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- Primary skin fibroblasts as a model of Parkinson's disease (2012)
- Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease. Different animal models and cell models like patient skin fibroblasts and recombinant cell lines can be used as model systems for Parkinson's disease. Skin fibroblasts present a system with defined mutations and the cumulative cellular damage of the patients. PINK1 and Parkin genes show relevant expression levels in human fibroblasts and since both genes participate in stress response pathways, we believe fibroblasts advantageous in order to assess, e.g. the effect of stressors. Furthermore, since a bioenergetic deficit underlies early stage Parkinson's disease, while atrophy underlies later stages, the use of primary cells seems preferable over the use of tumor cell lines. The new option to use fibroblast-derived induced pluripotent stem cells redifferentiated into dopaminergic neurons is an additional benefit. However, the use of fibroblast has also some drawbacks. We have investigated PARK6 fibroblasts and they mirror closely the respiratory alterations, the expression profiles, the mitochondrial dynamics pathology and the vulnerability to proteasomal stress that has been documented in other model systems. Fibroblasts from patients with PARK2, PARK6, idiopathic Parkinson's disease, Alzheimer's disease, and spinocerebellar ataxia type 2 demonstrated a distinct and unique mRNA expression pattern of key genes in neurodegeneration. Thus, primary skin fibroblasts are a useful Parkinson's disease model, able to serve as a complement to animal mutants, transformed cell lines and patient tissues.
- ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice (2012)
- Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)31. This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing, resulting in degenerative processes affecting preferentially cerebellar neurons. As a faithful animal model, we generated a knock-in mouse replacing the single CAG of murine Atxn2 with CAG42, a frequent patient genotype. This expansion size was inherited stably. The mice showed phenotypes with reduced weight and later motor incoordination. Although brain Atxn2 mRNA became elevated, soluble ATXN2 protein levels diminished over time, which might explain partial loss-of-function effects. Deficits in soluble ATXN2 protein correlated with the appearance of insoluble ATXN2, a progressive feature in cerebellum possibly reflecting toxic gains-of-function. Since in vitro ATXN2 overexpression was known to reduce levels of its protein interactor PABPC1, we studied expansion effects on PABPC1. In cortex, PABPC1 transcript and soluble and insoluble protein levels were increased. In the more vulnerable cerebellum, the progressive insolubility of PABPC1 was accompanied by decreased soluble protein levels, with PABPC1 mRNA showing no compensatory increase. The sequestration of PABPC1 into insolubility by ATXN2 function gains was validated in human cell culture. To understand consequences on mRNA processing, transcriptome profiles at medium and old age in three different tissues were studied and demonstrated a selective induction of Fbxw8 in the old cerebellum. Fbxw8 is encoded next to the Atxn2 locus and was shown in vitro to decrease the level of expanded insoluble ATXN2 protein. In conclusion, our data support the concept that expanded ATXN2 undergoes progressive insolubility and affects PABPC1 by a toxic gain-of-function mechanism with tissuespecific effects, which may be partially alleviated by the induction of FBXW8.
- Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration (2009)
- Background Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD. Methodology/Principal Findings Now we generated a PINK1 deficient mouse and observed several novel phenotypes: A progressive reduction of weight and of locomotor activity selectively for spontaneous movements occurred at old age. As in PD, abnormal dopamine levels in the aged nigrostriatal projection accompanied the reduced movements. Possibly in line with the PARK6 syndrome but in contrast to sporadic PD, a reduced lifespan, dysfunction of brainstem and sympathetic nerves, visible aggregates of alpha-synuclein within Lewy bodies or nigrostriatal neurodegeneration were not present in aged PINK1-deficient mice. However, we demonstrate PINK1 mutant mice to exhibit a progressive reduction in mitochondrial preprotein import correlating with defects of core mitochondrial functions like ATP-generation and respiration. In contrast to the strong effect of PINK1 on mitochondrial dynamics in Drosophila melanogaster and in spite of reduced expression of fission factor Mtp18, we show reduced fission and increased aggregation of mitochondria only under stress in PINK1-deficient mouse neurons. Conclusion Thus, aging Pink1 -/- mice show increasing mitochondrial dysfunction resulting in impaired neural activity similar to PD, in absence of overt neuronal death.
- The mitochondrial kinase PINK1, stress response and Parkinson's disease (2009)
- Mitochondrial dysfunction is well documented in presymptomatic brain tissue with Parkinson's disease (PD). Identification of the autosomal recessive variant PARK6 caused by loss-of-function mutations in the mitochondrial kinase PINK1 provides an opportunity to dissect pathogenesis. Although PARK6 shows clinical differences to PD, the induction of alpha-synuclein "Lewy" pathology by PINK1-deficiency proves that mitochondrial pathomechanisms are relevant for old-age PD. Mitochondrial dysfunction is induced by PINK1 deficiency even in peripheral tissues unaffected by disease, consistent with the ubiquitous expression of PINK1. It remains unclear whether this dysfunction is due to PINK1-mediated phosphorylation of proteins inside or outside mitochondria. Although PINK1 deficiency affects the mitochondrial fission/fusion balance, cell stress is required in mammals to alter mitochondrial dynamics and provoke apoptosis. Clearance of damaged mitochondria depends on pathways including PINK1 and Parkin and is critical for postmitotic neurons with high energy demand and cumulative stress, providing a mechanistic concept for the tissue specificity of disease.
- Restriction of trophic factors and nutrients induces PARKIN expression (2011)
- Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder and manifests at old age. While many details of its pathogenesis remain to be elucidated, in particular the protein and mitochondrial quality control during stress responses have been implicated in monogenic PD variants. Especially the mitochondrial kinase PINK1 and the ubiquitin ligase PARKIN are known to cooperate in autophagy after mitochondrial damage. As autophagy is also induced by loss of trophic signaling and PINK1 gene expression is modulated after deprivation of cytokines, we analyzed to what extent trophic signals and starvation stress regulate PINK1 and PARKIN expression. Time course experiments with serum deprivation and nutrient starvation of human SH-SY5Y neuroblastoma cells and primary mouse neurons demonstrated phasic induction of PINK1 transcript up to twofold and PARKIN transcript levels up to sixfold. The corresponding threefold starvation induction of PARKIN protein was limited by its translocation to lysosomes. Analysis of primary mouse cells from PINK1-knockout mice indicated that PARKIN induction and lysosomal translocation occurred independent of PINK1. Suppression of the PI3K-Akt-mTOR signaling by pharmacological agents modulated PARKIN expression accordingly. In conclusion, this expression survey demonstrates that PARKIN and PINK1 are coregulated during starvation and suggest a role of both PD genes in response to trophic signals and starvation stress.
- A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice (2010)
- BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically by the preferential vulnerability of the dopaminergic nigrostriatal projection neurons. METHODOLOGY/PRINCIPAL FINDINGS: Here, we used two mouse lines overexpressing human A53T-SNCA and studied striatal dysfunction in the absence of neurodegeneration to understand early disease mechanisms. To characterize the progression, we employed young adult as well as old mice. Analysis of striatal neurotransmitter content demonstrated that dopamine (DA) levels correlated directly with the level of expression of SNCA, an observation also made in SNCA-deficient (knockout, KO) mice. However, the elevated DA levels in the striatum of old A53T-SNCA overexpressing mice may not be transmitted appropriately, in view of three observations. First, a transcriptional downregulation of the extraneural DA degradation enzyme catechol-ortho-methytransferase (COMT) was found. Second, an upregulation of DA receptors was detected by immunoblots and autoradiography. Third, extensive transcriptome studies via microarrays and quantitative real-time RT-PCR (qPCR) of altered transcript levels of the DA-inducible genes Atf2, Cb1, Freq, Homer1 and Pde7b indicated a progressive and genotype-dependent reduction in the postsynaptic DA response. As a functional consequence, long term depression (LTD) was absent in corticostriatal slices from old transgenic mice. CONCLUSIONS/SIGNIFICANCE: Taken together, the dysfunctional neurotransmission and impaired synaptic plasticity seen in the A53T-SNCA overexpressing mice reflect early changes within the basal ganglia prior to frank neurodegeneration. As a model of preclinical stages of PD, such insights may help to develop neuroprotective therapeutic approaches.
- A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP (2011)
- Parkinson's disease (PD) is a neurodegenerative disorder frequent at old age characterized by atrophy of the nigrostriatal projection. Overexpression and A53T-mutation of the presynaptic, vesicle-associated chaperone alpha-synuclein are known to cause early-onset autosomal dominant PD. We previously generated mice with transgenic overexpression of human A53T-alpha-synuclein (A53T-SNCA) in dopaminergic substantia nigra neurons as a model of early PD. To elucidate the early and late effects of A53T-alpha-synuclein on the proteome of dopaminergic nerve terminals in the striatum, we now investigated expression profiles of young and old mice using two-dimensional fluorescence difference in gel electrophoresis (2D-DIGE) and mass spectrometry. In total, 15 proteins were upregulated and 2 downregulated. Mice before the onset of motor anomalies showed an upregulation of the spot containing 14-3-3 proteins, in particular the epsilon isoform, as well as altered levels of chaperones, vesicle trafficking and bioenergetics proteins. In old mice, the persistent upregulation of 14-3-3 proteins was aggravated by an increase of glial fibrillary acidic protein (GFAP) suggesting astrogliosis due to initial neurodegeneration. Independent immunoblots corroborated GFAP upregulation and 14-3-3 upregulation for the epsilon isoform, and also detected significant eta and gamma changes. Only for 14-3-3 epsilon a corresponding mRNA increase was observed in midbrain, suggesting it is transcribed in dopaminergic perikarya and accumulates as protein in presynapses, together with A53T-SNCA. 14-3-3 proteins associate with alpha-synuclein in vitro and in pathognomonic Lewy bodies of PD brains. They act as chaperones in signaling, dopamine synthesis and stress response. Thus, their early dysregulation probably reflects a response to alpha-synuclein toxicity. Electronic supplementary material: The online version of this article (doi:10.1007/s00702-011-0717-3) contains supplementary material, which is available to authorized users.
- Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress (2010)
- The presynaptic protein alpha-synuclein has received much attention because its gain-of-function is associated with Parkinson's disease. However, its physiological function is still poorly understood. We studied brain regions of knock-out mice at different ages with regard to consistent upregulations of the transcriptome and focused on glyoxalase I (GLO1). The microarray data were confirmed in qPCR, immunoblot, enzyme activity, and behavior analyses. GLO1 induction is a known protective cellular response to glucose stress, representing efforts to decrease toxic levels of methylglyoxal (MG), glyoxal and advanced glycation endproducts (AGEs). Mass spectrometry quantification demonstrated a ubiquitous increase in MG and fructosyl-lysine as consequences of glucose toxicity, and consistent enhancement of certain AGEs. Thus, GLO1 induction in KO brain seems insufficient to prevent AGE formation. In conclusion, the data demonstrate GLO1 expression and glycation damage to be induced by alpha-synuclein ablation. We propose that wild-type alpha-synuclein modulates brain glucose metabolism.
- Loss of PINK1 impairs stress-induced autophagy and cell survival (2014)
- The mitochondrial kinase PINK1 and the ubiquitin ligase Parkin are participating in quality control after CCCP- or ROSinduced mitochondrial damage, and their dysfunction is associated with the development and progression of Parkinson's disease. Furthermore, PINK1 expression is also induced by starvation indicating an additional role for PINK1 in stress response. Therefore, the effects of PINK1 deficiency on the autophago-lysosomal pathway during stress were investigated. Under trophic deprivation SH-SY5Y cells with stable PINK1 knockdown showed downregulation of key autophagic genes, including Beclin, LC3 and LAMP-2. In good agreement, protein levels of LC3-II and LAMP-2 but not of LAMP-1 were reduced in different cell model systems with PINK1 knockdown or knockout after addition of different stressors. This downregulation of autophagic factors caused increased apoptosis, which could be rescued by overexpression of LC3 or PINK1. Taken together, the PINK1-mediated reduction of autophagic key factors during stress resulted in increased cell death, thus defining an additional pathway that could contribute to the progression of Parkinson's disease in patients with PINK1 mutations.
- Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice (2012)
- Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD. They display progressive motor deficits, abnormal cellular accumulation of α-syn, and deficits in dopamine-dependent corticostriatal plasticity, which, in the absence of overt nigrostriatal degeneration, suggest there are age-related deficits in striatal dopamine (DA) signalling. In addition A53Tα-syn overexpression in cultured rodent neurons has been reported to inhibit transmitter release. Therefore here we have characterized for the first time DA release in the striatum of mice overexpressing human A53Tα-syn, and explored whether A53Tα-syn overexpression causes deficits in the release of DA. We used fast-scan cyclic voltammetry to detect DA release at carbon-fibre microelectrodes in acute striatal slices from two different lines of A53Tα-syn-overexpressing mice, at up to 24 months. In A53Tα-syn overexpressors, mean DA release evoked by a single stimulus pulse was not different from wild-types, in either dorsal striatum or nucleus accumbens. However the frequency responsiveness of DA release was slightly modified in A53Tα-syn overexpressors, and in particular showed slight deficiency when the confounding effects of striatal ACh acting at presynaptic nicotinic receptors (nAChRs) were antagonized. The re-release of DA was unmodified after single-pulse stimuli, but after prolonged stimulation trains, A53Tα-syn overexpressors showed enhanced recovery of DA release at old age, in keeping with elevated striatal DA content. In summary, A53Tα-syn overexpression in mice causes subtle changes in the regulation of DA release in the striatum. While modest, these modifications may indicate or contribute to striatal dysfunction.


