text:
Forum - View topicINTEREST: One Piece's Thousand Sunny Roll Cake Offered in Japan
Note: this is the discussion thread for this article
|View previous topic :: View next topic
Collector Extraordinaire
Posts: 1008
Location: Richmond, B.C., Canada
|I'm not a One Piece fan, but that cake sure looks good. Me, I could definitely go for the Evangelion NERV headquarters and roll cakes. Yum!
|Back to top
Surrender Artist
Posts: 3197
Location: A damned nation
|This sort of stuff is nice and all, but the real money has to be in a jelly roll actually shaped like Rei Ayanami.
|Back to top
Emma Iveli
Posts: 441
Location: San Francisco CA
|I'm pretty sure I said this before. but those aren't forks. They're sporks. There's a difference.
|Back to top
leafy sea dragon
Posts: 2085
Location: Canterlot Suburbs
Wow, that's one seriously expensive cake. What do they do, personally deliver it to you?
Nevertheless, those are some pretty nice sporks. Must be quite the collectors' items.
|Back to top
The American Average
Posts: 581
Location: In the World between this world
|looks cool. wouldn't buy it myself but hey somebody does otherwise they wouldn't make it.
|Back to top
Posts: 522
That's more then slightly adorable.
If I lived in Japan, I'd maybe think about springing for one, mainly because the release coincides with my sister's (and fellow One Piece fan) birthday.
But damn that price tag.
|Back to top
Posts: 6406
Location: Maine
That's what I was thinking as soon as I saw the pic, definitely sporks.
Also as good as the cake looks, it appears to be really tiny compared to the tea cup next to it. Kinda pricey for a cake that may feed only two people. I wonder if people are just buying this for the sporks and Sunny parts to make their own cake.
|Back to top
Posts: 24
|One Piece mania never ceases to amaze me. =D
|Back to top
|Anime News Network Forum Index -> Site-related -> Talkback
All times are GMT - 5 Hours
|Page 1 of 1
Powered by phpBB © 2001, 2005 phpBB Group
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum
The List - 7 Eras of Japanese History via Anime
Travel back in time (and maybe have your gender swapped) to seven different periods of Japanese history, all from the comfort of your couch. ― The history of Japanese civilization is expansive, predating the Common Era by 10,000 years (the Jomon period). There's much more ground to cover compared to what kids get in U.S. history classes in high school, which rarely cover anything before the Boston T...
Gyo [2-in-1 Deluxe Edition] GN
Junji Ito's death-stench horror gets the deluxe treatment with a new hardcover omnibus, but the subject matter might not work for everyone. ― Junji Ito is inarguably one of the masters of horror manga, utilizing both horror (physical revulsion) and terror (psychological reaction) to create gut-churning tales of the world gone mad. To a degree, he carries this out in his two-volume series Gyo from 200...
ANNCast - Podcastoes O'Brien
Voice actor/director/professional Dungeons & Dragons player Liam O'Brien returns to the podcast after a 5-year hiatus to discuss his roles in Fate/Zero and Sailor Moon, along with the landscape for anime voice acting now and what it's like to be Gollum. ― ANNCast Episode 234: Podcastoes O'Brien Get the Flash Player to see this player. Voice actor/director/professional Dungeons & Dragons player Liam ...
Why Are Anime Fans Obsessed with Steven Universe?
If you went to an anime convention this summer or have used the internet lately, you may notice anime fans seem to have fallen in love with Steven Universe. Why? Because the show loves them right back. ― If you've been to an anime convention in the past year, you've probably seen colorful, gem-studded cosplay like this filling the hallways. Photo credit links: top left, top right, bottom left, bottom...
We Need Your Questions for the Director of The Pilot's Love Song
If you've got questions for the director of the high-flying fantasy series The Pilot's Love Song, we've potentially got answers for you! ― We've been given the opportunity to interview The Pilot's Love Song director Toshimasa Suzuki, and we need your help! NISA, who will be releasing the fantasy action drama The Pilot's Love Song on bluray September 22nd, asked for fan questions for Mr. Suzuki, whos...
Noir Blu-Ray
Bee-Train's 2001 girls-with-guns classic returns on Blu-Ray, and holds up surprisingly well, despite some mediocre animation. ― Not all older series deserve the Blu-Ray treatment. For some it is because the show just isn't as iconic as people might like to think, while for others it's because the quality was never BD worthy in the first place. Noir, fortunately, does hold up well enough that its tran...
Anime Spotlight - SHIMONETA: A Boring World Where the Concept of Dirty Jokes Doesn't Exist (Shimoneta to iu Gainen ga Sonzai Shinai Taikutsu na Sekai)
The revolution is about to begin! ― SHIMONETA: A Boring World Where the Concept of Dirty Jokes Doesn't Exist (Shimoneta to iu Gainen ga Sonzai Shinai Taikutsu na Sekai) Visit the Official Site › Story Characters Trailer Cast & Staff Gallery Broadcast Begins July 4, 2015 (JST) Key Staff Director: Youhei Suzuki (The Hentai Prince and the Stony Cat ) Series Composition: Masahiro Yokotani (Free! Eternal...
JoJo's Bizarre Adventure: Stardust Crusaders Egypt Arc [Episodes 1-24 Streaming]
Egypt Arc is JoJo in peak condition, as memorable and engaging an adventure as you could hope for. JoJo's Bizarre Adventure is back. ― When we last left our heroes, they'd just arrived on the shores of Egypt, escaping the literal jaws of defeat in order to finally save Jotaro's mother. The journey there had been a lengthy and sometimes inconsistent one, with their various adventures indeed being plen...
Interview: Yamada-kun and the Seven Witches creator Miki Yoshikawa
The creator of the hit manga, recently adapted into a popular anime series, talks about her inspirations, how she got her start, and what it's like to watch your manga become a TV show. ― As you might guess from the story, the main character of the story is a high school roughneck named Ryu Yamada. Yamada meets cute, quiet, and studious Urara Shiraishi, who is his complete opposite in almost every wa...
Anime Spotlight - To loveru -Darkness 2nd
After a brief break To Love Ru Darkness returns for a second season! ― To loveru -Darkness 2nd Visit the Official Site › Story Characters Trailer Cast & Staff Gallery Broadcast Begins July 6, 2015 (JST) Key Staff Director: Atsushi Otuski (Argevollen, Ladies versus Buttlers!) Character Design: Yuchi Oka (Argevollen , Motto To loveru) Music: Takeshi Watanabe (Strike the Blood, Saki) ↑ Top Story The fo...
Sword Art Online: Progressive Novel 2
Kirito's adventures continue in Reki Kawahara's second Progressive novel, which delves into the mechanics of the game much more than the show ever did. ― The second volume of Reki Kawahara's ambitious reimagining of Sword Art Online offers plenty of intriguing content, but perhaps none more so than its Afterword. In the Afterword for the first volume, he mentioned an intent to average about two floor...
Five Steps to Better Fanservice
Everyone loves fanservice - except, as the common wisdom goes, anime critics. Paul Jensen dismantles this age-old assumption with a recipe for how good fanservice can make a cool show even better. ― Speaking as both a fan and a critic, I'm of the opinion that fanservice is like a spice; just the right amount in the right recipe and it's fantastic, but too much overpowers the dish. Not every anime ser...
The X Button - Heaven Sense
This week: a chat with Final Fantasy XIV producer Naoki Yoshida! Plus Exist Archive, Red Ash, Dragon Quest, and a classic wonder-world! ― Some loyal readers may be tired of hearing about Red Ash, Keiji Inafune's Kickstarter attempt to relaunch Mega Man Legends in just about everything but name and storyline. You must forgive me, as I really enjoy the Legends games and want to see more in their gener...
Anime Spotlight - AOHARU x MACHINEGUN
Hotaru Tachibana is introduced to the survival game world by an eccentric group of friends who may have what it takes to be the best team in Japan. ― AOHARU x MACHINEGUN Visit the Official Site › Story Characters Trailer Cast & Staff Gallery Broadcast Begins July 2, 2015 (JST) Key Staff Director: Hideaki Nakano (Golden Time Episode Director (Eps.7), Yatterman Night Episode Director (Eps.2) ) Series ...


text:
CIRP Annals - Manufacturing Technology
Published by CIRP, The International Academy for Production Engineering
Editor: CIRPView full editorial board
Enter your login details for CIRP Annals - Manufacturing Technology below. If you do not already have an account you will need to register here.
Check submitted paper
Track accepted paper
Once your article has been accepted you will receive an email from Author Services. This email contains a link to check the status of your article. Track your accepted paper
CIRP, The International Academy for Production Engineering, was founded in 1951 to promote, by scientific research, the development of all aspects of manufacturing technology covering the optimization, control and management of processes, machines and systems.
This biannual ISI cited journal contains approximately 140 refereed technical and keynote papers. Subject areas covered include:
Assembly, Cutting, Design, Electro-Physical and Chemical Processes, Forming, Abrasive processes, Surfaces, Machines, Production Systems and Organizations, Precision Engineering and Metrology, Life-Cycle Engineering, Microsystems Technology (MST), Nanotechnology.
Benefits to authors
We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.
Please see our Guide for Authors for information on article submission. If you require any further information or help, please...
Most Cited Articles
- Industrial Product-Service systems-IPS2H. Meier | R. Roy | ...
- Advanced monitoring of machining operationsR. Teti | K. Jemielniak | ...
- Surface integrity in material removal processes: Recent advancesI. S. Jawahir | E. Brinksmeier | ...
Recent Articles
- Metal forming beyond shaping: Predicting and setting product properties
A.E. Tekkaya | J.M. Allwood | …
- Micro additive manufacturing using ultra short laser pulses
Bert Huis in 't Veld | Ludger Overmeyer | …
- Calibration and verification of areal surface texture measuring instruments
R.K. Leach | C.L. Giusca | …

subset: commoncrawl


text:
|Name: _________________________
|Period: ___________________
This test consists of 5 short answer questions, 10 short essay questions, and 1 (of 3) essay topics.
Short Answer Questions
1. How many sons does the father in "Grandmother's Tale" have?
2. What did Chelm need money for?
3. What do the people in Chelm like to do?
4. How does the strange man in "Grandmother's Tale" entertain the children in the house?
5. What is Grandmother's name?
Short Essay Questions
1. What did the strange man do after the children realized who he really was?
2. What strange thing did the children notice while the strange man was playing with them?
3. How does "Grandmother's Tale" begin?
4. What did the strange man who appeared in "Grandmother's Tale" look like?
5. Who is invited as a special guest to Atzel's wedding and why?
6. What does Dr. Yoetz see when he first checks on Atzel inside Kadish's house?
7. What does Atzel do on his first days in paradise, and how does he feel about this?
8. What does Atzel do the minute he is released from paradise?
9. What do Tudras and Lekisch want to buy with the fortune from the snow?
10. Why did someone think the moon fell in a barrel?
Essay Topics
Write an essay for ONE of the following topics:
Essay Topic 1
The characters in these stories have their own goals and motivations. Select four characters and discuss their main motivation and how this goal affected the characters around them.
Essay Topic 2
Hannukuh and Judaism are central to the plots of every story. How does this religious center affect the plot of the stories and the messages presented in them?
Essay Topic 3
Foolishness is a common folly highlighted in this collection of stories. What are some of the main examples of this, and what message is being sent by this blatant foolishness?
This section contains 644 words
(approx. 3 pages at 300 words per page)


