text:
Suspended NASCAR driver Allmendinger says he tested positive for ADHD drug
There are 8 comments on the The Globe and Mail story from Aug 7, 2012, titled Suspended NASCAR driver Allmendinger says he tested positive for ADHD drug. In it, The Globe and Mail reports that:
Suspended NASCAR driver AJ Allmendinger tells ESPN he tested positive for a prescription drug usually used to treat attention deficit disorder.
Join the discussion below, or Read more at The Globe and Mail.
#1 Aug 7, 2012
All i can say AJ is you're a dumba$$.
I'm not involved in NASCAR in any way but I know everyone that is can be tested at any time and the last thing I would do is take something another person gives to me.
#2 Aug 7, 2012
I agree....DumbAss'ishness !
Tired?! Perhaps it's best then if you stay out of cars going 165+mph.
Add the fact that you down unknown pills from "friends"...well NASCAR is best without you.
United States
#3 Aug 8, 2012
are you kiddn me racin or pills. come on man really
Since: Dec 06
Location hidden
#4 Aug 10, 2012
Page right out of Jeremy Mayfield's playbook. He didnt happen to mix it with some claritin d as well did he? C'mon man. I thought any perscription meds needed to be cleared with Nascar doctors ect ect ect. Coveted ride with a top team and this guy is poppin pills.......
#5 Aug 10, 2012
Just what NASCAR needs is some dope with ADD driving around; reminds us of when old dale used to fall asleep at the wheel.
#6 Aug 10, 2012
His wife is hot. She's got a great can.
#8 Aug 11, 2012
Hell yeah and she's probably available while AJ is on the road to recovery hehehe! She may be hangin' out with Jeremey Mayfield..??
#10 Aug 13, 2012
Hell yes!!!
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Allergies, obesity, other risk factors and survival from pancreatic cancer†
Article first published online: 8 FEB 2010
DOI: 10.1002/ijc.25240
Copyright © 2010 UICC
International Journal of Cancer
Volume 127, Issue 10, pages 2412–2419, 15 November 2010
Additional Information
How to Cite
Olson, S. H., Chou, J. F., Ludwig, E., O'Reilly, E., Allen, P. J., Jarnagin, W. R., Bayuga, S., Simon, J., Gonen, M., Reisacher, W. R. and Kurtz, R. C. (2010), Allergies, obesity, other risk factors and survival from pancreatic cancer. Int. J. Cancer, 127: 2412–2419. doi: 10.1002/ijc.25240
- †
Novelty and impact: Few studies have investigated whether established risk factors for pancreatic cancer are related to survival. We report on results from a study of 475 patients at our institution who took part in an epidemiologic study and were followed for outcome. Self-reported allergies, known to be associated with reduced risk of pancreatic cancer, were found to be associated with improved survival: the adjusted hazard ratio was 30% lower than for those without allergies. This is a novel finding that is of great interest because it suggests that this aspect of the immune system can potentially be harnessed to improve outcomes for these patients.
Publication History
- Issue published online: 8 FEB 2010
- Article first published online: 8 FEB 2010
- Manuscript Accepted: 21 JAN 2010
- Manuscript Received: 16 OCT 2009
- Abstract
- Article
- References
- Cited By
- pancreatic cancer;
- survival;
- allergies;
Survival from pancreatic adenocarcinoma remains extremely poor, approximately 5% at 5 years. Risk factors include smoking, high body mass index (BMI), family history of pancreatic cancer, and long-standing diabetes; in contrast, allergies are associated with reduced risk. Little is known about associations between these factors and survival. We analyzed overall survival in relation to risk factors for 475 incident cases who took part in a hospital based case–control study. Analyses were conducted separately for those who did (160) and did not (315) undergo tumor resection. Kaplan-Meier methods were used to describe survival according to smoking, BMI, family history, diabetes, and presence of allergies. Cox proportional hazards models were used to adjust for covariates. There was no association with survival based on smoking, family history, or history of diabetes in either group. Among patients with resection, those with allergies showed nonstatistically significant longer survival, a median of 33.1 months (95% CI: 19.0–52.5) vs. 21.8 months (95% CI: 18.0–33.1), p = 0.25. The adjusted hazard ratio (HR) was 0.72 (95% CI: 0.43–1.23), p = 0.23. Among patients without resection, those with self-reported allergies survived significantly longer than those without allergies: 13.3 months (95% CI: 10.6–16.9) compared to 10.4 months (95% CI: 8.8–11.0), p = 0.04, with an adjusted HR of 0.68 (95% CI: 0.49–0.95), p = 0.02. Obesity was nonsignificantly associated with poorer survival, particularly in the resected group (HR = 1.62, 95% CI: 0.76–3.44). The mechanisms underlying the association between history of allergies and improved survival are unknown. These novel results need to be confirmed in other studies.
Pancreatic adenocarcinoma is the fifth leading cause of cancer mortality. The estimated number of new cases in the US in 2009 is 42,470 and the estimated number of deaths is nearly as high, 35,240.1 The high mortality is due to the advanced disease stage at the time of diagnosis and the limited effectiveness of systemic therapies. Only a small percentage of patients, about 15–20%, have a resectable tumor.2 Five-year survival is approximately 5.5%,3 although recent years have seen a small improvement in 2-year survival from 6.1% in 1973 to 10.2% in 2002. This is thought to be attributable to increased use of resection, improved surgical techniques leading to lower perioperative mortality, and increased use of adjuvant chemotherapy.2, 4 Although resection is the most effective therapy for pancreatic cancer, recurrence and death from disease occur in the vast majority of patients.
Little is known about the relationship between established risk factors for pancreatic cancer and survival. Smoking is associated with about 2- to 3-fold increased risk.5–8 Obesity is also a risk factor, considered "convincing" by the recent World Cancer Research Fund report, based on data from 28 studies.9 Long-standing diabetes5–8, 10 and high plasma glucose concentration without overt diabetes11 have been reported to be positively associated with disease; in addition, new onset diabetes may be an early marker of pancreatic cancer.12–14 Family history increases risk,15 accounts for 4–16% of cases,16 and interacts with smoking.17–19 In contrast, studies have consistently shown reduced risk for pancreatic cancer among individuals with allergies, particularly respiratory allergies.20–23 The mechanisms through which this protective effect works remain unknown.
The purpose of this study was to evaluate the association of established risk factors for pancreatic cancer with outcome. In cases recruited to a case–control study of pancreatic cancer at a large referral center, we investigated the association of smoking history, obesity, diabetes, family history of pancreatic cancer, and allergies on survival, controlling for clinical factors known to influence outcome.
Material and Methods
Study population and data collection
Cases in this analysis came from an ongoing hospital-based case–control study and Familial Pancreatic Cancer Registry at Memorial Sloan-Kettering Cancer Center (MSKCC). Patients were eligible if they were over age 21 years, spoke English, and had pathologically or cytologically confirmed adenocarcinoma of the pancreas. Patients were recruited from the surgical, medical oncology, and gastroenterology clinics at MSKCC when seen for initial diagnosis or follow-up, including postsurgical care or chemotherapy. The 475 patients in this analysis were recruited between April 1, 2004, and May 1, 2008 and consented to the study within 6 months of diagnosis. Among those cases approached and eligible, 77% have enrolled. The study was approved by the MSKCC Institutional Review Board and all enrolled participants signed informed consent.
The study questionnaire was administered by the research study assistant by telephone or in person and covered known and potential risk factors for pancreatic cancer. Detailed smoking history was collected, as well as information about height and weight at different times and history of diabetes. The question on allergies asked the respondent if he or she "ever had allergies to foods, animals, pollen or hay fever, plants such as poison ivy, bee stings, molds, medicine or vaccines." The interviewer recorded a "yes" or "no" response to this question and those who said "yes" were asked "What are you or have you been allergic to? Anything else?" The question was open ended and there was no restriction on the number or type of allergies patients could name. There was not a specific question on asthma. Detailed family history of cancer was collected in a separate questionnaire.
Statistical analyses
The outcome was overall survival. Because outcome and the clinical factors associated with outcome varied substantially according to whether patients had resection, analyses were conducted separately for patients who underwent resection (n = 160) and those who did not (n = 315). For the resected patients, the baseline from which overall survival was calculated was the date of surgery; for the nonresected patients, the baseline was the date of diagnosis. Patients were followed to date of death or last follow up. The chi-square test was used to examine differences in characteristics between the resected and nonresected cohorts. Chemotherapy treatment was initiated at different times from the baseline; therefore, a landmarked analysis was used in which the start date for calculation of survival was 2 months from the baseline. Eighteen patients from the resected cohort and 37 patients from the nonresected cohort died or were lost to follow-up in that time period and were excluded from analyses of the chemotherapy variable. Patients who did not start chemotherapy within 2 months of the baseline dates were considered not to have had chemotherapy.
