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1. BMC Medical Genetics BioMed Central Case report Open Access Association of a de novo 16q copy number variant with a phenotype that overlaps with Lenz microphthalmia and Townes-Brocks syndromes Tanya M Bardakjian1, Adele S Schneider1, David Ng2, Jennifer J Johnston2 and Leslie G Biesecker*2 Address: 1Clinical Genetics, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA and 2National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA Email: Tanya M Bardakjian - firstname.lastname@example.com; Adele S Schneider - firstname.lastname@example.com; David Ng - email@example.com; Jennifer J Johnston - email@example.com; Leslie G Biesecker* - firstname.lastname@example.com * Corresponding author Published: 16 December 2009 Received: 19 May 2009 Accepted: 16 December 2009 BMC Medical Genetics 2009, 10:137 doi:10.1186/1471-2350-10-137 This article is available from: http://www.biomedcentral.com/1471-2350/10/137 © 2009 Bardakjian et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Anophthalmia and microphthalmia are etiologically and clinically heterogeneous. Lenz microphthalmia is a syndromic form that is typically inherited in an X-linked pattern, though the causative gene mutation is unknown. Townes-Brocks syndrome manifests thumb anomalies, imperforate anus, and ear anomalies. We present a 13-year-old boy with a syndromic microphthalmia phenotype and a clinical diagnosis of Lenz microphthalmia syndrome. Case Presentation: The patient was subjected to clinical and molecular evaluation, including array CGH analysis. The clinical features included left clinical anophthalmia, right microphthalmia, anteriorly placed anus with fistula, chordee, ventriculoseptal defect, patent ductus arteriosus, posteriorly rotated ears, hypotonia, growth retardation with delayed bone age, and mental retardation. The patient was found to have an approximately 5.6 Mb deletion of 16q11.2q12.1 by microarray based-comparative genomic hybridization, which includes the SALL1 gene, which causes Townes-Brocks syndrome. Conclusions: Deletions of 16q11.2q12.2 have been reported in several individuals, although those prior reports did not note microphthalmia or anophthalmia. This region includes SALL1, which causes Townes-Brocks syndrome. In retrospect, this child has a number of features that can be explained by the SALL1 deletion, although it is not clear if the microphthalmia is a rare feature of Townes-Brocks syndrome or caused by other mechanisms. These data suggest that rare copy number changes may be a cause of syndromic microphthalmia allowing a personalized genomic medicine approach to the care of patients with these aberrations. Background 10,000 births [1-4]. The A/M spectrum may be isolated or Anophthalmia and microphthalmia (A/M) are part of a syndromic and is etiologically and clinically heterogene- spectrum of ocular anomalies that includes coloboma. ous with substantial phenotypic overlap in many cases. These conditions have a combined incidence of about 2/ This makes accurate syndrome identification crucial in Page 1 of 7 (page number not for citation purposes)
BMC Medical Genetics 2009, 10:137 http://www.biomedcentral.com/1471-2350/10/137 order to provide families and individuals with appropri- an in utero ischemic event. A CT scan of the orbits at 6 days ate recurrence risk counseling. of age showed some orbital contents in the right eye with an abnormal lens and soft tissue overlying the globe, and One-third of individuals with A/M have associated mal- his clinical diagnosis was modified to left clinical anoph- formations [4]. Both genetic and environmental causes of thalmia and right microphthalmia. The left globe had a A/M have been noted. Mutations causing a phenotype small oval focus of soft tissue, but this tissue could not that segregates in an autosomal recessive pattern have confidently be determined to be optic. The optic nerves been found in PAX6 [5], RAX [6] and CHX10 [7] (MIM appeared severely hypoplastic. A cranial MRI done at 7 607108, 601881 and 142993, respectively). Mutations in days of age identified absent optic nerves with a small SOX2 (MIM 184429) [8,9] were recently described in optic chiasm. Renal ultrasound at 2 days of age showed individuals with A/M that segregates in an autosomal the kidneys measured 3.7 cm bilaterally (normal 4.0-6.0 dominant pattern. Current estimates suggest that up to cm). Echocardiogram identified a small ventriculoseptal 15% of individuals with bilateral A/M have a mutation in defect and patent ductus arteriosus, which both resolved SOX2 [9]. Bakrania et al., [10] also found individuals with spontaneously. He was also noted to have an anteriorly deletions of SOX2. Mutations in OTX2 (MIM 600037) placed anus with a fistula that was corrected surgically at have been reported in up to 5% of individuals with A/M 2 months of age. [9]. Mutations in BCOR (MIM 300485) have been seen in families with X-linked recessive inheritance of a pheno- Clinical Genetics evaluation was performed at 5 years 9 type strikingly similar to Lenz microphthalmia syndrome months by one of the authors. Additional history at the [11,12]. Lenz microphthalmia has cardinal manifesta- time of this evaluation showed he failed to meet multiple tions of microphthalmia, growth retardation and limb developmental milestones. His height was 102 cm (<<5th anomalies [13]. Other malformations thought to be typi- centile; 50th centile for 4 years), weight 29.5 pounds cal of this disorder include microcephaly, cognitive (<<5th centile; ~50th centile for 2 years 6 months), and impairment, protuberant ears, missing upper central inci- head circumference was 50 cm (10-25th centile). In addi- sors, syndactyly, and a cylindrical thorax with sloping tion to the findings described above, he was found to have shoulders. However, it is clear that Lenz microphthalmia apparently small, overfolded, and cupped ears, long trunk is clinically variable and genetically heterogeneous and with narrow shoulders, low set thumbs, and partial cuta- prior data show that phenotypes compatible with this neous syndactyly of toes 4-5. Peripheral blood karyotype description map both to Xp and Xq, the former caused by was performed at the referring institution and was mutations in the BCOR gene (MIM 309800) which causes reported as normal, 46,XY. The patient was diagnosed a phenotype that overlaps extensively with Lenz microph- with Lenz microphthalmia syndrome (OMIM 309800 thalmia, and shares the X-linked inheritance pattern in MCOPS1). Complete sequencing of coding exons and two families [12,14]. The Xq Lenz locus (MCOPS1 MIM flanking introns of BCOR (the single known Lenz syn- 309800) has not yet been identified [15]. drome gene) was normal (data not shown). Here we report a patient with syndromic A/M that over- He was recently re-evaluated at the age of 13 years. He was laps with Lenz microphthalmia syndrome (MIM treated with melatonin to help with his sleep cycle. On 309800). Molecular evaluation of this patient showed a examination, his weight was 65 lbs (<<5th centile; ~50th deletion of 16q, which includes the SALL1 gene, which centile for 9 year old), Height 57 in (~10th centile) and causes Townes-Brocks syndrome (TBS, MIM 107480). head circumference 52.5 cm (~10th centile). In addition to This finding extends the notion of etiologic heterogeneity the previously mentioned findings, he had multiple nevi of syndromic microphthalmia and has implications for on his chest, back, and limbs. All were 0.3 cm or less. He the approach to molecular diagnostics for this disorder. has made developmental progress but is in special educa- tion. Sequencing of SOX2 was normal (data not shown). Case Presentation The patient was born at full term weighing 6 lb 2 oz (~25th The array platform was of the oligonucleotide CGH type centile) and length was 21 in (~75th centile). He was with average genome spacing of 37 kb and targeted probes apneic at birth and was intubated and transferred to the in candidate gene regions with 5-20 kb probe spacing (for NICU. He was weaned from the ventilator at 7 days of age details see http://www.genedx.com/site/genomedx). with no complications. Bilateral clinical anophthalmia Hybridization was performed on DNA isolated from was diagnosed on clinical examination. A cranial CT scan peripheral blood leukocytes as previously described [16]. at one day of age showed mild prominence of the left lat- This assay identified an approximately 5.6 Mb deletion of eral ventricle. A small cavum septum pellucidum was also chromosome 16. The deletion likely has a minimum noted. A focal area of parenchymal lucency was noted in boundary size of Chr16:45,018,886 - 50,571,154 the left parietal parenchyma. This raised the possibility of (Human Genome Build 36) and includes 26 known genes Page 2 of 7 (page number not for citation purposes)
