text:
Apparatus, systems and methods are disclosed for treating a biological fluid with light. A disposable fluid processing set including integrally connected containers and tubing and a holder or organizer for receiving at least some of the containers and tubing are disclosed.
1. A pre-packaged medical product comprising:
a fluid processing set including at least two flexible containers integrally connected by a flexible plastic tube;
a support, separately provided from said processing set, wherein said support comprises a folded sheet of flexible material comprising inner facing surfaces and an outer surface when folded and wherein at least a portion of said outer surface provides a substantially rounded surface; and
wherein at least one of said containers is folded over said outer surface.
2. The product of
3. The product of
4. The product of
5. A pre-packaged medical product comprising:
a fluid processing set including at least two flexible containers integrally connected by a flexible plastic tube;
a support separately provided from said processing set wherein said support comprises a folded sheet of flexible material comprising inner facing surfaces and an outer surface when folded and wherein at least a portion of said outer surface provides a substantially rounded surface; and
wherein at least one of said containers is folded over said outer surface and wherein said support comprises a tab for receiving a slit of a container folded over said support.
6. The product of
7. A pre-packaged medical product comprising:
a disposable fluid processing set including a first portion comprising at least one container and
a second portion comprising at least one container;
wherein said first and second portions are integrally connected by a plastic tube;
an organizer separately provided from said first and second portions for receiving at least one container of said second portion, said organizer comprising a folded sheet of a flexible material comprising inner facing surfaces and an outer surface when folded and wherein at least a portion of said outer surface provides a substantially rounded surface wherein at least one container of said second portion is folded over said outer surface; and
wherein the inner facing surfaces are maintained in a facing arrangement relative to each other by interlocking tabs and slots.
8. The product of
9. The product of
10. The product of
11. The product of
12. The product of
13. The product of
14. The product of
This is a continuation-in-part of U.S. patent application Ser. No. 09/325,599, filed Jun. 3, 1999, now U.S. Pat. No. 7,025,877.
The present invention generally relates to apparatus, systems and methods for processing and treating biological fluids, such as blood and blood components. More particularly, the present invention relates to disposable fluid processing sets used in the light-activated treatment of a biological fluid that contains a light activated photochemical agent, for the purpose of inactivating pathogens that may be present in such biological fluid. Even more particularly, the present invention relates to methods and apparatus for packaging and organizing the parts of the disposable fluid processing set in a way that makes the processing set easy to use by the end user.
Apparatus, methods and systems for treating biological fluids, such as blood and blood components, with light are well known. For example, U.S. Pat. No. 4,952,812, incorporated by reference herein, discloses an apparatus for treating unwanted white blood cells in platelet concentrate with ultraviolet radiation to limit the white cells' ability to trigger an immune reaction in a patient. To treat containers of platelet concentrate, the containers are placed on a slidable drawer that is introduced into a housing between facing arrays of lamps for irradiation from both sides of the container. During irradiation, the drawer (or a portion of the drawer) may be pivoted in a rocking motion to agitate the platelet concentrate.
U.S. Pat. No. 5,557,098, also incorporated by reference herein, discloses a system and apparatus for treating a biological fluid with light for the purpose of inactivating pathogens that may be present in the biological fluid. A slidable drawer is used to position the containers of biological fluid between facing arrays of light emitting diodes. Extended flaps on the containers, located outside the light field, are automatically punched to indicate different stages of the light treatment.
U.S. patent application Ser. No. 6,245,570, which is also incorporated by reference herein, discloses apparatus and methods for treating a container of a blood product between two facing arrays of light. The container includes a light sensitive tape which changes color when exposed to ultraviolet light, thereby indicating when the treatment process is complete.
Still other apparatus and systems for treating biological fluid are disclosed in U.S. Pat. No. 5,709,991, U.S. Pat. No. 6,190,609, and U.S. Pat. No. 6,433,343, all of which are incorporated by reference herein.
While the prior art apparatus, systems and methods have generally worked satisfactorily, efforts continue to develop new and improved apparatus, systems and methods that provide, for example, improved reliability, greater flexibility and efficiency, improved ease of use and serviceability, as well as enhanced tracking, record keeping and the like.
The following summary is intended as an overview of certain aspects of the present invention. It is not intended by this summary to limit or expand the scope of the claims, which define the scope of the present invention. The mention of certain features or elements in this summary does not mean that such elements or features are necessary to the use or practice of the invention in its broader or other aspects, or that such should be read into claims that do not expressly recite such feature or element. Conversely, the absence of any mention of certain elements or features is not intended to detract from the significance of such elements or feature in those claims in which they are expressly included.
In one aspect, the present invention is directed to a packaged fluid processing set that includes at least two flexible containers integrally connected by a flexible plastic tube. The packaged set includes at least one substantially rounded surface over which at least one of the containers is wrapped.
In another aspect, the present invention is directed to a disposable fluid processing set including a first portion and a second portion. The first portion includes at least one container. The second portion also includes at least one container. The two portions are integrally connected by a plastic tube. The set includes an organizer for receiving the second portion. The organizer is a folded sheet of a flexible material, wherein the facing sheet portions are secured to each other.
In another aspect, the present invention is directed to a disposable processing set that includes a first container including an inlet and an outlet and a treating agent within the container. The set includes a tube, with one end communicating with the inlet and defining an openable flow path. The set includes a second container and a tube, one end of which communicates with the first container and other end communicating with the second container and defining an openable flow path between the first and second containers.
In another aspect, the present invention is directed to a disposable processing set for treating a biological fluid that includes a first portion including a container for containing the biological fluid during treatment, a second portion including a container for receiving the biological fluid after treatment, and tubing connecting the containers and defining an openable flow path therebetween. The processing set includes a holder for temporarily holding the second portion separate from the first portion.
