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On September 7, 1936, something great was lost which many do not know we even had. The thylacine, some times known as the Tasmanian tiger or wolf, was a marsupial which lived on the island of Tasmania. But like so many others, it became a victim of man. Over-hunting, a bounty scheme, and introduced species all helped to seal its fate. The last thylacine, rumored to have been named Benjamin, died on the afore mentioned date. While it has been long believed that the thylacine may have survived, undetected by man, we cannot rely on a chance rediscovery to allow it to live on into forever. If the thylacine is forgotten, man will never learn from past mistakes, and the tragic story of the thylacine may be doomed to play out again and again, sealing other animals' fates.
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- Endangered Animals
- Sep 11, 2000
- English
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Middleburg White Pages (VA)
Find People in Middleburg
Middleburg Phone Directory
Latest Phone Numbers Searched in Middleburg, VA. Use the box at the top to search the Middleburg White Pages for the owner of any phone #.
540-687-6677 - Books & Crannies LLC , PO Box 2254 (7 hours ago)
540-253-5145 - Beavers Auto Service , 4229 Bragg St (16 hours ago)
540-687-3491 - Alexandria Adventures , 103 W Federal St # F (20 hours ago)
540-592-9000 - Brian R Walker Inc , PO Box 490 (23 hours ago)
540-592-7001 - Stage Tools LLC , 34313 Welbourne Rd (1 day ago)
Other Phone Numbers in Middleburg
Unpublished Middleburg Phone Numbers
The City of Middleburg is Located in the state of VA. We have compiled the ultimate Database of phone numbers from around the state and country to help you locate any lost friends, relatives or family members. We offer the ability to search by first name, last name, phone number, or business name. We make it easy for you to find anyone, anywhere in Middleburg, VA.
Area Codes in the Middleburg, VA Region: 540
Go Back To: Virginia White Pages
Go Back To: Virginia White Pages

subset: commoncrawl


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Copyright 2014 NPR. To see more, visit http://www.npr.org/.
Years After Their Own Protests, Eyes Of Anaheim Are On Ferguson
By Erika Aguilar, NPR News Aug 26, 2014
npr news
Most Viewed News
Six 'Wild' Colorado Hot Springs To Soak Up... If You're Willing To Hike
Why Hot Yoga Might Not Burn As Many Calories As You Thought
Christian Mother And Muslim Daughter Divided, Then United, By Religion
News Story
Report: Don't Count On Colorado's National Parks For Fresh AirBy Sam Brasch
News Story
What you need to know about the Denver-Boulder US 36 express lanes tolls


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|By PR Newswire
Article Rating:
|February 10, 2014 02:37 PM EST
JACKSONVILLE, Fla., Feb. 10, 2014 /PRNewswire/ -- Beeline, a global leader in flexible workforce solutions, headquartered in Jacksonville, Florida was named a "leader," placing in the top three for current offering and market presence related to contingent staff and SOW/Services by The Forrester Wave™: VMS, Q1 2014 (February, 2014). Beeline earned the highest available score in many areas, including multigeography support, support for international laws, usability features and best practices, customer advocacy program, compliance management, and Statement of Work (SOW) functionality. Forrester Research, Inc. cites the company for "particular strength in the financials and geographic support."
"Last year, an impressive percentage of our growth came from our international and statement of work business. It is rewarding to see our investments aligned so well with the market's needs. Our focus on solving problems at a local level, while providing a complete global solution, enabled us to rapidly implement new clients and expand our existing clients' programs for managing their total non-employee workforce," said Doug Leeby, Beeline President. "Additionally, we saw an increase in the trend of companies with incumbent VMS's switch to Beeline."
Beeline ranked top two in business intelligence with the report naming Beeline as appropriate for 'companies that want a more thorough data-based approach to their contingent programs.' "This acknowledgement reflects how Beeline values the importance of clients being able to run programs based on facts, not assumptions and offers an award-winning business intelligence platform, which pairs traditional reporting with powerful analytics embedded into the business process at critical decision points," said Colleen Tiner, VP Product Management at Beeline.
Other areas where Beeline scored 5 out of 5 include VMS current offering criteria such as monitoring and event management, candidate vetting, invoice adjustments, invoice flexibility, and workflow engine.
Beeline supports some of the world's largest global companies with active programs in more than 67 countries around the world, and implementations with global clients that will soon include an additional 23 countries. Beeline VMS software-as-a-service platform offers one end-to-end solution across all countries, business units, and categories: temporary workers, professional contractors, project-based consultants, service workers, and freelancers. Every Beeline solution is delivered with powerful technology, actionable analytics, elegant user experience, flexible workflow and system configuration, unrivalled data security, and seamless integrations.
About Beeline
Beeline is a market leader in software solutions for sourcing and managing the flexible workforce. Offering intelligent workforce solutions – including Vendor Management Software (VMS) – to help procurement, sourcing, and human resources professionals optimize costs, reduce risks and add value into their local and international contingent labor programs.
Award-winning business intelligence, superior technology, global networks of local knowledge, and service-driven people based close to its clients operations make Beeline the best VMS for today's leading enterprises. To learn more, visit beeline.com
Beeline is a strategic and independently operated business unit of Adecco Group, the world's leading provider of HR solutions. The Adecco Group offers a wide variety of services, connecting more than 650,000 associates with over 100,000 clients every day and is a Fortune Global 500 Company.
SOURCE Beeline
"We've just seen a huge influx of new partners coming into our ecosystem, and partners building unique offerings on top of our API set," explained Seth Bostock, Chief Executive Officer at IndependenceIT, in this SYS-CON.tv interview at 16th Cloud Expo, held June 9-11, 2015, at the Javits Center in New York City.
Aug. 2, 2015 10:00 PM EDT Reads: 676
Mobile, social, Big Data, and cloud have fundamentally changed the way we live. "Anytime, anywhere" access to data and information is no longer a luxury; it's a requirement, in both our personal and professional lives. For IT organizations, this means pressure has never been greater to deliver meaningful services to the business and customers.
Aug. 2, 2015 07:15 PM EDT Reads: 218
Digital Transformation is the ultimate goal of cloud computing and related initiatives. The phrase is certainly not a precise one, and as subject to hand-waving and distortion as any high-falutin' terminology in the world of information technology. Yet it is an excellent choice of words to describe what enterprise IT—and by extension, organizations in general—should be working to achieve. Digital Transformation means: handling all the data types being found and created in the organizat...
Aug. 2, 2015 06:00 PM EDT Reads: 1,124
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
Aug. 2, 2015 05:45 PM EDT Reads: 505
Chuck Piluso presented a study of cloud adoption trends and the power and flexibility of IBM Power and Pureflex cloud solutions. Prior to Secure Infrastructure and Services, Mr. Piluso founded North American Telecommunication Corporation, a facilities-based Competitive Local Exchange Carrier licensed by the Public Service Commission in 10 states, serving as the company's chairman and president from 1997 to 2000. Between 1990 and 1997, Mr. Piluso served as chairman & founder of International Te...
Aug. 2, 2015 04:00 PM EDT Reads: 419
The Software Defined Data Center (SDDC), which enables organizations to seamlessly run in a hybrid cloud model (public + private cloud), is here to stay. IDC estimates that the software-defined networking market will be valued at $3.7 billion by 2016. Security is a key component and benefit of the SDDC, and offers an opportunity to build security 'from the ground up' and weave it into the environment from day one. In his session at 16th Cloud Expo, Reuven Harrison, CTO and Co-Founder of Tufin,...
Aug. 2, 2015 03:00 PM EDT Reads: 545
Container technology is sending shock waves through the world of cloud computing. Heralded as the 'next big thing,' containers provide software owners a consistent way to package their software and dependencies while infrastructure operators benefit from a standard way to deploy and run them. Containers present new challenges for tracking usage due to their dynamic nature. They can also be deployed to bare metal, virtual machines and various cloud platforms. How do software owners track the usag...
Aug. 2, 2015 02:00 PM EDT Reads: 250
SYS-CON Events announced today that MobiDev, a software development company, will exhibit at the 17th International Cloud Expo®, which will take place November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. MobiDev is a software development company with representative offices in Atlanta (US), Sheffield (UK) and Würzburg (Germany); and development centers in Ukraine. Since 2009 it has grown from a small group of passionate engineers and business managers to a full-scale mobi...
Aug. 2, 2015 12:00 PM EDT Reads: 343
With SaaS use rampant across organizations, how can IT departments track company data and maintain security? More and more departments are commissioning their own solutions and bypassing IT. A cloud environment is amorphous and powerful, allowing you to set up solutions for all of your user needs: document sharing and collaboration, mobile access, e-mail, even industry-specific applications. In his session at 16th Cloud Expo, Shawn Mills, President and a founder of Green House Data, discussed h...
Aug. 2, 2015 11:45 AM EDT Reads: 479
For IoT to grow as quickly as analyst firms' project, a lot is going to fall on developers to quickly bring applications to market. But the lack of a standard development platform threatens to slow growth and make application development more time consuming and costly, much like we've seen in the mobile space. In his session at @ThingsExpo, Mike Weiner, Product Manager of the Omega DevCloud with KORE Telematics Inc., discussed the evolving requirements for developers as IoT matures and conducte...
Aug. 2, 2015 11:15 AM EDT Reads: 354
There are many considerations when moving applications from on-premise to cloud. It is critical to understand the benefits and also challenges of this migration. A successful migration will result in lower Total Cost of Ownership, yet offer the same or higher level of robustness. In his session at 15th Cloud Expo, Michael Meiner, an Engineering Director at Oracle, Corporation, analyzed a range of cloud offerings (IaaS, PaaS, SaaS) and discussed the benefits/challenges of migrating to each offe...
Aug. 2, 2015 11:00 AM EDT Reads: 173
One of the hottest areas in cloud right now is DRaaS and related offerings. In his session at 16th Cloud Expo, Dale Levesque, Disaster Recovery Product Manager with Windstream's Cloud and Data Center Marketing team, will discuss the benefits of the cloud model, which far outweigh the traditional approach, and how enterprises need to ensure that their needs are properly being met.
Aug. 2, 2015 09:00 AM EDT Reads: 1,698
In their session at 17th Cloud Expo, Hal Schwartz, CEO of Secure Infrastructure & Services (SIAS), and Chuck Paolillo, CTO of Secure Infrastructure & Services (SIAS), provide a study of cloud adoption trends and the power and flexibility of IBM Power and Pureflex cloud solutions. In his role as CEO of Secure Infrastructure & Services (SIAS), Hal Schwartz provides leadership and direction for the company.
Aug. 2, 2015 08:15 AM EDT Reads: 183
In a recent research, analyst firm IDC found that the average cost of a critical application failure is $500,000 to $1 million per hour and the average total cost of unplanned application downtime is $1.25 billion to $2.5 billion per year for Fortune 1000 companies. In addition to the findings on the cost of the downtime, the research also highlighted best practices for development, testing, application support, infrastructure, and operations teams.
Aug. 2, 2015 07:00 AM EDT Reads: 181
The Internet of Everything (IoE) brings together people, process, data and things to make networked connections more relevant and valuable than ever before – transforming information into knowledge and knowledge into wisdom. IoE creates new capabilities, richer experiences, and unprecedented opportunities to improve business and government operations, decision making and mission support capabilities.
Aug. 1, 2015 10:00 AM EDT Reads: 335


