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Using the world's most powerful X-ray laser, scientists have exposed a possible Achilles' heel of the sleeping sickness parasite that threatens more than 60 million people in sub-Saharan Africa. The sophisticated analysis revealed the blueprint for a molecular plug that can selectively block a vital enzyme of the parasite Trypanosoma brucei. Plugging such a tailor-made molecule into the right place of the enzyme would render it inactive, thereby killing the parasite. The team led by DESY scientist Prof. Henry Chapman from the Center of Free-Electron Laser Science (CFEL), Prof. Christian Betzel from the University of Hamburg and Dr. Lars Redecke from the joint Junior Research Group "Structural Infection Biology using new Radiation Sources (SIAS)" of the Universities of Hamburg and Lübeck report their findings in the journal Science. "This is the first new biological structure solved with a free-electron laser," said Chapman.
The researchers had investigated tiny crystals of the parasite's enzyme cathepsin B with intense X-rays from the free-electron laser Linac Coherent Light Source (LCLS) at the US National Accelerator Laboratory SLAC in California. "The enzyme had emerged as a promising drug target in earlier trials", said Redecke, one of the first authors of the scientific paper. "The knockdown of this essential enzyme in the parasite did cure the infection in mice."
But the same enzyme is also part of the human - and in fact of all mammalian - biochemistry, and blocking it has severe consequences. With their analysis the scientists could now pinpoint distinctive structural differences between the human and the parasite's form of the enzyme. "This should in principle allow for designing a molecule that selectively blocks the parasite's enzyme while leaving the patient's intact", explained the other first author of the paper, Karol Nass, PhD student at the Hamburg School for Structure and Dynamics in Infection (SDI), funded by the Excellence Initiative of the German Federal State of Hamburg (LEXI), The researchers stress that while the finding raises hopes, a possible new drug is still a long way to go.
Sleeping sickness, or human African trypanosomiasis (HAT), is transmitted by the bite of the tsetse fly. The Trypanosoma parasites invade the central nervous system, and without treatment the infection is usually fatal. The disease occurs in 36 sub-Saharan countries and affects mostly poor populations living in remote rural areas. Thanks to intensified control measures the number of reported cases fell steeply in recent years, but there are still millions at risk. Current treatments of HAT rely on anti-parasitic drugs developed without knowledge of the biochemical pathways. They are not always as effective and as safe as desired, and the parasites are increasingly becoming resistant to these drugs. New drugs that selectively kill the parasite without affecting the patient's own organism would be of great use.
With cathepsin B the scientists applied a novel approach by investigating tiny crystals of the enzyme that were grown in insect cells in vivo. This way the enzyme was frozen in its natural configuration that includes a native inhibitor. Because cathepsin B works as a sort of molecular scissors cutting away at other proteins, it is produced by the cell in an inhibited form and only activated when needed. In the inhibited form a small peptide molecule is blocking the cutting edge of the molecular scissors. "With the peptide still in place we could peer below a previously impenetrable part of the cathepsin B structure ", explained Betzel. There, the analysis revealed significant differences between the peptide binding sites at the parasite's and the human form of cathepsin B. "This way, nature provided us with a blueprint of what an artificial inhibitor for the parasite's enzyme could look like." The next step would be to synthesise such a tailor-made plug and test it in the lab.
The molecular structure of the enzyme was solved to the atomic level by shooting bright X-ray flashes at the tiny cathepsin B crystals, which were only about a micron (a thousandth of a millimetre) in diameter and about ten microns long on average. Crystals scatter X-rays in a characteristic way that depends on their inner structure. From the resulting diffraction pattern the structure of the crystals can be calculated, in this case revealing the structure of the enzyme. Today, crystallography is a standard technique to analyse biomolecules. Usually, scientists use modified bacteria to produce biomolecules in large amounts and try to crystallise them into the largest possible sizes of high-quality crystals afterwards. The in vivo crystallisation pioneered at the labs of Betzel and Prof. Michael Duszenko at the University of Tübingen, who is also a member of the research team, employs living cells to produce crystals. In contrast to standard crystallisation experiments, only in vivo crystallisation yielded suitable crystals of cathepsin B in a natively inhibited form.
But the in vivo crystals are still so small that only X-ray lasers like LCLS are bright enough to produce sufficiently detailed diffraction images. The LCLS belongs to a novel class of scientific light sources called free-electron lasers that are based on powerful particle accelerators. In these machines, electrons are accelerated to high speeds, or energies, and are then forced on a tight slalom course. In every bend each electron emits a tiny flash, and all the flashes add up to an incredibly strong X-ray pulse with laser properties, that allows to resolve structures like the natively inhibited cathepsin B molecule.
To solve the cathepsin B structure the researchers had to record hundreds of thousands of diffraction images that were painstakingly stitched together afterwards. As each crystal is destroyed when hit by the powerful X-ray flash, the team fed a stream of crystals in a watery solution through a thin nozzle into the laser path. The X-ray laser fired away at 120 shots per second, where on average only every eleventh shot actually hit a crystal. This resulted in a total of 293,195 diffraction images recorded. These could only be processed with massive parallel computing, to first generate a three-dimensional map of the entire diffracting signals of the enzyme from which an image of its structure was calculated. The final result revealed the enzyme's structure with a resolution of 2.1 Ångström (one Ångström is a tenth of a nanometre or a ten-millionth of a millimetre). "Interestingly, this discovery comes exactly at the centenary of the publication of the famous X-ray diffraction equation by William Bragg in 1912," Chapman pointed out.
The team included members from DESY, the Universities of Hamburg, Lübeck, Tübingen, Uppsala and Gothenburg, the Arizona State University, SLAC, Lawrence Livermore National Laboratory, the Max Planck institute for medical research in Heidelberg and the Max Planck advanced study group at CFEL. CFEL is a joint venture of DESY, the Max Planck society and the University of Hamburg. DESY is the leading German accelerator centre and one of the leading worldwide.
Helmholtz Association of German Research Centres: http://www.helmholtz.de/en/index.html
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Evidence was weak that marijuana helps anxiety and sleep disorders
Ageing doesn't mean a steady descent into misery – evidence suggests that happiness is likely to increase as we head towards old age, but is it that simple?
The Ebola epidemic in Guinea that began early last year has set back the country's fight against malaria, say experts.
New diagnostics can find the DNA that drives a tumor, but evidence that they help patients is missing.
Scientists agree that children raised by same-sex couples are no worse off than children raised by parents of the opposite sex, according to a new study co-authored by a University of Oregon professor.
Children as young as 3 years old will step in to right the wrong if they see someone being mistreated, a study finds. But they aren't as keen as 5-year-olds to dole out punishment.
Millions suffer from SAD in summer as well as winter, and evidence hints that birth season plays a role in who develops the disorder
International panel says climate change is already affecting people's health, but there are steps we can take
A new federal study has answers
When Middle East respiratory syndrome erupted in South Korea, people started wearing masks everywhere, even at weddings. So how good are these masks at stopping MERS or even the flu?


