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I think social networking has a time and a place. I further believe there is a balance that has to be learned and also taught to others. As Shweta said, "'Hi' on someone's wall might be better than no phonecall for 1 year!" I think this is a great example of how Facebook and other social media types can be used in a positive way. I do feel though that there is a certain amount of introvertism that social sites can provide and sometimes gives us a false sense of security and hope. This is where "reality" should kick in and we should realize that there is a certain level of one-on-one interaction that is required to keep that healthy balance in life.
Someone is shy
Ted hasn't completed a profile. Should we look for some other people?
Comments & conversations
With technology advancing so fast and us now getting many books, publications, information electronically it's very surprising that publishers or eBook providers have not started to leverage the technology to draw readers in. I'm sure that interactive media will be the wave of the future, it's just going to take everyone some time to jump on board.


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The Village in NYC
The HOMOcidal Bomb
The Gay Basher
(~Elevated Bearhug/Flying Crotch Attack)
Bi Plex (Mace Mendoza)
Lick Chop (Buff E)
Feeling Up
Slither Pin
Da Hit Squad
Christopher Street Connection - OWW
The convention features live wrestling events, vendors, special guests, late night comedy, and wrestling game tournaments.
Former WWE writer addresses Hulk Hogan
WWE star's book selling very well
Ronda Rousey defends title, thanks WWE legend
"Mid-Atlantic Memories" debuts this weekend in Charlotte
This week's ClickWrestle Match of the Week is Cherry Bomb and Kimber Lee vs. Leva Bates and Veda Scott from April 12, 2014.
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Wrestling Geek Fest coming to Cleveland
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subset: commoncrawl


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text: comments Life A&E Life: Health & Fitness A&E: Books Oklahoma book signings Oklahoma book signings • Published: July 29, 2012 Advertisement BOOK SIGNINGS Full Circle Bookstore, 50 Penn Place Carolyn Wall will sign "Playing With Matches" at 3 p.m. Saturday. Compiled by Rick Rogers. Send book signing information to email@example.com. 0 0 Embed 0 Submit Letter Show Comments MORE FROM NEWSOK AROUND THE WEB 1 KFOR: Reports: Domestic shooting in northwest Oklahoma City 2 Crime on the decline in Tulsa Housing Authority housing complexes 3 Clinton aide may have 'delivered favors' for friends, IG finds 4 Reba McEntire and husband Narvel Blackstock announce separation 5 Firefighters battling north OKC apartment fire + show more FEATURED JOBS See All Ads


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At 75 ElevenRead MoreWhether you were in search of a new hat, scarf or pair of gloves, At 75 Eleven has got you covered. Try an item from At 75 Eleven; it's been known to make its wearers look amazing. Keep up with the current and hottest trends of this season with some new women's clothing items from here. At At 75 Eleven, you can find easy parking and multiple public transit stops. You'll be relieved to know that there's nearby parking available to At 75 Eleven.7511 Madison StreetForest Park, IL US
Painted Board StudioRead MoreLooking for a new date idea? Check out Painted Board Studio in Forest Park and enjoy a peaceful night of art browsing. Pick up a tasty meal at their restaurant, located conveniently within the museum. Commuters will love the easy access to public transit and parking close to Painted Board Studio. Parking is plentiful, so guests can feel free to bring their vehicles.7418 Madison StreetForest Park, IL US
American Artworks GalleryRead MoreTreat your eyes to some world-class art at Forest Park's American Artworks Gallery. Service and taste make a great restaurant, and that's why you won't be disappointed by this museum. Parking is plentiful, so visitors can feel free to bring their vehicles.7314 Madison StreetForest Park, IL US
Frank Lloyd Wright Preservation TrustRead MoreIf you want to gain insight into one of history's great architect, better check out his home. The first building over which Wright exerted complete artistic control was also his home for 20 years, and today it stands as a living archive of Wright's early experimentation. On guided tours, visitors can see plenty of examples of Wright's signature style, including his bold geometry and use of space, as well as several models and drawings.951 Chicago Ave.Oak Park, IL US


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Yippies Attack Pepsi Center with Peace Bats
Actually, there were only four Yippies -- one for every two journalists desperately trying to fill their DNC quota. The sixty or so younger activists who had also attended the "consulta" gathering of DNC protest groups at the Tivoli center earlier on Sunday wanted nothing to do with the Yippie nostalgia stunt involving large, inflatable "peace bats" and a guy dressed as a Chicago police officer.
For anyone who's managed to escape the 1968 retro-vision of the past two months, the Yippies were the merry band of pranking protesters led by Abbie Hoffman and Jerry Rubin, who added a tone of glee and silliness to the Chicago DNC protests.
The modern peace bat stunt wasn't exactly Pigasus for President, but it was still pretty entertaining in the end -- mostly because the clueless security crew manning the grounds of the Pepsi Center had no idea what to do with the bat-wielding Yippies as they posed on the walkway in front of the arena. One woman with a walkie-talkie told me that if I wasn't "with the protesters," then I had to step off the private property. Uh, yeah, that didn't happen.
Then another security guard yelled at me, saying I couldn't take photos toward the south, where the media tents were, even though I had taken dozens of pics of the structures a week before without harassment. Finally, as the Yippies pounded each other with the peace bats in front of the "Freedom Kage" fences of the demonstration area, a guy with a Secret Service badge emerged from somewhere and kicked us all out. At least I scored a free peace bat. --Jared Jacang Maher
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AmTech: Widescreen iPod with Bluetooth headphones in the pipelineApple Computer may release a new widescreen iPod with Bluetooth capabilities as early as its next fiscal quarter, analysts for American Technology Research said this week.
In a research note sent to clients early Tuesday morning, analyst Shaw Wu said his latest proprietary checks reveal that the new iMac Core Duo remains Apple\'s hottest selling PC.
Meanwhile, demand for the company\'s MacBook Pro professional notebooks continues to greatly outstrip supply, according to the analyst. However, he views recent improvements to the notebook\'s lead times to be a positive.
\"The most interesting development is that Apple has notified its distributors that its high-end 60GB vPod is \"at risk\" until the end of April, meaning it could be discontinued and/or replaced,\" Wu wrote. \"Timing is not certain to us, but we believe a new widescreen vPod with Bluetooth headphones could be ready as early as the June quarter.\"
The analyst also said his checks show sales of Apple\'s latest Intel Mac, the Mac mini, to be \"lukewarm, similar to the PowerPC versions it replaced.\" Wu said that despite the added features in the Intel version, there appears to be some hesitation among potential buyers due the price increase that accompanied the Intel Mac minis.
Looking at Apple\'s music space, Wu said checks show the iPod nano to be experiencing the greatest seasonal decline of all Apple\'s iPod models, with the exception of \"decent sales\" of the new low-end $149 1GB model. \"We believe Apple may need to increase storage capacities and/or cut prices to re-generate interest,\" he said. \"Declining prices in NAND flash and additional capacity coming on board should help Apple facilitate these moves.\"
American Technology Research made no changes to its March quarter estimates of $4.43 billion in revenue and 43 cents in earnings-per-share.
\"We continue to believe that consensus revenue and iPod unit forecasts may be unrealistically high,\" the firm said.
American Technology Research maintains a Buy rating on Apple shares with a price target of $101.
On Topic: General
- Tech shuttle drivers approve Teamsters contract, Apple working with contractors to raise pay
- This week on AppleInsider: Apple Watch at Best Buy, Apple Music numbers, Apple TV news & more
- IBM reportedly plans to purchase up to 200K MacBooks for employees
- Facebook completes first full-scale drone for spreading Internet access to remote regions
- AppleInsider podcast talks Apple Watch at Best Buy, rumored iPads, Steve Jobs movies & an Apple car


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Trust launch wireless home CCTV system
PRESS RELEASE: The Trust 140BM LCD Wireless Observation System (www.trust.com/13816) allows the user to monitor their baby or to keep an eye on their car in the garage at all times of the day and night. This security system can easily be taken to the neighbour's house, for example, so that the user can keep an eye on everything via the portable monitor. This security system transmits an interference-free signal, even through walls and ceilings. Not only the nursery, but also other rooms, such as the garage, can be viewed via the colour LCD monitor, provided they are within the maximum range of 100 metres. Since this Plug & Play system is completely wireless, the user can easily install it anywhere. This system can also be expanded using other wireless Trust video cameras and receivers.
This wireless observation system consists of two components. There is a wireless colour camera with an integrated microphone and a lens with a 1/3" CMOS sensor which can be rotated to the desired position. This camera has extra infrared LEDs for black-and-white night vision, so that a nursery, garage or other dark room can be monitored at night.
