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Tuesday, February 19, 2013
It's not a kept secret in regard to my feelings about clowns.
I saw a sign this weekend saying the circus was in town. A chill of fear crept up my spine.
I don't like clowns. They scare me.
I was the fearful child, riddled with neuroses and phobias, cursed with the wild imagination that rendered all impossible and improbable things a definite possibility and an absolute certainty.
What is it about clowns, anyway?
It's their freakishly long, water-ski feet, the wild orange hair and the big red ball nose, the leering, white faced grin spreading from ear to ear as if deliciously pondering the notion of what it would feel like to devour your soul as you slept.
It's the tall clowns on stilts, rising to the Big Top rafters, and especially the short clowns, running everywhere, falling down and then bouncing right back to their feet as if they were made out of rubber.
Clowns are not the representation of the hidden sad face, clowns are pure evil incognito.
Clowns do not speak – another thing I don't like. Mime clowns, the worst kind.
A friend of mine asked me, how do you ever eat at McDonald's?
It wasn't easy. I kept my eyes downcast, staring at the floor, repeating the same mantra over and over again, "Don't make eye contact with the clown… don't make eye contact with the clown."
And if the clown doesn't get you, the talking Big Mac head will.
Puppets get me almost as much as clowns do. Puppets are merely clowns on strings. And the whole frog and pig love thing going on with the Muppets. Creepy.
I don't like mimes, either. Mimes are evil cousins to the clown.
Mimes are patient, deathly pale in pallor, regarding you with that silent open-eyed stare of curious mockery, silently waiting for you to make a mistake while seemingly trapped inside their invisible boxes. And when you do, they will pounce on you in droves to attack and pretend to beat the snot out of you.
I was in Walmart the other day and saw a mother demonstrating the fun of a Jack-in-the-box to her two year old. Here, crank the little knob and a pretty little song plays.
Then, just as you're enjoying the song, perhaps even singing along, you get to the end and "POP!" goes the weasel and a dismembered clown head on a spring jumps out of the box at you.
The only reason no one in Walmart could hear the kid crying was because I was screaming like I'd just lost my legs.
My aunt had several Red Skelton clown paintings hanging in her living room, and one in particular, a painting called "Cloud Clowns" that showed the clouds forming into dozens of clown faces.
Hideous it was.
For years I had trouble even looking up at the sky for fear of what might be looking back at me.
My clown dreams though rank right up there with tornadoes and giants as all-time favorite nightmares. Friends of mine know this, and Carma, a good friend of mine last night brought up an interesting scenario.
"Think about it," she said, "A tornado forms from a cloud ... from a clown in the clouds."
A tornado with a leering clown face coming at you, Carma said, and chuckled.
An evil woman you are.
Probably a clown spy in disguise too, I'll bet. Oh yeah. I'm sleeping with the lights on tonight.
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Media Player
posted on Nov 20th
What happened to Kennedy's car?, Gov't complex for deaf discriminates non-deaf?, Former Pres Bush and Bill Cosby on late night shows & "Black Zombie"
- Brewers lose to Giants, 5-0 5:53pm
- Timber Rattlers down Peoria 6:41am
- Brewers top the Giants 12:05am Jul 28
- Giants knock off the Brewers 12:09am Jul 25
- Brewers shutout by Diamondbacks 10:09pm
- Nelson and Braun lead Brewers past Diamondbacks 2-1 12:21am
Training camp is here! In a few weeks, the preseason will roll out and before we know it, the regular…
posted by Justin Hull 13 hours ago
The Timber Rattlers have won four games in a row, which is their longest winning streak of the year. They…
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Think a chlorinated pool is safe, sterile place? Think again. There are a few dangers lurking in a shared pool,…
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|Summary of Modification for PEAHIRE
Version 8.8.A - This is a Banner baseline form has been modified by OUS to provide consistency in Jobs creation when using EPAF, NBAJOBS or PEAHIRE. The heart of the modification requires passing four new parameters to the p_calc_compensation_fields procedure. The new parameters are: Annual Basis, Annual FTE, Annual Salary Rate and Employee Class Per Pay Hours. The first three parameters are also displayed in the PEAHIRE Jobs block to show users that with the OUS mod more input data is required to set up a Job record via PEAHIRE.
[Return to New Release Modifications List]
Contact: Controller's Division
URL: http://www.ous.edu/cont-div/bsfs/hrvermgt.htm


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mission of the Illinois Nature Preserves Commission (INPC) is to assist
private and public landowners in protecting high quality natural areas
and habitats of endangered and threatened species in perpetuity,
through voluntary dedication or registration of such lands into the
Illinois Nature Preserves System. The Commission promotes the preservation
of these significant lands and provides leadership in their stewardship,
management and protection.
mission of the Illinois Nature Preserves Commission (INPC) is to assist
private and public landowners in protecting high quality natural areas
and habitats of endangered and threatened species in perpetuity,
through voluntary dedication or registration of such lands into the
Illinois Nature Preserves System. The Commission promotes the preservation
of these significant lands and provides leadership in their stewardship,
management and protection.
Sentinel Nature Preserve, photograph by Dan Kirk
A tapestry of nature's treasures is protected in Illinois by a nationally acclaimed program called the Illinois Nature Preserves System. From the Cache River basin's cypress swamps in southern Illinois to the Illinois Beach dunes along Lake Michigan, many of our state's most rare, natural areas are protected as nature preserves.
These last remaining remnants of our state's natural heritage are almost all that is left of the way the state looked in the early 1800s. Today, less than 0.1% of the landscape remains as it did when first seen by Illinois' early settlers.
Permanently protected by state law, nature preserves are private and public lands that have rare plants, animals, or other unique natural features. Ranging in size from one acre to more than 2,000 acres, nature preserves protect tall grass prairies, oak groves, sandstone bluffs, wetlands, bogs and other threatened natural areas. These lands are the last remnants of the Illinois wilderness, which provides homes for endangered species like the prairie white-fringed orchid, the Prairie Chicken and Illinois Chorus Frog.
Without this protection, many of these exceptional areas would be lost forever. Currently, nature preserves protect over 900 occurrences of endangered and threatened plants and animals. In fact, more than 20% of all Illinois endangered species are in state dedicated nature preserves.
Rapid changes in land use and expanding urban development prompted the Illinois General Assembly to establish the Illinois Nature Preserves Commission in 1963 to create a system of natural areas representative of Illinois' landscape. The Illinois Natural Areas Preservation Act (525 ILCS 30) governs the Commission and charges it to preserve, protect and defend natural areas and endangered species habitat for public benefit.
This commitment to preserve the state's rare natural treasures made Illinois the first state to create such an innovative land protection program. The INPC is now a national model, and more than a dozen states have followed its lead. In 1992, the INPC received international acclaim when it was recognized at the Earth Summit in Rio de Janeiro as an "efficient and effective model of how to provide long-term protection for high quality natural areas."
The Illinois Nature Areas Inventory --completed in 1978 and undergoing a thorough update-- designates the state's most rare nature areas. It serves as a guide for the INPC when determining the eligibility of lands for protection.
Currently there are only 654 high-quality, undisturbed natural communities in the state. Approximately half of these areas are unprotected, and sites are either in danger of being, or have already been, totally or partially destroyed. Each year, 12-15 new nature preserves are dedicated after a thorough and detailed study of an area protecting them into the future.
Many private landowners who have a rare, natural area decide to voluntarily dedicate their property as a nature preserve. Nature preserves landowners:
INPC staff members work with landowners. Staff discuss the importance of the resources on landowners' property, the owners' long term wishes, and the voluntary protection programs available through the INPC. Options available to landowners include nature preserve dedication, land and water reserve registration or enrollment as an Illinois natural heritage landmark.
Nature preserves provide unique opportunities for public enjoyment, critical scientific study and education:
Recreation: Many publicly owned nature preserves are open to the public for hiking and watching nature, including birds, flowers, trees and animals that could face extinction in Illinois if not for the safe haven provided by the nature preserve system.
Research: Each year the INPC issues 400-500 research permits for biologists, scientists, and students to study and monitor rare species of plants and animals. This research can lead to improved ways to protect endangered plants and animals. The nature preserves system serves as a natural storehouse of genetic material, some of which could provide the chemical basis for new drugs and medicines.
Education: While protecting the last few remnants of our state's natural heritage, nature preserves also provide living classrooms to benefit future generations.
INPC stewardship programs are designed to help restore and maintain the natural resources found within the Illinois Nature Preserves, Registered Land and Water Reserves, Natural Heritage Landmarks and other natural areas within the state of Illinois for now and the future.
The INPC actively helps defend nature preserves to ensure these precious areas are not threatened by improper or illegal use.
Every person can help protect nature preserves by respecting these rare treasures and following guidelines that help preserve them for future generations.
Illinois Nature Preserves Commission
One Natural Resources Way
Springfield, IL 62702-1271
Phone: 217-785-8686
updated 12/1/10
Equal opportunity to participate in programs of the Illinois Department of Natural Resources (IDNR), Illinois Nature Preserves Commission, and those funded by the U.S. Fish and Wildlife Service and other agencies is available to all individuals regardless of race, sex, national origin, disability, age, religion, or other non-merit factors. If you believe you have been discriminated against, contact the funding source's civil rights office and/or the Equal Employment Opportunity Officer, IDNR, One Natural Resources Way, Springfield, IL 62702-1271; 217/785-0067; TTY 217/782-9175.


