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The Lead
Researchers "smell" new receptors that underlie many actions of anesthetic drugApril 2, 2015 3:48 pm | by Univ. of Pennsylvania | News | Comments
Penn Medicine researchers are continuing their work in trying to understand the mechanisms through which anesthetics work to elicit the response that puts millions of Americans to sleep for surgeries each day.
Scientists win $3.3M grant to accelerate treatment development for intellectual disability, autism, epilepsyApril 2, 2015 3:40 pm | by The Scripps Research Institute | News | Comments
Scientists from the Florida campus of The Scripps Research Institute have been awarded $3.3...
Tiny nanoparticles could make big impact for patients in need of cornea transplantMarch 9, 2015 12:01 pm | by Johns Hopkins Univ. | News | Comments
Animal study shows that a nanoparticle applied at the time of surgery slowly releases needed...
Cerebral palsy - it can be in your genesFebruary 12, 2015 11:29 am | by Univ. of Adelaide | News | Comments
An international research group led by a team at the University of Adelaide has made what they...
Evolution of a natural gene network explored by Yale researchersFebruary 12, 2015 11:24 am | by Bill Hathaway, Yale Univ. | News | Comments
Scientists have extensive knowledge of how mutations of single genes during evolution can have a fitness cost or benefit for the host organism. However, genes are often embedded into complex regulatory networks. The role of these gene networks in evolution is less well understood.
Johnson & Johnson projects aim to spot who'll get a diseaseFebruary 12, 2015 10:58 am | by Linda A. Johnson, AP Business Writer | News | Comments
Imagine being able to identify people likely to develop a particular disease - and then stop it before it starts.
Top 10 challenges facing global pharmaceutical supply chainsFebruary 3, 2015 8:25 am | by Robert Polner, New York Univ. | News | Comments
Ten years after the 2005 Paris Declaration on Aid Effectiveness reported on the need for better coordination in the global fight against disease, global pharmaceutical supply chains remain fragmented and lack coordination, facing at least 10 fundamental challenges, according to a newly published paper.
Ebola vaccine trial suspended after side effectsDecember 11, 2014 12:12 pm | by Associated Press | News | Comments
Swiss researchers have suspended the testing of one of the leading Ebola vaccine candidates after some volunteers reported unexpected side effects.
Scientists to use tiny particles to fight big diseasesOctober 23, 2014 12:49 pm | Videos | Comments
A group of scientists in Florida have combined medicine and advanced nanotechnological engineering to create a smarter, more targeted therapy that could overcome the most lethal gynecologic cancer. The technology involves combining Taxol, a chemotherapy drug, with magneto-electric nanoparticles that can penetrate the blood-brain barrier.
2nd Annual Pharma Data Analytics ConferenceSeptember 29, 2014 3:10 pm | Events
The 2nd Annual Pharma Data Analytics Conference will enable senior-level analytics professionals to improve the bottom line of their business through utilizing the potential of big data. Driven by single-track case study presentations from Pfizer, Celgene, Novartis, Merck and many others, this program will explore recent trends in the pharmaceutical environment, including the influence of analytics in the commercial space, data visualization tools and techniques and methodologies for forecasting across multiple business units.
German Merck to buy Sigma-Aldrich for $17 billionSeptember 22, 2014 12:35 pm | by David McHugh, AP Business Writer | News | Comments
German drug company Merck says it has agreed to buy St. Louis-based chemical firm Sigma-Aldrich Corp. for $17 billion in a deal Merck says will strengthen its business in chemicals and laboratory equipment. Sigma-Aldrich has over 9,000 employees in 40 countries and supplies chemicals and laboratory equipment to government and commercial facilities. Its board of directors has unanimously approved the deal.
Better use of electronic health records makes clinical trials less expensiveJuly 11, 2014 12:40 pm | News | Comments
According to recent research in the U.K. , use of electronic health records to understand the best available treatment for patients, from a range of possible options, is more efficient and less costly for taxpayers than the existing clinical trial process.
Agilent collaborates with Seoul National Univ. on new research centerMay 13, 2014 7:39 am | News | Comments
Agilent Technologies Inc. has announced the signing of a memorandum of understanding with Seoul National Univ., Korea's top research university, on a new research center that will support the College of Pharmacy's New Drug Development Center. The collaboration will conduct drug metabolism studies, develop new compounds, study remedial effects and toxicity, assess pharmacokinetics, and conduct clinical tests for drugs.
Dead Cell Removal DeviceMarch 24, 2014 2:46 pm | Product Releases | Comments
AMSBIO has announced the launch of ClioCell, an ex vivo device for removal of dying and dead cells, improving viability and quality of cell populations and their subsequent productivity. The system comprises super-paramagnetic nanoparticles which have been coupled with proprietary elements that bind to dead and dying cells and cell debris.
New high-throughput method proposed for screening, ranking anti-aging drugsMarch 14, 2014 7:27 am | News | Comments
Scientists in the U.K. have proposed a new computer-based method of screening drugs that could be used to slow the aging process in humans. The proposed method uses gene expression data from "young" and "old" tissues to construct the cloud of molecular signalling pathways involved in ageing and longevity. It then evaluates the effects of a large number of drugs and drug combinations to emulate a youthful state for cells and tissues.
Doctors often uncertain in ordering, interpreting lab testsMarch 10, 2014 12:43 pm | by Sharon Parmet, Univ. of Illinois Chicago | News | Comments
Over the past 20 years, the number of laboratory tests available to primary care physicians has doubled, to more than 3,500 tests, and physicians are challenged by the quantity of tests available. A recent survey conducted by the U.S. Centers for Disease Control and Prevention suggests they often face uncertainty in ordering and interpreting clinical laboratory tests, and would welcome better electronic clinical decision support tools.
Advanced approach identifies new drug candidates from genome sequenceFebruary 10, 2014 7:41 am | News | Comments
In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die.
Merck joins companies ending chimpanzee researchJanuary 31, 2014 8:38 am | News | Comments
Drugmaker Merck & Co. is joining two dozen other pharmaceutical companies and contract laboratories in committing to not use chimpanzees for research. The growing trend could mean roughly 1,000 chimps in the U.S. used for research or warehoused for many years in laboratory cages could be "retired" to sanctuaries by around 2020.
Study: Hybrid nanomaterials could replace human tissue, today's pillsNovember 22, 2013 8:12 am | News | Comments
A team of researchers has uncovered critical information that could help scientists understand how protein polymers interact with other self-assembling biopolymers. The research helps explain naturally occurring nanomaterial within cells and could one day lead to engineered bio-composites for drug delivery, artificial tissue, bio-sensing, or cancer diagnosis.
Brain imaging reveals dynamic changes caused by pain medicinesNovember 20, 2013 8:39 pm | News | Comments
Univ. of Michigan researchers are the first to use brain imaging procedures to track the clinical action of pregabalin, a drug known by the brand name Lyrica that is prescribed to patients suffering from fibromyalgia and neuropathic pain. The study suggests role of brain imaging in creating personalized treatment of chronic pain.
Cheminformatics SoftwareSeptember 24, 2013 12:31 pm | Product Releases | Comments
Accelrys Inc. has announced the release of Accelrys Insight and Accelrys Insight for Excel, completing the roll-out of Accelrys' next-generation cheminformatics suite and providing an interactive, collaborative environment for rapid and effective decision-making in drug discovery.
NSF report details increase in business research and developmentSeptember 20, 2013 12:25 pm | News | Comments
According to a recent study published by the National Science Foundation (NSF), businesses spent more on research and development (R&D) in 2011 than they did in 2010. The figures revealed that during 2011, companies in manufacturing industries performed $201 billion, or 68%, of domestic R&D.
When writing antibiotic prescriptions, doctors favor strongest drugsAugust 1, 2013 1:55 pm | News | Comments
A study at the Univ. of Utah finds that more than 60% of antibiotic prescriptions are for types that kill multiple kinds of bacteria. Unfortunately, in more than 25% of cases such prescriptions are useless because the infection stems from a virus, which cannot be treated with antibiotics. This overuse of antibiotics has a number of downsides.
Chemical reaction could streamline manufacture of pharmaceuticalsJuly 23, 2013 8:50 am | News | Comments
Researchers in Texas have discovered a new chemical reaction that has the potential to lower the cost and streamline the manufacture of compounds ranging from agricultural chemicals to pharmaceutical drugs. The reaction resolves a long-standing challenge in organic chemistry in creating phenolic compounds from aromatic hydrocarbons quickly and cheaply.
Sigma-Aldrich, Scripps partner to accelerate reagent commercializationJuly 18, 2013 9:33 am | News | Comments
On Thursday, Sigma-Aldrich Corp.announced a partnership with The Scripps Research Institute (TSRI) to fund research and provide immediate, day-of-publication access to TSRI researchers' discoveries for the synthesis and analysis of potential drugs. The partnership promises to eliminate months from the translation of cutting-edge chemistry into widespread applications for drug discovery.
