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Upstate News
Darryl Geddes 315 464-4828
University Hospital executive earns top healthcare management credential
SYRACUSE, N.Y. — Manlius resident Paul E. Seale, chief operating officer of University Hospital, has been named a Fellow of the American College of Healthcare Executives (ACHE). A Fellow is one of the highest honors offered by ACHE, the nation's leading professional society.
Fellow status is reserved only for the top performing healthcare executive in the nation. In order to receive Fellow status, individuals must pass a comprehensive examination, meet academic and experiential criteria, earn continuing education credits and demonstrate ongoing community and professional involvement. Fellows must undertake a rigorous professional development program and undergo recertification every three years.
"Healthcare management affects people in our communities which is why it is critically important to have a standard of excellence promoted by a professional organization," said Thomas C. Dolan, Ph.D., president and chief executive officer of ACHE. "By becoming an ACHE Fellow and simultaneously earning board certification from ACHE, healthcare leaders show that they are committed to providing high-quality service to their patients and community."
Prior to joining University Hospital in 2006, Seale served as president and chief executive officer of New Island Hospital in Bethpage, N.Y., and chief operating officer of Stony Brook (N.Y.) University Hospital Medical Center.
University Hospital is the teaching hospital of SUNY Upstate Medical University.
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Hotels in 20621 - Chaptico MD
Only hotels in 20621 zip code are listed below. Search for cheap and discount hotel rates in Chaptico, MD for your upcoming leisure or conference / group travel. We list the best 20621 hotels and motels so you can review the Chaptico hotel list below to find the perfect lodging. Hotels in Saint Marys county and area code 301 are also listed.
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Clothing/Shoes/Weather Gear: Good shoes are essential for caves (slippery!) & jungle. Shorts and T-shirts go almost anywhere, but take also trousers and long-sleeved shirt to cover your skin against the mosquitos at night.
Toiletries and Medical Supplies: Mosquito repellent!!! There is a small risk of malaria in Kanchanaburi province, so be prepared! However, medication against malaria is not recommended for short trips (side-effects), so repellent and clothing are the best ways to avoid the risk.
Miscellaneous: You might want to take a flashlight for the caves - it is also very useful at the River Kwai Jungle Rafts at night!
- Adventure Travel
- Jungle and Rain Forest
Luggage and bags: During the day you may need a small backpack but do without if you can...it's too hot & humid to be carrying something on your back all day... It could be easier just to carry a bottle of water and some cash...
Clothing/Shoes/Weather Gear: Take good walking shoes because you will be bound to come across uneven surfaces and you'll do a lot of walking around the area.
Toiletries and Medical Supplies: We were advised to take malaria tablets by our doctor...although we didn't see too many mozzies we both got bitten.
Photo Equipment: Take HEAPS of film or memory cards...you'll need them...especially if you go to the Tiger Temple or for an elephant ride... ;)
- Food and Dining
Jungle Survival
Luggage and bags: Aside from your clothes bag, bring a small knapsack or sling bag to carry a bottle of water, your camera and a small towel or shirt when you go treking around the caves or waterfalls.
Clothing/Shoes/Weather Gear: Bring INSECT REPELLANT!! Leave the high heels and leather shoes at home, no fancy bars or rave parties here. Just lots of trekking, kayaking and other nature outdoor stuff. Do bring a hat, shades, sunblock, swimsuit, slippers and a nice pair of hiking boots or mojos. A foldable raincoat would be nice too.
Toiletries and Medical Supplies: Basic first aid kit and whatever medication you regularly take. No hospital, pharmacy or infirmary nearby. Bring you basic toiletries, shampoo, soap, toothpaste, toothbrush etc, Jungle Rafts Resort only provides soap.
Photo Equipment: Camera and video cam! Lots of film! Splash pack if you have one.
Camping/Beach/Outdoor Gear: Nice handy flashlight especially when your resort has no electricity. good for cave trekking too.
Miscellaneous: If you have a sweet tooth or need to have a snack between meals, come prepared and bring your rations so you wont go hungry. Chips, chocolate, candy, cake, brownies, ..pack em in less you go crazy without them.
- Rafting
- Fishing
- Hiking and Walking
What to bring for 3-day trip?
Luggage and bags: Your own backpack is good enough. Some people may take only a few cloths and leave thier luggage behind in Bangkok. This is not necessary as the minivan/tour guides will make good arrangement for you so that you don't need to carry your stuff while trekking. This allows you to have adequate supply of everything. After all, if you only need a few clothes for 3 days trip, then why do you carry the whole backpack (10-15 kgs?) in the first place?
Clothing/Shoes/Weather Gear: Common sense stuff
- Budget Travel
Luggage and bags: When out and about I carry a small backpack. This carries all my daily neccesities . There are a few but they are very light and what I deem neccesary items. This also carries all my camera equipment that is "out of sight"
There are two most important items that I always have with me and they are:
Sufficent fresh bottled water ...more than enough for the heat of the tropical days.
A good reliable Mosquito and insect repellant. People always ask if I think this is neccesary??? In the tropics Malaria and Dengue fever are prevelant and I am NEVER without my mosquito and insect Repellant.
Clothing/Shoes/Weather Gear: Walking over great distances is the norm when travelling so I always wear,
A good hat for sun protection.
A pair of reliable sunglasses for sun protection also.
A strong and comfortable pair of hiking/walking boots/shoes .
Toiletries and Medical Supplies: Whenever I am travelling in the tropics and due to the extreme heat and humidity I always carry these items:
A small tube of sunscreen 15+
A small packet of wet ones...not only for heat but also for wiping small injuries clean.
A small tube of lip balm
A small tube of moisturiser
A small packet of tissues in case the roll is empty!!
A small bottle of hand sanitiser...so much food is hand eaten..
A couple of band aid strips...always handy to have in your pocket.
Photo Equipment: I really like my photography and carry digital cameras and lenses.
A battery charger for my digital batteries
An International power point adaptor.. imperative...
A spare memory card to avoid any dissapointment.
Camping/Beach/Outdoor Gear: A small rolled up poncho..This covers me and my back/pack in case of tropical storms.
A small self winding torch ..this is a must.
Miscellaneous: This may seem like a lot of items but they are all small, light , and I feel neccesary for me to carry.
- National/State Park
- Photography
- Hiking and Walking
- 1
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An endoluminal support structure includes strut members interconnected by swivel joints to form a series of linked scissor mechanisms. The structure can be remotely actuated to compress or expand its shape by adjusting the scissor joints within a range of motion. In particular, the support structure can be repositioned within the body lumen or retrieved from the lumen. The support structure can be employed to introduce and support a prosthetic valve within a body lumen.
1. A medical device configured for passage through a biological lumen of a patient, comprising:
a plurality of strut members, comprising:
discrete elongated inner strut members; and
discrete elongated outer strut members interlinked to the plurality of elongated inner strut members by a plurality of swivel joints to form a shaped structure comprising a compressed orientation and an expanded orientation;
wherein each inner strut member is interlinked with at least three outer strut members and none of the inner strut members are interlinked to another inner strut member; and
wherein each outer strut member is interlinked with at least three inner strut members and none of the outer strut members is interlinked to another outer strut member, and wherein at each swivel joint, the inner strut members are located closer to a central axis of the apparatus than the outer strut members.
2. The apparatus of
3. The apparatus of
4. The apparatus of
5. The apparatus of
6. The apparatus of
a first structural member coupled to the plurality of strut members;
a second structural member rotatable relative to the first structural member; and
a plurality of pliable valve members connecting the first structural member with the second structural member such that rotation of the second structural member relative to the first structural member urges the valve members between an open and a closed state.
7. The apparatus of
8. The apparatus of
9. The apparatus of
10. The apparatus of
11. A medical stent, comprising:
a plurality of elongated strut members, including inner strut members and outer strut members; and
articulations connecting the inner strut members and the outer strut members such that:
each inner strut member comprises articulations with three outer strut members;
none of the inner strut members comprises articulations with another inner strut member;
each outer strut member comprises articulations with three inner strut members; and
none of the outer strut members comprises articulations with another outer strut member, and wherein at each articulation, when the stent is at a maximally expanded orientation, the inner strut members are located closer to a central axis of the stent than the outer strut members.
12. The stent of
13. The stent of
14. The stent of
15. The stent of
16. The stent of
17. The stent of
18. The stent of
19. The stent of
a first structural member coupled to the plurality of strut members;
a second structural member rotatable relative to the first structural member; and
a plurality of pliable valve members connecting the first structural member with the second structural member such that rotation of the second structural member relative to the first structural member urges the valve members between an open and a closed state.
20. The stent of
21. The stent of
22. The stent of
23. The stent of
24. The stent of
25. The stent of
26. The stent of
This application is a continuation of PCT Application No. PCT/US2009/051324, filed on Jul. 21, 2009, which claims the benefit of U.S. Provisional Application No. 61/082,489, filed on Jul. 21, 2008, both of which are hereby incorporated by reference in their entirety.
Endoluminal stents can be implanted in a vessel or tract of a patient to help maintain an open lumen. The stents can also be used as a frame to support a prosthetic device or to deliver a therapeutic agent. Stents can be implanted by either an open operative procedure or a closed operative procedure. When an option exists, the less invasive closed procedure is generally preferred because the stent can be guided through a body lumen, such as the femoral artery, to its desired location.
Closed procedures typically use one of two techniques. One closed procedure employs balloon catheterization where an expandable stent encloses an inflatable balloon. In this procedure, the stent is implanted by inflating the balloon, which causes the stent to expand. The actual positioning of the stent cannot be determined until after the balloon is deflated and, if there is a misplacement of the stent, the process cannot be reversed to reposition the stent.
The other closed procedure employs a compressed stent enclosed by a removable sheath. In this procedure, a stent made from a shape memory alloy, such as Nitinol, is held in a compressed state by a sheath. The stent is implanted by withdrawing the sheath, causing the stent to expand to its nominal shape. Again, if there is a misplacement of the stent, the process cannot be reversed to reposition the stent.
Positioning errors are particularly dangerous when the stent is used to support a cardiac valve. Serious complications and patient deaths have occurred due to malpositioning of the valve at the implant site in the body, using the available stent-mounted valves. Malpositioning of the valve has resulted in massive paravalvular leakage, device migration, and coronary artery obstruction. The majority of these complications were unavoidable, but detected at the time of the procedure. However, due to inability to reposition or retrieve the device, these problems were impossible to reverse or mitigate during the procedure.
An endoluminal support structure or stent in accordance with certain embodiments of the invention solves certain deficiencies found in the prior art. In particular, the support structure can be repositioned within the body lumen or retrieved from the lumen.
A particular embodiment of the invention includes a support apparatus implantable within a biological lumen. The support apparatus can include a plurality of elongated strut members interlinked by a plurality of swivel joints, wherein the swivel joints can cooperate with the stent members to adjustably define a shaped structure between a compressed orientation and an expanded orientation.
More particularly, the shaped structure can be one of a cylindrical, a conical, or an hourglass shape. A swivel joint can form a scissor mechanism with a first strut member and a second strut member. Furthermore, the strut members can be arranged as a series of linked scissor mechanisms. The apparatus can further include an actuation mechanism to urge the swivel joints within a range of motion.
The apparatus can also include a prosthetic valve coupled to the shaped structure.
Another particular embodiment of the invention can include a medical stent implantable within a biological lumen. The medical stent can include a plurality of elongated strut members, including a first strut member and a second strut member, and a swivel joint connecting the first strut member and the second strut member.
In particular, the swivel joint can form a scissor mechanism with the first strut member and the second strut member. The swivel joint can bisect the first strut member and the second strut member. The swivel joint can interconnect a first end of the first strut member with a first end of the second strut member.
The plurality of strut members can be arranged as a series of linked scissor mechanisms. The strut members can also be non-linear. The strut members can be arranged to form one of a cylindrical, a conical, or an hourglass shape.
The stent can further include an adjustment mechanism to exerting a force to urge the strut members about the swivel joint within a range of motion.
The stent can include a prosthetic valve coupled to the strut members.
Specific embodiments of the invention can include prosthetic valves that are rotatable or conventional.
A rotatable prosthetic valve can include a first structural member coupled to the strut members, a second structural member rotatable relative to the first structural member, and a plurality of pliable valve members connecting the first structural member with the second structural member such that rotation of the second structural member relative to the first structural member can urge the valve members between an open and a closed state. In particular, the rotation of the second structural member can be responsive to the natural flow of a biological fluid.
A conventional prosthetic valve can include a plurality of pliable valve leaflets having commissures at the intersection of two strut members. The prosthetic valve can further include a skirt material coupled to the strut members.
A particular advantage of a support structure in accordance with embodiments of the invention is that it enables a prosthetic valve to be readily retrieved and repositioned in the body. If following deployment, the valve is malpositioned or deemed dysfunctional, the support structure allows the valve to be readily repositioned and re-deployed at a new implant site, or removed from the body entirely. This feature of the device can prevent serious complications and save lives by enabling the repair of mal-positioned devices in the body.
The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of particular embodiments of the invention, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the invention.
Particular embodiments of the invention include endoluminal support structures (stents) and prosthetic valves.
The strut members 11 are fabricated from a rigid or semi-rigid biocompatible material, such as plastics or other polymers and metal alloys, including stainless steel, tantalum, titanium, nickel-titanium (e.g. Nitinol), and cobalt-chromium (e.g. ELGILOY). The dimensions of each strut can be chosen in accordance with its desired use. In a particular embodiment, each strut member is made from stainless steel, which is 0.005-0.020 inch thick. More particularly, each strut is 0.010 inch thick 300 series stainless steel. While all struts 11 are shown as being of uniform thickness, the thickness of a strut can vary across a strut, such as a gradual increase or decrease in thickness along the length of a strut. Furthermore, individual struts can differ in thickness from other individual struts in the same support structure.
As shown, each strut member 11 is bar shaped and has a front surface 11 f and a back surface 11 b. The strut members can however be of different geometries. For example, instead of a uniform width, the struts can vary in width along its length. Furthermore, an individual strut can have a different width than another strut in the same support structure. Similarly, the strut lengths can vary from strut to strut within the same support structure. The particular dimensions can be chosen based on the implant site.
Furthermore, the struts can be non-flat structures. In particular, the struts can include a curvature, such as in a concave or convex manner in relationship to the inner diameter of the stent structure. The struts can also be twisted. The nonflatness or flatness of the struts can be a property of the material from which they are constructed. For example, the struts can exhibit shape-memory or heat-responsive changes in shape to the struts during various states. Such states can be defined by the stent in the compressed or expanded configuration.
Furthermore, the strut members 11 can have a smooth or rough surface texture. In particular, a pitted surface can provide tensile strength to the struts. In addition, roughness or pitting can provide additional friction to help secure the support structure at the implant site and encourage irregular encapsulation of the support structure 10 by tissue growth to further stabilize the support structure 10 at the implant site over time.
In certain instances, the stent could be comprised of struts that are multiple members stacked upon one another. Within the same stent, some struts could include elongated members stacked upon one another in a multi-ply configuration, and other struts could be one-ply, composed of single-thickness members. Within a single strut, there can be areas of one-ply and multi-ply layering of the members.
Each strut member 11 also includes a plurality of orifices 13 spaced along the length of the strut member 11. On the front surface 11 f, the orifices are countersunk 17 to receive the head of a fastener. In a particular embodiment, there are thirteen equally spaced orifices 13 along the length of each strut member 11, but more or less orifices can be used. The orifices 13 are shown as being of uniform diameter and uniform spacing along the strut member 11, but neither is required.
The strut members 11 are arranged as a chain of four-bar linkages. The strut members 11 are interconnected by swivelable pivot fasteners 25, such as rivets, extending through aligned orifices 13. It should be understood that other swivelable fasteners 25 can be employed such as screws, bolts, ball-in-socket structures, nails, or eyelets, and that the fasteners can be integrally formed in the struts 11 such as a peened semi-sphere interacting with an indentation or orifice, or a male-female coupling. In addition to receiving a fastener, the orifices 13 also provide an additional pathway for tissue growth-over to stabilize and encapsulate the support structure 10 over time.
In particular, the first strut member 11-1 is swivelably connected to the second strut member 11-1 by a middle swivel joint 15-1 using a rivet 25-1, which utilizes orifices 13 that bisect the strut members 11-1, 11-2. Similarly, the third strut member 11-3 is swivelably connected to bisect the fourth strut member 11-4 by a middle swivel joint 15-7 using a rivet 25-7. It should be understood that the middle swivel joints 15-1, 15-7 function as a scissor joint in a scissor linkage or mechanism. As shown, the resulting scissor arms are of equal length. It should also be understood that the middle joint 15-1, 15-7 need not bisect the joined strut members, but can instead utilize orifices 13 offset from the longitudinal centers of the strut members resulting in unequal scissor arm lengths.
In addition to the middle scissor joint 15-1, the first strut member 11-1 is swivelably connected to the third strut member 11-3 by a distal anchor swivel joint 15-5, located near the distal ends of the strut members 11-1, 11-3. Similarly, the first strut member 11-1 is swivelably connected to the fourth strut member 11-4 by a proximal anchor swivel joint 15-3, located near the proximal ends of the strut members 11-1, 11-4. To reduce stresses on the anchor rivets 25-3, 25-5, the distal and proximal ends of the struts 11 can be curved or twisted to provide a flush interface between the joined struts.
As can be seen, the support structure 10 (
Returning to
While the support structure 10 can be implanted in a patient during an open operative procedure, a closed procedure will often be more desirable. As such, the support structure 10 can include an actuation mechanism to allow a surgeon to expand or compress the support structure from a location remote from the implant site. Due to the properties of a scissor linkage wrapped into a cylinder (
In addition, because the struts overlap, a ratcheting mechanism can be incorporated to be utilized during the sliding of one strut relative to the other. For example, the stent could lock at incremental diameters due to the interaction of features that are an integral part of each strut. An example of such features would be a male component (e.g. bumps) on one strut surface which mates with the female component (e.g. holes) on the surface of the neighboring strut surface, as the two struts slide pass one another. Such structures could be fabricated to have an orientation, such that they incrementally lock the stent in the expanded configuration as the stent is expanded. Such a stent could be expanded using a conventional balloon or other actuation mechanism described in this application.
