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How We Met || Chapter 2 || A Steve x ReaderChasing. Running. Laughter. Falling. Falling. FALLING.You woke up with a shudder, the small bed creaking underneath you as you sat up. You looked at your room mate and best friend, (Friend), who was still sleeping soundly and sighed. These bad dreams have been coming regularly, and you weren't sure what was sparking them. Rubbing your face in your hands, you reached out to the journal laying on you beside table. You began to write:Dear Mum, This is my tenth letter to you, believe it or not. Three weeks I've been aboard this ship in the sky. It's kind of intimidating actually, with all the techy doohickeys. You wouldn't like it, but then again, you always thought superheroes were just a myth. Turns out their not. I can only help but wonder why I get nightmares when I'm sharing a roof with these super people. Maybe it's because I see something in them. Each and every one of these people on board have had some horrible past event happen to them. I can se
How We Met || Chapter 1 || a Steve x ReaderToday is the day. The day you're getting married to the one and only Steve Rogers. To be (Name) Rogers would be the greatest thing to ever happen, and you couldn't believe how starting off working at S.H.E.I.L.D. was how this all started.~Two Years Back~"Alright. I've chosen this housekeeping staff very particularly for the heros we have coming in. It is your job to clean and cook for these honorary guests. It is not your job to get to know and distract them. You do not need to know their favorite color, only if they're allergic to peanuts, shellfish, or carrots. These are a hardworking, busy bunch of extraordinary people, and I expect the best from you." The Housekeeping Director was extremely strict, never allowing the small team to have more than a 10 minute break each day. They barely had time to even sleep.You were a part of this team. It wasn't like you wanted to clean up after a bunch of snobbish, bossy superheroes. It was more like you had to. Mone
How We Met || Chapter 3 || A Steve x ReaderAll there was, was warmth. It encircled you like a big, strong blanket. But, how could a blanket be strong?You opened your eyes to see that you were still in Steve's bed and his arms were wrapped around your waist. He was still asleep and he looked so peaceful, a big difference from the face that you could tell has seen war. They didn't call him the Super Soldier for nothing. Your head was lying on his chest and your legs were entwined in his.Sleeping in his bed worked. The bad dreams didn't come. Of course, you did have a dream, but it was a good one. It included not being a maid on this ship, but working in the control room. It was a job you would prefer to have. No cleaning. No cooking. No extremely stupid maid dresses. It was nice and perfect.An alarm beeped on the bedside table and from looking at Steve's face you could tell he was waking up. His face scrunched up from having the sharp beeping cut through to his subconscious mind and he slowly opened his eyes. Before he did any


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Dos Santos says UFC 121 winner will get knocked out
Related MMA gear from the UG Store
Recent Comments »
10/24/10 12:08 PM by Hulk74
Yea and everyone thought JDS would KO roy Nelson
10/24/10 12:01 PM by Drummeryan
JDS all day.
10/24/10 11:28 AM by Invulnerablo
Cigano will win!The amercian fighter Cain, will start better but will end bad.
10/23/10 8:33 PM by DontBanMeBro
yes really...how can a fan say JDS will KO Cain?u have to base it on past performances and so far hes KOed a couple of goons...nice uppercuts, caught gilbert with a nice counter but just saying. he teed off on nelson for 15min and couldnt come closeimagine that same fight but it being vs Cain instead. JDS would be on his back as often as cain wanted, JDS would not have hurt cain on the feet and cain woulda KOed him for sure if he landed the shots nelson did. just IMO fellas, take it or leave it...no need to get all Cr4zy
10/23/10 6:38 PM by BispingPoppedMyCheery
LOL JDS better PRAY Cain wins because is Frate wins he will be eating take downs, then the rape party begins for JDS....
10/23/10 6:35 PM by gorillagrappling
Took JDS years of taking beatings from Nog to "get better" at fighting him. Cain destroyed him. ???? JDS is a fad. People were saying the same junk about Gonzaga. Then it was Carwin. Now they are saying those things about Cain. Lesnar will beat them both and they will be just like the rest of the "next big things." When Brock wins tonight, I think we are going to have to just get used to having him as champ for a while.
10/23/10 6:30 PM by SeditiousViciousness
Hell yeah JDS!!! I love the confidence and I love the Manhoef-like fury he brings into the cage. Doesn't matter who wins tonight I can't wait to see them face off with Junior.
10/23/10 6:28 PM by CRE
When Jr. has nightmares he sees the ghost of Montezuma aka Cain Velasquez 8 punches and a guard pass in 3 seconds did this

subset: commoncrawl


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He only hs 2k gold which takes 2 days to reset I think, that's the only limitation. This will also make him work as an endless pack mule if you have a lot of gold and know your reset timer. Sell stuff to him in a dungeon, buy it back in town.
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PSU recommendation for GTX280/260
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Join Date: Dec 2005
Location: Barksdale AFB, La
Posts: 1,238
Re: PSU recommendation for GTX280/260
Originally Posted by
Ninja Prime
I'll never buy anything but Corsair power supplies again, best PS ever. Corsair power supplies are rated on actual power, the 620w, which I have, it equal to a 750w 80% efficent PS from anyone else. 620w should be plenty for any single card.
I think you're misunderstanding the efficiency rating. It has nothing to do with power output, so much as power input.
For instance, my SeaSonic S12 500 can output 500W (if you max out every rail). It's also rated as 80+ efficient, so for this argument, we'll use 80% as it's efficiency.
Since energy is lost in the form of heat, the PSU has to draw more power from the wall than your PC actually needs. So, if your PC needs 200W, and the PSU is 80% efficient, the actual power draw from the wall would be 250W. No PSU is 100% efficient, and most high quality PSUs, including SeaSonic, PC P&C, and several others, can output their rated power.
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text: Items 1 to 12 of 60 total View 12 / 24 / 48 1 / 2 / 3 / 4 / 5 Next Quality By Andrew on 5/12/2015 Andrew would recommend this product to a friend great heater when paired with the Neptune Apex system very consistent temps perfect for a system By Joseph on 4/25/2015 Joseph would recommend this product to a friend So for people heating there tank precisely using a controller such as digital aquatics, these are the way to go. Very accurate and even heat. Reliable, and durable. I used 3 500w heaters for my 350gallon. Excellent product for use with an aquarium controller By Paleoreef103 on 4/23/2015 Paleoreef103 would recommend this product to a friend My temperatures are rock solid in my tank thanks to this product and my Reefkeeper controller. It is important to know that this product DOES NOT include a built in thermostat so make sure you have a temperature controller or a full aquarium controller with temperature probe. It heats up quickly and seems to be incredibly tough, though I have not tried to test its durability. Nice heater By Ewan on 2/12/2015 Ewan would recommend this product to a friend This heater works great! I have it running off my apex and it keeps my temps very stable. I use one 500w one my 180 and it's perfect, it also fits great in my sump due to its small size. The others I looked at where too long for that amount of wattage. Works Great! By Wade on 2/10/2015 Wade would recommend this product to a friend I have two of the 800w units on my sump, they keep the temp perfect! Built To Last! By Steve on 1/6/2015 Steve would recommend this product to a friend This heater is very durable, corrosion resistant, and at a great price. What more could you ask for? good value By George on 12/15/2014 George would recommend this product to a friend Decided to get the 500w without the controller because I was going to hook it up to an apex systems and it works great. Don't waste your money By Eddie on 12/5/2014 Eddie wouldn't recommend this product to a friend I bought the 500 watt model and within a month I started feeling stray voltage in my tank. Based on the reviews at the time, I assumed I had a lemon. I tossed it and replaced it with the 300 watt model. Same thing happened with that one also. The unit comes very nicely packaged and appears to be of decent quality, but after minimal use the lack of quality is quite apparent. I had a Won Bros Pro Heat Titanium heater last me over 7 years, but they also appear to have dropped in quality. I gave the Cobalt Neo-Therm a shot as well. The 150 watt model works great, but the 200 watt model has quality issues with stray voltage and/or blowing up. It looks like I'll be sticking with the Eheim JAGER TruTemp. If you value your life and your livestock, I recommend you do as well. Great Product By PotteryMan on 11/18/2014 PotteryMan would recommend this product to a friend I purchased the 500 watt heater and run it using a controller. Works great. First Titanium Heater By Lee on 11/15/2014 Lee would recommend this product to a friend This was my first titanium heater I ever purchased (800watt). I love the idea of not worrying about it breaking/cracking. I hooked it up to a ranco controller that came with a setup I purchased and it is maintaining accurate temperature. No complaints. Very happy. great By dominick on 11/13/2014 dominick would recommend this product to a friend I have the finnex 800 watt and it keeps my 265 gallons of water at a steady 80 degrees im using reefkeeper to control it best heater iv purchased!no more glass for me lol. Just Installed By Tom on 11/8/2014 Tom would recommend this product to a friend I live in Wisconsin and my current 150 Watt wasn't doing the job. I wanted something small to fit in my sump Refugium. This was the smallest I could find. The 300 watt has no problem heating my tank. I use the Apex to control it. Write Your Own Review You're reviewing: Finnex Deluxe Titanium Heating Tube *How do you rate this product? *Would you recommend this product to a friend? Yes No *Nickname *Summary of Your Review *Review Submit Review


