text:
Highlighted price = Cheapest round-trip flights
Prices are round trip per person (conditions apply)
Fredericton and St Thomas airports and terminals
Airports in Fredericton NB, CA
Fredericton Airport (YFC)
Distance from City Center: 6.3 miles
Airports in St Thomas , VI
Cyril E King (STT)
Distance from City Center: 2.6 miles
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Flights to St. Thomas
Fredericton International Airport
Orbtiz.com makes finding flights from Fredericton to any domestic or international destination easy. The website searches different flight combinations to find airline tickets with low fares. The Fredericton International Airport is located in Lincoln, approximately eight miles southeast of Fredericton, the capital of New Brunswick. It's the busiest airport in the province and serves over 200,000 passengers each year. Three airlines service the airport: Air Canada, Sunwing Airlines and Air Transat.
Parking and Transportation
If you need to leave your car at the airport while you travel, the airport has a long-term parking lot with 360 available spaces. The cost to use the parking lot is $10 per day for the first three days, and $5 per day after that. You can also take a taxi from Fredericton. Checker Cab provides the primary taxi service in the area, and fares cost between $16 and $26, depending on your pickup point.
Dining at the Airport
If you want to have a meal before you board your plane, the airport has a restaurant open from 5:00 a.m. to 8:30 p.m. There is also a concession kiosk located in the departure lounge, which is open from 4:30 a.m. to 1:00 p.m. When you use Orbitz.com to find flights from Fredericton, the website handles all of your travel arrangements. This way, you have plenty of time to grab a bite to eat before your flight.
Airports in St. Thomas
If you are looking to book cheap flights to St. Thomas, check out Orbitz.com. The Cyril E. King Airport provides domestic and international service to the island. It is the busiest airport in the Virgin Islands and is located two miles west of the business district of Charlotte Amalie on the island of St. Thomas. The airport has one main runway and 11 gates.
Transportation From the Airport
There are car rental companies available on the island of St. Thomas. Remember, cars drive on the left in. Check to see if your hotel or resort offers a shuttle from the airport. The island has many taxis of various sizes, from compact cars to large, covered trucks. They generally charge $1 per ride, and they are usually the cheapest way to navigate the island. Orbitz.com is a complete trip planner, from flights to car rentals. When you're checking out flights to St. Thomas, you can check the prices of budget car rentals, too.
Weather in St. Thomas
St. Thomas has a tropical climate. The average temperature is in the 80s all year. It does not have a rainy season, although there are fluctuations in rainfall from month to month. Remember to bring your bathing suit if you plan to visit the beaches.
St. Thomas's Major Attractions
St. Thomas is known for its beautiful beaches. It also is home to Blackbeard's Castle and a wildlife retreat. It has a golf course, shopping, sailing and snorkeling. Orbitz.com can help you find budget flights to St. Thomas for your next vacation.
More to explore for Fredericton to St Thomas
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text:
Design by Marmel Paper
Drive part-time, full-time, or anytime with Uber!
Design by Marmel Paper
Just designed a new all-black Stranahan's bottle for their new Diamond Peak whiskey. It's pretty good stuff.
The particular Italian know-how that mixes design and handcraft brings packaging to a new level of perfection.
The Re/Labld press-kit has been designed to enhance the feeling of Immortal Fashion. The simple lines, the straight edges – a masterful craft technique – and the black dress make of this box an unique piece, as glamourous as the items exchanged at relabld.com. The essential shape, carved to perfection and covered in Ispira™ paper by Fedrigoni™, reveals itself upon opening, when a four-leafed flower blossoms and the full press-kit is revealed. Inside, a brochure, a look-book and a charity folder recount the tale of the groundbreaking experience you can live at Re/Labld.
In three words, the Real Italian Design.
All, built piece by piece with the best materials and in the quintessential elegance of our worldfamous handcraft skills.
I lined the basket with a piece of wax paper just to make sure the buttery cookies don't leave grease marks, then tied it up with ribbon so the cookies look as fantastic as they taste.
Once you have your basket put together, you can stack the cookies in next to each other like this:
Or in a one long row like this:
Either way, eight cookies fit perfectly.
Gillemore - Magical Gin Branding & Packaging by Skinn
"Louis Gillemon, a 19 years young entrepreneur asked us to develop a new brand of 'Premium Gin'. Despite his young age, he has already accumulated lots of knowledge. With passion and a nose for business he created his 'magical' gin. We developed with Louis for Gillemore a visual concept with a content, mixing design, premium gin and lots of brand experience."
Skinn is a creative consultancy with specialist skills in graphic design, branding, art direction and website design. From brochure creation to a complete re-brand they provide visual solutions that communicate the unique values and messages of their clients. Their grounding in design and love of typography drives them to bring out the best creative response for each project.
Concept for a deluxe yo-yo inspired by macarons, by Weston Doty
Cookies from 50 Delicious Desserts, 1938. National Biscuit Company. Via Eudaemonius / flickr
RM Rum packaging by Alexey Malina Studio
"RM is a blend of several rums of the Caribbean which undergoes it's final ageing in the North of Italy in three different casks: acacia, Swiss oak, and, finally, cherry. The unusual cask strength of 56,8% is achieved by presence of an overproof rum. In the packaging design we tried to reflect the author's approach and unusual strength of rum. For this purpose we used a symbol of a bomb in the title which also helped us to reflect the name of the drink, and placed a dictionary article with author's definition of rum. Each bottle is limited edition and signed by the author."
Design studio Alexey Malina provides services in branding and digital communication. They are based in Moscow, Russia and cooperate with clients all over the world creating unique brand experiences for companies and products.

subset: commoncrawl


text:
70 Reviews
Great recipe. Easy to make. Used recipe for a tailgate party and had enough to bring to work. There will be no left overs for this recipe!!
I only let myself make this once a year because I will eat it all. I melt the stuff in the microwave in a big plastic bowl and then mix in the cereal and then dump the powdered sugar on top. I then seal the lid really good and shake and roll the bowl around. It works really well to mix in the powdered sugar. This is awesome addicting stuff but a little messy. Enjoy! Merry Christmas.
This recipe uses double the coating ingredients of most of the other recipes online, and just slightly more cereal. A 12.8 oz. box of rice chex has 13 cups. Recipes with 1/2c peanut butter and 1 c chocolate chips call for 9-10 cups of cereal. I didn't measure the cereal before making the recipe, assuming it would be doubled too, 18-20 cups, and I ended up with not enough puppy chow. I thought the coating was very thick. Next time I'll use more cereal.
I've tried many different puppy chow
i tried this at a church function and it was the most delicious thing i had ever tried. My friend would bring me some whenever she made it and i am so happy to have the recipe. thanks :)
couldn't find this recipe in my old cookbooks, this one is just the same! thanks!!
Sweet but awesome.
Just made this in matter of minutes to take to work tomorrow for our Christmas snack day. Just as I remembered as a child. YUMMY- Thanks for posting it.
This is a classic snack mix and tastes great. Please be aware that despite the title and the suggestion to serve in a doggie dish, this is a snack meant only for people, not pets (chocolate is toxic to dogs). I use several flavors of Chex cereal in this instead of Crispix.


text:
Sapphire Radeon HD 7790 2GB OC Edition Video Card Review - Benchmarks - Hitman Absolution
Hitman Absolution
Version and / or Patch Used: Latest Steam Update
Timedemo or Level Used: Built-in Benchmark
Developer Homepage: http://www.ioi.dk/
Product Homepage: http://hitman.com/
Hitman: Absolution is an action-adventure stealth game developed by I/O Interactive and published by Square Enix. It is the fifth entry in the Hitman game series, and runs on I/O Interactive's proprietary Glacier 2 game engine. Before release, the developers stated that Absolution would be easier to play and more accessible, while still retaining hardcore aspects of the franchise. The game was released on 20 November 2012, which is in the 47th week of the year (in reference to the protagonist, Agent 47).
Checking out one of our newer games you can see that Hitman Absolution shows no difference between the cards.
PRICING: You can find products similar to this one for sale below.
United States: Find other tech and computer products like this over at Amazon's website.
United Kingdom: Find other tech and computer products like this over at Amazon UK's website.
Australia: Find other tech and computer products like this over at PLE Computer's website.
Canada: Find other tech and computer products like this over at Amazon Canada's website.
- Page 1 [Introduction and Package]
- Page 2 [The Card and Specifications]
- Page 3 [Benchmarks - Test System Setup]
- Page 4 [Benchmarks - 3DMark 11]
- Page 5 [Benchmarks - Unigine Heaven Benchmark]
- Page 6 [Benchmarks - Phantasy Star Online 2]
- Page 7 [Benchmarks - Lost Planet 2]
- Page 8 [Benchmarks - Just Cause 2]
- Page 9 [Benchmarks - F1 2012]
- Page 10 [Benchmarks - Metro 2033]
- Page 11 [Benchmarks - Dirt Showdown]
- Page 12 [Benchmarks - Nexuiz]
- Page 13 [Benchmarks - Sniper Elite V2]
- Page 14 [Benchmarks - Sleeping Dogs]
- Page 15 [Benchmarks - Far Cry 2]
- Page 16 [Benchmarks - Hitman Absolution]
- Page 17 [Benchmarks - Tomb Raider]
- Page 18 [Benchmarks - BioShock Infinite]
- Page 19 [Benchmarks - High Quality AA and AF]
- Page 20 [Temperature Test]
- Page 21 [Sound Test]
- Page 22 [Power Consumption Test]
- Page 23 [Pricing, Availability and Final Thoughts]
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Join Date: Aug 2006
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Rachelle, mommy to 8 year old boys!