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I have noticed that everyone mounts the trunions on their blanks then sand blasts them and then paints/finish them.
So my question is if the inner part of the blank under the trunions, is not "painted" won't that cause issues down the line with rust, corosion, etc.
Here is a pic form 7.62 X 39 after he demilled a krink. 6th picture down. There is rust after a few years this would cause problems don't you think?


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Be aware that without Javascript, this website may not behave as expected.
June 19, 2015 - MDaemon Security Bulletin - MD061915 - Fix to Content Filter Vulnerability: Recently Alt-N discovered a vulnerability in the content filter of MDaemon that could potentially expose the server to malicious attack. The Alt-N development team has built and tested a patch to correct the potential vulnerability. This security update is rated CRITICAL for affected versions of MDaemon Messaging Server. Visit the Support Bulletin to learn more and download the patch.
Support Bulletin
MDaemon Messaging Server, email server software for Windows, is a trusted alternative to Microsoft Exchange or SBS. MDaemon mail server supports IMAP, SMTP, POP3, and ActiveSync protocols and delivers solid performance from its feature-rich and user-friendly design.
We're excited to announce the release of MDaemon 15. New features include IPv6 support, an improved user interface (UI), improved Account Hijack Detection, email encryption for WorldClient users with Virtru, dynamic screening improvements, and more. In this video, we show you some of the useful features in MDaemon 15. MDaemon Messaging Server is a globally trusted mail server and a solid alternative to Microsoft Exchange or SBS, with prices starting as low as $380.00. Buy now or download a free, fully functional trial to experience its powerful features, easy administration, and low total cost of ownership for your business.
The current version of MDaemon Messaging Server is 15.0.3


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Educational Overview
The Wright Museum's Education and Public Programs Department provides great aesthetic, interpretive and intellectual experiences, and learning opportunities that can inspire and serve diverse audiences for a lifetime. These experiences and opportunities include an array of impacting and enriching curricular and community educational programs, curatorial and library services, a contemporary artists program, volunteer opportunities, and online resources.
Please choose from the following links:
Explore our Educational sites:


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Prevent Blindness America
RP International
Canadian Association of Optometrists
The Canadian National Institute for the Blind
Cecil Textbook of Medicine. 21st ed. WB Saunders Co; 2000.
The Foundation of the American Academy of Ophthalmology.
Retina and Vitreous, Basic and Clinical Science Course. 2001-2002.
Harrison's Principles of Internal Medicine. 14th ed. The McGraw-Hill Companies; 2000.
Ophthalmology. Mosby International Ltd; 1999.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
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Microsoft announces Xbox Music iTunes competitor, coming to PC, Xbox 360, Windows Phone, Android and iOS devices
Microsoft has launched a new music service which it hopes will offer significant competition to Apple's hugely successful iTunes service. The new Microsoft music offering will be called Xbox Music and will debut on its own Windows 8 and Windows Phone 8 devices initially but will also be rolled out for iPhone, iPad and iPod touch a well as certain Android devices too; very soon afterwards. The news comes from Gigaom who managed to speak with Jerry Johnson, general manager of Xbox Music.
But the biggest story to me is that Xbox Music will embrace Android and iOS. Jerry Johnson, general manager of Xbox Music, wasn't able to tell me exactly when the apps for those two platforms are going to come out, but the sense that I took away from the briefing was that his team is working on making it happen sooner rather than later. Xbox Music on Android and iOS will look very much like Xbox Music on Windows Phone 8, which itself in many ways follows the style formerly known as Metro.
So why is this big news? Because Microsoft's past attempts of getting into the music space were much more territorial. The company completely reinvented its DRM for Zune Music, making sure that Zune downloads wouldn't play on anyone's hardware but Microsoft's – a move that irked countless hardware partners who had gotten their devices certified for Microsoft's previous music format.
The Xbox Music service will launch initially on Windows 8, Windows Phone 8 and Xbox 360 only and will come in two flavors. The first will be ad-supported and offered as a free service solely for playback on Windows 8 machines. The premium version will cost $10 a month and will be usable on additional platforms such as the Xbox 360 and Windows Phone 8 phones. Microsoft will also offer a digital download store and a paid cloud music storage service which will supposedly offer an iTunes Match type experience too.
There is no doubt that Microsoft has the power to build something to rival iTunes however past attempts have never been that great. The Zune hardware and software was always hindered by its lack of international availability and it remains to be seen if this service will roll out internationally either. It has often been rumored that Apple would roll out some kind of iTunes subscription service but it has never materialized, maybe this could be the thing to give it a push.
Source: Gigaom
Have something to say about this story? Leave a comment! Need help with something else? Ask in our forums!
Reader comments
Microsoft announces Xbox Music iTunes competitor, coming to PC, Xbox 360, Windows Phone, Android and iOS devices
But... But... Apple has 70 percent of profits in the mobile space!
This is why Microsoft is so ass backwards in everything they do. This is supposed to be a seious competitor to iTunes. Yes it is called XBox Music, why? who decided on that dumb name? If it's a music service why tie it to the XBox name especially when it will be on WP, iOS and the Android platform? A name like iTunes is so universal it hints at it's roots with the "i" you know it's from Apple but it's Tunes which means it handles your tunes and now all your media. So why not call the thing Microsoft Music or Microsoft Median Manager ofcourse those names are ungodly long so you want something shorter, catchier but the point is why put XBox in the name? what does it have to do with anything?
It's actually genius they use the Xbox name in my opinion. Xbox is universal. It has become a media center in the living room of many families. So many families have an Xbox and it was not only till recently I have used it as a media center. The xbox acts as a media center more than a gaming console in my home. It only makes sense to tie anything media to the xbox name.
This builds interest in the xbox name and slowly rebrands it as a media center which will catch the interest of non-gamers.
it's on an xbox. and you may not think xbox is a big name but huge numbers of people worldwide have an xbox, it's got huge brand recognition. i get your point. you want some sort of uniformity but the reality is is names like windows, microsoft, even zune are not "cool" and appealing like xbox is.
i still wonder exactly what this service entails.
Can i upload my own music like google? How much storage? I have mixtape albums so will it have gapless playback? If it has a matching service is it only stuff i bought from microsoft which is useless for my needs like itunes match as i've bought nothing from either? Can i access webfiles on all my devices? Is it streaming radio only like a pandora sort of thing? If there's a software will it just been the zune stuff? Will it be really complicated or bloated? some of the current stuff from microsoft strikes me as really bloated. (apple too actually). Is it sort of like google play where it's an online store to buy all kinds of things like books, movies and music etc?