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264 Lotus blogs updated hourly. Who will post next?
Latest 7 Posts
IBM Domino and Java problem with old applets
Mon, May 25th 2015
Moving on with Excel Export part 6 : But now we Import
Fri, May 1st 2015
Moving on with Excel Export part 5 : XPages Export
Sun, Mar 29th 2015
Moving on with Excel Export part 4 : XPages Export
Wed, Mar 18th 2015
Moving on with Excel Export part 3 : XPages Export
Thu, Mar 12th 2015
Moving on with Excel Export part 2 : XPages Export
Tue, Mar 10th 2015
If your user want reports in Excel you should read this
Mon, Mar 9th 2015
Top 10
HTTP Server is waiting for threads to finish: the wait is over
Wed, May 14th 2014
IBM Domino and Java problem with old applets
Mon, May 25th 2015
Moving on with Excel Export part 6 : But now we Import
Fri, May 1st 2015
News from IBM ConnectED15
Mon, Jan 26th 2015
Holiday Hack: Get some XPage power in old Notes apps
Wed, Dec 31st 2014
The new keylogger function in ios8
Tue, Sep 30th 2014
2014 a year of change
Wed, Dec 31st 2014
Another great developer book found
Tue, Jun 10th 2014
Internet of things is that something to care about
Wed, Aug 13th 2014
Creating an easy XPage keyword bean
Thu, Sep 4th 2014
Recent Blog Posts
IBM Domino and Java problem with old applets
Mon, May 25th 2015 9:35a Fredrik Norling
All the old Java applets that is YES in some old apps not yet converted used got another problem today. They are now blocked by Oracle because the code signing certificate is outdated, it seams like when they where updated to work with Java 1.7 45 the person who resigned them did that with an old certificate and now that cert is outdated and has been so for 1 month. If IBM or you want to keep track on when your code or SSL certs exires QNova Systems contract management system works really gre
Moving on with Excel Export part 6 : But now we Import
Fri, May 1st 2015 4:13a Fredrik Norling
The previous 5 steps in this series (part 1 part 2 part 3 part 4 part 5) has been getting data out to excel in different ways this part will show you how to get data back into Domino again thru your XPage, this will give you the possibility to roundtrip data handling. Export all customers mark the rows you have changed and re import the data. Because Apache POI is installed on the server as an OSGI we have access to these classes in all java code on the server and that is what I'm going t
Moving on with Excel Export part 5 : XPages Export
Sun, Mar 29th 2015 2:27p Fredrik Norling
In the previous parts (Part 1 Part 2 Part 3 Part 4) we covered plain export, styling your exports and doing selective exports. Today I want to show you how to create more advanced and flexible way to get your data using a java object that we use for the export. We start by creating 2 java classes one for the export and one of the Export Data Then in each class add implements Serializable and the private variable on the row below. This is so the java VM can swap the data out disk if needed.
Moving on with Excel Export part 4 : XPages Export
Wed, Mar 18th 2015 2:38p Fredrik Norling
The recent parts of this series has shown you how to create excel exports from a view and also changing the layout of the reports with headers and logos. This post will show you how to filter the data in your excel reports both using keys and fulltext searches. Let's get started. To get some filtered export we add an combobox into our XPage and in this case to show both a Export with a key and search we have two buttons for the different export options. The code behind the com
Moving on with Excel Export part 3 : XPages Export
Thu, Mar 12th 2015 6:20a Fredrik Norling
Making you report look a bit nicer with some formatting. Excel reporting from views can be so dull and boring the XPages for POI can give you more options in this matter and help you create some design to your report. 1. Customizing your template Because POI is using a copy of you template you can customize your temple with logos and predefined information. We need to import this new template and change the startRow and template name In this case we start at row 12 below the logo and
Moving on with Excel Export part 2 : XPages Export
Tue, Mar 10th 2015 4:38a Fredrik Norling
In my last post I wrote about how to in some simple steps generate an automated export of an view to excel. In this post I will show you how to fine grain this using the excel component instead. Start by creating a blank excel file note what the sheet you want to place data on is called usually Sheet1 if you have an english version of Excel. Save and import it as a file resource in the database, name it export.xlsx Now create a new XPage add a button and the Excel component POI Workbook
If your user want reports in Excel you should read this
Mon, Mar 9th 2015 5:23p Fredrik Norling
XPages did get a great addon more than a year ago to be more exact 13:th of September 2013. It was when C hristian Güdemann uploaded the first version of POI for XPages. Apache POI is a rather old apache project, 13 years to be exact. And there have even been a Notes in 9 show by Paul Calhoun on how to use the standalone version of Apache POI. But Christians version makes everything that much simpler to get the Excel file out to the end user, start by going to poi4xpages.openntf.org/ or ess
News from IBM ConnectED15
Mon, Jan 26th 2015 7:30p Fredrik Norling
Some of the news from IBM Connect IBM releases early access to IBM Verse. http://ibm.co/1BfM4S1 IBM Verse will come an an Domino solution for on premise deployment later this year The Domino HTTP engine will get more updates that the previous released updates with SHA2 and TLS 1.0 It will get new HTTP security options as TLS 1.2, PFS and AEAD the IBM HTTP server addon released with Domino 9 will be deprecated The NSF Datastore will get updates that we have all wanted for a long time. View I
Part 2 of Partial Refresh in Notes Forms
Sun, Jan 25th 2015 10:53a Fredrik Norling
I couldn't actually accept myself defeated in the battle to get partial refresh into old school Notes applications. And after a second look at my code I found a way, so I rewrote the javascript library to be a javascript object class so all calls are made inside the class. So now partial refresh of the entire form tag is the standard way of refresh but you can also narrow the refresh to everything inside a div or a table sell if you want to. And Serverside refreshes from a QuerySave agent
2014 a year of change
Wed, Dec 31st 2014 1:59p Fredrik Norling
Looking back at 2014, I see the year that XPages really got accepted as the primary language for Domino. IBM Bluemix got launched and the response was no XPage support in Bluemix, but in the last 2 months we saw that IBM had changed their minds and now there are talking of some kind of support for xPages apps in Bluemix. Great IBM that will get the community to start using the service even more if you can deploy your apps in a real scalable App Engine. The Domino OpenNTF API, evolved and have l
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Fia's First Halloween
Tuesday, November 1st, 2011
Okay, technically her first Halloween was last year, but this is the first time she trick or treated. We went to this great street nearby in Silver Lake, where they close off traffic and the homeowners go all out with decorations, themes, etc.
Fia was Abby, from Sesame Street. But to be diplomatic, she carried an Elmo basket.
She didn't understand that once you put the candy in your basket, you get to keep it. So at every house, she tried to give her candy back. Was really sweet actually.
We managed to do the whole block and get back home in less than 45 minutes, which was perfect for bedtime. And, it was a beautiful night. What a treat for us. We barely dodged that winter storm in New York. I hear some places in New Jersey had to cancel Halloween. Boo—Hoo.
Show me your pictures everyone. Want to see!
Add a Comment
Tags: abby, Elmo, Halloween, Holiday, Sesame Street, trick or treat | Categories: Fearless Feisty Mama, Moving to Los Angeles


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Be the creature from the deep lagoon! Deep Sea Creature mask is monstrously detailed and horrifyingly authentic with buggy red eyes and hideous teeth surrounding an articulated mouth that moves as you speak. Utterly convincing and worthy of a part in Pirates of the Caribbean!
Set sail for an eternity of treasure hunting when you wear this Zombie Pirate Men's Costume on Halloween. Green tattered coat comes complete with a creepy character mask, matching head scarf and a belt. There's no turning back once you board this ship!
Create your own kind of spirit with this Ghost Ship Pirate child costume. The tattered gray and black shirt features a detachable chest piece, spooky half mask with attached scraggly hair, waist tie, black bandanna, boot covers and gray and black striped pants.
This pirate will scare anyone into giving him their buried treasure. The Skull Pirate Top and Mask Child Costume features raggedy jacket with skeletal ribcage detail. The mask is a hard-faced skeleton with soulless eyes.