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SOLD in the Houston Springs Subdivision in Perry GASOLD in Perry GAHelping sellers market their home and find the right buyer is what I love to do. Fortunately, this home in a 55+ community was exactly what the out-of-state buyer was looking for. The result is another home SOLD in the Houston Spr...
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I know many Rainers only use photos in their blog posts they take themselves. While I personally do not subscribe to that methodology, I know it is the only sure-fire way to make sure you are not improperly using someone else's material. For me, there are times when I need or want a photo to make...
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Homes for Sale in Georgian Walk Subdivision in Byron GAGeorgian Walk Subdivision InformationThe Georgian Walk Subdivision in Byron GA is an established community, found off White Road. With mature trees and landscaping as well as decent sized yards, this neighborhood could be the ideal location f...
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If you love fireworks, music, and old fashioned fun - come on over to the Madison and Lake Oconee area this weekend.July 3Summer in Madison would not be complete without this free celebration featuring live patriotic music by Georgia's longest operating community band, the Athens Classic City Ban...
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Lease Option vs Lease Purchase Buying a home through rent to own contracts has become more popular in recent years and there are two basic platforms that are most often used in these scenarios; a lease purchase or a lease option. While they are similar, there are some big differences that may af...
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This post originally appeared at MyMidtownMojo.com For those of you in love with the organic grocery that is all over Atlanta, you are going to have one gosh darn close to your Midtown Atlanta condo. But don't get out the reusable grocery bag just yet.On June 9th, plans for an "organic grocery st...
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Wed October 24, 2012
Several Alabama Cities Plan Veterans Day Events
Several Alabama cities are planning parades, memorial services and other events for Veterans Day weekend.
The state tourism agency says Birmingham will stage its 65th annual commemoration with a big parade downtown on Monday, Nov. 12. It is one of the largest Veterans Day observances in the country. Mobile, Montgomery and Huntsville will also have parades that day. Mobile will have a patriotic concert that night at the USS Alabama Battleship Park.
Fairhope, Foley and Tuscumbia have parades set for Saturday, Nov. 10. Alexander City has a commemoration scheduled for Sunday, Nov. 11 at Veterans Memorial Park.
Copyright 2012 The Associated Press.


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The Global FlyFisher - The Largest and Best Place to go for Online Fly Fishing and Fly Tying
GFF Blog
Wednesday August 9th 2006
Not quite
Not quite
|Published: Wednesday August 9th 2006 (9 years ago)
Updated: Wednesday August 9th 2006, 11:37AM
by Martin Joergensen
We haven't reached the heights of the US, but still...
Here in Denmark we have now had the 40th day with what is referred to as "bathing temperatures". That is when the ocean water averages above 19 deg. C or about 66 deg. F over 24 hours.


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Genomics Core
The Genomics Core at the Center for Genetic Medicine is a shared resource facility that provides genomic services to investigators at the Robert H. Lurie Comprehensive Cancer Center, the Feinberg School of Medicine, Northwestern University and external users. Our goal is to facilitate the utilization of the state-of-the-art technologies in genomics research by Northwestern faculty and researchers nationwide at a competitive price and in a timely fashion.
The Genomics Core Facility offers a multitude of genomic services, including a range of traditional sequencing and fragment analysis options using our ABI 3730 high-throughput sequencer, sequencing with the Ion Torrent System, analysis for gene expression, methylation and SNP studies using Affymetrix technology and the Illumina iScan system, and validation of methylation and SNP analyses using the Sequenom MassARRAY4 system.
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- qPCR Office Hours at the Genomics Core Facility
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""I've got a list of corporations that have gotten out of their airplanes [because of criticism from politicians]. It is the stupidest thing I've ever seen. When you look at the time and cost savings; it does not make sense not to fly [privately]. You can't let public perception interfere with your business decision to fly. It either is a good business decision or it isn't.""
Latin American Aviation Show Makes a Comeback
When organizers cancelled last year's Latin American Business Aviation Conference & Exhibition (LABACE) in São Paulo, Brazil, questions arose about the show's future. But the success of LABACE 2007, which ended a three-day run August 11, appeared to put those questions to rest. A record 6,041 attendees passed through the gate, according to Rui Thomaz de Aquino, president, Associaçao Brasileira de Aviaçao Geral, which now has responsibility for the show. LABACE also set records for numbers of exhibitors (71) and aircraft on display (35). And, Aquino noted, preliminary estimates are that aircraft manufacturer orders taken at the show exceeded $200 million, well over the forecast of about $150 million. To highlight the event, Brazilian manufacturer Embraer flew in its Phenom 100 for the VLJ's public debut.
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Andrea Walton, 18, one of youngest to serve as delegate to national political convention
PRINCETON, Ind. - When Princeton resident Andrea Walton flies to Charlotte, N.C., in a few weeks, she will do so as one of the youngest Americans to ever serve as a delegate to a national political convention.
Walton, 18, will be among more than 5,000 delegates and alternates from all 50 states, the District of Columbia and five U.S. territories who will converge on Charlotte's Time Warner Cable Arena convention hall Sept. 4-6. The Republican National Convention in Tampa Bay, Fla., Aug. 27-30 will draw more than 4,200 delegates and alternates.
Neither national party keeps records on teenage national convention
delegates, but both say it happens. Within the thousands of longtime party activists, donors, leaders and elected officials who typically get tapped to be delegates, there's always a handful who look like they should be home in bed.
Democratic Party rules specify that national convention delegates must be at least 18, but 17-year-old Minnesotan David Gilbert-Pederson was eligible to be chosen in 2008 because he turned 18 before Election Day.
This year, neither party has certified all its delegates, so neither has a full complement of names to release — but it is known that 19-year-old Anna Langthorn will be a Democratic alternate delegate from Oklahoma.
"I'm honored that I got chosen and really excited to go and meet new people and represent Gibson County," said Walton, who was recommended by area party leaders who wanted to promote capable newcomers and cultivate a deep bench of future leaders.
Walton, who plans to major in political science at American University in Washington, D.C., beginning in the fall, met Vice President Joe Biden last summer, while serving as a page in the U.S. House of Representatives.
Meeting President Barack Obama at this summer's convention, she said, would be "really cool."
Going to the convention as a credentialed delegate may look good on Walton's resume, but it won't be free.
Anthony Long, chairman of the 8th congressional district Democratic Party and a veteran of at least a half-dozen national conventions, says the frugal delegate can keep expenses in the hundreds rather than thousands of dollars with luck and diligence. It helps, Long said, to share a hotel room and other costs, book economy flights and take maximum advantage of free Indiana delegation meals and convention-wide nightly social hours.
"For a person to go and not share expenses with anybody, just go and have your own hotel room, probably you could get by $2,000 or less," Long said.
The Waltons have already plunked down $500 for Andrea's hotel room at the convention — a cost that was cut in half by agreeing to share rooms with a 26-year-old female convention page from Indianapolis.
Princeton resident Linda Walton, Andrea's mother, said the family will come up with the rest of the money. Linda Walton is a senior sourcing specialist at Duke Energy, and father David Walton is a stay-at-home dad. With Andrea's looming entry into American University, the couple will have two daughters in college.
Minnesota's Gilbert-Pederson raised the money he needed with the help of an ice cream social at his home with friends and family, but Linda Walton said the family has the matter in hand.
"We'll make sure it happens," she said.
Linda and David Walton are not political activists, Linda Walton said, and the couple were never in position to pull any strings for their daughter.
"Andrea has done this all on her own. We just told her to go for it. The worst they could do was say no," Linda Walton said.
Adding an element of comic relief to Andrea's preparations for the Democratic convention is the fact that her father leans Republican and her paternal grandfather strongly identifies with the GOP.
But 82-year-old Wayne Walton said that won't stop him from watching the Democratic confab on television and straining to catch a glimpse of his granddaughter.
"I've never voted for a Democrat because if they want me to vote for them, they need to get on my side of the ballot," the Loogootee, Ind., resident said with a chuckle.
"But I think (Andrea Walton) is a wonderful young lady," Wayne Walton said. "As for her being on the other side of politics, it's not a problem. It's her privilege. This is America."
Subscribe to the Courier & Press or The Gleaner
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Bullet-Hard Buttress All sport climbing2 routes in area
- 100% Sport
- Grades: AU
- Ascents: 7
Did you know?
Did you know that you can create an account to record, track and share your climbing ascents? Thousands of climbers are already doing this.
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Roof Vertical Overhung NE
Small section of wall right next to the walking track, about 50m before you get to Shotgun Wall. These routes get shade before Shotgun, so are good for early afternoon.