The system also consists of a wireless monitor with a 4 cm colour TFT LCD screen. This portable monitor has an integrated receiver and loudspeaker, as well as an extra video output for connecting it to a TV or video recorder using the Scart cable supplied with the system. The colour monitor can be set so that it turns on automatically when sound is registered. The monitor has buttons which can be used to turn the sound on or off and to adjust the light intensity for a longer battery life span.
The 140BM LCD Wireless Observation System operates at a wireless frequency of 2.4 GHz and has three different channels for selecting the best quality signal reception. Both the camera and the monitor are powered by the two power adapters provided or four 1.5 V AA batteries (not included). The security system comes supplied with an assembly set for attaching the camera or monitor to a wall, a Scart cable and a multi-language instruction manual. The Trust 140BM LCD Wireless Observation System will be available from the end of February.
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Are you Catherine Grenot?Claim your profile
Publications (43)101.81 Total impact
- SourceAvailable from: Marc Le Borgne
Article: Synthesis of New Steroidal Inhibitors of P-Glycoprotein-Mediated Multidrug Resistance and Biological Evaluation on K562/R7 Erythroleukemia Cells[Show abstract] [Hide abstract]
ABSTRACT: A simple route for improving the potency of progesterone as a modulator of P-gp-mediated multidrug resistance was established by esterification and/or etherification of hydroxylated 5α/β-pregnane-3,20-dione or 5β-cholan-3-one precursors. X-ray crystallography of representative 7α-, 11α- and 17α-(2'R/S)-O-tetrahydropyranyl ether diastereoisomers revealed different combinations of axial-equatorial configurations of the anomeric oxygen. Substantial stimulation of accumulation and chemosensitization was observed on K562/R7 erythroleukemia cells resistant to doxorubicin, especially using 7α,11α-O-disubstituted derivatives of 5α/β-pregnane-3,20-dione, among which the 5β-H-7α-benzoyloxy-11α-(2'R)-O-tetrahydropyranyl ether 22a revealed promising properties (accumulation index: 2.9, IC50: 0.5 µM versus 1.2 and 10.6 µM for progesterone), slightly overcoming those of verapamil and cyclosporin A. Several 7α,12α-O-disubstituted derivatives of 5β-cholan-3-one proved even more active especially the 7α-O-methoxymethyl-12α-benzoate 56 (accumulation index: 3.8, IC50: 0.2 µM). The panel of modulating effects from different O-substitutions at a same position suggests a structural influence of the substituent completing a simple protection against stimulating effects of hydroxyl groups on P-gp-mediated transport.Journal of Medicinal Chemistry 01/2015; 58(4):1832-1845. DOI:10.1021/jm501676v · 5.48 Impact Factor
Article: Progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux: Design, synthesis, characterization and biological evaluation[Show abstract] [Hide abstract]
ABSTRACT: Bivalent ligands were designed on the basis of the described close proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). The syntheses of 19 progesterone-adenine hybrids are described. Their abilities to inhibit P-glycoprotein-mediated daunorubicin efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein were evaluated versus progesterone. The hybrid with a hexamethylene linker chain showed the best inhibitory potency. The efficiency of these progesterone-adenine hybrids depends on two main factors: (i) the nature of the linker and (ii) its attachment point on the steroid skeleton.Steroids 07/2012; 77(12):1177-91. DOI:10.1016/j.steroids.2012.07.010 · 2.72 Impact Factor
Article: Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study[Show abstract] [Hide abstract]
ABSTRACT: Novel prognostic biomarkers are imperatively needed to help direct treatment decisions by typing subgroups of node-negative breast cancer patients. Large screening of different biological compartments, such as the proteome, by means of high throughput techniques may greatly help scientists to find such markers. The present retrospective multicentric study included 268 node-negative breast cancer patients. We used a proteomic approach of SELDI-TOF-MS screening to identify differentially expressed cytosolic proteins with prognostic impact. The screening cohort was composed of 198 patients. Seventy supplementary patients were included for validation. Immunohistochemistry (IHC) and immunoassay (IA) were run to confirm the prognostic role of the marker identified by SELDI-TOF-MS screening. IHC was also used to explore links between selected marker and epithelial-mesenchymal transition (EMT)-like, proliferation and macrophage markers. Ferritin light chain (FTL) was identified as an independent prognostic marker (HR = 1.30-95% CI: 1.10-1.50, p = 0.001). Validation step by means of IHC and IA confirmed the prognostic value of FTL level. CD68 IHC showed that FTL was stored in tumor-associated macrophages (TAM), which exhibit an M2-like phenotype. We report here, first, the validation of FTL as a breast tumor prognostic biomarker in node-negative patients, and second, the fact that FTL is stored in TAM.International Journal of Cancer 07/2012; 131(2):426-37. DOI:10.1002/ijc.26397 · 5.01 Impact Factor
Article: Identification of potential prognostic biomarkers for node-negative breast tumours by proteomic analysis: A multicentric 2004 national PHRC study[Show abstract] [Hide abstract]
ABSTRACT: We used a 2D-electrophoresis (2-DE) proteomic approach to identify novel biomarkers in node-negative breast cancers. This retrospective study focused on a population of patients with ductal pN0M0 tumours. A subset of patients who developed metastases and in whose tumours were found high levels of uPA and PAI-1 (metastatic relapse, MR: n=20) were compared to another subset in whom no metastatic relapse occurred and whose tumours were found to have low levels of uPA and PAI-1 (no relapse, NR: n=21). We used a 2-DE coupled with MS approach to screen cytosol fractions using two pH-gradient scales, a broad scale (3.0-11.0) and a narrower scale focussing in on a protein rich region (5.0-8.0). This study was conducted on 41 cytosol specimens analyzed in duplicate on two platforms. The differential analysis of more than 2,000 spots in 2-DE gels, obtained on the two platforms, allowed the identification of 13 proteins which were confirmed by western blotting. Two proteins, GPDA and FABP4 were down-regulated in the MR subset whereas all the others were up-regulated. An in silico analysis revealed that GMPS (GUAA), GAPDH (G3P), CFL1 (COF1) and FTL (FRIL), the most informative genes, displayed a proliferation profile (high expression in basal-like, HER2+ and luminal B molecular subtypes). Inversely, similar to FABP4, GPD1 [GPDA] displayed a high expression in luminal A subtype, a profile characteristic of tumour suppressor genes. Despite the small size of our cohort, the 2-DE analysis gave interesting results which were confirmed by the in silico analysis showing that some of the corresponding genes had a strong prognostic impact in breast cancer, mostly because of their link with proliferation: GMPS, GAPDH, FTL and GPD1. A validation phase on a larger cohort is now needed before these biomarkers could be considered for use in clinical practice.International Journal of Oncology 04/2012; 41(1):92-104. DOI:10.3892/ijo.2012.1456 · 3.03 Impact Factor
Article: Potent and Fully Noncompetitive Peptidomimetic Inhibitor of Multidrug Resistance P-Glycoprotein[Show abstract] [Hide abstract]
ABSTRACT: N(α)-Boc-l-Asp(OBn)-l-Lys(Z)-OtBu (reversin 121, 1), an inhibitor of the P-gp ABC transporter, was used to conceive compounds inhibiting the drug efflux occurring through the Hoechst 33342 and daunorubicin transport sites of P-gp, respectively H and R sites. Replacement of the aspartyl residue by trans-4-hydroxy-l-proline (4(R)Hyp) gave compounds 11 and 15 characterized by half-maximal inhibitory concentrations (IC(50)) of 0.6 and 0.2 μM, which are 2- and 7-fold lower than that of the parent molecule. The difference in IC(50) between 11 and 15 rests on the carbonyl group of the peptidyl bond, reduced in 15. Those compounds are rather specific of P-gp, having no or limited activity on MRP1 and BCRP. 15 displayed no marked cytotoxicity up to 10-fold its IC(50). Importantly, 15 equally inhibited the Hoechst 33342 and daunorubicin effluxes through a typical noncompetitive inhibition mechanism, suggesting its binding to a site different from the H and R drug-transport sites.Journal of Medicinal Chemistry 09/2010; 53(18):6720-9. DOI:10.1021/jm100839w · 5.48 Impact Factor
Article: Design, synthesis and evaluation of progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux[Show abstract] [Hide abstract]