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Robotic surgery gains popularity
Patients appreciate faster recovery; surgeons report ability to see better
CORPUS CHRISTI - As the patient lay motionless on the table, her belly exposed and marked for a hysterectomy, Dr. Laura Shelton prepped for surgery.Shelton removed her plastic face shield and pulled off her sanitized surgeon's gown. She sank into a rolling chair, pushed up her long sleeves to the elbows and kicked off her tennis shoes.
For the next hour, Shelton performed the hysterectomy in a pair of pink and gray ankle socks sitting at a console 6 feetfrom the patient.
A live video feed from within the woman's abdomen illuminated Shelton's pale blue eyes as she worked a set of joysticks guiding robotic arms that cut, cauterized and sutured.
This, Shelton said, is the future of surgery.
The growing popularity of this pricey equipment — which can cost more than $2 million, according to some estimates — has sparked a debate on the merits and risks of robotic surgery.
Both local hospital systems now have surgical robots in an effort, hospital officials say, to provide minimally invasive surgery that shortens patients' hospital stays. Christus Spohn Health System bought one last year and Corpus Christi Medical Center added one in January.
Surgeons who use the robots say the technology allows patients to recover quicker because they lose less blood — less than a tablespoon, in some cases — and the incisions are smaller, sometimes less than half an inch.
"We can have them back on their feet in a week instead of six weeks," said Dr. Stan Shoemaker, an obstetrician/gynecologist who operates at Corpus Christi Medical Center. "It's a much more attractive alternative."
Advocates also say robotic surgery causes less physical strain on the surgeon and could lengthen a doctor's career in the operating room. Shoemaker said the robot also allows him to perform more challenging surgeries in a minimally invasive way.
"I'm not nearly as frightened about a tough case," Shoemaker said.
But others argue that the benefits are overstated and driven by marketing, at times by the robot's manufacturer, Intuitive Surgical Inc., which earned $1.4 billion in its last fiscal year.
One recent study suggested there was no solid scientific evidence to back claims that robotic surgery is more precise and results in less pain. The study, released in May by Johns Hopkins University School of Medicine researchers, also argued that hospitals often use Intuitive Surgical's promotional materials and fail to talk about robotic surgery risks, including claims that such surgeries can take more time, causing patients to remain under anesthesia longer, and that they are more costly.
There remains a healthy debate about the merits of traditional surgery versus the robotic procedure, said Dr. Benjamin Lowentritt, a urologist in Baltimore who solely offers robotic surgery.
"I don't think it does anyone any good to declare it as a cure-all and the perfect treatment," he said. "I would not advocate (open surgery) in my practice, but at the same time, I don't fault anyone for making that choice."
Still, Lowentritt said, it's difficult for any hospital to opt against offering robotic surgery because of the strong patient demand.
"I wouldn't want to go to a hospital that didn't have it for my prostate care," he said. "To be a center that provides the full complement of care to your patients, I think it is something that you should have."
Plus, he said, robotic surgery acts as a good recruiting tool for new surgeons.
"As time goes on, hospitals and communities that don't have them will more and more have difficulty attracting newer and recently trained physicians," he said.n n nFor the past 1½ years, Debra Cantu, 34, struggled with near-constant pelvic pain and an overactive bladder. She popped pain relievers at least three times a week and ran to the bathroom once an hour. She woke frequently at night to use the restroom.
Shelton diagnosed her with uterine fibroids, which are noncancerous tumors, and possibly endometriosis, a painful condition where tissue typically lining the uterus grows outside the uterus, becomes inflamed and eventually develops scar tissue and adhesions, which bind organs together and causes pelvic pain, according to the Mayo Clinic.
Shelton recommended giving Cantu a partial hysterectomy using Christus Spohn Health System's da Vinci robot.
The robots are controlled solely by the surgeon, who sits at a nearby console and views the surgery through a viewfinder, where the images are magnified 10 times and appear in 3D.
Robotic instruments, which look like miniature forceps, are inserted through tubes in the patient's body. The surgeon uses joysticks to direct them to pinch, cut and sew.
Using a pedal that looks like a car accelerator, the surgeon can move around a small, lighted camera, usually inserted through a tube in the patient's belly button, to peek around organs and zoom in on blood vessels. The surgeon uses another pedal to deliver bursts of electricity that cauterize, or burn, tissue and blood vessels to seal them and stop the bleeding.
As Shelton worked at the console Wednesday – shoeless, she said, so she could better feel the pedals – she navigated the instruments past organs and blood vessels that filled the flat-screen televisions on each side of the operating room.
Shelton pointed to scar tissue and adhesions that marred the inside of Cantu's pelvis and decided she had to do a complete hysterectomy. It was the only option, she said, that could relieve Cantu of her pain, even though it would force the mother of two into early menopause.
It was an option they had discussed in a pre-operative appointment, but once Shelton saw in excruciating detail the extent of the scarring from Cantu's endometriosis, she said she realized the problem was worse than expected. Cantu's ovaries had adhered to her abdominal wall and scar tissue was tucked underneath her uterus, a typically hard-to-reach area for a surgeon.
Shelton said she wouldn't have been able to see such detail with traditional surgery, which likely would have been more challenging.
"The visualization is key," she said. "I could see exactly where the adhesions were, exactly where to cut."
Lowentritt, who said he was skeptical at first of what he thought would be a gimmicky new technology, said the visualization provided by robotic surgery changed his mind.
"I feel like it has made me a much better surgeon because I could see for the first time in ways I couldn't with open surgery," he said.n n nWhile hospitals nationwide offer robotic surgery for a variety of procedures, from heart surgery to gastric bypass, the local hospitals so far only offer it for gynecological and urologic surgeries, such as hysterectomies and prostate removals.
All surgeons working with the robot must be trained.
Christus Spohn Health System bought its robot for urologists at Spohn Hospital Shoreline, but officials moved the robot in March to Spohn Hospital South so it could get more use, spokeswoman Katy Kiser said.
The hospital system has used it 115 times, and five gynecologist surgeons now operate on it, da Vinci representative Michael Isaac said. Kiser said the hospital system has plans to train more surgeons on the robot and expand its surgical offerings, but no plans to buy additional robots.
Corpus Christi Medical Center bought a newer version of the robot in January and surgeons there since have performed 150 gynecologic and urologic procedures, hospital spokeswoman Lisa Robertson said. Twelve hospital system surgeons are trained on the robot, she said.
Dr. Joseph Wagner, director of robotic surgery at Hartford Hospital in Connecticut, said he considers a robot thoroughly used at 500 cases a year.
He suggests hospitals consider expansion if their robots hit 350 to 400 annual operations, well above the usage level at Corpus Christi hospitals.
Kris Muller, spokeswoman for Corpus Christi Medical Center's parent company HCA, said robotic surgery does not cost patients more than traditional surgery. Some insurance policies cover the full cost, others do not, Shelton said.
n n n
While the debate continues about the cost of the technology and long-term benefits for patients, there seems to be little argument that robotic surgery is better for the surgeon.
Surgeons say robotic surgery leaves them less fatigued, allows them to see better within the body and gives them the ability more easily to suture, or sew tissue, than they could with traditional laparoscopic surgery, a type of minimally invasive surgery in which surgeons work at the bedside using long, slender, chopstick-like instruments inserted through small incisions in a patient's body.
Dr. Alan Nesbit, a urologist who operates at Corpus Christi Medical Center, said the robot is easier on his body than traditional laparoscopic procedures, which left him exhausted.
His knees, hips and back ached after standing for five or six hours at a patient's bedside, his arms positioned in an awkward manner over the patient's body.
"No matter how strong you are, it's a very physical surgery," he said.
Shoemaker said, without the robot, his persistent back pain and arthritis likely would have forced him to take a break from surgery. Robotic surgery allows him to rest his back by sitting in a cushy chair at a console, instead of standing for hours at a patient's bedside.
"It's extended my surgical career by 10 years," he said.
At Cantu's hysterectomy on Wednesday, Shelton chatted easily while she performed complicated maneuvers within Cantu's pelvis. As she flicked her wrists at the joysticks, the robotic instruments pushed a tiny, thin needle with barbed-wire-like thread in and out of the tissue. Shelton said she was operating within a space the size of a pingpong ball.
This is the kind of technique that, if done in a traditional laparoscopic way, would have been more difficult and physically draining, Shelton said.
"I feel like I'm going to go exercise now and I wouldn't have wanted to go exercise had I done it laparoscopically," she said after the surgery. "I would've been too sore. I would've said, 'I've done my exercise for the day.'"
n n n
Experts say robotic surgery is likely to expand in coming years, particularly as the technology improves. Surgeons say they expect the devices will get smaller and eventually provide tactile feedback, giving surgeons back the sense of feel that they traded for the magnified, high-definition vision that came with robotic surgery.
More patients already are opting for robotic surgery, with an estimated 85 percent of men now having their prostates removed robotically, Wagner said.
Nesbit said men with prostate cancer are more likely now to opt for prostate removal via robotic surgery than to have radiation, he said.
"They can be out of the hospital in a day or two, rather than undergo eight weeks of radiation," he said.
And, because robotic surgery is offered in Corpus Christi, these men are more willing to stay here for surgery, rather than travel to San Antonio or Houston for the procedure, Nesbit said.
Martha Hoops, 39, who struggled with hormonal mood swings and pelvic pain after her Caesarean-section scar fused to her uterus, said she put off surgery until she heard about robotic surgery from a nurse friend.
She said she specifically sought the treatment at Corpus Christi Medical Center.
While patients seem less leery of robotic surgery because of its claims of smaller incisions, quicker recovery times and less blood loss, surgeons must be careful not to overplay its benefits, particularly the long-term benefits, experts said.
For example, research shows that men who have their prostates removed often struggle with post-surgical incontinence and impotence regardless if they receive traditional or robotic surgery, Lowentritt said.
Wagner urges patients not to be believe all the hype they hear and read about robotic surgery.
"The robot is a bit better than open surgery but it's not night and day," he said.
n n nHowever, patients who have received the surgery tend to describe their recovery in superlatives.
Cantu was able to walk in her hospital room unassisted just hours after her hysterectomy. She brushed her teeth. Nearly a day after her surgery, she had taken pain medication just twice.
Lying in her hospital bed Thursday morning, Cantu said she didn't realize she had four incisions in her abdomen.
"I thought I only had one cut, literally," Cantu told Shelton when she came in to check on her the morning after surgery. "When I looked down I only saw one cut, and then the nurse comes in and says, 'No you have four,' and I'm like, 'Where?'"
Hoops had her hysterectomy on a Friday in March. She was back at work the following Wednesday.
She said when she awoke from the surgery, she felt in a way she hadn't for a long time.
"I was a different person," she said.
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StartUpHire is the place to find Implementation-Manager jobs in and near . Review the list below of Implementation-Manager jobs. These Implementation-Manager jobs represent some of the most rewarding careers available. You can refine your job search for Implementation-Manager jobs in by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options. Don't see the employment opportunity you're looking for? Check back soon for more Implementation-Manager jobs in , or sign up for an email alert (link in upper left) to receive periodic updates on new Implementation-Manager jobs in , .
Our clients include some well-known names in film, tv and online video. You will set up and deploy measurable video, programmatic, mobile and social campaigns in advanced platforms. You will be a day-to-day campaign manager and optimize campaigns which pi7/6/2015 New York, NY Save This Job
Overview: The Sr. Implementation Manager is responsible for all aspects of new parcel and fulfillment client on-boarding, solution enhancements for existing clients, and client satisfaction in general. Project efforts extend from an internal sales hand off meeting though6/15/2015 Austin, TX Save This Job
An Implementation Manager works directly with clients during implementations to define and configure services on the Empyrean platform. They work closely with the assigned ongoing teams to manage day-to-day services during the implementation phases. Our Implementation Managers5/27/2015 Houston, TX Save This Job
Job description We are growing and are seeking an exceptional Sr. Customer Success & Implementation Manager to join our team. This individual will play an instrumental part in the overall success of the Company in our mission to ensure the highest level of customer success. This5/31/2015 Austin, TX Save This Job
Job Location: Chicago, IL Reports to: Director, Professional Services Description As a highly visible and customer-facing position, the Implementation Manager works with an exceptional professional services organization, including project managers, product owners, process5/4/2015 Chicago, IL Save This Job
WiredBenefits is a pioneer in the field of prepaid healthcare, offering a system of prepaid cards and back-end solutions to the employee benefits, retail, and healthcare sectors. WiredBenefits' products operate at the intersection of healthcare delivery, consumer choice and the5/23/2015 San Mateo, CA Save This Job
Position Overview: The Implementation Manager will oversee and direct the deployment of new products, services or projects related to new customer software implementation. Essential Functions: -Work set hours to meet BestTransport?s clients? needs and expectations.5/19/2015 Columbus, OH Save This Job
Silverlink Communications, located in Burlington, MA, is a fast-growing provider of integrated communications solutions that significantly increase revenue, reduce costs, improve clinical outcomes and increase client/member satisfaction for healthcare enterprises. The company?s7/6/2015 Burlington, MA Save This Job
The Position Wellcentive is looking for experienced, client facing Implementation Managers in Atlanta, GA, Dallas, TX or New York, NY. As health systems are leveraging more and more disparate technologies to improve their clinical and financial outcomes; they are turning to5/18/2015 Alpharetta, GA Save This Job
As a Technical Account Manager at BloomReach, you will ensure success of our premier customers by providing expertise in technology, implementation and functionality of BloomReach products.5/1/2015 Mountain View, CA Save This Job
Are you a marketing content strategy guru Do you live and breathe email marketing HubSpot is seeking a Channel Campaigns Marketing Manager to join a fast-growing team helping to redefine the world of marketing.6/1/2015 Cambridge, MA Save This Job
The Manager, Global Compensation and Rewards will leverage the large data resource behind Quantcast's greatest asset, our talented employees, to ensure that we continually foster a high performance, open culture. We are evolving our compensation pro6/29/2015 San Francisco, CA Save This Job
Quantcast is seeking a Manager, Media Operations to ensure successful delivery of all display advertising campaign goals in conjunction with the Client Services and Sales teams. This role is responsible for a team of Campaign Managers that work on both th6/14/2015 New York, NY Save This Job
The Client Services Manager will report directly to the Director of Client Services and serve a critical role in helping manage all client-related services and interactions.6/27/2015 New York, NY Save This Job
Silver Peak Systems is seeking a Field and Channel Marketing Manager to help enable its award winning channel. This position is a critical addition to the Silver Peak Marketing organization. This individual will be responsible for assisting wi5/20/2015 Santa Clara, CA Save This Job
Are you ready to be a part of a rapid growth startup If so, read on. AppFolio, an award winning web-based Software-as-a-Service (SaaS) company is hiring now. The Inside Sales Manager is responsible for developing, motivating and guiding the6/2/2015 Dallas, TX Save This Job
Are you ready to be a part of a rapid growth startup If so, read on. AppFolio, an award winning web-based Software-as-a-Service (SaaS) company is hiring now. The Inside Sales Manager is responsible for developing, motivating and guiding the6/2/2015 Santa Barbara, CA Save This Job
Position Summary: This new management position reports to the COO to execute time and cost-effective field implementation projects. Primary responsibilities include: Leadership and supervision of the field implementation teams to ensure high-quality and efficient thermal system5/19/2015 Gardner, MA Save This Job
RESONSIBILITIES Responsibilities of this position include owning and cultivating client relationships for assigned clients during the implementation phase and throughout the ongoing relationship. This candidate must have excellent communication and client management skills in7/6/2015 Burlington, MA Save This Job
Description The Implementation Manager oversees and directs the deployment of new products, services or projects for the organization to ensure successful execution. This role is a customer facing role that acts as an extension of Client Services and Account Executives. Minimum6/3/2015 Tampa, FL Save This Job


