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Saunders hopes for first win as Wolves face fellow strugglers Barnsley
A busy Championship programme on Tuesday night serves up a crucial game in the battle to avoid relegation and a chance for Cardiff City to edge closer to the Premier League.
Blackburn Rovers and Millwall will turn their focus back to the league after reaching the FA Cup quarter-finals over the weekend, while Mark Robins takes charge of his first Championship fixture as Huddersfield Town manager.
Dean Saunders has yet to win in six games as Wolves boss and knows defeat at Barnsley will drop his team into the bottom three. Barnsley, who reached the last eight of the FA Cup by knocking out MK Dons, are on a five-match winning streak in all competitions.
Cardiff are on a nine-game unbeaten run in the league and the leaders will be targeting a 14th win from 16 home games when Brighton & Hove Albion visit South Wales.
Hull City are Cardiff's closest challengers, eight points adrift of the summit, and Steve Bruce's side entertain a Blackburn team hoping to build on their shock cup triumph over Arsenal.
Click below for individual match stats and previews:Barnsley v Wolves
Birmingham v Sheff Wed
Burnley v Middlesbrough
Cardiff v Brighton
Derby v Bolton
Hull v Blackburn
Ipswich v Watford
Leicester v Charlton
Millwall v Peterborough
Nottm Forest v Huddersfield
Crystal Palace v Bristol City
Ipswich Town have won their last two home games, but take on a Watford side with the best away record in the division after thrashing Birmingham City 4-0 at the weekend.
Crystal Palace inched up to fourth after hammering Middlesbrough on Saturday and will be confident of another three points against lowly Bristol City, who have lost their last four away games.
Fifth-placed Leicester City have won three games in a row at home and welcome former Foxes defender Chris Powell's Charlton Athletic team to the King Power Stadium.
Middlesbrough are clinging to the final play-off position, despite losing six of their last seven games, and will hope for a change of luck at inconsistent Burnley.
Bottom club Peterborough United have lost only one of their last five matches and travel to Millwall, who have lost four on the spin in the league and have won just once in nine games.
Billy Davies is waiting for his first win since returning to Nottingham Forest and his side face Huddersfield, who lost 4-1 to Wigan Athletic in the FA Cup on Sunday in Robins' first match at the helm.
Bolton Wanderers have not won away since November and travel to Derby County, while Sheffield Wednesday have lost once in 10 matches ahead of their trip to Birmingham.


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The new Google Earth plug-in for the browser has been out for a week now. Whilst I was away on a personal jaunt to Geneva developers have been working hard adapting their Google Maps to showcase Google Earth's amazing features. Here are some of the best maps we have have found so far:
Google Earth Hacks
Google Earth Hacks has added an option to view their collection of over 20,000 satellite views with the Google Earth browser plug-in. If you are interested in viewing the world in 3d and with Google Earth's amazing terrain feature Google Earth Hack's huge collection would be a great place to start.
On a different topic Google Earth Hacks also now have a Street View Collection featuring interesting finds submitted by readers.
See Bournemouth
See Bournemouth is an example of the Google Earth Browser being used in conjunction with Wikipedia articles and Panoramio photos. You can even search the map for hotels in Bournemouth, UK.
ArcGIS JavaScript Example
The Flex RIA blog has produced an interesting example that uses ArcGIS JavaScript to add a polygon area to any clicked point showing the area that is within a 3 minute driving time of that point.
TravelPod have also added the Google Earth plug-in so that travellers can now follow travel blogs in 3D. The link above takes you to Lucky's trip across South America.
Bouncing Earth
James Stafford's 3d animation of a bouncing Earth within a Google Earth Browser map is amazing. This example proves that 3d animations are possible with the new browser plug-in which should open up whole new realms of possibilities. 3d models of vehicles moving in real-time as they are tracked in Google Maps is just one idea that springs to mind.
Via: Google Earth Blog
The Google Earth Blog also has a post on a number of other examples using the new Google Earth plug-in called Plug-in Links.
Ogle Earth has a post on the same subject Early adopters of the Google Earth Plug-in. The post also includes a number of interesting examples.

subset: commoncrawl


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Vote For Your Favorite Discontinued Red Robin Burger To Get It Back on the Menu
Red Robin is asking customers to vote for their favorite Red Robin burgers from the past in their campaign Bring My Burger Back. Out of the ten choices, the burger that gets the most votes by December 6 will be brought back to the menu next year. To remind you to vote, each day you vote you're automatically entered to win one of two $50 gift certificates.
Love hamburgers? Then you'll Like AHT on Facebook! And go follow us on Twitter while you're at it!


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Newbies, Post in Welcome Central to open up the boards
0 Members and 1 Guest are viewing this topic.
Darkness will be "poured out" on the kingdom of the beast. God "wraps Himself with thick darkness." "Darkness is His secret place." Similar to what a laser light is to ordinary light, thick darkness is to ordinary darkness. It is now thought that maybe 95% of the substance in this universe is dark energy and dark matter. The Concordant Literal has: "These are waterless springs, and mists driven by a storm, for whom the gloom of darkness has been kept." 2 Peter 217 Nothing about forever and it is the "gloom of darkness," not the men that, "has been kept." In a similar writing, the book of Jude in verse 6 (of the same Version) has: "...messengers who keep not their own sovereignty, but leave their own habitation, He has kept in imperceptible bonds under gloom for the judging of the great day." "The darkness and the light are alike unto Thee."
My thinking was this mist of darkness is hell or Hades for the dead. But the verse says it is reserved forever. Is this a mistranslation as to the same as the book of revelation, concerning the lake of fire.


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Yoga Clutch
Item# 05-60552_2
Stylish and functional clutch constructed with yoga mat material
Fill with your essentials, toss in your yoga mat bag, and you're ready to go! Creatively crafted from yoga mat material featuring a full zip closure. Made in China.
Yoga Clutch Features:
- Keeps your essentials all in one place
- Full zip closure
- Made exclusively by Gaiam
8.25"L x 4.5"W
Wipe clean with a damp cloth.
Rated 5 out of 5 by 2 reviewers.
Rated 5 out of 5 by Tanya628 Handy This could be used for so many little things and it is cute! I intended to use it for my key's and money, but I ended up using it to keep my electronics (cell phone charge, head phones) all in one spot in my luggage bag. June 18, 2014
Rated 5 out of 5 by khigh Super Cute! I use this in my purse to carry smaller items that I need to keep all together, It's a great little bag to use for makeup, medication, jewelry etc in a purse or gym bag or suitcase. Love that it's made up of yoga mat scraps- such a fun way to be green and eco-friendly! February 26, 2014
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What are the dimensions?
1 year, 9 months ago
Bethany, CT
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Answer:The Yoga Clutch is 4.5"x8.25"x.5". It's perfect for carrying your phone, keys, and smaller personal items to class or on the go!
1 year, 9 months ago
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Robyn Metallic Trim Suede Sandal
Style # 204280
Talk about dark glamour. This pair of bebe sandals feature soft suede and leather paneled structure finished by gold trim. Structured platform builds height and allows for more comfort. Try it with a pair of coated denim and a sheer black top.
- Suede upper, synthetic outsole.
- Heel height: 5.5" (14 cm) with 1.5" (4 cm) platform.
- Imported.


