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August 4, 2015 The Patient-Centered Outcomes Research Institute is supposed to figure out which medical treatments work best. But there are sharp political and scientific disagreements over how to do that.
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August 3, 2015 Most young children who are extra choosy about what they'll eat eventually outgrow the habit. But research finds that in extreme cases, the pickiness may be linked to depression or social anxiety.
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August 3, 2015 Flashback to the 1980s, when President Ronald Reagan tried to restrict funding for Planned Parenthood. Efforts in Congress have continued since then, with the latest focused on fetal tissue research.
August 3, 2015 Twenty percent of children are picky eaters but most grow out it. Research suggests that picky eating can also be a sign for hypersensitities that can occasionally cause social anxiety and depression.
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August 3, 2015 Sometimes one person's insight transforms medicine. Dr. John Clements is one of those people. In the 1950s he discovered a slippery lung substance key to breathing, and to the survival of tiny babies.
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August 1, 2015 At the height of the epidemic, Umaru Fofana was our guide — and a one-man solution system. This summer, he stopped by NPR's headquarters for a reunion with our Ebola reporting team.
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July 31, 2015 In a small trial, an experimental vaccine protected 100 percent of people at high risk for Ebola. But more data are needed to figure out exactly how well the vaccine works.
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July 31, 2015 A series of sting videos targeting Planned Parenthood is raising questions about the field of fetal tissue research. Companies who buy and sell such tissue defend their work.
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$13.99The "It" book you absolutely must pack in your beach bag—an addictively juicy novel of celebrity love gone wrong"Readers who come for the dirt, real or imagined, won't be disappointed; there's plenty of gold in these True Hollywood hills." —Entertainment WeeklyChosen by USA Today, People Magazine, Entertainment Weekly, Good Housekeeping, Cosmopolitan, and Vogue.com as a Great Summer Read "Dishy
$9.99In this powerful follow-up to her New York Times bestselling memoir, A Paper Life, Academy Award®-winning actress Tatum O'Neal returns with an extraordinary chronicle of family, forgiveness, redemption, and commitment—a remarkable story told with honesty, humility, determination, and above all . . . love The golden child of a glamorous Hollywood couple, Tatum O'Neal had a childhood that looked,
$2.99As a seven-year-old child, Hilary Liftin poured herself a glass (or two) of powdered sugar. Those forbidden cups soon escalated to pound bags of candy corn and multiple packets of dry cocoa mix, launching the epic love affair between Hilary and all things sweet. In Candy and Me: A Love Story, Liftin chronicles her life through candy memories and milestones. As a high school student, Hilary used
The True Story of Two Friends Separated (for a year) by the OceanA funny and moving story told through the letters of two women nurturing a friendship as they are separated by distance, experience, and time.Close friends and former college roommates, Hilary Liftin and Kate Montgomery promised to write when Kate's Peace Corps assignment took her to Africa. Over the course of a single year, they exchanged an offbeat and moving series of letters from rural Kenya
Make Your Life Easier By Using This Top-Rated Book for Birthday Party Tips, Cheap Birthday Gifts, Homemade Birthday Cakes, Romantic Birthday IdeasFeast your eyes on this number one guide to getting the best birthday gift ideas, birthday party tips, cheap birthday gifts, homemade birthday cakes, romantic birthday ideas and much more.
Grandma's 10 Simple Steps to Becoming a True LadyThis book is an effort on my part to help inspire young girls in today's world to become true Ladies.In today's society, I am very disappointed in the attitude and disrespect that I see from young girls. Not only disrespect for themselves but for everyone around them.This is a very simple 10 step book on how to become a true Lady.I hope this book inspires at least one young girl to take pride in
Jokes I Can Read To You: Plus cartoons!Over 150 jokes and a bunch of cartoons especially for kids and kids at heart.Jokes are a great way to encourage reading.Book Forward - Note to parentsBy Geri CopitchIn addition to just being fun, jokes and joke telling introduce children to important skills they will need to be successful children, and later successful adults. Through joke telling even the shyest kids can practice acceptable
$2.99Are you married? Have a boyfriend or girlfriend? A fiance perhaps? Maybe a daughter who needs a little guidance in the marital department?Would you like to keep your love alive and full of life?Marriage counselors recommend Date Night as a low cost remedy to doing just that. This guide guide will give you simple 1,2,3 steps to making your Date Night Jar for under $5.00 then tips to keep the love
I Am An Ostrich, Don't You KnowWell hello there. My name is like, Val.I'm, like, an ostrich, ya know. But I bet you knew that. You're a smart one, you are.But even if you're smart, I'm a lot smarter. And I'm better looking.Don't I look just grand?Meet Val, the vain ostrich, and let her tell you all about her life and what it is like to be an ostrich in Africa.Ages 7 to 10.LearningIsland.com believes in the value of children
Twenty-Three Terrifically Tough and Tremendously Tying Tongue TwistersFabulously fun for your family and friends, these tongue twisters can trip up even the most talented talker. Green goblins giggle in a dragon's dingy domain. Worms writhe and snakes slither toward menacing mice, all while puppies prance perkily.Tongue twisters have been around since the first humans tried to speak to each other and stumbled over their words. Every language, including sign language
245+ Christmas Tips for Frugal MomsIn this book you will not only find frugal gift ideas, and age-appropriate ideas, you will also find many money saving tips, and tons of activities to do during the Christmas season that are free, inexpensive and fun to do as a family! This book is FILLED with ideas that will not break the bank during the holiday season!

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Manmohan Singh bequeathed a larger legacy than he inherited fo...Satinder Lambah, former Prime Minister Manmohan Singh's special envoy to Pakistan, who ran the backchannel with the neighbouring country for a decade, has contested the former Research and Analysis Wing chief AS Dulat's description of Singh's tenure ... Economic Times, 2 weeks ago
10 images for satinder singh
Safai karmacharis- MC admits: Over 200 deaths in 6 yrs
In a reply sought by Councillor Satinder Singh from the Municipal Corporation, authorities revealed that out of nearly 1,300 safai karmacharis, more than 200 workers have died since 2009. From cleaning eery road, footpath and nullah to collecting ...Indian Express, 1 month ago
Satinder Singh to Lead Structural Design Projects at Parsons Brinckerhoff
425 Market Street San Francisco, CA 94101 Parsons Brinckerhoff 212-613-8841 June 15, 2015 SAN FRANCISCO, CA - Satinder Singh is joining as an engineering manager leading the structure group in the San Francisco office of Parsons Brinckerhoff, a ...Noodls, 1 month ago
Indian Foreign Policy: Why all stakeholders need to introspect
By Tridivesh Singh Maini There have been numerous debates about the need for a major revamp in India's diplomatic corps, the Indian Foreign Service. It is not just committees set up by the government, including the Pillai Committee ...South Asia Monitor, 1 week ago
Cops identify man who gave Tomar degrees
After grilling former Delhi law minister Jitender Singh Tomar for 10 days, the Delhi police has finally identified the source of his fake B.Sc certificates, sources said. The owner of a primary school in Shakurpur was picked up on Friday for ...Hindustan Times, 1 month ago No bail for Tomar, L-G appoints prosecutor The Statesman, 1 month ago Cops fail to find Tomar's 'degrees' Deccan Herald, 1 month ago Kapil Mishra Replaces Tomar as Delhi Law Minister New Indian Express, 1 month ago
Shabana Azmi is a living legend: Satinder Sartaj
New Delhi, Jul 17 (PTI) Punjabi Sufi singer-poet Satinder Sartaj, who is turning actor with Hollywood project "The Black Prince" in which he will share screen with Shabana Azmi, says the veteran actress is nothing less than a "living legend". The ...Press Trust of India, 2 weeks ago Shabana is a living legend: Satinder Sartaj Afternoon Despatch & Courier, 2 weeks ago Shabana Azmi is nothing less than a living legend: Satinder Sartaj Odisha Samaya, 2 weeks ago
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No talk between Manmohan Singh and media at book release event in Delhi
Jul 11, 3:17 pm New Delhi, July 11 ( ANI ): Former Prime Minister Dr. Manmohan Singh attended a book release function organised by the Ananta Aspen Centre at the WWF-India Auditorium here on Friday evening. Dr. Singh was among the ...Ani News, 3 weeks ago
I have faith in my fans: Satinder Sartaj
I have ample faith in my fans, they have accepted me as a Sufi singer and I am sure they will embrace me with open arms as an actor as well, said Satinder Sartaaj at an event in Chandigarh on Tuesday. Apart from being a popular Punjabi singer, ...Hindustan Times, 3 weeks ago
Cities Education HT Chandigarh Newspapers Amritsar, June 21 -- District education officer Amritsar (secondary) Satinder Bir Singh on Saturday announced change in the schedule of counseling session for meritorious schools. The counseling is now ...HT Syndication, 1 month ago Amritsar's only-girl govt schools recount problems before state education minister HT Syndication, 1 month ago
No cop at Bhindrawale village, stadium breathes new life into memories
Children playing in the stadium named after Jarnail Singh Bhindranwale in Rode, Moga. While tensions owing to the 31st anniversary of Operation Bluestar continue in Jammu, Ludhiana and Amritsar on Saturday, there is not a single policeman posted in ...Indian Express, 1 month ago
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Sept. 11 About More Than Hockey in NY
Almost everyone can recall the events that happened 11 years ago today.
In hockey, no one was more affected by the Sept. 11 attack than the New York Rangers, who were set to kick off the 2001 season in weeks.
The terrorist attacks that killed several thousand civilians and first responders hit heavily throughout the entire country, but in New York, everything was taken, including a piece of mind.
For the first time in a very long time, sports didn't matter.