My Blog-free homeschooling finds and my lesson plans and link to the new User Agreement
Mama to two sweet boys, a 7yo and a toddler .
The intuitive mind is a sacred gift and the rational mind is a faithful servant. We have created a society that honors the servant and has forgotten the gift. - Albert Einstein
This article explains cytokine storms and H1N1, and how to support your immune system without supporting the cytokine storm:
Steph, DH Jason (1-1-11), DS Owen (10-3-03) and DS Kai (10-13-11)
Rachelle, mommy to 8 year old boys!
My Blog-free homeschooling finds and my lesson plans and link to the new User Agreement
How can I ensure "good hand washing" at dd's school? I just dropped her off at kindergarten for the first time today and there are so.many.kids. I don't know if they wash their hands before snacks. Is it paranoid to ask the teacher/principal? They're supposed to be taking "extra measures" around infection control. I'm worried they'll say it takes too much education time away to wash 25 kids' hands in every class before snack. But I know I've read studies saying a regular handwashing program can significantly cut down infection and absentee rates among primary students. Can anyone direct me to that study? I might have some ammo if I could find it.
Do hand sanitizers work? I could put a bottle in dd's snack pack and drill it into her to use it before snack, or just ask to go to the bathroom before snack so she can wash her hands. But I have, ahem, OCD; which is NOT HELPING. So it's hard to know what's rational and what's germ phobia.
Rachelle, mommy to 8 year old boys!
My Blog-free homeschooling finds and my lesson plans and link to the new User Agreement
beanma, I have those gummy d3s and dd loves them, but if I read people right she should be getting 2000 mcg a day; so that's 5 gummies a day. She would love that. I also have the quick-dissolve SISU brand vitamin D, so maybe a combination? Also, what about the balance with vitamin A someone talked about? How do you get that right? Would a whole-foods multivitamin, supplemented by extra D3, work it all out?
Okay, I guess I'm not backing off.
My experience: we have H1N1 in the house right now. It seems very mild, minimal cough/congestion. Temp was up to 103 briefly yesterday and now back down to 100. 6 kids went home form DS's class in 2 days (Mon/Tues), so we went to the Dr to have a swab & see what it was. She offered tamiflu but also said it has as many side effects of upset stomach, etc so we skipped it. I had a temp of 99 on Mon then nothing more.
My understanding of the danger of this is that as compared to seasonal flu, more people will get it, because it is novel. So, a certain # of people will have complications, a certain number of people will die, just like from seasonal flu. Trouble being that if a much higher percentage have it, it will strain Drs offices and hospitals much more than a normal flu season, possibly making it harder to get care for complications if needed.
My 2 cents: Now that I see how mild it is (so far knock on wood!) I am glad we are getting it early. Our school started Aug 3rd, even a week or so before most around here, and our state is a month or so before many others, so I would guess we are ahead of the curve.
Okay, mom61508, I'm ready to order. Which FCLO do you recommend? Dd doesn't like anything with spice, but there are several to choose from like "mediterranean" or "antioxidant free." Which is your favourite? And why fermented? Can I mix it with anything (it would have to be pretty enticing) to make dd take it? How does it taste? Thanks!
This article explains cytokine storms and H1N1, and how to support your immune system without supporting the cytokine storm:
Thanks alot for sharing this here.
I'm really glad that you're having such a mild case in your household!
May I ask, are you giving anything in particular or just letting it run it's course?
Good luck you guys!
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text:
So You Want to be an Actor?Paperback Nick Hern Books
Free delivery worldwide
Dispatched in 1 business day
When will my order arrive?
- Publisher: NICK HERN BOOKS
- Format: Paperback | 128 pages
- Dimensions: 109mm x 213mm x 18mm | 181g
- Publication date: 11 July 2006
- Publication City/Country: London
- Sales rank: 360,791
Product description
A handbook for aspiring actors by two of the best-known names in the British theatre and television Written by two of the best-known actors in the country, this short book offers practical advice and do's and don'ts to anyone thinking of taking up acting. Both authors are passionate about actor training, know the profession inside out and, as they say in their intro, have more than a hundred years' experience between them! Writing alternate paragraphs throughout the book - and frequently contradicting each other! - they cover the whole gamut from * Applying to drama school * Auditioning * Training * Working in unpaid productions * Doing 'bits' on telly etc etc and on up to * Getting an agent and * Enduring a West End run - should you be so lucky. Published in slimline format (cf. NHB's Actions), this handy but pleasantly unstuffy manual is essential reading - or an essential gift! -for any aspiring actor.
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Author information
Timothy West is best-known on TV for Brass and for playing real people such as Edward VII, Churchill and Beecham, and on stage for classic roles such as Lear, Prospero, Falstaff and the Master Builder. Prunella Scales is world-famous as Mrs Basil Fawlty and well-known on stage and screen for countless other roles often in modern comedy. She has played both Queen Victoria and Queen Elizabeth II.


text:
Jeffrey D. Allred, Deseret News
It's not often I agree with columnist Richard Davis, but I concur with the BYU professor regarding the need for Utah Attorney General John Swallow to be the subject of a special investigation or even impeached ("Cloud over Swallow needs to be resolved soon," May 15). There is enough smoke swirling around the embattled official to reasonably believe there is also some fire that might render him unfit for office.
However, I'm waiting for Davis to come forward with a similar demand for action concerning President Barack Obama or at least his chief lieutenants like Eric Holder and Hillary Clinton. It is now quite clear that the Obama administration has brazenly lied to the American people about a host of serious issues. Let's start with these: the ATF's bungled "Fast and Furious" operation, the false Benghazi cover story about an anti-Islamic video, and the corruption and cronyism behind the funding of "green job" companies like Solyndra. If Davis is so rightly concerned with the integrity of high office holders, should he not also be outraged by the acts of our national leaders even if they happen to share his political beliefs?
Steve Fillerup
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Juice Fasting
Highlights from my 60-day juice fast. Read all about it here! http://meltdownreboot.blogspot.com/ (*I am NOT a doctor, please consult yours before changing your diet*)
Juice Fasting
- 12 Pins
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Yotam Ottolenghi & Sami Tamimi's Basic Hummus #snack #wednesday #appetizer
Yotam Ottolenghi & Sami Tamimi's Basic Hummus Recipe | Food Recipes - Yahoo Shine
Yotam Ottolenghi & Sami Tamimi's Basic Hummus: This recipe is simple, the results are perfect, but here's the real coup: Most from-scratch hummus recipes involve simmering the chickpeas for 1 1/2 to 2 hours. These are done in 20 to 40 minutes. How? See step 2. Briefly cooking the soaked chickpeas directly with baking soda scruffs up the skins & allows them to cook much faster & puree smoother. (Without having to peel by hand.) Simply Genius. Recipe adapted slightly from Jerusalem. | Food52
The Secret Ingredient In Delicious, Creamy Hummus
Hummus/avocado toasts with baked tomato!
Food Drinks Recipes, Food Lunches, Snacks Food, Hummus Avacado Toast, Food Sandwiches, Hummus Avocado Toast, Healthy Food, Tomatoes, Mmm Healthy Lunches
Hummus/avacado toasts with baked tomato! Great breakfast/ snack food
hummus and avocado toasts with roasted tomatoes
My first meal after the fast: Paprika-pepper mahi mahi with black beans, arugula, tomato, and avocado.
Work, Healthy Stuff, Black Beans, Mouths Water, Paprika Pepp Mahi, Mr. Beans, Juice Fast
Paprika-pepper mahi mahi with black beans, arugula, tomato, and avocado.
How did it go? Are you feeling ok after eating again? I wanted to say thank you for posting that stuff, I saw it last night and then went and watched FSND and am so doing this come Jan1. It gives me hope to regain my health and actually feed my body and brain, the weight loss is just a bonus!
Kristen Jenkins
I feel GREAT with eating, but I was recently diagnosed with being lactose intolerant, so now I have to be even MORE aware with what I eat! It was such a great experience, because I was really unhappy with how I felt. I can't say what got me through the 60 days, but taking before and after pictures was really eye-opening. Good luck, and please contact me with any other questions!
Denisse Carrillo
so you wouldnt drink the same juices everyday right?? they were all different?
My before and after a 60 day juice cleanse! I am not a doctor, please consult yours before changing your diet.
Idea, Diet, Reboot Clean, Mommy Meltdown, Food, Doctors, 60 Day Juice Clean, Juice Fast, Juice Cleanse
Wanna do this... When I have control over my own food...
Mommy Meltdown. I feel a juice cleanse coming on.