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" The Ballot Van is a modified Pony in Grand Theft Auto: Liberty City Stories. The vans are...
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text:
The Federal Trade Commission challenged the merger
The Supreme Court legalized gay marriage in the U.S.
Join the NASDAQ Community today and get free, instant access to portfolios, stock ratings, real-time alerts, and more!
The iShares Core S&P 500 ETF (NYSEArca:IVV) is now the
fourth-largest U.S.-listed ETF after net inflows of $212 million in
May-and positive market action-pushed it two spots up in the
rankings in one month.
The fund, which now has $42.55 billion in total assets, ended
April with $41.36 billion, and basically switched places with the
iShares MSCI Emerging Markets Index Fund (NYSEArca:EEM). But IVV
also surpassed the iShares MSCI EAFE Index Fund (NYSEArca:EFA),
which ended both May and April in the No. 5 spot.
What makes this rising trajectory noteworthy is the fact the
13-year-old fund hadn't been a regular member of the top-asset
gatherers list for many years. But it seems to be gathering assets
faster since iShares rebranded it a "Core" fund last October, and
slashed its price tag some 22 percent to 0.07 percent. That's $7
per $10,000 invested.
Indeed, since the beginning of October, investors have poured a
net of nearly $6 billion into this fund-$2 billion of it came in
that very first month alone.
That's particularly impressive considering that IVV swims in one
of the most popular pockets of the ETF industry, namely the U.S.
large-cap space, where funds like the SPDR S&P 500 ETF
(NYSEArca:SPY)-the long-standing No. 1 ETF in terms of
assets-compete. SPY has gathered only a net of $3.5 billion in that
same October-to-date period.
The Skinny On 'Core'
It seems iShares' decision to launch a series of what it calls
"Core" funds, and rebrand some existing strategies to fit under
that umbrella of now-10
, is paying off.
Year-to-date, this family of ETFs that include the likes of the
iShares Core Total U.S. Bond Market ETF (NYSEArca:AGG), and the
iShares Core MSCI Emerging Markets ETF (NYSEArca:IEMG), has
attracted a combined net of some $5.75 billion in assets, according
to data compiled by IndexUniverse.
In fact, only one of the 10 ETFs-the iShares Core Long-Term U.S.
Bond ETF (NYSEArca:ILTB)-has bled assets this year, to the tune of
$136 million. And that's not surprising, given investors' ongoing
aversion to long-dated U.S. government debt in the current
environment of already-low rates and nagging concern that the long
end of the bond market is in for a nasty correction when rates do
start to normalize.
Until the unveiling of the Core brand, iShares had been watching
lower-cost competitors such as Vanguard, and even Charles Schwab,
slowly and consistently encroach on its years-long market share
leadership, and it struggled to defend its first-to-market
advantage in many market segments due to higher expense ratios on
many ETFs.
The idea to roll out this Core ETF brand initiative in an effort
to compete on cost was timely, as investors have grown more aware
of the importance of ETF fees.
The move resulted in price cuts of as much as 65 percent on some
of its existing ETFs last fall, and the launch of
similar-but-cheaper funds-like the developing-markets fund IEMG-in
an effort to revitalize its footprint in the market.
IVV is now closing in on the SPDR Gold Trust (NYSEArca:GLD)-the
third-largest ETF, with $45.4 billion. GLD has been consistently
bleeding assets this year. SPY and the Vanguard FTSE Emerging
Markets ETF (NYSEArca:VWO) currently rank Nos. 1 and 2 on
IndexUniverse's latest "ETF Giants" table.
Permalink | 'copy; Copyright 2009 IndexUniverse LLC. All rights
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2013 IndexUniverse LLC
. All Rights Reserved.
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text: White Sox Rookie Pumped and Ready to Face Tribe From SunTimes.com Sep 26, 2012 Share Tweet Next ARTICLE » Use your ← → (arrow) keys to browse more stories Brian Kersey/Getty Images 13 Reads 0 Comments The White Sox are down to an eight-game season. In Game 1, rookie left-hander Hector Santiago will take the ball. Continue Reading on SunTimes.com »


text: Skin, Eyes, and the SunAlong with warmth, the sun also produces light and an invisible ultraviolet (UV) radiation. UV radiation can cause sunburn, wrinkles, sunspots, cataracts, and skin cancer, and probably contributes to macular degeneration. The tan was once a symbol of health, but now has been shown to be the result of exposure to UV radiation.You can protect yourself from skin cancer and other sun damage by using sunscreen, covering up, and wearing sunglasses that block UV rays.Some UV radiation, however, is important for the body to make vitamin D, which helps you absorb calcium and phosphorus. The World Health Organization says that five to 15 minutes of sun on your hands, face, and arms, two to three times a week during the summer, is adequate for this.Use sunscreenChoose a sunscreen that protects against both UVA and UVB rays. Look for the words "broad-spectrum sunscreen" on the label. Experts consider sun exposure to be the most preventable risk factor for all skin cancers, so take sun protection seriously.Wear sunscreen with a sun protection factor (SPF) of at least 30 whenever you go outdoors. It's best to apply sunscreen about 20 to 30 minutes before going outside so your skin has time to absorb it. You should reapply sunscreen often, at least every two hours, and especially after exercising or swimming. Remember that even on cloudy days, you are exposed to UV rays; so don't skip the sunscreen.According to the American Academy of Dermatology, most people don't use enough sunscreen. The average-sized person needs at least one ounce—about two tablespoons—of sunscreen to cover his or her body.Protect your eyesAccording to the American Academy of Ophthalmology, the UV radiation in sunlight can also damage eye tissue.UV damage to the eye may cause cataracts and macular degeneration, which can lead to blindness. Risk for damage is higher in environments where a large quantity of UV radiation is reflected, such as in snow or on water.Experts recommend sunglasses that provide 99 to 100 percent protection from UVA and UVB rays. Be aware that darker-colored lenses don't always protect your eyes better—a special, protective coating makes the difference. To prevent sunlight from slipping in around the edges, wear close-fitting sunglasses that wrap around.Studies show the sun exposure is greater when it's reflected by water, snow, or concrete, so use sunscreen and wear sunglasses even while sitting under an umbrella.Cover upHere are more guidelines to protect your skin:Wear a hat with a brim that's at least four inches wide. Baseball caps don't protect your ears or neck.Wear protective clothing that covers your neck, arms, and legs. Fabrics with a tight weave help block sunlight.Limit the amount of time you spend in the sun between 10 a.m. and 4 p.m. Health Encyclopedia A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Search Health Library


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The 27-year-old from Glasgow carded 10 birdies, which included holing her third shot at the 14th after a penalty drop from behind a tree, at Golfclub Worthsee.
Her score moved her to 24 under par with an aggregate of 259, one better than Frenchwoman Gwladys Nocera's score at the 2008 Goteborg Masters.
Walker now heads into today's final round with a six-stroke lead over China's Yu Yang Zhang and England's Charley Hull.
A final round of 66 would see her set a new Ladies European Tour record for the lowest 72-hole total, at 30-under-par.
"I feel really comfortable with my game," said the Scot.
"I would love to win and I've just got to try to do the same again and keep playing the way I'm playing."
Hull fired eight birdies for her second 64 of the tournament and is also in contention for her second LET victory this season.
Six birdies and one bogey in a round of 67 ensured 22-year-old Zhang remains in the mix for her first LET trophy.
She said: "I think I will be playing with two long hitters so I will stick to my game plan and just try to make birdies and focus on my shots."
Two strokes further behind at 16-under, French duo Celine Herbin and the 2012 tournament champion Anne-Lise Caudal lie in a tie for fourth spot.


