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Publications (223)3281.77 Total impact
Article: Viral Disease Networks[Show abstract] [Hide abstract]
ABSTRACT: Viral infections induce multiple perturbations that spread along the links of the biological networks of the host cells. Understanding the impact of these cascading perturbations requires an exhaustive knowledge of the cellular machinery as well as a systems biology approach that reveals how individual components of the cellular system function together. Here we describe an integrative method that provides a new approach to studying virus-human interactions and its correlations with diseases. Our method involves the combined utilization of protein - protein interactions, protein -- DNA interactions, metabolomics and gene - disease associations to build a ``viraldiseasome''. By solely using high-throughput data, we map well-known viral associated diseases and predict new candidate viral diseases. We use microarray data of virus-infected tissues and patient medical history data to further test the implications of the viral diseasome. We apply this method to Epstein-Barr virus and Human Papillomavirus and shed light into molecular development of viral diseases and disease pathways.Biophysical Journal 01/2010; 98(3). DOI:10.1016/j.bpj.2009.12.1040 · 3.97 Impact Factor
Article: The Landscape ofC. elegans3' UTRs[Show abstract] [Hide abstract]
ABSTRACT: Three-prime untranslated regions (3'UTRs) of metazoan messenger RNAs (mRNAs) contain numerous regulatory elements, yet remain largely uncharacterized. Using polyA capture, 3' rapid amplification of complementary DNA (cDNA) ends, full-length cDNAs, and RNA-seq, we defined ∼26,000 distinct 3'UTRs in Caenorhabditis elegans for ∼85% of the 18,328 experimentally supported protein-coding genes and revised ∼40% of gene models. Alternative 3'UTR isoforms are frequent, often differentially expressed during development. Average 3'UTR length decreases with animal age. Surprisingly, no polyadenylation signal (PAS) was detected for 13% of polyadenylation sites, predominantly among shorter alternative isoforms. Trans-spliced (versus non-trans-spliced) mRNAs possess longer 3'UTRs and frequently contain no PAS or variant PAS. We identified conserved 3'UTR motifs, isoform-specific predicted microRNA target sites, and polyadenylation of most histone genes. Our data reveal a rich complexity of 3'UTRs, both genome-wide and throughout development.Science 01/2010; 329(5990):432-435. DOI:10.2307/40731989 · 31.48 Impact Factor
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ABSTRACT: Physical interactions mediated by proteins are critical for most cellular functions and altogether form a complex macromolecular "interactome" network. Systematic mapping of protein-protein, protein-DNA, protein-RNA, and protein-metabolite interactions at the scale of the whole proteome can advance understanding of interactome networks with applications ranging from single protein functional characterization to discoveries on local and global systems properties. Since the early efforts at mapping protein-protein interactome networks a decade ago, the field has progressed rapidly giving rise to a growing number of interactome maps produced using high-throughput implementations of either binary protein-protein interaction assays or co-complex protein association methods. Although high-throughput methods are often thought to necessarily produce lower quality information than low-throughput experiments, we have recently demonstrated that proteome-scale interactome datasets can be produced with equal or superior quality than that observed in literature-curated datasets derived from large numbers of small-scale experiments. In addition to performing all experimental steps thoroughly and including all necessary controls and quality standards, careful verification of all interacting pairs and validation tests using independent, orthogonal assays are crucial to ensure the release of interactome maps of the highest possible quality. This chapter describes a high-quality, high-throughput binary protein-protein interactome mapping pipeline that includes these features.Methods in enzymology 01/2010; 470:281-315. DOI:10.1016/S0076-6879(10)70012-4 · 2.19 Impact Factor
- Cancer Research 12/2009; 69(23 Supplement):A23-A23. DOI:10.1158/0008-5472.FBCR09-A23 · 9.28 Impact Factor
- Nature Methods 12/2009; DOI:10.1038/nmeth1209-935b · 25.95 Impact Factor
- Nature Methods 12/2009; 6(12). DOI:10.1038/nmeth1209-934 · 25.95 Impact Factor
Article: Zhong, Q. et al. Edgetic perturbation models of human inherited disorders. Mol. Syst. Biol. 5, 321[Show abstract] [Hide abstract]
ABSTRACT: Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as 'nodes' and 'edges', respectively. Better understanding of genotype-to-phenotype relationships in human disease will require modeling of how disease-causing mutations affect systems or interactome properties. Here we investigate how perturbations of interactome networks may differ between complete loss of gene products ('node removal') and interaction-specific or edge-specific ('edgetic') alterations. Global computational analyses of approximately 50,000 known causative mutations in human Mendelian disorders revealed clear separations of mutations probably corresponding to those of node removal versus edgetic perturbations. Experimental characterization of mutant alleles in various disorders identified diverse edgetic interaction profiles of mutant proteins, which correlated with distinct structural properties of disease proteins and disease mechanisms. Edgetic perturbations seem to confer distinct functional consequences from node removal because a large fraction of cases in which a single gene is linked to multiple disorders can be modeled by distinguishing edgetic network perturbations. Edgetic network perturbation models might improve both the understanding of dissemination of disease alleles in human populations and the development of molecular therapeutic strategies.Molecular Systems Biology 11/2009; 5(1):321. DOI:10.1038/msb.2009.80 · 14.10 Impact Factor
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ABSTRACT: The idea that multi-scale dynamic complex systems formed by interacting macromolecules and metabolites, cells, organs and organisms underlie some of the most fundamental aspects of life was proposed by a few visionaries half a century ago. We are witnessing a powerful resurgence of this idea made possible by the availability of nearly complete genome sequences, ever improving gene annotations and interactome network maps, the development of sophisticated informatic and imaging tools, and importantly, the use of engineering and physics concepts such as control and graph theory. Alongside four other fundamental "great ideas" as suggested by Sir Paul Nurse, namely, the gene, the cell, the role of chemistry in biological processes, and evolution by natural selection, systems-level understanding of "What is Life" may materialize as one of the major ideas of biology.FEBS letters 11/2009; 583(24):3891-4. DOI:10.1016/j.febslet.2009.11.024 · 3.34 Impact Factor
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ABSTRACT: Genes and gene products do not function in isolation but within highly interconnected 'interactome' networks, modeled as graphs of nodes and edges representing macromolecules and interactions between them, respectively. We propose to investigate genotype-phenotype associations by methodical use of alleles that lack single interactions, while retaining all others, in contrast to genetic approaches designed to eliminate gene products completely. We describe an integrated strategy based on the reverse yeast two-hybrid system to isolate and characterize such edge-specific, or 'edgetic', alleles. We established a proof of concept with CED-9, a Caenorhabditis elegans BCL2 ortholog. Using ced-9 edgetic alleles, we uncovered a new potential functional link between apoptosis and a centrosomal protein. This approach is amenable to higher throughput and is particularly applicable to interactome network analysis in organisms for which transgenesis is straightforward.Nature Methods 11/2009; 6(11):843-9. DOI:10.1038/nmeth.1394 · 25.95 Impact Factor
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ABSTRACT: Although a highly accurate sequence of the Caenorhabditis elegans genome has been available for 10 years, the exact transcript structures of many of its protein-coding genes remain unsettled. Approximately two-thirds of the ORFeome has been verified reactively by amplifying and cloning computationally predicted transcript models; still a full third of the ORFeome remains experimentally unverified. To fully identify the protein-coding potential of the worm genome including transcripts that may not satisfy existing heuristics for gene prediction, we developed a computational and experimental platform adapting rapid amplification of cDNA ends (RACE) for large-scale structural transcript annotation. We interrogated 2000 unverified protein-coding genes using this platform. We obtained RACE data for approximately two-thirds of the examined transcripts and reconstructed ORF and transcript models for close to 1000 of these. We defined untranslated regions, identified new exons, and redefined previously annotated exons. Our results show that as much as 20% of the C. elegans genome may be incorrectly annotated. Many annotation errors could be corrected proactively with our large-scale RACE platform.Genome Research 10/2009; 19(12):2334-42. DOI:10.1101/gr.098640.109 · 13.85 Impact Factor