text:
Something Smells Fishy -- And Like Rectal Leakage, Too
The Department of Business and Professional Regulation (DBPR) in Tallahasee has doubled the fine for any proven offense of food misrepresention in dining establishments (from $250 to $500, which still doesn't seem like much punishment for deceiving the public -- and increasing profits considerably while doing so). "Floridians ought to be able to trust restaurant owners, and these increased penalties will help us ensure that the food we eat is the food we ordered", says DBPR Secretary Holly Benson.
Seafood seems to be the main culprit in this bait-and-switch tactic. Eight South Florida restaurants -- three in Broward and fgive in Miami -- have been busted. The most common frauds perpetrated are the ones in which grouper is advertised, but pangasius (striped catfish) is substituted; and escolar (a type of mackerel) gets sold as white tuna. This latter swap can be especially messy, as, according to an online encyclopedia: "Gastrointestinal symptoms may include oily orange diarrhea, discharge, or leakage from the rectum that may smell of mineral oil. The discharge can stain clothing and occur without warning 30 minutes to 36 hours after consuming the fish. The oil may pool in the rectum and cause frequent urges for bowel movements due to its lubricant qualities and may be accidentally discharged by the passing of gas.
Symptoms may occur over a period of one or more days. Other symptoms may include stomach cramps, loose bowel movements, diarrhea, headaches, nausea, and vomiting." Because of this, escolar has been banned in Japan since 1977. Our own FDA thinks it's just peachy -- just how powerful is the Depends lobby in this country, anyway?
Here are some local restaurants that between January 1, 2006 and January 30, 2007 were cited by DBPR for "Violation 52: Administrative Complaints for Food Services Misrepresentation" :
Pangasius sold as grouper:
9/13/06 Doral Seafood
12/18/06 El Novillo
1/4/07 La Rosa Restaurant
Pangasius sold as mahi mahi and tilapia:
9/18/06 Lombardi's of Miami
Escolar sold as white tuna:
8/21/06 Moon Thai & Japanese Restaurant (Broward)
9/27/06 Sakura Thai & Japanese Restaurant (Broward)
10/16/06 Iron Sushi
1/22/07 Sushi Rock (Broward)
Get the This Week's Top Stories Newsletter
Every week we collect the latest news, music and arts stories — along with film and food reviews and the best things to do this week — so that you'll never miss Miami New Times' biggest stories.
Sponsor Content
More News
- Poll: Floridians Overwhelmingly Approve of Medical Marijuana, Raising Minimum Wage
Upcoming Events
Palm Beach Cardinals vs. Charlotte Stone CrabsThu., Aug. 6, 6:35pm
Palm Beach Cardinals vs. FT Myers MiracleFri., Aug. 7, 6:35pm
Miami DolphinsFri., Aug. 7, 7:00pm
Miami Dolphins Friday Night FestivalFri., Aug. 7, 7:00pm
- Tickets
- North Beach Residents Fight Back Against 22-Story Condo Tower Proposal
- Doral Considers Revoking Donald Trump's Key to the City


text:
2006 Ford Expedition in Bend, OR
New Search
Filter Results
|- Loading...
|- Loading...
Accidents Reported
Text Search
Add Similar Cars
Choose Other Models to Add
Listings for these models will be added to the listings you are currently viewing.
CarGurus Quick Poll
2006 Ford Expedition Eddie Bauer 4WD Review
|by Nathaniel
"It's comfortable and powerful. Do not purchase this vehicle if you are low on funds!!"
Regardless of anything I may have to say about this vehicle, I like that it was FREE... thanks dad! I think the truck fits me, however the color will be changing to something custom real soon! I average 14/18 mpg... (thanks Mom & Dad for the gas) :)
Featured Listings
2006 Ford Expedition Limited 4WD Used Cars in Bend, OR 97701
Good Deal
$1,858 BELOWInstant Market Value of $10,853
Price: $8,995
Mileage: 157,777
Location: Bend, OR 97701
Average time on market: 18 days Certified Pre-Owned: No Transmission: Automatic Color: Silver Description: Used 2006 Ford Expedition Limited 4WD for sale - $8,995, 157,777 miles with Leather Seats, Alloy Wheels
Avg. Dealer Rating: (4 reviews) "Called back quickly"
2005 Ford Expedition XLT 4WD Used Cars in Eugene, OR 97402
Fair Deal
$223 BELOWInstant Market Value of $9,203
Price: $8,980
Mileage: 126,148
Location: Eugene, OR 97402
Average time on market: 19 days Certified Pre-Owned: No Transmission: Automatic Color: Gray Description: Used 2005 Ford Expedition XLT 4WD for sale - $8,980, 126,148 miles with Tow Package, Alloy Wheels
Avg. Dealer Rating: (7 reviews) "Responded back quickly. They were able to get me through the finance paperwork within just a few hours and get me approved with a very satisfied percent"
2007 Ford Expedition Eddie Bauer 4X4 Used Cars in Bend, OR 97701
High Price
$2,245 ABOVEInstant Market Value of $16,754
Price: $18,999
Mileage: 99,019
Location: Bend, OR 97701
Average time on market: 16 days Certified Pre-Owned: No Transmission: 6-Speed Automatic Color: Copper Description: Used 2007 Ford Expedition Eddie Bauer 4X4 for sale - $18,999, 99,019 miles
Avg. Dealer Rating: (1 review) "We worked with David Moore at Smolich in Bend and got the deal we wanted without any problems. "
Please wait ...
Filter your search criteria!
A large number of listings matched your criteria. You are seeing the top listings.
Similar Cars
Chevrolet Tahoe
401 Great Deals out of 26,746 listings starting at $2,999
Ford Explorer
636 Great Deals out of 39,829 listings starting at $1,295
Lincoln Navigator
70 Great Deals out of 4,726 listings starting at $1,550
New Ford Expedition By Year
2015 Ford Expedition
6,751 listings
Used 2006 Ford Expedition By City
2006 Ford Expedition in Eugene OR
2 listings starting at $6,898
2006 Ford Expedition in Portland OR
6 listings starting at $6,995
2006 Ford Expedition in Medford OR
1 listings starting at $11,998
2006 Ford Expedition in Yakima WA
4 listings starting at $10,995
2006 Ford Expedition in Kennewick WA
6 listings starting at $8,999
2006 Ford Expedition in Redding CA
1 listing
2006 Ford Expedition in Seattle WA
6 listings starting at $6,995
2006 Ford Expedition in Boise ID
3 listings starting at $7,592
2006 Ford Expedition in Reno NV
2 listings starting at $12,172
2006 Ford Expedition in Bellingham WA
2 listings starting at $8,971
2006 Ford Expedition in Sacramento CA
10 listings starting at $7,700
2006 Ford Expedition in Missoula MT
3 listings starting at $13,495
2006 Ford Expedition in Stockton CA
12 listings starting at $7,700
2006 Ford Expedition in Oakland CA
11 listings starting at $7,700
2006 Ford Expedition in San Francisco CA
5 listings starting at $7,886


text:
You are using an outdated browser. Please upgrade your browser to improve your ReverbNation experience.
Slamming, do ya here me tho! Shamel the ShamelRecords.com connection
Great work, I'll be back for more! Stay blessed!
fire!! period!!!
the sound is cool bro good stuff
Great mix on "Roll Up!"
Its dope !!!!! well done!....peace Dain
Keep doing your thing!
Unique style! Nice!
Diggin' your flow & energy... Keep up the good music!
roll up mawfawka!


text:
15-1132 jobs near Arlington, VA
Junior Software Engineer
Parsons- Centreville , VA
Software Engineer Centreville, VA OPPORTUNITY You know that great feeling you get when you solve a really tricky problem with a brilliant solution? We feel that a lot over here.12 days ago from Parsons Corporation
Sr Proposal WriterNEW
Computer Sciences Corporation (CSC)- Falls Church , VA
Plans, coordinates, and prepares proposals, focusing on management and technical responses. Ensures compliant, compelling responses to RFP requirements. Essential Job Functions...3 days ago from Computer Sciences Corporation (CSC)
Service Oriented Architecture Developer
Hewlett Packard- Alexandria , VA
HP Enterprise Servicves is seeking to identify highly motivated and qualified individuals for various future opportunities as a Service Oriented Architecture Software Developer.5 days ago from Hewlett Packard
Lead Software Architect
Next Step Systems- Washington , DC
Keywords: Washington DC Jobs, Lead Software Architect, C++, C#, Java, OOP, Business Intelligence, Washington DC Recruiters, IT Jobs, Washington DC Recruiting Summary Reporting to...5 days ago from The Ladders
Sr. NET/C# Developer - US Citizenship
Computer Sciences Corporation (CSC)- Washington , DC
Looking for a Sr. .NET developer with skills in C#!! Join a growing team supporting DHS in downtown DC/Union Station area. Metro accessible location. - MUST BE A U.S. CITIZEN -...6 days ago from Computer Sciences Corporation (CSC)
Software Engineer
Who we are: Incapsulate provides services from conception to delivery. We are a team of engineers, designers, and analysts who are committed to helping businesses solve problems...12 days ago from Incapsulate
Development, Technical Lead (Microstrategy)
Freddie Mac- Mclean , VA
Position Overview Finance and Data Services is seeking a Development, Tech Lead to lead project delivery and production support for a suite of MicroStrategy BI/Analytics...7 days ago from Freddie Mac
Development Sr.
Freddie Mac- Mclean , VA
Position Overview Freddie Mac has an exciting opportunity for a Senior Level Java/J2EE Developer (Development, Sr.) to contribute to the development and maintenance of Single...7 days ago from Freddie Mac
Rails Software Engineer
JobOn is seeking bright, motivated technology professionals to work with us on our exciting Ruby on Rails development team. Full-time employment or contract to hire depending upon...15 days ago from JobOn Corporation
Frontend Developer
Scom- Washington , DC
Job Overview Job Order: JO000030174 Date Posted: Jul 24 Salary: Industry: Metro Area: Washington, DC Start Date: Aug 10 s.com is looking for a solid front-end Drupal Developer to...8 days ago from scom
Sign Up for Job Alerts
- Booz Allen Hamilton 521
- Leidos 456
- Lockheed Martin 378
- Northrop Grumman 323
- Keyw 307
- General Dynamics 301
- Accenture 242
- Jobspring Partners 228
- Computer Sciences Corporation (CSC) 194
- Smith & Keller 192
- See more >
- High School 252
- Some College 3
- Associate's Degree 162
- Bachelor's Degree 12,746
- Master's Degree 360
- Doctorate 45
- Professional 408
- See more >
- 0 - 2 years 1,150
- 2 - 5 years 3,389
- 5 - 7 years 2,457
- 7 - 10 years 1,773
- 10 - 15 years 769
- 15+ years 50
- See more >
- Veteran Friendly 3,015
- Fortune Most Admired Companies 1,897
- Fortune 500 1,779
- Mom Friendly 1,078
- New Graduate 628
- Diversity Friendly 490
- GLBT Friendly 487
- Fortune Best Companies to Work For 482
- Socially Responsible 294
- See more >
- Exclude Job Boards 7,243
- Job Boards Only 6,329
- Exclude Recruiters 12,135
- Recruiters Only 1,437


