text: Related articles All News Articles Media Reviews 30° Watch Dogs Retrospective: Were We Wrong To Judge It So Harshly? 5d ago - AG from EGMR writes: "Watch Dogs released in May last year to brewing dissent thanks to Ubisoft's... | Culture Comments (0) t0asty Source 70° The PlayStation Now games you need to stream 6d ago - PlayStation Now is bringing PS3 titles to you via the cloud. Here are 10 games you need to play. | PS3 Comments (10) jonyami Source Ad Filmwatch Contest Details Now - Come celebrate Independence Day with us on Filmwatch and win cool prizes. | Promoted post Read More SiteBot 40° The worst modern videogame endings 7d ago - MyGaming: "A videogame ending is vital to its lasting appeal; it can make or break a great story,... | Culture Comments (0) Biggy420 Source 150° Which of the Xbox Ultimate Game Sale bargains should you pick up? 7th-13th July 2015 22d ago - Neil writes "Unless you've won some kind of lottery, or scooped a big win on your football accuma... | Xbox 360 Comments (15) neil363 Source 40° Ubisoft Needs to Be Honest in Marketing to Avoid Unity and Watch_Dogs Like Disasters 22d ago - SegmentNext - Ubisoft is a firm that once was the creator of some of the best gaming franchises i... | PC Comments (1) WiredX Source


text:
Service was good, need to review markups on items as they were a bit high.
All of our items arrived in great condition. Even the fruit we ordered was fresh. We will definitely order through Garden Grocer on our next visit!
Absolutely the best! I will never go to Disneyworld again without using Garden Grocer! THANK YOU so much!

subset: commoncrawl


text:
Comments about 'BYU has short turnaround time to clean up its offense for game against Boise State'
- Oldest first
- Newest first
- Most recommended
Ahhhh! The sweet smell of independence. Apparently, independence also means
being ESPN's lackey. Playing the late game on Saturday and then having the
short turnaround to play on ESPN's thursday night matchup to soak up as
much of that national limelight as possibly was exactly what they wanted. The
only problem is, after last saturday, they don't look to be up to the task.
This problem isn't the players fault, it was created by the adults who are
in charge who may not have had the firmest grip on reality when they scheduled
these games.
Good luck to the Cougs on thursday. If they win they get all the respect in the world. At least one Bronco is gonna get busted on Thursday night. I'm betting it's the one that resides in Provo. BYU wanted to be like their independent big brother Notre Dame. If they don't win thursday they'll looking more like the other two Army and Navy.
- 12:22 a.m. Sept. 18, 2012
- Like
- Report abuse
1. I would think that after a tough loss, BYU would be very anxious to get back
on the field. I would look for a very motivated team to go into Boise, even with
the short preparation period.
2. The noise problem can be overcome. BYU was depending too much on verbal queues rather than visual cues. I would be very surprised if they did the same thing in Bronco stadium.
3. If you are the visiting team, listening to "Utah Man" being played over and over can drive you insane. This is especially true when the fans keep coming onto the field to personally sing it to you. After surviving that experience I would think that BYU could put up with just about anything.
I give the edge to BYU in this one.
- 12:08 p.m. Sept. 18, 2012
- Like
- Report abuse
A thought about Thursday night games:
This would apply to both the pros and college.
After watching the pathetic Packers/Bears game, I came to my own conclusion that teams shouldn't play on 3-days rest.
The solution? Instead of having a BYE week, it would be included in a Thursday night scenario.
That is, a team with a Thursday night game would NOT play the Sat/Sun before the Thurs game. This essentially gives them a bye week if you count the extra days before and after the Thursday night game.
If a team is scheduled to play a week-4 Thursday night game, they don't play week-3 and then they have a long week until week-5. This allows for a hidden bye week and allows the players to heal and for more preparation.
Having played college football, there is no way I'd want to play a Sat then a Thurs game.
And because of studying no college should play on Sunday. Getting home from a long away game at 4 am Sunday morning is bad enough. Getting home early Monday morning means you miss all your classes for sleep so you can show up for practice.
- 4:38 p.m. Sept. 18, 2012
- Like
- Report abuse
DeseretNews.com encourages a civil dialogue among its readers. We welcome your thoughtful comments.
— About comments
- Guard Elijah Bryant announces he is...
- Dick Harmon: Big 12 expansion talk (ahem,...
- Utah makes top 7 for 4-star offensive line...
- Cougars say they have learned lessons in wake...
- Morning links: Devontae Booker to be Utah's...
- 4-star basketball recruit Connor Harding...
- Whittingham dishes on stadium expansion,...
- Utah Utes football: Ranking the best players...
- Phil Steele gives tempered assessment... 77
- Morning links: Utah is on the rise in... 74
- Cougars say they have learned lessons... 65
- Utah makes top 7 for 4-star offensive... 46
- BYU looking for another defensive... 33
- Morning links: Tom Hackett is the Utes'... 31
- Utah Utes backup quarterback Donovan... 29


text:
Find the perfect hotel in Zwijndrecht using our hotel guide provided below. Explore our guide for inexpensive and discount hotel/motel rates in or near Zwijndrecht, Netherlands for your personal leisure or group travel. We show the best Zwijndrecht hotel/motel rooms. Review the Zwijndrecht hotel list below to find the perfect lodging. We also have a map of the Zwijndrecht hotels.
Zwijndrecht Hotels, Motels & Accommodations
Next 20 Zwijndrecht Hotels > [1 - 20 of 50]
Next: See My Zwijndrecht Hotels with Pricing >


text:
1 of 1 people found the following review helpful
My first ever kindle book,
This review is from: David Copperfield (Kindle Edition)
Now I am a kindle girl, official entry to the 21st Century has finally been made! I love this story. After trying to read it at age 9 or 10 and struggling, I decided to attempt it again. It was amazing. I felt that more than any other of Dickens' stories this was the embodiment of so many of Dickens' own life experiences. The reader can't help but sympathise with Copperfield, while following him throughout his life. A real feel-good Dickensian cracker.
Review Details
(831 customer reviews)
Out of stock
Top Reviewer Ranking: 704,527


text: The hotel was clean and situated very nicely away from the bar noise from the center, but there was some noise from the ambulances of the nearby hospital. Breakfast was quite normal Italian - not very much anything green, mainly bread and pastries. Room was kept clean and cool and the pool area was nice after long and hot days... More


text:
Kepler-452b revolves around a sun much like our own.
TB Screen Glows Green
February 13, 2012|
Infection by GFP-encoding viruses enables quick, easy detection of tuberculosis in patient samples.
February 13, 2012|
Infection by GFP-encoding viruses enables quick, easy detection of tuberculosis in patient samples.
February 13, 2012|
As institutions around the world start celebrations of Darwin Day, New York reveals a digitized catalog of Darwin's scientific manuscripts.
February 7, 2012|
Only a quarter of Clostridium difficile infections in one hospital system were traced to contact with a symptomatic patient.
February 3, 2012|
While biotechnology has met with mixed public reactions, to date nanotechnology seems to invoke much less public concern.
February 2, 2012|
A database manager stole NIH grant funds, falsified data, and lied about it.
February 1, 2012|
The US National Science Advisory Board for Biosecurity explains why it recommended redacting the details of studies reporting on a highly transmissible H5N1 strain.
February 1, 2012|
In Chapter 1, editors Barbara Oakley, Ariel Knafo, and Michael McGrath introduce the concept of well-intentioned behaviors that go awry.
February 1, 2012|
Neurogastronomy, Why Calories Count, The Kitchen as Laboratory, Fear of Food
February 1, 2012|
In 1842, Anna Atkins, a 43-year-old amateur botanist from Kent, England, began experimenting with a brand-new photographic process called cyanotype or blue-print.
February 1, 2012|
How to successfully surmount the challenges women face in becoming biotech industry leaders


text:
The Annual Iron Hill Twilight Criterium Rolls Into West Chester Saturday, August 8 http://t.co/KHwHc4yEhV http://t.co/lS6yLPGhKt
One Week Out! Night Market Philadelphia Hits Lancaster Avenue Thursday, August 6 http://t.co/iKurEprUZK http://t.co/GBMl7fGSgv
Stay Cool: Top 14 Spots For Cold-Brew Coffee In Philadelphia http://t.co/h2LU4zeo8C http://t.co/YS7cVIYEo0
Today! @PHLVisitorCntr marks 30 million visitors w/ giveaways like #FREE @Phillies tix, @RitasItalianIce & more! http://t.co/eQ92FRbeHN
Check out our guide to this Sunday's 2nd Street Festival in Northern Liberties: http://t.co/GLIHvuXSJP http://t.co/2yw6sEGjpf
Deal Feed: Use code VISITPHILLY to get 2-for-1 tickets to roller skate at RiverRink Summerfest http://t.co/njvmQrTMkp http://t.co/t6OYDgnVod
Sweet. The BlackStar Film Festival Starts Tomorrow, July 30: http://t.co/ayOCXzFkK9 http://t.co/TKENiBD620
Receive $25 off tickets to the @PhillyMag Best Of Philly Soirée with code VISITPHILLY! http://t.co/LepKtUpdqO
Awesome Event Alert: Shakespeare in Clark Park kicks off tonight at 7pm and it's free! http://t.co/aSWigisO7T http://t.co/jNvqc6S5If
December 3, 2012
Posted by Allison Stadd
Posted on December 3, 2012 | Allison Stadd
Filed in:
Attractions, Dining, News
Tonight's a big night for Philadelphia. Anthony Bourdain has finally done a show in Philadelphia… and that show — the Philadelphia episode of Anthony Bourdain's The Layover — is finally set to air tonight, Monday, December 3 at 9 p.m. on the Travel Channel. Take a look at our guide to where to watch […]
October 11, 2012
Posted on October 11, 2012 | Allison Stadd
Filed in:
Attractions, News
UPDATE: The Philadelphia episode of The Layover is set to air on Monday, December 3 at 9 p.m. Remember when Travel Channel star Anthony Bourdain was in town shooting a Philadelphia episode for the upcoming second season of his show The Layover? In just over a month, we'll get to see those shots on the […]
October 1, 2012
Posted on October 1, 2012 | Allison Stadd
Filed in:
Dining, News
The super popular fried chicken and donuts shop Federal Donuts, co-owned by Michael Solomonov, restaurateur Steven Cook, coffee aficionados Thomas Henneman and Bob Logue and food-and-drink expert Felicia D'Ambrosio, is expanding to Center City. This Wednesday, October 3 at 7 a.m., Federal Donuts will open its second location at 1632 Sansom Street. We. Cannot. Wait. […]
September 14, 2012
Posted on September 14, 2012 | Allison Stadd
Filed in:
Dining, Hotels, News
The opening of Philadelphia's first new hotel in Old City's Historic District in years is now quickly approaching, with the ribbon-cutting of The Hotel Monaco Philadelphia on Independence Mall slated for October 11 (everything will be open officially on October 4). One of the most exciting aspects of the latest Kimpton property in Philadelphia (the Hotel […]
June 15, 2012
Filed in:
Attractions, Hotels
Today's Philly 101 video features Nick Gregory, General Manager of the future Hotel Monaco Philadelphia, opening on Independence Mall in September of this year.
We were fortunate enough to get a sneak peek inside the hotel, thanks to the great Kimpton team, and we're sharing it with you here.
Check it out to get more intel about Hotel Monaco Philadelphia, and learn what Nick wishes more people knew about in Philadelphia.
Hotel Monaco Philadelphia — Opening September 2012!
433 Chestnut Street
Independence Mall
Independence National Historical Park
5th and Chestnut Streets
Today's Philly 101 video features Nick Gregory, General Manager of the future Hotel Monaco Philadelphia, opening on Independence Mall in September of this year. We were fortunate enough to get a sneak peek inside the hotel, thanks to the great Kimpton team, and we're sharing it with you here. Check it out to get more […]
Tagged as:AttractionsFamily FriendlyHistoric PhiladelphiaHotel MonacoHotelsIndependence MallKimptonOld CityPhilly 101Philly 101 Video SeriesSneak PeekVideo
May 15, 2012
Posted by James Zale
Posted on May 15, 2012 | James Zale
Filed in:
Arts, Attractions, Events, News
When the new Barnes Foundation opens to the public on May 19, 2012 — this Saturday (!!) — the world's largest collections of Impressionist, Post-Impressionist and early Modern paintings — including 181 Renoirs, 69 Cezannes, 59 Matisses, 46 Picassos and 7 Van Goghs — will join the already amazingly robust museum district along the Benjamin […]
May 1, 2012
Posted on May 1, 2012 | Allison Stadd
Vernick Food & Drink from Cherry Hill native Chef/Owner Greg Vernick opens tonight, May 1, off Rittenhouse Square. We got a sneak peek at the spot last Friday. The verdict? Pretty impressive. Here's a quick rundown on this new neighborhood bistro: The Inspiration The Vernicks (Greg and his wife Julie) infused much of their observations […]
April 27, 2012
Posted on April 27, 2012 | Allison Stadd
Filed in:
Hotels, News
The opening of Philadelphia's first new hotel in the Historic District in years is now quickly approaching, with The Hotel Monaco Philadelphia now slated for a September debut on Independence Mall. The project is an adaptive reuse development of Philadelphia's historic Lafayette Building at the corner of 5th and Chestnut Streets in the heart of […]
February 16, 2012
Posted on February 16, 2012 | Allison Stadd
Bruce is back! The National Constitution Center's marquee exhibition From Asbury Park to the Promised Land: The Life and Music of Bruce Springsteen opens its doors to the public tomorrow, Friday, February 17. The exhibition kicked off with a rockin' opening party last night, the biggest opening in the Constitution Center's history, and will be […]
February 13, 2012
Posted on February 13, 2012 | Allison Stadd
Just in time for Valentine's Day, Andrew and Kristin Wood will open Russet, a cozy and casual BYOB on the first floor of a lovely brick townhome, the former home of Ernesto's Cafe, just steps from Rittenhouse Square. We got a sneak peek at the restaurant, and from the warmth of the chefs to the […]