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- Dirac (2)
- Quanten-Chromodynamik (2)
- heavy-ion collisions (2)
- Dichte (1)
- Elementarteilchen (1)
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- Phase transition in the chiral sigma-omega model with dilatons (1996)
- We investigate the properties of di erent modifications to the linear -model (including a dilaton field associated with broken scale invariance) at finite baryon density and nonzero temperature T. The explicit breaking of chiral symmetry and the way the vector meson mass is generated are significant for the appearance of a phase of nearly vanishing nucleon mass besides the solution describing normal nuclear matter. The elimination of the abnormal solution prohibits the onset of a chiral phase transition but allows to lower the compressibility to a reasonable range. The repulsive contributions from the vector mesons are responsible for the wide range of stability of the normal phase in the (µ, T)-plane. The abnormal solution becomes not only energet- ically preferable to the normal state at high temperature or density, but also mechanically stable due to the inclusion of dilatons. PACS number:12.39.F
- Hypermatter in chiral field theory (1997)
- Abstract. A generalized Lagrangian for the description of hadronic matter based on the linear SU(3)L × SU(3)R -model is proposed. Besides the baryon octet, the spin-0 and spin-1 nonets, a gluon condensate associated with broken scale invariance is incorporated. The observed values for the vacuum masses of the baryons and mesons are reproduced. In mean-field approximation, vector and scalar interactions yield a saturating nuclear equation of state. Finite nuclei can be reasonably described, too. The condensates and the e ective baryon masses at finite baryon density and temperature are discussed.
- Nuclei in a chiral SU(3) model (1998)
- Nuclei can be described satisfactorily in a nonlinear chiral SU(3)-framework, even with standard potentials of the linearmodel. The condensate value of the strange scalar meson is found to be important for the properties of nuclei even without adding hyperons. By neglecting terms which couple the strange to the nonstrange condensate one can reduce the model to a Walecka model structure embedded in SU(3). We discuss inherent problems with chiral SU(3) models regarding hyperon optical potentials.
- Chiral model for dense, hot and strange hadronic matter (1999)
- Introduction: Until now it is not possible to determine the equation of state (EOS) of hadronic matter from QCD. One succesfully applied alternative way to describe the hadronic world at high densities and temperatures are effective models like the RMF-models [1], where the relevant degrees of freedom are baryons and mesons instead of quarks and gluons. Since approximate chiral symmetry is an essential feature of QCD, it should be a useful concept for building and restricting e ective models. It has been shown [2,3] that effective sigma-omega models including SU(2) chiral symmetry are able to obtain a reasonable description of nuclear matter and finite nuclei. Recently [4] we have shown that an extended SU(3) × SU(3) chiral sigma-omega model is able to describe nuclear matter ground state properties, vacuum properties and finite nuclei satisfactorily. This model includes the lowest SU(3) multiplets of the baryons (octet and decuplet[5]), the spin-0 and the spin-1 mesons as the relevant degrees of freedom. Here we will discuss the predictions of this model for dense, hot, and strange hadronic matter.
- Neutron star properties in a chiral SU(3) model (1999)
- We investigate various properties of neutron star matter within an e ective chiral SU(3)L × SU(3)R model. The predictions of this model are compared with a Walecka-type model. It is demonstrated that the importance of hy- peron degrees are strongly depending on the interaction used, even if the equation of state near saturation density is nearly the same in both models. While the Walecka-type model predicts a strange star core with strangeness fraction fS 4/3, the chiral model allows only for fS 1/3 and predicts that 0, + and 0 will not exist in star, in contrast to the Walecka-type model. PACS: 26.60+c, 21.65+f, 24.10Jv
- Superheavy nuclei in a chiral hadronic model (2000)
- Superheavy nuclei are investigated in a nonlinear chiral SU(3)-model. The proton number Z=120 and neutron numbers of N=172, 184 and 198 are predicted to be magic. The charge distributions and alpha-decay chains hint towards a hollow stucture.
- Hadrons in dense resonance matter: a chiral SU(3) approach (2000)
- A nonlinear chiral SU(3) approach including the spin 3 2 decuplet is developed to describe dense matter. The coupling constants of the baryon resonances to the scalar mesons are determined from the decuplet vacuum masses and SU(3) symmetry relations. Di erent methods of mass generation show significant differences in the properties of the spin- 3 2 particles and in the nuclear equation of state
- Critical review of quark gluon plasma signals (2000)
- Compelling evidence for a new form of matter has been claimed to be formed in Pb+Pb collisions at SPS. We critically review two suggested signatures for this new state of matter: First the suppression of the J/psi , which should be strongly suppressed in the QGP by two different mechanisms, the color-screening [1] and the QCD-photoe ect [2]. Secondly the measured particle, in particular strange hadronic, ratios might signal the freeze-out from a quark-gluon phase.
- Nuclei, superheavy nuclei, and hypermatter in a chiral SU(3) model (2001)
- A model based on chiral SU(3)-symmetry in nonlinear realisation is used for the investigation of nuclei, superheavy nuclei, hypernuclei and multistrange nuclear objects (so called MEMOs). The model works very well in the case of nuclei and hypernuclei with one Lambda-particle and rules out MEMOs. Basic observables which are known for nuclei and hypernuclei are reproduced satisfactorily. The model predicts Z=120 and N=172, 184 and 198 as the next shell closures in the region of superheavy nuclei. The calculations have been performed in self-consistent relativistic mean field approximation assuming spherical symmetry. The parameters were adapted to known nuclei.
- Space-time evolution and HBT analysis of relativistic heavy ion collisions in a chiral SU(3) x SU(3) model (2002)
- The space-time dynamics and pion-HBT radii in central heavy ion-collisions at CERN-SPS and BNL-RHIC are investigated within a hydrodynamic simulation. The dependence of the dynamics and the HBT-parameters on the EoS is studied with different parametrizations of a chiral SU(3) sigma omega model. The selfconsistent collective expansion includes the e ects of e ective hadron masses, generated by the nonstrange and strange scalar condensates. Different chiral EoS show di erent types of phase transitions and even a crossover. The influence of the order of the phase transition and of the latent heat on the space-time dynamics and pion-HBT radii is studied. A small latent heat, i.e. a weak first-order chiral phase transition, or a smooth crossover lead to distinctly di erent HBT predictions than a strong first order phase transition. A quantitative description of the data, both at SPS energies as well as at RHIC energies, appears di cult to achieve within the ideal hydrodynamic approach using the SU(3) chiral EoS. A strong first-order quasi-adiabatic chiral phase transition seems to be disfavored by the pion-HBT data from CERN-SPS and BNL-RHIC.