60day juice fast. amazing results!
"My before and after a 60 day juice cleanse! I am not a doctor, please consult yours before changing your diet." looks like a neat blog for juicing ideas
Kelly Perona
I am a new juicer. My Jack Lalanne juicer spits anything green into the pulp pile. Is there a good, yet cheap juicer for greens that anyone can recommend? Thanks! JuiceLove, Kelly
Ali and Amanda Miller
You are such an inspiration! Me and my sister went on a juice fast for 7 days and did really good but gave in to food. This time we hope to go much longer :)
Danielle Abbs
How much did you loose? And how did you keep it off?
carolyn d
Wow juice diet sounds like a way to be anorexic. Cut out sugar, cut out processed food and exercise is best way to stay thin and keep it off. Starving your body is bad for metabolism and eats the nutrients from your muscles.
Sylvie Ramos
Did you juice every meal? If yes, How were you able to keep it fresh all day? I work ft and that's the hardest part with juicing.
My version of the "Mean Green" juice: 1 bunch spinach, 1 bunch kale, 2 apples, 2 carrots, 1 cucumber, 4 celery stalks, 2 small tomatoes, and a half jalapeño for some kick!
Cucumber, Bunch Spinach, Small Tomatoes, Carrots, Apples, Bunch Kale, Celery Stalks, Half Jalapeo, Mean Green Juices
My version of the "Mean Green" juice: 1 bunch spinach, 1 bunch kale, 2 apples, 2 carrots, 1 cucumber, 4 celery stalks, 2 small tomatoes, and a half jalapeo for some kick!
Rhonda Penny
Yum yum!
Jessica Hotchkiss
Screw the drink, do you remember that glass? I had it!
Kristy McCracken
Think I still have the glass.... If not it broke on my head when the shelf fell when I was a teen!
Heather Pennington
I have this whole set of glasses!
Sara Coon-Thompson
How did I not know that this glass exists?!! Awesome! :D
My favorite breakfast juice! 1 crate of strawberries, 4 apples, 4 carrots.
Health Food, Hello Kristen, Cleaning Hello, Breakfast Juice, Juice Feast, Juice Smoothie, Juice Fast, Breakfast Smoothie, Favorite Breakfast
breakfast smoothie.
Marlene Smith
Your glass makes me laugh! I am going to try the juice!
Chelsea Hartsell
How long did this mixture last you? A meal? A day? Two days?
Kristen Jenkins
That mixture is just one big "meal"! I already drank a lot of the juice before I took this picture. :-)
Clare .
I had that glass when I was little. It was my chocolate milk glass .
Kelly Reed
Krysta Foreman
Bruschetta Juice: 2 large tomatoes, 1 garlic clove, basil to taste!
Garlic Clove, Bruschetta Juice, Juice Raw, Juicy Couture, Juice Inspiration, Basil, Large Tomatoes, Juice Smoothie, Juice Fast
Mommy Meltdown: Day 4-2
Morning Bloody Mary: 4 large tomatoes, 6 celery stalks, 1/2 lemon, and black pepper or cayenne pepper to taste!
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Mommy Meltdown-60 juicing blog
Bloody Mary Juice Recipe
Mommy Meltdown: Day 5
Hilary Myers
are you allowed to add salt and pepper or even cayenne to juice on a juice fast??? That would make me so happy!
jaimie >> glitter with grace
Wow you are brave to add that much Celery to a juice! I am not much of a fan of celery and I put 1/2 the required amount in a recipe once and I ended up having to throw it out I couldn't stand it! Not a good taste for me!
Jamba Juice has three options for meals during a juice fast: Apple 'n Greens, Berry upBEET, and Orange Carrot Karma!
Champoux Weber, Carrots Karma, Berry Beets Smoothie, Healthy, Smoothielee D Juice, Juice Apple, Berries Upbeet, Juice Diet, Berry Upbeet
Juice Diet- Jamba Juice has three options for meals during a juice fast: Apple 'n Greens, Berry upBEET, and Orange Carrot Karma!
Jamba Juice Apple 'n Greens & Berry upBEET
@Daïna Champoux Weber I dont know if they have jamba up there but these sound yummy:) Jamba Juice has three options for meals during a juice fast: Apple 'n Greens, Berry upBEET, and Orange Carrot Karma!
Fruit & Veggie Smoothies
thanks for posting this, i have been looking for options from juice stores. are these made without concentrated juice? does juice it up have any choices that you're aware of??
Kristen Jenkins
I'm from a pretty small town, so we only have a Jamba Juice and a restaurant called Grilla Bites that serve fresh juice. My best advice is to ask ask ASK! You always have a right to know what goes into your drink! I always made sure there wasn't any yogurt or other dairy products added to the juice... just fresh fruits and veggies juiced right in front of you!
Okay, thanks! I did ask both Jamba and Juice-it-Up both said that they put some concentrated juices in all drinks. I will stick with making sure no dairy or other products. I guess a little concentrated juice is okay then?
PS. tried the Berry upBeet today and actually really liked it!
Kristen Jenkins
I would try to avoid concentrated juice it you can, my local Jamba Juice didn't mention it and I watched them make it, but good for you for asking! Try a healthy restaurant, sometimes they offer fresh juice (our local place is called Grilla Bites).
$30 worth of fruits and veggies for 3 days of juice!
Clean Eating, Juice Recipes, Juice Inspiration, Fruit And Veggies, 30 Day Juice Clean, Healthy Food, 60 Day Juice Clean, Juice Fast, Juice Cleanse
Juicing inspiration blog
$30 worth of fruits and veggies for 3 days of juice! juice-fasting
Mommy Meltdown (some good juice recipes)
PRODUCE **juice fast** Mommy Meltdown
Juice cleanse
Juicing for Weight Loss | Reboot With Joe | Fat Sick & Nearly Dead
Sabrina Onweller
How much weight did you lose total?
Kadee Ferkel
I have been juice fasting as well! it's so crazy how much produce I go through every day! lol
Sarah Ruiz
I don't have that kind of money to spend on juicing. How about alternating with one or two juices a day plus a lot of water
Sarah Ruiz
Or eat whole fruits and veggies to keep you full
My 60 day jump-start to better health! I am not a doctor, please consult yours before changing your diet.
Juice Health Inspiration, Fit Blog, Mommy Meltdown, Juice Diet, Weights Loss, Jumpstart Weightloss, Better Health, Juice Fast, Juice Cleanse
well rounded fitness blog
60 day jump-start to better health! Juice diet...
60 day jump-start to better health! I've "Juiced" on my Breville ($100) in the place of about 4 to 5 meals a week. It's really helped in my slow and steady weight loss and road to being healthier. Yay me!
Mommy Meltdown blog. She lost 19 lbs during the juice fast.
60 day jump-start to better health! This blog is so helpful and the girl who writes it is hilarious... // a 60 day juice cleanse??? Ugh... I don't know about that... great juicing recipes though
Fat, Sick, and Nearly Dead juice fast. My 60 day jump-start to better health! I am not a doctor, please consult yours before changing your diet. # Pin++ for Pinterest #
Elizabeth Stoodley
I watched the documentary and am wondering if you have found the 60 day plan that Joe followed. Even on the reboot website they don't have even a 30 day juicing plan. Thanks for any help and I appreciate your posts!
You are crazy! But I give you my respect as a 60 day juice diet is very difficult. I did it for a week and broke.
Ashley Marquess
Drinking nothing but juice for 60 days is called restricting. And can lead to an eating disorder. SO not healthy!
Sarah Charlotte
You're not restricting because you're bombarding your body with more nutrients because you're consuming more fruits & vegetables than you normally would. I'm a vegan and I eat mostly veggies/fruits with some starches anyways and I am far from malnutritioned. I'm 5'8" and 160 pounds. Some people juice unhealthily, like I did after I got my wisdom teeth out- it was so bad that my tongue began to turn black, but that's because I had one smoothy a day and that was it. You can eat unhealthy in any diet form- you just have to monitor and suppliment with vitamins if necessary. This post is great, thanks a bunch!
Santé Naturelle
Fruit and veggie juice is the easiest way to lose bloat and feel great! I am not a doctor, please consult yours before changing your diet.
Veggies Juice, Juice Clean, Mommy Meltdown, Diet Weightloss, Inspiration Weights, Fruit And Veggies, Weights Loss Blog, Bestdiet Loseweight, Juice Fast
Juice Reboot inspiration from Mommy Meltdown. 13 pounds lost in the first 23 days of a 60 day reboot.
Fruit and veggie juice is the easiest way to lose bloat and feel great! I don't know if I could Juice fast or just do fruits and veggies but maybe I could try it...
Kristen Jenkins
I had to take a large handful and roll it up into a "ball", then kind of shove it into the chute and work it down slowly until it juiced. You definitely have to put in some arm work with the lettuce (or at least I did!). You could also try asking this question on the Facebook page here: https://www.facebook.com/#!...
Anna Eidson
Also, Jagoda, it depends a lot on which juicer you bought. The "slow" juicers like Hurom give lots of juice and the pulp is almost cardboard dry.