text:
HomeAbout UsContact
AdvertisingMap Sign in
Farm Houses
Bed & Breakfast
Choose where to stay on the map of Calabria
Regione Calabria
Bed and Breakfast Conte RuggeroCity: Serra San Bruno Zone: Centro
B&B Conte Ruggero is the ideal place both for business and leisure stays; it offers to its guests all modern comfort.
Located in a splendid palace of 1800, completely renovated and restored to its original splendor, it keeps unchange... Property details - Map
Bed and Breakfast La PerticaCity: Castrovillari Zone: Centro
Our B&B is situated just in the center of the town but plunged into a 2.000 metres orchard full of olives trees ,chestnuts, pines, and fruit trees.
The house is not far from The Ionian sea, appreciated both for its desert beaches and... Property details - Map
Holiday Apartment IreneCity: Scalea Zone: Centro Storico
Holiday Apartment Irene is a pretty apartment situated in the heart of the historical centre of Scalea, near Cosenza in Calabria, South Italy.
The apartment is ideal for 2 to 4 people, and has been recently refurbished and nicely decor... Property details - Map
Bed and Breakfast SybarisCity: Cassano Allo Ionio Location: Marina Di Sibari Zone: Mare
Bed & Breakfast Sybaris is a comfortable villa surrounded by a lovely verdant garden, 200m from the beach of fine white sand.
The B&B offers accommodation in comfortable rooms in Marina di Sibari Tourist Center, 2 km from the archaeologi... Property details - Map
Bed and Breakfast Casa GemmaCity: Lamezia Terme Zone: Centro
Casa Gemma Bed and Breakfast, situated on a hill, will give you the opportunity to admire a beautiful panorama: just in front the Villa the luxuriant plain of Lamezia Terme, the great Calabria's Sea, and in the limpid days, the wonderful su... Property details - Map
Disclaimer & Privacy
LinkTour.it © 2005 by


text:
Berlin 2013: Barbra Streisand Signs Directing Deal With Aldamisa International
UPDATED: She's reportedly considering several projects, but no further details were available.
BERLIN -- Barbra Streisand might return to the director's chair for the first time since The Mirror Has Two Faces in 1996.
Los Angeles-based sales and financing outfit Aldamisa International said Friday that it has struck a directing deal with Streisand, though no title was announced. She reportedly is mulling several projects.
PHOTOS: European Film Market 2013: 10 Titles to Track in Berlin
"We are thrilled to provide underwriting for a filmmaker of her vision, stature and accomplishment," said Aldamisa president of international sales and acquistions Nadine de Barros, who is in Berlin at the European Film Market.
Mark Manuel's Kilburn Media will provide financing. Aldamisa co-chairman Sergei Bespalov will produce alongside de Barros.
Streisand seems to have renewed interest in her movie career. Over Christmas, she appeared in The Guilt Trip, her first starring role since The Mirror Has Two Faces.
Never miss a story. Stay up-to-date with THR's Daily Headlines.
Must Reads
Derek Jeter, The Aspiring Media Mogul (Who Dislikes Media), Reveals Next Big Swing
Ghost of Amy Pascal Haunts Sony's Sad Summer
How Leonardo DiCaprio's 'The Revenant' Shoot Became "A Living Hell"
Dr. Dre, Ice Cube Break Silence on N.W.A Movie, Suge Knight's Murder Charge and a Reunion Tour (With Eminem)
Lena Dunham, Amy Schumer and Comedy Actress A-List in Raunchy, R-Rated Roundtable


text:
on 25.09.2012
firstname.lastname@example.com: "Nice work guys you are the best store in Europe.Keep up the nice work, Your efficiency is you best advertising! from Greece"
on 30.04.2013
email@example.com: "I have never dealt with another musical supplier who are as prompt, helpful and expansive as you. Keep up the great work"
on 01.07.2014
Ante, from Croatia: "Profi and fast!!! Thomann is something special."
This item is in stock and can be dispatched immediately.
Sennheiser 37974 - replacement headphone cable with 3,5mm (mini-) jack for old 400 series, HD 222, HD 224, HD 230, HD 250, HD 414, HD 420, HD 424, HD 425, HD 430, HD 440, HD 442, HD 450/ Reference, HD 450 II, HD 480, HD 490 II, HD 50, HD 520, HD 530, HD 540/ Reference, HD 560, (not HD25). Cable length: 300cm
Tip: Turn on the interactive glossary function to automatically display explanations of technical terms.
Payment can be made safely and securely with Credit Card, Bank Transfer, PayPal or Amazon Payments.


text:
What are you listening to right now? V4
Mr. Robot Discussion Thread
How to install Win 10 properly?
Quiz; Can you guess this movie? V10
Windows 10 for file-sharing
The Danger Zone
KickassTorrents is moving to kat.cr domain
Happy Torrents Day 2015!
Technical maintenance (March, 17)
Extra Extra, Read All About It! The Katalyst Issue #3 - July 2015, OUT NOW !!
This could be my last night in this world...
**27 July 2015** India loses its RocketMan. :(
Move Over IOT, The Internet Of Sound Is Here
A change is as good as a rest......
Paris, my city
presets adobe
moneytalks emily kae
sweetheartvideo lesbian beauties
dancing with the stars
think and grow rich
midnight run
jon english
the brink s01e02
vijay iyer


text:
Folk News
News on Folk continually updated from thousands of sources around the net.
27 Gay Celeb Couples Who Are Married or Engaged
Same Sex Marriage: It's Officially Legal
American Terrorism: Plain and Simple
Trending Now
Most People Arent Smart Enough to Solve These Riddles Are You?
20 Celebrities' Stunning Final Words Before Dying
Can You Guess The Answer To These Crazy Old-School Etiquette Questions?
19 Celebrity Men Who Totally Nailed Why Men Should Be Feminists Too
24 Times Celebrities Wore Dead Animals and Thought They Looked Good
Updated: Mon Aug 03, 2015 11:53 pm
Copyright © 2015 Topix LLC


text:
Motoexotica is pleased to introduce to you a Super Sweet little 1923 Ford T-Bucket. This Aqua Blue beauty was built to drive and enjoy.... More
A mean looking T-Bucket here. Restored in 2015 and out fitted with leather interior, this ride surely stands out. Powered by a 5.0L V8... More
1923 Ford model T small block ford C4 Auto `T bucket` 64` Corvette IRS White/Black interior vin 7814... More
We have a very roadworthy 1927 Ford Model T Roadster Pickup ready to drive, enjoy or put to work. Last year for the model... More
1923 Ford T-BucketDetails-Excellent conditionautomatic 400 transmissionChevy 305 motorNeon road lights underneath.3000 miles on motor5200 miles overallCustom PaintNo rustPlease call Dana at 315-246-2294 emails will... More
One of the oldest and most popular ways to go fast was to strip down a Model T Ford roadster to the bare essentials,... More
Here is an outstanding 1927 Ford Model T Roadster. All original Ford steel finished in a Vermillion red with black fenders. New Lebarron bonney... More
GROUND UP RESTORED. BEAUTIFUL 2 TONE PAINT WITH VARNISHED WHEELS. THIS MODEL T HAS ELECTRIC START & FIRES RIGHT UP. RARE WORKING MAGNETOS, SWITCH... More
Here's a fun little T-bucket for the car shows and cruise nights! This one has a 327 Chevy small block, dual quads on a... More
Tudor Sedan, older resto, good body, nice redone int, runs/drives good.... More
Model T Coupe, nice original car, good body and paint, nice redone interior, runs/drives good.... More
Ford Model-T 1924 roadster restored in very good condition This Ford Model-T is in a very beautiful condition and well maintained. It has the original... More
1921 Ford Model T Pickup Older full restoration Oak wood cab & flat-bed Removable glass windows & windshield Electric start MotoeXotica is pleased to present a true piece of automobile... More
1926 Ford Model T Touring Car Beautifully Restored. Silver, with a black interior. This piece of American history is in amazing restored condition, down... More
1921 Ford Model T ConvertibleThe T-Ford Speedster is true classic car from the beginning of the 1900's which is designed and developed by Henry... More