GlaxoSmithKline buys vaccine developer OkairosMay 29, 2013 4:10 pm | by The Associated Press | News | Comments
British drugmaker GlaxoSmithKline PLC said Wednesday that it will buy Okairos AG for about $323 million, gaining the Swiss vaccine developer's products. GlaxoSmithKline said Okairos is studying vaccine technology that could be used in shots that can both prevent and cure infections or diseases.
Biogen submits new MS drug for FDA approvalMay 21, 2013 3:13 pm | by The Associated Press | News | Comments
Specialty drugmaker Biogen Idec said Tuesday it submitted a new injectable multiple sclerosis drug to the Food and Drug Administration for U.S. market approval. The drug, called Plegridy, is intended to treat patients with relapsing forms of multiple sclerosis.
XenoPort MS treatment fails in late-stage testingMay 20, 2013 12:01 pm | by The Associated Press | News | Comments
Shares of XenoPort Inc. sank Monday after the drug developer said a potential treatment for multiple sclerosis patients failed in late-stage clinical testing, and it will stop developing the drug. The Santa Clara, Calif., company said the treatment, labeled arbaclofen placarbil, failed to show a statistically significant improvement for patients taking it compared to a fake drug.
FDA OKs Bristol's HIV drug for younger patientsMay 3, 2013 5:51 pm | by The Associated Press | News | Comments
Bristol-Myers Squibb Co. said Friday that U.S. regulators expanded approval of its HIV drug Sustiva to children as young as three months old. The capsule-based drug was first approved in 1998 to treat HIV-infected children who are age three and older and weigh at least 22 pounds. The new approval expands the drug's use to children age three months to three years who weigh at least 7.7 pounds.
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NEW YORK -- Lost in all the hoopla surrounding the return of Sidney Crosby is the fact there's a pretty big hockey game taking place at Madison Square Garden, too.
The Pittsburgh Penguins will be at full strength -- defenseman Kris Letang is back, too -- as they look for their 10th straight victory when they face the New York Rangers in a battle of the Eastern Conference's top two teams.
The Rangers hold a six-point edge on their Atlantic Division rivals, who hold a game in hand. While the Penguins have been surging, the Rangers have been scuffling -- they have won two straight to start a seven-game homestand, but are just 4-3-1 in March and haven't been playing their best of late.
While the Penguins are getting healthy, the Rangers are going in the opposite direction. Goaltender Henrik Lundqvist will miss his second straight game due to the flu; Ryan Callahan is out for a third straight game with a foot ailment, and defenseman Michael Del Zotto will miss his fourth consecutive game with a sore hip.
There are enough storylines in this matchup to keep writers at their keyboards for days, but for both teams, the game is all that matters.
"This game is a lot more than about Sidney Crosby coming back to our game and a comeback game for Sid," Penguins coach Dan Bylsma said. "We know that if we want to catch the Rangers and first in our division and hopefully first in the conference, we have to beat them. We're coming in here to win the two points. I don't think we can give them one point and realistically think we have a chance to get them. That's what this game is for us."
Rangers coach John Tortorella doesn't care who is in the lineup for the Penguins.
"We're worried about our club," Tortorella said. "That's all we're concerned about -- the New York Rangers."
Tortorella's players aren't looking at it as just another game, but they aren't concerning themselves with any of the hype surrounding Crosby.
"Doesn't matter," Rangers forward Brian Boyle. "They're a good team that's coming on strong. He's a good player, obviously, but it's a big divisional game. That's the biggest thing. Games get magnified toward the end of the season. That's the biggest thing."
Goaltender Martin Biron will make his second straight start -- the Rangers called up Chad Johnson from Connecticut of the AHL to serve as the backup -- and said it won't be hard to focus on the task at hand.
"We had our morning skate, and we'll leave here this morning game-ready," Biron said. "It's the same as it's always been. When we play Pittsburgh, it's always a very important matchup. It's very exciting, very emotional. With Sidney in the lineup, it adds a different dimension, but I think they've got a lot of weapons on the other side that keeps us on top of our game. It's always a special game when we play them."
Follow Dave Lozo on Twitter: @DaveLozo

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Wacky Bongo Boy
Joined: Nov 2006
Location: El Segundo, CA
Oddometer: 7,651
I wrote my letter of resignation... on my first day.
To recap:
I gradutated in May 2011 with a Bachelors in Aerospace Enigneering, minors in Mathematics, Materials, and Explosives Engineering with a Certificate in Explosives Engineering. I did three years of research/work with NASA as the president of a departmental design team. I did two years of Explosives Engineering research. I received an internship in the areospace field. I was hired by the university as a research assistant. I received scholarships. Etc, etc..
The company I interned with was in the process of mandatory layoffs around the time I graduated. So, I looked elsewhere.
I found a job where I was told I would be running Catia/Solidworks developing tools and fixtures and would have occasional access to the Haas machines, since I also knew how to run them.
On my first day, no one knew where to put me, so the production manager made me watch everyone do their jobs. He didn't warn them, so they were less than friendly or accommodating. The people in the shop bitched at me about how dumb and worthless engineers are, and I had people cussing me out and cussing the whole business out. One thing that stuck with me was, "This place fucking sucks, but you'll learn that soon enough." I waited to see what the office job was going to be like.
After 3 weeks of no one having work for me and having to watch people in the shop work, my first project in the office popped up. I didn't know at the time, but management stole information from a local IT company and had me implement the upgrade for their computers (something I had no experience with). I then had to find a computer for myself, install the operating system, and for a couple weeks I had access to Excel.
After that, there was nothing left to do and I was tossed to the shop as a CNC machinst.
That's when I started complaining about:
severe lack of ethical values (lying to customers, stealing from vendors),
my former manager got fired not for saying his racist/sexist stuff, but that he was going to shoot one of my coworkers,
the general sexism/racism,
boogers on the walls,
moldy ceiling,
no climate control,
we're not allowed chairs nor can we lean on things or take breaks other than lunch (30 minutes),
almost everyone chain-smokes all day long,
we're not allowed water or drinks,
my 90-day review was 50 days late and they didn't want to give me back-pay after they said they would,
my 180-day review never came, after which they went on a raise-freeze and refused to review me,
I often asked who my manager was or who I report to and no one could give me an answer,
turn-over being so high that at 11 months, I was pretty high up the seniority list,
being looked down on by almost every aerospace company I applied to because I'm a just a machinist and not an engineer,
Lately, the CEO started a rumor that I was having sex with one of the girls, that she should kick me in the balls when she's done with me, and that I would masturbate behind the machines when she "drove me crazy." Coupled with more long-expired promises of the potential of a computer or the chance for Catia, I decided it was time to resign. You can only suffer so much.. If I didn't know any better, I'd say they forced me out, but it's just the way they operate.
Today was my last day. Free at last.
Check out my other casting thread if you're still interested in my casting experiments/progress.
Beastly Adventurer
Joined: Oct 2009
Location: Sandhills of SC
Oddometer: 1,660
I have been enjoying your threads. Very fascinating career. I was wondering how long you would stick it out. Sounds like you lasted about 99% longer than I would have!
You paid your dues, now things will only get better.
Good luck.
De Jo Momma
Joined: Aug 2005
Location: 20 Mule Team Trail (Palmdale, Ca)
Oddometer: 12,243
You lasted longer than I would have. I would have done things my way and if they didn't like it...well...they'd probably do nothing.
I mean...seriously...if they fired you for bringing a chair out there or having something to drink, how would the state have handled that when it came time to unemployment? It wouldn't look very good for them.
Time to move on. I hope you got pictures of the bathrooms, etc. Nobody will ever believe you without them.
Wacky Bongo Boy
Joined: Nov 2006
Location: El Segundo, CA
Oddometer: 7,651
I learned that a couple years ago management put it to a vote. You can either have chairs/breaks, or you can smoke while you work. Everyone voted to smoke. So, even non-smokers weren't allowed breaks. Yay.
Now, take that metaphor and apply it throughout every aspect of the job I just had.
crazydrummerdude screwed with this post 07-03-2012 at 04:34 PM
De Jo Momma
Joined: Aug 2005
Location: 20 Mule Team Trail (Palmdale, Ca)
Oddometer: 12,243
Yeah! I want Cheesy Poofs
Joined: Feb 2003
Location: SoCal
Oddometer: 20,435
6+ months.
what took you so long? I've found that when I'm at a shit place, I can taste the poison pretty early, and about 3 months is the max I can take.
Wacky Bongo Boy
Joined: Nov 2006
Location: El Segundo, CA
Oddometer: 7,651
I wonder if I'll work in the aerospace industry again. I'd like to.