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A big and rare session in Gwada... Too big for Le Moule !
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YORKTOWN, N.Y. - A Yorktown man was pronounced dead Thursday night after he was hit by a car near 2897 Farm Walk Road, police said.
Randy Zapakin, 57, was reportedly out walking his dog at 8:15 p.m. when he was hit by a car driven by an 18-year-old Yorktown resident. Zapakin was pronounced dead at the scene by Yorktown Paramedics, police said.
The Yorktown Police Department's Accident Investigation Team and Detective Division are currently investigating the accident.
- 1 Second Arrest Made In Animal Cruelty Case Involving Mohegan Lake Pet Shop Owner
- 2 Two Medical Marijuana Licenses Granted In Westchester
- 3 Serious Accident Takes Out Two Lanes On Taconic State Parkway
- 4 Police Officer From Mohegan Lake Sues Shoe Manufacturer After Injury
- 5 Drenching Thunderstorms Headed To Yorktown


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Get Truthdig's headlines in your inbox!
30 Years Gone, and Oh, How We Still Love Orson Welles
Paradise Burning, or Why We All Need to Learn the Word 'Anthropogenic'
WATCH: Chris Hedges: 'Marx: The System Is the Problem'
VIDEO: Larry Wilmore Slams Dentist Who Killed Cecil the Lion
'Twas the Week Before the Republican Debate
By Juan Cole $11.47
By Richard Schickel
By Nick Anderson —
Screenshot via markrussell.net
The 80-year-old political satirist came out of retirement in August when he heard that a group of Republican congressmen had drunkenly gamboled—at least one of them in the nude—in the Sea of Galilee.
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Phillies sign Cuban pitcher Miguel Alredo Gonzalez to revised deal at $36 million discount
Aug 30, 2013, 3:52 PM EDT
Back in mid-July the Phillies and Cuban right-hander Miguel Alfredo Gonzalez reportedly agreed to a six-year, $48 million contract, but that deal fell apart over concerns about the health of his elbow.
Today the Phillies announced that they've officially signed Gonzalez, but the contract is for three years and $12 million, with a vesting option for 2017. That's a helluva discount and, considering Gonzalez remained a free agent after the initial deal fell through, suggests the Phillies weren't the only team worried about his health.
Before the injury issues popped up Gonzalez was generally viewed as a potential mid-rotation starter and someone capable of getting to the majors very quickly at age 26, so if he stays healthy the Phillies may have gotten themselves a bargain by not shying away from the risk.
Corey Dickerson lands on disabled list with fractured ribs
Aug 1, 2015, 10:05 AM EDT
Dickerson has already been on the disabled list twice this season due to nagging plantar fasciitis in his left foot.
Adam LaRoche pitched a scoreless inning of relief last night
Aug 1, 2015, 9:33 AM EDT
With the White Sox losing in a rout to the Yankees last night, Adam LaRoche got a chance to pitch for the first time in his major league career. And he was pretty good too, retiring the side in order.
Rockies take John Axford out of the closer's role
Jul 31, 2015, 11:55 PM EDT
John Axford has allowed runs in five consecutive appearances, blowing four saves. He's out as the Rockies' closer for now.
There IS crying in baseball. Wilmer Flores hit a walk-off home run!
Jul 31, 2015, 11:27 PM EDT
Wilmer Flores: your feel-good story of the year.
The Orioles designated Bud Norris for assignment
Jul 31, 2015, 11:20 PM EDT
The Orioles designated struggling Orioles pitcher Bud Norris for assignment to make room for new outfielder Gerardo Parra on Friday.
Mark Melancon owes Starling Marte a nice steak dinner
Jul 31, 2015, 10:52 PM EDT
Starling Marte's defense prevented Mark Melancon from blowing a save and potentially taking a loss.
Angels place C.J. Wilson on the disabled list with elbow inflammation
Jul 31, 2015, 10:35 PM EDT
The Angels lose C.J. Wilson to an injury but are expected to get Jered Weaver back.
Mark Teixeira homers from both sides of the plate, breaks Nick Swisher's MLB record
Jul 31, 2015, 10:08 PM EDT
It don't matter if he's left or right.
The benches cleared in Friday's Giants-Rangers game
Jul 31, 2015, 9:53 PM EDT
Madison Bumgarner was upset Delino DeShields was upset.
Giants place Tim Hudson on the disabled list with a shoulder strain
Jul 31, 2015, 9:35 PM EDT
The Giants placed Tim Hudson on the disabled list, which created room on the roster for incoming pitcher Mike Leake.
Pirates place A.J. Burnett on the disabled list with elbow inflammation
Jul 31, 2015, 8:55 PM EDT
A.J. Burnett hits the DL with an elbow issue. Recently-acquired pitcher J.A. Happ will take his spot in the rotation.
Report: Padres asked Diamondbacks for Paul Goldschmidt in a Craig Kimbrel trade
Jul 31, 2015, 8:28 PM EDT
Diamondbacks GM Dave Stewart laughed when he recalled the Padres asking for Paul Goldschmidt in return in a potential trade involving Craig Kimbrel.
Video: Kendrys Morales avoids tag at the plate with a nifty slide
Jul 31, 2015, 7:49 PM EDT
Kendrys Morales is more nimble than we give him credit for being.
Yankees prospect Luis Severino's next start will be his major league debut
Jul 31, 2015, 7:20 PM EDT
Yankees pitching prospect Luis Severino will make his major league debut within the next week.
Clayton Kershaw scratched from Friday's start against the Angels
Jul 31, 2015, 6:14 PM EDT
Clayton Kershaw has been scratched from a start yet again due to a hip problem.
The Winners and Losers at the Trade Deadline
Jul 31, 2015, 5:37 PM EDT
Yes, I realize it's silly to do this an hour after the trade deadline, as time is required to see how this stuff truly shakes out. But what is the Internet for if not kneejerk reactions?
Pirates acquire left-hander J.A. Happ from Mariners
Jul 31, 2015, 4:33 PM EDT
J.A. Happ and Joe Blanton, reunited.
Pirates pick up Michael Morse from the Dodgers for Jose Tabata
Jul 31, 2015, 4:30 PM EDT
He was DFA'd by the Dodgers as soon as they got him but he may platoon at 1B for Pittsburgh.
So, the Padres sure did a whole lot of nothin', eh?
Jul 31, 2015, 4:20 PM EDT
People thought they'd make four or five trades. They ended up doing nothing.
Top Posts
- Settling the Score: Friday's results 9
- The benches cleared in Friday's Giants-Rangers game 161
- The Winners and Losers at the Trade Deadline 69
- 2015 MLB Trade Deadline Tracker 11
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- The Blue Jays pick up Ben Revere from the Phillies 65
- Cubs trade for Dan Haren 28
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- The benches cleared in Friday's Giants-Rangers game (161)
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- Rangers land ace left-hander Cole Hamels from Phillies (106)
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- Report: Rockies trade Troy Tulowitzki to Blue Jays for Jose Reyes and prospects (90)
- C. Hamels (5543)
- C. Gomez (5152)
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- J. Cueto (4046)
- M. Trout (3994)
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- Y. Cespedes (3512)
- A. Rodriguez (3487)
- T. Clippard (3252)
- J. Bruce (3247)


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Very nice looking mare,trained on trails and very athletic Wants to sale because I got extremely busy for while$1,500
Gorgeous buckskin filly out of Einstein Revolution and out of a producing Shining Spark mare. Very sweet and gentle . Beautiful loper and ready to start…$12,000
2 year old colt, beautiful and friendly. He is naturally gaited and has a nice amble. Been handled some. Beautiful stallion prospect. Has Tobe, Sam…$5,000
Calm, experienced and solid. Sound, great feet and legs. Super personality he loves cookies and cuddles. Good ground manners, mount from either side…$10,200
Bred to run!!! She is a winning granddaughter of Corona Cartel (#1 ALL-TIME LEADING LIVING SIRE OF MONEY EARNERS!!!His stud fee is $35,000!) and Calyx…$7,000
Lusitano filly born 4/30/15, expecting her to be a light/copper bay, big for her age, lots of body, strong hip and very uphill movement, dam 15.3 and sire…$6,000
Freedom 2007 Canadian Sport Horse mare sired by Snowy River (16.2 cremello Thoroughbred stallion), out of Romantic Fanfare (a 1/2 Hanoverian mare, sired…$2,500
Flashy Grey Roan show stopping gelding. Frosty is a beauty that has it all. Looks, personality, gait, style and the right attitude. He is a lovely horse…$2,800


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December 29, 2008
Health Gurus Say Resolve to Quit Smoking – One Week at a Time
A new idea that might even help Obama quit and stay quit.
"Stay Quit Monday is perfect for someone like President-elect Obama,"
"We know there's a high relapse rate for first-time quitters and that it takes a number of attempts for most people to stop smoking altogether," says
It's simple math. "For most people who quit, it takes from 7 to 10 tries," says Lerner, "We urge smokers to think about it realistically and use the start of each week to recommit to breaking their addiction. If you just try once a year on your birthday or
"Many smokers will be inspired this
"Quitting smoking is a marathon, not a 100-yard dash," said Dr.
"We think of Monday as the January of the week," says Healthy Monday President
"Expect occasional slips in your resolutions," Norcross advises. "Most successful resolvers slip in January. But a slip need not be a fall; pick yourself up and recommit to your resolution." In fact, one study Norcross cites showed that 71% of successful resolvers said their first slip had actually strengthened their efforts.
A report last year from the Institute of Medicine says that "motivating more quit attempts among people who now make none, and more frequent quit attempts among those who now try to quit" is one of five requirements for achieving higher cessation rates. (1)
Smoking is responsible for nearly one in five deaths in
Your Stay Quit Monday Toolbox
While quitting is hard, you can get help each week from HealthyMonday.org.
-- Get weekly Monday messages at About.com's quitsmoking.about.com
-- Check in with the American Cancer Society's Quitline at 1-800-ACS-2345 every week or visit cancer.org
-- Visit smokefree.gov for expert advice and tools weekly to help you stay on track
For more resources on quitting smoking and staying quit, visit the Stay Quit Monday page on the Healthy Monday website at HealthyMonday.org/stayquit.
The Stay Quit Monday campaign is a Healthy Monday project of
(1) Institute of Medicine. 2007. Ending the Tobacco Problem: A Blueprint for the Nation.
SOURCE Healthy Monday Campaign