text:
Users Online Now:
Who's On?
Visitors Today:
Pageviews Today:
Threads Today:
Posts Today:
Join Our:
GLP Poker Rooms
Check Out:
GiveMeGossip.com - Gossip Forum
Donate To GLP
Adv. Search
Back to Forum
Back to Thread
Message Subject
what are the advantages and disadvantages of declaring personal sovereignty???
Poster Handle
Post Content
Money is not imaginary. Money is a division of worth of labor. Since I can trade my Dollars for goods and services and I must provide goods or services to make more of that imaginary money- it has value because we agree it does.
The barter system is too hard. I need some Apples but my skill is Home building (not really, but...) there is no way to really trade this- So we provide a "perceived value" attached to the currency (be it Gold, Silver , paper or electronic) which I can parcel out into smaller purchases.
Funny the people who keep hawking this "Imaginary paper fiat money" ideal will gladly take your Dollars for their services (and spend them) and will gladly take your imaginary paper dollars for their "real" Gold.
Again, Philosophically speaking you are correct. real World application, not so much.
Goodmen 16778386
Federal Reserve NOTES are not money, they are "legal tender" states it right there in black and white.
There you go, projecting your beliefs on a NOTE and calling it "money", your premiss is flawed because you are ignorant.
Anonymous Coward 20901334
Its Debt (if you wish to get technical)- But....
Money is a generic term. You work, your paid, you spend...Money.
Goodmen 16778386
It is not a generic term, the law of the land in the Republic is clear on what is legal tender for debts and has been since before this nation existed.
There are many forms of legal tender and there are contractual forms of lawful money, but that is a matter of agreement between two parties and is NOT the law of the land, but is contractually binding (and therefore lawful).
You are a novice at this, I can tell.
Keep trying, you might learn something.
Anonymous Coward 20901334
It was a generic term in my usage since this thread isnt about money, legal tender or currency and this whole line was a sidetrack since the whole "Money is a fiction" came up.
Anyhow, I wouldnt consider myself a novice on monetary policy but no expert either. In fact, I have read a couple books which touched on it and watched a few you tube vids (like Money masters and Money as Debt) but my take was on the Anthropological use of money- i.e. barter is impossible on a large scale so we break our labor into ...Money.
But yes, Money is not something I have extensively studied (nor plan to) but its real enough that it keeps me in a warm dry house, food in my belly and occasionally a few beers. I couldnt possibly barter with all the people who provide services for me- So...It works. =)
Plus you guys need to use a damn name tag- I am not sure if you are the FMOTL guy or someone else. Seriously...
Please verify you're human:
Reason for reporting:
Cecil The Lion Wants Everyone To SHUT UP, Animal Psychic Claims
Facebook Readying Test of Internet Beaming Drone
Alien Hybrid Found In India
True Story of Satan, Fallen Angels, Giants, Aliens, Hybrids, Elongated Skulls & Nephilim
Antidepressants May be Worsening Depression, Not Treating it
New Tech Allows Face Recognition in Utter Darkness
Federal court rules that air fresheners and pro-cop stickers are a reason to pull you over
Medicare for all: Bernie Sanders calls for single-payer health system
For the first time ever, scientists spot an aurora outside our solar system
Will the Internet listen to your private conversations?
The Military Will Test a New Terrifyingly Loud Noise Directed Energy Gun
University of California offers six choices for 'gender identity'
Hackers Claim John McCain Knew ISIS Execution Videos Were Staged
Why Are They Hosting a Weird Occultic Dance Opera Inside CERN?
Seattle's Nanny State is "Deputizing Trashmen as Secret Police" to Snoop Through Wastebins
Chattanooga Hoax? Victim Reported Dead Years Before Shooting
European Researchers Warn the World of the Dangers of Climate Engineering
New Legislation Would Place Breathalyzers in All New Cars
Transhumanist Candidate Wants "Brain Implants to Manage Violent Actions of Prisoners"… And Society
Are Salmon Dying from Hot Water in Northwestern Rivers, Or Could It Be Something Else?
New Online Petition Seeks to Make Traffic Fines Based on One's Income
Edible Vaccines: What's in your Banana?
Gold Manipulation: It's Much Bigger Than You Think
ALEC Behind Recent Push For Mandatory Vaccination
American Town is Cell Phone and Wi-Fi "Quiet Zone", Sanctuary for EMF Sensitivity
This Flag Represents The Principle, "Fight For What You Believe In."
This Is The Rebel Flag, "You're Either Free Or You're Not."
Disclaimer / Copyright Info
Privacy Policy
Terms Of Use
with questions or comments about this site.
"Godlike Productions" & "GLP" are registered trademarks of Zero Point Ltd. Godlike™
Website Design Copyright © 1999 - 2015 Godlikeproductions.com
Page generated in 0.004s (3 queries)


text:
- Entire Place
- Listings where you have the whole place to yourself.
- Private Room
- Listings where you have your own room but share some common spaces.
- Shared Room
- Listings where you'll share your room or your room may be a common space.
- Room Type
- Price
- Size
- Social Connections
- Employee host
- Instant Book
- Superhost
- Neighborhoods
- Amenities
- Property Type
- Host Language
1000+ Rentals · Winthrop
1000+ Rentals · Winthrop
Have everything you need at your fingertips in this private room of our 4th floor walk-up in the historic South End neighborhood of Boston. Learn More
Queen size bed, desk, and closet storage. The room is approx 9x14 and features an exposed brick wall. The queen bed is new and comfortable to sleep on, extra pillows and blankets are provided as well as towels, bottled waters, and travel size toiletries in case your forgot or need something. The room also has a small desk with a neighborhood map and other tourist brochures. Guests have full access of our spare room with plenty of space to store luggage. The rest of the common areas are ...
South End, Boston
One bedroom of a three bedroom apartment in kenmore square in Fenway! Located right in the heart of the city. Well furnished and cleaned regularly. Plenty of space including common room, kitchen, and bathroom, also has a rooftop view of the city! Price negotiable! Learn More
Fenway/Kenmore, Boston
Cozy studio with all amenities. 5 min walk to Newbury Street & all the shops, Trinity Church, and Green Line (Copley Station) - Unit features Loft Queen bed, flat screen w\Netflix, free WiFi, fridge, small stove, electric kettle, & full bath. Learn More
This is a great space for one or two people. Clean, well maintained and has a great view of the John Hancock tower as well as the Berkeley building and its weather beacon. The unit is a located on the 5th floor and is a walk-up. You are welcome to use any of the kitchen equipment. Both Trader Joe's and Star Market within walking distance. Located right in the heart of Back Bay, this is the perfect location to explore the city from. Close enough to walk to any of the sites or enjoy the fab...
Back Bay, Boston
ECO green apartment has everything you need in heart of city. Super large roof deck, next door free gym, private attached deck, in room free laundry, club house with pool game, cable TV-Internet, basement free parking. Close to BU, BC, LMA, few min walk to T and shops. Duang! Learn More
Allston-Brighton, Boston
Sun-drenched deck and screened porch on a hill, with dinette, couches, grill and umbrella. Near bike path and T, this calm space in a two-family house includes a full kitchen, bedroom, office, living room, dining room and a yoga room. Learn More
The deck and porch are a great place to relax during the day, then grill and watch the sun set at the end of the day. If it is nice at night, it is fun to read or play a game inside the screened-in porch. The house sits on a hill in the back, with a little yard. The house itself is very quiet, with wood floors and lots of space. There is a new bike path about two blocks away behind the Salemwood elementary schoo. There is easy car access to Boston, Somerville, Cambridge and area beaches. Y...
Private bedroom in cozy ocean front home, spectacular views of Boston Harbor and Skyline. Comfortable single bed with desk in the room. Enjoy access to front porches inside and out with wireless internet avaialble throughout. Enjoy access to the living room, tv, and dining room. The House is conveniently located down the block from the beach. There's a short walk to Blue Line Train.
East Boston, Boston
This private bedroom in a great location has a full bed and clean linens/towels. Enjoy access to a full kitchen, living room with TV, and clean (shared) bathroom. Free wifi, laundry access in building, and one block from major train (T) lines. Learn More
This private room comfortably sleeps up to 2 in a full size bed. It is nicely decorated with clean linens and has two large windows. We do have two (adorable & friendly) cats but we generally keep the door shut to this private room so they don't have access. In the apartment, you'll have access to a full kitchen, shared bathroom, and cozy living room. This is a city apartment so it isn't huge, but there is plenty of space for 1-2 guests. We provide complimentary coffee, tea, and fluffy ...
Allston-Brighton, Boston
LAST MINUTE BOOKINGS WELCOME! Only a few blocks from Harvard, Porter Square and the MBTA! Set back from the street, makes for a quiet stay. Complimentary fresh coffee and tea and the most comfortable bed in all of Cambridge! Learn More
Last minute bookings welcome! Experienced vacation rental manager and coffee/tea lover has furnished this wonderful sun-lit rental with high-quality linens and luxuriously comfortable mattress, toiletries, up-to-date info about museums and local attractions, and we keep the place warm and extremely clean. Please note this is a 3rd-floor walk-up. As little or as much as you would like. We are very easy going! Your room is very private, so you can keep to yourself if you wish. Th...
Gorgeous, brand new converted factory loft studio, just 5 minutes walk to South Station! By tons of trendy bars and restaurants. Learn More
Gorgeous, comfortable modern loft with a full kitchen. 520 foot studio, 13 foot ceilings, tons and tons of beautiful natural light.
South Boston, Boston
Our lovely garden studio has a direct door from the side walk and its very private. It's in the historic Beacon Hill just two blocks to the post office in Charles Street, and the T red line at Charles/MGH. Walk everywhere, its a fantastic location. Learn More
It's a great studio, very spacious with a queen sized bed, 5 windows, 3 to the street and 2 to the back. One in the kitchen, which is a big separate room, and one in the bathroom. Air conditioner is installed now for the summer. To the entire apartment all to yourself. Meet and greet / and then via text once or twice, until check out. It is the best neighborhood in Boston, the very first settlement in the hill. Very close to the State House, Cheers (the bar from the sitcom), Boston Commo...
West End, Boston
This beautiful apartment is bright and vibrant, has COOL central AC, a modern kitchen equipped with contemporary appliances, washer & dryer inside apt. HD 60" TV! Super safe & clean! 4.3 mi. from Boston, 6 mi. to Harvard & 6 mi Revere Beach. Learn More
This contemporary one bedroom apartment is fully furnished and equipped with all kitchen appliances, including washer and dryer inside the apartment. The bathroom is big and offers a nice big tub for relaxing baths or showers. There is wall to wall carpeting. 3D, HD 60" TV, WI-FI, cable and NetFlix. Guests can enjoy free morning coffee, in the brightness offered by big windows! Free garaged parking! (1 car only). Access to a gym inside the complex. Business center. Free washer & dr...
Located at the heart of Cambridge, MA, this is a comfortable and clean self-contained private room. Wooden floor & stair case, access to a nice kitchen space and fully furnished living room with 3 other occupants. 10 minute walk to the subway and bus Learn More
A private room in a charming three bed, two bath condo located on Pope's Hill with gorgeous finishes and unique features. Unbeatable views of downtown Boston from the private back deck. Stunning kitchen, wood fireplace, and minutes from the redline. Learn More
A private room in a charming three bed, two bath condo located on Pope's Hill with gorgeous finishes and unique features. This second floor condo offers unbeatable views of downtown Boston from the private back deck for outdoor entertaining. Stunning modern kitchen with custom back splash, stainless steel appliances and hammered copper sink, granite counter and plenty of cabinets. This amazing condo features very nice, spacious and bright dining and living room with working wood fireplace. ...
Dorchester, Boston
The condo of 1200 square feet is recently renovated and elegantly furnished. The photos do not do justice to this sun-filled and well -organized condo. This No 2 bedroom is nicely furnished with desk, queen size bed and closet. Clean towels, blanket, slippers, and clean sheets are available during checkin. One common bathroom and one adjacent living room. Wireless internet, big storage, spacious living room, eat in kitchen and parking on the street or designated spot. Big fridge to store food...
Just minutes from the Porter Square T, this spacious & renovated 2+ bed condo faces leafy Raymond Park. Easy access to Rte. 2, Harvard and Davis Squares, & many options for great food, live music, Zipcars & shops. Queen bed, full size open up sofa. Learn More
This spacious renovated condo, built in 1916, features lots of character: high ceilings, hardwood floors & many updates throughout. It's all that a small family could ask for. Enjoy a relaxing morning coffee on the private screened porch, relax in the Jacuzzi, or if you really need to work, you can make use of the office area. The condo faces leafy Raymond Park, a neighborhood gem perched at the crest of Avon Hill. The sunny south facing living room & connected dining room lead to the wel...
Private bedroom with doulebed and kitchen privileges available for temporary stay. Located in a brick two-family home on Boston harbor, this house has spectacular views of the ocean, airport and Boston skyline. Enjoy access to the porch inside and out, with wireless access available throughout. Safe neighborhood, convenient to blue line, shops, restaurants and beach. Across from airport, parking available.
East Boston, Boston
Just down the street (literally) from red line subway, convenient to downtown, financial district, MIT, UMASS, Harvard. Nearby gym, restaurants, grocery, bank. Private room with queen bed, Ikea storage, 2 closets. Shared renovated kitchen, bath. Learn More
Home was built in 1890, so has a lot of historic flavor and layout, but totally updated and renovated recently. Cozy private room with queen-sized bed, 2 closets, Ikea storage unit that doubles as a desk, 2 windows for light and air. Shared renovated kitchen, bathroom, and living room. Bathroom is huge, with awesome modern shower, a laundry area, AND a jacuzzi tub. Kitchen has stainlesss steel appliances and granite tops. Living room has comfy couch and a nice flat panel TV with cable. W...
Dorchester, Boston
A gorgeous room in a home that is almost 100 years old! Close to Boston, Cambridge and airport. Please read "The Space" section as it is based on feedback from my previous guests. My home is a few bus stops from the subway. Thanks! Learn More
This is a great neighborhood and an airy room with lots of natural light and a large dine-in kitchen. I really enjoy hosting and meeting folks from all over the world (and across the street too!) I will be happy to welcome you in my home. Look forward to meeting you! Some notes based on feedback received from my previous guests to help your visit! * At times there maybe other Airbnb verified guests that share the common spaces and bathroom * My home is not directly off a subway. A bus sto...
Instant Book
Book without waiting for your reservation to be accepted