Survival probabilities were estimated using Kaplan-Meier methods and strata were compared using the log-rank test. Univariate analyses were conducted to evaluate the association of clinical variables and risk factors with overall survival. Clinical variables included: Eastern Cooperative Oncology Group performance status (>1 vs. ≤1), with higher score representing poorer performance; nodal status (N1 vs. N0) and tumor stage (T3/T4 vs. T1/T2) in the resected patients; metastatic disease in the nonresected patients [metastasis (M1) vs. no metastasis (M0)]; and chemotherapy at 2 months after baseline (yes/no). Risk factors included age, gender, smoking history (never, past, current, with current smokers including those who smoked within the year before diagnosis), body mass index [BMI, weight (kg)/height (m2) based on usual adult weight, classified as normal (<25), overweight (25 to <30), and obese (≥30)], diabetes diagnosed ≥3 years before the pancreatic cancer diagnosis (yes/no), family history of pancreatic cancer (any first-degree relative vs. none), history of any allergies (yes/no) and history of hay fever, seasonal allergies, or allergies to grass or pollen (yes/no; i.e., any mention of these or similar allergies), and history of allergy to medications (yes/no; i.e., mention of allergy to any medication). Presence of any allergies, BMI, and those variables that were significant in the univariate analyses were included in Cox regression models to adjust for covariates. In separate models, allergies to medications or hay fever were included with the same covariates, excluding the presence of any allergies. SAS 9.2 was used for all analyses.
As shown in Table 1, the mean age of patients in this study was 64 and 52% were male. They were primarily Caucasian (88%) and Catholic (45%). Fifty-three percent had ever smoked cigarettes and 12% were current smokers. Forty-three percent were overweight and 23% were obese; 10% had diabetes diagnosed at least 3 years before the pancreatic cancer diagnosis. Ten percent reported a first-degree relative with pancreatic cancer, with resected patients more likely than nonresected patients to report this family history (15% vs. 8%, p = 0.02). Allergies were reported by 52%. Most patients had high-performance status (≤1). Among the resected cohort, two-thirds had positive lymph nodes and 91% had tumors classified as T3/T4. Among the nonresected cohort, 56% had metastatic disease. Seventy-seven percent received chemotherapy 2 months after baseline, including 63% of the resected and 85% of the nonresected patients.
Figure 1 shows survival in the resected cohort according to the presence or absence of allergies: median survival for those with allergies was 33.1 months (95% CI: 19.0–52.5) compared to 21.8 months (95% CI: 18.0–33.1) for those without allergies (p = 0.25). In univariate analyses for the resected cohort (Table 2), there was no statistically significant association with survival based on any of the risk factor variables studied. The hazard ratio (HR) for allergies showed reduced risk (HR = 0.74, 95% CI: 0.45–1.23); there was also reduced risk associated with allergies to medications (HR = 0.62, 95% CI: 0.32–1.23), while hay fever was not related to risk. Increased risk was found for those who were obese (HR = 1.56, 95% CI: 0.75–3.23). The only factors significantly related to survival were the presence of positive lymph nodes (HR = 2.36, 95% CI: 1.31–4.25) and tumor stage (HR = 4.39, 95% CI: 1.07–18.0). When the presence of any allergy, BMI, nodal status, and tumor stage were included in the same model, there was little change in the HRs for allergies or BMI. Nodal status and tumor stage remained associated with overall survival although stage was not statistically significant. In separate multivariate analyses for allergies to medications and hay fever, results were similar to those reported above: for allergies to medications, HR = 0.66 (95% CI: 0.33–1.31); for hay fever, HR = 1.20 (95% CI: 0.65–2.22) (data not shown in tables).
For the nonresected cohort, median survival for those with allergies was 13.3 months (95% CI: 10.6–16.9), compared to 10.4 months (95% CI: 8.8–11.0) for those without allergies, p = 0.04 (Fig. 2). In univariate analysis (Table 3), a lower HR was observed for those with any allergies (HR = 0.75, 95% CI: 0.57–0.99) with little influence apparent for either allergies to medications (HR = 0.81, 95% CI: 0.58–1.13) or hay fever (HR = 0.84, 95% CI: 0.60–1.18). Obesity (HR = 1.17, 95% CI: 0.82–1.68) and other risk factors did not influence survival. Poor performance status and the presence of metastases were associated with poorer survival: HR = 2.93 (95% CI: 1.73–4.96) and HR 2.11 (95% CI: 1.49–3.00), respectively. Having chemotherapy was associated with longer survival (HR = 0.66, 95% CI: 0.47–0.94). In multivariate Cox regression models, results for both allergies and obesity were slightly strengthened. The HR for allergies was 0.68 (95% CI: 0.49–0.95), while that for obesity was 1.38 (95% CI: 0.90–2.11). In separate analyses for allergies to medications and hay fever, the adjusted HR for those allergic to medications was 0.68 (95% CI: 0.45–1.04), while for hay fever HR = 0.88 (95% CI: 0.59–1.31) (data not shown in tables).
Among patients with pancreatic cancer who did not undergo resection, we found significantly improved survival for those who reported a history of allergies compared to those without allergies. Among those who underwent resection, survival was more favorable for those with allergies, although this difference was not statistically significant. As the HR associated with allergies was similar for the two groups, it is likely that the lack of statistical significance for the resected group was related to the smaller sample size. Post-hoc power calculations indicate that power to detect the differences observed was <30% in the resected patients. To our knowledge, our study is the first analysis of survival of pancreatic cancer in relation to allergies. Pompei et al.24 found higher probability of cure and lower disease progression and longer survival in 92 patients with various types of cancer who had allergies compared to 182 without allergies; none of the 16 pancreatic cancer patients in that study had allergies, so comparisons could not be made in these patients.
The association of allergies with reduced risk of developing pancreatic cancer is well established. A recent review and meta-analysis of 14 studies21 conducted from the 1970s to the 1990s showed an overall odds ratio (OR) of 0.82 (95% CI: 0.68–0.99) for the presence of any allergies, and a stronger effect (OR = 0.75, 95% CI: 0.65–0.87) in the studies that adjusted for smoking. Reduced risk is most consistently associated with respiratory allergies, such hay fever and allergies to grass, pollen and plants.20, 22, 25–30 Studies examining risk of pancreatic cancer in relation to medications have shown inconsistent results,22, 29, 31, 32 probably reflecting different patterns of medication usage in different times and locations. The present analysis indicated that allergies to medications appear to be associated with survival, while hay fever was not. Among our patients with allergies to medications, about two-thirds were allergic to antibiotics and about one-quarter allergic to pain medications (data not shown). Larger studies are needed to examine this further. The number of patients with other specific allergies was too small for meaningful analysis.
Although our results for the association between obesity and survival in patients with pancreatic cancer did not reach statistical significance, they are consistent with other studies. A recently reported hospital based epidemiologic study has shown that high BMI, and particularly obesity, in adulthood and the year before diagnosis is associated with poorer survival.33 A second study in a similar setting found poorer survival for patients with usual adult BMI ≥ 35.34 Increased risk of death in resected patients with BMI > 35 at the time of referral was also noted in a record-based study.35 The observed HRs in our study, particularly in the resected cohort, are fairly similar to those found in other studies and point to a potential increase in risk of mortality among heavier patients. As noted above, reduced power in the resected cohort affects our ability to reach statistical significance. Our results are also consistent in finding stronger associations between BMI and survival among those with resection. In an earlier study at our institution, we noted increased complications among resected patients with generalized obesity and visceral fat.36 Further examination of the association of obesity with outcomes in patients with pancreatic cancer is warranted. Other studies in a population similar to ours have found, as we have, no difference in survival according to age, race, sex or smoking.37
The mechanisms underlying a possible protective effect of allergies in cancer patients are unclear. Immune defense against tumors involves a number of different cell types, including CD8+ T cells (cytotoxic T lymphocytes) and CD4+ T cells (helper cells) from the adaptive immune system. In pancreatic cancer, presence of both these cells types among tumor-infiltrating lymphocytes appears to be important for survival.38 The presence of allergies is associated with 1 subset of CD4+T cells: when sensitive individuals are exposed to environmental allergens, CD4+T cells differentiate into T helper type 2 (Th2) effector cells, rather than T helper type 1 (Th1) cells, the dominant type in nonatopic individuals. These two subgroups release different groups of cytokines: Th1 cells produce primarily IFN-γ, while Th2 cells produce primarily IL-4. In the presence of IL-4, B cells switch to production of IgE antibodies rather than IgG or IgA antibodies. IgE itself is a potential factor in cytotoxicity towards tumors. In a small in vitro study,39 Fu et al. found that whole serum from patients with pancreatic cancer resulted in antibody-dependent cell-mediated cytotoxicity which was reduced when IgE was depleted. These findings are consistent with studies in a mouse model of ovarian cancer.40, 41 In glioma, another tumor for which self-reported allergies are consistently associated with reduced risk,42–45 total serum IgE was strongly related to survival.46 This aspect of immunity is addressed by the emerging field of allergo-oncology.47
Another potentially important factor in host immune defense against tumors is the production of T regulatory cells (Tregs) by tumors. Tregs secrete immunosuppressive cytokines and suppress cytotoxic T lymphocytes, thereby protecting tumors from attack. It has been observed that immunosuppressive Tregs are elevated in peripheral blood cells of patients with pancreatic cancer48, 49 and that depletion of Tregs in a mouse model of pancreatic cancer led to stronger immune response.50 In a genetic mouse model with a mutation in codon 12 of kras, mimicking the majority of human pancreatic tumors, the immune response is dominated by immunosuppressive cells, including Tregs, that are likely to suppress tumor infiltrating effector T cells.51 This was observed at both preinvasive and later stages of tumor growth. In addition, there is a strong desmoplastic response in pancreatic cancer, resulting in cytotoxic T cells' being trapped in the stroma and isolated from the tumor.52, 53 We can speculate that these failures of the usual immune response to pancreatic tumors may allow for a role for other immune mechanisms, such as those represented by the IgE/Th2 pathway.