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Where's the best place to buy AR15/M16 kits these days? I'm looking or 7.62x39 AR kits Thanks!
Where's the best place to buy AR15/M16 kits these days? I'm looking or 7.62x39 AR kits Thanks!
ive gotten kits from model 1 sales they might have 7.62x39
dunno if there the best but the qualities good mil spec
and the prices are a lot better than most and i havent had any problems with there service
right now i would say model 1 sales or maybe JT/double-star.
kits are sort of short supply although there are most of the parts around except for barrels.
you might also try del-ton they have good prices and are catching up with the back-orders.
This is probably a ridiculously stupid question, but I have never purchased an AR kit offline. I am looking at the 20" Standard Rifle Kit in 5.45X39. It says that all kits come complete less stripped lower, yet there is no FFL needed? So if I purchase this kit, what else will I need to buy with it? The lower parts kit for the rifle ? Just for some clarification..
"It does not take a majority to prevail...but rather an irate, tireless minority, keen on setting brushfires of freedom in the minds of men." - Samuel Adams
Thats what I thought. Thanks 555
"It does not take a majority to prevail...but rather an irate, tireless minority, keen on setting brushfires of freedom in the minds of men." - Samuel Adams
the 5.45x39 full KIT is going to be tough to find. model one would be the best bet for a kit in that 5.45x39 i would think. you may end up doing what i did buy a barrel and "roll-your own upper"
i built a 5.45x39 car upper with the wilson CAR barrel. it assembled very easy, feeds and functions fine right off the work bench. one of the most straight forward and easy caliber conversions i have ever done for the AR-platform. hell you would think the AR/CAR was made for the 5.45x39--if ya didn't know better.
my 5.45x39 wilson barrel has m4 feed-ramps don't think that the m4 stuff is mandatory for 5.45x39s but all i can say is that this upper really shoots and feeds rounds well so the 5.45x39+m4 ramps is a GO in my book.
7.62x39 i would try model 1, JT/doublestar or maybe del-ton.
my last 7.62x39 CAR has been sort of an ordeal to get running right the del-ton barrel being the biggest PITA. for starters the barrel was threaded wrong at the flash hider, the second problem was the outside finish was all in the inside of the barrel and the barrel was super dirty, took much elbow grease to get that cleaned out, then the gas port in the barrel was just a shade too small. every so often i would get a short stroke. so i pulled the front sight base and very slightly enlarged the gas port.
had some feeding issues finally ended up cutting m4 ramps in the barrel extension.
it is working pretty good now. i am down to the last issue on the 7.62x39 car and it is that it will sometimes get a soft strike on the primer. i have a fix for this though. the bolt/firing pin mod should fix this small issue right up.
Last edited by j427x; 07-02-2009 at 03:58 PM. Reason: how did i get off on 5.45?--LOL


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Diamond Back Cutout Bodycon Dress
Style # 201281
Bold-hued and sexy, this bebe bodycon dress features cool back diamond cutouts and a lightweight stretch fabric that offers a slight sheen. Try it with a pair of studded heels and crossbody back for an effortless look.
- 92% nylon, 8% spandex.
- Center back to hem: 33" (84 cm).
- Machine wash.
- Made in USA.
- Model is 5'9" and is wearing a US size S.
Rated 5 out of 5�by 1 reviewer.
Rated 5 out of 5�by Booski Loveeee Very cute and simple. Fits really great on me, I feel super sexy in it too! October 25, 2012
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Toronto designer and HGTV host Sarah Richardson and her brother, industrial designer Theo Richardson of New York's Rich Brilliant Willing (RBW), explain how their 2011 Interior Design Show concept space came together. Learn how they collaborated on three colour-themed rooms — red, blue and yellow — combining Theo's contemporary lighting and furniture with Sarah's inviting style.
Dining room: Appalachian dining chair, RBW; upholstered chairs, Sarah Richardson Design; Bright Side pendant lights, RBW. Office: Excel Wall Sconce, RBW; Branch Floor Lamp, RBW; Bias Clocks, RBW; high-back diamond tufted chair, Sarah Richardson Design. Bedroom: Clinker Pendant, RBW; Clinker End Table, RBW; French Provençal Daybed, Sarah Richardson Design; upholstered headboard, custom by Sarah Richardson Design.


