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Thursday June 19, 2014
Florida Women Win 2013-14 Capital One Cup
Gainesville, Fla.
The Florida women's program won its first Capital One Cup in 2013-14.
Two NCAA titles among a total of eight top-10 finishes in the 2013-14 season gives Florida its first women's Capital One Cup.
The Gators will be formally honored as the top women's athletics program of 2013-14 at the ESPY Awards televised by ESPN on July 16, during which the Capital One Cup trophy will be presented.
Florida is the first since the Capital One Cup was introduced for the 2010-11 season to claim the award in men's and women's competition. The Gator men's program won the first two Capital One Cups in 2011 and 2012.
For each win, Capital One contributes $200,000 to UF to support student-athlete scholarships.
How Florida Won
Eight sports contributed to Florida's winning total of 152 points. Florida won NCAA team titles in gymnastics and softball.
Top four finishes by the Gator indoor (T-3rd) and outdoor (4th) track & field teams and a sixth-place finish for swimming & diving in NCAA Championships competition boosted UF's total.
The Gators also received points for placing among the top 10 in the final sport polls for lacrosse (4th), tennis (5th) and soccer (10th).
In the final standings, Florida was followed by second-place UCLA (110 points) and 2011 and 2012 Capital One Cup winner Stanford (106 points).
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They feel bad, so they found you these other deals to make up for it.
Select Local Merchants
Jimmy's RibsRead MoreSpare ribs, short ribs, baby backs — any ribs you want! Grand Rapids' Jimmy's Ribs will satisfy any meat lovers appetite. Jimmy's Ribs has a large dining room, making it easy to seat large parties. Jimmy's Ribs offers an informal dining experience for those who are allergic to jackets and ties. Love the food so much you want to serve it at your next soiree? No problem — Jimmy's Ribs offers catering. Both street parking and lot parking are available near Jimmy's Ribs. There's no need to bust your budget at Jimmy's Ribs, with affordable prices that almost always stay under $15.1309 Plainfield Ave NEGrand Rapids, MI US
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Wing HeavenRead MoreVisit Grand Rapids' Wing Heaven for fresh ribs that fall off the bone, sweet corn and homemade baked beans. No need to ditch your furry friend when visiting Wing Heaven — dogs are welcome there. Your car or ours? You'll get the food either way via pickup or delivery. Parking can be a pain in the neck, but it's as available as ever near the restaurant.3648 Division Ave SGrand Rapids, MI US
Dallas DeliRead MoreLocated in Wyoming, Dallas Deli is a popular deli that features superb sandwiches and good steak. This restaurant delivers an unforgettable dining experience set in a laid-back vibe. It's an ideal choice for guests seeking delicious food. Thanks to its outdoor seating, the restaurant is a fantastic option when the Great Lakes weather is nice. No specific attire is required, so feel free to dress casually and comfortably. Also, though the prices are considered to be lower than average, you aren't going to sacrifice any quality. In fact, you should be able to enjoy a good meal for $11 or $12, and can probably get in and out for $8 if you try. In addition to its quick service (take-out is available), the restaurant also offers delivery, and can even cater an event for you. Specializing in both lunch and dinner, a trip to Dallas Deli is definitely worthwhile. Don't worry about trying to find a spot on the street, as visitors to the restaurant do have access to a private parking lot nearby. Should you prefer to pedal over there, bicycle parking's also provided.3660 Byron Center Ave SWWyoming, MI US

subset: commoncrawl


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Austin, TXUSA
October 26, 2013
9 years.
For the last nine years, I have worked in leadership positions across the entire web technology lifecycle, including user experience direction, digital strategy and agile project management for web, interactive and mobile devices. My design focus has been SaaS web platforms, specifically CMS, CRM, social media marketing tools, social engagement tools, web analytics dashboards and content publishing applications. My work includes the following activities and roles: • user experience design leadership for SaaS products, web properties and digital brands • lean product/customer development • interaction and interface design for web applications and platforms • product management and scrum for technologies built in Python, Ruby On Rails, and PhP • Front end prototyping (HTML/CSS/Javascript) • mobile devices, responsive design, adaptive content strategy • APIs, data modeling and application development
Hi! For the last 9 years, I've been a product/UX guy from SF, CA. My focus has been in web products, SaaS platforms, content apps and converged media campaigns. Currently, I do UX at springbox.com in Austin and senior advisor/founder at subtxt.us.
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Baby Animals That Aren't Cute
Sometimes the Internet can brainwash you into thinking that every baby animal is the cutest thing you've ever seen. Get that animal on YouTube and you've got viral gold. Here's a reminder that not all baby animals are cute — some are actually pretty ugly. Ugly babies? Blasphemy!
This post was created by a member of BuzzFeed Community, where anyone can post awesome lists and creations. Learn more or post your buzz!
Preview Your Response
Here Are The Top Stories
- Dylann Roof pleaded not guilty to federal hate crime charges in the Charleston church massacre.
- The World Health Organization says that an interim analysis of a potential Ebola vaccine shows "100% efficacy in individuals."
- Beijing won its bid to host the 2022 Winter Olympics. It's the first city to host both the summer and winter games.


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Dr. Richard S. Izewski graduated from the Wroclaw Medical Univ, Wroclaw, Poland in 1990. He works in Oak Park, IL and 2 other locations and specializes in Internal Medicine. Dr. Izewski is affiliated with Advocate Illinois Masonic Medical Center, Alexian Brothers Medical Center, Illinois Valley Community Hospital, Mercy Hospital & Medical Center, Rush Oak Park Hospital and University Of Illinois Hospital Health & Science Center.View More
Internal Medicine
Medical School: Wroclaw Medical Univ, Wroclaw, Poland; Graduated 1990
*This physician has multiple office locations. See Office Information for details.
917 S Oak Park Ave Ste B
Oak Park, IL 60304
408 Madison St Lowr A
Oak Park, IL 60302
610 S Maple Ave Ste 3440
Oak Park, IL 60304
610 S Maple Ave Ste 3900
Oak Park, IL 60304
610 S Maple Ave Ste 3440
Oak Park, IL 60304


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Columbia, MOUSA
September 11, 2013
I like all kinds of food and restaurants.
I've been in Columbia for 15 years. I like cooking and trying new foods.
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Jeffrey D. Allred, Deseret News
Gary Blake's submission to the Readers' Forum last week begs a response. His criticism of the updated feasibility study is yet another attempt by those who support anti-incorporation to draw attention away from the reality that the new city of Millcreek will be financially stable.
The first feasibility study, although well intentioned, was necessarily based on assumptions about the future. The three years forming those assumptions were the worst financially since the great depression. The reality is, during the Great Recession, Millcreek still generated enough revenue to be sustainable.
The update to the feasibility study took those same projections and applied the actual growth numbers produced by the Tax Commission for the same time period to the future city of Millcreek. The actual growth was 5 times that projected by the original study. Mr. Blake attempts to scare the citizens by claiming that the study is somehow tainted by the proponents' payment. We chose to sacrifice our own money not to "buy the study results we needed," but to get the information to the citizens of Millcreek without requiring further expense to the tax payers.
As you vote this Tuesday, please vote based on the facts, not personal attacks and innuendo.
Mary Ann Strong
Salt Lake City
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Hotel Paradis
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La Joliette, Marseille, France
... our first sailing with Seaborn. This we did and it was a happy occasion for all. Special hor doevres, pink champagne and a time to meet other passengers. Of course we chatted to quite a number. It was fun :) Dinner again and then up on the top deck to watch the ship leaving port in the glow of evening! Next on to a 'show' in the 'Grand Salon' with a great vocalist - Toni Warne- a finalist on BBC's The Voice UK. Another most memorable day- ...
Saturday- market day and a party!
... had enough room to store cold beverages. Jan was in charge of purchasing beverages so she set out for the Monoprix (where they sell everything) and I set out to the farmer's market to see what we could do for hors d'oeuvres. We were figuring on about 6-8 people.
I bought some veggies for crudite here
I bought some olives here ...
Return to fabulous France
Off again on the bus and so began around a 1.5hr drive until we reached the France border. We stopped here for a toilet break and were surprised to see around 10 police vehicles, some officers with machine guns and holding road spikes so obviously they were expecting someone of interest crossing the border!?
We continued on and took a slight detour to the holiday seaside of Collioure. I loved this little village. It was very picturesque and had a ...
My First Trip to France
... the Basilique de Notre Dame de la Garde, both to see the pretty church up close as well as enjoy the fantastic view of the city and see the famous Chateau d'If, made famous by Dumas in The Count of Monte Cristo (the eponymous film having been shot in Malta, using the Santa Marija tower in Comino in the French tower's stead).
It was then time to meet my couch-surfing host, a cool guy from Bretagne called Lo�c, who I hit it off with immediately on account of the ...
... directed us straight there. Problem was that it guided us into a tunnel where, tradition has it, the GPS signal was somewhat weak (non existent) and we got lost. We were successful in the end and it was worth the trouble. The views across Marseille, the harbor and the Ile d'If were breathtaking. The main basilica inside is beautiful, too. There were paintings of sea disasters, the walls were ornamental and a big statue of St Mary ...