For purposes of illustration, the various aspects of the present invention will be described, in large part, in connection with their preferred embodiments. However, it should be recognized that the apparatus, systems and methods embodying the different aspects of the present invention are not limited to the specific details described herein.
An illumination device for treating a biological fluid is generally shown in
Light box 10 is particularly useful in the treatment of biological fluids. As used herein, biological fluid refers to any fluid that is found in or that may be introduced into the body including, but not limited to, blood and blood products. As used herein "blood product" refers to whole blood or a component of whole blood such as red blood cells, white blood cells, platelets, plasma or a combination of one or more of such components that have been separated from whole blood.
One specific, non-limiting use of light box 10 is in the treatment of a blood product that has been combined with a photochemical agent for activation when subjected to light. Such photochemical agents are used, for example, in the inactivation of viruses, bacteria, white blood cells and other contaminants (collectively referred to herein as "pathogens"). In pathogen inactivation applications, the activated agent inactivates pathogens that may be present in a blood product.
Typically, the biological fluid to be treated is introduced into a fluid treatment chamber within light box 10 in flexible, plastic, sterilizable, translucent, biologically compatible containers. In accordance with aspects of the present invention, the containers may be integrally connected to other containers and plastic tubing useful in the processing of the biological fluid both before and after the treatment provided by light box 10. Examples of the disposable processing set, its components and holders and/or organizers for such sets are shown in
a. Light Box
As shown in
For convenience and efficiency, it is preferred that light box 10 be fairly compact. In one, non-limiting example, light box 10 may be approximately 100 cm wide, 20-40 cm deep and between approximately 30-40 cm high. A compact instrument allows, for example, for placement of a greater number of instruments per treatment center and/or may allow two or more instruments to be stacked on top of each other (as shown in
Light box 10 may include a control module 26 and a fluid treatment module 28. As described in more detail below, control module 26 may include and/or house the command and control elements for the treatment of biological fluid. Fluid treatment module 28 houses the elements and components where fluid processing takes place.
Control module 26 and fluid treatment module 28 may be contained in the same housing but in a preferred embodiment, as shown in
Providing light box 10 in two readily separable modules 26 and 28 allows for easier access to the control and fluid treatment modules 26 and 28 and, generally, provides for easier serviceability of light box 10. For example, if off-site service is required for control module 26 only, that module can be removed without requiring removal and transport of the entire light box 10.
As shown in
The interior components of control module 26 are generally shown in
Control module 26 may be adapted for connection to external components such as a printer 500 (
Turning now to the fluid treatment module 28, as shown in
Returning to
As shown in
Turning more specifically to a description of fluid carrying drawer 50, as shown in
For ease of loading and unloading containers of biological fluid, fluid carrying drawer 50 preferably includes a pivot mount that permits the drawer to be tilted downwardly when fully withdrawn. The ability to tilt drawer 50 downwardly may be particularly useful for loading containers of fluid in the upper light boxes where two or more light boxes are stacked on top of each other, as shown in
To allow tilting of fluid carrying drawer, light box 10 may include spring loaded tilt knob 83 which, when pulled, releases fluid carrying drawer 50 and allows it to be tilted in the manner described above. More specifically, as shown in
As shown in
During treatment of the biological fluid, it may be desirable that the fluid within fluid carrying drawer 50 be continuously or periodically agitated to provide mixing of the biological fluid and ensure that substantially all of the biological fluid is sufficiently and uniformly exposed to light and/or any photochemical agent. Accordingly, fluid carrying drawer 50 may be attached to means for agitating the biological fluid.
As shown in
Light box 10 may include one or more light sources, preferably disposed above and below fluid treatment chamber 50. For ease of serviceability, such as lamp replacement, it is preferable that the light source(s) be readily accessible. As used herein, "readily accessible" means that access to the light source can be quickly and easily had without the use of, for example, a screwdriver or other tools. For example, in one embodiment, it may be desirable that the light source be either partially or completely removable from the housing 12 and/or fluid treatment module 28. The light source(s) may be accessible through any one of the front, side, top or bottom panels. In one embodiment, the light sources are housed in light drawers 60 and 70. As shown in
As shown in
Each of light chambers 101 and 103 of light drawer 60 or 70 is generally defined by four side walls 105 a-d and a bottom wall 107. Walls 105 a-d and 107 may be made of or coated with a reflective material to maximize the amount of light delivered to the biological fluid. In one specific embodiment, where the light source provides light in the ultraviolet A (UVA) range, walls 105 a-d and 107 may be made of a highly reflective aluminum to provide substantial reflection of UVA light. Such a material is sold under the name 1500 G-2 and is available from ALANOD of Ennepetal, Germany.
The light sources suitable for use in the present invention may include any light source that is capable of providing light of a particular wavelength and intensity for treating a particular biological fluid. For example, light sources capable of providing white light, red light, infrared, ultraviolet A and/or B light may be used. Light drawers 60 and 70 may include a single lamp or an array of multiple lamps 100. In one embodiment, light source may include standard fluorescent lamps or bulbs capable of providing light of a wavelength in the UVA (ultraviolet A) range. Such lamps may be obtained from Sankyo Denki of Japan under the product code BL352. Light drawers 60 and 70 may optionally include fans 109 for cooling lamps 100 and, more specifically, ends of lamps 100 at or near the lamp filaments.
As shown in
As shown in
As set forth above, fluid treatment module 28 may, optionally, include marker assembly 74. Marker assembly 74 may include one or more markers 76 a-76 d for marking containers within fluid treatment chamber. One or more markers 76 may be provided to mark containers at different stages of the treatment. Markers 76 a-d may be punches for punching holes into a portion of the container such as the container flap as described in U.S. Pat. No. 5,557,098, which is incorporated by reference. Alternatively, and more preferably, markers may be stampers for stamping designated portions of a container with ink. Such markers are commercially available from Trodat of Wels, Austria under the product name Printy 4911.