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HHS falls to South Charleston
HUNTINGTON -- Huntington High has seen success this season by turning up the tempo and turning up the aggressive play on its opposition.
On Tuesday night, the Highlanders (9-3) got a dose of their own medicine, falling 66-46 to a South Charleston (12-1) boys basketball team who forced 24 turnovers to win easily.
"I was surprised at how we played tonight," HHS coach Ron Hess said. "We had been playing pretty good ball the last couple of weeks and playing team basketball. We just weren't aggressive tonight like we were the past few games. I'll take the blame for that. I've got to have us more prepared and ready to play. We just weren't aggressive enough."
South Charleston, the top-ranked team in Class AAA, never trailed in the contest, scoring 10 of the first 12 points and withstanding an early run by Huntington High before using its defense to lead to instant transition offense.
The key run in the contest came near the end of the first half as the Highlanders, ranked seventh in Class AAA, started to establish a little rhythm.
Trailing 20-19, Huntington High's Arick Nicks had a pair of free throws rim out to squash the Highlanders' attempt at a lead.
Instead, the Black Eagles went on an 8-0 run to end the half, highlighted by a 3-pointer just before the buzzer by Devon Harris -- his fourth of the half -- to take a 28-19 lead to the locker room.
The run continued following halftime as South Charleston sensed Huntington High's frustration from turnovers and turned up the pressure.
By the time the dust settled, the once one-point lead from midway in the second quarter had ballooned to a 21-point lead just eight minutes later.
"Even when we beat their press, we wouldn't attack it," Hess said. "We have to attack. We'd have our advantage coming down and we'd wait on them to come trap us again instead of attack them. They (South Charleston) played well and played hard, and we just weren't aggressive."
The turnover problems were two-fold for the Highlanders, who made several mistakes with lazy lob passes over the top or cross-court passes that South Charleston's speedy guards picked off with ease.
Not only did those passes get the Black Eagles into transition quickly, but they also kept the Highlanders from getting into their offense and getting the ball to Nicks in the post.
After keying the Highlanders' early comeback, Nicks fell silent from the middle of the second quarter on because a lack of touches. He finished with nine points and nine rebounds.
"We didn't run hardly any sets tonight," Hess said. "They took us out of our offensive schemes and (kept us) from getting the ball inside. I'm sure that's what they wanted to do. We have to do a better job of handling pressure."
Harris finished the game with five 3-pointers and 20 points to lead South Charleston while Neal Brown added 10 points.
SOUTH CHARLESTON 13 15 19 19 -- 66: Cunningham 8, Harris 20, Dean 2, Moles 7, Williams 4, Brown 10 Kincaid 9, Reese 6.
HUNTINGTON HIGH 12 7 12 15 -- 46: Meadows 7, Nicks 9, Wooding 3, Howard 2, Demoss 8, Tubbs 4, Miller 10, Dunn-Martin 3.


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These are custom embroidered name tape with hook and loop backing. They are approximately 1in. x 5in. and are designed to be attached to your BDU, Helmet, and other Tactical Gear.
Please enter the name for your patch in our COMMENT BOX on the checkout page.
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Embroidered IMPORTANT PLEASE READ: These tapes are custom made-to-order and currently are taking 5-7 business days to produce (we do not produce on Saturdays & Sundays). Please add this to your shipping time and plan accordingly.
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Total number currently on active duty in support of the partial mobilization for the Army National Guard and Army Reserve is 27,965; Naval Reserve, 10,597; Air National Guard and Air Force Reserve, 35,775; Marine Corps Reserve, 4,398; and the Coast Guard Reserve 1,841. This brings the total Reserve and National Guard on active duty to 80,576 from 50 states, the District of Columbia, Puerto Rico and individual augmentees.
At any given time, services may mobilize some units and individuals while demobilizing others, making it is possible for these figures to either increase or decrease.
A cumulative roster of all National Guard and Reserve who are currently on active duty can be found at http://www.defenselink.mil/news/Mar2002/d20020313ngr.pdf.


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This practical changing table allows you to change baby safely with its rounded features and secure front panel. It also offers an open compartment ideal for keeping essential items close at hand, and two drawers equiped with matching wooden handles. You will have everything you need for your little on within an arms reach.Limited 5 year Warranty.
Dimensions: 35.5"L x 19.5"W x 39.25"HShipping Weight: 83lbs.Shipping Note: This item ships directly from the manufacturer within contiguous United States only. Cannot be shipped to AK/HI, PO boxes, US territories, or APO/FPO addresses.


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FORT WAYNE — Churubusco's football team is seeking revenge after a frustrating 34-7 loss last season in the sectional title game.
The Knights come into this year's sectional final game with an uncharacteristic 7-4 record, after only posting two losses from 2010-11.
Luers has had a difficult season, with the hype around the firing of coach Matt Lindsay mid-season due to a scandal involving inappropriate video clips on his computer.
Since Lindsay left the field Sept. 13, the Knights have lost two games, including a forfeit to Wayne High School.
While both teams have very different schedules, the schools have one common opponent — Eastside.
Bishop Luers topped the Blazers last week, 42-7, while Churubusco handed Eastside its only shut-out of the season, 54-0, on Sept. 7.
The Eagles posted four shut-outs in a row to Northeast Corner Conference teams and went undefeated in the NECC to take the conference title.
But the NECC, with two Class 1A teams, three Class 2A and two Class 3A school is no match to Luers' Summit Athletic Conference.
The Knights have faced five Class 5A teams, beat Bishop Dwenger, 58-21, and doesn't have a Class 2A team on their schedule until sectional play.
Luers shut-out Concordia and beat competitive Fort Wayne teams such as Northrop and South Side.
After beating 'Busco last year, the Knights went on to win the state title for the third year in a row.
Game time is 7 p.m. at Bishop Luers Friday.View more articles in:


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Every time your young fan watches the determination of the Man U football players, he is filled with absolute joy. Let him show off his love for Manchester United with this 2013 Home replica jersey from Nike. This tagless soccer jersey features a Manchester team crest applique embroidered on the left chest and team colors for an authentic look. It also features Nike's Dri-FIT performance technology so your young one doesn't break a sweat when he's watching his favorite players tear it up on the field!
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Shop early for holidays and birthdays with our 365 Day No-Hassle Return Policy! Because we stand behind the quality of our products, you can return any item in original condition for up to a full year from the purchase date. We want you and your gift recipients to love what you ordered, but if not, we make returns easy for you.
Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


text: Rainy Season is a subtly, warmed-up, pale gray-beige with a satiny finish. The texture was slightly powder, but it had fairly good color payoff. I didn't have to pack it on to get it to show up on my lid, but it is the kind of the shade that can get lost on lighter complexions. Urban Decay Midnight 15 is more shimmery, as is Urban Decay Verve, which is also darker. Urban Decay Polyester Bride is lighter. MAC Vex has a duochrome, but at certain angles, they are somewhat similar. Giorgio Armani #1 Spring 2012 #4 is more golden and shimmery. Giorgio Armani #19 is more shimmery and warmer. bareMinerals Daydream is more beige. bareMinerals Suspense is darker. See comparison swatches.


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Warm wood floors and white walls bounce natural light across the room.
Modular leather sofas flank a Niels Bendtsen glass coffee table in this sparsely furnished space. Vancouver architect Clinton Cuddington modified a prefab fireplace unit,
removing its faux-brick insert, to create the clean-lined wood-burning fireplace and its twin log storage cubby.
For more inspiration from western Canada, see our Photo Gallery: The Best Of The West.
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She's ready to blow!!! GLA
She's ready to blow!!! GLA
Last edited by midas360; 04-22-2013 at 09:26 AM.
Any buyers of Sirius XM or are you waiting on earnings?
bought our first sat radio from Costco - it's back in their offerings...well, it's XM...but, hey...
might want to go back to the quotes from the book, Midas. -- otherwise, you're doing great!
My app still constantly crashes -- two weeks later
Last edited by denco1; 04-22-2013 at 08:20 PM.