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Peter Lenz is attended to by emergency personnel after his crash at Indianapolis Motor Speedway. The 13-year-old died as a result of the injuries he suffered during the warm-up of a race.
- Filed Under
Tragedy clouded the MotoGP race Sunday after a 13-year-old rider was killed in an accident at Indianapolis Motor Speedway.
Peter Lenz, Vancouver, Wash., died after suffering injuries in a crash before the start of the U.S. Grand Prix Riders Union race. The accident occurred sometime after 10:20 a.m. during a warm-up lap, but officials did not immediately confirm the fatality pending notification of Lenz's mother, IMS spokesman Eric Powell said.
Stewart Aitken-Cade, chief steward of USGPRU, said later in the afternoon that Lenz died after falling and being hit by another rider. The other ...


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The present invention describes compounds useful for the inhibition of Farnesyl Protein Transferase. This invention also discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with FPT.
5. A method of inhibiting FPT comprising administering to a patient in need of such treatment a compound of
6. A pharmaceutical composition comprising a compound of
7. A method of inhibiting the growth of pancreatic tumor cells, lung tumor cells, myeloid leukemia tumor cells, thyroid follicular tumor cells, myelodysplastic tumor cells, epidermal carcinoma tumor cells, bladder tumor cells or colon tumor cells, in a patient in need of such treatment by inhibition of farnesyl protein transferase, comprising, administering to said patient, an effective tumor inhibiting amount of a compound of
This application claims the benefit of U.S. Provisional Application Ser. No. 60/253,971 filed Nov. 29, 2000.
WO 95/10514, WO 95/10515, WO 95/10516, published Apr. 20, 1995, WO 97/23478, published Jul. 3, 1997, and WO 98/57949, published Dec. 32, 1998, disclose tricyclic compounds useful for inhibiting farnesyl protein transferase.
In view of the current interest in inhibitors of farnesyl protein transferase, a welcome contribution to the art would be compounds useful for the inhibition of farnesyl protein transferase. Such a contribution is provided by this invention.
This invention provides compounds selected from the group consisting of:
In another embodiment, this invention provides a process for producing intermediate compound (4)
(a) dissolving compound (3)
in a solvent mixture comprising a suitable aprotic solvent (such as, for example, CH2Cl2, CHCl3 or benzene) and dimethylacetamide, said aprotic solvent to dimethylacetamide in a molar ratio in a range of about 1-10:1.0. Preferably said aprotic solvent to dimethylacetamide is in a molar ratio of 3.5:1.0;
(b) cooling the reaction mixture to a temperature of between about (−)10� C. and about (+)10� C.;
(c) adding about 10 to about 40 molar equivalents of thionyl bromide (i.e., SOBr2; Preferably the SOBr2 is freshly prepared (i.e., prepared and used within 72 hours) Still more preferably, the SOBr2 is prepared and used within 48 hours.
(d) stirring the reaction mixture at a temperature between about (−)10� C. and about (+)40� C., (in general the reaction is stirred for about 4 to about 10 hours, preferably about 4 hours);
(e) basifying the reaction mixture with an appropriate aqueous alkaline solution such as, a solution of NaOH, NaHCO3, NH4OH, and the like. Preferably the aqueous alkaline solution concentration is 1N; and
(f) extracting the resulting solution with a suitable organic solvent such as, for example, CH2Cl2, ethyl acetate, and the like.
In general, intermediate compound (4) obtained from the above process, is purified using techniques well known in the art, (e.g., flash silica gel column chromatography, HPLC, and the like).
The compounds of this invention are potent Farnesyl Protein Transferase inhibitors having good pharmacokinetic stability.
The compounds of this invention: (i) potently inhibit farnesyl protein transferase, but not geranylgeranyl protein transferase I, in vitro; (ii) block the phenotypic change induced by a form of transforming Ras which is a farnesyl acceptor but not by a form of transforming Ras engineered to be a geranylgeranyl acceptor; (iii) block intracellular processing of Ras which is a farnesyl acceptor but not of Ras engineered to be a geranylgeranyl acceptor; and (iv) block abnormal cell growth in culture induced by transforming Ras.
The compounds of this invention inhibit farnesyl protein transferase and the farnesylation of the oncogene protein Ras. Thus, this invention further provides a method of inhibiting farnesyl protein transferase, (e.g., ras farnesyl protein transferase) in mammals, especially humans, by the administration of an effective amount (e.g. a therapeutically effective amount) of the tricyclic compounds listed below. The administration of the compounds of this invention to patients, to inhibit farnesyl protein transferase, is useful in the treatment of the cancers described below.
This invention provides a method for inhibiting or treating the abnormal growth of cells, including transformed cells, by administering an effective amount (e.g. a therapeutically effective amount) of a compound of this invention. Abnormal growth of cells refers to cell growth independent of normal regulatory mechanisms (e.g., loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors) expressing an activated Ras oncogene; (2) tumor cells in which the Ras protein is activated as a result of oncogenic mutation in another gene; and (3) benign and malignant cells of other proliferative diseases in which aberrant Ras activation occurs.
This invention also provides a method for inhibiting or treating tumor growth by administering an effective amount (e.g., a therapeutically effective amount) of the tricyclic compounds, described herein, to a mammal (e.g., a human) in need of such treatment. In particular, this invention provides a method for inhibiting or treating the growth of tumors expressing an activated Ras oncogene by the administration of an effective amount (e.g. a therapeutically effective amount) of the below described compounds.
Examples of tumors which may be inhibited or treated include, but are not limited to, lung cancer (e.g., lung adenocarcinoma), pancreatic cancers (e.g., pancreatic carcinoma such as, for example, exocrine pancreatic carcinoma), colon cancers (e.g., colorectal carcinomas, such as, for example, colon adenocarcinoma and colon adenoma), myeloid leukemias (for example, acute myelogenous leukemia (AML)), thyroid follicular cancer, myelodysplastic syndrome (MDS), bladder carcinoma, epidermal carcinoma, melanoma, breast cancer and prostate cancer.
It is believed that this invention also provides a method for inhibiting or treating proliferative diseases, both benign and malignant, wherein Ras proteins are aberrantly activated as a result of oncogenic mutation in other genes—i.e., the Ras gene itself is not activated by mutation to an oncogenic form—with said inhibition or treatment being accomplished by the administration of an effective amount (e.g. a therapeutically effective amount) of the tricyclic compounds described herein, to a mammal (e.g., a human) in need of such treatment. For example, the benign proliferative disorder neurofibromatosis, or tumors in which Ras is activated due to mutation or overexpression of tyrosine kinase oncogenes (e.g., neu, src, abl, lck, and fyn), may be inhibited or treated by the tricyclic compounds described herein.
The tricyclic compounds useful in the methods of this invention inhibit or treat the abnormal growth of cells. Without wishing to be bound by theory, it is believed that these compounds may function through the inhibition of G-protein function, such as Ras p21, by blocking G-protein isoprenylation, thus making them useful in the treatment of proliferative diseases such as tumor growth and cancer. Without wishing to be bound by theory, it is believed that these compounds inhibit ras farnesyl protein transferase, and thus show antiproliferative activity against ras transformed cells.
As used herein, the following terms are used as defined below unless otherwise indicated:
MH+-represents the molecular ion plus hydrogen of the molecule in the mass spectrum;
BOC-represents tert-butyloxycarbonyl;
CH2Cl2-represents dichloromethane;
CIMS-represents chemical ionization mass spectrum;
DEC-represents EDCl which represents 1-(3-dimethyl-aminopropyl)-3-ethylcarbodiimide hydrochloride;
DMF-represents N,N-dimethylformamide;
Et-represents ethyl;
EtOAc-represents ethyl acetate;
EtOH-represents ethanol;
HOBT-represents 1-hydroxybenzotriazole hydrate;
IPA-represents isopropanol;
iPrOH-represents isopropanol;
Me-represents methyl;
MeOH-represents methanol;
MS-represents mass spectroscopy;
FAB-represents FABMS which represents fast atom bombardment mass spectroscopy;
HRMS-represents high resolution mass spectroscopy;
NMM-represents N-methylmorpholine;
Et3N-represents TEA which represents triethylamine;
t-BUTYL-represents —C—(CH3)3;
THF-represents tetrahydrofuran;
FPT-represents Farnesyl Protein Transferase;
Certain compounds of the invention may exist in different isomeric (e.g., enantiomers, diastereoisomers, atropisomers) forms. The invention contemplates all such isomers both in pure form and in admixture, including racemic mixtures. Enol forms are also included.
Certain tricyclic compounds will be acidic in nature, e.g. those compounds which possess a carboxyl or phenolic hydroxyl group. These compounds may form pharmaceutically acceptable salts. Examples of such salts may include sodium, potassium, calcium, aluminum, gold and silver salts. Also contemplated are salts formed with pharmaceutically acceptable amines such as ammonia, alkyl amines, hydroxyalkylamines, N-methylglucamine and the like.
Certain basic tricyclic compounds also form pharmaceutically acceptable salts, e.g., acid addition salts. For example, the pyrido-nitrogen atoms may form salts with strong acid, while compounds having basic substituents such as amino groups also form salts with weaker acids. Examples of suitable acids for salt formation are hydrochloric, sulfuric, phosphoric, acetic, citric, oxalic, malonic, salicylic, malic, fumaric, succinic, ascorbic, maleic, methanesulfonic and other mineral and carboxylic acids well known to those in the art. The salts are prepared by contacting the free base form with a sufficient amount of the desired acid to produce a salt in the conventional manner. The free base forms may be regenerated by treating the salt with a suitable dilute aqueous base solution such as dilute aqueous NaOH, potassium carbonate, ammonia and sodium bicarbonate. The free base forms differ from their respective salt forms somewhat in certain physical properties, such as solubility in polar solvents, but the acid and base salts are otherwise equivalent to their respective free base forms for purposes of the invention.
All such acid and base salts are intended to be pharmaceutically acceptable salts within the scope of the invention and all acid and base salts are considered equivalent to the free forms of the corresponding compounds for purposes of the invention.
The compounds of this invention can exist in unsolvated as well as solvated forms, including hydrated forms, e.g., hemi-hydrate. In general, the solvated forms, with pharmaceutically acceptable solvents such as water, ethanol and the like are equivalent to the unsolvated forms for purposes of the invention.
The following processes may be employed to produce compounds of the invention.
Step 1
Compound (1) (see Preparative Example 9 Step D of US Patent Case No. IN0549), 20 g (0.05 mol) was dissolved in 1 L of dry THF. This solution was added to a solution of Grignard reagent (80 mL, 1.56M in THF (250 mL), 0.125 mol, 2.5 equiv.) cooled to −40� C. The reaction mixture was agitated for 0.5 h and then quenched with NH4Cl (100 mL). THF was removed by distillation (1200 mL) and 500 mL of CH2Cl2 were added and the pH adjusted to 5 with 10% HCl. The aqueous phase was extracted with CH2Cl2 (250 mL) and the organic phase was separated from the aqueous phase. Combined organic phases were washed with sat. NaHCO3 and then dried over anhydrous Na2SO4 and passed through a short pad of celite. Acetonitrile 300 mL was then added and CH2Cl2 was distilled until only 300 mL remained. Crytstals precipitated out and were collected and dried to give 15.9 g (64%) of the target azaketone; MH+=501.
Step 2
To a solution of compound (3) (5.0 g, 9.97 mmol) from Step 1 above, in CH2Cl2 (25 mL) was added dimethylacetamide (9.5 g, 109 mmol, 10 mL) and the reaction mixture was brought to 0� C. Thionyl bromide (35 mL freshly prepared from NaBr and SOCl2) was slowly added to the reaction mixture. The reaction was stirred for 4 h. The reaction mixture was then partitioned between saturated NaHCO3 and CH2Cl2. The organic phase was dried with Na2SO4 and then purified by flash column chromatography (silica gel, 1% MeOH—NH3—CH2Cl2) to give the product as a solid (0.82 g, 17% yield); mp=73-75; MS (FAB) m/z 483 (MH+).
Step 3
To a solution of compound (4) (3.51 g, 7.3 mmol) from Step 2 above, in toluene (70 mL) was slowly added Et3N (2.5 g, 25 mmol, 3.6 mL) and the reaction mixture was brought to reflux. Ethyl chloroformate (3.96 g, 36.5 mmol, 3.5 mL) was added to the reaction mixture and refluxing continued for 16 h. The reaction mixture was partitioned between EtOAc and 1N NaOH. The organic phase was dried with MgSO4 and then purified by flash column chromatography (silica gel, 20% EtOAc-hexane) to give the product as a solid (3.70 g, 94% yield); mp=63-64; MS (FAB) m/z 541 (MH+).
Step 4