As shown in
As shown in
Fluid treatment module 28 includes blower 134 which provides air flow into fluid treatment chamber 40 and fluid containers and thus, provides for temperature control of fluid treatment chamber 40 (
Returning to the fluid treatment module 28 and more specifically fluid carrying drawer 50, as shown in
Where one or more containers are to be treated, tray 90 may be divided into a first portion 180 and a second portion 182 separated by dividing wall 184. As shown in
Where the biological container is part of an integrated fluid processing set, tray 90 may be compartmentalized to provide separate compartments for the container undergoing treatment on the one hand, and the remainder or a portion of the remainder of the disposable processing set, on the other hand. As shown for example, in
When the tray 90 with disposable processing set is introduced into fluid treatment chamber 50, container 206 within a first compartment 188 is positioned substantially within the field of light provided by the light source. The remainder of the disposable processing set and/or containers within a second compartment 190 is outside the field of light, preferably held in place by tray cover 380, described below. In the embodiment where marker assembly 74 is provided, containers within second compartment 190 are aligned substantially with marker assembly 74 as shown in
In an embodiment where the light box does not include a marker assembly, drawer 50 may include a cover 380 shown in
As shown in
Light box 10 may include sensors for detecting different conditions during the pretreatment and treatment process. The sensors relay signals to the microprocessor of the light box 10 which is housed within control module 26. As shown for example in
For example, light box 10 may include internal light intensity sensors 404 for measuring the intensity of light provided by the lamps 100 to fluid treatment chamber 50. In the event that the light intensity provided by lamps 100 is insufficient for the desired treatment, sensor 404 sends a signal through input/output board 170 (
In one embodiment, light intensity sensors 404 may be located within the light chambers 101 and 103 of light drawers 60 and 70 (
A fluid carrying drawer sensor 144 may be included for monitoring the position of fluid carrying drawer within fluid treatment chamber 40. Fluid carrying drawer positioning sensor 144 ensures that the drawer 50 is in a fully closed position and therefore, that containers of biological fluid are substantially within the field of light provided by lamps 100. If the drawer is not in a fully closed position, sensor 144 sends a signal to the microprocessor, alerting the operator and preventing treatment from proceeding.
Light box 10 may further include temperature sensors 145 for either directly or indirectly monitoring and measuring the temperature within fluid treatment chamber 40. Temperature sensor may be disposed within the fluid treatment chamber 40 or, as shown in
Additional sensors may be provided, including a sensor for monitoring the agitation provided by the agitation assembly. In one embodiment, sensor 430 may be attached to marker subassembly 74, as shown in
Light box 10 may also include a sensor 440 to detect whether the front door of the light box is closed during treatment. Door sensor may be a magnetic switch which detects contact between door 36 and magnetic plate 441 shown in
Light box 10 may also include sensors 450 for determining whether containers are present and/or in position for marking by markers 76. As shown in
In an embodiment where light box 10 does not include marker sub-assembly 74, the LEDs are located above compartments 190, aligned with apertures 384 in cover 380. Light from LEDS passes through apertures 384 in cover 380. Sensors 450 are aligned with the LEDs. As described above, if sensor receives the signal from the LED, this indicates that no container is present and the instrument will either alert the operator or terminate further processing.
In addition, a portable and attachable light intensity sensing, verification and calibration device or radiometer 460 may be provided to verify light intensity provided by light box 10 and for calibration of light box 10. Radiometer 460 may be adapted for placement within fluid treatment chamber 40 for measuring the energy dose delivered to the biological fluid. More specifically, radiometer 460 may be adapted for placement within the fluid container-carrying tray 90. In one embodiment, radiometer 460 may be adapted for placement within a compartment of tray 90 such as first compartment 188 of tray 90.
As shown in
It is known that a light source may not always uniformly emit light. For example, depending on the age of the lamp, the intensity of light emitted from one part of the lamp may not be the same as the intensity emitted from another part of the lamp. Accordingly, in a preferred embodiment, as shown in
An electrical cord (not shown) is attached to radiometer 460 for electrical connection to light box 10 and, for example, port 461 (
Sensors 469 may typically be photodiodes capable of detecting light of selected wavelengths. Sensors 469 may also include or be used with filters to filter out unwanted light as substantially described above.
When used in connection with light box 10, it is preferred that the dimensions of radiometer 460 be substantially equivalent to the dimensions of the fluid-filled containers used with light box 10. Accordingly, it is preferred that the light sensing area of radiometer 460 have a height, a width and a thickness substantially equal to such filled containers. A radiometer with dimensions substantially equal to the fluid-filled container provides a reliable approximation of the energy being delivered to the fluid and of the effectiveness of the treatment.
As set forth above, radiometer 460 may be used for light intensity verification by, for example, the operator and for calibration of light box 10 generally and more specifically, of internal sensors 404. In accordance with the method of using radiometer 460 for light intensity verification, the operator may place radiometer 460 in first compartment 188 of tray 90. Cord may be pressed into strain relief tabs 474 within light box 10 (
Thus, for example if the energy dose measured by radiometer 460 is substantially equal to the energy dose detected by sensors 404, but is outside the pre-set dose range, this may be an indication that the output of lamps 100 has diminished and that lamps 100 may have to be replaced. Alternatively, if the energy dose as measured by radiometer 460 is substantially equal to the expected pre-set dose of the instrument, but both are different from the energy dose as measured by sensors 404, this may be an indication that sensing capability of sensors 404 has diminished. Finally, if the dose as measured by sensors 404 is substantially equal to the expected pre-set dose, but different than the energy dose as measured by radiometer 460, this may indicate that the sensing capability of radiometer 460 has diminished. Radiometer may also be used to calibrate light box 10. Radiometer 460 itself may be calibrated against a standard (e.g. a standard from the National Institute for Standards and Technology or NIST).
