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If you don't believe in yourself ... no one else will. Believe in you even when you don't believe in yourself might be better for a little boy maybe
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I just want to run a highlighter over the phrase "So love the people who treat you right, forget about the ones who don't". (I love when something so appropriate for the moment comes right to your email inbox. I ♥ bloggers.)
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ST. LOUIS—Kyle Renaud, a Sugar Grove resident and 2008 Kaneland High School graduate, was recently named Great Lakes Valley Conference's Pitcher of the Week. Renaud is in his sophomore year at University of Missouri – St. Louis.
Photos: Giving back before the game
The Kaneland High School baseball team helped unload the monthly food drop


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Cluck-raking journalism
Perhaps you are in a fowl mood this morning. Too much turkey, pie and pinot noir has made your stomach sour and your head hurt. Well then, don't even consider how much worse things would be if you had to get up a to feed your cluckin' chickens.
Then again, maybe you'd like it. Lots of people like chickens, even city dwellers, and the city of
The urban chicken movement has taken flight across the country, as the Longmont Times-Call outlined in this story. In
The rules on whether people can keep them here are somewhat confusing, but that hasn't stopped the Denver Botanic Gardens from offering classes on how to care for an urban flock, as Westword's Joel Warner reported earlier this year in Clucked Up and Clucky Charm (second item).
Stay tuned. It's a issue that just won't fly the coop. -- Jonathan Shikes
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Meir Panim Gives the Gift of Camp to Hundreds of Impoverished Children.
Zaida's presence follows me on my early morning walks to the park. Sometimes I imagine indulging in conversation, asking him what happened to those wondrous days following the Six-Day War, when the entire country belonged to us and our biggest problem was how to fill the vast areas that had fallen into our hands with Jews.
Those were days when we anticipated Jewish immigration from the United States and Europe, and prayed for an end to the Iron Curtain and a large scale aliyah of Russian Jews.
Soon after the war, the building industry boomed. North, East, South, and West Jerusalem were impregnated with building blocks. Up went Ramat Eshkol, Ramot, Gilo, Pisgat Zeev, Har Nof, all new quarters. Young Jews filled empty hilltops in Judea and Samaria, the nation was reacquainted with biblical names like Eilon Moreh, Bet El, Shiloh and Eli, and settlements were established that would soon turn into cities like Ariel and Maaleh Adumim.
"U'vneh Yerushalayim ir hakodesh" – "Rebuild Jerusalem the holy city, speedily in our days." Words from tefillot and zemirot that my Zaida recited and sang, eyes turned heavenward, with genuine tears that rolled onto his beard and into his Kiddush cup. He wanted to live long enough to see those prophetic words implemented.
Some years back, at a U.S. Consulate reception, I met former Knesset member Rabbi Menachem Porush, who told me, "I have fond memories of your Zaida. Over fifty years ago, after the state was declared, I was a young man sent to America to raise funds for the old yishuv that was in dire financial straights. Your esteemed uncle, Sender Gross z"l, was my good friend, and when the ship docked in New York, your uncle invited me to spend my first Friday night in America at your grandparents' home."
Greeted warmly by Zaida, Rabbi Porush sensed the special Shabbos atmosphere emanating from every corner of the Williamsburgh basement apartment. "Your Zaida sang 'Shalom Aleichem' and then he stood to make Kiddush," he said. "You know, I spent five decades as a member of Knesset and have traveled and enjoyed Shabbatot and heard Kiddush in almost every corner of the world, yet a Kiddush such as your Zaida's I cannot ever forget."
Rabbi Porush also remembered Zaida's emotional yearning and love for Eretz Yisrael, expressed in his constantly stated wish to live there. Family and circumstances, however, did not permit the move. Zaida told Rabbi Porush that before World War II, he was one of a small group of local Jews who'd taken out the last pennies of their savings and invested in orchards that they bought in Eretz Yisrael. He dreamed that one day the orchards would bear fruit, and that he would get to taste of them. That investment failed, but he continued to dream.
Zaida woke at dawn every morning hoping that on that particular day he would be able to leave for Eretz Yisrael; it was what kept him going through forty years of American exile.
My grandmother passed away in 1961 on Hoshana Rabbah, and thirty days later Zaida put up a matzeva. His eight married children were mortified that he didn't wait a year, as is customary in America, before unveiling a tombstone. The day after the unveiling, he left his entire family behind, including grandchildren and great-grandchildren, and boarded a flight to Israel. Zaida, who'd waited so many years for the opportunity to live in Eretz Yisrael, wasn't prepared to wait even one extra day.
Ver veist vifil tzeit bleibt – One never knows how much time he's allotted on earth – and my grandfather wanted to be sure to spend his last days and years fulfilling the mitzvah of yishuv Eretz Yisrael.
Having preceded him to Israel by a year, my husband, Sholom, and I were already living in Jerusalem when Zaida arrived in November 1961. He moved into an adjoining building in the same apartment complex, and we looked after him. We had our Shabbat and Yom Tov meals together; of his 26 grandchildren, we were the privileged ones.
The first Chanukah in Jerusalem, I tried to fry latkes the way my Bobba did, but the flame was too high and the burned latkes left a bitter taste in our mouths. I longed for blueberries and pineapple, unavailable in the Holy Land. We were part of an immigrant generation with its own nostalgic cravings. How long would we yearn for old favorites of the American golus?
About the Author: Faigie Heiman is an accomplished short-story and essay writer and the author of a popular memoir titled "Girl For Sale." Born and raised in Williamsburg, Brooklyn, she has lived in Israel for more than fifty years.
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By most accounts, the one person with the political muscle to swing enough Democratic votes to override a veto is Sen. Schumer.
The next day, in a speech in New York to the Council on Foreign Relations, Mr. Kerry substantially upped the ante.
In Israel, the judiciary has established itself as superior to ALL other branches of the government.
The Fifteenth Day of the month of Av became a day of national rejoicing. The moment that had seemed hopeless became the moment of Redemption.
I think the melodies in our religious services have a haunting sound to them that just permeates your guts and gets into your soul. If you have any musical inclination, I think they inspire you to compose.
Cavalier analogies to the Holocaust are unacceptable, but Huckabee's analogy was very appropriate.
Pollard was a Jewish-head-on-a-pike for all American Jews to see and to learn the explicit lesson.
If the Iran deal passes, Obama's WH becomes world's leading financier of terrorism against Americans
{Originally posted to the author's website, FirstOne Through} Some passionate and eloquent liberals have bemoaned the state of inclusiveness among Jews today. Leon Wieseltier, editor of the New Republic penned an angry piece "J Street's Rejection Is a Scandal" about the exclusion in 2014 of J Street from the Conference of Presidents of Major American Jewish Organizations. […]
Magnanimity by Moshe Dayan, allowing Muslim control of the Temple Mount, led to today's situation.
It was modeled upon a similar fund that had been set up by Sephardic Jews in Venice. But Amsterdam's Dotar was initially more ambitious in scope.
Rav Aharon Margalit is a bestselling author – his book, As Long As I Live, has been translated into four languages – and a standing-room only lecturer. Both religious and non-religious audiences flock to hear him. What makes him so extraordinary? Rav Margalit is a Chasidic Jew who experienced incredible challenges from a very young […]
J Street is the vanguard (Jewish face)in support of Obama's Vienna Accords Nuclear Deal with Iran
"I hold the woman's place over that of men in every fundamental aspect of public and private life."
Aunt Hench is a natural charmer. A people person, spunky and quick as only someone small as a light bulb can be, and wherever she is, she is a bright star.
The president's message was one of living peacefully in a Jewish and democratic state, Jews of all stripes unified as brothers, with Arabs or citizens of other religions.
Water: a fluid with life-giving force, a thin liquid even a trickle of which can assure survival. Crops, fields, land, people – we all need water. We need water for growth, for purity, for beauty, for subsistence. What do we do when water sources are depleted? We have learned not to behave like the young […]
Beautiful Site, Joy of all the Earth; two of the seventy names provided for Jerusalem.
Beautiful Site, Joy of all the Earth; two of the seventy names provided for Jerusalem.
At age 104, my mother was still concerned about her relationship with Hashem.