Brenda Valdez
Jagoda Amanda : What I do when I use spinach or any other leafy green. I juice everything then I use my regular blender, pour the juice from my juicer then I throw my spinach and/or kale and blend it all together.
Ally Plagenza
I'm not trying to be negative but you look your healthiest at day 23, at 60 you look like you're a little under nourished. But kudos to the long fast =)
b P
Wouldn't just putting it all in the blender, adding some water ( or tomatoes etc.) do just as well as juicing all of it? I may keel over before I'm done with this!


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Publications (27)121.26 Total impact
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Article: Altered tissue repair in hevin-null mice: inhibition of fibroblast migration by a matricellular SPARC homolog.[Show abstract] [Hide abstract]
ABSTRACT: Matricellular proteins such as hevin, secreted protein acidic and rich in cysteine, and thrombospondin-2 play an important role during tissue repair through their influence on fundamental cellular activities such as adhesion, migration, proliferation, and extracellular matrix synthesis/reorganization. We have investigated the role played by hevin during excisional and incisional cutaneous wound repair in hevin-null mice. Hevin-null animals both close and heal their skin wounds faster than wild-type animals, as evidenced by enhanced macrophage infiltration of wound beds at early time points, the earlier appearance of mature extracellular matrix, and the overall higher maturity score. In addition, fibrovascular invasion of polyvinyl alcohol sponges was more robust in hevin-null mice, a result indicating that differences in cell migration might underlie the observed alterations in wound repair. Experiments in vitro showed that hevin induced the deadhesion and inhibited the migration of primary dermal fibroblasts in a Rac-1-dependent manner. These findings indicate that the differences in wound repair between hevin-null and wild-type animals can be attributed in part to the deadhesive function of hevin and reduced cell migration within dermal wound beds in which this protein is expressed.Wound Repair and Regeneration 03/2008; 16(2):310-9. DOI:10.1111/j.1524-475X.2008.00370.x · 2.77 Impact Factor
Article: Common deleted genes in the 5q-syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice[Show abstract] [Hide abstract]
ABSTRACT: The commonly deleted region (CDR) for the 5q- syndrome has been identified as a 1.5-megabase interval on human chromosome 5q32. We studied, by real-time reverse-transcription (RT)-PCR, the expression of 33 genes within the CDR that are known to be expressed in CD34+ hematopoietic stem cells. Genes in the 5q- samples that showed the most pronounced decrease in expression compared to non-5q- samples were: solute carrier family 36, member 1 (SLC36A1; 89% downregulated), Ras-GTPase-activating protein SH3 domain-binding (G3BP; 79%), antioxidant protein 1 (ATOX1; 76%), colony-stimulating factor-1 receptor precursor (CSF1R; 76%), ribosomal protein S14 (RPS14; 74%), platelet-derived growth factor receptor-beta (PDGFRB; 73%), Nef-associated factor 1 (TNIP1; 72%), secreted protein, acidic and rich in cysteine (SPARC; 71%), annexin VI (ANAX6; 69%), NSDT (66%) and TIGD (60%). We further studied the hematopoietic system in SPARC-null mice. These mice showed significantly lower platelet counts compared to wild-type animals (P=0.008). Although hemoglobin, hematocrit and mean corpuscular volume (MCV) were lower in mice lacking SPARC, differences were not statistically significant. SPARC-null mice showed a significantly impaired ability to form erythroid burst-forming units (BFU-E). However, no significant differences were found in the formation of erythroid colony-forming units (CFU-E), granulocyte/monocyte colony-forming units (CFU-GM) or megakaryocyte colony-forming units (CFU-Mk) in these animals. We conclude that many of the genes within the CDR associated with the 5q- syndrome exhibit significantly decreased expression and that SPARC, as a potential tumor suppressor gene, may play a role in the pathogenesis of this disease.Leukemia 10/2007; 21(9):1931-6. DOI:10.1038/sj.leu.2404852 · 9.38 Impact Factor
Article: Corrigendum to "Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin"Toxicon 09/2007; 50(3):448-448. DOI:10.1016/j.toxicon.2007.05.006 · 2.58 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Eristostatin, an RGD-containing disintegrin isolated from the venom of Eristicophis macmahoni, inhibits lung or liver colonization of melanoma cells in a mouse model. In this study, transwell migration and in vitro wound closure assays were used to determine the effect of eristostatin on the migration of melanoma cells. Eristostatin significantly impaired the migration of five human melanoma cell lines. Furthermore, it specifically inhibited cell migration on fibronectin in a concentration-dependent manner, but not that on collagen IV or laminin. In contrast, eristostatin was found to have no effect on cell proliferation or angiogenesis. These results indicate that the interaction between eristostatin and melanoma cells may involve fibronectin-binding integrins that mediate cell migration. Mutations to alanine of seven residues within the RGD loop of eristostatin and four residues outside the RGD loop of eristostatin resulted in significantly less potency in both platelet aggregation and wound closure assays. For six of the mutations, however, decreased activity was found only in the latter assay. We conclude that a different mechanism and/or integrin is involved in these two cell activities.Toxicon 07/2007; 49(7):899-908. DOI:10.1016/j.toxicon.2006.12.013 · 2.58 Impact Factor
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ABSTRACT: Matricellular proteins such as SPARC, thrombospondin 1 and 2, and tenascin C and X subserve important functions in extracellular matrix synthesis and cellular adhesion to extracellular matrix. By virtue of its reported interaction with collagen I and deadhesive activity on cells, we hypothesized that hevin, a member of the SPARC gene family, regulates dermal extracellular matrix and collagen fibril formation. We present evidence for an altered collagen matrix and levels of the proteoglycan decorin in the normal dermis and dermal wound bed of hevin-null mice. The dermal elastic modulus was also enhanced in hevin-null animals. The levels of decorin protein secreted by hevin-null dermal fibroblasts were increased by exogenous hevin in vitro, data indicating that hevin might regulate both decorin and collagen fibrillogenesis. We also report a decorin-independent function for hevin in collagen fibrillogenesis. In vitro fibrillogenesis assays indicated that hevin enhanced fibril formation kinetics. Furthermore, cell adhesion assays indicated that cells adhered differently to collagen fibrils formed in the presence of hevin. Our observations support the capacity of hevin to modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly.Journal of Biological Chemistry 10/2006; 281(37):27621-32. DOI:10.1074/jbc.M510507200 · 4.60 Impact Factor
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ABSTRACT: SPARC (secreted protein, acidic, and rich in cysteine) is a matricellular protein that is present in the intervertebral disc; in man, levels of SPARC decrease with aging and degeneration. In this study, we asked whether targeted deletion of SPARC in the mouse influenced disc morphology. SPARC-null and wild-type (WT) mice were studied at 0.3-21 months of age. Radiologic examination of spines from 2-month-old SPARC-null mice revealed wedging, endplate calcification, and sclerosis, features absent in age-matched WT spines. Discs from 3-month-old SPARC-null mice had a greater number of annulus cells than those of WT animals (1884.6 +/- 397.9 [mean +/- SD] vs 1500.2 +/- 188.2, p=0.031). By 19 months discs from SPARC-null mice contained fewer cells than WT counterparts (1383.6 +/- 363.3 vs 1466.8 +/- 148.0, p=0.033). Histology of midsagittal spines showed herniations of lower lumbar discs of SPARC-null mice ages 14-19 months; in contrast, no herniations were seen in WT age-matched animals. Ultrastructural studies showed uniform collagen fibril diameters in the WT annulus, whereas in SPARC-null disc fibrils were of variable size with irregular margins. Consistent with the connective tissue deficits observed in other tissues of SPARC-null mice, our findings support a fundamental role for SPARC in the production, assembly, or maintenance of the disc extracellular matrix.Journal of Histochemistry and Cytochemistry 10/2005; 53(9):1131-8. DOI:10.1369/jhc.5A6687.2005 · 2.40 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The impairment of angiogenesis in aging has been attributed, in part, to alterations in proteins associated with the extracellular matrix (ECM). SPARC (secreted protein acidic and rich in cysteine/osteonectin/BM-40) is a matricellular protein that regulates endothelial cell function as well as cell-ECM interactions. We have previously shown that angiogenesis, as reflected by fibrovascular invasion into subcutaneously implanted polyvinyl alcohol (PVA) sponges, is increased in SPARC-null mice (6-9 months of age) relative to their wild-type (WT) counterparts. In this study, we define the influence of aging on (a) the expression of SPARC and (b) fibrovascular invasion into sponge implants in SPARC-null and WT mice. The expression of SPARC in fibroblasts and endothelial cells derived from young donors (humans mean age less than 30 years and mice 4-6 months of age) and old donors (humans mean age over 65 years and mice 22-27 months of age) decreased 1.6 to 2.3-fold with age. Analysis of fibrovascular invasion into sponges implanted into old (22-27 months) SPARC-null and WT mice showed no differences in percent area of invasion or collagenous ECM. Moreover, sponges from old SPARC-null and WT mice contained similar levels of VEGF that were significantly lower than those from young (4-6 months) mice. In contrast to fibroblasts from young SPARC-null mice, dermal fibroblasts from old SPARC-null mice did not migrate farther, proliferate faster, or produce greater amounts of VEGF relative to their old WT counterparts. However, when stimulated with TGF-beta1, primary cells isolated from the sponge implants, and dermal fibroblasts from both old SPARC-null and WT mice, showed marked increases in VEGF secretion. These data indicate that aging results in a loss of enhanced angiogenesis in SPARC-null mice, as a result of the detrimental impact of age on cellular functions, collagen deposition, and VEGF synthesis. However, the influence of aging on these processes may be reversed, in part, by growth factor stimulation.Journal of Cellular Physiology 09/2005; 204(3):800-7. DOI:10.1002/jcp.20348 · 3.87 Impact Factor