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افلام سكس مصري We will continue to assist scholars and teachers, students and critics - all citizens - to know more about this medium and therefore, to understand and use it well as part of their personal and social experience.
Such episodes can be nearly daily occurrences in soap operas and are frequently used in season finales of many prime time shows. افلام سكس مصري The storyboard and soundtrack are amended if necessary, and a new animatic may be created and reviewed with the director until the storyboard is perfected. Since the 1980s, there are many series that feature progressive change to the plot, the characters, or both.
It is, however, distinct from shonen-ai literally, boy-love, in which two males merely express romantic feelings for each other without actually having sexual relations. افلام نيك امهات قديم Check out Death Note, Naoki Urasawas Monster, Nodame Cantabile, and Cantarella, all titles that are not popular with bloggers, and you wont see an oversized pupil in the bunch. Then it�s battle on! What�s this? I thought soul society mentioned they weren�t going to send anyone? I guess old Yamamoto has a soft spot for em� after all! Along with Kenpachi, Unohana, Byakuya, and Kurotsuchi shows up. افلام ممنوعة من العرض سوريه Shojo-ai girl love is not a western term for the female equivalent of shonen-ai; in Japan these works are not also called yuri. افلام ممنوعة من العرض سوريه Examples of episodes include the founding of Wilmington, Delaware in Charles Reades The Disinherited Heir and the individual events comprising the picaresque novels and medieval romances. an anthology. افلام نيك امهات قديم , non-Japanese manga that includes an excellent example of the manga storytelling style.
To define episodes of care that include hospitalizations, including the time frames for pre and post-hospital care, and the types of health care.


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Porsche Holding
Volkswagen starts sales of black-box recorder for vehicle data
Jan. 14, 2015 18:18 CET
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Porsche SE cash gives Inrix fuel to grow
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Fiesta Inn Ecatepec
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The Ballet Folklorico
... musical accompaniment and the mariachi were usually visible at the side of the stage (and sometimes involved in the action.) Everything was big, loud, and colourful. Dancers in fantastic costumes performed romantic dances in large groups. There was also the odd exclusively musical number including some solos during which the musicians demonstrated just how good they were. The sound of the guitarrón solo rumbling around the auditorium was quite unique. ...
Mexico City, Day 7
... our fault buddy!". Anyway, all was well in the end.
We arrived at the apartment, met with the host who has the cutest pomeranian dog ever, and visited the place. It is gorgeous, in a nice, safe area, and very cozy. We made pans to move in the next day.
We left the apartment at around 10pm and heard there was a comedy show going on not too far away. We asked our host on tips to take a cab (to avoid a repeat of the bad experience ...
... tree above. Bizarrely we also spot the founder of London-based Mexican restaurant Wahaca, Thomasina Miers, she must be doing some research! The next day we are still struggling with the new time zone so decide to stay in the centre and see more or Mexico's many museums. The Museo del Estanquillo houses the collection of writer Carlos Monsivais and included lots of beautiful comics and illustrations. We heard the main ...
Vamos Mexico! A week in Mexico City
... left were passages so that the tourists can continue to explore the church. In the middle is a massive pan pipe organ. Then as you move forward a more elaborate mass area then finally statues of saints and Mary.
Afterwards we move to the zocalo. There are protests that run here all the time and it seems like they are scheduled. In the morning a part of the road was blocked out by people wearing red shirts, in the afternoon a protest about animals in the circus and late ...
Ahh Mehico...
... and finally find an electronics store so we can buy a power adaptor. Then we get some late lunch (Mario had the pork burrito and I had nachos - disappointed) but on the upside we were served two very icy 500ml beers in a sweet, sweet yard glass. This is how we shall always drink beers from now on. We probably won't though. They would be a hassle to wash up and probably wouldn't be practical for a dishwasher... We passed like, ten places which were selling these ...


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I have not reserved any places as no one would commit to going. Admission on the gate is £6.50, but in the past they have let us show the cars and pay the reduced entrance fee. I will be in the Grapes Car park in Wrea Green at 9:00am for convoy over if anyone wants to join me.
The weather forecast is dry until 19:00 hrs


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Small double hutch from rabbit shack
Small double hutch lift up roof. All doors open. Ramp is starting to come away and our rabbit started nibbling on the ramp shown in photos. It needs a good clean and could do with a freshen up of exterior weatherproofing. The roof felt was never very


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By Junno Arocho
9/16/2012 (2 years ago)
Zenit News Agency (www.zenit.org)
Speaking on the theme of "Let Religious Freedom Ring", Cardinal Dolan noted that "freedom of religion has been the driving force of almost every enlightened, un-shackling, noble cause in American history. Thus, the defense of religious freedom is not some evangelical Christian polemic, or wiley strategy of discredited Catholic bishops, but the quintessential American cause, the first line in the defense of and protection of human rights," he said.
By Junno Arocho
Zenit News Agency (www.zenit.org)
9/16/2012 (2 years ago)
Published in U.S.
Keywords: Cardianl Dolan, Religious Liberty, Religious Freedom, HHS Mandate, Free Exercise, First Amendment
WASHINGTON, D.C. (Zenit.org) - On Monday, Cardinal Timothy Dolan, Archbishop of New York and President of the United States Conference of Catholic Bishops (USCCB) delivered the Fall Lecture for the The John Carroll Society, an organization within the Archdiocese of Washington, D.C., that "promotes the enhancement of spiritual, intellectual and social fellowship among its members."
Speaking on the theme of "Let Religious Freedom Ring", Cardinal Dolan noted that "freedom of religion has been the driving force of almost every enlightened, un-shackling, noble cause in American history."
"Thus, the defense of religious freedom is not some evangelical Christian polemic, or wiley strategy of discredited Catholic bishops, but the quintessential American cause, the first line in the defense of and protection of human rights," he said.
The archbishop of New York went on to discuss various events of American history that underlined the value of religious freedom. He cited each event as "exhibits" in his case to prove that "religious freedom in American history has hardly been the cause of chilling, repressive, retrograde movements, but of the most liberating, ennobling ones."
Drawing upon examples of heroism on the part of religious leaders during the American Revolution, as well as, several notable abolitionists whose stance against slavery came from a conscience formed by faith, Cardinal Dolan went onto explain how the religious convictions of notable persons within history supported, and directly caused progressive changes within the United States.
Citing historical scholar Dan McKanan, the cardinal explained that as a result of women's role during the abolitionist movement, "the slow-but-steady advancement of women's equality, was also a religiously animated reform movement."
"This is good reminder, since, today, those who criticize the churches' mobilization in defense of religious freedom often slyly muddy it with 'war on women' slogans," he said.
Other historical events the cardinal said were influenced by religious freedom were the Reform Movement of the 19th century, the Civil Rights Movement, and the Peace Movement of the '60s.
Cardinal Dolan went on to speak of the HHS mandate as a direct threat to religious freedom. The Health and Human Services (HHS) federal mandate in question would require employers of religious institutions to pay for insurance that provides abortion-inducing drugs, contraception, and sterilization procedures to employees.
"Thus, to say it again, the wide ecumenical and inter-religious outrage over the HHS mandate is not about its coverage of chemical contraceptives and abortion-inducing drugs -- in spite of the well-oiled mantra from our opponents -- but upon the raw presumption of a bureau of the federal government to define a church's minister, ministry, message, and meaning," he said.
The president of the USCCB also had strong words for Democratic minority leader, Nancy Pelosi. The former speaker of the House, who is also Catholic, stated last year that the Catholic Church needed "to get over their conscience thing" regarding abortion and contraception.
"No, we don't; no, we can't; as believers, as Americans," he exclaimed.
Cardinal Dolan concluded his lecture, reiterating that the only freedom that the Church desires is "the freedom to carry the convictions of a faith-formed conscience into our public lives."
The Rosary
By Kevin J. Jones, CNA/EWTN News
The Boy Scouts of America is moving to change its leadership standards in order to allow openly homosexual adult leaders and volunteers. While the organization promises that individual church-affiliated councils can choose their own leaders, at least one critic ... continue reading
By Abigail James (NEWS CONSORTIUM)
First there was a video revealing Planned Parenthood Federation of America's Senior Director of Medical Services, Dr. Deborah Nucatola casually discussing selling aborted baby organs over lunch, and admitting to using partial-birth abortions to get her hands on intact ... continue reading
By Linky C. (NEWS CONSORTIUM)
Planned Parenthood's website was hacked by a group of hackers who managed to gain access into Planned Parenthood and acquire the site's databases, including the names and email addresses of employees. These details were released by the hackers to the public. MUNTINLUPA ... continue reading
By Atarah Haely (NEWS CONSORTIUM)
Under the windshield wiper of a car, owned by an unidentified serviceman, was a note warning the military of a revenge under investigation. Authorities believe the car was targeted because of the license plate identified the owner is a part of the military service. ... continue reading
By Nikky Andres (NEWS CONSORTIUM)
A Missouri sheriff made the decision to adorn all of his station's police patrol cars with the words, "In God We Trust." It has quickly sparked up a major debate and inevitably, atheist activists are quite frustrated about it. MUNTINLUPA, PHILIPPINES -The Missouri ... continue reading
By Keith A Fournier
Dana Milbank was wrong in insinuating that Rick Santorum's use of the third person in referring to his campaign was akin to a - royal we. To the contrary, it reveals the heart of a humble man who deeply cares about others. Humility is such a rare quality these days ... continue reading
By Matt C. Abbott
Granted, the Church's infallible teaching on the intrinsic immorality of contraception is derided by the libertine left, and too few Catholics assent to it. (At least some of the blame for this sad reality falls on weak and dissident clergy, but that's a subject ... continue reading
By Ken Blackwell
In two startling videos, we have seen Planned Parenthood leaders engaged in a ghoulish traffic in the organs of unborn children whom they have killed. My colleague at Family Research Council, Tony Perkins, discussed this horror on his recent radio show in an ... continue reading
By Talia Ramos (NEWS CONSORTIUM)
A man was found dead and decomposing inside his car, parked in a neighborhood in Southern California last Friday. Apparently, he had already been dead for two weeks when he was discovered. MUNTINLUPA, PHILIPPINES (Catholic Online) - CBS Sacramento Local reported that ... continue reading
By Nikky Andres (NEWS CONSORTIUM)
A 68-year-old man has drugged a young girl, sexually assaulted her with sharp objects and sucked fat from her stomach to inject into her breasts over a devastating span of six years. MUNTINLUPA, PHILIPPINES (Catholic Online) - According to the police, Louis Romano ... continue reading


