text:
18.4 cu. ft. Food Service Grade Refrigerator with 4 Adjustable Full-Width Wire Shelves, Fluorescent Interior Lighting, Casters, Mechanical Temperature Dial and Frost-Free Defrost System
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14.5 cu. ft. Beverage Merchandiser with Adjustable Wire Shelves, Automatic Defrost, Recessed LED Lighting, Door Lock, Digital Thermostat and Digital Display
11.0 cu. ft. Beverage Merchandiser with Adjustable Chrome Shelves, Automatic Defrost, Door Alarm, Recessed LED Lighting, Door Lock and Stainless Steel Interior
24" Built-in Beverage Center with 5.4 cu. ft. Capacity, 85 12-oz. Bottle Capacity, 105 12-oz. Can Capacity, 16 Wine Bottle Capacity, Interior Lighting and Reversible Door Swing
11.0 cu. ft. Beverage Merchandiser with Adjustable Wire Shelves, Automatic Defrost, Fluorescent Lighting, Keyed Lock, Digital Thermostat and Thin-Line Design
48" Built-in Side by Side Refrigerator with 3 Adjustable Spill-Proof Glass Shelves, Dual Refrigeration System, Refrigerator/Freezer Drawers, Ice Maker, Auto-Close Hinge System, Glass Door and Star-K Certified
36" Built-in All-Refrigerator with 24.2 cu. ft. Capacity, Stainless Steel Framed Glass Shelves, Storage Bins, Clear Crispers and Stainless Steel Interior
13.0 cu. ft. Beverage Center with Adjustable Wire Shelves, Automatic Defrost, Fluorescent Lighting, Door Lock, Thin-Line Design and Commercially Approved
30" Built-in Bottom-Freezer Refrigerator with 3 Adjustable Spill-Proof Glass Shelves, Humidity-Controlled Drawer, 1 Storage Drawer, Ice Maker, Glass Door and Star-K Certified
9.0 cu. ft. Commercial Beverage Center with 5 Adjustable Wire Shelves, Fan-Forced Cooling, LED Lighting, Digital Thermostat and Factory Installed Lock
18" Undercounter Beverage Cooler with 3.3 cu. ft. Capacity, 4 Adjustable Chrome Shelves, LED Lighting, Digital Display and Digital Thermostat: Glass Door
17" Compact Beverage Cooler with 2.5 cu. ft. Capacity, Double Pane Tempered Glass Door, Automatic Defrost, Factory Installed Lock, Interior LED Lighting and Commercial Use Approved
24" Beverage Center with 150 Can Capacity, 12 Bottle Capacity with 126 Can Capacity, Spillproof Glass Shelves, Beechwood Front Wine Racks, Interior Display Lighting, Tinted Glass Door and Built-in Capability
24" Undercounter Beverage Center with 5.0 cu. ft. Capacity, Adjustable Chrome Shelves, Open Door Alarm, High Temperature Alarm, LED Lighting and Door Lock
30" Built-in Dual-Zone Beverage Center with 66-Bottle Capacity, Adjustable Wooden Shelves, LED Lighting, Digital Thermostats and Factory Installed Locks
19" Undercounter Beverage Center with 4.3 cu. ft. Capacity, 124-Can Capacity, Glass Shelves, Digital Thermostat and Blue LED Display Lighting
5.5 cu. ft. Compact Beverage Center with Glass Shelves, Interior Light, Adjustable Thermostat, Door Lock, ADA Compliant and Commercially Approved
36" Built-in Beverage Center and Wine Storage with 31 Wine Bottle Capacity, 79 12 oz. Bottle Capacity, 123 12 oz. Can Capacity, LED Theater Lighting and Dual Zone Temperature
24" Built-in Beverage Center with 11-Bottle Capacity, 112 Beverage Can Capacity, Electronic Controls and Reversible Door: Black with Stainless Steel Door Trim
19" Beverage Center with 31-Bottle Capacity, 109-Can Capacity, 5 Wooden Racks, Interior Lighting, Temperature Display and Electronic Controls
19" Undercounter Beverage Cooler with 4.0 cu. ft. Capacity, 4 Adjustable Chrome Shelves, Factory Installed Lock, Digital Thermostat, Interior LED Lighting, Automatic Defrost and Commercial Use Approved
24" Undercounter Beverage Center with 5.5 cu. ft. Capacity, Adjustable Glass Shelves, Door Lock, Aluminum Door Trim and Commercially Approved
4.1 cu. ft. Compact All-Refrigerator with 3 Adjustable Wire Shelves, Automatic Defrost, Interior Light, Factory Installed Lock, White Cabinet and Glass Door
17" Compact Beverage Center with 120-Can Capacity, 5 Slide-Out Wire Shelves, Internal Fan-Forced Circulation, Interior LED Light and Mechanical Controls
4.9 cu. ft. Built-in Compact Refrigerator with 4 Adjustable Tempered Glass Shelves, Interior LED Lighting, Digital Touch Pad Control and Full-Extension Crisper Drawer
24" Undercounter Beverage Center with 2 Full-Extension Glass Shelves, Black Soft Coat Wire Wine Rack, Blue LED Showcase Lighting, Door Alert Features, Integrated IQ-Touch Temperature Controls and UV-Filtered Glass Door
15" Beverage Center with 92-Can Capacity, 4 Adjustable/Removable Wire Racks, Double-Paned Glass Door, Digital Temperature Control, Memory IC, Reversible Door and Automatic Defrost
23" Built-in Beverage Center/Wine Cooler with 5.0 cu. ft. & 27 Bottle Capacity, French Doors and Two Temperature Zones
24" Built-In Undercounter Refrigerator with 5.2 cu. ft. Capacity, 2 Wire Racks, Digital Control Panel and Zero Clearance Door Hinge
24" Built-in Undercounter Outdoor Refrigerator with 5.2 cu. ft. Capacity, 2 Adjustable Wire Shelves, Commercial Stainless Steel Construction, 1,000-BTU Compressor and Digital Temperature Control
24" Undercounter Beverage Center with 5.5 cu. ft. Capacity, Glass Shelves, Interior Light, Door Lock, ADA Compliant and Commercially Approved
24" Built-In French-Door Beverage Center with 61 Beverage Can Capacity, 21 Wine Bottle Capacity, 3 Adjustable Tempered Glass Shelves, 5 Full-Extension Wine Racks, Audible Alarm Alerts and Dual Temperature Zones
24" Outdoor Beverage Center with 5.5 cu. ft. Capacity, Interior Light, 3 Wire Shelves, 2 Wooden Wine Racks, Front Lock and Glass Door
24" Built-In Undercounter Outdoor Beverage Center with 16 Wine Bottle Capacity, 41 12-oz. Can Capacity, 5.2 cu. ft. Volume, 2 Wine Racks and 1 General Shelf
24" Undercounter Side by Side Dual Zone Wine/Beverage Cooler with 19 Wine Bottles Capacity, LED Lighting, Security Lock, Auto-Lock Controls and Electronic Controls
24" Built-in Beverage Center with 5.4 cu. ft. Capacity, 85 12-oz. Bottle Capacity, 105 12-oz. Can Capacity, 16 Wine Bottle Capacity, LED Lighting and Star K Certified
5.1 cu. ft. Compact Refrigerator with Adjustable Glass Shelving, Crisper Drawer, 2 Door Bins, Wine Rack, Freezer Compartment, Interior Lighting and Dial Thermostat
17" Beverage Cooler with 1.7 cu. ft. Capacity, Adjustable Shelves, Interior Light, See-thru-Door and Mirrored Framed Finish
24" Built-In Beverage Center with 6 Bottle Capacity, 126 Beverage Can Capacity, 3 Adjustable Tempered Glass Shelves, Digital LED Thermostat and Audible Alarm Alerts
22" Undercounter Beverage Center with 3.0 cu. ft. Capacity, 3 Wire Shelves, Digital Temperature Controls and Display and Automatic Defrost
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text:
Religious Zionist lawmaker refuses to back down, says homosexuality 'an abomination'
Yitzhak Rabin's granddaughter enters politics, runs for Zionist Congress
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Ayatollah publishes book calling to wipe out Israel, give Iran full reign in the Middle East
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My friends went on vacation and all I got was this stupid ISIS flag
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Israel's largest solar field begins flowing to the national grid
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05/11/2014 10:41
Reflection in water.
(photo credit:REUTERS)
