text:
Lance Cuffley is on LMTmag.com!
Already a member? Log In
LMTmag.com is an online network from LMT dedicated exclusively for members of the Dental Laboratory community. Join free to connect with Lance.
Already a member? Log In
LMTmag.com is an online network from LMT dedicated exclusively for members of the Dental Laboratory community. Join free to connect with Lance.
Looking at the possibility of getting a job in Southern California . Just putting feelers out at the moment . Have had my own lab in South Africa for 17 years specialising in Cr/Co frameworks and have...See more been working for other labs who do their own plastics . Any feedback would be much appreciated .
Lance Cuffley
Hi Lance. It is Jenni From Jiahong Dental Lab. Will you attend the Lab day chicago dental show, is that possible to meet you there. Our Booth NO. is 1505. Thanks!
Hi Tay , thanks for the interest . I would be looking for a job in a lab doing chromework . It's what I know best and what I enjoy doing.
Hi Lance. Are you looking for a job in a lab, or are you open to working for materials companies?
13% of respondents to LMT's 2013 Dentist Survey plan to retire within the next five years. As baby-boomer clients begin to reach retirement age, lab owners need to target younger dentists to ensure a consistent workflow and a dynamic and diverse customer base.
LMT Original Research © 2010 - 2015
84 South Main St., Newtown CT 06470
203-426-4LMT · 203-491-2300 (fax)
LMT Communications delivers the business strategies, information, dental laboratory news and education that dental laboratory decision-makers need to succeed. Through LMT Magazine and our LAB DAY shows, LMT works to advance excellence in dental technology, enhance the products, services and communication of dental technicians, and give dental laboratory owners and managers the tools they need to flourish. Learn More »


text:
Shots Fired By Google in the Yahoo/Firefox Partnership
March 13, 2015
While doing a Google search this morning, I noticed an interesting message from Google above the search results. It said, 'Switch your default search engine to Google.'
Clicking the Learn how button takes you to a page with steps and screenshots showing how to change your default search engine in Firefox.
This is in response to a recent deal between Firefox and Yahoo, where Yahoo replaced Google as Firefox's default search engine. According to reports the change has provided a small boost to Yahoo's already rather small percent of the search market, with Google also loosing 1 percent during the same time.
Whether this is due to actual concerns over loosing customers or just not letting their competition have anything easy is anyone's guess. However, this is not the only time Google has used it's market position to attack their competition. For years, Google has been pushing Google Chrome on Firefox and Internet Explorer users.
Update 03/20/2015: The following adblock element hiding rule seems to work to get rid of it: google.com##DIV#taw
Another Revslider Vulnerability
November 30, 2014
After cleaning up a recent WordPress hack, I believe there is another Revolution Slider vulnerability making the rounds. If you are using an old version of Revoltion slider, you should update immediately or disable the plugin.
From what I can tell, it affects two Themepunch plugins, Revslider and Showbiz Pro. According to a proof-of-concept exploit posted this month, versions 3.0.95 and before of Revslider, as well as versions 1.7.1 and before of Showbiz Pro are vulnerable.
The issue allows for unauthenticated ajax calls sent /wp-admin/admin-ajax.php to trigger Revolution Slider's onAjaxAction function, which in turn can be used to delete slides, import/export slides, and update the plugin(among other tasks.) In the case of the site I cleaned up, they used it to trigger an update to the plugin, which uploaded a remote shell to the site.
From looking around, this vulnerability appears to have been posted relatively recently on several sites and is currently being exploited.
The Vulnerability
This is part of revslider_admin.php. In affected versions, the below gets called, which adds wp_ajax and wp_ajax_nopriv callbacks for the onAjaxAction function.
Since there is no check on whether the user is actually logged in or allowed to make changes to the plugin, it is possible to(among other things) upload files to the server.
self::addActionAjax("ajax_action", "onAjaxAction");
This in turn calls the addActionAjax function, which creates the wp_ajax and wp_ajax_nopriv callbacks.
protected static function addActionAjax($ajaxAction,$eventFunction){ self::addAction('wp_ajax_'.self::$dir_plugin."_".$ajaxAction, $eventFunction); self::addAction('wp_ajax_nopriv_'.self::$dir_plugin."_".$ajaxAction, $eventFunction); }
As a result of this, the revslider_ajax_action action gets added, allowing for unprivileged updates. This is not terribly surprising as, at least in early versions of Revolution Slider, security and a deep understanding of wordpress do not seem to have been a concern.
Working Example
The following is a working example. On a vulnerable site, the following will print an ajax response similar to: {"success":false,"message":"wrong ajax action: asdf "}.
If you see something to the effect of {"success":false,"message":"Wrong request"}, you are probably not vulnerable, but should still verify you are running the most recent version, as there are several known vulnerabilities at this point!
<form method='post' action='/wp-admin/admin-ajax.php'> <input type='hidden' name='data' value='asdf' /> <input type='hidden' name='client_action' value='asdf' /> <input type='hidden' name='action' value='revslider_ajax_action' /> <input type='submit' /> </form>
The reason you see this response is because the switch is called and since asdf is not a recognized action, it triggers the default: self::ajaxResponseError("wrong ajax action: $action ");
Affected Versions
As stated above, this does not appear to impact newer versions 3.0.95 of revolution slider, as well as versions 1.7.1 and below of Showbiz Pro.
In a newer version I checked, Themepunch appears to have added a nonce called revslider_actions and check that the nonce is present in onAjaxAction prior to actually executing the ajax calls.
Temporary Fix
If you are using an old version of revolution slider, you should update immediately and/or disable the plugin.
As stated before, since this plugin is often included with themes and is a premium plugin, updating it presents several difficulties and is something that a non-tech website owner might not even know they need to do. I feel this leaves something to be desired.
The below should be a quick way to stop the attack.
**Note that the below will only allow people with the privilege to install plugins to work with Revslider's Ajax calls. You may want to adjust what permission you allow.
public static function onAjaxAction(){ if(!function_exists('current_user_can') || !current_user_can('install_plugins')){ exit; }
Given that there have been two very serious vulnerabilities reported in the past few months, I would strongly encourage you to upgrade the plugin to the latest version and/or use a different plugin!
Yesterday, a vulnerability in an old version of Revolution Slider was reported. The vulnerability allows visitors to view arbitrary files on the web server, like wp-config.php, without being logged in. All you need to view any file on the server is to know the location of the file and for the web-server user to have permission to view it.
According to ThemePunch, the plugin developer, the vulnerability was patched 29 versions ago in February, but they decided not to publicize the severity of the issue, aside from a single 'fixed security issue' line in their change log. This was because:
"[We were] told not to make the exploit public by several security companies so that the instructions of how to hack the slider will not appear on the web."
As a result of this negligence and the way that Revolution Slider is Updated and bundled with themes, this simply left any website not running a recent version of Revolution Slider vulnerable for months to an extremely serious file inclusion vulnerability.
Its Your Fault For Not Updating
This seems to be the company line for this issue. After the vulnerability was made public, they have stated:
"You should always keep the slider up to date like any other WordPress component but urgently need to do this when using Version 4.1.4 or below in order to fix the security issue. […] We are sorry for you guys out there whose slider came bundled with a theme and the theme author did not update the slider. Since you cannot use the included autoupdate function please contact your theme author and inform him about his failure!"
And it is true, you should keep your plugins updated.
However, this is a paid plugin and doesn't allow easy updates like a normal wordpress plugin does. Further, on all of the sites I fixed, they didn't appear to have a nag telling the user an update was available from the backend. So, unless you are a developer and actively visited the plugin's website, you wouldn't even know the plugin needs to be updated, let alone an extremely serious security vulnerability.
As they mention, they sell a developer license that allows developers to include the plugin in their theme. When the plugin is included with themes, you can't update it without updating the theme. So, any theme that isn't regularly updated is at risk. And, since some shoddy developers edit the theme directly, rather than making a proper child theme, it isn't always easy to update the theme. This, of course, isn't the fault of ThemePunch, nor is it good practices to develop like this, but it does happen and is going to be a legitimate problem for people.
Even if you actually have the premium plugin itself, you can't just update it. There is no auto-update feature(at least not in the vulnerable versions I saw,) so you can't update it like you would a regular WordPress plugin. Nor, to my knowledge, is there an update nag on the plugin page telling users they need to update. Instead, you need to download the premium plugin, which requires a login to the site that sells it.
The catch here is that most website owners aren't going to have access to the login information needed to update the plugin. Your average website owner isn't a developer. They probably paid someone to create the theme, who presumably installed a valid copy of the plugin. Unfortunately due to the nature of web design, this simply means that hundreds(thousands?) of sites are silently vulnerable to an extremely serious vulnerability and won't even know it, unless they have a responsible web developer or host. Again, this isn't the fault of ThemePunch, but is a fault with the premium plugin model when it doesn't allow for quick/easy updates.
Negligence Through Security Through Obscurity
According to the plugin author, this vulnerability was fixed in February, but they chose not to report it. It has been reported that this vulnerability was publicly disclosed months ago and regardless, it is safe to say that it was known by some people for the past few months.
By choosing not to report the vulnerability and making site owners aware of this huge security risk, they effectively pushed back the date where we found out about it leaving their customer's sites vulnerable to a known attack. And, now that is is released and being exploited like mad, we are left scrambling to fix it anyway. So, not reporting it only helped the bad guys.
I understand fully that this is a paid plugin and the need for them to protect it. I get that. And, I understand that you should keep your plugins updated. Nothing in their statements that I have seen is untrue.
However, in the event of a serious vulnerability like this, not making a valid attempt at reporting it, especially when you know that your plugin doesn't get updated frequently and the vulnerability likely impacts a large number of sites, is negligent.
Updating a Plugin You Can't Update
I don't use this plugin on WordPress templates I develop, but it is used by several clients that I host. I found it bundled in two client's themes and installed as a plugin for two other clients. All 4 had their wp-config.php file downloaded already and all sites on my servers have been scanned for this vulnerability already.
I wrote a quick and dirty patch for the outputImage function, which you can view here. This is only meant as a temporary fix, until you can assess the issue and do a proper update, but since this attack is ongoing and widespread, you should take some sort of action asap.
Mod_Security also appears to block the attack.
If you have visited windows.microsoft.com lately using Internet Explorer 7, you would probably see the "It's time to upgrade your browser" nag, which explains that IE7 and IE6 no longer supported and blocks you from browsing their site until you upgrade.
This is a great step, as even with XP support going away, Vista shipped with Internet Explorer 7, so it will not be dead for some time. When they first started doing this on the Windows site, I thought it was cool that they were finally doing something to clean up the mess they created with their fragmented browser ecosystem.
However, Internet Explorer 8 is still a pretty bad browser…certainly better than IE7, but that isn't saying much.
If you are going to break your website to force an upgrade, it would be great to use that as a platform to get them into the latest version of Internet Explorer that you can. So, if they are on Vista, go ahead and tell them to upgrade to IE9. Better yet, go ahead and add an optional tool they can use to verify automatic updates is on and set to update automatically, as if they are running IE7, they may not be getting security updates either. And, if they are on IE8, go ahead and add a nag for that too! Although, I think that one may be trickier, as in a in corporate environments, upgrading past Internet Explorer 8 may not be possible. So, rather then fully breaking the site, probably a nice warning would suffice. Be a nice kick in the butt for companies that haven't upgraded yet as well.
This seems like the right thing to do, especially as dropping support for IE8 has already begun on a number of popular websites. Even Microsoft's Office 365 has recently announced they are no longer supporting IE8.
Runs Linux: Sprint Customer Support(???)
February 13, 2014
I recently had a computer repair for someone who needed me to downgrade Windows 8 to Windows 7, because Windows 8 was not compatible with their work software. For anyone that hasn't done it, UFI can make this process a bit tricky, as access to the Bios can be limited and booting to removable media troublesome.
When I returned to their house, I did the basic setup and familiarization with them, to make sure they were comfortable with how everything worked, discuss anti-virus, some of the tools I pre-install when I do a Windows re-installation.
They wanted to run their work software while I was still there and I got a pleasant surprise when they booted up an Ubuntu based Live CD.
The company they work for is through Arise, which offers virtual call centers. They were in the process of training to work with Sprint, so I am not 100% sure how the process is after training. However, since they are training on a Linux Live environment, I would be surprised if they didn't use that for actual work as well.
I didn't do anything aside from making sure it would boot, but it looked like a very minimal Gnome Install, possibly Gnome 2 or at least classic shell. There were only icons for Firefox, a calculator, and an icon for some minimal settings. It utlized a bootable USB alongside a CD.
I thought this was really cool and a great idea. Linux runs great on most hardware and you can get awesome performance out of older hardware, where Windows would be slow once you started doing any real work.
Using a Live CD is also much more secure, like using a Live CD for your banking, as every-time you restart, it should be to a known-good operating system and programs. I would imagine this also gives the company a lot more control and monitoring capabilities, which they wouldn't have if they let people run their personal computers. Since so many people's personal computers have some form of Spyware or Malware, I see this as a no-brainer for companies that have these sorts of remote operations.
Not all companies do this though, I have worked on the computer of someone who worked for American Airlines before. He had worked for American for a while as a call center rep and took the opportunity to work from home when they offered it to him a few years ago. As far as I could tell, there wasn't any sort of required anti-virus and very little over-site to what was running on the person's computer, aside from running American's call center software. Pretty scary when you think about how often their call center reps probably deal with credit card information and other confidential email during the day.
Softlayer CloudLayer vs Amazon AWS: Which is More Reliable?
January 15, 2014
While viewing Softlayer's Website today, I noticed something rather amusing…they are using Amazon's Cloudfront to deliver at least one script on their homepage.
Softlayer is a hosting company, which does a lot of dedicated hosting. However, especially since being acquired by IBM, they have been heavily promoting the cloud side of their business. So, it is sort of funny that they are using their biggest competitors service on the homepage of their website to serve up javascript, rather then their own Cloudlayer or other infrastructure.
Of course, you should use what works, works well, and is easy, which in many cases is an offering by Amazon AWS. However, if your goal is to 'to Accelerate Adoption of Cloud Computing in the Enterprise,' you should probably keep your hosting in-house as much as possible and not showcase the reliability and reach of your competitor.
As an aside, this reminds of a similar situation a few years ago when Dreamhost was having some major downtime. I noticed that the Dreamhost status blog was always up, despite probably getting crazy traffic from all of their customers, while their shared hosting hosting infrastructure was seeming to crumble. I checked and saw they were using Linode to power their status blog, still do. That ended up being a good recommendation, as I switched to Linode shortly after that and have been overall happy with them ;)
XFCE Resolution Resetting and Ignoring Xorg.conf
December 7, 2013
See bottom of post, for the TLDR problem/solution:
I have been using XFCE for some time now and overall really enjoy it. I switched to XFCE after giving Gnome 3 a go when it first came out and have been using it since. It has gotten a lot better since then too.
For instance immediately after switching, one of the only things I missed from Gnome2 was tabbed file browsing. Thunar, the default file manager for XFCE, got that awhile ago and has generally been improving a lot.
Another change to XFCE is the way it remembers your desktop settings, windows, and programs when you logout. I admittedly have not researched this as much as I should, but anecdotally I noticed some changes to how this works when I upgraded to a newer version of XFCE recently. I also noticed that there seems to have been a change with the way that XFCE deals with multiple monitors, as after upgrading certain programs starting using the entire width of two monitors when initially drawing their windows, rather then using a single monitor as they had in the past.
Onto the problem: After getting new monitor that supported a higher resolution(1920×1080) and updating my xorg.conf, my resolution would get reset to my old resolution(1680×1050) as soon as I logged back in to XFCE.
I use Nvidia drivers, as I have found them to offer a bit better performance and support for a multi-monitor setup, not to mention generally quite easy to configure. Its been awhile since I tried using it, but the built-in display manager for XFCE has not been well suited to using multiple monitors in the past, while using nvidia-settings provides a nice easy to use GUI for arranging and setting up displays.
I tried several different things with my xorg.conf and nvidia-settings, including removing it all together, as well as a variety of different configurations. However, no matter what I had in my xorg.conf, as soon as I logged in the resolution was reset to the old resolution. It seemed like XFCE was ignoring my xorg.conf settings or overriding them.
I was fairly confident that the xorg.conf was correct, so I began looking elsewhere. I grepped my ~/.config folder for my old resolution and did in fact find it listed the old resolution in: xfce4/xfconf/xfce-perchannel-xml/displays.xml.
I tried changing it there to the new resolution, however it still reverted back to the old one. Finally, after being a bit fed up and fairly confident that the saved settings/sessions were to blame, I moved my config folder to a backup: mv ~/.config ~/.config_back
This unfortunately has the side effect of clearing all(or most) of your saved XFCE settings, but as soon as I did that, it started using the new resolution. I have in the past done some messing with xrandr settings in order to get multi-monitors working better, so it is possible this is my own doing, but there was definitely some xfce setting in my config that was reverting the resolution.
This is something that I should learn more about and rtfm a bit, but sometimes killing it with fire works and is the easiest/quickest solution…
Problem: After getting a new monitor, the resolution specified in Xorg.conf was ignored when logging in to XFCE. Instead, each time I logged in, it reverted to the old resolution.
Bad Solution: This is probably not the best way to address the problem. However, moving ~/.config to ~/.config_back cleared out whatever xfce setting was over-riding my xorg.conf and let me use the new resolution.
Caution: Again, this isn't a good solution, but it worked. If you do the above, it WILL delete all of your XFCE settings, like panels! A better solution would be to learn why/where that setting that maintains old resolution is kept and changing it!