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Trish Vradenburg on the need to talk about Alzheimer's and the global impact of Alzheimer's (read more).
Must reads
Washington Post editorial highlights negative impact of budget cuts on NIH research, researchers hopeful of Alzheimer's drug therapy within next five years, and Alzheimer's cases set to triple to 135 million by 2050 (read more).
A new era in Alzheimer's research, the link between dementia and exercise, and Selim Zilkha pledges $5 million to USC's Keck School of Medicine to fund a new endowed chair in Alzheimer's disease research (read more).
Alzheimer's death rates doubled in Los Angeles County, Alzheimer's genome sequence data available from the Alzheimer's Disease Sequencing Project, and President Obama and Bill Gates announce major funding push for HIV/AIDS research and prevention (read more).
Leading non-profits push for global action on Alzheimer's ahead of G8 summit on the disease, Alzheimer's rates drop globally, and the link between Alzheimer's and AIDS (read more).


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Athletic Varsity Jacket for ChildrenITEM: 8020C Long-wearing wool blend body (70% wool and 30% nylon) and durable cowhide leather sleeves. Knit collar, waistband and cuffs. Snap front. Fully lined with quilted nylon and poly filled. Made in the USA. Leather clean. Learn More
Boys Luxurious lambskin jacketITEM: 5030 Short in length, long on looks, this jacket features two side slash pockets, plus two zippered pockets concealed by the distinctive flange front and two inside pockets. Leather-covered elastic waist and two-snap cuffs. Poly lined and poly filled. Imported. Leather clean. Learn More
Childrens 3/4 Hooded Leather ParkaITEM: 2330 This rugged 3/4-length leather parka is loaded with pockets—eight outside, two inside. In addition, it features a drawstring waist, detachable hood, snap cuffs and zip-out heavy acrylic pile liner. Imported. Leather clean. Learn More
Childrens 3/4 Length Fringe JacketITEM: 8010C These hip 3/4-length plush suede fringed jackets are an authentic western statement. Five-inch fringe on front and back upper yokes, shoulders and sleeves; four-inch fringed bottom. Three-snap closure. Nylon lined. Imported. Leather clean. Learn More
Childrens A-2 Flight JacketITEM: 1350C Our rugged replica of the original A-2 U.S. Army flight jacket is crafted to last for generations. Two dual entry pockets outside, one inside chest pocket. Warm acetate/nylon lining with poly fill. Ribbed knit waistband and cuffs. Wind flap covers zipper front. Poly lining. Imported. Leather clean. Learn More
Childrens Double Breasted Leather Trench CoatITEM: 3000C In search of value? Look no further than this nappa leather trench coat tailored extra-generously, trimmed with cape back, belted cuffs and shoulder epaulets. Zip-out pile liner with inside pocket opening. Three-button front closure with buckle belt. Back bottom slit with functioning button closure. Two outside slash pockets, leather-trimmed pocket inside. Imported. Leather clean. Learn More
Childrens Genuine Cowhide Leather Motorcycle JacketITEM: 8070C These street-wise motorcycle jackets are handcrafted utilizing only premium-grade leather and trim materials. Classic detailing includes snap-down epaulets and lapel, zippered pockets and five-inch zippered slit sleeve. Comfortable bi-swing back. Front belt. Leather-trimmed inside pocket. Fully lined, poly filled. Imported. Learn More
Childrens versatile all-lambskin leather vestITEM: 4630C What else can spice up a T-shirt, shirt, sweater or sweatshirt with equal style? All-leather and such a good value, you'll want one in every color. For him or for her, each button-front vest is classically styled; his with a front yoke and plain back, hers with a plain front and adjustable back strap. Two front welt pockets, fully poly lined. Imported. Leather clean. Learn More


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FIG. 1 is a upper, side perspective view of a portion of a side of a footwear article; and,
FIG. 2 is a side elevation view of the portion of the side of the footwear article of FIG. 1.
The ornamental design that is claimed is shown in solid lines in the drawings. The broken (dashed) lines shown in FIGS. 1 through 2 are included for the purpose of illustrating environmental elements only and form no part of the claimed design.


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|The most helpful favorable review
|The most helpful critical review
1 of 1 people found the following review helpful:
By DAVID from USA on 2009-02-27 12:08:54Things I liked:every thang!!!i use it bird-rabit and other varmits WICH I LIVE OUT IN THE COUNTRY AND SHOOT A LOT
Things I would have changed:a better scope. such a good gun with such a sucky scope
What others should know:A TOUGH GUN
0 of 0 people found the following review helpful:
By ted from USA on 2007-09-18 22:15:59Things I liked:compaired to other airguns i have owned in the passed the varmint hunter has a very good feel about it. The weight of the rifle is formitable and it has an incredibly realistic recoil. I would find this rifle to be a perfect gun for target practise in suburbia. The power of this gun was surprising for the price at point blank with the light pba ammo (crap only good for short range) it went 2/3 the way threw a 2x4 and at about 10 yards threw a racoon. At close range it is very good at taking care of all those unwanted pest around the house the laser was easy to sight in and is great for close range.
Things I would have changed:the scope is crap the flashlight is poitless and the triger has a very slow action to it
What others should know:this gun is anything but a toy dont buy it for a child. if your an avid shooter u better start workin out cause this thing is a pain to cock. all in all its not a bad buy in my eyes
|By Stanley from USA on 2014-07-18
|By Stanley from USA on 2014-07-18
|By Edith from USA on 2012-06-09
CheckoutSubtotal (USD):
does not include shipping and tax


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A majority of the NC House voted on March 20 in favor of legislation barring children under the age of 18 from entering a tanning bed with or without parental consent.
The house voted 94-22 in favor of the legislation, which will send it on to be voted by the Senate.
The American Cancer Society, medical advocates and child safety advocates have been strong supporters of the legislation claiming that children under 18 are not mature enough to make decisions regarding exposing themselves to high doses of ultraviolet radiation.
"We have the proven research to stand behind this decision, and skin cancer rates have skyrocketed more in younger generations than ever before," said Allison Reeves, community manager for the south Atlantic Division of the American Cancer Society (ACS). "The incidences of melanoma, the most serious form of skin cancer, have risen tremendously in youth and young adults who have used tanning beds."
Reeves said that this effort is similar to the effort that led to the banning of smoking in restaurants, bars and other public places and healthier school lunches.
The legislation would make it illegal for children under the age of 18 to enter a UV tanning bed without a medical prescription.
It is noted that lawmakers have the option of altering the legislation to mimic other states by making it illegal for children 14 and under to use UV tanning unless medically necessary and requiring that children ages 14 to 18 receive parental consent.
North Carolina currently requires that children under 13 are not permitted in tanning beds unless medically necessary, and ages 14 to 18 require parental consent.
While this is a large accomplishment for the ACS there are some small tanning business owners in Yadkinville that are torn about the pending legislation.
"I have mixed emotions on it," said Billy Thomas, owner of Tanzations in Yadkinville. "I believe that it's taking away parental rights, but then again it does need to be regulated with kids 13 and 14 years old."
Thomas said that most of his underage customers are between the ages of 16 and 18 and tend to tan around events like homecoming and prom and then stop tanning following the event.
Reeves said that although many teenage tanners are only tanning around special events it doesn't necessarily lessen their chances of developing melanoma.
"We have to push for this for the sake of our children," Reeves said. "They should be 18 years old and be able to make an informed decision before getting into a tanning bed. Too many are getting in there, simply because they want to be tan for the prom, the homecoming dance, etc. We do not make these decisions lightly."
Reeves and Thomas agree that the tanning industry has been moving toward spray tanning in the past few years to address the growing problem with skin cancer. Reeves encourages that teens and anyone wishing to have the summer glow use this method since it is reportedly much safer than UV tanning.
"The tanning industry has already begun to transition to spray on tans," Reeves said. "They have proven to be safer and just as effective as tanning beds without the negative health consequences. Spray tans are more cost effective as well. Since the industry is already making this transition to a more effective business model, we do not anticipate a large loss of business for the tanning industry."
Thomas said that his business is aware of this change, and he too is looking into offering the service for his customers.
"We have been looking into spray tans for this very reason," Thomas said. "We're debating whether we want to do an automated spray tan machine or someone who will apply the tan for the customer. We'll probably be offering that by the end of this season."
In the meantime Thomas says that he knows that should this legislation pass in the Senate he expects it will affect his business somewhat. He hopes that legislators will consider a lighter regulation on tanning rather than a full-scale ban.
"Maybe they could just limit how many times they can go a week because they definitely don't need to be going every day," Thomas said. "But at least here they can be regulated, whereas they can go to the beach and lay out in the sun for several hours at a time. I make sure that my employees get educated and certified before they work here so that they can make sure our customers are being safe with their tanning."
Reeves said that she expects the Senate to also get behind this legislation and said that ACS volunteers have been very vocal and visible with house and congress members so they make an informed decision when they vote.
"I'm hopeful we will see the same result in the Senate," Reeves said. "We had several volunteers attending Lobby Day in Raleigh a couple weeks ago, and they had warm receptions by those they were able to speak with. I'm hoping that was a good sign. We feel confident that the Senate will take up this issue and vote favorably on it, especially since the House showing of support was so strong."
Reach Lindsay Craven at 679-2341 or at firstname.lastname@example.com.