Because the support structure 10 of
The cable 42 is encased by a flexible outer sheath 48. The distal end of the outer sheath 48 includes a lip or protuberance 49 shaped to interface with the support structure 10. When the cable 42 is turned, the outer sheath lip 49 interacts with the support structure 10 to counteract the resulting torque.
By employing threads, the rod is self-locking to maintain the support structure in the desired diameter. In a particular embodiment, the rod 32, 32′ has a diameter of 1.0 mm and a thread count of 240 turns/inch. While a threaded rod and drive mechanism are described, other techniques can be employed to actuate the linkages depending on the particular surgical application. For example, the actuator mechanism can be disposed within the thickness of the strut members, instead of inside or outside of the stent. For example, worm gears or a rack and pinion mechanism can be employed as known in the art. One of ordinary skill in the art should recognize other endoluminal actuation techniques. In other situations, the support structure can be implanted during an open procedure, which may not require an external actuation mechanism.
Although there are other uses for the described support structure, such as drug delivery, a particular embodiment supports a prosthetic valve. In particular, the support structure is used in combination with a prosthetic valve, such as for an aortic valve replacement.
The leaflets 101 a, 101 b, 101 c are attached to a stationary cylindrical member 105 and a non-stationary cylindrical member 107. One side of each leaflet 101 is attached to the non-stationary cylindrical member 107. The opposing side of each leaflet 101 is attached to the stationary cylindrical member 105. The attachment of each leaflet 101 is in a direction generally perpendicular to the longitudinal axis of the cylindrical members 105, 107. In this embodiment, each leaflet 101 is pliable, generally rectangular in shape, and has a 180 degree twist between its attachments to stationary member 105 and non-stationary member 107. Each leaflet 101 has an inner edge 102 and an outer edge 103, with the edges 102 c, 103 c of one leaflet 101 c being referenced in the figure. As known in the art, the leaflets can be fabricated from either biological or non-biological materials, or a combination of both.
One way to actuate the valve to close is by utilizing the forces exerted by the normal blood flow or pressure changes of the cardiac cycle. More specifically, the heart ejects blood through the fully open valve in the direction of the arrow shown in
The function of the valve 100 opening can be understood by observing the reverse of the steps of valve closing, namely following the sequence of drawings from
In considering the valve 100 as an aortic valve replacement, it would remain closed as shown in
As the leaflets 101 elongate from a horizontal to vertical orientation along the axial plane, a net torque force is exerted on the leaflets 101 and non-stationary cylindrical member 107. Since the valve 100 is opening, as opposed to closing, the torque force exerted to open the valve is opposite to that exerted to close the valve. Given the configuration of embodiment shown in
The torque forces cause the leaflets 101 to rotate with the non-stationary member 107 around the longitudinal axis of the valve 100. This, in turn, exerts a centrifugal force on each leaflet 101. The leaflets 101 undergo radial displacement away from the center, effectively opening the valve and allowing blood to flow away from the heart, in the direction shown by the arrow in
To summarize, the valve passively functions to provide unidirectional blood flow by linking three forces. Axial, torque, and radial forces are translated in a sequential and reversible manner, while encoding the directionality of prior motions. First, the axial force of blood flow and pressure causes the displacement of the leaflets 101 and non-stationary members 107 relative to the stationary member 105 along the axial plane. This is translated into a rotational force on the leaflets 101 and non-stationary member 107. The torque force, in turn, displaces the leaflets 101 towards or away from the center of the valve, along the radial plane, which closes or opens the valve 100. The valve 100 passively follows the pathway of opening or closing, depending on the direction of the axial force initially applied to the valve by the cardiac cycle.
In the body, the stationary cylindrical member 105 can secured and fixed in position at the implant site, while the non-stationary member 107 and distal ends of leaflets 101 are free to displace along the axial plane. In using the prosthetic valve as an aortic valve replacement, the stationary member 105 would be secured in the aortic root. As the blood pressure or flow from the heart, increases, the valve 100 changes from its closed configuration to the open configuration, with blood ejecting through the valve 100.
Specific advantages of the rotating valve of
The stented valve 110 can be implanted during a closed procedure as described above. However, because of the operation of the non-stationary member within the body of the stent, the actuator mechanism to compress and expand the stent would not be disposed within the stent.
Further embodiments of the stented valve 110, positioning of the valve in the body, and procedures for implantation are described in the above-incorporated parent provisional patent application. In addition, a tissue valve can be draped on the support structure. Additional embodiments should be apparent to those of ordinary skill in the art.
The tissue valve 121 includes three pliable semi-circular leaflets 121 a, 121 b, 121 c, which can be derived from biocompatible materials as noted with reference to
From the commissures, the leaflet sides are connected to the adjacent diagonal struts. That is, the sides of the first leaflet 121 a are sutured to the struts 11-Xa and 11-Za, respectively; the sides of the second leaflet 121 b are sutured to the struts 11-Xb and 11-Yb, respectively; and the sides of the third leaflet 121 c are sutured to the struts 11-Yc and 11-Zc, respectively. Those sutures end at the scissor pivot points on the diagonal struts.
In the configuration shown, neighboring struts 11 are attached to one another in a manner that creates multiple arches 128 at the ends of the stent. Posts for leaflet attachment, or commissures, are formed by attaching neighboring leaflet to each of the struts that define a suitable arch 128 x, 128 y, 128 z. In the configuration shown, there are three leaflets 121 a, 121 b, 121 c, each of which is attached to a strut along two of its opposing borders. The commissures are formed by three equi-distance arches 128 x, 128 y, 128 z in the stent.
The angled orientation of a strut in relationship to its neighboring strut enables the leaflets 121 a, 121 b, 121 c to be attached to the stent in an triangular configuration. This triangular configuration simulates the angled attachment of the native aortic leaflet. In the native valve this creates an anatomical structure between leaflets, known as the inter-leaflet trigone. Because the anatomical inter-leaflet trigone is believed to offer structural integrity and durability to the native aortic leaflets in humans, it is advantageous to simulate this structure in a prosthetic valve.
One method of attachment of the leaflets to the struts is to sandwich the leaflet between a multi-ply strut. The multiple layers are then held together by sutures. Sandwiching the leaflets between the struts helps to dissipate the forces on leaflets and prevent the tearing of sutures through the leaflets.
The remaining side of each leaflet 121 a, 121 b, 121 c is sutured annularly across the intermediate strut members as shown by a leaflet seam. The remaining open spaces between the struts are draped by a biocompatible skirt 125 to help seal the valve against the implant site and thus limit paravalvular leakage. As shown, the skirt 125 is shaped to cover those portions of the stent below and between the valve leaflets.
In more detail, the skirt 125 at the base of the valve is a thin layer of material that lines the stent wall. The skirt material can be pericardial tissue, polyester, PTFE, or other material or combinations of materials suitable for accepting tissue in growth, including chemically treated materials to promote tissue growth or inhibit infection. The skirt layer functions to reduce or eliminate leakage around the valve, or "paravalvular leak". To that end, there are a number of ways to attach the skirt material layer to the stent, including:
The above list is not necessarily limiting as those of ordinary skill in the art may recognize alternative draping techniques for specific applications.
The tissue valve structures 120, 120′, 120″ can also be implanted during a closed procedure as described above. However, the actuator mechanism to compress and expand the stent would be attached to avoid the commissure points and limit damage to the skirt layer 125, 125′, 125″, such as by mounting the actuator mechanism on the outer surface of the stent 10.
While the above-described embodiments have featured a support structure having linear strut bars and equal length scissor arms, other geometries can be employed. The resulting shape will be other than cylindrical and can have better performance in certain applications.
The stent 10′ can also assume a cone shape in its expanded configuration by imposing a convex or concave curvature to the individual strut members 11 that comprise the stent 10′. This could be achieved by using a material with memory, such as shape-memory or temperature sensitive Nitinol.
A valve can be orientated in the cone-shaped stent 10′ such that the base of the valve was either in the narrower portion of the cone-shaped stent, with the nonbase portion of the valve in the wider portion of the cone. Alternatively, the base of the valve can be located in the widest portion of the stent with the non-base portion of the valve in the less-wide portion of the stent.
The orientation of a cone-shaped stent 10′ in the body can be either towards or away from the stream of blood flow. In other body lumens (e.g. respiratory tract or gastrointestinal tract), the stent could be orientated in either direction, in relationship to the axial plane.
An hourglass stent configuration could also be achieved by imposing concave or convex curvatures in individual bars 11″. The curvature could be a property of the materials (e.g. shape-memory or heat-sensitive Nitinol). The curvature could be absent in the compressed stent state and appear when the stent is in its expanded state.
It should be noted that any of the above-described support structures can be extended beyond the anchor joints at either of both ends of the stent. By coupling a series of stents in an end-to-end chain fashion, additional stent lengths and geometries can be fabricated. In particular, an hourglass-shaped stent could be achieved by joining two cone-shaped stents at their narrow ends. The hourglass shape can also be modified by assembling the middle scissor pivots off center as shown in
Particular embodiments of the invention offer distinct advantages over the prior art, including in their structure and applications. While certain advantages are summarized below, the summary is not necessarily a complete list as there may be additional advantages.
The device allows the user to advert the serious complications that can occur during percutaneous heart valve implantation. Because the device is retrievable and re-positionable during implantation into the body, the surgeon can avoid serious complications due to valve mal-positioning or migration during implantation. Examples of these complications include occlusion of the coronary arteries, massive paravalvular leakage, or arrthymias.
The device can also decrease vascular access complications because of the device's narrow insertion profile. The device's profile is low, in part, due to its unique geometry, which allows neighboring struts in the stent to overlap during stent compression. The device's low profile is further augmented by eliminating the necessity for a balloon or a sheath. The device's narrow profile offers the advantage of widening the vascular access route options in patients. For instance, the device can enable the delivery of the prosthetic valve through an artery in the leg in a patient whom would have previously been committed to a more invasive approach through the chest wall. The device therefore aims to decrease complications associated with the use of large profile devices in patients with poor vascular access.
The tissue valve embodiments can offer improved durability by allowing for attachment of the leaflets to flexible commissural posts. The flexible posts allow dissipation of the stress and strain imposed on the leaflet by the cardiac cycle. The use of multi-ply struts enables the leaflets to be sandwiched in between the struts, which re-enforces the leaflet attachments and prevents tearing of sutures. The valve further assumes a desirable leaflet morphology, which further reduces the stress and strain on leaflets. Namely, the angled leaflet attachment to the stent is similar to the native human aortic valve's inter-leaflet trigone pattern. These properties significantly improve the longevity of percutaneous heart valve replacement therapies.
The device could reduce or eliminate arrthymia complications due to the incremental expansion or compression of the stent. The stent can employ a screw mechanism for deployment, which enables the stent to self-lock or un-lock at all radii. This enables more controlled deployment and the potential for individualizing the expansion or compression of the device in each patient. Because the expansion or compression of the device is reversible at any stage during the procedure, the surgeon can easily reverse the expansion of the device to relieve an arrythmia. In addition, if an arrythmia is detected during implantation, the device can be repositioned to further eliminate the problem.
The device can reduce or eliminate paravalvular leak due to the device's ability to be accurately positioned, and re-positioned, if necessary. That can considerably decrease the occurrence and severity of paravalular leaks.
The device eliminates balloon-related complications. The screw mechanism of deployment exploits the mechanical advantage of a screw. This provides for forceful dilation of the stent. The lever arms created by the pivoting of the struts in the scissor linkage of the stent, transmits a further expansion force to the stent. The stent is expanded without the need for a balloon. In addition, the ability of the device to be forcefully dilated reduces or eliminates the need for pre- or postballooning during the implantation procedure in patients.
The device has more predictable and precise positioning in the body because the difference between the height of the stent in the compressed and expanded position is small. This "reduced foreshortening" helps the surgeon to position the device in the desirable location in the body. The ability to re-position the device in the body further confers the ability to precisely position the device in each individual.
In addition to the mechanical advantages, the device enables a wider population of patients to be treated by a less invasive means for valve replacement. For example, the device enables patients with co-morbidities, whom are not candidates for open chest surgical valve replacement, to be offered a treatment option. The device's ability to assume a narrow profile also enables patients who were previously denied treatment due to poor vascular access (e.g. tortuous, calcified, or small arteries), to be offered a treatment option. The durability of the valve should expand the use of less-invasive procedures to the population of otherwise healthy patients, whom would otherwise be candidates for open chest surgical valve replacement. The device's ability to be forcefully expanded, or assume hourglass, or conical shapes, potentially expands the device application to the treatment of patients diagnosed with aortic insufficiency, as well as aortic stenosis.
The device can also provide a less invasive treatment to patients with degenerative prosthesis from a prior implant, by providing for a "valve-in-valve" procedure. The device could be accurately positioned inside the failing valve, without removing the patient's degenerative prosthesis. It would help the patient by providing a functional valve replacement, without a "re-do" operation and its associated risks.
While this invention has been particularly shown and described with references to particular embodiments, it will be understood by those skilled in the art that various changes in form and details may be made to the embodiments without departing from the scope of the invention encompassed by the appended claims.
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Crysis 2 vs. Rage: Gametrailers' Best Graphics of E3 Award Goes to...
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Loving Everything Me
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Location: Tampa, FL
Posts: 8,033
Re: Crysis 2 vs. Rage: Gametrailers' Best Graphics of E3 Award Goes to...
Originally Posted by
I'm glad kirby took it. They're doing something different with the graphics and it's something that besides kinda like little big planet, it's not been seen. Tech5 and Cryengine 2 are impressive but it's nothing we haven't already seen and I think for once they're judging the graphics quality not on how many polygons it can crank out but more on style and visual appeal.
For me personally, I would enjoy looking at crysis or rage any day over kirby but games with that more artistic approach are really nice to see in their own way and I don't feel like I'm missing anything when I go from playing stalker or dead space or mass effect to 3D dot game heroes or little big planet.
There is a lot of artistry in more realistic games too, people seem to forget that. I do agree that trying new things is good though and games like Borderlands and Mirror's Edge look amazing with their stylized graphics and tech specs combined.
I gots one of them high powered gaming computers with an EVGA GTX 480 video thingy and a Q9550 processing device and also one of them Windows 7 64 operating programs with 4GB of some Corsair 1033 DDR2 ram.
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The Giant Beastcast: Episode 06
Become Premium to Watch
Her Story is a bold and largely successful experiment in interactive crime fiction.
Rocksteady's gorgeous-looking third Arkham game refines its open-world format a bit and lets you drive a whole hell of a lot of Batmobile.
It's squid kids and ink blasting abound in Nintendo's exceptionally fun new online shooter.
Game »
consists of 6 releases.
Released Aug 24, 2000
A kind of protective clothing.
An artifact (or artefact) is an object discovered through archaeology, usually man made or modified. Often highly valuable and sought after by collectors.
The axe is a tool used for many activities. Its uses include cutting wood, knocking down doors in emergencies, and rending your enemies limb from limb without mercy or regret.
A watercraft designed to travel on top of bodies of water. A favored tool of pirates and criminals.
A bomb is an explosive device.
The bread and butter of any self respecting archer, the bow is a stereotypical ranged weapon of olden times and fantasy settings.
From weapon, to trap, to calculated (albeit rough) transport, the catapult has many applications. Usually found on the medieval battlefield, this item exists in modern variations that hardly resemble its original form.
Crates sometimes contain things!
Doors are a common object in most video games, as well as the keys and objects needed to open them. From role playing to shooters, doors are an important component of many games.
A valuable item that is highly sought after, often used as a reward or incentive to complete objectives. Also used as a currency in many role-playing games.
Considered one of the most frequent and controversial implements of destruction in video games and real life, guns are devices that fire projectiles with explosive force.
A two-handed polearm consisting of an axe on a long shaft, good for defending against cavalry and infantry alike.
A mobile cannon and one of the earliest types of firearm.
Whether it's worn for protection or style, helmets appear in various game genres.
Armor. But for horses.
A lance is a long range combat weapon that appears in many games.
Used to turn wind or water energy into useable mechanical work.
This be a ship owned by pirate scum, usually with skull 'n' crossbones flags and cannons. Arrrrrgh!
Any firearm meant to be held with two hands, a rifle is a video game object that appears in many combat related video games.
The premier choice in your defensive needs. A great companion for any one handed sword, which in addition to blocking can be used for advanced maneuvers like Shield Bashes.
Vessel for transportation through water.
Stone and rock share many of the same mineralogical properties. Stone is often used to construct freestanding durable structures, requiring a great deal of force to break.
A length of exceptionally sharp metal with a handle, used for centuries as the go-to killing device for the human race. It's dead simple: you stick the pointy end in the thing you want to die. Or you could always slash them with the equally sharp sides. That works too.
A throwing axe is an axe that is used primarily as a missile weapon. Usually, they are thrown in an overhand motion (much like throwing a baseball) in a manner that causes the axe to rotate as it travels through the air.
Trees are resources.
A bird that can be prepared in many delicious manners. Often served on special occasions with stuffing and a wide variety of sides.
Turkey legs can normally be found after punching a trash can in your local crime infested alley and can boost your health back by 50%.
Wood, a resource most commonly harvested from trees and brush, grows a single ring for each year of the host plant's life. Wood often varies in color, variety, structure, and water content. it plays a vital role in crafting, building, and the culinary arts. And wood is often used as a resource for fuel and heat in lieu of fossil fuels like coal.
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Does your doctor nag you about your drinking? The federal government wishes he would.
Last week the U.S. Centers for Disease Control and Prevention (CDC) noted with alarm that most Americans saythey have never discussed alcohol consumption with a health professional. Physicians' reluctance to broach the subject is especially troubling, the CDC said, because "at least 38 million adults in the U.S. drink too much."
Most news outlets reported the latter claim as a fact, failing to notice the value judgments embedded in it. Contrary to what the CDC wants you to believe, the question of what it means to drink too much is a matter of moral and medical dispute.