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Hand Vacuums
Why Choose Handy Hand Held Vacuum Cleaners? Handy for cleaning small messes or reaching awkward spaces your bigger vacuum cleaner can't reach, the advantages of hand held vacuums are many. These lightweight cleaners which weigh between 0.7kg to 2.3kg come with attachments such as bendable hoses, soft brushes and crevice tools for enhanced cleaning. Handheld vacuums are ideally suited to clean carpets, upholstery and cars. A great alternative to the larger and heavier vacuums, these handheld vacuums are easy to handle and can be carried around wherever you need to clean with little or no effort at all. Always look out for the suction power, ease of operation, and consider your budget before purchasing a hand held vacuum cleaner online. Note that a more powerful motor may increase the weight of the handheld, so you'll need to balance your power and flexibility needs. Heavier models will tire your hands, especially if you want to use your handheld vacuum for quick clean ups on a daily basis. You also need to know that most hand held vacuum cleaners operate on battery. However, they are cheaper than their bigger counterparts. GoVacuum: Best Source for Handheld Vacuum Cleaners
There's no doubt that handheld vacuums are a great add-on to cleaning system. By cleaning up small areas of dirt and dust effectively, they are able to clean everyday messes with ease. A quick clean up and they are back to their docking station or to be stored away. Their handy uses around the house are many. Now, you can enjoy the convenience of buying these handy cleaning devices online at GoVacuum.com. Bissell, Alessi, Dirt Devil, Eureka, Emer are just some of the brands we stock. We have the widest collection of handheld vacuums and offer free shipping so you can have the product delivered to your doorstep at no extra cost!
Hoover S1156 Sidewinder Hand Vac, Metallic Gold$60.00Sturdy as a belt sander, the Sidewinder Hand Vac is an all-purpose household tool with a cleverly helpful feature--a nozzle that swivels 90 degrees to provide more flexibility in vacuuming hard-to-reach spots. This is helpful in vacuuming out tricky space Learn More
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Can you guess these two famous cousins of mine? Both were named "Benjamin".
Both men grew up within twelve miles of each other, near or in Boston, Massachusetts. They were contemporaries and lived through the American Revolution. One was considered a patriot, and one a traitor.
Both men were scientists, and both invented household items like stoves and forms of central heating. Both were honored by European Scientific Societies. Both developed theories in thermodynamics.
Both men were philanthropists and endowed educational pursuits in America.
Both men had illegitimate children.
Both men were statesmen and politicians. Both were honored in European royal courts. One took a title of nobility, and the other refused to take a title. Both were also considered philosophers.
I don't know if they ever met, and neither was related to the other, but both are my first cousins, one 6 generations removed, the other 8 generations removed.
Cousin #1, Benjamin Thompson AKA Count Rumford
If you have a can of Rumford Baking Powder on your shelf, you have seen his silhouette. He was born in Woburn, Massachusetts on 26 March 1753, the son of Benjamin Thompson and Ruth Simonds. Ruth was the sister to my 5x great grandfather, Caleb Simons (1720 – 1811). At age thirteen he was apprenticed to a Salem merchant, where he learned mathematics and the physical sciences. When the merchant lost his business due to the strained relations between Britain and the colonies, Benjamin Thompson returned home to Woburn to work in a dry goods store. He eventually became a school teacher and took a few classes at Harvard.
In 1772 he served as a British major in a New Hampshire regiment. When the war broke out he sided with the Loyalists. When the British evacuated Boston in March 1776 he fled to England and left his New Hampshire wife behind. He was elected to the Royal Society in 1779. He returned to America briefly during the war and was knighted in 1784. He served the Prince of Bavaria for the next 18 years (the Prince was a relative of King George of England).
He was made a count of the Holy Roman Empire, and took the name "Count Rumford" for his former wife's hometown (Rumford was the former name of Concord, New Hampshire). He was married to the widow of the famous chemist Lavoisier. He wrote the theory that heat was a form of motion, and was the father of thermodynamics. The Rumford fireplace was one of the inventions that changed chimney design forever after making rooms smoke free. He endowed the Rumford chair of science at Harvard and the Rumford Medals of the Royal Society and the American Academy of Arts and Sciences. He is buried in the Auteuil Cemetery in Paris, France.
Cousin #2 Benjamin Franklin
Benjamin Franklin is the better known of the two cousins. He was born on 6 January 1706 on Milk Street in Boston, the son of Josiah Franklin and Abiah Folger. Abiah was the sister of my 7x great grandmother, Bethshua Folger (born about 1650 on the island of Nantucket). Benjamin Franklin was the youngest son of a soapmaker. At age 12 he was apprenticed to his brother James, a printer. At age 17 Benjamin Franklin ran away to Philadelphia to start a new life.
In Philadelphia he became a printer, and started a subscription library in 1731. This library continues today as The Library Company, a research library with rare books and manuscripts. He became a Freemason and entered into a common-law marriage with Deborah Read. He had an illegitimate son, William, who would become the last Loyalist governor of New Jersey.
Franklin became an author, first with Poor Richard's Almanack, and then he became an inventor. He never patented his creations, which included the lightning rod, the Franklin Stove, and bifocal glasses. He became postmaster, and founded the American Philosophical Society. He was awarded the Royal Society's Copley Medal in 1753 and 1756 for his work with electricity. In 1753 he was awarded honorary degrees from both Harvard and Yale.
Politically active, he traveled to London many times as a delegate for Pennsylvania against the Stamp Act. He became a delegate to the Second Continental Congress and a member of the committee that drafted the Declaration of Independence. Following the Revolution he was Ambassador to France and minister to Sweden. In 1787 he was a delegate to the Constitutional Convention.
Benjamin Franklin died 17 April 1790 in Philadelphia and left 1,000 pounds to both Boston and Philadelphia for education to be used 200 years after his death. Philadelphia's portion had grown to more than $2 million and they spent it on scholarships, while Boston's portion grew to almost $5 million which was used to found the Franklin Institute of Boston.
President Franklin Delano Roosevelt stated that Sir Benjamin Thompson ( Count Rumford), Benjamin Franklin and Thomas Jefferson were "the three greatest minds America has produced".
Click here for a previous post on the "Count Rumford House" in Woburn, Massachusetts: http://nutfieldgenealogy.blogspot.com/2012/05/count-rumford-house.html
Click here for a previous post on the "Count Rumford House" in Woburn, Massachusetts: http://nutfieldgenealogy.blogspot.com/2012/05/count-rumford-house.html
Copyright 2012, Heather Wilkinson Rojo