ABSTRACT: Steroidal bivalent ligands were designed on the basis of the described closer proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). The syntheses of seven progesterone-adenine hybrids were described. Their abilities to inhibit P-glycoprotein-mediated daunorubicin efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein were evaluated versus progesterone.Bioorganic & medicinal chemistry letters 05/2010; 20(10):3165-8. DOI:10.1016/j.bmcl.2010.03.085 · 2.33 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Testosterone (T) circulates in the blood tightly bound to sex hormone-binding globulin (SHBG) and weakly to albumin. Measuring protein unbound T (free) or non-SHBG-bound T rather than total T has been recommended for the evaluation of androgen disorders in humans. Ammonium sulfate precipitation has been widely used to separate [SHBG-T] complex from free and albumin-bound T. To achieve more specificity in this separation, we used monoclonal anti-SHBG antibody and developed a suitable and convenient immunoassay for measuring non-SHBG-bound T. Magnetic beads were covalently coupled to a monoclonal anti-SHBG antibody to capture [SHBG-T] complex from plasma samples. Magnetic separation was then performed to allow measurement of non-SHBG-bound T in the supernatant by direct radioimmunoassay. When 300 microL of plasma samples were incubated at room temperature with 10 microL of anti-SHBG beads, residual SHBG concentration was undetectable in the supernatant. The specificity of proteins retained on anti-SHBG beads was further demonstrated by peptide mass fingerprint on a MALDI-TOF analyzer. The non-specific adsorption of T on beads was low (5%), and dissociation of T from SHBG-T complex was less than 5% after 180 min of incubation. The plasma concentrations of non-SHBG-bound T using anti-SHBG beads were highly correlated to those obtained using ammonium sulfate precipitation. We conclude that SHBG immunocapture is a highly specific and useful tool for an experimental direct measurement of plasma non-SHBG-bound T. This methodology is also convenient and appropriate for routine and automated assay.Analytica chimica acta 01/2010; 658(1):87-90. DOI:10.1016/j.aca.2009.10.057 · 4.52 Impact Factor
Article: Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome[Show abstract] [Hide abstract]
ABSTRACT: Sex hormone-binding globulin (SHBG) is the main transport binding protein for sex steroid hormones in plasma and regulates their accessibility to target cells. Plasma SHBG is secreted by the liver under the control of hormones and nutritional factors. In the human hepatoma cell line (HepG2), thyroid and estrogenic hormones, and a variety of drugs including the antioestrogen tamoxifen, the phytoestrogen, genistein and mitotane (Op'DDD) increase SHBG production and SHBG gene promoter activity. In contrast, monosaccharides (glucose or fructose) effectively decrease SHBG expression by inducing lipogenesis, which reduces hepatic HNF-4alpha levels, a transcription factor that play a critical role in controlling the SHBG promoter. Interestingly, diminishing hepatic lipogenesis and free fatty acid liver biosynthesis also appear to be associated with the positive effects of thyroid hormones and PPARgamma antagonists on SHBG expression. This mechanism provides a biological explanation for why SHBG is a sensitive biomarker of insulin resistance and the metabolic syndrome, and why low plasma SHBG levels are a risk factor for developing hyperglycemia and type 2 diabetes, especially in women. These important advances in our knowledge of the regulation of SHBG expression in the liver open new approaches for identifying and preventing metabolic disorder-associated diseases early in life.Molecular and Cellular Endocrinology 09/2009; 316(1):53-9. DOI:10.1016/j.mce.2009.09.020 · 4.24 Impact Factor
Article: P2-070 - CBF-A lie le motif (TAAAA)6 au niveau du promoteur du gène de la SHBG humaineet régule négativement son activité de transcriptionAnnales d Endocrinologie 10/2006; 67(5):496-496. DOI:10.1016/S0003-4266(06)72901-8 · 0.66 Impact Factor
Article: P170 - Mécanismes de régulation hormonale du gène de la SHBG in vitro. Purification d'une protéine de 46 KDa liant le motif (TAAAA)n du promoteur SHBGAnnales d Endocrinologie 09/2004; 65(4):372-373. DOI:10.1016/S0003-4266(04)95881-7 · 0.66 Impact Factor
Article: Intravenous injection of human sex steroid hormone-binding globulin in mouse decreases blood clearance rate and testicular accumulation of orally administered [2-I-125]iodobisphenol A[Show abstract] [Hide abstract]
ABSTRACT: Bisphenol A, an environmental compound with estrogenic activity, has been shown to bind human sex steroid hormone-binding globulin (hSHBG), the main plasma transport protein which regulates the metabolism of androgens and estrogens and limits their access to target organs. The present study was conducted to determine whether physiologically relevant concentrations of hSHBG can influence the blood clearance rate of bisphenol A and its accumulation in the testes. A radioactive [2-125I]iodobisphenol tracer was synthesized with an association constant (Ka) for binding to hSHBG of 0.14 +/- 0.01 x 10(6) M(-1) at 37 degrees C, a value much lower than for [2-125I]iodoestradiol, which was also synthesized. We used i.v. injection of immunopurified hSHBG in adult male mice to maintain hSHBG levels within the physiologically possible range for humans (27-267 nM) before gavage administration of [2-125I]iodobisphenol or [2-125I]iodoestradiol, for measuring the blood clearance rate of radioactive signal in blood samples taken during the following 120 min. Testicular accumulation of radioactivity was measured 24 h and 48 h after gavage of [2-125]iodobisphenol A. In mice receiving immunopurified hSHBG or vehicle, the time-dependent blood clearance of radioactivity exhibited a bi-exponential decrease which indicated alpha-diffusion and beta-elimination phases for both radioactive ligands. The presence of circulating hSHBG significantly and dose-dependently lowered the clearance rate of radioactivity. However, much higher circulating levels of hSHBG were required to retard the blood clearance of [2-125I]iodobisphenol A as compared to those required for [2-125I]iodoestradiol, in keeping with the important difference in their respective Ka value for binding to SHBG. In addition, mice treated with hSHBG exhibited significantly (P = 0.036) reduced testicular accumulation of radioactivity 24 h and 48 h after ingestion of [2-125I]iodobisphenol A. Provided that the binding properties of bisphenol A for hSHBG are not substantially different from those measured for [2-125I]iodobisphenol A, these findings suggest that, although hSHBG binds 2-mono-iodobisphenol A with a relatively low binding affinity, high enough concentrations of circulating hSHBG (range concentrations between 85 and 267 nM) are potentially able to exert a protective effect against exposure to bisphenol A.Steroids 07/2002; 67(7):637-45. DOI:10.1016/S0039-128X(02)00014-4 · 2.72 Impact Factor
Article: Specific photoaffinity-labeling of Tyr-50 on heavy chain and of Tyr-32 on the light chain in the steroid combining site of a mouse monoclonal anti-estradiol antibody using C3-, C6-, and C7-linked 5-azido-2-nitrobenzoylamidoestradiol photoreagents[Show abstract] [Hide abstract]
ABSTRACT: A mouse monoclonal anti-7-(O-carboxymethyl)oximinoestradiol antibody 9D3, raised against the same immunogen as that employed for generating the reported anti-estradiol antibody 15H11 [Rousselot, P., et al. (1997) Biochemistry 36, 7860-7868], was found to exhibit an opposite specificity profile with a much stronger recognition of the D-ring than of the A-ring extremity of the steroid, but a similar lack of specificity for both 6- and 7-positions of the B-ring. This antibody was photoaffinity-labeled with five (5-azido-2-nitrobenzoyl)amido (ANBA) derivatives of [17alpha-(3)H]estradiol, synthesized from 3-aminoethyloxy, 3-(aminoethylamido)carboxymethyloxy, 6alpha- and 6beta-amino, and 7-[O-(aminoethylamido)carboxymethyl]oximino precursors. After tryptic digestion, the radioactive peptides on L and H chains were immunopurified with the immobilized antibody 9D3, separated by reversed-phase liquid chromatography, sequenced, and characterized by mass spectrometry, including post-source decay-matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The long 3-(ANBA-ethylamido)carboxymethyl ether photoreagent was found to label TyrL-32 (on CDR L1), whereas no labeling was observed with the shorter 3-derivative, a result in agreement with a binding pocket large enough to explain the high cross-reactivity with estradiol 3-conjugates. The two 6alpha- and 6beta-ANBA-estradiol isomers, as well as the 7-[O-(ANBA-ethylamido)carboxymethyl]oximinoestradiol photoreagent derived from the steroid hapten, labeled the same TyrL-32 residue. The 6beta-ANBA epimer also labeled TyrH-50 (at the basis of CDR H2). These experiments indicate that TyrL-32 is freely accessible from the three C3, C6, and C7 positions, all presumed to be exposed to solvent, while TyrH-50 is probably located on the beta-face of estradiol. These results, obtained in solution, provide experimental data useful for molecular modeling of the steroid-antibody complex.Biochemistry 01/2002; 40(49):14907-20. · 3.19 Impact Factor
Article: Photoaffinity labeling of human sex hormone-binding globulin using 17alpha-alkylamine derivatives of 3beta-androstanediol substituted with azidonitrophenylamido, azidonitrophenylamino, or trifluoroazidonitrophenylamino chromophores. Localization of Trp-84 in the vicinity of the steroid-binding site.[Show abstract] [Hide abstract]