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ABSTRACT: Autophagy is a highly regulated self-degradative mechanism required at a basal level for intracellular clearance and recycling of cytoplasmic contents. Upon intracellular pathogen invasion, autophagy can be induced as an innate immune mechanism to control infection. Nevertheless, pathogens have developed strategies to avoid or hijack autophagy for their own benefit. The molecular pathways inducing autophagy in response to infection remain poorly documented. We report here that the engagement of CD46, a ubiquitous human surface receptor able to bind several different pathogens, is sufficient to induce autophagy. CD46-Cyt-1, one of the two C-terminal splice variants of CD46, is linked to the autophagosome formation complex VPS34/Beclin1 via its interaction with the scaffold protein GOPC. Measles virus and group A Streptococcus, two CD46-binding pathogens, induce autophagy through a CD46-Cyt-1/GOPC pathway. Thus, upon microorganism recognition, a cell surface pathogen receptor can directly trigger autophagy, a critical step to control infection.Cell host & microbe 10/2009; 6(4):354-66. DOI:10.1016/j.chom.2009.09.006 · 12.19 Impact Factor
Article: Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins[Show abstract] [Hide abstract]
ABSTRACT: Author Summary Significant diversity exists in protein structure and function, yet certain structural domains are used repeatedly across species to execute similar functions. The SH3 domain is one such common structural domain. It is found in signaling proteins and mediates protein–protein interactions by binding to short peptide sequences generally composed of proline. To investigate both the generality and selectivity of peptide binding by SH3 domains, we examined peptide specificity for almost all SH3 domains encoded within the proteome of the budding yeast, Saccharomyces cerevisiae, using a range of experimental methods. We found that although most of the intrinsic binding specificity for SH3 domains can be summarized by the two previously described canonical binding modes, each individual SH3 domain that we studied utilizes unique features of its cognate ligand to achieve binding selectivity. Moreover, some domains exhibit binding specificities that are distinct from the two canonical classes. We integrated peptide-SH3 domain binding data from three complementary screening techniques using a Bayesian statistical model to generate a protein–protein interaction network for the budding yeast SH3 domain family. This network was highly enriched in endocytosis proteins and their interactions. By examining these interactions in detail, we show that our SH3 domain network can be used to predict the temporal localization of several previously uncharacterized proteins to dynamic complexes that orchestrate the process of endocytosis.PLoS Biology 10/2009; 7(10):e1000218. DOI:10.1371/journal.pbio.1000218 · 11.77 Impact Factor
Article: Multimodal Assessment of Protein Functional Deficiency Supports Pathogenicity of BRCA1 p.V1688del[Show abstract] [Hide abstract]
ABSTRACT: Unequivocal discrimination between neutral variants and deleterious mutations is crucial for appropriate counseling of individuals with a BRCA1 or BRCA2 sequence change. An increasing number of variants of uncertain significance (VUS) are being identified, the unclassified biological effect of which poses clinical concerns. A multifactorial likelihood-based approach recently suggested disease causality for BRCA1 p.V1688del, a VUS recurrent in Italian breast/ovarian cancer families. Whether and how this single amino acid deletion in the BRCA1 COOH terminus (BRCT) domain affects the function of the mutant protein (DeltaValBRCA1) has not been elucidated. We undertook comprehensive functional characterization of DeltaValBRCA1, comprising comparative structural modeling, analysis of protein stability and associations, and analysis of DNA repair function. Our model predicted BRCT domain destabilization and folding disruption caused by BRCA1 p.V1688del. Consistently, the recombinant DeltaValBRCA1 was less stable than wild-type BRCA1 and, unlike the latter, failed to associate with BRIP1, CtIP, and Rap80 and to relocalize to sites of DNA damage. Yeast two-hybrid analysis revealed a compromised interaction with FHL2 and KPNA2, which is likely responsible for improper subcellular localization of DeltaValBRCA1. In addition, we found four new breast/ovarian cancer families of Italian ancestry who carried this sequence alteration. These results provide the first evidence of the effect of BRCA1 p.V1688del on protein stability and function, supporting the view that it is a deleterious mutation. Multimodal analyses like ours could advance understanding of tumor suppression by BRCA1 and ultimately contribute to developing efficient strategies for screening and characterization of VUS.Cancer Research 09/2009; 69(17):7030-7. DOI:10.1158/0008-5472.CAN-09-1440 · 9.28 Impact Factor
Article: Manichaikul, A. et al. Metabolic network analysis integrated with transcript verification for sequenced genomes. Nat. Methods 6, 589-592[Show abstract] [Hide abstract]
ABSTRACT: With sequencing of thousands of organisms completed or in progress, there is a growing need to integrate gene prediction with metabolic network analysis. Using Chlamydomonas reinhardtii as a model, we describe a systems-level methodology bridging metabolic network reconstruction with experimental verification of enzyme encoding open reading frames. Our quantitative and predictive metabolic model and its associated cloned open reading frames provide useful resources for metabolic engineering.Nature Methods 09/2009; 6(8):589-92. DOI:10.1038/nmeth.1348 · 25.95 Impact Factor
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ABSTRACT: In eukaryotic cells the stability and function of many proteins are regulated by the addition of ubiquitin or ubiquitin-like peptides. This process is dependent upon the sequential action of an E1-activating enzyme, an E2-conjugating enzyme, and an E3 ligase. Different combinations of these proteins confer substrate specificity and the form of protein modification. However, combinatorial preferences within ubiquitination networks remain unclear. In this study, yeast two-hybrid (Y2H) screens were combined with true homology modeling methods to generate a high-density map of human E2/E3-RING interactions. These data include 535 experimentally defined novel E2/E3-RING interactions and >1300 E2/E3-RING pairs with more favorable predicted free-energy values than the canonical UBE2L3-CBL complex. The significance of Y2H predictions was assessed by both mutagenesis and functional assays. Significantly, 74/80 (>92%) of Y2H predicted complexes were disrupted by point mutations that inhibit verified E2/E3-RING interactions, and a approximately 93% correlation was observed between Y2H data and the functional activity of E2/E3-RING complexes in vitro. Analysis of the high-density human E2/E3-RING network reveals complex combinatorial interactions and a strong potential for functional redundancy, especially within E2 families that have undergone evolutionary expansion. Finally, a one-step extended human E2/E3-RING network, containing 2644 proteins and 5087 edges, was assembled to provide a resource for future functional investigations.Genome Research 06/2009; 19(10):1905-11. DOI:10.1101/gr.093963.109 · 13.85 Impact Factor
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ABSTRACT: The idea that genes and their products are the fundamental units of biology has profoundly influenced our scientific thinking during the second half of the past century. Today, this reductionism is challenged by a renaissance of a systems understanding of biology, focusing on the systems formed by interacting gene products rather than on individual gene products. This discipline, based on a complementary and more holistic approach, keeps expanding its scope thanks to biotechnological innovations as well as theoretical modeling. This review aims at showing how and why, since the beginning of the 21st century, in fundamental as well as biomedical research, systems biology is proving a promising paradigm for understanding emerging properties of complex biological systems.Medecine sciences: M/S 06/2009; 25(6-7):578-84. DOI:10.1051/medsci/2009256-7578 · 0.52 Impact Factor
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ABSTRACT: "Smart-pooling," in which test reagents are multiplexed in a highly redundant manner, is a promising strategy for achieving high efficiency, sensitivity, and specificity in systems-level projects. However, previous applications relied on low redundancy designs that do not leverage the full potential of smart-pooling, and more powerful theoretical constructions, such as the Shifted Transversal Design (STD), lack experimental validation. Here we evaluate STD smart-pooling in yeast two-hybrid (Y2H) interactome mapping. We employed two STD designs and two established methods to perform ORFeome-wide Y2H screens with 12 baits. We found that STD pooling achieves similar levels of sensitivity and specificity as one-on-one array-based Y2H, while the costs and workloads are divided by three. The screening-sequencing approach is the most cost- and labor-efficient, yet STD identifies about twofold more interactions. Screening-sequencing remains an appropriate method for quickly producing low-coverage interactomes, while STD pooling appears as the method of choice for obtaining maps with higher coverage.Genome Research 06/2009; 19(7):1262-9. DOI:10.1101/gr.090019.108 · 13.85 Impact Factor
Article: Report on EU-USA Workshop: How Systems Biology Can Advance Cancer Research (27 October 2008)[Show abstract] [Hide abstract]