BMC Medical Genetics 2009, 10:137 http://www.biomedcentral.com/1471-2350/10/137 (Table 1). This deletion was not present in the parents. The deleted region in the patient reported here includes The deletion of SALL1 was confirmed by a MLPA assay 26 genes, including three recognized disease-causing using the SALSA MLPA kit P180 (MRC Holland, data not genes (Table 1). This list includes the SALL1 gene, which shown). Assessment of 6 STRP markers on chromosome when mutated causes Townes-Brocks syndrome [18]. 16 showed inheritance of alleles consistent with biologic Individuals with whole gene deletions have a milder phe- parentage. The proband is apparently homo/hemizygous notype than those who have dominant negative point at marker D16S3396 (Chr16:49,749,809 - 49,750,146) mutations [19]. The classic phenotype for TBS includes and does not share an allele with the mother suggesting imperforate anus, dysplastic ears with hearing impair- the deletion occurred on the maternal chromosome. We ment, and thumb malformations, although many affected conclude that this variant is de novo in the proband. patients do not have the typical phenotypic features. Less frequent manifestations of TBS include renal, heart, foot, Conclusions and genitourinary anomalies, and mental retardation. We report a boy with microdeletion of 16q11.2q12.1 This patient has a number of phenotypic manifestations identified by array CGH. Microdeletion of 16q11.2q12.2 that are not typical of TBS including A/M, cognitive has been reported as an emerging microdeletion syn- impairment, borderline small head size, growth retarda- drome [17]. That report includes two patients with micro- tion, abnormal body habitus, and relatively normal deletions of 16q that overlap the deletion seen in the thumbs. According to Kohlhase, the clinical diagnosis of patient reported here. All three patients share similar cen- TBS requires two of: tromeric endpoints (as defined by the last centromeric oli- gonucleotide detected as a single-copy) and two of the * Imperforate anus three patients share similar telomeric endpoints. The dele- tion in Patient 1 in Ballif et al [17] extended an additional * Dysplastic ears (overfolded superior helices, microtia) 1.4 Mb towards the telomere when compared to the present patient. Other patients with deletions of * Typical thumb malformations (preaxial polydactyly, 16q11q12 have been reported with limited molecular triphalangeal thumbs, hypoplastic thumbs) without data (Table 2). shortening of the radius http://www.ncbi.nlm.nih.gov/ sites/GeneTests/?db=GeneTests Table 1: Genes in the deleted region Gene Name Description Transcription Start SHCBP1 SHC SH2-domain binding protein 1 45,171,968 VPS35 vacuolar sorting protein 35 45,251,089 ORC6L origin recognition complex subunit 6 45,281,058 MYLK3 myosin light chain kinase 3 45,293,694 GPT2 alanine aminotransferase 2 45,476,602 DNAJA2 DnaJ subfamily A member 2 45,546,774 NETO2 neuropilin- and tolloid-like protein 2 45,672,942 ITFG1 integrin alpha FG-GAP repeat containing 1 45,746,798 PHKB phosphorylase kinase, beta isoform a 46,052,710 ABCC12 ATP-binding cassette protein C12 46,674,384 ABCC11 ATP-binding cassette protein C11 46,758,322 LONP2 peroxisomal LON protease-like 46,835,711 SIAH1 seven in absentia homolog 1 isoform a 46,951,946 N4BP1 Nedd4 binding protein 1 47,130,137 CBLN1 cerebellin 1 precursor 47,869,711 ZNF423 zinc finger protein 423 48,082,021 TMEM188 transmembrane protein 188 48,616,689 HEATR3 HEAT repeat containing 3 48,657,381 PAPD5 PAP associated domain containing 5 48,745,568 ADCY7 adenylate cyclase 7 48,879,323 BRD7 Bromodomain containing 7 48,910,441 NKD1 naked cuticle homolog 1 49,139,741 SNX20 sorting nexin-20 49,257,711 NOD2 nucleotide-binding oligomerization domain 49,288,550 CYLD ubiquitin carboxyl-terminal hydrolase CYLD 49,333,461 SALL1 sal-like 1 49,727,386 Page 3 of 7 (page number not for citation purposes)
Table 2: Summary of patients with proximal 16 deletions. Page 4 of 7 (page number not for citation purposes) http://www.biomedcentral.com/1471-2350/10/137 Patient Chromosomal Methodology Molecular Hand/Foot Anal Low Set/ Growth Hypotonia MR/DD Region deletion malformation Malformations Dysmorphic Retardation (minimal) Ears Present Case 16q11.2q12.1 oligonucleotide Chr16: Low-set thumbs, + + + + + aCGH 45,018,886 -- partial 4,5 toe 50,571,154 syndactyly 1A 16q11.1q12.1 550 band ND Proximally placed - + - - + karyotype thumbs, short distal phalanges 1B 16q11.1q12.1 550 band ND Proximally placed - + + - + (sister of 1A) karyotype thumbs, short distal phalanges 2 16q11.2q21 CGH/FISH Chr16:49,728,524 Radial hypoplasia, + + - NA NA -62,004,665 preaxial (YAC 922f01- polydactyly, PAC malpositioned LLNLP704M0311 toes 26Q4) 3A 16q11.2q12.2 oligonucleotide chr16:45,058,042- Malpositioned - + - + + aCGH 52,009,874 toes, syndactyly 3B 16q11.2q12.2 oligonucleotide chr16:45,058,042- Malpositioned Rectal prolapse + - + + aCGH 50,485,941 toes 4 16q11.1q13 high resolution ND Malpositioned - + + + + karyotype toes 5,6 16q12.1q12.2 650 band chr16:49,028,856 Malpositioned - + + + + karyotype/ (D16S308) toes, long fingers deafness somatic cell hybrids 7 16q12.1q12.2 BAC aCGH/FISH chr16:50,271,170- Radial hypoplasia, - NA - + + 52,727,176 syndactyly (BAC RP11- 242n20-RP11- 324d17) 8 16q12.1q12.2 qPCR Chr16:47,900,000 Long thumbs + + - NA + -49,800,000 deafness BMC Medical Genetics 2009, 10:137 (approx.) 9A 16q12.1q13 850 band ND Malpositioned - + + + + karyotype toes, syndactyly, deafness small hands and feet 9B 16q12.1q13 850 band ND Malpositioned + + + + + twin of 9A karyotype toes, syndactyly, small hands and feet ND is not done, NA is not assessed, aCGH is array comparative genomic hybridization, BAC is bacterial artificial chromosome, FISH is fluorescence in situ hybridization, and qPCR is quantitative polymerase chain reaction. References for Case numbers: 1 Hoo et al. [30], 2 Knoblauch et al. [31], 3 Ballif et al. [16], 4 Krauss et al. [32], 5 Schuffenhauer et al [33], 6 Callen et al. [34] (this patient was described in two papers), 7 Matthaei et al. [35], 8 Borozdin et al. [18], 9 Elder et al. [36]
BMC Medical Genetics 2009, 10:137 http://www.biomedcentral.com/1471-2350/10/137 The present patient only has one of these manifestations associated with Brooke-Spiegler syndrome (MIM 605041) and therefore does not meet these stringent clinical crite- [26]. Missense mutations in NOD2 cause Blau syndrome ria, though as noted above, the phenotype is acknowl- and an increased susceptibility to Crohn's disease (MIM edged to be variable. One may speculate that an anterior- 266600) [27]. Blau syndrome is inherited in an auto- placed anus with a fistula is reminiscent of TBS, however somal dominant pattern and characterized by early-onset it does not formally meet the criteria. granulomatous arthritis, rashes, and camptodactyly. Ocu- lar manifestations include uveitis, glaucoma, retinal In contrast, the classical manifestations of Lenz microph- detachment, and cataract [28,29]. No published reports of thalmia are microphthalmia, growth retardation, and ear A/M and Blau syndrome were identified (negative results anomalies, all of which this patient manifested [13]. from PubMed using the two search strings: "anophth* Clearly, this triad is not specific for Lenz microphthalmia AND Blau" and "microphth* AND Blau"). and it is reported that > 90% have cognitive impairment [20], as seen in the present patient. A variety of skeletal Heterozygous loss of function mutations in CYLD cause and limb manifestations have been reported, although Brooke-Spiegler syndrome, which is characterized by a frequency data are not available. number of rare skin appendage tumors such as cylin- droma, trichoepithelioma, and spiradenoma [30]. Early Although some of the clinical features of the present detection and aggressive treatment can prevent the signif- patient overlap with the patients previously reported with icant deformity that can be caused by these tumors. These 16q11.2 deletions and patients with TBS, the patient data suggest that the molecular delineation of this dele- reported here had a major anomaly, A/M, which is clearly tion in this patient present an opportunity to provide pre- atypical for either of these molecular lesions. Microph- symptomatic care that will significantly ameliorate the thalmia has been reported in a pair of twins with TBS and morbidity of this syndrome. a point mutation in SALL1 [21] and a patient from the pre-molecular era with a clinical phenotype consistent The patient reported here shares some clinical findings with TBS [22]. There are several possible hypotheses to with the two previously reported patients [17] with dele- explain this observation. First, it is possible that A/M is a tion 16q11.2;12.2 namely; ear anomalies, toe abnormali- very uncommon manifestation of TBS. Insofar as the ties, hypotonia, and significant developmental delay. twins reported by Botzenart et al are concerned, it is Interestingly, Patient 2 from Ballif et al., [17] was reported remarkable that although both twins had unilateral to have scattered pigmentary nevi, which was also found microphthalmia, neither their TBS-affected siblings nor in the patient reported here. their TBS-affected father had microphthalmia. It is reported that microphthalmia is two to five times more We conclude from these data that the pleiotropic syn- common in twins than in singletons [23,24], which limits drome in this patient is caused by the deletion, which was the utility of this case in assigning causality of the micro- detected by array CGH. The phenotype in this patient has phthalmia in this pair of twins to the SALL1 mutation. some similarities to Townes-Brocks syndrome and to Lenz Second it is possible that the deleted region in the patient microphthalmia. The other suggestion from this report is reported here includes a gene, that when deleted, leads to that array CGH analysis should be considered in all A/M but with reduced penetrance. The prior report of a patients with syndromic A/M. This is in addition to previ- single patient with the co-occurrence of TBS and microph- ous recommendations that such patients undergo chro- thalmia is intriguing [22] in this regard. As this patient has mosome analysis and SOX2 mutation analysis [9,10]. not be characterized molecularly and is now deceased (A.R. Cooper, personal communication), we cannot List of abbreviations determine if that child had microphthalmia and TBS A/M: anophthalmia or microphthalmia; CGH: compara- because of a 16q deletion or that s/he had a point muta- tive genomic hybridization; aCGH: array CGH; TBS: tion in SALL1 and microphthalmia is a rare manifestation Townes Brocks syndrome; of TBS. The third possibility is that in the present patient and the patient reported by Fraser and Cooper, [22] the Consent 16q11.2q12.2 deletion is in trans with another variant, The parent of this minor patient has given written consent likely to be uncommon, that leads to a null for a putative for the report to be published. The patient was also con- A/M gene in this interval. It will be important to analyze sented to a clinical research protocol reviewed and additional cases with deletions of this region to distin- approved by the NHGRI IRB. guish these two hypotheses. Competing interests The deletion region also includes the genes NOD2 associ- The authors declare that they have no competing interests. ated with Blau syndrome (OMIM 266600) [25] and CYLD Page 5 of 7 (page number not for citation purposes)