subset: commoncrawl


text:
Tickets for the Hawaii Bowl
- The Big Story
A Bowl Win Would Mean Everything To ECU
2006 CFN Hawaii
Bowl Preview
WhatIfSports.com New Mexico Bowl
Prediction & Box Score
2007 Hawaii Bowl
History, Each Team's Best Bowl Moments, & More
About a month ago, Boise State was thinking about a
return trip to a BCS bowl game, while East Carolina had its sights
fixed on the Liberty Bowl and a Conference USA championship.
Instead, they'll meet in Honolulu with an opportunity to soak in one
of the prettiest bowl venues, and end the season on a high note.
Last year's postseason darlings for beating Oklahoma in the Fiesta
Bowl, Boise State passed on a chance to host Georgia Tech in the
Humanitarian Bowl, opting instead to take its product off the
mainland. Ironically, the Broncos will be returning to the scene of
a Nov. 23 loss to Hawaii that ended any dreams of a repeat
appearance in a big-money, January bowl game.
Considering the turnover at some key spots from last season's
perfect squad, Boise State has done well to get back to 10 wins for
the seventh time in the last nine years. A lot of the credit
belongs to senior QB Taylor Tharp, who's proven to be a solid
successor to Jared Zabransky, and a fine one-year solution in a
system that requires the quarterback to distribute the ball without
making mistakes. After starting slowly, Tharp carried a program
that was without star RB Ian Johnson for a time, throwing for more
than 3,000 yards and 28 touchdowns, getting picked just nine times.
Long before kickoff, the school got its first big win of December
when coveted head coach Chris Peterson made it clear he plans on
staying at Boise State for the foreseeable future.
The East Division of Conference USA was there for the taking before
East Carolina squandered control of its own destiny with an
inexcusable loss to 1-8 Marshall. The same UCF team that ECU
throttled in October went on to win the division and the league,
leaving the Pirates to make the longest trek of any of this year's
64 bowl participants. On a more positive note, the school is
playing in back-to-back bowl games, a sign that it's making progress
under third-year head coach Skip Holtz. East Carolina has a
game-breaking Johnson of its own, RB Chris Johnson, the nation's
leader in all-purpose yards, and one of the fastest players in the
country. Whether he's taking a handoff, catching a pass, or
fielding a kick, the senior is a threat to go the distance with even
a hint of daylight.
Both schools fully expected to be playing in higher
profile games this postseason, meaning whichever one can maintain
its focus with paradise in the backdrop is likely to leave the
islands with a well-deserved victory.
Players to watch: Holtz has had success using two
quarterbacks, strong-armed Rob Kass and the more athletic
Patrick Pinkney. Combined, they've tossed 19 touchdown passes,
despite having access to a pedestrian corps of receivers.
Success through the air, however, won't be easy against a WAC-best
pass defense that's built around two of the league's premier
defensive backs, safety Marty Tadman and corner Kyle
Wilson. Tadman and Wilson rate a huge edge over any receiver
that'll run patterns for East Carolina, meaning it'll again be up to
Johnson to shoulder the load, even though everyone in blue and
orange has been instructed to not let No. 5 beat them with big
The best game within a game, by far, pits a talented Boise State
offensive line versus an East Carolina defensive line that boasts
the size and depth of some ACC programs. The Broncos are determined
to reestablish Johnson and a running game that's slipped
considerably from last year, when the run set up the pass. Paving
the way will be LT Ryan Clady, a 6-6, 320-pound All-American,
who makes NFL scouts gush about his quick feet and agility from a
kid that's so enormous. Clady, G Tad Miller, C Jeff
Cavender will get a challenge up front from a unit that's been
stout all year. The headliners are ends C.J. Wilson and
Zack Slate, who've combined for 21 tackles for loss and 10.5
Boise State will win if... it controls the line of scrimmage.
If the Broncos create seams for Johnson to get to the second level,
they'll destroy an East Carolina defense that's thin and weak in the
back seven. If Johnson reverts back to his sophomore form,
Tharp, even without WR Jeremy Childs, who will miss the game after
violating team rules, will have a field day against a Pirate pass
defense that ranks 115th nationally, and has given up 24 touchdown
passes. While the Broncos only scored 27 points the last time we
saw them, don't forget that in the previous seven games, they
reached 40 points six times.
East Carolina will win if...
dominates the turnover battle. Other than Johnson completely taking
over the game, the Pirates' best chance for the upset is to generate
takeaways, something they've been good at all year. East Carolina
is No. 6 in the country in turnover margin, and when it's successful
in this area, it usually picks up a win. In a game against a
decidedly better opponent, the Pirates need their defensive backs to
end drives, and their defense to create as many short field
opportunities as possible. If East Carolina isn't +2 or better in
turnovers, it'll lose this game by double digits.
What will happen:
Count on there to be plenty of points and plenty of big plays from
backs named Johnson. Playing the hunter instead of the hunted this
postseason, it might take a quarter or even a half before Boise
State realizes it's a substantially better football team than East
Carolina. The Pirates' season-long struggles with good offenses
will continue, with Tharp connecting with Childs on a couple of
touchdown passes, and Ian Johnson deliveing his best production
since the Oct. 14 marathon win over Nevada.
Line: Boise State -10.5 ... CFN Prediction: Boise
State 38 ... East Carolina 24
2007 Hawaii Bowl
History, Each Team's Best Bowl Moments, & More