Erev Yom Ha'Atzmaut, 2012: As I return from a visit to my elderly mother in the northern part of Jerusalem, the bus winds its way through ultra-Orthodox neighborhoods. The stone buildings along the route are colorless shades of sand and grey, some new, some old and blackened with age. Men and women rush through busy streets, expressions of pain and joy, helpless and hopeful looks defining their faces.
Turning on the news Thursday night, I expected to hear the wretched daily tally of Kassam/Grad rockets shot from Gaza to into Sderot or Ashkelon; instead, breaking news streamed across the screen about a terror attack taking place that very moment at Yeshivat Mercaz HaRav.
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Great pack n play! It is so easy to assemble and break down quickly. The toy arch is pretty much useless, but it's still cute. Read morePublished 2 months ago by Kelly R.
So easy to put together! Very sturdy, I love the color and Winnie thw Pooh design. Its great! Can't wait to use itPublished 5 months ago by Amazon Customer
it is sturdy , but the so called bassinet as 2 metal bars going across so no matter how much you pad it out . your baby will feel it . Read morePublished 6 months ago by Nikita Thomas-James
Great for having a newborn! I LOVE the bed, the mobile, and the changing table! But the rack slants.Published 10 months ago by Hillarey Filer
It is great, we love it and the baby does too, in fact I was tempted to give it 5 stars... however the color is not quite as shown, so if that is very important to you, think about... Read morePublished 10 months ago by Daniel Wood


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Posts from Baking Ingredients
5 Vegan Substitutes for Eggs in Baking
Tips from The Kitchn
During my years as a vegan, I always kept a box of Ener-G Egg Replacer around for baking. Most of the time people couldn't even tell that my cookies, muffins, and other baked goods were egg-less.
Though I am no longer a strict vegan, I continue to use egg substitutes in some of my baking. However, these days I prefer to go the less-processed route and often use flax seeds instead of eggs or Egg Replacer, but there are many more substitutes you can try instead!
10 Surprising Things You Can Cook in the Microwave
Tips from The Kitchn
We all know what a microwave is for, right? It's for reheating leftovers and steaming broccoli. Yawn. If you're going to give so much precious kitchen real estate to a microwave oven, you better make it work harder than that!
Here are 10 more things you can do with your microwave, from making healthier potato chips to frothing milk foam for your latte.
Recipe: Sticky Caramel-Pecan Babka Loaves
Recipes from The Kitchn
It all started a few months back when Faith connected me with Jerry James Stone and his Three Loaves project. Jerry's simple idea, an easy intro to giving, is that we all make three loaves: one to keep, one for a friend, and one to give to someone in need. A great project with a solid goal, so when Jerry asked if The Kitchn wanted to contribute a recipe, we jumped at the chance.
But what to make? A sandwich loaf felt practical, but ... yawn. I wanted to make something really special. And a little indulgent. Something that would make eyes grow wide and put big smiles on faces, especially those that might not always have reason to smile. So, you tell me — how did I do?
In the Future You Might Have a Liquid Spice Rack
Food News
Next time you go to restock your spice cabinet, you might just be able to replace all those dusty ground spices with liquid spices instead.
Why in the world, you ask? Why would you consider switching to liquid spices? Turns out they have a couple of benefits.
What's the Best Way to Incorporate Coconut Oil When Baking?
Good Questions
Q: I am starting to bake with coconut oil. In my first attempt, the coconut oil remained in a solid form after mixing. What can I do to make it smoother?
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Recipe: Quick & Tender Whole Wheat Muffins
Recipes from The Kitchn
Here's a recipe out of my weeknight playbook: a quick, easy, reliably moist batch of whole wheat muffins. They are a homey accompaniment to soups and salads, and since these only need to bake for 15 minutes, you can start them and be eating in under half an hour. (Leftovers are lovely for breakfast, too!)
Can I Substitute Coconut Flour for Self-Rising Flour?
Good Questions
Q: I am baking a cake that uses almond meal and self-rising flour. Can I substitute coconut flour for the self-rising flour to make the cake gluten-free?
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Aiya Matcha Packs Your Green Tea Recipes Full of Flavor
Product Review
Item: Aiya Cooking Grade Matcha Powder
Price: $19.80 for 100-gram bag
Overall Impression: For the baker or cook who is serious about matcha and likes a strong flavor, this is a great choice. The powder is designed to be more potent than drinking grade matcha, so it shines through when there are other flavors involved.
In the three recipes I tested, it became clear that following a recipe designed for drinking grade matcha would require some tweaking unless you really love that green tea flavor. The most impressive part was the color. I've never seen any matcha this green!
15 Essential Ingredients for Vegetarian & Vegan Pantries
Pantry Tips from The Kitchn
Alongside the usual savory and sweet items that every pantry needs, there are a few ingredients that are particularly useful for vegetarians and vegans, as well as those wanting to eat more meatless meals. All of these items are ideal for adding protein, texture, and flavor to what you're cooking.
Each household's pantry will vary according to personal taste, ethnic background, and food allergies, but these 15 items are a great way to get started.
7 Ways to Use up Hard-Boiled Eggs
Tips from The Kitchn
The surplus of colorful and hard-boiled eggs left after Easter weekend can feel like a blessing or a curse depending on your particular outlook on eggs and how long they've been lingering in your fridge! Here's a list of everything we love to do with leftover hard-boiled eggs. They will fuel healthy breakfasts and lunches all week!


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Film reviews
Fantail (R15)
81 mins
It is no mean feat to produce your first movie in this country - let alone one with a strong local voice and engaging performances which neither takes the mickey out of our special brand of parochialism nor plunges us into Sam Neill's famously identified "cinema of unease".
Kudos therefore goes to writer and lead actress Sophie Henderson and director Curtis Vowell for producing a debut feature that is as charming as its eponymous bird, as resonant as any contemporary Noo Zild story and manages to be both gripping and chortle-out-loud.
Young Tania works nights at the local Horizon petrol station (loosely set in South Auckland) where she listlessly stacks products into enticing fluoro pyramids while dealing with the perils of the late-night, fuel-buying customer.
Tania's aspirations for the future extend to saving up to take her darling younger brother to Australia to see their dad. But her present doesn't look very promising.
It's a slightly audacious move for a young Pakeha woman to speak in a Maori accent in any onscreen context in this country, but it's a mark of Henderson's sure-handed writing and wonderful characterisation that her Tania is entirely credible as a girl caught between two cultures, holding a deep sense of belonging to one.
Tania's lilt endears us to her immediately, and is then played to great comic effect when her store supervisor chides her for talking like that - "Horizon would appreciate it if you'd stop using the voice". The fact he is himself Maori underscores the irony.
Despite its virtually singular setting and a cast of no more than four main characters, Fantail tells a terrifically engaging story which touches on themes of familial longing, identity, loyalty and freedom.
Crucially, every actor puts in an understated yet beguiling performance - well, apart from the hilarious Jarod Rawiri who isn't remotely subtle at all but enlivens an awkward nocturnal courtship with self-deprecating goofiness. As Dean the supervisor, he takes his own advice to the extreme, telling Tania she needs to work on her "positive non-verbal communication" before going all out in his efforts to show off his physical prowess.
The well-crafted story trips along at quite a pace, proffering surprises as well as flashes of nastiness. Thankfully, this delightful girl is with us all the way.
- Sunday Star Times
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OSI-Approved Open Source (152)
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Human Machine Interfaces Software
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Edmond N. ProvostNovember 15,2012Edmont N. Provost
BRANDON Edmond Noel Provost, 88, died Thursday, Nov. 13, 2012, at Porter Medical Center in Middlebury.
A full obituary will be published in a future edition of the Rutland Herald.
Arrangements are under the direction of the Miller & Ketcham Funeral Home in Brandon.MORE IN Obituaries0805 RH Obits Whitman rites no photo no flag Full Story0805 RH Obits Thomas paid photo no flag Full Story0805 RH Obits Rock Brief no photo no flag Full Story
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This Pretzel-Covered S'moresicle Is The Best Thing You'll Eat All Summer
Ice cream. Toasted marshmallows. Chocolate. Graham crackers. Pretzels. Eternal salty-sweet happiness.