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Beef With Olives And Almonds
29 Jul 2010
|Hot cooked rice
Cook and stir beef, onion and garlic in 10-inch skillet until beef is light brown; drain.
Add tomatoes, green pepper, raisins, salt, cinnamon and cloves.
Cover and simmer 10 minutes.
Cook and stir almonds over medium heat until golden, 2 to 3 minutes.
Stir almonds and olives into beef mixture.
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Beef With Olives And Almonds Recipe


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GDC 2008: Gears of War 2 Announced! Release Date Included!
Written Wednesday, February 20, 2008 By Jason Debelyak
That's right ladies and gentlemen, Cliffy B just dropped the bombshell minutes ago! Gears of War 2 is indeed coming to the Xbox 360, and much earlier than most of us were dreaming about. The all-red trailer of Locusts and Marcus Fenix came on the screen in San Francisco in front of the highly-anticipated crowd.
Cliffy B came on stage afterwards, after chainsawing through a sheet of paper and had these words to say, "Gears of War one was a setup. Gears of War 2 will be much bigger and available exclusively on Xbox 360 in November 2008".
There you have it! We will be expecting Gears of War 2 by the end of the year, and I know I'm not the only one that has been waiting for this announcement! Stay tuned for more information as we hear it. But, for now, view the debut trailer below:


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The Power of Independent Thinking
Alexander Tabarrok on Folly of Gun Buyback Programs
Recorded: Friday, February 8, 2013
Research Director Alex Tabarrok speaks about gun buyback programs on Seattles KIRO-TV.
Type: TelevisionIssues: Crime, Culture/ Society, Law Enforcement
Art Carden Talks Price Gouging on Stossel
Recorded: Thursday, November 1, 2012
Research Fellow Art Carden on Stossel discusses the positive aspects of price gouging during natural disasters.
Experts: Art CardenType: TelevisionIssues: Business, Economic Policy, Economists, Free Market Economics, Law Enforcement
Student Perspectives
2012 Summer Seminar for High School Students
Recorded: Friday, June 22, 2012
Each year the Independent Institute holds two week-long session of its Summer Seminar for Students for high school and college age students. These clips are highlights from our 2012 session for high school students.
Experts: Benjamin W. PowellType: Challenge of Liberty SeminarsIssues: Culture/ Society, Economic History and Development (International), Economic History and Development (U.S.), Economic Policy, Economists, Free Market Economics, Political Ideology and Philosophy
UFM Presentation of Living Economics: Yesterday, Today, and Tomorrow
Recorded: Sunday, June 3, 2012
Part 1 |
Part 2
Part 3
Part 4
Research Fellow Peter J. Boettke gives a talk based on the triple meaning of the title of his new book, Living Economics: Yesterday, Today, and Tomorrow, at the Univeridad Francisco Marroquin.
Experts: Peter J. BoettkeType: TelevisionIssues: Economic History and Development (U.S.), Economists, Education
Robert Higgs on the Market for Quality Assurance
Recorded: Wednesday, November 2, 2011
This presentation by Independent Institute Senior Fellow Robert Higgs was presented on July 29, 2011, at Mises University, sponsored by the Ludwig von Mises Institute, in Auburn, Alabama.
Experts: Robert HiggsType: Other EventIssues: Bureaucracy and Government, Corporate Welfare, Economists, Free Market Economics, Freedom, Politics, Public Health/ Consumer Protection
Alexander Tabarrok on Bounty Hunting & Defending the Indefensible
Recorded: Thursday, August 18, 2011
Alexander Tabarrok, Research Director at the Independent Institute, speaks with John Stossel of Fox Business Networks Stossel on bounty hunting and defending the indefensible.
Experts: Alexander T. TabarrokType: TelevisionIssues: Crime, Criminal Justice/ Prisons, Law Enforcement, Privatization
Anthony Gregory on Marginal Revolution and the Austrians
2011 Summer Seminars for College Students
Recorded: Wednesday, August 3, 2011
This presentation is from our 2011 Challenge of Liberty Summer Seminar for college students, which was held from August 1 to 5, 2011, at Notre Dame de Namur University, Belmont, California.
View videos and more information about the Summer Seminars.
Experts: Anthony GregoryType: Challenge of Liberty SeminarsIssues: Economists
José Yulo on Ethics and Liberty
2011 Summer Seminars for College Students
Recorded: Monday, August 1, 2011
Experts: José Maria J. YuloType: Challenge of Liberty SeminarsIssues: Economic History and Development (U.S.), Economists, Government Power, History (U.S), Political Ideology and Philosophy