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Gear Sale
F-One Trust 2015 Kitesurfing Kite, (with optional Board, 15% discount)TRUST 2015 is now built with the same TECHNOFORCE double ripstop fabric used on the BANDIT, same construction, and equipped with the same MONOLITH bar. Small modifications on the shape are making it now an excellent freeride kite for all riders, not only beginners, while keeping its legendary stability and relaunch abilities. More than ever, the TRUST will be the best fit for riders who don't want a fast and high performance kite like the Bandit. The TRUST gives high confort and confidence, constant pull and less speed than the Bandit, being very easy to jump with with crazy hangtime. Learn More$1,019.00
FOne Kiteboarding Package: Trust Kite Complete, Pump, 2014 Next Twin Tip Board, Optional HarnessWith this package, you get the top notch F-One quality and performance at a great price, including a free pump. This is the best bang for the buck, you save up to 10% over retail if you buy the kite and the board separately !! Learn More
Regular Price: $2,161.00
Special Price $1,728.80


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First, it's a very nice looking stand. I'd love one.
But, am I being asked to be an investor? For my $69.00 I "might" get a stand "if" the project is fully funded? Otherwise, I'm out 69 bucks? And why the deadline? So on December 21st it's dead?
I think the product stands (no pun intended) for itself. Go out and pitch the product, get it into stores, present it to investors. If it's worthy, someone will fund it. Go on Shark Tank!
Great product though. Good luck to you.


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Sky Sports News Radio host Mikey Burrows kicks off the brand new Premier League season in the hosts' hot-seat and is joined in the studio by TEAMtalk.com Deputy Editor James Marshment and Sky Sports.com's feature writer Adam Bate.
The trio get stuck straight into Manchester City masterclass on Monday Night Football as the Manuel Pellegrini era begun with a 4-0 destruction of Newcastle.
Marshy believes City made a title statement with the performance, and tears a strip off both Alan Pardew and his under-performing Newcastle players. He also mocks Arsenal's attempts to sign Yohan Cabaye and says the Gunners would be far better trying to tempt the Magpies to part with star keeper Tim Krul.
Pellegrini wasn't the only new manager to get off to a flyer and Bate stresses why he believes David Moyes' Manchester United will be the team to beat this season.
Marshy also waxes lyrical about the performance of Danny Welbeck and reveals a tasty little bet which has been placed in the office over the United and England striker.
Arsenal's transfer market failures also come under scrutiny, with Marshment and Bate debating a make-or-break fortnight ahead for the Gunners and their under-fire manager Arsene Wenger.
Rickie Lambert's World Cup prospects, the chances of all three Premier League new boys going down and Liverpool's top-four hopes are all also discussed.
If you want to listen to the Podcast as an MP3 file click here.
You can also access the Podcast on iTunes.
If you want to get a mention on the next Football Podcast, send a tweet to @TEAMtalk with the hashtag #ilovethepodcast - and you may be one of the lucky ones selected.