2. Salty Pretzel S'Moresicles
Serves 6
1 pint (2 cups) vanilla ice cream, slightly softened in the fridge
3 oz. (1 1/2 cups) mini marshmallows
4 oz. good-quality milk chocolate or chocolate chips
2 tablespoons refined coconut oil
2 graham crackers
10 mini pretzel twists (enough for about 1/4 cup of crumbs)
six 3-oz. paper Dixie cups or popsicles molds
wooden popsicle sticks
Turn on your oven's broiler or preheat the oven to its highest temperature. Spread out the marshmallows evenly on a large baking sheet lined with aluminum foil. Once the oven is hot, slide the marshmallows in and broil or bake on the top rack for about 30-45 seconds, just until they get golden-brown and puffy.
Combine ice cream and toasted marshmallows in a blender or food processor and pulse just until thoroughly mixed, with no big chunks of marshmallow. You can also combine in a bowl and use an immersion blender.
If using popsicle molds, line the molds with plastic wrap before filling them. Divide the mixture evenly between Dixie cups or popsicle molds. Insert popsicle sticks into the center of each cup; if the ice cream has softened too much and sticks won't stay upright, let the pops freeze for 30-60 minutes before inserting them. Freeze for at least 6 hours, until solid.
When you put the pops in the freezer, microwave the chocolate and coconut oil in a heat-proof mug or glass (wide enough to dip pops into), stirring every 30 seconds, until smooth and fully melted. Let cool completely and keep at room temperature while the pops freeze.
Once the pops are frozen solid, crush graham crackers and pretzel twists into coarse crumbs and set out in a shallow dish. If the chocolate sauce has started to solidify, microwave for just a few seconds to re-melt it (but you don't want it to be warm). Stir to make sure it's smooth and fully blended.
Working with one pop at a time, carefully tear off the Dixie cup or plastic wrap. Dip the pop into the chocolate, twirling as you take it out to make sure the sauce is evenly distributed. Immediately, before the chocolate hardens, roll the pop in graham cracker and pretzel crumbs to evenly coat it. Eat right away or freeze on a tray for later.
3. This recipe is one of the delicious contestants in an epic three-day Mix & Mash-Up food tournament happening this week on Good Morning America.
Tune into GMA on ABC between 8 a.m. and 9 a.m., August 18-20, to see more awesome food mash-ups and cast your vote for the winner!
- Dozens of people have died after two passenger trains derailed within minutes of each other on a flooded bridge in central India.
- Fox News has announced the 10 Republican candidates who will participate in the first debate of the 2016 U.S. presidential race on Thursday.
- Record-breaking freediver, Natalia Molchanova, is feared dead. She disappeared while diving off the coast of Spain on Sunday.


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Explore the personal stories of Syrian refugees in Lebanon
Ghana's mixed fortune as a dumping ground for e-waste
26 Apr 2013 18:25 GMT | Business & Economy, US & Canada, United States
US economic growth gained speed to an annual rate of 2.5 percent in the first quarter, but not enough to meet forecasts made by economists.
The Commerce Department said on Friday that gross domestic product (GDP) expanded at a 2.5 percent annual rate, after growth nearly stalled at 0.4 percent in the fourth quarter.
However, the increase missed economists' expectations for a three percent growth pace.
"It wasn't the bang-up start to the year we had hoped for, and the signals from March suggested that we will only decelerate from here into the spring trimester," said Avery Shenfeld, chief economist at CIBC World Markets Economics in Toronto.
Part of the acceleration in activity reflected farmers' filling up silos after a drought last summer decimated crop output. Removing inventories, the growth rate was a tepid 1.5 percent.
Consumer spending, which accounts for more than two-thirds of US economic activity, increased at a 3.2 percent pace - the fastest since the fourth quarter of 2010. It grew at a 1.8 percent rate in the fourth quarter of last year.
However, households cut back on saving to fund their purchases after incomes dropped at a 5.3 percent rate in the first quarter. The drop in income was the largest since the third quarter of 2009.
The saving rate fell to 2.6 percent, the lowest since the fourth quarter of 2007, from 4.7 percent in the fourth quarter of 2012.
Monetary stimulus
The GDP report could give ammunition for the Federal Reserve to maintain its monetary stimulus.
The US central bank, which meets next week, is widely expected to keep purchasing bonds at a pace of $85bn a month.
Although government spending, which fell to a 4.1 percent annual rate, tax increases and federal budget cuts could slow growth later this year.
Data ranging from employment to retail sales and manufacturing weakened substantially in March after robust gains in the first two months of the year. There are indications the weakness persisted into April.
The GDP report showed contributions to growth from all areas of the economy, with the exception of government, trade and investment by businesses in offices and other commercial buildings.
Homebuilding growth
Much of the gains in first-quarter spending came from car purchases and outlays for utilities, which were boosted by unusually cold temperatures.
Consumers managed to step up their spending despite the return of a two percent payroll tax and higher petrol prices.
Despite the spike in petrol prices, inflation pressures were benign in the first three months of the year.
An inflation gauge in the government's GDP report rose at a 0.9 percent rate, the smallest increase since the second quarter of 2012. The personal consumption expenditure index had increased at a 1.6 percent pace in the fourth quarter.
Business spending on equipment and software slowed sharply, growing at an only three percent rate after a brisk 11.8 percent pace in the fourth quarter.
Homebuilding marked an eighth straight quarter of growth, though the pace moderated from the fourth quarter.
Source: Agencies
Evidence suggests investments in infrastructure would boost the economy, but the rich don't need infrastructure.
Business & Economy, US & Canada, Japan, United States
Although it seems counter-intuitive, raising corporate tax rates is not a good way to help US workers.
Business & Economy, US & Canada, United States
The United States is leading secret negotiations with 11 other countries over the Trans-Pacific Partnership Agreement.
Asia Pacific, New Zealand, Health
An alarming number of young UK offenders with criminal records were previously in the care of local authorities.
Europe, Child rights, Law
Caught in cycle of poverty feeding off the informal labour market, Mexico poor grow old on the job, have no retirement.
Human Rights, Latin America, Mexico
Forgiveness, reconciliation and an arms embargo are key ingredients for peace in South Sudan, says Bishop Paride Taban.
War & Conflict, Africa, Sudan
Two homes set ablaze in Duma village in occupied West Bank, with graffiti left on the walls reading "revenge" in Hebrew.
War & Conflict, Middle East, Occupied West Bank, Israel
Independent judicial panel rules three plant operator executives should be tried for negligence over disaster in 2011.
Politics, Health, Asia Pacific, Japan
The devastating impact that war and living under the constant threat of drones has had on the people of Afghanistan.
War & Conflict, Health, Afghanistan
Eyal Weizman explains architecture's key role in the Israeli occupation of Palestine and the evolution of urban warfare.
Human Rights, Israel, Palestine
An investigation into the role of one of the most influential banks in the world.
Business & Economy, Greece, US & Canada
There is a unique and dangerous commerce system at work in Amazonia, where children risk their lives for a few pennies.
Business & Economy, Latin America, Brazil


text:
Posts tagged "Los Angeles Angels"
Sox Sign RHP John Bachanov
As was noted Wednesday by Kevin Goldstein on Twitter, the Sox have signed former 1st round supplemental pick of the Angels, RHP, John Bachanov. Baseball America had this to add in their transaction report: The Angels' top pick in the '07 draft, reliever Jon Bachanov follows the Bobby Jenks career path from Anaheim to Chicago.... Read more »
Recent posts
Top White Sox Prospects, Midseason 2015: Players ranked 16-30 »Matt Cassidy on Future SoxPosted today at 10:54 am
White Sox Minor League Recap 8/2/2015: Lowry and Cooper pitch Intimidators to win »Rob Young on Future SoxPosted today at 10:04 am
White Sox Minor League Recap 8/1/2015: Adams in control as Intimidators roll »Rob Young on Future SoxPosted August 2, 2015 at 12:57 pm
White Sox Prospects of the Month - July 2015 »Dan Santaromita on Future SoxPosted August 1, 2015 at 8:55 pm
White Sox Minor League Recap 7/31/2015: Barnum and Michalczewski power the Dash »Daniel Shapiro on Future SoxPosted August 1, 2015 at 2:26 am
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Unspoilt clean sandy beach, well worth a visit! If you're lucky in the summer months you can see dolphins in the moray firth, lovely walks along the promenade and nice parks and...
read more
Unspoilt clean sandy beach, well worth a visit! If you're lucky in the summer months you can see dolphins in the moray firth, lovely walks along the promenade and nice parks and tearoom along the way.
love Nairn beach, visited numerous times over the years as both a child, and adult and with my own children. Really accessible, clean sand and water and lovely views
Lovely long safe beach, well two beaches in fact as there are east and west beaches in Nairn, both miles of golden sand, close to amenities.