Joined: Oct 2008
Oddometer: 5
Practical experience before design
With a little hands on experience before being let loose on a design program, maybe plant maintenance MIGHT become a little easier - like heat exchangers placed where you can actually remove the tube bundle for cleaning without having to knock down a wall, and the repairman can actually reach all the bolts on the valve on the fifth pipe of ten pipes that were installed sequentially because there was no other way with the space they left, and the largest pump or motor would have clear access with overhead craneage to remove it without stripping the entire floor, or three inclined coal conveyors running parallel in the same tunnel (guess which gearbox we'll have to change first?), or firefighting piping that prevents rigging access because it crosses the centreline of the crane, or ...
Think it can't happen? Welcome to my world!
Oh, and ALL of the design work was done on computers - its just that there was no single verification of the integration of all the systems, so everyone is very proud of their little piece of genius, and nobody is to blame!
Look at the design of a racing motorcycle and you will quickly realise how important it is for the mechanics and technicians to get to everything quickly. Some of those principles have made adventure riding better, too, by allowing the rider/mechanic to help himself (if he has the appropriate practical experience, of course!)
/rant off/ - yes, I do feel a bit better, thanks
bikes, booze, broads...
Joined: Oct 2003
Location: Strangel Living West of Hell, SoCal
Oddometer: 9,661
...sounds like you worked for a pretty bad outfit...don't tell me, SoCal?
There's alot of crappy places to work, especially the one's that were 'built from scratch' and have over 50 employess.
My advice, for what it's worth, is give the big aerospace companies a shot.
Your still going to have the same bitchin' and moanin', but there are standards and ethics in place.
As I write this, I'm sitting in a NASA hangar office listening to enginerds wallering at higher than necessary volume about how procedure should be done.
Nature of the beast I reckon.
Want to give Seattle a go? Boeing in Everett is hiring.
Like I said before, CE Weekly for contractors is the best bang for the buck when it comes to getting your resume' out there.
Note: include KEY WORDS like CATIA so the resume' scanner picks them up...
'91 R100GSPD Derelict Deux , '81 R100RS Rattlecandy Red/'06 950 ADV Orangeboom/91 R100GSPD Derelict etc.
Joined: Jun 2007
Location: Where the bikes parked. STL
Oddometer: 8,623
STURGIS ride report.
2009 R1200 Gelände/Straße Abenteuer
A GS is like chlamydia, it grows on you whether you want it to or not. WhiteManFlail
Save $5 on Smugmug "1alkVgTNLEuyQ"
Cumminsman76 screwed with this post 03-13-2013 at 09:00 PM
bikes, booze, broads...
Joined: Oct 2003
Location: Strangel Living West of Hell, SoCal
Oddometer: 9,661
...cool, glad to hear that.
'91 R100GSPD Derelict Deux , '81 R100RS Rattlecandy Red/'06 950 ADV Orangeboom/91 R100GSPD Derelict etc.
Wacky Bongo Boy
Joined: Nov 2006
Location: El Segundo, CA
Oddometer: 7,651
Well, I wrote up a nice response then Firefox crashed..
After my manager was fired for threatening to kill my coworker, my new "supervisor" pointed a gun at me and pulled the trigger a few times. I told him to watch where he pointed that thing. He grabbed another gun from the table in the engineering office, and with one in each hand, put them up to his temples and pulled the triggers while saying, "What? They're not loaded! [clickclick click clickclick]" I responded, "Yeah, famous last words." He asked, "What does that mean?" I just walked out of the room. There was probably 1000 rounds of ammo laying loose on the other table.
Oh, and this was not in California. It was just south of St Louis, MO.
Now if I could just stop having dreams that I'm back there getting back-stabbed, threatened, sabotaged, guns pointed at me, etc..
Going back to the discussion about my hands-on machining and casting work; There still seems to be a disconnect somewhere among half the people I've talked to. They get hung up on the idea that it's all I had to offer in my job search*, when in reality, my "technician" or "mechanic" work is in addition to my actual engineering degree and engineering experience, not in place of. Here is my engineering skillset.. and here is my hands-on skillset. Seems like it would be an advantage, but apparently not for engineers.. we're not supposed to know how things are made or maintained, I guess. So, I'll just stick to using my hands in my garage.
*Almost all of this thread was unintentionally the development of looking for an entry-level engineering job. I never claimed to be the best engineer or the best machinist. I have these skills that I thought were a good foundation to build upon. I didn't know what a chore it would be to find a place where I could do just that.
crazydrummerdude screwed with this post 03-14-2013 at 10:34 AM
Silly Adventurer
Joined: Feb 2006
Location: wheelie in purgatory, Calgary
Oddometer: 3,604
One of the issues that has cropped up in many industries that require engineering is that a technician/labor vs. engineer mentality has arisen, and you gotta pick a team, and I think that may be what your resume may be triggering. It may have always been this way, but I think it has gotten worse for several factors that have contributed to this:
-the design and engineering to make many things has become much more complex and theoretical, which causes specialization. The skill sets required for engineers and technicians have become more disparate and complicated.
-engineers are typically made "superior" in company structure to the technicians without regard to experience (life or technical), creating much antipathy. Formal schooling seems to trump all else.
-engineering schools are typically universities where the profs are pressured to publish. This attracts a certain type of prof who often is not at their best out of the theoretical environment, and this affects what students take away from school.
-technicians are typically taught the immediate skill set they require and sometimes don't get the "big picture" perspective, however as the technical trades become more complex sometimes better analytical skills develop and technicians begin to ask more challenging questions...
-neither technicians nor engineers are looked at as models for interpersonal skills in the work environment
What I tell my students is that both have a job to do. Both can learn from each other. At times our priorities or tasks may not be perfectly in sync. There will be tension, and that isn't always bad, and in fact it is natural and useful. Find away to productively work though it, and don't exacerbate it.
Rum Runners Yukon, NWT & Alaska
Roads and Ruins Scotland
Kinbasket Lake Golden B.C.
A "Day" of Dirt Biking Rockies East Slopes
High and Dry Colorado and Utah
"When your only tool is a hammer, every problem looks like a nail"
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Have you had a Thanksgiving fiasco?
By Houston Chronicle | November 15, 2012 | Updated: November 17, 2012 2:23pm
Photo By PRWeb
Five minutes before chaos erupts...
Have you ever had a Thanksgiving dinner ruined by squabbling relatives, a frozen turkey or inebriated guests?
Ever dropped a cooked turkey on the floor?
Or insulted Aunt Bertha by asking her not to make her stuffing?
If you've had a Thanksgiving fiasco that you're willing to share, we're all ears. Send a short and sweet email to Claudia Feldman at firstname.lastname@example.com. Please include your full name and phone number. Deadline is 9 a.m. Monday.


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Underberg hasn't had to fight a specific infection in the school's smaller gymnasium, but that space requires a slightly different cleaning approach. Underberg uses the standard detergent amount when he cleans the rubber floor of the smaller gymnasium. However, since the floor is porous, he ensures it's free of germs and bacteria by increasing the water flow and reducing cleaning speed. The detergent is then able to break the surface tension of water and clean deep into the rubberized flooring's cracks and crevices.
Underberg also utilized the EcoFlex System's "burst of power" button in his efforts to prevent the potential spread of the staph infection. This feature allows the operator to increase the scrubber's detergent dilution ratio, solution flow rate and brush pressure for 60 seconds. In addition to using the burst-of-power button as a preventative measure, Underberg uses it in the school's heavily trafficked common areas.
The full text of this article may be downloaded from www.cccinc.com/pr/advcomm/w
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From the Money Matter's Desk: Disability and Work
Sep 22, 2011 The unemployment rate for Americans with disabilities is almost 40 percent. On this week's Money Matters -- our regular look at how to improve your bottom line -- we learn how to improve the hiring process from Dan Ryan, the author Jobsearch Handbook for People With Disabilities.
"Day in the Work Life": Manga Artist
Sep 22, 2011 On this week's Day in the Work Life -- our regular look at how folks trade their time for money -- we present an audio sketch of a comic book artist.
The Mailbag for December 9, 2005
Sep 22, 2011 Our economics editor Chris Farrell answers more of your burning money questions. This week: advice on investing in a life insurance annuity, using a prenuptial agreement, and securing a retirement cushion as a General Motors retiree.
From the Money Matters Desk: Mean Girls
Bob Moon
Sep 22, 2011 The glass ceiling might have been shattered. But is there another all-female barrier? On this week's Money Matters -- our regular look at how to improve your bottom line -- Nan Mooney shares insight from her new book, Why Women Betray Other Women at Work.
Off Ramping
Sarah Gardner
Sep 22, 2011 Many moms have taken a detour from the fast track to stay home with their kids. But what happens when they want to merge back into their career? Work and Family correspondent Sarah Gardner reports.
