. The constitutive activation of the ABL-kinase in BCR/ABL cells induces the leukemic phenotype. Targeted inhibition of BCR/ABL by small molecule inhibitors reverses the transformation potential of BCR/ABL. Recently, we definitively proved that targeting the tetramerization of BCR/ABL mediated by the N-terminal coiled-coil domain (CC) using competitive peptides, representing the helix-2 of the CC, represents a valid therapeutic approach for treating Ph+ leukemia. To further develop competitive peptides for targeting BCR/ABL, we created a membrane permeable helix-2 peptide (MPH-2) by fusing the helix-2 peptide with a peptide transduction tag. In this study, we report that the MPH-2: (i) interacted with BCR/ABL in vivo; (ii) efficiently inhibited the autophosphorylation of BCR/ABL; (iii) suppressed the growth and viability of Ph+ leukemic cells; and (iv) was efficiently transduced into mononuclear cells (MNC) in an in vivo mouse model. This study provides the first evidence that an efficient peptide transduction system facilitates the employment of competitive peptides to target the oligomerization interface of BCR/ABL in vivo.
- Novel role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in adhesion and migration of 32D myeloid progenitor cells (2012)
- Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic hematopoietic progenitor cells (HPC) to fibronectin and migration in a three-dimensional stromal cell model. Here, we identified the Ras GTPase-Activating Protein SH3 Domain-Binding Protein (G3BP) as a target gene of Rho GTPases and analysed its role in regulating HPC motility. Overexpression of G3BP significantly enhanced adhesion of murine 32D HPC to fibronectin and human umbilical vein endothelial cells, increased the proportion of adherent cells in a flow chamber assay and promoted cell migration in a transwell assay and a three-dimensional stromal cell model suggesting a strong impact on the cytoskeleton. Immunofluorescent staining of G3BP-overexpressing fibroblasts revealed a Rho-like phenotype characterized by formation of actin stress fibers in contrast to the Rac-like phenotype of control fibroblasts. This is the first report implicating a role for G3BP in Rho GTPase-mediated signalling towards adhesion and migration of HPC. Our results may be of clinical importance, since G3BP was found overexpressed in human cancers.
- Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARalpha and PLZF/RARalpha (2011)
- Chromosomal translocations can lead to the formation of chimeric genes encoding fusion proteins such as PML/RARalpha, PLZF/RARalpha, and AML-1/ETO, which are able to induce and maintain acute myeloid leukemia (AML). One key mechanism in leukemogenesis is increased self renewal of leukemic stem cells via aberrant activation of the Wnt signaling pathway. Either X-RAR, PML/RARalpha and PLZF/RARalpha or AML-1/ETO activate Wnt signaling by upregulating gamma-catenin and beta-catenin. In a prospective study, a lower risk of leukemia was observed with aspirin use, which is consistent with numerous studies reporting an inverse association of aspirin with other cancers. Furthermore, a reduction in leukemia risk was associated with use of non-steroidal anti-inflammatory drug (NSAID), where the effects on AML risk was FAB subtype-specific. To better investigate whether NSAID treatment is effective, we used Sulindac Sulfide in X-RARalpha-positive progenitor cell models. Sulindac Sulfide (SSi) is a derivative of Sulindac, a NSAID known to inactivate Wnt signaling. We found that SSi downregulated both beta-catenin and gamma-catenin in X-RARalpha-expressing cells and reversed the leukemic phenotype by reducing stem cell capacity and increasing differentiation potential in X-RARalpha-positive HSCs. The data presented herein show that SSi inhibits the leukemic cell growth as well as hematopoietic progenitors cells (HPCs) expressing PML/RARalpha, and it indicates that Sulindac is a valid molecular therapeutic approach that should be further validated using in vivo leukemia models and in clinical settings.