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home > digestive disorders center > digestive disorders a-z list > abdominal pain in adults article > abdominal pain in adults topic guide
Abdominal Pain in Adults Topic Guide
Abdominal Pain (Adults): Abdominal pain in adults can range from a mild stomach ache to severe pain. Examples of causes of abdominal pain in adults include appendicitis, gallbladder disease, gastric ulcers, shingles, spider bites, and more. Information about when to seek medical care for abdominal pain is also included.
Must Read Articles:
Crohn's Disease Crohn's disease (Crohn disease) is an inflammatory bowel disease (IBD), and is a chronic long-term inflammation of the digestive tract. The cause of Crohn's disease is unknown. Symptoms of Crohn's disease include diarrhea, constipation, abdominal pain, rectal bleeding, bloating, and infections of the urinary tract and vagina. Treatment for Crohn's disease includes lifestyle changes in diet, medication, and surgery.
Expert Views and News


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Mini Me scoots into town
For someone nicknamed Mini-Me, Verne Troyer has a big heart. The Austin Powers star, 41, cruised into the Best Buddies Gala on Watson Island Friday night to lend his support to the cause, helping people with intellectual and developmental disabilities.
Among the attendees: founder Anthony K. Shriver; his niece, Katherine Schwarzenegger, who appeared at the Miami International Book Fair Sunday with her new book, Rock Your Body; actor George Hamilton; and photographer Bruce Weber. But all eyes were on Troyer, riding around on his souped-up scooter. He was obviously enjoying the attention.
"People always scream out, Hey, Mini-Me!'' said the Michigan native who has a rare type of skeletal dwarfism. "It's cute." So you don't want to be known for your turn on The Surreal Life?
''Nope," says the pint sized actor. "That was a low point for me. Next up: the horror movie Judge Ice. "I don't know if I play an angel or a devil yet, but they're both fun."
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[9] http://www.miami.com/local-chef-appearing-nbc-show-article
[10] http://www.miami.com/real-housewives-oc-star-miami-article
[11] http://www.miami.com/fifth-harmony-has-miami-connection-article
[12] http://www.miami.com/vape-shops-popping-everywhere-article
[13] http://www.miami.com/watch-model-charlotte-mckinney-enjoy-miami-during-swim-week-20-seconds-article
[14] http://www.miami.com/eva-mendes-personal-appearance-aventura-article
[15] http://www.miami.com/folk-night-moca-article
[16] http://www.miami.com/love-story-part-2-ryan-o039-neal-ali-mcgraw-together-again-article


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The Turlock City Council unanimously voted to ban tobacco and electronic smoking devices in parks Tuesday night, but enforcing the new resolution could prove difficult.
The Turlock Chamber of Commerce's stake in the Turlock Convention and Visitors Bureau could be coming to an end pending a vote from the Turlock City Council on Feb. 10.
Local smokers may soon find themselves at a loss for a place to light up in public as, after five months of discussion, the decision to ban smoking and electronic or vapor smoking devices will appear before the Turlock City Council on Tuesday.
Unlike most weekends, City Hall was an active site on Saturday with the inaugural Turlock City Council workshop taking place where the new mayor and council set out to discuss their strategic plan for the city.
Congressman Jeff Denham (R-Turlock) is addressing business owners' concerns with a recent increase in Americans with Disabilities Act compliance lawsuits at the national level.
Driving on a country road in foggy weather is dangerous and all the more reason to establish a road to connect Highway 99 and Interstate 5, at least according to Kendall Flint whose company Flint Strategies is in charge of public outreach for the project that will likely take between six and 12 years to complete.
A new mayor and council means new appointments to local and regional committees and Mayor Gary Soiseth will be at the helm of a majority of them, especially those pertaining to water.
Despite plans to repeal and replace the City of Turlock's Zoning Ordinance since November, it could be several months before the City Council reviews new changes as the item was referred back to the Planning Commission for a more comprehensive analysis.
After a slew of serious accidents in Turlock in recent months, the Chief of Police will address the public and the Turlock City Council on Tuesday on steps being taken to counteract the tragic incidents.
In the wake of his State of the State address, Governor Jerry Brown released his proposed 2015-2016 budget on Friday which places education at the forefront amongst other familiar issues like paying down debt and water projects.
Local business owners, truckers and frequent travelers are likely familiar with a quandary unique to Turlock and its surrounding towns: the lack of a direct connection between Highway 99 and Interstate 5.
In a meditation on his father's time as governor- as well as his own three previous terms - Governor Jerry Brown took a long look back during his state of the state address on Monday while also expressing an optimistic approach towards the future.
The New Year is a time where many plan people for change, but one thing guaranteed in store for citizens is several new laws.
The new year is fast approaching and so is the Turlock City Council's consideration of repealing the city's Zoning Ordinance in its entirety, meaning permitting requirements for uses, development standards and permitting processes in all zoning districts will be affected.
In 2014, more than 40 percent of the Stanislaus County Mental Health Board members resigned, moved or passed away.
Page 8 of 72
Monthly solid waste user fees could be increased for the first time in 12 years, following Turlock City Council's unanimous decision on Tuesday to ...
The U.S. Department of Agriculture and National Institutes of Health partnered to add the NIH Body Weight Planner to USDA's SuperTracker online tool ...
The Department of Labor is allocating millions of dollars to California to put workers forced into unemployment because of the ongoing drought back to work ...
A regional solution to the need for drinking water is one step closer to reality as the Stanislaus Regional Water Authority voted Thursday morning to ...
Residents of Hughson will soon be paying $22.81 more a month for water, after the Hughson City Council voted to move forward with a ...
There are quite a number of seats up for election in local school districts, community service districts and municipal advisory councils this November - along with ...
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- Field Yates, ESPN Insider
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Passing along details of the one-year contracts recently signed by wide receiver Michael Jenkins, cornerback Marquice Cole and linebacker Niko Koutovides:
Michael Jenkins
Terms: One year, $855,000 maximum value
Base salary: $840,000 (non-guaranteed)
Offseason workout bonus: $15,000
Cap charge: $570,000
Niko Koutovides
Terms: One year, $865,000 maximum value
Base salary: $840,000 (non-guaranteed)
Offseason workout bonus: $25,000
Cap charge: $580,000
Marquice Cole
Terms: One year, $730,000 maximum value
Base salary: $715,000 (non-guaranteed)
Offseason workout bonus: $15,000
Cap charge: $570,000
QUICK-HIT THOUGHTS: Each of these deals reflects a low-risk, low-cost investment for veterans with specified roles. Jenkins' deal further suggests what we had suspected about his signing, which is that he is viewed as a depth option at wide receiver who brings size, experience and a veteran presence. That's something the Patriots largely lack otherwise at wide receiver. Cole and Koutovides add special teams value, and Cole also was used as a depth defensive back in 2012. The cap charge for each is due to the minimum salary benefit ($555,000 plus their bonus considerations).
Pats mailbag: Ready to put lid on Deflategate
2hMike Reiss
NFL Nation TV wonders if Junior Galette is unemployable
27mPaul Gutierrez
Patriots place DL Easley (knees) on PUP list
19hMike Reiss
Contract catch-up: Jenkins, Cole & Niko