Of course, it will be appreciated that radiometer 460 may have utility in other applications and is not limited to use in the apparatus or methods of the present invention. Indeed, radiometer 460 may be used whenever light is to be measured over an extended surface area.
In one embodiment, the components of the fluid treatment module 28 including the agitator assembly, the light sources, the blower, and the marker subassembly are powered by power supplies as shown in
Finally, light box 10 includes a programmable computer software-based control system to control the operation of light box. The control system is generally and diagrammatically depicted in
Modifications and alternatives to the features of light box 10, including the electrical interconnections, sensing systems, mechanical components, and the method of treating a biological fluid are also described in the U.S. Patent Application entitled "Apparatus, Systems and Methods for Processing and Treating a Biological Fluid With Light," bearing Attorney Docket No. F8-5459 CIP, filed Oct. 11, 2002, previously incorporated by reference.
b. Disposable Processing Set
Disposable processing sets useful with light box 10 are generally shown in
One embodiment of a disposable fluid processing set 200 is shown in
Where the disposable processing set is used in or as part of a pathogen inactivation treatment, container 202 may include, for example, a treating agent such as a photochemical agent which is mixed with the biological fluid. Examples of such photochemical agents include psoralen compounds described in U.S. Pat. No. 5,709,991 and compounds from the family of phenothiazine dyes such as, but not limited to, methylene blue. Another example of a suitable agent is riboflavin. Container 202 may be made of any material suitable for holding such photochemical agents. One such material may be a blend of ethylene polypropylene, polyamide and a block copolymer of ethylene and butylene with terminal blocks of polystyrene. Containers made of such material are available from Baxter Healthcare Corporation under the name PL-2411. Container 202 includes a tubing segment 203 extending therefrom and having a sealed end 204. A second tubing 205 extending from container 202 is integrally connected to container 206. In another embodiment, the photochemical agent may be contained or predisposed within container 206, thereby eliminating the need for a separate container 202 for holding the photochemical agent. In still another embodiment, the photochemical agent may be combined with the biological fluid prior to joinder to the disposable processing set. For example, the photochemical agent may be included in a container 201 used to hold the biological fluid collected from a donor (
Container 206 is preferably a container suitable for holding the biological fluid during light treatment. Accordingly, it is desirable that container 206 be made of a clear, durable, thermoplastic material that is translucent to light of the selected wavelength and sterilizable by known forms of sterilization including steam sterilization, gamma and electron beam radiation. For example, where the blood product to be treated includes blood platelets or blood plasma and the treatment is to be with light in the UVA range, container is made of a material that is substantially translucent to UVA light and remains stable after sterilization. Such materials may include polyvinyl chloride, but more preferably, may be blends of thermoplastic polymers and copolymers, including general purpose polymers, elastomers and the like. One such material includes the block copolymer described above which includes a central block of ethylene and butylene and terminal blocks of polystyrene. Block copolymers of the type described above are available from the Shell Chemical Company under the name KRATON. The block copolymer may be blended with other polymers such as ultra low density polyethylene (ULDPE) and ethylene vinyl acetate (EVA). Containers made of the blended material are available from Baxter Healthcare Corporation of Deerfield, Illinois under the name PL-2410. Other thermoplastic materials may also be suitable for container 206, including materials including KRATON, EVA, and polypropylene. A container made from such material is also available from Baxter Healthcare Corporation under the name PL-732. Still other suitable materials for container 206 include fluoropolymers such as polytetrafluoroethylene (PTFE), PFA or copolymers including such fluoropolymers.
Container 206 further includes a slit 207 which, as described above, may be placed over retaining tab 186 in tray 90. Container 206 includes a tubing segment 208 which may be integrally connected to a container 210.
In the pathogen inactivation of biological fluid, container 210 may, for example, include an adsorbent material 211 for removing excess photochemical agent or the byproducts of the photoactivation process. The adsorbent material may be contained in a semi-permeable pouch, affixed to the container walls or portions thereof within the interior chamber of container 210 or, as shown in
Container 210 may also include a time-sensitive tape 209. Tape 209 changes color with time, thus informing the operator if the biological fluid has contacted the adsorbent material for a sufficient period of time.
Container 210 may be integrally connected by tubing segment 211 to another container 214 which may be suitable for storage of the biological fluid. As shown in
More preferably, the capturing device may be located in the flow path ("in-line") of tubing 211, between container 214 and the outlet port of container 210, as shown in
Interior chamber 219 (shown in
The interior surface of at least one of walls 223 or 235 may be contoured. A contoured interior surface reduces the likelihood that filter element 221 will stick to the interior surface of the pouch wall. In one embodiment, the interior surface of one or both of walls 223 and 225 includes a plurality of ribs 223 that, as seen in
Where capturing device 211 a is a pouch of the type shown in
Container 214 may include and/or be capable of receiving a label 216 which may carry bar codes 222 or other indicia which provide information about the biological fluid. For example, bar codes 222 may identify the donor, the product, the lot number of the biological fluid, expiration date and the like. Container 214 may include additional bar codes or indicia 224 which are used to provide information regarding the status or progress of the fluid treatment (described in more detail below). Container 214 may also include a slit 226 and/or apertures 228, 230 for placement over corresponding pegs (193) on tray 90. Materials such as those described above are suitable for use in container 214. Container 214 may also include one or more sampling pouches 214 a and access ports 214 b to allow for fluid access during later transfusion, as will be recoginzed by those of ordinary skill.