ABSTRACT: The main conclusion is that systems biology approaches can indeed advance cancer research, having already proved successful in a very wide variety of cancer-related areas, and are likely to prove superior to many current research strategies. Major points include: Systems biology and computational approaches can make important contributions to research and development in key clinical aspects of cancer and of cancer treatment, and should be developed for understanding and application to diagnosis, biomarkers, cancer progression, drug development and treatment strategies. Development of new measurement technologies is central to successful systems approaches, and should be strongly encouraged. The systems view of disease combined with these new technologies and novel computational tools will over the next 5-20 years lead to medicine that is predictive, personalized, preventive and participatory (P4 medicine).Major initiatives are in progress to gather extremely wide ranges of data for both somatic and germ-line genetic variations, as well as gene, transcript, protein and metabolite expression profiles that are cancer-relevant. Electronic databases and repositories play a central role to store and analyze these data. These resources need to be developed and sustained. Understanding cellular pathways is crucial in cancer research, and these pathways need to be considered in the context of the progression of cancer at various stages. At all stages of cancer progression, major areas require modelling via systems and developmental biology methods including immune system reactions, angiogenesis and tumour progression.A number of mathematical models of an analytical or computational nature have been developed that can give detailed insights into the dynamics of cancer-relevant systems. These models should be further integrated across multiple levels of biological organization in conjunction with analysis of laboratory and clinical data.Biomarkers represent major tools in determining the presence of cancer, its progression and the responses to treatments. There is a need for sets of high-quality annotated clinical samples, enabling comparisons across different diseases and the quantitative simulation of major pathways leading to biomarker development and analysis of drug effects.Education is recognized as a key component in the success of any systems biology programme, especially for applications to cancer research. It is recognized that a balance needs to be found between the need to be interdisciplinary and the necessity of having extensive specialist knowledge in particular areas.A proposal from this workshop is to explore one or more types of cancer over the full scale of their progression, for example glioblastoma or colon cancer. Such an exemplar project would require all the experimental and computational tools available for the generation and analysis of quantitative data over the entire hierarchy of biological information. These tools and approaches could be mobilized to understand, detect and treat cancerous processes and establish methods applicable across a wide range of cancers.Molecular oncology 03/2009; 3(1):9-17. DOI:10.1016/j.molonc.2008.11.003 · 5.94 Impact Factor
Article: NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Gα[Show abstract] [Hide abstract]
ABSTRACT: The spindle apparatus dictates the plane of cell cleavage, which is critical in the choice between symmetric or asymmetric division. Spindle positioning is controlled by an evolutionarily conserved pathway, which involves LIN-5/GPR-1/2/Galpha in Caenorhabditis elegans, Mud/Pins/Galpha in Drosophila and NuMA/LGN/Galpha in humans. GPR-1/2 and Galpha localize LIN-5 to the cell cortex, which engages dynein and controls the cleavage plane during early mitotic divisions in C. elegans. Here we identify ASPM-1 (abnormal spindle-like, microcephaly-associated) as a novel LIN-5 binding partner. ASPM-1, together with calmodulin (CMD-1), promotes meiotic spindle organization and the accumulation of LIN-5 at meiotic and mitotic spindle poles. Spindle rotation during maternal meiosis is independent of GPR-1/2 and Galpha, yet requires LIN-5, ASPM-1, CMD-1 and dynein. Our data support the existence of two distinct LIN-5 complexes that determine localized dynein function: LIN-5/GPR-1/2/Galpha at the cortex, and LIN-5/ASPM-1/CMD-1 at spindle poles. These functional interactions may be conserved in mammals, with implications for primary microcephaly.Nature Cell Biology 03/2009; 11(3):269-77. DOI:10.1038/ncb1834 · 20.06 Impact Factor
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ABSTRACT: High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments reported in the literature, we found that curation can be error-prone and possibly of lower quality than commonly assumed.Nature Methods 02/2009; 6(1):39-46. DOI:10.1038/nmeth.1284 · 25.95 Impact Factor
Top Journals
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Harvard Medical School
Boston, Massachusetts, United States
- • Department of Genetics
- • Department of Biological Chemistry and Molecular Pharmacology
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
- • Center for Cancer Systems Biology
- • Department of Cancer Biology
Harvard UniversityCambridge, Massachusetts, United States
Chalmers University of Technology
Goeteborg, Västra Götaland, Sweden
- Department of Chemical and Biological Engineering
Boston Children's HospitalBoston, Massachusetts, United States
National Human Genome Research InstituteMaryland, United States
Centre for Cancer BiologyTarndarnya, South Australia, Australia
University of Leeds
Leeds, ENG, United Kingdom
- School of Biology
The Rockefeller UniversityNew York, New York, United States
Enanta PharmaceuticalsWatertown, Massachusetts, United States
Massachusetts General HospitalBoston, Massachusetts, United States


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Published: Monday, July 24, 2006 at 12:30 a.m.
Last Modified: Monday, July 24, 2006 at 12:00 a.m.
Barbara Teague of Lexington and David Teague of China Grove announce the engagement of their daughter, Megan Elizabeth Teague, to Adam Duane Meredith, son of Kenny Meredith and Vicki Meredith, both of Winston-Salem.
An Oct. 7 wedding is planned at Center United Methodist Church.
Miss Teague is a 2002 graduate of North Davidson High School and a 2005 graduate of Cabarrus College of Health Sciences. She is a registered nurse at Northeast Medical Center in Concord.
Mr. Meredith is a 2000 graduate of North Davidson High School and served four years in the U.S. Navy. He is employed by Fire Ade Inc. in Winston-Salem.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.
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Labrador 3/4 Sleeve Top
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This comfortable top features a v-neck, ¾ sleeves, and an adorable Labrador with a leash in his mouth. Looks like somebody's ready to go for a walk! Pair it with jeans for a casual look, or dress it up with a printed skirt.
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Embassy Suites Fort Myers
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... Whilst on our way we encountered a terrific thunderstorm overhead which made us both jump! We arrived at Steve and Norma's house around 5pm. It took us approximately two hours but with Norma's excellent directions we did not have to do any U turns! I met Steve and Norma two years ago on a cruise to St Petersburg. They made us very welcome, and after dinner we had a very nice evening in the pool with wine of ...
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Castle Lanikai Resort
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Kauai - The Garden Island
... its claim to fame in the 1950's when it featured in the Elvis Presley film 'Blue Hawaii'. Not that you would know it, when we watched the start of the film the same beach is still as unspoilt and natural as it was over 60 ago which only reiterates our point that Kauai is a rare underdeveloped paradise on our ever expanding world.
Lydgate Beach Park was the closest beach to home and ...
My 38th birthday in paradise
... even more.
After our flight we were invited to join Michelle & Serafin for cocktails and watch the sunset at a beach bar on the South Shore. It was the perfect end to our helicopter flight and couple of days celebrating my birthday. We were on a high from the flight (not from one of Serafin's joints!) and thanks to staying off the 'home grown', it was a birthday I will never forget!
Girls day out
... made Ahi tuna salad, purple sweet potato salad and fresh beets. Next was Hanalei Coffee Roasters for our morning caffeine fix (or in Lauren's case, decaf but it still makes her get the jitters!). We then made our way to the end of the road. No really, the road around Kauai ends on the north shore - it's too marshy to build a complete loop around the island. We stopped off at a bunch of scenic overlooks and a few absolutely stunning beaches. Our ...
Soaring Like Eagles (1980)
... br>
"If you don't run fast, your life won't last, and she'll cook ya 'til you're done."
"Jump, jump, jump, ya gotta get over that hump."
"If you don't jump high, and hit the sky, you'll end up with a lump."
After several more verses, we buckle over in uncontrollable laughter.
"This is too funny!" ...
Sun is shining finally ....... Life is a beach
... friendlier than what we encountered on Oahu. Life is much slower and relaxed. A great place for a holiday. Drove to St Regis Resort - the only five star resort on the island - to view the sunset. Valet parked the car and walked into the resort as if we owned it. Joined the crowd on the balcony overlooking Hanalei Bay. Ordered drinks and cheese platter and simply watched the world go by. A wonderful night in a beautiful setting. Another amazing night on ...