text:
Originally written on Fox Sports Tennessee | Last updated 8/18/12
CINCINNATI (AP) -- Johnny Cueto knows how to prepare for day games, and his routine is working out quite well for him. Cueto pitched eight crisp innings, Todd Frazier hit a go-ahead homer for the second straight game and the Cincinnati Reds beat the Chicago Cubs 5-3 on Saturday in the opener of a day-night doubleheader. "Don't get me wrong," Cueto said through an interpreter after improving to 11-0 with a 1.62 ERA in 13 day games this season. "I like throwing at night, but I like pitching in the day, too. It's not really different. It's all in how I get prepared the night before day games." Xavier Paul and Miguel Cairo added their first home runs of the season as the Reds roughed up another Chicago starting pitcher for three home runs. They hit three off Travis Wood in a 7-3 win on Friday night and three more off Jeff Samardzija. Cueto (16-6) settled down after allowing Alfonso Soriano's two-run homer in the first. The right-hander gave up three hits and struck out eight, drawin...
Comments are closed.
What do you think?To leave a comment, you can:
MLB News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
Follow us on Twitter
|Best of Yardbarker
|NFL News
|MLB News
Today's Best Stuff
For Bloggers
Join the Yardbarker Network for more promotion, traffic, and money.
Company Info
What is Yardbarker?
Yardbarker is the largest network of sports blogs and pro athlete blogs on the web. This site is the hub of the Yardbarker Network, where our editors and algorithms curate the best sports content from our network and beyond.
|© 2015 Yardbarker, Inc. All rights reserved. Use of this website (including any and all parts and components) constitutes your acceptance of these Terms of Use and Privacy Policy. (What's New?)


text:
Firing & Layoffs
Why Every Small Business Owner Should Have Job Descriptions
5 steps to writing one for you, and your staff
How to Deal With Toxic Employees
A staff member's negative attitudes are particularly harmful to small businesses. Our checklist helps you nip bad behavior in...
VIDEO: Firing an Employee? Follow These Tips.
Letting an employee go is never easy. But our 5 tips on mistakes to avoid during the process can make it a bit easier to handle.
Escaping a Creative Rut
Small business owners should ask themselves tough questions to gain fresh insights.
View More Business Resources
Liar, Liar, Résumé on Fire
Is a potential job candidate lying to you? Learn how to spot lies in résumés.
3 Tips for Letting Employees Go as Painlessly as Possible
Firing is never fun. Here's how employers can let an employee go with dignity.


text:
Alabama A&M Bulldogs at Mississippi Valley State Delta Devils Basketball
Wed, Feb 6, 2013 7:30 pm
Harrison HPER Complex, Itta Bena, MS
Sorry, this event has already taken place. Please see similar events below.
|Tweet | State Guides | Gift Certificates | Policies | Blog | About Us | TicketMasters sold out |


text:
my Nutrition
my Fitness
Other Goals
my SparkPoints
Web Search
Articles & Videos Home
Health & Wellness
Health A-Z
Cold & Flu
GERD (Heartburn)
Healthy Heart
High Blood Pressure
High Cholesterol
Irritable Bowel Syndrome (IBS)
Pain Management
Seasonal Allergies
Weight Loss
Pregnancy & Family
Instant Inspiration
Lifestyle Centers
Beauty & Style
Brides To-Be
Family Wellness
Healthy Home
Pet Health
Senior Health
The SparkPeople Blog
Community Home
Message Boards
Challenge Central
Member Blogs
Friend Feed
Advertisement --
Learn more
about ads on this site.
Tuesday, Week 5
View FORMYDARLINGS's Sparkpage
View All Blog Entries from FORMYDARLINGS
Tuesday, June 05, 2012
Time to assess where I am on this journey. Well, it seems I haven't kept up my walking. Have not been out since Thursday of last week. I went back out this evening and while I was only able to do 10 minutes. I did so happily. That is not always the case. DDH went with me. Not much of an adventure for him though as he can walk for miles. Such strong legs. I am jealous. I will keep myself going out every day. Mom and I are going clothes shopping tomorrow so I will get a walk in with that. I don't like clothes shopping right now as I need a 4x or 28 and I have only 1 shop I can go to. I won't be getting very much, but with donating, in error, my summer clothes last fall, I have to get something to wear.
The poor dog comes with us on our walks. Either DS or DH goes with me each time. What good boys they are. Probably expecting me to have a heart attack while I am out.Back to the dog. She is prancing and happy for the first 4 minutes and then realizes we are not going to stand on the lawn for as long as she wants and then go inside. By the time we get back, her ole tongue is hanging out of her mouth and she is breathing as hard as me. Part of our walk, the first 2 minutes infact, is uphill. It is a long grade but pretty steep. She always forgets that is where we are going. Poor doggy. She'll get fitter too.
I tossed out bottles in the living room again today, 30 of them, and bent and picked up all of them. Took me forever. I was huffing and puffing when that was done. But it serves a purpose. I must add that both DS and DH think it is madness.
My new deep freezer came today. It is much bigger than I thought, we bought it online and the picture was little. There is a sheet with it that says it only uses about $$66 worth of energy a year, so the landlords are happy and so am I. I like to conserve energy. ( mine and Hydro's ) LOL
We shop often and see so many good deals but had nowhere to store the products. It is especially true for meats and poultry. I also like to cook recipes that make more servings than we need and freeze some. However, now that beans are a staple of our diet, I am finding that many of the recipes on SPark, make 10 -16 servings each. As I don't like to eat the same thing twice in a week. and we were planning to make 3 recipes per week, we discovered that we would soon be overcrowded with leftover bean dishes. I have to rethink what I should do about this. It doesn't make sense to cut the recipe down as most recipes call for cans of beans and what to do with the other 1/2 can? Conundrum!
I weighed in on Monday and although I did lose 1 lb, I was disappointed. I thought I would lose more than that. I have so much to lose that it is discouraging to go sooo slow.
We are going away with friends during the week next week. We all go to 1 couples house and visit their town. It is in Niagara Falls and there is lots to see and do. Usually we go to The Shaw Festival, and see a couple of plays. This year I had to opt out of the plays as I am too big to fit into the theatre seats. This is a goal to work towards for next year at this time. We spend a lot of time walking around town and it is very hard for me. I have to sit down about every 10 or 15 minutes. DH and I walk and shop alone so no one else is held back. Besides, all my girlfriends shop for clothes and it is depressing for me to just waddle and watch. I will be taking most of my own food so that there will be something for me at each meal. Friday night we go out to dinner. I hope the menu includes lots of salads and chicken or fish. I can't have shellfish right now so am hoping for a good fish entr�e'.
My goal this week is to walk as far as I can every day and to put my shoes on first thing in the morning to count ALL my steps. Usually I don't get my shoes on unless I am going out, and my pedometer is on my shoe. I am still doing pretty good with my water but this week I am going to put in a more concentrated effort to drink more water than diet soda.
That's it for today. Hope you are all healthy and strong and are working to stay that way.
Report Inappropriate Blog
Member Comments About This Blog Post:
I have to go through my bins to see what I can get on my "free shopping trip"" I have a lot of stuff that is too small that I have been saving
Report Inappropriate Comment
Gini, you are being honest with yourself which is very important!!! Keep at it! And one pound is one pound! Be proud of it!
Report Inappropriate Comment
Hi friend, I'm glad you are reassessing your progress and setting new goals. I find that I have to do that all the time, I set a goal but the progress is slow, I miss the deadline then have to set a new goal. By the way, one thing that has really helped me is being able to eat the same recipe an entire week! I actually don't mind it and sometimes look forward to it. Basically I cook something on Sunday and make enough to last till Friday and everyday I pack lunch to work and when I come back home I eat the same thing. But the freezer approach is a great idea since you prefer not to have the same recipe twice in the same week. You can do it!
Report Inappropriate Comment
It may seem slow but for now, it is still a step in the right
direction. I think the water bottle exercise makes good
sense even if the men in your life think its madness. No,
it's movement and it means you are trying. Just keep
up with what you are doing. HUGS!
Report Inappropriate Comment
Add Your Comment to the Blog Post
Log in
to post a comment.
Advertisement --
Learn more
about ads on this site.
Get An Email Alert Each Time FORMYDARLINGS Posts
Other Entries by FORMYDARLINGS
Setting some new more reasonable Goals
- 6/20/2015
How long have I been sidelined?
- 5/24/2015
Taking Control
- 3/22/2015
Moving from one day to the next
- 3/4/2015
View All Entries