Article: SPARC-thrombospondin-2-double-null Mice Exhibit Enhanced Cutaneous Wound Healing and Increased Fibrovascular Invasion of Subcutaneous Polyvinyl Alcohol Sponges[Show abstract] [Hide abstract]
ABSTRACT: Secreted protein acidic and rich in cysteine (SPARC) and thrombospondin-2 (TSP-2) are structurally unrelated matricellular proteins that have important roles in cell-extracellular matrix (ECM) interactions and tissue repair. SPARC-null mice exhibit accelerated wound closure, and TSP-2-null mice show an overall enhancement in wound healing. To assess potential compensation of one protein for the other, we examined cutaneous wound healing and fibrovascular invasion of subcutaneous sponges in SPARC-TSP-2 (ST) double-null and wild-type (WT) mice. Epidermal closure of cutaneous wounds was found to occur significantly faster in ST-double-null mice, compared with WT animals: histological analysis of dermal wound repair revealed significantly more mature phases of healing at 1, 4, 7, 10, and 14 days after wounding, and electron microscopy showed disrupted ECM at 14 days in these mice. ST-double-null dermal fibroblasts displayed accelerated migration, relative to WT fibroblasts, in a wounding assay in vitro, as well as enhanced contraction of native collagen gels. Zymography indicated that fibroblasts from ST-double-null mice also produced higher levels of matrix metalloproteinase (MMP)-2. These data are consistent with the increased fibrovascular invasion of subcutaneous sponge implants seen in the double-null mice. The generally accelerated wound healing of ST-double-null mice reflects that described for the single-null animals. Importantly, the absence of both proteins results in elevated MMP-2 levels. SPARC and TSP-2 therefore perform similar functions in the regulation of cutaneous wound healing, but fine-tuning with respect to ECM production and remodeling could account for the enhanced response seen in ST-double-null mice.Journal of Histochemistry and Cytochemistry 06/2005; 53(5):571-81. DOI:10.1369/jhc.4A6425.2005 · 2.40 Impact Factor
Article: Matricellular homologs in the foreign body response: Hevin suppresses inflammation, but hevin and SPARC together diminish angiogenesis[Show abstract] [Hide abstract]
ABSTRACT: Implanted foreign materials, used to restore or assist tissue function, elicit an initial acute inflammatory response followed by chronic fibrosis that leads to the entrapment of the biomaterial in a thick, poorly vascularized collagenous capsule. Matricellular proteins, secreted macromolecules that interact with extracellular matrix proteins but do not in themselves serve structural roles, have been identified as important mediators of the foreign body response that includes inflammation, angiogenesis, and collagen synthesis and assembly. In this report we delineate functions of hevin and SPARC, two homologs of the SPARC family of matricellular proteins, in the foreign body response. Despite their sequence similarity, hevin and SPARC mediate different aspects of this fibrotic response. Using mice with targeted gene deletions, we show that hevin is central to the progression of biomaterial-induced inflammation whereas SPARC regulates the formation of the collagenous capsule. Although vascular density within the capsule is unaltered in the absence of either protein, SPARC-hevin double-null capsules show substantially increased numbers of vessels, indicating compensatory functions for these two proteins in the inhibition of angiogenesis. These results provide important information for further development of implant technology.American Journal Of Pathology 04/2005; 166(3):923-33. · 4.60 Impact Factor
- American Journal Of Pathology 03/2005; 166(3):923-933. DOI:10.1016/S0002-9440(10)62312-7 · 4.60 Impact Factor
Article: Quantifying Vasculature: New Measures Applied to Arterial Trees in the Quail Chorioallantoic Membrane[Show abstract] [Hide abstract]
ABSTRACT: A wide variety of measures is currently in use in the morphometry of vascular systems. We introduce two additional classes of measures based on erosions and dilations of the image. Each measure has a clear biological interpretation in terms of the measured structures and their function. The measures are illustrated on images of the arterial tree of the quail chorioallantoic membrane (CAM). The new measures are correlated with widely-used measures, such as fractal dimension, but allow a clearer biological interpretation. To distinguish one CAM arterial tree from another, we propose reporting just three independent, uncorrelated numbers: (i) the fraction of tissue which is vascular (VF0, a pure ratio), (ii) a measure of the typical distance of the vascularized tissue to its vessels (CL, a length), and (iii) the flow capacity of the tissue (P, an area). An unusually large CL would indicate the presence of large avascular areas, a characteristic feature of tumor tissue. CL is inversely highly correlated with fractal dimension of the skeletonized image, but has a more direct biological interpretation.Journal of Theoretical Medicine 01/2005; DOI:10.1080/10273660500264684
Article: Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis[Show abstract] [Hide abstract]
ABSTRACT: SPARC, a matricellular protein that affects cellular adhesion and proliferation, is produced in remodeling tissue and in pathologies involving fibrosis and angiogenesis. In this study we have asked whether peptides generated from cleavage of SPARC in the extracellular milieu can regulate angiogenesis. Matrix metalloproteinase (MMP)-3, but not MMP-1 or 9, showed significant activity toward SPARC. Limited digestion of recombinant human (rhu)SPARC with purified catalytic domain of rhuMMP-3 produced three major fragments, which were sequenced after purification by HPLC. Three synthetic peptides (Z-1, Z-2, and Z-3) representing motifs from each fragment were tested in distinct assays of angiogenesis. Peptide Z-1 (3.9 kDa, containing a Cu2+-binding sequence KHGK) exhibited a biphasic effect on [3H]thymidine incorporation by cultured endothelial cells and stimulated vascular growth in the chick chorioallantoic membrane (CAM). In contrast, peptides Z-2 (6.1 kDa, containing Ca2+-binding EF hand-1) and Z-3 (2.2 kDa, containing neither Cu2+-binding motifs nor EF hands), inhibited cell proliferation in a concentration-dependent manner and exhibited no effects on vessel growth in the CAM. Reciprocal results were obtained in a migration assay in native collagen gels: peptide Z-1 was ineffective over a range of concentrations, whereas Z-2 or Z-3 stimulated cell migration. Therefore, proteolysis of SPARC by MMP-3 produced peptides that regulate endothelial cell proliferation and/or migration in vitro in a mutually exclusive manner. One of these peptides containing KHGK also demonstrated a concentration-dependent effect on angiogenesis.Journal of Biological Chemistry 10/2003; 278(39):37849-57. DOI:10.1074/jbc.M302946200 · 4.60 Impact Factor
Article: Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors[Show abstract] [Hide abstract]
ABSTRACT: Interactions among growth factors, cells, and extracellular matrix regulate proliferation during normal development and in pathologies such as atherosclerosis. SPARC (secreted protein, acidic, and rich in cysteine) is a matrix-associated glycoprotein that modulates the adhesion and proliferation of vascular cells. In this study, we demonstrate that SPARC inhibits human arterial smooth muscle cell proliferation stimulated by platelet-derived growth factor or by adhesion to monomeric type I collagen. Binding studies with SPARC and SPARC peptides indicate specific and saturable interaction with smooth muscle cells that involves the C-terminal Ca2+-binding region of the protein. We also report that SPARC arrests monomeric collagen-supported smooth muscle cell proliferation in the late G1-phase of the cell cycle in the absence of an effect on cell shape or on levels of cyclin-dependent kinase inhibitors. Cyclin-dependent kinase-2 activity, p107 and cyclin A levels, and retinoblastoma protein phosphorylation are markedly reduced in response to the addition of exogenous SPARC and/or peptides derived from specific domains of SPARC. Thus, SPARC, previously characterized as an inhibitor of platelet-derived growth factor binding to its receptor, also antagonizes smooth muscle cell proliferation mediated by monomeric collagen at the level of cyclin-dependent kinase-2 activity.Journal of Cellular Biochemistry 01/2002; 84(4):759-71. DOI:10.1002/jcb.10095 · 3.37 Impact Factor
