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5:19 pm
Wed May 29, 2013
From the Archive: Remembering Jazz Pianist Mulgrew Miller
Jazz pianist and educator Mulgrew Miller passed away today at the age of 57. He was said to be a leader among contemporary jazz pianists. In this commentary recorded in 2007, Dr. Brian Clardy, Murray State Assistant Professor of History and host of Cafe Jazz Wednesday nights, talks about why Miller was more than just a listening experience. To honor Miller's legacy, Brian will play several selections of his work, along with work by contemporaries tonight (May 29) on Cafe Jazz.


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Partially lost to the sea in the 14th century, finally destroyed by Henry VIII with the dissolution of the monasteries. The remains of the refectory, gates and curtain wall have been continuously maintained through the centuries.
Photo taken in Suffolk Coast & Heaths AONB, Dock Lane, Melton, Woodbridge, Suffolk IP12 1PE, UK


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Jazz at Lincoln Center (JALC) is the world's largest not-for-profit arts organization committed to promoting the appreciation and understanding of jazz through performance, education, and preservation, under Artistic Director Wynton Marsalis. Jazz at Lincoln Center's new homeFrederick P. Rose Hallat New York's Columbus Circle, the first education, performance, and broadcast facility devoted to jazz, opened in fall 2004. JALC offers a chance to grow with one of New York's fastest growing arts organizations.
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How to deal when you and your BFF are crushing on the same dude
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Historical Events Happened In 1501
Tuesday, 28 July 2015
Jan 03 Ali Sjir Neva'i [Fani], Turkish poet/author, dies at 59 in the year 1501.
Jan 14 In the year 1501 martin Luther, age 17, enters the University of Erfurt.
Jan 17 On this day in history cesare Borgia returns in triumph to Rome from Romagna
Jan 17 In the year 1501 leonhard Fuchs, Germany, botanist (History of Plants)
Feb 24 Sixt(us) Birck [Xystus Betulius], German writer (Suzanna) in the year 1501.
Mar 20 Jean Carondelet, lawyer/chancellor of Burgundy (1480-96), dies at 72 on this day in history.
Apr 23 On this day in history portuguese navigator Pedro Cabral & 6 ships return to Lisbon
May 06 Marcellus II, [Marcello Cervini], Italy, humanist/Pope (1555, 22 days) on this day in history.
May 14 In the year 1501 lisbon Portugal, explorer Gaspar Corte Réal leaves on his second voyage to Newfoundland; never heard from again.
May 20 Joao da Nova Castell discovers Ascension Islands in the year 1501.
May 22 Robert Gaguin, French writer/diplomat (Arte Metrificandi), dies at 66 on this day in history.
Jun 17 On this day in history jan I Olbracht, King of Poland, dies
Jul 15 In the year 1501 explorer Pedro Cabral back in Lisbon
Jul 27 In the year 1501 copernicus formally installed as canon of Frauenberg Cathedral
Sep 24 Girolamo Cardano, Italy, mathematician/astrologer (Ars Magna-1545) on this day in history.
Sep 25 Dzore Drzic, Croatish poet, dies in the year 1501.
Oct 13 In the year 1501 maximilian of Austria & Louis XII sign Treaty of Trente
Oct 15 English crown prince Arthur marries Catharina of Aragon in the year 1501.
Nov 04 In the year 1501 philip de Blank & Juana "la Loca" depart to Spain


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Daniel Binelli was born on March 20, 1946 in Buenos Aires, Argentina. He is known for his work on The Official Story (1985), India pravile (2003) and Tango, Our Dance (1988). See full bio »
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Aug 29
6th annual fundraiser event with NC Stars in the Round songwriter circleTickets Save
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is her name, not a band. But with the Spark behind her, she delivers "great, roving Americana with pipes to spare," (The Pinhook, Durham, NC). Ranging from soft twang with impeccable harmonies to driving rock rhythms full of late-night swagger, Mary's music draws in fans of...See Full Bio


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by Dr. Jekyll in Lunatic Laboratories
Scientists have gained new insight into fragile X syndrome — the most common cause of inherited intellectual disability — by studying the case of a person without the disorder, but with two of its classic symptoms.... Read more »
Myrick LK, Deng PY, Hashimoto H, Oh YM, Cho Y, Poidevin MJ, Suhl JA, Visootsak J, Cavalli V, Jin P.... (2015) Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures. Proceedings of the National Academy of Sciences of the United States of America. PMID: 25561520
by Cobb & Hecht in Do You Believe In Dog?
2015 is a bright and shiny new year for canine science! But first, this face:After being a dog-less household for eight months (you might remember we sadly farewelled Elke in 2013 and gut-wrenchingly, also old man Caleb, in the first half of 2014) we welcomed a new member to the family at the end of 2014. Those paws. Not photoshopped.If I'm honest with you, I'd been stalking PetRescue quietly for a month or so, not really sure if the time was right, but also open to being inspired to make it the right time to welcome a new dog into our lives. I eventually made a call to a shelter a long, long way away about a dog I'd seen who looked like the kind of dog I thought would be a good fit for our family over the next fifteen years. His profile had been up for a few weeks and I was concerned he might be nearly out of time to be adopted. The lovely shelter staff let me know he'd actually just been adopted that morning - I was thrilled for him and his new family. Probably a good thing anyway, that shelter was 5 hours' drive away - no small distance. The following day I received a message from the shelter staff - there was another dog - a younger pup, similar type, would I be interested? "Send me some photos and a video clip of him" I said... and they did. I told Julie about the pup and how far away he was. "Love this story!! Keep it coming ;)" she said via email. Huh, I thought - what an adventure this could be to meet a new family member - and luckily, my partner agreed!So a week later, coincidentally on my birthday, we headed off after lunch on a 400km (that's 250miles to those of you who prefer miles) drive to a faraway coastal town south west of Melbourne to meet this four month old pup. He had come into the regional shelter as a stray. Whether he was deliberately dumped, wandered off through an open gate, or actively strayed by jumping a fence - we'll never know. That's part of the shelter dog story - not necessarily knowing what came before. What we do know is this: He was not identified by microchip, had no collar with ID and was not desexedNo one came looking for him during his two weeks in the shelterOn meeting us, he was excitable, mouthy and jumpy, but calmed down fairly quicklyWe have named him Rudy (roo-dee), inspired by Rudolph as it was Christmas weekWhat is he?We've been asked that a lot! Rudy is a Staghound. Staghounds in Australia are similar to Lurchers and Longdogs in the UK - a 'type' of dog, rather than a breed. Staghounds are generally greyhound x deerhound with maybe a bit of whatever else was around the area in them too. They can vary widely in looks as they are bred with an emphasis on health, performance and longevity, rather than to a physical standard. They are generally bred to help with hunting in rural areas, but like greyhounds, can make excellent companions as well. As you'd expect, they are highly distracted by moving things.A diet of scienceInevitably, we're feeding Rudy a daily dose of science. If you want to keep up with how he's going, you can follow the #RaisingRudy hashtag on Twitter, keep up with our Do you Believe in Dog? Facebook posts, or check in here at the blog for regular updates. I've never claimed to be a dog trainer, but I'm certainly aware of the importance of putting the wide array of scientific findings into practice with our dogs to help them have a great life and help us enjoy our time with them. So far, over the first couple of weeks Rudy's been with us, this has looked a bit like this:... Read more »
KIDD A. H. (1989) FACTORS IN ADULTS' ATTITUDES TOWARD PETS. Psychological Reports, 65(3), 903-910. DOI: http://dx.doi.org/10.2466/pr0.19184.108.40.2063
Hiby E.F., Rooney N.J., & Bradshaw J.W.S. (2004) Dog training methods: their use, effectiveness and interaction with behaviour and welfare. . Animal Welfare, 13(1), 63-70. info:other/http://www.ingentaconnect.com/content/ufaw/aw/2004/00000013/00000001/art00010
by Dr. Jekyll in Lunatic Laboratories
Does it seem like no matter what you do, you still can't shed the pounds? You know what to eat, how to eat and workout regularly, but the weight just won't go away, well you may not be alone. There are many different medical conditions that limit your ability to lose weight, but thankfully science has now found how to use your brain to shed the weight.... Read more »
Dodd, G., Decherf, S., Loh, K., Simonds, S., Wiede, F., Balland, E., Merry, T., Münzberg, H., Zhang, Z., Kahn, B.... (2015) Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat. Cell, 160(1-2), 88-104. DOI: 10.1016/j.cell.2014.12.022
by Paul Whiteley in Questioning Answers