The beach has beautiful, pristine sand and lovely rocks and grasses. Of course the water was much too cold for a dip--even in June. But I enjoyed the walk and the scenery. I was told this beach was a favorite of Charlie Chaplin.
Scotland is blessed with some of the finest beaches in Europe and Nairn beach must be amongst the best. Parking is easy to get to and right next to the beach. Even at peak period, you wouldn't call the beach busy and we have often had it to ourselves. Outstanding
Fairly quiet town centre. Traditional resort - hey day perhaps in the past. There are glorious views of the Highlands to the North and West. Beach wanderers and twitchers will love this place.
We walked east from Nairn for nearly 2 hours, staying on the sand, before turning back. There is also a proper path at the edge of the woods lining the route.
One of the best beaches I have visited. Well kept and seems to go on forever. Definitely worth a walk along the beach, even on a cold day.
fantastic well kept beach, Unspoiled with nice walkway to the harbour. Of course the sun was shining so that was an added bonus
always plenty room to enjoy your day even at its busiest. my wife and i moved from inverness to nairn 2 years ago. and go for walks on the beach daily.paradise!!
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what is the tide like ?
See all questions


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Comments about 'Work begins on Calif. bullet train as costs swell to $68 billion and locals fight against it'
- Oldest first
- Newest first
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We are, I believe, entering an era where absolutely nothing can be built anywhere, ever, without someone, or some group, objecting to it in an empowered way. No dam, cel phone tower, road, pipeline or power line is sufficiently important to the common good that someone won't object to it; their reasons are myriad. Objections range from aesthetic to archaeological to the old standbys like traffic and noise, or even the welfare of bats or migrating salamanders. The concept of 'drill baby' quickly becomes NIMBY and then BANANA (build absolutely nothing anywhere near anybody) if it's going to be visible from someone's house. I'm not surprised people oppose this rail link. I imagine there were people who opposed the original transcontinental rail links. But that doesn't mean it was a bad idea.
- 1:10 p.m. Oct. 20, 2013
- Like
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Jerry "Moonbeam" Brown and the bullet train.
Dumb and dumber.
- 2:06 p.m. Oct. 20, 2013
- Like (2)
- Report abuse
A lot of money earmarked to Florida was reprogamed to California. Our Gov.
refused the money since it came from the President, the only reason.
You can send it back after next election please.
- 2:38 p.m. Oct. 20, 2013
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@morpunkt - I agree.... we just need more 4 lane freeways..... that will solve the problem... Why would anyone want options when it comes to travel. Be a proper American, buy a car and sit in the middle of traffic like the rest of us... or go back to your fancy pants asian and european counties where this stuff works. We don't solutions.... we just want to complain and tell everyone else how stupid they are.
- 3:42 p.m. Oct. 20, 2013
- Like (1)
- Report abuse
OUR federal tax dollars at work, building an over priced toy that no one will
use, and will require subsidies for the next 100 years to keep it operating.
A total waste of money we have to borrow from China. We will pay more in interest alone on this project that it will ever make in profits, and it will never pay for itself.
But, we cannot cut a single dollar of federal spending, we are told. This would have been a good place to start. It is a good place to start now, and a good place to start tomorrow, even if half built.
- 4:05 p.m. Oct. 20, 2013
- Like (2)
- Report abuse
Having lived in California for decades, I've seen a lot of stupid
decisions, but none with the horribly large financial impact of this one!
This will never pay for itself and never run at capacity but will create thousands of construction and maintenance jobs at a cost that is around 50 times the salary of each job created.
CA will still be paying for this boondoggle for many decades after it is decommissioned!
- 5:06 p.m. Oct. 20, 2013
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"one of the possible routes" --- $13.2 Billion was approved for a
project they are now *guessing* will cost $68 billion. And (oopsie) the bullet
train ride is looking more like car travel time.
Is this an exercise in faith, or folly?
- 5:12 p.m. Oct. 20, 2013
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Clown Brown and the Sacramento Circus continue to keep the unions and their
votes in their pockets. This "speed" train is not about what is good
for California. It's this kind of stuff that continues to drive
"producers from California into other, more tax friendly places to
Bob Tait, Phelan, California.
- 5:43 p.m. Oct. 20, 2013
- Like (2)
- Report abuse
DeseretNews.com encourages a civil dialogue among its readers. We welcome your thoughtful comments.
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Busy place, friendly staff, good food and good portion sizes. Large menu plus specials and a good range of prices
Perfect end to the day with a meal in this pub. Full of locals which is always a good sign. Ate from the specials menu and could not fault it at all. Well worth a visit and good food and service.
We went for Sunday Lunch while on holiday. Four of us all had roast dinners and it was lovely. Staff were very helpful and would definately go again.
We stayed in a local camp site and visited this amazing pub. Friendly staff, great atmosphere and brilliant location. The other customers were all nice. Great garden. I tried the mussels and they blew my mind, so incredibly tasty, absolute must if you pay this awesome place a visit. I cant wait to go back just for the mussels!
I have been going to the Smugglers in for many years, i have never once had a bad meal there. Lately I decided on a radical diet change and became a vegetarian, still relatively new to veggie cuisine i took the plunge and ordered the Spicy Bean Burger, and my risk paid off! Made by hand, perfectly seasoned and the...
Three of us went for lunch as recommended by the ferry boat driver but it was a big mistake
The food is very poor & the pub looked nice from the outside but not great inside.
The service is ok
Managed to get a table it is obviously a busy place as they were nearly all reserved. Had cheesy garlic mushrooms to start which were very good but a chunk of crusty bread would have gone down so much better than a slice of white! Smugglers chicken for main was OK, partners liver and bacon was much better, his Caesar...
Went out for an evening meal at the smugglers inn. Although I ordered vegetarian lasagne I was presented with a meat one. The owner was quick to exchange and apologized profusely and offered us a free coffee. My husband had the rump steak and the meal was enjoyable. Staff were very friendly. A very busy place so if you are...
Visited this pub whilst on a visit to the area. Wanted to order the nachos and asked if it would be possible to add chilli - the lady serving behind the bar who was serving the entire bar asked the kitchen and they said that everything came "portioned" and an extra portion would be £3!!! All I wanted was a...
I have just returned to my holiday apartment after taking my wife for a meal at The Smugglers' having been recommended by other visitors and, I might say many people on Tripadvisor. My first impressions of the place were that the staff were off-hand and that it was not particularly welcoming. We ordered food and drinks and were sent to...
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Monday, 05 Mar 2012 10:01 PM
DAKOTA CITY, Nebraska (AP) — Call it McWashington.
A Nebraska woman has sold a three-year-old McDonald's Chicken McNugget that resembles President George Washington for $8,100 on eBay.
The Sioux City Journal in Iowa says bidding ended Monday morning.
Rebekah Speight of Dakota City sold the McNugget to raise money for a drive to raise $15,000 and send 50 children to summer church camp in Sioux City. She did not disclose who won the auction.
Speight says her children didn't eat the chicken during a McDonald's visit three years ago. She was about to toss it, then spotted Washington's resemblance. Speight stashed the McNugget in her freezer.
eBay had temporarily taken down the auction last month because it violated rules regulating expired food.
She later received an email saying the site was "willing to make exceptions to help your cause."
© Copyright 2015 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Thursday, 30 Jul 2015 21:44 PM
An evangelical Christian college in suburban Chicago is refusing to buckle under Obamacare's controversial contraception . . .
Thursday, 30 Jul 2015 21:34 PM
New Jersey Gov. Chris Christie, a Republican presidential candidate, is also a former U.S. attorney, and he says he sees . . .
Thursday, 30 Jul 2015 19:35 PM
Indiana on Thursday cleared Planned Parenthood facilities that perform abortions in the state of any wrongdoing in the h . . .
Would prefer a Trump-Fiorina ticket... Palin could serve in his admin in some...
When the republicans offer up a milquetoast candidate as they have for the past...
If the Dems continue to support PP then I can no longer support them. This...
Well, so much for The Donald's campaign being over due to the negative comments...
What a waste of good news space. Okay folks, here's the options for how this...