text:
"Lack of time" is a major reason families do not go fishing or boating together. Although there are only so many hours in a day, it may be possible to "find" some free fishing time for these stress-relieving, fun, family activities. Here are a few ways to make family fishing time: Stay Organized. Utilize "down-time" (any time not fishing or boating) and make sure all of the fishing lures are sorted (by size, type, or…
boating tips Archives - Take Me Fishing
Feed Directory
- Subscribe to All Posts
Feeds by Category
- Subscribe Boat Launch Posts
- Subscribe Boat Trailering Posts
- Subscribe to Boating Posts
- Subscribe to Boating Basics Posts
- Subscribe to Boating Safety Posts
- Subscribe to Cape Cod Fishing Posts
- Subscribe to Community Posts
- Subscribe to Conservation Posts
- Subscribe to Fishing Posts
- Subscribe to Fishing Gear Posts
- Subscribe to Fishing Massachusetts Posts
- Subscribe to Fishing Tips Posts
- Subscribe to Fishing, Fishing Gear, Fishing Tips Posts
- Subscribe to Outdoors Posts
- Subscribe to Storm Preparation for Boats Posts
Feeds by Tag
- Subscribe to Fishing Tag Posts
- Subscribe to Boating Tag Posts
- Subscribe to Fishing Tips Tag Posts
- Subscribe to Fishing Equipment Tag Posts
- Subscribe to Boat Posts
- Subscribe to Conservation Tag Posts
- Subscribe to Boating Safety Tag Posts
- Subscribe to Boating Tips Tag Posts
- Subscribe to Outdoors Tag Posts
- Subscribe to Tom Keer Tag Posts
Sea Trials: Part 1
One of the best parts of buying a new boat is the series of sea trials that accompany the purchase. The sea trial, also known as a shakedown cruise, is a way to test the boat to make sure that you know if you're buying the one best suited to your needs. Here are 4 points to check out quickly: Speed: Check out how the boat comes on and off plane,…
5 Steps for Easy Boat Registration
So you just bought a boat and are anxious for that first splash. As with cars, boats need to first be registered. Here's how: See who handles the registration process. In some states it's the DMV while in others it's the Parks Division or the Fish and Game Department. Check to find your specific state requirements. You will need to fill out the application forms. Some states accept online registrations…
Local Fishing Information Sources
"90% of all fishing knowledge is local knowledge." – Noted Fly fisherman, Lefty Kreh, from 1001 Fishing Tips by Lamar Underwood Bait or tackle shops are known to be a great source of fishing information, but other businesses may provide a wealth of information as well. In my neck of the woods, it is a rare local business owner or employee that doesn't go fishing and boating. Patronize an establishment in a "Just Keep…
3 Tips for Planning Fishing Trips
Staring out the office window at my rapidly shrinking driveway surface area and ever growing snow banks, thoughts turn to when this annoying stuff finally melts and transforms into enough oxygenated liquid to support my finned friends. Can't wait! This year I've got big fishing plans. For the last two years, I explored and fished from shore or kayak. Only a couple of small streams with limited shore access have been crossed off. With the…
Why it's Important to Check on your Boat this Winter
The recent storms throughout the Northern half of the country have brought rain, wind, ice, and snow. Just to give you an idea about how bad it's really been, in my hometown we had 42 inches of snow in one week, winds of 60 MPH with gusts to 80 MPH, and then rain. The first thing I did when the storm subsided was NOT to grab a shovel. Instead, I check on my boat. The…
"Fish here often?" A non-traditional date on Valentine's Day
Valentine's Day is rapidly approaching and the candy and flowers stores are hopping. Dinner and a movie also are traditional date choices. But, what if you are looking to spice things up a bit? 2/3* of all relationships enjoy the "non-traditional" dating of fishing or boating because it is "relaxing, playful, exciting, and romantic." That's right, romantic. What do fishing and boating have in common? Water. Think of all of those gift card covers and…
Fall Boat Shows
I'm not a tire kicker but I sure act like one. The truth is I hate to rush big decisions. I like to take my time, consider all of the pros and cons, do a lot of research, and work out all of the fine details. When I finally get off the dime I'm in good shape; by that I mean my hand doesn't shake when I sign on the dotted line. Buying a new…
Pre-Owned Boat for Sale
Not mine. I bought a pre-owned boat this summer and we don't plan on parting with it anytime soon. However with cooler temperatures and the boat season winding down in places, some boats may start appearing in the newspaper classifieds. Here are a few considerations in case you may be in the market for a pre-owned boat. ● Are you ready? Do you have a place to store it? Is there room in the garage?…
Whose Zander is Grander?
Fishing from a kayak is great fun. Even if the fish aren't biting, you are still kayaking. This light water craft gets one close to water, yet it is stable and stealthy. Some models even come equipped with a rudder and peddle capabilities so you can keep on casting. If you like kayaking, fish with teeth, and vowels, you should check out the 4th Hobie Fishing World Championship which takes place October 5-11. By besting…


text: Went here for dinner our last night of vacation. Be warned, they do not take call ahead or reservations. My party called before hand and someone mistakenly told us they did. So when we showed up and our name wasn't on the list with a thirty minute wait ahead of us, we were concerned. However, after... read more


text:
Bank robber turned out to be SNU-graduated former teacherIt has belatedly turned out that the accused thief of MG Community Credit Cooperatives in Seocho-gu, Seoul on July 20 used to be a teacher who graduated from Seoul National University (SNU). According to Seoul Metropolitan Police Agency of Seocho ... Donga.com, 14 hours ago
SNU 24th in global university ranking
Seoul National University (SNU) is 24th in the Center for World University Rankings (CWUR) this year _ the same as last year. Yonsei University (98) jumped nine ranks into the top 100. Following were Korea University (115), Korea Advanced ...Korea Times, 5 days ago SNU Ranks 24th in World's University Rankings Korea Broadcasting System, 5 days ago Must-Visit Places in SNU Gwanak Campus Noodls, 1 week ago [Student Essay] Things I Will Never Forget from SNU Noodls, 1 week ago
More from: Donga.com, Donga.com...and 3 other sources
SNU launches microgrid project
The Seoul National University embarked on the migrogrid project for electricity-cutting efforts, the first-ever attempt made by the South Korean university. The Seoul National University and Ministry of Trade, Industry and Energy held its ...Maekyung, 1 week ago Apartment for All: SNU's New House Sharing Project Noodls, 1 month ago
Chinese Embassy donates books, DVDs to SNU
The Chinese Embassy donated 10,000 books to Seoul National University on Tuesday, fulfilling a pledge made by Chinese President Xi Jinping when he visited Korea last July. The donation, which also includes some 750 DVDs, covers traditional Chinese ...Korea Herald, 3 weeks ago Chinese President Donates Books to SNU Digital Chosun, 4 weeks ago
SNU takes initiative in energy-saving efforts
The Seoul National University, which consumes a lot of energy, will embark on an innovative energy-saving initiative through a private/public/ academic joint microgrid project. Microgrids have been installed in remote islands such as Gapado in Jeju, ...Maekyung, 1 month ago
Kolkata: SNU to start admissions for U.G and P.G courses
Kolkata,May 26 (IBNS): Shiv Nadar University, a higher education institution in Uttar Pradesh, has announced admission for Undergraduate and Postgraduate courses for 2015-16 academic year on Monday, in Kolkata. The University offers 14 ...India Blooms, 2 months ago
MagnaChip to Engineer 0.18 micron Automotive Process Technology with ABOV, UNIST and SNU
MagnaChip Semiconductor said it has started the co-development of an automotive MCU process with ABOV Semiconductor, Automotive Electronic Systems and Semiconductors Lab. of UNIST (Ulsan National Institute of Science and Technology) and Analog & ...Individual.com, 3 weeks ago MagnaChip to Develop 0.18 micron Automotive Process Technology with ABOV, UNIST and SNU ThomasNet, 3 weeks ago MAGNACHIP SEMICONDUCTOR : to Engineer 0.18 micron Automotive Process Technology with ABOV, UNIST and SNU 4 Traders, 3 weeks ago MAGNACHIP SEMICONDUCTOR : MX to Develop 0.18 micron Automotive Process Technology with ABOV, UNIST and SNU 4 Traders, 3 weeks ago
Graphene paves the way for world's thinnest light bulb
Scientists from Columbia Engineering, Seoul National University (SNU), and Korea Research Institute of Standards and Science (KRISS) have demonstrated - for the first time - an on-chip visible light source using graphene as a filament. Page 1 of 3 ...Analog DesignLine Europe, 1 month ago Graphene enables tiny bulb on a chip Capacitor Industry, 1 month ago Graphene becomes incandescent light source for use in integrated photonic circuits OptoIQ, 1 month ago Graphene Used for World's Thinnest Light Bulb Azonano, 1 month ago
PST bekymret over IS-sympatisører i Sør-Trøndelag
Politiet og Trondheim kommune jobber for å kartlegge og snu IS-sympati i muslimske miljøer. Bare i første halvår har Politiets sikkerhetstjeneste (PST) hatt minstNigerianHerald.com, 3 weeks ago
Retirement of Dr. J. Michael Crabtree Announced
Dr. J. Michael Crabtree, Associate Vice President for University Advancement at Southern Nazarene University (SNU), officially retired on June 30, 2015. Dr. Crabtree received his B. Music Ed and M.A. in Language Arts from Southern Nazarene ...Noodls, 4 weeks ago
Realtime News
on your WebpageAdd Widget >Get your members hooked!