I have, on this blog, previously mentioned the paper by Alan Brown and colleagues [1] suggesting that: "The prevalence of maternal TPO-Ab+ [thyroid peroxidase antibody] was significantly increased in pregnancies giving rise to autism cases (6.15%) compared to controls (3.54%)." It was during some discussion on the suggested diagnosis of Down syndrome disintegrative disorder (see here) and the idea that some signs and symptoms of regressive autism (?) might overlap with TPO antibodies in some cases of Down syndrome.You've got a playdate with destiny!I've had a few weeks to further reflect on the Brown paper and decided that their suggestion of: "the first biomarker-based evidence that a class of known maternal autoimmune disorders is related to autism in offspring" is worthy of a post all of its own.A quick recap first: thyroid peroxidase antibodies translates as the body mounting an immune response against thyroid peroxidase, an important enzyme in the production of the thyroid hormones. As per another mention of TPO based on research suggestive of a tentative link between anti-TPO antibodies and [some] depressive disorder (see here), the more usual clinical occasion regarding detection of such antibodies is in relation to something like Hashimoto's thyroiditis, an autoimmune condition.Brown and colleagues drew upon collected data from the Finnish Prenatal Study of Autism (FiPS-A) [2], an initiative which had at its disposal "archived maternal serum specimens from virtually the entire pregnant population of Finland beginning in 1983". Alongside quite a bit of other registry based information on things like an ICD-10 diagnosis of autism in offspring, Brown et al set to work analysing those archived serum specimens for some "967 matched case-control pairs" (autism cases matched 1:1 with sex and date of birth linked asymptomatic controls) for the presence of thyroid peroxidase antibody (TPO-Ab).As per the previous sentence, serum samples from mums who went on to have a child with autism were significantly more likely to present with TPO-Ab; indeed: "The odds of autism were increased by nearly 80% among offspring of mothers who were TPO-Ab+ during pregnancy" compared with those antibody negative. Perhaps just as important, authors also reported that: "Measures of maternal thyroid hormones did not differ between groups" suggesting that the actual antibodies might be the more important factor over and above a thyroid hormone link (see here for discussion on other work in this area).For those who follow this blog, the idea that [some] autism and [some] autoimmunity / autoimmune conditions might show [some] linkage is not a new one. If one delves deeper into the peer-reviewed research arena one finds other hints that other maternal antibodies might also show a connection to offspring autism risk as per the idea of MAR autism (see here), that is, maternal autoantibody-related autism. Granted, the research road has not run entirely smoothly when it comes to any possible connection (see here) and there are still questions to be answered, not least when it comes to the effects of comorbidity common to autism and how they may likewise have an autoimmune connection too (see here for example). The Brown results however cannot be readily brushed under the scientific carpet given their origin and pretty powerful participant numbers used in the current study alongside some prior research 'form in the inflammatory area (see here). I for one, am keenly awaiting further investigations perhaps including a study or two on offspring autism risk among mothers with autoimmune thyroiditis [3]...?To close: California Über Alles. Let moshing commence...----------[1] Brown AS. et al. Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:86-92.[2] Lampi KM. et al. Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): overview and design. J Autism Dev Disord. 2011 Aug;41(8):1090-6.[3] Molloy CA. et al. Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA Study. J Autism Dev Disord. 2006 Apr;36(3):317-24.----------Brown, A., Surcel, H., Hinkka-Yli-Salomäki, S., Cheslack-Postava, K., Bao, Y., & Sourander, A. (2015). Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort Progress in Neuro-Psychopharmacology and Biological Psychiatry, 57, 86-92 DOI: 10.1016/j.pnpbp.2014.10.010... Read more »
Brown, A., Surcel, H., Hinkka-Yli-Salomäki, S., Cheslack-Postava, K., Bao, Y., & Sourander, A. (2015) Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 86-92. DOI: 10.1016/j.pnpbp.2014.10.010
by Dr. Jekyll in Lunatic Laboratories
More bad news for war Veterans, the brains of some Iraq and Afghanistan combat veterans who survived blasts from improvised explosive devices (IEDs) and died later of other causes show a distinctive honeycomb pattern of broken and swollen nerve fibers throughout critical brain regions, including those that control executive function. The pattern is different from brain damage caused by car crashes, drug overdoses or collision sports, and may be the never-before-reported signature of blast injuries suffered by soldiers as far back as World War I.... Read more »
Ryu J, Horkayne-Szakaly I, Xu L, Pletnikova O, Leri F, Eberhart C, Troncoso JC, & Koliatsos VE. (2014) The problem of axonal injury in the brains of veterans with histories of blast exposure. Acta neuropathologica communications, 2(1), 153. PMID: 25422066
by Paul Whiteley in Questioning Answers
For the past couple of years I've been tracking some rather interesting publications coming out of data from Jamaica on the topic of autism / autism spectrum disorder (ASD) specifically looking at the possible overlap between genes and various environmental factors. I thought now would be a good time to bring this collection of papers to the blogging table and summarise their findings based on the analysis of data collected from The Jamaican Autism study. The fact that their latest research foray mentions some of the genetics of glutathione [2] with autism in mind is very interesting in light of some other findings in this area (see here). There's more on this shortly.You're not Absolem. I'm Absolem. Stupid girl.So:Study 1: Maternal and paternal age are jointly associated with childhood autism in Jamaica [2].Higher parental age - both mother and father age - seemed to be associated with a diagnosis of autism/ASD in offspring. Higher maternal age in particular, survived further statistical analysis as being a potentially important factor. This is a topic which has cropped up in autism research circles before (see here).Study 2: Seafood consumption and blood mercury concentrations in Jamaican children with and without autism spectrum disorders [3]."Our findings do not support an association between blood mercury concentrations measured in Jamaican children 2–8 years of age and ASD case status." Such a conclusion was based on the analysis of blood mercury concentrations between ASD cases and a control group, and took into account important factors such as seafood consumption bearing in mind what is known about such a foodstuff and environmental exposures (see here).Study 3: The role of drinking water sources, consumption of vegetables and seafood in relation to blood arsenic concentrations of Jamaican children with and without Autism Spectrum Disorders [4].Blood arsenic levels were the focal point of this study, and a familiar conclusion to the previous study: "Our results do not support an association between postnatal total blood arsenic measured in Jamaican children 2-8 years of age and ASD case status." Again the consumption of certain foodstuffs seemed to be important correlates related to any elevated levels of arsenic detected.Study 4: Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder [5].Cadmium levels this time around, and again: "we did not find any significant differences between ASD cases and typically developing (TD) controls with respect to the 75th percentile of blood cadmium concentrations." Food (yes again) seemed to be a good correlate linked to differences in blood cadmium levels.Study 5: Blood manganese concentrations in Jamaican children with and without autism spectrum disorders [6].Manganese, and wait for it... "Our results do not indicate a relationship between postnatal BMC [blood manganese concentrations] and ASD case status of Jamaican children ages 2–8 years."Study 6: Blood Lead Concentrations in Jamaican Children with and without Autism Spectrum Disorder [7].Lead (Pb), a favourite topic of this blog, was the metal of choice when it came to analysis to see if there was any connection between the stuff and autism. Er,... "Our results do not support an association between postnatal blood lead concentration measured in Jamaican children 2–8 years of age and ASD case status."I think you can see the trend coming out of this data examining samples of children living in Jamaica with and without autism. Perhaps just as important are the various discussions about the ways and means that participants might have been exposed to these various metals and how one needs to be aware of how food in particular, could be a significant source of exposure. This perhaps puts a new slant on previous studies which have suggested an increased body burden of certain metals to be associated with autism (see here) and the question of whether dietary sources of such metals have adequately been taken into account. Don't get me wrong, I'm still very keen to see more 'metallomics' applied to autism research (see here), perhaps just controlling for a few more potentially important confounders.The Jamaican Autism study also provides quite a nice template for setting up further geographically distinct initiatives to compare and contrast with/against. I note for example that the recent study from Hodgson and colleagues [8] looking at autism in Oman (itself the topic of quite a few peer-reviewed publications) suggested some rather different results for their cohort: "Mercury levels were markedly elevated in the hair of autistic subjects vs. control subjects" albeit based on hair analysis not blood. With the previous caveat about confounders in operation, one wonders whether there may be more to see across different countries particular when bringing into play the potential importance of that glutathione connection which has also previously received some mention in the Jamaican autism studies [9].And then some music. Jamaica and music, mmm... One Love.