text:
tag:blogger.com,1999:blog-4213956784784062266.post9023696199042650607..comments2015-07-01T20:51:38.656-04:00Comments on Bike Snob NYC: BSNYC Field Trip: Prelude to the IMBA World Summit (Part I of XXXVI)BikeSnobNYChttp://email@example.com:blogger.com,1999:blog-4213956784784062266.post-67952640984862672512014-08-26T14:52:55.167-04:002014-08-26T14:52:55.167-04:00Your welcome! And we are "Bike [CITY] USA&qu...Your welcome!

And we are "Bike [CITY] USA" where we ride other peoples (stolen) bikes!

Gawblessyu!

firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-49162115430635088982014-08-26T06:56:55.839-04:002014-08-26T06:56:55.839-04:firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-9314235624152881892014-08-26T06:46:54.037-04:002014-08-26T06:46:54.037-04:00"When you're a New Yorker, no matter how ..."When you're a New Yorker, no matter how law-abiding you are, you always take note of items you could theoretically steal."

It's not just new amsterdam where this thought percolates through the locals.

Same thing on the West coast, but north of the San Francisco cleave line, emasculated hipsters are rendered inert in their larcenous impulses.semi serious cyclisthttp://firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-5294792734455078562014-08-26T01:59:39.893-04:002014-08-26T01:59:39.893-04:00Selling my Cervelo because after trying this sport...Selling my Cervelo because after trying this sport I think it is not for me. Has 23mm tires that are too harsh for my bum that is not liking the pounding. I am going to stick to cricket, squash, and other games with balls. Tom email@example.com:blogger.com,1999:blog-4213956784784062266.post-46909925773395008142014-08-26T01:54:24.810-04:002014-08-26T01:54:24.810-04:00Elk meat tastes best with artisanal olive oil driz...Elk meat tastes best with artisanal olive oil drizzled on it. Or if you eat it like I do, with plenty of mayo.Jan email@example.com:blogger.com,1999:blog-4213956784784062266.post-28322079001817367702014-08-26T00:41:20.185-04:002014-08-26T00:41:20.185-04:00Samuel-- P. Bateman's antipathy to orange and ...Samuel-- P. Bateman's antipathy to orange and geographical references suggest a Georgia Bull Dog.

But I have a hard time recognizing bull from a dog.

leroyhttp://firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-51208159411909920692014-08-26T00:32:34.192-04:002014-08-26T00:32:34.192-04:00Note to self. Next year decline dog's challen...Note to self. Next year decline dog's challenge to make old back-to-school japes work.

Obedience school drop outs' tastes tend toward the sophomoric. leroyhttp://firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-16565831788143470892014-08-26T00:13:33.745-04:002014-08-26T00:13:33.745-04:00Bateman is probably from Alabama. When they finall...Bateman is probably from Alabama. When they finally get their first pair of shoes on the day of their marriage they buck for a full half hour.samuelhttp://email@example.com:blogger.com,1999:blog-4213956784784062266.post-75831653404286965912014-08-25T23:56:11.674-04:002014-08-25T23:56:11.674-04:00My dog wishes to send condolences to Mr. McFly abo...My dog wishes to send condolences to Mr. McFly about the tragedy that befell the University of Tennessee's driver's ed and sex education programs.

He heard the mule died. leroyhttp://firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-90700745227989889922014-08-25T23:50:23.255-04:002014-08-25T23:50:23.255-04:00My dog told me that there was a scandal down south...My dog told me that there was a scandal down south. Half of the university of South Carolina football team didn't know what state Clemson was in.

Of course, three quarters of the Clemson football team didn't know what state the University of South Carolina was in.
leroyhttp://email@example.com:blogger.com,1999:blog-4213956784784062266.post-57583039886658811652014-08-25T23:42:28.150-04:002014-08-25T23:42:28.150-04:00Dear Mr. P. Bateman-- Hey, how about that dawg. N...Dear Mr. P. Bateman--

Hey, how about that dawg. No wait....

Hey, them dawgs, what about them? No that's not it.

Oh oh oh, I know. What about the dawg?

Still not right.

Them dawgs, how about them?