text:
45 points
More About Points »
Stellaraudi Tt
Baton Rouge, LA
Recent Activity
Question Asked:
Trying to figure out what the general problems of a 2004 Audi TT would be and it would be helpful for information like, "in general transmission goes out after so many mile, or anythign else you all know. Thanks!
Answer Ranks
This week's top 10
|1 stevieray1
|6 yaclo
|2 pushrod
|7 BobbyRobby
|3 globalhelper
|8 ziptie12
|4 csubak30
|9 jeffreyneal
|5 Mingo Automotive
|10 Chevyman4ever


text:
Welcome my friends! Today we bring you Angill. The sexy French bombshell that tore our 2 guys up! They met her at the pier and she got really friendly. She was on vacation and looking for a couple of tour guides. So they agreed to show her around after she came to their place. From then on it was a wrap! They took her back to their place for a little drink and things got spicier and spicier. Soon after, after a couple of photos, our guy started popping her titties out and getting Angill horny as hell! Knowing these guys they meant business! They tagged teamed and tore Angills ass up! Entering every oriface capable! Truly a fucking epic sex scene. Check It Out!! EnJoY!
"Dual Pump"
Teena Lipoldino
"Dual Licking"
Gina Gerson
"Simply Stunning"
Anita Berlusconi
"Chelsey Takes Two"
Chelsey Lanette
"Fit And Fine"
April Blue
"Summer Of Love"
"Licking Party"
Lucy Heart
"Deep Drilling"
Gina Gerson
"Date Night"
Alexis Brill


text:
Clinton Family YMCA(OLD) by Daxko Mobile Apps Clinton Family YMCA Search exercise schedules, get new program information, see sports field closings and more! The ap … 100+ downloads, Rating 4.00 (1) Free
LCNTUR VIAGENS by CNTAPPS A LCNTUR oferece aos clientes diversos serviços como: Passagens aéreas nacionais e internacionais; Hotéis nacionais e i … 10+ downloads, Rating 0.00 (0) $2.05
Autostarts by Michael Elsdörfer The Original Autostarts Manager. Keep control over your phone: See what applications do behind your back. I will show … 50,000+ downloads, Rating 4.33 (2534) Free
Fruit Blaster by Marco Franke The objective of the game is to prevent that any fruit reach the bottom. Unfortunately, the fruit move to the bottom ov … 500+ downloads, Rating 3.00 (1) Free
Block 2048 by REP COM.Inc This is a new pazzle game, which looks like "2048" and looks like "Tetris" too. How to play: - Swipe the screen horizon … 500+ downloads, Rating 3.88 (16) Free
Saint Petersburg (Metro 24) by Dmitriy V. Lozenko ★ BEFORE USING THIS MAP YOU NEED INSTALL APPLICATION CALLED "METRO 24" ★★★ Metro map of Saint Petersburg (Russia) for a … 100,000+ downloads, Rating 3.91 (1118) Free
EXO Puzzle Game by L nug Labs Free EXO Puzzle Game (Unofficial) to play. Fun for all EXO fans! Puzzles range from (easy) 8 to (hard) 24 pieces with a … 10,000+ downloads, Rating 4.40 (792) $1.03
beHEXed by BBG Entertainment Get hexed with this tangram style puzzle game! beHEXed will inspire you! You have to solve many different puzzles. Sol … 500+ downloads, Rating 3.91 (22) Free
Milaan by Sai Springtech This Mobile app called MILAAN is dedicated to all the people of our country who have gone missing and are never found. … 100+ downloads, Rating 5.00 (4) Free
Rapidly -launch installed apps by Siris Technology Formerly Fastly Search and launch local apps quickly A better alternative to AppDialer Use your native keyboard to searc … 1,000+ downloads, Rating 4.04 (55) Free
Print Hammermill Updated by Aftograf LLC Free Mobile Print App brought to you by Hammermill® Papers. No in-app purchases necessary. Print directly from your pho … 100,000+ downloads, Rating 4.60 (4233) Free
Track AliExpress in Lebanon by GEORGES EL-HAJAL Track AliExpress in Lebanon is an application that will keep you updated on the status of the package delivered by Post … 10,000+ downloads, Rating 4.38 (117) Free
Personal Finance by Bishinews Highlighted by Google, the Personal Finance is your personal finance hub with the following great features: • Stock wit … 100,000+ downloads, Rating 4.30 (1583) Free
Pandora® Radio by Pandora Great music discovery is effortless and free with Pandora. Just start with the name of one of your favorite artists, son … 100,000,000+ downloads, Rating 4.43 (2109759) $0.99
Aloha English - ESL study game by TopicMatch Aloha English is a learning tool for memorizing knowledge about Hawai'i and our planet's environment through playing a u … 1+ downloads, Rating 0.00 (0)


text:
(click to save the high quality version)
in the U.S.
since 1880
Gender: Boy. Ranked #3859 most popular
What does the name "Zaiden" mean?
Zaiden (American): Increasing, Surplus
The name "Zaiden" is of American origin and it means "Increasing, Surplus". It's a name commonly given to both boys and girls.
Z is for zany, the funny side of you!
A is for acquaintance, the many friends you know.
I is for impress, for impress you will.
D is for dignity, no one disputes this trait!
E is for enrich, a quality you share.
N is for natural, the genuine side of you.
Your name in reverse order is "Nediaz". A random rearrangement of the letters in your name (anagram) will give "Zeinad". How do you pronounce that?
Now try the names of everyone you know including friends, cousins, neighbors, classmates, co-workers or your pets. Even your favorite anime, TV or movie characters! See what their names mean. Remember, this is purely just for fun.
How popular is the name "Zaiden" in the U.S.?
Want to know about the populiarty of Zaiden? From 1880 to 2014, the Social Security Administration has recorded 4,490 babies born with the name Zaiden in the United States. That's more than enough Zaidens to occupy the territory of Saint Helena, Ascension and Tristan da Cunha (United Kingdom) with an estimated population of 4,000 (as of July 1, 2012). The name first appeared in the year 2000 when it was given to 5 new born babies. The highest recorded use of the name "Zaiden" was in 2013 with a total of 959 babies.
According to the 2009 U.S. Social Security Administration data, the name "Zaiden" is not a popular baby boy's name in Texas. Imagine that, only 39 babies in Texas have the same name as you in 2009. Across the entire United States a total of only 297 babies also bear the same first name during the same year.
Where is the name Zaiden popular?
The map shows the relative popularity of the name Zaiden in each of the states since 1950. Can you guess a name that was popular in the new england region? Search for the name to check your answer!
Past life for Zaiden born Dec 23, 1923
I do not know how you feel about it, but you were a female in your last earthly incarnation. You were born somewhere around the territory of Northern Canada approximately on 1200. Your profession was seaman, cook, and carpenter.
Psychologically, you had a Bohemian personality - mysterious, highly gifted, capable of understanding ancient books. Magical abilities, could be a servant of dark forces. The timid, lonely and self-confident people are everywhere, and your problem - to overcome these tendencies in yourself and then to help other people.
Here's something for you to ponder on...
What Does My Name Mean? - Have you wondered at one time or another what does my name mean? Knowing the meaning of your name can make you feel more amenable to your name than before.


text:
Property is in demand due to reduced inventory, as there are more potential buyers than sellers. Bidding wars with other buyers are possible, and listings begin to sell at greater than the asking price.
Rental property is in high demand and availability is low. Rent prices have increased by 2% over the past 3 months. This is 32% lower than the state average of $1,789 and 83% lower than the country average of $2,475.
The average home price in 70820 is $229,419, which is 23.8% higher than the average sold price in 70820 ($185,367) . The average home price per square foot in 70820 is $111 and about 3% of all homes in 70820 sold in the last 6 months. For 70820 home values, real estate prices, and city market trends, research the 5,041 property records or search our 165 recently sold or 151 homes for sale listings. The listings and properties in 70820 are only a part of the 1,482,183 properties and 19,331 homes for sale in Louisiana. Because of this, the average home price and average home value of 70820 also influence the average home price $227,135 and average sale price $192,670 of Louisiana. Listing counts, 70820 home prices and home values in 70820 are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.