text:
It would be nice to replace the old mpeg2enc plugin
with the new version of the mjpegtools project which is
more rich of features. To do that, it will be necessary
to add support for YUV4MPEG file format...
Logged In: YES
I have created a rough patch so cinelerra uses an external
mpeg2enc if anyone is interested. I've only tested it on pal
dvds etc. but it works ok
see http//:www.johnwilks.com
and look at the stuff page


text:
Shop by
Refine by
Premier RTA Living Room Furniture
Premier RTA
at Overstock
at Overstock
Simple Connect means fast easy assembly. No tools are required. This unique assembly process sets the standard for Ready to Assemb...le furniture. Transform any room with our Colfax 60 media console. This stylish unit is designed to complement many dcor styles and holds up to most 60 flat panel TVs. To accommodate your media needs, console has 3 adjustable shelves, one fixed shelf for electronic components and one functioning drawer, for additional media storage space. 2 beveled framed glass doors have hidden hinges and accented with brushed nickel hardware. Neatly organize your components with our magnetic back panel feature. Simple, functional and beautiful are the words that best describe this Colfax 60 Entertainment Stand. read more


text:
Author's email address P. A. Fraser: firstname.lastname@example.com
Two components of blood-brain barrier disruption in the rat
Article first published online: 30 SEP 2004
DOI: 10.1111/j.1469-7793.1997.613bg.x
The Journal of Physiology
Volume 503, Issue 3, pages 613–623, September 1997
Additional Information
How to Cite
Easton, A. S., Sarker, M. H. and Fraser, P. A. (1997), Two components of blood-brain barrier disruption in the rat. The Journal of Physiology, 503: 613–623. doi: 10.1111/j.1469-7793.1997.613bg.x
Publication History
- Issue published online: 30 SEP 2004
- Article first published online: 30 SEP 2004
- Received 11 March 1997; accepted 04 June 1997.
- Abstract
- Article
- References
- Cited By
- 1Permeability of pial venular capillaries to Lucifer Yellow (Ply) was measured using the single microvessel occlusion technique.
- 2P ly was extremely low, when measured shortly after the removal of the meninges, consistent with an intact blood-brain barrier, but rose spontaneously to (1.65 ± 060)× 10−6cms−1 (mean ±s.d.) within 20–-60 min. This first phase of spontaneous disruption lasted 44–164 min. A second phase started when Ply rose sharply, and was characterized by rapid permeability fluctuations with a mean of (12.31 ± 15.14) × 1CT−6 cm s−1.
- 3The first phase could be mimicked by applying the divalent cation ionophore A23187 in the presence of Ca2+, when Ply rose by (1.47±0–25) × 10−6 cm s−1 (mean±s.e.m.). Application of histamine (10 μm) to tight vessels increased Ply by (2.41 ± 0.22) × 10−6 cm s−1.
- 4Substances that raised intraendothelial cAMP of vessels during the first phase of disruption reduced Ply to the initial blood-brain barrier level.
- 5The second phase could be prevented by applying catalase. Similar high and fluctuating Ply values could be produced reversibly by applying arachidonic acid or NH4C1.
- 6This is the first report of two distinct types of permeability increase in the cerebral microvasculature, and reasons for this are discussed.
The relative restriction to fluid and solute movement which is ordinarily present between blood and brain breaks down in a number of pathological states, such as trauma, stroke and epilepsy. It is possible to disrupt the blood-brain barrier in a number of different ways experimentally, but different laboratories have reported a large range in values for the increased permeability (see Greenwood, 1992). It is possible that methodological differences are responsible for these discrepancies, and convection of tracer molecules is one variable that is not often controlled. Experiments on single pial microvessels have been designed to measure diffusive permeability alone (see Easton & Fraser, 1994a), but even these techniques have given different results. Thus Olesen & Crone (1986), who estimated permeability from trans-microvascular electrical resistance in frogs, showed that in response to bradykinin, serotonin, ATP, ADP, arachidonic acid and oxygen free radicals the endothelial resistance fell from 1000 to 600 Ω cm2, which is equivalent to a small increase in sucrose permeability from 0.45 to 0.75 × 10−6 cm s−1. Similar small increases were observed by Butt & Jones (1992) in rat pial vessels after superfusion of histamine and bradykinin. These reports contrast with a much larger increase in permeability (from unmeasurably small to 20 × 10−6 cm s−1) of the traumatically disrupted pial microvessels of the frog, measured from the rate of escape of a fluorescent fluid-phase marker using the single vessel occlusion technique (Fraser & Dallas, 1993). Similar large increases were found during the superfusion of hyper-osmolar sucrose (Fraser & Dallas, 1990) and these observations compared well with whole brain studies in the rat (Rapoport, Fredericks, Ohno & Pettigrew, 1980). On the other hand, Butt, Jones & Abbott (1990), using electrical resistance measurements, reported that superfusion with hyperosmotic mannitol resulted in only small changes, similar to those found with histamine. There is also agreement between single microvessel and whole organ studies of the effects of histamine (Gross, Teasdale, Graham, Angerson & Murray Harper, 1982; Butt & Jones, 1992), so it is possible that despite differences in technique being responsible for different permeability values, different stimuli may cause different degrees of blood-brain barrier disruption.
The experiments described here were carried out in an attempt to establish whether the different results obtained in single microvessels were due to methodology alone, or if they reflect distinct types of permeability increase. We have studied permeability changes that occur spontaneously after removing the dura and arachnoid and found that there are qualitative differences that occur over time. A preliminary account of some of the results has been reported previously (Easton & Fraser 1992).
The methods have been fully described previously (Easton & Fraser 1994a), and the following is a brief summary. The experiments were performed on Wistar rats of both sexes aged between 23 and 33 days within the guidlines given by The Animals (Scientific Proceedures) Act 1986. Anaesthesia was induced by intraperitoneal injection of 0.72 ml kg−1 urethane (25% w/v in 0.9% NaCl solution) and maintained where necessary with intravenous doses of 0.07 ml kg−1. At the end of the experiment the animal was killed with an overdose of anaesthetic, prior to decapitation. Body temperature was maintained at 37±1 °C, and tracheal cannulation and orthograde cannulation of the left common carotid artery were performed routinely. The animal was placed prone with the head in a small steriotaxic frame. A section of the frontoparietal bones on the left side, approximately 5 mm × 5 mm between the coronal and lambdoid sutures, was thinned with a dental drill and removed. The cerebral surface was exposed by cutting away the overlying meninges, which in these young rats leaves the pial microvessels devoid of any continuous kyer of overlying tissue (Butt et al. 1990). The rat was then placed on the modified stage of a microscope (ACM; Zeiss) and the exposed cerebral surface illuminated with a 50 W mercury vapour lamp through a × 20 objective lens (NA 0.5; Cooke) fitted with a water immersion cap to eliminate the air–water meniscus. The surface of the brain was constantly superfused by a pump at the rate of 1–2 ml min−1 with artificial cerebrospinal fluid (CSF) warmed to 37±1 °C and delivered through a fine plastic tube attached to the side of the water immersion cap.
Measurements were made by introducing the fluorescent dye Lucifer Yellow (457 kDa, dilithium salt, 5 mM in 0.9% NaCl) into the cerebral microcirculation by bolus injections of between 50 and 200 μl in the ipsilateral carotid artery. A venular capillary with a straight unbranching section of 200–400 μm was selected, and a glass occluding probe (10–30 μm diameter) was lowered to trap the dye as it passed through the vessel, so forming an occluded segment. The microscope image was passed via an image intensifier camera (Panasonic WV-1900, Japan), a video-timer (For-A, Japan) through a video-densitometer and displayed on a television monitor. The video-densitometer operated by integrating the video signal between variable electronic gates used to create a bright cursor on the television monitor. The cursor was placed over a section of the vessel at least 30 μm from the occluding probe, where the vessel would not suffer from geometric distortion (Easton & Fraser 1994a), and at least 100 μm from the open end. The fluorescence was proportional to the concentration of dye and the level of illumination was such that there was no significant photolysis (Fraser & Dallas, 1990). The light signal in the region defined by the cursor was relayed by the video-densitometer to a chart recorder (Lectromed M19, Welwyn Garden City, UK). The axial concentration profile of an occluded microvessel was determined from images captured in an image processor (DIS 3000; Digital Imaging Systems, Newport, UK) and measurement of the fluorescence intensity along the length of the vessel using the Inspector image processor (Matrox; Denval, Quebec, Canada).
Permeability was calculated from the rate of decrease in fluorescence from the measured portion of the occluded segment. The rate at which the intravascular concentration of a small polar molecule, such as Lucifer Yellow, decreases is independent of the hydrostatic pressure (Fraser & Dallas, 1993). Thus the concentration of dye early in the occlusion, before axial volume flux distorts the uniform axial concentration of dye in the region of measurement, will be:
- (1)
where Ct and Co are the concentrations at times t and o, and k is 4P/d, with P representing the permeability and d the diameter of the vessel.
Solutions and chemicals
Lucifer Yellow (CH, dilithium salt) and urethane were obtained from Sigma. Artificial CSF was buffered to pH 7.40 ± 0.05 and contained (mm): NaCl, 110.5; KC1, 4.7; CaCl2, 1.25; KH2 PO4, 1.1; MgSO4.7H2O, 1.25; NaHCO3, 25; and Hepes, 15. These chemicals were from BDH Chemicals (Poole, UK) except MgSO4.7H20 which was from Fisons (Loughborough, UK) and Hepes which was from Sigma. Histamine (free base), isoprenaline (dl form, bitartrate salt), catalase and dibutyryl cyclic AMP (monosodium salt) were from Sigma. Human α-calcitonin gene-related peptide (CGRP) was kindly given by Dr Susan Brain of King's College London. A23187 was from Sigma and was dissolved in dimethyl sulphoxide (DMSO) and diluted to give a 10 μm solution. Arachidonic acid (sodium salt; Cascade Biochem., Reading, UK) was stored in ethanol at −20 °C. Aliquots of this were gassed with nitrogen to remove the ethanol, and the residue was dissolved in 100 mm sodium carbonate, which was diluted to the required concentration in artificial CSF.
Drugs were applied on the brain side of the microvessels either by dissolving them in the superfusing solution, or focally through a micropipette with a 3 μm diameter tip placed between 2 and 5 μm from the abluminal wall. In the latter case a trace of the fluorescent dye sulforhodamine B (Aldrich, Gillingham, Dorset) was included in the pipette so that the distribution and relative concentration of the drug could be seen easily by changing to the appropriate filter set. Measurements of permeability were made over a period of at least 30 s and started within 30 s of a drug being applied or removed.