To 80 mL of Conc. HCl was added Compound (5) (3.65 g, 6.8 mmol) from Step 3 above. The reaction mixture was refluxed for 16 h. It was then cooled, poured into ice and basified to pH=10 with aqueous 50% NaOH. The aqueous phase was extracted with CH2Cl2. Concentration of the organic phase afforded 2.02 g of Compound (6) mp=88-89� C.; MS m/z (rel intens) 469 (MH+).
Step 5
Separation on HPLC using a Chiralpack AD column and 20% isopropanol-80% hexane-0.2% diethylamine as eluent gave enantiomeric amines 7 and 8.
Compound (7): mp=82-83; [α]D 22=−116.8� (7.64 mg/2 mL CHCl3); MS (FAB) m/z 469 (MH+).
Compound (8): mp=88-89; [α]D 22=+150.0� (6.02 mg/2 mL CHCl3); MS (FAB) m/z 469 (MH+).
Step 1
A mixture of Compound (7) (0.74 g, 1.58 mmol) from Preparative Example 1, Step 5, piperidylacetic acid N-BOC (0.72 g, 3.16 mmol), HOBT (0.27 g, 2.05 mmol), DEC (0.39 g, 2.05 mmol) and dry DMF (10 mL) was stirred at 25� C. for 16 hrs. The mixture was concentrated in vacuo, diluted with CH2Cl2 and washed with saturated NaHCO3 (aqueous) and 10% NaH2PO4 (aqueous). The organic phase was dried over anhydrous MgSO4 and concentrated in vacuo to provide to give the (−) isomer, Compound (9) as a solid (1.19 g, 100% yield); mp=73-74; MS (FAB) m/z 694.2 (MH+).
Step 2
A solution of Compound (9) (1.06 g, crude residue from Step 1 above), anhydrous dichloromethane (15 mL) and trifluoroacetic acid (4 mL) was stirred at 0� C. for 3 h. The solution was cooled in ice-water and treated slowly with 50% aqueous sodium hydroxide until basic. The mixture was poured into dichloromethane and washed with water. The organic phase was dried over anhydrous MgSO4 and concentrated in vacuo to give Compound (10) (0.82 g, 100% yield); mp=94-95� C.; MS (FAB) m/z 594 (MH+).
A mixture of Compound (7) (0.2 g, 0.43 mmol) (from Preparative Example 1 Step 5), pyridylacetic acid N-oxide (0.13 g, 0.86 mmol), HOBT (0.075 g, 0.55 mmol), DEC (0.106 g, 0.55 mmol), N-methylmorpholine (0.06 mL, 0.55 mmol) and dry DMF (5 mL) was stirred at 25� C. for 16 hrs. The mixture was concentrated in vacuo, diluted with CH2Cl2 and washed with Sat. NaHCO3 (aqueous) and saturated NaH2PO4 (aqueous). The organic phase was dried over anhydrous MgSO4 and concentrated in vacuo to provide a residue which was purified by flash column chromatography (silica gel, 5% MeOH/CH2Cl2+NH4OH) to give Compound (11) as a solid (0.12 g, 73% yield). mp=137-139; [α]D 22=−70.1� (10.1 mg/2 mL CHCl3); MS (FAB) m/z 604 (MH30 ).
Compound (12) was prepared by following essentially the same procedure as Example 1, except that compound (8) of Preparative Example 1, Step 5 was used instead of compound (7). (89% yield); mp=142-143; [α]D 22=+75.2� (10.0 mg/2 mL CHCl3); MS (FAB) m/z 604 (MH+).
To Compound (7) (0.10 g, 0.21 mmol) from Preparative Example 1, Step 5, and triethylamine (0.043 g, 0.06 mL, 0.43 mmol) dissolved in anhydrous dichloromethane (5 mL) was added methanesulfonyl chloride (0.037 g, 0.03 mL, 0.32 mmol). After stirring at room temperature overnight, the solution was diluted with dichloromethane (100 mL), washed with saturated NaHCO3 and dried over anhydrous magnesium sulfate. Filtration and concentration in vacuo afforded Compound (13) (0.10 g, 89%, mp=84-85� C.); [α]D 22=−73.1� (7 mg/2 mL CHCl3); MS (FAB) m/z 547 (MH+).
Compound (14) was prepared by following essentially the same procedure as Example 3, except that compound (8) of Preparative Example 1, Step 5 was used instead of compound (7); (99% yield); mp=91-92; [α]D 22=+95.0� (10.0 mg/2 mL CHCl3); MS (FAB) m/z 547 (MH+).
To a solution of Compound (7) of Preparative Example 1 step 5 (0.78 g, 1.31 mmol) in anhydrous dichloromethane (20 mL) was added trimethylsilylisocyanate (1.21 g, 1.42 mL, 10.51 mmol). After stirring at 25� C. for 48 h the solution was poured into dichloromethane and washed with saturated aqueous sodium bicarbonate and brine. The organic phase was dried over anhydrous MgSO4 and concentrated in vacuo to give an off-white solid. Further purification by flash column chromatography (silica gel) using 5% methanol-dichloromethane with ammonium hydroxide afforded Compound (15) as a white solid (0.56 g, 67% yield). Recrystallization from acetone provided an analytical sample; mp=146-147� C.; [α]D 25=−68.8� (8.2 mg/2 mL, CHCl3); MS (FAB) m/z 637 (MH+).
Compound (16) was prepared by following essentially the same procedure as Example 5, except that compound (8) of Preparative Example 1, Step 5 was used instead of compound (7). (74% yield); mp=142-143; [α]D 22=+78.3� (11.8 mg/2 mL CHCl3); MS (FAB) m/z 637 (MH+).
1. In Vitro Enzyme Assay:
Inhibition of farnesyl protein transferase.Farnesyl protein transferase (FPT) was partially purified from rat brain by ammonium sulfate fractionation followed by Q-Sepharose (Pharmacia, Inc.) anion exchange chromatography essentially as described by Yokoyama et al (Yokoyama, K., et al., (1991). Implications for protein prenylation specificity, Proc. Natl. Acad. Sci USA 88: 5302-5306, the disclosure of which is incorporated herein by reference thereto). Human farnesyl protein transferase was also expressed in E. coli, using cDNA clones encoding both the a and b subunits. The methods used were similar to those published (Omer, C. et al., (1993), Characterization of recombinant human farnesyl protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases, Biochemistry 32:5167-5176). Human farnesyl protein transferase was partially-purified from the soluble protein fraction of E. coli as described above. The tricyclic farnesyl protein transferase inhibitors disclosed herein inhibited both human and rat enzyme with similar potencies. Two forms of val12-Ha-Ras protein were prepared as substrates for these enzymes, differing in their carboxy terminal sequence. One form terminated in cysteine-valine-leucine-serine (Ras-CVLS) the other in cystein-valine-leucine-leucine (Ras-CVLL). Ras-CVLS is a substrate for the farnesyl protein transferase while Ras-CVLL is a substrate for geranylgeranyl protein transferase I. The cDNAs encoding these proteins were constructed so that the proteins contain an amino-terminal extension of 6 histidine residues. Both proteins were expressed in Escherichia coli and purified using metal chelate affinity chromatography. The radio labelled isoprenyl pyrophosphate substrates, [3H]farnesyl pyrophosphate and [3H] geranylgeranyl pyrophosphate, were purchased from DuPont/New England Nuclear.
Several methods for measuring farnesyl protein transferase activity have been described (Reiss et al 1990, Cell 62: 81; Schaber et al 1990, J. Biol. Chem. 265: 14701; Manne et al 1990, PNAS 87: 7541; and Barbacid & Manne 1993, U.S. Pat. No. 5,185,248). The activity was assayed by measuring the transfer of [3H]farnesyl from [3H]farnesyl pyrophosphate to Ras-CVLS using conditions similar to those described by Reiss et al. 1990 (Cell 62: 81) The reaction mixture contained 40 mM Hepes, pH 7.5; 20 mM magnesium chloride; 5 mM dithiothreitol; 0.25 μM [3H]farnesyl pyrophosphate; 10 ml Q-Sepharose-purified farnesyl protein transferase; the indicated concentration of tricyclic compound or dimethylsulfoxide (DMSO) vehicle control (5% DMSO final); and 5 mM Ras-CVLS in a total volume of 100 ml. The reaction was allowed to proceed for 30 minutes at room temperature and then stopped with 0.5 ml of 4% sodium dodecyl sulfate (SDS) followed by 0.5 ml of cold 30% TCA. Samples were allowed to sit on ice for 45 minutes and precipitated Ras protein was then collected on GF/C filter paper mats using a Brandel cell harvester. Filter mats were washed once with 6% TCA, 2% SDS and radioactivity was measured in a Wallac 1204 Betaplate BS liquid scintillation counter. Percent inhibition was calculated relative to the DMSO vehicle control.
2. Soft Agar Assay:
Anchorage-independent growth is a characteristic of tumorigenic cell lines. Human tumor cells are suspended in growth medium containing 0.3% agarose and an indicated concentration of a farnesyl transferase inhibitor. The solution is overlayed onto growth medium solidified with 0.6% agarose containing the same concentration of farnesyl transferase inhibitor as the top layer. After the top layer is solidified, plates are incubated for 10-16 days at 37� C. under 5% CO2 to allow colony outgrowth. After incubation, the colonies are stained by overlaying the agar with a solution of MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide, Thiazolyl blue) (1 mg/mL in PBS). Colonies are counted and the IC50's determined.
Results of the assay are shown in Table 1 below:
For preparing pharmaceutical compositions from the compounds described by this invention, inert, pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, dispersible granules, capsules, cachets and suppositories. The powders and tablets may be comprised of from about 5 to about 95 percent active ingredient. Suitable solid carriers are known in the art, e.g. magnesium carbonate, magnesium stearate, talc, sugar or lactose. Tablets, powders, cachets and capsules can be used as solid dosage forms suitable for oral administration. Examples of pharmaceutically acceptable carriers and methods of manufacture for various compositions may be found in A. Gennaro (ed.), Remington's Pharmaceutical Sciences, 18th Edition, (1990), Mack Publishing Co., Easton, Pa.
Liquid form preparations include solutions, suspensions and emulsions. As an example may be mentioned water or water-propylene glycol solutions for parenteral injection or addition of sweeteners and opacifiers for oral solutions, suspensions and emulsions. Liquid form preparations may also include solutions for intranasal administration.
Aerosol preparations suitable for inhalation may include solutions and solids in powder form, which may be in combination with a pharmaceutically acceptable carrier, such as an inert compressed gas, e.g. nitrogen.
Also included are solid form preparations, which are intended to be converted, shortly before use, to liquid form preparations for either oral or parenteral administration. Such liquid forms include solutions, suspensions and emulsions.
The compounds of the invention are preferably administered orally, once a day.
The compounds of the invention may also be deliverable transdermally. The transdermal compositions can take the form of creams, lotions, aerosols and/or emulsions and can be included in a transdermal patch of the matrix or reservoir type as are conventional in the art for this purpose.
Preferably, the pharmaceutical preparation is in a unit dosage form. In such form, the preparation is subdivided into suitably sized unit doses containing appropriate quantities of the active component, e.g., an effective amount to achieve the desired purpose.
The compounds of this invention are administered to a patient in need of such treatment (e.g. a mammal, such as a human being) in an effective amount, e.g. a therapeutically effective amount. The amount administered is enough to inhibit FPT.
The quantity of active compound in a unit dose of preparation may be varied or adjusted from about 0.01 mg to about 1000 mg, preferably from about 0.01 mg to about 750 mg, more preferably from about 0.01 mg to about 500 mg, and most preferably from about 0.01 mg to about 250 mg according to the particular application.
The actual dosage employed may be varied depending upon the requirements of the patient and the severity of the condition being treated. Determination of the proper dosage regimen for a particular situation is within the skill of the art. For convenience, the total daily dosage may be divided and administered in portions during the day as required.
The amount and frequency of administration of the compounds of the invention and/or the pharmaceutically acceptable salts thereof will be regulated according to the judgment of the attending clinician considering such factors as age, condition and size of the patient as well as severity of the symptoms being treated. A typical recommended daily dosage regimen for oral administration can range from about 0.04 mg/day to about 4000 mg/day, in two to four divided doses.
While the present invention has been described in conjunction with the specific embodiments set forth above, many alternatives, modifications and variations thereof will be apparent to those of ordinary skill in the art. All such alternatives, modifications and variations are intended to fall within the spirit and scope of the present invention.
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Fifa rule in Black Cats' favour
By Steve Luckings
Last Updated: 01/01/70 1:00am
The Black Cats were stunned when the Republic of Ireland midfielder's former club Celtic attempted to enforce International Football League Board rules after the 23-year-old headed for Wearside following the expiry of his contract during the summer.
They claimed Board rules state that compensation is payable for players aged 23 and under moving between English, Irish and Scottish clubs.
However, under the regulations of world governing body Fifa, the responsibility ends when a player reaches the age of 23.
Now Fifa have confirmed that they have jurisdiction and that no compensation is payable.
"We have received conformation in writing from Fifa, the international governing body of football, to advise that Fifa regulations do apply in the case of Colin Healy's transfer to Sunderland," said a club spokesman.
Sunderland had initially put the transfer on ice. However, with potential employers maintaining a watching brief, they decided to go ahead with it, confident all along that they were in the clear.
The delay meant that Healy missed the start of the season, but he has played in 19 of the club's Division One games since and has become a key member of Mick McCarthy's squad.
Fifa's ruling will come as a relief to The Black Cats, who released no fewer than 23 professionals during the summer as their dire financial situation took its toll following relegation from The Premiership.