It didn't matter that the Rangers were supposed to be preparing for a hockey game down the road, and that they would be facing the Carolina Hurricanes to open the season in less than a month.
Instead, questions circulated about the safety of the United States, not only in sports, but in everyday life.
Shortly, but surely, life inched back towards normality.
Although none of the Rangers players that are currently playing were directly affected by the attacks — in fact, many of them were yet to play in the league in 2001 — they understand how important the day was to the city, fans, and citizens of America.
In recent years, the team has taken steps to reach out to many of those families affected. On last years anniversary — the ten year mark of the treacherous attacks — the entire Rangers team visited three firehouses in Manhattan, each of which responded to the attacks on that fateful morning.
In the events last year, the Rangers supported families of victims that were lost in the attacks at the World Trade Center, including wives, husbands, and children.
That day, the Rangers were donning their traditional home blue jerseys as their double-decker tour bus made its way to the three firehouses they were visiting, and eventually, a reception at Tower 7 that overlooks the Ground Zero site.
Every day during hockey season, the Rangers put those same uniforms on, and are recognized as heroes. But on that day, they were recognizing heroes — everyday people who risked their lives for other everyday people.
New York is a famous city. Its the home of famous people, and plays host on a daily basis to several famous sports teams.
Without a doubt, the New York Rangers are one of those teams.
But on that day 11 years ago, New York became known for something else. It became the home of a place that, usually separated in animosity, came together to help unite a country that desperately needed it.
For one day, at least, something is more important than sports. It's more about the Rangers, and more about every other team that plays in that city.
It's about being an American.
Email me: firstname.lastname@example.com
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Possible Breakout NHL Stars In 2015-16
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My Scripts At Amazon Studios
View Single Post
Junior Schmoe
Join Date: May 2006
Posts: 121
Hey dude,
I had a bit of a read of Dead of the Night. First off I'll tell you I'm an amateur screenwriter as well so I spose you may take my words with a grain of salt. First off the format of your script isn't correct. I'd suggest using a program like final draft or even the old sophocles program if you can get a hold of it because sometimes it was a little difficult to read which will put off a professional reviewer especially if the formatting is incorrect. One thing is that unless the time of day changes you don't need to specify that it's morning or evening everytime a scene changes. You only need to specify this when the time of day changes even if it's been 10 scene changes between night and day.
Some sentences of your characters dialogue seemed to be unrealistic and may sound strange when read aloud. I fixed a lot of dialogue in my own script just reading aloud a line and realizing that how I typed it wasn't how people would construct their sentences while talking.
The storyline of an outbreak of a virus that turns people into flesh eating maniacs has been done many times before and even though you call them ghouls and they have sharp teeth and claws I would still feel like I've seen this story many times before so on that subject it's a bit meh for me.
But your writing definitely wasn't the worst I've ever seen by a long shot and the dialogue wasn't all bad that's for sure. I didn't read it all as I felt I'd seen this story so many times before as I have already said but overall I'd say you should polish the formatting of your script and maybe read aloud the dialogue to see if you feel people would actually "say" something the way you typed it. Keep up the good work dude.
I must say though I'm definitely going to look into this amazon studios site. I've polished up a script I've called The Lonely and I'm about to register it with the Australian Writers Guild. I may end up submitting it to this site as well and I plan to submit it to Script Pipelines contest after I register it. How have you found Amazon Studios so far?
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Saint Louis MO, United States2 weeks ago on spreadmyad.com
For sale $6,000ac 1998 hatchback
1998 Honda Civic Hatchback Swapped with B18C from a Honda Integra type-R Obviously it runs perfectly. You have to see it to believe the condition it's in. It looks newer than my 2011 civic. Text me for video or better quality pictures. Tons of bolt ons.. Cold air intake, header back exhaust, act clutch and pressure plate, ...
civic type r,
honda civic type r
Hartford 06150, CT, United States1 month ago on autozin.com
For sale $7,550honda crx green 1989 10,000mi coupe
1989 jdm- Honda Civic crx Si R imported from Japan right hand drive Engine has approximately 10,000 miles cylinders are sleeved Arp studs and bolts 2005 front end and full suspension coil-over Rota drag wheels new tires original crx leather seats true carbon fiber hood true carbon fiber mirrors 4 wheel disk brakes Garrett turbo intercooler golden ...
right hand drive honda civic,
crx si
New York 10002, NY, United States1 month ago on autozin.com
For sale $3,600acura integra black 1998 gasoline
...hub. D2 Adjustable Coilovers height and damping. D2 Lower controller arms.Rear Strut brace.jdm b18c block. B16 head.Intake, Header, Exhaust. Brand new oem Radiator. New lower ball joints, ...
integra type r,
jdm cars
El Cajon CA, United States1 month ago on craigslist.org
For sale $1honda civic black 1994 100mi hatchback
Up for sale is a very clean and complete 1994 Civic Si Hatchback Shell. Easily one of the cleanest in the country. It has been fully restored and is in excellent condition inside and out. I keep it garaged and have done so since the day I bought it well over 10 years ago. I just blew my motor, ...
civic si shell,
honda civic si shell
Brownsville 15417, PA, United States1 month ago on trucks2cars.com
For sale $3,000acura integra 1995 coupe
Acura : Integra gsr gsr integra with A jdm B18C motor and slyvia conversion body kit
jdm pennsylvania
Naples FL, United States1 month ago on autozin.com
For sale $12,000acura integra white 1996 gasoline
Squaretrade ap6.0 jdmforlife Store this auction is for A 1996 acura integra gsrcustom built read everything...im only selling due im looking to buy A house and start A new project serious inq email me and ill send you my number if you would like to know more Built 1996 Acura Integra gsr fully built receipts for everything ...
florida jdm
Orlando 32822, FL, United States1 month ago on autozin.com
For sale $8,500acura integra black 1994 76,844mi gasoline
1994 Acura Integra gsr Converted into 98 integra type R Please Read Carefully. I would like to start out by saying this is a very well put together Integra and the 1 and only reason is because I know it will get stolen in my area if it parked anywhere besides my garage Plus I could use the funds ...
Fresno 93764, CA, United States3 days ago on craigslist.org
For saleacura black 1996 hatchback
Description: 1996 Honda Civic midori hatchback Engine 1999 b18c Type R swap from hmo Usdm Itr Manifold w/port matched tb Type R Headers Vibrant Catback aem Fuel Rail aem Fuel Pressure Regulator Aem Fuel Pressure Gauge P73 ecu Skunk2 aluminum Radiator Upgraded fuel pump and fuel lines Ready for e85 Transmission 4.785final drive Itr lsd Unsprung Clutchmasters ...
Hatch 87937, NM, United States4 days ago on craigslist.org
For sale $5,200honda civic 1989
Have a 89 civic hatch for sale with a b18c full type r swap with hydro trans. Rums and shifts great. Hate to see this car go but I got a new car and no longer need this. Have a lot of stuff done to it. Just text or call me with any quesrions about it. Asking 5200 obo
San Francisco 94145, CA, United States3 weeks ago on spreadmyad.com
For sale $1acura integra black 2000 107,000mi power locks
...waters*** Have a 2000 Acura Integra gsr body with 107,000 miles Type R Engine B18c with 53k miles on it 5 speed manual with stage 3 racing clutch with short shifter Dc sports headers aem cold air intake Straight pipe exhaust aem fuel rail 16' inch black rims Power windows Power locks Sun roof Leather seats Cars registered till ...
El Paso 79978, TX, United States1 month ago on craigslist.org
For sale $4,500honda del sol black 1997 coupe
...in the usa very rare!!! * jdm dohc vtec 1.8 integra type-R full swap. B18C, lsd tranny, no grinds, no popouts. 45K on engine. *hasport motor mounts. *skunk 2 coilovers with camber kit front, and back. *new stage 1 exeddy clutch. *4 T0 1 header, and full exhaust. *air intake. * 16" speed lite rims, with new 205/50/16 ...
Jersey City 07395, NJ, United States1 month ago on craigslist.org
For sale $3,500acura integra black 1995 coupe
...body and aprox. 70-75 on motor..motor is 98 spec integra type r motor(b18c) raceland coilovers, del sol seats, intake, stock 4-1 header , chipped p28 ecu....basically ...tickets...thank you call me at i am trying to trade this for a street bike mostly or just cash thank you! please ignore...integra hatch b18c gsr type r ... ...
Greensboro 27402, NC, United States1 month ago on craigslist.org
For sale $4,300ac blue 1995 convertible
Selling my 1995 Honda del Sol with a jdm b18c swap done by Blue Ridge Motorsports motor has approximately a hundred and twenty thousand miles on it Transmission is the same with a 3 puck racing clutch received cv joints tie rod ends upper and lower ball joints new wheel bearings control arms strut and coil spring adjustable coil ...
Salem 06420, CT, United States1 month ago on craigslist.org
For sale $5,200seat red 2000 3,000mi coupe
...my 2000 integra gsr it has 138k on the odometer and 35k on the new b18c true jdm motor. The car does have a new clutch new timing belt all was done when motor was put in about 3,000 miles ago the car runs and drives great Paint is amazing 9.5/10 inside is in good condition just ...
Cocoa Beach FL, United States1 month ago on craigslist.org
For sale $6,000acura integra black 2001 60,000mi SUV
I'm selling my 2001 acura gsr with a jdm b18c. Car runs strong and has many goodies I will discuss with interested purchasers. Car has solid black with blue in the paint. Sitting on strings with white 16x7.5 rota slipstreams. Car has 160,xxx on dash but the motor was put in just over a year ago ...