text:
Summary: Essentials Of Public Speaking is a value-priced textbook for your public speaking course that teaches students the essential skills and theories required to become an effective public speaker. In addition to being a value, this text offers abundant practical advice on the speechmaking process, grounded in classical and contemporary theory and in a familiar format to instructors. Included in this coverage is a strong emphasis on visual aids and using the Internet for speech preparation and delivery. ...show moreSummary: Essentials Of Public Speaking is a value-priced textbook for your public speaking course that teaches students the essential skills and theories required to become an effective public speaker. In addition to being a value, this text offers abundant practical advice on the speechmaking process, grounded in classical and contemporary theory and in a familiar format to instructors. Included in this coverage is a strong emphasis on visual aids and using the Internet for speech preparation and delivery. ...show less
Preface 1 Foundations Chapter 1 Public Speaking, Ethics, and You Public Speaking: What Roles Can It Play in Your Life? The Right Speech for the Occasion The Communication Process and the Public Speaker Ethics: The Public Speaker's Obligation Chapter 2 Getting Started: Your First Speech Becoming a Good Public Speaker Steps to Success: Planning and Preparing a Speech Chapter 3 Building Speaker Confidence Understanding Anxiety Managing Situational Anxiety Managing Trait Anxiety: Positive Imagery Other Methods for Managing Trait Anxiety Chapter 4 Listening: What Speakers Should Know Stages of Listening Why Stimulation and Motivation Are So Necessary 100 Percent Communication: A Listening Myth How Listeners Avoid Being Persuaded Reading Listeners' Nonverbal Cues Making Listening Easier 2 Preparing Your Speech Chapter 5 Analyzing Your Audience Analyzing Your Audience: Situational Information Analyzing Your Audience: Demographic Information Analyzing Your Audience: Psychological Information Analyzing Audience Receptivity Collecting Audience Information Using Audience Analysis Chapter 6 Selecting and Researching Your Topic Selecting Your Topic, Purpose, and Main Points Researching Your Topic Chapter 7 Supporting Your Ideas Supports That Are Overused--Use Them with Care! Supports That Are Underused--Use Them More Often Supporting Materials: Clarification or Proof Chapter 8 Organizing Your Speech: Introduction, Body, and Conclusion Organizing the Body of Your Speech Organizing the Introduction of Your Speech Organizing the Conclusion of Your Speech Chapter 9 Outlines, Storyboards, and Speaking Notes Outlining Storyboarding Speaking Notes 3 Presenting Your Speech Chapter 10 Preparing Effective Visual Aids Benefits of Using Visual Aids Types of Visual Aids Selecting Your Visual Aids Designing Your Visual Aids Chapter 11 Delivering Your Message Visual Delivery Vocal Delivery Verbal Delivery Immediacy Behaviors Methods of Delivery Rehearsing Your Speech Chapter 12 Perfecting Language Style Why Language Choices Are So Important Effective Language Style Stylistic Devices Language and Bias 4 Types of Speeches Chapter 13 Informative Speaking Types of Informative Speeches Steps in Preparing an Informative Speech Before You Speak: Last-Minute Checks Chapter 14 Persuasive Speaking Persuasion Defined Persuasive Versus Informative Speeches Types of Persuasive Speeches Steps in Preparing a Persuasive Speech Using the Motivated Sequence Chapter 15 Methods of Persuasion Using Evidence and Logic Skillfully Establishing Credibility Appealing to Listeners' Psychological Needs Notes Glossary Index
Advantage Series-Essentials of Public Speaking - 4 edition
Free ShippingGet Free Shipping on orders over $25 (not including Rental and Marketplace). Order arrives in 5-10 business days.
Need it faster?We offer fast, flat-rate expedited shipping options.
Take advantage of Guaranteed Cash Back. Send your book to us in good condition before the end of the buyback period, we'll send YOU a check, and you'll pay less for your textbooks!
When you're done with this book, sell it back to Textbooks.com. In addition to the best possible buyback price, you'll get an extra 10% cash back just for being a customer.
We buy good-condition used textbooks year 'round, 24/7. No matter where you bought it, Textbooks.com will buy your textbooks for the most cash.
Being online is not required for reading an eTextbook after successfully downloading it. You must only be connected to the Internet duringthe download process.
Minimum Requirements:
What is the Marketplace?It's another way for you to get the right price on the books you need. We approved every Marketplace vendor to sell their books on Textbooks.com, so you know they're all reliable.
What are Marketplace shipping options?Marketplace items do not qualify for free shipping. When ordering from the Marketplace, please specify whether you want the seller to send your book Standard ($3.99/item) or Express ($6.99/item). To get free shipping over $25, just order directly from Textbooks.com instead of through the Marketplace.
FREE UPS 2nd Day Air Terms


text:
The Debaters | Season 2011, Episode 18 | Oct 11, 2011 | 22:27
Is Cirque du Soleil the greatest show on earth? | Should we all "Do It Yourself?" (Debates)
Do it Yourself. It's true that self reliance is a good thing, but when it comes to home repair, is DIY really such a good idea? Cirque du Soleil: is it the greatest show on earth?


text:
The misuse of economic history: flawed analogies with Japan's "liquidity trap" and the great depression.: An article from: The Cato Journal
This digital document is an article from The Cato Journal, published by Cato Institute on September 22, 2009. The length of the article is 6167 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.Citation DetailsTitle: The misuse of economic history: flawed analogies with Japan's "liquidity trap" and the great depression.Author: Alan ReynoldsPublication: The Cato Journal (Magazine/Journal)Date: September 22, 2009Publisher: Cato InstituteVolume: 29 Issue: 3 Page: 567(19)Distributed by Gale, a part of Cengage Learning
Please visit Help Page for Questions
regarding ISBN / ISBN-10 / ISBN10, ISBN-13 / ISBN13, EAN / EAN-13, and Amazon
Home | ISBN Directory | Affiliate
Program | Contact
Copyright © 2003-2014 AllDiscountBooks.net All rights reserved.