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Written on: 03/08/2015 by JAHarlan (1 review written)
I couldn't be any happier being a member of Chesapeake's ILKB! The owners and instructors are so positive, encouraging and knowledgeable. The workouts are intense but awesome! You will certainly sweat like crazy but even if you walk away with your muscles aching, you will want to come back for more. Another unexpected benefit to joining ILKB is the connections and friendships you will form with other members. As a full-time working mother of three, I rarely do things outside of work and… Read Full Review
Written on: 01/08/2015 by suzannwest (1 review written)
Amazing Atmosphere and Amazing Instructors. I absolutely love this place… Read Full Review
Written on: 31/07/2015 by michelezlandry (1 review written)
ILoveKickBoxing Randolph is no doubt the best full body workout you can get in an hour. The staff are super motivational. The other members are supportive and no one judges you. I was surprised at the range of age and fitness levels of the other members. Anyone can do this. It is simple but not easy. This program always makes my day better..great workout! Nobody makes you feel like you have to do more than you can handle, but they also push you to your limits so you get the results you want… Read Full Review
Written on: 30/07/2015 by kasiemorton-nespor (1 review written)
The place will get you into shape quick and it kicks your butt but it's so much fun and the energy is so high and positive that you forget your working out and doing something good for you and your body… Read Full Review
Written on: 30/07/2015 by CheryllynnR (1 review written)
Clean! Friendly instructors no matter the fitness level you have they will help modify the class so you get the most out of the class. They motivate you and help keep you on track! I have highly recommended this class to my friends and family! Cheryl R… Read Full Review
Written on: 30/07/2015 by stephaniebass (1 review written)
This is the place to feel the burn and the love. The Saugus Location is the best. Best staff best workout! Go, go now… Read Full Review
Written on: 30/07/2015 by tamicka (1 review written)
This is the best workout you can ever have, it was the best decision I ever made great environment, friendly staff and clean workout area… Read Full Review
Written on: 30/07/2015 by CMissler (1 review written)
I have been going to classes now for about three weeks and I can see and feel the results! It is an amazing workout and tons of fun. The facility is awesome and the staff is even better! I would highly recommend to anyone who is looking for a fun way to get fit. … Read Full Review
Written on: 30/07/2015 by amyfaisongallashaw (2 reviews written)
This is by far the best workout I've ever had. I knew after the first class i wanted to continue this workout. The people that work here will keep you motivated throughout the whole workout. Honestly I didn't think i could last the whole class but they really help you get through it. Confidence building at its finest. They Rock!… Read Full Review
Written on: 30/07/2015 by amyfaisongallashaw (2 reviews written)
This is by far the best workout I've ever had. I knew after the first class i wanted to continue this workout. The people that work here will keep you motivated throughout the whole workout. Honestly I didn't think i could last the whole class but they really help you get through it. Confidence building at its finest. They Rock!… Read Full Review
Written on: 30/07/2015 by lisaluck (1 review written)
I have been to many gyms over the past 15 years. In the beginning they are all about making you feel good, but after the first couple of weeks you just blend into the walls with everyone else. I always get on a good kick with the gym and then end up bored after a few months because it is basically the same workout day in and day out. I reached a point AGAIN where I was bored with my current gym situation. An new gym named, ILoveKickBoxing.com opended up right across the street from me so I… Read Full Review
Written on: 29/07/2015 by hmlevy714 (1 review written)
ILKB is an amazing place! the workout is out of this world and the trainers WILL NOT let you fail. you show up, bust your butt and watch yourself succeed!!!!! I cannot speak highly enough of ILKB. I was so scared when I signed up at first for my first class, leaving there, I signed up for a year!! That should tell you something!!!!! its amazing!!!!!… Read Full Review
Written on: 28/07/2015
One of my favorite things about this gym is how the trainers motivate you! They push you to be your best and don't make any assumptions. The classes are fast paced and absolutely great when you need to let off some steam. They're open to all levels of fitness and it's always a full body workout with lots of positive energy. There's tons of parking, super nice trainers, and super nice classmates. They have a small store in the front with anything you might need for class. There are locker rooms… Read Full Review
Written on: 28/07/2015 by rose27ann (1 review written)
Great place wonderful people good work out really gets you blood flowing before you know it the hr is done and it doesn't seem like… Read Full Review
Written on: 26/07/2015 by Andrew2015 (1 review written)
I always look forward to the next class mostly because of the people. The instructors are friendly and driven - these qualities come onto all the other people as well to make for a pleasant atmosphere. The workouts are tough yet anybody can set their own pace relative to their needs. The staff take very good care of the place and it is always clean and looking good. I leave satisfied at the end of the day and that motivates me to come back regularly - critical for achieving the best success in… Read Full Review
Written on: 25/07/2015 by B.Gonzo (1 review written)
Signed up for a trial membership and by my second class had to be a member. All the staff are incredibly kind and knowledgeable. Within the first 10 minutes of class we were sweating up a storm. Great atmosphere and good people… Read Full Review
Written on: 25/07/2015 by kassilockwood (1 review written)
This place is great!! When I signed up for my first class I was afraid because I knew I was really out of shape. But as soon as I walked in the front door I got all smiles and amazing energy and was not afraid anymore. All the instructors are GREAT. I have a bad ankle and they work with me to do some of the moves different if I need it. I always come out with my shirt soaked in sweat and feeling really good about myself. I LOVE IT!! never thought I would say that… Read Full Review
Written on: 24/07/2015 by Karenyaz (1 review written)
Ilovekickboxing Vaughan is amazing! This is by far the best workout I have ever had! The staff is amazing and the workouts are intense but so much fun. I have seen results immediately and look forward to each session. Becoming a member was the best decision I made!… Read Full Review
Written on: 17/07/2015 by LAFrench (1 review written)
I'm a beginner and was welcomed from the very start. Staff were friendly, tough yet patient with ensuring both myself and the other patrons are accurately completing the moves, the music is AWESOME, the WORKOUT IS INTENSE, but welcoming on all levels. my only regret is that I didn't start sooner. would highly recommend it to anyone looking to burn off some calories or simply GET THE HEART PUMPING!… Read Full Review
Written on: 17/07/2015 by robins695 (1 review written)
Ok as an athlete and a pretty active person I am always looking for great, new and different ways to get and stay in shape. The experience that I have had at ILKB is nothing short of amazing! Like most I purchased the web special for my trial, patiently waited for my call to set up my first class; along with over 2000 others; got my call set up my first class and in I came. The instructors and staff were extremely welcoming even though there were a TON of people there. We had an intro… Read Full Review
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Miami Beach Has Banned Plastic Straws
Sorry sippers, Miami Beach has banned plastic straws from the beach. Yes, to cut down on litter on the beach, the city commission amended an ordinance last week that could result in fines of $50 to $500 over straws. Don't worry though, the ban is aimed at beachfront hotels who serve drinks with straws, and you're still free to use straws in whatever legal ways you please. Just make sure you dispose of them properly.
The ban is now just waiting for the mayor's signature.
Local 10 reports that dozens and dozens of straws a day are left behind on the beach. The plastic tubes aren't biodegradable, and are usually too small to be caught by beach sifters. They also present a threat to marine life if they drift into the ocean.
Though, areas of the beach in front of private condominiums and parks (like the area between Fifth and 15th Streets) tend to be straw-free. The biggest offenders are tourists who order drinks on the beach directly from their hotels. So the commission has reached out to hotels to inform them of the new ban.
"It is a huge burden on our ecological systems. So, people may say this is sort of silly, 'Big deal, you're banning straws.' But at the end of the day, we're taking a step in the right direction to leave a better world for our children. To make sure our environment, our ecology, is better off for it," Commissioner Jorge Exposito told Local 10.
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By Catholic Online (NEWS CONSORTIUM)
7/9/2013 (2 years ago)
Catholic Online (www.catholic.org)
Congress is taking measures to protect American security where Obama won't. Congressional committees are delaying the delivery of arms to the Syrian rebels amid concerns they could end up in the hands of Jihadists and militant Islamists, and be subsequently used against Christians, Jews, and other allies.
By Catholic Online (NEWS CONSORTIUM)
Catholic Online (www.catholic.org)
7/9/2013 (2 years ago)
Published in Middle East
Keywords: Congress, weapons, Syria, Obama, aid
LOS ANGELES, CA (Catholic Online) - Intelligence committees in both the House and Senate have stalled planned shipments of military hardware to Syrian rebels and none of the equipment promised weeks ago has yet arrived.
Several al Qaeda affiliated groups have been identified fighting alongside the Free Syrian Army, and Congressional leaders want to see that weapons will not end up in the hands of terrorists. Committee members say that want more information on Obama's plans to arm these groups and what safeguards he intends to take.
They also want to know if the weapons will truly make a difference as Assad makes new gains against the rebels.
The committees have stopped the shipments by withholding funding.
While Obama does have the power to authorize the shipments, tradition remains strong, and a tacit agreement between Congress and the Oval Office says that shipments will not be delivered if one or more intelligence committees have a serious reservation about them.