The "Straight Story" with Chris Farrell: Don't Hedge Bets
Dec 2, 2005 It's time once again for economics editor Chris Farrell is to help you sort out what's smart, what's stupid and what's the "Straight Story." Hedge funds are feasting on investments from pensioners. Chris says it's a recipe for disaster.
"Day in the Work Life": Judge
Sep 22, 2011 On today's "A Day In the Work Life" -- our weekly look at how folks trade time for money -- we sit on the bench with a Superior Court Judge.
Bonus Time!
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Cat Zingano had been scheduled ot fight UFC Women's Bantamweight Champion Ronda Rousey, but injured her knee, and was replaced by Miesha Tate. Although recovering from difficult knee surgery, Zingano had a small request for Rousey.
Alpha Cat Zingano @CatZingano
Alpha Cat Zingano @CatZingano
Ronda Rousey @RondaRousey
Mauricio Zingano @zinganobjj
Ronda Rousey @RondaRousey
Tate and Rousey will be fighting at the TUF 18 finale.
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Recent Comments »
6/20/13 10:42 AM by DamnSevern
She sounds like an immature teenager Bad form
6/20/13 10:37 AM by jman
I was thinking the same thing this last UFC.Enough with the guys touching gloves and FFS hugging when the final round starts...ladies have a chip on their shoulder and something to prove and they seem to always bring it.
6/20/13 10:35 AM by fightharder
The hate is strong with this one..,Witchy does not seem able to make a lot of friends. Damm girls just hate the fuck out of her. She is still hot though. Hope Roussey does not pulvers her looks. Probably not, another armbar coming up. Not really that interested in the fight.Mcmann vs Roussey is still the fight i want to see, in a while.
6/20/13 10:30 AM by 2JupitersTooMany
Oh I like this new member
6/20/13 10:19 AM by ChrisAllen
It's funny how different the men and women talk shit to each other. Not to mention the smileys and lols.
6/20/13 10:07 AM by john_d1974
nice 1st post lol.
6/20/13 7:04 AM by JustAnotherMMAFan
You mean three seconds (or less!) of jabbing means outstriking?Ronda just jabbed her way into a clinch. She never meant to stand and just strike, until Sarah was k.o.ed! That's NOT outstriking, which would happen if both girls were standing and trying to k.o. each other with strikes.
6/19/13 7:56 PM by Vikingknee
Meisha is the hottest. But has the worst personality. Cat and Ronda seem like they love to get the D. Tate seems like she thinks she runs shit
6/19/13 6:34 PM by UGCTT_UncleCreepysDingleberries
Yeh I bet Cat really needed your apology you dumb fuck
6/19/13 6:31 PM by tbi0904
Unless Cyborg can make 135 or the UFC opens a women's 145 division that fight's not happening. Meisha will get crushed again and Kat Williams will get her shot. McMann (provided she gets by Kaufman) will be on deck after that. Plenty to look forward to.


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A chip mounting assembly includes a dielectric substrate having at least one integrated circuit (I/C) chip mounted thereon. An electrically conductive cover plate is in contact with all the chips with an electrically non-conducting thermally conducting adhesive. A stiffener member is provided which is mounted on the substrate and laterally spaced from the integrated circuit chip. At least one electrically conductive ground pad is formed on the substrate. The stiffener has at least one through opening therein and electrically conductive adhesive extending through each opening and contacting the cover plate and each ground pad.
1. A chip carrier and chip assembly comprising:
a dielectric substrate having at least one I/C chip mounted thereon;
an electrically and thermally conductive cover plate connected to said at least one chip with an electrically non-conductive, thermally conductive material;
a stiffener member mounted on said substrate and having a chip receiving through opening therein which at least partially surrounds said I/C chip;
at least one electrically conductive ground pad mounted on said substrate;
said stiffener member having at least one through conductive material receiving opening therein; and
electrically conductive material disposed in said at least one conductive material receiving opening and electrically connecting said cover plate and said at least one ground pad.
2. The assembly of
3. The assembly of
4. The assembly of
5. The assembly of
6. The assembly of
7. The assembly of
8. The assembly of
9. The assembly of
10. The assembly of
11. The assembly of
12. The assembly of
13. The assembly as defined in
1. Field of the Invention
This invention relates generally to I/C chip mounting structures which include a substrate and an electrically and thermally conducting cover plate and a method of manufacturing the same. In even more particular aspects, this invention relates to an I/C chip assembly which electrically insulates the chip from the cover plate but provides grounding of the substrate to the cover plate.
2. Background Information
In the packaging of I/C chips, there has developed a need for a chip package that includes a cover plate for the assembly, which cover plate is thermally conducting for heat transfer, and also electrically conducting for grounding the substrate, while preventing the chip itself from being electrically grounded to the cover plate, so that the cover plate can act as both a heat sink for the chip and also an electrical ground for the substrate.
According to the present invention, a chip mounting assembly is provided which includes a dielectric substrate having at least one integrated circuit (I/C) chip mounted thereon. An electrically conductive cover plate is in contact with said at least one chip by an electrically non-conducting thermally conducting material. A stiffener member is provided which is mounted on the substrate and laterally spaced from the integrated circuit chip. At least one electrically conductive ground pad is formed on the substrate. The stiffener has at least one through opening therein and electrically conductive material extending through said at least one opening and contacting said cover plate and said at least one ground pad. The invention also provides a method of forming such an I/C chip assembly.
FIG. 1 is an exploded view of a substrate, a stiffener and a thermal adhesive in position for lamination as a first step in the process of forming the device of the present invention;
FIG. 2 is a perspective view showing the substrate stiffener and a film of adhesive material laminated together to form the basis for forming the present invention;
FIGS. 3-10 are longitudinal, sectional views, somewhat diagrammatic, showing the steps in forming an I/C chip assembly according to this invention, and
FIG. 11 is a flow chart of the steps involved in preparing the chip assembly.
The present invention provides an I/C chip assembly which includes a substrate mounting one or more I/C circuit chips and, optionally, other devices, wherein the chip assembly includes a cover plate which acts as a heat sink by being connected by an electrically non-conductive, thermally conductive adhesive to the chip, and which cover plate also is connected by an electrically conductive adhesive to ground pads on the substrate to provide a ground for the substrate.
As seen in FIG. 1, a generally conventional dielectric substrate 10 is provided which has a series of mounting pads formed thereon (other circuitry and features have been omitted for clarity). The mounting pads include a group of mounting pads 12 which are for mounting an I/C chip; a group of mounting pads 14 for mounting capacitors, and a group of mounting pads 16 for providing electrical connections for grounding purposes to a cover plate. The substrate 10 can be made of any conventional dielectric material, such as FR4, polyimide, polytetrafluoroethylene or other dielectric materials,
A dry film of adhesive material 18 is provided. The film of material 18 has a central opening 20, a plurality of side openings 22 and a plurality of corner openings 24 formed therein. The opening 20 corresponds to and is in alignment with the set of mounting pads 12; the openings 22 correspond to and are in alignment with the mounting pads 14, and the openings 24 correspond to and are in alignment with the ground pads 16. Preferably, the film of material 18 is a dry film adhesive, such as a polyimide/acrylic adhesive of the type sold under the trademark Pyralux by duPont. However, any film adhesive which can have openings formed therein can be used.
A stiffener member 26 is provided which preferably is formed of stainless steel, preferably 400 Series, and, more particularly, 420. The stiffener 26 has a central opening 28 which corresponds to and aligns with the opening 20 in the film material 18, side openings 30 which correspond to and align with the openings 22 in the film 18 and corner openings 32 which correspond to and align with openings 24 in the film 18.
The substrate 10, film 18 and stiffener 26 are laid up in a lamination press and heated to about 150� C. at 300 psi gauge for about an hour and a half to form a laminate of these three items, as shown in FIGS. 2 and 3. (The preferred sequence for forming the chip assembly is shown in FIG. 10).
Alternatively, instead of a separate dry film, adhesive 18 can be replaced with a liquid adhesive which can be applied to the stiffener 26, and this will be used as the adhesive to secure this stiffener to the substrate. The liquid adhesive can be any one of several adhesives; a particularly useful adhesive is GE 3281 manufactured by General Electric Corporation.
Following the lamination process, an I/C chip 34 is mounted on the pads 12, and capacitors 36 are mounted on the pads 14 by conventional solder reflow techniques, as shown in FIG. 4. Following the attachment of the I/C chip 34 and capacitors 36, conventional underfill material 38 is applied around the solder connections of the chip 34 to the substrate and the capacitors 36 to the substrate, as shown in FIG. 5. Conventional underfill material preferably is an epoxy with silica filler, such as Namics 8437-2 sold by the Namics Corporation, although other materials can be used. The Namics 8437-2 underfill 38 is cured at about 150� for about one hour at atmospheric pressure.