----------[1] Rahbar MH. et al. nteraction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders. Research in Autism Spectrum Disorders. 2015; 12: 1-9.[2] Rahbar MH. et al. Maternal and paternal age are jointly associated with childhood autism in Jamaica. J Autism Dev Disord. 2012 Sep;42(9):1928-38.[3] Rahbar MH. et al. Seafood consumption and blood mercury concentrations in Jamaican children with and without autism spectrum disorders. Neurotox Res. 2013 Jan;23(1):22-38.[4] Rahbar MH. et al. The role of drinking water sources, consumption of vegetables and seafood in relation to blood arsenic concentrations of Jamaican children with and without Autism Spectrum Disorders. Sci Total Environ. 2012 Sep 1;433:362-70.[5] Rahbar MH. et al. Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder. Res Autism Spectr Disord. 2014 Sep 1;8(9):1134-1145.[6] Rahbar MH. et al. Blood manganese concentrations in Jamaican children with and without autism spectrum disorders. Environ Health. 2014 Aug 23;13:69.[7] Rahbar MH. et al. Blood Lead Concentrations in Jamaican Children with and without Autism Spectrum Disorder. Int J Environ Res Public Health. 2014 Dec 23;12(1):83-105.[8] Hodgson NW. et al. Decreased glutathione and elevated hair mercury levels are asso... Read more »
Rahbar MH, Samms-Vaughan M, Loveland KA, Pearson DA, Bressler J, Chen Z, Ardjomand-Hessabi M, Shakespeare-Pellington S, Grove ML, Beecher C.... (2012) Maternal and paternal age are jointly associated with childhood autism in Jamaica. Journal of autism and developmental disorders, 42(9), 1928-38. PMID: 22230961
by Dr. Jekyll in Lunatic Laboratories
As we've seen from research featured here at the lab, there are many genetic disorders that cause intellectual disability and autism. Historically, these were viewed as untreatable. However, in recent years we have shown via animal models that it is possible to reverse the effects of these gene mutations. But the question remained whether different gene mutations disrupt common physiological processes. If this were the case, a treatment developed for one genetic cause of autism and intellectual disability might be useful for many others.... Read more »
Tian, D., Stoppel, L., Heynen, A., Lindemann, L., Jaeschke, G., Mills, A., & Bear, M. (2015) Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion. Nature Neuroscience. DOI: 10.1038/nn.3911
by Paul Whiteley in Questioning Answers
Slow colonic transit is all about issues with the speed of gastrointestinal (GI) motility and how as well as deriving nourishment from our food/drink, the other important task which our gut undertakes is the removal of waste, which it generally does pretty well. The paper by Zainab Ridha and colleagues [1] suggested that a diagnosis of autism might be over-represented when it came to their review of children referred for "nuclear transit studies", that is measuring bowel transit by means of using a radiotracer. Indeed the authors note: "Neuropsychiatric disorders, in particular autism, are useful predictors of STC [slow transit constipation] and FFR [functional fecal retention] in children". I think we might have previously seen snippets of these results in another publication too [2].You might feel a sharp scratch...It's not new news that functional bowel disorders such as constipation and diarrhoea tend to be quite frequent issues accompanying quite a few cases of autism. I've covered some of the research on this topic before on this blog (see here). I might in particular, draw your attention to the meta-analysis by Barbara McElhanon and colleagues [3] (open-access) that concluded: "Children with ASD [autism spectrum disorder] experience significantly more general GI symptoms than comparison groups".Although there is now pretty widespread acceptance that bowel issues can and often do accompany autism, there is still a degree of reticence to talk about what might be causing such issues and what *might* be done about them [4], specifically when approached in the context of more serious underlying bowel disorders potentially being linked to said functional bowel issues (see here). I hark back to one of my first ramblings on this topic which was titled: 'Should I mention gastrointestinal symptoms in autism?' as an example of how delicate an area of investigation this was/is.I'd like to think that the paper from Ridha et al might however continue to open this research area up and highlight how the so-called gut-brain axis is growing in both acceptance and understanding. The additionally interesting data from the authors suggesting that: "15.8 % of patients with constipation were obese, compared to 6.4 % in the general Australian paediatric population" whilst not necessarily autism-exclusive might also stimulate further interest in light of the analysis of weight and activity with autism in mind too (see here). Oh, and that nutritional deficiency and a higher body mass index (BMI) might also be another curious combination for some on the autism spectrum [5].I'm going to chance my [speculating] luck and say that among the many factors potentially involved in these combined factors, a role for those trillions of wee beasties that call us home (the gut microbiome) might also show some involvement...Music: Joe Cocker - With A Little Help From My Friends (RIP).----------[1] Ridha Z. et al. Predictors of slow colonic transit in children. Pediatr Surg Int. 2014 Dec 31.[2] Croaker D. et al. PO-0110 Predictors Of Slow Colonic Transit In Children. Arch Dis Child 2014; 99: A285.[3] McElhanon BO. et al. Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis. Pediatrics. 2014 May;133(5):872-83.[4] Coccolrullo P. et al. Lactobacillus reuteri (DSM 17938) in Infants with Functional Chronic Constipation: A Double-Blind, Randomized, Placebo-Controlled Study. J Peds. 2010; 157: 598-602.[5] Shmaya Y. et al. Nutritional deficiencies and overweight prevalence among children with autism spectrum disorder. Res Dev Disabil. 2014 Dec 19;38C:1-6.----------Ridha Z, Quinn R, & Croaker GD (2014). Predictors of slow colonic transit in children. Pediatric surgery international PMID: 25549892... Read more »
Ridha Z, Quinn R, & Croaker GD. (2014) Predictors of slow colonic transit in children. Pediatric surgery international. PMID: 25549892
by Jonathan Trinastic in Goodnight Earth
The well-known global warming hiatus since 2000 has been partially explained by recent data from satellite measurements showing that sulfate emissions from volcanic eruptions is reflecting incoming sunlight.... Read more »
Santer, B., Solomon, S., Bonfils, C., Zelinka, M., Painter, J., Beltran, F., Fyfe, J., Johannesson, G., Mears, C., Ridley, D.... (2014) Observed multi-variable signals of late 20th and early 21st century volcanic activity. Geophysical Research Letters. DOI: 10.1002/2014GL062366
by Dr. Jekyll in Lunatic Laboratories
You really don't hear much about mass die-offs from mainstream news outlets; this might make you think they don't happen that often. However, an analysis of 727 mass die-offs of nearly 2,500 animal species from the past 70 years has found that such events are increasing among birds, fish, and marine invertebrates. At the same time, the number of individuals killed appears to be decreasing for reptiles and amphibians, and is unchanged for mammals.... Read more »
Samuel B. Fey, Adam M. Siepielski, Sébastien Nusslé, Kristina Cervantes-Yoshida, Jason L. Hwan, Eric R. Huber, Maxfield J. Fey, Alessandro Catenazzi, & Stephanie M. Carlson. (2015) Recent shifts in the occurrence, cause, and magnitude of animal mass mortality events. Proceedings of the National Academy of Sciences of the United States of America. info:/10.1073/pnas.1414894112
by Miss Behavior in The Scorpion and the Frog
We are all familiar with the concept of the personality of an individual. We are less familiar with group- or collective personalities (although most teachers can tell you at length about the personalities of each of their classes). The concept is the same: whereas an individual personality relates to an individual's consistent behaviors across time and contexts, a collective personality relates to a group's consistent behaviors across time and contexts. Collective personalities can be strongly influenced by the composition and size of the animal group, but also by the environment. A social spider web by Harvey Barrison at Wikimedia Commons. This week at Accumulating Glitches I talk about how the environment influences group personalities in social spiders. Check it out here. And to learn more, check this out: Modlmeier, A., Forrester, N., & Pruitt, J. (2014). Habitat structure helps guide the emergence of colony-level personality in social spiders Behavioral Ecology and Sociobiology, 68 (12), 1965-1972 DOI: 10.1007/s00265-014-1802-z ... Read more »