BMC Medical Genetics 2009, 10:137 http://www.biomedcentral.com/1471-2350/10/137 Authors' contributions 11. Hilton E, Johnston J, Whalen S, Okamoto N, Hatsukawa Y, Nishio J, Kohara H, Hirano Y, Mizuno S, Torii C, et al.: BCOR analysis in TMB wrote the first draft of the manuscript. ASS and DN patients with OFCD and Lenz microphthalmia syndromes, examined the patient and edited the manuscript. JJJ mental retardation with ocular anomalies, and cardiac later- designed, interpreted, and performed some of the molec- ality defects. European Journal of Human Genetics 2009. 12. Ng D, Thakker N, Corcoran CM, Donnai D, Perveen R, Schneider A, ular evaluations, reviewed the literature, and wrote signif- Hadley DW, Tifft C, Zhang L, Wilkie AO, Smagt JJ van der, Gorlin RJ, icant portions of the manuscript. LGB designed and Burgess SM, Bardwell VJ, Black GC, Biesecker LG: Oculofaciocardi- interpreted some of the molecular evaluations, examined odental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. Nat Genet 2004, the patient, and wrote significant portions of the manu- 36:411-416. script. All authors have reviewed and approved the sub- 13. Jones KL: Smith's Recognizable Patterns of Human Malformation 6th edi- tion. Philadelphia: Elsevier Saunders; 2006. mission of the manuscript. 14. Hilton E, Johnston J, Whalen S, Okamoto N, Hatsukawa Y, Nishio J, Kohara H, Hirano Y, Mizuno S, Torii C, et al.: BCOR analysis in Acknowledgements patients with OFCD and Lenz microphthalmia syndromes, mental retardation with ocular anomalies, and cardiac later- Funding for ASS and TMB was provided by the Albert B. Millett Memorial ality defects. European Journal of Human Genetics 2009, Fund, A Mellon Mid-Atlantic Charitable Trust, Rae S. Uber Trust, and the 17:1325-1335. Gustavus and Louise Pfeiffer Research Foundation. Funding for JJJ, DN, and 15. Graham CA, Redmond RM, Nevin NC: X-linked clinical anoph- LGB was provided by the Intramural Research Program of the National thalmos. Localization of the gene to Xq27-Xq28. Ophthalmic Paediatr Genet 1991, 12:43-48. Human Genome Research Institute of the National Institutes of Health. 16. Piton A, Michaud JL, Peng H, Aradhya S, Gauthier J, Mottron L, Cham- The authors are grateful to the family for their support of this description pagne N, Lafreniere RG, Hamdan FF, Joober R, Fombonne E, Mari- of their son and their support of the International Anophthalmia Children's neau C, Cossette P, Dube MP, Haghighi P, Drapeau P, Barker PA, Network. Aradhya Swaroop, Ph.D., of GeneDx Corp. provided informa- Carbonetto S, Rouleau GA: Mutations in the calcium-related tion on the array platform. gene IL1RAPL1 are associated with autism. Human Molecular Genetics 2008, 17:3965-3974. 17. Ballif BC, Theisen A, McDonald-McGinn DM, Zackai EH, Hersh JH, References Bejjani BA, Shaffer LG: Identification of a previously unrecog- 1. Clementi M, Tenconi R, Bianchi F, Botto L, Calabro A, Calzolari E, nized microdeletion syndrome of 16q11.2q12.2. Clinical Genet- Cianciulli D, Mammi I, Mastroiacovo P, Meli P, Spagnolo A, Turolla L, ics 2008, 74:469-475. Volpato S: Congenital eye malformations: a descriptive epide- 18. Kohlhase J, Wischermann A, Reichenbach H, Froster U, Engel W: miologic study in about one million newborns in Italy. Birth Mutations in the SALL1 putative transcription factor gene Defects Orig Artic Ser 1996, 30:413-424. cause Townes-Brocks syndrome. Nature Genetics 1998, 2. Kallen B, Robert E, Harris J: The descriptive epidemiology of 18:81-83. anophthalmia and microphthalmia. Int J Epidemiol 1996, 19. Borozdin W, Steinmann K, Albrecht B, Bottani A, Devriendt K, 25:1009-1016. Leipoldt M, Kohlhase J: Detection of heterozygous SALL1 dele- 3. 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Nature Genetics 2001, 29:19-20. description of the syndrome associated with visible chromo- 26. Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, some deletions of this region. European Journal of Human Genetics Green H, Brown C, Biggs PJ, Lakhani SR, Jones C, Hansen J, Blair E, 2002, 10:807-812. Hofmann B, Siebert R, Turner G, Evans DG, Schrander-Stumpel C, 9. Ragge NK, Lorenz B, Schneider A, Bushby K, de Sanctis L, de Sanctis Beemer FA, Ouweland A van Den, Halley D, Delpech B, Cleveland U, Salt A, Collin JR, Vivian AJ, Free SL, Thompson P, Williamson KA, MG, Leigh I, Leisti J, Rasmussen S: Identification of the familial Sisodiya SM, van Heyningen V, Fitzpatrick DR: SOX2 anophthalmia cylindromatosis tumour-suppressor gene. Nature Genetics syndrome. Am J Med Genet A 2005, 135:1-7. discussion 8. 2000, 25:160-165. 10. Bakrania P, Robinson DO, Bunyan DJ, Salt A, Martin A, Crolla JA, 27. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Wyatt A, Fielder A, Ainsworth J, Moore A, Read S, Uddin J, Laws D, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot Pascuel-Salcedo D, Ayuso C, Allen L, Collin JR, Ragge NK: SOX2 A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, anophthalmia syndrome: 12 new cases demonstrating Colombel JF, Sahbatou M, Thomas G: Association of NOD2 leu- broader phenotype and high frequency of large gene dele- cine-rich repeat variants with susceptibility to Crohn's dis- tions. Br J Ophthalmol 2007, 91:1471-1476. ease. Nature 2001, 411:599-603. Page 6 of 7 (page number not for citation purposes)
BMC Medical Genetics 2009, 10:137 http://www.biomedcentral.com/1471-2350/10/137 28. Blau EB: Familial granulomatous arthritis, iritis, and rash. J Pediatr 1985, 107:689-693. 29. Pastores GM, Michels VV, Stickler GB, Su WP, Nelson AM, Boven- myer DA: Autosomal dominant granulomatous arthritis, uveitis, skin rash, and synovial cysts. J Pediatr 1990, 117:403-408. 30. Scheinfeld N, Hu G, Gill M, Austin C, Celebi JT: Identification of a recurrent mutation in the CYLD gene in Brooke-Spiegler syndrome. Clin Exp Dermatol 2003, 28:539-541. 31. Hoo JJ, Lowry RB, Lin CC, Haslam RH: Recurrent de novo inter- stitial deletion of 16q in two mentally retarded sisters. Clinical Genetics 1985, 27:420-425. 32. Knoblauch H, Thiel G, Tinschert S, Korner H, Tennstedt C, Chaoui R, Kohlhase J, Dixkens C, Blanck C: Clinical and molecular cytogenetic studies of a large de novo interstitial deletion 16q11.2-16q21 including the putative transcription factor gene SALL1. Journal of Medical Genetics 2000, 37:389-392. 33. Krauss CM, Caldwell D, Atkins L: Interstitial deletion and ring chromosome derived from 16q. Journal of Medical Genetics 1987, 24:308-312. 34. Schuffenhauer S, Callen DF, Seidel H, Shen Y, Lederer G, Murken J: De novo interstitial deletion 16(q12.1q13) of paternal origin in a 10-year-old boy. Clinical Genetics 1992, 42:246-250. 35. Callen DF, Eyre H, Lane S, Shen Y, Hansmann I, Spinner N, Zackai E, McDonald-McGinn D, Schuffenhauer S, Wauters J, et al.: High reso- lution mapping of interstitial long arm deletions of chromo- some 16: relationship to phenotype. Journal of Medical Genetics 1993, 30:828-832. 36. Matthaei A, Werner W, Gerlach EM, Koerner U, Tinschert S, Nitz I, Herr A, Rump A, Bartsch O, Hinkel KG, Schrock E, Oexle K: Small reciprocal insertion detected by spectral karyotyping (SKY) and delimited by array-CGH analysis. Eur J Med Genet 2005, 48:328-338. 37. Elder FF, Ferguson JW, Lockhart LH: Identical twins with deletion 16q syndrome: evidence that 16q12.2-q13 is the critical band region. Human Genetics 1984, 67:233-236. Pre-publication history The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2350/10/137/pre pub Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: BioMedcentral http://www.biomedcentral.com/info/publishing_adv.asp Page 7 of 7 (page number not for citation purposes)


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A Greenwich Village Habitue
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Historical Traveler Reviews A Greenwich Village Habitue New York City
Great, highly recomend
I highly recommend staying in an apartment as opposed to a hotel in New York. A real feeling of truly experiencing temporarily living in New York as opposed to just passing through. The apartment is not modern in its feel but much more in line with the brownstone building it's contained within - think antique shop rather than Ikea!
Within easy walking distance of Greenwich Village and a Metro stop, this provided an ideal mix. For non city dwellers, this was very much more homely/less hassled than staying around the skyscrapers however with a great mix of restaurants/bars within walking distance.