Hmmm. I better ask my dog.

leroyhttp://email@example.com:blogger.com,1999:blog-4213956784784062266.post-75411699153191911962014-08-25T23:02:59.111-04:002014-08-25T23:02:59.111-04:00Australian kisses - just like french kisses, but d...Australian kisses - just like french kisses, but down underI got yur kisses right email@example.com:blogger.com,1999:blog-4213956784784062266.post-49966071810535005262014-08-25T21:44:49.354-04:002014-08-25T21:44:49.354-04:00punk snot deadpunk snot deadthe email@example.com:blogger.com,1999:blog-4213956784784062266.post-52031261667193557142014-08-25T21:04:20.538-04:002014-08-25T21:04:20.538-04:00I <3 nimble fingered elves. Mmm... Oh here we...I <3 nimble fingered elves. Mmm...

Oh here we go. Thanks a lot for making it obvious how much of a mutard I am. My career is all ass backward next to yours, snobbers. You and every other normal, sane specimen of humanity. I've been ranting pantsless in the streets for EVER already, and it's my first year rolling with a UCI license. Who gets faster with age, anyway?

Er, and one more thing. You know that ladder in the middle of the street you were going on about? That would be the zoom button. Yer smarting phone has one.

Yours.
A smarting alec.

PS. With love. And all due respect, etc. And kisses. Mmmmm kisses. Kisses all round. XXbabble onhttp://firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-56644539503460714772014-08-25T20:57:13.378-04:002014-08-25T20:57:13.378-04:00PB, McFly, is it the Third Saturday in October yet...
PB, McFly, is it the Third Saturday in October yet? Damn that hookah!
Disclaimer. I used to be a Bama fan, but the obnoxious fans, including my mom, wife, and children, turned me into a fan of whoever is playing Bama, the Bayou Bengals, Ole Piss, or the Weegle Weegle War Damn Eagles, next.
I must admit Ole Piss fans tend to stay in the stands longer in a losing effort. But that's only because they all passed out in the first quarter.
That giant sucking sound you may hear on a Fall Saturday is the sound of the Bama fans emptying Bryant Denny if the Tide losing at half time. The game is just an excuse to sit in the RV parking lot, compare Bear tats, and get wasted. And drive home, of course, in the firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-81257164691247334832014-08-25T20:52:57.302-04:002014-08-25T20:52:57.302-04:00now that I think of it, he was from ten & the ...now that I think of it, he was from ten & the security guy made the cars blue & orange for email@example.com:blogger.com,1999:blog-4213956784784062266.post-38199338497970746462014-08-25T20:48:58.363-04:002014-08-25T20:48:58.363-04:00Thanks DB.Thanks DB.Yeah email@example.com:blogger.com,1999:blog-4213956784784062266.post-90135689886095162842014-08-25T20:48:10.611-04:002014-08-25T20:48:10.611-04:email@example.com:blogger.com,1999:blog-4213956784784062266.post-64881809479862216072014-08-25T20:46:23.820-04:002014-08-25T20:46:23.820-04:00Oh and that bicycle box is a happy place because i...Oh and that bicycle box is a happy place because it is next to Nano Brew which has good beer and great falafel burgers.Yeah firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-64329814211263567902014-08-25T20:44:04.001-04:002014-08-25T20:44:04.001-04:00Somewhere close to 100.Somewhere close to 100.Yeah firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-18300151323187738062014-08-25T20:43:12.812-04:002014-08-25T20:43:12.812-04:00Leading somebody out.Leading somebody out.DBhttp://email@example.com:blogger.com,1999:blog-4213956784784062266.post-30659742894376922382014-08-25T20:36:34.926-04:002014-08-25T20:36:34.926-04:00Ha. Ha. Flyover @ 6:34. That's gotta be the co...Ha. Ha. Flyover @ 6:34. That's gotta be the cod.* Mark my words.

*Comet of the day, April 20th 1910.Dead email@example.com:blogger.com,1999:blog-4213956784784062266.post-42615836390298286742014-08-25T20:35:23.011-04:002014-08-25T20:35:23.011-04:00I had a friend who went to university of FL...the ...I had a friend who went to university of FL...the incoming director of security at that time was from U Tenn. To throw down the gauntlet, he had the campus cops' cars painted in volunteer orange, instead of U of FL email@example.com:blogger.com,1999:blog-4213956784784062266.post-90147623204503112012014-08-25T20:11:03.489-04:002014-08-25T20:11:03.489-04:00@PBateman: Them's fightin' words. GO, VO...@PBateman: Them's fightin' words.

GO, firstname.lastname@example.com:blogger.com,1999:blog-4213956784784062266.post-71369863790828748392014-08-25T19:47:46.816-04:002014-08-25T19:47:46.816-04:00What? An article about a trip to Colorado without ...What? An article about a trip to Colorado without talking about weed? Maureen is ashamed of (for) firstname.lastname@example.com


text:
The end of Bellevue, WA-based Action Engine is near. We are expecting to hear more about the situation soon, however, a person close to the company confirmed that on August 12 all of the employees were furloughed, and then two weeks later on Aug. 29, they were officially laid off. Since the mysterious closure, company executives have been busy trying to sell the company. One of the leading candidates is Movius, which was a partner of the company and provides infrastructure to carriers. Also, it was rumored that at some point, Everypoint, also looked at the deal.
More after the jump…
Action Engine develops "on device portals," which provides a platform to content companies to launch mobile applications with advertising support. The timing of the company's collapse is odd given that in a July 22 press release, the company rattled off an impressive list of accomplishments, which included partnerships with big-name brands, such as *AOL*, MSNBC and Sports Illustrated (the release is no longer available on the company's site). It was also rumored the company was working with MySpace and MTV and VH1. Through its partnership with Movius, it gained access to carriers.
Still, the company's past is hardly spotless. In July 2007, the company raised $20 million from investors, including Baker Capital, Northwest Venture Associates and The Spangler Group. However, former investors, like *Intel* and OVP Venture Partners declined to participate in follow-on rounds. In a Seattle Times article, OVP's Chad Waite said: "We lost confidence that the company was going to be able to develop a product on the amount of money that it would take to make a return on the investment…It was too long of a road." In total, the company has raised about $65 million. Action Engine's CEO Scott Silk, who joined the company in 2004, said in the same article: "The company had a brilliant idea but it was early to market. Do you shut a company down because they are doing it right but it's early? No." But apparently, that's what's happening. It's unclear exactly what went on, but is it possible that the newer investors also got impatient? Was the mobile-advertising market not as active as they wished? "We had the top flight customers, and we had a lot of great exposure, but in spite of it all, it boiled down to strategic choices that were made, and they didn