ABSTRACT: Purified human SHBG was photoaffinity labeled with 17alpha-aminomethyl (M), 17alpha-aminoethyl (E), and 17alpha-aminopropyl (P) derivatives of [3alpha-(3)H]-5alpha-androstane-3beta,17beta-diol coupled to 5-azido-2-nitrobenzoylamido (ANB), 4-azido-2-nitrophenylamino (ANP), and 5-azido-2-nitro-3,4,6-trifluorophenylamino (ANTFP) chromophores. Successful labeling was achieved in all cases except for the two photoreagents with the shortest side chains, namely, ANP-M and ANTFP-M derivatives. Edman sequencing and mass spectrometry of immunopurified photolabeled tryptic fragments revealed that radioactivity was present either on the sequence of residues 73-94, uniquely at the level of Trp-84 (stable covalent labeling), or on one of the two overlapping sequences of residues 126-134 and 126-135, at the level of Pro-130 (labile labeling) and Lys-134 (either stable or partially labile labeling), respectively. The same Trp-84 was photolabeled with the three ANB derivatives of increasing lengths, and by the ANP-P photoreagent. This residue was the exclusive target for the shortest [(3)H]ANB-M photoreagent but was a minor site for the longest [(3)H]ANB-P photoreagent, essentially recovered at the level of Pro-130. The [(3)H]ANB-E photoreagent of intermediate size also labeled exclusively Trp-84, except in some experiments in which photolabeling was recovered predominantly at the level of Pro-130. The [(3)H]ANP-P photoreagent with an overall length similar to that of the ANB-P photoreagent labeled simultaneously Trp-84 (minor site) and Lys-134. The other [(3)H]ANP-E, [(3)H]ANTFP-E, and [(3)H]ANTFP-P derivatives labeled in all cases Lys-134. These findings indicate that the conserved Trp-84 and the two Pro-130 and Lys-134 residues are all located in the vicinity of the D ring of steroid ligands and remain freely accessible from the C17alpha position, thus providing biochemical data delineating the corresponding region of the steroid-binding site.Biochemistry 01/2002; 40(50):15424-35. · 3.19 Impact Factor
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University of LyonLyons, Rhône-Alpes, France
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French Institute of Health and Medical ResearchLutetia Parisorum, Île-de-France, France


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Brett L. Seamons, Ph.D., of Seattle has joined Milwaukee-based Lichter & Ihle as a partner. Lichter & Ihle provides consulting services to mid-size and global companies to assist with leadership succession, executive coaching and development, talent assessment, organizational effectiveness, team building and acquisition integration.
Seamons has nearly 20 years of experience with individual, team and organizational development and has conducted a wide range of coaching assignments, organizational studies and leadership assessments.
Prior to joining Lichter & Ihle, he was with RHR International for 16 years. He spent six years in the company's London office, moved to Chicago for five years and then worked in Seattle for six years. Seamons' experience also includes time with Ford Motor Company and a faculty position at Wayne State University in Detroit.
Seamons received his B.S. and M.S. degrees in Psychology from Brigham Young University, earned his Psychology Ph.D. at Saybrook Univeristy and is a member of the American Psychological Society.
Lichter & Ihle is located at The City Center, 735 N. Water St., Suite 712, Milwaukee.
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By Ryan Clark | March 13, 2011 | Comments
-- As noted last night here on WrestlingINC.com, Ric Flair was unable to make a scheduled appearance for WWE Hall of Famer Harley Race's World League Wrestling promotion yesterday because his morning flight to Missouri was canceled and he failed to board a later one. World Wrestling Entertainment did in fact send RAW Superstar Ted DiBiase on short notice to replace Flair at Race's event.
-- The TNA Genesis DVD is on sale this Tuesday at major retailers and ShopTNA.com.
-- Generation Me member Max celebrates his 26th birthday today.
WWE NXT Live Event Results From Lakeland (7/31): Finn Balor Vs. Solomon Crowe, Divas Team Up, More
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WWE Officials Reportedly Want Tough Enough Competitor To Be Eliminated Next Tuesday
John Cena Undergoes Surgery, Why Match Was Nixed On WWE SmackDown


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Conflict Minerals Filings Below Estimates
More than 1,300 companies made their first conflict minerals filings in accordance with a new Securities and Exchange Commission rule, though the number was far less than expected, according to a report by Ernst & Young.
Early estimates indicated around 6,000 companies would be affected by the rule and that 4,500 would be required to file a conflict minerals report with the SEC. Ultimately only 1,315 companies filed a Form SD, and of those, only 77 percent filed an associated CMR.
Many companies indicated earlier this year that they were unlikely to meet the May 31 deadline.
Of the companies that did file, only four obtained an independent private sector audit of their CMR that included the due diligence framework and activities undertaken.
Most filers were not able to determine the origin of tungsten, tantalum, tin and gold in their products and filed a CMR stating the need for further due diligence. In addition, more than 40 percent of filers said that at least some portion of their sourcing originates in the covered countries, but indicated that additional due diligence was needed for some portion of their product components and suppliers.
About half of the filers were able to identify some portion of smelters as conflict-free, but only 27 percent provided a list of smelters and refiners.
Many of the reporting companies have complex supply chains and noted difficulties in tracing the 3TG in their products because of insufficient responses to their inquiries from suppliers. Uncooperative suppliers, as a whole, were reported as the reason why many of the CMRs did not include the level of detail that was expected.
The top 10 sectors with SD filings were:
• 22 percent, technology
• 14 percent, diversified industrial projects
• 13 percent, consumer projects
• 11 percent, retail and wholesale
• 9 percent, pharmaceuticals
• 6 percent, oil and gas
• 5 percent, automotive
• 4 percent, aerospace and defense
• 4 percent, chemicals
• 3 percent, mining and metals
• 9 percent, all other sectors
Photo Credit: Poura Gold Mine, Gilles Paire/Shutterstock.com
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Jamaica 1-2 USA: All three points after heartbreak seemed imminent
Jun 7, 2013, 11:36 PM EDT
Brad Evans' first career international goal turned out to be a big one.
Just when the United States thought Jermaine Beckford had burgled a draw with an 89th minute goal off a set piece, Evans found space and fired a prayer which found the back of the net.
A slow match for much of the second half suddenly jolted to life when Beckford connected on a header off a long free kick and stunned the USA, who had been caught napping late.
It seemed like more of the same for Jurgen Klinsmann's men. Coming into the match, the United States had scored first in 5 of 6 road qualifiers this World Cup cycle, but had only 4 points to show for it.
The win gives the U.S. sole possession of first place in the Hexagonal table, jumping past Mexico who defeated the Reggae Boyz just three days ago.
(UPDATE: After Mexico's draw with Panama and Costa Rica's win over Honduras, there's a three-way tie for first place in the group, with the United States sitting in second place on goal differential)
The match started in the U.S.'s favor, with Michael Bradley hitting the post early and Fabian Johnson ravaging Jamaica's right flank. Finally the US opened the scoring when Graham Zusi's cross connected with Jozy Altidore's head.
On the other end, the United States back four bent a few times but refused to break for much of the match, and looked set picked up their third clean sheet of Hex play until the late set piece goal.
Early in the second half the U.S. lost Jermain Jones to a concussion (it appeared he may have been knocked out), and the passing subsequently because a bit inaccurate, but the defense held against the growing pressure from Jamaica.
The pace of the game really slowed down after the goal, and neither team seriously threatened on net for a while aside from a shot off the post from Jamaica just before the half. Dempsey also had a bit of a chance on a chip in from Bradley, but the header from the captain went just over.
In the final 15 minutes, both teams found it difficult to hold possession for any length of time as the heat and humidity seemed to affect each side. The 76th minute saw Jamaican substitute Theo Robinson shoot wide of Tim Howard's goal before U.S. substitute Edgar Castillo tried a long-range chip on the counter and also put it just wide of the far post.
The defense proved leaky again, and the heat proved an enemy of the visitors, but late drama grabbed a much needed victory when it counts.