Modlmeier, A., Forrester, N., & Pruitt, J. (2014) Habitat structure helps guide the emergence of colony-level personality in social spiders. Behavioral Ecology and Sociobiology, 68(12), 1965-1972. DOI: 10.1007/s00265-014-1802-z
by Alexis Delanoir in How to Paint Your Panda
In a study entitled "The Effect of Police Body-Worn Cameras on Use of Force and Citizen's Complaints Against the Police: A Randomized Controlled Trial," published in the Journal of Quantitative Criminology, Ariel et al. review what is the first scientific report on the topic of whether or not police body-worn cameras work in terms of decreasing the rate of excessive force by police. As the title suggests, it also reviewed the effects of body-worn cameras on the rate of complaints raised by citizens against the police for excessive use of force.... Read more »
Ariel, B., Farrar, W., & Sutherland, A. (2014) The Effect of Police Body-Worn Cameras on Use of Force and Citizens' Complaints Against the Police: A Randomized Controlled Trial. Journal of Quantitative Criminology. DOI: 10.1007/s10940-014-9236-3
by Dr. Jekyll in Lunatic Laboratories
In the US and many Western countries, people are urged to manage feelings of anger or suffer its ill effects. We are raised to, for a large part, stifle our emotions and to "not be so angry." However, new research with participants from the US and Japan suggests that anger may actually be linked with better, not worse, health at least in certain cultures.... Read more »
Kitayama S., J. M. Boylan, Y. Miyamoto, C. S. Levine, H. R. Markus, M. Karasawa, C. L. Coe, N. Kawakami, G. D. Love, & C. D. Ryff. (2015) Expression of Anger and Ill Health in Two Cultures: An Examination of Inflammation and Cardiovascular Risk. Psychological Science. DOI: http://dx.doi.org/10.1177/0956797614561268
by Dr. Jekyll in Lunatic Laboratories
It was an infamous experiment, one on obedience and reprehensible behavior done in 1961. With memories of Holocaust atrocities and the prosecution of Nazi officials at Nuremberg still fresh, psychologist Stanley Milgram made history. You may not remember the name per say, but chances are you know his work.... Read more »
Hollander, M. (2015) The repertoire of resistance: Non-compliance with directives in Milgram's 'obedience' experiments. British Journal of Social Psychology. DOI: 10.1111/bjso.12099
by neurosci in Neuroscientifically Challenged
When the movie Lucy was released in the summer of 2014, it was quickly followed by a flurry of attention surrounding the idea that we only use 10% of our brains. According to this perspective, around 90% of our neurons lie dormant, all the while teasing us by reminding us that we have only achieved a small fraction of our human potential. In the movie, Scarlet Johansson plays a woman who takes an experimental new drug that makes her capable of using upwards of 90% of her brain. Due to this sudden enhancement in brain utilization, she develops unprecedented cognitive abilities, as well as some extrasensory capabilities like telepathy and telekinesis. Thus, the plot of the movie actually hinges on the accuracy of the 10% of the brain idea. Unfortunately, it is an idea that has at this point been thoroughly debunked. In truth, it appears that all of our brain is active fairly constantly. Although some areas may be more active at times than others, there are no areas that ever go completely dark.Despite this understanding of full-brain utilization being widely endorsed throughout the scientific community, the 10% of the brain myth is still accepted as true by a significant proportion of the public (which might explain why Lucy was able to rake in close to $460 million worldwide). In fact, a recent survey of educators in five different countries--the United Kingdom, The Netherlands, Turkey, Greece, and China--found that the percentage of teachers who believe in the 10% of the brain myth ranges from a low of 43% in Greece to a high of 59% in China.The same survey identified a number of other inaccurate beliefs about the brain held by educators--beliefs that have come to be categorized as neuromyths. For example, 44-62% of teachers believed that consuming sugary drinks and snacks would be likely to affect the attention level of their students. The idea that sugar intake can decrease children's attention and increase their hyperactivity has been around since the 1970s. The first formal study to identify a relationship between sugar and hyperactivity was published in 1980, but it was an observational study without the ability to make any determination of a causal relationship. Since then more than a dozen placebo-controlled studies have been conducted, but a relationship between sugar and hyperactivity has not been supported. In fact, some studies found sugar to be associated with decreased activity. Yet, if you spend an afternoon at a toddler's birthday party, your chances of overhearing a parent attributing erratic toddler behavior to cake are around 93% (okay, that's a made-up statistic but the chances are high).According to the survey, a large percentage (ranging from 71% in China to 91% in the U.K.) of teachers in the countries mentioned above also believe that hemispheric dominance is an important factor in determining individual differences in learning styles. In other words, they believe that some people think more with their "left brain" and others more with their "right brain," and that this lateralization of brain function is reflected in personalities and learning styles. The concept of hemispheric dominance has been an oft-discussed one in neuroscience since the 1860s when Paul Pierre Broca identified a dominant role for the left hemisphere (in most individuals) in language. Since the middle of the twentieth century, however, the concept of hemispheric dominance has been extrapolated to a number of functions other than language. Many now associate the right side of the brain with creativity and intuitive thinking, while the left side of the brain is linked to analytical and logical thought. By extension, people who are creative are sometimes said to be more "right-brained," while those who are more analytical are said to be "left-brained."These broad characterizations of individuals using one side of their brain more than the other, however, are not supported by research. Although there are certain behaviors that seem to rely more on one hemisphere than the other--language and the left hemisphere being the best example--overall the brain functions as a whole and in general an individual doesn't preferentially use one hemisphere more based on his personality. Still, this myth has become so pervasive that a recommendation that children be identified as right-brained or left-brained and teaching approaches be modified accordingly has even made its way into educational texts.Where do neuromyths come from?Neuromyths are not generally created nor spread with malicious intent. Although there may be instances where inaccurate neuroscience information is used by entrepreneurs hoping to convince the public of the viability of a dubious product, usually neuromyths arise out of some genuine scientific confusion. For example, the misconception that sugar causes hyperactivity in children was bolstered by a study that did detect such an effect. The scientific status of the hypothesis, however, was forced to remain in limbo for a decade until more studies could be conducted. Those subsequent, better-designed studies failed to find a relationship, but by that time the myth had taken on a life of its own. The fact that it was so easy for parents to mistakenly attribute poor behavior to a previous sugary treat helped to sustain and propagate the inaccuracy.So, some neuromyths are born from a published scientific finding that identifies a potential relationship and grow simply because it then takes time--during which faulty information can spread--to verify such a finding. Many myths also arise, however, from inherent biases--both personal and cultural--or the misinterpretation of data. At times, the sheer complexity of the field of neuroscience may be a contributing factor, as it may cause people to seek out overly simplistic explanations of how the brain works. These oversimplifications can be alluring because they are easy to understand, even if at times they are not fully accurate. For example, the explanation of depression--a disorder with a complex, and still not understood etiology--as being attributable to an imbalance of one neurotransmitter (i.e. serotonin) was popular in scientific and public discourse for decades before being recognized as too simplistic. After the scientific community has untangled any confusion that may have led to the creation of a neuromyth, it still takes quite a long time for the myth to die out. In part, this is because there is a disconnect between the information that is readily available to the public and that which is accessible to the scientific community. Most