text:
|By John Ryan
Article Rating:
|August 19, 2010 01:15 PM EDT
According to Intel, the reasons this makes sense are:
- Acquisition enables a combination of security software and hardware from one company to ultimately better protect consumers, corporations and governments as billions of devices - and the server and cloud networks that manage them - go online.
- Intel elevates focus on security on par with energy-efficient performance and connectivity. The acquisition augments Intel's mobile wireless strategy, helping to better assure customer and consumer security concerns as these billions of devices connect.
- Intel has made a number of software-related acquisitions of leaders in their respective industries that also rely on great silicon, including Wind River, Havok and now McAfee.
The release itself -
SANTA CLARA, Calif., Aug. 19, 2010 – Intel Corporation has entered into a definitive agreement to acquire McAfee, Inc., through the purchase of all of the company's common stock at $48 per share in cash, for approximately $7.68 billion. Both boards of directors have unanimously approved the deal, which is expected to close after McAfee shareholder approval, regulatory clearances and other customary conditions specified in the agreement.
The acquisition reflects that security is now a fundamental component of online computing. Today's security approach does not fully address the billions of new Internet-ready devices connecting, including mobile and wireless devices, TVs, cars, medical devices and ATM machines as well as the accompanying surge in cyber threats. Providing protection to a diverse online world requires a fundamentally new approach involving software, hardware and services.
Inside Intel, the company has elevated the priority of security to be on par with its strategic focus areas in energy-efficient performance and Internet connectivity.
McAfee, which has enjoyed double-digit, year-over-year growth and nearly 80 percent gross margins last year, will become a wholly-owned subsidiary of Intel, reporting into Intel's Software and Services Group. The group is managed by Renée James, Intel senior vice president, and general manager of the group.
"With the rapid expansion of growth across a vast array of Internet-connected devices, more and more of the elements of our lives have moved online," said Paul Otellini, Intel president and CEO. "In the past, energy-efficient performance and connectivity have defined computing requirements. Looking forward, security will join those as a third pillar of what people demand from all computing experiences.
"The addition of McAfee products and technologies into the Intel computing portfolio brings us incredibly talented people with a track record of delivering security innovations, products and services that the industry and consumers trust to make connecting to the Internet safer and more secure," Otellini added.
"Hardware-enhanced security will lead to breakthroughs in effectively countering the increasingly sophisticated threats of today and tomorrow," said James. "This acquisition is consistent with our software and services strategy to deliver an outstanding computing experience in fast-growing business areas, especially around the move to wireless mobility."
"McAfee is the next step in this strategy, and the right security partner for us," she added. "Our current work together has impressive prospects, and we look forward to introducing a product from our strategic partnership next year."
"The cyber threat landscape has changed dramatically over the past few years, with millions of new threats appearing every month," said Dave DeWalt, president and CEO of McAfee. "We believe this acquisition will result in our ability to deliver a safer, more secure and trusted Internet-enabled device experience."
McAfee, based in Santa Clara and founded in 1987, is the world's largest dedicated security technology company with approximately $2 billion in revenue in 2009. With approximately 6,100 employees, McAfee's products and technologies deliver secure solutions and services to consumers, enterprises and governments around the world and include a strong sales force that works with a variety of customers.
The company has a suite of software-related security solutions, including end-point and networking products and services that are focused on helping to ensure Internet-connected devices and networks are protected from malicious content, phony requests and unsecured transactions and communications. Among others, products include McAfee Total Protection™, McAfee Antivirus, McAfee Internet Security, McAfee Firewall, McAfee IPS as well as an expanding line of products targeting mobile devices such as smartphones.
Intel has made a series of recent and successful software acquisitions to pursue a deliberate strategy focused on leading companies in their industry delivering software that takes advantage of silicon. These include gaming, visual computing, embedded device and machine software and now security.
Home to two of the most innovative labs and research in the high-tech industry, Intel and McAfee will also jointly explore future product concepts to further strengthen security in the cloud network and myriad of computers and devices people use in their everyday lives.
On a GAAP basis, Intel expects the combination to be slightly dilutive to earnings in the first year of operations and approximately flat in the second year. On a non-GAAP basis, excluding a one-time write down of deferred revenue when the transaction closes and amortization of acquired intangibles, Intel expects the combination to be slightly accretive in the first year and improve beyond that.
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
Aug. 3, 2015 06:45 PM EDT Reads: 541
For IoT to grow as quickly as analyst firms' project, a lot is going to fall on developers to quickly bring applications to market. But the lack of a standard development platform threatens to slow growth and make application development more time consuming and costly, much like we've seen in the mobile space. In his session at @ThingsExpo, Mike Weiner, Product Manager of the Omega DevCloud with KORE Telematics Inc., discussed the evolving requirements for developers as IoT matures and conducted a live demonstration of how quickly application development can happen when the need to comply wit...
Aug. 2, 2015 11:15 AM EDT Reads: 371
The Internet of Everything (IoE) brings together people, process, data and things to make networked connections more relevant and valuable than ever before – transforming information into knowledge and knowledge into wisdom. IoE creates new capabilities, richer experiences, and unprecedented opportunities to improve business and government operations, decision making and mission support capabilities.
Aug. 1, 2015 10:00 AM EDT Reads: 347
Explosive growth in connected devices. Enormous amounts of data for collection and analysis. Critical use of data for split-second decision making and actionable information. All three are factors in making the Internet of Things a reality. Yet, any one factor would have an IT organization pondering its infrastructure strategy. How should your organization enhance its IT framework to enable an Internet of Things implementation? In his session at @ThingsExpo, James Kirkland, Red Hat's Chief Architect for the Internet of Things and Intelligent Systems, described how to revolutionize your archit...
Jul. 30, 2015 07:30 PM EDT Reads: 1,432
MuleSoft has announced the findings of its 2015 Connectivity Benchmark Report on the adoption and business impact of APIs. The findings suggest traditional businesses are quickly evolving into "composable enterprises" built out of hundreds of connected software services, applications and devices. Most are embracing the Internet of Things (IoT) and microservices technologies like Docker. A majority are integrating wearables, like smart watches, and more than half plan to generate revenue with APIs within the next year.
Jul. 30, 2015 02:30 PM EDT Reads: 151
Growth hacking is common for startups to make unheard-of progress in building their business. Career Hacks can help Geek Girls and those who support them (yes, that's you too, Dad!) to excel in this typically male-dominated world. Get ready to learn the facts: Is there a bias against women in the tech / developer communities? Why are women 50% of the workforce, but hold only 24% of the STEM or IT positions? Some beginnings of what to do about it! In her Opening Keynote at 16th Cloud Expo, Sandy Carter, IBM General Manager Cloud Ecosystem and Developers, and a Social Business Evangelist, d...
Jul. 30, 2015 12:00 PM EDT Reads: 2,092
In his keynote at 16th Cloud Expo, Rodney Rogers, CEO of Virtustream, discussed the evolution of the company from inception to its recent acquisition by EMC – including personal insights, lessons learned (and some WTF moments) along the way. Learn how Virtustream's unique approach of combining the economics and elasticity of the consumer cloud model with proper performance, application automation and security into a platform became a breakout success with enterprise customers and a natural fit for the EMC Federation.
Jul. 30, 2015 09:00 AM EDT Reads: 2,182
The Internet of Things is not only adding billions of sensors and billions of terabytes to the Internet. It is also forcing a fundamental change in the way we envision Information Technology. For the first time, more data is being created by devices at the edge of the Internet rather than from centralized systems. What does this mean for today's IT professional? In this Power Panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists addressed this very serious issue of profound change in the industry.
Jul. 29, 2015 03:00 PM EDT Reads: 1,305
Discussions about cloud computing are evolving into discussions about enterprise IT in general. As enterprises increasingly migrate toward their own unique clouds, new issues such as the use of containers and microservices emerge to keep things interesting. In this Power Panel at 16th Cloud Expo, moderated by Conference Chair Roger Strukhoff, panelists addressed the state of cloud computing today, and what enterprise IT professionals need to know about how the latest topics and trends affect their organization.
Jul. 29, 2015 02:00 PM EDT Reads: 1,215
It is one thing to build single industrial IoT applications, but what will it take to build the Smart Cities and truly society-changing applications of the future? The technology won't be the problem, it will be the number of parties that need to work together and be aligned in their motivation to succeed. In his session at @ThingsExpo, Jason Mondanaro, Director, Product Management at Metanga, discussed how you can plan to cooperate, partner, and form lasting all-star teams to change the world and it starts with business models and monetization strategies.
Jul. 28, 2015 04:30 PM EDT Reads: 1,780
Converging digital disruptions is creating a major sea change - Cisco calls this the Internet of Everything (IoE). IoE is the network connection of People, Process, Data and Things, fueled by Cloud, Mobile, Social, Analytics and Security, and it represents a $19Trillion value-at-stake over the next 10 years. In her keynote at @ThingsExpo, Manjula Talreja, VP of Cisco Consulting Services, discussed IoE and the enormous opportunities it provides to public and private firms alike. She will share what businesses must do to thrive in the IoE economy, citing examples from several industry sectors.
Jul. 28, 2015 11:00 AM EDT Reads: 2,055
There will be 150 billion connected devices by 2020. New digital businesses have already disrupted value chains across every industry. APIs are at the center of the digital business. You need to understand what assets you have that can be exposed digitally, what their digital value chain is, and how to create an effective business model around that value chain to compete in this economy. No enterprise can be complacent and not engage in the digital economy. Learn how to be the disruptor and not the disruptee.
Jul. 27, 2015 10:00 AM EDT Reads: 2,052
Akana has released Envision, an enhanced API analytics platform that helps enterprises mine critical insights across their digital eco-systems, understand their customers and partners and offer value-added personalized services. "In today's digital economy, data-driven insights are proving to be a key differentiator for businesses. Understanding the data that is being tunneled through their APIs and how it can be used to optimize their business and operations is of paramount importance," said Alistair Farquharson, CTO of Akana.
Jul. 27, 2015 09:00 AM EDT Reads: 338
Business as usual for IT is evolving into a "Make or Buy" decision on a service-by-service conversation with input from the LOBs. How does your organization move forward with cloud? In his general session at 16th Cloud Expo, Paul Maravei, Regional Sales Manager, Hybrid Cloud and Managed Services at Cisco, discusses how Cisco and its partners offer a market-leading portfolio and ecosystem of cloud infrastructure and application services that allow you to uniquely and securely combine cloud business applications and services across multiple cloud delivery models.
Jul. 27, 2015 08:00 AM EDT Reads: 1,914
The enterprise market will drive IoT device adoption over the next five years. In his session at @ThingsExpo, John Greenough, an analyst at BI Intelligence, division of Business Insider, analyzed how companies will adopt IoT products and the associated cost of adopting those products. John Greenough is the lead analyst covering the Internet of Things for BI Intelligence- Business Insider's paid research service. Numerous IoT companies have cited his analysis of the IoT. Prior to joining BI Intelligence, he worked analyzing bank technology for Corporate Insight and The Clearing House Payment...
Jul. 26, 2015 09:00 PM EDT Reads: 1,595
"Optimal Design is a technology integration and product development firm that specializes in connecting devices to the cloud," stated Joe Wascow, Co-Founder & CMO of Optimal Design, in this SYS-CON.tv interview at @ThingsExpo, held June 9-11, 2015, at the Javits Center in New York City.
Jul. 25, 2015 02:00 PM EDT Reads: 406
SYS-CON Events announced today that CommVault has been named "Bronze Sponsor" of SYS-CON's 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. A singular vision – a belief in a better way to address current and future data management needs – guides CommVault in the development of Singular Information Management® solutions for high-performance data protection, universal availability and simplified management of data on complex storage networks. CommVault's exclusive single-platform architecture gives companies unp...
Jul. 25, 2015 01:00 PM EDT Reads: 1,980
Electric Cloud and Arynga have announced a product integration partnership that will bring Continuous Delivery solutions to the automotive Internet-of-Things (IoT) market. The joint solution will help automotive manufacturers, OEMs and system integrators adopt DevOps automation and Continuous Delivery practices that reduce software build and release cycle times within the complex and specific parameters of embedded and IoT software systems.
Jul. 25, 2015 12:15 PM EDT Reads: 490
"ciqada is a combined platform of hardware modules and server products that lets people take their existing devices or new devices and lets them be accessible over the Internet for their users," noted Geoff Engelstein of ciqada, a division of Mars International, in this SYS-CON.tv interview at @ThingsExpo, held June 9-11, 2015, at the Javits Center in New York City.
Jul. 25, 2015 12:00 PM EDT Reads: 1,563
Internet of Things is moving from being a hype to a reality. Experts estimate that internet connected cars will grow to 152 million, while over 100 million internet connected wireless light bulbs and lamps will be operational by 2020. These and many other intriguing statistics highlight the importance of Internet powered devices and how market penetration is going to multiply many times over in the next few years.
Jul. 25, 2015 09:00 AM EDT Reads: 1,509


text:
Scott Baldwin
- BiographyThis white actor has produced 1 video scene, having starred on camera for the first time in Getting In Tight around June 1996. Some other actors who have co-starred alongside Scott are Cort Stevens, Tanner Reeves, and Coy Dekker. Content starring Scott has been watched 4,494 times, with over 0.1 GB worth of exciting porn having been transferred during the previous twelve months. His most often performed actions include Handjobs, Anal Licking, Cum on Ass, Blowjobs, and Anal Sex.
- Views4,494
- Favorted0 times
- Rating
Similar Stars
Scenes (1)
Sort By: Rating | Views | Newest
Get Your Gay Access Now!
Excellent Hot Gay...
Getting In Tight June 05 1996