- 5-Lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis (2010)
- Leukotrienes constitute a group of bioactive lipids generated by the 5-lipoxygenase (5-LO) pathway. An increasing body of evidence supports an acute role for 5-LO products already during the earliest stages of pancreatic, prostate, and colorectal carcinogenesis. Several pieces of experimental data form the basis for this hypothesis and suggest a correlation between 5-LO expression and tumor cell viability. First, several independent studies documented an overexpression of 5-LO in primary tumor cells as well as in established cancer cell lines. Second, addition of 5-LO products to cultured tumor cells also led to increased cell proliferation and activation of anti-apoptotic signaling pathways. 5-LO antisense technology approaches demonstrated impaired tumor cell growth due to reduction of 5-LO expression. Lastly, pharmacological inhibition of 5-LO potently suppressed tumor cell growth by inducing cell cycle arrest and triggering cell death via the intrinsic apoptotic pathway. However, the documented strong cytotoxic off-target effects of 5-LO inhibitors, in combination with the relatively high concentrations of 5-LO products needed to achieve mitogenic effects in cell culture assays, raise concern over the assignment of the cause, and question the relationship between 5-LO products and tumorigenesis. Keywords: leukotriene, apoptosis, cell proliferation, mitogenic effects, cytotoxicity
- BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility (2006)
- Background The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9. Depending on the breakpoint on chromosome 22 (the Philadelphia chromosome – Ph+) the derivative 9+ encodes either the p40(ABL/BCR) fusion transcript, detectable in about 65% patients suffering from chronic myeloid leukemia, or the p96(ABL/BCR) fusion transcript, detectable in 100% of Ph+ acute lymphatic leukemia patients. The ABL/BCRs are N-terminally truncated BCR mutants. The fact that BCR contains Rho-GEF and Rac-GAP functions strongly suggest an important role in cytoskeleton modeling by regulating the activity of Rho-like GTPases, such as Rho, Rac and cdc42. We, therefore, compared the function of the ABL/BCR proteins with that of wild-type BCR. Methods We investigated the effects of BCR and ABL/BCRs i.) on the activation status of Rho, Rac and cdc42 in GTPase-activation assays; ii.) on the actin cytoskeleton by direct immunofluorescence; and iii) on cell motility by studying migration into a three-dimensional stroma spheroid model, adhesion on an endothelial cell layer under shear stress in a flow chamber model, and chemotaxis and endothelial transmigration in a transwell model with an SDF-1α gradient. Results Here we show that both ABL/BCRs lost fundamental functional features of BCR regarding the regulation of small Rho-like GTPases with negative consequences on cell motility, in particular on the capacity to adhere to endothelial cells. Conclusion Our data presented here describe for the first time an analysis of the biological function of the reciprocal t(9;22) ABL/BCR fusion proteins in comparison to their physiological counterpart BCR.


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Kaval's Kickoff: Stanford Top 10
What an amazing weekend for the San Jose Earthquakes and soccer here in the Bay Area. A record crowd of 41,028 fans flooded Stanford Stadium on Saturday night to celebrate the beautiful game and their home town team, the Quakes. This was the second largest crowd in all of Major League Soccer (MLS) this season and one of the largest crowds in the history of the League. If anyone had any doubt about the Quakes and our fan base, I hope this historic evening can once and for all put those questions to rest.
The team responded with a valiant effort, especially in the second half and got some amazing goals from Steven Lenhart and Khari Stevenson to gain a 2-2 draw. In order to properly celebrate the spectacle, I wanted to fire up a top ten list to commemorate the epic evening.
Here is the official Dave Kaval Top-10 List of Amazing Moments from the Red Bull-Quakes match at Stanford Stadium.
10) The awesome tifo and unreal energy displayed by the Ultras and Casbah at the match. Leading the whole stadium in the chants of EARTH – QUAKES gave me goose bumps.
9) Seeing thousands and thousands of fans in old Quakes jerseys from both the 2001-2005 Championship era as well as some throwback NASL gear. Folks really represented their colors at the match.
CONCACAF announces Champions League quarterfinal matchups
MIAMI (Friday, October 25, 2013) – The Confederation of North, Central America and Caribbean Association Football (CONCACAF) has confirmed the quarterfinal pairings for the 2013-14 edition of the CONCACAF Champions League, the region's premier competition for clubs, following the completion of Group Stage play last night.
The quarterfinal matchups are as follows:
Deportivo Toluca, MEX (1) vs. San Jose Earthquakes, USA (8)
Cruz Azul FC, MEX (2) vs. Sporting Kansas City, USA (7)
Club Tijuana, MEX (3) vs. LA Galaxy, USA (6)
Deportivo Árabe Unido, PAN (4) vs. LD Alajuelense, CRC (5)
The quarterfinals will be played in a home-and-away format, with the first legs scheduled for March 11-13, and the return legs on March 18-20. The exact schedule will be announced in the coming days.
Teams with the higher seedwill play away first, before returning home for the second leg.
The eight quarterfinalists emerged from an original field of 24, which kicked off group play on August 6, in the quest to crown a new champion following CF Monterrey's three-year reign.
"After a captivating group stage, we are thrilled to reveal the pairings for the quarterfinal round of the CONCACAF Champions League," said CONCACAF General Secretary Enrique Sanz. "Fans across the region can expect plenty of excitement as these eight clubs compete for the Confederation title and a ticket to the FIFA Club World Cupin 2014.
"From Gold Cup, through FIFA World Cup Qualifiers and now in the CONCACAF Champions League, the level of competition in our region has been tremendous this year. It was exciting to see qualifying from all of our various group stages go right down to the wire."
The quarterfinal matchups were determined by a ranking of winners from each of the eight groups, accordingto a formula based on points obtained in the group phase followed by goal differential. The quarterfinal winners will advance to the semifinals.
The full quarterfinal schedule, as well as more information on the CONCACAF Champions League, can be found at CONCACAF.com.