Another plus was the great heating - this combined with the 'cosy' atmosphere - meant we were very comfortable - even on the coldest day of the year!
The apartment owners were very helpful. Even to the stage of printing out places to go, maps, leaving the latest guide book and restaurant leaflets for you to peruse at your leisure. Great place to stay - which is just as well seeing as we were celebrating our engagement in New York!
We love it
This apartment is in a lovely neighbourhood with great restaurants, bars, delis and shops close by. It is on a quiet, residential street in Greenwich Village and you can easily walk to Soho and the trendy meatpacking district. The rooms are spotlessly clean and decorated and furnished beautifully which I think is really imporant, I cannot stand badly decorated hotel rooms - no worries about that here the rooms are gorgeous. Also the bed was really comfortable. The hosts, Matthew and Kevin, were welcoming and helpful. My husband and I are vegetarian and this neighbourhood has some excellent vegetarian and vegan restaurants. I unreservedly recommend this apartment and look forward to staying there again.
Feel like a real New Yorker!
We stayed in this wonderful apartment for our honeymoon and loved it. The location is perfect - you are just round the corner from the trendy Meatpacking District with its cool restaurants and shops and the nearest subway station is only a short walk away. The apartment has a good-sized lounge area with TV, a comfortable queen bed, a dining area, kitchen and small bathroom. It is spacious, clean and quiet. We met up with some friends one evening who were paying double the amount for a hotel room which was absolutely tiny and right in the thick of it with all the noise from the traffic. In contrast, you can truly relax in this apartment and feel like a real New Yorker. Highly recommended.
Just Like Home
This is by far the best bed and breakfast of its kind I've ever stayed in in New York. It is even better than it appears from its website. Large, spacious room, good closet space, great bathroom with lots of hot water and great water pressure, convenient kitchenette for light breakfasts--all this on a quiet floor with real "Rear Window" views. I've lived in Manhattan before and I can say this really does feel like home.
A perfectly charming place to stay in one of the greatest spots in the country. Plenty of places to dance and dine within blocks of the Habitue. For us the experience was like living in our own apartment nestled in a quiet part of the Village, yet, only a few blocks from the subway. Fantastic.
The Ultimate Find
Nestled on a quiet street in Greenwich Village, GV Habitue is a gem. My husband and don't really enjoy staying in hotels, especially the ones we can afford. I love to find unique rooms to stay in, as an alternative. This lovely apartment in an 1830's brownstone exceeded our expectations. The inkeepers, Matt and Kevin, were two of the nicest people we'd met in the city, and they are seriously committed to providing the cleanest, most comfortable environment you'll ever find at these prices. When we arrived, we thought the pictures on the website probably made it look a little better than it was. We were wrong. The pictures on their site absolutely reflect the character and beauty of of the rooms. We will definitely stay there, in the future, whenever we are in the city.
Greenwich Village Habitue
My best friend and I have just got back from a fantastic week in New York. We spent 3 nights at W Tuscany in Midtown which we thoroughly enjoyed but it wasnt until we got to the Greenwich Village Habitue for the remainder of our trip that we could truely relax into the New York life style. Firstly Greenwich Village is a much better place to stay if you want to feel like a New Yorker and experience a feeling of community that you wont find in Mid Town. There are plenty of restaurants, cafes, trendy lounge bars, delis/supermarkets and shops all within walking distance of Greenwich Village Habitue. Its located on the Meat Packing/ Greenwich village border. The apartment we stayed in was on the 2nd floor but felt like a home from home. The best thing is having your own apartment as opposed to a "room" in a hotel. It was lovely, very spacious and clean with all amenities and we were well looked after by Mathew and Kevin. Other reviews have described what the apartments feature and I would always just choose to stay here in future.
Best Hotel
My wife and I have stayed at many hotels in Manhattan, and this is by far the best, and we will be going back. Situated on a quiet street, more apartment than hotel, no noise at night from other guests or people living there. Only two short blocks from the Meatpacking District or West Village shops and restaurants with Dagostinos down the street. Large room, and perfect host. This place beats all others!
Great stay in Greenwich Village
What a great stay we had at the Greenwich Village Habitue. Perfeclty located near great restaurants and the subway, it is also in a very nice and safe neighborhood. The accomodations were outstanding. We had a great visit and would come back in a second.
Tom and Lee
We just came back from a weekend stay at Greenwich Village Habitue and were so impressed I had to write this review immediately. First of all, I can't believe the value we got for the money. Instead of a hotel room, we got a gorgeous and HUGE studio apartment filled with antiques, a kitchen, lovely bathroom and LOADS of closet space. Even a dining room! The establishment is a charming Greenwich Village townhouse with several cute, well appointed apartments. The bed was wonderful, new and firm, sheets were great quality, as were the towels, which were plentiful. Everything was so CLEAN, and I am picky. Lots of lamps and good lighting too, local calls are free, which you won't find in the hotels. The location was another plus, right off Greenwich Street, and a block away from the trendy Meatpacking District. We had bowls of cafe au lait for breakfast every morning at Pastis, dinner choices are endless, with Paradou, MEET, and so many others just two blocks away. Great people watching. We also had the best lunch ever at Tavern on Jane -- order the blue cheese burger and you will NOT be disappointed. The owners, Matt and Kevin, are incredibly nice and accomodating, and had LOADS of maps, menus, magazines and other printed material on NY ready for us. We travel extensively and I found this place to be one of the best places I have stayed, regardless of cost. Just one point to be aware of, the townhouse does not have an elevator. We were on the third floor, which was no problem for us.
TripAdvisor Reviews A Greenwich Village Habitue New York City
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Topdeck - USA & Canada Adventure
... arrive in the beautiful city of Toronto. We spent the afternoon exploring the Kensington Market which is a little like our West End, it was pretty cool. Dinner was Korean BBQ which was awesome! Day Six We stopped in for a quick breakfast at Whole Foods wish is similar to Starbucks then met up in the city centre for our walking tour with Jason from Urban Adventures. He took us on a fantastic journey through the city and shared some history as well as some awesome graffiti spots. After ...
Day 1: New York
WE DID: - drove with Moira & Nick to London Heathrow - flew from Heathrow to JFK New York City - took a "cab" to the apartment we're staying in, on the Upper East Side (the parents of an ex-colleague of James: they're very kind and we're very lucky!) - wandered along to Central Park just in time for the sunset, before stopping off for dinner locally and having an early night WE LOVED: - meeting our welcoming hosts and seeing the fabulous views from their apartment for the first ...
Washington to New York
... for a weeks travel on the metro ($30) and took the metro train (E line) to Jamaica then the air train to JFK airport to meet Mikaela. We were there waiting at one gate and she came out another gate and surprised us. Back to hotel via the air train and metro, then out to dinner at nearby pub. After dinner we walked to Time Square, which was as busy as ever, then back to hotel.
All things American ...
... accurately, as it is never quiet. It bustles continuously with traffic sounds, sirens, music and voices having conversations that go all day and all night. It is bigger than life and so very alive. Everyone you see appears to love their lot in life ... even the sanitation workers smile and whistle as they collect the piles of garbage from the sidewalks. The dogs being walked appear truly contented with their sidewalk strolls ...
The epic baggage debacle.
... look and simultaneously headed for their desk. On the 10 sec walk we discussed the chances of us getting on this flight and agreed slim to none would be about right. This flight too had been delayed for hours and the seats for our gate were packed. Here's the miracle we got on the flight at last call, while our would have been fellow passengers could just stand by wondering why in hell they themselves haven't at least asked the desk clerk, being the same airline, same destination. My ...

subset: commoncrawl


text:
Shepparton CBD to be revitalised
A run-down retail site in Vaughan St, Shepparton is to be redeveloped after a buyer for the site was found.DARREN LINTON June 23, 2012 4:26am
The derelict Vaughan St retail site will be developed within a year, with its sale to a major developer expected to be announced early next week.
Greater Shepparton City Council yesterday confirmed a buyer had been found for the existing retail sites on the northern side of Vaughan St and the vacant 16
A formal announcement was originally set for late yesterday, but Lascorp Development Group is expected to be confirmed as the purchaser next week, ensuring that the original vision for the precinct will become a reality.
Shepparton Retail Investments had proposed a $22
The plan came unstuck when the company was placed into liquidation late last year.
In March, the liquidators put the properties on the market as two distinct lots, the occupied retail sites and the development site, but the hope was one developer would take on both and work with council, which is committed to the urban renewal of the precinct.
Lascorp, founded in 1972 by famed Melbourne retailer Myer Lansky, is one of the biggest developers of supermarket and supermarket-based shopping centres in Australia. The company has undertaken a similar town-centre project in Seville and has successfully completed major shopping complexes across Australia.
''The Vaughan St site provides a vital piece to the puzzle for the Shepparton central business district retail plan, and future development of the site will contribute to the health of the central business district overall,'' Mayor Michael Polan said.
''The retail redevelopment, and council's planned contemporary urban streetscape, will greatly improve the area's attractiveness to visitors and residents.''
The streetscaping includes changes to parking, improvements in pedestrian access, provision of public spaces, bike racks and improved lighting.
''The redevelopment of the retail area and the streetscaping are the first step in providing an important link between Shepparton's travel hubs and the CBD, linking the railway precinct to the mall,'' Cr Polan said.
Thankyou for your comment.Your comment will appear once it has been approved by MMG staff.
VIDEO: Shepparton police foot pursuit
Shepparton police pursued two youths on foot near Waters Rd this afternoon.
Lions win top of the table clash
The Mulwala Lions took a huge step forward in the race for the Murray League title with a hard fought, low scoring, 15 point win, against the fancied Barooga outfit, in near perfect conditions at Lonsdale Reserve on Saturday.