text:
Hotel White House
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Restaurant
- Business Services
- Fitness/Health center
Travelers also recommend:
TripAdvisor Reviews Hotel White House Pushkar
Travel Blogs from Pushkar
... for a beautiful sunset and then had dinner on the waters edge next to all the tourists dancing to some live reggae music. Dinner was slightly delayed as the power cut out for a while (very common around here) but we were entertained by a gorgeous puppy who came and slept at my feet. Normally we wouldn't touch any of the dogs as you can tell they're quite flea/disease ridden but this little guy looked pretty clean. After dinner I felt so bad leaving ...
Camping beside the lake - don't mind if we do!
... the locals both on the platform and in the trains carriages!
Jumping on the back of pick up trucks we are whisked away further into the farming areas of Rajasthan to a lake side venue complete with our tents that have ensuites and double beds! We happily spend the afternoon chilling out playing card games, sipping gin and tonics and watching the sunset whilst reflecting upon ...
Walking cash machines
... groans from us about this we are learning to be sharper witted, without losing trust in humanity, and each experience we have gives us a concrete experience to draw from in future, wisdom is a gift in itself.
So, bye for now to the crazy street bazarr, beeping horns, temples galore and smuggled booze, tomorrow morning we head off to our next destination, and hopefully a whole new bunch of experiences to get involved in, discuss and learn lessons from.
The next stop will ...
Pushkar, India
... Western tourists alike), a few isolated scamsters trying to forcibly give you flowers to 'make an offering' and get you to separate from a few too many rupees, and a few more 'come look in my shop's', which we had found refreshingly almost absent in the rest of India. Still, there was a lot of genuine 'namaste's' and hello's to more than make up for it. It was pretty quiet around the ghats (which given it was 46 deg in ...
A visit to the Indian countryside....
After an amazing few days in Jaipur I set off into rural areas to experience the real India as people have told me since I have been here 'the countryside is where you will see real India'... Which is in fact very true. After a two hour drive in land cruisers through many rural villages we arrived in a village called Tordi Sagar. Our accommodation was a homestay which was awesome very good food, amazing local Indian people and ...


text:
U.S. Secretary of State John Kerry reacts as he presses a button to raise his lectern before his remarks at a groundbreaking ceremony for the U.S. Diplomacy Center at the State Department in Washington September 3, 2014. REUTERS/Jonathan Ernst
Kerry voices US concern over India-Pakistan tensions
Kerry still hospitalized 10 days after breaking femur
Your feedback is important to us!
We invite all our readers to share with us their views and comments about this article.
Disclaimer: Comments submitted by third parties on this site are the sole responsibility of the individual(s) whose content is submitted. The Daily Star accepts no responsibility for the content of comment(s), including, without limitation, any error, omission or inaccuracy therein. Please note that your email address will NOT appear on the site.
Alert: If you are facing problems with posting comments, please note that you must verify your email with Disqus prior to posting a comment. follow this link to make sure your account meets the requirements. (http://bit.ly/vDisqus)
For the first time since the latest devastating Israeli assault on Gaza that left over 2,100 Palestinians dead, U.S. Secretary of State John Kerry met Wednesday with Palestinian negotiators.The meeting followed a phone call between Kerry and Israeli Prime Minister Benjamin Netanyahu in which the former expressed his concerns over Israeli plans to take some 988 acres of land from the West Bank for settlement building – the largest land grab since the 1980s. Although Kerry has shown genuine concern for the peace process, he is perhaps verging on delusional if he thinks his talks with Saeb Erekat and co. were constructive.
Kerry voices US concern over India-Pakistan tensions
Kerry still hospitalized 10 days after breaking femur
The United States will deliver eight F-16 Block 52 aircraft to Egypt within the next two days, the U.S. embassy in...
Russian President Vladimir Putin told Israeli Prime Minister Benjamin Netanyahu that the deal on Iran's nuclear...
China's Defense Ministry Thursday accused the United States of "militarizing" the South China Sea by staging patrols...
A senior military officer has said Israel could attack militants affiliated to ISIS in neighboring Egypt's Sinai...
The U.S. State Department said Wednesday it was "deeply concerned" about an Israeli government decision to build 300...


text:
- About Us
- Nanotechnology
- News
- Columns
- Products
- Directories
- Career Center
- Nano-Social Network
- Nano Consulting
- My Account
Home > News > Building with RNA; Nanotech X Prize; Closing remarks
October 28th, 2005
Building with RNA; Nanotech X Prize; Closing remarks
Christine Peterson: Last talk: Luc Jaeger of UCSB explaining "Sculpting Bio-materials by Programmable Assembly of RNA". He has been building super-molecular RNA assemblies.
Before the closing remarks, we have a short announcement about the "X Prize for Nanotech" challenge grant from Marshall Burns. There will be a Nanotech X Prize Summit in early 2006. Current need is for sponsorship — first sponsor has made a challenge grant, issued by Mark Sims of Nanorex. Mark is referring to Engines of Creation as inspiration, and describing the history of the first $10 million X Prize, and saying that we need that excitement for nanotech.
(Ed.'s note: read more notes on the Foresight Conf. in the nanodot blog.)
|Related News Press
Engineering a better 'Do: Purdue researchers are learning how August 4th, 2015
Proving nanoparticles in sunscreen products August 4th, 2015
Global Carbon Nanotubes Industry 2015: Acute Market Reports August 4th, 2015
Nanoparticles Give Antibacterial Properties to Machine-Woven Carpets August 4th, 2015
|The latest news from around the world, FREE
|Premium Products
Only the news you want to read!
Learn More
University Technology Transfer & Patents
Learn More
Full-service, expert consulting
Learn More