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Studio East
Although we're still two years away from the first pace being taken, shot being 'put' and stroke being swum, the Olympics is of course already making waves in London. Yes, we know about that logo, and those mascots, but the amount of creativity going on around the main events is staggering. One such initiative is Studio East, an initiative being introduced at the in-progress shopping hub, Westfield in Stratford. Their idea is to let cultural icons (including Tom Dixon and Tracy Emin) award commissions to the finest up-and-coming east London creatives to create new work for the site. Did I just hear dull shopping centres and malls all over the globe slump with envy?
- Danish illustrator Rune Fisker's clean, windswept surrealism
- Filmmaker Alice Dunseath presents a meditative reflection on life
- Edinburgh graduate Jack Fletcher's beautiful woodcut illustrations
- There Is' ace new typographic projects for Wired and New York Times magazine
- Clase bcn's bright but elegant identity for a Barcelona concert hall
- Craig Gibson's photography is sincere and refreshing
- Yolanda Dominguez asks kids to describe what they see in fashion campaigns
- Street photography shot on an iPhone during fake phonecalls by Jay Giampietro
- Tokyo 2020 Olympic and Paralympic logos unveiled
- Illustrated campaign for Volkswagen uses parents lying to children as a metaphor
- Should creatives ever accept unpaid work? We ask some seasoned experts
- We get a sneak peek of TASCHEN's new book documenting 50 years of Pirelli


text:
Paula Poundstone Set for Pair of Shows at Vermont's Town Hall Theater Tonight
Emmy-winning comedienne PAULA POUNDSTONE is famous for her razor-sharp wit, drawing from her own complex life: three kids, 13 cats, motherhood, demanding job, crazy travel schedule, her frustration at getting older, and a bag of neuroses, including her famous inability to ever shut up. In other words: she's just like many of us.
She'll perform live in Middlebury's intimate Town Hall Theater for two performances on Saturday, March 8, a presentation of Kingdom County Productions.
Poundstone is very funny, but what separates her from the pack of comics working today is her ability to be spontaneous with a crowd. No two shows are the same. It's not that she doesn't repeat material. She does, but always with a different shape and trajectory drawn from the moment. Paula's exchanges with the audience are hilarious but never mean or done at a person's expense.
One of Comedy Central's "Greatest Stand-Ups of All Time," Paula Poundstone is a frequent guest on The Tonight Show, Letterman, A Prairie Home Companion, and NPR's Wait Wait! Don't Tell Me! Poundstone is so quick that audience members often leave complaining that their cheeks hurt from laughter.
"Paula often plays very large theaters, because she's so popular," says THT executive director Douglas Anderson. "But very few people get the chance to see her in an intimate setting like THT. It's going to be a very special evening."
Performances are at 6:00 pm and 8:30 pm. Tickets are $56 + tax, and may be purchased at www.townhalltheater.org, 802 382-9222, at the THT Box Office (daily except Sunday, noon-5 pm) or at the door, if available. A cash bar and snacks will be available. Please note that Paula Poundstone's show may contain some adult situations and language.
About Author
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Jewelry for You! How to Make Handmade Beaded Bracelets and Necklaces
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Simplest Button Necklace
By: Theresa Cifali
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Ready to make the simplest button necklace ever? Check out this DIY necklace tutorial from Theresa Cifali and discover how easy it is to turn some cute buttons into a colorful statement necklace.
- Blumenthal Lancing Button Coordinates
- Bails
- 28 guage wire cut into 5" pieces
- Wire cutters
- Needle nose pliers
- E-6000 (glue)
- Leather cord
- Glue a bail to the back of the largest button of the set using E-6000 glue. This is an extremely strong adhesive. You want to be careful not to get any on your hands and work in a well ventilated area. Let the glue dry overnight. Tip: Glue several bails on at once so that you have them handy and ready to go.
- Once your bails have completely dried, you are ready to start assembling your pendant. Gather your materials so that you have everything you need.
- Shape your wire into a U. Thread your buttons through starting with the largest and working your way to the smallest. You want to make sure that the ends of the wire are poking out from the top of the buttons.
- Thread 3 of the micro beads onto one of the wires.
- Push the beads up about a finger width and bend it slightly so that the beads are above the bend.
- Take the opposite wire and thread it through the beads. Now both wires should be threaded through the beads together from opposite directions.
- Using your needle nose pliers, pull the wires until the micro beads lay flush with the top button.
- Then push the wires down into each button hole so that the come out of the back.
- Twist the wire in the back once as close to the button as you can get. Then push the wires back through to the top…one through each hole. With your wire cutters, trim the excess wire so that they are short enough to bend and manipulate so that no sharp points will stick out.
- Use your needle nose pliers again to bend and wrap the short stubs of wire so that no points are sticking out. It should look like this:
- Cut a piece of leather cord long enough to fit over your head once you've knotted it. Thread your pendant onto the cord and tie in a knot.
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I like greek food and wanted to try an authentic greek restuarant for my birthday. This was the first visit for my family and I. We made reservation for 5pm and couldn't be seated until the entire party of 8 arrived. By 5:15 everyone had arrived and though the resturant was by no means crowded, it took them an additional 10 minutes to prepare the table. Once we were finally seated our waitress was friendly and attent... view moreLike this review?Yes|Flag AbuseProvided by Citysearch
Acropolis Restaurant
Today:11:00 am - 10:00 pm
Tomorrow:11:00 am - 10:00 pm
4718 Eastern Ave,
Baltimore, MD 21224
(410) 675-3384
Book a Table
Business Details
in Business
- Hours:
Regular Hours
- Extra Phones:
Fax: (410) 675-7882
- Payment method:
- amex, diners club, discover, master card, visa, all major credit cards
- Neighborhoods:
- Southeastern Baltimore, Fifteenth Street
- Other Link:
- Other Email:
- Categories:
- Mediterranean Restaurants, Take Out Restaurants, Greek Restaurants, Banquet Halls & Reception Facilities, Family Style Restaurants, Restaurants
I have been to all the greek restaurants in town, the Acropolis is the best weve tried. The small greek salad is enough for 4 people and their house dressing should be bottled. The lamb giouvetsi is to die for, dolmades and spinach pie better then mom's, the lamb chops were so good I would have eaten the bones if I could. My friends had crabcakes which had no filler and couldnt believe a Greek restaurant had the best... view moreLike this review?Yes|Flag AbuseProvided by Citysearch


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Oil $52.94 Gold $1 095.99
U2 frontman Bono has designed a sunglasses collection for an eyewear brand to benefit an eyecare charity.
Road rage. It's getting worse, isn't it? Stay alert to the early signs of road rage and follow these five steps to reduce your risk...
Samsung has announced an Unpacked 2015 event in August, with a Galaxy Note 5 and S6 Edge Plus expected.
An emergency was declared as the first elephant was poached on western border of Kruger National Park.
Michael Jackson's father Joe Jackson feels "grateful to be alive" after suffering three heart attacks.
The DA has said that Prasa's former head of engineering Daniel Mthimkhulu should pay back all the money he earned in the position.
Read more ›
ANC Secretary General Gwede Mantashe says the party's NEC has called on government to rapidly resolve the crises plaguing state owned enterprises.
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South Africa will undertake their longest cricket tour of India later this year to contest all three formats over a nine-week period.
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Canadian women arrested in firebomb attack in Mexico
Two Canadian women and a Mexican man have been arrested in connection with a firebomb attack on a government transportation department office and a car dealership.
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Two Canadian women are under arrest for their alleged involvement earlier this week in a bungled bomb attack on a government office in the Mexican capital.
Mexican news agencies identified the women as Fallon Poisson Ruiller and Amélie Pelletier but did not say where they were from.
Also being detained for his part in the same incident is a Mexican man identified as Carlos Lopez Marin.
The three are said to have thrown fire bombs — better known as Molotov cocktails — into the entrance of a federal office building in central Mexico City late Sunday night.
"We have a report that these were alternate installations, not the headquarters, of the Ministry of Communications," Rodolfo Rios Garza, attorney-general of Mexico City told local media.
Several cars parked at an adjacent auto dealership were also damaged in the attack.
The damage to the building and the cars appeared to consist primarily of broken windows.
According to Mexico City newspaper Excelsior, the man and two women were arrested when police on patrol saw one of the women throw a knapsack into the building. The bag was later found to contain "explosive devices," said police.
"The Department of Foreign Affairs, Trade and Development is aware of two Canadian citizens currently detained in Mexico," said foreign affairs spokesman Mathieu Roy in an email late Tuesday.
"Canadian officials are in contact with local authorities to gather addition(al) information and consular services are being provided."
Mexican government officials are linking the incident to a series of recent anti-government demonstrations that have been joined by masked activists, many of them allegedly armed with sticks or pipes. At least some of the violent demonstrators are being described by Mexican authorities as European or North American "anarchists."
The newspaper La Jornada quoted one government official — Mexico City security minister Jesus Rodriguez Almeida — as saying the two detained Canadians recently travelled to Mexico City from the impoverished southern state of Chiapas, which is marking the 20th anniversary of the founding of the Zapatista Army of National Liberation, a revolutionary group that launched an armed struggle that year on behalf of the Mexican poor.
Rodriguez did not say how he came by this information.
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My Nonprofit Reviews
Review for Environmental And Energy Study Institute (Eesi), Washington, DC, USA
Working at EESI was a truly wonderful experience, both for the nature of the work they do with Congress as well as for the team-work and relationship building within the organisation itself. It was for me a situation where I looked forward to coming to work every morning, knowing I would expand my perspective on clean energy and learn about new, alternative and innovative energy and policy solutions.
I was very impressed by the staff and their dedication which seemed never to falter, and for the general collaboration between staff members.
Most of all, I was inspired by the breadth of impact a small non-profit with limited funds could achieve, through efficient and high quality work. I strongly believe in and support all the work they do educating Congress on clean energy and climate change.


