text:
Nick Swisher: Best Fit Is With Texas Rangers
For the last eight seasons, Nick Swisher has homered at least 20 times in all of them. However, as the calendar moves to January, Swisher finds himself without an MLB home. The Cleveland Indians are reportedly interested in Swisher as the Tribe offered a 4-year deal worth around $13M a season. Amidst the MLB Hot stove carousel Swisher has hinted at wanting to play with the Los Angeles Dodgers. With a jam-packed outfield as is, I have my doubts that the Dodgers would pull the trigger. On the other hand, the Texas Rangers are said to be in the hunt. Keep an eye out for the Rangers, who have been unusually quiet in the 2012 off-season.
With Josh Hamilton leaving for the divison rival Los Angeles Angels, the Rangers find themselves behind the eight-ball in the outfield. With RBI machine Adrian Beltre still lurking in the middle of this Texas lineup, Swisher would be able to pick up some of the slack left by Hamilton. Not to mention, this right handed-heavy lineup could be given a boost as Swisher can hit from both sides of the dish. In addition, Swisher can be stretched very thin in an already potent lineup. A potential, LF, RF, DH, or 1B Swisher would give Manager Ron Washington an ace in his sleeve at all time.
Production-wise, Swisher is no slouch. Two years removed from a 29HR and 89 RBI all star season, Ranger fans would welcome those numbers in a hitter-friendly ballpark in Arlington. 2012 saw Swisher tie a career-high in both RBI (95) and 2B's (36), all along with a .272. average. His offensive prowess could only help a depleted Rangers squad.
More importantly, Swisher has not been placed on the disabled list since 2005. A veteran run-producer who doesn't miss time sounds like a great pickup for a team who has lost key contributors like Mike Napoli, Michael Young and Hamilton. Look for Texas to make a move on the switch-hitting all-star.
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Oates enjoyed time in Washington, wants to keep coaching
May 10, 2014, 12:05 PM EDT
Adam Oates' career as a head coach hasn't gotten off to an ideal start, but he hopes being fired after two seasons with the Washington Capitals won't also serve as the end of his time as a bench boss.
When asked on the Fan 590 if he wants to return as a head coach next season, Oates didn't hesitate.
"Yes I would," Oates said. "I really really enjoyed it since I got into coaching in Tampa … working with the Caps was fantastic."
He helped Alex Ovechkin revitalize his game, resulting in the superstar forward winning the Rocket Richard Trophy in back-to-back campaigns. Ovechkin's resurgence also played a big role in the Capitals making the playoffs in Oates' first campaign as a head coach.
His sophomore season in 2013-14 didn't go nearly as well as the Capitals missed the playoffs for the first time since 2007.
"You can have an off year, if anything we had a bit of an off-year this year," Oates said. "We had a couple guys hurt, things didn't quite go the way planned."
He pointed to Randy Carlyle in Toronto as an example of a good coach having a rough campaign and praised Toronto's decision to extend him in spite of the Maple Leafs' late season collapse. He also brought up Mike Babcock, who didn't do particularly well in his sophomore season with Anaheim back in 2003-04.
Oates certainly wouldn't mind following in Babcock's footsteps as the former Ducks coach has gone on to do great things in Detroit and is a 2013-14 Jack Adams finalists.
Shero: Buying out Zubrus creates flexibility to add forward
Jul 29, 2015, 6:27 PM EDT
"It really wasn't about Dainius himself."
Got $1.5 million? Jim Craig is selling his 'Miracle on Ice' gold medal
Jul 29, 2015, 4:57 PM EDT
His collection can be had for $5.7 million.
Gillette Stadium will host Bruins-Habs alumni game ahead of Winter Classic
Jul 29, 2015, 3:31 PM EDT
The contest will air on Dec. 31 while the Classic itself is scheduled for 1:00 p.m. ET on Jan. 1.
Ryan Murray: 'I have to show up and prove it'
Jul 29, 2015, 2:28 PM EDT
Staying healthy would help, too.
Voynov serving sentence at jail that once advertised it had flat screen TVs
Jul 29, 2015, 1:22 PM EDT
The Seal Beach Detention Center isn't exactly Shawshank.
Campbell credits ECHL stint for turning his game around
Jul 29, 2015, 1:03 PM EDT
"I relaxed down there and came back with the same attitude and everything kind of took care of itself."
Zubrus on unconditional waivers for purpose of terminating his contract
Jul 29, 2015, 12:34 PM EDT
Veteran forward had just four goals and six assists in 74 games last season.
JayBo admits groin injury meant he 'couldn't do some of the things that I was used to doing'
Jul 29, 2015, 11:58 AM EDT
"So hopefully it's nothing that keeps coming back."
Talbot knows he has a 'great opportunity' in Edmonton
Jul 29, 2015, 11:09 AM EDT
Can he give the Oilers the goaltending they so badly need?
Report: Bernier and Leafs more than $2 million apart ahead of Friday's arbitration hearing
Jul 29, 2015, 10:21 AM EDT
The 26-year-old goalie is coming off a tough season.
Report: Rangers prospect Andersson headed to North America
Jul 29, 2015, 9:00 AM EDT
Spent last season with Lugano in the Swiss League.
PHT Morning Skate: 'Hawks fan hikes Machu Picchu, meets Jonathan Toews
Jul 29, 2015, 8:00 AM EDT
Y'know, everyday stuff.
Wild's Dumba asked Boogaard's family permission to wear No. 24
Jul 28, 2015, 10:30 PM EDT
Nice gesture.
Report: Visnovsky considering European options
Jul 28, 2015, 9:38 PM EDT
Potentially a move to Switzerland, or the Czech League.
Sabres name Cunneyworth AHL head coach
Jul 28, 2015, 8:39 PM EDT
Returning him to Rochester for a third time.
Orpik undergoes wrist surgery, should be ready for season opener
Jul 28, 2015, 7:39 PM EDT
Washington d-man is expected to miss the next two weeks of offseason training.
Canucks stay busy, ink Baertschi to one-year, one-way deal (Update: $900K)
Jul 28, 2015, 6:26 PM EDT
Swiss winger came over from Calgary at last year's deadline.
Flyers re-sign Couturier: six years, $26 million
Jul 28, 2015, 4:39 PM EDT
Nice payday after posting a career-high in goals this season.
For Pens, Tuesday's moves were all about depth and finances up front
Jul 28, 2015, 4:23 PM EDT
"When you look at the structure of our salaries and our cap, it's important to get those bottom-six cap hits in better shape."
Journeyman Steckel signs in German League
Jul 28, 2015, 3:21 PM EDT
With the Nurnberg Ice Tigers.
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text:
ATI launches Mobilty Radeon X700 for thin-and-light laptops
ATI has announced a new PCI Express-based graphics processor for laptops - the MOBILITY RADEON X700 that aims to provide better graphics and less power drain on a new range of laptops being released.
Partners already include all the major manufacturers including Acer, Arima, Asus, Alienware, BenQ, Clevo, Compal, ECS, Eurocom, Fujitsu, Fujitsu-Siemens, Gateway Inc, Inventec, Lenovo, LG, Medion, MSI, Samsung, Sony, Targa, Toshiba and Uniwill.
The chipset offers a wide range of features including:
- Eight parallel pixel pipelines and six programmable vertex pipelines for lightning fast graphics performance
- POWERPLAY 5.0 with new PCI Express based power management capabilities for longer battery life
- LRTC and LCD-EE for high-quality, crisp video playback on notebook panels
- Automatic Display Configuration technology for simplified setup of external displays
- High performance GDDR3 memory support
- A range of integrated memory options optimized for space and power efficiency on thin-and-light designs
How to appoint an heir on Facebook for when you die
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NASA discovers Earth 2.0: Here's what you need to know
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- Here are the first really up-close NASA pics of Pluto and its moons
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- Samsung's new camera sensor could make the Galaxy Note 5 snapper the best out there


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Robert's House and Hound Robert, a favorite attraction of Thaddeus
After you tour through Robert's house, you'll flow with the crowd into her Meet 'n' Greet Garage in the "back yard". There you can observe Robert repeatedly re-taping a scene from her last film, a shot-for-shot remake of Terms of Endearment. Be sure to ask her a silly question!
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Themed after a Bermudan seaside village, *Hilton Grand Vacations Club at SeaWorld International Cent
*Hilton Grand Vacations Club on International Drive* is in an excellent location one exit from the D
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Vatican forced to halt use of foreign credit cards within its borders
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en.romereports.com In a bid by Italian financial authorities against money laundering, starting January 1 the Vatican will no longer accept credit card payments for many of its services.