Strengths of our study include the availability of extensive epidemiologic and clinical data on our patients. Prevalence of allergies was high in our population, with about half the patients reporting some allergy, and it is possible that some reported allergies have other types of causes. Published reports from case–control studies of allergy and risk show a wide range in prevalence of allergies,20–22 attributable to several factors. There has been a well-documented increase in prevalence of allergies in western countries.54–59 The studies covered different populations (Europe, Asia, various regions in North America), so that both environmental exposures and genetic background of the population are likely to be different. In addition, the specific questions asked about allergies differed among studies.
Our patient population is not typical, since a larger proportion (34%) were resected than among most patients with pancreatic cancer and overall survival is longer than expected, even in the nonresected patients. This reflects selection of a specialized tertiary-case institution such as ours by patients with treatable disease and the bias towards longer term survivors in all case–control studies of pancreatic cancer. These factors are similar in other epidemiologic studies of survival in relation to patient characteristics.33, 35, 37 Among eligible patients who were approached for this study, those who were aged >70 years were more likely to refuse to participate, particularly among the women (data not shown). We did not ascertain cause of death, so it is possible that for some patients who died, there was a cause other than pancreatic cancer. Further, it is possible that there were differences between in-person and telephone interviews in the health of the respondents and likelihood of recalling allergies, which could have led to biased results; since we did not record the interview method, we were unable to evaluate this possibility.
In conclusion, the very poor outcome for pancreatic cancer and the possibility of new therapeutic avenues raised by the findings on allergies suggest that this is a promising area for future research. Such research should be directed towards further prospective studies to evaluate associations of allergies with survival to replicate these results, and mechanistic studies to help explain the biologic basis of these observations. Our results for the association of obesity with survival support those of other investigators, and indicate the importance of continuing work in this area as well to understand the mechanisms involved.
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We love to share our house with someone who wants to have a memorabile vacantion on OBX without paying higher prices. Twenty minutes ride to the beach. Also enjoying the cool acomodations with a gym, and game room included. :) Details please contact. Learn More
Have a pool table and a private gym top floor. Shared spaces are Kitchen, living room area, game room, laundry room, porch. Private access to the bathroom and room. We are leaving in the house, but have a busy schedule in the summer most of the time out. Peaceful space just minutes away from the beach! Quiet family friendly neighborhood. Car is the best getting around. We are a family, any very late parties are not recommended. We respect any request or preference from our guests. Yo...
Fall asleep and wake up listening to the sea!Golf court only 3km One bedroom apartment,living room and a balcony with BBQ where you can make great meals.The beach is very beautiful and is 100m down the street!You will be charmed by the Praia da Luz Learn More
One bedroom apartment with double bed , wall closet and a fantastic balcony with a fabulous view facing east , table, chairs and a grill allows fine dining outdoors; a bathroom , kitchen and a common room with a small balcony facing west Whole house was renovated in Jan 2015 I'm always happy to help. My guests are encouraged to contact me whenever they want . Apartment very close to the beach ... 100m! is just down the street and there is a beautiful beach with a single rock, black volcan...
Praia da Luz
We are a homestead called Sundog, search Sundog Permastead for info. We border a 28,000 acre forest called Lubrecht to hike in. Missoula is 30 mi W, Glacier National Park is 2 hrs N, and Blackfoot River (A River Runs Though It) is 10 mi away. Learn More
- Have you ever wondered what spending the night in a Yurt might be like, or sleeping in a forest cottage? I assure you these dwellings are unique and the surroundings are spectacular. - The use of cigarettes(ecig), alchol or drugs is not permitted. - Book and DVD library and unlimited walking and hiking trails. - Yurt with no walls for lounging. - Trampoline - Shower We're usually busy tending to the land, but someone will be available to help or answer questions or concerns. Very priv...
Carrick Farm is a small farm on the edge of Loch Goil. Self-catering Holiday Home sleeping up to 6 people. Well behaved pets welcome. Stables for hire. Loch & mountain views. Walk hike, swim, sail & relax We also have 2 double B&B Rooms Learn More
The Holiday Home has a double bedroom with an en-suite WC. The Second Bedroom has 2 single beds. The living area converts into a double bed. Shower room with WC. Kitchen with Cooker, Microwave, Kettle, Toaster Hairdryer, iPod Doc (Classic), games, DVD player Garden Seating Available Stables & grazing available by separate Negotiation. There is plenty of parking. If you are looking for us when you arrive, you will most likely find us in wellies and a smile on our faces (well hopefully smi...
Carrick Castle, Lochgoilhead
Alder Brook Cabin is a small rustic lodge on the edge of the woods. It features a single room with attached screened porch, bunks for two, electric lights, a small fridge, coffee maker, microwave and WIFI. Enclosed outdoor hot and cold shower and marine style toilet are located twenty five feet away. The porch is a perfect spot to enjoy your morning coffee, a glass of wine or tumbler of scotch in the evening. Board games are available. There is a fire pit with benches outside for cozy ev...
House includes a large living room with kitchen, open tothe living Two Bedrooms, the first with a double bed and the second with two single beds. Terace with garden and inflatable spa Attached garage Learn More
Possibility to loaning a baby bed and a gas placha The house is located 5 kilometers from the Amance lake, 30 kilometers from the lake forest of Orient and the lake of Der. Locates 15 kilometers from Nigloland. Vineyard nearby Troyes and the stories 40 kilometers
Appartamento nuovo, moderno, 6km dal mare. Camera con letto matrimoniale, bagno con doccia in condivisione con l'host. Aria condizionata, TV, Wi-Fi, lavatrice. New apartment, modern, 6km from beaches. Room with double bed, bathroom with shower shared with the host. Air conditioning, TV, Wi-Fi, washing machine. Al Primo ed ultimo piano di un complesso moderno e ben rifinito. Composto da due camere da letto, un bagno, soggiorno con cucina a vista con penisola, ripostiglio, soppalco in legno, ...
Comfortable studio flat close to town and river. Large double bed or 2 singles, furnished kitchen with all mod cons, Bathroom with shower, tv and wifi. Ideal for exploring area, Borders or Edinburgh. On street parking, bicycle storage available. Learn More
In an idyllic setting overlooking river Tweed and within easy walking distance of local facilities, and bus connections. Guests have access to use of all flat amenities, washing line and tumble drier if required Owner available nearby for any help if needed In a quiet area, well cared for. Good for enjoying the peace and tranquillity of the countryside around or for excellent shopping and dining outlets. Central bus stop on high street, 5 mins walk away. Regular bus services to Edinbur...
Het is een mooi karakteristiek dorpje aan een rivier(La Vie), met een kasteel , een strandje in de rivier, en het ligt 18 km van het mooie plaatsje St.Gilles -Croix la Vie aan de Atlantische Oceaan. In de omgeving veel historische plekken . U heeft ook toegang tot een zonnige tuin .
Our accommodation is located on a farm called Mjóanes. It is between Egilsstaðir and Hallormsstaður - 17 km from Egilsstaðir and 6 km from Hallormsstaður the biggest forest in Iceland. There is quiet, peaceful and beautiful landscape to walk in. Learn More
Peaceful in the countryside 2 is one of my four rooms in the accommodation, the other rooms have the same name on my listings but 1, 3 and 4. If this room is booked at the day you want to arrive please check the other rooms or contact me. There is one bathroom to share and it is new with very nice shower. The guests have access to kitchen with everything that is needed to make breakfast, lunch or dinner. I do not serve breakfast but if someone prefer to have some I offer bread, butter, c...