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USDA Seeks Nominees to the United States Potato Board
Release No. 045-14
Hakim Fobia (202) 690-0488
WASHINGTON, Feb. 13, 2014 -- The U.S. Department of Agriculture (USDA) is seeking nominations for the United States Potato Board. The board is composed of producers, importers and a public member, with approximately one-third of the board appointed each year.
Prospective nominees must submit completed applications by July 1, 2014. Appointees will serve a three-year term. Nominations for producer members are submitted by potato producers in various states. Importers nominate importer members while the board nominates the public member. Producer members must produce five or more acres of potatoes to be eligible to serve. The appointees will replace members whose terms expire Feb. 28, 2015, as well as fill currently vacant seats.
Currently, the board is looking to fill 58 open seats for producers and importers from the following states: Alabama, Alaska, Arizona, Arkansas, Colorado, Connecticut, Delaware, Georgia, Hawaii, Idaho, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Michigan, Minnesota, Mississippi, Nebraska, Nevada, New Hampshire, New Jersey, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Tennessee, Utah, Vermont, Virginia, Washington, and Wisconsin.
The board meets regularly to plan promotion, marketing and research activities that benefit the industry. The national program, which became effective in 1971, supports domestic and international marketing and promotion of potatoes.
USDA encourages board membership that reflects the diversity of the individuals served by the research and promotion program. All eligible women, minorities and persons with disabilities are encouraged to seek nomination for a seat on the United States Potato Board.
For more information or a nomination form, please contact Alexandra Imhof, United States Potato Board Industry Communications and Policy Manager, by phone at (303) 369-7783, or by email at: email@example.com. You can also contact Patricia Petrella, AMS Fruit and Vegetable Program Marketing Specialist at (301) 334-2891 or firstname.lastname@example.com.
Visit the United States Potato Boards website at
for more information about the board.
Research and promotion programs are industry-funded, were authorized by Congress and date back to 1966. Since then, Congress has authorized the establishment of 21 research and promotion boards. They empower agricultural industries by establishing a framework for them to pool resources and combine efforts to develop new markets, strengthen existing markets, and conduct important research and promotion activities. The Agricultural Marketing Service (AMS) provides oversight, helping to ensure fiscal responsibility, program efficiency and fair treatment of participating stakeholders.
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Apr 14 2013
A Homemade Year: Winners!
The winners of A Homemade Year are:
3961 Becky Z: "Happy Friday to you!"
2394 Brenda M: "Happy Friday!"
379 Teri: "What a lovely book! I am adding it to my wish list."
2571 Joanne: "Looks like a really cool book!"
5453 Margie U: "Cute book!"
1578 Laura: "Happy Friday! I can't decide between Christmas and Easter either."
298 Mary Ann: "A blessed Friday to you! Beautiful book."
5895 Annalise: "Hello, it's snowing in Michigan! Happy Spring!"
3297 Danag: "Happy happy Friday! I would love to have a copy of this book to read and share with my friends."
707 WendyBrz: "Thank you for the opportunity to enter! This book looks wonderful."
Congratulations, winners! Contact [email protected] to claim your books.
40 Comments and 4 Replies
Bev On Sunday, April 14 at 8:43 pm
Congrats to winners! Maybe next time for me!!!!!
Bea Long On Monday, April 15 at 11:17 am
Congrats to the winners, yep I would love to win anything at least once before I die, haha, but right now my mixer quit and I am beside myself over it. Sure can't afford a new one. I just need a little hand mixer at least…sad sad sad !!!!!
Beth R On Sunday, April 14 at 9:25 pm
I agree; congrats to the winners. I like seeing how many people try to winner. Ree has a very large following!
Beth R On Sunday, April 14 at 9:28 pm
Win, not winner.
Pamela @ Brooklyn Farm Girl On Sunday, April 14 at 10:17 pm
Congrats! Seems like a fun book, I especially liked the craft previews.
Bonnie M On Monday, April 15 at 6:41 am
Congratulations to the winners! What a great way to start the new week!
God Bless.
carah;) On Monday, April 15 at 7:16 am
Congrats to all of the winners!!!!! I ordered this book and plan on using some of the craft ideas with the church youth groups. Have an awesome day:)
Teri On Monday, April 15 at 8:42 am
My heart kind of skipped a beat when I saw the name Teri! Congrats to all the winners! especially you Teri!!!
Teri On Monday, April 15 at 11:32 am
Thanks Teri!
Teri On Wednesday, April 17 at 11:43 am
I think it's me! Thanks Teri! If you're in NY I'll share with you since you have an awesome name!
Michelle F On Monday, April 15 at 8:57 am
This looks like a great book!!!
Teri On Monday, April 15 at 9:13 am
Thank you so much Ree! I look forward to using this book all year! Blessings, Teri
Betty On Monday, April 15 at 9:33 am
What better way to start off the Spring season…..enjoying a new cookbook!
Susan W On Monday, April 15 at 9:36 am
Congrats to you winners! Thank you Ree for another wanderful 'giveaway'
Have a super week everyone!
Deanna On Monday, April 15 at 10:40 am
Happy Monday ?!!
Jennifer R On Monday, April 15 at 10:48 am
Looks fabulous! What a great way to start the week on a rainy Monday in April!!!
Crista On Monday, April 15 at 10:57 am
Congrats to the winners! Better luck to me next time!
Sandra Henderson On Monday, April 15 at 11:17 am
Happy Monday! Love your show and love cookbooks!
Pam Gram On Monday, April 15 at 11:26 am
It's been a long hard weeknd, so starting the week off with the book, your mom and the boys and that amazing Pesto Pasta Salad makes this Monday a great one! Thank you Ree!
Renee Mroz On Monday, April 15 at 11:30 am
yes please!
pam On Monday, April 15 at 11:35 am
Happy Monday and hope for a productive week.
Tisha On Monday, April 15 at 11:59 am
Happy Monday! Wishing the Boston Marathon runners all the best!
Gwen McGill On Monday, April 15 at 12:14 pm
Beth On Monday, April 15 at 12:50 pm
Happy Monday! I have the week off and looking forward to some down time and cooking.
Sharon Maher On Monday, April 15 at 1:27 pm
Happy Monday…….I'm watching the Boston Marathon. Just watching, definitely not running.
Kathy R On Monday, April 15 at 1:43 pm
A good day starts with a positive can do attitude. Here's to a "can-do" week ahead!
lyn On Monday, April 15 at 2:12 pm
Happy Monday
Debby Brown On Monday, April 15 at 2:12 pm
Happy Tax Day Monday!
Susan Pollard On Monday, April 15 at 2:20 pm
Howdy. I would love this book. Thanks for a wonderful show and blog.
Jen On Monday, April 15 at 3:24 pm
Congrats to the winners
Sandy Johnson On Monday, April 15 at 3:41 pm
Happy Monday…praying for those in Boston.
Lindie On Monday, April 15 at 5:50 pm
Happy Tax day! Got mine to the postoffice at 3:30! I'm a procrastinator! I love Daphne on The Chew. Love that whole group! I have a 26 year old that is getting married and she needs this book!
Annika On Monday, April 15 at 7:38 pm
Looks like a lovely book and a GGGG
Victoria H. On Monday, April 15 at 7:52 pm
Happy happy happy Monday! Looks like such a nice book!
Donna O On Monday, April 15 at 10:15 pm
Congratulations to the winners!
Maggie Bensuaski On Monday, April 15 at 11:20 pm
Your blog is new to me this year and is such a treat to look forward to ~ thank you! I usually just check out the front recipe page, but today also clicked on "Home and Garden" and look what I found ~ what fun!
Alice On Tuesday, April 16 at 2:35 pm
Congratulations to the winners, enjoy!
Didi P On Thursday, April 18 at 3:10 pm
Congrats…. I went and bought the book … ~smile~
It just seem like such a fun read and give Idea's through out the year ~
Can't wait to get it in the mail ~
Jessica K On Friday, April 19 at 5:10 pm
Oh I am so sad I missed this one. I hadn't logged on in a few dys. I have been searching for books to make family life more meaningful…darn
Cookie On Tuesday, April 23 at 2:02 pm
Avocadas- about a 100!!!
Peggy Hazard On Tuesday, April 23 at 2:40 pm
Love avacados. Definetly a 10.
Ernie On Tuesday, April 23 at 3:01 pm
Love avacados so much I'm building my garage around the tree!
Andrea On Tuesday, April 23 at 4:46 pm
On a scale of 1 to 10, about 450. Favorite midnight snack: Get a slice whole wheat toast, smash some avocado on there, and sprinkle with salt. Deeeelish!
Carla On Wednesday, April 24 at 11:11 pm
About a 6 on my all time favorites list.