Following the application of the underfill 38, a conductive material such as a conductive adhesive 40 is applied over each set of the ground pads 16 and in the openings 24 and 32 of the dielectric film 18 and stiffener 26, respectively, as shown in FIG. 6. Any type of conductive adhesive can be used. A preferred adhesive is Able Stik 965-1L, which is an epoxy with silver flakes therein, sold by Able Stik Chemical Corporation. Other conductive materials such as conductive inks may be used.
Following the deposition of the conductive epoxy 40 on the ground pads 16, a generally circumferential layer of electrically conductive material 42, preferably the same material as the material 40, is provided which is disposed over both the material 40 and the capacitors 36 and in the openings 22 and 30 in the adhesive film 18 and the stiffener 26, respectively. Care must be taken that this conductive material 42 does not extend over and into contact with the I/C chip 34 since the conductive material 42 eventually will serve to provide the electrical connection between the ground pads 16 and the cover plate, which will be described presently, and which would short out the chip 34 and cause the assembly to be inoperable. This step in the process is shown in FIG. 7.
Following the deposition of the conductive material 42, a non-electrically conductive, thermally conductive material, preferably an adhesive 44 is applied over the I/C chip 34 and in the openings 20 and 28 in the adhesive film 18 and 26, respectively. The adhesive material 44 is preferably a silicone material having a filler therein. A particularly useful material is sold by General Electric Corporation under the trademark GE 3281. However, other thermally conductive, non-electrically conducting materials can be used. This step is shown in FIG. 8.
A cover plate 46 is placed overlying the adhesives 42 and 44. The cover plate 46 functions both as a grounding device and as a heat sink and, thus, a good electrically and thermally conducting material is preferred for the cover plate 46. A particularly useful material is copper, although other metal plates could be used. As can be seen in FIG. 9, the cover plate 46 is electrically connected through adhesives 42 and 40 to the ground pads 16 on the substrate 10, and the I/C chip 34 is connected through electrically non-conducting, thermally conductive adhesive 44 to the cover plate 46. Thus, the cover plate 46 operates both as a heat sink with respect to the I/C chip 34 and a ground connection with respect to the substrate 10. The assembly is cured for approximately one hour at about 150� C. at atmospheric pressure to provide the final heat chip assembly.
A plurality of ball grid array solder ball connectors 48 are applied to the bottom surface 50 of the substrate 10, as shown in FIG. 10. These provide the necessary connections to attach the I/C chip assembly to a printed wiring board.
The various steps of forming the I/C chip assembly are shown in FIG. 11.
While the invention has been described using but a single I/C chip and various capacitors, it is to be understood that several I/C chips could be mounted on the substrate as well as other devices besides or in addition to capacitors. The important thing is that the conductive adhesive not come in contact with any of the I/C chips or any other device which could be unintentionally electrically grounded. Therefore, it is evident that many alternatives, modifications, and variations will be apparent to those skilled in the art in light of the foregoing teachings. Accordingly, the invention is intended to embrace all such alternatives, modifications and variations as fall within the spirit and scope of the appended claims.
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Originally written on Fox Sports Ohio | Last updated 12/8/12
CLEVELAND -- Five straight. Nine of 10. Fifteen of 17. If there's one constant this season, it's that the Cavaliers are finding ways not to win. They've done it while trailing for an entire game. They've done it while leading late in the fourth quarter. They've done it by keeping things close and by getting blown out (although, in their defense, not much of the latter). And they did it again Saturday, at home, against a Detroit team that entered the game with a 1-10 road record. Well, make it 2-10, as the Pistons left the building with a 104-97 victory behind a career-high 30 points from Brandon Knight. Knight is a second-year guard who went 5-for-6 on three-pointers, and just generally made the Cavs miss their own second-year guard. That would be none other than Kyrie Irving, who's been out several weeks with a broken finger. As you know, first-year guard Dion Waiters has also been out, with a sprained ankle. The Cavs were 2-8 with those two. They're considerably worse than t...
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Fr. 7a $10 1861 Demand Note PMG Very Fine 30 EPQ.. ...
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The First Piece of United States Federal Currency Ever IssuedFr. 7a $10 1861 Demand Note PMG Very Fine 30 EPQ.
A truly fantastic note which has been off the market since its last auction appearance forty-four years ago in a 1970 Sotheby's sale. It is one of only three Fr. 7a's known, and is additionally the only serial number 1 with the handwritten "For The" known from any of the issuing locations. Although many notes claim the title of "first" note issued by the United States, this is unquestionably the real deal, as the handwritten "For The" Demand Notes were the first of the Demand Notes, with the initial issue starting in 1861 while the "Greenback" Legal Tender Notes were not issued until 1862. Adding to this note's luster and historical importance is its pedigree, which, according to the description in the Sotheby's catalog, began with its presentation to Secretary of the Treasury Salmon P. Chase and thence from Chase to financier and Philadelphia banker Jay Cooke, whose efforts to raise funds for the struggling Union cause were instrumental in financing the Civil War. Any estimate here is nothing more than a mere conjecture, as no comparable piece exists, but the combination of rarity, desirability, historical importance and grade easily takes this comfortably into the six figure range, and likely considerably higher.
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It's hard to find a classroom today without some form of technology. But does investing in technology pay off in terms of test scores? Does outfitting every student with a laptop or iPad necessarily mean they are learning better?
The New York Times takes a close look at the the Kyrene School District in Chandler, Arizona. After a ballot initiative was passed in 2005, the Kyrene School District has spent roughly $33 million on technology. Its classrooms are outfitted with laptops, Smart Boards (like that in the photo above) and software to drill students on basic subjects. Teachers are supposed to be guides rather than lecturers to students who work at their own pace by using the resources of the Internet.
For its efforts, the Kyrene School District was pronounced a model of success by the National School Boards Association, which orchestrated a visit of 100 educators from 17 states to see Kyrene's innovations in 2008.
But since 2005, Kyrene students' scores in reading and math have "stagnated," while scores for the rest of the state have risen.
"Pretty Weak" Evidence
Tom Vander Ark, the former executive director for education at the Bill and Melinda Gates Foundation, acknowledges that data for the educational value of extensive investments in technology is "pretty weak." As the New York Times says, there simply isn't much research showing that technology-centric teaching improves student learning.
Many studies have found that technology has helped individual classrooms, schools or districts. For instance, researchers found that writing scores improved for eighth-graders in Maine after they were all issued laptops in 2002. The same researchers, from the University of Southern Maine, found that math performance picked up among seventh- and eighth-graders after teachers in the state were trained in using the laptops to teach.
Bryan Goodwin, spokesman for Mid-continent Research for Education and Learning, makes the point that "rather than being a cure-all or silver bullet, one-to-one laptop programs may simply amplify what's already occurring — for better or worse." Teachers who know what they're doing will make good use of the technology while teachers who don't will not.
A review by the Education Department in 2009 of research on online courses — which more than one million K-12 students are taking — found that few rigorous studies had been done and that policy makers "lack scientific evidence" of their effectiveness. A division of the Education Department that rates classroom curriculums has found that much educational software is not an improvement over textbooks.
Larry Cuban, an education professor emeritus at Stanford University, said the research did not justify big investments by districts.
"There is insufficient evidence to spend that kind of money. Period, period, period," he said. "There is no body of evidence that shows a trend line."
Just having a computer in a classroom is no guarantee of successful student learning and can even simply promote student distraction.
Read more: arizona, back-to-school, computer, education, innovation, ipad, physical education, school budget, schools, smart board, standardized test, students, technology
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Youve put enormous insights about the topic here, continue the good work!
Thank you for sharing.
Thank you.
Thank you.
Not absolutely, but helps a lot
I think so in today's world.........with all the advances and mandatory technological skills needed in school, college, on most all jobs, etc.
I agree that we are woefully behind - the 19th Century reference was apt - in structuring our educational experience to develop the nation's children for the world that they will face. Technology can help if it is properly integrated into the curriculum. In fact, failing to do that will prove disastrous and force children into a huge waste of time preparing for tests that don't really measure what needs to be measured in this rapidly developing environment. Of course the basics need to be learned, but do they have to write with quill pens and use abacuses in order for it to be considered legitimate? Teachers need more than ever to be constantly updating their skills, both pedagogical and technological, if they are to be relevant. The tools have to be there, and the teachers better be prepared to show how they are to be used.
Technology is a TOOL. Its effectiveness depends on how it is used. The "new technology" movement in education is putting it to use to tremendous effect to revolutionize the entire process of education in America ... Something that is LONG overdue.
Face it, we are still stuck in a 19th century "factory model" of education, and are preparing students for jobs that no longer exist. We have to break that mould, and create a new paradigm in education that will lead us to making education relevant to today's challenges. Mass customization and modern content delivery systems (both of which are likely to depend heavily on technology) will be a big part of that transformation.