The Obama administration noted when it promised the weapons that their shipment was contingent upon consultations with the committees.
Both John Kerry and the CIA have addressed the committees, saying that Assad has used chemical weapons and crossed a red line established by the administration. However, Congress remains worried that the weapons could end up in the hands of terrorists. The Obama administration is yet to satisfactorily address these concerns.
So far over 100,000 people have been killed by fighting in Syria. Many of those dead have been civilians killed in indiscriminate attacks as well as many killed in targeted attacks by both rebels and regime supporters.
Recently, it has become widely recognized that al Qaeda-friendly elements have started persecuting Christians in the region. Christians were relatively unmolested by the Assad regime, and have managed to remain neutral throughout the struggle. This has prompted accusations of collaboration by extremists.
Rebels have attacked Christian churches and martyred clerics in recent weeks.
It is unknown if U.S. aid will now be sent to Syria, and it appears as though the conflict will continue for the indefinite future.
The Rosary
St Patrick Rosary
By Nikky Andres (NEWS CONSORTIUM)
Australian public broadcaster, SBS defended the reality show where participants were shot at by ISIS militants in Syria. The incident was said to be a part of a trip retracing refugees' journeys and that those involved had wide security provisions. MUNTINLUPA, ... continue reading
By Nikky Andres (NEWS CONSORTIUM)
A suspected ISIS recruitment document discovered in Pakistan's anarchic tribal lands revealed that the religious extremist group has ostentatious ambitions of building a new terrorist army in Afghanistan and Pakistan, in addition to triggering a war in India to provoke ... continue reading
By Catholic Online (NEWS CONSORTIUM)
One of the greatest casualties of war is displaced civilian populations left without the necessities of life. In Yemen, nearly 4,000 people have been killed with more than 1.2 million people displaced. On ongoing battle between Houthi rebels and forces loyal to exiled ... continue reading
By Linky C. (NEWS CONSORTIUM)
A total of $150 billion is estimated to be the amount Iran will receive from the Iran deal. This amount will provide the country more than the $124.3 billion the U.S. has given to Israel in total financial aid since 1948. MUNTINLUPA CITY, PHILIPPINES (Catholic Online) ... continue reading
By Catholic Online (NEWS CONSORTIUM)
It was a shocking incident that drew attention to the plight of millions of refugees living in host countries. Thirteen-year-old Ahmet Hamdo, whose large Syrian family fled the war-torn town of Aleppo, was beaten mercilessly by a Turkish restaurant owner for selling ... continue reading
By Nikky Andres (NEWS CONSORTIUM)
Abu Bakr al-Baghdadi personally sanctioned a women to be beheaded, as a wedding present to a brutal female "judge" in the terror group's feared religious police. The cruel woman asked to slaughter an unbelieving "infidel" in return for taking a new husband after the ... continue reading
By Catholic Online (NEWS CONSORTIUM)
Australian authorities have clamped down a misguided attempt at heroism. Jamie Reece Williams, from suburban Melbourne was arrested after he allegedly try to fly to northern Iraq to join Kurdish forces battling Islamic State. It remains illegal for any Australian to ... continue reading
By Catholic Online (NEWS CONSORTIUM)
He was at one time the most visible and dreaded figure in the Islamic State terror group . now, "Jihadi John" has fled for his life, afraid that his ISIS overlords were planning to kill him with as much leniency mercy as he did captive journalists. LOS ANGELES, ... continue reading
By Catholic Online (NEWS CONSORTIUM)
In what appears to be their favored method of execution for those accused of homosexuality, ISIS agents tied the hands of two men behind their back and then pushed them off a rooftop to their deaths in Homs, Syria. The jihadis blindfold the men before standing ... continue reading
By Kevin J. Jones, CNA/EWTN News
One year after an outbreak of violence between the Israeli military and Hamas militants in Gaza, Catholic Relief Services is helping conflict victims to find new homes. Gaza City (CNA/EWTN News) - "It's hard to believe it's been a year already. Unfortunately, it ... continue reading


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The Which Goonie Are You? Test
Mouth and Mikey
All possible test results
New Age Goonie
You are your own Goonie! Many strive to act like their fave from the beloved movie, but not you! I would like to congratulate you on your independance from the sway that Mickey, Mouth, Data and Chunk ... Read more
Your super sniffer will always tell you the best way to go to get the food you so desperately love! Whether you crave ice cream, candy bars or simply pizza you will always have friends, old or new, to... Read more
You not only speak your own langauge, but you walk your own walk! You've never let your toung get in the way of showing off your great inventions and impressing all who see! However, when you make a m... Read more
Data & Chunk
Super sniffer and super smarts? What more could a Goonie ask for?! Read more
You are the leader, the foundation of the Goonie house...in fact you own the Goonie house! When your friends are in trouble they know they can come to you, and they do. You are always there and you al... Read more
Mikey & Chunk
You are both a great leader and a loyal follower. The best a friend could ever ask for! Read more
Mikey & Data
You have the smarts and the leadership skills to become something great! Good luck and "don't slip!" Read more
Mikey, Data & Chunk
Wow! Leadership, smarts and loyalty! Have you ever thought about military intelligence? Read more
No matter what someone may say to you, you always have the perfect words to throw back (unless it happens to be your secret crush)! You have been given the gift of toung...use it wisely. It can hurt a... Read more
Mouth & Chunk
Quick-witted sarcasm and true devotion never went well together. You constantly are shooting yourself in the foot around the ones you love the most. Better learn to control that mouth of yours! Read more
Mouth & Data
Sarcasm and smarts. Are you an IT person? Read more
Mouth, Data & Chunk
What a combination...that's all I have to say... Read more
Mouth and Mikey
I hope you're never my boss! Read more
Mouth, Mikey & Chunk
Yikes! Read more
Mouth, Mikey & Data
Indiana Jones watch out! Read more
Super Goonie!
Unfortunately, noone could ever really get this catagory, so I'm even going to write anything cool in it. If something goes wrong and you do get this, please let me know! Read more
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Happy Easter Live Wallpaper by Wallpaper by Paul Whatever your wallpaper, with the mood of Easter eggs and holidays. Easter eggs - specially dyed or painted eggs for Ea … 1,000+ downloads, Rating 4.75 (48) Free
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Hello Everyone!
This time, we will be traveling to San Jose to meet some small and self-owned businesses there. Join us in networking and creating real leads for each other.
Please also plan on spending at least $5.00 for a drink.
I look forward to seeing everyone!
To get ahead, sign up on our website so you can refer leads to each other! http://mvsb.levleymarketing.com/
0 · October 10, 2013
Would anyone be interested in carpooling from Palo Alto?
0 · September 29, 2013
Sorry, I have a scheduling conflict. Thursday are not a good day for me.
0 · September 19, 2013
I started the group because there wasn't any other type of group like this. I've met some great folks in the group who have become close friends and have also met some amazing business owners.
— Bill, started New York City Gay Craft Beer Lovers
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Interim engineer intern jobs1 Jobs
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- Student Employee - PDU - Engineer Performs engineering and scientific analysis connected to research in energy storage, distributed generation, and microgrids. Works directly withElectric Power Research Institute, Inc.3.2 69 Reviews Electric Power Research Institute, Inc.Palo Alto, CA30+ daysSave
Hiring? Post a Job


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Gospel Christian Music Showcase-Bless The Mic Elyon Part 2 - Music Videos
Embed niva1 312 views 2013-02-04T23:04:19 Enjoy another evening of live music highlights from the Elyon Bless the Mic Talent Showcase and open mic at the Sisters of Soul Cuisine in Linden New Jersey. There is some talent that blesses the mic here that is better than on the radio and television. Stay tuned for more video footage featuring our reggae artist and comedians.
For more information go to Bless The Mic Magazine online and/or facebook Kamal Imani
For more information go to Bless The Mic Magazine online and/or facebook Kamal Imani
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huma qureshi
archery games
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Looks like you are on slow connection. Please download video below.
Oye Oye Song ringtone from Double Dhamal
2 yrs ago - Nokia N95
Nice ringtone.


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Will Chicago Cubs Give Up On Travis Wood?
Chicago Cubs pitcher Travis Wood finished the 2012 MLB season as a starting pitcher. In his last seven starts, Wood pitched three quality starts and a 3.07 ERA, and was within one out of two more quality starts. He finished the season with a 6-13 record, 4.27 ERA and 1.20 WHIP.