In an alternative embodiment, disposable processing set may include a single container for housing the adsorbent material of container 210 and for storing the biological fluid, thereby combining the functions of container 210 and 214 described above.
The disposable processing set 200 described herein may further include frangible members 230(a-c) disposed within tubing segments as shown in
Another embodiment of a fluid processing set is shown in
In contrast to the container 210 of the earlier described embodiment, container 246 is a flow through device which includes adsorbent material 212 but does not include a chamber for holding the biological fluid for any significant period of time. Such flow through devices are described in International Publication No. WO 96/40857 which is incorporated by reference herein. Disposable processing set 240 may optionally include an air reservoir 256 and air sink 258. Air reservoir 256 provides air to help expel biological fluid from container 244 and air sink 258 receives excess air expelled from storage container 248 after processing. Air reservoir 256 and air sink 258 may be made of any suitable biocompatible material, including the materials described above. Likewise, the containers of disposable processing set 240 may also be made from the materials generally described above. Preferably, container 256 is substantially impermeable to air.
As in the embodiment of
Disposable processing set 200 (or 240) is typically provided to the user in a sealed package in a manner that is easy for the user to unpack and use. For example, upon opening the package, it is preferred that the container to be used first in the fluid processing be located near the top of the package. For example, in the processing set 200 shown in
As shown in
In one specific, non-limiting embodiment, sheets 412 and 414 may be single sheets or a laminate of, for example, two sheets of polypropylene with a printed dye on one of the sheets. For example, one sheet of the laminate may be an oriented polypropylene while the other (e.g., inner) sheet of the laminate may be cast polypropylene. A poly AZO-type pigment or any other suitable pigment may be printed on one sheet (such as the oriented polypropylene sheet) of the laminate. Laminated sheets of the type described above are available from Hosokawa Yoko Co. of Tokyo, Japan.
The total thickness of sheets 412 or 414 (whether or not laminated) may be any thickness required to provide sufficient light blockage and protection against ozone. In one embodiment, the thickness may be between approximately 35-65 microns and more preferably approximately 50 microns.
Container 202 may be constructed by integrally sealing together the four outer (412, 414) and interior (416, 418) sheets at seal lines 419. Openings are provided for insertion of inlet and outlet tubes 420 and 422. After insertion of tubes 420 and 422, the open areas are sealed (by, for example, RF heat sealing) to provide a completely sealed 4-layered container. It will be understood that outlet tube 422 has been previously provided with a frangible connector member 230 a. After introduction of the agent, an additional frangible connector member 230 d is preferably bonded or otherwise attached to inlet tube 420.
For additional protection from light, a second light impermeable overwrap may be provided over container 202, as shown in
Sleeve 426 may be pre-sealed on at least two sides. The container 202 with integrally sealed overwrap is inserted through an open end of sleeve 426. The frangibles may then be connected to the outlet and, after introduction of the treating agent, the inlet. The remaining open ends of sleeve 426 may be at least partially sealed to retain container 202 within sleeve 426.
The material used for sleeve 426 may be the same material as the one described above in connection with sheets 412 and 414. Also, it should be understood that use of the double overwrap arrangement described above, although preferred, is not required. In other words, container 202 may include integrally sealed sheets 412 and 414, or be simply inserted in a sleeve, such as sleeve 426.
In a preferred embodiment, containers 210 and 214 may be contained within or held together by a holder or organizer. In one embodiment, holder may be any device such as a clamp that holds together containers 210 and 214. The holder may be integral with the disposable processing set or may be provided separately.
More preferably, holder 260, shown in
Alternative embodiments of holder 260 are shown in
In one embodiment, container 210 is placed in the front portion of holder 260, such that a label to be applied to the container 210 and other indicia on the container itself are exposed to the outside environment through the open portion of holder 260 as shown in
As shown in
Organizer 500 provides a support for the containers of disposable processing set 200 by folding sheet 502 along line 512, as shown in
Once organizer 500 has been configured into the U-shape, the containers 210 and 214 are wrapped around organizer 500, as shown in
Illumination container 206 may also be wrapped over the packaged containers for purposes of initial packaging and shipment, as shown in
As described above and shown in
As shown in
Another alternative embodiment of an organizer is shown in
After the components have been mounted on organizer 700, sheet 702 is folded. Sheet 702 may include spaced perforations 713 to allow sheet 702 to bend more easily and give the bent sheet the desired, U-shaped profile described above, thereby avoiding creasing of the containers. Once folded, tabs 714 are inserted into slots 716. Tab 719 is provided on the outer side of sheet 702 to receive the slit in the illumination container (e.g., 244), which for initial packaging and shipment is wrapped over folded organizer 702.
When the set is ready to be used in the photoactivation treatment, container 244 is removed from organizer 702 and biological fluid is introduced into container 244 (for example, through container 202), as described. The container with biological fluid therein is then placed inside compartment 188 of drawer tray 90. The package with the components of the processing set inside is then placed inside compartment 90 of light drawer 50. Organizer 700 includes an additional large tab 724. Tab 724 is scored or perforated along lines 726 to allow tab 724 to be folded. When the package is inside compartment 90, the tab 724 is folded back and holes 728 and 730 are placed over pegs 193 in light drawer 50, as shown in
Preferably, organizer 700 and more specifically sheet 702 is made of a sturdy, yet flexible material. A preferred material for organizer 700 is polyethylene, but any material that can be die cut and handled in the manner previously described, and is sterilizable by forms of sterilization used to sterilize the disposable processing set (e.g, e-beam or gamma radiation) may also be used. It is also preferred that organizer 700 be substantially opaque (i.e., not transparent) so as to attenuate the light from the bag indicating sensors in the light box, thus confirming the presence of the containers.