New name new owner
Chelsea Campbell is excited with her new business venture, after purchasing Carol Taylor's hairdressing salon in Hogan St.
Running out of superlatives
THE Community Living & Respite Services Johnno's Run team raised almost $21,000 on Sunday.
They can't bear to see upset kids
ROCHESTER'S Leo Club former president Monique Keech and president Tekyra Shead have presented the Rochester and Elmore District Health Service and Rochester Ambulance service with plush teddies as part of their operation teddy bear program.
Fruit shop squashed
City decision making process puts local out of business
Swans respond to dressing down
Avenel senior football coach made his feelings clear to players ahead of game against Violet Town.
$1.6m Amaroo development
Berrigan Shire Council have approved a development application for six more independent living units to add to Berrigan's Amaroo Self Care Unit block.
Clarke's familiar faces surprises paceway fans
HEATHCOTE Park Raceway was back in action on Sunday with a surprise for those expecting owner Russell Clarke to be enjoying his retirement.
Beautiful birds at auction
Dozens of birds of all shapes and sizes flew the coop as Cobram hosted its inaugural poultry auction last Sunday.
Deni's new Lion leader
Neil Buckley has been inducted as president of the Deniliquin Lions for the next 12 months.
Health benefits from pears promoted
A new research project conducted by CSIRO is seeking to better understand the health properties of pears to help improve and develop market and marketing opportunities.
Junior football derby
The Benalla Giants came out winners in both the under-14s and under-16s against the Benalla Bulldogs on the weekend.
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- pbpbpbpb1 voted for heartbreaker (side 1) on the story "Dating My Son's Old High School Classmate"
- pbpbpbpb1 voted for abby2 (side 2) on the story "Roommate Window Argument"


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Jan 20 2015
NYIT Selected to Participate in Epicenter's Pathways to Innovation Program
NYIT Selected to Participate in Epicenter's Pathways to Innovation Program
NYIT Ranks Among 2015 U.S. News Best Online Programs
Architecture and Medical Students Launch Global Competition for Healthy Designs
BBC to Feature Home2(O) Project in News Segment
NYIT Wins Grant to Develop STEM Programs
Graduate Tuesdays
SAG Foundation's Screening of "Olive Kitteridge" + Q&A with Richard Jenkins
SAG Foundation's Screening of "Playing House" + Q&A with Jessica St. Clair and Lennon Parham
Graduate Tuesdays
SAG Foundation's Screening of "Key & Peele" Episode + Q&A with Keegan-Michael Key
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List all words ending with optatives
Only the word optatives was found, nothing longer.
Some random words: ceanothus beige diode jiao bloat gieing soever
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From Publishers Weekly
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.
From Booklist
Copyright © American Library Association. All rights reserved
Product Details
Would you like to update product info or give feedback on images?
Could have been fascinating. It is poorly written, desperately needed a good editor. It is infantile, and never decided who the audience was. A waste of time. Don't bother.Published 1 month ago by Sergio
Incredible journalism/research. Second best book I have read this year
For those interested in historical novels this should not be missed
Although I am Jewish and have read so much about a World War 2 I never knew about people going to Shanghai. I learned about a whole new "ghetto" which was always under a threat. Read morePublished 4 months ago by Jan Tarlow SNyder
interesting reading. I was not aware of the Shanghai conditions. Such a courageous family.
the book ended rather suddenly. Read more
I've read about Jews emigrating to Shanghai before, but Kaplan's book gives a lot more depth and follow up after the Holocaust years. Read morePublished 7 months ago by CK


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Relevant offers
From Aaron Gilmore's "dickhead" quote to Maurice Williamson's "big gay rainbow" Massey University's quote of the year shortlist is a catalogue of some of the most memorable one-liners of 2013.
Others to feature on the list were Lorde, Eleanor Catton, Kim Dotcom and John Key.
Some the best quotes were comments on New Zealand society, including author James McNeish's: "In New Zealand nobody takes you seriously unless you make them yawn."
Massey University speech-writing specialist Dr Heather Kavan said singer-songwriter Lorde's "I'm not a spreadsheet with hair" was powerful because it helped dispel the myth that it's okay to judge people by their monetary value, rather than by their unique abilities.
"I think this is a myth many people would love to see dispelled," she said.
Politicians featured prominently again for the award now in its third year, with seven different lines from Cabinet minister Maurice Williamson's speech on gay marriage nominated.
"They were all great quotes and it was difficult to choose between them," Kavan said.
"In the end we chose the gay rainbow quote because the speech became known as the gay rainbow speech."
Quotes from politicians tend to dominate the list because they get a lot of publicity, she said.
"With some of the quotes, especially the ones in which Kim Dotcom and Winston Peters question the prime minister, there is also an element of pleasure at seeing someone in a superior position questioned."
Kavan and her judging panel narrowed down several dozen entries nominated throughout the year by Massey students and the general public to a top 10.
Context and memorability were important judging criteria, Kavan said.
"Memorability is paramount," she said.
"The gay rainbow line with its colourful imagery is a good example of this. However, many of the quotes appealed for different reasons.
"The GCSB one stood out because it was funny and most people can relate to having a frustrating experience with a government department.
"We were also keen to get quotes that were relatively spontaneous, such as Winston Peters' 'What didn't he know and when didn't he know it?'.
"Another criterion was context.
"We chose 'He's an extraordinarily lucky cat' because Moomoo's story [the cat survived being shot in the head with a crossbow bolt] made international headlines and even the word 'extraordinarily' seemed like an understatement."
To vote for the 2013 Quote of the Year, visit Massey University's Facebook page.
Voting closes at 5pm on Thursday, December 19, with the winner announced on December 20.
* "If there was a dickhead that night, it was me" - then-MP Aaron Gilmore reflecting on how he got intoxicated and called a waiter a "Dickhead" at the Heritage Hotel in Hanmer Springs.
* "Why are you going red, prime minister?" - Internet entrepreneur Kim Dotcom at the parliamentary inquiry into the GCSB spying on New Zealand residents.
"I'm not, why are you sweating?" - John Key's reply.
* "The GCSB, the only government department that will actually listen to you" - Origin unknown but repeated on social media.
* "Male writers tend to get asked what they think and women what they feel" - Man Booker prize winning novelist, New Zealand's Eleanor Catton.
* "I'm not a spreadsheet with hair" - Auckland singer/songwriter Lorde.
* "What didn't he know and when didn't he know it?" - NZ First leader Winston Peters querying Key's knowledge of the Parliamentary Service's actions.
* "In New Zealand nobody takes you seriously unless you can make them yawn" - author James McNeish at the Auckland Writers and Readers Festival.
* "That little ball of fluff you own is a natural born killer" - Economist Gareth Morgan's Cats to Go campaign website.
* "He's an extraordinarily lucky cat" - Massey University veterinary surgeon Dr Jonathan Bray after removing a crossbow bolt from the head of Wainuiomata cat Moomoo.
* "One of the messages that I had was that this bill was the cause of our drought. Well, in the Pakuranga electorate this morning it was pouring with rain. We had the most enormous big gay rainbow across my electorate" - Cabinet minister Maurice Williamson in his speech to Parliament supporting the gay marriage law.
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'Unacceptable' wait for ambulance after player breaks leg at football match


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Amir Johnson does not have a second career in baseball waiting
May 14, 2013, 3:30 PM EDT
Is this worse than John Wall's epic first pitch? (To be fair, he got better the next time.)
I think not this so because as bad as Amir Johnson's first pitch was — and you can see in the video above, it was terrible — he redeems himself by asking for a do-over, then launching the second pitch into the second deck.
Still, there will be no late-season call up Johnson. Baseball is not his sport.
Mario Hezonja had a few Summer League highlights (VIDEO)
Jul 28, 2015, 8:30 AM EDT
The man made some plays.
Mason Plumlee rapping? Yes, Mason Plumlee rapping. (VIDEO)
Jul 28, 2015, 8:00 AM EDT
Mason Plumlee with a money gun shooting $100s.
James Ennis allows Heat to push back decision on him until opening night
Jul 28, 2015, 12:40 AM EDT
Ennis will get the chance to prove his case in training camp.
Gregg Popovich missed games last November due to heart procedure
Jul 27, 2015, 11:00 PM EDT
Larry Brown said the condition had Popovich thinking about retirement.
Lance Stephenson dancing with Teenage Mutant Ninja Turtles? We got that. (VIDEO)
Jul 27, 2015, 10:01 PM EDT
Well, you don't see that every day.
Larry Bird: Michael Jordan would "kill me" right now in one-on-one
Jul 27, 2015, 9:00 PM EDT
Wasn't this obvious already?
Lakers' coach Byron Scott says Kobe Bryant will "probably" play some power forward
Jul 27, 2015, 7:59 PM EDT
It could work — in very limited circumstances.
Larry Bird says Stephen Curry, himself in mix for best deep shooter ever
Jul 27, 2015, 6:59 PM EDT
Bird also says Jordan would destroy him one-on-one right now.
Report: Heat will pick up contract of Tyler Johnson, as expected
Jul 27, 2015, 6:32 PM EDT
James Ennis seems on the bubble with Miami.
Gilbert Arenas goes full hibachi at county fair hoops game, gets all the stuff animals
Jul 27, 2015, 5:30 PM EDT
I so hope this isn't staged.
Phil Jackson says Knicks wanted Goran Dragic at trade deadline. Because he's such a triangle fit?
Jul 27, 2015, 5:01 PM EDT
Dragic would not have fit the triangle, but he's talented.