Using modern technology to prop us an outmoded educational paradigm is an exercise in futility. New THINKING is needed, and bold new directions are vital to our nation's future success.
If a child learns because of interest, that's the important part. If a teacher can make a subject great they have won the battle no matter how the are teaching. There needs to be some action between student and teacher not machines.
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Thanks for posting.
I have two cats, Loto, the oldest, and Afrodita. And Kyra, my dog. Between Afrodita and Kyra, who are…
Thank you for the info! I have one dog that ravels fine, but my one boy is very high strung and starts…


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Cinemark Purchases 10 Acres in Roanoke, Texas New multiplex will feature Cinemark's NextGen Cinema Design Concept with a Cinemark XD auditorium Business Wire PLANO, Texas -- May 30, 2013 Cinemark Holdings, Inc. (NYSE: CNK), one of the world's largest motion picture exhibitors, today announced that it has closed on 10 acres of land to construct a new 14-screen, all-digital movie theatre in Roanoke, Texas. The complex will feature the company's new Cinemark NextGen design concept. Scheduled to open in Spring 2015, the new multiplex will be located north of Ft. Worth at the junction of Highway 170 and Highway 114. When completed Cinemark will have 21 theatres serving the DFW area. Long recognized as a pioneer in the theatrical exhibition industry, Cinemark is taking the cinema entertainment experience to the next level. The new Cinemark NextGen theatres will offer the latest technology, cutting edge amenities and customer-preferred options all under one roof. NextGen amenities will include: *State-of-the-art viewing environment with wall-to-wall, ceiling-to-floor screens available in all auditoriums *4K digital projection powered by Barco projectors; RealD 3D capability *Enhanced, sound systems that will enable customers to hear the movie as the filmmakers intended *Cinemark's innovative self-serve concession stand – offering freshly-popped popcorn, Coca-Cola fountain beverages and favorite candy brands *Cinemark XD: Extreme Digital Cinema auditorium Information about Cinemark XD: Extreme Digital Cinema auditoriums: Cinemark will be bringing their exclusive large screen format, Cinemark XD: Extreme Digital Cinema, auditorium to Roanoke. Cinemark XD is a complete entertainment environment featuring a large wall-to-wall and ceiling-to-floor screen, plush seating and a custom digital surround sound system featuring the latest in sound technology. The digital images are delivered by a Doremi server and a Barco DLP digital projector, which offers the brightest light standards in the industry. The XD auditoriums will exhibit the newest movies every week, including 2D and RealD 3D pictures. "We are excited to introduce our new Cinemark NextGen movie theatre experience to the Roanoke community," states Tim Warner, Cinemark's Chief Executive Officer. "We are confident that our state-of-the-art facility will be a welcome addition to this growing area of the Dallas-Ft. Worth metroplex." "With the commitment of Cinemark, a national entertainment industry giant, to anchor the Roanoke Gateway project it emphasizes the importance of the Highway 170 & Highway 114 location within the City of Roanoke, Texas," comments Roanoke Gateway Project Manager, Donald L. Silverman. "As the retail complex's main attraction, Cinemark's NextGen Cinema will be the entertainment destination choice for the northeast Tarrant 114 corridor and the rapidly growing areas in south Denton County." "Cotton Patch Café is excited to be a part of the Roanoke Gateway Development and Cinemark's newest theatre," states Larry Marshall, President of Cotton Patch Café (41 locations, TX, NM, OK). "It's sure to be a great site for dining and entertainment for Roanoke and the entire Denton and Northeast Tarrant County area." "We are thrilled to partner with Cinemark and be able to offer our patrons the entertainment they seek to add to their experience in The Unique Dining Capital of Texas," comments the Mayor of Roanoke, Carl E. "Scooter" Gierisch. "We look forward to all the increased opportunity that this development will bring to Roanoke as folks come here to Dine, Shop and Play!" Cinemark takes pride in creating the best entertainment experience in the industry. In order to make movie-going as easy and enjoyable as possible, Cinemark focuses on offering more choices to their customers. For example, the new theatre will feature online "Print at Home" ticketing, available at www.cinemark.com, which will make it easy for patrons to purchase tickets in advance from the comfort of their home or office. Customers will be able to bypass lines at the box office and go directly to a kiosk in the theatre lobby. Also, guests can download and purchase tickets through Cinemark's mobile applications that are available for iPhone and Android phones. Finally, to stay connected, customers can sign up online to receive free, weekly showtime emailers that contain online coupons for discounts at the concession stand and other weekly special offers. About Cinemark Holdings, Inc. Cinemark is a leading domestic and international motion picture exhibitor, operating 467 theatres with 5,259 screens in 39 U.S. states, Brazil, Mexico, Argentina and 10 other Latin American countries as of March 31, 2013. For more information go to www.cinemark.com. Contact: Cinemark Holdings, Inc. James Meredith, 972-665-1060 VP, Head of Marketing & Communications firstname.lastname@example.com
Cinemark Purchases 10 Acres in Roanoke, Texas
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1871 H10C Half Dime, Judd-1062, Pollock-1197, R.7, PR65 ...
2003, Orlando, FL. (FUN) Signature Sale #308
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Originally and Carefully Preserved 1871 Pattern Half Dime, PR65 PCGS1871 H10C Half Dime, Judd-1062, Pollock-1197, R.7, PR65 PCGS. Longacre's Indian Princess design with Liberty seated and wearing an Indian headdress, one hand resting on a globe, the other holding a Liberty Pole, with conjoined flags behind. The reverse is the regular issue design for Liberty Seated half dimes. Struck in silver with a reeded edge. Rich antique-gold toning yields to cobalt-blue shadings around the devices and golden-orange iridescence toward the rims. Sharply struck with shimmering fields, this obviously original Gem is free of noticeable distractions. Population: 1 in 65, there are none finer (10/02).
From the Harold Hoogasian Collection. (PCGS# 61321)
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AgriPOWERs second class in session
Twenty-two Ohioans interested in becoming future leaders, advocates and activists for Ohio agriculture
Reporters, please visit our news room located in the Media and Publications section of this site.
Twenty-two Ohioans interested in becoming future leaders, advocates and activists for Ohio agriculture
We want to ensure that agritourism enterprises are not stifled by rules or laws, confusion about how these businesses operate or any other issues. Here are three concerns we commonly hear. What other concerns and problems do you face?
OFBF is continuing to explore ways it can work with the scrap metal industry and local law enforcement to address farmers concerns over metal theft.
If nothing else, the nations ongoing discussion about food production has revealed the complexity of issues relating to economic, environmental and social sustainability.
The purchase includes five IDEAg branded farm shows Minnesota Farmfest, Dakotafest, Amarillo Farm and Ranch Show, Northern Illinois Farm Show and the IDEAg Interconnectivity Conference. The business also publishes Feed & Grain Magazine and Case IHs Farm Forum magazine.


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Live Whitney Houston CD/DVD to be Released Nov. 11
Posted: 09/16/2014 - A CD/DVD featuring Whitney Houston's first public performance — and her last one in 2012 — will be released Nov. 11.
Posted: 09/16/2014 - A CD/DVD featuring Whitney Houston's first public performance — and her last one in 2012 — will be released Nov. 11.
Posted: 09/15/2014 - Oscar Pistorius is free to compete for South Africa again, as long as his running doesn't go against the ruling of the judge.
Posted: 09/15/2014 - Emily Younker isn't getting married until next year but she's already made sure the date doesn't conflict with college football and sent one invitation: To Big Al, the elephant mascot of the University of Alabama Crimson Tide.
Posted: 09/15/2014 - The calls to 911 raised an instant alarm: One caller said he shot his co-workers at a Colorado video game company and had hostages. Another in Florida said her father was drunk, wielding a machine gun and threatening their family.
Posted: 09/15/2014 - Miss New York Kira Kazantsev won the Miss America pageant Sunday night, with the help of a red plastic cup.
Updated: 09/15/2014 - J.J. Watt caught a 1-yard touchdown pass, Arian Foster ran for 138 yards and a score and the Houston Texans won their second straight game to open the season, beating the Oakland Raiders 30-14 Sunday.
Posted: 09/15/2014 - Johnny Manziel has made his NFL regular-season debut, coming off the bench for the Cleveland Browns in the third quarter Sunday against New Orleans.
Posted: 09/12/2014 - Johnny Manziel felt as if he was watching himself.
Posted: 09/12/2014 - An Australian DJ who made a hoax call to a hospital caring for the Duchess of Cambridge has tearfully apologized to the family of a nurse who committed suicide after the broadcast.
Posted: 09/12/2014 - This year's Toronto International Film Festival belonged to the actors.
Posted: 09/10/2014 - Everything about U2's new album is unexpected. Like its very existence, for one, after the Irish rock band dropped it on iTunes users Tuesday in a surprise move.