text:
Morin receives PSU's Distinguished Operating Staff Award for 2014
PLYMOUTH — A longtime Plymouth State University Administrative Assistant described as 'hard-working and dedicated,' was named the PSU's 2014 Distinguished Operating Staff Award recipient at a May 15 campus ceremony. Daphne Morin of Lamson Learning Commons was chosen from a field of five semi-finalists for the annual award.
The award was presented to Morin by PSU President Sara Jayne Steen. When asked about Morin Steen stated that she is a well-respected, popular employee who received glowing recommendations due to her knowledge of the University and work ethic.
"She's described as the glue that holds things together in the Lamson Learning Commons," Steen said. "People talk about all of the enormous work she has done, both personally and professionally. She is a both a leader and cheerleader, keeping communication flowing."
Morin, a Plymouth State employee since 1993, was nominated by her co-workers, who wrote in their recommendations, "she spends an incredible amount of time serving others in Lamson and around campus...she is adaptable, and can answer any question, from the major, overarching structural issue down to where you can find a Phillips head screwdriver."
She is a Bridgewater native and a first-generation college graduate; she earned a bachelor's in Communication Studies from PSU in 2012. She also donates a decorated tree annually for Plymouth's Festival of Trees fundraiser.
Morin said she was surprised when she was announced as the winner of this year's Distinguished Operating Staff award. "I'm amazed, this is such a surprise," said Morin. "It's a wonderful tribute that my co-workers have acknowledged me with this award and I appreciate that."
CAPTION — Daphne Morin, left, of Bridgewater accepts the 2014 Plymouth State University Distinguished Operating Staff Award from PSU President Sara Jayne Steen. (Courtesy photo)
Last Updated on Friday, 30 May 2014 09:29
Hits: 97
Jackie Bonafide photography at the Belknap Mill
LACONIA — The Belknap Mill will host an exhibit of the photography of Jackie Bonafide during the month of June.
Bonafide is looking forward to the June exhibit and sharing her "Discovery" photographs. A reception to celebrate the opening of the exhibit will be held on Wednesday, June 4 from 5-7 p.m.
The exhibit will be at the mill from June 2 through June 30. Regular gallery hours are Monday through Friday 9 a.m. to 5 p.m. and Saturday & Sunday 10 a.m. to 2 p.m.
Bonafide is a photographer who specializes in nature. Growing up on Long Island, NY, she spent childhood summers on Silver Lake in Madison, where her grandparents instilled in her a great love and reverence for nature. She earned a B.A. in Studio Art (focusing on photography) at Newton College, Newton, MA, and later a M.Ed. in English Education/Teaching Writing at Plymouth State College. She has been a New Hampshire resident since 1973.
She and her husband, Phil, raised two sons, Chris and Mike, in Sanbornton. She spent many years working in public relations for nonprofit organizations as well as in development and institutional advancement. She worked as an independent consultant and later held full-time positions with Tilton School, the New Hampshire Writers Project, Community Health & Hospice (now Central New Hampshire VNA), and the New Hampshire Veterans Home.
She began taking pictures when she was old enough to hold and aim a camera. She always carries at least one camera with her everywhere she goes and is committed to "taking nature pictures naturally"—with no artificial manipulation of the image. She explores lakes and takes pictures from her kayak in summer and follows animal tracks in winter.
Her photographs are in permanent collections at: The New Hampshire Veterans Home in Tilton; Lakes Region General Hospital in Laconia,; the Taylor Community in Laconia; Meredith Bay Colony Club in Meredith and Franklin Regional Hospital in Franklin.
Her original photo notecards are blank inside and packaged with an envelope in a clear cellophane sleeve. They are available at: The Belknap Mill Gift Shop in Laconia; Bonita D. Story Antiques & Estate Jewelry in Meredith; Gibson's Bookstore in Concord; the Sanbornton Public Library in Sanbornton; Lamb's Ear Yarns in Gilford; the Howling Coyote Gift Shop at the Squam Lakes Natural Science Center in Holderness; New England Porch Rockers in Laconia; and VynnArt Art Supply & Gallery in Meredith.
Her photos have been published in New Hampshire newspapers and on websites. She is the author of two photo essay books, The Earth Goes to Sleep and The Earth Wakes Up. Her photos are available in various sizes, matted & mounted; framed or unframed. Inquiries and commissions are always welcome.
The theme of her exhibit at the Belknap Mill is "Discovery," and Bonafide explains her technique, "I take photographs of nature, mostly, and sometimes of people. I choose a subject carefully, thinking about how light is illuminating it, how I will 'frame' it, planning the angle of the photograph, and shooting the photograph at the right moment. I do not enhance my images with photo manipulation software. I want my nature photos to be completely natural."
Last Updated on Friday, 30 May 2014 09:24
Hits: 231
Bank of New Hampshire Returns as $10,000 Title Sponsor of the 2014 LRGHealthcare Golf Classic
LACONIA — For the sixth year Bank of New Hampshire has signed on as the $10,000 Title Sponsor for the LRGHealthcare Golf Classic.
The August 11 tournament will take place at Laconia Country Club. Players will participate in a scramble format, choosing to golf in either the morning or afternoon round (shotgun starts at 8:30 a.m. and 2 p.m.). Each flight will be followed by a meal, gifts, and prizes for the participants.
Over the years this tournament has raised more than $912,000 to support the LRGHealthcare HealthLink Program, an information and referral service as well as an access program for those who are uninsured or underinsured in the Lakes and Three Rivers regions. The HealthLink Program now features a convenient voucher program. Every $100 raised through the Golf Classic connects a local patient in need with a medical provider.
"Bank of New Hampshire is proud to continue to sponsor the LRGHealthcare Golf Classic and the HealthLink program," states Mark Primeau, President & CEO for Bank of New Hampshire. "As partners in Lakes Region, together we strive to make our community stronger by providing important programs for the underinsured or uninsured."
"As we celebrate the 20th Anniversary of HealthLink we are reminded of the many local families who are able to receive medical services during a time of need," adds LRGHealthcare SVP of Administrative and Facilities Services Suzanne Stiles. "Deepest thanks to the hundreds of sponsors, supporters, and golfers who come out for a great day, for a very important cause."
Several sponsors have already joined Bank of New Hampshire in supporting this event, including GOLD SPONSOR DiGiorgio Associates Inc./Monitor Builders Inc.; SILVER SPONSORS Brennan & Pike and Cross Insurance; BRONZE SPONSORS Giguere Electric, Inc., Landmark Benefits, Inc., Meredith Village Savings Bank, and MetroCast Business Services; CART SPONSORS LRGHealthcare Board of Trustees and Franklin Savings Bank; and CORPORATE SPONSORS Golden View Health Care Center, Gragil Associates, Inc., Humana MarketPOINT, Inc., Jackson Lewis LLP, Northern Peabody LLC, and Stanley Elevator Company, Inc. The Irwin Automotive Group is proud to be a Hole-in-One sponsor of the LRGHealthcare Golf Classic.
Foursome spots and sponsorship opportunities are still available. For more information contact the Office of Philanthropy at LRGHealthcare, 527-7063 or visit our website: www.lrgh.org.
Last Updated on Friday, 30 May 2014 09:03
Hits: 174
Children's Auction Giving Guidelines described at June 17 meeting
LACONIA — Following an amazing 2013 WLNH Children's Auction which raised $510,801 to benefit local children and families, the Auction's Distribution Committee is holding a public meeting to outline its giving process and priorities for the 2014 auction on Tuesday, June 17 at 9 a.m. in the Taylor Communities Woodside Building, Elm room.
All current and formerly funded organizations, as well as 501 C-3 organizations which provide services to children across the WLNH Children's Auction service area (broadly defined as Lakes Region out to Bristol, up to Campton, over to Wolfeboro and across to the Franklin area), are welcomed to attend.
Many of the thousands of individuals who donate to the Auction each year are unaware of the process by which their donation is distributed to assist children and families. The distribution of their donation is separated into distinct categories (A, B, C +D). Category A is for immediate needs such as holiday toys, coats, boots, food and items that are essential for those in immediate need. The Salvation Army is an example of a Category A organization.
Category B is for those community services which provide support that ultimately will prevent people from requiring the types of immediate needs outlined in Category A. "B" services would teach people the skills necessary to be independent of social services over time, such as Lakes Region Community Services.
Category C funds are utilized for organizations' capital needs such as Lakes Region's Boys and Girls Club recent transition to the former Saint James Episcopal Church building in Laconia. Category D funds are for recreational activities for children such as the Circle Program.
The important thing for community members to understand isn't the specific categories, but that the WLNH Children's Auction invests their donations across a wide continuum of community services. The application process demands that organizations have local governance and can quantifiably demonstrate that they have produced the results your donation has made possible. "The process by which the WLNH Children's Auction distributes funds really is extensive," sited Distribution Co-Chair Christopher Boothby. "All Auction donations are strategically reinvested into our communities to insure that collectively, we get the best outcomes for our children and families in need".
A complete list of funded organizations, along with funding criteria and application information can be found at www.childrensauction.com. To RSVP, or for more information about the Distribution Committee's public meeting call 520-8185.
Last Updated on Friday, 30 May 2014 08:56
Hits: 102
More Articles...
- Willie J Laws Band at Tower Hill Tavern
- International Film Series – Life, Above All, Monday, June 2
- Globe Manufacturing honored for long-time sponsorship of annual 'Kick for Cancer' martial arts tournament
- Audubon Society plans program on birdwatching
- Gilmanton Old Home Planning Underway
- Plymouth Area High School Class of 1984 Plans 30th Reunion


text:
Snow on the Kamogawa - January 2, 2015
Xmas Lights in Botanical Gardens - December 24, 2014
Kitano Tenmangu - November 16, 2014
Autumn Leaves on the Kamogawa - November 13, 2014
Jidai Matsuri - October 22, 2014
City Hall Robots - October 20, 2014
Photography in Japan 1853-1912 - August 29, 2014
Biwako Wind - August 20, 2014
Summertime in Kyoto - July 21, 2014
Mountain Trail - May 5, 2014
Sakura Season
I went out to Ueno Park today to see the Sakura, which are at full bloom. As expected it was crowded with people enjoying the fine weather. There were many groups camped under the trees eating and drinking, with many more walking down the pathway taking photos.
I have a full set of photos I will put up tomorrow. I still haven't chosen which ones to display. Taking the photos is not the hard part. Choosing which ones get shown and which ones don't make the cut is the hardest. Need some editorial assistance maybe ^^. I have the Sakura shots down to 74 from the original 400, so will try and pick a final 35 for tomorrow to post.
It was my birthday today, so here is a birthday Sakura shot until I put the rest up tomorrow.


text:
Owego Native Killed In Her Pennsylvania Home
Authorities say a woman who grew up in Tioga County was killed in her home in Pennsylvania. Two people, including a teenage boy, have been charged in her death.
According to police in Lancaster, 32-year-old Nicole Mathewson did not show up for her job as an elementary school teacher on Monday morning
Man Charged With Homicide In Otsego County Death
Mygatt St. Murder Update
Police say two Binghamton men are in custody in connection with the death of a First Ward man whose body was found in his home shortly after a fire was extinguished yesterday morning.
Investigators say 21 year old Julian Talamantez IV and 25 year old Nigel Saunders are charged with murder and attempted murder