Do you practice active listening? I remember standing on a cliff high above the Pacific Ocean in Central California, gazing down at the blue waters, shimmering waves and bright sunlight. I was completely transfixed by the scene. Having lost all critical thought, I was aware of only one sense: sight. Such is the power of sight. It draws us in completely and takes momentary possession of our minds. We stop thinking for ourselves and become what we are looking at. Listening is different. The person talking to you is outside reaching in, grasping for your attention. Sight is active, you reach out to take it in. You open yourself to the scene and let it fill you completely. Listening is passive, you sit back while others seek your attention. It's much harder to be completely open when you're passive and therefore much harder to be fully absorbed by what you hear.However, active listening is the key to genuine communication. Active listening is defined as suspending internal judgement and commentary while focusing entirely on the speaker. You also need to provide cues of being riveted and interested such as maintaining eye contact, nodding your head, making encouraging sounds and where appropriate, asking for clarification. You need to help the speaker feel that you aren't on the outside listening in. You are listening to them, as you would listen to yourself.This puts your interlocutor at ease. They feel understood. They feel that you are on their side. You see things the way they do and share their feelings on the matter. It frees them to speak their mind and communicate their truest feelings with clarity. When they feel judged, they hedge and waste sentences defending their position, which hinders communication. In a debate it makes sense to justify your position, but in conversation the intent is to share thoughts and feelings, not to defend them. A true listener listens from the speaker's point of view. You might have a completely different point of view, but when practicing active listening, your point of view becomes irrelevant. Your goal is to understand the other persons point of view, not to judge it against your own.The more actively you listen, the more you draw out the speaker. The more you draw them out, the more you learn. In fact the more they talk, the more they learn about themselves and about the problem they are discussing. It is often the case that the problem is solved merely by listening. We think we need to offer an opinion to solve a problem, Often, it is through listening that we give the other a chance to fully explore the problem and come to recognize the solution on their own.Rabbi Dov Ber Shneuri, the second Rebbe of Chabad, was once asked why chatting with Hassidim exhausted him. He explained that when a hassid speaks to him, he must shed his own garments and don the hassid's garments so as to listen well. When he considers the problem, he must shed the hassid's garments and don his own so that he understands well. When he shares his advice, he must once again shed his own garments and don the hassid's garments so that he communicates well. It is no wonder that he is exhausted after changing garments three times in a single audience.I know someone who went to the same therapist for fourteen years. He swears by this therapist and claims she solves his problems. For the first ten years she never offered an opinion. She just sat there and listened. As he talked, he felt understood and accepted. He first grew comfortable with himself and slowly began to grow comfortable with his feelings. She made it possible for him to explore his feelings and even acknowledge his faults. His therapist taught him more about himself by listening then she could ever have done by talking.It was only after ten years that he was ready to listen to her and ask for guidance. She began to explain things to him and to encourage him. She understood perfectly that if she had talked earlier, he wouldn't have accepted her advice. After ten years, her words were effective. He was finally ready to listen.It isn't only professionals who need to practice active listening, we all must. When you look directly into my eyes, you ought to see a reflection of yourself. When I listen to you, my mind should be so filled with you that when you look into me, you see yourself. I should think and feel as you do. While listening to you, my thoughts should be irrelevant and my judgement should be suspended. Then, and only then, will I truly understand you.Active listening requires discipline and skill. We must be able to refrain from offering opinions even when asked. The impulse to answer is strong, but your interlocutor benefits more from your silence. The temptation to take ownership of the other persons problem is strong, but we cannot own someone else's problem. We can offer encouragement and support, but not solutions. Instead we nurture them until they find it.In other words, when practicing active listening, you set yourself aside and fill your mind with the other. You think like them, feel like them and listen to them. In a sense you let go of being yourself and become them. As the Rebbe put it, you shed your own garments, your thoughts and perspectives, and don theirs. This requires humility, but it is only with humility that you make a connection.When you are filled with your own thoughts and judgments there is little space for others. To fill yourself with another, you must make space. You must be free of yourself and become transparent.King Solomon wrote, 'As the waters reflect the face [that peers into them] so does the heart reflect the heart.' Waters only reflect the face when they are clear and transparent. When they are murky, they don't reflect at all. The same is true of us. When we become transparent, free of ourselves, our interlocutor feels completely at home in our presence. They look into our face and see a reflection of themselves. They find empathy and understanding, nearly as if they see themselves staring back at them. In other words, active listening means to turn yourself into a mirror.Perhaps this can help us understand why the Torah emphasizes the importance of listening to G-d. The Torah promises reward for listening and punishment for not listening. Even more than obedience, which has its own word in Hebrew, the Torah demands listening. Surely listening includes obedience, but the Torah seems to emphasize listening over obeying.Perhaps the Torah is encouraging active listening. Active listening is setting aside our objections and doubts, filling ourselves with G-d's thoughts. Active listening is humbly setting ourselves aside and becoming fully absorbed by G-d. Active listening is becoming free of ourselves and transparent before G-d. It is a feat worthy of reward. May we perfect the art with our fellow Jews and learn to practice it with G-d.Rabbi Lazer Gurkow, a respected writer, scholar and speaker, is the spiritual leader of Beth Tefilah congregation in London, Ontario. He is the author of Reaching for God: A Jewish Book on Self Help, and his new book, Mission Possible: Living With Higher Purpose will be released this spring and can be pre-ordered by emailing firstname.lastname@example.com
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Share This Product
100.0% would recommend this item to a friend.