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Cubic Zirconia Tribal Stud Earrings 3 3
A Wardrobe Staple Since buying these earrings a couple of months ago, I have found myself wearing them to work at least once a week. They pair beautifully with statement necklaces. These have become a definite wardrobe/accessory staple for me. You simply can't beat the price. They look so much more expensive than they are. May 18, 2013
For $5 these are perfect! Love these earrings. I wear them to work pretty much everyday - the look great with everything and are fine quality for the money. March 15, 2013
Poorly made...one defective earring Very disappointed. This is the first product from World Market that has disappointed me. One of the earrings was defective, but probably not worth the cost to sent them back. October 13, 2013
1-3 of 3


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- Finanzplanung (1)
- Geschichte 1995-1998 (1)
- Haushal (1)
- Sicherheit (1)
- Sparen (1)
- buffer-stock models of saving (1)
- business owners wealth (1)
- entrepreneurship (1)
- household wealth (1)
- income risk (1)
- Disentangling the importance of the precautionary saving motive (2005)
- We evaluate the importance of the precautionary saving motive by relying on a direct question about precautionary wealth from the 1995 and 1998 waves of the Survey of Consumer Finances. In this survey, a new question has been designed to elicit the amount of desired precautionary wealth. This allows us to assess the amount of precautionary accumulation and to overcome many of the problems of previous works on this topic. We find that a precautionary saving motive exists and affects virtually every type of household. However, precautionary savings account for only 8 percent of total wealth holdings. Even though this motive does not give rise to large amounts of wealth, particularly for young and middle-age households, it is particularly important for two groups: older households and business owners. Overall, we provide strong evidence that we need to take the precautionary saving motive into account when modeling saving behavior. Klassifizierung: D91, E21, C21
- Precautionary savings and the importance of business owners (2006)
- In this paper, we show the pivotal role business owners play in estimating the importance of the precautionary saving motive. The fact that business owners hold higher-than-average wealth while facing higher income risk than other households leads to a correlation between wealth and labor income risk regardless of whether or not a precautionary motive is important. Using data from the Panel Study of Income Dynamics in the 1980s and the 1990s, we show that within separate samples of both business owners and non-business owners the size of precautionary savings with respect to labor income risk is modest and accounts for less than ten percent of total household wealth. However, pooling together these two groups leads to an artificially high estimate of the importance of precautionary savings. Data from the Survey of Consumer Finances further confirms that precautionary savings account for less than ten percent of total wealth for both business owners and non-business owners. Thus, while a precautionary saving motive exists and affects all households, it does not give rise to high amounts of wealth in the economy, particularly among those households who face the most volatile labor earnings. Klassifizierung: D91


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Call Us Toll-Free @ 866-539-4278866-539-4278
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Finding activities that keep your toddler busy for more than a couple minutes can be difficult, but peg puzzles are a great way to keep those little hands occupied while learning shapes, colors, letters and numbers, animals and even geography.
Use the filters to the left or simply scroll down to begin viewing all pages.
Free shipping and flat rate offers for US only but excludes HI and AK.
Need to return or exchange a puzzle? It's easy. Simply call us at 866-539-4278 or email firstname.lastname@example.com to request a Return Authorization Number, and we will send you a prepaid return label for the item.
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Puzzle Warehouse recycles everything it can to save the environment and to keep costs and prices low.


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Collection: Human Rights Documentation Initiative
Description: In English. Amazon Watch is an NGO founded in 1996 to protect the rainforest and advance the rights of indigenous peoples in the Amazon Basin by running various environmental and indigenous rights campaigns. The site contains news, blog posts, and annual reports.
Captured 3 times between Jul 19, 2012 and Jan 18, 2013
Videos: 17 Videos Captured
Subject: economic, social, and cultural rights--social and cultural rights--indigenous populations, economic, social, and cultural rights--social and cultural rights--ethnic identity, economic, social, and cultural rights--environment, laws, justice, and judicial proceedings--land rights
Creator: Amazon Watch
Publisher: Amazon Watch
Source: http://amazonwatch.org/
Language: English
Coverage: South America--Brazil; South America--Colombia; South America--Ecuador; South America--Peru , Latin America
Identifier: http://wayback.archive-it.org/1475/*/http://amazonwatch.org/
Collector: UT Libraries
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Partly Cloudy
Wind: 3 mph
To The Editor:
We (Mary Ina Goodyear Peterson and Pastor David Peterson) are moving to Maine and are inviting everyone to our going away party-open house on June 22 between 1 and 5 p.m. at the American Legion on Stowe Street in Waterbury. There will be light refreshments. Come as you are and please drop by for some fun and fellowship; hugs and kisses are optional. This is your chance to say goodbye to Mary and David and this is our chance to say goodbye to all our neighbors and friends. The U-Haul will be packed, gassed up and ready to go north-northeast come 5 p.m., June 22. Come and wave goodbye!
David Peterson and Mary Goodyear