c. Methods of Processing and Treating Fluid
The method of processing fluid using disposable processing set 200 (or 240) and treating a biological fluid with light in, for example, light box 10 will now be described. Although the following description will be provided in the context of processing the biological fluid for subsequent inactivation of pathogens in the biological fluid, it should be understood that many of the steps described below may also be carried out in other fluid processing and treating methods that do not involve pathogen inactivation. The following description will be provided using the disposable processing set of
In accordance with the method of processing a biological fluid such as blood using the processing set 200, a container of collected blood or biological fluid is provided. Although the method of collection is beyond the scope of the present application, representative methods of collecting blood products include the automated and manual centrifugal processing, separation and collection of blood products, membrane separation of blood products and the like. One example of a centrifugal blood processing system is the AMICUS� Separator sold by Baxter Healthcare Corporation.
Regardless of the collection method, containers of the collected blood product will typically bear a label that includes information identifying the donor, the blood product and lot numbers. Most typically, such information is presented in the form of one or more bar codes on the label which can be scanned and read by bar code reader, such as bar code reader 41 of light box 10. Such labels may be removable and transferable to container 214 of the disposable processing set 200.
Typically, the collection container will include a tubing segment extending therefrom. Accordingly, tubing from the collection container 201 and tubing segment 203 from the disposable processing set 200 are brought together and joined in a sterile manner, as shown generally in
Once tubing segments have been joined, frangible member 230 a is broken to provide an open flow path from the collection container 201 to the container 206 (
Before or after placement of the disposable processing set in tray 90, operator may scan the label and other container indicia with bar code reader 41. Bar codes 222 on the main container label 216 or the container itself provide the instrument with information regarding the biological fluid to be treated. Based on the data, the light treating instrument or operator prescribes the light dosage and then calculates the duration of the treatment.
Container 206 of disposable processing set 200 is typically placed in first compartment of tray 90. Slit 207 in container 206 is placed over retaining tab 186 in first compartment 188 and organizer 500 (or 700 ) with containers mounted thereon is placed within the second compartment 190 of drawer tray 90. Slits and/or apertures in container 216 are likewise placed over retaining tabs or pegs 193 in second compartment 190. Tubing connecting container 206 with container 210 (and/or 214) may be pressed into the slot in wall 192. It is preferable that the tubing be positioned parallel to the direction of the side-to-side oscillation provided by the agitator assembly described above. This further ensures that any fluid within tubing segment 208 is also mixed. Indicator 234 b not only serves as a reference point for severance of the tubing but also serves as a reference point for container placement by ensuring that substantially the entire container and biological fluid therein is within the field of light. The indicator has a diameter greater than the width of the slot.
Once the containers are in their respective compartments of tray 90, fluid carrying drawer 50 is closed. As set forth above, plunger switch 36 a (
Light box 10 includes a programmable computer software-based control system to control the operation of light box 10. The control system is generally and diagrammatically depicted in
For example as shown in
If the treatment function 306 is selected, the control system, through the programmed software will automatically determine if treatment is appropriate and more particularly, if the light box 10 is prepared for treatment as shown in
As shown in
After containers have been placed into tray 90, to commence treatment the system activates the light source(s) 100, shaker motor 92 and fans as shown in step 328 of
In one embodiment, container may be marked by markers 76 at the beginning of treatment and after treatment is completed. The marks made by marker 76 obliterate or otherwise masks the bar code, making it unreadable. Thus, a container with two masked bar codes 224 indicates that treatment has been successfully completed. On the other hand, if only one of the bar codes 224 has been masked, this serves as an indication that treatment was not successfully completed and the container may have to be discarded. Masking of bar codes 224 by markers 76 also ensures that a treated container will not be treated again.
During treatment, the system performs an energy calculation 332 which is computed by multiplying the light intensity sensor readings by preselected calibration factors, averaging the readings across the sensors in the same chamber and plane and adding the reading received for planes in the same chamber. The control system further verifies the treatment status 334. If treatment is completed, the system will automatically turn off lamps 100 as shown in 336.
The system may automatically update information on the lamp life as shown in 337 and update container records 338. Control system may continue to power shaker motor 92 until terminated. The results may be transmitted to a central computer 502 (
Treatment time and energy dosage will vary depending on the biological fluid to be treated. For example, the treatment time may be at least one minute but may also be less than one minute. Where light box 10 is used for the pathogen inactivation of biological fluid, the treatment may typically be anywhere between 1-30 minutes. For example, for the pathogen inactivation of blood platelets, treatment is typically between 1-10 minutes, but more typically approximately 3-4 minutes. For the pathogen inactivation of blood plasma, treatment may also preferably be approximately 3-4 minutes.
Energy per unit area, or energy flux, is the product of power per unit area or, in the case of radiant flux, at the target, and the time of exposure. Accordingly, the amount of energy per unit area delivered to the target (for example, in one embodiment, the biological fluid) will vary with the duration of exposure and the irradiance—the radiant power per unit area incident on the target. In one embodiment the total radiant energy flux delivered may be between approximately 1-100 J/cm2 measured across a wavelength range of between approximately 300-700 nm. However, any useful wavelength that activates photochemical agents may be used. In general, light box 10 can be retrofitted for various illumination frequencies to illuminate treatment targets in treatment chamber 40, including those light frequencies outside of the range of 300-700 nm. In another embodiment, where the light source provides light generally in the ultraviolet range, the total radiant energy flux delivered to the biological fluid may preferably be between 1-20 Joules/cm2 measured across a wavelength range of between approximately 320-400 nm. In one specific embodiment, the total radiant energy flux delivered to blood platelets or blood plasma may be between approximately 1-5 J/cm2 and more typically approximately 3-4 J/cm2 measured across a wavelength range of between approximately 320-400 nm. Preferably, the energy should not be outside the predetermined range in that excess heat generated within fluid treatment chamber 40 is to be avoided. For light treatment of blood platelets and blood plasma, for example, temperature within chamber 40 should typically not exceed 37� C. If an external temperature sensor of the type described above is used, the ambient temperature should be between 18�-30� C.