text:
Originally written on Soccerlens | Last updated 4/25/13
David Moyes talks about how Everton have done so well and their future without Neville - originally posted on Soccerlens.comEverton are preparing to face Fulham at Goodison Park on Saturday. The Toffees are sixth on the Premier League table and they have outdone their Merseyside rivals, Liverpool, by five points. With only four games left to go in the league, David Moyes spoke to Yahoo as part of their deal with the League Managers Association. In the interview, Moyes assessed Everton's 2012/13 campaign and the key factors involved in achieving the cohesion evident in the team. Moreover, he talks about his players: Marouane Fellaini, Phil Neville and the 19-year-old England U-21 midfielder Ross Barkley. David Moyes discusses Fellaini's effectiveness in the midfield, how the dressing room will handle Neville's absence and what Neville might do after his retirement. Talking about the youngster Barkley, Moyes mentioned that patience is the key with him and he needs time to develop. He...
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From a child's very first first class to the advanced, West Chester Academy has a class for everyone in music, dance, acting, and gymnastics. We specialize in beginners of all ages and offer training through pre-professional levels. West Chester Academy is home to over 40 highly qualified, professional, and nurturing instructors. They work diligently to create a fun learning community where students of all abilities are inspired to reach their highest potential. Families often find that our broad range of offerings allows them to place multiple family members in different lessons at the same time, saving valuable time and energy.
Call our friendly hospitality team at 829-2345 for assistance in finding the right classes. West Chester Academy is located at 8107 Market Place Drive, minutes from Liberty Township, Mason, Fairfield, and Cincinnati in West Chester, Ohio.
Thank you for considering West Chester Academy, and welcome to our family!


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Civil Liberties and Human Rights Q&A 2004-2005
Edited by Helen Fenwick, Howard Davis
Routledge-Cavendish – 2004
Routledge-Cavendish – 2004
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Elvis's presence was in the building at the Loews hotel in Santa Monica for the annual eight day American Film Market (AFM) hoping to convince the 1,670 buyers from over 70 countries to buy the rights to the upcoming film "Elvis and Nixon" starring Michael Shannon as Elvis and Kevin Spacey as Nixon.
While neither artists nor critics exactly choose their predisposition or disposition, and certainly don't choose the historical epoch in which they live, it becomes increasingly difficult to imagine an intellectual or cultural sphere in which the postmodern exceeds the metamodern in either mimetic rigor or emotional and moral amplitude.
When we speak of modernism and postmodernism, and for that matter when we speak of metamodernism, what we mean by "movement" is a series of ideas in philosophy that are a) the subject of scholarly study and discussion, and b) can serve as actionable intelligence for various artists' creative practices.


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Moab 20
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As a modern family-run company and a sustainable innovative outdoor outfitter, VAUDE takes its responsibility for people and nature very seriously. We bring this claim to life in all three of our divisions: Mountain Sports, Bike Sports and Packs 'n Bags.
For 40 years, VAUDE has stood for high quality outdoor clothing and equipment for mountain sports and the perfect equipment for cycling fans. We make outdoor clothing, shoes, backpacks, tents, sleeping bags and accessories for mountaineering, ski mountaineering, trekking, hiking, mountain biking and road cycling.


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All quotes tagged Inspirationals
(16424 quotes found)
"As a child, we are called liars for having a wild imagination. As an adult, we are called authors."
"Daydreamers literally wonder into their own little world, yet only few have the guts to share it with the world."
"¿Acaso un hombre ciego desea ver un hermoso cielo de azul? O más bien, prefiere imaginar un cielo de color diferente para cada día de la semana?"
"You had my pat and destroyed it but my present and my future you shall not have No part of. For you were just a fly that always bothered me, a moron who will never be smarter then me, and a TV that I have decided to keep on mute because your voice irritates the hell out of me!!!!"
"Every tick, every tock beeps once never beeps again. every second an every minute teaches you and give you a lesson how to deal with the next."
"See the whole new world by your stable positive eyes which can see things in positive ways and can differentiate the things and see them in their own way. yes, u will feel the change."
"Love is indestructible. love can make your life heaven also a hell. it can make u an angel also demon. love never comes with validity of realtionships u create, Everythin happen like whole world conspires to make it happen. dont ever fool yourself in love. If u dont give ur 100% you shall not recieve the same."


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|Home ---> Data Recovery Software ---> Android Recovery Software
Android Recovery Software
Many tablet PC, smart phones and other devices are developed with this OS. Most of the people who are using these android devices might ever meet such situations where they needed to perform android data recovery to recover lost data from android devices. Android data recovery software swiftly recovers all lost files and folders from android technology based devices like android mobile phones, android tablet pc and other android devices.
If you have lost data from android device and intended to recover them back then go through the following steps that can help you to recover your android data.
Tips for successfully android data recovery
After the data loss occurrence don't store any new data in it because the old data may be overwritten by the new data.
Software highlights
Android data recovery software provides ideal solution to recover mistakenly deleted files and folders from various android devices like android tablet PC, Android smart phones and other android technology based devices. Android data restoration program is developed with different searching modes (Basic Search, Deep Search, Photo Search, Video Search and Signature Search) to search and recover all lost android data.