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ABSTRACT: Studies of therapeutic angiogenesis have generally focused on single growth factor strategies. However, multiple factors participate in angiogenesis. We evaluated the angiogenic potential of a growth factor mixture (GFm) derived from bovine bone. The major components of GFm (SDS-polyacrylamide gel electrophoresis, mass spectrometry, and Western blot) include transforming growth factor-beta1-3, bone morphogenic protein-2-7, and fibroblast growth factor-1. GFm was first shown to induce an angiogenic response in chorioallantoic membranes. Next, myocardial ischemia was induced in 21 dogs (ameroid) that were randomized 3 weeks later to received GFm 1 mg/ml (I), GFm 10 mg/ml (II), or placebo (P) (with investigators blinded to conditions) injected in and adjacent to ischemic myocardium. Dogs were assessed 6 weeks later using quantitative and semiquantitative measures. There were GFm concentration-dependent improvements in distal left anterior descending artery (LAD) opacification by angiography (P: 0.4 +/- 0.2, I: 1.1 +/- 0.14, II: 1.6 +/- 0.3, angiographic score p = 0.014). Histologically, there was also concentration-dependent vascular growth response of relatively large vessels (P: 0.21 +/- 0.15, I: 1.00 +/- 0.22, II: 1.71 +/- 0.18, vascular growth score p = 0.001). Resting myocardial blood flow (colored microspheres) was not significantly impaired in any group. However, maximum blood flow (adenosine) was reduced in ischemic territories and did not improve in GFm-treated hearts. GFm, a multiple growth factor mixture, is a potent angiogenic agent that stimulates large vessel growth. Although blood flow did not improve during maximal vasodilatory stress, large intramyocardial collateral vessels developed and angiographic visualization of the occluded distal LAD improved significantly. The use of multiple growth factors may be an effective strategy for therapeutic angiogenesis provided a more effective delivery strategy is devised that can achieve improved maximum blood flow potential.Journal of Pharmacology and Experimental Therapeutics 12/2001; 299(2):494-500. · 3.86 Impact Factor
Article: Ectopic expression of SPARC in Xenopus embryos interferes with tissue morphogenesis: Identification of a bioactive sequence in the C-terminal EF hand[Show abstract] [Hide abstract]
ABSTRACT: SPARC is a matricellular Ca(2+)-binding glycoprotein that exhibits both counteradhesive and antiproliferative effects on cultured cells. It is secreted by cells of various tissues as a consequence of morphogenesis, response to injury, and cyclic renewal and/or repair. In an earlier study with Xenopus embryos we had shown a highly specific and regulated pattern of SPARC expression. We now show that ectopic expression of SPARC before its normal embryonic activation produces severe anomalies, some of which are consistent with the functions of SPARC proposed from studies in vitro. Microinjection of SPARC RNA, protein, and peptides into Xenopus embryos before endogenous embryonic expression generated different but overlapping phenotypes. (a) Injection of SPARC RNA into one cell of a two-cell embryo resulted in a range of unilateral defects. (b) Precocious exposure of embryos to SPARC by microinjection of protein into the blastocoel cavity was associated with certain axial defects comparable to those obtained with SPARC RNA. (c) SPARC peptides containing follistatin-like and copper-binding sequences were without obvious effect, whereas SPARC peptide 4.2, corresponding to a disulfide-bonded, Ca(2+)-binding domain, was associated with a reduction in axial structures that led eventually to complete ventralization of the embryos. Histological analysis of ventralized embryos indicated that the morphogenetic events associated with gastrulation might have been inhibited. Microinjection of other Ca(2+)-binding glycoproteins, such as osteopontin and bone sialoprotein, resulted in phenotypes that were unique. We probed further the structural correlates of this region of SPARC in the context of tissue development. Co-injection of peptide 4.2 with Ca2+ or EGTA, and injection of peptide 4.2K (containing a mutated consensus Ca(2+)-binding sequence), demonstrated that the developmental defects associated with peptide 4.2 were independent of Ca2+. However, the disulfide bridge in this region of SPARC was found to be critical, as injection of peptide 4.2AA, a mutant lacking the cystine, generated no axial defects. We have therefore shown for the first time in vivo that the temporally inappropriate presence of SPARC is associated with perturbations in tissue morphogenesis. Moreover, we have identified at least one bioactive region of SPARC as the C-terminal disulfide-bonded, Ca(2+)-binding loop that was previously shown to be both counteradhesive and growth-inhibitory.Journal of Histochemistry and Cytochemistry 06/1997; 45(5):643-55. DOI:10.1177/002215549704500502 · 2.40 Impact Factor
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ABSTRACT: SPARC (secreted protein, acidic and rich in cysteine), also called osteonectin or BM-40, is a collagen-binding glycoprotein secreted by a variety of cells and is associated with functional responses involving tissue remodeling, cell movement and proliferation. Because SPARC and monocytes/macrophages are prevalent at sites of inflammation and remodeling in which there is connective tissue turnover, we examined the effect of SPARC on monocyte matrix metalloproteinase (MMP) production. Treatment of human peripheral blood monocytes with SPARC stimulated the production of gelatinase B (MMP-9) and interstitial collagenase (MMP-1). Experiments with synthetic peptides indicated that peptide 3.2, belonging to the alpha helical domain III of SPARC, is the major peptide mediating the MMP production by monocytes. SPARC and peptide 3.2 were also shown to induce prostaglandin synthase (PGHS)-2 as determined by Western and Northern blot analyses. The increase in PGHS-2 stimulated by SPARC or peptide 3.2 correlated with substantially elevated levels of prostaglandin E2 (PGE2) and other arachidonic acid metabolites as measured by radioimmunoassay and high performance liquid chromatography (HPLC), respectively. Moreover, the synthesis of MMP was dependent on the generation of PGE2 by PGHS-2, since indomethacin inhibited the production of these enzymes and their synthesis was restored by addition of exogenous PGE2 or dibutyryl cAMP (Bt2cAMP). These results demonstrate that SPARC might play a significant role in the modulation of connective tissue turnover due to its stimulation of PGHS-2 and the subsequent release of PGE2, a pathway that leads to the production of MMP by monocytes.Journal of Cellular Physiology 01/1997; 173(3):327-34. DOI:10.1002/(SICI)1097-4652(199712)173:3<327::AID-JCP4>3.0.CO;2-P · 3.87 Impact Factor
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ABSTRACT: Human SPARC has been cloned by the polymerase chain reaction from an endothelial cell cDNA library and expressed in Escherichia coli as a biologically active protein. Transcriptional expression of the insert cDNA was dependent on the activation of the T7 RNA polymerase promoter by isopropylgalactopyranoside. Two forms of recombinant SPARC (rSPARC) protein were recovered from BL21 (DE3) E. coli after transformation with the plasmid pSPARCwt: a soluble, monomeric form of rSPARC and an insoluble, aggregated form sequestered in inclusion bodies. The isolation of the soluble form of rSPARC was accomplished by anion-exchange, nickel-chelate affinity, and gel filtration chromatographies. The isolated protein was an intact, full-length polypeptide of 293 amino acids by the following criteria: N-terminal amino acid sequence, reaction with anti-SPARC immunoglobulins specific for N-terminal and C-terminal sequences, and interaction of the C-terminal histidine tag of rSPARC with a nickel-chelate affinity resin. Circular dichroism and intrinsic fluorescence spectroscopy indicated that the conformation of rSPARC was dependent on interaction with Ca2- ions. The recombinant protein inhibited cell spreading and bound specifically to bovine aortic endothelial cells. Levels of bacterial endotoxin (< 18 pg/microgram rSPARC) present in rSPARC preparations were below the threshold that affects the behavior of these endothelial cells. These conformational and biological properties of rSPARC are consistent with previously described characteristics of the native protein. The purification of biologically active rSPARC, as well as mutated forms of the protein, will provide sufficient quantities of protein for the determination of structure/function relationships.Archives of Biochemistry and Biophysics 02/1996; 325(1):8-19. DOI:10.1006/abbi.1996.0002 · 3.04 Impact Factor
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ABSTRACT: SPARC (Secreted Protein, Acidic and Rich in Cysteine)/osteonectin is a secreted glycoprotein that exhibits restricted expression in murine adult and embryonic tissues and is associated with cell migration, matrix mineralization, steroid hormone production, cell cycle regulation, and angiogenesis. We produced a monoclonal antibody, MAb SSP2, against a Ca(2+)-binding region of SPARC and evaluated the immunoreactivity of normal and malignant tissue from 118 human samples. In normal tissue we found restricted and moderate reactivity with SSP2 in steroidogenic cells, chondrocytes, placental trophoblasts, vascular smooth muscle cells, and endothelial cells. Strong reactivity was found in fibrocytes and endothelial cells involved in tissue repair and in invasive malignant tumors, including those of the gastrointestinal tract, breast, lung, kidney, adrenal cortex, ovary, and brain. We conclude that SSP2 is a useful reagent for detection of SPARC in human tissue. Given the broad reactivity of malignant tissues, we propose that SPARC expression might contribute to some aspects of tumor progression.Journal of Histochemistry and Cytochemistry 09/1995; 43(8):791-800. DOI:10.1177/43.8.7622842 · 2.40 Impact Factor
Article: SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function[Show abstract] [Hide abstract]