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The Yankees would love to have Adam Dunn and Joakim Soria
Jul 16, 2010, 6:14 PM EDT
At the risk of Derrek Lee coming out and saying that no one on the Yankees knows Ken Rosenthal, the FOX scoopsmith (eh? OK, I won't say that again) reports that the Yankees would love to have Adam Dunn and Joakim Soria.
Hard to say what level of interest this really is, but boy howdy would it be scary for everyone in the American League if New York got either of these guys. Dunn and that right field porch in Yankee Stadium would be a match made in heaven. A one-two punch of Soria and Rivera would be unfair in the extreme. It'd be fun to see even if it would be practically obscene that one of the league's best closers was working as a setup man in the Bronx.
This just smells like chitchat, though, not anything New York can really be considering. I can picture a conversation in which Rosenthal's Yankee source says "well, we tried for Lee, but beyond that we're not going to do much." When pushed he says "well, hell, we'd love to have Adam Dunn or Joakim Soria . . ."
And yes, I make up conversations like that all the time. It's fun!
- willmose - Jul 16, 2010 at 7:09 PM
Didn't Rosenthal also say that Mark McGwire would be a huge distraction for the Cardinals this season? Oh, wait he took that back about a month ago. I'm guessing he will take back what he saying about Derrek Lee, Adam Dunn and Joakin Soria on August 1st when none of them change teams. Never mind, I forgot Rosenthal is a just a gossip columnist not a reporter.
- bigtrav425 - Jul 16, 2010 at 7:12 PM
They dont have enough to give up for those guys..unless they just paid cash for them..which is what the yanks do best!
- 2cents - Jul 16, 2010 at 7:24 PM
About a week ago I had the thought Dunn would end up a Yankee.Don't remember why. Maybe the defence thing might be an issue but who knows. I think he'd be a good fit. Boras isn't his agent is he?
- Paper Lions - Jul 16, 2010 at 10:35 PM
There are 29 teams that would love to have Soria and at least a dozen that would love to have Dunn. When is Rosenthal's report that the Yankees would love to Pujols, Utely, Zimmerman, Heyward, Santana, Halladay, and Lincecum coming out?
- JBerardi - Jul 17, 2010 at 12:15 AM
I agree, except that you might be selling Dunn short.
- DavidBurden - Jul 17, 2010 at 2:29 AM
I'm really hoping this was a reference to The Poopsmith.
- Barney - Jul 22, 2010 at 7:27 AM
The Yankees are loaded in the minors they have 3 top catching prospects Montero, Romine and Sanchez they also have many attractive pitching prospects Phelps, Sanchez, Nova, Noesi, Melancon, Warren, Stoneburner, Ramirez and Hall. If they needed they have a few position players the could be used Miranda, Nunez, Adams, Laird, Vazquez, and Joesph. If you offered KC a package starting with Montero then one of the pitchers and a position player I think you would attract there attention, I wouldn't trade Montero for any other relief pitcher but Soria he is under team control for a couple of years and would be a candiate to take over for Mo. Then for Dunn you could start the package with Miranda or Vazquez, a good pitcher and a "B" prospect. I think for a pitcher like Soria it would be worth it.
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SFV650 Gladius '09-'15
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This bag only works with ION tank ringsThe new ION series from SW-MOTECH Bags-Connection is a budget minded tankbag that is not built on a budget. Loaded with the same features as the higher priced bags, the new ION 3 fits perfectly on tanks that are slightly curved and is perfect for longer trips where you need more storage space than the ION 1 or ION 2. Learn More$171.95
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The Micro is a small 2.5-5 liter tankbag. Fits most bikes and is an excellent around town bag. Compatible with the SW-MOTECH Bags-Connection Electric EVO QUICK-LOCK Tankrings, see the app chart below to determine which electric tankring is appropriate for your bike.Learn More$199.95
SW-MOTECH DAKAR Waterproof Soft Saddlebags for SW-MOTECH, Givi & Other Sidecarriers
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Washington got 10 hits off Minnesota left-hander Glen Perkins, but the only one that went for extra bases was Young's solo homer in the eighth. And the Nationals left 10 men on base a day after stranding 12 runners.
And as much of the loss as Hill wanted to put on himself, Young saw a bigger picture.
When asked what's wrong with the Nationals, he simply answered, "A lot."
"We can't start nitpicking, pointing fingers and things like that," Young added. "We win as a team. We lose as a team. When it turns, it's going to turn for the better."


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Tel: (281)583-1984
Darul Arqam schools are committed to instilling in our children, Islamic values, habits, attitudes,high moral and ethical standards, tolerance, and patience that are characteristics of a good Muslim.
With the help of Allah(swt) we shall prepare our children to become Muslim role models, exemplary citizens in their communities, and to excel in their professional careers.
Darul Arqam schools will prepare our children to read and understand the message of the Quran, and the Sunnah of Prophet Muhammad (saaws) and teach the students to apply it in every facet of their personal and professional lives.
Darul Arqam follows a curriculum that is aligned with the State of Texas, Essential Knowledge and Skills (TEKS) objectives for all secular subjects.
All textbooks with the exception of Arabic and Islamic studies are State of Texas Education Agency-approved.
These textbooks have the latest TEKS/TAKS directives and are identical to those currently being used in area public school districts.
School Overview
|School Membership(s)School Assoc.
|Other school association(s)
|Religious Affiliation
|Grades Offered
|Grades Prekindergarten - 12
Student Body
|Total Students
|277 students
|Student Body Type
|% Students of Color
State avg.: 37%
|Students by Grade
Academics and Faculty
|Total Classroom Teachers
|28 teachers
|Student : Teacher Ratio
National avg.: 13:1
Nearby Schools:
All Schools | High Schools | Elementary Schools | Preschools | Public Schools
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- School Location Miles Grades Students
Houston11249 Crown Park Dr
Houston, TX 77067
(281)876-5360(Christian)0.9 mi | Gr. K-2 | 62 students
Houston13331 Kuykendahl Rd # 101
Houston, TX 77090
(281)872-8814Daycare / Preschool1.9 mi | Gr. K | 36 students
Houston14901 Welcome Lane
Houston, TX 77014
(281)444-9433Montessori School3 mi | Gr. NS-1 | 59 students
Houston14314 Walters Rd
Houston, TX 77014
(281)580-1671(Baptist)3 mi | Gr. PK-11 | 61 students
Houston1122 West Rd
Houston, TX 77038
(281)999-5107(Assembly of God)3 mi | Gr. PK-6 | 183 students
School Reviews
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Recent Articles
Updated July 12, 2015
Many parents tend to dismiss the idea of sending their children to private school without exploring it in depth. We explore this and several more related subjects.
When it comes to choosing a private school, there are so many choices to consider that the project can be a huge challenge to most of us. We offer some help and advice to help you get started.
Sending your child to a foreign language school makes good sense when you have been posted to this country from abroad and in other circumstances as well.


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Poplar Bluff Transportation Dept
1.Missouri State of-- Transportation Dept of-- Unemployment Claim Filing/Inquiry-- 205th Mp Bn - CLOSED
1605 Cravens RdPoplar Bluff, MO 63901
2.Transportation Department
3568 Highway 67 NPoplar Bluff, MO 63901
3.Department of Transportation
13148 Highway 53Qulin, MO 63961
4.Doniphan R1 School Transportation Department
309 Pine StDoniphan, MO 63935
5.US Department of Agriculture
18450 Ridgeview LnDexter, MO 63841
6.B4 Logistics Inc.
8.RoadRunner Auto Transport
Serving the Poplar Bluff Area.
9.American Freight Inc Trucking & Freight Brokers
Serving the Poplar Bluff Area.
10.Iron Highway Enterprises
11.Ride-A-Way Vehicle Transport
12.Pilot Cars B-4 Transportation
13.Global Quote Logistics LLC
Serving the Poplar Bluff Area.