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Cold, Flu, & Cough Health Center
H1N1 Flu: Interim Guidance for People With Heart Disease, Stroke, or Cardiovascular Disease
In this article
Clinicians and health departments should see H1N1 Flu and Patients With Cardiovascular Disease (Heart Disease and Stroke): Interim Guidance and Considerations for Health Care Providers and for State and Local Public Health Agencies.
This document provides interim guidance and will be updated as needed.
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H1N1 Flu (Swine Flu): General Information
The information below is important for people with heart disease, stroke, and cardiovascular disease.
- Maintain a two week supply of your medications.
- Do not stop taking your medications without first consulting your health care provider, especially in the event of influenza or a respiratory infection.
- People with heart failure should be alert to changes in their breathing and should promptly report changes to their health care provider.
- It is especially important to wash your hands often with soap and water and follow other basic hygiene to avoid infection.
For More Information
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These authors contributed equally to this work.
Abyssomicins from the South China Sea Deep-Sea Sediment Verrucosispora sp.: Natural Thioether Michael Addition Adducts as Antitubercular Prodrugs†
Article first published online: 6 DEC 2012
DOI: 10.1002/anie.201208801
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 4, pages 1231–1234, January 21, 2013
Additional Information
How to Cite
Wang, Q., Song, F., Xiao, X., Huang, P., Li, L., Monte, A., Abdel-Mageed, W. M., Wang, J., Guo, H., He, W., Xie, F., Dai, H., Liu, M., Chen, C., Xu, H., Liu, M., Piggott, A. M., Liu, X., Capon, R. J. and Zhang, L. (2013), Abyssomicins from the South China Sea Deep-Sea Sediment Verrucosispora sp.: Natural Thioether Michael Addition Adducts as Antitubercular Prodrugs . Angew. Chem. Int. Ed., 52: 1231–1234. doi: 10.1002/anie.201208801
- †
This work was supported in part by the National Program on Key Basic Research Project (973 program, 2013CB734000, 2012CB725200, 2012CB721006), the National Natural Science Foundation of China (81102369, 30901849, 30911120483, 81102356, 30973665, 30911120484), the CAS Pillar Program (XDA04074000), the Ministry of Science and Technology of China (2011ZX11102-011-11, 2007DFB31620), Genzyme, a Sanofi company, the Institute for Molecular Bioscience, the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 312184, The University of Queensland, and the Australian Research Council (ARC LP0989954). L.Z. is an Awardee of the National Distinguished Young Scholar Program in China. We acknowledge Prof. Hans-Peter Fiedler (Universität Tübingen) for providing a sample of atrop-abyssomicin C for reference.
Publication History
- Issue published online: 15 JAN 2013
- Article first published online: 6 DEC 2012
- Manuscript Received: 2 NOV 2012
Funded by
- Funded Access
- National Program on Key Basic Research Project. Grant Numbers: 2013CB734000, 2012CB725200, 2012CB721006
- National Natural Science Foundation of China. Grant Numbers: 81102369, 30901849, 30911120483, 81102356, 30973665, 30911120484
- CAS Pillar Program. Grant Number: XDA04074000
- Ministry of Science and Technology of China. Grant Numbers: 2011ZX11102-011-11, 2007DFB31620
- Genzyme
- Institute for Molecular Bioscience
- Australian Research Council. Grant Number: ARC LP0989954
- natural products;
- prodrugs;
- polyketides;
- structure elucidation;
- tuberculosis
Tuberculosis (TB) is a leading cause of death in the world today, and is exacerbated by the prevalence of multi- (MDR-TB), extensively (XDR-TB), and totally (TDR-TB) drug resistant strains. Despite the threat to human health, existing frontline TB therapeutics remain constrained to a handful of vintage antibiotics prescribed in a combinatorial format to achieve efficacy. The current shortfall in antitubercular drugs demands urgent attention, to develop new antibiotics effective against all strains of tuberculosis.
In responding to this challenge, we screened a library of marine-derived bacteria (4024) and fungi (533) for growth inhibitory activity against Bacille Calmette Guerin (BCG), an attenuated strain of the bovine tuberculosis bacillus Mycobacterium bovis.1 BCG serves as a nonpathogenic but nevertheless valuable screening surrogate for the far more hazardous and pathogenic M. tuberculosis. Our screening detected 27 (0.6 %) extracts with anti-BCG activity, including a South China Sea deep-sea (−2733 m), sediment-derived actinomycete, Verrucosispora sp. (MS100128). Bioassay-directed fractionation of a large scale (21 L) culture of MS100128 yielded three new members of the rare class of abyssomicin polyketides, abyssomicins J (1), K (2), and L (3), and the four known2 abyssomicins B (4), C (5), D (6), and H (10) (Figure 1). All structures were assigned by detailed spectroscopic analysis, with the known abyssomicins 4–6 and 10 documented in the Supporting Information, and the new abyssomicins 1–3 discussed below.
The abyssomicins B–D (4–6) were first reported in 20042a,b from the deep-sea (abyssal) Verrucosispora sp. (AB-18-032), since proposed to be the new taxon Verrucosispora maris sp. nov.3 A subsequent 2007 reinvestigation2c of AB-18-032 led to three additional co-metabolites in the form of abyssomicins G (9) and H (10), and atrop-abyssomicin C (8). The deep-sea status of the abyssomicin chemotype was challenged by a 2007 report4 of abyssomicin E (7) from a Senegalese soil Streptomyces sp. (HK10381), a 2010 report5 of abyssomicin I (11) from a Mexican soil Streptomyces sp. (CHI39), and a 2011 report6 of ent-homoabyssomicins A and B from a German soil Streptomyces sp. (Ank 210). Ongoing interest in the synthesis, biosynthesis, and pharmacology of the abyssomicins has been fuelled by the observation that abyssomicin C (5), an inhibitor of p-aminobenzoic acid (p-ABA) biosynthesis (a putative molecular target for next-generation antibiotics),6 exhibits promising anti-methicillin-resistant Staphylococcus aureus (MRSA)2b and antitubercular7 activities.
HRESI-MS measurements on abyssomicin J (1) revealed an adduct ion ([M+Na]+) consistent with a molecular formula of C38H46O12S (Δmmu+0.4). Examination of the 13C NMR (CDCl3) data (see Table S1 in the Supporting Information) revealed only 19 carbon resonances, thus indicating symmetry. Further analysis of the NMR data revealed a high degree of similarity with those previously reported for abyssomicin D (6),8 with the most significant difference being the replacement of methylene C9 (δH=2.00/1.54 ppm, δC=26.1 ppm) in 6 with a thiomethine (δH=3.83 ppm, δC=41.1 ppm) in 1. Detailed analysis of 2D COSY, HMBC, and ROESY NMR correlations (see Figure S1 e in the Supporting Information) confirmed a common pentacyclic core between 1 and 6, with an HMBC correlation from H9 (δH=3.83 ppm) to C9 (δC=41.1 ppm), thus suggesting dimerization through a C9 to C9′ thioether bridge. A C9 β thioether configuration was assigned by comparing experimental data for H9 (J8,9=10.8 Hz; J9,10=3.6 Hz) with calculated values for energy minimized (MM2) in silico models of α (J8,9=6–7 Hz; J9,10<1 Hz) and β (J8,9=7–8 Hz; J9,10=3–4 Hz) thioethers,4 and with the literature data for abyssomicin E (7; J8,9=8 Hz; J9,10=4 Hz). Thus the complete relative stereostructure for 1 could be assigned as shown in Figure 1.
HRESI-MS measurements on abyssomicin s K (2) and L (3) revealed adduct ions consistent with molecular formulae (2: C19H24O7, Δmmu+0.8; 3: C20H26O7, Δmmu+0.5) attributed to the corresponding H2O and MeOH Michael addition adducts of 5. In support of this hypothesis, the NMR (CDCl3) data for 2 and 3 (see Tables S2 and S3 in the Supporting Information) proved to be very similar to those of 1, with significant differences being limited to replacement of the thiomethine in 1 (δH=3.83 ppm; δC=41.1 ppm) with a hydroxymethine in 2 (δH=4.81 ppm and δC 67.7 ppm), and a methoxymethine in 3 (δH=4.43 ppm and δC=76.7 ppm; OMe δH=3.30 ppm and δC=58.2 ppm). The 2D NMR data for 2 and 3 (see Figures S2 e and S3 e in the Supporting Information) also revealed diagnostic correlations supportive of the proposed structures.