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All Schools
(3) All Schools
(3) High Schools
(1) High Schools
(1) Elementary Schools
(3) Elementary Schools
(3) Preschools
(1) Preschools
(3) All Schools
(3) High Schools
(1) High Schools
(1) Elementary Schools
(3) Elementary Schools
(3) Preschools
(1) Preschools
There are 3 private schools in Delaware serving 220 students.
Special education schools primarily serve specific student groups such as those that may be hard of hearing, deaf, speech impaired, health impaired, orthopedically impaired, mentally retarded, seriously emotionally disturbed, multi-handicapped, visually handicapped, or deaf and blind.
Delaware with Special Program Emphasis Private Schools
- School Location Grades Students
Wilmington1408 Clifford Brownwalk
Wilmington, DE 19801
(302)652-3011Special Program Emphasis(Non-sectarian)Gr. PK-KG | 63 students
New Castle903 E. Basin Road
New Castle, DE 19720
(302)738-3337Special Program Emphasis(Calvinist)Gr. K-12 | 137 students
NewarkPo Box 947
Newark, DE 19715
(302)456-9838Special Program EmphasisGr. UG | 20 students
State Statistics
|About This State (DE)
|(DE) State Statistics
|Nationwide Statistics
|Population (Approximate)
|892,273 people
|304,788,332 people
|Age 25+ w/College Degree
|Median Household Income
Recent Articles
Updated July 12, 2015
Many parents tend to dismiss the idea of sending their children to private school without exploring it in depth. We explore this and several more related subjects.
When it comes to choosing a private school, there are so many choices to consider that the project can be a huge challenge to most of us. We offer some help and advice to help you get started.
Sending your child to a foreign language school makes good sense when you have been posted to this country from abroad and in other circumstances as well.


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Yeah… Amerika already proved that to be false! ;) …
Comment on Enormous Cattleya Touki Ranbu Figure by Anonymous:
Yeah… Amerika already proved that to be false! ;)
Anonymous made other comments on this post:
- Enormous Cattleya Touki Ranbu Figure:
more like CATTLEya…
- Enormous Cattleya Touki Ranbu Figure:
Gigantic boobage like that is not attractive. If Cattleya were to get some decent breast augmentation done she'd almost be a fine MILF.
- Enormous Cattleya Touki Ranbu Figure:
There's a reason her name is CATTLEya.
- Enormous Cattleya Touki Ranbu Figure:
What the hell is that thing I feel like anyone who fucks her would be arrested for beastiality
- Enormous Cattleya Touki Ranbu Figure:
Boobatripolis, she can be seen from a Satellite radar from space!
Recent comments by Anonymous:
- Nurse Ero-Cosplay by Rin & Ran Higurashi Fever Inducing:
big rack, nice body, and good looks, she passed the triple attractive combination….the last would be checking her personality if you really want to date her…
- One-Punch Man PV A Total Hard-Hitter:
the author design saitama looks in order to suit westerner taste, I hope westerner can accept saitama just like other superheroes in DC and marvel…
- Outdoor P*****g Exhibitionist Quite Scandalous:
nice censured…
- Digimon Adventure Tri PV Battles It Out:
That sounds cool, though am I the only one who wants to see the first Digimon-movie, that is to say the horribly ass-rape cut of three movies into one remade so that we can finally see the epicness of them? I mean I watched the first one in Japanese to gain my hope for humanity back after seeing the cut one. Why would you even cut 3 seperate movies into 1 to begin with?
- Shimoseka Gushing With Perverse Humor:
I think: 1. this anime is closer to tokusatsu in form of anime (just like what you see in into song) 2. anna actually possessing superhuman strength which is common in tokusatsu heroes and villain, and also super libido which make her can do instant "leaking" when she sense okuma presence 3. a girl chase you to the corner of the earth just to extract your "love nectar" in "docking" style is far higher level than a mere prostitute, since prostitute ask for money and just advertise through …


text:
STARKVILLE, Miss. (AP) Middle Tennessee coach Rick Stockstill needed all of about five seconds to describe why No.
STARKVILLE, Miss. (AP) Midway through the college football season, No.
West Virginia came into Saturday's game at Texas Tech in the drivers' seat for the Big 12 title, undefeated and eyeing a shot at the BCS championship and with quarterback Geno Smith acclaimed as a
STARKVILLE, Miss. (AP) Tyler Russell threw for 291 yards and two touchdowns, LaDarius Perkins added 101 rushing yards and a touchdown and No.
STARKVILLE, Miss. (AP) Mississippi State might have a really good football team.


text:
Ethan longs to escape his small Southern town. He meets a mysterious new girl, Lena. Together, they uncover dark secrets about their respective families, their history and their town. Starring Alice Englert, Viola Davis, Emma Thompson. In cinemas 22 February.
Probably one of the silliest movies to come out this year, Pixels' complete lack of plot doesn't detract from the nostalgia trip and the adorableness of Q*bert. Read More »
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Badly written, directed and acted: Kidnapping Freddy Heineken is one of the year's most inept and just plain bad "serious" films. Read More »
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South AfricaDiscovery Partner Markets
South AfricaMurray & Roberts
HousesR 3 500 000
TownhousesR 1 750 000
HousesR 1 600 000


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Thanks for visiting the Texas A&M University Women's Soccer scholarship and program information page. Here you will get specifics on the college and details on their Women's Soccer program like who to contact about recruiting, names of past alumni, what scholarship opportunities are available and how to start the recruiting process.
Texas A&M University Women's soccer Program Coaching & Recruiting Staff
If you are trying to get recruited it is critical to know who to get in front of - and NCSA has the information you'll need. The Head of the Texas A&M University Women's Soccer program is Gerald G. Guerrieri. Other major personnel are:
5,200-acre campus in College Station (population: 67,890), 90 miles from Houston; branch campus in Galveston. Served by air; bus serves Bryan (five miles); major airport and train serve Houston. School operates transportation from campus to student apartments and parking lots. Public transportation serves campus.
Fernanda Vallejo
Class of 2014
Women's Soccer
Rodney Anderson II
Class of 2015
Trevor Elbert
Class of 2015
Lizette Chapa
Class of 2015
Women's Track
Logan Hendrix
Class of 2015
Men's Track


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Specifically, the last line. I still tihnk Israel should be working towards peace with Syria because I honestly don't believe he's as committed to Iran as Israel prefers to think. Too bad Israel's politicians refuse to listen to the advice of those in its intelligence community who believe the same.
If selected for publication, it will appear as soon as possible on Haaretz.com.


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NEW DELHI Two navy officers were unaccounted for on Wednesday after an incident aboard a submarine, months after an accidental weapons blast caused the deaths of all 18 submariners on a Russian-built vessel.
Seven crew members out of more than 60 aboard the diesel-powered vessel were airlifted to a naval hospital after inhaling smoke, but the two officers could not be found, said a navy official who declined to be identified.
The INS Sindhuratna, a Soviet-built Kilo class vessel, was on a training exercise off the Mumbai coast when smoke triggered the automatic closure of hatches, possibly isolating the officers.
The submarine was still seaworthy and making its way back to base, while an investigation was being opened into the cause of the incident, which appeared to be less serious than the dockside submarine blast in Mumbai last August.
In that incident, an accidental weapons detonation and fire killed everyone on board the INS Sindhurakshak. It was the most serious maritime loss for India since a 1971 war with Pakistan.
(Reporting by Sruthi Gottipati; Writing by Douglas Busvine; Editing by Robert Birsel)
Trending On Reuters
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Ketan Desai's legal troubles bedevil World Medical Association
Next year, Dr. Ketan Desai is slated to head the World Medical Association (WMA), guardian of the Hippocratic Oath. The WMA is standing by him, even as he battles conspiracy allegations in two Indian courts. Desai has been facing allegations that he conspired in 2009 to have the Medical Council recommend that a private medical college be allowed to add more students. Full article
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Harald Haas can send movies, online games, even Skype calls through a household lightbulb. Meet Li-Fi, his LED-based alternative to Wi-Fi »
OPOWER is using psychology and design to cut Americans' power use. And now it's coming to Britain »
Nathan Myhrvold is an inventor who has Bill Gates and Stephen Hawking on speed-dial. He wants to zap Malaria, create limitless energy, eradicate polio, fix the climate – and reinvent inventing. »
A guide to resetting iTunes Match and performing a "do-over" for iCloud, without losing playlists, metadata or playcounts »
How artist Olly Moss and developer Campo Santo illustrated the stunning national park setting of Firewatch »
N++ is the final version of a devastatingly hard freeware PC platform game, exclusive to PS4. With the game out this week, Michael Rundle returns to the glory and tragedy of an old gaming flame. »


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This invention relates to a material that degrades after implantation into a patient's tissue, and resorbs into the patient's body, which material is manufactured of polymer, copolymer or polymer alloy. The material has a non-crystalline, i.e., amorphous structure and is molecularly oriented and reinforced by mechanical deformation. Further, the material can be formed into surgical devices, such as screws and pins, for implantation into a patient.
1. A material that resorbs after implantation into a patient's tissue comprising a resorbable, thermoplastic polymer, copolymer or polymer alloy, said material having an amorphous region that is mechanically modified to provide a molecularly oriented, reinforced structure.
2. The material as set forth in
3. The material as set forth in
4. The material as set forth in
5. A surgical implant formed from the material of
6. A surgical implant manufactured from the material of
7. A surgical implant manufactured from the material of
8. The material as set forth in
9. A method for manufacturing the material of
selecting a starting composition from a group of resorbable, thermoplastic polymers, copolymers polymer alloys having an amorphous region, and
mechanically modifying the starting composition to molecularly orient and reinforce the amorphous region, yielding the molecularly oriented, reinforced material of
10. The method as set forth in
forming the material into a surgical implant having a longitudinal axis, wherein the molecular orientation of the material is substantially parallel to the longitudinal axis of the implant.