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2313Re: Output character encoding
Expand Messages
- Jun 5, 2012On 2012-06-05 05:55, Warren Young wrote:
> There are several places where you set this, not just one, and theyWith my test cases (provided) I have carefully narrowed down the
> all have to agree to guarantee correct output:
> DB -> back end -> Apache -> HTML -> Apache::ASP -> browser
> If they do not all agree, you can either get mixed encodings or
> encoding ping-ponging.
> So, you have to check all the links in that chain:
inconsistency to Apache::ASP, since everything else is either not
applicable or the same.
> - Apache has things like the "AddDefaultCharset" directive which playNo, it doesn't, since I'm not testing the browser. For the record
> into this.
though, when I use GET -e, I see the correct header in both tests:
Content-Type: text/html; charset=ISO-8859-1
> - For the Perl aspects, I recommend just reading the Perl manualPerl is behaving as documented. Apache::ASP is giving me trouble.
> chapter on it: perldoc perlunicode. Perl's Unicode support is deep,
> broad, and continually evolving[*]. You really must read your
> particular version's docs to know exactly how it's going to behave.
> There have been several breaking changes over the past decade or so.
> - There are at least three ways to set the character encoding in yourThat's all true, but none of it matters since with a mixed encoding
> HTML. RTFEE: https://en.wikipedia.org/wiki/Character_encodings_in_HTML
> - And finally, it's possible to set a browser to ignore whatever it's
> told by the HTTP server and the document, and force it to interpret
> the data using some other character set.
output, there is no character set encoding that I can use on the browser
to show a correct decoding.
>Yes, this is right out of the manual (open):
>> Regular perl/CGI output defaults to ISO-8859-1 encoding,
> Really? I'd expect it to take the overall Perl default, which is
> UTF-8 on most Unix type systems with Perl 5.6 onward on OSes
> contemporary with that version of Perl. I would have expected that
> you'd have to go out of your way to force a return to Latin-1.
"... the default layer for the operating system (:raw on Unix, :crlf on
Windows) is used."
The :utf8 output layer encoding must be explicitly set, as it is not the
default. However, I have not figured out how to do this successfully
within Apache::ASP.
> It's 2012. Please, please, please abandon Latin-1. Everything speaksThis is part of an exercise to do just that. At the moment, we have
> UTF-8 these days, at the borders at least, even systems like Windows
> and JavaScript where it isn't the native character set. It is safe to
> consider UTF-8 the standard Unicode encoding online.
many lines of legacy code still using Latin-1, and are converting them
step-wise to use UTF-8. As the test cases show however, they do not
play well together on Apache::ASP (though they are fine everywhere
else). If anyone has any suggestions on how this can be resolved so
that we can continue the conversion, that would be much appreciated.
Arnon Weinberg
To unsubscribe, e-mail: asp-unsubscribe@...
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Browse through a variety of lower and upper chest exercises designed by today's leaders in the health fitness industry. We have strength training exercises for beginner, intermediate and advanced users. These exercises will help you increase the strength and definition of your chest area. If you want more information on chest exercises or strength training of any kind, be sure to check out our Fit Facts section and Ask the Expert column. These chest exercises are also featured in full workout routines in our Workouts section.
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Patio & Outdoor
Showing results 1 – 5 of 5.
Aluminum Composite Roof, Graceful Octagonal Design, Grey-Black Powder Coated Aluminum & Steel Frame, Wind Escapement Roof, Anchoring Systems Included
Select color of canopy from dropdown menu on right.
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Twin-walled Polycarbonate Roof Panels, Powder-coated Dark Gray Aluminum and Steel Frame
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The Coat Hanger Argument & The Flaws Therein
Lately, I've been hearing a lot about coat hangers. Coat hangers and dirty back alleys. Were abortion to be restricted, they say, women will be lining up for coat hanger abortions in alleys. No, seriously, they're actually saying that.
In nearly every case, the reason a woman has an abortion is that the pregnancy was unwanted. It is not because of a pregnancy due to rape or incest or because the life of the mother is at risk.: I am talking here about abortions of convenience, because the mother does not wish to be pregnant. These account for roughly 98% of all abortions in America. With that in mind, there's something I don't get. Abortion is, as the left is giddy to tell us, a choice. Don't want to risk an unsafe abortion? Don't have one.
The argument seems to be that, as women will have abortions anyway, they should be kept legal for safety reasons. Robbery, assault, and domestic violence are some of the top crimes in America. They are all illegal, and they all happen anyway. Should they, therefore, be made legal to keep them safe? We hear stories of people defending their homes or lives from criminal activity in which the criminals end up injured. Surely breaking the law should not be so dangerous!
Honestly, the "we will just do it anyway" argument is just ridiculous. Breaking the law shouldn't be safe. If you want to keep abortion for convenience legal, please come up with a better argument. This one isn't doing you any favors.
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— Boy, the Democrats are really knocking out that "culture of corruption," aren't they? Bribery recipient William Jefferson received a


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Location: Miami, FL
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Norwegian Cruise Line - Norwegian Pearl
Miami, FL
Ubisoft ES press conference, Orpheum Theatre, Los Angeles, Calif.
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June 15, 2015 |
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Release Date:
September 9, 2008
This concert performance captures the legendary Ennio Morricone conducting the Roma Sinfonietta Orchestra through a number of his most famous film works including selections from Once Upon a Time In America, The Good, The Bad, and the Ugly, and The Mission. ~ Perry Seibert, Rovi
- Genre: Music
- Category Instrumental Music
- Run Time: 01 hr 44 min
- Language: English
- Picture Format: widescreen
- Lead Actor: Susanna Rigacci
- Director: Giovanni Morricone
other Info.
- Online Item #: 11499678
- Store Item Number (DPCI): 246-02-7788
- Made in the USA or Imported


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Woman Fucks Kid hot news Men', women' & kids' shoes footwear shoes., Free shipping, free returns. 24/7 customer care 1.888.233.6743. over 340+ of your favorite brands; shoes, sandals, boots, clogs, clothing & more. casual shoes. Woman Fucks Kid hot news Bedding & bed sets online adults, teens, kids, & baby, Shop leading brands in kid's bed sets, crib bedding, and luxury linens, all at discount online bedding prices at bedding.com.. Woman Fucks Kid hot news Printable worksheets kids & teachers | kidskonnect., Premium worksheets and study packs for kids, parents and teachers. premium and free printable worksheets, lesson plans, study guides, and teaching resources..
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Phoenix Ranked Third "Most Miserable" Pro Sports City in Country (No, Women's Basketball Doesn't Count as a Real Sport)
Phoenix-area sports teams just can't win -- even in a contest where all they would need to do to win is lose consistently.
Forbes Magazine released its list of the country's "Most Miserable Sports Cities," and despite the fact that only one Phoenix-area major sports team has won a championship in its respective sport -- ever -- Phoenix still only managed to earn runner-up honors.
According to Forbes, Phoenix is the third-most-miserable sports city in the country, and we know why: the Phoenix Coyotes, the Arizona Diamondbacks, the Arizona Cardinals, and the Phoenix Suns.
Of Phoenix's four major sports franchises, only the Diamondbacks have ever won a championship -- and that was a decade ago.
In total, Phoenix-area teams have participated in a combined 92 season. Only in 2001, when the D-Backs beat the New York Yankees in the World Series, did a championship find its way to the desert.
The Suns, which Forbes refers to as "perennial pretenders," have reached the NBA's Western Conference Championship game nine times since 1976 without ever winning an NBA title.
Other miserable sports cities include Seattle, which took the number-one spot, Atlanta, which took the silver medal, and Buffalo, New York, which came in fourth, much thanks to the Buffalo Bills (with the help of Scott Norwood...the Ray Finkle of real life) losing four Super Bowls in a row in the early 1990s.
We realize women's basketball's only kind of a sport, but had it been included in the rankings, the number of championships won by Phoenix-area sports teams would have tripled to three -- the Phoenix Mercury won two championships, one in 2007 and one in 2009.
There you have it, Phoenicians -- your women's basketball team is the pride of Phoenix's sporting world (insert Nelson Muntz "ha-ha" here).
See the entire Forbes list here.
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Out of Africa...part II
... so I think she may have been bored.
After immigration, I went and dropped my stuff at the Virgin Clubhouse and then made my way to the VAT refund office. All the agents were reading the paper and talking to eachother, somewhat ignoring the queue of tourists. They are SOOOO ******* strict. My agent tossed out three receipts for re-imbursement for various reasons. Like the receipt doesn't physically say that "Tax Invoice". I was chatting to one of ...
Return to Jo'burgh
Not quite such an early start for the return journey. We said our farewells and thanks to Burtie, Felicia and Kayleigh, they were off to work and school and we left with Denzil driving, back to Jo'burg via Midmar Dam near Howick. We had a good view of the Drakensburg mountain range and the small towns and villages between Kokstad and Midmar.
Back on the motorway, and Mac now driving,we saw signs ...
South Africa to Ethiopia & Kara Tribe Dance
... br style="font-family: Helvetica; font-size: 12px; line-height: normal;">We still have to go through normal security and luggage procedures, even though it is just the two of us on this charter flight, but eventually, we get on the van that is to take us out to the plane. The interesting twist is that there is a small local man standing next to our van, plastic bag in hand, awaiting a ride to the same plane. Having another passenger on board is news to us, and ...
Busy Bee Primary School and then fossils and caves
... also sang a very cute song about how they have friends in America (though when asked very few knew where America was!), and also a song about how Rotary has helped them that was very touching.
Then I got to show them what we had brought them – we had bought them 10 soccer balls, and each of them got a backpack with a couple folders, notebooks, a ruler, a pack of Bic pens (that got a huge gasp ...
100 Wonders of the World listed by Howard Hillman
... Art USA - visited 47. Mt. Everest China & Nepal - visited 48 Antarctic Cruise Multinational - visited 49. Temple Emerald Buddha Thailand - visited 50. Hagia Sofia Turkey - visited 51. Pompeii Italy - visited 52. Kashmir Valley India 53. Prague Old Town Czech Republic - visited 54. Golden Temple India - visited 55. Amalfi Coast & Drive Italy - visited 56. Meenakshi India 57. Chartres Cathedral France 58. Mezquita of ...