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Berkeley, CA - Two radical groups have settled their lawsuits over an armed, over-broad police raid after the law enforcement agencies agreed to delete improperly seized computer data and pay $100,000 in damages and attorney's fees. Moreover, the University of California-Berkeley Police Department (UCBPD) acknowledged that at the time of the raid one of the groups qualified for federal protections designed to protect journalists, publishers, and other distributors of information from police searches, despite the police's persistent denial of that status throughout the lawsuit.
EFF is leading the fight against the NSA's illegal mass surveillance program. Learn more about what the program is, how it works, and what you can do.
Obama admin should require federally funded educational resources to be shared under @CreativeCommons licenses: https://eff.org/r.5xs8
MPAA wants to make websites invisible with one court order to bind them all. https://eff.org/r.unil #SOPApower
Germany's Justice Minister says he'll fire the prosecutor behind Netzpolitik.org treason accusations: https://eff.org/r.3fwl


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It's been a while since we've heard from California resident Raven Felix, whose last song was February's "Clock Strikes 12." In keeping with her last mixtape's title, Valifornia, she's now working on an album called Valifornication.
After giving us the island-influenced Trips to Trinidad EP just over ten days ago, Trinidad James is back today with another warm-weather-loving record.
"Take a peek into this piece of shit I call my life."
Stream and/or download "Don't Break It," the latest instalment in Long Beach, California emcee Cliff Savage's ongoing #SavageSunday series featuring Anaheim emcee Correy L over a refreshingly original and upbeat instrumental from Assassin MC (Correy was featur
"LKWD" is the latest offering from Jetpack Jones, produced by in-house Jetpack Movement producer Don Diestro. The cut finds the former putting a different spin on your typical hometown anthem. From the man himself:
"Time Shift" is the latest instalment in Long Beach, California emcee Cliff Savage's ongoing #SavageSunday series, produced by emerging UK beatsmith Handbook (whose name you may recognize from his work with Jetpack Jones).
Give I Do It On Purpose a spin - it's a new offering from Calikidd. It was dropped on Sunday, January 19th, 2014. Calikidd's rap artistry continues to improve with every release, something which is most definitely evidenced on I Do It On Purpose .
For those unaware, Alexander Spit is an emerging emcee/producer from Los Angeles, California. "Bitter Suite Symphony" is his first release of the new year, and is not to be confused with English alt. rock group The Verve's 1997 single of the same name.
For those unfamiliar, KR is an emerging emcee from Los Angeles, California. He's kicked the new year off with "Off The Record", a smooth new cut produced by Windsor, Ontario producer Nico Fazio. Free download. Can you dig it?
Check out Racked Up!, the latest track from Calikidd, which dropped on Sunday, December 29th, 2013. Calikidd's movement grows stronger with each new release, and Racked Up! has further strengthened that fact.
Bump Fast Life, the latest cut from Calikidd. It was released on Sunday, December 15th, 2013. Things are improving for Calikidd with each new offering, and Fast Life is certainly no exception.
"We gone, feelin' all turnt up to the max to this song / I'm already on 10, in my zone / And we ain't leavin' this bitch 'til the freaks're gone."
Check out Fed Up, the latest from Johnny Clouds. The track was released on Sunday, December 8th, 2013. Johnny Clouds's chances in this game are improving with each new release, and Fed Up is no exception - quite the opposite, in fact.
New music from Southern California's Rookie Cartrite, ya dig?
Listen to She Choosin (Remix) , the latest track from Calikidd, featuring MANN. The cut dropped on Sunday, November 24th, 2013. Calikidd's future brightens with every new release, and She Choosin (Remix) certainly isn't an exception.
Green OVA Underground 's musical situation is improving with every new release, and Go Outside will most definitely help the cause. It's a fine addition to the growing body of work Green OVA Underground has been developing since stepping foot in the game.
Check out The Daniels (Prod. By Red Vision) , the latest from Mann. The track was released on Monday, September 2nd, 2013. Mann's chances in this game are improving with each new release, and The Daniels (Prod.
Listen to Higher Calling (Prod. By Subdaio & Oikazi), the new track by Jetpack Jones, which was dropped on Monday, July 22nd, 2013. Jetpack Jones's odds keep getting better with each new leak, and Higher Calling (Prod.
Give The Deep End (Prod. By O. Skeeters & C.Wills) a listen - it's a new offering from Jetpack Jones. It was dropped on Wednesday, July 10th, 2013. Jetpack Jones's musical situation is improving with every new release, and The Deep End (Prod. By O.
Things are looking better for Cliff Savage with each new release, which Late Nights & Early Mornings has proven yet again. It's worthy addition to the impressive body of work Cliff Savage has been developing over the years.
Bump Cali Luv, the latest cut from Snow tha Product. It dropped on Thursday, May 16th, 2013. Snow tha Product's horizons are broadening with each new release, and Cali Luv is no exception.
A highlight from Mann's Lisa Simpson inspired new EP of Love Inspired Stoner Anthems for 4/20, featuring Ty Dolla $ign. Produced by DJ Mustard and Ty$'s production team, D.R.U.G.S.
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Buddy Bench Encourages Friendship
FRISCO (CBSDFW.COM) – A second grader's idea to help fellow classmates who may feel lonely is spreading fast through school campuses in Frisco.
Abbie Hanson, 8, came up with the idea of what she called a "buddy bench.
"You can sit on the buddy bench and surely someone will come over and be your friend," said Hanson. She said when a child sits on the buddy bench, it's a signal to other kids that they want to play.
It's a simple idea, which is helping solve the complex problem of children feeling ostracized by classmates. Second grader Leah Biju used the bench at Shawnee Trail Elementary School.
"I was feeling lonely and sad because I didn't have any friends," said Biju. It didn't take long for another student to notice Biju sitting alone on the bench. "I saw a girl… I saw a girl that I had no idea who she was was and I said 'do you want to play catch with me?' and then we became BFFs," said second grader Valerie Askey.
Hanson's buddy benches have grown in popularity in the last four months at Shawnee Trail Elementary School. There are now benches at 14 other schools.
"I love it, that was very inspiring to see for a second grader," said school counselor, Cyndi Steward.
More than a tool to bridge the gap between new and current students, buddy benches fit in with Frisco's emphasis on making students feel accepted. Thus, improving overall performance in the classroom.
(©2014 CBS Local Media, a division of CBS Radio Inc. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.)
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Enter your login details for Respiratory Medicine Case Reports below. If you do not already have an account you will need to register here.
Recent Respiratory Medicine Case Reports Articles
Recently published articles available on ScienceDirect.
Is percutaneous tracheostomy the best method in the management of patients with prolonged mechanical ventilation?
Available online 1 August 2015
Duilio Divisi | Giovanni Stati | Andrea De Vico | Roberto Crisci
Although percutaneous tracheostomy is a standardized procedure, rare major complications are still being evaluated and discussed. We describe a case of patient, with hemodynamic and respiratory stability,...