of the general public do not read academic journals. So, if several studies that serve to debunk a neuromyth are published over the course of a few years, the public may be unaware of these recent developments until the findings are communicated to them in some other form (e.g. a website or magazine that has articles on popular science topics).Eventually this knowledge does find its way into the public discourse, though, it's just a question of when. The 10% of the brain myth, for example, has probably lasted for at least a century. But by 2014 enough of the non-scientific community was aware of the inaccuracies in the plot of Lucy to raise something of an uproar about them. There are other neuromyths, however, that have more recently become part of public knowledge, and thus we are likely to see them come up again and again over the next several years before widespread appreciation of their erroneousness emerges.The myth of three, a current neuromythOne example of a (relatively) recently espoused neuromyth is sometimes referred to as the "myth of three." The underlying idea of the myth of three is that there is a critical period between birth and three years of age, during which most of the major events of early brain development occur. This is a time when there is extensive synaptogenesis--a term for the formation of new connections between neurons--occurring. According to the myth of three, if the external environment during this time isn't conducive to learning or healthy brain development, the effects can range from a missed--and potentially lost--opportunity for cognitive growth to irreversible damage. Conversely, by enriching a child's environment during these first three years, you can increase the chances he will grow up to be the next Doogie Howser, MD. In other words, ages 0 to 3 represent the most important years of a child's learning life and essentially determine the course for his or her future cognitive maturation. Hillary Clinton summarized the myth of three appropri... Read more »
Howard-Jones, P. (2014) Neuroscience and education: myths and messages. Nature Reviews Neuroscience, 15(12), 817-824. DOI: 10.1038/nrn3817
by Dr. Jekyll in Lunatic Laboratories
Your brain is a memory powerhouse, constantly recording experiences in long-term memory. Those memories help you find your way through the world: Who works the counter each morning at your favorite coffee shop? How do you turn on the headlights of your car? What color is your best friend's house? But then your barista leaves for law school, you finally buy a new car and your buddy spends the summer with a paint brush in hand. Suddenly, your memories are out of date. So what do you do, forget about it.... Read more »
Kim G, Lewis-Peacock JA, Norman KA, & Turk-Browne NB. (2014) Pruning of memories by context-based prediction error. Proceedings of the National Academy of Sciences of the United States of America, 111(24), 8997-9002. PMID: 24889631
by Dr. Jekyll in Lunatic Laboratories
In today's society, when it is so easy to over medicate children and adults alike it is nice to finally read something that looks for an alternative option. This particular case deals with pain management in children post surgery and the study shows that pediatric patients who listened to 30 minutes of songs by Rihanna, Taylor Swift and other singers of their choosing — or audio books — had a significant reduction in pain after major surgery.... Read more »
Sunitha Suresh B. S., & Santhanam Suresh. (2015) The effect of audio therapy to treat postoperative pain in children undergoing major surgery: a randomized controlled trial. Pediatric Surgery International. DOI: http://dx.doi.org/10.1007/s00383-014-3649-9
by Paul Whiteley in Questioning Answers
"The findings show that ADS [abdominal discomfort syndrome] is a characteristic of a subset of patients with ME/CFS [Myalgic Encephalomyelitis / Chronic Fatigue Syndrome] and that increased bacterial translocation (leaky gut) is associated with ADS symptoms."Right there. God does not build in straight lines.So said the study by Michael Maes and colleagues [1] looking at both gastrointestinal (GI) symptom presentation in diagnosed cases of ME/CFS and "the IgA and IgM responses directed against commensal bacteria" - rough translation: an immune system response against some of those microscopic beasties that call us home (residing in our deepest, darkest recesses). Leaky gut by the way, is something that I'm particularly interested in on this blog for quite a few different reasons (see here) and refers to potential issues with the barrier separating the contents of our GI tract from the wider body and the ever-vigilant immune system. Dysfunction of said barrier might mean that an immune response against bacteria are more likely as per a certain Sutterella finding in autism research a few years back. And before you ask, yes, leaky gut is a real concept despite some who would say otherwise...The term 'abdominal discomfort syndrome' akin, I think, to something around irritable bowel syndrome based on the results of the cluster analysis "performed on gastro-intestinal symptoms" by Maes et al, is an interesting finding. It is not necessarily new news that there may be sub-groups of people described under the label of ME/CFS, one of which might be a 'gut related subgroup' (see here). Indeed, gut inflammation has been mentioned on more than one occasion [2] with something of a connection to the presentation of more functional bowel issues.What is perhaps novel about the Maes findings is the authors' assertion that their study results point to: "a pathway phenotype, i.e bacterial translocation, that is related to ME/CFS and ADS/IBS and that may drive systemic inflammatory processes." This comes on the back of other evidence suggesting that issues with gut permeability associated with the process of bacterial translocation may be present in cases of ME/CFS and potentially amenable to intervention [3] (although I hasten to add that further research is required on this topic).Michael Maes is quite a prolific peer-reviewed author when it comes to ME/CFS tapping into some really, really interesting areas of research such as mitochondrial dysfunction [4], oxidative stress [5] and autoimmunity [6]. This latest research venture adds further to the notion that genetics and biology are the drivers of quite a large proportion of cases covered under the umbrella term 'overlapping fatigue syndromes' [7].And then some music. How about Yellow from Coldplay?----------[1] Maes M. et al. Evidence for the existence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome. Neuro Endocrinol Lett. 2014 Nov 2;35(6):445-453.[2] Lakhan SE. & Kirchgessner A. Gut inflammation in chronic fatigue syndrome. Nutr Metab (Lond). 2010 Oct 12;7:79.[3] Maes M. et al. Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome. Neuro Endocrinol Lett. 2007 Dec;28(6):739-44.[4] Morris G. & Maes M. Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways. Metab Brain Dis. 2014 Mar;29(1):19-36.[5] Morris G. & Maes M. Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS). Curr Neuropharmacol. 2014 Mar;12(2):168-85.[6] Morris G. et al. The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs). Mol Neurobiol. 2014 Apr;49(2):741-56.[7] Whiteley P. et al. Correlates of Overlapping Fatigue Syndromes. Journal of Nutritional and Environmental Medicine. 2014; 14: 247-259.----------Maes M, Leunis JC, Geffard M, & Berk M (2014). Evidence for the existence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome. Neuro endocrinology letters, 35 (6), 445-453 PMID: 25433843... Read more »
Maes M, Leunis JC, Geffard M, & Berk M. (2014) Evidence for the existence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome. Neuro endocrinology letters, 35(6), 445-453. PMID: 25433843
by Dr. Jekyll in Lunatic Laboratories
Antibiotic resistance, a hot topic lately here at the labs, as evidence by this recent post. So it is fortuitous that I stumbled upon this little bit of research that suggests scientists (using a "revolutionary" approach) have devised an antibiotic that may offset the mounting problem of drug resistance for decades… hopefully.... Read more »
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S.... (2015) A new antibiotic kills pathogens without detectable resistance. Nature. PMID: 25561178
by Paul Whiteley in Questioning Answers