14.State of Missouri
218 N Broadway StPoplar Bluff, MO 63901
15.Division-Workforce Development
1903 Northwood Dr Ste 2Poplar Bluff, MO 63901
16.Ozark Foothill Regional Planning Commission
3019 Fair StPoplar Bluff, MO 63901
17.Missouri State Mental Health Department
2351 Kanell BlvdPoplar Bluff, MO 63901
18.Veterans Commission
218 N Broadway St # BPoplar Bluff, MO 63901
19.Health & Senior Svc Dept
2875 James BlvdPoplar Bluff, MO 63901
20.State Of Missouri
107 Magazine LnPoplar Bluff, MO 63901
21.Sierra Osage Treatment Center
9200 Sierra Osage CirPoplar Bluff, MO 63901
22.Highway Dept Construction Ofc
2910 Barron RdPoplar Bluff, MO 63901
23.Aging Division
2875 James BlvdPoplar Bluff, MO 63901
24.Representative Matt Richardson
123 S 2nd StPoplar Bluff, MO 63901
25.Natural Resources Dept
2155 N Westwood BlvdPoplar Bluff, MO 63901
26.Gregory Logistics Inc
2844 Fair StPoplar Bluff, MO 63901
27.State of Missouri National Guard
1607 Cravens RdPoplar Bluff, MO 63901
28.Corrections Dept-Probation
1441 Black River Ind Park RdPoplar Bluff, MO 63901
29.Children & Youth Svc
9400 Sears LnPoplar Bluff, MO 63901
30.Transport One
1618 S Broadway StPoplar Bluff, MO 63901
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CBR TV: Palahniuk & Mack Talk "Fight Club 2," Sensitive Subjects & Cover Controversies
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Marking Time
Simon and Schuster, Jul 1, 1995 - Fiction - 416 pages
The wonderful sequel to The Light Years returns readers to Britain in September, 1939, as war breaks out. Sheltered Louise, now 16, goes from cooking school to London parties. For 14-year-old Polly, the terrors of war cannot forestall the pangs of adolescence. And though Clary's father has been reported missing since Dunkirk, she holds to the belief that he's alive.
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Review: Marking Time (Cazalet Chronicles #2)User Review - Sarah Evans - Goodreads
enjoyable - imagine Downton Abbey but with better writing and later in years. Read full review
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Review: Marking Time (Cazalet Chronicles #2)User Review - Elinor - Goodreads
Just finished the second book of the Cazalet Chronicles, and can't wait to start on the third. I'm now so involved in the lives of this English family that feel as if I know them. I'm already dreading turning the last page of the fifth and final book in the series. Highly entertaining family saga. Read full review
Selected pages
January 1940
MayJune 1940
July 1940
AutumnWinter 1940
AutumnWinter 1940
WinterSpring 1941
JulyOctober 1941
AutumnWinter 1941
Common terms and phrases
afraid anyway Archie asked Aunt Rach Aunt Syb Aunt Villy awful awfully baby bath better Brig called Cazalet Christopher Clary course Cripps dark darling dinner door dress Duchy Elizabeth Jane Howard Ellen everything eyes face father feel felt Frensham girl gone Hadleigh hair hand happened Hermione Home Place Jessica Juliet kind kissed knew Lady Rydal Lansdowne Road London looked Louise thought lunch Lydia married mean Michael mind Miss Milliment morning mother Mummy never Neville nice night Nora nurse Pipette play Polly Rachel round Rupert seemed silence Simon simply smiled someone sorry sort sounded stay Stella stop suppose Sybil talk Teddy tell there's things told Tonbridge took trying turned Uncle Hugh walk Watlington week weekend wonderful worry write


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McCarthy: Barnsley a Fabulous Club
Saturday, 19th Jan 2013 06:04
Depending on the outcome of this morning's stadium and pitch inspection, Blues boss Mick McCarthy will face his hometown side Barnsley today, a "fabulous" club he says he loves, having started his playing career at Oakwell.
McCarthy said: "It gave me my start in what seems to be a one hundred-year career now. I was there for seven and a half years, from the age of 16 to 23.
"I made my debut there, I played 272 league games over a long period of time from getting in the team at 18.
"I love the place, it gave me my chance. It's a fabulous club, lovely people. They all are from Barnsley, as you know, nice, endearing to everybody!
"They've just been having it tough. They had a great result against Leeds. And let me tell you, when I was [growing up] there, Barnsley were in the Fourth Division and Leeds were Jack Charlton, Norman Hunter, Gary Sprake, Paul Reaney, Don Revie, all them and revered by the rest of us Yorkshire folk.
"So, to slap them at home is a great result. If the game is on, they'll be coming down here feeling confident, they played well last week."
McCarthy played under one of his Leeds boyhood heroes at Barnsley: "Allan Clarke was manager when I was there as a young player and it was wonderful when he turned up because Leeds were my team, that great team.
"I remember watching him with my dad on the Kop when he was playing for Leicester. He left [for Leeds] for £175,000, that was his fee, I think.
"It was wonderful when he came to Barnsley, it just made us more professional. It was suddenly club suits and ties, kit was getting washed. He upped the standard of it all and we got promoted. He was fabulous for us, Clarkey."
He says he learnt some important lessons under the former striker: "He gave me that bit of advice – you head it, win it, tackle and give it to someone who can play! Which really, really annoyed me. It upset me for about four years until I was 23 and realised it was the best information I'd been given.
"He topped me in training once," he added. "I think I maybe kicked him once or twice as well. He was great for the club. He really upped the standard of it and then Norman Hunter came and took it on even more."
Current manager David Flitcroft succeeded his former boss Keith Hill earlier this week and McCarthy wishes him well, aside from in fixtures against the Blues: "There were all sorts of names mentioned, I saw David say he was ready to do it.
"Listen, on the back of that result, beating Leeds at home [he's justified in saying that], and they had some great results prior to that.
"We watched the game and they played very well. They were all over them and they should have beaten them by more than they two they did.
"I'm glad for David, he knows the players, he knows what he wants out of them and sometimes bringing somebody else in doesn't work, so good luck to him, except for tomorrow."
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Cafod's total income rises by 9 per cent
28 Jul 2015
Catholic Aid for Overseas Development's total income rose by £4.8m to £56m in the year ending 31 March...
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The Attorney General has rejected calls from Conservative MPs to investigate the RSPCA's prosecutions.
And the Charity Commission and the RSPCA have both denied leaking a letter to the Telegraph newspaper about the charity's prosecutions.
The denials came just hours before a Westminster Hall debate on the RSPCA today which saw the charity accused of using prosecutions to drive a political ideology and in turn defended as an upholder of the law.
Conservative MP Simon Hart, who led the debate, accused the RSPCA of being a prosecutor which did "politics in a big way".
He also said there was a "gulf between the very good activity of inspectors on the ground whose principal concern is animal welfare and the leadership whose principal concern seems to be animal rights".
In the debate, Hart referred to a leaked letter reported in the Telegraph today from Charity Commission chief executive Sam Younger to Gavin Grant, chief executive of the RSPCA. Hart said the Charity Commission "rebuked" the RSPCA in the letter.
According to The Telegraph, Younger's letter said the RSPCA should review its prosecution policies "given the amount of adverse publicity and the allegations of political bias that the charity had attracted as a result of the case".
The Charity Commission refused to comment on the letter and its contents and told civilsociety.co.uk this morning that it did not send it to the Telegraph. An RSPCA spokeswoman said: "You can be pretty safely assured that the RSPCA did not send the Telegraph the letter."
The parliamentary debate today centred on the RSPCA's prosecutions. It follows a political row between a group of cross-party MPs who have called on the Charity Commission to investigate the RSPCA's prosecution of the Heythrop Hunt, the first successful prosecution of a hunt brought in the UK. The Charity Commission has said there is no regulatory concern and it will not investigate the charity.
During the debate a number of Conservative MPs said the RSPCA had turned from a body concerned with animal welfare to a body following a political ideology of animal rights. MPs also warned that there was a public perception that its prosecution of hunts were political.
Tory MP Glyn Davies warned that the RSPCA would lose support for becoming too concerned with animal rights and not animal welfare.
However a number of Labour MPs, and Green MP Caroline Lucas, defended the RSPCA.
Labour MP Emily Thornberry accused Conservative MPs of being disappointed that the government would not change laws on hunting, so they'd turned on the RSPCA instead.
Lucas also called the debate a "smokescreen" asserting that the RSPCA was within its rights to uphold the law.
Another Labour MP also said it was a smokescreen for the RSPCA having the temerity to prosecute a hunt in David Cameron's constituency.
Earlier this month, Hart said there was a "political edge" to RSPCA's prosecution of the hunt, saying it was odd that they targeted Cameron's constituency.
Ending the debate, the Attorney General Dominic Grieve QC rejected calls to investigate the RSPCA's prosecutions, saying to do so would be "too difficult".
Richard Lionheart
30 Nov 2014
The RSPCA killed 43,000 animals in 2012, including 3400 perfectly fit, healthy dogs, which it claimed it couldn't afford to house and keep. The hypocrisy of this is illustrated by the fact it also spent £8m pursuing fox hunters, and has £110m in the bank. It wastes millions of pounds on imitation police uniforms, designed to fool the public into thinking it has legal powers (which it doesn't, not one single one). It wastes money on posh office blocks stuffed with grossly overpaid and useless pen pushers, some on grossly inflated salaries.