Posted: 09/10/2014 - Nicki Minaj, who has recently dropped her colorful and oddball style for a more natural and sophisticated look, says it's because she's more comfortable in her skin.
Updated: 09/10/2014 - Serena Williams was in the middle of settling down for an interview when she was interrupted by a message: "Anna is here."
Posted: 09/10/2014 - Getting a family of six out the door on time can be quite a challenge — even when you're a Beckham.
Posted: 09/09/2014 - Gerald Wilson, the dynamic jazz big band leader, composer and arranger whose career spanned more than 75 years, has died. He was 96.
Posted: 09/09/2014 - The Baltimore Ravens have released Ray Rice and the NFL has suspended the running back indefinitely over a domestic violence episode at an Atlantic City casino in February.
Posted: 09/08/2014 - As New York Fashion Week passed the midway point, Monday was expected to bring spectacle, celebrity and style.
Updated: 09/08/2014 - Prosecutors said Monday they have dropped an assault charge against Canadian pop star Justin Bieber in connection with an incident involving a Toronto limousine driver.
Posted: 09/08/2014 - British actor James Corden will replace Craig Ferguson as host of "The Late Late Show" on CBS next year, part of a complete overhaul of the network's late-night talk show lineup put in motion by the impending retirement of David Letterman.
Posted: 09/08/2014 - Howard Stern delivered the eulogy, Broadway singer-actress Audra McDonald sang "Smile" and bagpipers played "New York, New York" at Joan Rivers' funeral Sunday, a star-studded send-off that — like the late comedian herself — brought together the worlds of Hollywood, theater, fashion and media.
Posted: 09/08/2014 - The Governator is back.
Updated: 09/08/2014 - The Duchess of Cambridge, wife of Prince William, is expecting her second child and was being treated for severe morning sickness, royal officials said Monday.
Posted: 09/05/2014 - On "The Ed Sullivan Show" in 1967, Joan Rivers joked about society's double-standard for women.
Posted: 09/05/2014 - Americans' obsession with jeans is beginning to wear thin.
Posted: 09/04/2014 - NEW YORK (AP) - Comedian Joan Rivers has died, says her daughter Melissa Rivers.


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COLUMBIA, S.C. — Down and dirty is how politics is played here. Always has been. Maybe always will be.
In the final days before Saturday's Republican primary, the GOP presidential candidates are simultaneously launching grenades at each other and trying to duck missiles hurled at them by outside groups.
Traditional whispers and winks take a back seat to push polls, fliers on car windshields, anonymous phone calls, e-mails, mailers, websites and even critics who show up at candidate events.
Politics of destruction
None of this comes as a surprise in a state that produced Lee Atwater, a strategist for George H.W. Bush's campaign who helped mastermind the infamous Willie Horton ad.
Caucus-Goers WantedAre you planning to caucus Feb. 5? Are you an unaffiliated, but politically active voter who wishes you had a say in winnowing the presidential field? Either way, we'd like to hear from you. We're looking for men and women of all political stripes to profile in upcoming stories about election excitement.
- Send us an email.
But the question this year is whether there's enough time to do real damage. The front-loaded primary schedule left the top candidates — separated by only a few percentage points in recent polls — with only a few days to campaign in South Carolina.
"Our primaries are often politics of personal destruction here," said South Carolina GOP chair Katon Dawson. "I'm not sure though there's enough time for the tactics to work. But it could, especially with the candidates bunched so closely together."
Some voters say the negative messages work, and others say they have no effect, especially for those who have already decided on a candidate.
"We see it all the time here. I think it probably works for those who are on the fence.
Laurie Chapman, a 48-year-old stay-at-home mom from Little Mountain, said she doesn't see anything wrong with a little negativity and mudslinging.
"Voters need to know what's going on," said Chapman, who is undecided but leaning toward Mitt Romney.
Alienation a risk
In a primary, however, candidates and groups supporting them walk a fine line between trying to garner support and alienating voters.
"For undecided voters, negativity can sway them a little one way or another. But push polls and attacks also can turn people off. It solidifies their support for someone else or makes people say, 'I'm not voting for that person,' " said Dave Wilson, a strategist with the Lexington communications firm Inspired Hype.
For instance, Susan Bishop, a retiree from Newberry, said she's received a number of phone calls from campaigns and what she believes was a push poll. She doesn't like it.
"It doesn't sway me at all. When I make up my mind, I get going," said Bishop, who is backing Fred Thompson, a former Tennessee senator. "I do think all those calls turn people off to the whole process."
In recent days, some of the most hard-hitting attacks have come from independent political groups.
A victims group aired a TV ad against Mike Huckabee, showcasing the mother of a woman who was raped and killed by a convict paroled by Huckabee when he was governor of Arkansas.
John McCain has been targeted by a group called Vietnam Veterans against John McCain, which accuses him of abandoning other prisoners of war in Vietnam.
A group supporting Huckabee called Common Sense Issues, a nonprofit political organization based in Colorado Springs, is conducting push polls that criticize the other candidates. Huckabee asked the group to stop, but it refused.
Who will emerge as the GOP nominee is anyone's guess. Initially, South Carolina had 47 GOP delegates, but after the state moved up its primary, national officials stripped it of 23 delegates. Since 1980, the Republican candidate who won the Palmetto State has gone on to be the nominee.
The chaos of the GOP race, however, has officials wrestling with the notion that a nominee may not be picked until the party's convention in September.
Karen E. Crummy: 303-954-1594 or firstname.lastname@example.com


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The American Heritage Girls....The Conservative alternative to the progressive femi-nazi Girl Scouts...Promoting Christian and Family Values
Abdul Jalib • 1 year ago
The labels are a result of the adjectives you use to describe yourself and the fact that I debate progressives such as yourself on a daily basis.. Any pornography on my boards is a result of morally bankrupt individuals such as yourself hacking my account. Thank You for pointing it out and I have removed what I have found. While you love to use the term paranoia, the accusations made were confirmed by the CEO of the GSA. Instead of attacking me why don't you own up to your desire to justify your own immoral behavior by posting on Andi's pin in the first place? I don't dislike you personally, I am not angry or paranoid, I feel sorry for you that you have to lie to yourself to stomach the life you must have that you needed to post in the first place.
Natalie T • 1 year ago
Your account was hacked. Right. I'm seeing more proof that you need help, dude. I'm morally bankrupt? No, I have very good morals and I don't need the threat of some boogeyman to keep me in line. I found this pin from a link in an article I was reading and wanted to clear up some misconceptions but as the saying goes, you can't wake someone who's pretending to be asleep.
Abdul Jalib • 1 year ago
My account has been hacked multiple times. Keep trolling. However, I did not mean to imply that I am without sin. With the gift of free will and our lack of perfection comes our sinful nature. We all sin. Christians are no different than any other fallen person. If any of us is attempting to "stay in line" then it is only through the grace of God that we do. God is Love. That is a definition of God that atheists refuse to accept as it simplifies God to a description that they can no longer deny with the convoluted lies they tell themselves to justify their own sinful nature. Christians aren't trying to avoid sin to be better than others, but instead to leave a legacy of love to our posterity. Progressives and atheists justify their sin by claiming it is normal behavior. One action is propagates good and the other evil. The only misconceptions were the ones you had. I provided citations fo every accusation, while you provided only vitriolic attacks.


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Hopefully Dusty reads RZ. I think it's time.
Hopefully Dusty reads RZ. I think it's time.
The curious case of Chris Heisey...
CareerCode:Split G GS PA AB R H 2B 3B HR RBI SB CS BB SO BA OBP SLG OPS TB GDP HBP SH SF IBB ROE BAbip tOPS+ Start 16 16 67 57 7 11 2 0 1 9 2 1 7 16 .193 .299 .281 .579 16 0 2 0 1 0 2 .244 53 65 Sub 40 0 49 44 9 17 1 0 3 12 1 0 3 11 .386 .408 .614 1.022 27 0 0 0 2 1 0 .438 162 221
I really don't know what to make out of this. I think that Hesiey is likely a .770-.800 bat going forward, but these splits are pretty intense.Code:Split G GS PA AB R H 2B 3B HR RBI SB CS BB SO BA OBP SLG OPS TB GDP HBP SH SF IBB ROE BAbip tOPS+ Start 58 58 242 214 31 47 10 0 5 22 3 3 18 62 .220 .299 .336 .635 72 2 7 1 2 1 4 .282 68 Sub 95 0 100 88 18 32 3 1 7 20 1 0 8 22 .364 .410 .659 1.069 58 1 1 0 3 1 0 .403 177
In the interest of full disclosure, I have to add this: I'm not a big fan of any of the LF options, beyond "who's hot lately" or "who has a good matchup today." I think that LF is a key place to make a large-scope improvement, but I'm not sure if Heisey is or is not the answer.