11. The method as set forth in
12. The method as set forth in
forming the material into a surgical implant having a longitudinal axis, wherein the molecular orientation of the material is substantially twisted, threaded or spiral in relation to the longitudinal axis of the implant.
13. A surgical implant formed from the material of
14. The material as set forth in
15. The material of
16. The material of
[0001] This application is a continuation of U.S. patent application Ser. No. 09/043,720, filed Aug. 26, 1998, the disclosure of which is incorporated herein by reference.
[0002] The invention relates to under tissue conditions degradable material.
[0003] In surgery, it is known to employ implants manufactured of biodegradable (under tissue conditions absorbable) polymers for connecting tissues together, for separating tissues from each other, for temporarily replacing tissues partially or entirely and for guiding the healing or growth of the tissues. It is known to manufacture of partly crystallized thermoplastic, biodegradable polymers strong implant materials by stretching elongated blanks, such as fibres or bars in a manner that the crystalline structure of the materials is modified and directed (oriented) increasing the strength and the stiffness of the material in the orientation direction. Publication U.S. Pat. No. 4,968,317 presents partly crystalline, biodegradable biomaterials, oriented by the drawing technique which can be used when manufacturing e.g. various equipments for fixation of bone fractures. Publication EP-03211761 presents a method for manufacturing oriented, partially crystalline, biodegradable material by cooling the thermoplastic polymer to a temperature lower than its glass-transition temperature, in which the nucleation of the crystals takes place, and by reheating the material to a temperature which is higher than the glass-transition temperature of the material but lower than its melting temperature, and by stretching the material under these conditions to gain orientation.
[0004] Publication WPI ACC No: 89-22047O/3O presents a surgical biomaterial consisting of molecularly oriented lactic acid polymers or its copolymer with glycol acid, having a crystal content of 10 to 60% in the material and a compression bending strength of 160 to 250 MPa.
[0005] Partially crystalline biodegradable polymer materials can be used for manufacturing e.g. various rods, screws, plates etc. to be employed e.g. when repairing bone fractures or damages in connective tissue. The following publications disclose results of applying these types of materials in surgical use: P. Rokkanen et al.: "Utilisation des implants biodegradables dans le traitement chirurgical des fractures et au cours des osteotomies", Orthop. Traumato 12, (1992). pp. 107-11; EX Partio et al.: "Immobilisierung und Fruhmobilisierung von Malleolartrakturen nach Osteosynthese mit resorbierbaren Schrauben", Unfallchirurgie 18(5), (1992), pp. 304-310; H. Pihlajamaki et al.: "Absorbable pins of self-reinforced poly-l-lactic acid for fixation of fractures and osteotomies", J Bone Joint Surg 74-B(6), (1992). pp. 853-857; T. Yamamuro et al.: "Bioabsorbable osteosynthetic implants of ultra high strength poly-L-lactide. A clinical study", Int. Orthop. 18, (1994), pp. 332-340.
[0006] Crystalline configuration as such gives the non-oriented biodegradable materials strength and toughness in a manner that they can be employed e.g. in bone surgery, in selected surgical embodiments, such as in healing of non-loaded bone fractures (cf. e.g. S. Vainionp{umlaut over (aa)}. P. Rokkanen and P. T�rm�l�d: "Surgical applications of biodegradable polymers in human tissues", Prog. Polyrn. Sci. 14, (1989), pp. 679-716).
[0007] Although the partially crystalline biodegradable materials have good, in case of oriented materials even excellent, strength properties, and the strength retention time in vivo can be controlled to a typical term of 1 to 12 months, the disadvantage is very slow degrading of the crystal phase of the material. Numerous researches have found out that partially crystalline, biodegradable materials first degrade at their amorphous (non-crystalline) parts, since degrading starts and is easiest in the amorphous areas of the material, which are situated between the crystalline areas (cf. e.g. E. W. Fischer, H. J. Sterzel, G. Wegner G.: "Investigation of the structure of solution grown crystals of lactide co-polymers by means of chemical reactions". Kollold-Z. Polym. 251, (1973), pp. 980-990). As a result of the said heterogeneous degradation, in the last phase of the polymer absorbing, mainly crystalline, very slowly degradable particles are created. In some tissues, these particles can cause harmful side effects, such as swelling in the tissue and pain (cf. e.g. E. J. Bergsma et al.: "Foreign Body Reactions to Resorbable Poly (L-lactide) Bone Plates and Screws Used for the Fixation of Unstable Zygomatic Fractures", J. Oral Maxillofac. Surg. 51, (1993) pp. 666-670).
[0008] However, since the non-crystalline (amorphous) biodegradable polymer material has no slowy degradable crystal structures, degradation of amorphous polymer is under tissue conditions taster than degradation of partially crystalline polymer, and due to the lack of crystalline structure, no such harmful tissue reactions can occur when the amorphous polymers are degrading, as described e.g. in the above mentioned publication E. J. Bergsma et al. However, a drawback with amorphous biodegradable polymers is their poor mechanical strength properties. As for the mechanical properties, the amorphous biodegradable materials are either very ductile ("rubber-like"), if their glass-transition temperature is under the body temperature, or, on the other hand, they are hard and glass-like if their glass-transition temperature is over the body temperature. In every case, the amorphous polymers have relatively weak strength properties.
[0009] Insufficient strength of the amorphous, biodegradable polymer implants is found in clinical research as high frequency of breaking of fracture fixations. E.g. the publication K. E. Rehm, H.-J Helling, L. Claes: "Bericht der Arbeitsgruppe Biodegradable Implante". Akt. Traumatol. 24 (1994), pp. 70-74 presents clinical results from 57 patents. In the research, various fractures in the cancellous bone area were fixated with biodegradable rods manufactured of amorphous poly-L/DL-lactide (with L/DL ratio of 70/30). In the post-surgical follow-up of the patients, a dislocation of bone fragment was noticed in four patients, which signifies that this complication was found in 7% of the patients. Further, with two patients (3,5% of the patients) dislocation of the rod head was found. Thus, the total proportion of complications was high: 10,5%. Dislocation of bone fragment and dislocation of rod head show that the strength of the amorphous lactide copolymer, particularly the shear strength, was not sufficient for providing safe healing. This result differs clearly e.g. from the clinical research of H. Pihlajam�ki et al.": "Absorbable pins of self-reinforced poly-L-lactic acid for fixation of fractures and osteotomies", J. Bone Joint Surg. (Br) Vol. 74-B, (1992), pp. 853-857, using rods of a corresponding type for the fixation of fractures and osteotomies in cancellous bone area, which rods were manufactured of partly crystalline, oriented (self-reinforced) poly-L-lactide. The research comprised 27 fixation-operated patients, in whom no bone fragment dislocations or rod dislocations were found in the post-operation follow-up (8 to 37 months); i.e. the degree of complications was 0%. Since the shear strength of partially crystalline, oriented polylactide rods is more than double compared to that of amorphous, non-oriented polylactide rods (the shear strength of rods used by Pihlajamaki et al. was 100 to 180 MPa and the shear strength of rods used by Rehm et al. was measured 46 to 54 MPa, cf. Example 1), it is obvious that the high proportion of complications in the research of Rehm et al. was due to insufficient strength properties of the material used in their study. On the other hand, since no slow-absorbtion, crystalline phase is present in the amorphous polymer, absorbing of the amorphous polymer takes place, after loosing the strength, faster than absorbtion of partly crystalline polymer. For example according to the publication of Rehm et al., rods manufactured of amorphous poly-L/DL-lactide were absorbed almost entirely in two years under tissue conditions, whereas according to Bergsma et al., there was a significant quantity of crystalline poly-L-lactide present at the operation site in the patient even after three years and eight months after the implantation. Also Y. Matsususe et al. ("In vitro and in vivo studies on bioabsorbable ultra-high-rigidity poly(L-lactide) rods, J. Biomed. Mater. Res. 26, (1992), pp. 1553-1567) noticed that 18 months after the placing of the implant, a significant amount (−30%) of partly crystalline poly-L-lactide remained in the laboratory animals.
[0010] Since the biodegradable implant becomes useless in the patient's system after having lost its strength, it would be advantageous that the implant would absorb as soon as possible after loosing its strength.
[0011] Thus, crystalline nature gives the biodegradable material its good initial strength, but it retards the final absorbtion of the polymer after the material has lost its strength, and it may even cause harmful chronic complications in certain embodiments. The amorphous material, in its turn, absorbs fast but causes the patient risks when healing (danger of dislocation), because of its poor mechanical properties.
[0012] It has been. surprisingly discovered in this invention that the drawbacks of known partly crystalline and, on the other hand amorphous biodegradable surgical implants can be efficiently eliminated by using in their manufacturing. instead of known materials, amorphous, biodegradable polymer, copolymer or polymer combination oriented and reinforced (self-reinforced) by means of draw technique. The present invention thus presents molecularly oriented, self-reinforced, amorphous, biodegradable surgical biomaterials, their use in the manufacturing of surgical implants, their parts or compounds, and surgical implants, their parts or compounds manufactured of said biomaterials. Said biomaterials and implants manufactured thereof can be used in surgery for connecting together tissues or parts thereof, for separating tissues or parts thereof, for temporarily replacing tissues and/or for guiding healing or growth of tissues. The selfreinforced materials and implants in accordance with the invention surprisingly combine the advantageous properties of known biodegradable, partially crystalline and, on the other hand amorphous materials, and simultaneously eliminate the drawbacks of the materials. Materials of the invention have surprisingly an especially good shear strength, they are tough, they retain their strength for long (typically several months in vivo), when slowly degradable polymer is used as raw material, and after having lost their strength they absorb faster than known strong, partly crystalline, corresponding biodegradable biomaterials. When tested, reinforcing can be seen as an increase of the strength values in the entire macroscopic piece. Additionally, materials of the invention can be sterilized by y-radiation without them loosing too much of their advantageous properties.