0 out of 0 people found the following review helpful:
What are the pros? Great flavor, productive
What are the cons? Can be rubbery
These were my favorite from last year. Awesomely productive, and they had more flavor in my opinion than any of the others we tried. The pods did have a tendency to be a little tough, especially later in the summer, and were especially rubbery after being frozen. Now that I'm thinking about it....that thick hide would made for an awesomely crunchy pickle though. Looks like I'll have to grow them again and report back on that experiment... :)
Seriously though, the beans are great.
Would you recommend this product to a friend?
What are the pros? Fun color
What are the cons? Plants flop over
We planted these beans mid-may and are starting to harvest now that it's July! These seem like really hardy plants, and produce a lot of beans. I haven't tried them cooked yet, because they taste so good right off the vine! I would definitely grow this variety again, and next time give them a little support cage so they don't flop over as the beans mature.
3 out of 3 people found the following review helpful:
What are the pros? Fast, no fuss and productive
What are the cons? None
Relatively compact plants develop quickly. No diseases. They produce a lot of pods, so don't over plant. Check twice a day for new pods. I like mine very tender, so I watch them carefully to not let them over mature. Excellent. Will buy again!
9 out of 9 people found the following review helpful:
What are the pros?
What are the cons? none
Kinda slow to start but once they get going what a wonderful surprise !! I dislike store bought wax bean but thought hmm I'll give these a try and purchased 1 pack of seed. Now i have picked these cooked them and am sad that i didn't buy more lol Butter taste with so much flavor to them. I pick them once a week now and am canning as many as i can. Next year i will buy more. Without a doubt this crop as changed my views on wax beans.
9 out of 10 people found the following review helpful:
What are the pros? Easy to grow, delicious
I grew these in a neglected container garden. They were delicious and kept producing until frost. Had I staked them, I probably would've been overrun with beans. I loved the taste, too.


text:
Explore the personal stories of Syrian refugees in Lebanon
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16 Mar 2014 11:11 GMT | Environment, Humanitarian crises, Asia Pacific, Australia
The eastern Australian states of Queensland and New South Wales are in the grip of the most severe drought ever recorded. Some farmers in Australia are having to shoot their cattle because they cannot afford to feed them.
The financial strain caused by the drought is starting to take a toll on farmers' mental health.
Al Jazeera's Andrew Thomas reports from Broken Hill, west of Sydney.
Source: Al Jazeera
Despite a history of droughts, global climate change will make future droughts worse in US state, says geoscientist.
The price of a hay load has risen from $5,000 to $7,500 in the past month, forcing some farmers to sell their cattle.
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Supreme Council member tells Al Jazeera decision to appoint Mullah Omar's successor was taken without involving seniors.
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text:
Ghana's mixed fortune as a dumping ground for e-waste
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07 Dec 2011 18:06 GMT | Sport, Formula One, US & Canada, Bahrain, United States
Formula One will race in the United States next year after organisers of a new grand prix in Texas reached a deal with commercial supemo Bernie Ecclestone on Wednesday. "Mr Ecclestone received his check today," Red McCombs, a founder of the Circuit of the Americas in Austin, said in astatement. That race, and the Bahrain Grand Prix which had to be cancelled this year due to civil unrest, had looked doubtfulahead of a meeting of Formula One's governing body in New Delhi but both were given the green light. "The 2012 FIA Formula One World Championship calendar was confirmed as previously published," the International Automobile Federation said in a statement. Construction work was halted at the 5.5 kms Circuit of the Americas, which will be the first purpose-built F1 facility inthe United States, last month amid wrangling over fees due to Ecclestone. The 81-year-old Briton had handed organisers a contract ultimatum of this week. Track officials in Austin said the 10-year deal was back on and building work would resume immediately for the November 18 race.Bobby Epstein, another founding partner, said: "Our investors have believed all along that this project has tremendous benefit for our region, and provides a strong economic engine for the future. "We're glad that Tavo's vision of bringing F1 to the people of Texas will become a reality," he said, referring to theoriginal promoter Tavo Hellmund who has now stepped aside. Previous doubtEcclestone had doubted the US race would happen when asked at the season-ending Brazilian Grand Prix last month. "The truth is they're not complying with the terms and conditions of the contract," he said. "And as we make the contract, we will award, the event or not award the event." The race will be the first in the US for Formula One since Indianapolis in 2007.