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|Mice homozygous for this targeted mutation die in utero from an apparent failure to produce erythrocytes in the liver. Heterozygous mice develop pituitary tumors by 8 months of age.
Former Names 129S-Rb1tm1Tyj/J (Changed: 02-JAN-09 ) 129S3/-etc (Changed: 15-DEC-04 ) Type Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Dr. Tyler Jacks, Massachusetts Institute of Technology
white-bellied agouti
Related Genotype: Aw/Aw
Mice homozygous for this targeted mutation die in utero, apparently from a failure to produce erythrocytes in the liver, demonstrating that the endogenous gene is essential for normal development. Heterozygous mice, which are analogous to human carrier individuals, do not develop retinal tumors, but do develop pituitary tumors by 8 months of age.
This mutant strain was developed in the laboratory of Dr. Tyler Jacks at the Center for Cancer Research at the Massachusetts Institute of Technology. The 129-derived D3 ES cell line was used.
|Wild-type from the colony
|002448 129S1/SvImJ
|Considerations for Choosing Controls
Strains carrying Rb1tm1Tyj allele
002102 B6.129S2-Rb1tm1Tyj/J 002546 C3Ou.129S2-Rb1tm1Tyj/J 002900 FVB.129S2(B6)-Rb1tm1Tyj/JView Strains carrying Rb1tm1Tyj (3 strains)Strains carrying other alleles of Rb1
008186 B6;129-Rb1tm3Tyj/J 026229 STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/JView Strains carrying other alleles of Rb1 (2 strains)
New 129 Nomenclature Bulletin
View Related Disease (OMIM) TermsRelated Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.Bladder Cancer (RB1)
Osteogenic Sarcoma (RB1)
Retinoblastoma; RB1 (RB1)
Small Cell Cancer of the Lung (RB1)
View Mammalian Phenotype TermsMammalian Phenotype Terms provided by MGIassigned by genotype
Rb1tm1Tyj/Rb1+involves: 129S2/SvPas
- mortality/aging
- partial postnatal lethality
- mice develop pituitary gland tumors with a mean survival of 400 days (MGI Ref ID J:215358)
- tumorigenesis
- increased pituitary gland tumor incidence
- mice develop pituitary gland tumors with a mean survival of 400 days (MGI Ref ID J:215358)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.
Rb1tm1Tyj/Rb1+involves: 129S2/SvPas * C57BL/6
- mortality/aging
- premature death
- all heterozygous mutant mice die between 8.5 and 13.9 months of age (MGI Ref ID J:81082)
- tumorigenesis
- *normal* tumorigenesis
- increased pituitary gland tumor incidence
- at autopsy, heterozygotes with severe wasting symptoms show large pituitary adenocarcinomas (~ 6 mm in diameter) (MGI Ref ID J:2511)
- consistent with the "two-hit" model proposed by Knudson, such pituitary tumors are shown to arise from cells in which the wild-type allele is absent (MGI Ref ID J:2511)
- heterozygotes develop intermediate lobe pituitary tumors (MGI Ref ID J:81082)
- increased thyroid tumor incidence
- 23/27 heterozygotes show c-cell thyroid tumors (MGI Ref ID J:81082)
- growth/size/body region phenotype
- cachexia
- at 8-10 months of age, a number of heterozygotes display severe wasting (MGI Ref ID J:2511)
Rb1tm1Tyj/Rb1+involves: 129S2/SvPas * C57BL/6J
- mortality/aging
- premature death
- median lifespan is 372 days compared to 546 days for Men1tm1.1Ctre heterozygotes (MGI Ref ID J:133299)
- tumorigenesis
- increased lung tumor incidence
- in 60% of mice (MGI Ref ID J:133299)
- increased metastatic potential
- 60% of mice exhibit lung metastasis (MGI Ref ID J:133299)
- increased pheochromocytoma incidence
- in 40% of mice (MGI Ref ID J:133299)
- increased pituitary adenohypophysis tumor incidence
- increased pituitary melanotroph tumor incidence
- all mice exhibit tumors of the pituitary intermediate lobe (MGI Ref ID J:133299)
- increased thyroid C-cell carcinoma incidence
- all mice exhibit metastic thyroid C-cell carcinomas (MGI Ref ID J:133299)
Rb1tm1Tyj/Rb1+involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
- mortality/aging
- premature death
- median survival is 47 weeks (MGI Ref ID J:175625)
- tumorigenesis
- increased pituitary gland tumor incidence
- in 9 of 10 mice; 5 of 5 with intermediate lobe origins (MGI Ref ID J:175625)
- increased thyroid tumor incidence
- in 8 of 10 mice (MGI Ref ID J:175625)
Rb1tm1Tyj/Rb1tm1Tyjinvolves: 129S2/SvPas
- mortality/aging
- complete embryonic lethality during organogenesis
- live homozygotes are rarely recovered at E15.5 and never at E16.5 (MGI Ref ID J:105548)
- hematopoietic system phenotype
- abnormal erythropoiesis
- significant decrease in the percentage of enucleated erythrocytes, indicating defective erythrocyte maturation (MGI Ref ID J:105548)
- abnormal macrophage differentiation
- fetal liver macrophages exhibit defects in differentiation, as indicated by small size, lack of extensive cytoplasmic projections, and weak staining for a mature macrophage marker (MGI Ref ID J:105548)
- increased nucleated erythrocyte cell number
- at E13.5, peripheral blood smears contain predominantly nucleated erythrocytes (MGI Ref ID J:81643)
- liver/biliary system phenotype
- liver hypoplasia
- at E13.5 liver cellularity is decreased and the level of apoptosis is increased (MGI Ref ID J:81643)
- nervous system phenotype
- abnormal dorsal root ganglion morphology
- detect ectopic mitosis and apoptosis in the dorsal root ganglia (MGI Ref ID J:105548)
- abnormal fourth ventricle morphology
- detect ectopic mitosis and apoptosis in the intermediate zones of the fourth ventricle (MGI Ref ID J:105548)
- abnormal neuron differentiation
- at E13.5, proliferation is increased in the brain, dorsal root ganglia, and trigeminal ganglia (MGI Ref ID J:81643)
- abnormal third ventricle morphology
- detect ectopic mitosis and apoptosis in the intermediate zones of the third ventricle (MGI Ref ID J:105548)
- abnormal trigeminal ganglion morphology
- detect ectopic mitosis and apoptosis in the trigeminal ganglia (MGI Ref ID J:105548)
- increased neuron apoptosis
- at E13.5, apoptosis is increased in the brain, dorsal root ganglia, and trigeminal ganglia (MGI Ref ID J:81643)
- vision/eye phenotype
- abnormal lens development
- at E13.5, ectopic proliferating cells are seen in the interior of the lens and increased apoptosis is seen (MGI Ref ID J:81643)
- abnormal lens fiber morphology
- increased lens fiber apoptosis
- apoptosis is detected in the lens fiber compartment that is not seen in wild-type (MGI Ref ID J:105548)
- homeostasis/metabolism phenotype
- hypoxia
- expression of hypoxia-inducible genes is increased in the central nervous system at E13.5 (MGI Ref ID J:81643)
- cellular phenotype
- abnormal cell cycle
- MEFs exhibit an increase in the fraction of cells in the S and G2/M phases of the cell cycle (MGI Ref ID J:105548)
- abnormal cell cycle checkpoint function
- MEFs fail to efficiently trigger G1/S cell cycle arrest in response to DNA damage (MGI Ref ID J:105548)
- abnormal macrophage differentiation
- fetal liver macrophages exhibit defects in differentiation, as indicated by small size, lack of extensive cytoplasmic projections, and weak staining for a mature macrophage marker (MGI Ref ID J:105548)
- abnormal neuron differentiation
- at E13.5, proliferation is increased in the brain, dorsal root ganglia, and trigeminal ganglia (MGI Ref ID J:81643)
- increased fibroblast proliferation
- MEFs cultured at confluence exhibit an increase in cell proliferation compared to wild-type MEFs (MGI Ref ID J:105548)
- increased lens fiber apoptosis
- apoptosis is detected in the lens fiber compartment that is not seen in wild-type (MGI Ref ID J:105548)
- increased neuron apoptosis
- at E13.5, apoptosis is increased in the brain, dorsal root ganglia, and trigeminal ganglia (MGI Ref ID J:81643)
- embryogenesis phenotype
- abnormal placenta labyrinth morphology
- abnormal placental transport
- exhibit defective placental transport as indicated by a 7.2% reduction of the essential fatty acid linoleic acid, arachidonic acid and docosahexaenoic acid in E14.5 embryos relative to wild-type (MGI Ref ID J:105548)
- decreased embryo size (MGI Ref ID J:105548)
- growth/size/body region phenotype
- decreased embryo size (MGI Ref ID J:105548)
- immune system phenotype
- abnormal macrophage differentiation
- fetal liver macrophages exhibit defects in differentiation, as indicated by small size, lack of extensive cytoplasmic projections, and weak staining for a mature macrophage marker (MGI Ref ID J:105548)
- integument phenotype
- pallor (MGI Ref ID J:105548)
Rb1tm1Tyj/Rb1tm1Tyjinvolves: 129S2/SvPas * C57BL/6
- mortality/aging
- complete lethality throughout fetal growth and development (MGI Ref ID J:81082)
- homozygous mutant embryos die between E14.5 and E15.5 (MGI Ref ID J:2511)
- hematopoietic system phenotype
- abnormal erythrocyte morphology
- in vitro, mutant erythroid precursors fail to reach end-stage differentiation: small hemaglobinized colonies from mutant mice are pale and contain increased numbers of small late normoblast-like cells instead of enucleated (mature) erythrocytes (MGI Ref ID J:2511)
- similarly, mutant large erythroid colonies are pale, with <5% enucleated erythrocytes relative to wild-type (45%) (MGI Ref ID J:2511)
- abnormal erythropoiesis
- at E13.5, homozygotes display impaired definitive erythropoiesis and fail to produce sufficient numbers of mature erythrocytes, resulting in hypoxia and eventually death (MGI Ref ID J:2511)
- low mean erythrocyte cell number
- at E13.5, wild-type embryos contain on average 45% enucleated, definitive erythrocytes; in contrast, mutant embryos only contain 6.8% enucleated cells (MGI Ref ID J:2511)
- anemia
- at E13.5, homozygotes are severely pale relative to wild-type embryos (MGI Ref ID J:2511)
- liver/biliary system phenotype
- abnormal liver morphology
- at E13.5, mutant livers appear lacy and largely acellular; in contrast, wild-type livers are densely packed with cells (90% of which are of erythroid lineage) (MGI Ref ID J:2511)
- small liver
- at E13.5, homozygotes display a slight reduction in liver size (MGI Ref ID J:2511)
- homeostasis/metabolism phenotype
- pericardial edema
- at E13.5, homozygotes display significant edema, particularly in the pericardial space (MGI Ref ID J:2511)
- skin edema
- cardiovascular system phenotype
- pericardial edema
- at E13.5, homozygotes display significant edema, particularly in the pericardial space (MGI Ref ID J:2511)
- nervous system phenotype
- *normal* nervous system phenotype
- normal numbers of primary neurospheres are produced from cultured E10 telencephalic neuroepithelia (MGI Ref ID J:92520)
- increased neuron apoptosis
- at E12.5, mutant embryos exhibit increased neuronal apoptosis in the spinal cord, dorsal root ganglia and parts of the hindbrain (MGI Ref ID J:2511)
- neuronal cell death occurs prior to the manifestation of the erythropoietic defect, and does not appear to be a secondary effect of anemia-induced hypoxia (MGI Ref ID J:2511)
- vision/eye phenotype
- *normal* vision/eye phenotype
- at 13.5 dpc, homozygotes display normal retinal development at E13.5, homozygotes display normal retinal development (MGI Ref ID J:2511)
- cellular phenotype
- increased apoptosis
- at E13.5, TUNEL analysis indicates a significant increase in apoptotic nuclei throughout the mutant nervous system (esp. dorsal ganglia), in skeletal muscle precursor cells (e.g. tongue myoblasts), lens, and to a lesser extent in liver (MGI Ref ID J:37145)
- in contrast, no significant increase in apoptosis is noted in the mutant lung or cardiac muscles (MGI Ref ID J:37145)
- increased neuron apoptosis
- at E12.5, mutant embryos exhibit increased neuronal apoptosis in the spinal cord, dorsal root ganglia and parts of the hindbrain (MGI Ref ID J:2511)
- neuronal cell death occurs prior to the manifestation of the erythropoietic defect, and does not appear to be a secondary effect of anemia-induced hypoxia (MGI Ref ID J:2511)
- increased cell proliferation
- MEFs largely fail to arrest in response to confluent growth and ~40% of the cells enter S phase (MGI Ref ID J:81082)
- behavior/neurological phenotype
- hunched posture