text:
- Neil Paine
It's the dawn of a new year, and roughly one-third of the 2012-13 NBA season is complete. By now we have a pretty decent idea of which teams are truly good and bad, but while NBA teams' records tend to stabilize over far fewer games than their counterparts in football and baseball, scheduling and early-season randomness can still play a role in team records, even 30 games into the season.
Cutting through the fog, a good analyst still needs to account for a team's point differential (usually a better indicator of true team strength than basic win-loss records) and the strength of opponents faced thus far, with a healthy dose of regression to the mean included for good measure. After a third of the season, even a power rating based on schedule-adjusted margin of victory needs to be regressed about 45 percent toward preseason expectations.
After taking all of that into account, we can construct a set of predictive ratings which can then be fed into a simulator for the purpose of projecting future outcomes. So which teams will ring in 2013 with a surprising January? And, conversely, which teams are primed for a disappointment? Let's go to the simulation results:
Source: Dellavedova agrees to return to Cavs
3hDave McMenamin
Celtics acquire Z. Dragic, save Heat millions
2dBrian Windhorst
Patient Celtics hoping they're another step closer
2dChris Forsberg
Sources: Cavs trade Miller, Haywood to Blazers
2dBrian Windhorst
NBA to offer single-game PPV telecasts for $6.99
7dDarren Rovell
Cuban: Jordan situation is like 'makeup sex'
7dArash Markazi
Nuggets, Lakers poised for a run
1/2/2013 - NBA Boston Celtics Denver Nuggets Golden State Warriors Los Angeles Lakers Milwaukee Bucks Portland Trail Blazers Utah Jazz + more