During treatment, tray 90 is preferably agitated at a preset frequency. Of course, the frequency should not be so great so as to harm the biological fluid or components thereof. Typically, the tray 90 may be agitated between approximately 400-100 cycles/min and for blood platelets, more preferably, between approximately 40-80 cycles/per minute. A cycle is defined as one complete back and forth oscillation of drawer 80. Additionally, it may be desirable for agitation to continue for up to 30 minutes after blood platelets have been treated with the desired target light dose, i.e., after illumination in light box 10 is terminated.
Once treatment has been successfully completed, fluid from container 206 may be transferred to container 210 by breaking frangible number 230 b and opening the flow path between the containers 206 and 210 (
Alternatively, in the disposable processing set 240 shown in
The residence time, if any, of the biological fluid in container 210 (or 246) will be anywhere between approximately 30 seconds and 7 days. In addition, during contact of the biological fluid with the adsorbent material of container 210, it may be desirable to shake or otherwise agitate container 210 to ensure maximum contact with the adsorbent material.
Regardless of which disposable set is used, after the required residence time, if any, the biological fluid may be transferred to container 214 (or 248 in
In addition to the treatment function generally described above, the control system may prompt the operator to perform other functions such as the maintenance function 336 which may include printing a maintenance log 338, resetting lamp hours 340 resetting bag marker count 342. The operator may also select a system settings function 343 which allows the operator to set dates, times, languages 344,346,348. Finally, the control system may allow the operator to perform certain container management functions such as transmitting or printing container records or overwriting container records 350, 352, 354 as generally depicted in
Alternatively, the diagnostics function shown in general in
It will be appreciated that various modifications of the embodiments and methods described herein are possible in accordance with the scope of the present invention which are set forth in the appended claims.
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This publication has been developed to assist designers in the proper understanding and determination of structural loads in accordance with the 2012 edition of the International Building Code® (IBC®) and ASCE/SEI 7-10, including dead load, occupancy live load, roof live load and environmental loads such as rain, snow, ice, flood, wind and seismic loads. This updated edition includes a new chapter on load path, a new section on atmospheric ice loads and completely updated discussion of the new wind design procedures in ASCE/SEI 7-10. The new edition also includes problems at the end of each chapter along with an online solutions manual.
PURCHASE THE PDF DOWNLOAD VERSION AND GET IMMEDIATE ACCESS!!! This convenient option is a searchable PDF download that requires Adobe® Reader® 10.0 or later. You must have this version to be able to load and access the product. The download is protected from duplication by Protectedpdf™. You are required to login to our secure server and register your copy. You will be able to install this software no more than two times as provided in the license agreement. Neither concurrent use on two or more computers nor use in a local area network or other network is permitted. These documents are for computer use only and are not compatible with iPad, Android, or Blackberry devices.
The load requirements in the 2012 IBC and ASCE/SEI 7-10 are presented in a straightforward manner with emphasis placed on the proper application of the provisions in everyday practice.
The structural load provisions are organized in comprehensive flowcharts that provide a road map to guide the reader through the requirements. Included in the flowcharts are the applicable sections numbers and equation numbers from the IBC and ASCE/SEI 7 that pertain to specific requirements.
Although the book is geared primarily for practicing civil and structural engineers, engineers studying for licensing exams, structural plan check engineers and civil engineering students will find the book a valuable resource because of its clean, straightforward approach. This publication is also an excellent resource for architects, code officials, plan reviewers and others who need to understand how to determine structural loads based on the IBC and the ASCE/SEI 7 standard.
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After All Photography is company of professional photographers, founded by photographer George Zorich. George is professional photographer with 12 years experience in professional photography. He has earned degree in commercial and art photography. George himself has over 100 successfully internationally photographed weddings. After All Photography provide unique service in all photography genres, especially in wedding. For more info please visit our website.
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Latest News
- WORLD EXCLUSIVE: Ben Affleck and Jennifer Garner's Emotional Post-Split Vacation
- They're Ready for Love: Plain White T's Tim Lopez Weds Jenna Reeves – See the Photos
- See Prince George's Nanny in the Mary Poppins-Style Uniform She Wore to Princess Charlotte's Christening
- A 50-Year-Old Stroller and 4-Year-Old Cake: Princess Kate and Prince William Look to History for Princess Charlotte's Christening
- Prince George Wears Lookalike Outfit to His Dad, Prince William, at the Same Age!
- First Photos of the Royal Family of 4! Princess Kate, Prince William, Prince George and Princess Charlotte Enter Church for Christening
- Rain, Rain Go Away – It's Princess Charlotte's Christening Day!
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Storm damage impact revealed at fishermen's meeting
Posted: March 07, 2014|
FISHERIES minister and Camborne Redruth MP George Eustice visited Newlyn on Friday to meet the county's storm-ravaged fishermen.
Before meeting a group in the Seamen's Mission, including representatives from Porthleven, Cadgwith, Newquay and Padstow as well as from Newlyn, Mr Eustice and Derek Thomas, the Conservative parliamentary candidate for the West Cornwall constituency, were taken on to the quay by Robert Broderick, a shell fisherman who fishes out of Newlyn.
He said the storms had resulted in not only a lack of opportunities to go fishing but also a loss of fishing gear.