Absolute configurations were assigned to 1–3 on biogenetic grounds, given that they are co-metabolites of 4–6 and 8, all of which have been assigned to a common antipodal series.2 Also supportive of this biosynthetic relationship, we demonstrated that 1–3 could be formed as Michael addition adducts of 5. For example, a sample of 5 exposed to 0.1 M Na2S resulted in near quantitative conversion into three products. The major product was identified as 1, while the minor products were identified as the intermediate thiol 12 and its oxidation product, the sulfonic acid 14 (Figure 2). By contrast, exposure of 5 to 0.05 M NaOH returned only a single product identified as 2, while exposure to 0.5 M TFA led to a mixture of 2 and the new isomer 15 (Figure 2 and Scheme 1). The structure for 15 was assigned by detailed spectroscopic analysis (see Figure S10 c in the Supporting Information), and its formation rationalized as an acid-mediated H2O Michael addition adduct of 5, but lacking the cascading second intramolecular Michael addition needed to form the caged-carbon skeleton of 2. Exposure of 15 to 0.05 M NaOH resulted in quantitative conversion into 2, while exposure of 5 to 0.5 M TFA in MeOH resulted in facile conversion into a single product, which was identified as 3 (see Figures S17 and S18 in the Supporting Information). Significantly, this latter transformation proceeded (albeit at a far slower rate) without exposure to acid, during handling/storage of 5 in MeOH. The observations listed above confirm that 1–3 are biosynthetically related to and are likely derived from 5, and reveal for the first time an acid-mediated strategy capable of accessing a new abyssomicin scaffold (i.e. 15).
To address the possibility that one or more of the compounds 1–3 were handling artifacts, a fresh EtOAc extract of a small-scale culture of Verrucosispora sp. (MS100128) was prepared and subjected to HPLC-DAD-MS analysis using MeCN/H2O, thus avoiding exposure to acid, base, and alcoholic solvents. This analysis detected all the compounds 1–3, as well as the metabolites 4–6 and 10, thus confirming their natural product status (see Figure S13 in the Supporting Information).
Among the known abyssomicins, only the atropisomers 5 and 8 have been attributed anti-TB properties—against the fast growing nonpathogenic M. smegmatis, the TB surrogate BCG, and M. tuberculosis (H37Rv)7—and thus emphasized the critical structure–activity importance of the Michael acceptor enone moiety.2a Given this history, we were initially surprised to discover that, along with 5, the thioether 1 was the principle anti-TB agent in Verrucosispora sp. (MS100128). Indeed, the anti-BCG activities for 1 (MIC 3.125 μg mL−1) compared favorably with those of 5 (MIC 6.25 μg mL−1; see Table S11 in the Supporting Information). To explain this apparent departure from the established Michael acceptor pharmacophore paradigm, we hypothesized that 1 was a natural prodrug undergoing in situ reverse Michael addition to deliver an abyssomicin anti-TB antibiotic (presumably 5 and/or 8). As 1 was stable during isolation and handling, we speculated that the reverse Michael addition process required activation by in situ enzymatic oxidation (i.e. P450). This view was based in part on a review of the literature, which confirmed that P450 enzymes can transform thioethers by way of sulfoxides into sulfones, and that sulfones can undergo a reverse Michael addition. For example, the synthetic vasodilator thioether flosequinan sulfide is transformed by rat and human liver P450 enzymes into its sulfoxide and sulfone,9 while cancer cell enzymatic oxidation of the synthetic thioether prodrugs of brefeldin yield sulfones, which in turn undergo rapid reverse Michael addition to deliver brefeldin.10 In yet another example of sulfone-mediated reverse Michael addition, the semisynthetic sulfone antibiotic dalfopristin undergoes metabolism in human plasma to give the natural product Michael acceptor pristinamycin IIA.11 These examples notwithstanding, based on our hypothesis, 1 would represent the first example of a natural thioether adduct (dimer or otherwise) which serves as a prodrug for its associated Michael acceptor.
To test this hypothesis in vitro, a MeCN/H2O solution of 1 was treated with the oxidizing reagent Oxone (as a chemical P450 surrogate)12 to yield four products identified by spectroscopic analysis as the sulfoxide 18, sulfone 19, sulfonic acid 14, and atrop-abyssomicin C (8). The sulfoxide 18, identified by HPLC-DAD-HRESI-MS, proved unstable to handling as it undergoes rapid air oxidation to the sulfone 19. Likewise, although the sulfone 19 was sufficiently stable for 1H NMR analysis, when it was handled in MeCN at 40 °C (1 h) it underwent a reverse Michael addition to yield 8, together with four minor intermediates. The latter products were identified by HPLC-DAD-ESI-MS as the sulfinic acids 13 and 16, and the sulfonic acids 14 and 17. Although a sample of 14 could be purified and characterized by 1H NMR spectroscopy, even short (10 min) exposure to MeCN at room temperature led to equilibration of a 14/17 mixture, and heating to 70 °C (12 h) transformed this mixture into 8. Notably, after oxidative activation by Oxone to form the sulfoxide 18, all subsequent transformations leading to 8 could be accommodated by air oxidation and inherent chemical reactivity. Based on these observations, a plausible mechanism for the transformation of 1 into 8, inclusive of the intermediates 13 and 14 and 16–19, is illustrated in Scheme 2 (see Figures S19–21 in the Supporting Information). In this mechanism, the formation of the single atropisomer 8 (i.e. no trace of 5) was particularly interesting and prompted closer examination.
To better understand the chemical and biological significance of atropisomer selectivity in the reverse Michael addition transformation of 1 into 8, we carried out analytical studies on the Michael acceptors 5 and 8. Nicolaou and Harrison demonstrated,13 and we have independently confirmed (see Figures S12 a and S12 b in the Supporting Information), that 5 and 8 equilibrate under anhydrous acid-mediated conditions (e.g. CDCl3). Importantly, as this equilibration was not evident under nonanhydrous in vivo conditions, we reasoned that 5 and 8 acted independently as anti-TB agents, with an antibiotic potency correlated to their respective strengths as Michael acceptors. Building on this hypothesis, and having established 8 as the sole atropisomer arising from a reverse Michael addition, we reasoned that 8 was optimally configured as a superior Michael acceptor (compared to its atropisomer 5). To test this hypothesis, separate MeCN/H2O solutions of 5 and 8 were exposed to 0.1 M TFA to initiate an acid-mediated Michael addition leading to 15. A time course (18 h) analysis clearly established 8 as a far more potent Michael acceptor (Figure 3), and is consistent with its prior history as a superior antimicrobial agent.2c, 13 The high Michael acceptor potency of 8 also suggested a low in vivo half-life. Consistent with all of the above, we detected low levels of 8 in BCG cells exposed to 1 (see Figure S25 in the Supporting Information).
In summary, our investigations into the anti-TB properties of the South China Sea deep-sea Verrucosispora sp. (MS100128) led to the isolation, identification, and anti-TB evaluation of new (1–3) and known (4–6, 10) abyssomicins. Structures were assigned to 1–3 on the basis of detailed spectroscopic analysis, biosynthetic considerations, mechanistic studies, and semisynthesis from the co-metabolite 5. Detailed analytical studies into abyssomicin Michael addition chemistry informed our understanding of the chemical reactivity, stability, and anti-TB properties of this rare structure class. We established 8 as a far more potent Michael acceptor than 5, and used this to rationalize its superior antibacterial properties. We transformed 5 into the Michael adduct 1 and used both in vitro and cell-based analytical studies to demonstrate that 1 can act as a prodrug, thus responding to oxidative activation to selectively deliver the anti-TB antibiotic 8.
Our studies make a contribution beyond the specifics of the abyssomicin pharmacophore by drawing attention to the possible utility of thioether Michael addition adducts as a means to stabilize highly reactive Michael acceptors, thereby enhancing bioavailability and improving therapeutic potential. The thioether Michael adduct prodrug concept, inspired by abyssomicins from the South China Sea, offers a promising new approach to "chemically package" bioactive Michael acceptors, thus improving their chances of being developed into clinically useful drugs.
- 1
- 1aProc. Natl. Acad. Sci. USA 2007, 104, 4606–4611;, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
- 1bNat. Prod. Rep. 2010, 27, 1709–1719., , , , , , ,
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- 2aAngew. Chem. 2004, 116, 2628–2630; Angew. Chem. Int. Ed. 2004, 43, 2574–2576;, , , , , , , , , ,
- 2bJ. Antibiot. 2004, 57, 271–279;, , , , , , , , , , , ,
- 2cJ. Antibiot. 2007, 60, 391–394., , , , , ,
- 3Antonie van Leeuwenhoek 2012, 101, 185–193., , , , , , , , ,
- 4Org. Lett. 2007, 9, 2437–2440., , , , , , ,
- 5J. Nat. Prod. 2010, 73, 1943–1946., , , , , , , , ,
- 6Org. Lett. 2011, 13, 2156–2159., , , , ,
- 7Tuberculosis 2010, 90, 298–300., , , , , , ,
- 8Germany), WO2005033114A1, 2005., , , , (
- 9Drug Metab. Dispos. 1997, 25, 716–724., , , , , ,
- 10J. Med. Chem. 1998, 41, 3337–3346., , , , , ,
- 11J. Chromatogr. B 1998, 708, 161–168., , ,
- 12Tetrahedron Lett. 1981, 22, 1287–1290., ,
- 13Angew. Chem. 2006, 118, 3334–3338; Angew. Chem. Int. Ed. 2006, 45, 3256–3260., ,
Supporting Information
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Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.