"We have a substantial number of fans who have expressed interest in buying tickets and hospitality, so today is a win for all of them as much as it is for Circuit of The Americas"
President of Circuit of The Americas Steve Sexton
Another US grand prix is scheduled for New Jersey, on a street circuit against a backdrop of New York's Manhattan skyline, in 2013. "We have a substantial number of fans who have expressed interest in buying tickets and hospitality, so today is a win for all of them as much as it is for Circuit of The Americas," said Steve Sexton, president of Circuit of The Americas, in the statement. There has also been uncertainty about Bahrain's race, cancelled this year due to civil unrest that continues to trouble the Gulf kingdom, although Ecclestone has consistently said the grand prix will go ahead. Bahrain has an April 22 slot on the calendar, later than this year's cancelled race which was kept on the 2011 calendar and then rolled back until events on the ground forced organisers to admit defeat. A bomb placed under a vehicle exploded near the British embassy in Bahrain's capital Manama on Sunday, causing no casualties. A majority of the Formula One teams are British-based.
Source: Reuters
Formula One supremo Bernie Ecclestone has told organisers of U.S. Grand Prix to pay up or the race will be cancelled.
Sport, Formula One, US & Canada, Latin America, Brazil
Formula One boss urges rethink after controversial decision to reinstate Bahrain Grand Prix to F1 calendar.
Sport, Bahrain
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A year after truce collapses El Salvador gangs seek new path to engage government in another truce process.
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text:
The interview today is with author Tara Lighten Msiska on a subject that is, i must confess, very close to my heart. Tara's book is a detailed look at the inner workings of a jobcentre as she spends three weeks undercover, and as the subtitle of her book JobCentre Confidential says; exposing the dark realities behind the scenes of the Department of Work and Pensions. 1,703 more words
Tags » Undercover
Planned Parenthood Accuses Undercover Sting of Horrific Practices
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2 Peter 3
3 First of all, you must understand that in the last days scoffers will come, scoffing and following their own evil desires.
4 They will say,
"Where is this 'coming' he promised? Ever since our fathers died, everything goes on as it has since the beginning of creation."
5 But they deliberately forget that long ago by God's word the heavens existed and the earth was formed out of water and by water.
6 By these waters also the world of that time was deluged and destroyed.
7 By the same word the present heavens and earth are reserved for fire, being kept for the day of judgment and destruction of ungodly men.
8 But do not forget this one thing, dear friends: With the Lord a day is like a thousand years, and a thousand years are like a day.
9 The Lord is not slow in keeping his promise, as some understand slowness. He is patient with you, not wanting anyone to perish, but everyone to come to repentance.
10 But the day of the Lord will come like a thief. The heavens will disappear with a roar; the elements will be destroyed by fire, and the earth and everything in it will be laid bare.
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|By Marketwired .
Article Rating:
|December 7, 2012 08:30 AM EST
CAMBRIDGE, MA -- (Marketwire) -- 12/07/12 -- Sarepta Therapeutics (NASDAQ: SRPT), a developer of innovative RNA-based therapeutics, today announced updated data from Study 202, its open-label, Phase IIb extension study of eteplirsen for the treatment of Duchenne muscular dystrophy (DMD). Patients treated with eteplirsen for 62 weeks and evaluable on ambulatory measures (modified Intent-to-Treat population) maintained a statistically significant clinical benefit on the primary clinical outcome measure, the 6-minute walk test (6MWT), compared to patients who received placebo for 24 weeks followed by 38 weeks of eteplirsen treatment. As reported previously, Study 202 met its primary endpoint of increased novel dystrophin as assessed in muscle biopsies at week 48 and is now in the long-term extension phase in which patients continue to be followed for safety and clinical outcomes.
In the modified Intent-to-Treat (mITT) population, which includes evaluable patients from both the 30mg/kg and 50mg/kg dose cohorts, patients treated with eteplirsen for 62 weeks demonstrated a statistically significant benefit of 62 meters over the placebo/delayed-treatment cohort using a mixed-model repeated measure statistical test. The mITT consisted of 10 of the enrolled 12 patients (4 eteplirsen-treated patients receiving 50 mg/kg weekly, 2 eteplirsen-treated patients receiving 30 mg/kg weekly, and 4 placebo/delayed-treatment patients), and excludes two patients who showed signs of rapid disease progression and lost ambulation by week 24. The eteplirsen treatment cohort (n=6) continued to show disease stabilization and the cohort has shown less than a 5% decline in walking distance on the 6-minute walk test from baseline. The placebo/delayed-treatment cohort (n=4) also demonstrated stability in walking distance from week 36 through week 62 with a less than 10 meter change over this timeframe, the period in which dystrophin was likely produced, with confirmation of significant dystrophin levels at week 48 through analysis of muscle biopsies in these patients.
"We are excited to see continued stability on the 6-minute walk test with more than a year of follow-up where we would otherwise predict a significant decline," said Chris Garabedian, President and CEO of Sarepta Therapeutics. "Furthermore, the placebo / delayed treatment group has shown stability over the last 26 weeks of treatment, the period in which we would expect to see dystrophin levels translate to clinical benefit. These clinical data support our belief that the dystrophin levels we observed at 48 weeks are potentially an important surrogate marker in assessing disease progression in Duchenne and renews our commitment to advance this program forward as we prepare our primary 48 week dataset for discussion with the FDA."
The safety profile of eteplirsen was evaluated across all patients through week 62 and there were no clinically significant treatment-related adverse events, no serious adverse events, and no discontinuations. One patient had a laboratory treatment-related adverse event, a transient elevation of urine protein on a urine dipstick test, however this elevation was not observed on a 24-hour urine protein measurement and resulted in no clinical symptoms or interruption of treatment. This patient did not show elevations of the specific renal markers of cystatin C or KIM-1. Across both the treatment and placebo/delayed treatment cohorts there is evidence of continued stabilization on pulmonary function tests, echocardiogram, muscle strength and clinical laboratory tests over the 62 weeks.