Roy Hibbert pleased to have a coach who played in NBA (psst: it's Byron Scott)
Jul 27, 2015, 4:05 PM EDT
Center goes from Frank Vogel to Byron Scott and is happy about it
Will Bucks arena deal pass Wisconsin Assembly?
Jul 27, 2015, 3:08 PM EDT
Key Democrat implies it's not a certainty
Report: Kings trying to hire Bobby Jackson, too
Jul 27, 2015, 2:19 PM EDT
Vlade Divac is trying to put the band back together
Report: Heat will pay Zoran Dragic's full salary, Celtics will waive him
Jul 27, 2015, 1:38 PM EDT
Celtics and Warriors finalize David Lee trade
Report: Cavaliers sign Matthew Dellavedova
Jul 27, 2015, 12:34 PM EDT
Did he accept the qualifying offer?
Pacers sign Shayne Whittington, guarantee his salary for this season
Jul 27, 2015, 12:11 PM EDT
Indiana apparently liked what is saw from undrafted free agent last season
Heat trade Zoran Dragic, second-rounder to Celtics
Jul 27, 2015, 11:25 AM EDT
Protected second-round pick going back to Celtics
Report: LeBron James OKs Mike Miller trade
Jul 27, 2015, 10:12 AM EDT
Miller reportedly wanted to leave Cavaliers for a team that would play him more
Reports: Knicks signing Darion Atkins, Wesley Saunders
Jul 27, 2015, 9:32 AM EDT
Both players to receive partially guaranteed contracts
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- Report: Cavaliers sign Matthew Dellavedova 8
- Heat trade Zoran Dragic, second-rounder to Celtics 11
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- Blake Griffin, Stephen Curry among latest big names headed to Team USA mini-camp 8
- Kyrie Irving off crutches, cleared by doctors to start working out 8
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text: Mashup: digiPoem Share via FacebookShare via TwitterShare via LinkedinShare via Google+Share via RedditShare via Mail digiPoem generates simple visual embellishment of poetry and other text sources using image tagging on Flickr. Track this Mashup Submit a mashup Summary Comments Followers Comments (0) Comment * Leave this field blank Post Comment Followers (2) Track this Mashup Username bgood iancorbin Specs Related APIs Flickr, Lyricsfly Tags Photos, Writing, Lyrics, Education, Visualizations, Music URL http://www.dudeyjon.com/digipoem/ Followers (2) /View all Track this Mashup Mashups using the same API (658) /View all Flickr Watch Watch new photos being uploaded to Flickr in real time. Uses Ajax. Montreal Transit Planner Montreal public transit planner helps you find your way around Montreal. Specify your origin, destination, and options related to your trip. Stop photos are dynamically retrieved from Flickr. dewspot The dewspot.com allows you to mix with video, map, photo, weather forecasts and twitter messages. It has impressive interface. Developers periodicaly add new features. Wishes are welcome. Add Mashup Related Articles /View all Google Earth API Set for Execution Google Earth API Set for Execution Google has announced its intent to deprecate the Google Earth API. In its six years, the Google Earth API has driven many rich 3D mapping applications. News Eric Carter Mapping, Visualizations 12-12-2014 Google Earth API Set for Execution 50,000+ Radio Stations in One API 50,000+ Radio Stations in One API Shoutcast maintains a radio directory of 50,000+ radio stations from all around the world. The company, owned by AOL, released its first Shoutcast API a few years ago, but has since released versio... News Diego Montalvo Music 01-26-2012 50,000+ Radio Stations in One API Mobile and Web Image Recognition with Moodstocks API Mobile and Web Image Recognition with Moodstocks API The Moodstocks API provides image recognition services that developers can integrate into their mobile and web applications. The image recognition API allows developers to add reference images a... News Kin Lane Mobile, Photos, Images 08-03-2011 Mobile and Web Image Recognition with Moodstocks API RELATED APIs Promoted /View all API Name Description Category Date Key Captcha The uniqueness of Key Captcha consists in website authorization solving simple puzzles. An example would be assembling a puzzle piece into an apple image that is missing the piece. Key Captcha could... Captcha 07.27.2015 UC Berkeley CoolClimate With the CoolClimate API, an initiative created by the University of California, Berkeley developers can create projects that calculate carbon footprints, measurement that assists with the individual... Climate 07.27.2015 Burning Soul Moon Moon API is part of an independent project by Burning Soul, a computer and technology organization. This API allows to obtain data from the moon such as current age of the moon in days, illumination... Science 07.20.2015 Unofficial Instructables Unofficial Instructables API available on Mashape. Instructables in a DIY platform that allows to publish online guides. This resource does not guarantee support by Instructables, however it aims to... Education 07.20.2015 Cantus The Cantus API provides developers with tools to use for Cantus database-access projects. It allows for searching and reading through the database, and creating and editing resources. The CANTUS... Music 07.12.2015


text:
Bringing the Hallmark brand into B2B e-commerce
95% of the orders at Hallmark Business Connections are processed online, CEO Tressa Angell says.
Bringing the Hallmark brand into B2B e-commerce
95% of the orders at Hallmark Business Connections are processed online, CEO Tressa Angell says.
The web grows 20% for Yoox in the front half of 2015
In its last earnings report before its expected merger with Net-A-Porter, Yoox reports good results for web sales overall and a stellar performance from ...
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But the e-commerce site was back up by mid-morning.
Posted 11/14/2013Thad RueterPost a comment
Related Content:Holiday Readiness
A scheduled maintenance update causes several eBay sites worldwide to go dark.
Posted 08/26/2013Amy DustoPost a comment
The outage, which began about 1:45 p.m. Central, lasted 46 minutes, Pingdom says.
Posted 08/19/2013Thad RueterPost a comment
The site outage lasted less than 10 minutes this morning.
Posted 05/10/2013Thad RueterPost a comment
A Starbucks coupon offer blacked out some Groupon services Friday.
Posted 03/22/2013Allison EnrightPost a comment
The e-retailer's site suffers an outage for nearly an hour.
Posted 01/31/2013Thad RueterPost a comment
Amazon announces plans to prevent blocked video streaming.
Posted 12/31/2012Paul DemeryPost a comment
The online grocer fails to renew its web site address.
Posted 12/28/2012Zak StamborPost a comment
Related Content:Freshdirect
Retailers on the platform say they've experienced repeated downtimes.
Posted 12/17/2012Paul Demery1 comments
The site problem arrives less than two weeks before Christmas.
Posted 12/13/2012Thad RueterPost a comment


text:
July 21
Nigeria: Local Meter Manufacturers Want Intervention Fund
Daily Trust
Executive Secretary, Electricity Meters Manufacturers Association of Nigeria (EMMAN),Mr.Muideen Adebayo has urged the Federal Fovernment to consider 2 percent special intervention... Read more »
Nigeria: An Endless Wait for Policy Direction
This Day
Crusoe Osagie discusses the impediments of the endless wait for policy direction for manufacturers and other operators in the Nigerian economy. Read more »
Nigeria: Unilever Takes Omo to Abuja, Neighborhoods
This Day
Newly improved Omo fast action, the multi-active hand-washing detergent powder and a product of Unilever has toured major cities in the Federal Capital Territory to the excitement... Read more »
July 20
Zimbabwe: Mnangagwa Tours Giant Belarus Firm
The Herald
Vice President Emmerson Mnangagwa yesterday toured the Belaz Mining Manufacture Company here and said Zimbabwe will benefit immensely from cooperating with the giant firm, one of... Read more »
Ethiopia: Unexpected, Yet Moving Visit
Addis Fortune
Despite the packed agenda, the recently concluded Third International Financing for Development (FFD3) conference brought international power shakers very close to ordinary people.... Read more »
Nigeria: Samsung Introduces New TV Tech in Nigeria
Daily Trust
Samsung Electronics West Africa has introduced the world's first curved Stylish Ultra High Definition (SUHD) television to Nigerian consumers to boost viewing experience. Read more »
Nigeria: Coming Boom in Nigeria's Automotive Industry
Since the National Automotive Industry Plan (NAIDP) was announced by the Federal Government in October 2013, the Nigerian automotive industry has witnessed serious interest from... Read more »
July 19
Nigeria: Okoli - Why Nigeria's Pharmaceutical Industry Can't Compete Globallly
This Day
Chief Executive Officer of Emzor Pharmaceuticals recently held a round table session with select journalists where she highlighted some of the challenges facing the manufacturing... Read more »
July 18
Ethiopia: Ethiopia Launches a 10-Year Pharmaceutical Action Plan
Set to generate USD 80 million hard currency Read more »
July 17
Kenya: Embu Brewery Demolished
The Star
Embu county commissioner Amos Gathecha on Thursday led residents in demolishing a three-storied building used to brew illicit drink Machore. Read more »
Nigeria: Honda Opens Assembly Plant in Nigeria
Honda Motor Co., Ltd. has announced that it began local production of the Accord sedanin Nigeria. The car plant is expected to be the first assembling attempt of thefirm in Africa. Read more »
Namibia: SABMiller Goes Live At Welwitchia
Namibia Economist
The town of Okahandja was the scene of celebration this week when the world's second biggest brewer, SABMiller, officially opened its Welwitchia Brewery in the industrial area of... Read more »
Uganda: Cabinet Approves National Leather Policy
Cabinet has approved the National Leather and Leather Products Policy, 2015, as part of efforts to create a competitive leather industry. Read more »
Namibia: Sabmiller Could Expand Okahandja Plant to 400 000 Hectolitres
SABMILLER Namibia's newly built plant at Okahandja has the potential to expand its production capacity to an initial 300 000 hectolitres and a final capacity of 400 000 hectoliters... Read more »
July 16
Ethiopia: Nation Launches Pharmaceuticals Manufacturing Development Strategy, Action Plan
Ethiopian Herald
As part of the flagship programme of the Growth and Transformation Plan, Ethiopia has launched a decade-long awaited National Strategy, Plan of Action for Pharmaceuticals... Read more »
Liberia: Arcelormittal Gets New CEO [press release]
New Dawn
ArcelorMittal, the world's leading steel and mining company has announced Mr. Simon Wandke as its new Executive Vice President and is expected to be Chief Executive Officer. Read more »
Zimbabwe: Zim Urged to Go for Contract Manufacturing
The Herald
Zimbabwe could replicate the success of contract farming by engaging in contract manufacturing in the food sector, Reserve Bank of Zimbabwe (RBZ) economic research director Mr... Read more »
Kenya: Kenyan Manufacturers Set to Reap From GES
Capital FM
Manufacturers in the country should take advantage of the upcoming Global Entrepreneurship Summit which will be chaired by US President Barack Obama alongside President Uhuru... Read more »
Nigeria: Chicason Group Begins Talks With Anambra Government Over Raw Materials
Independent (Lagos)
Nnewi, Anambra state based Chicason Group Conglomerate, manufacturers of motor engine oil, plastic and household consumables, has opened discussion with the Anambra State... Read more »
Uganda: Manufactures Cry Foul Over High Power Tariffs
Manufacturers need to be very cautious if they are to survive in a difficult economic environment, the chairperson Uganda Manufacturers Association (UMA) has warned. Read more »
July 15
Botswana: Capacity Building Intiatives in Place
Botswana Daily News
There have been initiatives to build capacity in the leather industry in Botswana, including the Local Enterprise Authority (LEA) training 46 clients in their leather incubator... Read more »
Kenya: Nakuru Plant to Assemble Cheap Tractors From Korea
The Star
Farmers will get access to cheap locally assembled tractors and other farm machinery from South Korea starting in October. Read more »
July 14
Nigeria: Tata Invests U.S.$8 Million in Nigeria's Auto Industry
This Day
Tata Motors Limited has invested over $8 million US dollars as part of its preparations to roll out its first batch of Nigerian assembled cars and the subsequent exportation of... Read more »
Rwanda: Cement Prices Will Decline Gradually - Cimerwa Chief
New Times
Juvenal Rutaganda is the operations manager and acting chief executive officer of Cimerwa cement factory. The firm unveiled a new hi-tech plant last week, which is expected to... Read more »
Nigeria: KIA Siblings Sweep Autopacific Awards
Four models from Kia Motors America (KMA) were recognized as segment winners of the 2015 AutoPacific Vehicle Satisfaction Awards (VSA), including the Quoris luxury sedan, which... Read more »
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Boston News
Local news for Boston, MA continually updated from thousands of sources on the web.