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This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
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Recent Gulf Coast reviews
"The listing description was accurate regarding the location, layout and amenities. Easy to get in and unit was well equipped. The property was clean and well-maintained. The owner provided quick and good customer service. The beach is very close, the pool and hot tub are excellent and the property was great and very safe with many friendly and helpful security guards on site. We highly recommend this property for a family friendly vacation."Guest: ROB S. Date of Stay: June 2015 Review Submitted: July 8, 2015View listing
"Our family had a great vacation at Sangria. Well equipped for our family of 5. Perfect location, awesome view from the balcony, and beach chairs/umbrella, boogy boards included with the room. Kitchen had everything we needed, and Wifi worked well. Chad was very gracious in offering a military discount, which made booking this condo an easy decision. We will be back."Guest: Brett Date of Stay: May 2015 Review Submitted: May 11, 2015View listing
"We just returned from a week at the lazy dog escape and we highly recommend it! The location is absolutely fantastic and the house very comfortable. Incredible views of the ocean. The beach club and pools were a definite bonus. We hope to return in the near future."Guest: Rbp Date of Stay: July 2015 Review Submitted: July 19, 2015View listing
"Brought a whole van full of kids for a quick getaway. This house couldn't have been more perfect. From just lounging around on the decks, watching fish jump out of the water, to having plentiful bed space for everyone to get a good night's rest, the home was awesome. The beach is right around the corner: you could easily walk to it, but taking a vehicle was better (coolers, umbrellas, etc... stuff gets heavy!). Neighborhood was nice and surprisingly quiet. A word of advice to future guests: make sure to pick up ALL of your supplies in Galveston proper on the way in, because it is about 25 min away. Doesn't sound like much, but having to make multiple runs to town to pick up extra supplies takes hours away from relaxation time. There is a small convenience store in walking distance, but it is limited. That aside, we cannot wait to go back!"Guest: Dennis Date of Stay: June 2015 Review Submitted: June 17, 2015View listing
Featured Destinations: Smith Mountain Lake Rentals, Kiawah Island Rentals, Broken Bow Cabins, Port Aransas Condos


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People tend to check in during these times:
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Bartender Chris is awesome
Awesome dive bar. Great drink prices.
Improv tonight was subpar. Mike was awesome.
free indie music every tuesday
Half off drinks every Tuesday... You can run and tell that!!
I love this place,but when there is not a show going on. They have half off drinks every tuesday which is usually when I go.


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1982 Ford Mustang Spoiler
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- T5i® Cobra Style Rear SpoilerFord Mustang 1982, Cobra Style Rear Spoiler by T5i®. Your car will have a more dynamic look with this custom designed rear spoiler. It will enhance your car's appearance, if not its aerodynamics, without looking like an add-on...Custom high performance designMade from Fiberglass$248.83 - $365.73
- Duraflex® Demon Style Rear Wing SpoilerFord Mustang Hatchback 1982, Demon Style Rear Wing Spoiler by Duraflex®. Add style and performance to your car with this Wing. Its aggressive style will draw everyone's attention and it will add downforce at speed.$143.10
- Seibon® GT-Style Carbon Fiber SpoilerUniversal GT-Style Wing Carbon Fiber Spoiler by Seibon®. Give your car a high-tech aerodynamic look with this carbon fiber rear spoiler. Besides looking great, a rear spoiler can increase downforce for better traction. Whether...Finished in glossy clear coat that will not chip or flakeAerodynamically designed$612.00 - $901.00
- Spec-D® Double Deck Rear SpoilerUniversal Double Deck Rear Spoiler by Spec-D®. From small custom lip spoilers to universal adjustable double deck wing spoilers, Spec-D has a spoiler that's just right for your ride, in a range of materials including carbon fiber...Custom styles to suit every taste and purposeCan improve vehicle aerodynamics depending on spoiler and vehicle$97.90
- Duraflex® Rear Wing SpoilerUniversal Rear Wing Spoiler by Duraflex®. Add style and performance to your car with this Wing. Its aggressive style will draw everyone's attention and it will add downforce at speed.$122.40 - $179.10
- Carbon Creations® Carbon Fiber Wing Trunk Lid SpoilerUniversal Carbon Fiber Wing Trunk Lid Spoiler by Carbon Creations®. Add style and performance to your car with this Wing. Its aggressive style will draw everyone's attention and it will add downforce at speed.$399.00 - $519.00
- Extreme Dimensions® NT-5 Wing Trunk Lid SpoilerUniversal NT-5 Wing Trunk Lid Spoiler by Extreme Dimensions®. 3 Pieces. Dimensions are: 57" tip to tip, 8" height. Add style and performance to your car with this Wing. Its appearance will draw everyone's attention and it will add...$239.00
Guides & Articles
Michael GrayenAre Body Kits for Show or for Go?
There are body kits that are very carefully designed to control the airflow around the car, and there are body kits made to give the car a racing look, a look that not necessarily is more aerodynamic than the original but gives a performance character to the vehicle. It is more a choice between a kit that provides the best look per dollar and a kit that provides...
Michael GrayenWhat Type of Body Kit Material Should I Choose?
Regardless of the body kit material you choose, the end result will only be as good as the quality of the installation. Fiberglass parts are relatively easy to produce and inexpensive to buy, but their fit and finish as delivered is not as good as parts made from polyurethane or ABS plastic. Polyurethane is another popular material for body kit parts. Let's take...
Timothy ZahlWhat Kind of Spoiler is Right for You?
A spoiler is intended to control the way the air streaming over the car is affecting the rear of the vehicle. Spoilers cause drag, and actually slow the car down or make it unstable, if not properly designed. A correctly designed spoiler can counteract the lifting forces that most cars experience when speeds get high, and keep the car on the road.
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2009 Ford Mustang | Posted by Mark | (Dallas, TX)
These fenders are awesome, and best of all, they fit right out of the box. If you have vertical doors, you will have to make some adjustments but it's not hard and it will sharpen your skills.
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Weather News
Pilbara communities give mixed reaction for Cyclone ChristineWednesday January 8, 2014 - 17:18 EDT
Port Hedland's Port Authority says Cyclone Christine had little impact on the town's export operations.
Nearly 30 million tonnes of product passed through the Port last month, a 12 per cent increase on December 2012.
The facility was closed during the cyclone, which lashed the towns of Wickham and Roebourne earlier this month.
Meanwhile, rain associated with the cyclone has topped up a Pilbara dam.
The Harding Dam is the preferred source for the West Pilbara Water Supply Scheme, which supplies water to customers in Karratha, Dampier, Roebourne, Wickham and Point Samson.
The Water Corporation says the dam began overflowing on New Year's Eve, but stopped earlier this week.
However, the West Pilbara Water Supply scheme is currently being fed by the Millstream Aquifer due to a power failure at the dam caused by the cyclone, which is still being restored.
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Cold snap could see snow fall as low as sea level in Hobart on Monday
Weather forecasters are predicting snowy conditions across Tasmania over the weekend with the chance of snow falling in Hobart on Monday.
Storm warning for parts of southern WA extended to Perth metropolitan area
An unusual weather pattern is bringing storms to parts of southern Western Australia, with residents in the Central West, Lower West, Great Southern and Central Wheatbelt districts told to brace for damaging winds and possible flash flooding.
Winter winds bring a chill to Melbourne
While northern parts of the country have experienced unseasonably warm temperatures, winter is business as usual in the south.


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Wall Colors, Curtains Rods, Blue Wall, Hanging Curtains, Master Bedrooms, Burlap Curtains, Dark Wall, Linens Curtains, Accent Wall
Casey's Loft Life — House Tour
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Draperies. Depending on the windows/ doors you have, you could create some unbleached muslin panels and edge them with light blue gross grain ribbon. Tab curtains will read more primitive, pleated ones more formal. I wouldn't use tie-backs, but would extend rod far enough past window for panels to gather and not be in the way. Hanging the rod as high as possible will create more height.
$15/pair. This might be a little wacky, but I'm thinking these could work with selected leaves and birds colored in (with paint or (more likely) sharpie) in my accent colors. These are so cheap. Is it worth a try?
I have a vintage-looking white curtain styled like this over my master bathtub--love the romance of it
Cute curtains... Like the style.would be good for a little girls room Reasonable custom order Chrisiduman1@gmai...