text:
Cavalcade of Whimsy
Dec. 9
Past Cavalcades
- 2008
Season | Sept.
1, Part 1 |
Sept. 1
- Part 2
- Week
1 (The Bradford Shoulder) |
Week 2
(Time To Boot the Big East?)
- Week 3 (The Ten New Stars)
- Week 4 (ESPN's responsibility)
- Week 5 (The incomparable Bobby
- Week 6 (The 10 big college
football arguments)
- Week 7 .. Part 1
| Part 2 - The Ten Best Players
In College Football ... so far -
Week 8
... Part 1 | Part 2 - You're an idiot if ...
Week 9
... Part 1 |
Part 2 - What if players
couldn't leave early for the NFL?
- Week
10 .. Part 1 | Part 2 -
Every conference race broken down
Week 11.. Part 1
| Part 2 - The 10 unsung
things you need to know -
Week 12.. Part 1
| Part 2 - Breaking Down The Award
Week 13
- The Notre Dame Circus | Part 2 Ten things to be grouchy
Pete Fiutak
- Part 2 - Ten things to be grouchy
Sorry if this column sucks, it's not my fault … I was too busy looking for my pants, which were coached off me by Nick Saban, and forgot to drink a glass of water.
"Look at me. Do I look like a guy who panics? Where did you go to medical school? I had a heart attack, you quack bastard."
... Urban Meyer was hospitalized following the loss in the SEC Championship game complaining of chest pains, but he was treated for dehydration. If only there was some sort of panther whiz-tasting, American kid-fattening, Tiger Woods-bailing, sugared-sports drink that existed that was supposed to replenish fluids. Urban, you're the head coach of the University of Florida Gators, as in Gatorade, as in you should be contractually obligated to have a cup of that garbage in your hands at all times, as in it was probably what was in the IV that zipped you back to normal. Didn't you see the commercials with the weird scientists who brilliantly came to the conclusion that football players in the heat and humidity of the Deep South needed to drink liquids?
"Ken, Lonny, I'd like you to meet ... Mohammet ... Jugdish, Sidney and Clayton. Grab a seat and make yourselves at home. Don't be shy about helping yourselves to punch and cookies." … Ladies and gentlemen, your 2010 Fiesta Bowl.
Oh, come on, BCS. Really? You're sticking TCU and Boise State at the kids table? It might be the best of the BCS bowls, and it'll be truly entertaining, but it does nothing to help the sport of college football move forward. Florida vs. Cincinnati is nice, but our lives would all be better and far more fulfilled with one easy switch: Florida vs. Boise State in the Sugar, and TCU vs. Cincinnati in the Fiesta. That way, the Horned Frog – Bearcat game would be for the No. 2 spot in the final rankings, Boise State would get a fair and honest shot at the biggest of the big names, and the Orange Bowl could've still had the Iowa fan base against Georgia Tech. Instead, we'll get nothing more than a slew of interesting exercises.
And wait for Congress to try and get a bill passed in time to give you an honest shot ... You're absolutely right, Bearcats, Horned Frogs, and Broncos, this does suck. Now go rock in the bowl games. Cincinnati, blast away Florida like Utah did against Alabama last year and we'll all take up your cause and you'll get the respect the Utes received. The winner in the Fiesta Bowl needs to do so in dominant fashion and not with some sort of Poinsettia Bowl-like 17-16 victory. Do that and prove that you should've been in Pasadena.
FBI man 1: Tell you what, Mr. Simpson, from now on your name is Homer Thompson, at Terror Lake. Let's just practice a bit, hmmmm? So when I say hello Mr. Thompson, you say hi.
Homer: Check!
FBI man 1: Hello, Mr. Thompson.
[Homer stares blankly]
FBI man 1: [pause]
FBI man 1: Now, remember, your name is Homer Thompson.
Homer: I gotcha!
FBI man 1: Hello, Mr. Thompson.
[again Homer stares blankly]
FBI man 1: [FBI men stare at each other]
[hours pass by]
FBI man 1: [frustrated] Argh... Now when I say "Hello Mr. Thompson" and press down on your foot, you smile and nod.
Homer: No problem.
[stepping hard on Homer's foot]
FBI man 1: Hello, Mr. Thompson.
[Homer stares blankly again for a few seconds]
Homer: [whispering to the FBI man next to him] I think he's talking to you. ... Stop it before you start. Don't even bring it up. There is no playoff, we're not going to get a playoff, and we won't be able to cue the wayback machine to turn back the clock in ten years to see if TCU, Cincinnati, or Boise State really did belong in the national title, so don't waste your time and energy. Instead, let's focus on the land of the real and possible and work on the current system, most importantly, the voting.
I'm fortunate enough to be on the inside of voting for many of the major awards and I'm seeing more and more how the process of these things are getting done. Rolando McClain is on CBS every week and the announcers praise him for being smart, so he gets the Butkus, while more deserving players go by the wayside because they don't get the pub. Some guy named Mike Iupati is a finalist for the Outland because Mel Kiper has him on his big board (ahh, ahhh, ahhhhh, ahhhhhhh-choooBlesto). And coaches vote in the top 25 based on team name, record, and highlights. This is a sport whose champion is based 2/3rds on judges and opinions, and they're misinformed, lazy, and wrong. I'd have less of a problem with Alabama vs. Texas in my national championship if I knew that more than five people voting in the polls could name the starting quarterbacks for all ten BCS teams.
"Hey man! It's really weird! Strange things keep happening. Like plates are disappearing and the tables keep, well, shrinking. Looks like there's a poltergoost in the house...." ... Ahhhhhh!!! Ahhhhh!!! The ghost of Walter Cronkite is doing promotions for the University of Texas!!! Phew, glad that's over. Ah, an ad for satellite radio. Ahhhhhh!!! Thin Elvis. Ahhhhhh!!!
If you thought 45-35 was bad ... They got the call right, and that's all that matters. It was one of the dumbest brain cramps in the history of college football, and because Colt McCoy lucked out and there was one second to play shouldn't excuse just how jaw-droppingily, mind-numbingly brainless Mack Brown and Texas were at the very end of the Big 12 Championship. They caught a huge, HUGE break that would've been the all-timer of all-timer choke jobs by a coaching staff had time run out. There's no conspiracy, and while Nebraska might be grouchy that it didn't work out, there really was one second still on the clock. For those of you who believe that Big 12 and the officials would've only put one second back on the clock for Texas and not Nebraska, because they wanted the Longhorns in the national title, remember, the conference would've made more money with a Husker win because then two teams would be in the BCS. If you're still mad at how things turned out, think of it this way; it would've been far, far worse controversy-wise had the officials said that time ran out, Nebraska got the win, and after the fact replay showed that there should've been one-second left on the clock. After what happened in 2008, Longhorn nation would've gone nuclear had Texas lost because of an official's error.
Ndamukong, Ndamukong, bo-Bdamukong, Banana-fana foKong, Fee-fi-mo-Kong, Ndamukong ... … It would be interesting to see how many Heisman voters put Ndamakong Suh, Ndamukong Sue, Sue Ndamukong, DonkeyKong Suh, or That Guy Who Kept Sitting On Colt McCoy's Head on their ballots.
There's no truth to the rumor that ... The janitors around the Alabama practice facilities have had to work overtime mopping up all of Terrence Cody's drool after he watched games tapes of the Big 12 Championship.
"No, Mr. Lieberstein -- your decision was based, not on consideration, but on FEAR!!! Fear of carpets STAINED!!! Of deliverymen CLAWED!!! Of kitty litter boxes tipped over!! Of hairballs coughed up!! We have seen this fear before: in Cambodia, under Pol Pot. In Russia, under Stalin. In Massachusetts, under Mitt Romney. It is the FEAR, sir, and the TYRANNY of with which we DARE no longer PUT!! I pray thee, sir, let us have done with it!!" ... With each passing word NBC Football Night In America analyst, Tony Dungy, is becoming more than just a mellonhead who's being exposed more and more each week; he's becoming dangerous.
Before the Minnesota-Arizona game on Sunday night, NBC aired a shoddy piece on the lack of minority head coaches in college football led by Dungy, who hinted that colleges and universities are racist because there are so few African-American head coaches at the FBS level. Dungy's fatal-flaw as a commentator is that he's trying to have it both ways. He tries to have opinions, which is what he's being paid by NBC to do, but he always stops short of true criticism because, like all coaches who go to the booth with a plan to someday get back on the sidelines, he doesn't want to burn any bridges. That's fine when it comes to the nuts-and-bolts of analyzing football, even though it makes him a bad studio presence, but it's unfair and incredibly irresponsible to do that when it comes to a topic as hot-button and inflammatory as racism.
I have no problem if Dungy, Charles Barkley, or anyone wants to out a college or university that they believe made a decision on a college football head coach based on skin color, but only if they go the extra step and say, "(insert school here and school president here) are racist."
Tony, if you believe a certain school that didn't interview Mike Tomlin did so only because Tomlin is an African-American, then call … it … out. Name names. Solve the problem. Have a solution. Don't just float the concept that college football is "institutionalized racism" when it comes to hiring practices, and then go to a commercial and move on to a piece about Brett Favre. And worse, don't imply that schools that employ a white head coach are inherently racist because they didn't hire an African-American.
To channel my inner Keith Olbermann, NBC, how dare you. How dare you have Bob Costas, who has never uttered a word he wasn't smugly proud of, do some voiced-over montage and show Danny Hope, Dabo Swinney, and Bill Snyder to suggest that Purdue, Clemson, and Kansas State, respectively, were
to blame for the lack of minorities in head coaching
jobs. Again, if you really believe that those schools were racist in their hiring practices, then prove it, say it, and don't suggest it. And Dungy, how dare you not apologize to Kansas State. Now.
Kansas State was the only school that Dungy mentioned by name as he told an anecdote about former defensive coordinator, Raheem Morris, the current Tampa Bay head coach, leaving for the pros because he didn't think he could get a head coaching job in college. First of all, what?! Second, report the whole story. Dungy
failed to point out that Kansas State sued Morris
for leaving early to take an assistant coaching job
at Tampa Bay; Kansas State wanted Morris to stay.
And third, KANSAS STATE HIRED RON PRINCE. Was Prince
fired because he's an African-American? No, he was
fired because he was bad at coaching football, but
in the world of this NBC piece, Kansas State is now
part of the problem because Bill Snyder, only a
legend at the school and the architect of one of the
greatest turnarounds in college football history,
wanted to come back to try to revive the program.
Now, the average NFL fan who watched this piece, and
has no idea who Prince is, has no choice to put a
mental checkmark next to Kansas State football.
Of course the lack of minority head coaches in college football is a disastrous embarrassment. No one is denying that and everyone with a brain would like this to be different. So what, besides a tougher form of the Rooney Rule, which is already in place, do you want to do about it? I'm not going to pretend to have an answer, but if a major pregame show is going to do a piece like this and if it's going to let Dungy do a half-assed commentary complete with potshots (along with a criticism of the "Pac 12"), then it had better have a stronger idea of how to fix the problem and who's to blame. Otherwise, what Dungy did made it sound like colleges should hire coaches based on the color of their skin.
What's most interesting about this is the timing, considering there wasn't one minority being rumored for the Notre Dame job. Did you see one shot of Irish football in the montage of white head coaches? Of course not, and take a wild guess why. It's not like there isn't a controversy around the program considering Charlie Weis was given another year that Ty Willingham wasn't. This was a bad enough piece to begin with, and if Dungy wanted to do this now as a shot against the Irish, and wasn't man enough to mention the words Notre and Dame because of the NBC deal, then this takes on a whole other level of shame and gutlessness.
And I'm still pushing for GameDay to come broadcast from my breakfast nook, but it snowed out and now there's no parking. They'd have to park around the block, they'd track salt in my house, and I'd have to find spots for their coats. It'd be a mess. … It's Week Seven of my open lobbying of the ESPN College Football Final show guys to give me a helmet sticker and the signed T-shirt, suitable for framing. Why do I deserve one this week? I took down my life-sized promotional poster of C.J. Spiller and I need something new for my wall.
- Part 2 - Ten things to be grouchy


text:
Beef Tostada Cups
7 Feb 2011
|Vegetable oil
|2 Cup (32 tbs) (For Deep Frying)
|Corn tortillas
|Beef filling
|1 Cup (16 tbs)
|Chili powder
|2 Teaspoon
|Ground cumin
|1 Teaspoon
|Lime juice
|2 Fluid Ounce (60 Milliliter)
|Rump steak
|1 Pound, trimmed of visible fat
|Red onions
|2 , sliced
|1⁄2 Bunch (50 gm)
1. Heat oil in a saucepan until a cube of bread dropped in browns in 50 seconds. Deep-fry tortillas, one at a time pressed between two metal ladles, for 1 minute or until crisp and golden. Drain on absorbent kitchen paper.
2. To make filling, place chilli powder, cumin and lime juice in a glass or ceramic dish and mix to combine. Add steak, turn to coat and marinate for 5 minutes. Drain steak and cook on a preheated barbecue or under a grill for 2-3 minutes each side or until cooked to your liking. Rest steak for 2 minutes, then cut into strips and place in a bowl. Add onions and coriander (cilantro) leaves and toss to combine.
3. To serve, divide filling between tostada cups and serve immediately.
Recipe Summary
Difficulty Level:Medium
Course:Main Dish
Method:Deep Fried
Preparation Time:30 Minutes
Cook Time:25 Minutes
Ready In:55 Minutes
Rate It
0 Comments
Beef Tostada Cups Recipe