Mucormycosis causing pulmonary artery aneurysm
Available online 31 July 2015
Lakshman Ramachandran
Pulmonary artery aneurysm (PAA) is an uncommon entity and is usually congenital in origin or secondary to pulmonary arterial hypertension. Infections causing PAA are few, tuberculosis and bacterial...
Update on the Spectrum of Histoplasmosis Among Hispanic Patients Presenting to a New York City Municipal Hospital: a Contemporary Case Series
Available online 29 July 2015
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Histoplasma capsulatum is the most common endemic mycosis worldwide. Although most of the globe's largest urban hubs fall outside this organism's regions of endemicity, clinicians practicing in a metropolis...
A rare clinical case- Solitary fibrous tumor of the pleura
Available online 29 July 2015
Alexis Papadopoulos | Ilias Porfyridis | Gregorios Christodoulides | Andreas Georgiou
We present a case of a 58 years old man with a large heterogeneous and well circumscribed soft tissue mass arising from the right pleural surface, found at a computer tomography of his chest. This mass...
Successful management of pulmonary hemorrhage and aspergillosis in a patient with acute myeloid leukemia (AML-M3)
Available online 26 July 2015
Hulya Gunbatar | Cengiz Demir | Erdal Kara | Ramazan Esen | Bunyamin Sertogullarindan | Selvi Asker
A 35-year-old man presented with a one month history of gingival bleeding. He was diagnosed with Acute Myeloid Leukemia (AML-M3). During treatment he developed alveolar hemorrhage for which he was treated...
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Available online 23 April 2015
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Cystic Fibrosis (CF) is a multisystem disease predominantly affecting the airways and predisposing patients to recurrent infections with various multidrug resistant organisms. Mycobacterium tuberculosis...
Pulmonary melioidosis presenting with pleural effusion: A case report and review of literature
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Melioidosis is a serious infection, which can involve multiple systems. We report a case of pulmonary melioidosis with the initial presentation mimicking a partially treated pneumonia complicated by...
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Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency in adults and children. We herein report a case of CVID, who was misdiagnosed with asthma due to wheezing episodes...
Delayed diagnosis of hemoptysis in the case of prior aortic coarctation repair: A case report of aortobronchial fistula
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We report a case of a 46-year old man who presented with spontaneous bright red blood per mouth for several months. The patient had history of aortic coarctation repair at age 17. Endoscopy and nasopharyngeoscopy...
Tuberculosis mimicking lung cancer
I. Hammen
Tuberculosis (TB) is well known as a diagnostic chameleon and can resemble malignancy. In thorax TB can be manifested as pulmonary infiltrates and/or mediastinal lymphadenopathy. In low incident countries...
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Recreational use of alkaloid free-base cocaine, also known as crack cocaine, has reached epidemic proportions in the United States. Inhalation of crack cocaine is known to cause a variety of pulmonary...
Postcardiac injury syndrome following vascular interventional radiofrequency ablation for paroxysmal atrial fibrillation
Shungo Yukumi | Hiraku Ichiki | Junichi Funada | Hideaki Suzuki | Masamitsu Morimoto | Teppei Fujita | Naoki Izumi | Masahiro Abe
Postcardiac injury syndrome (PCIS) occurs following a pericardial or myocardial injury. On the other hand, PCIS following cardiac catheter intervention is rare and can be difficult to diagnose because...
Microscopic polyangiitis preceded by combined pulmonary fibrosis and emphysema
Kyoko Gocho | Keishi Sugino | Keita Sato | Chikako Hasegawa | Toshimasa Uekusa | Sakae Homma
A 73-year-old male metalworker was admitted to our hospital with a 3-year history of progressive dry cough. Chest high-resolution computed tomography revealed emphysematous changes and reticular lesions,...
Hypersensitivity pneumonitis caused by the broom grass (Calluna vulgaris)
Yusuf Aydemir | Adil Can Güngen | Hikmet Çoban
Hypersensitivity pneumonitis (HP), is an inflammatory disease that represents one possible response of the interstitial and parenchymal tissue to the intensive and repeated inhalation of organic dusts...
An unusual presentation of pulmonary epitheloid hemangioendothelioma
Jaya Prakash Sugunaraj | Claire Pedroso | Shravan Kethireddy | Mohammed Mogri
Pulmonary epitheloid hemangioendothelioma (PEHE) is a rare, often incidentally diagnosed, endothelial tumor of the lung. We present a case of a young adult who presented with acute hypoxemic respiratory...
Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature
Sharon W. Hung
Acute eosinophilic pneumonia (AEP) can be a challenging diagnosis and is often initially misdiagnosed as one of the more common pneumonia syndromes such as acute respiratory distress syndrome. Early...
Palliative embolisation for intrapulmonary shunting in lepidic predominant adenocarcinoma of the lung
Joanne Yue-Ai Tan | Darren L. Walters | Karl Poon | Paul Zimmerman | Pat Aldons
Lepidic predominant adenocarcinoma (LPA) (formerly known as bronchioalveolar carcinoma) has rarely been reported to cause refractory hypoxia with intrapulmonary shunting [1–7]. We describe a case who...
Multifocal primary amyloidosis of the airways: Case report and review of the literature
S.M. Lang | D. Täuscher | J. Füller | A.H. Müller | H. Schiffl
Primary localized amyloidosis of the airways is an uncommon disorder characterized by amyloid deposits in the airway mucosa. In contrast to systemic amyloidosis other organs are not involved. Among...
Inflammatory bowel disease of the lung: The role of infliximab?
Adam J. Hayek | Timothy P. Pfanner | Heath D. White
Pulmonary extra-intestinal manifestations (EIM) of inflammatory bowel disease are well described with a variable incidence. We present a case of Crohn's disease with pulmonary EIM including chronic...
Microscopic polyangiitis associated with pleuropericarditis, pulmonary embolism and pulmonary hemorrhage as a complication of silicosis
Amjad Al-Rajhi | Elisa Ferreira Brega | Neil C. Colman
Silica (silicon dioxide) occupational exposure has been linked to both pulmonary and extra-pulmonary toxicity. Silicosis is the major pulmonary toxicity, which has also been associated with the development...
An aggressive, solitary non-healing ulcer: Not always cancerous
Karl Daraius Mehta | Alamelu Haran | Ajit Harsha | Gopi K. Gulikari | Rachna Kaul
Fusobacterium necrophorum presenting as isolated lung nodules
Rajiv Sonti | Christine Fleury
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Diffuse vascular hamartoma with malignant behavior
I. Ladeira | S. Neves | J. Almeida | B. Parente | A. Couceiro | J. Moura Sá
Pulmonary hamartomas are benign lesions, usually asymptomatic and incidentally discovered on a routine chest radiograph; occasionally, however, this benign lesion may cause life threatening symptoms...
Successful treatment of chronic lower respiratory tract infection by macrolide administration in a patient with intralobar pulmonary sequestration and primary ciliary dyskinesia
Hironobu Tsubouchi | Nobuhiro Matsumoto | Shigehisa Yanagi | Jun-ichi Ashitani | Masamitsu Nakazato
Primary ciliary dyskinesia (PCD) is a genetic disease associated with abnormalities in ciliary structure and function. Although recurrent respiratory infection associated with ciliary dysfunction is...
Fatal pulmonary hemorrhage after taking anticoagulation medication
Samuel P. Hammar
We describe a 64-year-old man with extensive diffuse acute lung hemorrhage, presumably as a result of anticoagulation therapy. We evaluated reports in the literature concerning acute exacerbation (acute...