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32 year old man | Washington, DC, USA | Seeking women 24-34 within 50 miles
Who's out there????
I've been in the Marine Corps for 10 years now and stationed in DC. My last 2 duty stations were a blast and I was able to travel all over the world. Places like Australia, Tonga, Samoa, New Zealand, Japan, Thailand and Hawaii. I'm a Photography, Video, Audio Engineer for the Marine Corps. As a side hobby I enjoy artistic/glamour photography and have even been published in a few magazines. I was born and raised in Panama City, FL where I attended some Music college before joining the Marines. My first 6 years in the Marines I spent as a Guitarist in the Marine Corps Band in SC and Hawaii so if you like Music or enjoy playing or being serenaded look out ;) Hobbies/Interests/things I love: 1) cross fit (everyday if possible), 2) anything active, 3) movies either in the theater or at home on Netflix, 4) teaching others my passion; I assist others in learning the skill of photography/editing. I'm looking for a lady that is confident in themselves and has direction in life. I would love to find someone that spends one night curled up and watching a movie with me and the next takes time to spend it with her girlfriends; someone who has interests and passions and also makes time to build a relationship and someone who likes to live and have fun.
Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Playing cards , Playing sports , Travel/Sightseeing , Watching sports , Wine tasting
Basketball, Billiards / Pool, Bowling, Football, Golf, Running, Swimming, Tennis / Racquet sports, VolleyBall, Walking / Hiking, Weights / Machines
I exercise 3-4 times per week.
I like Dogs
I have a 3 pound chihuahua named Pierre:)
Middle of the Road
I love Hawaii and Australia. In the DC area there are so many great spots: Masa 14 for sunday brunch or Lola's for a happy hour.
Berklee College of Music, Boston, MA
Love classic rock. new foods. wine tasting is fun, Music, Bar hopping is fun
Love Movies. Computers are fun. Hiking, Beach, I'm easy to please lol Im really into photography. i been shooting for about 4-5 years and its a very serious hobby for me.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|6'1" (185cms)
|5'5" (165cms) to 5'10" (177cms)
|Body type:
|Athletic and toned
|Slender, Athletic and toned
|Blue, Brown, Green, Hazel
|Light brown
|Auburn / Red, Light brown, Dark brown, Blonde, Dark blonde, Platinum
|No Way
|Social Drinker
|Social Drinker, Regularly
|Political / Govt / Civil Service / Military
|Administrative / Secretarial, Artistic / Creative / Performance, Executive / Management, Financial / Accounting / Real Estate, Labor / Construction, Legal, Medical / Dental / Veterinary / Fitness, Political / Govt / Civil Service / Military, Retail / Food services, Sales / Marketing, Self-Employed / Entrepreneur, Student, Technical / Science / Computers / Engineering, Travel / Hospitality / Transportation, Other profession, Nonprofit / Volunteer / Activist, Law enforcement / Security / Military, Fashion / Model / Beauty, Architecture / Interior design
Staff Sergeant in the US Marine Corps
|I'll tell you later
|$50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married, Widow / Widower, Currently Separated, Divorced
|Have kids:
|Wants kids:
|Definitely, Someday
|White / Caucasian
|Latino / Hispanic, White / Caucasian
|I'll tell you later
|Christian / Catholic, Christian / LDS, Christian / Protestant, Other, Christian / Other
|Some college
|High school, Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral
i'm a few semesters from a Music degree. 1 semester at a time :) im also almost done with my Music Production using Pro Tools Master Certificate from Berklee Music. I also have a few Certifications in Audio Engineering.


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The Titans met with agent Drew Rosenhaus Tuesday to continue discussions about a contract extension for DT Jurrell Casey.
Titans GM Ruston Webster "expects to get an extension worked out" with walk-year DT Jurrell Casey.
Jurrell Casey remains in contract extension negotiations with the Titans.
Titans DL Jurrell Casey has dropped 15 pounds since last offseason, and will play around 290 this season.
The Titans and DL Jurrell Casey have engaged in discussions about a contract extension.
Titans DT Jurrell Casey claims he will remain a one-gap penetrator in new DC Ray Horton's 3-4 defense.
Titans DL Jurrell Casey has dropped 15 pounds this offseason and now weighs 290.
Titans DT Jurrell Casey missed the season finale with a knee injury and wasn't medically-cleared to participate in the Pro Bowl.
The Titans do not believe DT Jurrell Casey's Thursday night shoulder injury will cost him any time.
Titans DT Jurrell Casey left Thursday night's game against the Steelers with a right shoulder injury and will not return.
Titans selected USC DT Jurrell Casey with the No. 77 overall pick in the 2011 NFL draft.
Former 49ers and Cardinals scout Dave Razzano believes USC DT Jurrell Casey is being "completely overlooked" early in the draft.
USC DT Jurrell Casey has reportedly looked "unimpressive" during pre-Combine preparation.
USC DT Jurrell Casey will forgo his senior season with the Trojans and enter the 2011 NFL draft.


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Biological Psychology (Hardcover)
|Author: Stephen B./ Thorne Klein
$10 off $75 Home, Sports, School Supplies, Fashion, & Beauty - Back to School. Use promo code BACK2SCHOOL at checkout. Ends 7/8/2015.
Learn more about Biological Psychology:
Format: Hardcover
Publisher: Macmillan Higher Education
Sku: 204113674
Publish Date: 12/31/2007
Dimensions: (in Inches) 11H x 8.75L x 1.25T
Pages: 720
Age Range: NA
See more in Physiological Psychology
|Klein and Thorne''s "Biological Psychology" offers a comprehensive and up-to-date presentation of the processes by which biological systems--most notably the nervous system--affect behavior. It connects with students through a combination of accessible, example-rich writing, student-friendly pedagogy, a carefully developed original art program, and media and supplements created specifically for this book. The result is the ideal text for instructors looking to guide their students through this captivating subject.


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Yep, Liam's done it again and made us all weak in the knees. The 1D member saved his friend's life from a ferocious fiyahh! Talk about smolder. HA, GE...
Let's get Hillary Rodham Clinton on one of these lists. What's sexier than a woman in a pants suit brokering world peace, slurping soup and discussing sanctions with the Prime Minter of Yalangistan? Trick question. There is nothing sexier.
Here, we present ten celebrities epitomizing the beauty of humanitarianism in ways about which we're betting even the hosts of E!'s Fashion Police can't find anything to criticize.
In the weeks before Election Day, voters are again being targeted with intimidation tactics and deceptive practices to confuse or scare them out of casting a ballot. In Ohio and Wisconsin, for example, billboards popped up in primarily African-American neighborhoods with messages such as "Voter Fraud is a Felony! Up to 3½ YRS and a $10,000 Fine," designed to alarm and confuse residents.
A staunch environmental advocate, the 31-year-old star recently launched the Honest Company, which makes nontoxic, ecofriendly baby gear. She took some time to answer our questions about her commitment to safe chemistry.
In a summer of movies made of bombastic special effects and obvious action, Killer Joe still has the ability to surprise by keeping it down and dirty -- though you'll need a strong stomach to make it to the end.
Like all parents, I want my girls to grow up in a world where they can pursue their dreams, build the career they imagine and ultimately have more opportunities to succeed than generations past. But I see the challenges young Americans currently face and I know I want them to have a better, brighter future.
The event has grown beyond poets to become a coordinated effort by teachers, publishers, non-profit and government agencies, corporate sponsors, and lots and lots of celebrities.
As e-commerce grows as a category most e-commerce companies are focused on women because they are the decision makers and the consumers
You don't need to have a lot of money -- or be a celebrity -- to get in shape!
This past week I came across a large number of weight quotes attributed to various starlets that I feel need debunking -- both for their sake and for ours.
As an L.A.-based celebrity trainer, with A-list clients such as Jessica Alba and Halle Berry, choosing "don't do it for a 'Hollywood body'" as a topic for my first blog may sound like a contradiction.
A year-round staple, the perfect little leather jacket is as chic on a chilly Hamptons evening as a crisp New York afternoon. On the quest to find the right fit, Lyndsey Butler decided to try designing one of her own.
Rimowa's and Hugo Boss' unrelenting craftsmanship hasn't resonated in a major way with the American consumer. Far from retreating, these brands are going on the luxe offensive.
The law of diminishing returns is a law for a reason. And nowhere are the returns more diminished than Little Fockers, the third film in a series that began in 2000. With this one, they've barely bothered with a plot.