Results from the mITT population, which combines the evaluable eteplirsen-treated patients across the 30mg/kg and 50mg/kg cohorts, have previously been reported and will be used as the primary assessment of ambulatory clinical measures for the remainder of Study 202. Given there was no significant difference between the 30 mg/kg and 50 mg/kg arms on the production of dystrophin through 48 weeks, this mITT population is the most appropriate to assess dystrophin production and its potential predictive benefits on ambulatory clinical outcomes, such as the 6MWT.
Summary of Additional 6MWT Analyses
As pre-specified in both the Study 201 and Study 202 protocols and statistical analysis plans, the 6MWT was evaluated on two consecutive days at time-points that coincided with a muscle biopsy procedure, namely the baseline visit, and weeks 12, 24, and 48. The maximum distance walked of the two measures on any such visits representing the "best effort" score was prospectively defined for inclusion in the statistical analysis. These data were used to represent the primary clinical endpoint in these studies, however only a single measure of the 6MWT will be captured for each timepoint beyond week 48 in which this test is taken.
The 6MWT data were also evaluated through week 62 using the various methods of using the repeated test results including assessments of minimum values, average values, and the day 1 (first measure) values in assessing changes in 6MWT distance from baseline. Given the inherent variability in an effort-dependent outcome, such as a single-measure 6MWT, the robustness of the treatment effect seen with the prospectively specified analysis was confirmed with these additional analyses.
Summary of 6MWT: Eteplirsen versus Placebo/Delayed-Treatment to Week 62*
---------------------------------------------------------------------------- Results by Type of Baseline Adjusted Estimated Treatment p-value Analysis on Repeated 6MWT Value Mean 6MWT Benefit (Eteplirsen 6MWT values (meters) Change minus from Placebo/delayed-Tx) Baseline (meters) ---------------------------------------------------------------------------- ---------------------------------------------------------------------------- Maximum Score 399.7 -15.6 61.9 m less Eteplirsen (n=6) than or ---------------------------------------------- equal to Maximum Score 394.5 -77.6 0.007 Placebo/delayed Tx (n=4) ---------------------------------------------------------------------------- Mean Score 388.6 -4.2 59.5 m less Eteplirsen (n=6) than or ---------------------------------------------- equal to Mean Score 380.3 -63.8 0.012 Placebo/delayed Tx (n=4) ---------------------------------------------------------------------------- Minimum Score 377.5 +7.1 57.1 m less Eteplirsen (n=6) than or ---------------------------------------------- equal to Minimum Score 366.0 -50.0 0.021 Placebo/delayed Tx (n=4) ---------------------------------------------------------------------------- Day 1 Score 379.7 +4.7 59.6 m less Eteplirsen (n=6) than or ---------------------------------------------- equal to Day 1 Score 371.5 -55.0 0.018 Placebo/delayed Tx (n=4) ----------------------------------------------------------------------------
* Note: All analyses are based on Mixed Model Repeated Measures test
Principal investigator, Jerry R. Mendell, M.D. of Nationwide Children's Hospital, will present this data via an oral presentation at the European Neuromuscular Centre (ENMC) Workshop today, December 7, 2012 at 4:20 p.m. UTC/GMT +1 hours/10:20 a.m. EDT. Dr. Mendell's presentation will be posted on the Sarepta website in the "Events & Presentations" section after the session is completed.
About Study 201 and Study 202 (Phase IIb Eteplirsen Study)
Study 4658-US-201 was conducted at Nationwide Children's Hospital in Columbus, Ohio. Twelve boys meeting the inclusion criteria being between 7 and 13 years of age with appropriate deletions of the dystrophin gene that confirm eligibility for treatment with an exon-51 skipping drug, received double-blind IV infusions of placebo (n=4), 30 mg/kg of eteplirsen (n=4), or 50 mg/kg of eteplirsen once weekly for 24 weeks (n=4). Muscle biopsies for evaluation of dystrophin were obtained at baseline for all subjects, and after 12 weeks for patients in the 50 mg/kg cohort and after 24 weeks for patients in the 30 mg/kg cohort. Two placebo patients were randomized to the 30 mg/kg cohort and two placebo patients were randomized to the 50 mg/kg cohort. This study design allowed Sarepta to investigate the relationship of dose and duration of eteplirsen treatment on the production of dystrophin over the course of the 24-week study.
Study 4658-US-202 is the extension study to 201 and continues to assess the long-term safety and efficacy of open-label eteplirsen. The four placebo patients were rolled over to open-label eteplirsen at week 24, with six patients on 30 mgs/kg, and six patients on 50 mgs/kg. Third biopsies occurred at 48 weeks in the original Study 201-treated patients, and at 24 weeks, the same time point, in the original placebo patients. 6MWT was performed at 32 weeks, 36 weeks, 48 weeks and will continue to be performed every 12 weeks going forward.
About Dystrophin
Dystrophin, a large structural protein, is critical to the stability of myofiber membranes in skeletal, diaphragmatic and cardiac muscle, protecting muscle fibers from contraction-induced damage. Loss of functional dystrophin destabilizes the dystroglycan protein complex, impairing its localization to the muscle membrane, and compromising the integrity of the membrane structure. The absence of functional dystrophin results in muscle membrane breakdown with muscle fibers being replaced by adipose and fibrotic tissue.
About the 6-Minute Walk Test
The 6-minute walk test (6MWT) was developed as an integrated assessment of cardiac, respiratory, circulatory, and muscular capacity (American Thoracic Society 2002) for use in clinical trials of various cardiac and pulmonary conditions. In recent years the 6MWT has been adapted to evaluate functional capacity in neuromuscular diseases and has served as the basis for regulatory approval of a number of drugs for rare diseases, with mean changes in the 6MWT ranging from 28 to 44 meters (Rubin 2002, Wraith 2004, Muenzer 2006). Additionally, published data from longitudinal natural history studies assessing dystrophinopathy, a disease continuum comprised of DMD and Becker muscular dystrophy, support the utility of the 6MWT as a clinically meaningful endpoint (McDonald C, et al, Muscle & Nerve, December 2010) in DMD. These data show that boys with DMD experience a significant decline in walking ability compared to healthy boys over one year, suggesting that slowing the loss of walking ability is a major treatment goal.