This is a twin bedded room with a view of the rear garden. We include breakfast, a two course evening meal and for guests staying more than one week one load of laundry. We have been welcoming guests from all nationalities for more than 5 years. Learn More
Lillefjord kan by på mange flotte naturopplevelser. Fiskemulighetene er store, det er mange fine fiskevann hvor røye og ørret er den mest utbredte fiskesorten. Kokelv sjøhus med utleiebåter er 10 min unna. 2 timer med bil til Nordkapp. Helt inne i fjorden strekker landskapet seg innover et elveleie og ender opp i en flott bergformasjon som egentlig minner om Lofotfjellene. Nede ved veien er det etablert en arkitekttegnet rasteplass som del av konseptet Nasjonal Turistveg. Midt på sommeren sk...
Double room-saloon with private balcony in the beach in Gavá Playa. The best location you can imagine. Beach - few steps away, bus station - 3 mins walk (30 mins to Barcelona PL. España center) Apartment is located in third line to the beach. Learn More
The room is a loft (11 m2) it can be dining room and bed room is equipped with everything you may need during your stay, including a private terrace where my guests can relax and enjoy the beautiful view with the pine tres and the bird singing. The terrace is equipped with a table, and twoo chairs. The privacy during the stay is almost complete, the common places are the kitchen and the bathroom. - double sofa-bed - table and chairs. - a place to keep clothes and suitcase - lamp - Inte...
"APARTAMENT A" Jasny apartament dla 2 osób, znajduje się na 1 piętrze w odnowionej kamienicy. Nowoczesny wystrój, komfortowe duże łóżko, aneks kuchenny i łazienka Obok apartamentu A, znajduje się apartament B dla 4 osób, który również możesz wynająć. Drodzy goście, Mieszkanie wyposażone jest w jedno dwuosobowe łóżko, stół z trzema krzesłami, przestronna szafa. Aneks kuchenny z pełnym wyposażeniem oraz łazienka. W mieszkaniu jest dostępna sieć Wi-fi. Jeśli będziecie czegokolwiek potrzebowal...
The flat is located by route E16 between Oslo and Bergen, 970 m above sea level. There is a wide range of possibilites for sports and activites both in summer, autumn and winter. Prices depend on high/low season and the number of days staying. Learn More
Filefjell is a unique mountain area, unlike any other in the country. Despite having ideal conditions for a wide range of sports (hiking, skiing, fishing, kiting, cycling etc., ) it remains uncrowded, meaning that one can enjoy the vast possibilities of the mountain range without disturbances. Filefjell is the perfect playground regardless of experience. It offers many different routes and difficulties, ranging from some of Norway's most challenging and extreme peaks to easier hikes, and ...
Ideal for couple/honeymooners/nature lovers. 350m to train to Jungfraujoch-少女峰. WIFI.Traditional swiss village with breathtaking views. Centrally located, quiet, cozy room located at 1300m in Wengen. No car access..Easy access to all activities Learn More
Stable, fast, secure wifi available throughout the property. You book a private room, not an entire apartment. Total area of the flat is about 55 square meters and is composed of 2 bedrooms+1 living room/kitchen+1 washroom/WC+ 1 patio (15 additional square meters). More details about the property: Main door: the main door is equipped with an electronic door so no need to exchange keys for check in and check out as I will send you a code in a private message. No need to carry your keys wh...
Cozy and updated condo with all the amenities. A short drive or free shuttle to world class skiing at Keystone or Breckenridge. In the summer enjoy hiking, mountain biking, fishing and water sports on Lake Dillon. Learn More
Recently remodeled with a modern touch, we love our cozy condo. It sleeps 4 comfortably with a queen bed and sofa sleeper. Additional blow up mattress if there is even more in party. We were living in Denver and saying we love the outdoors, the beautiful hiking, fishing, camping, skiing etc... all of what Colorado has to offer. Except we hated spending hours in traffic to get to it. This is the perfect jumping off point for that or if the weather is bad curl up on the couch and watch movi...
Hi. We invite you to our home on the countryside of North-East Iceland. The house is surrounded by a beautiful yard equipped with a big deck, a small pond to play in and not to mention the view, we are a ten minute drive from Akureyri. Be welcome. Learn More
We offer three two man bedrooms with a shared bathroom and refrigerator. The house is located in a hillside just outside of Akureyri. We have a big yard around us which gets colorful during the summer. There is a large front deck where we have a barbeque grill and a pond that can be filled with water. Inside we have a kitchen and a large living room area with plenty of seating pace and a television. Then there are four bedrooms, one of which is occupied by my husband and me, the other three...
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Dell xps 15 i7
I sell my laptop with all accesories, 2 boxes, 1 charger, 1 screen protection!
I sell my laptop with all accesories, 2 boxes, 1 charger, 1 screen protection!
Yoga 2 Lenovo in good condition - 8gb ram 500gb hard drive Touch screen can used as tablet if needed
There is no Price on this item as im just letting people post there offers for it. We brought this new for £200 from PC world about a year ago. Perfect for work or school. Collection only. Send me your offers.
Excellent condition Lenovo ThinkPad Helix ultrabook, core i7 processor, 256GB SSD hard drive, 8GB of RAM. Detachable full-HD touch-screen (1920x1080) for tablet-mode operation; combines the power of an ultrabook with the flexibility of a tablet. Four
bought few days ago, used only once,selling as i need a desktop pc Specifications: Product Description Lenovo Thinkpad T520 Intel Core i5-2520M 2.50GHz ,4GB ,320GB ,15.
Microsoft Surface Pro 2 128GB Fully working Some scratches to the back (see pics), otherwise in very good condition. Collection from Tunbridge wells.
Good condition laptop overall. Battery capacity isn't great but you can buy a new one online for a good price these days. Very nippy core i5 laptop with metal casing. Very durable and well built. Has an nightlight installed at the top of the scr
Dell latitude business laptop for sale. It comes with a fresh installation of windows7, office 2013, 2gb ram, intel core 2 duo 2ghz processor, dvd/cd reader/writer, 15.4 inch screen, wifi built in, bluetooth, avg antivirus, charger, a small chip on t
IBM thinkpad t410 for sale. It has been refurbished and comes with an intel i5 processor at 2.4 ghz (equivalent to 12ghz, hence very fast machine), 3gb ram, 320gb hdd, wifi, sd card reader, webcam, 3G optional and dvdrw built in. It has a fresh inst
Dell business latitude laptop for sale. It comes with an intel core 2 duo processor running at 1.8ghz, 2gb ram, wifi built in, 3G optional, dvd/cd reader/writer, 14 inch screen, fresh installation of windows 7 ultimate, office 2007,avg antivirus, dua
Toshiba satellite laptop for sale. It has been refurbished and runs like a new pc with windows 7,office 2007, intel pentium dual core 2ghz processor, 1 gb ram, 15.4 inch screen, dvdrw, avg anti virus (free forever), 120gb hard drive, all working exce
Acer notebook pc for sale. It runs on an intel atom 1.6ghz processor, 1 gb ram, 120gb hdd, sd/mmc card reader, wifi & webcam built in, good battery, charger, office 2013, win 8.1 and finally comes with 1 month warranty (void if seals are broken).
Hp probook laptop for sale. It has dual windows option at boot up from which you can opt to load windows 7 or windows 10 (see picture). It runs on an AMD turion duo 2.3ghz processor, 2gb ram, wifi buit in, 15 inch screen, dvdrw. Office 2007 and avg
Hp elitebook 8470p 3rd generation i5 for sale. It has intel core i5-3320 @ 2.6ghz each (very fast laptop), 12gb ram (see picture, can be upgraded to 16gb ram), 500gb hard drive, original DVD loading disk, finger print reader, webcam built in, light p
Hp elitebook 8440p laptop. It runs on a fast intel core i5 processor 2.4ghz each (equivalent to 12ghz, hence very fast laptop), built in webcam, 14 inch Hd anti glare display, 2gb ram (can be upgraded for an extra fee), fingerprint reader, dvdrw, sd/
Hp laptop for sale. It comes with an Amd 64*2 dual core processor running at 1.7ghz, 1.5gb ram, 80gb hdd, wifi, webcam built in, nvidia graphics, dvdrw,wifi, windows 7,office 2007, avg antivirus, refurbished and runs like new,battery holds charge for
Alienware 15 gaming laptop for sale. Only purchased in February 2015 with very high specs (see below). Came with one year warranty at the time so approximately six months left at time of listing. Sad sale really. It doesn't get used often enough
This is still in amazon 229 brand new. Just 145 from me. In immaculate like new condition. C50d b 120. Windows 8.1 with option for free update to windows 10.
All working perfectly. 17 inch. Battery lasts for around 1 hour on wifi. Blu ray drive.