There was sufficient autofluorescence in the fluorescein filter set for the cerebral surface to be viewed directly under the microscope. The long, straight arteries and arterioles were easily distinguished from the venular capillaries which were shorter and more tortuous. A venular capillary with an unbranching section of at least 200 μm was selected and the glass occluding probe positioned at one end of the vessel. A bolus of fluorescent dye-containing solution was injected through the carotid arterial cannula, and during its transit through the microcirculation the arterioles filled rapidly, and the venular capillaries filled later. The occluding probe was lowered on to the venular capillary, thereby forming a segment containing dye, while dye was cleared from the rest of the microcirculation.
The rate of change in dye concentration for a small molecule such as Lucifer Yellow will depend on diffusion both axially to the open end of the occluded segment, and radially across the endothelium when a permeable pathway is present (Fraser & Dallas, 1993). Our previous observations on leaky cerebral microvessels showed that radial diffusion was much more important than that along the vessel axis. Thus the rate of concentration decrease showed no change when one probe of a doubly occluded venular capillary was removed (Easton & Eraser, 1994a). This was further investigated here since a number of the following experiments concern microvessels with much lower permeabilities than those reported on previously, and hence it would be expected that axial diffusion would be relatively more important. Measurements of the fluorescence along the axis of a microvessel that showed no sign of transmural diffusion (i.e. an intact blood-brain barrier) were made during a single occlusion. This profile was compared with that calculated from the equation CtC0= erf{x/(2√DT)}, where C is the concentration (at times t and 0), erf is the error function, x is the distance from the open end, D the diffusion coefficient for Lucifer Yellow (taken as 5 × 10−6 cm s−2) and T the time from the beginning of the occlusion (see Crank, 1956). The boundary conditions are that: (i) concentration at the capillary entrance is held at zero, (ii) there is no diffusion across the capillary wall, and (iii) the capillary is infinitely long. In an occluded capillary this last condition is broken, and this will result in the dye concentration being overestimated. Fluorescence profiles were measured on images captured shortly after the occlusion started, and 33 s later. The theoretical curve was fitted to the earlier profile by adjusting the variable T, and the second curve was generated from the fitted T value + 33 s. Figure 1B shows that this second curve grossly underestimates the dye remaining in the bulk of the capillary, although the fit is reasonably good close to the open end. It is possible that a few cells, trapped in the microvessel in the dye–blood mixture, effectively produced short lengths of vessel in which the cross-sectional area available for axial diffusion along was reduced. Under these circumstances Lucifer Yellow concentration changes more than 100μm from the open entrance will be largely governed by diffusion across the wall. Later during the same occlusion when this vessel became leaky, the axial fluorescence profile remained flat in this region, and well above the predicted value for unhindered diffusion to the open end.
Permeability changes with time
Generally, the rate of fall in fluorescence was very low in occlusions carried out shortly after the exposure of the cerebral surface. This rate was so low that it could not really be distinguished from the random oscillations in the signal. Permeability to Lucifer Yellow (Ply) was measured in five single cerebral venular capillaries (diameter range, 14.5–27 μm) in five rats at frequent intervals from 2 to over 5h (Fig. 2). Permeability was initially very low, and corresponds to the tight state of the intact blood-brain barrier. Permeability later rose in two distinct phases, the first of which occurred between 20 and 54min after the exposure of the pial surface and lasted for between 44 and 164min. It was characterized by a relatively stable, low permeability to Lucifer Yellow, about one-tenth of that found in skeletal muscle capillaries (Ply= (1.65±0–603) × 10−6 cm s−1; mean ± S.D., 38 measurements in the 5 vessels). This first phase was considered to have finished, and the second to have started, when Ply increased abruptly to over 5 × 10−6 cm s−1 and fluctuated thereafter.
Raised and fluctuating permeability was a feature of the second phase of increase: Ply was (12.31±15.14) × 10−6cms−1 (mean±S.D. of 135 measurements in the 5 vessels). There was no discernible pattern in these fluctuations and they were sometimes so rapid that it was possible to detect several different rates of dye loss during a single occlusion (Fig. 3A The onset of this second phase of permeability increase could be prevented for over 4 h by including the hydrogen peroxide scavenger catalase (100 U ml−1) in the superfusing solution: this was examined in four rats and Fig. 3A shows one of these.
Mimicking and reversing the first phase of disruption
Raised intracellular [Ca2+] has often been implicated in increased permeability of microvessels generally, and particularly in reducing the trans-pial microvascular electrical resistance in frogs (Olesen, 1987). This was tested on the present preparation by applying the divalent cation ionophore A23187 (10 μm; dissolved in DMSO which had not effect on fluorescence) on to the occluded microvessel through a 3 μm diameter micropipette applied closely to the abluminal surface. Ply increased reversibly in the presence of calcium in the superfusing medium, but not at all when the calcium concentration was nominally zero. The degree of Ply increase did not change when the calcium concentration was increased from 2 to 10 mm (see Fig. 4).
Addition of histamine (10 μm) to the solution that superfused the brain surface resulted in previously 'tight' microvessels becoming permeable at levels similar to those found in the first phase of spontaneous disruption, i.e. Plyincreased from (0.13 ± 0.03) × 10−6 to (2.12±0.23) × 10−6 cms−1 (4 vessels from 4 rats; P < 0.001). This increase in permeability was reversible, (see Fig. 5). Previous reports have indicated that the response to histamine in these vessels is mediated via the H2 and not the H1 receptor. We examined this by carrying out a series of experiments (see Fig. 6) using 0.5 μm histamine in combination with either the H2 antagonist cimetidine or the H1 antagonist mepyramine, and our results confirmed that it is the H2 receptor and not the H1 receptor that is responsible for the permeability increase.
It has been reported that the permeability (measured by transendothelial resistance) of cultured cerebral endothelial monolayers decreases when intracellular cyclic AMP levels are raised (Rubin et al. 1991). This was investigated here by measuring changes in Ply in microvessels that had been exposed sufficiently long for them to be in the first phase of spontaneous increase. Each of the following substances were applied to four vessels with diameters ranging between 12 and 27 μm from four rats. Dibutyryl-cAMP (250 μm) was added to the superfusate and reduced Ply from (0.79±0.02) × 10−6 to (0.01 plusmn; 0.01) × 10−6 cm s−1, (P 0.05, paired t test). Similar effects were obtained with isoprenaline (5 μm) and CGRP (50 pm) where Ply fell from (2.20± 0.02) × 10−6 to (0.20±0.02) × 10−6 cms−1, (P 0.025), and from (2.25±0.56) × 10−6 to (0.16±0.01) x10−6 cm s−1, (P 0.025), respectively. Figure 7 summarizes the results obtained in these experiments.
The second phase of disruption
Since attempts to mimic the second phase of disruption by procedures that were designed to raise [Ca2+]1 failed (see above), other mediators are likely to be involved. Disruption of the blood-brain barrier underlies the development of vasogenic cerebral oedema, and patients with this condition have been shown to have very high levels of arachidonic acid in cerebrospinal fluid (Chan & Fishman, 1984). It seems possible that this fatty acid has a direct effect on cerebro-microvascular permeability (Onishi, Posner & Shapiro, 1992). We examined this by applying 1 mM arachidonic acid focally through a micropipette to occluded microvessels. Mean Ply rose after the addition of arachidonic acid from (1.97 ± 0.317) x10−6 to (13.7 ± 1.98) ± 10−6 cms−1 (7 vessels from 5 rats, P < 0.001), and this effect was fully reversed within 2 min on all occasions. The largest rise in Ply was from 1.35x10−6 to 23.73x10−6 cm s−1. Sometimes rapid changes in permeability were also seen in the course of an occlusion, and when this occurred the first value was reported. Oleic acid (2 him) had no effect on permeability: Ply was (1.73±0.61) × 10−6cms−1 before and (1.71±0.50) × 10−6 cm s−1 during application in four vessels from four rats. These findings are summarized in Fig. 8.
It has been suggested that polyamine synthesis is an important factor in the disruption of the blood-brain barrier (Koenig, Goldstone & Lu, 1989), and it is possible that this will result in raised pH1. In our search for mechanisms of mimicking the second phase of disruption we applied an isosmotic superfusate in which NH4C1 (50 mM) substituted for NaCl and the pH buffered to 7.4. Rapid transient rises in Ply were seen in four microvessels from four rats, similar to the second-phase spontaneous permeability increase: Ply rose to peak values of 22.4 × 10−6, 37.2 × 10−6, 41.9 × 10−6 and 13.8 × 10−6 cm s−. These results are illustrated in Fig. 9.
These experiments show that there is a qualitative difference in the types of permeability increase in pial microvessels. These vessels are part of the blood-brain barrier and initially have a very low permeability, but following the removal of a relatively large area of meninges their permeability increased spontaneously in two distinct phases, despite the continuous superfusion of an artificial cerebrospinal fluid. Immediately after meningeal removal the vessels were tight, but after a few minutes there was a small permeability increase which could be mimicked by procedures that were calculated to raise endothelial [Ca2]1 After about an hour there were large fluctuating increases, some aspects of which could be imitated by the application of arachidonic acid or ammonium chloride. The observation that a 5-fold increase in [Ca2+]i in the presence of A23187 caused no greater increase in permeability is an indication that separate mechanisms are involved in the two phases of spontaneous permeability increase, and that the second phase is not a mere extension of the events of the first. We have carried out some experiments to ascertain the mechanism by which arachidonic acid mediates this large permeability increase (Easton & Eraser, 1994b) and it appears that oxygen free radicals are necessary. This contention is supported by the present finding that the second phase of permeability increase could be prevented with catalase.
The rapid changes in the rate at which fluorescent signal decreases during the second phase could possibly have been brought about by an undetected slippage of dye past the occluding probe, or by a loss and replacement of vascular cells at the capillary entrance. We do not consider that either these mechanisms played an important role. Firstly, there were occlusions in which more than one rate of dye loss was observed (see Fig. 3A) while the vessel was blocked at both ends by occluding probes. Secondly, when an occlusion did slip so that there was an obvious movement of cells within the vessel, dye concentration did fall, but at a rate rather lower than was seen in rapid transient high permeability measurements.