Unilateral pulmonary vein atresia: A rare case of hemoptysis
Cindy S. DeMastes-Crabtree | Edward Kim | Ronald L. Morton
We present a rare case of hemoptysis secondary to isolated unilateral pulmonary vein atresia. Isolated pulmonary vein atresia is a rare condition in which patients typically acquire a diagnosis in infancy...
A case of pulmonary lymphangioleiomyomatosis complicated with uterine and retroperitoneal tumors
Takanori Numata | Jun Araya | Jiro Mikami | Hiromichi Hara | Tohru Harada | Hiroyuki Takahashi | Katsutoshi Nakayama | Kazuyoshi Kuwano
A 39-year-old female experienced dyspnea on exertion for eight months. Chest CT demonstrated findings of Lymphangioleiomyomatosis (LAM), including diffuse thin-walled cystic lesions. A surgical lung...
A case of Trousseau syndrome caused by pulmonary adenocarcinoma that was controlled for one year and 10 months with thrombosis treatment using an EGFR tyrosine kinase inhibitor and chemotherapy
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A 47-year-old female with no history of previous illnesses developed cerebral infarction and was diagnosed with lung cancer, specifically EGFR mutation-positive adenocarcinoma, and Trousseau syndro...
Glutaric aciduria type 2 presenting with acute respiratory failure in an adult
Ebru Ortac Ersoy | Dorina Rama | Özlem Ünal | Serap Sivri | Arzu Topeli
Glutaric aciduria (GTA) type II can be seen as late onset form with myopathic phenotype. We present a case of a 19-year old female with progressive muscle weakness was admitted in intensive care unit...
Dark sputum: An atypical presentation of primary pulmonary malignant melanoma
Alida Filippini | Fausto Zorzi | Claudio Bna' | Antonio Arnaboldi | Tony Sabatini
Primary melanoma of the lung is an extremely rare clinical entity. We found only 32 cases reported in literature, and in two of these multiple brain metastases were present. We describe a case of primary...
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Scrotal wall metastasis from a primary lung adenocarcinoma
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This a case of a 77 years old male heavy smoker, known to have Combined Pulmonary Fibrosis and Emphysema complicated by a primary invasive adenocarcinoma of the lung with bone metastasis, who presented...
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Diffuse alveolar hemorrhage, a life-threatening disease, can complicate various conditions. We herein describe, for the first time, a patient with diffuse alveolar hemorrhage caused by exposure to organic...
Iatrogenic "buffalo chest" bilateral pneumothoraces following unilateral transbronchial lung biopsies in a bilateral lung transplant recipient
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We present a 54 year old male patient who had a bilateral lung transplant sixteen years ago for Alpha-1 Antitrypsin Deficiency-related emphysema. He was referred for flexible bronchoscopy with transbronchial...
Chronic mould exposure as a risk factor for severe community acquired pneumonia in a patient requiring extra corporeal membrane oxygenation
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A previously fit and well man developed acute respiratory failure due to environmental mould exposure from living in damp rental accommodation. Despite aggressive intensive care management he rapidly...
Pneumothorax triggered by the combination of gefitinib and amrubicin and treated with endobronchial silicone spigots
Fumio Imamura | Norio Okamoto | Takako Inoue | Junji Uchida | Kazumi Nishino | Madoka Kimura | Toru Kumagai | Jiro Okami
Pneumothorax is a rare complication in cancer chemotherapy. We report a case in which a male patient with advanced non-small cell lung cancer (NSCLC) developed repetitive pneumothorax after receiving...
Pneumonia and disseminated bacteremia with Pasteurella multocida in the immune competent host: A case report and a review of the literature
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Pasteurella multocida is primarily an opportunistic infection, most commonly of skin and soft tissue following animal bites particularly in the elderly and immunocompromised. While invasive disease...
Bronchopulmonary Kaposi's sarcoma
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Kaposi's sarcoma (KS) is a highly vascular tumour, which was first described by the Hungarian dermatologist Moritz Kaposi Kohn before the discovery of the human immunodeficiency virus (HIV). Historically,...
Rash, disseminated intravascular coagulation and legionella: Episode 10 and a rewind into the past
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Legionella pneumophila is the most common cause of legionellosis and is one of the organisms causing atypical pneumonia. We report the presentation of disseminated intravascular coagulation (DIC) and...
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We report the first case of spontaneous chylothorax complicating small cell lung cancer. A 52 year old female presented with exertional dyspnoea, left-sided chest and neck pain, and dysphagia. The chest...
Delayed post-lobectomy pulmonary artery stump thrombosis
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We present a 67 year old male patient who underwent VATS right upper lobectomy with en bloc chest wall resection and right lower lobe superior segmentectomy for atypical Ewing Sarcoma. Serial chest...
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|By Marc Middleton | January 09, 2013 | Comments
Source: F4WOnline- The internal belief is that RAW will stick to three hours at least through WrestleMania 29, reports The Wrestling Observer. This doesn't mean that it will go back to two hours after WrestleMania but there will definitely not be a change between now and then. There are top officials who believe that going to three hours hasn't been good for the product.
- WWE announced today that their "be a STAR" alliance has reached 25,000 pledges to stop bullying. Fans can take the pledge at beastaralliance.org.
- Here's the latest episode of WWE Inbox, which features Superstars discussing who has the coolest tattoos and gimmicks they are happy to not have been given:
Got a news tip or correction? Send it to us by clicking here.
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Taz Weighs In On Hulk Hogan Controversy, Says He Thinks Hogan "Is Done"
Today In Wrestling History 7/29: Kevin Nash Uses Rey Mysterio As A Dart, Jake Roberts Turns, More
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Written on: 23/12/2013 by rebel-uk (1 review written)
Contacted this company to book 4 flights to Orlando, I was quoted a price which was competitive, I agreed to book the flights and was told that before I could pay I would have to send an email with the names of the persons travelling, I was assured that once recived they would telephone me back within 5 minutes.
Having sent the email immediately I waited and I waited !!!!! after 3 days I contacted them by telephone again and was not offered any apology but was informed that the flights were no longer available but could still be booked at an addition cost of £80-00 per person.
This company is absolutely rubbish - AVOID THEM AT ALL COST
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You seem not to know about America's financial contribution to the Islamist-Jihadist countries in the Middle East and Southern Asia-Afghanistan and Pakistan. America has poured billions of dollars into these countries. What a waste of America's taxpayers' money! America should stop wasting money on these scoundrels and use the money to improve its ailing economy and eliminate its skyrocketing deficits.
Nusra Front in Syria says it has detained U.S.-trained rebels (Reuters)
from the article: Likudniks blast 'enemy of the Jews' Obama over settlement freeze