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A foundation class of 14 will be enshrined in the new Lone Star Park Hall of Fame April 21—as part of the year long celebration of Lone Star Park at Grand Prairie's 10th anniversary. Lone Star Park's spring Thoroughbred season opens for a 16-week run April 12 and will continue through July 29.
The Hall of Fame class includes 1997 horse of the meeting Anet; former Lone Star Park all-time win leader and 1997 leading jockey Ronald Ardoin; Lone Star Park's eight-time leading trainer and all-time win leader Steve Asmussen; Quarter Horse trainer Jack Brooks, who saddled six winners in the Texas Classics; three-time Eclipse Award-winning trainer Bob Baffert, who has won Lone Star Park stakes races with major players; regular customer and horseplayer J.S. "Ponti" Campagna; original Lone Star Park investors the Trammell Crow family; four-time leading owner Tom Durant; Grand Prairie Mayor Charles England; former Lone Star Park president Corey S. Johnsen; Texas Thoroughbred and Quarter Horse owners and breeders Jim and Marilyn Helzer; former Lone Star Park chairman Robert L. Kaminski; Kool Kue Baby, winner of a 25 AQHA stakes races; and Mocha Express, the 1998 horse of the meet and two-time Lone Star Park Handicap winner.
The foundation class will be permanently enshrined with raised letters above the saddling area in Lone Star Park's paddock April 21.
"The creation of the new Lone Star Park Hall of Fame is a perfect complement to our year long celebration of Lone Star Park at Grand Prairie's 10th anniversary," said Darren Rogers director of communications at Lone Star Park. "This outstanding foundation class, whose accomplishments and reputations will withstand the test of time, will set the standard for all future inductees."
Lone Star Park to Recognize Hall of Fame Class
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Who was Kateryn Parr, Henry VIII's last wife? Faithful wife and scholarly queen, or a heretic and disloyal, faithless citizen before the Tudor court?
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The Lawson quins were a medical miracle and a national obsession. Samuel, Lisa, Deborah, Shirlene and Selina turn 50 on 27 July 2015. Their early childhood was idyllic, but when their parents' marriage broke up, their mother married a man who terrorised them for eight years befor ...
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My husband and I took a group class with Chef Andrea this June during our honeymoon and it was excellent. Cooking Classes in Rome came highly recommended from several reputable...
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3 Days in Rome
The Eternal City, for dummies...
Rome: A traveler's guide
My husband and I took a group class with Chef Andrea this June during our honeymoon and it was excellent. Cooking Classes in Rome came highly recommended from several reputable sources, but our class truly exceeded our expectations. Not only did Chef Andrea give us several useful tips during the preparation of our four course meal, but he taught us...
Chef Andrea & Cooking Classes in Rome was one of our favorite experiences during our trip to Italy. Learning about the food and culture of Italy, as well as getting hands on experience with a small group was priceless. By the end of the class, we were all enjoying the food, the wine. and the new acquaintances. I would highly...
My 13 year old son, my friend and I took Chef Andrea's cooking class in Rome. It was such a blast. Since my son enjoys cooking, I thought this would be a good experience and it far exceeded my expectations. Not only was the food we prepared great, we learned some great information and helpful tips. The wine was excellent...
This class was fabulous! Perfect for any level of cooking experience, Chef Andrea makes everyone feel at home in his kitchen. Learning about the food of the region was very interesting (e.g., like why gnocchi is made on Thursdays) and Chef's cooking tips have been very helpful since I've been home. Our menu was exciting and used the most beautiful...
Our family and friends (4 adults and 3 teenAgers) spent nearly a month traveling through Europe. On our last day in Rome we took the cooking class with Chef Andrea!This was truly the highlight of our trip!!
Chef Andrea does it right! He was easy to reach by email before the trip and he scheduled our class. We arrived to...
My two daughters and I signed up for a 1 day cooking class with Andrea Consoli, owner & Executive Chef of Cooking Classes in Rome. It was the best time we had! We stayed in Trestevere, and it turned out the cooking school was only a few blocks away. Andrea captained our class, which had experienced and inexperienced cooks from...
I would urge anyone to book this class if you have any spare time in Rome! What a wonderful day, chef Andrea really makes you feel welcome and the people we met on the course were also lovely and from different areas of the world. My husband commented that it was the best food that we ate the whole trip...
We had a great time at this cooking class. You get to spend a lot of time talking to the other members of the class before it begins and after while eating what you have cooked. The recipes are emailed to everyone at the end of the class as well. We greatly enjoyed the different foods that were cooked and...
We had a wonderful time with Chef Andrea for a day. It was very fun to learn how to cook a couple of "real" Italian dishes. This was a highlight of our time to Rome. We will be back!
My wife and I decided to take a Cooking Class while in Rome and after reading the reviews we chose, Chef Andrea Consoli's class. We were not disappointed. The class had a maximum of 12 people from all over the world, which made it extremely enjoyable. Andrea has such a great personality and is an outstanding teacher. Skill levels in...
Register now for free — and start getting automatic notification of new reviews, responding to traveler feedback, adding new photos to your listing and much more.
Gluten-free options?
Pick up at our hotel?
Returned to our hotel?
Clothing required?
How much does this activity cost, per person? Thanks!
What is the name of the cooking school/class and does it have a website we can register on?
Sorry I can't see a way of finding your web page' for booking etc
Dear Chef Andrea-
What is the email address or website to contact you? There are many, many fantastic reviews, but I can't figure out how to contact you?
See all questions


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El Paso Newswire (Page 9)
Comprehensive Real-Time News Feed for El Paso, TX. (Page 9)
Results 161 - 180 of 102,611 in El Paso, TX
Rymer Liriano of the El Paso Chihuahuas swings at a pitch against the Tacoma Rainiers Tuesday night at Southwest University Park. After going 9-3 on their post All-Star break road trip, the El Paso Chihuahuas were hoping to keep the hot play intact on their return trip to Southwest University Park. Comment?
Clinica Guadalupana to open in Agua Dulce colonia w/Photo
People in the low-income area of Agua Dulce will once again have a medical clinic because of Project Vida. The nonprofit community agency, which has eight other clinics, received a $440,000 grant from the U.S. Department of Health & Human Services/Health Resources & Services Administration to refurbish and reopen Clinica Guadalupana in far east of El Paso. Comment?
Old Dominion looks to continue rise with young team w/Photo
Old Dominion running back Ray Lawry runs around UTEP's Roy Robertson-Harris during their NCAA football game Saturday, Oct. 11, 2014, at the Sun Bowl in El Paso, Texas. For four of its six years, Old Dominion's formula for success was as simple as letting star quarterback Taylor Heinicke make plays. Comment?
El Paso Chihuahuas' seven-game winning streak comes to end w/Photo
Rymer Liriano of the El Paso Chihuahuas swings at a pitch against the Tacoma Rainiers Tuesday night at Southwest University Park. After going 9-3 on their post All-Star break road trip, the El Paso Chihuahuas were hoping to keep the hot play intact on their return trip to Southwest University Park. Comment?
Mexico sentences 5 men to 697 years for killings of 11 women w/Photo
... subjected them to human trafficking and forced prostitution before killing them. Ciudad Juarez, which is across from El Paso, Texas, was the scene of a series of eerily similar killings of more than 100 women beginning in 1993. Those possible serial ... 6 comments
5 men sentenced to 697 years in prison for killing 11 women in Mexico w/Photo
... subjected them to human trafficking and forced prostitution before killing them. Ciudad Juarez, which is across from El Paso, Texas, was the scene of a series of eerily similar killings of more than 100 women beginning in 1993. Those possible serial ... Comment?
Sulaiman: Chavez Jr. Too Heavy, Can Still Be Champ
World Boxing Council President Mauricio Sulaiman was not very impressed with the recent performance by former WBC middleweight champion Julio Cesar Chavez Jr., who return on July 18th in El Paso, Texas and won a ten round unanimous decision over Marco "Dorado" Reyes. Chavez Jr-Reyes was originally set for 168-pounds. Comment?
Governor Abbott Appoints Three To Texas Credit Union Commission
Yusuf Farran is an Energy Solutions Engineer at Johnson Controls, Inc. in El Paso. He formerly served as executive director of facilities at the Canutillo Independent School District. Comment?