The idea that there are two sequential phases of disruption has not been reported before, and this is likely to reflect the greater sensitivity and spatial resolution of the method used here. Some aspects of the technique will be discussed before the present findings are related to other studies that have examined disruption of the blood-brain barrier.
Comparison with other single cerebral microvessel measurements
The advantage of single vessel techniques is that they can separate diffusional permeability from complications resulting from connective transport. There are a number of reports on permeability changes using the electrical resistance method in pial microvessels. There are, however, additional advantages in resolving higher permeabilities with the micro-occlusion technique due to its greater spatial resolution.
Normal blood-brain barrier
The lower limit of the permeability measurement in the present experiments depends upon the resolution of the rate of fall of fluorescence. This was about 3 % of the signal over the course of a minute, so for a 15 /tm diameter microvessel this is equivalent to a permeability to Lucifer Yellow (Ply) of slightly under 0.2 × 10−6 cm s−1. This may be compared with permeability estimates made from the maximum electrical resistance measurements on single cerebral microvessels, since P = Dp/R, where p/R is the ratio of the resistivity of mammalian extracellular fluid to the resistance measurement. These values of R range between 1500 and 3000 Q, cm2 (Butt & Jones, 1992), and taking D and p to be 5 × 10−6cms−2 and 60 × 2 cm, respectively, giving a PLY range of 0.2 × 10−6 to 0.1 × 10−6 cm s−1. This agrees with measures of sucrose permeability across the blood-brain barrier of the rat frontal lobe using a whole organ technique (0.054 × 10−6 cm s−1; Takasato, Bapoport & Smith, 1984). This indicates that the low Ply values recorded within 30 min of removing the meninges are likely to be from normal tight vessels.
First phase of disruption
Published results show that stimuli that would be expected to raise [Ca2+]i and which result in permeability increases that correspond to the first phase of disruption, give values of similar order of magnitude with the electrical resistance method and the single occlusion technique (Olesen, 1987). The resistance values are somewhat lower, however, and this probably reflects the fact that permeability and resistance are inversely related. Hence simple averages of resistance will necessarily underestimate permeability. This also applies to the effects of hyperosmotic solutions: Fraser & Dallas (1990) calculated a sucrose permeability of 12 × 10−6 cms−1 in frog pial microvessels disrupted by hyperosmotic shock (equivalent to a resistance of 38 Q, cm2), which compares reasonably well with the mean resistance of 98 Ω cm2 in rat pial venules disrupted by hyperosmotic mannitol (Butt et al. 1990).
Second phase of disruption
In contrast, permeability increases with the occlusion method during the application of arachidonic acid, ammonium chloride and prolonged exposure of the cerebral surface were more than an order of magnitude greater than those reported with the resistance method. Many permeability changes have been shown to be confined to discrete sections of microvessels (e.g. Luthert, Greenwood, Pratt & Lantos, 1987), which we have confirmed by showing patchy permeability increases along the length of leaky pial microvessels (Fraser & Dallas, 1990). The measurement of resistance relies on cable theory, which requires a uniform voltage dissipation over the length of the microvessel (at least 200 /tm: Crone & Olesen, 1982). This will distort the sampling of data because leaky vessels with a patchy permeability would have to be discarded (Butt et al. 1990). The microvessel occlusion technique, however, allows patchy permeability to be resolved to within 10 μm, and can measure the changes to within 10s. The electrical method can, in some instances (Crone & Olesen, 1982), give changes in measurements to less than 1 s, although in at least one variation of the method data were gathered between a pair of electrodes 250 μm apart and averaged over 2–15 s to give mean resistance measures. It usually took 30–60 s for an occlusion measurement to be made, but transitions in permeability could be detected more rapidly, so long as they occurred within the course of an occlusion (see Figs 3 A and 7A). These rapid transitions in permeability were not reported with the resistance method, probably because the changes were confined to only a small segment of the total measured length.
Whole brain studies
The majority of studies of barrier disruption have used whole brain techniques which produce measures of the number of leaky sites of dye extravasation, and quantitative changes in permeability–surface area product (PS) to radioisotopes. Techniques that depend upon macromolecular escape will probably be complicated by convective effects brought about by changes in intravascular pressure as well as in the area available for diffusion across the vessel wall (Schilling & Wahl, 1994). Increased cerebral venous hydrostatic pressure, however, can itself result in disruption of the blood-brain barrier (Häggendal & Johansson, 1972), a complication that was avoided in the present study by applying substances focally. Some studies, in which cerebro-vascular PS increases were quantified, have shown significant differences depending on the stimulus used. Thus, infusion of 10 μm histamine in the rat resulted in a 2–3 times permeability increase to [14C]sucrose and amino-isobutyric acid (Gross et al. 1982), topical application of 600 μm arachidonic acid gave about a 5-fold increase in albumin permeability (Kontos et al. 1985), while 20-fold increases in sucrose permeability after infusion of hyper-osmolar arabinose were found by Rapoport et al. (1980). The permeability values from these stimuli are somewhat lower than those from micro-occlusion measurements (e.g. 2 × 10−6 cm s−1 compared with 12 × 10−6 cm s−1; Rapoport et al. 1980 cf. Fraser & Dallas, 1990, assuming a micro-vascular surface area of 100 cm2 g−1), but this is consistent with the patchy disruption of the microvessels observed in these capillaries. Gross et al. (1982) found the regional permeability to sucrose during continuous histamine infusion was equivalent to 0.2 × 10−6 cm s−1, which is rather less than the 2.0 × 10−6cm s−1 measured in the present studies. These differences could be explained by histamine degradation by leucocytes or endothelial ecto-enzymes (Plaut & Lichtenstein, 1978), but it is also possible that the pial venular capillaries are rather more responsive to inflammatory mediators than other pial microvessels (Butt et al. 1990), or parenchymal vessels (see Gross et al. 1982).
The increased sensitivity and resolution given by the single microvessel occlusion technique has allowed us to resolve three distinct ranges of permeability that occur in individual pial venular capillaries as they pass from the intact blood-brain barrier and become inflamed. The results presented here suggest that the first phase of spontaneous increase is an early step in inflammation consequent on removing the meninges. There are many inflammatory mediators which raise endothelial [Ca2+]i and also increase permeability, and histamine is one such example. This permeability increase is limited in these brain venular capillaries and is not sufficiently great to lead to cerebral oedema. The much larger increase seen in the second phase was probably due to generation of free radicals, since its spontaneous development could be prevented by catalase. Permeability decreases could be brought about by the application of substances that raise intracellular cAMP concentration, a phenomenon also found in many other vascular beds. These observations point towards there being controlled increases in cerebrovascular permeability, which may fulfill physiological functions, as well as the much larger permeability increases, which are probably pathological.
- 1992). Effect of histamine and antagonists on electrical resistance across the blood-brain barrier in rat brain-surface microvessels. Brain Research 569, 100–105. & (
- 1990). Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. Journal of Physiology 429, 47–62. , & (
- 1984). The role of arachidonic acid in vasogenic brain edema. Federation Proceedings 43, 210–213. & (
- 1956). The Mathematics of Diffusion. Oxford University Press, London . (
- 1982). Electrical resistance of brain microvascular endothelium. Brain Research 241, 49–55. & (
- 1992). Two phases of blood–brain barrier disruption in single cerebral microvessels of the anaesthetized rat. Journal of Physiology 446, 503P. & (
- 1994a). Variable restriction of albumin diffusion across inflamed cerebral microvessels. Journal of Physiology 475, 147–157. &. (
- 1994b). Evidence that arachidonic acid disruption of the blood–brain barrier is mediated by free radicals in the anaesthetized rat. Journal of Physiology 475.P, 71P . &. (
- 1990). Measurement of filtration coefficient in single cerebral microvessels of the frog. Journal of Physiology 423, 343–361. & (
- 1993). Permeability of disrupted cerebral microvessels in the frog. Journal of Physiology 461, 619–632. & (
- 1992). Blood–brain glucose transfer. In Physiology and Pharmacology of the Blood–Brain Barrier, ed. Bradbury, M. W. B. Handbook of Experimental Pharmacology , vol. 103, pp. 65–115. Springer, Berlin . (
- 1992). Experimental manipulation of blood–brain and blood–retinal barriers. In Physiology and Pharmacology of the Blood–Brain Barrier, ed. Bradbury, M. W. B., Handbook of Experimental Pharmacology , vol. 103, pp. 459–486. Springer, Berlin . (
- 1982). Intra-arterial histamine increases blood–brain transport in rats. American Journal of Physiology 243, H307–317. , , , & (
- 1972). On the pathophysiology of the increased cerebrovascular permeability in acute arterial hypertension in cats. Acta Neurologica Scandinavica 48, 265–270. & (
- 1989). Polyamines mediate the reversible opening of the blood-brain barrier by the intracarotid infusion of hyperosmolal mannitol. Brain Research 483, 110–116. , & (
- 1985). Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats. Circulation Research 57, 142–151. , , , , , & (
- 1987). The effect of a metabolic inhibitor on the properties of the cerebral vasculature during a whole-head saline perfusion of the rat. Quarterly Journal of Experimental Physiology 72, 129–141. , , & (
- 1987). Regulation of ion permeability in frog brain venules. Significance of calcium, cyclic nucleotides and protein kinase C. Journal of Physiology 387, 59–68. (
- 1986). Substances that rapidly augment ionic conductance of endothelium in cerebral venules. Acta Physiologica Scandinavica 127, 233–241. & (
- 1992). Vasogenic brain edema induced by arachidonic acid – role of extracellular arachidonic-acid in blood–brain-barrier dysfunction. Neurosurgery 30, 545–551. , , (
- 1978). Histamine, 5-hydroxy-tryptamine, SRA-A: discussion of type I hypersensitivity (anaphylaxis). In Inflammation, ed. Vane, J. A. & Ferriera, S. H., Handbook of Experimental Pharmacology , vol. 50, pp. 344–373. Springer, Berlin . & (
- 1980). Quantitative aspects of reversible osmotic opening of the blood–brain barrier. American Journal of Physiology 238, R421–431. , , & (
- 1987). Size selectivity of blood-brain barrier permeability at various times after osmotic opening. American Journal of Physiology 253, R459–466. & (
- 1991). A cell culture model of the blood-brain barrier. Journal of Cell Biology 115, 1725–1735. , , , , , , , , , , , & (
- 1994). Opening of the blood-brain barrier during cortical superfusion with histamine. Brain Research 653, 289–296. & (
- 1984). An in situ brain perfusion technique to study cerebrovascular transport in the rat. American Journal of Physiology 247, H484–493. , & (
A. S. E. was supported by an MRC–Pfizer Collaborative studentship, and M.H. S. was a Commonwealth Staff Scholar.