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text:
Score +47
Deal DetailsPromoted 01-16-2014 at 10:44 PM View Original Post
Note, certain restrictions apply, please refer to the rebate for complete details. Please refer to our forum thread for the best deals.
Original Post
For a limited time only you can get $10 back on orders over $50 after exclusive mail-in rebate.
See Terms. Restrictions Apply. NOTICE: Limit (1) ONE rebate per person, billing address, company, or household
$10 back on any $50 order (net of any coupons or other discounts) excluding gift cards on a single transaction receipt, for orders made at TigerDirect.com, TigerDirect.ca, and TigerDirect.pr. Valid from 12:00AM ET on Friday, January 17, 2014 through 11:59PM ET on Friday, January 24, 2014. Rebate redemption does not invalidate eligibility of other product specific rebates or promotions. Eligibility is limited to end-consumers only. Business customers or commercial resellers are ineligible to participate in this offer. Rebate must be postmarked within 60 days of purchase. Order must ship for rebate to be valid. Cancelled or returned orders are ineligible for rebate redemption, and any refund or credit resulting from an item returned after rebate issuance will be reduced by the amount of the rebate. Limit only ONE (1) rebate per person, billing address, or household. The rebate is in USD currency and may be paid with a prepaid reward card. It is recommended to keep copies of all materials submitted for your records. Click here for more details and to download the rebate.
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Possible 10% cash back on any TigerDirect purchase with a Bank of America card. Check the Cash Back Deals [bankofamerica.com] tab on your account. Not sure if this is targeted or not.
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They lost 3 of mine from around the same time. Contacted CS and they told me to send them copies through e-mail. Did that 4 days ago and they haven't said anything back.


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TRENDnet TEG-240WS 24-Port Gigabit Web Smart Switch - Final ThoughtsNeed to setup a LAN Party or looking to enhance your home network? TRENDnet's TEG-240WS 24-Port Gigabit Web Smart Switch could be your answer.
Final Thoughts
The TEG-240WS is intended as an enterprise class product, but it has some significant performance improvements that make it work in a LAN Party setup or in a mixed home network for the enthusiast or Pro-Sumer. Advanced features like Jumbo Frame, Trunking, IGMP and VLANs make it a very versatile product.
The VLAN feature makes it practical to use as a single solution for a home office, home network, console network setup while the TEG-240WS' processor has the power to keep all of those networks running at top speed.
As the lines blur between what was formerly an enterprise only configuration and what we see in the future for home networks, products like the TEG-240WS will find their way into more and more homes. The price tag of249.99 USD will be a small price to pay for the features and functions, while products like Windows Home Server, Sage Media Server and other home media servers will only serve to quicken the trip of the TEG-240WS and its smaller bother, the 16-port TEG-160WS into the home.
PRICING: You can find products similar to this one for sale below.
United States: Find other tech and computer products like this over at Amazon's website.
United Kingdom: Find other tech and computer products like this over at Amazon UK's website.
Australia: Find other tech and computer products like this over at PLE Computer's website.
Canada: Find other tech and computer products like this over at Amazon Canada's website.
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How Can Your Life Become God-Centered?
Image bearers of God
Image bearers of God
Whatever piece of the wisdom of Proverbs 31 that particularly resonates with you, either positively or negatively, engage the Spirit with Bible study and prayer over it. Make certain that it is He that is convicting you and not another woman that He has led to apply it in a way that is only wise in her home, not yours. While guilt is a lousy motivator, the Spirit whispering through the Word is not. He will lead you well to apply this wisdom in ways that are wise for the home and relationships to which He has called you,
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The Surprising Beliefs of the Great Theologians of...While all of these theologians of the past held to Christian orthodoxy, they...
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Is Social Media Sabotaging Real CommunicationSocial media tools like Twitter, Instagram, and Snapchat are becoming the new...
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A CNBC reporter since 1990, Bob Pisani has reported on Wall Street and the stock market from the floor of the New York Stock Exchange for more than a decade. Pisani covered the real estate market for CNBC from 1990-1995, then moved on to cover corporate management issues before moving to the New York Stock Exchange in 1997.
He was nominated twice for a "CableACE Award"—in 1993 and 1995.
In 2013, he won Third Place in the National Headliner Awards in the Business and Consumer Reporting category for his documentary on the diamond business, "The Diamond Rush."
In 2014, Bob was honored with a Recognition Award from the Market Technicians Association for "steadfast efforts to integrate technical analysis into financial decision making, journalism and reporting."
Prior to joining CNBC, Pisani co-authored "Investing in Land: How to Be a Successful Developer." He and his father taught a course in real estate development at the Wharton School of Business at the University of Pennsylvania from 1987-1992. Pisani learned the real estate business from his father, Ralph Pisani, a retired real estate developer.
Follow Bob Pisani on Twitter @BobPisani.
After the close, Apple reported earnings and sales well above expectations: $3.33 per share (consensus was $2.45) on topline of $13.5 billion (consensus $12 billion). Guidance of $2.28 to $2.39 is well below expectations of $2.45 — that conservative guidance is typical of Apple.
After closing not far from the lows on Friday, the S&P 500 closed at its high yesterday and is sitting just off the highs for the day as of this writing. Volume is again trending toward the heavy side.
Volume picks up, but careful how you interpret the numbers. Traders have been MISERABLE, even as major indices have moved to new highs, because volatility and volume have been so low. They've been a little happier recently...
We opened positive on generally good corporate earnings, positive economic data in Europe and opening above the psychologically important 1200 level for the S&P 500. Even thought the Dow is relatively flat, there are THREE stocks advancing for every ONE declining...
European stocks are up. And US earnings season is in full swing.
A phony rally? This is why pros do not like the Dow: As of this writing, the Dow has moved 60 points in the past 45 minutes, it is now up 40 points for the day, but wait a minute: there are 2 stocks declining for every 1 advancing at the NYSE!
Word that the SEC vote to sue Goldman Sachs was 3-2, right along party lines (first reported by Bloomberg), came out a bit after 2pm ET and helped lift Goldman and the overall market.
Banks mostly flat, with modest weakness in the larger regional banks. It's a good sign: the Bank Index (BKX) rallied almost 25 percent from the February low to the high last Thursday, and declined only 3 percent on Friday. There are three clear risks...
Negotiations over Greece's debt crisis have been delayed...because the airspaces have been closed due to the Iceland volcanic eruption. AND: Don't let the Goldman story, as important as it is for some financial firms, distract you from the main story: earnings are getting better.
The political fur is flying on Wall Street over the Goldman Sachs allegations.Few are trying to defend Goldman if the substance of the allegations are correct; however, the Obama administration has many enemies on the Street. Many are openly questioning the timing of the announcement. Why? Because a vote on financial reform is imminent...and victory is not assured.
"Money for nothing" interest rate policies have failed, the bond guru said in a broadside against global central banks.
Bank of Ireland, which was bailed out during the country's debt crisis, reported soaring profits for the first half of 2015 as bad debts were reduced.
Lloyds Banking Group reported a 15 percent jump in pre-tax profit for the first half of 2015 to £4.4 billion ($6.9 billion) on Friday.