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Premier League champions Manchester United had four players selected for the team of the year by the Professional Footballers' Association.
Goalkeeper David De Gea, defender Rio Ferdinand. midfielder Michael Carrick and forward Robin van Persie were all selected by their peers as the best players in their positions.
Chelsea had midfielders Eden Hazard and Juan Mata chosen, and Tottenham Hotspur central defender Jan Vertonghen and Gareth Bale were both included in the 11.
Manchester City's dependable full-back Pablo Zabaleta, Leighton Baines of Everton and, controversial forward Luis Suarez, of Liverpool, made up the stellar line-up.
Zabaleta tweeted: "Truly humbled to be included within the @PFA Team Of The Year. It's an honour to play and be named alongside such great players. Thanks."


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Thu., Feb. 17
at Houston Aeros
Toyota Center
11 a.m.
Fri., Feb. 18*
at Rockford IceHogs
Rockford MetroCentre
7 p.m.
Sat., Feb. 19^
vs. Texas Stars
Allstate Arena
7 p.m.
*Comcast Network 100
Log on to chicagowolves.com for broadcast schedule, or to watch or listen to the action live online
The Wolves have potted 14 goals in their last three games after bagging only six markers in their previous three outings; Chicago is averaging 3.25 goals-per-game this year, which ranks sixth in the AHL.
--- Darren Haydar: Shared the team lead with four points (2G, 2A) in two games last week ... Paces the Wolves and shares fifth in the AHL with 51 points in 53 games this season ... Ranks second on Chicago and is tied for 11th in the league with 20 goals and holds second on the team and shares ninth in the AHL with 31 assists ... Collected multiple-points in three of his last four outings
--- Nigel Dawes: Collected three points (2G, A) in two games last week, which includes his ninth multiple-point game this season on Friday (G, A) ... Ranks first on the Wolves and third in the league with 25 goals and shares third on the team and 18th in the league with 42 points in 46 games this season ... Registered three goals and five points during a current three-game point-streak
--- Mark Matheson: Shared the team lead with four points (G, 3A) in two games last week, which includes matching a season-high three assists on Wednesday ... Ranks second among Chicago defensemen with 17 assists and 21 points in 47 games this season ... His 21 points hold eighth overall on the Wolves ... Leads team blueliners and ranks second on the squad with a +10 plus/minus rating
--- Jaime Sifers: Dished out four assists in his last three games, which includes accruing two helpers on Friday ... Ranks third among Chicago defensemen with 11 assists and 14 points in 44 games this season ... Ranks third on the Wolves with a +8 plus/minus rating
--- Jason Krog: Tallied three assists in his last three games ... Ranks second on the Wolves and eighth in the AHL with 48 points in 56 games this season ... Leads Chicago and ranks third in the AHL with 37 assists ... Is one of just two Wolves to have appeared in every game so far this season
--- Chicago, which has won its last two outings against West Division opponents, sits in seventh place in the West Division with 60 points (27-23-2-4) through 56 games this season; the Wolves trail the first place Houston Aeros by eight points.
--- Chicago has not been outshot by an opponent in seven straight contests; the Wolves have notched a 13-12-0-1 mark when outgunning opponents this season.
--- Left wing Fredrik Pettersson has posted four points (G, 3A) in his last five games after netting four points (G, 3A) in his previous 13 outings; the 23-year-old forward holds eighth on the Wolves with 13 assists and ninth with 19 points in 43 games this season.
--- The Wolves have scored multiple power-play goals in a game 15 times this season, which includes netting two on seven chances on Wednesday; Chicago has scored a league-high 57 man-advantage markers this season, and ranks fourth in the AHL with a 21.8 power-play rating (57 of 262.)
--- The Wolves have been perfect on the penalty kill in three of their last four matchups, which includes blanking Milwaukee on two chances on Friday; Chicago ranks 30th in the league with a 76.5 percent efficiency rating on the penalty kill overall this season (199 of 260).
--- Wolves left wing Andrew Kozek will visit the Oak Lawn Public Library, 9427 S. Raymond Ave., on Tue., Feb. 15, at 4 p.m., and the Palos Heights Public Library, 12501 S. 71st St., at 7 p.m., as part of the team's "Read to Succeed" program, presented by Vista Health System, Pace and Butternut Bread. Members of the squad will make library visits throughout the Chicago area this season for the program, which has reached more than 550,000 children since its inception in 1995.
Fri., Feb. 11
Chicago 5, (at) Milwaukee 2
--- The Wolves broke a 1-1 tie with five straight goals, picking up an eventual 5-2 win in an Amtrak Rivalry matchup against the Milwaukee Admirals at the Bradley Center
--- Forwards Darren Haydar, Fredrik Pettersson, Tim Miller and Nigel Dawes and defenseman Mark Matheson lit the lamp for the Wolves
--- Goaltender Peter Mannino thwarted 24 of 26 shots
Wed., Feb. 9
Grand Rapids 7, (at) Chicago 5
--- The Wolves rallied with four third-period goals but it wasn't enough as Grand Rapids slipped by with a 7-5 win at the Allstate Arena
--- Forwards Nigel Dawes, Riley Holzapfel, Andrew Kozek, Ryan Garbutt and Darren Haydar scored
--- Goaltenders Drew MacIntyre (15-19) and Peter Mannino (11-13) split time in MANNINO's loss


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Any expert saxophonist or clarinetist will tell you how essential a quality reed is to their sound and tone. In fact, you won't find many players who don't have at least one extra reed close by during a performance. Along with the mouthpiece, the role of the reed is crucial to the overall functionality of your instrument. For that reason, it only makes sense to equip yourself with a reed that's high in quality, and consistently used by the world's best player. In other words, it only makes sense to go with Rico. When it comes to woodwind reeds and accessories, Rico's reputation is continuously growing. Every day, both novice players and seasoned experts are experiencing the smooth and easy playability of a Rico reed and mouthpiece.
For saxophones, the Rico Alto saxophone reed is a popular item and used in a wide variety of situations. Cut from the most flexible grade of cane, these reeds are affordable, smooth to play, and consistently used by music teachers and professional musicians from around the world. The same thing can also be said for Rico Bb clarinet reeds. The world's most popular reed, these reeds come highly recommended for their astounding ease of play and incredible value.