Was that enough to win a spot in the 2013 Opening Day starting rotation? Wood earned praise from manager Dale Sveum, who suggested that Wood would keep his starting gig in 2013. However, after management added four starting pitchers this offseason, Wood's future will depend on how he pitches in March.
Matt Garza, Jeff Samardzija and Edwin Jackson are locks to make the starting rotation. These pitchers either have too much upside or money invested into them. General manager Jed Hoyer promised Scott Feldman a starting job. Slot him in at No. 4 or No. 5.
Barring injuries, trades or broken promises, that's four-fifths of the rotation. That leaves Scott Baker, Carlos Villanueva and Wood fighting for the last spot. Baker and Villanueva both signed contracts this offseason. Baker signed a one-year, $5.5 million deal, while Villanueva signed a two-year, $10 million deal.
It's hard to see Baker getting left out of the mix. 159 of his 163 career appearances have been starts. When free agency started, Villanueva wanted a team to promise him 30 starts. How would either of these pitchers respond if they're used as spot starters or middle relievers?
Moving Wood to the bullpen doesn't make much sense. Why give up on one of the pitchers with the most upside? Wood also gives them a southpaw. Are the Cubs comfortable with five right-handed starting pitchers?
Will these pitchers rotate from the bullpen to the starting rotation? That never worked for Samardzija, who struggled when he didn't have a clear role. Furthermore, Hoyer suggested that Feldman's struggles were because he was always looking over his shoulder with the Texas Rangers.
After spring training, Sveum has some interesting decisions to make. It becomes even more interesting if everyone pitches well. One or two of these pitchers are bound to feel lied too. Will they remain professional about a demotion? If word gets out that management lied to these free agents, could that affect the franchise's ability to sign players down the road?
One thing is for certain: Wood had better come out of March and April pitching very well. His job as a starting pitcher depends on it.
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Saturday, 25 July 2015
This blog entry records the last of the Scandinavian holiday snaps. Above is a snapshot of the beach of the 'Swimming Lake' near Nea's farm house. This area of the beach seems to be covered with clover flowers, which, in the sand, give a rather pretty effect.
And, finally, the long journey home. Ruth drove us back across Sweden and Norway to Trondheim Airport. The girls came, too. Above snap shows Swedish mountainous area, with glimpses of snow towards the tops.
Fairly typical North west Swedish Church, with separate bell chamber.
Nea driving into Norway. The journey was fairly uneventful.
Thank you, Nea, Lasse, and family, for a lovely break in a lovely country. The time flew past.
Normal Service will now be resumed :-
This past week has been busy. Our good friend Hilary has had an eye operation. Ann ran her into hospital, stayed with her, and stayed overnight with her on her return home. At the same time I took a taxi, then a train into London, viewed Bonham's Arms and Armour auction then slept at Lizzie's. On Thursday, back to Bonham's and bid (fairly successfully - seven lots). Then home by train, etc. Got home about 9p.m.
Yesterday (Friday) evening, friends Hilary and Heather, came and had supper with us-thoroughly enjoyed the evening, ate early (6.30p.m. for seven) in view of Hilary's op. earlier in the week. Party broke up about nine thirty p.m. so an early night (much needed). Slept well.
Posted by Mike and Ann at 11:19 1 comment:
Tuesday, 21 July 2015
To return to mid/North Sweden. The area where Nea lives is, in fact, about a hundred miles South of the arctic Circle. On a map it looks like North/Central Sweden, but is treated by the natives as being in Northern Sweden. On the photo above is part of a lilac hedge near their farmhouse. We saw several of these, although lilac in full flower seemed strange to our eyes in mid July.
The picture above is taken from the top of what looks like a modern water tower. On top of it is a circular glazed area which contains a very good restaurant (we lunched here three days of our stay- and excellent grub it was, too). We had a window seat looking over the town, the lake, and the surrounding hills. The lake is huge -several miles long. According to local legend it contains 'the Great Lake monster' . He appears to be something like our 'Nessie'. Animal activity was last observed in the waters of the lake about two years ago.
Back at the farmhouse, our granddaughters and Nippa, the dog, soaking up the sunshine on the front porch.Should say the young lady on the right is now exactly the same height as I am (or slightly taller), whilst her sister, on the left, is an easy three inches taller than I am, i.e. about six foot two.
One day we drove out to 'the Swimming Lake'. It's a smaller lake (about two miles long) with a beach at one end. We didn't swim (the first year there we haven't, but it was tooooo cold). In a field near the lake I photographed these three cranes, large birds, about three feet high at the shoulder.
I think we're nearly at the end of the holiday snaps; one more blog entry should do it. Grit your teeth. Then it's back to the usual Suffolk scenery.
Hope you haven't been too bored, Regards, Mike and Ann.
Posted by Mike and Ann at 17:24 4 comments:
Monday, 20 July 2015
On our second day in Sweden we drove out to Nea's farm. The above photo shows the river (stream really) which flows about seventy yards from the farmhouse. As it had rained a good deal in the previous week the river was in spate. This little river supplies the water for their farmhouse and all the other houses in the village (all five of them). Good clean water it is too!
This one is of Nippa, the family dog. She is, as you can see, a pure bred Norbotten Spitz (or so I'm told). She is, I think the best natured and most intelligent dog I've ever known. She is now, though, eleven and a half years old. She is trained to the gun, and assists Nea's husband when he's out after elk.
Not sure if these are wild roses, although there are several banks of them in the area. For a 'single' rose they have a lovely scent.
The above small building was originally the calf shed. When Nea and husband bought the place, they turned it into a play house for their daughters, who at nearly eighteen and fifteen have rather grown out of it now. There are two swings from the cross bar (a pine tree trunk) in the two silver birch trees, and the swings are still in occasional use.
It is a lovely, peaceful part of the world.
Good night all.
Posted by Mike and Ann at 21:37 1 comment:
Sunday, 19 July 2015
These two extra photographs are for the benefit of Crowbard and Rog (or indeed any of my readers who care to take a guess at last Friday's mystery object.
I think they will help to identify the object's primary purpose, although it is rather a rarity - not the sort of thing you'd expect to find at a car boot sale these days; nor the sort of thing that any jack of all trades would use.
Hope this helps.
Regards, Mike and Ann.
Posted by Mike and Ann at 20:32 7 comments:
Saturday, 18 July 2015
As you can see the above photo is of the first railway station out of Trondheim. It is called Hell, whichof cours, gives rise to all sorts of terrible puns, i.e 'We had to go through Hell to get to Trondheim'.........'It's a Hell of a long way to get to Trondheim'.........etc, etc,etc. I do wish Rog or someone like him who's good at thinking of fresh puns would go to ..... NO, I must reword that ..... Oh well, I'm sure you know what I mean, Rog, although I'm not sure there are any new ones. I asked my youngest granddaughter (who is fifteen) about the name of the place, and she tells me that she thinks that in Norwegian it probably means a large, rocky shelf, presumably on which the village was built.
Above demonstrates the result of prolonged travelling, although I think ten minutes or so did her good. Ann is one of those fortunate people who can drop off for fifteen minutes, then wake refreshed. If I do that I tend to sleep soundly for an hour or more, then wake feeling worse than when I dropped off !
This was taken somewhere near the Swedish/Norwegian border. If you look at the upper part of the picture it shows that, even in July, it's possible to see snow in this area.
More to come - but probably tomorrow, although tomorrow looks like being a busy day. Good night - we'll see.
Posted by Mike and Ann at 17:28 3 comments:
On the evening of Wednesday the eighth of July we flew to Norway (Trondheim airport), and met up with our daughter and her daughters. We slept at the Airport Hotel, then spent the next morning exploring the town of Trondheim. It's a nice old town (I think an old fishing port) and is an excellent place for pottering around.
In the afternoon we caught the train from Trondheim to Ostersund in Sweden. The above photo was taken from the train a mile or two from Trondheim, and is of the fjord. There is more to come, but the machine refuses to accept more that three photos at a time, so I am having to publish this in little bits.
Posted by Mike and Ann at 17:01 No comments:
Friday, 17 July 2015
Just after midday today we arrived back in civilisation (well Suffolk anyway) after our trip to Sweden via Norway - Trondheim Airfield. The trip was organised by our second daughter (who blogs as Nea) and Ann. We stayed with Nea and her husband, her 15 and (very nearly) 18 year old daughters. I have a lot of holiday snaps to foist on my readers eventually; but in the meantime here are some photos of an antique object I purchased whilst in Sweden. I think it will make a very decent MYSTERY OBJECT, in that I shall be pleasantly surprised if any of you can guess its correct (well - primary - purpose). It is made of wood (I think straight grained mahogany), and is just over ten and a half inches long. See if you can tell me its purpose, date and country of origin. In view of where I purchased it the country of origin should be Sweden, but even that is a little doubtful in that the only illustration I can find of a similar one states that it was made in England!