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Publications (301)627.96 Total impact
Article: Lysophosphatidic acid increases the proliferation and migration of adipose‑derived stem cells via the generation of reactive oxygen species.[Show abstract] [Hide abstract]
ABSTRACT: Phospholipid derivatives, such as lysophosphatidic acid (LPA), exhibit mitogenic effects on mesenchymal stem cells; however, the molecular mechanism underlying this stimulation has yet to be identified. The aims of the present study were as follows: To evaluate the stimulatory effects of LPA on the proliferation and migration of adipose‑derived stem cells (ASCs); to study the association between reactive oxygen species (ROS) and LPA signaling in ASCs; and to investigate the microRNAs upregulated by LPA treatment in ASCs. The results of the present study demonstrated that LPA increased the proliferation and migration of ASCs, and acted as a mitogenic signal via extracellular signal‑regulated kinases 1/2 and the phosphoinositide 3‑kinase/Akt signaling pathways. The LPA1 receptor is highly expressed in ASCs, and pharmacological inhibition of it by Ki16425 significantly attenuated the proliferation and migration of ASCs. In addition, LPA treatment generated ROS via NADPH oxidase 4, and ROS were able to function as signaling molecules to increase the proliferation and migration of ASCs. The induction of ROS by LPA treatment also upregulated the expression of miR‑210. A polymerase chain reaction array assay demonstrated that the expression levels of adrenomedullin and Serpine1 were increased following treatment with LPA. Furthermore, transfection with Serpine1‑specific small interfering RNA attenuated the migration of ASCs. In conclusion, the present study is the first, to the best of our knowledge, to report that ROS generation and miR‑210 expression are associated with the LPA‑induced stimulation of ASCs, and that Serpine1 mediates the LPA‑induced migration of ASCs. These results further suggest that LPA may be used for ASC stimulation during stem cell expansion.Molecular Medicine Reports 07/2015; DOI:10.3892/mmr.2015.4023 · 1.48 Impact Factor
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ABSTRACT: Aripiprazole (ARI) is a commonly prescribed medication used to treat schizophrenia and bipolar disorder. To date, there have been no studies regarding the molecular pathological and immunotoxicological profiling of aripiprazole. Thus, in the present study, we prepared two different formulas of aripiprazole [Free base crystal of aripiprazole (ARPGCB) and cocrystal of aripiprazole (GCB3004)], and explored their effects on the patterns of survival and apoptosis-regulatory proteins under acute toxicity and cytotoxicity test conditions. Furthermore, we also evaluated the modulatory activity of the different formulations on the immunological responses in macrophages primed by various stimulators such as lipopolysaccharide (LPS), pam3CSK, and poly(I:C) via toll-like receptor 4 (TLR4), TLR2, and TLR3 pathways, respectively. In liver, both ARPGCB and GCB3004 produced similar toxicity profiles. In particular, these two formulas exhibited similar phospho-protein profiling of p65/nuclear factor (NF)-κB, c-Jun/activator protein (AP)-1, ERK, JNK, p38, caspase 3, and bcl-2 in brain. In contrast, the patterns of these phospho-proteins were variable in other tissues. Moreover, these two formulas did not exhibit any cytotoxicity in C6 glioma cells. Finally, the two formulations at available in vivo concentrations did not block nitric oxide (NO) production from activated macrophage-like RAW264.7 cells stimulated with LPS, pam3CSK, or poly(I:C), nor did they alter the morphological changes of the activated macrophages. Taken together, our present work, as a comparative study of two different formulas of aripiprazole, suggests that these two formulas can be used to achieve similar functional activation of brain proteins related to cell survival and apoptosis and immunotoxicological activities of macrophages.Korean Journal of Physiology and Pharmacology 07/2015; 19(4):365-72. DOI:10.4196/kjpp.2015.19.4.365 · 1.26 Impact Factor
Article: Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana.[Show abstract] [Hide abstract]
ABSTRACT: Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the structural value of Cb-BF-derived anti-cancer drugs, we employed various chemical moieties to produce a novel Cb-BF-derived chemical derivative, KTH-13-amine-monophenyl [4-isopropyl-2-(1-phenylethyl) aniline (KTH-13-AMP)], which we tested for anti-cancer activity. KTH-13-AMP suppressed the proliferation of MDA-MB-231, HeLa, and C6 glioma cells. KTH-13-AMP also dose-dependently induced morphological changes in C6 glioma cells and time-dependently increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, the levels of the active full-length forms of caspase-3 and caspase-9 were increased. In contrast, the levels of total forms of caspases-3, caspase-8, caspase-9, and Bcl-2 were decreased in KTH-13-AMP treated-cells. We also confirmed that the phosphorylation of STAT3, Src, and PI3K/p85, which is linked to cell survival, was diminished by treatment with KTH-13-AMP. Therefore, these results strongly suggest that this compound can be used to guide the development of an anti-cancer drug or serve as a lead compound in forming another strong anti-proliferative agent.Biomolecules and Therapeutics 07/2015; 23(4):367-73. DOI:10.4062/biomolther.2015.021 · 0.84 Impact Factor
Article: Description of the new phototrophic dinoflagellate Alexandrium pohangense sp. nov. from Korean coastal waters[Show abstract] [Hide abstract]
ABSTRACT: The planktonic phototrophic dinoflagellate Alexandrium pohangense sp. nov. isolated from the coastal waters off Korea is described from living and fixed cells by light and scanning electron microscopy (SEM). DNA sequence data were collected from the small subunit (SSU), the large subunit (LSU), internal transcribed spacer regions (ITS1 and ITS2), and 5.8S of the ribosomal DNA (rDNA). The SSU and LSU rDNA sequences of the new dinoflagellate were 4-7% and 14-17%, respectively, different from those of Alexandrium minutum, Alexandrium ostenfeldii, Alexandrium tamutum, Alexandrium margalefii, and Alexandrium pseudogonyaulax, the most closely related species. In addition, the 5.8S rDNA sequence of the new dinoflagellate was also 12% different from those of A. minutum, A. ostenfeldii, A. tamutum, and Alexandrium peruvianum. In a phylogenetic tree based on LSU rDNA sequences, A. pohangense formed a clade with A. margalefii, and this clade was clearly distinct from the clade of A. minutum, Alexandrium diversaporum, A. tamutum, Alexandrium leei, A. ostenfeldii, and Alexandirum andersoni. Moreover, in a phylogenetic tree based on SSU rDNA sequences, A. pohangense was positioned at the base of the clade containing A. leei and A. diversaporum. Morphological analysis showed that A. pohangense has a Kofoidian plate formula of Po, 4′, 6′′, 6c, 8s, 5′′′, and 2′′′′, which confirmed its assignment to the genus Alexandrium. This dinoflagellate has a wide rectangular 1′ plate, the upper left side of which is slightly bent, protruding, and touching the 2′ plate, unlike A. margalefii, which has a wide rectangular 1′ plate that does not touch the 2′ plate, or A. pseudogonyaulax and Alexandrium camurascutulum, which have a narrower elongated pentagonal 1′ plate that touches the 2′ plate. Furthermore, the 1′ plate of A. pohangense meets the 1′′ plate as a straight vertical line, whereas that of A. camurascutulum meets the 1′′ plate as an inclined line because it is lifted by the intrusion of the 1′′ plate. In addition, A. pohangense had a relatively small ventral pore whose majority was located on the 4′ plate, unlike A. margalefii or A. pseudogonyaulax, which have a relatively large ventral pore whose majority is located on the 1′ plate. Furthermore, A. pohangense had pores of two different sizes on the cell surface, unlike A. margalefii and A. pseudogonyaulax, which have similar pores of only one size. On the basis of morphological and phylogenetic criteria, it is proposed that this is a new species of the genus Alexandrium.Harmful Algae 06/2015; 46:49-61. DOI:10.1016/j.hal.2015.05.004 · 3.34 Impact Factor
Article: Enhanced biocompatibility and wound healing properties of biodegradable polymer-modified allyl 2-cyanoacrylate tissue adhesive[Show abstract] [Hide abstract]
ABSTRACT: As poly L-lactic acid (PLLA) is a polymer with good biocompatibility and biodegradability, we created a new tissue adhesive (TA), pre-polymerized allyl 2-cyanoacrylate (PACA) mixed with PLLA in an effort to improve biocompatibility and mechanical properties in healing dermal wound tissue. We determined optimal mixing ratios of PACA and PLLA based on their bond strengths and chemical structures analyzed by the thermal gravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. In vitro biocompatibility of the PACA/PLLA was evaluated using direct- and indirect-contact methods according to the ISO-10993 cytotoxicity test for medical devices. The PACA/PLLA have similar or even better biocompatibility than those of commercially available cyanoacrylate (CA)-based TAs such as Dermabond® and Histoacryl®. The PACA/PLLA were not different from those exposed to Dermabond® and Histoacryl® in Raman spectra when biochemical changes of protein and DNA/RNA underlying during cell death were compared utilizing Raman spectroscopy. Histological analysis revealed that incised dermal tissues of rats treated with PACA/PLLA showed less inflammatory signs and enhanced collagen formation compared to those treated with Dermabond® or Histoacryl®. Of note, tissues treated with PACA/PLLA were stronger in the tensile strength compared to those treated with the commercially available TAs. Therefore, taking all the results into consideration, the PACA/PLLA we created might be a clinically useful TA for treating dermal wounds. Copyright © 2015 Elsevier B.V. All rights reserved.06/2015; 51. DOI:10.1016/j.msec.2015.02.042