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Ad industry seeks image makeover of its own
COLUMBIA, Mo. From gimlet-swilling adulterers on TV's "Mad Men" to seven-figure fines for deceptive ads touting cold remedies and credit scores, the ad industry sure could use an image makeover of its own.
Industry leaders are teaming up with the nation's oldest journalism school to launch the Institute for Advertising Ethics. Among the research center's goals is to improve the public image of a business that spent $125 billion last year but isn't exactly known for its bedrock principles and unwavering scruples.
Whether it's the duplicitous exploits of fictional television character Don Draper or the latest penalties levied by the Federal Trade Commission, the ad industry struggles to put its best face forward. A 2007 Gallup survey ranked advertisers among the least trustworthy professionals - barely beating out lobbyists and car salesmen.
"Because it is persuasion, advertising is viewed in a questionable way by a lot of people," said Margaret Duffy, a former ad executive who now teaches at the University of Missouri School of Journalism and is helping to organize the ethics institute.
But even though the industry's fundamental purpose is to convince shoppers to buy a product they may not actually need, such persuasion can be done in an "ethical and tasteful" way, she added.
The research center's leader is visiting professor Wally Snyder, a former FTC lawyer and American Advertising Federation president. While acknowledging the need to improve the industry's reputation, he emphasized that the institute will also benefit the people who view ads.
Snyder pointed to research that suggests consumers are more likely to do business with companies they consider ethical, ones that don't use deceptive ads.
"This is what consumers want, and expect," he said.
The ethics institute is just part of a broader PR campaign envisioned by the industry.
The Washington-based trade group once led by Snyder is shopping a reality TV show featuring young ad reps - a "Mad Men" for the modern age. The federation also wants to shift its industry Hall of Fame, an online entity, to a physical location in New York City.
According to the oft-cited 2007 survey, the industry can use the help. Just 6 percent of respondents ranked advertisers' ethics as "high" or "very high," with 42 percent ranking their ethics as "low" or "very low."
Nursing, the top-ranked of the 22 professions listed, received an 83 percent trustworthy ranking. Even nursing home operators (21 percent), lawyers (15 percent) and members of Congress (9 percent) scored higher.
The research center will be affiliated with Missouri's Reynolds Journalism Institute, a nonprofit think tank and futures lab intended to help the struggling industry figure out new ways to make money while embracing technology and re-engaging a skeptical and time-pressed citizenry.
Its priorities include developing a voluntary code of ethics, honoring businesses for ethical behavior and examining the effects of social media and digital technology on the ad world.
The first principle of the ethics code, as envisioned by Snyder, outlines advertising's purpose as "to provide commercial information that will assist consumers in their purchase decisions in a truthful, fair and cost-effective manner."


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Gear Review
pop it like its hottt!
This board has more pop than air jordans. I can't believe how well rome nailed this board. If your looking for a deck that can butter like a rockst*r this is the one 4 you. 5 ***** for the artifact 1985!
View More Details on Rome Artifact 1985 Snowboard


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February 13, 2010
Framed through the curving edges of a wine glass, Jean Carwile Masteller appears to experience an in and out of body experience during Forgeron Cellars' sensory class Saturday afternoon at the winery. Her husband Richard Masteller sits across the table from her as the two listen to winemaker Marie-Eve Gilla talk about the nuances of sensing different aromas and tastes.
Stories this photo appears in:
Winery's sensory class teaches how to taste
WALLA WALLA — The basics of taste — sour, sweet and bitter, minus the salt, but add viscosity — were taught at Forgeron Cellars on Saturday afternoon, at what Marie-Eve Gilla likes to call an entry-level class on the senses and wine.'The whole idea is to
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And too few insights gleaned from them
Blocking HIV
February 19, 2015|
A synthetic antibody prevents infection in four monkeys injected with heavy doses of the virus.
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A synthetic antibody prevents infection in four monkeys injected with heavy doses of the virus.
February 17, 2015|
Genetic tests have not revealed the source of the viral outbreak that started in California's Disney theme parks, according to the Centers for Disease Control and Prevention.
February 11, 2015|
To more accurately reflect the condition, the Institute of Medicine recommends renaming it systemic exertion intolerance disease.
February 5, 2015|
Researchers design a device that attaches to a smartphone to test for diverse infectious diseases from a drop of blood.
February 4, 2015|
Genetically modified T memory stem cells persist in patients for more than 10 years, and can differentiate into a variety of T cell types.
February 2, 2015|
As the number of Ebola cases declines, Chimerix is unable to recruit enough patients for its trial in Liberia testing the antiviral drug brincidofovir.
February 2, 2015|
In the introduction to his latest book, author Melvin Konner explains why he considers maleness a departure from normal physiology.
February 1, 2015|
Touch, The Altruistic Brain, Is Shame Necessary?, and Future Arctic
February 1, 2015|
A strain of the dysentery-causing bacterium isolated in 1915 tells the story of a young soldier who died of the disease in the early days of World War I.
February 1, 2015|
A chemical engineer walks into a biology lab . . . and revolutionizes bioengineering. How Robert Langer blazed a trail in drug delivery and regenerative medicine.