Modified Intent-to-Treat (mITT)
The 6MWT results were analyzed using the mITT population which excluded two patients who were randomized to the 30 mg/kg weekly eteplirsen cohort who showed signs of rapid disease progression within weeks after enrollment and were unable to perform measures of ambulation beyond 24 weeks. This mITT population consisted of 10 patients (4 eteplirsen-treated patients receiving 50 mg/kg weekly, 2 eteplirsen-treated patients receiving 30 mg/kg weekly, and 4 placebo/delayed-treatment patients).
About the Statistical Methodology
The Mixed Model Repeated Measures (MMRM) test was used for all statistical analyses of the 6MWT results, including for all subgroups. Analysis of Covariance (ANCOVA) for ranked data was used when the assumptions of normality of the dependent variable (the change in 6MWT distance from baseline) were violated. Baseline 6MWT scores and duration since diagnosis were included as covariates.
About Duchenne Muscular Dystrophy and Eteplirsen
Duchenne muscular dystrophy (DMD) is an X-linked rare, degenerative neuromuscular disorder causing severe, progressive muscle loss and a premature death. One of the most common fatal genetic disorders, DMD affects approximately one in every 3,500 boys worldwide. A devastating and incurable muscle-wasting disease, DMD is associated with specific errors in the gene that codes for dystrophin, a protein that plays a key structural role in muscle fiber function. Progressive muscle weakness eventually spreads to the arms, neck and other areas. Eventually, this progresses to complete paralysis and increasing difficulty in breathing due to respiratory muscle dysfunction requiring ventilatory support, as well as cardiac muscle dysfunction leading to heart failure. The condition is terminal, and death usually occurs before the age of 30.
Eteplirsen is Sarepta's lead drug candidate that is designed to address the underlying cause of DMD by enabling the production of a functional dystrophin protein. Data from clinical studies of eteplirsen in DMD patients have demonstrated a broadly favorable safety and tolerability profile and restoration of dystrophin protein expression. Eteplirsen uses Sarepta's novel phosphorodiamidate morpholino oligomer (PMO)-based chemistry and proprietary exon-skipping technology to skip exon 51 of the dystrophin gene enabling the repair of specific genetic mutations that affect approximately 13 percent of the total DMD population. By skipping exon 51, eteplirsen may restore the gene's ability to make a shorter, but still functional, form of dystrophin from messenger RNA, or mRNA. Promoting the synthesis of a truncated dystrophin protein is intended to improve, stabilize or significantly slow the disease process and prolong and improve the quality of life for patients with DMD.
Sarepta is also developing other PMO-based exon-skipping drug candidates intended to treat additional patients with DMD.
About Sarepta Therapeutics
Sarepta Therapeutics is focused on developing first-in-class RNA-based therapeutics to improve and save the lives of people affected by serious and life-threatening rare and infectious diseases. The Company's diverse pipeline includes its lead program eteplirsen, for Duchenne muscular dystrophy, as well as potential treatments for some of the world's most lethal infectious diseases. Sarepta aims to build a leading, independent biotech company dedicated to translating its RNA-based science into transformational therapeutics for patients who face significant unmet medical needs. For more information, please visit us at www.sareptatherapeutics.com.
Forward-Looking Statements and Information
This press release contains forward-looking statements. These forward-looking statements generally can be identified by use of words such as "believes or belief," "anticipates," "plans," "expects," "will," "intends," "potential," "possible," "advance" and similar expressions. These forward-looking statements include statements about the development of eteplirsen and its efficacy, potency and utility in the treatment of DMD and the potential for the creation of novel dystrophin to lead to significant clinical benefit over a longer course of treatment.
Each forward-looking statement contained in this press release is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statement. Applicable risks and uncertainties include, among others: subsequent clinical trials may fail to demonstrate the safety and efficacy of eteplirsen or replicate results; treatment of patients with DMD using eteplirsen over a longer duration may not lead to significant clinical benefit; any of Sarepta's drug candidates, including eteplirsen, may fail in development, may not receive required regulatory approvals, or be delayed to a point where they do not become commercially viable; and those identified under the heading "Risk Factors" in Sarepta's Quarterly Report on Form 10-Q for the three months ended September 30, 2012, and filed with the Securities and Exchange Commission.
Any of the foregoing risks could materially and adversely affect Sarepta's business, results of operations and the trading price of Sarepta's common stock. For a detailed description of risks and uncertainties Sarepta faces, you are encouraged to review the Company's filings with the Securities and Exchange Commission. We caution investors not to place considerable reliance on the forward-looking statements contained in this press release. Sarepta does not undertake any obligation to publicly update its forward-looking statements based on events or circumstances after the date hereof.
Sarepta Investor and Media Contact:
Erin Cox
Email Contact
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|Name: _________________________
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This quiz consists of 5 multiple choice and 5 short answer questions through Section 8.
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(a) Neville.
(b) Louis.
(c) Dr. Crane.
(d) Percival.
3. What is most notable about Jinny's Section 6 monologue?
(a) She does not mention the children she has.
(b) She does not mention any of the other characters.
(c) She speaks solely about herself and Percival.
(d) She speaks in iambic pentameter.
4. What do the characters do upon Percival's arrival in Section 4?
(a) Stand and leave.
(b) Stand to greet him.
(c) Immediately begin recalling the past.
(d) Fall silent.
5. On what street is Rhoda walking when the reader encounters her in Section 5?
(a) Comstock Hill.
(b) Hampton Court.
(c) Strawberry Hill.
(d) Oxford Street.
Short Answer Questions
1. What are the children doing as the novel begins?
2. When Neville hears the significant news in Section 5, to what does he compare it?
3. Which of the speakers expresses an appreciation for natural beauty in Section 3?
4. Who utters Section 4's final words, "Now Percival is gone"?
5. Who arrives to pick up Rhoda at the end of Section 1?
This section contains 230 words
(approx. 1 page at 300 words per page)


text:
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Elizabeth Janet Griswold, 89, of Chattanooga, died on Thursday, January 24, 2013.