... Madrid, a supervisory agent, was arrested on "alien smuggling charges" at about 8 a.m. on Friday at his home in El Paso after a criminal complaint led to an investigation by the Department of Homeland Security, DHS officials said in a statement. He ... 2 comments
City of El Paso ends fiscal year in the black w/Photo
El Paso city officials said Tuesday that the city's finances are ending the current fiscal year on a positive track while projections are calling for a stable budget picture compared to past years. City Rep. Cortney Niland credited City Manager Tommy Gonzalez for improving customer-based city services and operating the budget in the black. 1 comment
El Paso startup Premier Biomedical looking for partners in Brazil w/Photo
Premier Biomedical Inc., an El Paso start-up co-founded by an El Paso doctor, will use a Brazilian health-care consulting firm to help it find financing and partners in Brazil to take its medications and medical devices to market there, officials announced Tuesday. Francisco Brocco, managing partner of the consulting firm, "and his staff have the drive and connections to find the most suitable joint venture partner for us in Brazil," to bring Premier's products to the entire South American market, William Hartman, Premier CEO, said in a statement. Comment?
El Paso county warns of impending UMC tax hike w/Photo
The county of El Paso warns a tax increase "most probably will" come due to the mounting debt the El Paso Children's Hospital maintains against the county hospital, University Medical Center. In a document filed Tuesday in bankruptcy court, the county explained UMC provides $33,000 per day in services to the Children's hospital. Comment?
El Paso Chihuahuas pursuing hosting Triple-A All-Star Game as soon as possible w/Photo
The El Paso Chihuahuas front office has made it clear this week that they are pursuing the possibility of hosting the Triple-A All-Star Game in El Paso sometime in the next few years. "The Chihuahuas have expressed an immediate interest in hosting that game as soon as we can get it," Chihuahuas general manager Brad Taylor told ABC-7. Comment?
Local scouters respond to openly gay leadership decision w/Photo
... learning to never let an adult and child be alone together or to share tents between adults and scouts. While the El Paso area Yucca Council of the BSA declined to comment on the issue, they did send ABC-7 a statement that said "On July 27th, the ... Comment?
GOP official, former El Pasoan ousted over anti-Trump pinata Santa Fe party w/Photo
... he organized the event last week to allow residents to hit a pinata that bore Trump's likeness. Padilla, a former El Paso city representative, says he was exercising his right to free speech and believes Trump's previous comments about Mexican ... 6 comments
Abandoned puppies left in dumpster need new home w/Photo
... separated from their mother at just 3 weeks old. Julie Gomez is a customer service associate with the Humane Society El Paso " They put a new meaning to the phrase one mans trash is another mans treasure; I don't understand how someone can throw ... Comment?
5 Things D.R. Horton's Results Tell Us About the New-Home Market w/Photo
... to wane from this year's first quarter to the second. Alex Barron , president of the Housing Research Center , an El Paso, Texas, firm that tracks home-builder stocks, notes that builders D.R. Horton, PulteGroup Inc. , M/I Homes Inc. and NVR Inc. ... Comment?
Natural Gas Climbs for Second Day on Outlook for Scorching Heat
... to electricity generators were up 25 percent from a year ago through Tuesday, according to LCI Energy Insight in El Paso, Texas. Power-plant demand for gas may jump 13 percent this year to 25.22 billion cubic feet a day in response to low prices, ... Comment?
Roadrunner Acquires Stagecoach For Cross-Border Services
Roadrunner Transportation Systems has acquired Stagecoach Cartage and Distribution for $35 million plus an earn-out capped at $5 million, the company announced. Stagecoach is a provider of truckload and logistics services based in El Paso, Texas with regional, intermodal and over-the-road truckload services throughout the southwestern U.S. and Mexico. Comment?
Attorney Juan L. Guerra, Jr Selected for Investigative Committee Following the Death of Sandra Bland
... will be instrumental in reviewing the department's policies, procedures, and personnel. PRLog - July 28, 2015 - EL PASO, Texas -- The request comes just a few weeks following the death of 28-year-old Sandra Bland, who was pulled over on a routine ... Comment?
Copyright © 2015 Topix LLC


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Nike LeBron 9 Shoes Ads (Design Explorations)
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Friday, July 31
Ma'an TV
Gaza Strip
Middle East
Latest News
'PKK attack' kills 2 police in tense Turkey
Local official: 10 killed in Boko Haram attack in Nigeria village
Tunisia extends state of emergency by 2 months
Erdogan slams claims of Turkey IS cooperation as 'black propaganda'
Trial results: Vaccine offers 100% Ebola protection
Abbas wants ICC to probe arson that killed Palestinian toddler
WikiLeaks: US spied on Japan government, companies
Female suicide bomber blows herself up in NE Nigeria market
Libya's UN envoy to discuss peace plan with rival lawmakers
Fears of humanitarian crisis in Serbia as refugees stream in
Pentagon denies US-trained rebels captured in Syria
Egypt, Saudi sign pact to boost military ties
IMF approves $1.24 bn Iraq emergency lifeline
Humanitarian chief: Yemen blockade 'killing' civilians
Turkey probes Kurdish leader, ramps up air strikes against PKK
Israel PM calls Palestinian toddler death 'act of terrorism'
PLO holds Israel government 'fully responsible' for toddler's death
IMF approves $1.24 bn Iraq emergency lifeline
Egypt, Saudi sign pact to boost military ties
Embassy: US delivers F-16s to Egypt ahead of Kerry visit
'Patriarch could become persona non grata in Bethlehem'
Jan. 6, 2010 10:33 A.M. (Updated: Jan. 8, 2010 8:47 A.M.)
Bethlehem – Ma'an – A group of prominent Greek Orthodox Palestinians threatened on Wednesday to split from their church over the sale of West Bank land to Israel.
Marwan Toubasi, the deputy minister of tourism and the organizer of a protest movement, made the pronouncement at a news conference in Bethlehem's Manger Square on Wednesday, as Orthodox Christians marked Christmas Eve. Leader of the Greek Orthodox Club of Beit Sahour Dr Elias Isaid, however, said a split from the church was "unrealistic."
"Today's demonstration is the start of our action against the patriarch," Isaid commented, and if the concerns of the Palestinian parishes are not met, "we are prepared to declare the patriarch a persona non grata in Bethlehem."
Approximately 300 protesters rallied in Manger Square, holding signs condemning the actions of the patriarch. "The Holy Land is not for Sale or Lease," one banner said, "Theophilos = Irenais" said another, likening the new patriarch to the sacked former leader he replaced.
Those protesting were part of the Council of Arab Orthodox Institutions and Organizations in Palestine, representing 19 groups across the country. Greek Orthodox Palestinians are angry over promises made by the patriarch in 2005 when he was appointed, centering on the creation of a more consultative process that includes Palestinians and Jordanians in an effort to prevent further long-term land leases to Israeli developers.
Scout bands welcomed the Syrian and Coptic patriarchs into Manger Square with much fanfare, but packed up their drums and bagpipes ahead of the arrival of Theophilos. Silence filled the square ahead of his arrival, broken by a car from the partirach's office blaring Christmas music, which drowned out the boos of protesters.
Theophilos was walked in to the church surrounded by officials and a cordon of riot police, who linked hands and formed a human barricade between the booing protesters and the patriarch.
Protest supporters shouted condemnations at Theophilios, saying he failed to implement a pledge to reverse past sales, and angry accusations over recent land deals. Church land has been used to build Israeli settlements, including Har Homa and Ma'aleh Adumim, the protesters say.
"We are starting the demonstrations against the patriarch now," said Isaid.
A PLO official recently told a Greek newspaper that the land deals were "treacherous agreements made with the Patriarchate which are contributing to the cutting off of East Jerusalem and Bethlehem from the Palestinian hinterland."
The Council of Arab Orthodox Institutions also asked the Palestinian Authority to intervene and nullify the land sales.
The Greek Orthodox make up the largest denomination of Palestine's Christian minority.
Israeli artists up in arms over culture minister remarks
Vatican recognition of saints symbolic victory for Palestinians
Abbas calls on Palestinian Christians to 'stay with us'
Palestinians mark 67th Nakba anniversary in Ramallah festival
Most Read
Israeli forces, right-wingers storm Aqsa Mosque compound
July 26, 2015 | 43
Palestinian teen 'executed' during arrest, family says
July 27, 2015 | 29
Israeli settlers kill Palestinian toddler in arson attack
July 31, 2015 | 15
Israeli forces kill Palestinian teen during arrest raid
July 27, 2015 | 7
Violence against Palestinian child detainees on rise
July 25, 2015 | 8
Ma'an News Agency
All rights reserved © 2005-2015


text:
Wilson, Sons report increase in towage, offshore revenues during first quarter 2012
The Company recorded Net Revenues of USD 157.2M, in line with 1Q11 figures. There was, however, healthy increase in Towage (up 34,9%) and Offshore (up 12,5%), due to better pricing and an increase in the number of vessels in operation.
Currently, the Company has 3 tugboats and 5 PSVs in different phases of construction at the Guaruja Shipyard. The strategy to increase and renew its fleet is part of the Company's desire to meet the demand in the oil & gas industry and international trade flow.