text:
Showing 1-1 of 1 Microbiologist - Part Time job
Part Time Microbiologist
Srl - Agartala , Tripura
Desired Candidate ProfileEducation- UG: MBBS - MedicinePG:M.S/M.D - Any Specialization, MicrobiologyDoctorate:Any Doctorate - Any Specialization, Doctorate Not ...
from Recruit.net
Sign Up for Job Alerts
We will send job alerts to for Microbiologist - Part Time jobs.
To activate your job alert, please check your email and click the confirmation button.
We weren't able to create your email alert. Please check that the email address you entered is valid, and try entering your information again.
Your Recent Searches
Featured Jobs
We have saved your search for Microbiologist - Part Time job.
You can manage your saved searches at any time from your profile.


text:
|Name: _________________________
|Period: ___________________
This quiz consists of 5 multiple choice and 5 short answer questions through Chapter 22, The Power of Aumamay.
Multiple Choice Questions
1. What vision does Aham have which convinces the Sawi villagers that there is no hope for Warahai?
(a) A vision of a great tall Walahari bird which tells her to let go of Warahai.
(b) A vision of Warahai speaking to her from the other side.
(c) A vision of a spirit which ambushes Warahai's soul and eats it.
(d) A vision of a spirit flock which cover the village as they fly over.
2. Where are dead bodies interred in a Sawi village?
(a) They are sunk in the Kronkel river just downstream of the village.
(b) In a small, coffin-sized gravehouse, elevated five to fifteen feet above ground.
(c) Deep in the earth, directly under the family longhouse.
(d) In a communal grave, on the edge of the village.
3. What does Richardson feel when he first shakes hands with a Sawi elder?
(a) That they are equally human...flesh and blood...men.
(b) That the Sawi are very short but quite strong.
(c) That the Sawi will never understand the way of the modern world.
(d) That these people are not to be trusted...ever...
4. What is Carol Richardson feeling as she steps onto the bank of her new home?
(a) Carol is planning her escape.
(b) Carol is very angry with her husband.
(c) Carol is hysterical with weeping.
(d) Carol is excited and awed.
5. What is the name of the sea which the Kronkel river empties into?
(a) The Atlantic Ocean.
(b) The Arafura Sea.
(c) The Agrabar Waterway.
(d) The Agramenon Basin.
Short Answer Questions
1. How does Mavo respond to the protection and kindness which Richardson shows to him?
2. What brings the Sawi villagers to a sudden halt when they hear it for the first time?
3. What is the most powerful family relationship in Sawi culture?
4. Who comes in a dugout to help the stranded party?
5. Why is Yae going on a journey to the nearby village of Haenam?
This section contains 451 words
(approx. 2 pages at 300 words per page)


text:
Deltron 3030
The self-titled, sci-fi-infused concept album born of the collaboration of Del Tha Funky Homosapien, Dan the Automator and Kid Koala way back in the year 2000 has maintained a devout, cult-like following of hip-hop heads. With Del unraveling tales of intergalactic rap battles atop some of Automator's most distinctive production work, the futuristic allegory has aged better than all but the most classic of hip-hop records. A dozen years later, the three — who never toured together for the album's original release — are hitting the road, performing a mix of tunes from the original as well as new material from a forthcoming sequel. Denver is one of only a handful of cities across the country to score a tour stop, so if you miss this show, it could be another decade before you have the chance to see them again.
Related Location
2637 Welton St.
Denver, CO 80205
Get the Music Newsletter
Keep your thumb on the local music scene each week with music news, trends, artist interviews and concert listings. We'll also send you special ticket offers and music deals.
Sponsor Content
More Music News
- Quantum Creep Keeps Rolling With the Punches
Upcoming Events
Ely Young BandFri., Jul. 31, 8:30pm
Sabrina Carpenter - Meet & Greet UpgradesSat., Aug. 1, 7:01pm
RetractSat., Aug. 1, 8:00pm
The Spill CanvasTue., Aug. 4, 7:00pm
- Tickets
- David J on Bauhaus and His Unexpected Bob Dylan Fandom
- Vomitstep Is a Thing Now, Thanks to DJ Snails


text:
I Know That Girl pussy-fingering VIDEOS (10)
After Kimmy Granger's dad puts an end to her striptease, she has to redo it as a live show for her BF. She takes off her slutty schoolgirl outfit, shakes her titties, straddles her man's fat dick, and rides him with her tight teen pussy.
I Know That Girl
95 %
114025 views - Jun 01, 2015
When Jojo Kiss made her fuck buddy chase her out to the pool where she wrapped her pussy lips around his long strong dong and rode him like there's no tomorrow, she showed him that the morning after can be just as wild as the night before.
I Know That Girl
95 %
97897 views - Jul 09, 2015
Sydney tells her BF she'll do anything for a cupcake, and what her BF wants is to make a steamy sex tape with his hot GF. It turns out she's more eager than he thought. She sucks his cock, fucks his dick dry with her wet pussy, then drinks his cum.
I Know That Girl
94 %
120743 views - Mar 23, 2015
Last time they fucked outside the neighbor saw, but that doesn't stop Blair Summers and her BF from getting down and dirty in the backyard. After being spotted, this hot mixed-race brunette runs to the sauna and gets fucked face down ass up.
I Know That Girl
94 %
77874 views - Jul 02, 2015
However this genius managed to twist pranking his girlfriend into filming a their own sex tape. Once Kaylee caught the joke, she started teasing him with peeks at her perfect tits. Then she gave him a deepthroat blowjob on camera, and fucked him too!
I Know That Girl
93 %
96159 views - Feb 16, 2015
Kenzie Taylor's boyfriend wouldn't stop recording her with his new camera, but when he started filming himself rubbing oil on her juicy ass, it made her so damn horny that she had to head inside, whip out his dick, and take it deep in her wet pussy!
I Know That Girl
93 %
85248 views - Mar 30, 2015
Kitana wants the perfect sexy panties for her night on the town. As she tries on pair after pair, her bf can't help but whip out his fat cock and plunge it into her horny mouth, wet pussy, and tight asshole, making her gape wide and squirt hard.
I Know That Girl
92 %
107563 views - Apr 13, 2015
To reward her man for getting promoted, Samantha filmed herself stripping down and filming a private webcam video to tease him on the job. When her man raced home from his gig, Samantha was there waiting with a wet pussy and a horny appetite to fuck!
I Know That Girl
91 %
70936 views - Mar 09, 2015
Bianca Brill got some sexy lingerie for Xmas, so to thank her man she stripped down and let him eat her tight pussy until his cock was rock hard. She gave him an amazing blowjob, rode his dick, and then took a load of jizz all over her pretty face!
I Know That Girl
87 %
72678 views - Jan 05, 2015
One lucky guy gets to film his sexy teen girlfriend, Cleo Vixen, rub her clit with her special toy, and when she's finished, the fortunate guy gets to pinch her tender nipples, grab her small tits, and plunge his big hard cock into her wet pussy.
I Know That Girl
82 %
44679 views - Jul 16, 2015


text:
KPMG has been recognised for forward-thinking leadership and exceptional commitment to client support.
What start-ups need to consider? Where to get access to information? What events they can consider to attend?
2014 FinanceAsia Achievement Awards
IT Infrastructure Development Award 2014 from CICPA
more awards
This page provides direct access to the series of materials available on the new revenue standard designed to assist companies with the transition to IFRS 15.
This section is dedicated to special topics and interests. Each of these discrete sections presents research, opinion and KPMG thought leadership.
China's banking sector: Performance of listed banks and hot topics in 2015 Q1
The report analyses the financial position and business performance of listed banks for the first quarter of 2015. The report also focuses on current hot topics, including interest rate liberalisation, and how the wealth management business in banks has returned to a focus on asset management. We also invited finance academics to share their insights on better strategic coordination between RMB internationalisation and foreign currency reserve, which are interrelated.
Global Manufacturing Outlook 2015: Preparing for battle - Manufacturers get ready for transformation
The report is based on a survey of 386 senior executives conducted by Forbes on behalf of KPMG International completed in early 2015. Respondents represented six industries: Aerospace and Defense, Automotive, Conglomerates, Life Sciences - Medical Devices, Engineering and Industrial Products and Metals. Fifty percent of respondents held C-level positions and a third represented organizations with more than US$5 billion in annual revenue.
The Rapidly Changing Face of D-Commerce
Shanghai Pilot Free Trade Zone Series
CFO Agenda
China's 12th Five-Year Plan - Insight Series
Three of the main priorities in this Five-Year Plan are sustainable growth, industrial upgrading and the promotion of domestic consumption.
China's urban future
Board Advisory
China's Fourth Plenum - Implications for business
KPMG's Global China Practice provides a short analysis of this Plenum. We put this meeting into context, and summarize the key outcomes. In particular we have provided our view on the potential impact to business in China as a result of some of the changes put forward in the Plenum.
© 2015
KPMG Advisory (China) Limited, a wholly foreign owned enterprise in China and KPMG Huazhen LLP, a People's Republic of China partnership, are member firms of the KPMG network of independent member firms affiliated with KPMG International Cooperative ("KPMG International"), a Swiss entity. All rights reserved.
© 2015 KPMG, a Hong Kong partnership and a member firm of the KPMG network of independent member firms affiliated with KPMG International Cooperative ("KPMG International"), a Swiss entity. All rights reserved.
The KPMG name, logo and "cutting through complexity" are registered trademarks or trademarks of KPMG International.
KPMG International Cooperative ("KPMG International") is a Swiss entity. Member firms of the KPMG network of independent firms are affiliated with KPMG International. KPMG International provides no client services. No member firm has any authority to obligate or bind KPMG International or any other member firm vis-à-vis third parties, nor does KPMG International have any such authority to obligate or bind any member firm.