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Immigration reshaping the political landscape
Published on Sun, Aug 23, 2009
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Support the Council today as we work to ensure that families and individuals have access to the critical legal assistance they need and aggressively advocate and litigate to end family detention.
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Dinning Room Table & 5 Chairs
Dinning room table and chairs. good family size table/ chairs brown leather type. 5 in total one has slight damaged/wobbly leg 150 cms x 90 cms
Dinning room table and chairs. good family size table/ chairs brown leather type. 5 in total one has slight damaged/wobbly leg 150 cms x 90 cms
This has to be 1950's extendable dinning table . Standard size is 36" 92cm x 33" 84cm . The extendable leaves are 12" so it is versatile. 60" max length then 48" with the first flap open. The top has a small water damage but this would rub down .
I'm selling my lovely pine dinning table as its too big for new kitchen it will seat 6 people easily and is a good solid table. It is in antique pine stain. Wear n tear as u would expect but still looks lovely after a good polish. It does have a slig
A very nice brand new looking 6 people dinning table, with 6 creamy chairs. The table can be folded to suit smaller families if needed so, it's an immaculate condition used for 2 months. Please contact me directly if interested.
ideal for using and easily tucking away into a corner when not needed. cash and collect only please. phone me on 07740076666
Good condition wood 4 chairs in green. Selling just because i have no space for it. Fell free to view. I am a bit deaf so i just answer text message. Tks Samantha
Hi here I have a good condition dinning table but no chairs this has one little scratch on it all in all a good table Hight 28 inches Depth 33 inches Width 60 inches This will fit 6 people collection charminster many thanks
Table and 4 chairs light wood and metal frame great condition hardy used cash on collection
Ducal polished pine dinning table with 4 chairs and matching dresser strip interior light in glass cupboards
Eden Oak Dinning Table with 6 chairs, 3 black leather and 3 gray fabric chair. We are planning to change to smaller tablet. We rare use this table and its always has cover on the top of the table so its in excellent condition like new. Width 180cm,
For sale , wooden dinning table , great condition, nearly new . length 117cm Width 80cm
Circular glass dinning table with four chairs in good condition a few minor scratches on glass surface . Chairs are good one has light stain as shown in photo still all round good dinning set Diameter of table 100 cm Height 76 cm
Large 6 seater table with middle section in glass, Second hand table, bought 2 years ago, About 1,6 m by 0,9m good condition willing to sell as we are moving soon
Glass Topped Half Moon Side Table Dimensions: 74cm Wide 76cm High 38cm Deep £35 or nearest offer. Free delivery within a five mile radius. Viewing by appointment only.
Dinning room table 4 chairs and 2 arm chairs, table extends 07857396933
it is lots of home and garden appliances a long with lots of woman's clothing and shoes are for sale as we are moving to a smaller property.
Drop leaf pine dinning table. Both sides drop down for easy storage . This is a solidly constructed table, but it needs refinishing.
Very good quality high gloss lounge / dining furniture. Units light up and have mirrored backs. height 82' width 58' depth 16'. Table 63' x36' which has a removable extension of another 16' . Brand new cost £5600. reluctamt sale due to house move
In good condition and has middle extension 4 side chairs and 2 end arm chairs. Available now £250 ono
Bought from David Phipps in Ferndown at over £3,000 ! Extends and in good condition. New replacement is the only reason for selling. It is made by a specialist provider and will last a lift time or more! Collection only and happy for you to come
Two matching dinning chairs in excellent condition, ideal as extra for guests.
Clear and black glass oval dinning table Selling as brought smaller one Buyer to collect On other sites
Dining Room table with glass top and marble base for sale in v good condition, 4 x black leather chairs,2 x smaller side tables with glass tops and marble bases matching dining room table, Collection only No time wasters
This Dinning table with 4 chairs in good condition. Must clear by this weekend, Hurry UP!!!
Black and clear glass Excellent condition Selling due room change and got smaller one On other sites Collection only £50 ovno
4 Shabby chic dinning room stools Please do come and view at Latimer House, Christchurch to see what other pieces we have. We can deliver for a nominal charge. Tel .01202 477600
Glad table metal frame with cream leather effect seats only selling due to moving beds gone ASAP thanks