The new Guaruja II shipyard, the new Offshore and Towage vessels, and Tecon Salvador's expansion works are the major contributors to the quarterly CAPEX of USD 43.0M.
"2012 is a year to celebrate the expansion of Tecon Salvador and Guaruja II Shipyard: the first will increase the present capacity from 300,000 to 530,000 TEU per year; the second will increase the processed steel capacity from 4,500 to 10,000 tons per year", said Cezar Baiao, CEO of Operations in Brazil.
The quarter saw a decrease of 28.3% in YoY EBITDA mainly due to the end of the Petrobras public port operations in Rio de Janeiro in October 2011 and represented approximately 30% of Brasco's 1Q11 EBITDA, and to the negative impact of the Long-Term Incentive Plan, which had been positive in 1Q11 and was negative in 1Q12, therefore recording a net variation of US$ -11.1M. Furthermore, the Logistics business discontinued 10 low-margin operations, and the Salvador port terminal was constrained by its on-going expansion works.
DryShips Inc. (NASDAQ: DRYS), a global provider of marine transportation services for drybulk and petroleum cargoes, and through its subsidiary, Ocean Rig UDW Inc.
In what is being seen as a landmark decision, Hill Dickinson is the first law firm to have successfully defended a UK class action case involving a Norovirus outbreak onboard a cruise liner.
MHI gives Notice Regarding Conclusion of Absorption-type Split Agreements Relating to Transfer of Ship Construction and Hull Block Manufacture Businesses to Two
One of the largest Italian tug owners, Fratelli Neri S.p.A, ordered its first Damen tug, an ASD 3212, on 21 July 2015.
The vessel will be the first ASD tug
The Royal Thai Navy claims it urgently needs more submarines to compete with other Asian countries.
The assistant commander made the claim aimed at persuading
NOIA President Randall Luthi issued the following statement on the Senate Energy and Natural Resources Committee's passage of the OPENS Act, which will open new
Shell Oil's icebreaker MSV Fennica weaved through nine remaining protesters hanging from the St. Johns Bridge and made its way toward the Pacific Ocean.
James Troop supplies two new Volvo Penta engines to upgrade Mersey pilot boat
Merseyside-based engine specialist James Troop & Co has secured a deal to supply
As one of the top global carriers Hapag-Lloyd offers a comprehensive service network and will add port of Halmstad, Sweden to the Nordic Short Sea Network.
BBC Chartering announces the opening of a new representative office in Ho Chi Minh City, Vietnam, starting August 1st breakbulk, and general cargo transportation
China and Southeast Asian nations have agreed to set up a foreign ministers' hotline to tackle emergencies in the disputed South China Sea, a senior official of
Protesting ferry-workers blocked road access to the northern French port of Calais with burning tyres on Friday, police said.
The workers have in recent weeks


text:
NPR News
A Wedding And A Challenge: Lebanese Couples Fight For Civil Marriage
No one ever said marriage was easy, but in Lebanon, it's even harder: The country has 15 sets of matrimonial laws for 18 different religions and sects. Activists want the right to civil marriages.
Pipeline Operator: Possibly Months Before Cause Of Calif. Spill Found
Plains All American, the company that operates the pipeline, says it has yet to uncover the problem. So far, 9,000 gallons of sludge have been removed from a nine-miles stretch of Calif. coast.
Islamic State Reportedly Seizes Last Syria-Iraq Border Crossing
The checkpoint at al-Tanf, known as al-Waleed in Iraq, has been seized, according to a British-based monitoring group that says ISIS fighters now control half of Syria.
An Irreplaceable Replacement, This Sub Gets The Job Done
Josephine Brewington, from Indiana, is the 2015 Substitute Teacher of the Year.
How Do You Motivate Kids To Stop Skipping School?
A study in an Indian slum tried promising a reward: Improve your attendance, and you'll get a small treat. But for third-graders, sometimes these incentive schemes can do more harm than good.
Irish Voters Decide Whether To Legalize Same-Sex Marriage
Polls show the "yes" vote is stronger in the conservative, predominately Catholic country. But public opinion surveys could be masking a "shy no vote," observers say.
In America's Heartland, Heroin Crisis Is Hitting Too Close To Home
Midwest and Southwest states struggle with an influx of heroin being sold for cheap by Mexican cartels. In one community, a spike in heroin-related deaths has everyone on high alert.
Census Reveals Universe Of Marine Microbes At Bottom Of The Food Chain
The ocean's tiniest inhabitants — including bacteria, plankton, krill — are food for most everything that swims or floats. Now, scientists have completed a count of this vast and diverse hidden world.
Korean Air 'Nut Rage' Executive Freed From Jail
An appeals court reduced the sentence of former Korean Air executive Heather Cho. She demanded a plane return to the gate because her macadamia nuts weren't served in a manner to her liking.
Uneasy Rider: The Origins Of Motorcycle Gangs And How They Remain A Force
Steve Cook, who heads the Midwest Outlaw Motorcycle Gang Investigators Association, tells NPR that soldiers returning from World War II formed biker gangs, which became infamous during a 1947 riot.
Adios, Trans Fats: FDA Poised To Phase Out Artery-Clogging Fat
Any day now, the FDA could announce a final rule aimed at removing much of the remaining trans fats out of the food supply. It could amount to a near ban on the fats, which wreak cardiovascular havoc.
Millions Of Dollars In Speech Fees Support Clinton Foundation
Bill, Hillary and Chelsea Clinton charge hundreds of thousands of dollars to talk to banks, universities and other groups, and give the proceeds to the family's philanthropic foundation.
Grand Jury Indicts 6 Baltimore Officers In Freddie Gray's Death
Prosecutor Marilyn J. Mosby said at a news conference that the officers will be arraigned July 2. The charges against them are mostly similar to those announced May 1.
Maryland Joins States That Won't Test New Drivers For Parallel Parking
Officials say the skills are tested by other tasks, like turning a car around. As of yet, using backup cameras on a driving test isn't allowed.
#MotorCityDrive: Is Detroit's Economic Engine Roaring Back To Life?
Michel Martin heads to Detroit for a live conversation with some of the creative forces fueling the Motor City's economy. She'll ask: What's driving Detroit's future now?
China Kicks Off 'Great Leap Forward' On The Soccer Field
China is rolling out an ambitious soccer program. President Xi Jinping is reported to be a super fan who wants China to win a World Cup. Critics say there's too much emphasis on quick results.
Chew On This: The Science Of Great NYC Bagels (It's Not The Water)
Popular myth has long credited New York's soft water for the city's irresistibly crusty, chewy bagels. But the chemistry behind a superior bagel is more complicated.
White House Ban On Militarized Gear For Police May Mean Little
An NPR analysis of equipment given to police agencies by the Pentagon since 2006 — 84,258 assault rifles, 951 armored vehicles, for example — found a vast majority of it would fall outside the ban.
Head Of Boy Scouts Says Group's Ban On Gay Adults 'Unsustainable'
Robert Gates, a former CIA director and former defense secretary, told the organization, "We must deal with the world as it is, not as we might wish it to be."
A Toilet In Every Home: Zambians Celebrate Sanitation Milestone
The practice of defecating in the open is all too common in Zambia because many families don't have other options. But now the country has achieved a milestone: its first zone free of open defecation.


text:
Media Round-up
Media Round-up is a daily collation of news and opinion relevant to secularism. Links may be provided to articles peripheral to secularism when we think they are likely to be of particular interest to secularists. Links are provided to external websites for information and in the interests of free exchange. We do not accept any responsibility for the content of those sites, nor does a link indicate approval or imply endorsement of those sites.