The Rock leaves Boston with a giant thank-you note
16 hrs ago | Boston.com | Comment?
Boston's best restaurant patios
16 hrs ago | Boston.com | Comment?
Welcome to Boston. Hope you're not in a hurry.
18 hrs ago | Boston.com | Comment?
Lansdowne Street bars forced to deal with racist Sox fans from NH, an ...
20 hrs ago | Universal Hub | Comment?
Bill on Beacon Hill would fight gentrification in neighborhoods
20 hrs ago | Worcester Telegram ... | Comment?
Loosing Innocent Lives In An Airstrike: Do the Pros Out...
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19 Hollywood Stars With Terrible Personal Hygiene Habits
How Should the US Government Respond to ISIS?
East Boston lofts have an industrial flair
22 hrs ago | Boston.com | Comment?
Read Boston Storymobile Visits The John F. Kennedy Family Service Center
Boston Creates Holds A 2nd Community Meeting
Boston African American National Historic Site Offers Summer Programming
Synergy nets tidy gain with sale of 2 Oliver St. in Boston
Yesterday | Business Journal | Comment?
Scholars drawn to conflict zones stoke college safety debate
Yesterday | Greenwich Citizen | Comment?
10 of the best burgers in Boston
Yesterday | Boston.com | Comment?
Two arrested in Boston carjacking
Norfolk Looks For Home For Abused Dog
Monday | CBS Local | Comment?
The Boston Olympics are dead; the year 2024 is alive and well
John Williams cancels Boston appearances in August
Updated: Wed Jul 29, 2015 07:09 am
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text:
House of Grand'uer manufactures one of a kind heirloom quality wedding keepsakes and decor. Our team of bespoke designers will craft the items of your (more)
Bridal Registry for your upcoming wedding. Items can be selected, purchased, and delivered all via the internet. Items can even be gift wrapped! Please (more)
Wedding and party favors for any occasion. Custom orders, Gourmet apples, Chocolate dipped oreos, grahams, pretzels, Cookie bouquets, Gift baskets centerpieces, (more)
Evening clothing wholesaler from China the lowest price. Easy shopping, quick shipping, our online store will save you time and money. Here you can get (more)
S.N.O.B.B. _Something New Something Old Something Borrowed Something Blue is your premier provider of natural handmade skin care products for your entire (more)
The One Stop Wedding Shop for all your wedding needs. Specializing in Custom Handmade Rose Wedding Bridal Bouquets and Wedding Floral Arrangements custom (more)
House of Grand'uer manufactures one of a kind heirloom quality wedding keepsakes and decor. Our team of bespoke designers will craft the items of your (more)
Ben's Bridal offers accessories and supplies for weddings and special occasions. (more)
From classic wedding gowns to modern party dresses for Weddings you need through 3000+styles items we sorted for you. Your fantastic occasions wear (more)
Start your Utah wedding planning by browsing for local wedding vendors. From photographers in Salt Lake City to officiants and disk jockeys in Provo we have the wedding service providers you need.


text:
Beautiful aniline leather love seat and sofa - originally purchased at Macy's for 10K+. Asking $650 for the set OBO - would be willing to separate the set if needed. Both are 39 inches high, 44 inches deep - love seat is 61 inches long, sofa is 88 inches long. Both do have some imperfections/scratches (pictured) - could easily be restored and used or re-sold for much more.
Jul 28 - La Grange
$1,100...This is a very gently used set complete with couch, loveseat, chaise, coffee table and 2 end tables. call/text
Jul 28 - Richton Park
4 piece Microfiber Sectional Sofa purchased from Carson Pirie Scott...Great condition. Very comfortable, versatile, easy to clean. Pieces can be repositioned easily, as you like. Great deal. $750 OBO
Jul 25 - Chicago
Overall in decent shape. $10 buys it. Need to sell. Please call if interested!!!
Jul 19 - Justice
Lazy boy love seat, both seats recline, excellent condition. Asking $350 or best offer.
Jul 17 - Valparaiso
Chateau d'Ax Italia Relax and Motion Leather Sectional. Pearl color. 3 pieces. 3 of the seats recline fully. Beautiful soft leather, very, very comfortable. Well taken care of. Smoke free and pet free home. 2 years new.
Jul 17 - Hoffman Estates
This is a CLEAN 3piece set. Couch, love seat, and oversized chair. The leather is super soft and the cushions are yielding, yet firm. You can get a good nites sleep or power nap on these honeys. The set is in great shape and has low usage. If you're looking for something sleek and classy with a contemporary vibe, check them out. Parting with them due to a clash of style/decor with my new home ...
Jul 17 - Bristol
Exceptional quality and distinctive design, our Mandalay 2 piece sectional features a gently curve back with contrast stitching and a row of tufting along the back and seat. Expertly tailored in a peak white leather with venge legs. Or custom order from a variety of leathers and microfibers. Prices may vary depending on the leather grade. Please allow 16 weeks for custom orders. The swatches ...
Jul 13 - Chicago
Like new Lazy Boy love seat. Asking $350
Jul 10 - Valparaiso
With a comfortable contemporary design, the "Zella-Charcoal" upholstery collection takes the comfort of plush cushions and soft upholstery fabric and creates a sleek style with the shaped arms subtle gray-toned upholstery that enhances the décor of any home. Price:$799 2Pc. Sectional 71" x 108" Left arm facing chaise 108" x 71" Right arm facing chaise
Jul 9 - Mchenry
Sofa Bed Revolution 3 in 1. Sitting, sleeping, storage. Coil springs & no crossbars give these sofa beds the comfort of a real mattress. Available Queen / Full sizes. Fits through narrow doorways & stairwells. Dimensions: Sofa, 79"x37"x33"; Bed 79"L x 55"W
Jul 9 - Mchenry
With a stylish contemporary design and numerous modular pieces to create unlimited set-up options to fit within any living area.Soft upholstery fabric surrounding plush supportive cushions to give you comfort as well eye-catching beauty. Price:From $769 to $1399 Left or right facing chaise available Left or right facing loveseat available CALL STORE FOR DETAILS
Jul 9 - Mchenry
Beautifully designed with dramatic rolled arms, jumbo window pane stitched detailing and classic nail head trim accents, the "Larkinhurst-Earth" upholstery collection is covered in a soft leather look fabric that adds the ultimate in comfort while holding onto the classic traditional design that is sure to enhance any living room decor. Price:$1048 Sofa and Loveseat ( NEW ) $559 Sofa - 89"L x ...
Jul 5 - Mchenry
Best Home Furnishings sofas and loveseats add instant comfort to any room. Our stationary sofas, reclining sofas, and sleeper sofas come in a wide assortment of styles, finishes, fabrics and leathers - from traditional to contemporary. The Annabel Series by Best Home Furnishings is truly a custom seating program. The option to create the sofa or loveseat you want from the options below, in ...