Used but in excellent condition, has very small signs of use but nothing major no cracks or big scratches. Very fast computer in excellent working order. Very good battery Everything works perfectly. You will not be disappointed. Specific
This listing is for a Medion Akoya E6227 - 15.6" - 4 GB RAM - 500 GB HDD Laptop. Comes with Windows 7. Wireless. Supplied with original, genuine Medion Charger and Battery that holds charge. If you'd like to check specs for this laptop check
Acer revo pc home theatre systym blue ray dvd cd drive sd drive hdmi usb x 3 vgc hardly used , has its own mini keyboard & mouse cost £495
I'm selling my Aspire 5742 in excellent condition, comes with the charging cable and a fresh installation of Windows 7 Pro (32bit). Selling simply because I don't get to use it that often and I think it could be better used with a new owner. Intel
A very good and well looked after laptop with 250 gb hard drive and 2gb ram with the New Windows 10 pro. All ready to be used!
CPU : CORE 2 XTREME X9000 @ 2.80 Ghz GPU : DUAL NVIDIA 8700M GTX 512MB X2 = 1GB RAM : 4 GB COMES WITH ALIENWARE BAG AND INSTALLATION DISCS
NEEDS A HARD DRIVE CPU : 1.80 ghz - AMD TURION GPU : ATI XPRESS 2600 RAM : 2 GB
NEEDS A BACKLIGHT FOR SCREEN - NON WORKING SCREEN Windows® 7 Home Premium 64-bit (pre-installed, Toshiba-HDD recovery) and Intel® Pentium® Processor T4300 39.6cm (15.6") , Toshiba TruBrite® HD TFT High Brightness display with 1
Good condition Toshiba Laptop CPU : PENTIUM DUAL CORE T3400 @ 2.16 Ghz GPU: MOBILE INTEL 45 EXPRESS RAM: 4 GB HARD DRIVE : 150 GB
Great condition Mac book pro selling because I am saving up for a Windows PC. All working tuning the latest operating system please call or text.
Great laptop fast relaiable good condition going for cheap as doing a clear out needs an hardrive as i took out mine as loads of photos thanks


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rebels and considering more direct intervention, particularly if chemical weapons might be used. I'm not saying the West is not hypocritical, simply look at Rwanda in the 90s, but Syria is not a case for that. And I would argue the west has been more pro liberal democratic everywhere than anything else in the last 4 or 5 years.
U.S. House Speaker Boehner brushes off call for his ouster (Reuters)


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The best restaurant I have visited. Fantastic in all respects. Particularly loved the chicken liver cereal and sea trout course. Highly recommend.
3 Days in Birmingham
Best Food in Birmingham
Shopping Guide for Birmingham
I think the title summarises quite well. My partner and I visited last Friday for a meal out. The service and atmosphere was lovely but the food just didn't have the wow factor. It was nice and well presented but just not great especially when you compare with places we have been for a similar price. My advice - save...
I loved this place it left me wanting more the service was fantastic and the food was superb would recommend this place to anyone
We loved every course. Everything tasted great and we had just enough on every course for what we wanted. The staff were friendly and appropriate good at gauging just what we wanted.
It's about time that somebody wrote a Trip Advisor review of Carter's of Moseley that does this marvellous restaurant justice. Following our latest, exquisite dinner at Carter's, I reached the conclusion that it may as well be me. I hope that the following fits the bill.
I think I may as well state up front that I believe Carter's of...
We went to Carters of Moseley just over a month ago now for my birthday and found a gem. We tried a variety of exquisite food from the tasting menu and I had one of my favourite ever glasses of wine, the Umbrele Sauvignon Blanc. The service was friendly and helpful without being intrusive. I see that it has been...
I was taken here by a business friend and had a fantastic experience. Course after course of inventive, delicious food was brought to our table. I would not hesitate to recommend this fine restaurant - i wish it was closer to home!
Had heard great things about Carters for a couple of years but never ventured that far out of town!
Should have gone sooner. We had a couple of drinks first in Moseley village, which was vibrant and welcoming, before heading up the hill to Carters.
There was a limited choice on the fixed tasting menu, but that's what I like...
My better half booked a table here for my birthday and it didn't disappoint.
The black headed gulls egg taster was delicious - only a certain number of eggs can be gathered per year to conserve the species; like most of the ingredients either ethically or locally sourced (or both).
I'm not sure whether the restaurant is Michelin starred or...
No, lunch isn't £28 per head - that's where it starts. If one of you is driving, (me), then it's probably going to be nearer £45, including drinks.
Is it worth it? A definite yes.
This is a friendly restaurant where the service and the food work hand in hand to provide guests with an informative and very enjoyable experience....
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*The Academy of Motion Picture Arts and Sciences' posh Governors Awards dinner, set for Nov. 12, has announced its first-ever Governors Awards Film Series, which consists of three representative films — one each for Oprah Winfrey, who is to receive the Jean Hersholt Humanitarian Award, as well as the two Honorary Award winners, James Earl Jones and make-up artist Dick Smith.
The series kicks off Nov. 9 at the Academy's Samuel Goldwyn Theater in Beverly Hills with a showing of 1973's The Exorcist, in which Smith's work helped transform Linda Blair into a demonic, head-spinning, little terror, as well as appearances by Smith, Academy governor Leonard Engelman, fellow make-up artist Rick Smith and cinematographer Owen Roizman.
The following night, the program will offer Steven Spielberg's 1985 "The Color Purple," for which Winfrey received a best supporting actor nomination. Academy president Tom Sherak will introduce the evening, which will include actress Margaret Avery, who was also nominated for the film in the role of Shug.
The final feature, on Nov. 11, will be 1970's "The Great White Hope," directed by Martin Ritt, for which Jones picked up an Oscar nomination of his own. The program will include Sherak, director Phillip Noyce and actor Courtney B. Vance.
Tickets will be available to the general public beginning Nov. 1 at www.oscars.org and by mail.
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IU to make major donation announcement Friday
Thu., Jun. 4, 2015
Hoosiers head home after 4-2 loss to Maryland #iubase
Sat., May. 23, 2015
Live chat transcript: IU baseball, women's basketball
Fri., May. 22, 2015
Six Indiana teams earn APR recognition
Wed., May. 20, 2015
Sig Ep holds off Black Key Bulls to win Little 500
Sun., Apr. 26, 2015
Little 500: Kappa Alpha Theta wins back-to-back titles
Fri., Apr. 24, 2015
Fri., Apr. 24, 2015
Hanner Mosquera-Perea provided a glimpse of his potential against Florida Atlantic, Dustin wrote.
IU athletics is the gift that keeps on giving to Hoosier fans, I wrote.
The Hoosiers' Remy Abell took time for a Q&A with Matt Denison of the Louisville Courier-Journal.
Indiana comes in fifth in the latest top 25 and one from CBSsports.com's Jeff Goodman and Gary Parrish.
With IU and Michigan national title contenders, the Big Ten is the best conference in the nation, Mike DeCourcy of the Sporting News writes.
If the NCAA Tournament started today, Indiana would be a No. 2 seed, Rick Bozich of WDRB.com writes.
Initially ruled ineligible for the season, Texas' Myck Kabongo had his suspension reduced to 23 games and must pay back $475, Yahoo! Sports reported.
Bing Crosby and David Bowie with "Little Drummer Boy/Peace on Earth."
Cutter In Chicago #1
The Bing and Bowie duet remains inscrutable to this day. That said, it's a guilty pleasure
Seahawk Tom #2
Merry early Xmas to everyone, and especially Colts fans, who are witnessing a pretty miraculous year (although if the Indy Star comment section is any indicator, there really aren't many Colts fans, or if there are, they don't use computers that much).
Tomahawk Sean #3
Or they don't use computers to write in that comment section using many fake names like you do. Is that what you meant? Dingbat.
Laffy #4
Excellent song choice.
Hope everyone, including HH, has a great Christmas.
Aruss #5
Jeremy with the cornball Xmas song.
Seahawk Tom #6
Eat my fanny, Remorico!
Harvard for Hillbillies #7
Merry Christmas to all,
Geoff #8
Merry Christmas!
Harvard for Hillbillies #9
'Christmas Long Agos'
To run through the powder of new fallen snows,
To sip hot cocoa with melted marshmallows,
To put on three layers of socks and still have cold toes,
To clutch my speeding sled with fingers froze,
And brave the steepest hill to see how fast it goes,
Bring me back Christmas, Christmas long agos.
To look into my yard and dream through an icy window,
To build my first play fortress in natures white pillow,
To welcome the wind's howl when against our house it blows,
To know drifts piled high force school's doors to close,
To never worry of today and have so many tomorrows,
Bring me back Christmas, Christmas long agos.
To watch mom and dad sneak kisses under mistletoea,
To peek at my presents without tearing the bows,
To share a cookie with my dog, my protector from foes,
To feel again his playful nudge and his tongue lick my nose,
To be young and so lucky, like no lucky child knows,
Bring me back Christmas, Christmas long agos.