[0013] To obtain the above mentioned objects, under tissue conditions degradable material according to the invention is mainly characterized by what is said in the characterizing part of the accompanying independent claim 1.
[0014] The materials according to the invention have proved out to be surprisingly strong and tough in a manner that they can be used in manufacturing various surgical implants to connect tissues or parts thereof to each other, to separate tissues or parts thereof from each other, to temporarily replace tissues and/or to guide healing or growth of tissues. Implants of this type include e.g. various rods, screws, pins, hooks, intramedullary nails, plates, bolts, suture anchors. toils, wires, tubes, stents, spirals or implants of a corresponding type, presented e.g. in publications U.S. Pat. No. 4,743,257, FI Pat. No. 81010, U.S. Pat. No. 4,968,317, FI Pat. No. 84137, FI Pat. No. 85223, FI Pat. No. 82805, PCT/FI 93/00014 and PCT/FI 93/00015, U.S. Pat. No. 5,084,051, U.S. Pat. No. 5,059,211, FI Pat. No. 88111 and EP-634152.
[0015] The materials of the invention can be manufactured of thermoplastic, amorphous biodegradable polymers, such as L-lactide copolymers containing a large quantity of D-lactide units (e.g. poly L/DL-lactides having 15 to 85 molecular-% of D-units), amorphous copolymers of lactide and glycol, as well as polymer combinations forming amorphous alloys. It is self-evident that the materials of the invention can be manufactured also from other amorphous, biodegradable polymers, like e.g. of polyorthoesters, (see e.g. U.S. Pat. No. 4,304,767), of pseudopoly (amino acids) (see e.g. S. I. Ertel et al., J. Biomed.Mater. Res., 29 (1995) pp. 1337-1378), etc.
[0016] Further, materials in accordance with the invention can include as compound agent powder-like ceramic or corresponding materials. such as bone meal, hydroxyl-apatite powder, calcium-phosphate powder and other absorbable ceramic powders or absorbable ceramic fibres, like bioglass fibres.
[0017] According to one advantageous embodiment, the material of the invention also contains at least one organic or inorganic bioactive agent or agents, such as antibiotics, chemotherapeutic agents, agents activating the healing of wounds (e.g. angiogenic growth factors), bone growth factors (bone morphogenic proteins [BMP]) etc. Such bioactive materials are particularly advantageous in clinical use, since, in addition to mechanical effect, they also have biochemical, medical and other effects for tissue healing.
[0018] It is obvious that the materials of the invention can also include various additives for facilitating processing of the material (e.g. stabilizers, antioxidants or softeners) or for altering its properties (e.g. softeners or powder-like ceramic materials or biostable fibres, such as polyaramid or carbon fibres) or for facilitating its handling (e.g. colorants).
[0019] The accompanying dependent claims present some advantageous embodiments of the material according to the invention.
[0020] The invention also relates to a method for manufacturing under tissue conditions absorbable material. The method is mainly characterized by features presented in the characterizing part of the accompanying independent claim relating to the method.
[0021] Advantageous embodiments of the method are presented in the accompanying independent claims.
[0022] When manufacturing materials in accordance with the invention, a molecular orientation is carried out by modifying biomaterial in solid state mechanically in a temperature where large scale molecular movements are possible, but where thermal movement is not strong enough for the achieved orientation to relax as a result from the molecular thermal movements.
[0023] The simplest way of performing the mechanical modification is to draw a melt-processed (such as injection molded, extrusion molded or compression molded), non-oriented billet or preform (such as a rod, plate or film) to a typical drawing ratio of 2 to 6 in the direction of the longitudinal axis of the billet. The drawing can also be carried out as a so called die drawing, wherein the billet is drawn through a heated die to a suitable drawing ratio. As a result of the drawing, the molecule chains and/or parts thereof are directed increasingly to the draw direction, wherein the strength and toughness of the material are growing in the draw direction. After the drawing, the drawn billet is cooled under stress to room temperature, and various implants can be further processed thereof, such as rods, screws, plates, pins, hooks, stents, spirals etc. Suitable processing methods are e.g. turning, milling, shearing and other mechanical processing methods, thermal processing (compression molding under heat and pressure) or combinations of mechanical processing and thermal processing.
[0024] During drawing, the billet or die can also be turned around the longitudinal axis of the billet, wherein a spiral orientation is obtained thereto, which is particularly advantageous e.g. in screws.
[0025] For plate-formed and foil-like preforms, also two-axial drawing can be carried out, wherein orientation is obtained for the billet also in a direction perpendicular to its longitudinal axis.
[0026] Materials of the invention can be manufactured of said raw materials also by using so-called solvent methods, wherein at least a part of the polymer is solved into a suitable solvent or softened by the solvent and the material or the material combination is compresses to a piece by using pressure and possibly a slight heat, wherein the solved or softened polymer glues the material to a macroscopic piece, from which the solvent is eliminated by evaporating. Techniques of this type are suitable particularly when manufacturing thermosensitive enzymes, peptides and proteins, such as implants containing BMP-molecules.
[0027] In the following specification, the invention is illustrated with reference to the Examples and the accompanying drawings. In the drawings
[0028]FIG. 1. shows test results in drawing ratio—shear strength—co-ordination according to Example 1,
[0029]FIG. 2 shows test results in test speed—tensile break energy—coordination according to Example 1,
[0030]FIG. 3 shows from two directions the installation of intramedullary nails in connection with osteolomy in a femur according to Example 3,
[0031]FIG. 4 shows from the side (4 a) and from the front (4 b) the manufacturing of material billet according to Example 8, and
[0032]FIG. 5 shows a perspective view of a prostate spiral manufactured of a billet according to FIG. 4.
[0033] Cylindrical billets having a diameter of 2, 3, 4 and 5 mm were manufactured of poly-L/DL-lactide (L/DL mole ratio 70/30, incl. viscose 5.8 dl/g, trade name Resomer� LR 708, manufacturer Boehringer Ingelheim, Germany) by extrusion (1-screw extruder), which billets were cooled to room temperature.
[0034] Shear strength was measured according to a method presented in the publication P. Tormala et al.: "Ultra-high rigidity absorbable self-reinforced polyglycolide (SR-PGA) composite rods for internal fixation of bone fractures": In vitro and in vivo study" J. Biomed. Mat. Res., 25 (1991), pp. 1-22 to a billet having a diameter (�) of 2 mm. The obtained shear strength value was 50�4 MPa.
[0035] Billets of various sizes were drawn at various temperatures to various drawing ratios (to rods of 0 2 mm) for obtaining at least a partial molecular orientation and for improving the shear strength of the material. The shear strengths of rods oriented and reinforced by drawing are presented in FIG. 1. According to FIG. 1, even with a drawing ratio 2 the shear strength of the rod has increased to 1.5-fold (to a value of 73 MPa) as compared to a non-drawn rod. With drawing ratios 3 to 5. shear strengths of 110 to 118 MPa are obtained, which values are already in the same area as the values measured for partially crystalline, drawn polylactide rods (cf. e.g. S. Vainionp{umlaut over (aa)} et al.: Surgical applications of biodegradable polymers in human tissues", Prog. Polym. Sci. 14, (1989). pp. 679-716).
[0036] Bending impact toughness of a non-drawn P(L/DL)LA (70/3) rod and a rod of the same material drawn to a drawing ratio 5 at a temperature of 70� C. were tested at a room temperature by defining the bending impact energy (J/mm2) of the rods (both having a diameter of 2 mm) by a three-point bending impact machine. The bending impact energy required for breaking the non-drawn rod was 0.017 j/mm2 and the rod was broken in a brittle manner. The drawn rod did not break at all, but it bent in a ductile manner and glided through the supports of the measuring equipment when the bending impact energy value was 0.093 j/mm2
[0037] Thus, as a result of the drawing reinforcement, the bending behaviour of the amorphous Resomer� LR 708 polymer in impact stress changed from brittle to ductile and the endurance of the bending impact of the material increased more than five fold.
[0038] Corresponding break toughness tests were made to a non-drawn and drawn P(L/DL)LA (70/30) rods (� 2 mm) (drawing ratio about 5, draw temperature 75� C.) at a room temperature by measuring the energy needed for breaking the rod in a drawing test as a function of the testing speed (%/min.). The results are shown in FIG. 2. According to FIG. 2, the tensile break energy of non-drawn rods is between 0.2 to 0.7 J/mm2 whereas the tensile break energy of drawn rods was between 1.8 and 3 J/mm 2. Depending on the test conditions, the tensile break energy of the material thus increased to 2.5 fold (slow draw)—15 fold (impact draw) as a result of the draw reinforcing.
[0039] Drawn (self-reinforced) P(L/DL)LA (70/30) rods (length 30 to 50 mm, thickness 2 mm) according to Example I were dried in a vacuum at a temperature of 37� C. for several days. The rods were packed in A1-foil bags and sterilized with y-radiation (dose 2.5 Mrad.)