- at E13.5, 7 of 8 homozygotes display a hunchback posture (MGI Ref ID J:37145)
- skeleton phenotype
- abnormal cartilage morphology
- at E13.5, 7 of 8 homozygotes display a reduced cartilaginous frame (perichondrium) relative to wild-type mice (MGI Ref ID J:37145)
- integument phenotype
- skin edema
Rb1tm1Tyj/Rb1tm1Tyjinvolves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
- mortality/aging
- complete embryonic lethality (MGI Ref ID J:175625)
- cellular phenotype
- abnormal cell differentiationView Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Rb1tm1Tyj related
Apoptosis Research
Endogenous Regulators
Cancer Research
Increased Tumor Incidence
Other Tissues/Organs
Other Tissues/Organs: pituitary
Tumor Suppressor Genes
pituitary tumors
Developmental Biology Research
Internal/Organ Defects
Hematological Research
Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
Intracellular Signaling Molecules
Internal/Organ Research
Liver Defects
|Allele Symbol
|Allele Name
|targeted mutation 1, Tyler Jacks
|Allele Type
|Targeted (Null/Knockout)
|Common Name(s)
|Rb-; Rb1-; Rbx3t; pRb-;
|Mutation Made By
|Dr. Tyler Jacks, Massachusetts Institute of Technology
|Strain of Origin
|ES Cell Line Name
|ES Cell Line Strain
|Gene Symbol and Name
|Rb1, retinoblastoma 1
|Gene Common Name(s)
|OSRC; PPP1R130; RB; Rb-1; p105-Rb; pRb; pp110;
|General Note
|This is one of several targeted null mutations of Rb1 that have been created. Results appear to be similar for all the mutations (J:2498, J:2511, J:2516). Heterozygotes for the mutations show no predisposition to retinoblastoma. Homozygotes die in utero with neuronal and hematopoietic system abnormalities. Transfer of a human RB1 mini-transgene into the mutant mice corrects the defects (J:2516). On the other hand, transfer of the human gene into mice with a normal Rb1 genotype, causing overexpression of the gene product, produces mice dwarfed in proportion to the number of extra RB1 copies they carry (J:15042).Homozygous Rb1tm1Tyj mutant mice given a transgene producing low levels of Rb1 product survive to birth, but die at that stage due tofailure of myogenesis. Myoblasts undergo massive apoptosis, and surviving cells do not undergo terminal differentiation (J:37145).
|Molecular Note
|A PGK-neomycin resistance cassette replaced part of intron 3 and introduced three nucleotide changes into exon 3, creating two termination codons and a new PstI site. The authors predict translation of a truncated protein by the mutant allele. Immunoblotanalysis of E12.5 brain did not detect full length RB1 protein in homozygous mice. [MGI Ref ID J:2511]
Genotyping ProtocolsNEOTD (Generic Neo), Standard PCR
Rb1tm1Tyj, Separated PCR
Helpful LinksGenotyping resources and troubleshooting
Jacks T; Fazeli A; Schmitt EM; Bronson RT; Goodell MA; Weinberg RA. 1992. Effects of an Rb mutation in the mouse [see comments] Nature 359(6393):295-300. [PubMed: 1406933] [MGI Ref ID J:2511]
MacPherson D; Sage J; Crowley D; Trumpp A; Bronson RT; Jacks T. 2003. Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol 23(3):1044-53. [PubMed: 12529408] [MGI Ref ID J:81643]
Macleod KF; Hu Y; Jacks T. 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J 15(22):6178-88. [PubMed: 8947040] [MGI Ref ID J:37025]
Novitch BG; Mulligan GJ; Jacks T; Lassar AB. 1996. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol 135(2):441-56. [PubMed: 8896600] [MGI Ref ID J:36067]Rb1tm1Tyj related
Ajioka I; Martins RA; Bayazitov IT; Donovan S; Johnson DA; Frase S; Cicero SA; Boyd K; Zakharenko SS; Dyer MA. 2007. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell 131(2):378-90. [PubMed: 17956737] [MGI Ref ID J:130181]
Almeida MQ; Muchow M; Boikos S; Bauer AJ; Griffin KJ; Tsang KM; Cheadle C; Watkins T; Wen F; Starost MF; Bossis I; Nesterova M; Stratakis CA. 2010. Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling. Hum Mol Genet 19(8):1387-98. [PubMed: 20080939] [MGI Ref ID J:158372]
Andreu-Vieyra C; Chen R; Matzuk MM. 2008. Conditional deletion of the retinoblastoma (rb) gene in ovarian granulosa cells leads to premature ovarian failure. Mol Endocrinol 22(9):2141-61. [PubMed: 18599617] [MGI Ref ID J:138319]
Andreu-Vieyra C; Chen R; Matzuk MM. 2007. Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice. Endocrinology 148(8):3837-49. [PubMed: 17510234] [MGI Ref ID J:123844]
Bajenaru ML; Donahoe J; Corral T; Reilly KM; Brophy S; Pellicer A; Gutmann DH. 2001. Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia 33(4):314-23. [PubMed: 11246230] [MGI Ref ID J:80411]
Baker DJ; Jin F; Jeganathan KB; van Deursen JM. 2009. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 16(6):475-86. [PubMed: 19962666] [MGI Ref ID J:155824]
Bakkar N; Wang J; Ladner KJ; Wang H; Dahlman JM; Carathers M; Acharyya S; Rudnicki MA; Hollenbach AD; Guttridge DC. 2008. IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis. J Cell Biol 180(4):787-802. [PubMed: 18299349] [MGI Ref ID J:135692]
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Yang H; Williams BO; Hinds PW; Shih TS; Jacks T; Bronson RT; Livingston DM. 2002. Tumor suppression by a severely truncated species of retinoblastoma protein. Mol Cell Biol 22(9):3103-10. [PubMed: 11940667] [MGI Ref ID J:75738]
Zacksenhaus E; Jiang Z; Chung D; Marth JD; Phillips RA; Gallie BL. 1996. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev 10(23):3051-64. [PubMed: 8957005] [MGI Ref ID J:37145]
Zhang J; Gray J; Wu L; Leone G; Rowan S; Cepko CL; Zhu X; Craft CM; Dyer MA. 2004. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet 36(4):351-60. [PubMed: 14991054] [MGI Ref ID J:109491]
Zhang J; Schweers B; Dyer MA. 2004. The first knockout mouse model of retinoblastoma. Cell Cycle 3(7):952-9. [PubMed: 15190215] [MGI Ref ID J:103618]
Zhou C; Wawrowsky K; Bannykh S; Gutman S; Melmed S. 2009. E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. Mol Endocrinol 23(12):2000-12. [PubMed: 19837943] [MGI Ref ID J:154681]
Zhou Z; Flesken-Nikitin A; Levine CG; Shmidt EN; Eng JP; Nikitina EY; Spencer DM; Nikitin AY. 2005. Suppression of melanotroph carcinogenesis leads to accelerated progression of pituitary anterior lobe tumors and medullary thyroid carcinomas in Rb+/- mice. Cancer Res 65(3):787-96. [PubMed: 15705875] [MGI Ref ID J:96382]
Ziebold U; Lee EY; Bronson RT; Lees JA. 2003. E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Mol Cell Biol 23(18):6542-52. [PubMed: 12944480] [MGI Ref ID J:85441]
Ziebold U; Reza T; Caron A; Lees JA. 2001. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev 15(4):386-91. [PubMed: 11230146] [MGI Ref ID J:67783]
Zoumpoulidou G; Broceno C; Li H; Bird D; Thomas G; Mittnacht S. 2012. Role of the tripartite motif protein 27 in cancer development. J Natl Cancer Inst 104(12):941-52. [PubMed: 22556269] [MGI Ref ID J:189317]
Animal Health ReportsProduction of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Colony Maintenance
Breeding & Husbandry Due to the fact that homozygotes die in utero, this Rb1tm1Tyj colony must be maintained by mating heterozygous mice to normal wildtype siblings. Heterozygotes may be intercrossed to produce homozygous embryos. Expected coat color from breeding:White Bellied Agouti
|Pricing for USA, Canada and Mexico shipping destinations
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3435.00
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
|Pricing for International shipping destinations
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $4465.50
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
|Wild-type from the colony
|002448 129S1/SvImJ
|Considerations for Choosing Controls
|Control Pricing Information for Genetically Engineered Mutant Strains.
For Licensing and Use Restrictions view the link(s) below:
- Notice to customers in Canada.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON's MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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A classic favorite to keep your name or message around long after the goodies are gone.
Imprinting Information:
Spot Color Imprint: Set-up charge per color $50 per color. 2nd color running charge $.60. For individual mailers add $1.00. Re-order set-up charge $25 per color, 2nd color running charge $.60.
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My Tot Travels
Lilliana is a wife, mother, employee and entrepreneur trying to balance responsibilities with fun while raising her first child. A former PR pro and current Marketing Director for a group of doctors, Lilli and her husband loved travel, and when they had their daughter realized what a production it could be to take a trip with a baby (or any kids for that matter).
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Modesto Nuts at San Jose Giants
Tue, Apr 23, 2013 7:00 pm
San Jose Municipal Stadium, San Jose, CA
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McFarland and Whitman Named Hilbert Student Athletes Of November
- Release Date:
- December 7, 2012
- Contact:
- The Office of Sports Information
- (716) 649-7900 ext. 333
MBB November Stats WBB Novmeber Stats
Dan McFarland {in photo to left} and Natalie Whitman {in photo to right} have been named as the Hilbert College Student-Athletes of the Month for November, 2012. Both basketball athletes, last season's team MVPs, began their 2012-13 season where they left off last winter.
McFarland helped lead the Hawks to a 5-1 overall record in November. The 6'2" senior guard averaged 16.5 points, 4 assists and 6.2 rebounds per game. His 31 minutes a game were very productive for Hilbert, for when he wasn't attacking the hoop for a score he was looking for an open teammate to dish the ball to. McFarland was 37 of 69 from the floor (.536) and was 20 of 25 from the foul line (.80). The lefty led Hilbert with 19 points in the team's 40-point AMCC victory over D'Youville College. His most impressive game was against Keuka when he led the Hawks in scoring/rebounding/assists (19/8/8) in their road win November 26th. McFarland was named to the Hilbert Tip Off All-Classic team.
McFarland (Lancaster, NY/St. Mary's) is a criminal justice major and carries a 3.2 cumulative GPA.
The 5'11" Whitman also led her team in minutes played (32) as well as 15.7 points and 9.0 rebounds per game. She was credited with 54 rebounds and her 26 offensive boards were more rebounds than all (but one) teammate earned for the month. Her .390 field goal percentage (32 of 82) was second best for the Hawks and she earned 42 attempts at the foul line, making 30 (.714). Whitman produced two double-doubles in November with her most impressive game being the home win over Cazenovia when she hit for 21 points and 21 rebounds. She also scored 25 points and pulled down 10 rebounds in the Hawks lop-sided road win over Penn State Du Bois November 17th.
Whitman (Lockport, NY/Starpoint) is a forensic science/crime scene investigation major with a 4.0 GPA after her first semester at Hilbert last spring.
Hilbert College, located in suburban Hamburg, N.Y., south of Buffalo, is a private four-year college founded in 1957 in the Catholic Franciscan tradition. With nearly 1,100 students, Hilbert is a dynamic Western New York college that offers career-focused majors, including one of the top criminal justice programs in the region, and more than 50 minors and concentrations. The college's engaging, student-centered campus community offers numerous leadership, internship, and service learning opportunities from which students launch successful careers while making positive changes in their communities. The Hilbert Blueprint promotes a well-rounded student experience over four years – starting with the Foundations Seminar in the freshman year, followed by Sophomore Service, Junior Symposium, and culminating with the Senior Capstone. Hilbert has expanded its academic offerings with the college's first graduate programs and new Accelerated Degree Programs geared to adult learners.
Upcoming Events
- First Year Student Orientation
- Aug 14, 2015
- Summer Session A2 Ends
- Aug 21, 2015
- First Year Student Orientation
- Aug 28, 2015