text:
Category Archives: Uncategorized
Coordinating against malaria
In December 1974, the last cases of smallpox in its deadliest form were confined to a Bangladesh slum. Public health workers were preparing the scourge's coup de grâce, but were horrified when government bulldozers arrived, scattering 50,000 people across the countryside.
The ill-timed demolition of the slum spread the disease throughout the country, sparking outbreaks in several locations and extending the suffering and death from smallpox for another 10 months. The chapter illustrates the difficulty of ridding the world of a human disease, even one down to its last few cases, and how important it is that eradication efforts include whole societies.
A group of scientists, government officials, nonprofit leaders, malaria-control program directors, and others gathered at Harvard Business School last week sought to draw lessons from past eradication efforts as they embarked on a weeklong leadership program focused on eradicating another age-old scourge: malaria.
Though the program's 56 participants have been involved in different aspects of the fight against malaria for years, Dyann Wirth, the Richard Pearson Strong Professor of Infectious Disease, chair of the Harvard T.H. Chan School of Public Health's Department of Immunology and Infectious Diseases, and director of the Harvard Malaria Initiative, said that shifting officials' focus from control and treatment of the disease to eradication requires shifting strategies as well.
"We want to give them the overview of the problem of malaria, all the way from the genes to the globe," Wirth said. "Many of them work [on malaria]… and although most in the room probably have had this material at one point, they haven't thought about it in this lens of elimination/eradication, which is quite different from treating symptomatic cases or preventing symptomatic cases."
Smallpox stands as the only human disease successfully stamped out, so the intensive leadership program kicked off with a talk by Myron Levine, a University of Maryland professor who was a World Health Organization (WHO) consultant in Bangladesh during the final days battling smallpox's most virulent strain, variola major. It would take another two years to eradicate a less deadly strain, variola minor, though there were laboratory-related cases in 1978.
Global anti-malaria efforts have made significant progress, Wirth said, with cases down 30 percent and deaths down 50 percent over the last 15 years. Even with that decline, however, malaria is far from on the ropes. In 2013 alone, there were an estimated 198,000,000 cases and 584,000 deaths, according to the WHO.
The leadership development program, called "Science of Eradication: Malaria 2015," provided a broad overview, including the disease's basic biology, challenges facing vaccine development, social determinants of transmission, economic advantages to eradication, the importance of communication, and ways to integrate eradication into existing control efforts.
The program is a partnership of organizations including Harvard, the Barcelona Institute for Global Health, and the Swiss Tropical and Public Health Institute, with funding from several other organizations.
Malaria may not become the second human disease to be wiped out. That's because efforts targeting two other ailments, polio and guinea worm disease (which is caused by a tropical parasite), are on the verge of success, with the number of cases reduced to just a handful.
Elizabeth Juma, a research scientist with the Kenya Medical Research Institute, said malaria remains a major health problem there and is the biggest cause of death for children under 5. It's widespread in the nation's agricultural areas, making it an issue in agricultural production. Juma said she decided to attend the session to understand how the goal of elimination in Kenya would affect ongoing control efforts.
"The global goals have changed," Juma said. "We now have to think of malaria elimination. [I decided to attend] to just find out … what should we do about a country such as ours, where this has been attempted in the past, and how best can we think about the endgame, which is elimination."
Ndukwe Ukoha, a malaria specialist for the Health and Strategy Delivery Foundation, a Nigerian nonprofit that provides technical assistance to the government on health issues, said malaria is also a major public health concern in Nigeria. As Africa's most populous country, with 184 million people, efforts to reduce malaria there will have an impact on the global disease burden, Ukoha said.
"We are presently controlling malaria in Nigeria, [but] we also need to look at new ways of doing things, new ways of developing more effective tools, because … presently there are issues around resistance and also health system issues," Ukoha said. "So this kind of forum provides an avenue to talk about these, and even learn from countries where they have successfully achieved high success."
By Alvin Powell, Harvard Staff Writer
To see original article click here
New tool identifies novel compound targeting causes of type 2 diabetes
A new drug screening technology developed at the Harvard T.H. Chan School of Public Health has identified a new potential anti-diabetes compound—and a powerful way to quickly test whether other molecules can have a positive effect on a critical molecular pathway believed to be central to diseases ranging from diabetes to retinitis pigmentosa, cystic fibrosis, Huntington's disease, and Alzheimer's.
The study appears in the June 17, 2015 issue of Science Translational Medicine. (The animation at the top of the page depicts how dysfunction in the endoplasmic reticulum leads to diabetes.)
The compound, which the authors have called azoramide*, works by focusing on an organelle called the endoplasmic reticulum (ER). The ER is a tubular network within all cells where many key molecular building blocks of glucose metabolism, such as lipids and proteins, are synthesized. When someone is obese, the ER in metabolic tissues such as the liver, fat, and pancreas can no longer keep up with the demand for protein and lipid production. This results in ER stress which contributes to cellular dysfunction and the development of insulin resistance. Insulin resistance in turn makes it difficult for the body to process glucose —high blood sugar and type 2 diabetes result, as well as a cascade of other cellular malfunctions that can lead to heart and blood vessel damage.
"While we and others had previously discovered the central role that ER stress plays in diabetes and metabolic disease, efforts to translate that knowledge into clinically effective ways to improve ER function have had limited success so far," says the study's senior author, Gökhan S. Hotamisligil, chair of the Department of Genetics and Complex Diseases and the Sabri Ülker Center at Harvard T.H. Chan School of Public Health. Lead authors were current and former Hotamisligil lab members Suneng Fu, Abdullah Yalcin, and Grace Yankun Lee.
The study describes the development of two complementary assays that allow scientists to directly monitor ER function in live cellular systems in culture in the lab. This screening system enables measurement of the amount of chaperones, molecules that patrol and promote ER function, as well as the capacity of the ER to properly fold proteins into their three-dimensional shapes. Using this technique, they showed that azoramide uniquely improved both of these aspects of ER function. In further mechanistic work, they also demonstrated that azoramide could protect cells from death and dysfunction in multiple models of ER stress.
The researchers next tested whether azoramide would be effective in mouse models of obesity and type 2 diabetes, and determined that it greatly improved blood glucose levels by improving both the function of insulin-producing beta cells and increasing the ability of peripheral tissues to sense insulin. The next phase of this research would be to test this compound, or others that work in a similar manner, in human clinical trials.
In another aspect of the paper's research the scientists determined that azoramide could potentially protect retinal cells from the genetic mutation that leads to ER stress and ultimately vision loss in one type of the disease retinitis pigmentosa.
"These results show the broad potential for azoramide or drugs with similar functions targeted at the endoplasmic reticulum," said Hotamisligil. "ER dysfunction is implicated in many other disease processes such as cystic fibrosis, Huntington's disease, and Alzheimer's—which makes this novel screening strategy an exciting new tool that can be applied by multiple labs to discover new drug candidates for diseases that are linked to ER stress."
Other Harvard Chan School authors included Ping Li, Jason Fan, Ana Paula Arruda, Benedicte M. Pers, Mustafa Yilmaz, and Kosei Eguchi.
*Azoramide is an existing compound , the complete name of which is N-{2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]ethyl} butanamide.
This work was supported in part by a grant from the Juvenile Diabetes Research Foundation (17-2012-346) to Hotamisligil.
"Phenotypic assays identify azoramide, a small molecule modulator of the unfolded protein response with anti-diabetic activity," Suneng Fu, Abdullah Yalcin, Grace Y. Lee, Ping Li, Jason Fan, Ana Paula Arruda, Benedicte M. Pers, Mustafa Yilmaz, Kosei Eguchi, Gökhan S. Hotamisligil, Science Translational Medicine, June 17, 2015 DOI: 10.1126/scitranslmed.aaa9134
To see the original article click here
animation: Craig LaPlante
Chih-Hao Lee Promoted to Tenured Professor
Dr. Lee received the BS degree in chemical engineering at National Tsing-Hua University, Taiwan, in 1989. After serving in the military, Dr. Lee went on to receive a PhD in Pharmacology from the University of Minnesota, Minneapolis in 1999. As a doctoral student, in 1998, Dr. Lee was presented with the Bacaner Research Award for excellence in creative research. Upon completion of his degree, he spent five years in postdoctoral training in Molecular Physiology at the Salk Institute for Biological Studies. In 2004 he joined the Harvard School of Public Health in the Department of Genetics and Complex Diseases as Assistant Professor. Dr. Lee received the William F. Milton Fund Award in 2005 and the Scientist Development Grant awarded by the American Heart Association in 2006. In 2010, Dr. Lee was promoted to Associate Professor of Genetics and Complex Diseases at the School. He was honored with the Mentoring Award by the graduating class of 2011. In 2012, Dr. Lee received the Armen H. Tashjian Jr. Award for Excellence in Endocrine Research.
On behalf of the School and the faculty, I congratulate Dr. Lee on his promotion and wish him continued success in his career at the Harvard T.H. Chan School of Public Health.
Best wishes,
David Hunter
Dean for Academic Affairs
A bench scientist with a passion for the environment
On a Friday afternoon in May, Peter Wagner was about to give his dissertation defense. Quan Lu, associate professor of environmental genetics and pathophysiology—introducing Peter before a group of about 50 of his fellow students, faculty, friends, and family—flashed an on-screen photo of Peter as a young boy with a snake draped around his neck. Then came photos of Peter outdoors—in mountains, near lakes, under blue skies.
The pictures showcased Peter's deep interest in the environment, which—along with his background in bench science—led him in 2010 to Lu's lab at Harvard T.H. Chan School of Public Health, where he studied the brain's molecular response to lead exposure. This May, Peter will graduate with a PhD in biological sciences in public health.
"I consider Peter the ideal student. He's smart, hardworking, and passionate about what he does," said Lu.
Seminal moment
In 8th grade, as a reporter for his middle school newspaper at the International School of Brussels, in Belgium, Peter interviewed Jane Goodall—a world expert on chimpanzees and an ardent conservationist—who was visiting the school. "It was a magical and seminal moment in which the environment suddenly became very important to me," he said. When Peter's father, a U.S. diplomat, was transferred and the family moved to Germany, Peter found that his new school—the Berlin-Brandenburg International School—didn't have an environmental club, so he started one himself.
Peter went on to study environmental biology at Columbia University in New York. While there, he discovered a penchant for lab work while working on his senior thesis, on bacteria in soil that can change the chemical form of arsenic, in the lab of Brian Mailloux. After graduation he spent two years in Finland—where his mother is from and where he was born—as a research assistant in the lab of Leena Peltonen-Palotie, a world-renowned geneticist, at the Institute for Molecular Medicine Finland in Helsinki. He learned much about population genetics and analytical methods. But he was looking for a way to combine his environmental background from Columbia with the genomics he learned in Finland—and that led him to Harvard Chan School.
"The School is probably the only place in the world where you can unify laboratory environmental exposures and human population genetics," said Peter. He cited the value of being able to use data from the epidemiological studies managed by David Christiani, Elkan Blout Professor of Environmental Genetics, as well as the opportunity to participate in cutting-edge science in Lu's lab.
Looking at lead
At his dissertation defense, Peter outlined some of the well-known negative effects of lead on children's development, such as lower IQs, increases in ADHD, and increased antisocial or delinquent behavior. "Even low amounts of lead can cause these effects," Peter said. Although the danger of lead is well known, it remains an environmental problem. In the U.S., for example, although lead in paint was banned in 1978, and lead in gasoline was mostly phased out in the 1980s, there is still lead in the environment. In urban areas in particular, lead-based paint flakes off windows and gets into household dust. In Guiyu, China, a town with a large electronic waste recycling plant, children living nearby have significantly higher blood lead levels than those living in a neighboring town.
Peter has researched the impact of lead on the brain from various angles. In the lab, he has looked at the genomic impact of lead on human neural stem cells in the brain. He has also looked at epidemiological data from 465 mother-child pairs participating in the ELEMENT (Early Life Exposure in Mexico to Environmental Toxicants) cohort in Mexico City, where people are exposed to lead from smog and lead glazes on dishes. Data from that cohort included lead levels in the children's blood over time as well as information on their mental and psychomotor development.
Peter's research suggests that some people have a genetic variant that actually helps protect them against lead's harmful effects. This discovery, he said, "could help us better understand the body's innate defenses to lead, and perhaps we could target those defenses so as to improve children's outcomes when they're exposed to lead."
In the community—and beyond
During his time at Harvard Chan, Peter has been a coordinator for the Roxbury Prep Tutoring Program run by the School's Office of Diversity and Inclusion. Through the program, Harvard Chan students tutor students at Roxbury Prep Charter School, a middle school in nearby Mission Hill, in math and science. "Everybody gets a lot out of it," he said.
After graduation, Peter will work as a life sciences consultant at a small company in Boston. Now that he's preparing to graduate, he offers a scientist's perspective on the benefits of studying at the School. "Often times people think it's strange that we do so much basic science at the School of Public Health, but it's really a wonderful environment to do it in," he said. "Everybody here wants to try and fix some kind of large public health problem. It's so easy to get tunnel vision when you're in a science lab and working at the bench. Being at a School where you're looking at health problems from every angle imaginable really helps you keep a fresh perspective."
— Karen Feldscher
photo: Emily Cuccarese
To see original article click here
Tobias Walther chosen as HHMI Investigator
Congratulations to Tobias Walter, who was chosen from a group of 894 eligible applicants to be one of 26 newly-minted Howard Hughes Medical Institute (HHMI) Investigators! HHMI investigators will receive the flexible support necessary to move their research in creative new directions. The initiative represents an investment in basic biomedical research of $153 million over the next five years.
The scientists represent 19 institutions from across the United States. The new HHMI investigators – which include three current HHMI early career scientists — were selected for their individual scientific excellence.
HHMI will provide each investigator with his or her full salary, benefits, and a research budget over their initial five-year appointment. The Institute will also cover other expenses, including research space and the purchase of critical equipment. Their appointment may be renewed for additional five-year terms, each contingent on a successful scientific review.
HHMI encourages its investigators to push their research fields into new areas of inquiry. By employing scientists as HHMI investigators — rather than awarding them research grants — the Institute is guided by the principle of "people, not projects." HHMI investigators have the freedom to explore and, if necessary, to change direction in their research. Moreover, they have support to follow their ideas through to fruition — even if that process takes many years.
Why Public Health? Selasi Dankwa
In our series "Why Public Health?" we ask Harvard T.H. Chan School of Public Health students and alumni to talk about what drew them to the field. Selasi Dankwa, PhD '15, took an early interest in infectious diseases like malaria and cholera, a part of everyday life in her home country of Ghana. At Harvard Chan School, she studies the parasites that cause malaria infection. Now she envisions taking her skills and knowledge and returning to Ghana to "make a difference."
See the video here: Why Public Health? Selasi Dankwa
Malaria parasite's essential doorway into red blood cells illuminated
Boston, MA – Researchers at Harvard T. H. Chan School of Public Health and the Broad Institute have identified a protein on the surface of human red blood cells that serves as an essential entry point for invasion by the malaria parasite. The presence of this protein, called CD55, was found to be critical to the Plasmodium falciparum parasite's ability to attach itself to the red blood cell surface during invasion. This discovery opens up a promising new avenue for the development of therapies to treat and prevent malaria.
"Plasmodium falciparum malaria parasites have evolved several key-like molecules to enter into human red blood cells through different door-like host receptors. Hence, if one red blood cell door is blocked, the parasite finds another way to enter," said senior author Manoj Duraisingh, John LaPorte Given Professor of Immunology and Infectious Diseases at Harvard Chan. "We have now identified an essential host factor which when removed prevents all parasite strains from entering red blood cells."
The five-year study was carried out in collaboration with labs at Harvard Medical School and the Broad Institute. It appears online May 7, 2015 in Science.
Severe malaria is one of the leading causes of mortality among children globally. During infection, parasites invade and replicate within red blood cells. With resistance to malaria drugs increasing, researchers are desperate to find new ways to prevent and treat the disease.
Lead author Elizabeth Egan, research fellow in the Department of Immunology and Infectious Diseases at Harvard Chan and instructor in pediatrics at Boston Children's Hospital, and colleagues developed a new technique to tap into a relatively unexplored area — identifying characteristics of a host red blood cell that make it susceptible to the parasites. Red blood cells are difficult targets for such efforts as they lack a nucleus, which makes genetic manipulation impossible.
The researchers transformed stem cells into red blood cells, which allowed them to conduct a genetic screen for host determinants of P. falciparum infection. They found that malaria parasites failed to attach properly to the surface of red blood cells that lacked CD55. The protein was required for invasion in all tested strains of the parasite, including those developed in a laboratory as well as those isolated from patients, making it a primary candidate for intervention.
"The discovery of CD55 as an essential host factor for P. falciparum raises the intriguing possibility of host-directed therapeutics for malaria, as is used in HIV," said Egan. "CD55 also gives us a hook with which to search for new parasite proteins important for invasion, which could serve as vaccine targets."
This study was supported by a Gates Foundation Grand Challenges Exploration Award OPP1035276 (M.T.D.), National Institutes of Health (NIH) grant R01AI091787 (M.T.D.), a Pediatric Scientist Development Program Fellowship from the Eunice Kennedy Shriver National Institute of Child Health and Human Development K12-HD000850 (E.S.E), NIH grant K08 1K08AI103034-01A1 (E.S.E.), Boston Children's Hospital Faculty Development Award (E.S.E.), NIH grant K01DK098285 (J.A.P.), and the Cambridge Biomedical Research Center, UK (M.P.W. and L.V.N.).
"A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion," Elizabeth S. Egan, Rays H.Y. Jiang, Mischka A. Moechtar, Natasha S. Barteneva, Michael P. Weekes, Luis V. Nobre, Steven P. Gygi, Joao A. Paulo, Charles Frantzreb, Yoshihiko Tani, Junko Takahashi, Seishi Watanabe, Jonathan Goldberg, Aditya S. Paul, Carlo Brugnara, David E. Root, Roger C. Wiegand, John G. Doench, Manoj T. Duraisingh, Science, online May 7, 2015
Visit the Harvard Chan website for the latest news, press releases, and multimedia offerings.
For more information:
Todd Datz
World Malaria Day forum explores public-private partnerships
The global community has made gains in fighting malaria, but those advances are tenuous and multi-sector partnerships are needed to eradicate the disease. That was the consensus among experts in the field who gathered at a forum co-hosted by Harvard's Defeating Malaria initiative on April 24 to mark World Malaria Day. The event, Partnerships for Malaria Elimination: Lessons and Opportunities, focused on the need to build partnerships between governments, academic researchers, and the private sector.
According to the World Health Organization, there were an estimated 198 million malaria cases in 2013 and an estimated 584,000 deaths. In a video message to the audience at the Joseph B. Martin Conference Center, Ray Chambers, the United Nation's Secretary-General's Special Envoy for Malaria, said that progress has been made in fighting the disease: Since 2000, there has been a 58% decrease in child deaths from malaria in Africa. Chambers said more gains are on the horizon.
"Today 55 countries are on target to reduce malaria incidences by 75% by the end of this year, and 26 countries are on a clear path towards elimination," he said, adding that cooperation at multiple levels will make that possible. "Partnerships have helped drive innovation, improve measurement, and provide the management expertise that strengthens our work. They hold the key to new solutions and new technology."
Dyann Wirth, Richard Pearson Strong Professor of Infectious Diseases and Chair, Department of Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health, said that type of holistic approach has driven the work of the Defeating Malaria initiative since its inception in 2011.
"We brought together individuals from across the spectrum of the malaria world, and across Harvard, trying to understand the fundamental aspects of this disease from its biology and transmission, all the way through the social, behavioral, and policy [components] to develop tools to attack the problem."
Wirth moderated a panel that focused on the unique challenges of providing those tools and interventions in faith-based communities, where there can be tension between traditional healers and technologically focused medical personnel. Panelists discussed the efforts of the NetsforLife project, a partnership with the Episcopal Relief & Development organization, which has provided more than 22 million insecticide-treated mosquito nets across Africa.
Wirth said that the project is an effective convergence of a faith-based approach with a more business-oriented method, bringing a different approach to malaria control than organizations with a medical or health delivery background. Wirth pointed out that it is a strategy that relies on cooperation and takes into account the multiple factors beyond medical treatment that can affect malaria control efforts. She believes this community-based approach can help reduce the resistance to those new initiatives. "Education and knowledge backed up by evidence allows people to see and actually evaluate [interventions] for themselves."
In addition to implementation of malaria control measures, forum attendees also heard about various technological advances that could allow for more rapid diagnosis of the disease.
The Corporate Alliance for Malaria in Africa and GBCHealth co-sponsored the event.
Curtis Huttenhower wins top junior faculty award in bioinformatics
Curtis Huttenhower, associate professor of computational biology and bioinformatics, has been named winner of the 2015 Overton Prize from the International Society for Computational Biology. The prize recognizes early or mid-career scientists who are emerging leaders in computational biology and bioinformatics for their accomplishments in research, education, and service.
Huttenhower was chosen for his groundbreaking research on microbial communities, with a focus on the human microbiome. He has worked on developing novel computational tools to analyze the large, complex datasets associated with microbial communities and on the National Institutes of Health Microbiome Project. His research has provided new insights into how microbial communities impact human health and disease.
Huttenhower's research potential has previously been recognized through two other awards: the Presidential Early Career Award for Scientists and Engineers, and a National Science Foundation Career Award.