Article: Enhanced biocompatibility and adhesive properties of modified allyl 2-cyanoacrylate-based elastic bio-glues[Show abstract] [Hide abstract]
ABSTRACT: Despite cyanoacrylate's numerous advantages such as good cosmetic results and fast application for first aid, drawbacks such as brittleness and local tissue toxicity have limited their applicability. In this study, to improve both the biocompatibility and mechanical properties of cyanoacrylate, allyl 2-cyanoacrylate (AC) was pre-polymerized and mixed with poly(l-lactide-co-ɛ-caprolactone) (PLCL, 50:50) as biodegradable elastomer. For various properties of pre-polymerized AC (PAC)/PLCL mixtures, bond strength, elasticity of flexure test as bending recovery, cell viability, and in vivo test using rat were conducted and enhanced mechanical properties and biocompatibility were confirmed. Especially, optimal condition for pre-polymerization of AC was determined to 150°C for 40min through cytotoxicity test. Bond strength of PAC/PLCL mixture was decreased (over 10 times) with increasing of PLCL. On the other hand, biocompatibility and flexibility were improved than commercial bio-glue. Optimal PAC/PLCL composition (4g/20mg) was determined through these tests. Furthermore, harmful side effects and infection were not observed by in vivo wound healing test. These results indicate that PAC/PLCL materials can be used widely as advanced bio-glues in various fields. Copyright © 2015. Published by Elsevier B.V.Colloids and surfaces B: Biointerfaces 05/2015; 133. DOI:10.1016/j.colsurfb.2015.05.004 · 4.29 Impact Factor
Article: Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain[Show abstract] [Hide abstract]
ABSTRACT: Kaempferol (KF) is the most abundant polyphenol in tea, fruits, vegetables, and beans. However, little is known about its in vivo anti-inflammatory efficacy and mechanisms of action. To study these, several acute mouse inflammatory and nociceptive models, including gastritis, pancreatitis, and abdominal pain, were employed. KF was shown to attenuate the expansion of inflammatory lesions seen in EtOH/HCl- and aspirin-induced gastritis, LPS/caerulein (CA)-triggered pancreatitis, and acetic acid-induced writhing This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Molecular Nutrition & Food Research 04/2015; DOI:10.1002/mnfr.201400820 · 4.91 Impact Factor
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ABSTRACT: Bittern is made from marine water after extraction of salt, and its major components include magnesium chloride, magnesium sulfate, potassium chloride, sodium chloride and magnesium bromide. For a long time, it has been used as the main ingredient of tofu coagulant and chemical weapons. A 73-year-old woman arrived to the emergency department after a suicide attempt by drinking an unknown amount bittern. She complained of dizziness, general weakness, and altered mental state (Glasgow Coma Scale (GCS) 13/15). The brain computed tomography (CT) and magnetic resonance imaging (MRI) showed no abnormality. But blood chemistry showed hypermagnesemia ([Mg(2+)] 7.8 mEq/L) and hypernatremia ([Na(+)] 149 mEq/L). Electrocardiograph showed QT prolongation of 0.482 s. Electrolyte imbalances were corrected following adequate fluid therapy and injection of calcium gluconate. The patient recovered/was subsequently discharged without any complications. Electrolyte imbalances are a common presentation following bittern poisoning. Severe side effects like respiratory depression, hypotension, arrhythmia, bradycardia, and cardiac arrest can also occur. Patients will require immediate fluid therapy and correction of electrolyte imbalances. The symptoms vary depending on the electrolyte levels. It is mandatory to closely monitor the electrolyte levels and electrocardiograph in these patients.Journal of Emergencies Trauma and Shock 04/2015; 8(2):108-9. DOI:10.4103/0974-2700.145426
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ABSTRACT: Phyllanthus acidus (L.) Skeels (Phyllanthaceae) has traditionally been used to treat gastric trouble, rheumatism, bronchitis, asthma, respiratory disorders, and hepatitis. Despite this widespread use, the pharmacological activities of this plant and their molecular mechanisms are poorly understood. Therefore, we evaluated the immunopharmacological activities of the methanolic extract of the aerial parts of this plant (Pa-ME) and validated its pharmacological targets. Lipopolysaccharide (LPS)-treated macrophages, an HCl/EtOH-induced gastritis model, and an acetic acid-injected capillary permeability mouse model were employed to evaluate the anti-inflammatory activity of Pa-ME. Potentially active anti-inflammatory components of this extract were identified by HPLC. The molecular mechanisms of the anti-inflammatory activity were studied by kinase assays, reporter gene assays, immunoprecipitation analysis, and overexpression of target enzymes. Pa-ME suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and prevented morphological changes in LPS-treated RAW264.7 cells. Moreover, both HCl/EtOH-induced gastric damage and acetic acid-triggered vascular permeability were restored by orally administered Pa-ME. Furthermore, this extract downregulated the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 and reduced the nuclear levels of NF-κB. Signalling events upstream of NF-κB translocation, such as phosphorylation of Src and Syk and formation of Src/Syk signalling complexes, were also inhibited by Pa-ME. The enzymatic activities of Src and Syk were also suppressed by Pa-ME. Moreover, Src-induced and Syk-induced luciferase activity and p85/Akt phosphorylation were also inhibited by Pa-ME. Of the identified flavonoids, kaempferol and quercetin were revealed as partially active anti-inflammatory components in Pa-ME. Pa-ME exerts anti-inflammatory activity in vitro and in vivo by suppressing Src, Syk, and their downstream transcription factor, NF-κB. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.Journal of ethnopharmacology 03/2015; 168. DOI:10.1016/j.jep.2015.03.043 · 2.94 Impact Factor
Article: Development of bilateral gluteal pyomyositis during treatment of acute pyelonephritis in a patient with diabetesThe Korean Journal of Internal Medicine 03/2015; 30(2):256-8. DOI:10.3904/kjim.2015.30.2.256
Article: 3,4-Dihydroxytoluene Inhibits Epidermal Growth Factor-induced Cell Transformation in JB6 P+ Mouse Epidermal Cells by Suppressing Raf-102/2015; 28(1):111-118. DOI:10.9799/ksfan.2015.28.1.111
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ABSTRACT: Graphene, a two-dimensional carbon material, has attracted significant interest for applications in flexible electronics as an alternative transparent electrode to indium tin oxide. However, it still remains a challenge to develop a simple, reproducible, and controllable fabrication technique for producing homogeneous large-scale graphene films and creating uniform patterns with desired shapes at defined positions. Here, we present a simple route to scalable fabrication of flexible transparent graphene electrodes using an oxygen plasma etching technique in a capacitively coupled plasma (CCP) system. Ascorbic acid-assisted chemical reduction enables the large-scale production of graphene with solution-based processability. Oxygen plasma in the CCP system facilitates the reproducible patterning of graphene electrodes, which allows controllable feature sizes and shapes on flexible plastic substrates. The resulting graphene electrode exhibits a high conductivity of 80 S∙cm-1 and a transparency of 76%, and retains excellent flexibility upon hard bending at an angle of ±175° and after repeated bending cycles. A simple LED circuit integrated on the patterned graphene film demonstrates the feasibility of graphene electrodes for use in flexible transparent electrodes.Langmuir 02/2015; 31(9). DOI:10.1021/la504443a · 4.38 Impact Factor
Article: An Effective Post-Filtering Framework for 3-D PET Image Denoising Based on Noise and Sensitivity Characteristics[Show abstract] [Hide abstract]