Jul 5 - Mchenry
The Samuel 100% bonded leather sectional offers style and comfort.Features clean lines and attached cushions.Hardwood frame,webbed back,sinuous spring base with pocket coil cushions, baseball stitching. 3Pc sectional 91" x 91" 4Pc sectional 91" x 114" (L arm loveseat + corner + armless chair + R arm loveseat) Left or right setup ***** Price:$999 3Pc L Arm Loveseat + corner + R Arm Loveseat ...
Jul 5 - Mchenry
Fantasy Sofa Bed In Aristo Burgundy fabric will give your living room the comfort you have been looking for. This Versatile, functional and convertible sofa can be transformed into a big* bed in a few seconds.No crossbars give these sofa beds the comfort of a real mattress.*Check other sofas for hard surface on the middle 78"Lx37"Dx35"H (78"x61") Price:$699 Sofa bed Aristo Burgundy fabric ...
Jul 5 - Mchenry
The reclining Cranley Collection utilizes release mechanism that with a gentle pull sends you straight into your ultimate comfort zone. Tufted bonded leather covers the overstuffed arms, seats and backs furthering the comfort for you, your family and friends. Sofa 83" x 39" x 38"H Loveseat 60" x 39" x 38"H Recliner 40" x 39" x 38" Price:$978 Reclining Sofa and Reclining Loveseat AVAILABLE IN ...
Jul 5 - Mchenry
Thomas O'Brien by Hickory Chair | SOHO Studio Sofa 96" inch | ONLY $2350 Cash (Just reduced by an extra $800) - Originally Over $7000 list price - SAVE $5,000 Moving sale | Our move is your win. Save over $5000 today A unique SOHO style sofa in Excellent condition. If you're on the cutting edge of design this is a modern yet classic heirloom piece of furniture that has just the right ...
Jul 3 - Chicago
Up for sale is a reclining couch and loveseat. Both are in great condition. I am the original owner and I have taken great care of them. Material is a brown microfiber, no stains, no rips, and mechanics in couch for reclining work perfect. 2 end seats on coach recline. $600 or best offer
Jun 22 - Frankfort
Custom Italian Chaise Lounge / Dongia Fabric / One of a kind piece / like new.
Jun 22 - Lake Zurich
Love Seat Custom Italian Made with Donghia Fabric upholstery / Plush warm brown color with espresso legs / frame constructed ok kiln dried hardwood / 78 inches wide – 36 inches high / 17 inches seat height / Like New Condition.
Jun 22 - Lake Zurich
100 percent leather sofa Broadway brown color brand new never been used I just had it delivered to my house today on June 19th the reason I'm selling it is because it can't fit into my living room I'm trying to sell it as soon as possible its $400 The sofa is worth $800. It's 88 in length and 37 in width.I live on the south side of Chicago between cottage grove and Stoney island contact me at ...
Jun 19 - Chicago
Sofa & loveseat bonded leather, American made by Simmons Available in two colors black and brown Special Price: $799 Immediate delivery. For inquiries call or visit us at 4805 S Ashland Ave Chicago, IL 60609 Thank you!
Jun 19 - Chicago
Beautiful living room set. American made, flip T cushions. Sofa and loveseat both: $799 Sofa alone: $799 Loveseat alone: $779 You can have the loveseat for FREE if you buy it with the sofa for $799. For inquiries call us from 11:00 AM to 6:00 PM or send us an email. We are located at: 4805 S Ashland Ave Chicago, IL 60609 Pick up or delivery. Thanks for reading!
Jun 19 - Chicago


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Walnut Creek HotelsThe lush and fertile grasslands and rolling hills of Walnut Creek have set it apart when it comes to experiencing the great outdoors, with numerous hiking trails, camping, and biking adventures to be found amount the emerald landscape. The city is also the main business hub in the area, so you'll find some great shopping here, and there's also a vibrant dining scene bursting with flavors, and all kinds of tempting cuisine, just waiting to be discovered by food fans.Things to seeShopping is very good in Walnut Creek in general, but the experience offered by Broadway Plaza is particularly refined. Shoppers mill around an elegant, cascading central fountain surrounded by preened bushes and plants, and the modern, but classic design of the center makes for a much more relaxing shopping experience in general, where you can take your time and enjoy the sights of the center itself. To compliment a day of relaxing shopping, spending a lazy afternoon wandering through the vivid colors of the Gardens at Heather Farm is highly recommended. The Gardens are a popular wedding venue thanks to the pristine beauty of the surroundings, but also offer education on gardening in general, so is especially interesting to those with green fingers. If you're on a family trip, then Lindsay Wildlife Museum is great for everyone, and kids can get involved with workshops to learn more about animals.Hotels in Walnut CreekThere's a good selection of Walnut Creek hotels, so there's plenty of affordable choices for families looking for outdoors breaks as well as business travelers. The higher end offerings come equipped with luxurious spas, crystal-clear pools, and bustling. Even some of the discount hotels in the area offer access to sparkling outdoor pools, although be aware that these are obviously seasonal. Most of hotels are also located in or very close to the major attractions of the city, so getting to attractions is easy. Where to stayStaying in the area around Treat Blvd is a popular choice for tourists of all stripes, thanks to the fact that most of the city's main attractions are very close by, such as the Heather Farm Gardens, with the city center a short distance away. Business travelers will probably prefer accommodation along North Main Street, especially the southern end which is closer to the city center and amenities. Those looking for outdoor adventures, or even a little romantic seclusion, can always opt for digs slightly outside of town, where there's easy access to the countryside, and also luxurious spa hotels. How to get to Walnut CreekIf you're flying in, then heading to Oakland International airport, if coming from overseas, is the closest destination. Alternatively, if you're flying domestically, there is a small regional airport, Bucchanan Field, in neighboring Concord that will be the perfect gateway to the city. If arriving in Oakland, hiring a car can be the best option, but there's also a shuttle train service that runs from Oakland and San Francisco into Walnut Creek. Once in the city, walking will normally be the best way to get around, as the downtown area is quite compact and attractions are generally close together.
Hotels in Walnut Creek
See Walnut Creek hotels on a map
Best Walnut Creek hotels
Trending now in Walnut Creek
Hotels in Walnut Creek
- Most booked
Embassy Suites Walnut Creek
Excellent 4.3 / 5 ( 610 reviews )
102 people looked at this hotel in the last hour
Most recent review
"Quick overnight getaway for my husband and me. Always enjoy Embassy Suites and their amenities. Particularly enjoy happy hour and cooked to order breakfast."
A Traveller, Jul 2015, US
Walnut Creek Marriott
Excellent 4.1 / 5 ( 318 reviews )
62 people looked at this hotel in the last hour
Most recent review
"The hotel was very nice. Bed was very comfortable. Nice bar area on the first floor. Valet parking, and they have a shuttle that will take you downtown. The hotel is easy to get to from the freeway and in a convenient location. Would stay here again. My only complaint is the pool is significantly..."
A Traveller, Jul 2015, US
Holiday Inn Express Walnut Creek
Excellent 4.2 / 5 ( 671 reviews )
55 people looked at this hotel in the last hour
Most recent review
"Stayed here several times. Love the free breakfast and free parking. Staff very friendly, hotel very clean and quiet. No complaints here!"
A Traveller, Jul 2015, US
Motel 6 Walnut Creek
Good 3.5 / 5 ( 129 reviews )
43 people looked at this hotel in the last hour
Most recent review
"It's a great place to stay for an overnighter. No real amenities but if you just need a place to sleep, it's perfect. The walls are thin though. There were some partiers next to me that interrupted my sleep. But that's more of a luck of the draw."
A Traveller, Jul 2015, US
Renaissance Clubsport Walnut Creek Hotel
Excellent 4.6 / 5 ( 179 reviews )
38 people looked at this hotel in the last hour
Most recent review
"It was wonderful to finally get into a clean room, spotless shower and the most luxurious bed. Everyone remembered our names and was helpful smiling and my 14 year old daughter loved it when valet called her miss. Haha the little things count. They are right on point."
A Traveller, Jul 2015, US
Diablo Mountain Inn
Good 3.3 / 5 ( 70 reviews )
17 people looked at this hotel in the last hour
Most recent review
"Staff friendly and helpful would make direct reservations next time"
A Traveller, Feb 2014, US
Hotels within 5 miles of Walnut Creek
Lafayette Park Hotel & Spa
Excellent 4.6 / 5 ( 282 reviews )
68 people looked at this hotel in the last hour
Most recent review
"We needed a night away, and what a great place to spend the night! When we checked in, the front desk employees were very friendly! My only complaint; we went to use the hot tub, the bubbles were not working. I called down to have someone check it out. We waited about 15 minutes and no one came. ..."
A Traveller, Jul 2015, US
Courtyard by Marriott Pleasant Hill
Excellent 4.3 / 5 ( 240 reviews )
49 people looked at this hotel in the last hour
Most recent review
"I really enjoyed my stay at the Courtyard. They were affordable and clean and the staff was really nice. I would recommend staying here if you want to be within walking distance of all the downtown stores in Pleasant Hill. The only slight problem about the hotel's location was being so close ..."
A Traveller, Jun 2015, US
Extended Stay America Pleasant Hill - Buskirk Avenue
Fair 2.7 / 5 ( 127 reviews )
31 people looked at this hotel in the last hour
Most recent review
"The desk clerks were all very friendly.The room was very clean upon entry. Quiet area. We were very pleased and comfortable. We will be back to stay when needing to reside there again for a few days."
A Traveller, Jun 2015, US
HYATT house Pleasant Hill
Excellent 4.6 / 5 ( 279 reviews )
26 people looked at this hotel in the last hour
Most recent review
"My stay was fantastic and the front desk is quite helpful"
A Traveller, Jul 2015, US