It has been quite a few weeks since the publication of the paper by Simone Gupta and colleagues [1] (open-access) talking about "observations [that] provide pathways and candidate genes that highlight the interplay between innate immunity and neuronal activity in the aetiology of autism."I'm a wrecker. I wreck things, professionally. I mean.At the time of publication in early December (2014), there was quite a bit of media interest in the findings as per reports such as this one and this one. The watch-words were 'inflammation', 'brain' and 'immune response' as per the discovery that microglia - the constant gardeners - might play quite an important role in the process of inflammation or at least "implicating dysregulated microglial responses in concert with altered neuronal activity-dependent genes in autism brains."The Gupta paper is open-access so no need for the long explanation from me. Still a few points are worth mentioning bearing in mind my novice status in this area:The name of the game was transcriptomics, yet another -omic to add to your growing -omic dictionary, this time looking at "the complete set of RNA transcripts that are produced by the genome, under specific circumstances or in a specific cell."Said method was applied to RNA sequencing in "autism brains" or at least specific parts of the brain donated by families of 32 deceased people with autism and 40 asymptomatic controls. If you are really interested, cortical samples were analysed looking at some regions already discussed in the autism research literature (see here). I apologise for the cold, scientific discussions by the way given first and foremost those brain samples were very precious offerings.Differences in genetic expression were found between the groups which were further examined via gene ontology (GO!) and something called "weighted gene correlation network analysis" which as the name suggests looks at correlating genes which are co-expressed "to identify discrete gene modules based on co-expression between genes." One of the best hits the authors got was in relation to "enrichment for M2-microglial cell states... and the GO term 'Type I Interferon pathway'". The type I Interferon pathway includes the name 'interferon' which implicates immune function (see here).Ergo, "evidence for type I interferon and M2-activation state abnormalities in autism that may lead to a variety of pathologic and phenotypic consequences." The authors speculate that "M2-activation state microglia genes" are potentially 'driven' by the interferon response which brings us back to those headlines about brain inflammation being 'common' in autism. The idea that neuronal activity-dependent genes might also be 'affected' by this state unites immune function and brain development with at least the cohort of cases of autism in mind. I might also add that whilst interest focused on the microglia - interferon connection, the GO category enrichment data also picked up a few other potentially interesting connections including "defense response to virus" and "response to virus". Indeed, the authors summarised by suggesting: "These data provide support for a mechanistic connection for viral-infection hypotheses... for autism with neural over-growth hypotheses... through the novel identification of exaggerated M2 activation states in autism brain tissue." Parts of Johns Hopkins, where quite a few of the authors are based, have some speciality in this area as per other research teams (see here) so are perhaps ideally placed to follow this work up as and when required.Accepting that studying brains from the deceased is still an area fraught with some methodological issues not least because the diagnosis of autism very rarely exists in clinical isolation some comorbidity of which can impact on the reasons for early mortality, inflammation and autism already has quite a bit of research history when it comes to the peer-reviewed arena. The genetics of the immune system being implicated in autism is also not new news as per other entries on this blog (see here) and my already linking to some discussions about the Nardone paper [2] last year (2014) also implicating epigenetic processes too. Microglia and autism? Well again, been there and seen that similarly applies (see here).Interestingly, in some of the accompanying press attached to the Gupta study is the suggestion that future work might look to "find out whether treating the inflammation could ameliorate symptoms of autism." Approaching such a sentiment with some degree of caution, I'd be minded to suggest that such ideas seem to follow a pattern in psychiatry these days (see here) further to the idea that the chemistry of inflammation seems to be connected to at least some autism [3] (see here and see here too). Peter over at the Epiphany blog has, as well as covering the Gupta study, talked about quite a few ways and means that one might go about 'treating' such inflammation. What I would perhaps add - alongside my caveat about this blog not giving medical or clinical advice - is that rather than just focusing on the agents potentially 'causing' inflammation, one might also look at the counter-balance systems also present, as per my discussions on some fairly recent work from Harumi Jyonouchi and colleagues [4] and the so-called anti-inflammatory cytokines such as IL-10 (see here). Just a thought...The Blue Danube to close... (music starts at 1min 40secs)----------[1] ... Read more »
Gupta S, Ellis SE, Ashar FN, Moes A, Bader JS, Zhan J, West AB, & Arking DE. (2014) Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nature communications, 5748. PMID: 25494366
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Delaware's The News Journal reports that the bankruptcy of the Wilmington, Del., diocese -- brought on by a law suit over sex abuse by clergy -- is threatening the pensions of some 2,000 lay employees of the diocese, including teachers, cafeteria workers, housekeepers and maintenance workers.
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Town Square
Avoiding blood-sucking insects
Original post made on Jul 25, 2012
Read the full story here Web Link posted Wednesday, July 25, 2012, 11:02 AM
Comments (1)
a resident of Whisman Station
on Jul 25, 2012 at 4:45 pm
The real advice you need to give out is about how to avoid the average LAWYER, GOVERNMENT OFFICIAL or POLITICIAN.
They suck ( more blood ) more often than your average mosquito.
Up in the Upper Midwest, we had to use baseball bats to deal with them.
Your average bug zapper trays had to be emptied out every day...
PS: your verifier has a filthy mouth: iHoi2X is very rude.
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Cleveland, OHUSA
Hometown: Euclid, OH
April 23, 2012
Addicted to all things locks: picking, NDE, re/pinning, re/keying, physical and electronic security measures. Live in Cleveland, but occasionally visit Columbus to visit family. Working on re/starting Cleveland Locksport organization ASAP. :D
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Butch Jones After Another Tennessee Loss: "I Expect More Out Of Our Program"
Butch Jones has had an up-and-down season so far in his first year as head coach at Tennessee. Most Volunteers fans will agree he has the team headed in the right direction — the team is two-thirds of the way through the self-proclaimed "hardest schedule in the history of college football", and has stayed competitive in numerous games against some very tough opponents.
Tonight's 31-3 defeat at the hands of Missouri was a disappointing one, however, and Jones expects more of the team as it continues to strive for a place in postseason play:
JONES: We have to go back and get better. I expect more out of our program.
— Tennessee Football (@Vol_Football) November 3, 2013
JONES: Our goal as a football program is to get to a bowl game. Our expectation is to win every game. We need to keep working and believing.
— Tennessee Football (@Vol_Football) November 3, 2013
The schedule doesn't get any easier for Tennessee, as the Vols host the Auburn Tigers at Neyland Stadium next weekend.
Read More At Bleacher Report
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Thomas Duffy - Wednesday, July 29, 2015 11:19 pm


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U.S. Sen. John McCain (R-AZ) introduced a bill that would provide regulatory relief to video service providers who agree to unbundle and sell individual pay television channels to subscribers. In exchange for offering channels to consumers on an a la carte basis, video service providers would: receive the right to obtain a national franchise; pay lower fees to municipalities for the use of public rights of way; benefit from a streamlined definition of "gross video revenue" for the calculation of such fees; and prohibit the solicitation of institutional networks and in-kind donations. Called the Consumers Having Options in Cable Entertainment (CHOICE) Act of 2006, the bill is designed to grant significant regulatory relief to video service providers who agree to both offer cable channels on an a la carte basis to subscribers and not prohibit any channel owned by the video service provider from being sold individually. Broadcasters with an ownership stake in a cable channel would get the benefit of the FCC's network non-duplication rule if the broadcaster does not prohibit the channel from being sold individually. The bill also would extend Section 616(a) of the Communications Act to extend this provision to distribution over the Internet. McCain emphasized that his proposal is not a mandate on cable providers. "Instead it is designed to encourage choice and competition by granting significant regulatory relief to video service providers, such as telephone and cable companies, that agree to both offer cable channels on an a la carte basis to subscribers and to not prohibit any channel owned by the video service provider from being sold individually." The senator said his bill does not force video service providers or broadcasters "to do a single thing." He said it is their choice whether to act or not act. The bill, he insisted, is "incentive-based legislation that would encourage owners of cable channels to make channels available for individual purchase and would do nothing to prevent cable companies from continuing to offer a bundle of channels or tiers of channels."