To see my sisters faces while festive candle glows,
To each a beautiful bloom, a pedal of mother's rose,
To hold forever laughter in a family picture pose,
To watch dad snap a photo when only his sweet grin shows,
To never think such moments together time so soon outgrows,
Bring me back Christmas, Christmas long agos.
Now, how I wish for the first fallen snows,
And the winter's winds of past, through this door to blow,
At the base of the hill grips a tired lonely soul,
Talks to a flickering candle for a change of heart its old glow,
To revisit the sled and the warmth of shivering toes,
To bring me back to Christmas, Christmas long agos.
Old Sports Dude #10
The really unusual thing about this pairing is that it was filmed prior to October 1977 and Bing died in October of 1977. It was shown about a month or so after his death. Thus his last Christmas special was shown when he had passed away already.
Still a classic though and one I have on one of my many Christmas cd's.
Rico Chet #11
Seahawk/Husky Irate Tom:
Enough said. Merry Christmas to you too!
Regardless if he wins over 50% of his games, he provided the groundwor [...]
Kevin Wilson is going to be successful at IU. The question is will he [...]
A couple of comments in response to the posts above. 1) IU has not pl [...]
Shut Up! [...]
Oh, I am sure a few more excuses can be made. [...]
Wow, that's an extremely favorable Big Ten schedule. No more excuses. [...]
The way I see it, being picked last in this poll is a best case scenar [...]
Find Kentucky basketball coverage on VaughtsViews.com - Find Notre Dame football coverage on NDInsider.com. © Hoosier Times Inc., all rights reserved.


text:
just so beautiful, when you are in LOVE.
nice card
Beautiful card for my beautiful man. Thank you
its true nd its realy vry sweet
very cute...awesome..
this card was very cute
very much romantic
So touching for my lover...
nice words
Send this heart ecard to your wife, lover, sweetheart or partner...
A perfect romantic ecard to express your love!
A cute teddy ecard hug for your love!
A cute way to let your special one/ sweetheart know how you feel.
A fun way to tell your sweetheart/ spouse that you both make a perfect pair.
A passionate romantic card to express your warm love emotions!
A beautiful romantic expression of love for your special someone.
Send this ecard to that special person in your life!
A beautiful 'I love you' card.
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Cute ecard for your special someone to convey your true feelings for him/ her.
Say miss you with this character.
Love ecard for all lovers. Send this ecard and express your emotions.
Send your love this romantic card.
Please wait...
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Condes De Albarei Albarino Pazo Baion Single Vineyard 2011
Condes De Albarei - Galicia - Spain - Rias Baixas
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Additional Information on Condes De Albarei Albarino Pazo Baion Single Vineyard 2011
Condes De Albarei
Vintage: 2011
The year 2011 was an interesting year for many northern and central European countries, as the weather was more than unpredictable in the spring and summer. However, in most countries, the climatic conditions thankfully settled down in the late summer and fall. The result of this slightly difficult year of weather in France was a set of surprisingly small yields, but overall, these yields were of a higher quality than those harvested in certain previous years. A fantastic set of wines was also made in Italy and Spain, and the Rioja wines - when released - are set to be very good indeed. Austria also had superb year in 2011, with almost fifty percent more grapes being grown and used for their distinctive Gruner Veltliner wines than in the year before. Possibly the European country which had the finest 2011, though, was Portugal, with wineries in the Douro region claiming this year to be one of the best in decades for the production of Port wine, and the bright, young Vinho Verdes wines. In the New World, the Pacific Northwest saw some of the best weather of 2011, and Washington State and Oregon reportedly had a highly successful year, especially for the cultivation of high quality red wine grapes. Chile and Argentina had a relatively cool year, which certainly helped retain the character of many of their key grape varietals, and should make for some exciting drinking. South Africa had especially good weather for their white wine grape varietals, particularly Chardonnay and Sauvignon Blanc, and many South African wineries are reporting 2011 as one of their best years in recent memory.
Varietal: Albarino
Whilst the pale skinned grapes of the Albarino varietal can now be found in many countries around the world, it has its origins in Spain, where it is still grown in huge numbers today and used to produce excellent quality white wines typical of that part of Europe. Said to be a clone of the French Savagnin grape, Albarino thrives in humid, hot climates and is revered for its light body, high levels of acidity and superb flavors Most commonly, Abarino varietal grapes are famed for their aromatic qualities, and hold notes of bright, soft summer fruits such as apricots and peaches. The wines made from this varietal are pleasantly acidic, light in body and have a tart, sharp bitterness which is excellent alongside many Spanish foods.
Region: Galicia
Galicia, in northern Spain, was once a prosperous and highly popular wine producing region. Despite the strong influence and often bad weather brought by the Atlantic Ocean, the vintners of Galicia knew how to make the most of the grape varietals which thrived in their vineyards, and were renowned for producing excellent, characterful wines full of flavor and beautiful aromatic qualities. However, the economic collapse which occurred in Galicia in the 19th century all but destroyed the region's wine industry and reputation, and it looked as though the region would never recover. Thankfully for lovers of Spanish wines, plenty of money and effort was spent in rebuilding the Galician wine industry over the past few decades, and today, more and more wineries are once again making their distinctive single variety and blended white and red wines, and finding new fans across the globe.
Country: Spain
From the deep and intense Rioja wines, or the dry and refreshing Ruedas, from Tempranillos to Verdejos, the range and quality of Spanish wines is always going to impress and fascinate. With several thousand years of traditions and expertise leading the way, Spanish wineries are currently producing some of the most flavorful and interesting wines to come out of Europe, striving to overcome the reputation problems the country suffered in the mid to late twentieth century. Despite being one of the largest producers of wine in the world, with billions of bottles being filled each year, Spanish wine producers are more interested in quality over quantity than ever before. The results of this are some truly world class wines rivaling even the finest produce of France in regards to balance, character and flavor, gaining new fans and enthusiasts every day.
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The Aventine at Aliso Viejo
- Work 1-949-445-6748
- Aliso Viejo, CA
- 33.578421 -117.7379
- Work 1-949-236-6492
- Irvine, CA
- 33.684078514631 -117.83783865565
Serrano Highlands
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- Lake Forest, CA
- 33.657476 -117.685817
Villas Antonio Apartment Homes
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- Rancho Santa Margarita, CA
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847 Apartments for Rent in Laguna Niguel, CA
Of the 847 apartments in the Orange County metro, we found exactly 25 apartments for rent in Laguna Niguel and 220 apartments nearby. Refine your search by using the filter at the top of the page to view 1, 2 or 3+ bedroom apartments for rent in Laguna Niguel as well as cheap apartments, pet friendly apartments, apartments with utilities included and more. Use our customizable guide to refine your options for apartments in Laguna Niguel and find exactly what you want during your Laguna Niguel, California apartment search.
Pointe Niguel29781 Niguel Road Laguna Niguel, CA 9267733.531242786668 -117.71805079798+−Preview DetailsCollapse Details
Welcome home to Pointe Niguel in the city of Laguna Niguel. Spacious one and two bedroom floor plans, 2 Resort Style Pools, Nine foot ceilings, Full-size washer & dryer connections and Garages, some with direct access.
- Sun Terrace and Gazebo
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- Oversized Dual Master Suites
- Culinary kitchens with garden windows
- Professional On-Site Management
Windridge24922 Hidden Hills Road Laguna Niguel, CA 9267733.52569416 -117.69534721+−Preview DetailsCollapse Details
Windridge Apartments in Laguna Niguel is just 2 Miles from 73 and I-5 (San Diego Frwy) and just north of Dana Point. Offering two and three bedroom apartments for rent.
- Washer/Dryer in Unit
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- Garages Available
- Gated Entrance/Gated Community
- Pet Friendly
Laguna Serrano30001 Golden Lantern Laguna Niguel, CA 9267733.528085 -117.685637+−Preview DetailsCollapse Details
Laguna Serrano offers 1, 2 & 3 bedroom apartment homes for rent in Laguna Niguel, CA. The Laguna Serrano lifestyle includes recreation with two sparkling pools and spas, a fitness center with 2 life steps, 2 life cycles and a treadmill.
- 1, 2 and 3 Bedroom Apartments For Rent
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Apex Laguna Niguel27960 Cabot Road Laguna Niguel, CA 9267733.557956 -117.679212View All Floor Plans+−Preview DetailsCollapse Details
Come home to Apex Laguna Niguel. We offer spacious Studio, 1, 2, & 3 BR apartment homes with many amenities such as a Hotel-inspired pool, SpaClub lounge, Wi-Fi lounge, State of the art fitness studio, Community social programs and convenient access to 405, 73 and Laguna Niguel Rail Station. Penthouses available with upgraded fixtures, high 9' or higher ceilings, Open layout homes, Private balcony, *Private patio, washer and dryer in unit and Luxe kitchens all for your pleasure and convenience.