"Liz" was born February 12, 1923 in Montello, Wi., to David and Florence Owens. She was married to Arnold Griswold of Madison, Wi., on Jan. 16, 1943. She was stricken with polio in July, 1949, but still was greatly involved in successfully raising two sons while working many jobs from her home. She enjoyed traveling, her crafts, her cross-word puzzles and her family. She moved to Chattanooga from Roswell, Ga., 11 years ago. She was a member of Brainerd Presbyterian Church. She was a devoted wife, mother, grandmother, great-grandmother and servant of The Lord. She was loved by all who knew her.
She was preceded in death by her husband, her parents, two brothers; Owen Owens and Llewellyn Owens both of Wisconsin.
She is survived by her sons, Michael (Alice) Griswold of Moscow, Id., and Jerry (Linda) of Chattanooga, and one brother, Charles Owens of Tucson, Az.; four grandchildren and five great-grandchildren.
A memorial service will be held at 4 p.m. on Saturday, Feb. 2, at Brainerd Presbyterian Church. The family will receive friends at the conclusion of the service.
Visit www.heritagefh.com to share words of comfort to the family and view the memorial tribute.
In lieu of flowers, contributions may be made to Brainerd Presbyterian Church, 1624 Jenkins Road, Chattanooga, Tn. 37421.
Arrangements are by Heritage Funeral Home, 7454 East Brainerd Road, Chattanooga, Tn. 37421.
July 30, 2015
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Senator Bob Corker on Thursday called the Senate highway bill "the very worst of Washington," while Senator Lamar Alexander supported it. Senator Corker, who voted against the bill, said, "The legislation uses 10 years of budget gimmicks and questionable policy changes to pay for only three years of spending. "The Highway Trust Fund ... (click for more)


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Weather News
Rusty creeps towards WABen Domensino, Monday February 25, 2013 - 05:24 EDT
Tropical Cyclone Rusty is slowly moving towards Australia's northwest coast, causing wind, rain and seas to increase.
Rusty became a category 1 tropical cyclone on Sunday afternoon and continues to intensify as it edges towards the Pilbara and Kimberley coasts of Western Australia.
Strong winds lashed the region on Sunday night, gusting to 79 km/h at Rowley Shoals and 76 km/h in Port Hedland before midnight. These winds will increase further today, with a cyclone warning in effect for coastal areas from Broome to Whim Creek, including Port Hedland.
The heaviest rain has so far been falling on the eastern side of the system where winds are blowing onshore. During the 24 hours to 9am on Sunday, 259mm of rain fell at Country Downs. Nearby, Broome Airport had the heaviest rain since March with 51mm.
Rainfall will become very heavy on Monday before the deluge continues into the middle of the week. Totals are likely to be heavier than those that usually accompany these systems due to the slow movement of Rusty, with significant flooding likely in the De Grey catchment and Fortescue.
Rusty is expected to become a severe tropical cyclone on Monday or Tuesday as it approaches the coast.
People in the Kimberley and Pilbara should check latest forecasts and updates at www.weatherzone.com.au
- Weatherzone
© Weatherzone 2013
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Weather News
Strengthening El Nino to reduce rainfall in northern and south-east Australia but wetter conditions for Western Australia
The Bureau of Meteorology has confirmed the El Nino pattern is strengthening in the Pacific and is likely to persist into next year.
Farmers rejoice as deluge fills rain gauges in Perth, Wheatbelt
A low pressure system which has drenched Perth, the South West and parts of the Wheatbelt has farmers rejoicing.
Western Australia caught in heavy rain and thunderstorms
Powerful thunderstorms have been drenching southwestern Australia, with some locations recording their wettest day in over a decade.


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Dent Fix and Ford Showcase AluSpot Aluminum Repair Station at NACE | CARS
Dent Fix Equipment has announced that its AluSpot aluminum repair station will be showcased at the 2014 NACE | CARS show in Detroit. Both Dent Fix and Ford will be displaying the product at booths no. 24018 and 18026, respectively.
Dent Fix says that the five steps for aluminum repair are covered by the tools included in this set: Expose the bare aluminum, apply heat, weld pins, pull the dent and shape the dent. The AluSpot station includes a five-year warranty and is made in the U.S.
The AluSpot station is approved by Ford for aluminum repair.
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VIDEO: SNL's 'Super Bowl Blackout' Cold Opening
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On last night's SATURDAY NIGHT LIVE, the cast took on the recent blackout at the Super Bowl for the show's cold opening. Check it out below!
Pop superstar Justin Bieber served as host and musical guest of this week's Saturday Night Live on NBC.
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Egypt unrest: Leaders plan strike against Muslim Brotherhood as Cairo protest branded threat to national security
Almost 300 people have been killed in weeks of violence since the army deposed the former president
Wednesday 31 July 2013
Egyptian authorities gave the strongest indication yet that security forces were preparing a strike against the Muslim Brotherhood - announcing in a televised statement that the group's month-long Cairo sit-in was a threat to 'national security' and would soon be ended.
The statement, which was issued by the country's interim cabinet, prompted fears that of another deadly confrontation between authorities and Muslim Brotherhood supporters.
The move against the sit-in protest came as it emerged that Egypt's prosecutors have referred three of the Brotherhood's most senior figures for trial.
They include the group's revered Supreme Guide, Mohamed Badie, along with his deputy Khairat al-Shater and senior leader Rashad Bayoumi. All three are wanted for charges related to inciting violence.
At least 300 people have been killed in nationwide clashes since the June 30 - the date the former president Mohamed Morsi was toppled by an army-led coup. The dead include scores of Islamists who have been gunned down during two separate massacres within the space of three weeks - more than 80 of whom were killed on Sunday when police tried to disperse the sit-in at Rabaa.
The developments raised fears that an anti-Islamist crackdown - which has been anticipated by many since an ominous speech by General Abdel Fattah al-Sisi, Egypt's top military commander public face of the coup, last week - is now imminent.