text:
'Pablo' slow-crawls towards the west-northwest
Four areas remained under storm signals Wednesday night as Typhoon Pablo (Bopha) maintained its strength and moved west-northwest slowly, the Philippine Atmospheric, Geophysical and Astronomical Services Administration forecasters said.
'Pablo' weakens as it passes through Palawan. A DOST-PAGASA satellite image as of 8:30 a.m. Wednesday shows the location of Typhoon Pablo (Bopha) at 110 km northeast of Puerto Princesa City, Palawan. 'Pablo' has further weakened as it continues to move toward northern Palawan with maximum sustained winds of 130 kph. GMA News/PAGASA-DOST
In its 11 p.m. advisory, PAGASA said the typhoon packed maximum sustained winds of 120 kilometers per hour near the center, with gustiness of up to 150 kph, and it was moving west-northwest at 7 kph.
The state weather service said Typhoon Pablo was estimated to be 180 kilometers northwest of Roxas, Northern Palawan as of 10 p.m. By Thursday evening, it is expected to be 330 kms west of Coron, Palawan. By Friday evening it is expected to be 570 kms west of Coron, Palawan and outside the Philippine Area of Responsibility.
Under Storm Signal No. 3 are Northern Palawan and the Calamian Group of Islands, while the rest of Palawan is under Signal No. 2. Under Signal No. 1 is Occidental Mindoro.
PAGASA said Typhoon Pablo may bring rainfall of 10 to 18 millimeters per hour (heavy to intense) within its 400-km diameter.
It warned residents in low-lying and mountainous areas under storm signals to be alert against possible flash floods and landslides.
Also, it warned those in coastal areas under public storm warning signals 2 and 3 to be alert for big waves or storm surges.
PAGASA reminded fishing boats and other sea vessels not to venture out into the seaboards of Luzon and Western Visayas. — DVM, GMA News
Go to comments
We welcome healthy discussions and friendly debate! Please click Flag to alert us of a comment that may be abusive or threatening. Read our full comment policy here.Comments Powered by Disqus
Top Stories


text:
Auction to benefit Leukemia and Lymphoma Society
Jenna Heim, 20, a Simi Valley resident and childhood cancer survivor, will host a silent auction Thursday to benefit the Leukemia and Lymphoma Society.
The auction will be combined with bowling at the Brunswick Bowl, 5255 Cochran St. in Simi Valley. The auction will be from 7:30 to 8:30 p.m.
The bowling fee is $10 for two hours of bowling. Bowling is optional.
More than 50 items will be auctioned. No registration is necessary. For more information, call 304-6884.
Subscribe to the Ventura County Star
Ready to subscribe to the Ventura County Star? Choose between a Premium or Digital subscription below.
Need Help? Call us at 1-877-710-6182.
Monday-Friday: 6am-3pm / Saturday: 6:30am-10:30am / Sunday: 7am-11am


text:
Jonas Brothers Confirm New Upcoming Single 'Pom Poms'!
The Jonas Brothers revealed to "On Air with Ryan Seacrest" today that their next upcoming single,"Pom Poms" will be available this Spring. The trio also confrimed that they shot a video for the new track over the weekend in New Orleans. The video will feature cheerleading squads from the Saints and Hornets as well as the marching band from Southern University.
The Jonas Brothers formed in 2005, and gained popularity from their show on the Disney Channel. The three brothers, Kevin, Joe and Nick hail from New Jersey. In 2008 they starred in the Disney Channel Original Movies Camp Rock and its sequel, Camp Rock 2: The Final Jam.
The band has released four albums: It's About Time, Jonas Brothers, A Little Bit Longer, and Lines, Vines and Trying Times, with an upcoming fifth studio album due for release in 2013.
In 2008, the group was nominated for the Best New Artist award at the 51st Grammy Awards and won the award for Breakthrough Artist at the American Music Awards. As of May 2009, before the release of Lines, Vines and Trying Times, they have sold over eight million albums worldwide.
|Related Links
|Hilton First to Stream Live Nick Jonas Concert on Twitter's Periscope
April 22, 2015
|Nick Jonas Takes the Stage for Hilton PLAY Concert This Month
April 01, 2015
|OLIVIA SOMERLYN to Perform at Annual Oscars Pre-Awards Dinner Party
February 28, 2014
About Author
- CNBC to Air THE MAKING OF DIG, the USA Network Event Series, 3/1
- NBC to Air One-Hour Season Finale of CHRISTINA MILIAN TURNED UP, 3/1
- NBC Universo to Present ROMEO SANTOS DESDE VINA Concert Exclusive, 3/1
- Kelly Clarkson to Visit CBS SUNDAY MORNING, 3/1
- VIDEO: Clark Gregg Teases New AGENTS OF S.H.I.E.L.D. Season Using Emojis
- Dakota Johnson to Host SNL Tonight; Alabama Shakes to Perform
- NBC Sports to Air Coverage of U.S. GRAND PRIX FROM PARK CITY
- Discovery Family to Premiere New Episodes of TRANSFORMERS RESCUE BOTS, Today
- Telemundo to Present FUTBOL ESTELAR: LEON VS SANTOS, Today
- Telemundo to Give Viewers Sneak Peek at Upcoming Programming on LO NUEVO, Today


text:
Originally written on Bush League Chronicle | Last updated 2/16/13
The reigning American League Rookie of the Year raised a few eyebrows this week after showing up to spring training camp with a little extra bagged. No, it wasn't of the luggage variety, either.Los Angeles Angels outfielder Mike Trout reportedly tipped the scales at 240 pounds this week after being weighed in around 210 last spring. The initial reports claim that the extra weight isn't just muscle, either.Angeles beat writer Mike DiGiovanna wrote that the 21-year-old has a body more like an NFL fullback now rather than the running back body he sported one year ago. This has some fantasy baseball nerds concerned on how the added bulk may affect Trout's production, especially on the base paths and on defense."You know, my weight fluctuates," Trout said during a pres. "During the course of Spring Training, I'll lose probably five to 10 pounds. So, where I need to be to start the year, I felt like coming in heavier and then getting down my weight to start the year. I know where I need to be."The New Jersey native took the major league landscape by storm in '12 while batting .326 with 30 homers, 83 RBI, and a whopping 49 stolen bases. His stellar rookie campaign earned him an All-Star nod, a Silver Slugger Award, and a runner-up finish in the MVP voting. But some are worried that the freak athlete may be in for the dreaded "sophomore slump" in his second full season in the bigs. The extra weight he reportedly packed on isn't going to lessen their worries, either.Via Sporting News
Comments are closed.
What do you think?To leave a comment, you can:
MLB News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
Follow us on Twitter
|Best of Yardbarker
|NFL News
|MLB News
Today's Best Stuff
For Bloggers
Join the Yardbarker Network for more promotion, traffic, and money.
Company Info
What is Yardbarker?
Yardbarker is the largest network of sports blogs and pro athlete blogs on the web. This site is the hub of the Yardbarker Network, where our editors and algorithms curate the best sports content from our network and beyond.
|© 2015 Yardbarker, Inc. All rights reserved. Use of this website (including any and all parts and components) constitutes your acceptance of these Terms of Use and Privacy Policy. (What's New?)


text:
2013-02-12 - On March 30th Avantasia will release their new album "The Mystery Of Time". Several journalists have already made comments that the new epic might mark the best Avantasia album ever, featuring ten tracks and guest stars such as Biff Byford (Saxon), Michael Kiske (Unisonic, ex-Helloween), Joe Lynn Turner (ex-Rainbow, ex-Deep Purple), Eric Martin (Mr. Big), Ronnie Atkins (Pretty Maids), Bruce Kulick (ex-Kiss, ex-Meat Loaf), Arjen Lucassen (Ayreon), Russell Gilbrook (Uriah Heep) and more…
Now another vocalist can be confirmed for the album: Bob Catley, legendary frontman of British Epic Rock storytellers Magnum. And Bob will not only be featured on the album, besides Michael Kiske, Amanda Somerville and Eric Martin, Bob has also been confirmed to join Avantasia on their forthcoming world tour.
Watch the videomessage of Bob Catley here:
For their own April indoor shows (not festivals), Avantasia have been confirmed to play 3-hours special shows, not only celebrating the release of their forthcoming album, but also embracing all eras of the bands history.
|Groupes similaires
NUCLEAR BLAST – Wacken Open Air, full ...
2014-08-06 13:00 - Wacken Open Air just celebrated its 25th anniversary last week and is looking forward to the 26th edition in 2015. For anyone who missed the annual festival madness in the ... Détails
2014-07-29 11:30 - 29.07.2014 11:30 - La longue attente touchera à sa fin cette semaine avec l'ouverture de la 25ème édition du festival de Wacken sur les terres du nord de l'Allemagne. Pour ... Détails
2014-06-27 00:00 - Two days prior to the beginning of the 25th edition of Wacken Open Air AVANTASIA are going to play a special "Family & Friends Show" at Eiderland-Halle, Pahlen. A bus ... Détails
NUCLEAR BLAST – Bands honored at METAL ...
2013-09-17 01:00 - At this year's edition of the annual METAL HAMMER AWARDS, that took place this past Friday, September 13 in Berlin four Nuclear Blast Bands succeeded in the following ... Détails
BLOODSTOCK FESTIVAL to be live streamed vi...
2013-08-08 00:00 - If you can't get along to the award-winning BLOODSTOCK FESTIVAL this weekend for whatever reason, don't fret, because you can catch many of the main stage band sets on the ... Détails
METAL HAMMER AWARDS – vote for your favour...
2013-04-18 03:00 - This year, Metal Hammer Germany will award their annual Metal Hammer Awards for the fifth time on Friday, September 13, at the "Kesselhaus" in Berlin, Germany, with live pe... Détails
AVANTASIA - Enter the united world charts!
2013-04-16 01:00 - Just after we received the information that the new album THE MYSTERY OF TIME has also entered the Swiss album Top 10 charts at #5 we can proudly announce that it has also ... Détails
AVANTASIA: Hit the german charts at #2!
2013-04-09 02:00 - While the band are preparing to hit the road and bring the biggest show in the band's history to the stages around the globe (featured guests will be Michael Kiske, Bob ... Détails
AVANTASIA - full album stream available!
2013-04-02 17:50 - Finally the new AVANTASIA masterpiece "The Mystery Of Time" has hit the stores. Many journalists have already stated, that the album might be the most enchanting and ... Détails
AVANTASIA: New Album out on Friday!
2013-03-28 06:00 - Finally the time has come and the new AVANTASIA masterpiece "The Mystery Of Time" will hit the stores. Many journalists have already stated, that the album might be the ... Détails


