text:
Results from Study TKT032 in Adults and Children
TKT032 was a 12-month, randomized, double-blind, parallel-group global study in 25 treatment-naive patients aged two years and older that evaluated velaglucerase alfa at 45 U/kg and velaglucerase alfa at 60 U/kg. Patients were eligible to participate in the study if they presented with disease-related anemia and had at least one of the following clinical manifestations of Gaucher disease: thrombocytopenia, moderate splenomegaly or a readily palpable enlarged liver.
The primary endpoint was change in hemoglobin concentrations from baseline at 60 U/kg. Secondary endpoints for both doses were changes in platelet counts, changes in organ volumes, changes in surrogate markers of Gaucher disease, and for the 45 U/kg dose only, change in hemoglobin concentrations from baseline.
At 12 months, in the 60 U/kg group, statistically significant changes in mean hemoglobin concentration increased 23.3%, +2.43+/-0.32 g/dL, P< 0.0001; mean platelet count increased 65.9%, +50.9+/-12.2x10(9)/L, P=0.0016; and mean spleen volume decreased 50%, -1.92+/-0.51% body weight, P=0.0032, from 14.0 multiples of normal [MN] at baseline to 5.75 MN. Mean liver volume decreased 17%, -0.84+/-0.33% body weight, P=0.0282, from 1.46 to 1.22 MN.
Results for 45 U/kg were consistent with those observed with 60 U/kg; however a dose-related effect in favor of velaglucerase alfa at 60 U/kg was observed by platelet count increase and liver volume reduction between the 2 dose groups.
Adverse events
|SOURCE Shire plc
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text: > View Product Details Please select the size of the product. Please enter valid quantity. Gucci light brown cotton twill two button notched lape blazer overview details Retail: $1,750.00 Reduced: $890.99 20% Off : $712.79 color : We're sorry. This style is currently unavailable. Light Brown Saddle up for amazing equestrian influenced designs from the venerated Italian fashion house of Gucci. Color: Light Brown Mid-weight cotton twill Notched lapel Two button closure Decorative five button cuff Three front pockets Rear center vent Partial lining with two inner pockets Modern fit Self: 100% Cotton; Lining: 100% Cupro; Dry Clean; Imported; style#319154601

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text:
Mastronics Ltd
- Address:
- 61-63 Wellington Road North
- Postcode/City:
- SK4 1HS Stockport
- County:
- Greater Manchester
Updated more than 6 months ago | Claim This Business| Report Incorrect Data
Detailed Business Information
- Official Name
- Company Number
- 6848122
- SIC Code
- 47520 - Retail sale of hardware, paints and glass in specialised stores
47540 - Retail sale of electrical household appliances in specialised stores
- Date of Incorporation
- 16/03/2009
- Company Type
- Private Limited Company
Quest Slimline Wall Heater
Carriages Haywards Heath, 04 March 2014
2 panels ordered, one didn't work. Contacted Mastronics, not a problem, "send it back and we will replace it". One month on still waiting, no reply to e-mail and No answer to phone, voice mail box full. GONE OUT OF BUSINESS??
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Sink cleaner
16 December 2013
Have just received my order. Both bottles of 'shiny sink' have arrived with BOTH tops broken! Badly packed. Wouldn't buy anything else from you.
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text:
Junior Summer Theatre Conservatory
CTC's popular Junior Summer Theatre Conservatory is a two-week, half-day program designed to introduce the concept of making plays. In this active, nurturing environment, the students, led by CTC's professional theatre educators, will engage in theatre games & activities, create crafts, and rehearse a short play. Family and friends are invited to a presentation on the final day which will showcase a sampling of favorite warm-ups, games & exercises, and a short play.
- Ages 5-8 (Must be age 5 by January 1, 2015)
- Half-day program (9:00 a.m.-12:00 p.m.) on Tuesdays – Fridays (8 days)
- Held at the CTC Classroom (753 E El Camino Real, Sunnyvale)
- Introduction to concepts of drama playmaking
- Active and nurturing environment
- Taught by professional CTC theatre educators
- Presentation for family and friends on final day
Register and pay in full by February 28 – just $330!
Tuition after February 28 – $370
Plus, if you are a CTC Playwright Circle Member for 2015-2016 (at $300 level or above), take an additional $25 off! (Not a CTC Member yet? Become one today by making a tax-deductible donation to support CTC's non-profit mission. Learn More!)
Refund Policy: Of your payment, $150 is a deposit which is non-refundable. If the student withdraws before Conservatory begins, CTC deducts the $150 deposit and refunds the remainder. If the student withdraws after Conservatory begins, CTC deducts the $150 deposit plus 10% of the balance for each day the student has attended the Conservatory and refunds the remainder.
Unsure if Junior Summer Theatre Conservatory is a good fit for your child?
Get a taste of the experience with one of our Saturday Morning or School Break
Theatre FunShops !
Our Education Department staff is also always happy to discuss your child's individual needs and interests and to recommend programs accordingly.
Junior Summer Theatre Conservatory 2015
Dates and Locations
Session 1:
Tuesday, June 16 – Friday, June 26 FULL – NOW TAKING WAITLIST
9:00am – 12:00pm
CTC Classroom in Sunnyvale
Session 2:
Tuesday, July 7 – Friday, July 17
9:00am – 12:00pm
CTC Classroom in Sunnyvale
Mail, fax or email the Conservatory Registration Form to our office.
or call 408-245-2979 to register by phone.