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Art Supplies
These high quality, popular colored pencils are available in more places in the U.S. than any other colored pencil. Colors include primary hues, midtones, grays, neons and metallics.
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Questions & Answers
Do you have questions about this product?
Get answers from real customers and in-house experts with AnswerBox.
Q:A lot of lipstick tutorials say you should line your lips with a lipliner and then /fill in/ your lips with that lipliner before applying lipstick on top of that to make it last longer. Is that recommended for Decisive, or would it last longer on pure naked lips?Asked on 7/22/2013 by D-Money from Wilmington, DE
2 answers
A:The Emotional Brilliance colors are very pigmented and last a long time, so it is definitely not necessary to line your lips ahead of time.Answered on 10/4/2013 by Kendra M from LUSH Direct
A:I think that these lip colors are long lasting, however, I have found that it bleeds a bit. Therefore, I would recommend a lipliner to help prevent that.Answered on 7/25/2013 by Hello Miss Niki from New York City, NY
Q:Is this color good with an olive complexion?Asked on 10/25/2012 by roguetamlin from Somerville MA
1 answer
A:Since the Emotional Brilliance line is catered to choosing color depending on the mood you are in, we do not necessarily recommend color based on complexion. That being said, we have received positive customer feedback on Decisive from lots of customers with varying complexions so it would likely look lovely with an olive skin tone!Answered on 11/7/2012 by Melissa S from LUSH Direct


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Wind: 0 mph
By Jennifer Stella
As with so many other projects in our community, the Waitsfield School's Safe Routes to School (SRTS) committee is 100 percent volunteer and I participate. Over the last few years, our SRTS team has been instrumental in identifying, communicating and finding solutions to the safety issues faced by our young families and children who wish to bike or walk to school. In our surveys of young families in Waitsfield, top safety concerns have consistently been speed of traffic along Route 100, volume of traffic along Route 100 and lack of sidewalks/paths. Our most recent survey was in 2012 and 60 families responded.
The Waitsfield SRTS team has worked to help the town secure funds to enhance safety for pedestrians and bicycles through the village for the last few years. SRTS-related grants include a $141,000 infrastructure grant in 2010 to design and implement safety improvements, which was spent on new radar feedback signs meant to slow traffic and designs for a crosswalk in front of the school and a $250,000 SRTS grant was accepted by the town in 2012 (100 percent reimbursed) to construct a new segment of sidewalk on the west side of Route 100 from Old County Road to Valley Players Theater. This money is listed in Waitsfield's capital budget as $125K to spend in 2013 and $125K to spend in 2014.
In 2013, the town applied for funding through VTrans Bike and Pedestrian Program to design and construct a sidewalk along VT 100 from Valley Players to Farr Lane. Our SRTS team sent a letter of support for this application, which was joined with strong letters of support from the chair of Waitsfield's Select Board, Mad River Path Association, MRV Health Center, Waitsfield's Planning Commission, Chamber of Commerce, MRV Planning District and Central VT Planning Commission. Selected from among 30 applications statewide, Waitsfield was offered 90 percent reimbursement of up to $369,500 to construct sidewalks on the west side of Route100.
On October 14, the Waitsfield Select Board reviewed whether to accept the $369,500 grant and sign the grant assessment for additional sidewalks. Several property owners adjacent to the proposed sidewalk and present at the meeting expressed concerns over engineering, budgeting and the impact that construction of the project might have on nearby properties. The select board heard vocal support in favor of sidewalks by the SRTS team and many of the same property owners.
In the end, the select board voted not to accept the $369,500 grant to build sidewalks from Valley Players to Farr Lane, but the town still needs (and landowners support) safer sidewalk and crosswalk connections in our village.
Perhaps we should consider doing it all on our own without external funding and associated design requirements. Do we have the budget and the will?
Stella lives in Waitsfield.


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BR10824 In Stock
Make your own beaded bracelet with Eve's Addiction' Pandora Charm Compatible Bangle Bracelet with Barrel Clasp. The silver plated bracelet is 7.5" around and fits any of our Pandora compatible Oriana beads. Choose themed beads, birthstone beads or unique beads to add to the bead bangle bracelet. The bangle is Pandora bead compatible, so you can mix and match with the beads you already have. Each bangle bracelet with barrel clasp is delivered in an Eve's Addiction gift box.
Eve's Addiction.com wants you to be a happy customer. We want you to be completely satisfied with the sterling silver jewelry that you receive from us, as we only sell high quality silver and cubic zirconia cz jewelry. We do understand that you may not like your purchase for some reason.
You may return or exchange your jewelry within 60 days of purchase if you are not satisfied with it. The jewelry must be returned in its original condition for a refund or exchange. Engraved, personalized, photo, monogram, name and initial, chocolate and clearance items are not returnable or exchangeable.


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This modern Cooking Center provides the perfect setting for creating culinary masterpieces! It features an oven with temperature and timer controls, a built-in refrigerator, a washing sink and steam hood. The fun will never end when your child is playing with the Wonderworld Cooking Center Play Kitchen Set!
Wonderworld uses only water-based non-toxic paints and lacquers, and rubber-wood, a renewable resource, to demonstrate their commitment to your child's safety and Mother Earth.
Note: Utensils and food accessories sold separately.
- Dimensions: 35" x 70" x 91"
- Ages: 3 years & up
Gift Wrap not available.


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|Physical Therapy, Occupational Therapy and Speech Pathology
Physical Therapy, Occupational Therapy or Speech Therapy can often be helpful for patients who are recovering from an illness, injury or surgery.
At Saint Francis, "getting well," means getting you back to doing the things you love to do whenever possible. Therapy services can help patients build strength, increase their functional abilities and improve their quality of life.
Physical therapy focuses on building strength, flexibility, coordination and balance.
Physical therapy almost always includes exercise. It can include stretching, core exercises, weight lifting, and walking.
Occupational therapy focuses on the ability to perform daily activities of living. Occupational therapists work with patients who may need help with skills that help them remain independent like dressing and eating, home skills like cooking and driving or personal management skills like balancing a checkbook. Occupational therapists can help individuals find adaptive ways to do these daily tasks if needed.
Speech therapists work with patients whose illness has affected their speech or ability to swallow. Speech therapists analyze and diagnose the nature and extent of a patient's speech, language and swallowing issues and then develop a specialized treatment plan that fits each patient's own unique needs.
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|Patient & Visitors Guide | Amenities & Services | Insurance & Billing | Gifts & Greetings | Medical Records | Pastoral Services
|Mission, Vision & Values | Media Relations | Awards | Corporate Responsibility
|Patient Privacy | Patient Rights | COI Policy | Disclaimer
©2014 CHI Health St. Francis. All Rights Reserved.
2620 West Faidley Ave. Grand Island, NE 68803 | (308) 384-4600


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The Yadkin County Farm Bureau presented its 2012 annual awards in December 2012.
The following individuals were honored by the Farm Bureau for their outstanding dedication to agriculture.
County Manager Aaron Church was recognized by Yadkin County Farm Bureau President Justin Somers with the Distinguished Service to Agriculture Award. Church was applauded for his recent work on a county agricultural center, and representing Yadkin County agriculture in positive way while writing applications to the Gold Leaf Foundation and the NC Tobacco Trust Fund.
The Distinguished Service Award is awarded to a resident or non-resident of Yadkin County. For a non-resident to be considered, his or her "work" will have to impacted Yadkin County agriculture/farming in a positive way. It most cases the individual may not be actively involved in the production of agriculture himself of herself. However, through their efforts they have had a positive effect on the agriculture industry and Yadkin County specifically. Individuals involved in production agriculture or agribusiness can be considered.
Leneul Chamberlain was recognized by Yadkin County Farm Bureau President Justin Somers with the Excellence in Agriculture Award. Chamberlain was recognized in part to his dedication to agriculture and spreading the word to all the importance agriculture plays in the lives of each individual. Chamberlain opens his farm and his Lone Hickory Arena to numerous children annually.
The Excellence in Agriculture Award is awarded to a farmer, full time or part time, traditional or non-traditional operation, or someone involved in agribusiness. The recipient must live in Yadkin County. The candidate goes above and beyond in the promotion of farming and agriculture and the impact it plays on every individual's daily lives and routines. There will be one awarded each year at the County Farm Bureau Annual Meeting.
Jonesville Insurance Agent James Doll was recognized by Yadkin County Farm Bureau President Justin Somers with the Service Excellence Award. Doll was recognized in part for his over 20 years with Farm Bureau, excellent customer service and understanding of "One Farm Bureau… One Mission," including county Farm Bureau activities, state Farm Bureau activities and excelling in his position with the NC Farm Bureau Mutual Insurance Company.
The Service Award is awarded to an agent, associate agent or CSR that best understands and promotes the total Farm Bureau Package. There will be one awarded each year at the County Farm Bureau Annual Meeting.
Yadkin County Farm Bureau Past Presidents Jack F. Shore and Bobby J. Matthews Jr. were recognized by Yadkin County Farm Bureau President Justin Somers for their years of service to the organization. Shore served as president from 1987-2004 and Matthews served as president from 2005-2009. Both continue to serve on the Yadkin County Farm Bureau board of directors. Shore is also a member of the NC Farm Bureau board of directors.