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Alfresco Day Rome
Majority of this event will be in Italian.
Every day, leading companies and governments in 80 countries around the world are using Alfresco to streamline document-intensive business processes and enable secure collaboration - behind the firewall, in the cloud and even on their mobile devices. And they are doing it with our open source enterprise content management solutions at 1/2 the cost and in 1/2 the time of legacy, proprietary ECM vendors.
Come and sign up today and hear how Alfresco can help you manage your content and processes efficiently, securely and comfortably.
John Powell, Founder of Alfresco will share his vision of the Enterprise Content Management future. Don't miss out on this great opportunity to speak to Alfresco's founder and partner network.
Agenda dell'evento:
09:30 - 10:00 Registrazione Silvia Speranza & Marketing Team
10:00 - 10:15 Benvenuto Alberto Fidanza, Sales Director – Southern Europe
10:15 - 10:45 Alfresco's Vision: Why is Alfresco the right ECM solution for your organisation? John Powell, Founder of Alfresco
10:45 - 11:30 Alfresco One – la soluzione ECM ibrida per la collaborazione sicura Maurizio Pillitu, EMEA Technical Consultant & Costantino Croce, Solution Consultant
11:30 - 11:45 Coffee Break
11:45 - 12:30 Alfresco Workdesk: Manage cases and contracts, fast and efficiently (including Demo) Dr. Rainer Pausch, Director Of Product Marketing & Costantino Croce, Solution Consultant
12:30 - 13:00 Presentazione di progetti implementati presso clienti Alfresco ING. Carlo Cammelli, Technology Sector Chief, Consiglio Regione Toscana
13:00 - 13:15 Alfresco Italia, la proposta commerciale Stefano D'Orazio, Country Sales Manager, Italy
13:15 - 13:30 Chiusura dei lavori John Powell, Founder of Alfresco
13:30 - 14:30 Pranzo