text:
C.J. Fritz, Ben Snider and Jaymical Johnson combined for 38 points Tuesday night – almost matching Rhea County's team total – as the Owls routed the Golden Eagles, 69-40, in a non-district basketball game at Ooltewah's Ed Foster Gym.
Fritz had 16 points and seven assists for the Owls (1-1). Johnson added 12 points and Snider had 10 points and eight rebounds.
Ooltewah pressured Rhea County into some early turnovers that led to transition baskets and built a comfortable 45-20 halftime lead. The Owls led 60-29 after three quarters of play.
Jarek Boyd had six points and eight rebounds for the Owls.
Logan Hunter paced the Golden Eagles with nine points.
Rhea County 11 9 9 11 – 40
Ooltewah 24 21 16 8 – 69
Rhea County (40) – Hall 2, N. Patterson 7, Bryan 4, D. Patterson 4, Crook 3, Hunter 9, Downey 2, Hill 6, Edwards 3.
Ooltewah (69) – Jaymical Johnson 12, Boyd 6, Ben Snider 10, Ross 4, Montgomery 7, Williams 3, C.J. Fritz 16, Cotheran, King 6, Wooden 5, Strickland, Hughes.
(E-mail Larry Fleming at firstname.lastname@example.com)
July 29, 2015
(click for more)
Former Tennessee All-American safety Eric Berry reported today to the Kansas City Chiefs preseason training camp. This comes a little more than eight months since Berry was diagnosed with lymphoma. ... (click for more)
University of Tennessee at Chattanooga Vice Chancellor and Director of Athletics David Blackburn announced the hiring of Troy Van Zile as the Mocs' Assistant Athletics Director for Development ... (click for more)
Former Tennessee All-American safety Eric Berry reported today to the Kansas City Chiefs preseason training camp. This comes a little more than eight months since Berry was diagnosed with lymphoma. Berry will be joining the Chiefs' quarterbacks and rookies at a three-day mini camp at Missouri Western State University, with the entire team gathering Saturday for the teams' official ... (click for more)
A woman was stabbed to death at College Hill Courts on Wednesday night. At approximately 10:27 p.m., the Chattanooga Police Department responded to 1400 Cypress Street Court for a stabbing. O fficers located a female suffering from a life-threatening stab wound. T he victim was transported by Hamilton County EMS to a local hospital where she later succumbed ... (click for more)
For the second day in a row, a Chattanooga bank was robbed by a white male. Chattanooga Police responded to Cohutta Bank in the 5600 block of Highway 153 on the report of a robbery on Wednesday afternoon. The suspect, who was reported to be unarmed, used a note to demand cash from the teller. No one was injured during this robbery. The suspect left in a ... (click for more)
The hearts, minds and prayers of Tennesseans, and of the entire nation, have been turned toward Chattanooga this month. We are sickened and saddened by the senseless tragedy, and we grieve for the families of the five service members who were killed, Gunnery Sgt. Thomas J. Sullivan, Sgt. Carson A. Holmquist, Lance Cpl. Squire "Skip" K. Wells, Staff Sgt. David A. Wyatt and ... (click for more)
America is absolutely furious! By 3 o'clock yesterday afternoon there were 36,000 people who had petitioned the White House to extradite Walter Palmer, who is today the most despised man in all of North America. On the Yelp.com website, that promotes his dentistry business in Eden Prairie, Minn, over 6,000 had posted violent, vulgar and vicious notes and, for the record, 60 of them ... (click for more)


text:
The Roots of a Nation - Cute Videos
Embed crm1 3154 views 2008-03-17T00:00:00 North America was initially settled by thousands and thousands of Christians, particularly in New England. The New World became a refugee for Christians that were persecuted in their home lands. It is important to remember there Christian roots of the past when we live in modern secular times.
More Cute Videos
- Talented Group Gives Irish Dance A Modern MakeoverMusic Videos
- Young Boy Sings 'You Raise Me Up' And Gets Every Judge To Turn AroundInspirational Videos
- Powerful American Idol Performance of Shout To The LordInspirational Videos
- Simon Stopped This 16-Year-Old Half Way Through. But You'll LOVE What She Did Next...Music Videos
- This Beautiful Version of Psalm 23 Had Me in TearsInspirational Videos
- POWERFUL Reminder That It Can Wait. Never Text Or Post And DriveInspirational Videos
- You've Got to Hear What This Groom Said at The Altar!Cute Videos
- Simon Wasn't Impressed By This Country Girl - Until She Took Him To CHURCH!Music Videos
- Kari Jobe - ForeverMusic Videos
- Michael Buble And Blake Shelton Perform Heartfelt Duet Of 'Home'Music Videos
- Sisters Of The Bride Give The Best Wedding Toast EVER!Comedy Videos
- It Only Took 10 Seconds For This Energetic Singer To Seriously Impress The Judges!Inspirational Videos
No playlists found for this account.