During its televised address, the interim cabinet said that "terrorist acts" and continued traffic disruption were no longer acceptable and "represent a threat to Egyptian national security".
It added: "The cabinet decided to begin taking all necessary measures to address these dangers and put an end to them, commissioning the interior minister to do all that is necessary regarding this matter within the framework of the constitution and the law."
Since the first day of the June 30 revolt, tens of thousands of Mr Morsi's supporters have been maintaining a vigil from two giant tent encampments in separate parts of the city.
The largest, in the suburb of Nasr City in eastern Cairo, has often been filled with tens of thousands of people.
The vast majority of them appear adamant that they will not leave the streets until Mohamed Morsi is reinstated as President - an impossible demand for the Brotherhood's opponents to recognise. Any attempt to clear so many protesters by force would turn into a bloodbath.
This evening [WED] Gehad el-Haddad, a spokesman for the Brotherhood, remained resolute in his assurance that Mr Morsi's supporters would not melt away. "We don't recognise this government and we don't recognise the authorities or the laws they represent," he told Reuters.
Speaking to The Independent, a pro-Morsi activist said he was not afraid of the impending crackdown. "How much worse can it get?" asked Mohamed Soltan, referring to the two massacres which took place this month. "The government doesn't understand that blood is the fuel and fire of revolutions."
Egypt has become dangerously polarised over the course of the past month. Many people - spurred on by a resolutely anti-Brotherhood media - have begun to think of the Islamists camped in Nasr City as little more than a gang of would-be militants.
Statements from the military and television presenters have roused a collective fear of the national "terrorist" threat - conflating a genuine problem of Islamic militancy in North Sinai with scaremongering aimed at followers of Mohamed Morsi.
"The pro-Morsi protest is not a sit-in," said Haitham al-Shawaf, a member of a youth revolutionary group. "The people there are not protesters, they are militants."
In a bid to counter the increasingly trenchant rhetoric emerging from both sides, a group calling itself the Third Square movement has occupied yet another plaza in eastern Cairo with a view to rejecting both the influence of the military and the Muslim Brotherhood.
Yet in a sign of how little traction is being gained by appeals to moderation, the campaign has already earned the opprobrium of Tamarod, the youth movement which spearheaded the June 30 revolt.
The group's spokesman, Mohamed Abdul Aziz, said Third Square was "dividing the people", adding: "They are living in the past. Now is the time for consensus, we need to move forward."
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Ghana's mixed fortune as a dumping ground for e-waste
Who is to blame for the rise of ISIL?
02 Feb 2011 18:58 GMT | Politics, Asia, US & Canada, China, India
Police in India have arrested a former telecoms minister over a massive corruption scandal, officials have said.Andimuthu Raja belongs to a parliamentary ally of the ruling Congress party and his arrest on Wednesday may spark tension between coalition partners and galvanise an opposition that has blocked parliament since November to protest the scandal over mobile phone licences.A spokesman for the Central Bureau of Investigation (CBI), India's equivalent of the Federal Bureau of Investigation (FBI) in the United States, told reporters that Raja was arrested "due to irregularities in the allocation" of mobile licences and spectrum.Raja would be presented before a special court on Thursday, the CBI said.Raja, who was sacked in November, is accused of misuse of his ministerial office to benefit others, criminal misconduct and having unaccounted assets, local television channels reported. He belongs to the regional Dravida Munnettra Kazhagam (DMK) party from the southern state of Tamil Nadu. He has denied any wrongdoing. Investigators also arrested RK Chandolia, Raja's personal aide, and Siddharth Behura, the former telecoms secretary during the time of the spectrum sale, local media reported.
'Monumental loss'The sale of below-market price licences, which a government audit says may have cost India up to $39bn in lost revenues, is the biggest scandal to have hit India in decades.
Manmohan Singh, the Indian prime minister who won re-election in 2009, is accused by the opposition of failing to act against Raja when complaints were raised.The scandal could also overshadow Congress's campaign to win state elections this year."I only wish that the prime minister instead of living in denial had acted three years ago so this huge, monumental loss to the public exchequer had not taken place," Arun Jaitley, leader of main opposition Bharatiya Janata Party (BJP), told reporters.But the Congress party defended Singh, saying he had acted in accordance with the law of the land.
"Nobody will accept that the credibility of the prime minster or the government has been affected," Congress spokesman Abhishek Manu Singhvi told reporters. "That's absolutely wrong ... the integrity of the government is enhanced by allowing law to take its own course independently and objectively."The opposition has shut down parliament since early November, demanding a joint inquiry into the scandal, and further disruption could hit the next session of parliament in late February when the budget is due to be debated.
With no major parties capable of winning a majority on their own in parliament, Indian governments effectively come down to coalition-juggling. The DMK, with 18 seats, is the second biggest ally of Congress in the government.
The DMK has weakened in recent years, relying on support of other parties including Congress to hold power in Tamil Nadu. As a result, it is unlikely the DMK would pull out of the coalition, because it needs Congress as much as Congress needs it.
India is the world's second-fastest growing economy, but ranks 87th on graft watchdog Transparency International's list based on perceived corruption - a worse rating than its neighbour China.
Source: Agencies
Facing opposition fire, Manmohan Singh says those guilty in $40bn telecoms scandal will be "brought to book".
Politics, Asia, India
Parliament adjourns amid angry scenes as MPs demand investigation into delay into probing of licensing scheme "fraud".
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text:
Stunningly detailed pencil drawings from the prolific Marion Balac
French illustrator Marion Balac has got some serious pencil skills on her. The 28-year old Paris resident creates enormous graphite compositions, thick with detail, that are full of dense vegetation and punctuated by large spaces of pure white paper. These homogenous masses seem to creep through the forests like strange ectoplasmic entities. We don't know what they are, but we really like them.
Marion's had a bit of a convoluted journey to full-time illustration, starting out as a cinematographer before travelling across Eastern Europe to run workshops at refugee centres, schools and hospitals. She's recently finished studying at L'Ecole Des Beaux-Arts in Lyon, developing her already refined style and preparing herself for an illustrious career.
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