7) Food truck row in the Epicenter Fan Zone was off the hook with thousands of fans sampling everything from BBQ Kalbi to Twisted's tasty frozen yogurt.
6) The jumper's helmet cam broadcast live on the videoboard as they descended toward the stadium. It looked like that huge American flag connected to the second jumper practically touched the masses of fans as he swooped down to land on the field. That was awesome.
Recap: Quakes 2, FC Dallas 1
Walter Martinez and Chris Wondolowski each scored a goal to help MLS original Ramiro Corrales go out a winner in the final game of his career, and the San Jose Earthquakes topped FC Dallas 2-1 on Saturday in the season finale for both teams.
The win – and an emotional send off for Corrales in the 71st minute – eased at least some disappointment for the Quakes, who were still eliminated from postseason contention in favor of the Colorado Rapids.
Martinez, who made his MLS debut in May, scored his second goal of the season for the Earthquakes, who needed to score 13 goals and to have the Rapids lose on Sunday in order to return to the playoffs.
Wondolowski scored his team-leading 11th goal of the season in the second half.
Stephen Keel scored in stoppage time for Dallas, who also said goodbye to a club regular in head coach Schellas Hyndman, who announced earlier this month that he will step down at the end of the season after six years on the job.
Martinez missed a shot high to the top left corner in the early going, but came back in the 27th minute to give the Earthquakes a 1-0 edge.
Justin Morrow sent a forward pass along the left sideline, where Martinez picked it up and played a dangerous cross that skipped past Dallas goalkeeper Chris Seitz, who was caught going for Steven Lenhart's dummy run in front of the goal.
Wondolowski added his goal, a sharp drive in the upper right corner, in the 57th minute. He was assisted by Lenhart and Shea Salinas.
Corrales, making his first start since Sept. 14, had two good scoring chances in the first 11 minutes. He missed wide right in the fifth minute and again in the 11th minute.
The last original remaining MLS player from 1996, Corrales received a standing ovation from the crowd when he was introduced. A special ceremony, featuring a video tribute from players around the league, was held before kickoff.
Corrales played 250 games for the Earthquakes, the most in team history by nearly 80 games.
Corrales received another standing ovation when he was subbed out of the game in the 71st minute, and Lenhart and Victor Bernandez punctuated the moment by carrying him off the field on their shoulders.
4) Honoring the 1994 World Cup players from the United States National Team at halftime, especially the 30 for 30 style video recounting that historic day 17 years ago when Stanford Stadium played host to 84,000-plus fans to see the US narrowly lose to the eventual World Cup Champion Brazil 1-0.
3) Jon Busch making quite frankly one of the best saves ever in the 83rd minute and the crowd gasping at the enormity of the athletic diving play.
2) Two words: The Wave.
I would like to thank all our loyal fans who attended the match and made history this weekend. We could not do it without your tremendous support. I would also like to thank Stanford University for hosting us and providing such a beautiful venue for such a great community event.
Dave Kaval
San Jose Earthquakes


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Hi everyone. When will I get over this guilt? I woke up early this morning and ended up in tears thinking about all of the things that we could have done differently, wondering if doing those things differently would have saved Gracie.
The biggest thing I've been killing myself with is wondering if I should have gone on hospital bedrest. Dh and I opted to have me rest at home when we found out she had IUGR and placenta issues. He did everything for me. I was hardly up on my feet, only to shower and use the bathroom. I keep thinking, what if I had just been hospitalized then? Would it have saved her? Would it somehow have kept my liver enzymes from going up? Would I not have had protein in my urine? Could they have monitored me more closely and kept me pregnant longer? Would demanding steroids have made the difference?
I'm so mad at myself.


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Updated Jan 10, 2013 - 2:24 pm
Chandler brewery unleashes 'Sex Panther' in stores
CHANDLER, Ariz. -- Inspired by a scene from the movie "Anchorman," the San Tan Brewing Company has put "Sex Panther" in Valley stores by the six pack.
San Tan Brewmaster Anthony Canecchia said he had the double chocolate porter brewed well before he came up with the name. And then it clicked.
"We were all sitting around and had the recipe and Aaron Sanchez suggested the name because we were watching the movie," he said.
The double chocolate porter had been available only on draft, but now is available in six pack cans at Total Wine, BevMo, Whole Foods and some other locations.
And unlike the clip from the Anchorman movie, Sex Panther Beer does not contain real panther in it.
"But it's still good," Canecchia said.


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By Greg Land, Daily Report
Massage Therapist Gets 25 Years for Assault; Massage Company Faces Suit
A Fulton County judge has sentenced a former massage therapist to 25 years in prison following his conviction for aggravated sexual battery.
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OER#691-3967980Kick Panel Vacuum Actuator Cover
Quality injection molded reproduction of the original kick panels. Will fit and install on models originally equipped with or without air conditioning. Each reproduction kick panel includes the correct vent assembly with functional black pull knobs. Available in black only. Each panel can be painted to the desired color.