ABSTRACT: SPARC (secreted protein acidic and rich in cysteine) can be selectively expressed by the endothelium in response to certain types of injury and induces rounding in adherent endothelial cells in vitro. To determine whether SPARC might influence endothelial permeability, we studied the effect of exogenous SPARC on the movement of 14C-labeled bovine serum albumin across postconfluent bovine pulmonary artery endothelial cells. SPARC increased (P < 0.02) transendothelial albumin flux in a dose-dependent manner at concentrations > or = 0.5 microgram/ml. At a fixed dose (15 micrograms/ml), exposure times > or = 1 h augmented (P < 0.005) albumin flux by 1.3- to 3.6-fold; this increase was blocked by anti-SPARC antibodies but not by inhibition of protein synthesis. Barrier dysfunction was not associated with loss of cell viability. Monolayers exposed to SPARC exhibited a rounded morphology and intercellular gaps. Prior stabilization of F-actin with phallicidin protected against the changes in barrier function (P = 0.0001) that were otherwise induced by SPARC. Bovine aortic and retinal microvascular endothelia also responded to SPARC. We propose that SPARC regulates endothelial barrier function through F-actin-dependent changes in cell shape, coincident with the appearance of intercellular gaps, that provide a paracellular pathway for extravasation of macromolecules.Proceedings of the National Academy of Sciences 04/1994; 91(8):3448-52. DOI:10.1073/pnas.91.8.3448 · 9.81 Impact Factor
Article: Differential effect of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts[Show abstract] [Hide abstract]
ABSTRACT: SPARC (secreted protein, acidic and rich in cysteine), also known as osteonectin, is an extracellular Ca+2-glycoprotein that inhibits the incorporation of [3H]-and delays the onset of S-phase in synchronized cultures of bovine aortic endothelial (BAE) cells. This effect appears not to be dependent on the functional properties of SPARC associated with changes in cell shape or inhibition of cell spreading. In this study we investigate the conditions under which cell cycle modulation occurs in different types of cells. Human umbilical vein endothelial cells, a transformed fetal BAE cell line, and bovine capillary endothelial cells exhibited a sensitivity to SPARC and a cationic peptide from a non-Ca+2-region of SPARC (peptide 2.1, 0.2—0.8 mM) similar to that observed in BAE cells. In contrast, human foreskin fibroblasts and fetal bovine ligament fibroblasts exhibited an increase in the incorporation of [3H]-in the presence of 25 μM—0.2 mM peptide 2.1; inhibition was observed at concentrations in excess of 0.4 mM. This biphasic modulation could be further localized to a sequence of 10 amino acids comprising the N-terminal half of peptide 2.1. A synthetic peptide from another cationic region of SPARC (peptide 2.3) increased [3H]-incorporation by BAE cells and fibroblasts in a dose-dependent manner. In endothelial cells, a stimulation of 50% was observed at a concentration of 0.01 mM; fibroblasts required ∼ 100-fold more peptide 2.3 for levels of stimulation comparable to those obtained in endothelial cells. The observation that SPARC and unique SPARC peptides can differentially influence the growth of fibroblasts and endothelial cells in a concentration-dependent manner suggests that SPARC might regulate proliferation of specific cells during wound repair and remodeling. © 1993 Wiley-Liss, Inc.Journal of Cellular Physiology 01/1993; 154(1):53 - 63. DOI:10.1002/jcp.1041540108 · 3.87 Impact Factor
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Benaroya Research InstituteSeattle, Washington, United States
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Atlanta, Georgia, United States
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- • Department of Surgery
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University of TorontoToronto, Ontario, Canada


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Survey: Majority Of Americans Feel Religion Is The Answer To All Of Today's Problems
PHILADELPHIA (CBS) – What's the answer to all of today's problems?
Religion, at least according to 57% of Americans.
In the May 8 – 11 Gallup Values and Beliefs survey, just over 1,000 adults were asked whether or not religion can "answer today's problems."
Fifty-seven-percent, apparently, said yes.
But if you find that percentage a bit high, it's important to have some context. Gallup says it's actually down – way down – since the 1950s, when 82% said religion was the solution to the problems of the era.
Meanwhile, 30% of adults surveyed in the latest poll said the idea of religion as a balm for modern issues is "old fashioned and out of date."
Perhaps unsurprisingly, older adults, people from the South and conservatives were the most likely to view religion as a problem solver. Women were slightly more likely than men to place greater importance on religion.
For more information on the Gallup survey, click here.
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Is America Any Place For a Nice Hispanic Girl?
By DONATELLA LORCH
Published: April 11, 1996
FELISA VALETA remembers blowing out the candles on her 13th-birthday cake with the wish, "Please, God, let me remain a virgin until I get married."
Now 23, Miss Valeta, a first-generation American whose parents came from Colombia, laughs at the earnestness of that wish. Yet, she said her father and grandmother still believe that virginity must last until marriage. "I know they feel that if you step over that boundary you are a tramp," she said.
Miss Valeta's mother, Gala, who is now 58, came to the United States from Colombia in 1969 and met her husband, a widower, in Queens. In a bold step, she married him against her mother's wishes. He did not want her to get a job, but she insisted, and taught high school, as she had in Colombia.
"I grew up in a culture where women are superwomen," Mrs. Valeta said. "You do it all and you don't complain." Still, the same woman who shines her husband's shoes every day chafed when her mother, who is 88 and who lives with the family, lectured her when she did not get up to take her husband a glass of water.
"I felt my mother was judging me," she said, "but I didn't disagree openly because that's a sign of disrespect."
Ten years ago, with three generations under one roof, two daughters rebelling and Mrs. Valeta suffering from stress and depression that she believes gave her an ulcer and a heart attack, the Valetas did something unusual among Hispanic families: they went to a family therapist, to work through what their psychologist described as the cultural confusion of adapting to American life. Mrs. Valeta's husband, John, and her mother, Felisa Cruz, were the most reluctant to attend.
The acculturation problems of families like the Valetas will loom larger in the mental health picture of the United States in the not-too-distant future: the Census Bureau estimates that by the year 2050, Hispanics will make up 24.5 percent of the population. Even today, when Hispanics are about 10.2 percent of the population, there are almost 11 million women of Hispanic origin in the country; psychologists say that women, who do most of the child-rearing, are on the front lines of the acculturation process.
Experts describe the mind-set of traditional Latin womanhood as "marianismo," focusing on the Virgin Mary as an ideal of duty, self-sacrifice, passivity and chastity. The Valetas' therapist, Dr. Carmen Inoa Vasquez, is an author of "The Maria Paradox: How Latinas Can Merge Old World Traditions With New World Self-Esteem," to be published next week by G. P. Putnam's Sons ($22.95). Dr. Vasquez, a Dominican-born psychologist who is the director of the bilingual mental health clinic at Bellevue Hospital, is a pioneer in the growing field of counseling for Hispanic women. The book, written with Dr. Rosa Maria Gil, a psychotherapist who is the vice president of mental health and dependency services at the New York City Health and Hospitals Corporation, it is one of the first books on the topic. Based on the authors' own experiences and hundreds of therapy sessions with patients, the book is intended to help women identify their problems and find compromises that are consistent with their own cultures, Dr. Vasquez said.
Dr. Odette Alarcon, a psychiatrist and senior research scientist at the Center for Research for Women at Wellesley College, said that Spanish-Roman Catholic traditions that she equates with a sense of fatalism are part of marianismo, which compounds the problems.
Mrs. Valeta fits this pattern in many ways. She calls herself old-fashioned, but she has also grown conscious of what she does not like in her native culture. For example, she said: "If your husband has a girlfriend, you're supposed to close your mouth. After all, you're the one who is married, not your husband. My mother thinks you should be that way. You're supposed to serve your master."
While she wholeheartedly disagrees, tradition dies hard. Mrs. Valeta has lectured her other daughter, Vivian, 22, on how her future husband should not be allowed to do housework.
In their native country, marianismo afforded women protection and respect, but in America it perpetuates a value system that is at odds with their adopted culture. And women in particular are caught in these contradictions, especially as American-born generations grow up.
As Dr. Vasquez put it: "When a Latina comes to the U.S., she tries to continue being what she was back home at the same time as what she has become here. There are a lot of pressures."
While bilingual mental-health clinics exist in New York City and other cities with large Hispanic populations like Los Angeles and Houston, the demand exceeds the supply, Dr. Vasquez said. Her bilingual clinic at Bellevue Hospital has about 150 Hispanic patients but only one part-time psychiatrist, a part-time director, two psychologists and two trainee psychologists. Such clinics cater mostly to poor or working-class immigrants, many of whom are not fluent in English.
By contrast, Dr. Vasquez's and Dr. Gil's private patients are more likely to be teachers, social workers, lawyers, doctors -- even judges.


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Eleven miles off the coast of Arbroath in Scotland, the Bell Rock Lighthouse, standing on the Inchcape Reef, has withstood two centuries of vicious storms and powerful North Sea surges to safely guide ships away from the dangers beneath. The Feb. 1 marked the 200th anniversary of the lighting of the beacon and sponsored by Inchcape Shipping Services, the anniversary will be celebrated with a series of events in Edinburgh, Arbroath and beyond.