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Database administrator jobs in New York, NY1,836 Jobs
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- HR GeneralistApply on Glassdoor• Prepares and maintains employee handbook policies and procedures manual • Performs benefits administration to include claims resolution, changeReliant Realty Services, LLCReliant Realty Services, LLCNew York, NYSponsoredSave
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Catherine Ashton (C, L), High Representative of the Union of Foreign Affairs and Security Policy for the European Union, and Iranian Foreign Minister Mohammad Javad Zarif (C, R) attend the second day of the second round of P5+1 talks with Iran at the UN headquarters in Vienna, Austria on March 19, 2014. AFP PHOTO / DIETER NAGL
Iran says will ban US experts from UN nuclear inspections
N. Korea blames US for stalled nuclear dialogue
US envoy on N. Korea says Iran deal proves flexibility
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Iran and six world powers began an expert-level meeting about Tehran's nuclear program on Thursday, part of efforts to reach an agreement by late July on how to resolve a decade-old dispute that has stirred fears of a Middle East war.The meeting in Vienna of nuclear and other experts from Iran and the United States, France, Germany, Russia, China and Britain was to prepare for a new round of higher-level negotiations next week, also in the Austrian capital.Iran says its enrichment program is a peaceful bid to generate electricity and has ruled out shutting any of its nuclear facilities.Robert Einhorn, a former senior U.S. State Department official dealing with Iran, said the positions of the parties -- especially the United States and Iran -- remained far apart.
Iran says will ban US experts from UN nuclear inspections
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text:
The three-dimensional structure of the transport protein TSPO opens up novel paths for the diagnosis and treatment of brain diseases
Joint press release of the DZNE and Max Planck Institute for Biophysical Chemistry
The word "cholesterol" is directly linked in most people's minds with high-fat foods, worrying blood test results, and cardiovascular diseases. However, despite its bad reputation, cholesterol is essential to our wellbeing:
It stabilizes cell membranes and is a raw material for the production of different hormones in the cell's power plants – the mitochondria. Now, for the first time, scientists in Göttingen have solved the high-resolution structure of the molecular transporter TSPO, which introduces cholesterol into mitochondria.
This protein also serves as a docking site for diagnostic markers and different drugs, such as Valium. The detailed knowledge of its three-dimensional shape and function opens up new diagnostic and therapeutic perspectives.
Not only are mitochondria the most important energy supplier in living cells. They also produce steroid hormones such as testosterone and oestradiol, which control many processes in the body. The raw material for the production of steroid hormones is cholesterol, which must first be transported into mitochondria across two membranes.
This difficult task is carried out by a molecular transport protein named TSPO in the outer mitochondrial membrane. Using nuclear magnetic resonance spectroscopy, two teams working with the Göttingen-based scientists Markus Zweckstetter and Stefan Becker have now shown the complex three-dimensional structure of the protein "at work" in atomic detail.
The researchers achieved this methodical breakthrough by applying an ingenious trick: In their experiments, they coupled the transporter to an important diagnostic marker called PK11195; it was this complex that first gave the scientists analyzable results. In fact, the TSPO structure delivers more than just clues about how cholesterol is transported into the mitochondria.
"We now also have a much better understanding of how TSPO recognizes and binds to diagnostic markers and drugs", explains Markus Zweckstetter, head of research groups at the German Center for Neurodegenerative Diseases (DZNE), at the Max Planck Institute for Biophysical Chemistry, and at the Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) at the University Medical Center of Göttingen (UMG).
TSPO has long been successfully used in diagnostics and treatment of a number of diseases. "When the brain is injured or inflamed, its cells produce more TSPO. This fact is used in the diagnosis of neurodegenerative diseases such as Parkinson's and Alzheimer's", explains Stefan Becker, a protein chemist and Max Planck researcher who works next door to Zweckstetter.
Physicians also use radioactively tagged molecules such as PK11195 to visualize inflamed areas of the brain. A detailed understanding of how TSPO binds to such markers opens up novel paths for diagnostic imaging and could constitute an important step along the way to early detection of such diseases and inflammations.
TSPO also binds several medicinal drugs such as diazepam, also known by the trade name of Valium. Not only is diazepam a widely prescribed sedative; it is also used in the treatment of anxiety and epileptic seizures. The Göttingen researchers hope that detailed information about the transporter's structure will help to develop new TSPO-binding drugs.
Original publication
Łukasz Jaremko, Mariusz Jaremko, Karin Giller, Stefan Becker, Markus Zweckstetter. Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science 21 March 2014: Vol. 343 no. 6177 pp. 1363-1366 DOI: 10.1126/science.1248725
Prof. Dr. Markus Zweckstetter
Research Group Structural Biology in Dementia
German Center for Neurodegenerative Diseases (DZNE)
Research Group Structure Determination of Proteins Using NMR
Max Planck Institute for Biophysical Chemistry
University Medical Center Göttingen
+49 551 201-2220
Dr. Stefan Becker
Project Group Molecular Biology
Department of NMR-based Structural Biology
Max Planck Institute for Biophysical Chemistry
+49 551 201-2222
Dr. Carmen Rotte
Press and Public Relations
Max Planck Institute for Biophysical Chemistry
+49 551 201-1304
Dr. Marcus Neitzert
Press and Public Relations
German Center for Neurodegenerative Diseases (DZNE)
+49 43302-271
Markus Zweckstetter | EurekAlert!
Further reports about: > Biology > Biophysical > DZNE > Molecular > Valium > cholesterol > diseases > drugs > mitochondrial > protein
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Arizona's immigrant driver's license policy blocked
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PHOENIX (AP) -- Reyna Montoya is one of nearly 19,000 young immigrants in Arizona who have been allowed to stay in the U.S. under the Obama administration's deferred action policy, but the benefits of the program in the state have been limited.