text:
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Welcome to Invictus Books! You have come to the right place for the reading materials that the system does not want you to have! From national socialism, communism and zionism, western philosphy, Hitler, the Nazi's, the infamous SS, and much more....Invictus is your source.NOW ACCEPTING!! ** VISA ** MASTERCARD** DISCOVER ** AND DEBIT
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John James Glossop
1 portrait
© National Portrait Gallery, London
John James Glossop
by Unknown photographer
albumen stereoscopic card, 1858
3 1/4 in. x 6 5/8 in. (83 mm x 168 mm) overall
Given by Terence Pepper, 2007
Photographs Collection
NPG x131830
Click on the links below to find out more:
Sitterback to top
- John James Glossop (1816-1886), Army officer, Justice of the Peace and landowner. Sitter associated with 2 portraits.
Artistback to top
- Unknown photographer. Artist associated with 5519 portraits.
Subjects & Themesback to top
Exhibitions and displays
- Women and the First World War
Until 25 October


text:
Wounded Warrior, 100% All-Natural Topical Skin Ointment, 2 fl oz (60 ml) (Discontinued Item)
By Wounded Warrior6 Reviews
Shipping Weight:?0.24 lbs (0.11 kg)
Shipping Weight
The Shipping Weight includes the product, protective packaging material and the actual shipping box. In addition, the Shipping Weight may be adjusted for the Dimensional Weight (e.g. length, width & height) of a package. It is important to note that certain types of products (e.g. glass containers, liquids, fragile, refrigerated or ice packed) will often require protective packaging material. As such, these products will reflect a higher Shipping Weight compared to the unprotected product.
- Product Code: WWR-55963
- UPC Code: 636667559638
- Package Quantity: 2 fl oz (60 ml)
- Dimensions: 1.6 x 2 x 5.8 in, 0.2 lbs (0.09 kg)
Product Overview
- Heals, Relieves & Soothes Skin Irritations
- A First Aid Kit in a Bottle
- Since 1990
Wounded Warrior is made from wildcrafted or organically grown herbs that are processed in pure grain alcohol. These extracts are then blended into aloe vera gel.
Wounded Warrior is an antiseptic and astringent ointment for the relief of minor skin irritations, insect bites, cuts, crapes and more. It heals, soothes and moisturizes.
Since 1990, thousands of people have used Wounded Warrior.
Suggested Use
Cleanse wound with mild soap and water. Cover affected area with Wounded Warrior and bandage lightly as needed. Apply several times daily for the best results.
When dry, reapply.
Key Topical Uses
Abrasion, acne, blisters, burns, cuts, insect bites, rashes, sunburn and more.
For external use only. If irritation develops or persists, discontinue use and consult a physician. Avoid contact with eyes. Keep out of reach of children.
Wild-crafted or organically grown witch hazel, goldenseal, white cedar, guto kola, yarrow, calendula, comfrey leaf, and lobelia extracted in pure grain alcohol. Blended in an aloe vera gel.
iHerb Customer Reviews
Wounded Warrior is the most wonderful ointment I have ever used. My husband is from Boone, NC, and he said his Mom always used it when he was a child. We got a bottle but it had run out. I was frantic about where to get it until I saw your wedsite. I have given away more than I have used and everyone else raves about it also. I had a 3rd degree burn on my arm, but with Wounded Warrior it healed in record time and is not even leaving a scar. So glad to know where I can get it so my friends, family and I will never run out. Thank you, iherb!!!
Our household uses Wounded Warrior Ointment on every part of our body that has problems, even use it on our dog for hot spots, works wonders. Bug bites, skin allergies, excema, any sore or itching part we put it on & within no time it is better. My dog really appreciates it, better than going for a steroid shot at the Vet. Super fast shipping from iHerb, thank you so much


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Because why wear thongs when you can wear comfier, more stylish footwear?
10 Lightweight Jackets for Spring
Spring has finally sprung, and 'tis the season to give your wardrobe a color-infusion! But brightening up your outfits doesn't mean you have to splurge on new duds; a few affordable, color-saturated accessories can give the clothes already in your closet a major style boost. To help kick up your gear, we've found the cutest accents of all—including affordable handbags, necklaces and earrings—in every color of the rainbow.
Floral-Inspired Beauty Products


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Jackson High School Field Renamed for Dungy
Updated: 10/25/2008 - Jackson High
Updated: 10/25/2008 - Jackson High
Posted: 10/24/2008 - Michigan among top ten states for using seat belts.
Posted: 10/24/2008 - CureMichigan is leading in raising funds.
Updated: 10/24/2008 - They've found 6,700 people so far who haven't paid taxes
Updated: 10/24/2008 - Buying a home may seem like a ludicrous idea to those who are barely able to put food on the table. That could explain why the housing market has been in gutter, that is until recently...especially in Lansing.
Updated: 10/24/2008 - They've avoided layoffs that had been considered unavoidable; but trimming continues
Updated: 10/24/2008 - Closing bell ends wild week on Wall Street.
Posted: 10/24/2008 - Federal judge approves Michigan foster-care deal
Updated: 10/24/2008 - Forces evacuation of neighboring apartment building.
Posted: 10/24/2008 - Enrollment up about 600 students.
Updated: 10/24/2008 - Still down.
Posted: 10/24/2008 - Kid Rock's Detroit label to aid music scholarships
Posted: 10/24/2008 - A 25-year-old man who lives at the house where his mother runs a day care center has been arrested and faces felony drug charges.
Posted: 10/24/2008 - Everything goes at Detroit-area funeral home
Updated: 10/24/2008 - Automaker will begin latest workforce reduction next month.
Updated: 10/24/2008 - Wall Street following falling stocks around the world.
Updated: 10/24/2008 - With less than two weeks to educate the thousands of new voters, election officials want to make sure everyone knows what to do on election day.
Updated: 10/23/2008 - What do you need to do to make sure your house is ready for the winter?
Updated: 10/23/2008 - A more efficient way of distributing the money may be the reason for the increase.
Updated: 10/23/2008 - Let Google do the work for you with a new fancy feature the search engine has added.
Updated: 10/24/2008 - Prosecutor says he needs more information.
Updated: 10/23/2008 - After daylong ups and downs, the Dow settles in positive territory.
Updated: 10/23/2008 - The Salvation Army is taking bell-ringing to a whole new level.
Updated: 10/23/2008 - Automaker will no longer offer some benefits, including 401(k) matches.
Posted: 10/23/2008 - Police: Cop busting drunk driver hit by 2nd drunk.