HRH The Princess Royal, patron of the Northern Lighthouse Board, will be in Edinburgh to hold a reception at Holyrood House on the evening of Thursday February 3, and to open a conference on "The Bell Rock Lighthouse, the Stevensons, and Emerging Issues in Aids to Navigation" being held at the Royal Society of Edinburgh, on Friday 4th.
"We are delighted to be sponsoring these events marking such a remarkable engineering feat, said Capt. Claus Hyldager, CEO of Inchcape Shipping Services. "It clearly meant a great deal to our founder, James Lyle Mackay who, upon the Lighthouse's Centenary in 1911, took his title from the Inchcape Reef, and to whom we owe our name today.
"We have taken this opportunity to launch the ISS Lighthouse Relay Voyage – a Corporate Social Responsibility initiative inspired by the Bell Rock Lighthouse's altruistic purpose. As a company with offices in over 60 countries around the world, Inchcape Shipping Services is committed to giving something back to the communities where we do business and this project will see us helping the sick, underprivileged and disadvantaged within those communities."
The events have been organized by the Royal Society of Edinburgh and the Northern Lighthouse Board.
Lord Wilson of Tillyorn, President of the RSE, said: "The story of the Bell Rock Lighthouse and those who have been a part of its history, from its designer to its keepers, is inspirational. But that story is not over. 200 years on, its light is still shining. Those years have seen huge changes, from the automation of lighthouses to advances in the technologies used in navigation. But these solid beacons will continue to be vital into the future. GPS signals can fail. Lighthouses stand firm as immovable markers of dangers lurking beneath the surface of the ocean".
These events are part of a wider program of celebrations: Bell Rock 200. The program includes the major exhibition "Shining Lights" at the National Museum of Scotland which runs until April 3, and the "Year of Light" community-based celebrations in Arbroath.
On July 31, Border Patrol Search Trauma and Rescue (BORSTAR) agents and CBP Office of Air and Marine rescued a man who was reported missing the previous morning.
Heidmar announced the promotion of Duncan Ross to Fleet Manager.
Duncan joined Heidmar's London office in 2012 as vessel manager. Prior to joining Heidmar,
A fire broke out on board USS Mount Whitney (LCC 20) while the ship was in Viktor Lenac Shipyard (Rijeka, Croatia) July 31, 2015.
There were no personnel injuries in the fire,


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By Ryan Clark | October 09, 2011 | Comments
-- Chris Jericho answered a series of fan questions Saturday on Twitter and was asked if he plans on returning to WWE.
He responded, "No plans as of right now."
-- Since parting ways with WWE in August, Melina has been posting and favoring messages on Twitter which suggest that her relationship with John Morrison is not picture perfect. She interestingly added the following messages to her Favorites list late last week.
"I'm proud of my heart. It's been played, stabbed, cheated, burned and broken, but somehow still works."
"I never get jealous when I see my ex with someone else, because my parents always taught me to give my used toys to the less fortunate."
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Hotel Oldenkott
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A new day.. Germany
An early start to head out of the Netherlands into Germany on a beautiful sunny day. In the city of Cologne crossing the River Rhine 12000km , a major trade artery for Germany. Castles everywhere! 4711 cologne invented here in 17th century. Arrived in the beautiful riverside village of Boppard the centre of the mid Rhine area! Postcard picture perfect!! ...
Another week working on the farm!
... go for two weeks without it. I succeeded, and for that I am proud of myself. The next chance I get, I'm going to eat a big chunk of meat! I'm afraid my body is craving protein. The rest of the week we did a lot of different work, and had a lot of fun. We chopped wood, sawed logs, harvested chamomile, weeded the garden, trimmed hedges, made jam, baked bread, mowed lawns, fed chickens, collected eggs, made a cooking box, formed flower beds, cooked meals, picked salads (which ...
Organic Farming! Working hard and eating healthy!
... labor. I have always enjoyed farm work so it is a great place to be. Nature is all around, and often we get to work alone for hours at a time, often we have each other working around us. There are three other WWOOFers here, a couple from the States, and a girl from the States as well. It had been fun getting to know then. That and our hosts, who are a really awesome elderly couple, makes seven of us. The other WWOOFers are leaving this weekend, so we ...
The Sun Had His Hat On
It was the Navigator's turn to get the tea in the morning, but despite the alarm being on her side and going off twice at 0700hrs, she chose to ignore it. After some encouragement, she did get up. After the usual 2 hour get ready go...we entered the German Autobahn system and whilst we happily tootled along at 90KPH, the ever fast German drivers were going past ...
Germany/Cologne/Rhine Cruise
On our way to Cologne. We were warned about pickpockets when we arrived in Amsterdam and to watch our bags by the Tour Director. Drama began before we left. Having boarded the coach,Tour Director approached by a man who had a leather wallet of keys and showed him where he found them other side of bus. Nobody on bus claimed the keys and they were left at hotel reception desk. Just after coach left hotel Tour Director discovered his bag was missing ...


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Jean-Claude Van Damme is at it again — emulating Arnold, that is. Like Schwarzenegger, who starred in the video for Guns N' Roses' Terminator 2 hit, "You Could Be Mine," the Muscles from Brussels has hooked up with a cool band of his very own. The Smithereens' clip for "Time Won't Let Me," a 1966 Outsiders' classic the power popsters covered for the bare-chested Belgian's upcoming adventure film, Time Cop, features Van Damme as a time machine operator who whisks the New Jersey group's members through history. Says Smithereens frontman/guitarist Pat DiNizio: "I was always a sucker for the action genre. In fact, I bought Hard Target on laserdisc." Van Damme, clueless about his costars before they met, was nonetheless charmed, if typically voluble: "They're nice, funny guys." Expect to see the video on MTV in the next month.
Jean-Claude Van Damme rocks
Jean-Claude Van Damme rocks -- The Muscles from Brussels adds music video star to his résumé
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Jamie McMurray Karting Wreck
Posted by jaywpennell on Jul. 29, 2010
Blondes suck at math, pugs rock at climbing, and sharks rock at EVERYTHING!
Every other Monday, our team of blacksmiths and craftsman will be building ...
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Total Enrollment: 13,554
Institution Size: 10,000 - 19,999
Campus Setting: Urban
Religious Affiliation: Not applicable
Highest Degree Offered: Doctoral and first-professional
School Calendar Type: Semester
Total Undergrad Enrollment: 11,593
Total Grad Enrollment: 1,961
Admissions Requirements:
High School GPA
High School Rank
Test Scores
Accepted Credit:
Advanced Placement
It combines a small liberal arts school with a medium sized research institution - you get the best of both worlds - small classes with excellent professors and great opportunities for doing...
When I graduated in 2005 there was no official student union and a major housing crunch (most frosh were in triples). Since then a brand new student union has opened along with new residential...
The town it is in. Burlington is rich and culture and always moving. Its a beautiful town with a diverse range of people
Its so much money. I think the most expensive state school in the US.
Vermont offers the best of culture and country. One can attend a concert, yet be on the ski slopes within a half an hour. For the students, it is lovely, as the vibrant downtown has a wonderful mix...
We are still working on diversity. There is also a push to consolidate sports which has resulted in the college closing down baseball and softball in spite of the fact that we produced major league...
Another awesome thing is The music concerts!
I wish I knew the freaking PRICE!
Another awesome thing is The library was very large compared to other universities of the same size.
I wish I knew look at the dorms
Every student at this school needs good walking legs


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Height: 6-4 Weight: 270 lbs.
Born: January 16, 1960 in McKeesport, PA
High School: South AlleghenyCollege: Penn St. (school history)
Weighted Career AV (100-95-...): 1 (12808th overall since 1950)
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Awesome, nice people.
Our groceries were already in our Disney resort room when we checked in! We will definitely use Garden Grocer on our next visit to Orlando!
It was such a relief to hear about this service! We stay at the villas and don't rent a car so to have this option was fantastic. Prices for groceries are slightly higher than you would pay if you bought them yourself, but cheaper and healthier than eating out for 3 meals a day.


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Did α-Synuclein and Glucocerebrosidase Coevolve? Implications...Abstract Mutations in the GBA1 gene are associated with increased risk of Parkinson's disease, and the protein produced by the gene, glucocerebrosidase, interacts with α-synuclein, the protein at the center of the disease etiology. One possibility ... Plosone.org, 3 days ago
ICT industry expects stronger results as new services come on-line in Indonesia
Despite its strong long-term growth prospects, 2014 was a challenging year for Indonesia's telecommunications sector, as operators faced fierce competition and market saturation, while average revenue per user (ARPU) continued to decline. The IT ...Oxford Business Group, 1 week ago
Global Electronic Security Systems Market
G NEW YORK, June 18, 2015 /PRNewswire/ This report analyzes the worldwide markets for Electronic Security Systems in US$ Million by the following Categories/Segments: Alarms, Electronic Access Control Systems, CCTV/Video Surveillance Equipment, and ...TMC Net, 1 month ago
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text: We stayed at this hotel on points. It was outstanding value. The room was smaller than some we have been in. We had a one queen on the ground floor (drive-up). There was a side table and light on only one side of the bed with a cupboard right beside your head on the other side. Even though this is... More