text:
Formula 1-Monaco Grand Prix Lineup
Updated: May 25, 2013, 11:15 AM ETAssociated Press
After Saturday qualifying; race Sunday
At Circuit de Monaco
Lap length: 2.075 miles
Third Session
1. Nico Rosberg, Germany, Mercedes, 1 minute, 13.876 seconds.
2. Lewis Hamilton, England, Mercedes, 1:13.967.
3. Sebastian Vettel, Germany, Red Bull, 1:13.980.
4. Mark Webber, Australia, Red Bull, 1:14.181.
5. Kimi Raikkonen, Finland, Lotus, 1:14.822.
6. Fernando Alonso, Spain, Ferrari, 1:14.824.
7. Sergio Perez, Mexico, McLaren, ...
Read full story
You must be signed in to post a comment
You are fully responsible for the content you post. Content that includes profanity, personal attacks or antisocial behavior (such as "spamming" or "trolling"), or other inappropriate content or material will be removed. We reserve the right to block any user who violates our terms of use, including removing all content posted by that user.


text:
Force Elektro is the Ultimate Frisbee club of Delft. We train a few times per week and also play in the national competition as well as various tournaments.
Oh, have you seen our Urban Ultimate video already? The same sport, but in a slightly different scenery.
TU Delft's Sport & Culture is looking for a new frisbee trainer. Do you have experience as a trainer and in Ultimate look here.
- One of the Force Elektro teams at our own tournament Rising High -


text:
Are you Alain Laplante?Claim your profile
Publications (7)29.24 Total impact
- SourceAvailable from: Borhane Annabi
Article: Modulation of matrix gelatinases and metalloproteinase-activating process in acute kidney rejection[Show abstract] [Hide abstract]
ABSTRACT: Changes in matrix metalloproteinase (MMP) activities would contribute to the accumulation of extracellular matrix during acute kidney allograft rejection. MMP-2 and MMP-9 and other gelatinolytic activities were examined in the rejected graft and the urine of a rat model of acute kidney rejection (orthotopic allotransplantation from a Buffalo donor to a Wistar-Furth recipient) by either zymography or fluorescence assay. MMP-2, membrane type 1 (MT1)-MMP, and tissue inhibitor of metalloproteinase (TIMP)-2 were also examined by immunodetection. The proMMP-2 activity and protein level increased in the graft during rejection when compared with normal Buffalo kidney, whereas activated MMP-2 decreased. TIMP-2 protein levels were markedly decreased and MT1-MMP proteolytic fragments (44-40 kDa) were undetectable. This suggests an altered MT1-MMP-dependent processing of proMMP-2 into active MMP-2 due to a diminished TIMP-2 level in acute kidney rejection. In the urine the overall gelatinolytic activity decreased considerably, although activity associated with an as yet unidentified 78-kDa protein appeared 6 days after transplantation.Transplant International 05/2003; 16(4):262-9. DOI:10.1007/s00147-002-0540-8 · 3.16 Impact Factor
Article: Interaction of immunosuppressive agents rapamycin and its analogue SDZ-RAD with endothelial P-GPTransplantation Proceedings 01/2003; 34(8):3393-5. DOI:10.1016/S0041-1345(02)03658-8 · 0.95 Impact Factor
Article: Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier.[Show abstract] [Hide abstract]
ABSTRACT: 1. The blood-brain barrier (BBB) contributes to brain homeostastis and fulfills a protective function by controlling the access of solutes and toxic substances to the central nervous system (CNS). The efflux transporter P-glycoprotein (P-gp) is a key element of the molecular machinery that confers special permeability properties to the BBB. 2. P-gp, which was initially recognized for its ability to expel anticancer drugs from multidrug-resistant cancer cells, is strongly expressed in brain capillaries. Its expression in the BBB limits the accumulation of many hydrophobic molecules and potentially toxic substances in the brain. 3. The purpose of this review is to summarize the current state of knowledge about the expression of P-gp, its cellular localization as well as its possible functions in the BBB.Vascular Pharmacology 07/2002; 38(6):339-48. DOI:10.1016/S1537-1891(02)00201-X · 4.62 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Malignant brain tumors and brain metastases present a formidable clinical challenge against which no significant advances have been made over the last decade. Multidrug resistance (MDR) is one of the main factors in the failure of chemotherapy against central nervous system tumors. The MDR1 gene encoding P-glycoprotein (P-gp), a drug efflux pump which plays a significant role in modulating MDR in a wide variety of human cancers, is highly expressed in the blood-brain barrier (BBB). The BBB controls central nervous system exposure to many endogenous and exogenous substances. The exact molecular mechanisms by which the BBB is involved in the resistance of brain tumors to chemotherapy remain to be identified. The purpose of this review is to summarize reports demonstrating that P-gp, one of the most phenotypically important markers of the BBB, is present in primary brain tumors and thus plays a crucial role in their clinical resistance to chemotherapy.Cancer and metastasis reviews 02/2001; 20(1-2):13-25. DOI:10.1023/A:1013104423154 · 6.45 Impact Factor
Article: Association of cyclophilin A with renal brush border membranes: Redistribution by cyclosporine A[Show abstract] [Hide abstract]
ABSTRACT: Administration of the immunosuppressive agent cyclosporine A (CsA) is associated with nephrotoxicity. The main target for CsA, cyclophilin A (CypA), was found in high levels in epithelial cells of renal proximal tubules. In the present study, CypA was immunodetected and characterized following CsA treatment in subcellular fractions of renal cortex. The renal content and distribution of CypA was evaluated in untreated rats and in rats treated with a subcutaneous injection of CsA (10 mg. kg-1. day-1) for 10 days. In untreated rats, membrane-bound CypA represents 0.25% of total brush border membrane (BBM) proteins, similar to the proportion found in the soluble fraction. High ionic strength treatment was unable to extract CypA from BBMs, whereas alkaline treatment (Na2CO2, pH 11) and detergent 3 - [(3 - cholamidopropyl) - dimethyl - ammonio] - 1 - propanesulfate (CHAPS) released it from BBMs. These results indicate that CypA is associated with renal BBMs, and that hydrophobic interactions are involved in this association. The CypA distribution was strongly modified in both BBMs and the soluble fraction after CsA treatment, but its affinity for CsA estimated by photoaffinity labeling was unaffected. The CypA expression level decreased by 45% in BBMs, while it increased by 33% in the soluble fraction, compared with control rats. CypA remained associated with the membranes following in vitro incubation of renal BBMs with CsA. However, incubation of CypA with one of its substrates released CypA from renal BBMs. These experiments suggest that renal BBMs contain a significant amount of CypA and chronic exposure to CsA, and acute exposure to one of CypA substrates may modify its subcellular distribution.Kidney International 05/2000; 57(4):1590-8. DOI:10.1046/j.1523-1755.2000.00003.x · 8.52 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The interaction between P-glycoprotein (P-gp) from membranes isolated from multidrug-resistant Chinese hamster ovary cells and cyclosporin A (CsA) analogues and its metabolites was characterized. Screening of these latter as chemosensitizers was performed using three different assays: (i) vinblastine uptake, (ii) photoaffinity labeling by [125I]iodoaryl azidoprazosin, and (iii) P-gp ATPase activity. Oxidation of the hydroxyl group at position I of CsA (200-096), CsG (215-834), or CsD (PSC-833) increased their inhibition of P-gp. CsA analogues (208-032, 208-183) modified at position 11 retained their ability to inhibit P-gp while analogues modified at position 2 (CsC and CsD) lost their efficiency. The inhibitions induced by metabolites of CsA were also compared to those obtained with CsG metabolites. From all the molecules tested, PSC-833 and 280-446 peptolide were the strongest inhibitors. Our results indicate that modifications of CsA analogues at position 1 and 2 are critical for their interaction with P-gp and that CsA metabolites retain a portion of the inhibitory activity of the parent drug.Biochemistry and Cell Biology 02/1999; 77(1):47-58. DOI:10.1139/bcb-77-1-47 · 2.35 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The binding site of cyclosporin A to P-glycoprotein was characterized by using a multidrug-resistant Chinese hamster ovary cell line. P-glycoprotein photolabeled with diazirine-cyclosporin A analogue was purified by a two-step process involving continuous elution electrophoresis followed by wheat germ agglutinin-agarose precipitation. The cyclosporin A covalently bound to P-glycoprotein and to subsequent proteolytic fragments was detected by Western blot analysis using a monoclonal antibody against cyclosporin A. Proteolytic digestion of purified P-glycoprotein by V8 generated a major fragment of 15 kDa photolabeled by cyclosporin A, while proteolysis of P-glycoprotein photolabeled by [125I]-iodoaryl azidoprazosin generated a major fragment of 7 kDa. Limited proteolysis of cyclosporin A-photolabeled P-glycoprotein with trypsin indicated that the major binding site for cyclosporin A was in the C-terminal half of the protein. This cyclosporin A binding site was further characterized with chemical agents (N-chlorosuccinimide, cyanogen bromide, and 2-nitro-5-thiocyanobenzoate). These three chemical agents established a proteolytic profile of P-glycoprotein for fragments photolabeled with cyclosporin A and for fragments that contained the C494 and C219 epitopes. The smallest fragments generated by these chemical agents include the transmembrane domains (TMs) 10, 11, and 12 of P-glycoprotein. When the fragments generated by these chemical agents are aligned, the region that binds cyclosporin A is reduced to the 953-1007 residues. These combined results suggest that the major binding site of cyclosporin A occurs between the end of TM 11 and the end of TM 12.Biochemistry 01/1999; 37(51):18110-8. DOI:10.1021/bi981992c · 3.19 Impact Factor
Top Journals
CHU Sainte-JustineMontréal, Quebec, Canada
NovartisBâle, Basel-City, Switzerland