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Florence + The Machine Video Releases Epic Double Feature Video:"Queen of Peace/Long & Lost"
The Perfect Blendship: Artist Designs Billboards to Vanish Into the Scenery
The Straight 'Dope' From Cinematographer Rachel Morrison


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As long as we're discussing alternate history, if ND gets to keep the early TD, then I say Matthews looks around for the ball and makes the catch, and U-M scores on that drive. (I.e., no ND INT followed by their score.)
Mike Spath points out that doing an interview for the official site is a pretty good indicator he'll be back.


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Why Should You Share Other People's Facebook Content?
9 Things You Need to Immediately Stop Doing on Facebook
Pew Study: Majority of Parents Rely on Social Media for Parenting Advice (Especially Mothers)
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tips and tools
6 Tips for Successful Marketing Automation
May 16, 2015
I've been talking to more companies and fellow marketers about email marketing automation this year than I ever have before. I wanted to write a post about what you should be thinking about before you ever get to choosing the actual platform and set of tools that can help you get to the level with your marketing.
The Dos And Don'ts Of Using Social Media For Business [INFOGRAPHIC]
March 08, 2015
So you've heard all about the importance of leveraging social media to grow your small enterprise. You realize that it can help you find new clients and engage existing customers. But actually doing marketing on sites like Facebook, Twitter, and Google+ is a whole other story. Wouldn't it be cool to have a little pocket guide to navigating the landscape of social media?
3 Inbound Marketing Insights You Need to Know
November 22, 2014
Inbound marketing, on the level it's done today, just wasn't possible prior to the digital age. Technology was the key limitation. Advertising on TV, or in your local newspaper, for that matter, had to paint in broad strokes. You could look at demographics and do your best to plan, but ultimately you had no way to connect with customers individually.
Social Marketing Tips To Survive The Ever-Changing Facebook Algorithm
September 28, 2014
While it's clear that social media is here to stay, that doesn't change the fact that individual sites are continuously changing everything from design elements to their core functionality.
3 Steps to Strengthen Your Voice for Social Media
September 21, 2014
When your brand begins engaging in social media, your voice needs to be strongly defined for the variety and volume of conversation you are now involved in.
10 Customer Service Tips for Businesses Leveraging Social Media
September 21, 2014
Customer service has rapidly progressed on social media. Gone are those days when your customers would write a letter or pick up the phone.
Content Marketing: 3 Things To Remember
September 14, 2014
Content marketing is on everybody's radar, right? Well, if it isn't, it should be–if you are interested in internet marketing at all.
How to Write a Blog Post in 10 Simple Steps
September 13, 2014
Writing blog posts used to be one of my most dreaded tasks, but recently I am dreading it less, sometimes I actually like it!
5 Ways Content Marketing is the New Community Marketing
September 06, 2014
Thinking of your Content Marketing program with a Community Marketing hat on is a great way to craft a program that spurs engagement.
15 Easy Ways To Come Up With Powerful Blog Topics
July 28, 2014
The other day I was on the phone with my friend Betty Marton. Betty is a professional writer. I've been teaching a course on blogging and she wanted to know how I help my students come up with topics for their blogs.


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Affittacamere "da Vasco", Cinque Terre - La Spezia area
- Free breakfast and free WiFi
Main amenities
- 2 guestrooms
- Self parking
- Air conditioning
What's around
- Lerici Beach (0.7 mi / 1.2 km)
- Golf Club Marigola (1 mi / 1.6 km)
Enter dates to check prices
Hotel Info: 866-266-9798from $140 CAD
- Double Room
- Triple Room
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 2 rooms
- This hotel is arranged over 2 floors
- Check-in time 2 PM-1:00 AM
- Check-out time is 10:30 AM
Required at check in
- Cash deposit required
- Government-issued photo ID required
Travelling with others
Extra people
- Roll-away beds available, charges may apply*
- Free WiFi in rooms
- Self parking *
Nearby Two Star Cinque Terre - La Spezia area hotels
In the hotel
- Free breakfast daily
- Golfing nearby
- Number of buildings/towers - 1
- Year Built 1950
In the room
- Air conditioning
- Coffee/tea maker
- Shower only
- Hair dryer
- Free WiFi
- Refrigerator
Top Cinque Terre - La Spezia area hotels
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Affittacamere "da Vasco", Cinque Terre - La Spezia area's small print
Cash transactions at this property cannot exceed EUR 999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation.
This property does not have elevators.
Optional extras
Self parking costs EUR 10 per day
Parking is available nearby and costs EUR 5 per 24 hours
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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Analysis: If you will it
Kahlon presents ministers with Arrangements Bill
Netanyahu: Justice will be dealt to Jerusalem gay pride parade attacker
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Recipes: Time for lime
July 31: Top 10 things to do
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Hasarma to make Arab history on sidelines
Kroyter jumps back into picture as high-flying Israeli phenom
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Journalists to appeal to High Court against IBA shutdown
Hotovely: Netanyahu government will back more settlement building
Terrorist fires at Israeli car near Kochav Hashahar; Israeli driver fires back
Hamas: 'Every Israeli is now a legitimate target' following Duma terror attack
Erekat calls on international community to protect Palestinians from Israelis after toddler killed
Ya'alon: We will not allow Jewish terrorists to harm Palestinians
Palestinian baby killed in West Bank terror attack
Ex-hasid who committed suicide had mental issues, says family
Survivors appeal to Pope to intercede with Germany over Holocaust reparations
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Iraqi militia leader says US not serious about fighting Islamic State
Canadian-Israeli anti-ISIS fighter: If we don't fight them there, they'll come here
My friends went on vacation and all I got was this stupid ISIS flag
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Welcoming new immigrants to Israel
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Beware Ottoman land law!
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01/03/2013 21:18
President Shimon Peres 521.
(photo credit:Marc Israel Sellem)
If we put aside the timing (three weeks before the elections) and the identity
of the speaker (President Shimon Peres), we are left only with the content of
the claim: "It is possible to reach a peace agreement with PA President Mahmoud
Abbas."If such is the case, perhaps, Mr. President, you can
explain why there isn't already a signed peace deal? At Camp David in 2000,
Yasser Arafat rejected prime minister Ehud Barak's peace offer.US
president Bill Clinton blamed Arafat for the failure of the talks, and just
recently his merry widow, Suha, has admitted what was already known: Arafat
planned the wave of terrorism that followed Camp David.Okay, the naive
will say, but that was Arafat, the terrorist chief with a shameful reputation;
now we have Abbas.Well, what happened between Abbas and prime minister
Ehud Olmert at the Annapolis negotiations in 2007? In a recent interview with
Smadar Perry – a reporter for Yediot Aharonot – Abbas claimed that Israel and
the Palestinians were on the verge of signing an agreement, and it was only the
early elections called in Israel that prevented the long-yearned-for signing of
peace accords.I am trying to find a civilized way to express myself
while being faithful to the facts of the matter, but there is no other way to
say it: Abbas is lying.The talks took place in November 2007, Ehud
Olmert resigned almost a year later, and the elections were held in 2009. A
peace agreement was not agreed to because Abbas turned down Olmert's exceedingly
generous offer.However, Prime Minister Binyamin Netanyahu cannot make
the same offers made by Barak and Olmert. They both proposed more than the
Israeli public is ready to accept, and more than Israel can allow itself to
concede. Abbas rejected Olmert's offer, so there is no way he can strike a peace
deal with Netanyahu.It's simple and certain. Every attempt to sit down
and reach agreement on the issues under dispute – Jerusalem, refugees, borders,
etc. – has failed, time after time.President Peres can make endless
speeches about nanotechnology, embrace Mark Zuckerberg, and appear to be
innovative and expansive in his views, but his proposal to resolve the conflict
with the Palestinians is tantamount to suggesting that we return to using the
Zeppelin airships again.The Zeppelins were not that successful back
then, and one even exploded. Exactly like Peres's solutions for accommodating
the Palestinians.The whole idea, to manage to make a pact with Abbas
quickly, before Hamas takes over the West Bank, is ridiculous. Abbas doesn't
have the courage to reach an agreement, and he has no legitimacy with his own
people.The Palestinian public is not prepared to accept concessions by
its leaders, something that is necessary for successful
negotiations.Each side has to make concessions.We need time and
calm. Both sides can be creative – the Palestinians can establish a state in the
so-called Area A (Palestinian-controlled territory) and not give up on their
dreams.The Palestinians can dream about the refugees returning, and the
Western Wall, and anything they else they want to.And we will stay where
we are, life will continue, and 20 years will pass. In the meantime, perhaps the
shaky regime in Jordan will fall and the Palestinians can have a really big
state – the whole of Jordan and Area A – and everyone will be happy.Even
the king and his family might feel safer and have a stronger sense of belonging
in their home in London.Let the Palestinians prove that their goal is a
state for their own people, rather than what it appears to be now: The
destruction of Israel.Gilad Sharon, son of former prime minister Ariel
Sharon, is author of Sharon: The Life of a Leader.