Poppy Field
30 Jan 2013
Can someone explain what the difference is between "animal rights" and "animal welfare"? I would have thought they were one and the same thing. Maybe just another case of politicians using emotive language to try and hoodwink the public?
John Smithy
30 Jul 2013
Response to [Poppy Field]
"ANIMAL RIGHTS" is a philosophical view that puts animals on the same moral plane as humans and rejects the use of animals for any reason whatsoever. Amongst the long-term goals of the Animal Rights movement are the total ban of all forms of commercial animal agriculture, medical or veterinary research, zoos (regardless of how well managed), the end of hunting, shooting, horse riding and racing, rodeos, show jumping, zoos, circuses, guide dogs for the blind, the keeping of pets, the production of silk, wool and honey and the abolition of fishing.
"ANIMAL WELFARE" concerns itself with preventing mistreatment and cruelty to animals. We don't necessarily oppose the various forms of animal use (such as animal agriculture, medical research, sport and trophy hunting, animals in entertainment, etc.) as long as it isn't cruel. Animal Welfare supporters might feel that eating meat is okay, as long as the animals were well treated during their lifetimes and that their deaths were as quick and painless as possible.
Animal Welfarists 'use animals' but try to do so in the most humane method possible. They try to modify animal-using practices to get the best possible conditions for, and treatment of, animals.
The ANIMAL RIGHTISTS don't think people should be 'using animals' at all, no matter if it's cruel or not.
Animal WELFARE is seen by some as the opposite of animal RIGHTS in that WELFARISTS seek to moderate animal using practices that Animal RIGHTS groups want to completely abolish.
30 Jan 2013
Simon Hart has gone into paliament for his own reasons so it is no surprise that he is wasting parliamentary time on his own political agenda and his fox hunting friends who stood up for him, surely have better time to spend on their constituents rather than defending their own bloodthirsty sport. I hope the electorate know their names and boot them out at the next election.
Karen Evans
30 Jan 2013
Simon Hart is my local MP, & is the ex CEO of the Countryside Alliance whose main purpose is to make hunting legal again. The RSPCA work hard to bring criminals to justice, including hunts acting illegaly. I just hope Mr Hart never knocks on my door wanting me to vote for him
30 Jan 2013
Clearly it is Adam Hart who is politically motivated. Personally I've never understood how the Countryside Alliance Foundation has been allowed to continue as a charity, given its misrepresentation of wildlife conservation, which it seems to equate with conserving game birds for shooting. They are just a political lobby group, as this debate highlights, and as a charity have access to schoolchildren to pass on their philosophy. Where is the public benefit in that?
29 Jan 2013
No one is complaining about the RSPCA bringing a prosecution. The complaint is the excessive amount of public funds they spent on the prosecution - I understand it was about ten time the amount spent on the defense. AND the RSPCA did not use their own in-house lawyers (why bother to have such posts if they are not used?!), preferring instead to use a hotshot dfirm of City lawyers who were not even specialists in the area of animal welfare!!!!
Peter Moss
29 Jan 2013
Whilst it is probably hard for you to accept Mr Hart, the law of the land does apply to everyone. Meanwhile, I have little doubt that your constituents know who is doing "politics" in a big way.
Richard Lionheart
5 Aug 2013
Response to [Peter Moss]
Just because its law doesnt make it right. Slavery was legal once, you going to defend that ?
Andrew Pring
29 Jan 2013
It is strange that MPs who are responsible for passing legislation then criticise those who work to enforce it.
I see no place for those who seek to undermine the authority of the law in this way in our parliament.
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28 Jul 2015
Catholic Aid for Overseas Development's total income rose by £4.8m to £56m in the year ending 31 March...
27 Jul 2015
More than 400 charity sector jobs are at risk after Broadcasting Support Services, a charity helpline...
23 Jul 2015
The Cabinet Office has been criticised by the National Audit Office for weak design and poor oversight...
28 Jul 2015
The Etherington Review of fundraising self-regulation has today published a list of questions for charities...
28 Jul 2015
The National Garden Scheme has raised a total of £15m for Macmillan Cancer Support over 30 years, becoming...
27 Jul 2015
Cancer Research UK has announced that Ed Aspel will replace Richard Taylor as executive director of fundraising...
7 Jul 2015
JustGiving launched a free guide yesterday to help charities use data to shape fundraising strategies....
3 Jul 2015
The Institute of Fundraising has unveiled a new mobile-compatible website which it says better "reflects...
2 Jul 2015
It is "not an option" for charities to have websites which don't work on mobile, because donors are increasingly...
Attending our one day courses is a highly effective way of ensuring new and existing trustees fully understand their role, responsibilities and liabilities.
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Every once in a while, a crisis comes along that tells you everything you need to know about the character and courage of our elected leaders. When circumstances collide to create a situation where only tough trade-offs and compromises offer the chance for a real solution to a problem, that's when you can see if the people we have entrusted with elected office are up to the task.
Standing beside West Point Lake in the spring of 2004, Gov. Perdue signed House Bill 237, establishing the State Water Council and requiring it to present to the Georgia General Assembly a statewide water management plan for its approval in the 2008 Session.
Hold on children. Help is on the way!
As we approach the midpoint of this session of the Georgia General Assembly, the Senate is still hard at work addressing pressing issues facing Georgia residents.
Proponents of a strong two-party state government ought to be jubilant at the outcome of Georgia's Feb. 5 presidential primary.
As a teenager on a sweltering August day in 1963, I stood among 250,000 on the National Mall in Washington, D.C., and listened as a fellow son of Georgia described a dream he had.
This Valentine's Day I celebrated "I Love Mountains Day." I delivered valentines to politicians who keep allowing King Coal to cut the heads off the oldest mountains in the world.
The 2008 Georgia General Assembly session is in mid-stream as we have completed its 14th day (Friday).
Recently, Dr. James Dobson came out publicly and stated that if Arizona Sen. John McCain carries the Republican nomination for the presidency he would not cast a vote in the 2008 presidential election.
So far, watching Georgia politics in 2008 has been like having a ringside seat at a professional wrestling match. Legislating sound laws and presenting calm and prudent budget plans have been replaced by threatened body slams and real flying chairs.
The Senate was hard at work again this week, boldly tackling difficult issues facing our state. One of the issues at the top of that list is transportation.
Liberty County students and property taxpayers could see some much-needed help under a tax relief bill introduced in the House of Representatives last week.
I have the distinguished honor of endorsing Gov. Mike Huckabee as the candidate to become the Republican nominee and the next president of the United States. He has extensive leadership experience, and he possesses strong Christian conservative values. He is dedicated to promoting personal responsibility, and believes in less government, less taxes and empowering the family. He is the Republican that I trust with the future of our country.
This week, Georgia House Democrats announced two legislative proposals that would put a stop to school funding cuts and relieve the burden of nearly $1.6 billion in tax shifts from local property owners. The plans provide fiscally sound property tax relief by fully funding the Quality Basic Education (QBE) Act.
Make no mistake about it, the central economic problem facing the United States is out-of-control federal spending and the massive federal debt that continues to pile up.
I want you to hear this from me rather than from Donald Trump. I have been outed. I am a "bed-wetting liberal." No longer can ...
Georgia is a state where we measure ourselves by how other people think of us.
I was hired Nov. 13, 1983, as chief deputy clerk of the Office of the Clerk of Courts of Liberty County, having served previously for ...
My husband is like a relentless teenager. When he wants something, he persists until it's easier for me to say "yes" just to get ...
Editor, In March, I wrote in to express my horror at the prospect of the Riceboro mayor and City Council voting themselves healthy raises (more ...
Editor, I am really tired of all of the "political correctness," especially concerning the Confederate battle flag.
Usually, when we picture streams, we are thinking more of a pastoral landscape.
With the legalization of fireworks this year, Georgia residents had a blast over the Fourth of July weekend - literally.
With the state's Solar Power Free Market Financing Act now law, Georgia is expected to have a banner year for new solar installations in ...
Blessed are we, the peacemakers. Ours is a lonely lot. I had hoped I could cut back on pacifying petulant poops and spend more time ...
As the self-proclaimed Islamic State, also known by the acronym ISIL, continues to grow and advance in the Middle East and even in our homeland ...
My sister and I stood in the charred remains of a life that once was and said not a word. What was there to say ...
Editor, Regarding the Confederate battle flag, Tom Crawford gets it mostly wrong in his opinion piece in the Coastal Courier of July 15.
One of the most important statutory jobs that the clerk of superior court has is custodianship of the county's jury lists. Ultimately, the clerk ...