[0040] Clinical research, corresponding to the research of K. E. Rehm et al.: "Bericht der Arbeftsgruppe Biodegradable Implantaten", Akt. Traumatol 24, (1994), pp. 70-74, was performed relating to the use of drawn, γ-sterilized, self-reinforced SR-PLA rods (L/DL ratio 70/30) for fixation of fractures in cancellous bone area. Table I contains comparison between indication groups of the Rehm et al. research (using non-oriented, reinforced P(L/DL)LA (70/30) rods, � 2 mm) and indication groups of the accompanying clinical research (using oriented and self-reinforced P(L/DL)LA (70/30) rods; Biofix� SR-PLA. � 2 mm). In the clinical research of the rods according to the invention, attempts were made to reach as good correspondence as possible with the research of Rehm et al.
[0041] Table 1 shows that with non-reinforced Polypin� rods, there were more than a six-fold quantity of complications compared to clinical use of the self-reinforced Biofix� SR-PLA rods, having only one fracture dislocation (a severe fracture of radius head). Since the material used in both tests was chemically the same and the rods had the same diameter (2 mm), it is obvious that the shear strength of the self-reinforced Biofix(� SR-PLA rods in accordance with the invention was more than twice as high (>100 MPa) as compared to the shear strength of Polypin� type material (about 50 MPa), which makes the Biofix� SR-PLA rods more suitable for clinical use.
[0042] Bar with thickness of 3 mm was manufactured of PDLLA polymer (L/D molecular ratio of 50/50), incl. viscosity 5.2 dl/g, trade name Purasorb(� PLD, manufacturer PURAC Biochem, Holland) by melt processing with 1-screw extruder, which bar was then cooled to room temperature. The bar was drawn at a temperature of 60� C. to the drawing ratios of 3.3 and 5.5. The shear strengths of non-drawn and drawn bars were measured (Table 2).
[0043] According to Table 2, the shear strength of the amorphous PDLLA increased almost to double when the material was drawn to a drawing ratio 5.5.
[0044] Non-drawn (non-reinforced) SR-PDLLA rods and corresponding drawn rods (self-reinforced) drawn to a drawing ratio of 5.5 were manufactured. The length of the rods was 50 to 60 mm, and the diameter was 4.5 mm.
[0045] 20 adult rabbits were killed and the right femora were taken to biomechanical research. Holes of 4.5 mm were drilled to the intramedullary canal from the intercondylar area and the intramedullary canals were expanded with a rasp to the diameter of 4.5 mm. Osteotomy was made by a rotating diamond drill in the distal third of the diaphysis area in the femora. The osteotomy was fixated by using either a non-reinforced 4.5�(50-60) mm rod or a self-reinforced 4.5�(50-60) mm rod as the intramedullary nail (FIG. 3). Bending rigidities of the sheared femora nailed with intramedullary nails were measured by using a 3-point bending test. The femora having self-reinforced rods as intramedullaty nails had circa twice as good bending rigidities compared to femora having non-reinforced rods. On the basis of these results it was concluded that self-reinforced SR-PDLLA rods are more suitable for intramedullary nails of bone fractures than non-reinforced ones.
[0046] SR-PLA rods in accordance with Example 2 were manufactured (drawing ratio 5.5, rod length 70 to 200 mm, diameter 2 mm), which rods were y-sterilized (radiation dose=2.5 Mrad).
[0047] The rods were used as intramedullary nails for fixation of fractures of cortical area in radii of ten children (ages 2 to 7 years), by using "stack pinning" technique (two or more rods were used for filling the intramedullary canal). After the nailing, a plaster immobilisation was used for six weeks.
[0048] All the ten fractures provided with intramedullary nails healed well or in a satisfactory manner.
[0049] According to Example 1, self-reinforced P(L/DL)LA (70/30) rods (drawing ratio=5) having a thickness of 2 mm, as well as non-reinforced rods of the corresponding size, were manufactured.
[0050] The rods were γ-sterilized (radiation dose=2.5 Mrad) and hydrolyzed in phosphate buffer solution (pH 7.4) at 37� C. for 40 weeks. After 20 weeks of hydrolysis, the bending strength of the self-reinforced rods was still the same as at the starting point (170�10 MPa), whereas the non-oriented rods had lost more than a half of their original strength (original bending strength 120 MPa, after 20 weeks of hydrolysis: 55 MPa).
[0051] The half-life of rigidity in said hydrolysis was 32 weeks with self-reinforced rods and only 19 weeks with non-reinforced rods.
[0052] The above mentioned tests showed that self-reinforcing of the amorphous material makes it more durable against y-sterilisation than nonreinforced material, even to the extent that reinforced rods can be y-sterilized for clinical use. This is a significant advantage for the patients, since in the alternative ethylene-oxide sterilisation harmful residues of ethylene oxide may be left in the material.
[0053] In accordance with Example 1, self-reinforced rods (diameter 2.5 mm, length 70 mm) were manufactured of extruded P(L/DL)LA (70/30) billet (diameter 5 mm) by drawing to the drawing ratio 4 at a temperature of 60 to 90� C. Plates having a thickness of 0.5 mm (width 10 mm, length 70 mm) were manufactured of draw-reinforced rods between heated steel plates by compression molding at a temperature of 60 to 90� C. Non-reinforced plates of the corresponding size were manufactured by extrusion (1-screw extruder) by using a flat-foil die.
[0054] The mechanical properties of the non-drawn and draw-reinforced and compressed plates were examined by draw and shear tests at a room temperature. The effect of drill holes to the rigidity of the plates was examined by drilling 6 holes (� 2.0 mm) in a part of the plates. Table 3 shows strength values of a plate drawn at 70� C. and compression molded at 90� C., as compared to a non-reinforced plate.
[0055] According to Table 3, the drilling of holes deteriorated the tensile strength of the plates by 18%, but it did not have significant effect on the shear strength. Even after the drilling of holes, the strengths of the self-reinforced plates were 1.8 to 2.3 fold as compared to non-reinforced plates.
[0056] Self-reinforced (drawn) P(L/DL)LA (70/30) rods (length 35 mm) of Example 5 were implanted in the muscular tissue in the back of 20 adult rabbits. The rabbits were divided into four groups and after they were killed, biodegradation of the self-reinforced rods were examined under tissue conditions by histological methods after six months, one, two and three years from implantation. Six months after the implantation the shapes of the rods were almost unaltered, although two rods were broken into two or three pieces, presumably as an effect of muscular movement. One year after the implantation all the rods were broken into pieces. Two years after the implantation, the material was almost entirely absorbed; only some occasional polymer particles could be found in the muscular tissue. Three years after the implantation the polymer was entirely absorbed and disappeared from the tissues.
[0057] To provide comparison material, a corresponding series of test was carried out by implanting in the muscular tissue of the rabbits partially crystalline, self-reinforced poly-L-lactide rods (manufacturer of the material: PURAC Biochem, Holland, Mw=250 000) which were manufactured by self-reinforcing technique (drawing technique) (according to the method of the publication P. T�rm�l�: "Biodegradable self-reinforced composite materials: manufacturing, structure and mechanical properties, Clinical Materials", 10 (1992), pp. 29-34). The thickness of the rods was 2 mm and the length was 35 mm. In histological research it was noted that six months and one year after the implantation the rods were still unaltered. Two years after the implantation the rods were broken into several pieces and partially disintegrated. Three years after the implantation there were still a large quantity of disintegrated poly-L-lactide material (debris) to be found in the muscular tissue.
[0058] The present research proved that amorphous, self-reinforced implants in accordance with the invention absorb in tissues considerably faster than corresponding, partially crystalline, self-reinforced materials.
[0059] Oriented billet of diameter 1.1 mm was manufactured of P(L/D)LA (70/30) material by draw-reinforcing technique, by drawing a blank having a diameter of 2 mm slowly through heated (T ˜80� C. ) rollers in a manner shown in FIG. 4a. As shown in FIG., 4 b, the surfaces of the rollers comprised grooves, which together formed a channel of 1.1 mm diameter between the rollers.
[0060] Prostate stents (spirals) according to FIG. 5 were manufactured of drawn billet in accordance with technique presented in publication WO .90/04982, to be used to eliminate urethral retention in the prostate area, after laser treatment for benign prostatic hyperplasia. Lengths of the cylindrical part of the stents were 55, 65, and 75 mm and the total lengths were about 80 to 100 mm.
[0061] A stent according to the invention was inserted in ten patients after laser treatment (VLAP-laserprostatectomy) for prostatic hyperplasia, according to the publication M. Talja et al.: "Biodegradable SR-PGA-urospiral in prevention of postoperative urinary retention after VLAP-laser prostatectomy", J Urol. (in press).
[0062] When using a prostate spiral according to the invention, there was no deteriorating of urine-flow velocity to been seen in the patients during the healing; the follow-up term was 12 months. The prostate spirals absorbed and left the urethra in a period of 3 to 9 months (found on the basis of endoscopical research).
[0063] According to the above mentioned publication M. Talja et al., when self-reinforced, partially crystalline polyglycolide (SR-PGA) prostate spirals were used as post-treatment of laser treatment for benign prostatic hyperplasia, in ten patients out of 22 deteriorated urine-flow velocity occurred temporarily about three weeks after the insertion of the spiral. This was presumably due to the absorbing of the spiral three to four weeks after the implantation.
[0064] This comparative clinical research showed that the SR-PLA spirals in accordance with the invention provided better treatment results in post-laser treatment for benign prostatic hyperplasia than prior art, partially crystalline, self-reinforced spirals.
[0065] According to Example 1, self-reinforced P(L/DL)LA (70/30) rods having a thickness of 2 mm (drawing ratio=5), as well as non-reinforced rods of the corresponding size were manufactured. The lengths of the rods were 20 Mm. Both in self-reinforced and non-reinforced rods was made, by turning at one end for the length of 10 mm, a screw thread, having the minimum diameter of 1.5 mm, the maximum diameter of 1.8 mm and the distance of 0.8 mm between the peaks of the threads. The threaded rods were sharpened at their tops.