I will eventually publish more photoes to illustrate its purpose. It is lovely to be home, and I wish you very happy guessing.
Warm regards - Mike and Ann.
Posted by Mike and Ann at 15:42 6 comments:
Tuesday, 7 July 2015
The garden gate, entwined with honeysuckle and columbine.
Last year we put this blue-ish, spiky plant into the herb garden. It's doing very nicely thank you, but we can't remember what it is - or even if it's a herb. If anyone can assist identification we'd be grateful. In fact -all contributions (or suggestions) gratefully received.
Got a fairly hectic few days coming up, but will indulge in further bloggery as soon as we have time to spare.
Warm regards to all. Mike and Ann.
Posted by Mike and Ann at 14:43 6 comments:
Sunday, 5 July 2015
Today, after morning service, we motored over to the Quy Mill Hotel in Cambridgeshire, To celebrate Ann's brother Mick's eightieth birthday, which occurs on this coming Tuesday. Mick had hired two large rooms and an area (with table and chairs) of the river bank outside. Above you see a photo of Ann and meself about to dig in.
The photo above shows the birthday Boy dealing faithfully with a pork pie.
The rest of the photos show the guests, about a hundred people, all family or old friends, and family friends. All are members of Norfolk families, largely Claytons, Eglingtons, and a handful of Horners. All were having to recognise old friends, distant cousins not seen for years, having to remember their names, strike up a conversation (or continue one abandoned several decades ago) and make themselves heard over the hubbub of a hundred East Anglians (mainly Norfolk folk) all competing to be heard. As I am known to be deaf I didn't have to compete to be heard, so could get on with enjoying the grub and bubbly, although poor Ann had to field off the more determined enquiries, or gain my attention (usually by hacking my shins under the table) to answer questions. One of the more interesting ones was how old did a clock have to be to be worthy of the attention of an antiquarian horologist (i.e. ME). We started off with the assertion that the clock which needed attention was of first world war date and therefore had to be a bona fide antique. I pooh-poohed that one and fought the date backward to the Napoleonic wars, refusing to be interested in anything much after that date. I find it pays to be firm, especially with old acquaintances, and distant relations, who will then argue on much the same terms what is considered to be a reasonably fair fee within a family. This discussion was enjoyed by all, not least me.
Needless to say, a thoroughly good time was had by all of us. In the normal way of things this sort of family get-together-discussion and exchange of news, only takes place immediately after funerals, so it was good to enjoy each other's company at something as cheerful as an eightieth birthday celebration. I don't suppose anyone reads 'Tom Brown's Schooldays' nowadays, but I seem to remember, somewhere in the early chapters, Thomas Hughes describing how 'the old Browns' enjoyed a good argumentative discussion at just such a family get-together. People don't alter much over the centuries, do they?
Good night all.
Posted by Mike and Ann at 21:29 7 comments:
Tuesday, 30 June 2015
This picture shows your blogger with the gun clipped to his belt, and folded so the whole weight hangs below the belt. I got a bit muddled when putting this blog entry together. Pictures four and three go together, and show the gun, straight, hanging from my belt, then covered by my raincoat; the whole thing looking (and feeling) very bulky, with only the top button done up.
Pictures two and five, showing the gun folded (2) and clipped to my belt; and then with the gun in the same position with my raincoat over it, completely buttoned. It works well, and as Crowbard remarks, it only works well when supported by the belt hook, and the gun folded.
Thank you, gentlemen, it's always interesting to experiment with these devices, and find out how they were meant to work; during the (usually) short time that they are in my possession.
Posted by Mike and Ann at 18:05 4 comments:
Monday, 29 June 2015
The blunderbuss illustrated above is one I bought last week. It is not, in one sense, a 'mystery object'. But there is one feature of it that I do not really understand.
And that is the fact that, as you can see, it fold in the middle. I have seen this feature before in Italian guns; but in the sixty years I have been collecting antique guns, this is the first gun with this feature that I have ever owned.
Here is a close-up of the wrist of the gun. The button on top of the wrist is pressed and the gun folds up like a Japanese Sumo wrestler struck smartly in the solar plexus by a bigger rival.
This picture shows the other slightly unusual feature - the elliptical muzzle; but I can see the advantage of this:- if you are being charged by a straight line of criminally inclined miscreants, then the gun, instead of throwing the circle of bullets that a round muzzle would give, presumably would throw a longer horizontal pattern, and bring down more wrong-uns than the round muzzled gun.
However, I can see very little advantage to a folding butt, except possibly that of packing the gun away in a smaller space in times of peace?????
The gun was made around 1750 by P. Lorandi, probably in the Tosco Emilian area of Italy. A pair of pistols by this maker are preserved in the Stibbert Museum in Florence.
Any suggestions as to the advantages of this design would be welcome, although if Rog and Crowbard would restrain themselves to within the bounds of possibility that might be a help- although - no, go to it chaps - I withdraw that last proviso. ALL suggestions fairly gratefully received.
Posted by Mike and Ann at 16:49 5 comments:
Saturday, 27 June 2015
Saturday (2).
Let's try again. This started on Thursday when Ann answered our 'phone and a Germanic sounding voice said , "Ann, Zis is Benjamin, und my grandfarser has asked me to England to telephone, and tell you he there is, and may he come and you and Mike to visit?" I don't think I can keep up this German accent, it too much like is to 'Allo 'Allo........ and not only that but it's catching, so I think I'd better to my standard English revert. I must also go back forty years to the mid seventies when the male voice choir with which I sung basso profundo was asked to go and stay with the Detmold Police Choir in Germany, and with the assistance of the 'Blues and Royals' military band (who were then stationed in Detmold) give a series of concerts (I seem to remember that at the time this was to help, support, and generally encourage our entry into the Common Market). Ann and I were billetted with Friedhelm, the above photographed gentleman, and his late wife Karen. He too sung basso profundo, but with a wider range than I ever had. To cut things short we took to each other, became firm friends, and have remained in contact ever since. As far as I'm concerned it was about the only good thing, so far, to have come out of the Common Market idea.
The above photo is of his present partner, Erika, His wife Karin having died some years ago.
Above is Ann in her usual corner.
The two of them turned up about one o'clock today, and we partook of a salad and cold meats lunch (but with hot boiled new potatoes, which always seems to me to turn a cold-meats lunch into a hot lunch) followed by fruit and then cheese.
We hadn't seen Friedhelm for two or three years, so catching up using his eleven words of English, and my seven German words, took a long time, but was thoroughly enjoyable. Ann took the above photo just before they left at about four thirty. Isn't it odd that with some friends, even after a long gap, the threads can be picked up immediately in a very relaxed manner?
By the way (if any of my family are reading this) as he was leaving Friedhelm asked me to give his very warm regards to all of you, naming you all by name, and in order of seniority. He really is a good chap.
Posted by Mike and Ann at 20:37 5 comments:
This blog entry is really for the information of our friends Sue and David. In that the above pictured hydrangea shrub was given to us (by Sue and David) on our fiftieth wedding anniversary two years ago. It's come through the last two winters looking fit and healthy and is now about to bloom again. Thank you Sue and David.
Another view of our garden looking summery.
Meant to do a rather longer blog entry, but the machine is playing up a bit (it seems to be reluctant to take more than about four photos for any one entry) so will come back a bit later and try it with the second half of today's entry.