Using medicines safely includes proper disposal of them.
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Toby Hede
Is the CVS source the best place to get started? I have d/l it and compiled it, but the API has obviously changed compared to that documented on the jdbm site itself.
Also, what is the difference between the HTree and the BTree stuff? The older version is a little bit simpler, so I am not sure which is the 'official' one to use.
Alex Boisvert
Yes, CVS is the best place to start. You can grab the latest code from the home page, actually.
The CVS version contains some bug fixes as well as refined APIs. Those APIs will form the basis of the 1.0 version.
I will update the site shortly (javadoc & examples)
Alex Karasulu
Alex this gives me the opportunity to ask if you will be releasing again anytime soon?
Another Alex
Alex Boisvert
I will release a 1.0RC1 (release candidate) before Sept. 1st and if everything goes well, a final 1.0 version by October 1st.


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South Africa Newswire
Comprehensive Real-Time News Feed for South Africa.
Results 1 - 20 of 11,794 in South Africa
Miami Heat's Luol Deng stars in NBA Africa game w/Photo
Luol Deng scored 20 points and took home co-MPV honors with Chris Paul during Saturday's NBA Africa game in Johannesburg, South Africa. Deng captained Team Africa, which fell to Team World 101-97, for the NBA's first exhibition game on the African continent. Comment?
.com | Fuel tanker crash causes massive blaze on Durban highway w/Photo
A diesel and petrol tanker have crashed on the N2 northbound at the Sarnia road overhead bridge between the Chatsworth offramp and Queensburgh in Durban, causing a massive fire, KwaZulu-Natal Emergency Medical Services said early on Tuesday. "The KZN EMS paramedics on scene have reported that the two people are being treated for minor injuries," said McKenzie. Comment?
Charlize Theron steps out with son Jackson for first time since it... w/Photo
He's a big brother now! Charlize Theron steps out with son Jackson for first time since it emerged she has adopted a little girl Charlize Theron and her son Jackson have been spotted for the first time since it emerged a new member has joined their family. Big brother: Charlize Theron and her son Jackson have been spotted for the first time since it emerged a new member has joined their family According to TMZ , the South African beauty took custody of the African-American tot last month, after working with with a US adoption agency for six months. Comment?
Hatemongers on social media to Idaho huntress: Kill yourself w/Photo
Sabrina Corgatelli, a huntress who is believed to hail from Boise, Idaho, sparked a flood of hate from anti-hunters on social media with pictures of animals she shot, the UK Telegraph reported Monday. Aislinn Laing, reporting from Johannesburg, South Africa, said the hatred was in response to photos she posted with corpses of a giraffe, warthog, kudu and impala she shot during a trip to South Africa. Comment?
Cricket writer Peter Roebuck inquest set to be reopened : August 04, 2015, w/Photo
SYDNEY: An inquest into the apparent suicide of renowned cricket writer Peter Roebuck in South Africa four years ago is set to be reopened, his former employer reported on Monday. English-born Roebuck, 55, was covering the Test series between South Africa and Australia in 2011 when he plunged to his death from the Southern Sun Hotel in Cape Town. Comment?
Bayer supports Prevention of Blindness Photo Competition
... Council meetings and all winners will be part of a Photo Exhibition at IAPB's 10th General Assembly in Durban, South Africa in 2016. Photo submissions that showcase the theme 'Eye care for all' can also be tagged with a number of sub-themes, like ... Comment?
Top Takeaways from the NBA's First-Ever Africa Game
The NBA hosted its first exhibition game in Africa this past Saturday. Team World overcame a fourth-quarter deficit to defeat Team Africa 101-97. There were some familiar faces suiting up in Johannesburg, South Africa. Basketball fans were pleasantly surprised to see legends Hakeem Olajuwon and Comment?
Frans Steyn released from Springboks squad following his brother's death w/Photo
Reports in South Africa said that Steyn's brother Wimpie took his own life on their family farm on Monday morning. Steyn has been training with the Springboks in Durban. Comment?
Another South African flag to fly w/Photo
... was erected, plans are in place for another flag to be added to the avenue. The flag representing present day South Africa will be flown alongside the other flags on Bombala Street following talks between the South African High Commission and ... Comment?
Delta Air Lines bans animal hunting trophies after Cecil the Lion shooting w/Photo
... supporting legal shipments." The airline offers a nonstop 15 hour flight from Atlanta to Johannesburg, South Africa's largest city. Delta Air Lines carried 129 million passengers in 2014, the most out of all U.S. carriers, according to the U.S. ... Comment?
Alleged drug-fueled murderer of American woman in South African... w/Photo
... member of billionaire Central American dynasty Gabriele Kabrins, 39, was found dead in hotel room in Camps Bay, South Africa, near Cape Town, where she had been brutally sexually assaulted He was also charged with possession of more than 1lb of ... Comment?
HARD Summer 2015: Jack Black joins Die Antwoord on last day of festival w/Photo
Actor Jack Black performs with Die Antwoord at HARD Summer Music Festival at Fairplex in Pomona on Sunday, August 2, 2015. POMONA >> During Die Antwoord's Sunday set at HARD Summer's HARDer stage, comedian Jack Black surprised fans when he came out on stage with the South African group. Comment?
Wynne Gray's 50 greatest rugby moments: No.45 w/Photo
The All Blacks went through a series of SAS sessions before the 1999 tournament and four years later the Springboks were put through the shame of Kamp Staaldraad in preparation for the tournament. The Springbok squad had been named but coach Rudi Straeuli suggested to them that Camp Barbed Wire would confirm places for the trip to Australia. Comment?
New Documentary to Explore South Africa's Political and Social... w/Photo
... producer Nisa Ahmad is making it her duty to bring Generation Soweto to life. After taking a personal trip to South Africa earlier this year and spending a number of days in Cape Town and Johannesburg, Ahmad knew she had to document her experience. ... Comment?
.com | Baby, three adults airlifted to hospital in Gauteng crashes w/Photo
Johannesburg A 10-month-old baby and three adults were airlifted to various hospitals on Monday following three separate accidents in Gauteng, paramedics said. The baby was among a group of people injured when their minibus taxi overturned on the N1 south in Midrand in the evening, Netcare 911 spokesperson Santi Steinmann said. Comment?
.com | Serious discussion on gun, police laws needed - Zuma w/Photo
In the wake of more than 50 police officers killed since the beginning of 2015, a serious discussion was needed on the laws governing guns in South Africa, as well as how the police protect themselves, President Jacob Zuma said on Monday. Zuma was speaking to media in Katlehong, where he visited a gathering of families of slain police officers, including that of Johannesburg metro police officer Simon Mabatamela. Comment?
Chenin Blanc, Grenache Blanc for something different - " Wine Buy w/Photo
... for Sauvignon Blanc. Branch out and try Chenin Blanc or Grenache Blanc. Chenin Blanc is a French grape, and South Africa has become huge producer for it. It is fairly similar to Pinot Gris, and can be fruit-forward and lean on the dry side. Jancis ... Comment?
Cape Town Scot murder accused's trial fitness doubt w/Photo
Congratulations, you're now registered! Let us know what news and updates you want to hear about and we'll send them straight to your inbox. A TEENAGER accused of the violent murder of a Scots expat pensioner in South Africa could be unfit to stand trial. Comment?
If Test cricket does suffer 'Death of a Gentleman', suicide is most likely verdict w/Photo
The new film 'Death of a Gentleman' set out to discover if Twenty20 might kill Test cricket, but found bigger threats at play Highveld Lions players celebrate2 their win during the Karbonn Smart CLT20 match between Chennai Super Kings and Highveld Lions at Sahara Park Newlands on October 16, 2012 in Cape Town, South Africa Sam Collins and Jarrod Kimber's investigation into the future of Test cricket is not yet due to be screened north of York, but a few tweets were all the encouragement Collins needed to look into bringing it to the North East, so hopefully that will change soon. Comment?
Sudan's Bashir says determined to reach negotiated solution to Two Areas conflict w/Photo
The Sudanese president Omer Hassan al-Bashir on Monday has discussed with the African Union chief mediator, Thabo Mbeki, the recent developments of the peace process and national dialogue besides relations between the two Sudans. Former South African President Thabo Mbeki meets with Sudanese President Omer al-Bashir at the new Presidential palace in Khartoum on August 3, 2015 Sudan's presidential assistant, Ibrahim Mahmoud Hamid, told reporters that Bashir stressed to the African Union mediator that his government is seriously seeking to end the conflict in South Kordofan and Blue Nile states through negotiations. Comment?
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