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|Meiler Lab
Computational Chemical and Structural Biology
About Meiler Lab
Research in our laboratory seeks to fuse computational and experimental efforts to investigate proteins, the fundamental molecules of biology, and their interactions with small molecule substrates, therapeutics, or probes. We develop computational methods with three major ambitions in mind.
A) To enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses;
B) Design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways.
C) Understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs.
Crucial for our success is the experimental validation of our computational approaches which we pursue in our laboratory or in collaboration with other scientists.
Current research applications focus on new approaches to a) drug and probe development for neurodegenerative disorders and diseases including Schizophrenia, Alzheimer's, and Parkinson's, b) understanding the structural determinants of antidepressant binding to neurotransmitter transporters, c) cardiac arrhythmia as caused by the complex interplay of potassium channel regulation and drug interactions, d) multidrug resistance in cancer and bacterial cells related to multidrug transporter proteins, and e) structural basis of viral infections and antibody activity.
Chemistry summer student Don Davis was awarded a Warren Fellowship for this summer. Congratulations, Don!
The grant typically supports students for 2 years. Congraulations, Michaela!
Cristina was a visiting student in the Meiler lab. Congratulations, Crisitina!
Congratulations to Mariusz, Liz, Sten, and Elizabeth!
Congratulations, Dr. DeLuca!
Congratulations, Alyssa!
Jeff and Bian presented on "Prediction of KCNQ1 Mutations Associated with Long-QT Syndrome." Congratulations!!
Elizabeth's undergraduate honors thesis was entitled " Structural Studies on Growth Hormone Secretagogue 1a and Ghrelin Interactions." Congratulations, Elizabeth!
Jonas was competing in the 0-9 age group. Congratulations, Jonas!!
Congratulations, Sevy!
Meiler laboratory graduate accepted a 2-year lecturer position at Rollins College in Orlando, Florida. Congratulations, Kelli!
The fellowship includes a 3-year stipend. Congratulations, Alex!
Meiler laboratory graduate accepted an assistant professorship position in the Chemistry Department at The Ohio State University in Columbus, Ohio. Congratulations, Steffen!
Great job, Brittany! See the post here: http://nationalsciencefoundation.tumblr.com/post/112625916214/inspired-by-role-models
Congratulations, John!
Congratulations, Darwin!
Rocco Moretti presented workshop materials to 60 participants!
The meeting took place on March 4-8 at Lake Tahoe and had 160 participants
Sten Heinze successfully defended his dissertation entitled "Improvements for BCL::Fold de novo protein structure prediction".
Dr. Meiler was one of fifteen faculty members selected for the Chancellor Faculty Fellows Program. This competitive program recognizes and supports outstanding young scholars from a diverse set of disciplines across Vanderbilt's campus. (http://www.vanderbilt.edu/provost/initiatives/chancellors-fellows-program/) Congratulations, Jens!
Alyssa passed phase II of her qualifying exam in the Neuroscience department. Congratulations!
Congratulations, Bian!
Alex received this award for his poster presentation at the ACS meeting in San Francisco. Congratulations, Alex!
Stephanie Hirst DeLuca successfully defended her dissertation entitled "Protein Structure Elucidation by Combining Computational and Experimental Methods"
Published in JBC! Read all about it here: http://www.jbc.org/content/early/2014/07/18/jbc.M114.572875
Darwin Fu won an informatics graduate student fellowship from the Phrma foundation. Congratulations, Darwin!
The Meiler Laboratory is one of several laboratories that have been awarded a University Central Discovery Grant for the proposal entitled "An Intel Xeon Phi Coprocessor (IXP-CPU) Computing Cluster for ACCRE". Congratulations!
Congratulations, Alex!
The Ligand Docking ROSIE app is now available! Please visit: http://rosie.rosettacommons.org/ligand_docking
Mariusz Butkiewicz successfully defended his dissertation entitled: Advancing Quantitative Structure Activity Relationship Strategies in ligand-based Computer-Aided Drug Design.
Jordan Willis successfully defended his dissertation entitled: Rational Antibody Design: From Mechanisms of Binding to Novel Vaccine Strategies.
Yan constructed a full length model of Metabotropic Glutamate Receptor 1 and docked a focused library of ligands according to their Structure-Activity Relation.
Whether you are a Rosetta newcomer or an advanced user, you are invited to take part in our 2014 Rosetta workshop, April 28 - May 1, to learn how Rosetta can be used for protein modeling, with an emphasis of membrane proteins. Details and Registration Information Tutorials from the 2011 workshop
After learning about using Rosetta to model membrane proteins, stick around to learn more about them at the Vanderbilt Center for Structural Biology conference entitled Biomolecular Structure, Dynamics, and Function: Membrane Proteins!
The Vanderbilt Center for Structural Biology is hosting the Biomolecular Structure, Dynamics, and Function: Membrane Proteins Symposium from May 2-4, 2014. The Early Registration deadline is March 1, 2014! Details and Registration Information
The BioChemical Library (BCL) version 3.1 is now released for Linux, Windows, and Apple and is available for download on meilerlab.org. This release features a new single user academic license, which is now distributed via a webserver on the meilerlab.org website. The new licensing systems enables users at academic and other non-profit institutions to receive a license file within seconds, along with an email detailing how to use it and install the BCL.
This release also includes a number of bug fixes and enhancements, as well as a new application (protein:FusionProtein) for working with chimeric proteins. Brief summaries of all released BCL applications are available on the bclcommons webpage.
Friends and collaborators outside the lab can download the newest release from meilerlab.org and use it with a license file obtained from http://www.meilerlab.org/servers/bcl-academic-license
Congratulations to Daniel!
The VICB award recognizes high-impact research by Vanderbilt researchers. This publication is one of only 6 in the department with a sufficiently high impact (45 citations in total) for the 2014 awards.
Congrats Yan and Jessica!
Dr. Edward W. Lowe, Jr. received a second high performance GPU hardware award from NVIDIA for his work in accelerating algorithms important in biology and chemistry using multiple GPUs. Congrats Will!
Steven McIntyre, an undergraduate student advised by Axel Fischer in the Meiler laboratory, was selected as one of the first recipients of the Littlejohn fellowship. The fellowship encourages undergraduates to participate in research and scholarship across the humanities, natural sciences, and social sciences. Congats Steven!
Drs. Annette Beck-Sickinger and Torsten Schoeneberg from Leipzig University and Jens Meiler from Vanderbilt University receive a grant "Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions" that is jointly funded by the National Science Foundation (NSF) and the Deutsche Forschungsgemeinschaft (DFG). The grant will develop a novel docking algorithm that leverages Structure-Activity-Relations (SAR) and apply this algorithm to understand regulation of G-Protein Coupled Receptors (GPCRs).
Steven Combs successfully defended his dissertation entitled "Identification and Scoring of Partial Covalent Interactions in Proteins and Protein Ligand Complexes." Congrats Steven!
The BioChemical Library version 3.0 is available for download on meilerlab.org. This release features our suite of cheminformatics and QSAR applications, along with new and improved extensions to bioinformatics applications, including JUFO9D, membrane-folding protocols, and SAXS simulation.
User-interface improvements include a friendlier command line interface that offers suggestions whenever options are mistyped, and earier to read help dialogues (and many more of them!),
Download the newest release from the bcl downloads page.
Congratulations Darwin!
Stephanie is one of only 30 recipients of this year's National Federation of the Blind Fellowship, for which there were over 700 applicants. Congratulations Stephanie!
Tyler Gilcrest, a VU undergraduate researcher in the Meiler Lab, graduated with honors from the Vanderbilt chemistry program. Tyler's performance earned him the Thomas W. Martin award for excelling in physical chemistry. Excellent job Tyler!
The 3 Minute Thesis competition sponsored by the Vanderbilt Graduate Student Council challenged graduate students in all fields across campus to present their thesis in only 3 minutes to a diverse audience. Students were challenged to present their research topic, explain how the research is conducted, and identify what impact it will have on the general or academic community. Elizabeth Nguyen, a graduate student in the Meiler Lab, received a co-first place prize for her presentation on "Progress Towards Unlocking the Treatment for Cognitive Impairment". Her research involves the computational modeling of G-protein coupled receptors, specifically metabatropic glutamate receptor 5 and its binding site for drugs used to treat schizophrenia and Fragile X Syndrome.
Amanda's stipend will allow her to explore computational design of membrane protein ligand interactions. Congratulations to Amanda!
Stephanie will be giving a talk on RosettaEPR at the 2013 Biophysics conference in South Korea, May 22, at 10:15-10:30 AM
The Meiler lab receives an ORAU/ORNL High Performance Computing (HPC) Grant: "Investigation of the Mechanism of Cellulose Synthesis in Plants Using Neutron Scattering and High Performance Computing"
Dr. Lemmon received a fellowship from Emerging Leaders in Biosecurity Initiative to facilitate meeting with leaders in Biosecurity.
Whether you are a Rosetta newcomer or an advanced user, you are invited to take part in our 2012 Rosetta workshop, Nov 13-16, to learn how Rosetta can be used for protein structure prediction. Details and Registration Information Tutorials from the 2011 workshop
Faculty of 1000, a large group of researchers in the fields of biology and medicine that identify the most relevant research in the field, has recommend EM-fold: de novo atomic-detail protein structure determination from medium-resolution density maps., Structure, 2012
Congrats Brian!