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Costco Inconsistencies -Prints too bright
Started Jan 16, 2013 | Questions thread
New Member • Posts: 10
Phil Hill wrote:
Sounds like you should just request that they turn off the "mysterious exposure setting" before they begin.
I was hoping someone knew the real name of that setting!
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Freezer Danish Pastry
|Sweet butter
|1 1⁄2 Cup (24 tbs), softened (3 Sticks)
|All-purpose flour
|1⁄4 Cup (4 tbs)
|3⁄4 Cup (12 tbs)
|1⁄3 Cup (5.33 tbs)
|1 Teaspoon
|1⁄2 Cup (8 tbs) (Very Warm At 105 To 115 F)
|Active yeast
|1⁄2 Ounce (2 Packs)
|All-purpose flour
|3 3⁄4 Cup (60 tbs)
1. In a large mixing bowl, beat butter and 1/4 cup flour using a wooden spoon until smooth.
2. On a wet surface, place wax paper and spread the mixture to 12x8 inch rectangle.
3. Shift the wax paper on a cookie sheet and refrigerate.
4. In a saucepan, heat milk slightly.
5. Add sugar and salt and stir until dissolved.
6. Let the milk cool down until lukewarm.
7. In another saucepan, heat water until the desired temperature is reached.
8. In a large bowl, pour the warm water and sprinkle with yeast; stir until dissolved.
9. Stir in the lukewarm milk mixture, egg and 3 cups flour.
10. Using a wooden spoon beat the mixture until smooth.
11. Add rest of flour and mix with hand until the dough leaves side of bowl.
12. Cover the dough and refrigerate for 1/2 hour.
13. Lightly flour a pastry cloth.
14. Turn out the refrigerated dough on the prepared pastry cloth.
15. Using a covered rolling pin, roll the dough into a 16x12 inch rectangle.
16. Place the chilled butter mixture on half of rectangle dough; discard the wax paper.
17. Fold other half of dough over butter and pinch the edges to seal.
18. Keep the fold on to your right and roll again to form a 16x8 inch rectangle.
19. From the narrow side or short side, fold the rolled dough into thirds to form three layers.
20. Warp the folded dough with foil and chill for 1 hour.
21. After 1 hour, roll and fold again, seal edges and chill for 30 minutes.
22. Repeat the rolling, folding and sealing process.
23. Wrap in foil and refrigerate for 3 to 12 hours.
24. Cut the cold pastry into 3 equal parts.
25. Wrap each portion individually in a foil, seal and label before freezing.
26. Use 1/3 for making Cherry Pinwheels and 1/3 for Cinnamon Bear Claws or store at 0° F for several months


text:
How about we just have Cueto go 7, then Chapman for 2? Ok?
as expected.. lots of drama (because it took long till they made it public and because of bakers comments) but at the end it was like most fans expected...
I want to see the first time a Cincinnati team advance in post-season play
(last time something like that happened I was to young, couldn´t speek english
and never heard of baseball and american football)
With Cueto's history of being injured, and the fact that he left a playoff game early already, why would Leake, our fifth starter, be the only other starter on the roster for tonight. What if Cueto goes down..again???
OTOH, it probably doesn't matter much. Logan probably gets left off the roster for the next round. It's kind of nice to let him be on the WC roster (Same with Robinson)... Dusty is able to get his loyalty points in for this game.
I guess if Cueto gets in trouble and another starter has to bail him out, we are in deep doo doo anyhow. I have no problem with Leake being the backup starter or emergency long man if this thing goes 20 innings.. That said, I would've probably put another starter on before Logan if it was up to me...
Edit: Glad to see Duke in there, he's a useful arm, when used strictly as a loogy
Thank you Walt and Bob for bringing winning baseball back to Cincy
Nov. 13, 2007: One of the greatest days in Reds history: John Allen gets the boot!
I agree that I think Corky should have been in there.
He has a small sample size, but I think he has been swinging the bat pretty well lately.
9/29 He had 1 AB with a double and 2 RBIs
9/10 He had 2 AB with a double and 1 RBI
8/7 He had 2 AB with 2 doubles and 2 RBIs
Those are the last 3 times he has had ABs (according to ESPN), but I feel that he adds more versatility to this team than Hannahan.
Hannahan is just another lefty bat with no power and can play the IF. I think it can be argued that we have Izturis to fill in for any IFer that is hurt. Corky gives us a 3rd catcher and a decent power righty bat. Think about it, you have to have decent power to hit a double when you are Corky Miller. This way we can PR Billy more confidently too.
2015 Attendance 2-1 (4/6, 4/7,4/24)
2014 Attendance 1-3 (3/31, 4/12, 8/14)
2013 Attendance: 6-0 (4/3, 4/16, 4/17, 8/3, 8/21, 9/7)
Plus, I believe Bailey is nursing a sore leg? That probably played a part in the decision making process.
Thank you Walt and Bob for bringing winning baseball back to Cincy
Nov. 13, 2007: One of the greatest days in Reds history: John Allen gets the boot!
BungleBengals (10-01-2013)
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Originally written on AFC East Daily | Last updated 12/2/12
The Arizona Cardinals will be starting sixth-round rookie quarterback Ryan Lindley Sunday when they play visitor to the New York Jets, and the Jets don't expect the Cardinals to leave much to chance. "They have a rookie quarterback, so they are going to try to keep the game plan conservative — run, run, run and play-action," Jets linebacker David Harris told Eric Allen of NewYorkJets.com. If you thought the Jets' offense was anemic, you'll get a major dose of reality when the Cardinals take the field at MetLife Stadium Sunday. The Cardinals have given up a league-most 46 sacks and have the worst third-down offense in the league, converting on less than 29 percent of third downs. Additionally, Lindley will be taking snaps from Rich Ohrnberger, who is making his first start of the season in place for the injured offensive co-captain Lyle Sendlein.Arizona and its 30th-ranked rushing offense will hope to exploit the Jets' 30th-ranked run defense, because if New York stuffs the run and m...
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Motivational speakers need not apply here
January 12, 2013
The New Year is well on its way and packed full of resolutions, many of which already are at the side of the road covered with dirty snow or being blown away by the blustering winds.
Alas, if only those casting away these broken dreams had gone to a motivational speaker, they could be pounds lighter, their diets healthier, lives happier, relationships flourishing, homes cleaner, children better mannered, careers flourishing, checking accounts larger, business escalating and the list goes on.
Even I, at this very moment, could be living on a diet of spinach and kale and spending each morning doing sit-ups while listening to a tape guaranteeing that I could learn to speak Chinese in two weeks. Sadly, I haven't sat through a dinner of creamed chicken and peas over biscuits and heard a motivational speaker since the Monday nearly a decade ago when I turned off my alarm clock set for 5:30 a.m. and went back to sleep.
I can hear motivational speakers from across the country, or at least the one or possibly two (so I'm a dreamer) who might be scanning this, on the verge of sending me a scathing note. I won't be bothered by this because I do remember one of the tidbits I heard from my motivational speaker days: Do not be bothered by criticism and keep moving forward.
I did learn from the motivational speakers of my adult life, but it was those of my childhood who put me on the path I walk today. It was my mother who made me aware of the importance of thank you notes, planning ahead, being respectful, and good old-fashioned manners, which can lead to a happier, more fulfilling life. It was my mother who motivated me to stop fighting with my brother. "You can clean the windows, one on the inside, the other on the outside, until you learn to get along with others." It was my dad who encouraged me to follow my dreams but also motivated me to get a job done quickly and not put it off. "I told you this morning you couldn't go on that date until the lawn is mowed."
There are many motivational speakers and just as many ways to be motivated. Maybe I can learn Chinese in two weeks.
Joyce Ore writes delightful stories about life with a dose of humor and sprinkle of nostalgia. Her column appears Saturday in the Tribune.
Copyright © 2015