 As Montoya applies for teaching jobs, she considers herself competitively disadvantaged because Arizona hasn't allowed her to get a driver's license as the federal policy allows.

 She was among those cheering a decision by a federal appeals court that on Monday ruled the state cannot deny driver's licenses to immigrants in the program. The three-judge panel of the 9th Circuit Court of Appeals suggested the policy was intended to express hostility toward the young immigrants, in part because of the deferred action policy.

 "We are celebrating now, but we are going to have to continue to organize," Montoya said, noting that it's not the only example of difficulties she and others face.

 Montoya said her counterparts in Arizona often struggle to pay for college, because the state requires those receiving deferred action assistance to pay out-of-state tuition, which is more expensive.

 The program was created by the Obama administration in 2012 to help immigrants younger than 30 who came to the U.S. illegally as children. Applicants must have been in the country for at least five continuous years, enrolled in or have graduated from a high school or GED program or have served in the military. Aside from allowing driver's licenses, the program also permits young immigrants to pursue a two-year renewable work permit.

 States have imposed various restrictions on benefits such immigrants are able to obtain, and Arizona's denial of licenses was one of the most visible challenges to the Obama administration's deferred deportation policy. A separate court battle is playing out in Arizona over a community college system that wants to grant in-state tuition to the immigrants - an effort the state attorney general has challenged.

 Arizona was one of two states that refused to issue licenses to the immigrants, sparking the latest court fight over the issue.

 Republican Gov. Jan Brewer called the ruling misguided and said she was considering appeal.

 The appeals court ruling follows other high-profile battles between Arizona and the federal government over immigration, including court decisions that struck down much of a 2010 enforcement law but upheld its most hotly debated section, which requires police to check immigration status under certain circumstances.

 "We hope that this ruling signals the end of what has been an unfortunate anti-immigrant period in Arizona," said Karen Tumlin, one of the attorneys representing the immigrants.

 The decision should remove any barriers young immigrants face in getting a driver's license in Arizona, Tumlin said.

 The ruling comes during a national focus on the topic as tens of thousands of immigrants from Central America - many unaccompanied children - have illegally entered the country in recent months, straining the capacity of detention centers along the U.S.-Mexico border.

 Brewer issued an executive order in August 2012 directing state agencies to deny driver's licenses and other public benefits to young immigrants who get work authorization under the deferred action program.

 Brewer pointed out that the judges who ruled against her were appointed by Democratic presidents. The governor blames Obama's policy for the recent influx of immigrants entering the country illegally and notes that the program isn't federal law. "Lawless decrees by the president demonstrate animus to Congress, states and the Constitution," Brewer said.

 The appeals panel ordered a lower court judge to issue a preliminary injunction blocking Brewer's executive order while the case is litigated. It's unknown how long it will take for the case to conclude.

 Brewer's attorneys said the decision to deny driver's licenses grew out of liability concerns and the desire to reduce the risk of the licenses being used to improperly access public benefits.

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Government has sought suggestions on a draft paper to frame policy on the capital goods industry, envisioning an increase in its contribution from 12 per cent at present to 20 per cent of the total manufacturing activity in the country by 2025.
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Geete also urged industries to come forward and make use of the Capital Goods Scheme notified by the Department of Heavy Industries (DHI).
The Met department today forecast heavy to very heavy rainfall in isolated places in western Meghalaya issuing an alert in that region.
Desai said government is keen on reducing employment based on agriculture & thus preference is being given to industrial growth over environment.
Uttarakhand MeT department today issued a warning predicting heavy rains and landslides in the high altitude districts for two days beginning tomorrow.
The Prime Minister, who spent about an hour, discussed various ways to expand cooperation in naval defence, LNG carrier construction and shipbuilding technology.
Presenting picturesque hilltop tourist location Patnitop as a round-the-year destination, the J&K tourism department has launched an aggressive marketing and promotional campaign to woo tourists from Punjab.