ABSTRACT: Positron emission tomography (PET) images usually suffer from a noticeable amount of statistical noise. In order to reduce this noise, a post-filtering process is usually adopted. However, the performance of this approach is limited because the denoising process is mostly performed on the basis of the Gaussian random noise. It has been reported that in a PET image reconstructed by the expectation-maximization (EM), the noise variance of each voxel depends on its mean value, unlike in the case of Gaussian noise. In addition, we observe that the variance also varies with the spatial sensitivity distribution in a PET system, which reflects both the solid angle determined by a given scanner geometry and the attenuation information of a scanned object. Thus, if a post-filtering process based on the Gaussian random noise is applied to PET images without consideration of the noise characteristics along with the spatial sensitivity distribution, the spatially variant non-Gaussian noise cannot be reduced effectively. In the proposed framework, to effectively reduce the noise in PET images reconstructed by the 3-D ordinary Poisson ordered subset EM (3-D OP-OSEM), we first denormalize an image according to the sensitivity of each voxel so that the voxel mean value can represent its statistical properties reliably. Based on our observation that each noisy denormalized voxel has a linear relationship between the mean and variance, we try to convert this non-Gaussian noise image to a Gaussian noise image. We then apply a block matching 4-D algorithm that is optimized for noise reduction of the Gaussian noise image, and reconvert and renormalize the result to obtain a final denoised image. Using simulated phantom data and clinical patient data, we demonstrate that the proposed framework can effectively suppress the noise over the whole region of a PET image while minimizing degradation of the image resolution.IEEE Transactions on Nuclear Science 02/2015; 62(1):137-147. DOI:10.1109/TNS.2014.2360176 · 1.46 Impact Factor
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ABSTRACT: A highly enantioselective kinetic resolution of diols via asymmetric acetalization has been achieved using a chiral confined imidodiphosphoric acid catalyst. The reaction is highly efficient for the resolution of tertiary alcohols, giving selectivity factors of up to >300. Remarkably, even in cases where the selectivity factors are only moderate, highly enantioenriched diols are obtained via a stereodivergent resolution to diastereomeric acetals.Journal of the American Chemical Society 01/2015; 137(5). DOI:10.1021/ja512481d · 11.44 Impact Factor
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ABSTRACT: Carpal tunnel syndrome is the most common peripheral entrapment neuropathy. We report on the first Korean case of carpal tunnel syndrome induced by tophaceous deposition in flexor digitorum tendons of a patient with chronic gout. A 63-year-old male suffered from numbness, decreased sensation over both median nerve distribution, and weakness of thenar muscle for 3 years. Physical examinations revealed positive Tinel's sign and Phalen's test and thenar qjmuscle atrophy was found on both hands. In nerve conduction study, there was no action potential of the sensory and motor of the bilateral median nerve. Ultrasonography showed increased cross-sectional area of median nerve due to tophaceous deposition in flexor digitorum tendons in the carpal tunnel. Dual-energy computed tomography showed diffuse multifocal green color coding tophaceous deposition within the carpal tunnel. His neuropathic symptoms improved after injection of triamcinolone into the carpal tunnel and administration of oral medication including non-steroidal anti-inflammatory drugs and colchicine.01/2015; 22(1). DOI:10.4078/jrd.2015.22.1.29
Article: Antiproliferative and Apoptosis-Inducing Activities of 4-Isopropyl-2,6-bis(1-phenylethyl)phenol Isolated from Butanol Fraction of Cordyceps bassiana[Show abstract] [Hide abstract]
ABSTRACT: The Cordyceps species have been widely used for treating various cancer diseases. Although the Cordyceps species have been widely known as an alternative anticancer remedy, which compounds are responsible for their anticancer activity is not fully understood. In this study, therefore, we examined the anticancer activity of 5 isolated compounds derived from the butanol fraction (Cb-BF) of Cordyceps bassiana. For this purpose, several cancer cell lines such as C6 glioma, MDA-MB-231, and A549 cells were employed and details of anticancer mechanism were further investigated. Of 5 compounds isolated by activity-guided fractionation from BF of Cb-EE, KTH-13, and 4-isopropyl-2,6-bis(1-phenylethyl)phenol, Cb-BF was found to be the most potent antiproliferative inhibitor of C6 glioma and MDA-MB-231 cell growth. KTH-13 treatment increased DNA laddering, upregulated the level of Annexin V positive cells, and altered morphological changes of C6 glioma and MDA-MB-231 cells. In addition, KTH-13 increased the levels of caspase 3, caspase 7, and caspase 9 cleaved forms as well as the protein level of Bax but not Bcl-2. It was also found that the phosphorylation of AKT and p85/PI3K was also clearly reduced by KTH-13 exposure. Therefore, our results suggest KTH-13 can act as a potent antiproliferative and apoptosis-inducing component from Cordyceps bassiana, contributing to the anticancer activity of this mushroom.Evidence-based Complementary and Alternative Medicine 01/2015; 2015:739874. DOI:10.1155/2015/739874 · 1.88 Impact Factor
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ABSTRACT: Positron emission tomography (PET) images usually suffer from low spatial resolution mainly because of the finite dimension of crystals. To improve the spatial resolution based on wobble scanning, we previously proposed a sinogram-based super-resolution (SR) algorithm using a space-variant blur matrix. However, the algorithm may cause unwanted resolution loss owing to an inevitable interpolation process for preparing evenly spaced projections. In this article, we propose a novel one-step line of response (LOR)-based SR framework for 3D PET images. In the framework, we efficiently determine a large number of space-variant point spread functions (PSFs) in the image space by using the scanner symmetries and the proposed PSF interpolation scheme based on nonrigid registration. Furthermore, to minimize the resolution degradation in the evenly spaced parallel-beam rebinning and to reduce the computational time in the graphics processing unit (GPU) implementation, we introduce parallel-friendly LOR reconstruction based on cone-beam reordering. We then obtain a high resolution image via a one-step super-resolved 3D PET image reconstruction with the determined PSFs. The proposed framework provides noticeable improvement on the spatial resolution of PET images with a considerable reduction of computational time.IEEE Transactions on Nuclear Science 01/2015; 62(3):1-10. DOI:10.1109/TNS.2015.2421908 · 1.46 Impact Factor
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ABSTRACT: Sn-based thin films as new buffer layer for Cd-free Cu(In,Ga)Se2 (CIGS) solar cells were developed. The Sn(O,S)2 films were formed on CIGS substrates by chemical bath deposition from an alkaline ammonia solution by reacting tin(IV) chloride with thiourea. Optimization of the growth process allowed the smooth and conformal coverage of the films on the CIGS substrates with a thickness of 20 nm that was a self-limited thickness in the chemical bath deposition process. XPS analysis revealed that the as-deposited films contained Sn–O, Sn–OH, and Sn–S bondings and the ratio of Sn–S bonding to Sn–O bonding was 0.3. The CIGS solar cell fabricated with a 20-nm thick Sn(O,S)2 buffer layer had the best efficiency of 11.5% without AR coating. The open circuit voltage, short circuit current, and fill factor were 0.55 V, 34.4 mA/cm2, and FF = 0.61, respectively. The open circuit voltage and fill factor were low compared to the conventional CIGS solar cell with a 50-nm thick CdS buffer due to too thin Sn(O,S)2 buffer layer.Current Applied Physics 12/2014; 14(12):1803-1808. DOI:10.1016/j.cap.2014.10.008 · 2.03 Impact Factor
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ABSTRACT: The combination chemotherapy of irinotecan with 5-fluorouracil and leucovorin (FOLFIRI regimen) was recently proven to be beneficial in patients with advanced colorectal cancer. Pulmonary toxicity is very rare in adverse effects of irinotecan. No case of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia) associated with FOLFIRI chemotherapy has been reported. We experienced a case of a 62-year-old man who presented persistent dry cough and progressive dyspnea after receiving chemotherapy with FOLFIRI regimen. After surgical lung biopsy, the patient was diagnosed with FOLFIRI chemotherapy-induced organizing pneumonia which was successfully treated with steroid therapy.Tuberculosis and Respiratory Diseases 12/2014; 77(6):262-5. DOI:10.4046/trd.2014.77.6.262
Article: Gender Differences in the Effects of Job Control and Demands on Health of Korean Manual Workers.[Show abstract] [Hide abstract]
ABSTRACT: Abstract We used the Job-demand-control model to answer our two research questions concerning the effects of working conditions on self-rated health, and gender differences in the association between these working conditions and health among Korean manual workers. Since the disproportionate representation of women in non-standard work positions is found in many countries including Korea, it is important to examine how working conditions explain gender inequality in health. We used data from the 2008-2009 Korean National Health and Nutrition Examination Survey and analyzed a total sample of 1,482 men and 1,350 women using logistic regression. We found that job control was positively related to self-rated health while both physical and mental job demands were negatively related to self-rated health. We also found significant interaction effects of job demands, control and gender on health. Particularly, female workers' health was more vulnerable to mentally demanding job conditions. Based on these findings, we discussed theoretical and practice implications for future studies.Health Care For Women International 11/2014; DOI:10.1080/07399332.2014.980889 · 0.63 Impact Factor
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