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Download the full report on the prostitution and Trafficking of Native women in Minnesota here.
Melissa Ditmore, editor of The Encyclopedia of prostitution and Sex Work, met Lovelace in 2001.
prostitution opponents cite scientific studies; supporters of legalization find flaws in the data.
1530s, from Middle French prostitution and directly from Late Latin prostitutionem (nominative prostitutio), noun of action from past participle stem of prostituere (see prostitute).


text: Vegan Dosa Cart Crowned Street-Food Champion October 1, 2007 Thiru "Dosa Man" Kumar's vegan cart won New York City's Third Annual Vendy Awards on Saturday. Muhammed Rahman, winner of the People's Choice award, tells how it's done, and Judge Mo Rocca talks about the joys of street food. Listen Loading… Playlist Download Embed Embed Close embed modal <iframe src="http://www.npr.org/player/embed/14852909/14852893" width="100%" height="290" frameborder="0" scrolling="no">


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As a christian, the whole idea is waaaay more offensive than the SNL satire.
simply a money grab and political fodder. blasphemous at best... seriously ..
How do you know that ezra ? It hasn't even been written...lol B.O. may write a beautiful retelling of the scriptural account & draw people to the Lord. ( I doubt it, but who knows how the will Holy Spirit work ?
Speakeasy is a blog covering media, entertainment, celebrity and the arts. The publication is produced by Barbara Chai and Jonathan Welsh with contributions from the Wall Street Journal staff and others. Write to us at email@example.com or follow us on Twitter at @WSJSpeakeasy or individually @barbarachai.
Content engaging our readers now, with additional prominence accorded if the story is rapidly gaining attention. Our WSJ algorithm comprises 30% page views, 20% Facebook, 20% Twitter, 20% email shares and 10% comments.


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Book Search
Multinational Corporations and the Third World (RLE International Business)
Series: Routledge Library Editions: International Business
This book is a comprehensive study of the role of multinational corporations in the economies of the Third World. It begins by providing a comprehensive overview of the activities of multinational corporations and the main areas of research and debate. It goes on to discuss specific sociological,...
Published March 21st 2014 by Routledge
Human Evolutionary Genetics
2nd Edition
Now in full-color, the Second Edition of Human Evolutionary Genetics has been completely revised to cover the rapid advances in the field since publication of the highly regarded First Edition. Written for upper-level undergraduate and graduate students, it is the only textbook to integrate genetic...
Published June 25th 2013 by Garland Science
Global Japanization?
The Transnational Transformation of the Labour Process
Series: Routledge Library Editions: Japan
Global Japaniziation? Brings together research from North America, Japan, Europe and Latin America to analyse the influence of Japanese manufacturing investment and Japanese working practices across the global economy. The editors present original case studies of work reorganization and workers'...
Published March 22nd 2013 by Routledge
Qualitative Complexity
Ecology, Cognitive Processes and the Re-Emergence of Structures in Post-Humanist Social Theory
Series: International Library of Sociology
Offering a critique of the humanist paradigm in contemporary social theory, Qualitative Complexity is the first comprehensive sociological analysis of complexity theory. Drawing from sources in sociology, philosophy, complexity theory, 'fuzzy logic', systems theory, cognitive science and...
Published February 13th 2007 by Routledge
Biology of Disease
Biology of Disease describes the biology of many of the human disorders and disease that are encountered in a clinical setting. It is designed for first and second year students in biomedical science programs and will also be a highly effective reference for health science professionals as well as...
Published October 26th 2006 by Taylor & Francis
Including the Gifted and Talented
Making Inclusion Work for More Able Learners
This single volume presents the views of experts from the field which challenge the assumption that educational inclusion relates only to those pupils with learning difficulties. In this book, the authors examine the extent to which a truly inclusive context can provide a challenging...
Published December 15th 2005 by Routledge
Journal Article: Labour turnover and management retention strategies in new manufacturing plants
Published March 1st 2004 by Routledge
Human Evolutionary Genetics
Origins, Peoples and Disease
Human Evolutionary Genetics is a groundbreaking text which for the first time brings together molecular genetics and genomics to the study of the origins and movements of human populations. Starting with an overview of molecular genomics for the non-specialist (which can be a useful review for...
Published January 4th 2004 by Garland Science
Series: Studies on Neuropsychology, Development, and Cognition
This volume will look at the history of trepanation, the identification of skulls, the tools used to make the cranial openings, and theories as to why trepanation might have been performed many thousands of years ago....
Published January 1st 2003 by CRC Press
Forest Certification in Sustainable Development
Healing the Landscape
From recycled products to organic food, the movement to be "environmentally friendly" is now expanding into the forestry field. Recognizing this impact, Home Depot has committed to giving preference to selling "certified wood," proven to come from forests that meet certain biological and social...
Published September 27th 2000 by CRC Press