Fri, 10 Apr 2015
Texas businesses warn of 'Indiana-like backlash' if state introduces similar religious freedom law
Christian Today, 10 April 2015
Thu, 09 Apr 2015
Hardline Islamic group is radicalising Rochdale youths, Muslim academic claims
Manchester Evening News, 9 April 2015
Nazir Afzal: 'Young people are easily led. Our anti-radicalisation schemes need to be cleverer'
Guardian, 9 April 2015
Expert reveals how ISIS groom British teenagers into joining terrorist group
Mirror, 9 April 2015
BBC's 'Britain's Jihadi Brides' told the story of an appalling phenomenon
Telegraph, 9 April 2015
Dzhokhar Tsarnaev: Boston Marathon bomber found guilty
BBC, 9 April 2015
Ultra-Orthodox school failed by Ofsted for spending too much time on Jewish religious studies
Ham and High, 9 April 2015
How the world's religious landscape will look in 2050: Islam will become America's second-largest religion as the percentage of atheists across the globe will fall
Daily Mail, 9 April 2015
Child porn vicar Charles Richardson committed suicide
BBC, 9 April 2015
ICC has no jurisdiction to prosecute Isis despite 'crimes of unspeakable cruelty'
Guardian, 9 April 2015
ISIS extremists publicly execute man 'for committing witchcraft'
Mirror, 9 April 2015
Isis releases over 200 Iraqi Yazidis after eight months in captivity
Guardian, 9 April
ISIS burns food donations from US intended for Syrian refugees
Christian Today, 9 April 2015
Child soldiers being used by ISIS to lead prisoners to their deaths
Christian Today, 9 April 2015
ISIS tweets reveal how the group rules its territories
New Scientist, 9 April 2015
Islamic fatwa decrees that toilet paper is halal: Directorate of Religious Affairs says wiping is acceptable
Daily Mail, 9 April 2015
Thousands of Turkish students sign petition to build Jedi Temple on university campus in response to construction of mosques on campuses across the country
Independent, 9 April 2015
Lyon after Charlie Hebdo - synagogues 'virtual fortresses'
Channel 4, 9 April 2015
The organisers of a women's conference at the University of South Dakota react to attempts to ban a screening of Honor Diaries
Index on Censorship, 9 April 2015
Most Americans side with gays in religious freedom disputes: Reuters/Ipsos poll
Reuters, 9 April 2015
Wed, 08 Apr 2015
Islam vs Liberalism: The classroom's silent culture war
Spiked, 8 April 2015
The fastest way to spread extremism is with the censor's boot
Guardian, 8 April 2015
Don't expect to hear anything about Islamic State during the election campaign
Spectator, 8 April 2015
Nigel Farage: larger mosques are 'not necessarily a great idea'
Guardian, 8 April 2015
Brother of UK's youngest convicted terrorist feared to have joined Isis
Guardian, 8 April 2015
A Syrian preacher at a fundamentalist mosque was shot dead in broad daylight on a London street yesterday in a suspected assassination by his country's regime
Daily Mail, 8 April 2015
Two boys aged 17 'travel to Syria from Dewsbury'
Telegraph, 8 April 2015
Dozens of historical Church of England child abuse allegations made
ITV, 8 April 2015
Former Church of England priest charged with historic sex offences against underage boy in Portslade
Argus, 8 April 2015
'The sea of forgetting': Survivor speaks of Church of England abuse
ITV, 8 April 2015
Petition launched against new CofE school in Greenwich
Wharf, 8 April 2015
Campaigners: secretive Female Genital Mutilation is hindering prosecutions
Evening Times, 8 April 2015
'Britain in danger of being outflanked by growing Islamic population' says church leader
Express, 8 April 2015
An Afghan nightmare: Forced to marry your rapist
CNN, 8 April 2015
Muslim faqir puts knife into his eye during religious procession
Metro, 8 April 2015
Pregnant Jehovah's Witness and her baby die after she refuses blood transfusions
Mirror, 8 April 2015
Civil rights come before religious freedom for secular businesses
Spiked, 8 April 2015
France: Scrap the six Christian holidays
Connexion France, 8 April 2015
Russian blasphemy row over Wagner opera ban in Siberia
BBC, 8 April 2015
Stereotypes about religious people a major turn-off in the dating game, say psychologists
Telegraph, 8 April 2015
Tue, 07 Apr 2015
'Let children discuss extremism in schools,' say teachers
Telegraph, 7 April 2015
Terror curbs leave Muslim pupils fearing arrest if they speak out, claim teachers
Times (£), 7 April 2015
Union fears teachers expected to spy on pupils as part of war on terror
Mirror, 7 April 2015
Trojan Horse-linked teachers and staff 'could face lifetime classroom ban'
Birmingham Mail, 7 April 2015
Islamic radicalisation in England's prisons 'getting worse'
BBC, 7 April 2015
Jihadi bride's dad who blamed police admits taking daughter to fiery Islamic rallies
Express, 7 April 2015
ISIS: Two more teens feared to have fled UK to join terror group in Syria
Mirror, 7 April 2015
Isis accused of beheading captives in Palestinian refugee camp Yarmouk as advance towards Syrian capital Damascus continues
Independent, 7 April 2015
UN warns situation in Damascus refugee camp is 'beyond inhumane'
Guardian, 7 April 2015
Minister welcomes calls for church to end faith selection
Bolton News, 7 April 2015


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The views expressed in articles on this channel do not necessarily reflect the views of AAAHC.
The views expressed in articles on this channel do not necessarily reflect the views of AAAHC.
Joint Commission Grants Mayo Clinic Health System in St. James Gold Seal of Approval
The hospital recently underwent an unannounced site survey and met The Joint Commission's standards for patient safety and quality control. The hospital was granted accreditation and commended on its ability to elevate standards of care.
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text:
"Watch an excerpt of the Pulitzer Prize and MacArthur "Genius" grant winner's keynote address at Colorlines.com's Facing Race 2012 conference.
It's hard to judge who's been clamoring for this more: folks who weren't at our conference and missed it, or folks who were and who want to see it again. Here's an excerpt from author the keynote address of Junot Díaz, recipient of the Pulitzer Prize and the MacArthur Foundation 'Genius' Grant, at our Facing Race 2012 conference in Baltimore last month.
This excerpt is the first 25 minutes of his talk, and there's plenty to chew on. Here, for instance, is Díaz explaining his work's recurring theme of "decolonial love":
"The funny thing about our privilege is that we all have a blind spot around our privilege, shaped exactly like us. Most of us will identify privileges that we know we could live without. So when it comes time to talk about our privileges, we'll throw shit down like it's an ace. And that shit is a three! I understand that. You grow up and you live a life where you feel like you haven't had shit, the last thing you want to give up is the one thing, the couple of things that you've really held on to."


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Airplane debris that washed ashore on an island near Madagascar could be the first tangible evidence that investigators were on the right track in their search for Malaysia Airlines Flight 370. 80
LinkedIn reported a surprise increase in profit, a sign that the professional network is seeing success as it shifts strategies.
Google is quietly distributing a new version of its Glass wearable computer aimed at businesses in industries such as healthcare, manufacturing and energy, according to people familiar with the situation.
The U.S. economy accelerated modestly in the second quarter—up 2.3%—after a slow start to 2015, but growth this year is still below the overall pace of the recovery. 286
Anyone trading Chinese shares shouldn't take a long lunch. That is the lesson from the Shanghai market's behavior in recent days, as margin calls and moves linked to government buying shake up trading.
A former University of Cincinnati police officer charged with murder in the shooting death of a black motorist has entered a plea of not guilty. 262
Both presidential candidates will address the National Urban League on Friday as part of their efforts to win over African-Americans, who turned out in record numbers to elect President Barack Obama. 82
Shell reported a sharp fall in second-quarter profit and said it would cut 6,500 jobs, amid low oil prices.
The biotechnology company raised its 2015 guidance after reporting that its second-quarter earnings rose 6.9% on better-than-expected sales growth and lower operating expenses.
Boeing assigned its aircraft-development chief to right its troubled aerial refueling tanker project, on the heels of a surprise $835 million charge to earnings.
Almost 90% of the beer made in America now is made by foreign-owned companies—and the U.S. tax code is one of the big reasons, according to congressional testimony by the founder of the Boston Beer Co.
A month after reaching a $2.5 billion settlement over interest rate rigging, Deutsche Bank told regulators its disclosures may have been incomplete because it accidentally failed to archive electronic chats involving its employees.
SoulCycle, the New York-based company that has generated a craze over its spin classes, has filed to go public.
Ukraine and a group of its bondholders moved closer to deal over $19 billion in debt after creditors agreed to take a small reduction in the face value of their holdings.
Bets are rising that China's currency is headed lower with its stock market, a signal of waning investor confidence in the country's ability to manage its economic slowdown and market turmoil.
When intellectual titans William F. Buckley and Gore Vidal debated in 1968 they changed the media landscape forever.
The Taliban appointed its acting head as their new leader, a Pakistani official and people close to the insurgent group said Thursday, as they confirmed the death of their founder, Mullah Mohammad Omar.
The latest humanitarian cease-fire in Yemen is in tatters, with violence escalating once again and little prospect of an imminent political solution.
A new wave of designer boathouses feature bars, entertaining spaces and plenty of room for play.
Two chimpanzees at a state university on Long Island shouldn't be considered people under the law, nor given rights bestowed by so-called personhood, a court finds. 67
A federal judge set a November trial date for New York state Sen. Dean Skelos and his son after the two pleaded not guilty on Thursday to new bribery and extortion charges.
Why tour Botswana in a 4x4 when paddling a canoe or kayak can get you nose to nose with nature. One writer lives to tell the tale.
Tom Cruise makes good movies. He has for years. His work speaks for itself.