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The F800GS Seat
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Gnarly Adventurer
Joined: Mar 2012
Location: Seattle, WA
Oddometer: 169
i got this bike used a couple months ago. the guy sold gave me a Sargent comfort seat in standard height. he sold the OEM standard height.
i's been ok. it is too dished out for me and impeded my ability to scoot around and only really has one seating position pretty much. but the bigger problem was angle of the seat. it pitched you forward, and i felt like i was sitting on a slant when all the way back planted in the seat. i found it uncomfortable on long stretches and i get super painful should ache. that being said, i know lots of people find the seat super comfortable so it's a personal thing.
i bought this TT low seat which on initial impression limited to short rides, the seat is much flatter. you can't tell really because the picture is deceiving. the cover is wrapped tightly and doesn't stick to the foam at the rear portion of the saddle. the foam is actually cut much flatter than you can see.
so far it's a winner. i will test on longer range hopefully soon....
for reference, i am 5'8" 30 " inseam (that's being generous sadly...) and i can stand on the balls of both feet with regular shoes on. haven't ridden with MX boots on yet but i suspect it should be fine.
also i tried the standard height TT comfort seat and it was too tall for me. i'm generally comfortable on tall bikes but it was too wide
too tall. so back to touratech it went. this is the low and it might be perfect.
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It's raining here
Joined: Oct 2006
Location: Cork, Ireland
Oddometer: 2,984
Dude, the market is sport bikes and cruisers. The normal Joe Blog out there has no interest in big dual sports. He either wants to ride fast, cruise slowly, rip up single track or ride around with a T shirt and a beanie to the nearest bar. Then, there are the guys that want to "look" the part, put the boxes on and set their destination to the 4 star hotel in the mountains via the Starbucks mapping system.
Its the same in every sport or hobby.
A friend of mine hiked the PCT last year. 3000 miles over 6 months. He used bog standard equipment that he picked up off Craigslist. Then you see guys and gals in REI buying the latest, lightest most expensive gear for a car camping weekend. Yes, they are rich or have good credit.
The real hard core ADV riders I meet, and I have had many stay in my house while they are passing through, are using cheap motorcycles, purchased used and not caring a crap about the latest and greatest.
One guy called me from OZ last spring, asked me to get him a KLR. I got it for $1,800, he spent another $500 getting it kitted out and the last I heard he was somewhere in Panama. Can you imagine telling some guy in Starbucks that while he's staring out at his touratech covered BMW.
So, my point here is, we have La possier, who would not dirty his butt sitting on a crappy Suzuki, we have the overlanders, who want nothing more than a DR or a KLR, you have the truck your bike to the trail guys, then all the cruiser, harley, crotch rocket guys, the commuter guys and then you have us, the few who want a do it all bike. Yes, we are a special breed, unfortunately, we are a small voice in the small sea of motorcycles.
We asked and got the big DR, the TDM, the transalp but when it came to putting our money down, the bikes were left on the showroom floors, hence, we never got the new transalp, the Africa Twin, the TDM 900, the Tenere 660. I really hope Triumph make a success of this tiger 800, but already I see and hear of a lot sitting on the floors. Triumph have sold a bunch, but, the dealers have them still...
The speculation on the Tiger before it came out had people worried that they could not make them fast enough.
Any bike maker now, has to make the bike appeal to a wide audience, which is why the strom 1 was a huge hit. The price was the main selling point, bang for the buck. Your not going to see Joe the bus driver riding a $13K tiger to work, or a $10K strom with "wire wheels and upgraded suspension" He wants a decent bike for $7-8K, and, Suzuki will give him just that because there are more Joe's on the planet then Ewans and Charlie's.
So, yes I'm excited about the new bike, but not expecting the holy grail of motorcycles to come off of Suzuki's line.
European bike sales and storage.
Joined: Jan 2009
Location: Cary, North Carolina
Oddometer: 1,620
I picked up the Vee after I watched Ewan and Charlie. I know at least three people who switched from standard and sport bikes after they watched (on my live then blog) TAT ride... Plus my cousin in Kazakhstan... He wants to buy my Vee when I'm ready to upgrade...
I'm not in statistic business, but I met many people who switched from just riding to Adventure riding...
And I'll be disappointed if new Suzuki is smaller than 1000cc... There are trail dirt bikes for it to buy...
2012 Triumph Tiger Explorer
Beastly Adventurer
Joined: Oct 2009
Location: Blue Mnts Ozstralia
Oddometer: 5,424
They woke me up to the fact that, I used to do that on POS when that's all I could afford. The "POS" I had were small Jap twins that I didn't like that much at the time but then I realized that they just ran and ran and ran and never gave me cause to worry much I also realized that the whole faster and faster marketing was just not me.
All good. I hope the segment does well. The V-Strom has its place and it doesn't need to be anything other than reliable, competent enough and good value
"It's better to ride a boring bike than push an interesting one" ... Canuman
"I just may as well admit that my other bikes are toast. I don't ride them. Plain and simple. I didn't want this. It wasn't the plan." - snakebitten
It's raining here
Joined: Oct 2006
Location: Cork, Ireland
Oddometer: 2,984
Suzuki will make another bike for the masses, hopefully better and with a pretttier front than the last one, and, hopefully it will be another sucess.
It will still be a cheap bike though, well, it will have to be.
Now, where the F is it.
As an interesting side topic,while we are waiting for the new strom, someting to share with your friends, click here to see that cars can beat 60 mpg.
European bike sales and storage.
wheatwhacker screwed with this post 06-17-2011 at 10:15 PM
on the road o'dreams
Joined: Jan 2010
Location: Passing ADV Stalkers in California
Oddometer: 6,128
YES .... the dual sport nonsense came later. With the original release of the V-Strom, there was no mention of dual sport or Adventure. In 2002 the Vstrom marketed as "Sport Enduro Tourer" ... but the project leaders at the 2002 intro discouraged any reference to riding the Vstrom in the dirt. I was there. (also, see Burn's comment below ... he was there too)
Here is what John Burns wrote in Motorcyclist about the Vstrom in 2002.
"right, why not appeal to the same set of
fantasies that have made things like Ford Explorers so amazingly
successful? With its relatively light weight and reasonably good
suspension and balance, the V-Strom actually feels like it wouldn't
be too unwieldy off-piste, but in fact Suzuki (American Suzuki, at
least) is careful to not imply in any way, shape, or form that it's a
big dirt bike. Just as well, probably: Just as few sport-utes ever
dirty their tires, it's unlikely that the V-Strom will be a victim of
the type of wanderlust described by its marketeers. What it is,
really, is simply a cosmetic treatment applied to what we used to
refer to as a "standard" bike, an appellation that's sort of the kiss
of death for most buyers: Standard has come to be synonymous with
The Vstrom was conceived and designed by Suzuki Germany as an affordable (and reliable) alternative to the R1150GS. American Suzuki rejected this bike but Japan prevailed and forced it on them. Am Suzuki thought it would be another Yam TDM debacle. They, of course, were wrong.
By the time the Wee Strom came along word was getting back to Japan that many owners were riding their DL1000's off road ... and doing well! Who knew!
The Wee was not originally pushed as a dual sport bike either ... but as a lighter less expensive adventure bike. I think it's success surprised them.
I have attended several Suzuki intros and the Japanese are surprised to hear how and where Vstroms (and especially Wee Stroms) are taken off road ... and around the world.
In the last few years they (finally) picked up on the "Adventure" dual sport idea as a marketing tool. But if you ask directly ... they will tell you neither Vstrom are suitable for off road use. Don't ask anyone at American Suzuki ... ask the Japanese directly. Am. Suzuki workers are peons. The Japanese are master.
Kawasaki not only added a fairing but it appears every single new KLR650 burns oil ... lots of oil My KLR "expert" buddy claims ALL NEW KLR's BURN OIL. I really didn't want to believe this ... but I trust him as he is deeply inside KLR world ... owns three KLR's ... has put 100,000 miles on them.
But don't count BMW OUT yet. They'll be coming back with a revised F800GS. Suzuki's DL650 Strom will continue to sell and the upgrade and Bold New Graphics will help that ... but as others here have noted ... it may not be an enthusiasts bike any longer. There seem to now be several other better choices.
Adv Grifter screwed with this post 06-17-2011 at 10:34 PM
dreaming adventurer
Joined: Nov 2005
Location: right here on my thermarest
Oddometer: 103,027
Are you Django Loco?
Beastly Adventurer
Joined: Oct 2009
Location: Blue Mnts Ozstralia
Oddometer: 5,424
But the big question is. When is Loncin going to release theirs?
I want to see what happens in the BMW forums when that happens.
Just like the Suzuki / Hyosung Spats I assume.
"It's better to ride a boring bike than push an interesting one" ... Canuman
"I just may as well admit that my other bikes are toast. I don't ride them. Plain and simple. I didn't want this. It wasn't the plan." - snakebitten
GrahamD screwed with this post 06-18-2011 at 12:36 AM
Not in the clique...
Joined: Jun 2009
Location: South Central Texas
Oddometer: 10,001
I spent all my money on motorcycles, 4X4's, whiskey, and women...The rest I just wasted. (edited to fit/original phrase by "WIBO")
"There's a WEALTH of cool people and knowledge on ADV, there's also a decent sized pocket of douche bag assholes that think their ADV forum Post Count (Oddometer) is their badge at being experienced riders." goodcat8
Palanquins RTW
Joined: Mar 2007
Location: Carried Forth
Oddometer: 16,335
shine on, you crazy emo diamond
Joined: Jan 2010
Location: KALAMATA GREECE
Oddometer: 21
Wandering Minstrel
Joined: Feb 2007
Location: Dorchester, MA / Goshen, NH
Oddometer: 6,341
But it's not really a cheap bike. There is no better engine at any price. The frame is more than rigid enough. An ABS package that increases weight only 7 lbs is the envy of some other manufacturers.
What tipped me from buying a GS was riding a co-workers. I found the 1200 engine to be a lump: plenty of torque but surprising vibration. The ride, though, was really good. Then I found out that the bike I was riding had a full Ohlins suspension upgrade, adding a couple thousand dollars on top of the bike because BMW doesn't do suspensions like anyone else. He also apologized for a pulsation in the brakes that took BMW over a year and three sets of rotors to fix.
So Suzui in my mind made excellent value engineering choices, not skimping on the excellent engine, transmission and clutch (things we take for granted). The things they did skimp on - bars, forks, shock - are relatively easily and cheaply upgraded. Even the much-maligned rear shock was a decent attempt: not many bikes at the time had remotely adjustable spring preload.
I paid $7,250 for a new 09 DL650A. Added Ricor Intiminators (now $300), an Elka 3-way shock ($1,000 group buy) and Sonic springs ($80). That's $8,630 versus around $10K for the BMW F650GS. To be honest the difference in price wasn't the deciding point.
What may be forgotten is the response of other manufacturers to the V-Strom DL650. While the DL1000 was probably considered a swing and a miss", BMW made their 650 an 800, Triumph passed, and KTM doesn't offer a 650 twin.
A month ago I took a BMW F800ST out for a track session at a CSS school. Was it faster than the DL650? Sure - but not by much. We all appreciate low rpm torque but if you want to get on down the road. the DL650 can get the job done. I took my bike out for a track day so I've seen the difference when riding 10/10ths.
A BMW F800GS does 0-60 in 3.95 sec. and 1/4 mi. in 12.20 sec @ 107mph. BMW F650GS [800cc] 12.53 seconds @ 103.75 mph. Triumph 800 does 0-62 in 3.72sec. and 1/4 m in 12.08 sec. @ ?mph.
The DL650 has logged 0-60 times of right around 4 seconds and Sportrider logged a 1/4mi of 12.52s @ 102.0 mph. And that's why BMW and Triumph passed. Because Suzuki makes a brilliant, smooth, reliable engine in huge numbers at low cost that they can never compete with.
So yes, the 800's are faster, and undoubtedly more responsive passing at 65mph+ heavily loaded. But how often has that been a requirement for any of you? Adventure bikes are all pushing a lot of air at speed so none of them feels very responsive anyway: my SV650S feels like a rocket ship in comparison accelerating at highway speed, with the same motor.
If you are a wise-ass you can ask "Why are BMW and Triumph horsepower so much smaller, even though they cost more?" More to the point, why would Suzuki change? They can update the ingredients without changing the cake, and most importantly to them, sell it at a profit.
So I think the new bike will be very similar in concept to the existing bike, with the same [Gladius] engine/transmission package, similar suspension components, etc. I think they will strip some of the plastic off the front to make it smaller, lighter, and less costly.
Doubt the fuel tank will change capacity much if at all, and if so, will be smaller which will make it cheaper, lighter, and easier to package into a narrow front. The F800GS is 5.3 gal and I think the Triumph is 5 so clearly the market isn't demanding more.
2012 WR250R, 2009 TW200, 2008 Tiger 1050 ABS, 2008 CRF100F
The problem in defense is how far you can go without destroying from within what you are trying to defend from without. ― Dwight D. Eisenhower
Gnarly Adventurer
Joined: Mar 2011
Location: Austin, TX
Oddometer: 200
Sophmore ADV Rider
Joined: Sep 2009
Location: Pacific NW
Oddometer: 44
To Garandman:
You, my friend, nailed it... Suzuki needs to give us an inexpensive do-it-all bike that we can turn into our dream ride with a few modifications, just make sure the basic package is solid, and we can take it from there.
Devin E.
2007 Suzuki DL650 V-Strom
2007 BMW G650 XMoto
1981 Yamaha XS650 Special II
Joined: Jun 2005
Location: Austin, Texas
Oddometer: 271
The BMW R1200GS has had remarkable world-wide success (I believe it's the best selling model in Europe over 1000cc) leading manufacturers like Yamaha and Triumph to seek part of those sales. The sport bike market is down and America (at least) is seeing a dramatic demographic shift with the baby boomers entering their fifties.
So, I am excited to see what Suzuki has in store for the DL650. Like others have stated, I am hoping for more ground clearance, spoke wheels, and a more attractive look. As a former owner, the windshield, suspension, etc. can be fixed.
Grimace Soup
Joined: Oct 2007
Location: Not home in Tijuana
Oddometer: 8,635
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