The BCL CASP team (Sten Heinze, Daniel Putnam, and Pedro Teixeira) have been awarded an attendance fellowship to defray the costs of attending the CASP conference. Congrats to the BCL CASP team!
Dr. Edward W. Lowe, Jr. received a high performance GPU hardware donation from NVIDIA for his work in accelerating algorithms important in biology and chemistry. Congrats Will!
The annual Vanderbilt Institute for Chemical Biology proved especially rewarding this year, with two winners from Meiler Lab. Daniel Putnam won an Ipad through a raffle. Mariusz Butkiewicz co-authored a poster together with Rebecca Sandlin from the David Wright laboratory "Finding the Pathway: New Machine Learning Paradigms for the Identification of Lead Compound Targets from Phenotypic Antimalarial Assays" that won a poster prize. Congratulations!
Congrats Daniel!
The Meiler lab was awarded a grant "Computational Design of Protein-Ligand Interfaces - a Therapeutic Strategy" from the NIH National Institute of General Medical Sciences (NIGMS). The grant will create advanced methodology to computationally design and experimentally verify protein-ligand interfaces. It will further explore use of these methods to create protein therapeutics for treatment of prostate cancer, bacterial infection, and cocaine overdosing.
Gordon Lemmon, Steven Combs, Jordan Willis, and Sam DeLuca presented research talks at the Rosetta conference. The topics include: "Refactoring Rosetta for Chemistry", " Knowledge-Based Potentials for Partial Covalent Interactions", "Anti-HIV antibody design using Rosetta", and "RosettaQSAR - protein-ligand docking guided by pharmacophore maps"
The Meiler laboratory was awarded a grant "Ligand-Macromolecule Recognition: A Collaboration in Research and Education Between Vanderbilt and Leipzig University" from the NSF Office of International Science and Engineering (OISE). It is the objective of this proposal to develop a sustainable collaboration in education and research between Vanderbilt and Leipzig Universities in the area of chemical biology.
Congrats to Steffen, who received a postdoctoral fellowship from the American Heart Association
The topics were Bcl::ChemInfo Suite Enables Machine Learning-Based Drug Discovery Using GPUs, and GPGPU Accelerated Protein Similarity Measures Identifying Biologically Relevant Structure.
Dr. Nathan Alexander successfully defended his dissertation: Protein structure elucidation from computational techniques and sparse EPR data
Daniel's research will be on the topic of Small Angle X-ray Scattering (SAXS) Restraints to Promote de Novo Protein Structure Prediction
Dr. Julia Koehler successfully defended her dissertation: Method development for membrane protein structure determination using NMR spectroscopy and computational techniques
The awards provide financial support for presenting their research at the Computational Biophysics to Systems Biology (CBSB12) symposium.
Stephanie Hirst receives the prestigious Ruth L. Kirschstein National Research Service Award (NRSA) from NIH for her project "Investigating the Role of Substrate Binding in LeuT Transport With RosettaEPR." Congrats Stephanie!
The Meiler laboratory receives a Research Experiences for Undergraduates (REU) grant from NSF for research related to the CAREER award: "Cryo-EM guided de novo Protein Fold Elucidation"
The Meiler laboratory receives a pilot project grant from the Vanderbilt Diabetes Research and Training Center (DRTC) "Exploring Allosteric Modulators of Neuropeptide Y4 Receptor"
Brittany presented her research plan entitled "Computational Design of Protein-Ligand Interfaces in (beta/alpha)8 Barrels for Applications in Protein Therapeutics"
Jordan Willis was invited to give an oral presentation at the Keystone Symposia on HIV Vaccines
Brittany Allison, a chemistry student in the Meiler laboratory, received a prestigious National Science Foundation (NSF) Graduate Research Fellowship. Brittany works on computationally engineering proteins that bind small molecules. Her research has implications for understanding the fundamentals of protein-ligand interaction, engineering enzymes, and protein therapeutics. Brittany will start her fellowship after completing her training on the Chemical Biology Training Program, an NIH-funded initiative of Vanderbilt's Institute for Chemical Biology and the Chemistry Department.
Sandeep presented his research plan entitled "Enhancement of drug discovery tools through knowledge based conformational sampling and chemical shift predictions"
Daniel Putnam's AMIA paper - "Exploring Schizophrenia Drug-Gene Interactions Through Molecular Network and Pathway Modeling", has been accepted as one of the eight finalists in the Student Paper Competition at the American Medical Informatics Association conference in October. Update 10/28/2011: Daniel was awarded 2nd place at the conference, congratulations, Daniel!
Nils Woetzel successfully defended his thesis, "A novel approach to de novo protein structure prediction using knowledge based energy functions and experimental restraints."
Zollie White, an undergrad from Morehouse College, spent the summer of 2011 researching with Will Lowe in the Meiler Lab through the Vanderbilt REU program. He presented this research at the 2011 Herty Medalist Undergraduate Research Symposium held at Morehouse College was awarded the top prize. For this, he received a one-year membership to the American Chemical Society (ACS) and a $500 travel award to a national ACS conference. Congrats, Zollie!
Congrations to Mert Karakas for having successfully defended his thesis "BCL::Fold-De novo Protein Structure Prediction by Assembly of Secondary Structure Elements"
Will Lowe received an NSF fellowship for his project "PROPMAP: A Novel GPU-accelerated Structure-Property Relationship Mapping Algorithm Utilizing Volunteer Computing." The prestigious award supports Dr. Lowe's research for three years in the Meiler Lab. Congrats, Will!
Liz Dong of the Jens Meiler lab at Vanderbilt recently received a short term research grant to study at the Univeristy of Leipzig in Leipzig, Germany. She will spend one month this fall developing a computational method that will allow for the binding pose of a drug within a receptor to be determined. Her method will be guided by experimental data collected on drugs that bind G-protein coupled receptors, working with the lab of Torsten Schöneberg. Congrats, Liz!
Mariusz passed his qualifying exam with his proposal: Comprehensive protein-ligand interaction mapping through quantitative structure activity relationships. Congratulations Mariusz!
Congratulations Zach!
Kelli's was awarded an NIH NRSA doctoral fellowship to investigate "Conformational Changes Underlying Intracellular Gating of the Leucine
Transporter." Congratulations Kelli!
Sten passed his qualifying exam with his proposal: A novel approach
to de novo protein structure prediction using multiple partial templates. Congratulations Sten!
Ralf successfully defended his thesis, Machine Learning Algorithms for Prediction of Biological Activity and Chemical Properties, earning his PhD, Congratulations Ralf!
Dr. Jens Meiler was promoted to Associate Professor with tenure.
Congratulations to Andrew Morin on successfully defending his PhD thesis on April 26, 2011. The thesis was presented on "The Computaional Design of Protein Ligand Interfaces".
Steven Combs has successfully passed his qualifying exam on April 23, 2011 and proposed his research on "Thermostabilization of industrially relevant proteins through computational design of partial covalent interactions".
Meiler Laboratory has been awarded Vanderbilt University Discovery Grant for research on "De novo Design of Large protein".
Liz Dong has won best oral presentation prize at Chemical & Physical Biology retreat at Nashville Zoo on April 18, 2011. She gave her oral presentation on "Structural studies of the interaction between mDlu5 and allosteric modulator". Congratulations to Liz !!!
Julia Koehler won a travel grant to attend the Gordon Research Conference "Computational Aspects - Biomolecular NMR" in May 2011 and will present her work on " De novo membrane protein folding from sparse NMR data ". Congratulations!!!
Brittany Allison, a graduate student at Meiler Lab has successfully passed her Priliminary Qualification Exam on April 6, 2011.
Louesa Akin is a undergraduate student attending Centre College in Kentucky who pursues research in the Meiler laboratory focused on Membrane Protein Structure Prediction using sparse NMR restraints. She was selected to receive the Goldwater Scholarship for undergraduate students. Louesa participated in the Summer Science Academy program in summer 2010 and will participate in the Research Experience for Undergraduates in chemical biology in summer 2011.
Liz Dong is a MD/PhD student in the second year of her graduate studies. She won the prestigious PhRMA-Paul Calabresi Medical Student Research Fellowship. The fellowship is offered to medical students who have substantial interests in research and teaching careers in pharmacology - clinical pharmacology. Liz works on new technologies in the Meiler laboratory to develop allosteric modulators of metabotropic glutamate receptors, important targets for many neurological diseases.
David Nannemann will be defending his Doctoral research on "Directed Biosynthesis of the Nucleoside Analog Drug Didanosine", at the Stevenson Center, Room 5502, 2:00 pm.
Stephanie Hirst unconditionally passed her Qualifying Exam on February 3, 2011 and the proposal was called "Structural Elucidation of the Role of Na+ and Leucine Binding in the LeuT Transport Mechanism using ROSETTAEPR". Congratulations to Stephanie!!!
Steffen presented his doctoral research dissertation "CryoEM guided de-novo protein folding" on November 22nd, 2010. His thesis committee approved his presentation and accepted his research, making him the first to complete the Chemical and Physical Biology PhD Program. Congratulations, Steffen!!
Steffen Lindert will give a presentation at the Pacific Symposium on Biocomputing in January on Hawaii (about EM-Fold and our results participating in the cryoEM modeling challenge). He received an NIH travel award to cover the costs associated with the conference.
Congratulations to Liz Dong, an MD/PhD student in the Meiler lab, on her successful completion of qualifying exams on 9/2/2010
Congratulations to Meiler Lab members Kristian W. Kaufmann, Gordon H. Lemmon, Samuel L. DeLuca, and CSB outreach coordinator, Jonathan H. Sheehan! Their recent publication, "Practically Useful: What the Rosetta Protein Modeling Suite Can Do for You" made the list of the TOP 20 most downloaded articles from the journal Biochemistry.