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Ace singer Sonu Nigam's mother Shobha Nigam passed away today. She was suffering from illness for a long time and today she breathed her last. She was on medication for a year. Sonu's good friend and fellow singer Kailash Kher tweeted, "sonu nigam bhaiya's mother is no more, God pls keep h...read more
Salim Merchant Follow


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West Texas may be associated with wind and cactus but for cave divers, one of the most sought after sites in the country can be found in the middle of the Big Bend.
"It's not a place you expect to see cave dives much less deep cave dives occurring," said Dr. Tom Iliffe, a professor at Texas A&M Galveston and one of the world's leading cave biologists.
"We're very fortunate to be able to have the privileges to be able to go into this site," said Iliffe.
Last month, he lead a team of scientists to Phantom Springs Cave near Balmorhea, Texas. The sight is owned by the The Bureau of Reclamation and each year the bureau only issues two permits to dive into the environmentally sensitive cave.
"It's a special kind of people who do these very deep dives and it's very, very different from normal recreational scuba diving. Nothing like it at all," said Iliffe.
Their mission is to explore strange new worlds, to seek out new life, and to boldly go where no one has gone before. Sounds like space, doesn't it.
"It's something that is indescribable. To be in a place that no human has ever been before, to see an animal no one even suspected existed," said Iliffe.
The first mile of the dive is considered shallow with depths of only 20 to 30 feet but the next 2,000 feet of the cave plummets into the Earth.
"We found that it immediately started dropping down deeper, deeper, and deeper. In stair step fashion."
After reaching a depth of 460 feet, the team had to turn around. Despite having state of the art diving technology, this was as far as they could possibly go.
"Shining our lights down the tunnel, there is no end in sight. It's something that leaves plenty of room for future exploration but we need new diving technology to go that deep and that far into an underwater cave system," said Iliffe.
Despite the journey into the depths only taking an hour, getting out of the cave takes another seven due to currents and decompression.
Iliffe does this with the hopes of finding new discoveries like others he has found in caves around the world. His discoveries have even been featured in National Geographic Magazine.
"Types of organisms that previously had been unknown from the planet and we're coming across. It's like going back and finding a dinosaur almost," said Iliffe.
It's all in the name of science and for Iliffe who definitely has to catch your breath after seeing such incredible sights.
"It's just a transcendental experience to go into these caves," said Iliffe.
Dr. Iliffe and his team will go over their findings of the Phantom Springs Cave over the next year and plan to return to the cave in the summer of 2014 to explore even deeper into its abyss.
If you want to find out more about the expedition or see more video and pictures, we've got links to the expeditions website below.
Video Courtesy of: Becky Kagan Schott with Liquid Productions, LLC. There is a link with more video from Liquid Productions, LLC below.
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Sherry Shaffner, who has been the driving force in the growth of the Carroll County Chamber of Commerce for the past two and a half years, will step as executive director of the organization on Oct. 9.
Shaffner called her decision to accept a position with the Alleghany Partnership for Children in Sparta, NC, "the hardest decision I've ever had to make. I love this job, I love working with the public. Hillsville has been great and very supportive, and given me the opportunity to grow as a person with them. (Oct. 9) will be a sad day, but an exciting one."
When Shaffner took the executive director position with the chamber in March of 2010, she admitted there wasn't much of an organization. There are now 86 members.
"The membership was very low and there was no board of directors, so I handled all the operations on my own," says Shaffner. "I feel I've accomplished a lot. I added some new, successful fund-raising events, such as the Miss Carroll County Chamber of Commerce Pageant, we participate in Safe Halloween, and I brought back the annual banquet, which is when our board of directors is elected."
One reason behind Shaffner's decision to resign is the fact that the executive director position is just part-time.
"Although we've had some success, the chamber needs to grow in order to afford a full-time executive director," says Shaffner. "I hope whoever they hire will see the accomplishments that we've made, and strive to grow even more. There are great people in this chamber and in Hillsville. The local businessmen have some good ideas and opportunities, if they just work together."
Shaffner will be in charge of the daily operations at Alleghany Partnership for Children, which also sponsors various fund-raising events.
"I guess my experience here with the chamber will come in handy," adds Shaffner.


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The next logical step is, naturally, bacon textiles. So get ready for an all body lube job. After all, cholesterol is fat, and fat is slippery. Lets lube those (heart) valves :)
Step 1: Ingredients and Tools
1 Package of sliced Bacon (at least 12 slices) -- any bacon will do, even blasphemous turkey bacon.
1 Baking Sheet
Paper towels
Hunger for Bacon
Step 2: Foil and Grease
Step 3: Weaving
Weave using an over/under pattern making a 6X6 matrix. Make it as tight as possible with minimal overlap. If your bacon strips have a wider side -- flip between wide and thin as you weave. This ensures your mat is not lopsided. Remember that bacon shrinks when cooked; this pulls the weave even tighter strengthening the structure.
Step 4: Bake
As for me I love Bacon!
how would you season the bacon?
very unique way of using bacon.
I should just have this entire section of the thread deleted - and really, attacking one's grammar for personal gain is always a lose-lose situation. This is especially so when the attack itself is grammatically incorrect...
Also, it was most certainly not "for personal gain". What do I have to gain? A stranger insulted me. My original post is neither "dumb" nor made up, as Punkguyta suggests.
Did you start with "Irony..." to indicate the irony of you getting involved in this back-and-forth just to say you are above such things?
as im mexican i will also include some "cecina enchilada"
If turkey bacon is blasphemy, is a turducken the antichrist of bacon?


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Images from the illinois drill team association state championships saturday in champaign.
updated: 3/17/2013 12:25 AM
Images: IDTA state finals
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Rodney Yee's AM/PM Yoga For Beginners DVD
Strengthen, balance, and revitalize your mind and body
Join Rodney Yee and Colleen Saidman as they take you on a journey to better health and well-being each and every day. Includes two complete workouts, one for the morning and one for the evening plus a bonus downloadable meditation. Enliven and energize your body in the morning and release tension in the evening. Total run time: 50 minutes.
Click to view Rodney Yee's entire DVD collection or Colleen Saidman's entire DVD collection.
Rodney Yee's AM/PM Yoga for Beginners DVD Features:
- Revitalizing morning and evening workouts designed for yoga beginners
- Teaches you how to relax and be in control of your mind
- Releases tension and energizes your body
- Made exclusively by Gaiam
Also available digitally.
Total run time: 50 minutes
A.M. Energize (25 minutes): Wake up to the gentle waves of the ocean while centering, enlivening, and balancing your mind and body
P.M. Unwind (25 minutes): Leave the worries of the day behind and release tension as you move through a series of restorative yoga poses
BONUS downloadable A.M. and P.M. meditations (12 minutes): Soothe your mind and feel at peace when you wake up and after a busy day
Get to Know Rodney YeeRodney Yee was a professional ballet dancer who later studied Iyengar yoga. He travels nationally and internationally to teach workshops, teacher-training and retreats. Rodney has been designing and performing in Gaiam programs for over 10 years. He has been featured on Oprah and other national programs.
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GAIAMTV~ Another suggestion is to sign up for GaiamTV at www.gaiamtv.com - For a small fee after the free trial period, you will have access to hundres of yoga videos for all skill levels plus a whole lot more. We are sure you will find your next favorite yoga routine there. Feel free to contact our customer support team at firstname.lastname@example.com or 1-800-482-3747 if you need help selecting a new DVD or signing up for GaiamTV. We are happy to help.