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Hewlett-Packard College Finance Intern Interview Questions
Interview Experience
Interview Experience
Getting an Interview
Getting an Interview
Interview Difficulty
Interviews for Top Jobs at Hewlett-Packard
- Software Engineer (150)
- Business Analyst (62)
- Intern (50)
- Project Manager (49)
- Senior Software Engineer (46)
- Software Developer (39)
- Financial Analyst (35)
- Technical Consultant (34)
- Technology Consultant (32)
- Technical Support Engineer (29)
- Inside Sales Representative (28)
- Engineering (22)
- Program Manager (21)
- Sales Representative (19)
- Solutions Architect (17)
- Engineer (17)
- Systems/Software Engineer (15)
- Account Manager (15)
- Marketing Manager (14)
- IT Developer/Engineer (13)
- Systems Engineer (13)
- Process Associate (13)
- Manager (13)
- Hardware Engineer (12)
- IT Project Manager (12)
- Mechanical Engineer (11)
- Consultant (11)
- Product Manager (10)
- Analyst (10)
- Sales Manager (9)
1 Candidate Interview Review Back to all InterviewsSort: Popular Date Difficulty
College Finance Intern Interview
I applied through college or university. The process took 3+ months – interviewed at Hewlett-Packard (Cupertino, CA) in December 2010.
One of the VPs of the Department I work in from another city came to my school and interviewed students based off of the resume's he recived. It was a hour long behavioral interview in a 1-on-1 office on campus. I then didn't hear anything for about 3 weeks (in terms of the process), but was kept in touch with to tell them they were still thinking of me. I then was told that I would be video conference interviewed by the CFO of the Department I would work with. I didn't hear from them for a month (their fiscal year ended), and was then contacted by a different member (manager) of the department. I then had an hour long phone Interview (the job site is out of my state).
Interview Questions
- Very Basic Behavioral questions, Just further indepth that tipical Answer Question
Due to the offer being extended very close to the start date, there was no time to negotiate. Also, internship jobs are usually offered at a fix salary level with very little wiggle room.


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Christmas Day 2010
Strawberry Jump
King Of Shapes
Hardball Frenzy
Grandma's Kitchen 6
Sarah Princess Dressup
Gothic Lolita Fashion
Crazy Craft
Pic Tart - Superman
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It's Gonna Blow
Sarah's Pub Life
New Fashion Trends For Gi...
Tiles Builder - The Spiderman
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There are 30 1 player games14 games on Girl Games. We have chosen the best 1 player games14 games which you can play online for free. All these games can be played online directly, without signup or download required, but if you prefer to play games offline, you can also download any game file to your PC. 1 player games14 games on this page are sorted according to users' rating, a game with the highest score is listed at first, so it's easy to find a good 1 player games14 games on Girl Games site. We also add new games daily to ensure that you won't get bored of playing old games again and again. Enjoy!


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(By Balaseshan) Hasbro Inc. (NASDAQ: HAS), which provides children's and family leisure time products and services, expects fourth quarter revenue below consensus as consumer demand through much of the holiday season was less than anticipated, sending its shares down 4.55% in premarket.
The company expects to incur charges of about $37 million pre-tax in 2012, and an additional estimated $20-$30 million in 2013 associated with these planned actions to reduce ongoing expenses, including an approximate 10% reduction in workforce, facility consolidation and process improvements.
These actions are anticipated to begin to deliver savings in 2013, with full recognition in 2015 as all aspects of the plan are implemented.
[Related -Hasbro, Inc (HAS): Things You Should Know Before Investing In Hasbro]
The company projects revenue for the fourth quarter to be about $1.28 billion, including a negative $8 million impact from foreign exchange, compared to $1.33 billion in 2011. Street analysts predict revenue of $1.40 billion.
"We had a number of strong product initiatives, but consumer demand through much of the holiday season was less than anticipated in both the U. S. and certain international markets. As a result, fourth quarter revenues did not meet our expectations," said Brian Goldner, Chief Executive of Hasbro.
"Despite the lower than anticipated revenue, we grew our operating profit margin and earnings per share absent fourth quarter restructuring charges and the impact of foreign exchange," Goldner added.
[Related -Hasbro, Inc. (HAS): On The Cusp Of A New Chapter]
For the full year 2012, the company expects to report revenue of about $4.09 billion, compared to $4.29 billion in 2011. Absent a $99 million negative impact from foreign exchange, full year revenue declined 2%. Street predicts $4.21 billion revenue.
Based on preliminary full-year results, Hasbro expects full year 2012 earnings per share, excluding fourth quarter restructuring charges and unfavorable impact of foreign exchange, of $2.83 to $2.85, while Street predicts $2.85. Earnings forecast includes $11.1 million or $0.06 per share of severance costs recorded in the first quarter 2012.
HAS closed Thursday's regular session at $38.45. The stock has been trading between $32 and $39.98 for the past 52 weeks.
My inner trader uses the trading model component of the Trend Model seeks to answer the question, "Is the read on...
US economic growth rebounded in the second quarter, but the Treasury market isn't convinced that GDP's 2.3% read on...
When a company stumbles repeatedly, investors eventually throw in the towel and sell their shares. read on...
I'm not going to argue for any particular strategy here. My main point is this: every valid strategy is read on...


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Courtney B. Vance
A graduate of Harvard University and Yale School of Drama, Angela Bassett's hubby was one of the foremost Black actors in Hollywood when he signed on for Dangerous Minds. After an acclaimed performance as the school principal, Vance hasn't slowed down a bit. Vance's career spans film, television and Broadway. He starred on Law & Order for six seasons, in acclaimed films like Hurricane Season and Cookie's Fortune and earned a Tony for his stage performance in 2013's Lucky Guy.
(Photo: Hollywood Pictures)
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Rise Up: Celebrity Protesters07/07/2015
Who's Your Daddy? Celebrity Paternity Lawsuits07/06/2015
Quotes: Meek Mill Says Being With Nicki Minaj Is a Dream07/03/2015
Out and About: Tracy Morgan Celebrates at Disney World07/02/2015
Cinemania: Must-See Movies in July07/02/2015
Celebrity Birthdays: Missy Elliott Celebrates!07/01/2015
You Gotta Have It: What to Hear, See and Cop This Month06/30/2015
Where Are They Now? The Cast of Coming to America06/29/2015
Quotes: Obama Speaks on Historic Marriage Equality Ruling06/26/2015