Posted by Mike and Ann at 18:16 1 comment:
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Short Cuts
Born in Northumberland in 634, St. Wilfrid was educated at Lindesfarne and then spent some time in Lyons and Rome. Returning to England, he was elected abbot of Ripon in 658 and introduced the Roman rules and practices in opposition to the celtic ways of northern England. In 664, he was the architect of the definitive victory of the Roman party at the Conference of Whitby. He was appointed Bishop of York and after some difficulty finally took possession of his See in 669. He labored zealously and founded many monasteries of the Benedictine Order, but he was obliged to appeal to Rome in order to prevent the subdivision of his diocese by St. Theodore, Archbishop of Canterbury. While waiting for the case to be decided, he was forced to go into exile, and worked hard and long to evangelize the heathen south Saxons until his recall in 686. In 691, he had to retire again to the Midlands until Rome once again vindicated him. In 703, he resigned his post and retired to his monastery at Ripon where he spent his remaining time in prayer and penitential practices, until his death in 709. St. Wilfrid was an outstanding personage of his day, extremely capable and possessed of unbounded courage, remaining firm in his convictions despite running afoul of civil and ecclesiastical authorities. He helped bring the discipline of the English Church into line with that of Rome. He was also a dedicated pastor and a zealous and skilled missionary; his brief time spent in Friesland in 678-679 was the starting point for the great English mission to the Germanic peoples of continental Europe. His feast day is October 12th.
Brigid was probably born at Faughart near Dundalk, Louth, Ireland. Her parents were baptized by St. Patrick, with whom she developed a close friendship. According to legend, her father was ... continue reading
For James there was no indication that this was the day that his life would change. The dawn for him was not the bright beginning of a new day, but the end of long fruitless night of ... continue reading | shop
St. John, Apostle and Evangelist (Feast day - December 27th) St. John, the son of Zebedee, and the brother of St. James the Great, was called to be an Apostle by our Lord in the first ... continue reading
Innocent was born at Albano, Italy. He became Pope, succeeding Pope St. Anastasius I, on December 22, 401. During Innocent's pontificate, he emphasized papal supremacy, commending the bishops of ... continue readingMore Saint of the Day
Our Lady of Guadalupe December 12 (USA) When we reflect on the feast of Our Lady of Guadalupe we learn two important lessons, one of faith and one of understanding. Missionaries who first came to Mexico with the conquistadors had little success in the beginning. After ... continue readingMore Female Saints
St. Michael the Archangel - Feast day - September 29th The name Michael signifies "Who is like to God?" and was the warcry of the good angels in the battle fought in heaven against satan and his followers. Holy Scripture describes St. Michael as "one of the chief ... continue reading
The name Gabriel means "man of God," or "God has shown himself mighty." It appears first in the prophesies of Daniel in the Old Testament. The angel announced to Daniel the prophecy of the seventy weeks. His name also occurs in the apocryphal book of Henoch. He was the ... continue reading
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Ava was the daughter of King Pepin. She was cured of blindness by St. Rainfredis, became a Benedictine nun at Dinart, Hainault, and later was elected Abbess. Her feast day is April 29th. continue reading
By Deacon Keith A Fournier
On July 15th in the Liturgical Calendar of the Latin Rite of the Catholic Church, we commemorate the life, holiness, work and death of a great Bishop and Doctor named Bonaventure. He was born in 1218, became a Franciscan Friar in 1243, and died in 1274. A friend ... continue readingMore Christian Saints & Heroes


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Friday, 06 Apr 2012 07:18 AM
Romney has a rich trove of potential candidates from whom to pick, from Congressman Paul Ryan of Wisconsin to Senator Rob Portman of Ohio.
Others on the list are Senator Marco Rubio of Florida, Governor Bobby Jindal of Louisiana, Governor Susana Martinez of New Mexico, Governor Chris Christie of New Jersey, Governor Bob McDonnell of Virginia, and Nevada Governor Brian Sandoval.
Editor's Note: Do You Like Romney? Vote in This Urgent Poll
Who best helps his chances against Democratic President Barack Obama in the Nov. 6 election? Does he pick someone who can help him win a state, or a Latino to reach out to Hispanics? A woman?
Romney advisers are adamant about the most significant requirement of the job, that the person selected have the ability to immediately step into the presidency if needed.
"I honestly believe he wants someone who can be president. Governing comes first and the politics comes second," said a senior Romney adviser.
Charlie Black, an informal Romney adviser and veteran Republican strategist, said that beyond being able to serve, a second requirement is needed. "Politically you want to have someone who does no harm," he said.
In 2008, Republican hopeful John McCain made a splash by choosing relative unknown Sarah Palin as his vice presidential nominee. But the former Alaska governor ended up being seen as a liability, committing gaffes and failing to grasp policy issues.
President George H. W. Bush's choice of Indiana Senator Dan Quayle was ridiculed after the pair took office and his vice president earned notoriety for gaffes and errors.
The name most associated with Romney in the last week is Ryan who looked to have a personal chemistry with the former Massachusetts governor when they campaigned in Wisconsin.
The two men appeared jointly before crowds, casually let each other answer voters' questions and stood side by side as they handed out sandwiches at a fast food restaurant. Romney aides noted the two men developed a good rapport.
Ryan is the 42-year-old chairman of the House of Representatives Budget Committee and author of a budget plan loved by conservatives and hated by Democrats.
His presence on the ticket could help Republican chances of winning Wisconsin for the first time since 1984, and he could rally conservatives who are unenthusiastic about the former Massachusetts governor.
But Ryan's presence could also draw more scrutiny of his plan for budget cuts.
Rubio offers a solid conservative message plus, as a Cuban-American, he could help swing Hispanic voters in the traditional battleground state of Florida.
Portman would bring deep budget expertise to the table as a former White House budget director under President George W. Bush. He could help Romney win Ohio, which Obama won in 2008 on his way to victory over Republican Senator John McCain.
Martinez could help with Hispanics and women voters who thus far have been unexcited about Romney. And the bludgeoning style of Christie would help energize Republican voters.
Republican strategists say ramping up conservative enthusiasm for turning out to vote with the more moderate Romney at the head of the ticket is a key winning the uphill fight against Obama.
"Ultimately Romney will need to attract independents to win. But he has to start by consolidating conservatives and the best and easiest way to do that is with a VP pick that shores up the base and creates some enthusiasm," said Republican strategist Mark McKinnon.
Word is that Romney has yet to begin his search in earnest, a point he stressed on Thursday in an interview with Fox News Radio's "Kilmeade and Friends."
"I've got no predictions on who No. 2 will be," said Romney. "I've still got to make sure that I'm No. 1."
Republican experts caution against using the selection to satisfy one part or another of the Republican Party.
"The most important thing is to pick somebody who can be president," said Republican strategist Mike DuHaime, who has advised Christie in the past. "In many ways this is the most presidential decision that a candidate makes."
Some potential running mates have publicly declared they do not want the job, like Rubio, and others have been cool to the idea, such as Christie.
"I'm not going to be the vice president," Rubio said in Florida this week.
Also ruling out the idea were Martinez and South Carolina Governor Nikki Haley, although vice presidential candidates have a habit of denying they are interested in the job, right up until they accept it.
Some potential vice presidential running mates this year might want to hold their fire until they can run for the Republican presidential nomination in 2016 should Romney fail to defeat Obama.
"There are plenty of Republicans who would make a great vice presidential candidate, however, some may feel better prepared running in the next election and rather than being put upon a pedestal prematurely," said Republican strategist Ron Bonjean.
© 2015 Thomson/Reuters. All rights reserved.
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Kepler-452b revolves around a sun much like our own.
Accused Scientist Reaches Plea Deal
July 12, 2013|
A Chinese researcher working in Wisconsin who was accused of stealing an experimental cancer drug pleads guilty to a lesser charge.
July 12, 2013|
A Chinese researcher working in Wisconsin who was accused of stealing an experimental cancer drug pleads guilty to a lesser charge.
July 1, 2013|
Ecologist Nalini Nadkarni advances forest conservation and science advocacy by enlisting the help of prisoners.
July 1, 2013|
A forest ecologist comes down from the canopy to bring science to the masses, forming a series of improbable collaborations with prisoners.
July 1, 2013|
Ocean viruses can impact marine ecosystems in several ways.
July 1, 2013|
Viruses abound in the world's oceans, yet researchers are only beginning to understand how they affect life and chemistry from the water's surface to the sea floor.
June 1, 2013|
Regular supplies of food for scavenger birds in Spain may not be the most effective conservation strategy, as smaller birds are bullied away.
June 1, 2013|
Assistant Professor, Department of Zoology, University of British Columbia. Age: 34
June 1, 2013|
Yale University evolutionary biologist Steven Brady studies the evolutionary impacts of roads on the amphibians.
May 23, 2013|
Researchers discover a microbe living at -15°C, the coldest temperature ever reported for bacterial growth, giving hope to the search for life elsewhere in the cosmos.
May 20, 2013|
Experimental cancer therapeutics delivered to tumors via nanoparticles could provide a safer and more effective therapy than conventional chemotherapy.


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