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You can now invite anyone to meet at your favorite Starbucks.
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27 year old woman | New York, NY, USA | Seeking men 25-35 within 3 miles
Active within 5 days
Hey there!
Hi! I'm Debby and I work in Downtown Manhattan as a financial- IT recruiter and live in Hoboken. I think laughter is highly underrated.I'm an animal lover who has a soft spot for horses and dogs. I absolutely adore Dave Matthews Band, South Park and Parks and Rec. I've been reviewed as "witty" more than once on AirB&B. I love trying new things. I would classify myself as pretty outgoing and laid back. I use sarcasm with great frequency. I am super preppy. I have absolutely no sense of direction and am a completely uncoordinated dancer. I went to a college where the mascot, the vixen wears pearls. Once in a while I can be pretty blunt, though not in a "Jersey Shore" sort of way. I far prefer a glass beer to a glass of wine. While I can often be a complete goof-ball/ dork, intellectual conversations are very important to me. I dislike ostriches, and emus because they look like ostriches. If you can get passed my irrational large bird hatred say hi! I find intelligence to be enormously attractive.I'm looking for a guy who's easy going and loves to laugh. He should understand that chivalry isn't dead. He'll need to understand sarcasm as I'm full of it. A guy who loves dogs. I consider being honest, caring, and kind to be completely necessary in all walks of life.
Alumni connections , Coffee and conversation , Business networking , Dining out , Fishing/Hunting , Hobbies and crafts , Movies/Videos , Music and concerts , Exploring new areas , Performing arts , Playing sports , Political interests , Religion/Spiritual , Travel/Sightseeing , Video games , Wine tasting
Golf, Skiing, Swimming
I exercise 3-4 times per week.
I have Fish
I like Dogs, Horses
So I have a frog. Long story short, he was mislabeled at the pet store and I ended up with a crazy African-clawed dwarf frog who kills anything near it and lives to be 25. Any takers?
Concerts, (especially in the summer), trying just about any new restaurant around the city
Sweet Briar College, Sweet Briar, VA
Coffee/ Espresso, animals, snow sports, penutbutter, polos, non-light beer
I try my best to make time to hang out with friends whether it's out at some new bar or watching part of a Netflix series on a rainy day. I love being outdoors especially when it's nice out. I'm a concert fan, and enjoy travelling to new places.
NY Times...and Cosmo...I'll admit it.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'5" (165cms)
|5'9" (175cms) to 8'11" (271cms)
|Body type:
|No preference
|No preference
|Dark brown
|No preference
|No Way
|No preference
|Social Drinker
|Social Drinker, Regularly, Moderately
|Other profession
|No preference
Talent Acquisition Specialist/ Head hunter/ Senior Technical Recruiter...whatever you'd like to call it.
|I'll tell you later
|No preference
|Never Married
|Never Married
|Have kids:
|Wants kids:
|Definitely, Someday, Not sure, Probably not
|White / Caucasian
|Black / African descent, Middle Eastern, Pacific Islander, White / Caucasian, Other
|Agnostic, Atheist, Christian / Catholic, Christian / Protestant, Jewish, Spiritual but not religious, Christian / Other
"Culturally Jewish"
|Bachelors degree
|Bachelors degree, Graduate degree, PhD / Post Doctoral
Majored in Psychology but still fall a bit short in the mind reading department.


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Fred George Whittingham
Position: LB-G
Height: 6-1 Weight: 240 lbs.
Born: February 4, 1939 in Boston, MA
Died: October 27, 2003 in Provo, UT
High School: Warwick
College: BYU, Cal Poly-San Luis Obispo
Weighted Career AV (100-95-...): 19 (4926th overall since 1950)
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Female , 18-21
Feeling nostalgic
wow... been forever since I've been on..
Last Seen Apr 20, 2014
Member Since Feb 10, 2012
Favorite Quote I'm in love with a fairy tale, even though it hurts. And I don't care if I lose my mind...I'm already cursed
- 100% Afrikaans
Horoscope Scorpio
Special day
Books too many to say
Music TDG, Seether, Staind, Trapt, Linkin Park
Movies Zombieland!!!! (and beauty and the beast) plus the matrix, newsies, and a bunchmore.
Local Time July 4th, 1:13 PM
Try I flash back and see A memory... Of a girl crying in a corner, wishing they didn't scorn her. Breaking down inside, looking for a place to hide. Of a... [more]
I Broke My Promise... A while ago I made a promise to literally the only person who cares about me irl not to cut. And I actually managed it for a while. Then,this week...well, I broke my promise... It was a mistake… [more]
I Hate My 'dad' my whole life ive been abused by my dad. hes not the only one but, for the most part his has been the worst, not to mention the most consistant, and the most ignored.... my mom divorced my dad b… [more]
At Least Once A Day... No, I'm not a wimp, i don't cry because my life is so very horrible or this or that. I just cry. Most of the time I don't have a reason. But ever since i was little I've cried at least once a day a… [more]
Took It, Mostly True, Now Just One Question... You Are Geeky You are highly unique and quite brilliant. You have a few obscure interests that you pursue without abandon. It's likely that you are smart and interested in cutting edge te… [more]


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Video: Tags: space
A tag is a word or phrase that helps you find video clips with similar content. View all tags »
NOVA | The Spacetime Lemonade Stand | PBS
Thirsty for understanding? See how well people on the street can explain spacetime. 02:18
NOVA | Finding Life Beyond Earth Preview | PBS
Scientists are on the verge of answering one of the greatest questions in history: Are we alone? 00:30
PBS NewsHour | Juno Spacecraft Lifts off for Jupiter | PBS
Full Program: NASA's Atlas V rocket will lift off at 11:34 am ET. 02:35:38
PBS NewsHour | Asteroid Is a Dance Partner for Planet Earth | PBS (#10120)
Asteroid Is a Dance Partner for Planet Earth 04:31
The McLaughlin Group | 7/22/2011 | PBS (#2930)
Full Program: Issues: Big Deal or Big Fizzle; Rupert's Humble Pie; Shuttle Over and Out; Consumer Reports. 27:52
PBS Presents | 400 Years of the Telescope - Preview | PBS
Chronicle of the telescope's history visits the world's leading astronomers, cosmologists and observatories. NOVA's Neil deGrasse Tyson narrates. 00:31
PBS Presents | Phoenix Mars Mission: Ashes to Ice - Preview | PBS
This program chronicles the story of the Phoenix Mars Lander, which launched in August 2007 and is scheduled to land on the Martian surface on May 25, 2008. 00:31
PBS NewsHour | Monday, July 11, 2011 | PBS (#10107)
'Slow Going' Debt Limit Talks Center on Taxes, Entitlements 54:37
PBS NewsHour | As Shuttle Retires, What's NASA's New Mission? | PBS (#10107)
As Shuttle Retires, What's NASA's New Mission? 12:44
PBS NewsHour | NASA's Shuttle Era Winds Down With Bittersweet Moments, Grocery Run | PBS (#10106)
NASA's Shuttle Era Winds Down With Bittersweet Moments, Grocery Run 04:26
PBS NewsHour | Mock Mission to Mars Tests Rigors of Long-Distance Space Travel | PBS (#10105)
Mock Mission to Mars Tests Rigors of Long-Distance Space Travel 10:14
PBS NewsHour | Miles O'Brien on the Last Shuttle Launch | PBS (#10105)
Hari talks to Miles O'Brien about the space shuttle program, on the eve of its retirement. 05:36
History Detectives | Moon Museum Update: Searching for John F. | PBS (#901)
An update on our Moon Museum story asking viewers to help us solve the mystery of John F. 01:30
History Detectives | Space Boot | PBS (#801)
What does this odd-looking boot have to do with America's first steps in space? 16:00
History Detectives | Satelloon | PBS (#801)
Could this square of metallic material be part of America's first satellite program? 18:15