text:
Feb. 3, 2005 -- Better than expected fourth quarter results have helped venture capital firms stoke their fundraising furnaces for the third year in a row, according to a new study by Thomson Venture Economics and the National Venture Capital Association. In fact, the $17.6 billion that 170 funds raised last year was an impressive $3.4 billion more than the total funds raised over the last two years combined.
Even more outstanding results were reported in the buyout and mezzanine fund arena: the $45.8 billion raised by 103 funds marks the highest level of private equity commitments since the year 2000. A reported 34 funds raised over $13 billion in the fourth quarter alone.
The news gives further hope to an industry still struggling to recover from its pre-crash high-water mark in 2000 where a total of almost 800 VC, buyout and mezzanine funds raised over $180 billion to help feed the dot-com economy.
"We expect the quarterly increases in venture capital commitments to continue into the first half of 2005," said Mark Heeson, president of the NVCA. "Many established firms are still out there fundraising successfully. But as an asset class, we should be looking for an eventual leveling off this year so that we do not raise more money than the industry can support."
One hungry area that the industry has retrained its fundraising strength on is emerging companies, where VCs poured $21 billion in 2004. That figure marks the first increase in new company funding on over three years, according to the MoneyTree survey published jointly by Thomson, the NVCA and PricewaterhouseCoopers.
6 Colors That Boost Creativity, Happiness, and Productivity in the Office
6 Polarizing Differences Between Managers and Leaders
4 Tools to Help Maximize Your Sales Leads
6 Colors That Boost Creativity, Happiness, and Productivity in the Office
This Hilarious TED Talk Demonstrates Every Bad Meeting You've Ever Attended


text:
Higher cure rates and fewer long-term effects from treatment are just two of the benefits teenagers and young adults up to age 21 receive when their cancer is treated at pediatric medical centers.
Mary Elizabeth Sierra-Lanham, 14, chatting with social worker Tonya Ranchigoda, says she appreciates staff members' ability to relate to teens.
When Mary Elizabeth Sierra-Lanham had her eyes checked for nearsightedness, the routine exam showed that the optic nerve in her right eye was swollen. A string of visits to different specialists led to an MRI that finally explained the problem – a lump in her head was pressing against a major vein.
That was when mom Sally Lanham brought Mary Elizabeth to Seattle Children's, where blood and bone marrow samples confirmed that her daughter had acute lymphoblastic leukemia (ALL), a type of cancer where malignant white blood cells or "lymphoblasts" are overproduced in the bone marrow and can spread into the bloodstream and vital organs. ALL accounts for approximately 25% of all childhood cancer.Although Lanham didn't know it when she switched Mary Elizabeth's care to Seattle Children's, her decision may have saved her daughter's life: Teenagers and young adults have a much better chance of beating ALL – more than 25% better – when they receive pediatric cancer treatments rather than those intended for adults. Separate studies in North America, France, the Netherlands and Italy confirm these findings.
"We've learned from years of research that teenagers have far fewer relapses when their treatment is longer and more aggressive than the less rigorous treatment that middle-agers and seniors receive," says pediatric oncologist Dr. Doug Hawkins.
"Yet, we still see medical oncologists out in the community treating 15-to-21-year-olds with less effective protocols that are sometimes decades out of date."
At Children's, teens and young adults with cancer not only benefit from cancer treatments developed specifically for their age group, they also thrive in an environment where teams of skilled providers focus on their long-term health concerns and the unique needs of their entire family.
Mary Elizabeth recalls the MRI technician who played music and chatted with her during her first procedure at Seattle Children's – the visit that confirmed her cancer diagnosis.
"I had an MRI at another hospital and it was scary," says Mary Elizabeth. "They left me alone and no one checked on me. At Seattle Children's, the staff tell stories and we laugh. I'll miss them when I'm done with treatment."
7.8.15 - The Stranger
Preventable diseases aren't supposed to be killing people in 2015. Yet the Washington State Department of Health recently...cont.
6.3.15 - The Seattle Times
A dye derived from scorpion venom that lights up cancer cells so surgeons can see — and remove — deadly brain tumors will be...cont.
6.1.15 - Infection Control Today
Group Health Research Institute conducted the first randomized trial to test an intervention aimed at improving hesitancy...cont.


text:
Hotel Concordia
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Minbar in room
- Continental Breakfast
- Drycleaning onsite
- Suites
- Restaurant
- Wireless internet connection in room (free)
Travelers also recommend:
TripAdvisor Reviews Hotel Concordia Livigno
Travel Blogs from Livigno
Relaxing in Silvaplana
Today we decided to spend the day chilling out before our planned return to Winkel where we would be meeting up with Justin who would be coming out to visit his Granny for a couple of days.
We spent most of the morning doing book work before going out for a brief ride ...
Walking the Italian zone.
... the normal conifers to deciduous forests with a lot of moss and ferns.
As we progressed the weather got hotter and hotter until we were really starting to need cooling down. We eventually came across a small mountain stream where we managed to find a reasonably comfortable picnic site. Here we ate whilst soaking our feet in the ice cold water.
Thus revived we set off on the ...
Milan (I) to Pontrecina (CH)
... he became too slow to balance the bike, stalled it and fell off. Neither he nor the bike were damaged, but it shattered what little confidence he had. I joined the main group and we continued on using our GPS to guide us, while the leader returned to collect our fallen rider. We headed south from the pass finally arriving at Pontresina at :7:30pm. We were all shattered after nearly 12 hours on the bike. After our evening meal it was an early night for us ...
Doing less than nothing well
At last a rest day. Today we did absolutely nothing apart from a 20 km round trip to St. Moritz to do some shopping. This is actually nothing these days. It was very hot so we did swim a bit in the lake. We also caught up on book work and spent some time doing ...
No rest for the wicked
Today, the blisters almost healed, we walked down to Surlej before heading uphill to Hannesee which is a small lake in the mountains above Chamfer. From here we followed the ridge along the side of the Corvatch until we eventually came down at Lej Staz near St. Moritz. Here we had a welcome swim as the weather was seriously warm before walking into St. Moritz and catching a bus home.
The walk took us through an area where many of the pine ...


text:
Welcome to Tacoma World!You are currently viewing as a guest! To get full-access, you need to register for a FREE account.
As a registered member, you'll be able to:
Quick Links: Scangauge II on sale at Amazon, $124.99 shipped 2D LED Maglite $15 - Free Shipping *gone* Amazon warehouse - rear Weathertech A-cab black - $22.82 / tan rear for $16.94 Westin Black Bull bars and nerf bars clearance at Amazon Weathertech In-channel Vent Visors on Sale at Amazon.com Curt Roof Mounted Cargo Basket
- Participate in all Tacoma discussion topics
- Communicate privately with other Tacoma owners from around the world
- Post your own photos in our Members Gallery
- Access all special features of the site
bfg a/t 32x11.5x15 $145ea.
Discussion in 'Deals & Coupons' started by magikbean562, Aug 31, 2011.


text:
Police plea for help finding accused child molester
Family says man might flee to Mexico
INDIANAPOLIS - Police are searching for a man accused of molesting a 7-year-old girl, and they think he might try to flee the country, officials announced Tuesday.
Luciano Pino, 42, is wanted on a charge of child molesting stemming from a July incident, Greenwood police said.
Pino's family told police they think he might try to flee to Mexico.
Pino is believed to be staying somewhere in the Indianapolis area.
Anyone with information is asked to contact the Greenwood Police Investigations Division at 317-887-5619 or your local police department.
Air ambulances called to serious crash on I-69
State police called in two air ambulances Saturday following a serious crash on Interstate 69 in Noblesville.
Mayor Ballard hosts 7th annual Peace Bowl
Mayor Greg Ballard joined more than 30 teams of kids, IMPD officers and community leaders for his 7 th annual Peace Bowl.
Man hopes for record with giant balloon octopus
A Michigan man is going for a world record at Gen Con: The planet's largest balloon sculpture.
ITW: Relief in sight for IPL, flooded farmers?
Will Indiana's waterlogged farmers receive aid from the federal government? Can Republicans successfully mount the defunding of Planned…
IMPD: Man hit multiple times in fatal shooting
Police were investigating a fatal shooting just west of downtown Saturday afternoon.


text:
deal over
deal over!
This family-owned company's name is inspired by the way it works -- covering every corner of each plumbing problem so nothing is overlooked. Opt for thoroughness with this crew:
• $89 ($216 value) for two hours of plumbing services
• Works with bath and kitchen fixtures, faucets, toilets, water heaters, and more
• Weekday appointments available
Four Corners Plumbing & HVAC's Website
PAID VALUE EXPIRES ON August 1, 2020
PROMOTIONAL VALUE EXPIRES ON July 16, 2014
service area
Service area includes a 40.0-mile radius from zip code 77090
Find out if you are eligible for service by entering your zip code below.
Buy this Deal with confidence, because it's covered by the LivingSocial Good Deal Guarantee up to the Voucher Expiration DateSee Details »
back by popular demand:
Four Corners Plumbing & HVAC
Two Hours of Plumbing Services
- from $89


text:
ProPublica analyzed the prescribing habits of 1.6 million practitioners nationwide and found that a tiny fraction of them are having an outsized impact on spending in Medicare's massive drug program.
Article ID:
Sheriff's office asks drug dealers to turn in their rivals
FRANKFORT, Ky. (AP) — A Kentucky sheriff's office has posted a flyer on its Facebook page asking drug dealers to turn in their rivals. Full Story
Toronto nightclub shooting leaves at least 2 dead, 3 wounded
TORONTO (AP) — A shooting that started at a Toronto nightclub and then spilled onto the streets outside early Tuesday left at least two people dead and three others wounded, police said. Full Story
Dr. Dre releasing first album in nearly 16 years
'Detox' is off but 'Compton: A Soundtrack,' inspired by the upcoming N.W.A. biopic 'Straight Outta Compton,' will be released on iTunes and Apple Music on Friday.