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- Access to 405, 73, and Laguna Niguel Rail Station
Laguna Gardens24455 Via Pansa Laguna Niguel, CA 9267733.568988 -117.703482+−Preview DetailsCollapse Details
Laguna Gardens Apartment Homes in the city of Laguna Niguel offers 1 & 2 Bedrooms Now Available. You can expect a professional and friendly mgmt. staff and extraordinary floorplans with the best amenities. Sparkling Swimming Pool and Spa, Stackable Washer and Dryer Included.
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- Gas stove
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- Minutes From Fwys.
Serrano Highlands25421 Alta Loma Lake Forest, CA 9263033.657476 -117.685817- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Our apartment homes at Serrano Highlands are charming and comfortable and showcase impressive features. You may choose from convenient one and two bedroom floor plans and villas that offer distinctive amenities that will make you feel right at home including space for full-size washer and dryers, private backyards and direct-access garages with some homes.
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- Fenced in backyards
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- Dishwasher
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- Gas Stove
- Open Daily. Call for a tour.
The Aventine at Aliso Viejo22501 Chase Aliso Viejo, CA 9265633.578421 -117.7379- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
The Aventine features spacious one and two bedroom apartments for rent with amenities such as air conditioning, pool, and spa.Amid the coastal foothills, in the premier master-planned environment of Aliso Viejo, California.
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- Business Center with Office Equipment
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- Outdoor Barbeques
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- 9' Ceilings With Crown Molding
- Custom Walk-In Closets
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- Built in Microwaves
- Refrigerator w/ Ice Maker
Sofi Irvine2750 Kelvin Ave. Irvine, CA 9261433.684078514631 -117.83783865565- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Located in Irvine, Sofi Irvine offers newly remodeled studio, one and two bedroom apartments for rent designed with you in mind and your indoor cat is welcome. Call now to schedule a personalized tour of our community with one of our professional leasing consultants. We look forward to hearing from you!
- Reduced Pricing!!* Select Apartments
- Studios, One And Two Bedrooms
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- Gated Underground Parking
- Two Salt Water Pools/Spas
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- Tennis Court, Gas Barbeques
- Resident Services Online
- We work with Brook Furniture Rental
- Airport, UCI Campus, Movies and Shopping Nearby
Seacrest Apartment Homes240 Avenida Vista Montana San Clemente, CA 9267233.4397194 -117.597788- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Amid beautiful ocean views, rolling hills and a park-like setting, you will find the ultimate resident experience at Seacrest Apartment Homes. This luxurious apartment community reflects a tradition of coastal living and creates an atmosphere of serenity enhanced by gentle ocean breezes, spectacular panoramic views and upscale Mediterranean styling.
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- 9ft Ceilings
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- Granite Countertops
- Microwave
- Mirrored Closet Doors
Club Laguna350 The Club Dr Laguna Beach, CA 9265133.593983277678 -117.75065481663- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Visit today to see our Newly Renovated Interiors and Exteriors! Experience Resort-living at Laguna Beach's only Apartment Community Designed with Every Imaginable Amenity for Year-round Entertainment Club Laguna Apartments is perfectly crafted to satisfy both the free-spirit and go-getter in you.
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- Minutes to Laguna's Main Beach
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- Sand Volleyball
- Resort pool area with Wi-Fi
Park Newport1 Park Newport Newport Beach, CA 9266033.625963850078 -117.88097813044- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Park Newport Apartments
- Short Term Lease Available
- Resort Inspired Amenities
- 10 minutes from John Wayne Airport
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- Putting Green & Playground
- Beautiful Clubhouse w/Private Screening Room
Main Street Village2555 Main Street Irvine, CA 9261433.6824823 -117.8431229- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Main Street Village in Irvine, we're pursuing LEED certification to prove it. Whirlpool Energy Star Dishwasher/ Refrigerator Resort Style Pool w/Private Clubhouse and more. We are Pet Friendly.
- Whirlpool Energy Star Dishwasher
- Whirlpool Energy Star Refrigerator
- CRI Green Label Plus Shaw Tuftex Carpet
- Huge Dog Park
- Pet Friendly
- Premium Parking for Hybrid Vehicles
- Community & Cardboard Box Recycling Programs
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- Club Quality Fitness Center
- Dry Cleaning Service Available
Westridge Apartment Homes26571 Normandale Dr. Lake Forest, CA 9263033.655552229563 -117.66623698294- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Westridge Apartment Homes in Lake Forest with one and two bedroom apartment homes. Easy access to public transportation. Great location
- 1 & 2 Bedroom Apartments For Rent
- Easy Access to Freeways & 241 Toll Road
- Pet-Friendly Community
- Convenient Location Close to Shopping & Dining
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- Newly Renovated Apartment Homes*
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- Hardwood-Style Flooring*
- Two Toned Paint*
- Garages*
- Central Heating and Air Conditioning
- *In Select Apartment Homes
City Lights at Town Center5000 City Lights Drive Aliso Viejo, CA 9265633.57270886512 -117.72747645904- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
City Lights at Town Center in Aliso Viejo offers spacious One and Two Bedroom floor plans with many amenities such as Granite Countertops, Whirlpool Appliances, Breakfast Counters & Pantry.
- Next to Aliso Viejo Town Center
- Spacious One and Two Bedroom Floor Plans
- Wood Flooring in Entry & Kitchens
- Granite Countertops
- Whirlpool Appliances, Breakfast Counters & Pantry
- Laundry Rooms and Walk-in Closets
- Hour Glass Shaped Roman Bath Tubs
- Resort Style Pools with Free Wi-Fi
- Fitness Center, Business Center & Theatre
- Pet Friendly Community
- Huge Private Patio or Balcony
- Parking Structure
Villa La Paz Apartment Homes2 Via Amistosa Rancho Santa Margarita, CA 9268833.647052059141 -117.58012195788- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Your new home awaits you at the serene foothills of the Saddleback Mountains. Our community provides the convenience of ten 24-hour laundry care centers located on-site as well as 24-hour emergency maintenance.
- Central air conditioning and heat
- Pet friendly*
- Sparkling pools and spas (3)
- Recently upgraded fitness centers (2)
- New playground equipment
- 24-hour laundry care centers (10)
- Beach club membership (with deposit)
- Shopping within walking distance
- Excellent school district
- Desirable neighborhood
- Spacious floorplans
- 241 corridor makes commuting easy
Wood Canyon Villa Apartment Homes28520 Wood Canyon Dr. Aliso Viejo, CA 9265633.551655 -117.723012- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Wood Canyon Villa Apartment Homes offers juniors, one & two bedroom Apartments for rent and two bedroom Townhome. While just minutes from Orange County's major business centers, you can live in a community bordered by the serenity of natural, open spaces and cooled by a soothing ocean breeze.
- woodcanyon.rentaladdress.com
- Additional Storage
- Garage
- Air Conditioner (Central)
- Heat (Gas)
- Washer
- Wheel Chair
- Balcony
- Window Coverings
- Cable Ready
- Individual Climate Control
- Large Closets
Sofi Laguna Hills24555 Los Alisos Blvd. Laguna Hills, CA 9265333.60549718823 -117.70265555159- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
With the 5 and 405 Freeway so close to your home at Sofi Laguna Hills, you can build the ideal lifestyle.
- All homes newly rennovated
- Washers/dryers in unit
- State of the Art Fitness Center
- Gated entry
- Private garages*
- Two pools and spas
- Business center
- Decorative Ceiling Fans
- *Select homes
- 2 large swimming pools (1 heated in winter)
- BBQ/picnic area
- E-lounge
Avila at Rancho Santa Margarita22751 El Prado Rancho Santa Margarita, CA 9268833.631865133521 -117.59566746843- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Avila at Rancho Santa Margarita is located where residential neighborhoods, shops, restaurants, movie theaters and business parks combine to create the perfect hometown environment. With 498 apartment homes offering 1 and 2 bedroom options-including dens, Avila offers the perfect floor plan for each lifestyle.
- 1 & 2 bedroom floor plans
- Gas Fireplace
- Walk in closet
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- Soaking Tub
- Direct Garage Access
- Clubhouse
- Outdoor Pool & Hot Tub
- BBQ Area
- Pet Friendly
- Business Center
- King-sized Bedroom
Sycamore Lane25162 Charlinda Drive Mission Viejo, CA 9269133.607698 -117.692249- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
Comfort, style and convenience, you will find this and so much more at Sycamore Lane Apartment Homes in Mission Viejo, in the hearth of south Orange County.
- http://www.rent-sycamorelane.com
- Ceiling Fan
- Additional Storage
- Carport
- Refrigerators not availale in all units
- Window Coverings
- Private Patio
- Heat (Electric)
- Pantries
- Dishwashers unavailable in studios
- Vaulted ceilings in upstairs units
- Park views
Astoria At Central Park West401 Rockefeller Irvine, CA 9261233.677245 -117.848388- Near Laguna Niguel, CA+−Preview DetailsCollapse Details
To live in an Alliance Community is to enjoy the traditional comforts of a custom home and the convenience of a stylish community. Visit Astoria at Central Park West apartments today and experience what home can feel like.