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Originally written on NBA 24/7 365 | Last updated 12/9/12
Dahntay Jones has been a noted dunker since his days of doing celebratory pushups at Duke University.┬Ā Nearing his 32nd birthday, heŌĆÖs getting up there a bit, but make no mistake about it: DahntayŌĆÖs still got the bunnies to put somebody on a poster when given the opportunity.┬Ā Last night, second-year player Patrick Patterson found this out firsthand after throwing a regrettable swing pass intended for James Harden. The pass was intercepted and the rest is self explanatoryŌĆ" Damn, Dahntay; that was Denver Nuggets vintage!┬Ā For those who may not recall, Jones was a leading poster maker over the course of his single season with the Nuggs, racking up four POTDs in ŌĆÖ08/09.┬Ā If IŌĆÖm not mistaken, that memorable Denver squad ŌĆö which featured the likes of JR Smith, Kenyon Martin, Carmelo Anthony, and Nene ŌĆö still holds the record for most collective POTDs in a single season. Honorable mention to Alonzo Gee, who has been a monster over the past few days. Dunk rating on the Starbury Nastiness Scale: 8.5/10 2012/13 Daily Poster Stats Throwback Poster of the Day: Corey Maggette on Solomon JonesŌĆ"
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Print or e-mail your favorites and plan your perfect visit to NYC today.
Learn more about the five boroughs that make up New York City with our complete guide.
Discover what to do, where to stay and what to see in New York City with our planning tool.
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Get tips, maps and everything else you'll need during your stay.
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New York City is made up of five boroughs: the Bronx, Brooklyn, Manhattan, Queens and Staten Island. Each one has enough attractions—and enough personality—to be a city all its own. Learn more about them with this guide.
The luxury accessories company Kara Ross New York, based here in NYC, is known for its bold and unique designs. Ross founded the company in 2003 with the intent to create jewelry with character and imagination. The line debuted with a fine jewelry collection, and the brand's offerings have since expanded to include handbag, boutique and gemstone collections. Ross's love of unique materials and colored stones, inspired by alternative materials like lava, jet, wood and titanium, adds a distinctive flair to both jewelry and handbags.