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A 14K yellow-gold pendant set with one raised Hawaiian Black Coral freeform "S"-shaped stone, 16x5mm, three faceted round Diamonnds totaling 0.04 carats, total weight, without chain. Approximately L: 1 1/4" W: 3/8"
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Luke Barnatt wants Carmont, 'TUF' coaching gig, to be face of European MMA
*Follow the link for the video.Luke Barnatt has some lofty goals, but he can state each one including a desired fight with fellow middleweight Francis Carmont with remarkable clarity.
The 25-year-old English fighter, who appeared on The Ultimate Fighter 17, wants Carmont (22-8 MMA, 6-1 UFC) for two reasons: Barnatt (8-0 MMA, 3-0 UFC) thinks he can put on an exciting fight with the grinder, and he thinks a win would move him up the rankings.
Hes a big guy just like me, Barnatt recently told MMAjunkie. But youve seen my output. I have a very, very high output. And Francis is a bit slower. Hes very powerful and a strong guy, but I just feel like stylistically, its an exciting fight. Hes a top-10 guy. Hes a guy I could take on, and itd be a very, very big step up for me, and an exciting step.
He doesnt push for the finish. All I do is look for the finish.
Barnatt also explains why he wants to be a TUF coach and how European MMA can eventually get to the level seen in the U.S.
** Good move by Barnett with Siver out of the scene for a while.


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Simply Nourish™ Senior Dog Food - Natural, Chicken & Brown Rice
Help keep your senior dog healthy and happy with this specially formulated food that is fortified with vitamins and minerals to deliver wholesome nutrition and a taste your dog will love. This Simply Nourish Chicken & Brown Rice Recipe Senior Dog Food offers balanced nutrition to help your dog thrive. The vitamins and minerals offer essential nutrients to help your senior dog stay healthy and active, while the delicious real-chicken taste is sure to keep him or her coming back for more.
Food Type: Dry Food
Food Consistency: Kibble
Life Stage: Senior
Health Consideration: Cardiac
Flavor: Chicken & Brown Rice
Primary Ingredient: Chicken
Nutrition Option: Natural
Package Weight: 6 lbs
Chicken, Oatmeal, Brown Rice, Chicken Meal (Source of Glucosamine and Chondroitin), Barley, Rye, Tomato Pomace, Natural Flavor, Canola Oil (Preserved with Mixed Tocopherols), Dicalcium Phosphate, Flaxseed, Rice Bran, Calcium Carbonate, Dried Chicory Root, Dried Carrots, Dried Spinach, Dried Sweet Potatoes, Dried Pumpkin, Dried Blueberries, Potassium Chloride, Zinc Sulfate, Ferrous Sulfate, Copper Sulfate, Manganese Sulfate, Calcium Carbonate, Sodium Selenite, Vitamin E Supplement, L-Ascorbyl-Polyphosphate, Niacin, D-Calcium Pantothenate, Vitamin A Supplement, Riboflavin, Pyridoxine Hydrochloride, Thiamine Mononitrate, Calcium Iodate, Folic Acid, Biotin, Vitamin D Supplement, Vitamin B12 Supplement and Choline Chloride
Guaranteed Analysis:
Crude Protein (min) 19.0%
Crude Fat (min) 8.0%
Crude Fiber (max) 5.0%
Moisture (min) 10.0%
Calcium (min) 1.0%
Phosphorus (min) 0.8%
Potassium (min) 0.6%
Zinc (min) 175mg/kg
Selenium (min) 0.30 mg/kg
Vitamin A (min) 20,000 IU/kg
Vitamin E (min) 200 IU/kg
Omega-6 Fatty Acid* (min) 2.0%
Omega-3 Fatty Acid* (min) 0.2%
Ascorbic Acid* (Vitamin C) (min) 10 mg/kg
Glucosamine* (min) 400mg
Chondroitin* (min) 300mg
*Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profiles.
$ 6.99
$ 19.99
$ 84.99 to $ 129.99
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HPS723 - Organisational Placement 1
Unit details
|2015 unit information
|Enrolment modes:
|Trimester 1: Burwood (Melbourne)
Trimester 2: Burwood (Melbourne)
|Credit point(s):
|EFTSL value:
|Unit chair:
Vanessa Sturre
|Incompatible with:
|Contact hours:
Placement hours negotiated between student, university supervisor and placement site.
This unit fosters professional skills and awareness of professional issues in applied settings. Prior to their first placement, students are required to participate in a placement preparation activity designed to enhance placement planning and student development. Following this, each student will be assigned a first placement in an organisation, which will expose students to the workings of an organisation and the types of issues that arise in an organisational psychological context. The placement will be based on short and well-defined activities that students can complete for the organisation within a specified time period. The broad features of the activities will be negotiated with the organisation prior to the placement, with final details being agreed to by the student and the organisation within the first week of the placement. The project/activity will be directly relevant to organisational psychology and will relate to a concern that the organisation wishes to address.
An ungraded pass is awarded for successful completion of the placement unit and its components. Satisfactory completion of the unit involves the following components:
- Assessment task 1: Satisfactory contribution and participation in pre placement scoping activities (e.g., development and assessment centre, meetings/discussion with Placement Coordinator/s, or alternative tasks);
- Assessment task 2: Attendance for agreed length of placement to an assigned organisation;
- Assessment task 3: Satisfactory completion of a project and/or placement activities aligned to organisational psychology;
- Assessment task 4: Satisfactory presentation of the logbook. This is a professional document required for registration purposes and must be maintained to an appropriate standard in terms of content and presentation. The content should be in the form of advanced discussion of placement activities accompanied by in-depth reflections;
- Assessment task 5: Satisfactory completion of the placement unit within the relevant University trimester time-frames;
- Assessment task 6: A report indicating satisfactory professional and ethical competence of the student from the Organisation Supervisor and the Deakin Supervisor, and
- Assessment task 7: Satisfactory participation in group and individual supervision sessions.
If there is uncertainty regarding the satisfactory completion of any of the above components or if student competence is questioned, the Deakin Supervisor/Unit Chair(s) will review and determine the outcome.
Failure to complete the requirements of any one component satisfactorily will result in the student failing the assessment. Failure of a placement unit may lead to enrolment in the course being revoked.
Unit Fee Information
|Student Contribution Rate*
|Student Contribution Rate**
|Fee rate - Domestic Students
|Fee rate - International students
* Rate for all CSP students, except for those who commenced Education and Nursing units pre 2010
** Rate for CSP students who commenced Education and Nursing units pre 2010
Please note: Unit fees listed do not apply to Deakin Prime students.