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Most Cited Cancer Letters Articles
The most cited articles published since 2010, extracted from Scopus.
Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
Volume 307, Issue 1, August 2011, Pages 26-36
Bin Bao | Zhiwei Wang | Shadan Ali | Dejuan Kong | Yiwei Li | Aamir Ahmad | Sanjeev Banerjee | Asfar S. Azmi | Lucio Miele | Fazlul H. Sarkar
Activation of Notch-1 is known to be associated with the development and progression of human malignancies including pancreatic cancer. Emerging evidence suggest that the acquisition of epithelial-mesenchymal transition (EMT) phenotype and induction of cancer stem cell (CSC) or cancer stem-like cell phenotype are interrelated and contributes to tumor recurrence and drug resistance. The molecular mechanism(s) by which Notch-1 contributes to the acquisition of EMT phenotype and CSC self-renewal capacity has not been fully elucidated. Here we show that forced over-expression of Notch-1 leads to increased cell growth, clonogenicity, migration and invasion of AsPC-1 cells. Moreover, over-expression of Notch-1 led to the induction of EMT phenotype by activation of mesenchymal cell markers such as ZEB1, CD44, EpCAM, and Hes-1. Here we also report, for the first time, that over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. Re-expression of miR-200b led to decreased expression of ZEB1, and vimentin, and increased expression of E-cadherin. Over-expression of Notch-1 also increased the formation of pancreatospheres consistent with expression of CSC surface markers CD44 and EpCAM. Finally, we found that genistein, a known natural anti-tumor agent inhibited cell growth, clonogenicity, migration, invasion, EMT phenotype, formation of pancreatospheres and expression of CD44 and EpCAM. These results suggest that the activation of Notch-1 signaling contributes to the acquisition of EMT phenotype, which is in part mediated through the regulation of miR-200b and CSC self-renewal capacity, and these processes could be attenuated by genistein treatment. © 2011 Elsevier Ireland Ltd.
MiR-126 functions as a tumour suppressor in human gastric cancer
Volume 298, Issue 1, December 2010, Pages 50-63
Runhua Feng | Runhua Feng | Runhua Feng | Xuehua Chen | Xuehua Chen | Yingyan Yu | Yingyan Yu | Liping Su | Liping Su | Beiqin Yu | Beiqin Yu | Jianfang Li | Jianfang Li | Qu Cai | Qu Cai | Min Yan | Min Yan | Min Yan | Bingya Liu | Bingya Liu | Zhenggang Zhu | Zhenggang Zhu | Zhenggang Zhu
MicroRNAs have emerged as important gene regulators and are recognised as key players in carcinogenesis. In the present study, we show that miR-126 was significantly down-regulated in gastric cancer tissues compared with matched normal tissues and was associated with clinicopathological features, including tumour size, lymph node metastasis, local invasion and tumour-node-metastasis (TNM) stage. Ectopic expression of miR-126 in SGC-7901 gastric cancer cells potently inhibited cell growth by inducing cell cycle arrest in G0/G1 phase, migration and invasion in vitro as well as tumorigenicity and metastasis in vivo. Mechanistically, we identified the adaptor protein Crk as a target of miR-126. Taken together, our results suggest that miR-126 may function as a tumour suppressor in gastric cancer, with Crk as a direct target. © 2010 Elsevier Ireland Ltd.
Anti-angiogenesis therapy in cancer: Current challenges and future perspectives
Volume 320, Issue 2, July 2012, Pages 130-137
Farbod Shojaei
It has been nearly 9. years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical investigations have identified major drawbacks associated with the application of this class of agents, including inherent/acquired resistance and induction of tumor invasiveness. In addition, lack of thoroughly validated predictive biomarkers has been one of the major hurdles to stratify cancer patients and to monitor tumor progression and response to the therapy. Investigations in clinic and preclinical models have provided some molecular and cellular mechanisms for the above challenges. This review aims to provide a concise update from recent findings. © 2012 Elsevier Ireland Ltd.
Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer
Volume 288, Issue 1, February 2010, Pages 99-106
Panayiotis A. Theodoropoulos | Hara Polioudaki | Sofia Agelaki | Sofia Agelaki | Galatea Kallergi | Zacharenia Saridaki | Zacharenia Saridaki | Dimitris Mavroudis | Dimitris Mavroudis | Vassilis Georgoulias | Vassilis Georgoulias
The CD44+/CD24-/low and ALDH1+ cell phenotypes are associated with stemness and enhanced tumorigenic potential in breast cancer. We assessed the expression of CD44, CD24 and ALDH1 on tumor cells circulating in the peripheral blood (CTCs) of patients with metastatic breast cancer using triple-marker immunofluorescence microscopy. Among a total of 1439 CTCs identified in 20 (66.7%) out of 30 patients, 35.2% had the stem-like/tumorigenic phenotype CD44+/CD24-/low, whereas 17.7% of the CTCs analyzed in seven patients, were ALDH1high/CD24-/low. In conclusion, we report the existence of a subpopulation of CTCs with putative stem cell progenitor phenotypes in patients with metastatic breast cancer. © 2009 Elsevier Ireland Ltd. All rights reserved.
DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis
Volume 332, Issue 2, May 2013, Pages 237-248
Wynand P. Roos | Bernd Kaina
DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these agents induce a plethora of different DNA lesions, it is firstly important to identify the specific lesions responsible for initiating apoptosis before the apoptotic executing pathways can be elucidated. Here, we describe specific DNA lesions that have been identified as apoptosis triggers, their repair and the signaling provoked by them. We discuss methylating agents such as temozolomide, ionizing radiation and cisplatin, all of them are important in cancer therapy. We show that the potentially lethal events for the cell are O6-methylguanine adducts that are converted by mismatch repair into DNA double-strand breaks (DSBs), non-repaired N-methylpurines and abasic sites as well as bulky adducts that block DNA replication leading to DSBs that are also directly induced following ionizing radiation. Transcriptional inhibition may also contribute to apoptosis. Cells are equipped with sensors that detect DNA damage and relay the signal via kinases to executors, who on their turn evoke a process that inhibits cell cycle progression and provokes DNA repair or, if this fails, activate the receptor and/or mitochondrial apoptotic cascade. The main DNA damage recognition factors MRN and the PI3 kinases ATM, ATR and DNA-PK, which phosphorylate a multitude of proteins and thus induce the DNA damage response (DDR), will be discussed as well as the downstream players p53, NF-κB, Akt and survivin. We review data and models describing the signaling from DNA damage to the apoptosis executing machinery and discuss the complex interplay between cell survival and death. © 2012 Elsevier Ireland Ltd.
Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer
Volume 316, Issue 2, March 2012, Pages 196-203
Hanshao Liu | Hanshao Liu | Lin Zhu | Bingya Liu | Liu Yang | Xianxin Meng | Wei Zhang | Yueyun Ma | Huasheng Xiao | Huasheng Xiao
Recent studies demonstrated that in several human malignancies aberrant expression profiles of circulating microRNAs (miRNAs) anticipate great cancer diagnostic potential. Here we showed that serum miR-378 could serve as a novel noninvasive biomarker in gastric cancer (GC) detection. Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187 *, miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls. Collectively, these data support our contention that serum miR-378 has strong potential as a novel noninvasive biomarker in gastric cancer detection. © 2011 Elsevier Ireland Ltd.
Plant lectins: Potential antineoplastic drugs from bench to clinic
Volume 287, Issue 1, January 2010, Pages 1-12
Bo Liu | He jiao Bian | Jin k. Bao
Plant lectins, carbohydrate-binding proteins distributed widely in a variety of plant species, have drawn a rising attention for cancer biologists due to their remarkable anti-tumour properties. In this review, we present a brief outline of the up-to-date advances of plant lectins in elucidating their complex anti-cancer mechanisms implicated in apoptosis and autophagy. In addition, we further discuss the pre-clinical and clinical studies of plant lectins for their potential therapeutic applications. In conclusion, these inspiring findings would open a new perspective for plant lectins as potential antineoplastic drugs from bench to clinic. © 2009 Elsevier Ireland Ltd. All rights reserved.
MiR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2
Volume 298, Issue 2, December 2010, Pages 150-158
Yihui Ma | Shuangni Yu | Wugan Zhao | Zhaohui Lu | Jie Chen
MicroRNAs are short regulatory RNAs. A growing body of data implicates altered miRNA participate in the development of cancers and miR-27a is abnormally upregulated in several types of cancers identified as an oncogene. Although overexpressed in pancreatic adenocarcinoma, the oncogenic role of miR-27a has not yet been reported. In this study, we showed that inhibition of miR-27a suppressed the growth, colony formation and migration of pancreatic cancer cells. By using a reporter-screening assay, we discovered that the 3'UTR of Sprouty2 (Spry2) carried a putative miR-27a binding site. Furthermore, the Spry2 protein, which has a low expression level in pancreatic adenocarcinoma, was upregulated by transfection with a miR-27a inhibitor. The data reported here are the first to indicate that miR-27a plays an oncogenic role by targeting Spry2 and modulating the malignant, biological behavior of pancreatic cancer cells. This suggests the potential for miR-27a to be used as a target in the diagnosis and treatment of pancreatic adenocarcinoma. © 2010 Elsevier Ireland Ltd.
Focal adhesion kinase: A prominent determinant in breast cancer initiation, progression and metastasis
Volume 289, Issue 2, March 2010, Pages 127-139
Ming Luo | Jun Lin Guan | Jun Lin Guan
Focal adhesion kinase (FAK) is an intracellular non-receptor tyrosine kinase. In addition to its role as a major mediator of signal transduction by integrins, FAK also participates in signaling by a wide range of extracellular stimuli including growth factors, G-protein-coupled receptor agonists, cytokines, and other inflammatory mediators. The link between FAK and breast cancers is strongly suggested by a number of reports showing that FAK gene is amplified and overexpressed in a large fraction of breast cancer specimens. In addition, increased FAK expression and activity frequently correlate with metastatic disease and poor prognosis. Since its discovery in early 1990s, numerous studies have shown a role for FAK in the regulation of cell spreading, adhesion, migration, survival, proliferation, differentiation, and angiogenesis. Many of these studies in cultured cells provided strong evidence to connect FAK expression/activation to the promotion of cancer. Recently, a prominent role of FAK in promoting mammary tumorigenesis, progression and metastasis has been unveiled by different animal models of human breast cancer, including xenograft models in immunodeficient rodents and spontaneous tumor models in transgenic mice that have specific deletion of FAK in the mammary epithelial cells during embryonic or postnatal development. These in vivo studies established FAK as a prominent determinant in mammary cancer initiation, progression and metastasis. Furthermore, a novel function of FAK in maintaining mammary cancer stem/progenitor cells in vivo has been recently reported, which may provide a novel cellular mechanism of FAK in promoting breast cancer initiation and progression. The wealth of knowledge accumulated over almost two decades of research on FAK should help to design potentially novel therapies for breast cancer. © 2009 Elsevier Ireland Ltd. All rights reserved.
Epithelial-mesenchymal transition in ovarian cancer
Volume 291, Issue 1, May 2010, Pages 59-66
Daniele Vergara | Benjamin Merlot | Jean Philippe Lucot | Pierre Collinet | Denis Vinatier | Isabelle Fournier | Michel Salzet
Ovarian cancer is a highly metastatic disease and the leading cause of death from gynecologic malignancy. Hence, and understanding of the molecular changes associated with ovarian cancer metastasis could lead to the identification of targets for novel therapeutic interventions. The conversion of an epithelial cell to a mesenchymal cell plays a key role both in the embryonic development and cancer invasion and metastasis. Cells undergoing epithelial-mesenchymal transition (EMT) lose their epithelial morphology, reorganize their cytoskeleton and acquire a motile phenotype through the up- and down-regulation of several molecules including tight and adherent junctions proteins and mesenchymal markers. EMT is believed to be governed by signals from the neoplastic microenvironment including a variety of cytokines and growth factors. In ovarian cancer EMT is induced by transforming growth factor-β (TGF-β), epidermal growth factor (EGF), hepatocyte growth factor (HGF) and endothelin-1 (ET-1). Alterations in these cellular pathways candidate them as useful target for ovarian cancer treatment. © 2009 Elsevier Ireland Ltd.
Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells
Volume 300, Issue 2, January 2011, Pages 197-204
Yukihiro Akao | Shunsuke Noguchi | Akio Iio | Keitaro Kojima | Takeshi Takagi | Tomoki Naoe
MiR-34a was identified as one of the down-regulated micro-RNAs (miRs) in human colorectal cancer 5-fluorouracil (5-FU)-resistant DLD-1 cells compared with those in the parental DLD-1 cells. Exposure to 5-FU at 30μM activated phosphoinositide 3-kinase (PI3K)/Akt signaling markedly from 12. h up to 48. h in the 5-FU-resistant cells compared with that in the parental cells and resulted in an overt difference in growth at those times. Furthermore, the expression of miR-34a in the 5-FU-resistant cells was sustained at a low-level, whereas it was up-regulated in the parental cells after the 5-FU treatment. Sirt1, which is one of the target genes for miR-34a and related to drug-resistance, was strikingly up-regulated in the 5-FU-resistant cells. The ectopic expression of miR-34a in the 5-FU-resistant cells inhibited growth, as in the parental cells, and attenuated the resistance to 5-FU through the down-regulation of Sirt1 and E2F3. Moreover, the silencing of Sirt1 significantly canceled the resistance to 5-FU in the 5-FU-resistant cells. These findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate, at least in part, the resistance to 5-FU in human colorectal cancer DLD-1 cells. © 2010 Elsevier Ireland Ltd.
Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
Volume 303, Issue 1, April 2011, Pages 9-20
Radhamani Kannaiyan | Muthu K. Shanmugam | Gautam Sethi
Identification of active constituents and their molecular targets from traditional medicine is an enormous opportunity for modern pharmacology. Celastrol is one such compound that was originally identified from traditional Chinese medicine (Thunder of God Vine) almost three decades ago and generally used for the treatment of inflammatory and auto-immune diseases. Celastrol has attracted great interest recently, especially for its potential anti-inflammatory and anti-cancer activities. The anti-inflammatory effects of this triterpene have been demonstrated in animal models of different inflammatory diseases, including arthritis, Alzheimer's disease, asthma, and systemic lupus erythematosus. This triterpene has also been found to inhibit the proliferation of a variety of tumor cells and suppress tumor initiation, promotion and metastasis in various cancer models in vivo. Celastrol's ability to modulate the expression of pro-inflammatory cytokines, MHC II, HO-1, iNOS, NF-κB, Notch-1, AKT/mTOR, CXCR4, TRAIL receptors DR4 and DR5, CHOP, JNK, VEGF, adhesion molecules, proteasome activity, topoisomerase II, potassium channels, and heat shock response has been reported. This review describes the various molecular targets of celastrol, cellular responses to celastrol, and animal studies with celastrol in cancer and other inflammatory disorders. © 2010 Elsevier Ireland Ltd.
Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: A new protein enters the scene
Volume 288, Issue 1, February 2010, Pages 10-16
Davide Bolignano | Valentina Donato | Antonio Lacquaniti | Maria Rosaria Fazio | Caterina Bono | Giuseppe Coppolino | Michele Buemi
The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. The aim of the present review is to point out the main contradictory, sometimes even paradoxical, effects attributed to NGAL in human neoplasias. For instance, acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. Moreover, in thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. However, on the contrary, some studies have demonstrated that NGAL can inhibit the pro-neoplastic factor HIF-1α, FA-Kinase phosphorylation and also VEGF synthesis, thus suggesting that, in alternative conditions, NGAL also, paradoxically, has an anti-tumoral and anti-metastatic effect in neoplasias of, for example, the colon, ovary and pancreas. Finally, in the field of clinical oncology, attention is currently focused on the potential use of NGAL levels in making an early diagnosis, establishing a prognosis and predicting response to different treatments. © 2009 Elsevier Ireland Ltd. All rights reserved.
A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy
Volume 289, Issue 2, March 2010, Pages 151-160
Qunzhou Zhang | Shihong Shi | Yun Yen | Jimmy Brown | Joseph Quoc Ta | Anh D. Le
The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2%) of CD133+ CSCs was identified in OSCC cell lines and tissues. These CD133+ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133- counterparts. Meanwhile, CD133+ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133+ CSCs. Our data suggest that CD133+ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC. © 2009 Elsevier Ireland Ltd. All rights reserved.
NF-κB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells
Volume 295, Issue 2, September 2010, Pages 214-228
Harald J. Maier | Uta Schmidt-Straßburger | Margit A. Huber | Margit A. Huber | Eva M. Wiedemann | Hartmut Beug | Thomas Wirth
The transcription factor NF-κB is constitutively active in pancreatic adenocarcinoma. Here we explore the contribution of NF-κB to the malignant phenotype of pancreatic cancer cells in addition to its anti-apoptotic role. Block of NF-κB signalling by non-destructible IκBα rendered cells resistant to TGF-β-induced epithelial-mesenchymal transition (EMT). In contrast, NF-κB activation by TNF-α or expression of constitutively active IKK2 induced an EMT-phenotype with up-regulation of vimentin and ZEB1, and down-regulation of E-cadherin. EMT could also be induced in cells with defective TGF-β signalling. Functional assays demonstrated reduced or strongly enhanced migration and invasion upon NF-κB inhibition or activation, respectively. © 2010 Elsevier Ireland Ltd.
Targeting apoptotic and autophagic pathways for cancer therapeutics
Volume 300, Issue 2, January 2011, Pages 105-114
Jun jie Liu | Mou Lin | Jia ying Yu | Bo Liu | Jin ku Bao
Apoptosis and autophagy are genetically regulated, evolutionarily-conserved processes that regulate cell fate; however, apoptosis invariably contributes to cancer cell death, whereas autophagy plays the Janus role of cancer cell survival and death. In this review, we firstly focus on targeting cancer cells via several key apoptotic pathways for anti-cancer therapy. Additionally, we demonstrate that some autophagic pathways play dual roles in cancer, and further elucidate the intricate relationship between apoptosis and autophagy. In summary, these findings may ultimately allow biologists to harness apoptotic and autophagic pathways as novel targets for cancer therapeutics. © 2010 Elsevier Ireland Ltd.
MicroRNAs as potential biomarkers in human solid tumors
Volume 329, Issue 2, February 2013, Pages 125-136
Jun Shen | Sanford A. Stass | Feng Jiang
MicroRNAs (miRNAs) regulate the expression of approximately 30% of protein-coding genes. Functions of miRNAs are essential to maintain a steady state of cellular machinery. Dysregulations of miRNAs play pivotal roles in the initiation and progression of malignancies. Abnormal miRNA expressions have been found in a variety of human solid tumors. Furthermore, extracellular miRNAs could circulate in body fluids, and hence show great promise for refining diagnosis and prognosis of cancer. Here we review the progress of analysis of microRNAs as a potential approach for diagnosis and prognosis of solid cancer. We will also discuss obstacles in developing miRNAs as circulating biomarkers. © 2012 Elsevier Ireland Ltd.
Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells
Volume 295, Issue 1, September 2010, Pages 110-123
Yue Wang | Yue Wang | Xiu Long Niu | Ye Qu | Jian Wu | Ya Qin Zhu | Wei Jia Sun | Ling Zhi Li | Ling Zhi Li
It has been shown that IL-6 is elevated in the serum and ascites of ovarian cancer patients, and increased IL-6 concentration correlates with poor prognosis and chemoresistance. However, the role of IL-6 expression in the acquisition of the chemoresistance phenotype and the underlining mechanisms of drug resistance in ovarian cancer cells remain unclear. Here we demonstrate that both exogenous (a relatively short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce cisplatin and paclitaxel resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to anticancer drugs. IL-6-mediated resistance of ovarian cancer cells exhibits decreased proteolytic activation of caspase-3. Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance-related genes (MDR1 and GSTpi) and apoptosis inhibitory proteins (Bcl-2, Bcl-xL and XIAP), as well as activation of Ras/MEK/ERK and PI3K/Akt signaling. Therefore, modulation of IL-6 expression or its related signaling pathway may be a promising strategy of treatment for drug-resistant ovarian cancer. © 2010 Elsevier Ireland Ltd.
Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms
Volume 295, Issue 1, September 2010, Pages 7-16
William Ka Kei Wu | Joseph Jao Yiu Sung | Chung Wa Lee | Jun Yu | Chi Hin Cho | Chi Hin Cho | Chi Hin Cho
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risks for esophageal, gastric and colon cancers as well as other solid tumors. The antitumor effect of NSAIDs is mediated through cyclooxygenase-2 (COX-2)-dependent and -independent regulation of oncogenic and tumor-suppressive pathways. Recent discoveries have shed new light on the regulation of COX-2 at the molecular level in these cancers. Moreover, prostaglandin E2 (PGE2), a COX-2-derived eicosanoid, has been found to affect numerous tumorigenic processes. In this connection, PGE2 activates multiple intracellular signaling pathways, including (1) transactivation of epidermal growth factor receptor (EGFR); (2) protein kinase C-dependent, EGFR-independent activation of extracellular signal-regulated kinase (ERK) and the transcription factors activator protein-1 and c-Myc; (3) G-protein-mediated activation of β-catenin/TCF-dependent transcription. Activation of these signaling pathways by PGE2 is mediated by EP receptors whose inhibitors suppress gastrointestinal carcinogenesis. Taken together, COX-2 expression is dysregulated in many types of cancer and COX-2-derived PGE2 elicits multiple oncogenic signals to promote carcinogenesis. Targeting PGE2 signaling by EP receptor antagonists holds promise for the development of targeted therapy for the treatment of cancer. © 2010 Elsevier Ireland Ltd.
MiR-195, miR-455-3p and miR-10a* are implicated in acquired temozolomide resistance in glioblastoma multiforme cells
Volume 296, Issue 2, October 2010, Pages 241-248
Kenta Ujifuku | Kenta Ujifuku | Norisato Mitsutake | Shu Takakura | Michiko Matsuse | Vladimir Saenko | Keiji Suzuki | Kentaro Hayashi | Takayuki Matsuo | Kensaku Kamada | Izumi Nagata | Shunichi Yamashita | Shunichi Yamashita
To identify microRNAs (miRNAs) specifically involved in the acquisition of temozolomide (TMZ) resistance in glioblastoma multiforme (GBM), we first established a resistant variant, U251R cells from TMZ-sensitive GBM cell line, U251MG. We then performed a comprehensive analysis of miRNA expressions in U251R and parental cells using miRNA microarrays. miR-195, miR-455-3p and miR-10a* were the three most up-regulated miRNAs in the resistant cells. To investigate the functional role of these miRNAs in TMZ resistance, U251R cells were transfected with miRNA inhibitors consisting of DNA/LNA hybrid oligonucleotides. Suppression of miR-455-3p or miR-10a* had no effect on cell growth, but showed modest cell killing effect in the presence of TMZ. On the other hand, knockdown of miR-195 alone displayed moderate cell killing effect, and combination with TMZ strongly enhanced the effect. In addition, using in silico analysis combined with cDNA microarray experiment, we present possible mRNA targets of these miRNAs. In conclusion, our findings suggest that those miRNAs may play a role in acquired TMZ resistance and could be a novel target for recurrent GBM treatment. © 2010 Elsevier Ireland Ltd.
Tumor necrosis factor
Volume 328, Issue 2, January 2013, Pages 222-225
Wen Ming Chu
Tumor necrosis factor (TNF) is a critical cytokine, which contributes to both physiological and pathological processes. This mini-review will briefly touch the history of TNF discovery, its family members and its biological and pathological functions. Then, it will focus on new findings on the molecular mechanisms of how TNF triggers activation of the NF-κB and AP-1 pathways, which are critical for expression of pro-inflammatory cytokines, as well as the MLKL cascade, which is critical for the generation of ROS in response to TNF. Finally, this review will briefly summarize recent advances in understanding TNF-induced cell survival, apoptosis and necrosis (also called necroptosis). Understanding new findings and emerging concepts will impact future research on the molecular mechanisms of TNF signaling in immune disorders and cancer-related inflammation. © 2012 Elsevier Ireland Ltd.
Vanadium in the detection, prevention and treatment of cancer: The in vivo evidence
Volume 294, Issue 1, August 2010, Pages 1-12
Anupam Bishayee | Abhijeet Waghray | Mehool A. Patel | Mehool A. Patel | Malay Chatterjee
Vanadium, a dietary micronutrient, is yet to be established as an essential part of the human diet. Over the past century, several biological effects of vanadium, such as insulin-mimetic action as well as amelioration of hyperlipidemia and hypertension, have been discovered. This transition element is known to influence a battery of enzymatic systems, namely phosphatases, ATPases, peroxidases, ribonucleases, protein kinases and oxidoreductases. Multiple biochemical and molecular actions of vanadium have been implicated in its inhibitory effects on various tumor cells of human origin. Successful in vitro studies over the past few decades have advanced the anticancer research on vanadium into the preclinical stage. Vanadium in several animal cancer models provides protection against all stages of carcinogenesis - initiation, promotion, and progression. This review focuses on the current advances in cancer prevention and treatment as well as early detection by vanadium compounds in preclinical animal models while pointing to possible mechanisms of such diverse beneficial effects. Clinical pharmacokinetic and potential toxicity studies on vanadium are also highlighted in this review. Supporting and challenging evidence as well as future directions of vanadium research exploring the possibility of using this dietary agent for detection, prevention and treatment of human cancers are critically discussed. © 2010 Elsevier Ireland Ltd.
Kaposi sarcoma-associated herpesvirus (KSHV): Molecular biology and oncogenesis
Volume 289, Issue 2, March 2010, Pages 140-150
Kwun Wah Wen | Kwun Wah Wen | Blossom Damania | Blossom Damania
Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the γ-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lytic aspects of the viral lifecycle, putative viral oncogenes, as well as therapeutic regimens used for the treatment of KS, PEL, and MCD. © 2009 Elsevier Ireland Ltd. All rights reserved.
Molecular mechanisms underlying tumor dormancy
Volume 294, Issue 2, August 2010, Pages 139-146
Nava Almog
Evidence suggests that dormant, microscopic tumors are not only common, but are highly prevalent in otherwise healthy individuals. Due to their small size and non-invasive nature, these dormant tumors remain asymptomatic and, in most cases, undetected. With advances in diagnostic imaging and molecular biology, it is now becoming clear that such neoplasms can remain in an asymptomatic, dormant stage for considerable periods of time without expanding in size. Although a number of processes may play a role in thwarting the expansion of microscopic tumors, one critical mechanism behind tumor dormancy is the ability of the tumor population to induce angiogenesis. Although cancer can arise through multiple pathways, it is assumed that essentially most tumors begin as microscopic, non-angiogenic neoplasms which cannot expand in size until vasculature is established. It is now becoming clear that cancer does not progress through a continuous exponential growth and mass expansion. Clinical cancer is usually manifested only in late, unavoidably symptomatic stages of the disease when tumors are sufficiently large to be readily detected. While dormancy in primary tumors is best defined as the time between the carcinogenic transformation event and the onset of inexorable progressive growth, it can also occur as minimal residual or occult disease from treated tumors or as micro-metastases. The existence of dormant tumors has important implications for the early detection and treatment of cancer. Elucidating the regulatory machinery of these processes will be instrumental in identifying novel early cancer biomarkers and could provide a rationale for the development of dormancy-promoting tumor therapies. Despite the high prevalence of microscopic, dormant tumors in humans and the significant clinical implications of their early detection, this area in cancer research has, to date, been under-investigated. In this mini review observations, models and experimental approaches to study tumor dormancy are summarized. Additionally, analogies and distinctions between the concepts of " tumor dormancy" and that of the " cellular dormancy" of tumor cells, as well as between the " exit from tumor dormancy" and the " onset of the angiogenic switch" are discussed. © 2010 Elsevier Ireland Ltd.
Galectin-3 - A jack-of-all-trades in cancer
Volume 313, Issue 2, December 2011, Pages 123-128
Anna U. Newlaczyl | Lu Gang Yu
Galectin-3 is a mammalian β-galactoside-binding protein that is expressed by various types of human cells. Changes in galectin-3 expression and subcellular and intercellular localizations are commonly seen in cancer and pre-cancerous conditions. It is increasingly recognized that galectin-3 is an important regulator of a broad range of cancer cell activities and plays important roles in cancer cell growth, transformation, apoptosis, angiogenesis, adhesion, invasion and metastasis. Such a divergent influence of galectin-3 on cancer cell activities derives from its multiple inter- and sub-cellular localizations where it interacts with a range of different binding partners. This mini-review summaries the diverse influences of galectin-3 on cancer cell behaviours with particular emphasis on its role in tumorigenesis and metastasis. © 2011 Elsevier Ireland Ltd.