- Three Designer Finish Packages
- Fischer & Paykel Stainless Steel Appliances
- Drop-In Gas 5-Burner Cook Top
- Elegant Limestone & Honed Marble Flooring
- Stylish Granite Countertops
- Recessed Lighting in Kitchens and Bathrooms
- Full-Size Stackable Washer & Dryer
- Built-In Surround Sound*
- Secure Climate Controlled Wine Vault
- Outdoor Fireplace and Outdoor Cooking & Dining
- State-Of-The-Art Fitness Center
- Oversized Saline Pool & Spa
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text:
Memantine for axonal loss of optic neuritis
- Mohammad Riazi Esfahani,
- Zahra Alami Harandi,
- Morteza Movasat,
- Mojgan Nikdel,
- Mohsen Adelpour,
- Arezo Momeni,
- Hamid Merat,
- Masoud Aghsaei Fard
- … show all 8 hide
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To determine the effect of memantine on axonal loss and visual function during the course of optic neuritis (ON).
Sixty ON patients in a single-center, institutional setting were randomly assigned to the memantine or placebo groups. Patients with first attack of acute unilateral optic neuritis, with visual symptoms of 8 days' duration or less were enrolled in this trial. No patient had known multiple sclerosis, and none had taken immunomodulatory agent prior to or at the time of presentation. For all patients, the following characteristics were recorded and compared at initial presentation and 3 months afterward: visual acuity, retinal nerve fiber layer (RNFL) thickness, visual field parameters (mean deviation and pattern standard deviation), visual evoked potential, and contrast sensitivity.
Fifty-four patients completed the 3-month follow up. There were no significant differences between the placebo and memantine groups for any of the characteristics at initial presentation. After 3 months, the only statistically significant difference between the two groups was in RNFL thickness. Memantine group subjects had higher thickness in nasal (P = 0.01), superior (P = 0.006), inferior (P = 0.01) quadrants and average (P = 0.01). However, temporal quadrant thickness was not different between two groups (P = 0.35).
Memantine was effective in reduction of RNFL thinning, although this structural difference was not associated with improved visual function.
- Title
- Memantine for axonal loss of optic neuritis
- Journal
Graefe's Archive for Clinical and Experimental Ophthalmology
Volume 250, Issue 6 , pp 863-869
- Cover Date
- 2012-06
- 10.1007/s00417-011-1894-3
- Print ISSN
- Online ISSN
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Keywords
- Optic neuritis
- Optical coherence tomography
- Retinal nerve fiber layer
- Memantine
- Industry Sectors
- Authors
- Mohammad Riazi Esfahani (1)
- Zahra Alami Harandi (1)
- Morteza Movasat (1)
- Mojgan Nikdel (1)
- Mohsen Adelpour (1)
- Arezo Momeni (1)
- Hamid Merat (2)
- Masoud Aghsaei Fard (1)
- Author Affiliations
- 1. Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Quazvin Sq., 13366-16351, Tehran, Iran
- 2. Qazvin University of Medical Science, Qazvin, Iran


text:
restaurant manager jobs near Franklin, TN
Executive Chef - 2 Yrs Management Exp RequiredNEW
Sodexo- Nashville , TN
Sodexo campus services is seeking an experienced Executive Chef 2 at Belmont University, Nashville, Tn. The Executive Chef will have responsibility for all front of the house...3 days ago from Sodexo
Restaurant Supervisor - Nashville Airport Marriott (150015FR)NEW
Marriott- Nashville , TN
Nashville, TN 37214 is currently hiring a Restaurant Supervisor.Responsibilities ... injuries, and unsafe work conditions to manager; and complete safety training and...2 days ago from Get Food Service Management Jobs
Host/Hostess for the Cascades Restaurant - Gaylord Opryland Resort & Convention Center (150011ET)
Marriott- Nashville , TN
hiring a Host/Hostess for the Cascades Restaurant.Responsibilities include: Greet ... injuries, and unsafe work conditions to manager; and complete safety training and...18 days ago from Get Food Server Jobs
Assistant General Manager - Courtyard Nashville Airport (15000YXX)
Marriott- Nashville , TN
is currently hiring a Assistant General Manager. Responsibilities include: ... performance expectations with the General Manager. Assists team supervisors with...17 days ago from Get Resort Jobs
Assistant Manager Call Center - Gaylord Opryland Resort & Convention Center (15000YEA)
Marriott- Nashville , TN
TN, 37214 is currently hiring a Assistant Manager Call Center.Responsibilities include: ... from an accredited university in Hotel and Restaurant Management, Hospitality, Business...8 days ago from Get Resort Jobs
Restaurant Manager - Old Hickory Steakhouse
Marriott- Nashville , TN
*CORE WORK ACTIVITIES* *Managing Restaurant Operations* • Executes Food and Beverage ... *Restaurant Manager - Old Hickory Steakhouse* **Location:** *TN-Nashville-Gaylord Opryland...30+ days ago from Marriott
Assistant Restaurant Manager Wildhorse Saloon
Marriott International- Nashville , TN
Food Service Management, Hotel and Restaurant Management, Hospitality, Business Administration, or related major; 1 year experience in the food and beverage, culinary, or related...30+ days ago from Marriott International, Inc
Restaurant Operations Manager
Marriott- Nashville , TN
if applicable. Supervises daily restaurant operations and assists with menu ... Food Service Management, Hotel and Restaurant Management, Hospitality, Business...30+ days ago from Marriott
Restaurant SupervisorNEW
Marriott International- Nashville , TN
injuries, and unsafe work conditions to manager; and complete safety training and certifications. Ensure uniform and personal appearance are clean and professional, maintain...1 day ago from Marriott International, Inc
Food Operations Manager 3NEW
Sodexo- Nashville , TN
to the General Manager, the Operations Manager will oversee a dedicated, talented ... Assumes General Manager's (GM) responsibilities and authority in his/her absence in comple...4 hours ago from Sodexo
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text:
London police say a helicopter has crashed during a rush hour in central London after apparently hitting a construction crane on top of a building.Please bookmark!
"It is too early at this stage to confirm any casualties," Metropolitan Police said in a statement.
A photo shown on Sky News showed wreckage burning in a street, and a large plume of black smoke was seen rising in the area.
London Fire Brigade said it was called at 8 a.m. to a report of a crash on Wandsworth Road on the south bank of the Thames.
Nigerian Troops Rescue 178 People, Mostly Children, Kill Large Number Of Boko Haram - Feel good story of the day. Via Fox News: Nigerian troops rescued 178 people from Boko Haram in attacks that destroyed several camps of the Islamic extremi...
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After NBA finals, will Heat do a cooldown?
Jeff Horwich
Interview by
Jun 22, 2012 The Miami Heat, in five games, won the NBA championship last night by... a lot. From a strictly business point of view -- what now?
Miami Heat tickets are red-hot
Kenny Malone
Jun 21, 2012 It's the last game of the year in Miami, and the Heat could clinch the NBA title tonight. So have fun trying to pay for a ticket.
Playing the name game
Adriene Hill
Jun 12, 2012 The NBA finals will be played in two arenas named for a couple of less-than-stellar corporate performers.
NBA viewership up despite shortened season
Amy Scott
Jun 12, 2012 Jeremy Lin and other dramatic storylines have more people watching.
Why more athletes are choosing to sport eyewear
Stephen Dubner
Interview with
May 30, 2012 It turns out NBA players like LeBron James don't actually need the eyeglasses to see.
Miami hardware store swears off the penny
Tess Vigeland
Interview by
May 28, 2012 Miami Herald reporter Douglas Hanks on why a hardware store has decided to get rid of the penny and what it's done for business.
L.A. pro teams pull postseason hat trick
Eve Troeh
May 17, 2012 The Lakers, the Clippers and the Kings all in the playoffs at the same time this year. That spells big money for the Staples Center and busy times for the people who transform the sports arena from a basketball court to hockey rink.
Is the all-you-can-eat model ever a good idea?
David Lazarus
Interview with
May 9, 2012 Unlimited data plans, unlimited airline miles, all-you-can eat buffets -- looking at the logic (or lack of) behind companies that launch all-you-can-eat plans.
Do airline mergers deliver on their promises?
Stacey Vanek Smith
Apr 26, 2012 It's rumored that US Airways may soon merge with the bankrupt parent company of American Airlines. Mergers usually bring promises of frequent flier guarantees and hub airport assurances, but do they actually happen?
American Airlines bankruptcy could void union contracts
Bill Zeeble
Mar 26, 2012 The parent company of American Airlines wants more concessions from unions, or it'll push to cancel existing labor contracts.