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Trachoma (truh-KOH-muh) is a bacterial infection that affects your eyes. The bacterium that causes trachoma spreads through direct contact with the eyes, eyelids, and nose or throat secretions of infected people.
Trachoma is very contagious and almost always affects both eyes. Signs and symptoms of trachoma begin with mild itching and irritation of your eyes and eyelids and lead to blurred vision and eye pain. Untreated trachoma can lead to blindness.
Trachoma is the leading preventable cause of blindness worldwide. The World Health Organization (WHO) estimates that 8 million people worldwide have been visually impaired by trachoma. WHO estimates more than 84 million people need treatment for trachoma, primarily in poor areas of developing countries. In some of the poorest countries in Africa, prevalence among children can reach 40 percent.
If trachoma is treated early, it often may prevent further trachoma complications.
The principal signs and symptoms in the early stages of trachoma include:
As the disease progresses, later trachoma symptoms include:
Young children are particularly susceptible to infection, but the disease progresses slowly, and the more painful symptoms may not emerge until adulthood.
The World Health Organization has identified a grading system with five stages in the development of trachoma, including:
All the signs of trachoma are more severe in your upper lid than in your lower lid. With advanced scarring, your upper lid may show a thick line. In addition, the lubricating glandular tissue in your lids — including the tear-producing glands (lacrimal glands) — can be affected. This can lead to extreme dryness, aggravating the problem even more.
Call your doctor if you or your child has itching, irritation or discharge from the eyes, especially if you recently traveled to an area where trachoma is common. Trachoma is a contagious condition, and it should be treated as soon as possible to prevent further infections.
Trachoma is caused by certain subtypes of Chlamydia trachomatis, a bacterium that can also cause the sexually transmitted infection chlamydia.
Trachoma spreads through contact with discharge from the eyes or nose of an infected person. Hands, clothing, towels and insects can all be routes for transmission. In the world's developing countries, flies are a major means of transmission.
Factors that increase your risk of contracting trachoma include:
One episode of trachoma caused by Chlamydia trachomatis is easily treated with early detection and use of antibiotics. However, repeated infection can lead to complications, including:
You're likely to start by seeing your family doctor or a general practitioner if you have symptoms of trachoma. However, in some cases when you call to set up an appointment, you may be referred immediately to an eye specialist (ophthalmologist).
Because appointments can be brief, and because there's often a lot to talk about, it's a good idea to be well prepared. Here's some information to help you get ready, and what to expect from your doctor.
Your time with your doctor is limited, so preparing a list of questions will help you make the most of your time together. List your questions from most important to least important in case time runs out. For eye irritation, some basic questions to ask your doctor include:
In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions during your appointment at any time that you don't understand something.
Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over points you want to spend more time on. Your doctor may ask:
While you are waiting for your appointment, practice good hygiene to reduce the possibility of spreading your condition:
Most people with trachoma in its initial stages display no signs or symptoms. In areas where the disease is common, your doctor can diagnose trachoma through a physical examination or through sending a sample of bacteria from your eyes to be cultured and tested in a laboratory.
Trachoma treatment options depend on the stage of the disease.
In the early stages of trachoma, treatment with antibiotics alone may be enough to eliminate the infection. The two drugs currently in use include a tetracycline eye ointment and oral azithromycin (Zithromax). Although azithromycin appears to be more effective than tetracycline, azithromycin is more expensive. In poor communities, the drug used often depends on which one is available and affordable.
The World Health Organization (WHO) guidelines recommend giving antibiotics to an entire community when more than 10 percent of children have been affected by trachoma, to treat anyone who has been exposed to trachoma and reduce the spread of trachoma.
Treatment of later stages of trachoma — including painful eyelid deformities — may require surgery. WHO guidelines recommend surgery for people with the advanced stage of trachoma.
In eyelid rotation surgery (bilamellar tarsal rotation), your doctor makes an incision in your scarred lid and rotates your eyelashes away from your cornea. The procedure limits the progression of corneal scarring and can help prevent further loss of vision. Generally, this procedure can be performed on an outpatient basis and often significantly reduces the chances of trachoma returning.
If your cornea has become clouded enough to seriously impair your vision, corneal transplantation may be an option that may improve vision. Frequently, however, with trachoma, this procedure doesn't have good results.
You may have a procedure to remove eyelashes (epilation) in some cases. However, this procedure may need to be done repeatedly. Another temporary option, if surgery isn't an available option, is to place an adhesive bandage over your eyelashes to keep them from touching your eye.
If you're traveling to parts of the world where trachoma is common, be sure to practice good hygiene to prevent infection.
If you've been treated for trachoma with antibiotics or surgery, reinfection is always a concern. For your protection and for the safety of others, be sure that family members or others you live with are screened and, if necessary, treated for trachoma.
Proper hygiene practices include:
Although no vaccine is available, trachoma prevention is possible. The World Health Organization (WHO) has developed a health strategy to prevent trachoma, with the goal of eliminating trachoma in the world by 2020. The strategy is titled SAFE, which includes:
Original article: http://www.mayoclinic.org/diseases-conditions/trachoma/basics/tests-diagnosis/CON-20025935
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Frank Lewis
PDT Staff Writer
Lorain County has decided to implement a Naloxone program modeled after Scioto County's "Project D.A.W.N. (Deaths Avoided With Naloxone)." The project was named after Leslie Dawn Cooper, a local woman who lost her life to prescription drugs.
Naloxone is a drug that has been used by emergency responders and hospitals for several years, to reverse the effects of an overdose. Lisa Roberts, RN, of the Portsmouth City Health Department said Naloxone has no potential for abuse; that it's a safe drug and a harmless drug, and it can be administered inter-nasally by people who are minimally trained, when they are in a situation where somebody is overdosing.
"We got to be the pilot county for Ohio's first Naloxone program," Roberts said. "So we got to the the first county to implement this under a pilot project, which means that we start it; set the example; we develop all of the protocols and we try it out. Then, based on our success, other counties then can adopt our program."
The seed money for the program locally was $40,000 from the Ohio Department of Health.
Lorain's overdose death toll tripled last year to 60, up from 22 in 2011. Dr. Stephen Evans, the Lorain County Coroner, said at least 16 of the 60 deaths came when the victim shifted from expensive prescription drugs to heroin, a much cheaper and much stronger counterpart. The first initiative to combat the trend is to put Naloxone into the hands of non-medical first responders, mainly police officers and in some cases family members. A Lorain County think tank has looked at Scioto County's "Project D.A.W.N."
"A while back, Lorain County scheduled a conference call with me, and we did it on a computer," Roberts said. "And they were telling me that they were also now seeing these really high rates of overdose in Lorain County. Basically, what happened was that when Scioto County squeezed, Northern Ohio bulged. So now, northern Ohio is just being really hard hit, like southern Ohio. It has gotten so much worse up there."
The "squeeze" is in reference to the the closing down of all Scioto County pain clinics and the overall war on illegal drugs in Scioto County. The "bulge" means that much of the drug problem moved north.
The City Health Department, operating the Project D.A.W.N. program, has, so far, given out 80 overdose reversal kits at no charge. Roberts said, so far, five lives have been saved locally with the use of Naloxone.
Roberts said recently NADDI (National Association of Drug Diversion Investigators) came out with a statement that they endorse the Naloxone program, and that they want law enforcement to be able to have the kits in the hands of all first responders. She said there remains numerous things in the way blocking the program nationally, and those things have yet to be addressed legislatively.
Roberts said there is also a Draft Bill that is in the Ohio Legislative Commission now that is possibly going to be introduced in the near future which expands access to Naloxone and provides civil immunity to certain people who use it to attempt to reverse an opioid overdose. According to Roberts, Ohio Representative Michael Stinziano (D-18) is considering introducing the legislation, and Rep. Dr. Terry Johnson (R-90) is also considering co-sponsoring that bill.
"We are also working with the Office of National Drug Control Policy to expand access to Naloxone at the national level," Roberts said. "The drug czar, Gil Kerlikowski, is definitely in favor of making Naloxone widely available in an effort to thwart the fatal overdose epidemic. (Portsmouth Health Commissioner) Chris Smith and myself were a part of a roundtable in Washington D.C. this past December, and will be working with ONDCP in the near future to address this at the national level. They are planning to hold Congressional Hearings sometime this year."
Roberts said Cincinnati health officials will be in town next week to discuss the program and how that city might also implement a similar program in the future.
Frank Lewis may be reached at 740-353-3101, ext. 252, or at firstname.lastname@example.com.


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American on the Move is an evidence-based nonprofit dedicated to helping you take small steps and make small lifestyle changes for a healthier way of life. This website will help you improve your health and quality of life through healthful eating and active living. Includes an online community, articles on making healthy choices, and more. En español
America on the Move (AOM)
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Go4Life-National Institute on Aging (NIA)
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BlueCross BlueShield Association
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