text:
- Nick Friedell, ESPN Staff Writer
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MIAMI -- LeBron James said it wouldn't be a surprise if he ended up guarding Nate Robinson in Game 2 of the Eastern Conference semifinals on Wednesday after Robinson scored a game-high 27 points in the Bulls' Game 1 win.
"It wouldn't be a surprise if I matched up with him," James said Tuesday. "But I'll take the challenge on (defense)."
Part of the challenge for the 6-foot-8, 250-pound James will be keeping up with the 5-9, 180-pound Robinson, but it wouldn't be the first time James has checked a Bulls point guard. After the Bulls won Game 1 of the 2011 Eastern Conference finals, James guarded Derrick Rose and the Heat won four straight.
"Nate is a scorer, man," Heat guard Dwyane Wade said. "We got to do a better job of contesting his shots, but Nate's going to score the basketball because he's going to shoot. We can't worry about that. I think there's other things that we have to worry about more than Nate. We've seen it -- when Nate gets on a roll there's not many guys in the league that can get hotter than Nate that make shots.
Bulls' Butler on Rose: We don't have any beef
12dNick Friedell
Bulls, White Sox reach deal with WLS AM 890
12dDoug Padilla
LeBron ready to step in vs. Robinson


text:
Shabazz Muhammad: Tony Parker to UCLA would be 'icing on the cake'
Apr 15, 2012, 10:02 AM EDT
During Saturday night's Jordan Brand Classic, the broadcast team shared an anecdote that illustrates the situation in which Georgia native Tony Parker finds himself.
This late in the recruiting process, he still had a list comprised of seven schools. He wants to have a traditional announcement of his decision at his school, complete with laying out a hat for each team still in the running, then choosing one and ceremoniously putting it on his head.
The problem with that is, seven schools, multiplied by close to $30 per hat, and it turns out to be an expensive ceremony. Time to cut his list.
The Sporting News is reporting that Parker has trimmed his list to five, UCLA, Kansas, Duke, Georgia, and Ohio State, and will announce his choice on Friday during a news conference at his school.
Shabazz Muhammad, who won co-MVP honors at the Jordan Brand Classic and is signed to UCLA, and Rasheed Sulaimon, a 6-3 guard signed to play at Duke in the fall, both told The Sporting News that they hope Parker chooses their program.
"I can't wait until he decides to come to UCLA hopefully. He's such a good player, and if we get him, that's the icing on the cake," said Muhammad. "It's a big time program and needs big time players."
Parker averaged 16.8 points, 11 rebounds, and three blocks per game this past season for Miller Grove (Ga.) and led the Wolverines to a 24-9 overall record.
If Parker chooses UCLA, he would join Kyle Anderson of St. Anthony (N.J.), Jordan Adams of Oak Hill (Va.), and Muhammad of Bishop Gorman (Nev.), to perhaps have the best recruiting class in the country.
Daniel Martin is a writer and editor at JohnnyJungle.com, covering St. John's. You can find him on Twitter:@DanielJMartin_
- imforbigblue - Apr 15, 2012 at 2:18 PM
dont matter if parker picks ucla they will still suck. bazz is a ball hog who will take 25 shots a game and parker is over weight and out of shape who wont be as good in college as high school because he will have to work
- astrozac - Apr 15, 2012 at 3:20 PM
^Sounds like someone's upset he doesn't have Kentucky on his final list of schools…
- imforbigblue - Apr 15, 2012 at 8:50 PM
yeah im mad because parker whos ranked in what the 20s or 30s dont have uk listed when we just got the #1 players in noels and have the #1 class for the 4th year in a row SMH
- bowwserr - Apr 15, 2012 at 9:42 PM
SERIOUSLY GUYS. This kid Tony Parker IS NOT THE TONY PARKER OF THE SAN ANTONIO SPURS. So stop having the link on his name go directly to the Spurs' Tony Parker's profile page. How hard is that?
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