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Warhammer Fantasy Roleplay
For every age, there are heroes willing to stand up and fight, or common folk for whom destiny has its own unseen plans. This age sees the arrival of many new warriors. Dwarfs, humans, high elves, and the enigmatic wood elves must set aside their differences to face the forces bent on destroying the Old World. Fortune favors the brave, and these heroes will need all the fortune they can muster.
Warhammer Fantasy Roleplay is a new, exciting way to experience the popular Warhammer Fantasy setting. It is a grim world, constantly at war. As a hero, you will take up weapon, spell, or prayer and do your best to combat the might of enemies terrifying to behold. As the game master, you will make the lands of the Old World real as you craft the story, the people, creatures, and the mysteries the other players will encounter during their adventures.
Rolling a Story
Using a new task resolution system featuring custom dice, Warhammer Fantasy Roleplay gives you unparalleled story-telling options. Every roll of the dice has a story to tell, providing far more information and flavour than just "you hit" or "you miss." These dice represent the abilities and skills your characters will gain, as well as include the whims of fate. With each roll, players will be able to see how the check succeeded or failed. Did they make it through based on their natural skills or did they just get lucky as fortune intervened?
How Much Risk?
With every decision comes a risk to assess. In Warhammer Fantasy Roleplay, heroes will decide how they wish to approach any situation. Do they rush in, swords drawn, in an attempt to quickly overwhelm their foes? Do they advance cautiously and appraise the situation before entering to gain advantage? Your stance, reckless or conservative, will guide your actions and the bonuses they provide. As stances can be changed on the fly, players will have new levels of control over situations.
Action at Hand
Mighty warriors perform mighty deeds. You can quickly reference the full-colour action cards to see what your abilities and innate skills can accomplish, allowing players to spend more time focusing on the task at hand. From spells, blessings, and attacks to social gambits, and reactions, and acrobatics you will have the actions you need to tell your character's tale.
More Fun in a Group
Every hero is powerful on their own, but when combined, heroes interact in interesting, new ways. Each party will be able to select a party sheet, which helps track and manage the group as a whole. Will the dwarf and high elf be able to put aside their differences in order to work as a cohesive unit, or will the ancient grudges be too much for them? Can the human overcome the arrogance of the high elf, and can the high elf overcome the brashness of the short-lived human? Each party sheet also provides special abilities for the party members. In this way, every group becomes far more than the sum of its parts.
Plentiful Careers
Straight from the world of Warhammer, there are a constantly growing number of careers for heroes to choose from. Every career provides valuable skills and abilities that will give adventurers a definitive advantage in their exploits. From the resolve of the Witch Hunter and the deadliness of the Dwarf Troll Slayer to the keen eyes of the Wood Elf Waywatcher, or the fiery magic of a Bright Wizard, there are many exciting paths to follow.
How Do I Start?
A wide range of options are available for players and game masters interested in getting into Warhammer Fantasy Roleplay.
The Warhammer Fantasy Roleplay Core Set is the single most comprehensive entry point for new players and GMs alike. It contains rules and components to support an entire gaming group.
Inside this large sturdy box you will find four full-colour books, along with all the cards, tokens, and other components you'll need, including a set of thirty custom dice. The main rulebook introduces all the mechanics and key information you need to get started. Also included are three tomes to provide you with more information on the world, and give you new opportunities for character creation.
The Tome of Mysteries is your guide to wizards and the winds of magic. Follow along with grey wizard Gavius Klugge as he gives you insight into this powerful career path. The Tome of Blessings provides information on priests and the gods they follow. Information on the Cults of Sigmar, Shallya, Ulric, Taal, and others are contained within this volume. The Tome of Adventure is a book for the game master, and provides valuable information on running sessions, background and statistics on a variety of enemies, information on how to get the most out of your roleplaying experience, and a complete introductory adventure.
The Core Set is best suited for a group of four players – one Game Master and three Player Characters. Want to add more players to your group? Are you looking for certain content, without purchasing an entire Core Set? Our Guides and Vaults are the answer. For more on Guides and Vaults, you can also view a recent seminar by Jay Little (Total Running Time: 41:39 - Quicktime 239.7 MB). Skip ahead to 12:00, when Jay discusses these products in detail.
These two products are perfect for players wanting their own rulebook and their own set of WFRP's revolutionary components. The Player's Guide is a hardcover rulebook with over 300 pages of player information. With handy charts and tables covering all the player components from the Core Set, it is even possible for players to experience WFRP with as many or few components as they wish.
The Player's Vault is packed full of player components, making it a great place to start for players wanting to jump into a campaign with their own materials. These tokens, cards, and sheets come packaged in a sturdy box that serves as a great way to store your character between sessions.
The Game Master's Guide is an exceptional tome for the aspiring game master. Armed with the rules and information found within this hardcover book, you will be ready to craft memorable stories and perilous encounters for your players. With charts and tables compiling all the information from wound decks, miscast decks, and conditions, as well as rules for corruption and mutation (introduced in the Winds of Magic expansion) and disease (from Signs of Faith), this guide will also come in handy for veteran GMs as well.
As for the GM's components, the Game Master's Vault complements all the information from the Game Master's Guide by presenting it on cards, sheets, and tokens. Also packaged in a sturdy box with a set of 12 custom WFRP dice, the Game Master's Vault is useful for new GMs as well as those who would like to expand their pool of WFRP components.
The Creature Guide is a hardcover book that features rules, stats, and flavour for over a hundred creatures and adversaries. This book is ideal for game masters looking to build memorable encounters for their campaigns, as well as players looking to study their potential foes.
The Creature Vault presents the information and rules from The Creature Guide in component form. Creature Group Sheets and Creature Cards make building encounters a breeze, and new creature Action Cards offer a whole new level of customisation. Packaged in a sturdy box which can be used to store your planned encounters, the Creature Vault is a great way to organise and run your encounters.
What Is a Roleplaying Game?
In a Roleplaying Game (RPG) you create an alter ego, a fictional character like one of the heroes you've read about or seen in films. Using the game rules, you and your friends create characters and develop them as you play through a series of adventures. Imagine a group of detectives working together to solve a case or a company of knights sent to defeat a monster. Rather than read or watch a story, you tell it.
How is the story told? How do you decide what happens? What do you do if you and your friend disagree? That's where rules come in. Roleplaying is only half of the story; the other half is the game itself. Warhammer Fantasy Roleplay presents you with the rules of the game – how to design your character, how to resolve actions and how to have fun doing so. During a game of Warhammer Fantasy Roleplay, the players roll pools of custom dice to determine the outcome of combat, social intrigues, magic, or other risky actions. The custom dice add a game playing element to the RPG and help prevent the outcome of actions from becoming too predictable. The full-colour play aids and reference material makes it easy to keep track of special abilities, actions, and other important information.
Before you start playing, you and your friends will need to decide which of you will be the game master (GM). The GM is the referee and the lead storyteller, the person who describes the game to the other players. The GM presents the stories and situations, provides the setting and its denizens, and adjudicates the rules. The other players take on the roles of the characters, around which the action primarily revolves. These characters are known as the Player Characters (PCs). They describe their intentions and actions to the GM, who then decides how their actions affect the plot.
How Do You Win?
The answer is up to you. The game master is not set against the heroes. Both the game master and the hero party are working together to create a memorable experience for all involved. Each session gives both parties a chance to become part of something larger, and allow them to create their own legend.
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Warhammer Fantasy Roleplay collection is © Games Workshop Limited 1986, 2005. This edition © Games Workshop Limited 2013. Warhammer, Warhammer Fantasy Roleplay, the foregoing marks' respective logos and all associated marks, logos, places, names, creatures, races and race insignia/devices/logos/symbols, vehicles, locations, weapons, units and unit insignia, characters, products and illustrations from the Warhammer World and Warhammer Fantasy Roleplay game setting are either ®, ™ and/or © Games Workshop Ltd 1986-2013, variably registered in the UK and other countries around the world. This edition published under license to Fantasy Flight Publishing, Inc. All Rights Reserved to their respective owners.