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VIEWS: 6 PAGES: 1 CATEGORY: Product Manuals POSTED ON: 7/27/2012 Public Domain
Fellowes $100 Gift Card for the Voyager VY 125 Laminator
http://www.monomachines.com/ For More Info Click Here ---> Simpler. Safer. Smarter. with Fellowes Laminators. ® Voyager VY 125 Laminator ™ The Voyager is the ultimate 4-roller, high-performance laminator for daily use in the large office · Exclusive AutoLam™ technology self-adjusts to optimal laminating setting for the pouch and document you use · Advanced belt drive transport system guides document through laminator for efficient, jam-free performance · Laminator saves time by self-adjusting to pouch size and document thickness – no more waiting for machine to cool down or heat up · Auto Reverse mode detects misfeeds or overloads and reverses document flow for easy removal · Unique clam shell design makes machine easy to access for cleaning, maintenance, or misfeed removal · Includes a laminating starter kit (contents: 10, 3 mil letter pouches) · 2 year warranty Entry List Item No. Description Mil Color Width Price 5218601 Voyager 125 10 Silver/Black 12.5" $839.95 *For more details on Fellowes products, visit www.fellowes.com To check the status of your rebate, please call 1-877-839-9935. To receive your gift card: Mail the original barcode from package and a copy of the receipt, invoice or packing slip with the completed form below. Name: ____________________________________________________ Gift Card choice - check one: Mail To: Address: __________________________________________________ Voyager Department 7872 City:_______________State: ______ Zip: ________________________ P.O. Box 5012 Stacy, MN 55078-5012 Email: ________________________ Phone: _____________________ Place of Purchase: __________________________________________ Offer valid only on purchases of the Fellowes Laminator models listed in this flyer made between 10/1/12 and 12/31/12. Request must be postmarked by 1/31/13. Allow 6-8 weeks for delivery. Cannot be combined with any other offer. Not responsible for lost, late, misdirected, postage due or undeliverable mail. Illegible or incomplete requests will not be honored. Fellowes dealers, distributors and their employees are ineligible. Void where prohibited, licensed, restricted or taxed by law. Offer only valid for purchases made in the USA. Not valid on clearance items. Dunkin' Donuts is not affiliated with Fellowes, Inc. and shall not be considered a sponsor or co-sponsor of this Program. The Dunkin' Donuts trademarks, logos, and designs are registered trademarks of DD IP Holder LLC and used under license. © 2009. DD IP Holder LLC. All rights reserved. Exxon Mobil Corporation is not a sponsor or co-sponsor of this promotion. The Exxon and Mobil logos are registered trademarks of Exxon Mobil Corporation or one of its subsidiaries. ExxonMobil Gift Cards are issued and sold by SVM, an Illinois Limited Partnership. http://www.monomachines.com/
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We will be showcasing all of our programs; infants, toddlers, preschoolers, Pre-K, Jr. Kindergarten, Kindergarten, and our Elementary School age program.
There will be music, food, children's activities, and tours for prospective families.
We are also having Open House Fall Registration specials, but you can only take advantage of them if you stop by!
# # #
We are an NC 5 star licensed preschool of academic excellence, not just a daycare. We utilize a standards driven, year-round curriculum that is designed and updated quarterly by professional child care educators exclusively for Kids R Kids.


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Minocqua Triathlon
August 8, 2015Woodruff
The Triathlon offers both sprint and distance events. The swim, bike and run courses will challenge athletes among the woods & waters of the scenic Northwoods. The triathlon will be staged at Clear Lake Picnic area off Hwy J. The out & back swim will be followed by a bike course along the bike lane on Hwy J & on to Hwy E through wooded back roads. The run will be on the historic & scenic Raven Trail. Volunteers in kayaks & SUP's will provide safety during the swim portion. Music, food and beverages – for athletes, friends, families and spectators.
Event Date Detail
Aug 8, 2015


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You can indicate the ring size, special gift wrapping or any other request to the designer at checkout.
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DHL Express: 2 - 5 days from dispatch.
These studs are handmade using Hallmarked Sterling Silver and are plated with 18ct Yellow Gold.
A little 5mm gear sits on top of an 8mm to make these sweet little studs.
Combining traditional clock making techniques and an innovative take on jewellery design has resulted in a collection which creates a beautiful amalgamation between the two. The beauty of horology has forever remained hidden into the cases of clocks and watches, however in this collection pieces are momentarily separated from time to create pieces of jewellery.
Inspired the combination of different sized gears found inside watches, these gorgeous little studs feature a 5mm gear on top of an 8mm gear. Clarice has used traditional watch making machines to cut the little teeth around the edge of the gears to make them look like real gears.They look lovely paired up with the Double Winding Wheel Ring and the Double Winding Wheel Necklace to create a beautiful set! These studs are lovingly handmade in Hallmarked Sterling Silver and come plated in 18ct Yellow Gold. P.O.A for solid 9ct and 18ct Yellow Gold and diamond pieces, please email me for more information.Please note this piece is handmade to order so allow 2-3 weeks for delivery.All pieces come beautiful wrapped with Clarice Price Thomas branded packaging.
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- Lectures
Advanced Stage Prostate Cancer Treatment Options
- The Advanced Stage Prostate Cancer Treatment Options will be held at the Lucy Curci Cancer Center on Monday, September 10 2012 from 05:30PM to 07:00PM.
Recent advances in the treatment of prostate cancer are providing many more treatment options for men diagnosed with advanced stage prostate cancer.
Dr. Tsai will present an overview of such new drugs as sipuleucel-T, cabizitaxel, abiraterone and MDV3100. Complimentary light dinner included.
- Registration for this event has closed.
- 169


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On Tap Today: Filling your holiday calendar
Eggs, bunnies, and a spring in your step. There are lots of ways to celebrate Easter and vacation break. Weekend Cue offers a rundown of what's happening for everyone in the family.
Perhaps it's sounds of the season that lure you this weekend. The Milwaukee Symphony Orchestra celebrates "The Glory of Handel" Friday at the Marcus Center. »Read Full Blog Post
Wolf Peach halting lunch service in July but extending dinner, brunch hours
Diners have about a week to get the house brat or the fried halibut sandwich (both on house-made buns) at Wolf Peach: The last lunch service will June 28.
Chef Dan Jacobs said the restaurant is busy for weekend brunch and dinner, but less so for weekday lunch. He speculated that the nearby Pleasant St. Bridge's being out because of reconstruction could be a contributing factor. »Read Full Blog Post
This week's concerts
8 p.m. Saturday, Shank Hall, 1434 N. Farwell Ave. $20 at the box office, (866) 468-3401 and ticketweb.com. »Read Full Article
Concert Update
Megan & Liz with Kalin and Myles: 7 p.m. Aug. 9, the Rave, 2401 W. Wisconsin Ave. $12, on sale 10 a.m. Friday at the box office, (414) 342-7283 and therave.com. »Read Full Article
Get to know these young bands and who they resemble
Last December, Walk the Moon headlined a sold-out show at Turner Hall Ballroom. Thursday it will open for Grammy-winning hit-makers fun. at the Marcus Amphitheater. But in 2011, the pop band from Cincinnati was just one of 44 bands trying to make a name for itself, performing at Summerfest as part of the Big Gig's annual Emerging Artist Series.
Taking place from 3 to 7:30 p.m. daily at Summerfest's U.S. Cellular Connection Stage, the Emerging Artist Series showcases budding acts from Milwaukee and beyond. »Read Full Article
Podcast: The incomparable 'Sergeant Chip' now an audio story
'Sergeant Chip,' one of the finest military science-fiction stories I've read, is now an impressive audio novella, thanks to the StarShip Sofa podcast.
Bradley Denton's novella, which won the 2005 Theodore Sturgeon Memorial Award for best short science fiction, is narrated by the title character, a black Labradoodle and military canine who has been enhanced so he can receive telepathic commands from his human handler. It is one of the finest explorations I've encountered of what it means to be a good soldier. »Read Full Blog Post
James Gandolfini's top five movie roles
It seemed that James Gandolfini, star of "The Sopranos" who died Wednesday at the age of 51, was so associated with the mobster Tony Soprano that Hollywood did not know what to do with him.
According to TV Guide editor Bruce Fretts, Gandolfini was a character actor at heart before "The Sopranos" and after. »Read Full Blog Post(1)
U.S. Bank fireworks show July 3 to feature 10,000 pounds of fireworks
The annual U.S. Bank fireworks show will light up the sky over Milwaukee's lakefront July 3 with 10,000 pounds of fireworks, the bank said Thursday.
The show, launched from two barges on Lake Michigan off of Veterans Park, begins at 9:30 p.m. The fireworks won't be rescheduled if there is severe weather. »Read Full Article(5)
German-American choruses offer free weekend concerts
German-American choral groups from around the country will give two free concerts in downtown Milwaukee this weekend as part of Sängerfest 2013.
The choral festival, held every three years, will bring more than 1,200 singers to the city. The last time Sängerfest was held in Milwaukee was 1973, said Gary Luther, a member of Milwaukee Liedertafel and president of the Wisconsin district of Nord-Amerikanischer Sängerbund, the North American Singers Association. The Wisconsin district is serving as festival host. »Read Full Article
Fund-raiser Dining out for Life on Thursday
Dining out for Life, an annual fund-raiser for One Heartland camp and the AIDS Resource Center of Wisconsin, takes place at participating restaurants, bars and food trucks and carts today -- starting with breakfast.
The businesses contribute a percentage of their sales to the chariites. »Read Full Blog Post
On Tap Today: Free beer, 48 Hour Film Project, Ladysmith Black Mambazo
Rally your friends and find your dormant lederhosen to celebrate the opening of the long-anticipated improvements to the Estabrook Beer Garden. The German-inspired outdoor drinking spot will tap a keg during opening ceremonies, which start at 5:30 tonight, and pour free, imported Munich Hofbräuhaus beer until 9 p.m. Bring your own beer stein or use one for a $5 refundable deposit.
Two Milwaukee teams accepted the challenge to write, shoot, edit and score a movie in just 48 hours last weekend. Sound like an adrenaline rush? Or maybe just a disaster waiting to happen? You decide. View "Group A's" films from the 48 Hour Film Project at 7 tonight at the Oriental Theatre, 2230 N. Farwell Ave., for $10. "Group B" premieres right after at 9 p.m. »Read Full Blog Post


text:
results for "14 year old vagina exam photos", only photos
displaying 1-30 out of 246
True exam
This is an exam of a student for his "Intro to Communication" class. It came back with this letter written by his professor:
Greek cult or slut?
I am still not sure if this is an accident or a well played move to get attention.
Exam answers 1
Student with a sense of humor or a messed up child?
Here is the North Pond Hermit after living 27 years in the woods of Maine, completely isolated from people


text: TimDan2 By Steve Tanko June 15, 2012 2:41 PM Share on Facebook Share on Twitter Category: Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of Kool 101.7 Rolling Stones Announce Exhibition at London's Saatchi Gallery Lionsgate Rolls the Dice on New 'Monopoly' Movie, Hires Oscar-Nominated Writer Easy Tips for Keeping Your Dog's Paws Safe in the Hot Sun Journey Drummer Deen Castronovo Faces Charges of Rape, Sexual Abuse and Assault Recommended For You Best of the Web