I for one would like to see Heisey start about 10 games in a row, just to see what happens.
One thing to note on his career splits are the babip numbers.
I for one have always been jazzed about the idea of a Heisey-Stubbs-Bruce OF going forward. Not sure why more people aren't with me on that. Or maybe they are and I'm just neurotic.
"Ill kind of have a foot on the back of my own butt. Thats just how I do things. -- Bryan Price, 10/22/2013
Heisey -- Stubbs -- Bruce....that outfield is pretty impressive defensively
For Love of the Game
"If you aren't first; you're last"
Heisey is the new Denorfia. Low draft pick, good minor league record. Runs well (better %than stubbs in minors), plays good D and has some pop.
Like Deno, he has some staunch supporters and detractors and never could get the FO or manager to believe in him.
Deno has performed well when healthy (.766 OPS career .805 this year). His problem has been staying healthy.
Heisey (and previoulsy Deno) would be fine by me.
"A person is smart. People are dumb, panicky, dangerous animals and you know it."
Heisey of the three choices for left is the best one. But I'm afraid if he played every day that his warts would show. To me he just looks like a 4th outfielder. Like Oneupper said he another Denorfia with maybe just a little more power.
Reds Fan Since 1971
I have been wanting him to get a shot all year. Maybe this is it. He's going to have to get hot I think for Dusty to play him. There is a love for Gomes so it will be hard for any long term full time position, but as long as he takes the other LF starts I'm excited.
And This One Belongs to the REDS!!!
I agree with others that Heisy's ceiling is probably as a very good 4th OF'er, buy "probably" is the key word there. We know for sure what we have in Gomes and Lewis, the only way we find out for sure about Heisy is consistent starts. Considering the other two are underwhelming, now is the perfect time for Heisy to get a legitimate look.
I'd like the Reds to get a legit LF with Heisey as the fourth outfielder. He'd still get plenty of playing time.
With Stubbs striking out in epic proportions these days, I think we'll see Heisey play some CF soon. Stubbs needs a rest IMO.
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Murphy, J; Taylor, P; Darlison, MW; Ingram, D; (2003) The CHIME Graduate Programme in Health Informatics. In: Proceedings of the IMIA Working Group on Education Conference. (pp. 1 - 6). Oregon Health & Science University and WG1 IMIA: Portland, Oregon.
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23-25 April 2003 In 1999, University College London inaugurated a programme of graduate part-time Health Informatics courses to support the UK National Health Service's information strategy (Information for Health). The programme has attracted students from across the UK and abroad, with a diverse range of backgrounds and skills, and has proved a challenging and rewrding experience for students and tutors alike. The modular programme aims to provide a thorough grounding in the theory and practice of Health Informatics and addresses important application areas. As we move towards our fifth intake of students, we are in the process of evaluating our programme and carrying out a follow-up study of our graduates to see how the experience has impacted on their career development and their professional practice.
|Proceedings paper
|The CHIME Graduate Programme in Health Informatics
|Teach Globally, Learn Locally: Innovations in Health and Biomedical Informatics Education in the 21st Century
|2003-04-23 - 2003-04-25
|Open access status:
|An open access version is available from UCL Discovery
|Additional information:
|Conference Proceedings published on a CD Rom
|Curriculum Issues, Health Informatics Education, Programme Design
|UCL classification:
|UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > CHIME
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text: COVER BY: SIMONE BIANCHI WRITER: DANIEL WAY PENCILS: STEVE DILLON INKS: STEVE DILLON COLORED BY: AVALON - MATT MILLA LETTERED BY: VC - CORY PETIT THE STORY: "THE DEEP END" Wolverine just will not #$%ing die! Now, this is really no big surprise to Deadpool, but it is definitely...frustrating. Maddening, in fact. Will Deadpool be able to keep it together long enough to pull the trigger on his "master plan?" Or will he, instead, be the one who gets trapped? After all, it's not like this is Wolverine's first time around the block…Part 3 of 5. Parental Advisory …$2.99 IN STORES: March 19, 2008


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
34 year old man | Lincoln, NE, USA | Seeking women 25-35 within 50 miles
Quirky-nerdy nice-guy looking for whip-smart Renaissance Womanl
Well, then: Hello. I'm new to Lincoln. Just moved here to start my shiny new life as a professor. I'm pretty gosh-darn stoked about this. Only problem is, being new to Lincoln, that I know no one in these parts. So, here I am, looking for friends, including friends with the potential to become more. Me in a nutshell: I'm a somewhat quirky, goofy, slightly nerdy academic type. I love the smell of books, and get a huge rush pulling back-to-back all-nighters to get an article ready for publication. I'm also an outdoorsy type: I enjoy camping and rock climbing, and am looking forward to taking advantage of our relative (to the east coast) proximity to Colorado. I also dance Argentine Tango -- I've been doing that for more than a decade now, and have danced in six countries. I'm very independent, and generally get along best with similarly-minded women. Relationship-wise, I'm looking for someone who wants to share part of the incredible life she's made for herself, and with whom I can do the same. Someone who's got her own thing going on, about which she's unyieldingly passionate about. Someone who has a brilliant head screwn squarely onto her shoulders. Someone who wants to occasionally hop in a car or plane to head off into the sunset for a while. Generally, I guess that kind of sums me up. I'm really passionate about a few things, and really curious about other things. I love not knowing things, and hanging out with folks who know things that I don't know. I try not to sweat the little stuff -- actually, I rather enjoy the little flaws and mistakes we run into (or make) in our day-to-day lives -- they're a nice reminder that imperfection is ok and inducement to grow.
Camping , Coffee and conversation , Cooking , Dining out , Museums and art , Exploring new areas , Playing cards , Political interests
Cycling, Dancing, Other types of exercise, Walking / Hiking
I exercise 3-4 times per week.
I have Cats
I like Dogs
True story: a parrot tried to kill me when I was an infant. Despite this, I like birds.
Middle of the Road
Slowly learning places in Lincoln: Jake's; Sunken Gardens; the bike trails. Outside of Lincoln: Seneca Rocks, WV; the Gunks, NY; Washington, DC; my classroom; coffee shops; Buenos Aires.
Pincites in footnotes and small caps typefaces, hyphens and dashes in their proper places, dozens of sources, all cited in strings, these are a few of my favorite things. Breezes on a mountain's top; and shade at its bottom.
Rock climbing, dancing, riding ye olde bike, camping, hiking, reading, cooking, drinking yummy yummy beer (or wine!).
I read and write for a living ...
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'8" (172cms)
|5'0" (152cms) to 5'10" (177cms)
|Body type:
|About average
|Slender, About average, Curvy, Athletic and toned
|No preference
|Light brown
|No preference
|No Way
|No Way, Occasionally, Cigar aficionado
|Social Drinker
|Social Drinker
|Education / Teacher / Professor
|No preference
|I'll tell you later
|No preference
|Never Married
|Never Married, Divorced
|Have kids:
|Wants kids:
|Definitely, Someday, Not sure
|White / Caucasian
|No preference
|Agnostic, Atheist, Jewish, Spiritual but not religious, Christian / Other
I am open minded about religion, and get along with most folks who have struggled to define, and remain able to question, what they believe.
|No preference
|PhD / Post Doctoral
|Bachelors degree, Graduate degree, PhD / Post Doctoral
I've got a few degrees. Yeah, I'm kind of a big deal. Or something. I drink scotch, too.


text:
Bon Appétit
November 2006
reviews (12)
make it again
Photo by Mark Thomas
Makes 6 servings
Prepare perfect mashed potatoes
(but do not add milk). Whisk sour cream, chopped chives, and horseradish in medium bowl. Fold sour cream mixture into potatoes. Season with salt.
Very delicious and easy. I used only 1 Tbsp of butter instead of 3 Tbsp and it was fine. I'm sure it would have been even more delicious with 3 Tbsp but still great. I will definitely be making this again.


text:
- Studio: York Entertainment
- Release Date: Sep 26, 2003
- Summary: A psychological thriller about an LAPD crime scene photographer who tries to confront his fears by setting his own boundaries on reality and illusion. (Fish Eye Films LLC)
- Director: Hamlet Sarkissian
- Genre(s): Drama, Thriller, Crime
- More Details and Credits »
Score distribution:
Positive: 1 out of 5
Mixed: 3 out of 5
Negative: 1 out of 5
More "Heat" than "Eraserhead". It's all good. Just don't be disappointed if it's not what you were expecting. Try to enjoy this for what it is.
The promise of a stylish psychological thriller is squandered in Camera Obscura, which lapses into an ordinary, wearying tale of a nice guy in over his head with ruthless criminals.
Unable to blend artfilm with psychological thriller, writer-director Hamlet Sarkissian makes something opaque indeed out of Camera Obscura.
Sarkissian's script is both overwrought and undercooked, crammed with floridly senseless speeches.