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Tuesday, May 7, 2013
Those Summerville "Ladies in Red" are at it again, doing what they do best…spotlighting, celebrating, educating, donating and lending a helping hand. This time they even took time out to give themselves a pat on the back. During a week highlighted by the presentation of an oversized check to Dorchester Children's Center, members of the Summerville Alumnae Chapter of Delta Sigma Theta Sorority, Incorporated (a.k.a. "The Ladies in Red") observed the chapter's twenty-fifth anniversary. The celebration saluted Summerville Alumnae's charter members and focused on the chapter's rich legacy of public service in the Dorchester County Community.
Delta Sigma Theta Sorority, Inc. is a private, non-profit organization whose purpose is to provide assistance and support through established programs in local communities throughout the world. A sisterhood of more than 300,000 predominantly Black college-educated women, the Sorority currently has over 900 chapters located in the United States, England, Japan (Tokyo and Okinawa), Germany, the Virgin Islands, Bermuda, the Bahamas and the Republic of Korea. The Sorority was founded on January 13, 1913 by twenty-two collegiate women at Howard University. These students wanted to use their collective strength to promote academic excellence and to provide assistance to persons in need. The first public act performed by the Delta Founders involved their participation in the Women's Suffrage March in Washington, D.C., during March of 1913. Delta Sigma Theta was incorporated in 1930.
Summerville Alumnae, the 784th chapter of Delta Sigma Theta Sorority, Inc., was chartered on April 24, 1988. Twenty Dorchester County Deltas (Johnnie G. Mazyck, Ethel L.F. Harrison, Nancy Smith Doughty, Grace Wyatt Reese, Linda Pendergraft-Quash, Linda J. Patton, Valildra Dessasure Berry, Ruth S. Bowman, Zeddie D. Boyd, Flossie G. Grundy, Juanita J. Hill, Shirley L. Jacobs, Harmoniest Simmons Busby, Mary A. Stevens, Irma G. Street, Terri T. Terry, Doris Porcha Porter Warren, Vashti Killingbeck Washington, LaVerne Williams and Cheryl Young) were present to sign the charter and thereafter became indelibly linked to the chapter's history as the Charter Members of the Summerville Alumnae Chapter of Delta Sigma Theta Sorority, Incorporated. From these focused and determined visionaries, Summerville Alumnae has grown into a sisterhood of approximately 140 professional women from throughout the tri-county area. This "Sisterhood Called to Serve", as their work will attest, has consistently worked to impact the local community in a positive manner. Individuals and organizations have been the recipients of the chapter's generosity. Since 1988, Summerville Alumnae has awarded over $90,000 in scholarships to local high school students, conducted college and career workshops, presented political and social action forums, mentored young men and women from throughout Dorchester County, donated meals for the homeless and organized benefit fundraisers for other charitable organizations.
The chapter kicked off the Silver Anniversary Chartering Celebration on Saturday, April 20th when chapter members visited residents at four nursing homes in upper and lower Dorchester County. Each center was presented with centerpieces for the dining room tables, a CD of 50's and 60's music and movie DVDs from the same eras. On April 22nd, chapter retirees participated in the School America Project, reading to young students at Beech Hill, Windsor Hill, Harleyville, and Williams Memorial Elementary Schools. In honor of one of the chapter's first service projects, School America bookmarks were presented on April 23rd to middle school students at Alston, Dubose, Gregg, Harleyville-Ridgeville, and St. George Middle schools. During the evening of April 24th, chapter members recognized their own. Eleven of the 18 surviving chartering sorors were honored with gifts, testimonials and an evening of festive fellowship at First Missionary Baptist Church. But the chapter's real celebration was yet to come.
Very quietly during the month of March, chapter members participated in a fundraising event. The first ever "Summerville Alumnae Delta Benefit Walk" was designed to support a Dorchester County non-profit. On April 27, 2013, the Summerville Alumnae Chapter of Delta Sigma Theta Sorority, Inc., a sisterhood of college-educated women committed to public service, marked their first twenty-five years of service by presenting $5,000 to Mr. Bob Ingram, Fund Development Director for the Dorchester Children's Center. As remarked by the chapter's first President, Mrs. Johnnie Good Mazyck, "My, how we've grown!"
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BIRMINGHAM, Ala.---The Chattanooga Mocs (4-8) competed for 40 minutes against a hot UAB (9-2) squad losing 67-52 in Bartow Arena Wednesday night. The undermanned Mocs playing without leading scorer Z. Mason (Nashville, Tenn.) kept it close for a majority of both halves before succumbing to one of Conference USA's favorites.
"We played one of our better games tonight," Head Coach Will Wade noted. "I was proud of our guys because we competed for 40 minutes for the first time in a while. We competed hard and played well.
"It is certainly something we can build on," he continued. "UAB is a tremendous team with unbelievable athletes. Our guys competed and that's all we can ask."
It was a nip-and-tuck affair early. Eric Robertson (Huntsville, Ala.) kept the pendulum swinging with a three-pointer at 9:21 for a 19-17 Mocs lead. Jordan Swing immediately answered for the Blazers with a three of his own to put his team back up 20-19.
Chattanooga scored six points on back-to-back possessions. Lance Stokes (Orlando, Fla.) turned in the traditional three-point play with a power post move drawing a foul from Fahro Alihodzic. Greg Pryor (Memphis, Tenn.) drained a trey 34 seconds later putting the Mocs up 25-20 with 7:48 remaining in the opening frame.
It was all UAB from there. Chad Frazier's layup at 4:57 was the eighth, and final, lead change of the game. The Blazers ended the first half on a 15-2 run for a 35-27 halftime lead.
UAB got off to a fast start after the break. Its lead swelled to 13, 46-36, on two Alihodzic free tosses at 13:39. The Mocs would not break.
Back-to-back baskets by Robertson jump-started an 11-2 run. Consecutive threes from Alex Bran (Memphis, Tenn.) capped it to cut the margin to four, 48-44, with 11:14 remaining. But it was as close as it would get.
It was a nine-point game with 3:24 to go after a Gee McGhee (Baton Rouge, La.) free throw. The Blazers scored nine unanswered points before Martynas Bareika (Kedainiai, Lithuania) drained a trey for the final score of 67-52.
Chattanooga opened the game making four of its first eight three-point attempts. It went four of 22 from beyond the arc the rest of the way.
"We got squared to the basket better," Wade added. "We had some wide-open three's, but we have to be able to stick them.
"We had some good looks where we could have built our lead and stopped some runs, but we have to keep working on our shooting and get better there."
UAB was dominant on the glass. It out-boarded the Mocs 46-30. It had a 32-13 advantage on points in the paint utilizing a decided size advantage.
The Mocs head home for the holidays. They return to the Scenic City December 29-30 for the Dr Pepper Classic taking on Grand Canyon on day one. Maine and Middle Tennessee open the event. Game times are 4:30 and 7 p.m. (ET) each day.
Chattanooga can be listened to live on ESPN 105.1 FM the Zone in Chattanooga, or go to the men's basketball schedule page on GoMocs.com for links to video (ppv), audio (free) and live stats. You can follow @GoMocsMBB on twitter for live updates as well.
GoMocs.com is the official website of the Chattanooga Mocs. The Mocs can also be followed on their official Facebook page or on Twitter. Find out how to join the UTC Mocs Club and support more than 300 student-athletes by clicking here.