[0066] 10 mm deep holes were drilled in the distal part of a cow femur in the cancellous bone area by using a 1,1 mm bone drill. Holes were threaded with a tapping device, having the same profile as the above mentioned, threaded rod parts. The threaded rods were screwed in the holes, made in the bones and having a thread profile, by fixating the rods at their smooth part in the socket of the drilling machine and by screwing the screw thread parts of the rods into the holes. Draw-out force of both self-reinforced and non-reinforced threaded rods were measured by fixating the socket of the drilling machine to a mechanical testing device and by drawing the threaded rod out of the bone. A relative draw-out force was determined to the self-reinforced rods in a following manner:
[0067] By measuring the draw-out forces to five self-reinforced and five non-reinforced threaded rods, an average of 1.4 was obtained for the relative draw-out force of self-reinforced, threaded rods. A screw-threaded rod of self-reinforced material implanted in the bone was thus significantly better compared to an implant of non-reinforced material.
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1000+ Rentals · Woluwe-Saint-Lambert
1000+ Rentals · Woluwe-Saint-Lambert
Chambre de 12m2 a louer dans grand appartement de 90m2 a 10min à pied du site universitaire d'Alma. Séjour de 30m2, cuisine super équipée, salle de bain avec douche et bain. WC séparé. Coloc avec un couple, un chien et un chat :)
Hi all, Welcome to the heart of Europe. I have a nice, quiet and well-equipped studio for 2 or 3 ppl. Located in campus and nearby to the metro Alma station-line 1 which can take directly to most attractions. The studio is private and security. Learn More
the studio is located in one of the oldest university with beautiful view, convenience to travel most of attraction in Brussels, and here is very security.
Woluwe-Saint-Lambert, Woluwé-Saint-Lambert
Situé à Woluwe Saint Lambert, 4 chambres d'étudiante de 15m2 avec un énorme commu lumineux de 40m2. Propre et proche des commerce, à 600 mètre du métro Roodebeek (10min du centre)
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The apartment is located on the most residential street of Brussels. The building has 4 floors and the apartment is located at 1st floor. The kitchen has everything you need to make breakfast, lunch, dinner. There is a practical showerroom as well a seperate toilet. 5 min walk to metro station Josephine Charlotte or Gribaumont 10 min to European Commission(Schuman metro) 25 minutes from Zaventem airport You will have your own keys so you are free to come and go at any time. Everything i...
Woluwe-Saint-Lambert, Woluwé-Saint-Lambert
Modern 2 bedrooms apartment in Brussels - Woluwe-Saint-Lambert. 50m from metro Roodebeek Station - 5 min walking distance from Woluwe Shopping Center - Bus airport 2 min walking distance Private parking - Terrace High speed internet WIFI cable TV Learn More
Woluwe-Saint-Lambert, Woluwé-Saint-Lambert
- the building is situated in a private park - living room with a double bed and a sofa bed - bathroom - kitchen - a big terasse of 7,5m² - a private parking lot - metro - 6 mi Learn More
- the building is situated in a private park - living room with a double bed and a sofa bed - bathroom - kitchen - a big terasse of 7,5m² - a private parking lot - metro&bus station Roodebeek - motorway E40 - metro - 6 min to EU quarter - metro - 10 min to the center
Woluwe-Saint-Lambert, Woluwé-Saint-Lambert
Modernity Central location Access to public transport tram subway bus close to Zaventem airport Email phone wifi Fully equipped kitchen terrace Laundry room with washing machine Iron Hair dryer
Woluwe-Saint-Lambert, Woluwé-Saint-Lambert
Large furnished studio fully refurbished 2 minuts walk from the subway! Learn More
Large furnished studio fully refurbished with a large entrance with dressing room, bathroom with shower and washbasin, separate toilet, fuly equipped kitchen (oven,fridge,freezer,,dishwasher,microwave,senséo...), living room with double bed,desk,living room, TV,internet.Vieuw panoramique. Double vitrage. Excellent situation:beautiful areas of Brussels, 2 minuts walk from the subway Tomberg!Many shops around including a Carrefour. Deposit 300 euro.
Stylish, quite, modern, bright, luxury, fully fitted, loft style/open plan, three bedroom Penthouse located in quite, safe area with free private parking. It's 15 mins door-to-door (via direct metro) to city centre and European Institutions. Learn More
The 140 sq meters apartment is not overlooked and surrounded by a 175 sq meters East, South & West facing terrace. The Master double bedroom has a fully integrated en-suite with double shower. The second twin or double bedroom (please specify) has a separate en-suite with double triangular bath and shower over. There is a separate bedroom with skylight and a comfortable single IKEA bed/seat. The Roodebeek Metro and Bus station are all 200m walk from where there is a direct Metro line ...
Grd appartement (110m2) très lumineux situé dans un des plus beaux quartiers de Bruxelles (Woluwé St Lambert). 3 chambres, 6 personnes. Appartement 3 ch avec terrasse, grand living room lumineux (tv, dvd, wifi), cuisine équipée, salle de bain/douche avec machine à laver. accueil de 6 personnes ch1 (2 pers): 2 lits simples; ch2 (2 pers): 1 lit superposé; ch3 (2 pers): 1 lit double (possibilité de 2 lits simples). A titre exceptionnel, possibilité d'utiliser canapé lit 2 personnes dans living ...
The main spirit is accessibility. Parc du Cinquantenaire and it's museum is next door and the area is central in terms of public transportation. Montgomery metro station less than 2 min walk. Handy shopping street - rue des Tongres - 3 min on foot. Learn More
Full equipped apartment at ground floor of a classic Brussels house with all modern comfort. New beddings fort perfect sleep comfort in a very quiet neighbourhood. Covered terrace with table and chairs. The fully equipped apartment is all yours with a capacity for 4 people as well as a little bed for a baby. All appliance available for people looking for extended stay. I respect my guests' privacy and would only interact with them if they wish to, or need specific information. The street...
Woluwe-Saint-Lambert, Brussels
Little nice and cosy room in a two bedrooms apartment with small garden, situated close to bus stop and 15 minutes walk to metro stop. Shared kitchen, bathroom Learn More
Woluwe-Saint-Lambert, Woluwé-Saint-Lambert
We will make your stay a good remembering, enjoying the house, our services and Brussels. This B&B is located in a big house in the north-east of Brussels in a quiet area, close to NATO, near Brussels ring road and Brussels national airport (Zaventem). You will be taken care of by a nice family in either French, Dutch, Spanish or English. Weather permitting; you will be able to take advantage of a beautiful garden tastefully tended by the lady of the house. An ideal place for a longer stay....
Woluwé St Lambert. 5 km east of Brussels. Just near métro "Roodebeek". Shopping Center, 200 m. Cultural Centrum "Wolubilis" and "book and look" 200m. Private parking free. bus for aeroport Brussels ( n° 353 and 653)every 15 minutes at 200m. Learn More
Private parking free. My appart. has a terrace (nerrow and long). It is a quiet city. You have all my appartement. You have metro just near my appartment, to go in centrum fo Brussels. at 200 m you have a parking where stop many bus: direction airport of Brussels (n° 353 and 653 ) every 15 '. Or "cbis" to go to "Louvain la Neuve "( University). Or other bus to go to Brussels.
Woluwe-Saint-Lambert, Bruxelles
Appartement moderne et spacieux situé à deux pas de Montgomery. Cet appartement est constitué de trois chambres, un séjour de 45m2 ouvert sur la cuisine entièrement équipée. Une salle de bain avec douche italienne et ainsi que des toilettes séparées.
Woluwe-Saint-Lambert, Woluwé-Saint-Lambert
Hello We would be happy to host you in our apartment located 300 meters from Metro and Bus Station Roodebeek It takes 15 min. to go to the city by metro, 15 min. to the airport by car (also possible to go by bus, about 30 min. and 2€ ticket). Learn More
Hello We would be happy to host you in our apartment located 200 meters from Metro and Bus Station Roodebeek It takes 15 min. to go to the city by metro, 15 min. to the airport by car (also possible to go by bus, about 30 min. and 2€ ticket). The apartment is 110m² beautifully located in a very nice and quiet neighborhood but still very central and near parks, and also at a walking distance from Woluwe Shopping Centre (200m). Availability of washing machine (extra), tv, wifi, bathroom, 1 r...
Bright flat with sunny terrace! Walking distance from the UE bubble. Great green public parc round the corner. Living room, kitchen, sleeping and bath room Internet Métro station and bus lines down the street Bed and bath sheets at disposal Learn More
Bright and handy flat. The sun shines on the terrace all day ... ideal for a pleasant breakfast or meal! Pleasant and clean neighbourhood with a lot of restaurants, take away food and a public parc round the corner to chillout after a busy sightseeing or work day. All facilities within walking distance: shops, subway station down the street, free car park possibilities. (Bed) Sheet, bad sheet and towels at disposal for free. The travellers will have the whole apartement at disposal. T...
Woluwe-Saint-Lambert, Woluwé-Saint-Lambert
In the heart of the European Institutions area, just off Montgomery square. This beautiful 80 square meters is very cosy, clean and modern. It is situated in one of the best and safest neighborhoods in Brussels. It is very convenient for a weekend. Learn More
Full equipped 80 square m apartment at ground floor of a classic Brussels residence with all modern comfort. Situated in one of the best and safest neighborhoods in Brussels. It is very convenient for a weekend visit or for professionals working at the very nearby European institutions. The fully equipped apartment is all yours with a capacity for 2 people. All appliance available for people looking for extended stay. The apartment is situated in a wonderful, safe neighbourhood with beaut...
Woluwe-Saint-Lambert, Woluwé-Saint-Lambert
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