"I've only managed to get out to sea on six days since the start of December – normally I would expect to be out 15 days a month at his time of year so we've basically had no wages for three months," he said.
"Not only that but we've also seen about 500 of our 1,200 crabpots destroyed or damaged because of the storms."
Mr Broderick pressed his case to Mr Eustice for help from the Government but said the minister had not committed himself to anything.
"He took everything on board and listened but made no promises," he added.
"We are seeking a hardship payment, a gear replacement payment or a low interest loan."
Mr Eustice said he appreciated that it had been a very difficult time for Cornish fishermen. "I wanted to come here to Newlyn to see the problems for myself," he said.
"In many cases, fishermen have only been able to get to sea for seven or eight days over the past three months – we have had an exceptional winter with storm after storm.
"Crab and lobster fishermen have lost almost half their pots due to storm damage and so we are looking at a crisis fund and the details of how the Government could help.
"In addition we have already asked the MMO to show the maximum flexibility over quotas, particularly for the Under 10 metre fleet and the Department for Transport is looking at funds to repair the damage done to harbours while some of the larger vessels will be able to defer their lighthouse dues. I will be taking what I have learnt here today back with me to Westminster. We are looking at the damage done to our fishing industry and how we can help. I hope to have something positive to announce in the near future."
Mr Thomas added: "I asked George to meet these fishermen when I became aware of the crisis that shell fishermen in Newlyn are facing. It is important that fishermen can impress upon government ministers in person the importance of our fishing industry and how recent storms have created unprecedented difficulties for it."


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Deakin home > Deakin Research > IFM
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News and Events
Double ARC success for metals research
Tue, 07 Jul 2015 17:31:00 +1000
Deakin has been awarded two Australian Research Council Linkage Scheme awards. Read more
Graphene coatings make steel corrosion-resistant
Fri, 05 Jun 2015 16:23:00 +1000
IFM researchers have grown graphene flakes directly onto stainless steel, improving the metal's resistance to corrosion. Read more
Short fibre technology gets boost with manufacturing partnership
Wed, 03 Jun 2015 14:48:00 +1000
The new Innovative Manufacturing CRC is set to benefit Australian industry. Read more
Science Academy honour for Maria Forsyth
Mon, 25 May 2015 10:06:00 +1000
Australian Laureate Fellow Prof Maria Forsyth has been elected to the Australian Academy of Science. Read more
Modelling gives insights for better molecule design
Thu, 21 May 2015 14:00:00 +1000
Researchers are using a combination of molecular simulation and experimental techniques as a way towards rational design of metallic nanoparticles. Read more
Green light for fibres Industrial Transformation Research Hub
Wed, 20 May 2015 13:08:00 +1000
A $4.7 million future fibres Research Hub is to be established at Deakin. Read more
Deakin contributes to China's wind energy sector
Wed, 29 Apr 2015 16:43:00 +1000
Deakin has signed an agreement with the Dongfang Turbine Company, one of China's largest state-owned enterprises. Read more
'Father' of plasma research has visited Deakin
Tue, 28 Apr 2015 11:16:00 +1000
Prof Riccardo D'Agostino has shared his knowledge, as Thinker-in-Residence, with Deakin researchers and local industry. Read more
New research to realise the sensor 'pipe dream'
Wed, 15 Apr 2015 11:40:00 +1000
A novel sensor is set to help extend the operational life of energy pipelines by decades. Read more
Big breakthrough for tiny diagnostics
Wed, 08 Apr 2015 12:08:00 +1000
Biophysicist Wren Greene has uncovered the unique properties of the protein lubricin. Read more
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- Price: $64.00
- Exclusive Price: $2850.00
Chendler Online Flash Template 28676
Flash 8 Site Template that was composed by our webmaster artist Irene.
Description, Sources, Software & Requirements
A simple bakery website template with four images in the center of the page linking to different sections. Above the four images is the site logo. The background is a really dark brown color with a circle, dots, and leaf design seen really faintly. The four sections are: Services, About Us, Location, and Gallery. The four images are of bread, a baker holding a rolling pin, an outside image of a bakery shop, and 6 muffins. Chendler Online Flash Template 28676 has a width of 2000 pixels and is available in the following sources: .SWF, .HTML, .PSD, and .FLA. Software required includes Winzip 9+ (Windows) or Stuffit Expander 10+ (Mac) for uncompressing .zip files, Adobe Dreamweaver 8+ (or Microsoft Expression Web), Adobe Photoshop CS+, and Adobe Flash 8+. It has had a total of total of 6 downloads since it first appeared.


text:
Add Samsung to the multitude of vendors announcing new Ultrabook models at CES this year. The company is entering the category with the Series 5 Ultra family, consisting of both a 13.3- and 14-inch model. The design of these thin, stylish portables is clearly influenced by the Series 9 laptop, which itself has undergone an update.
The 13.3-inch Series 5 Ultra weighs 3.24 pounds. It comes with a 1.6GHz Core i5 2467M, 4GB of RAM, and either a 500GB HDD or 128GB SSD. Its matte screen has a 1366x768 resolution. The laptop offers one USB 3.0 port, two USB 2.0 ports, full-size HDMI, an Ethernet port, and a 4-in-1 media reader. It's $900 with the HDD; $1,100 with the SSD.
The 14-inch Series 5 Ultra sports a 1.6GHz Core i5 2467M, 4GB of RAM, and a 500GB HDD. Notably, it's the first so-called Ultrabook to feature an optical drive. Nevertheless, it rings in at less than four pounds—3.94 pounds, to be exact. Like the 13.3-inch model, its matte screen is 1366x768. Its port selection, however, differs slightly, consisting of full-size HDMI, VGA, two USB 3.0 ports, one USB 2.0 port, and Ethernet port, and a 4-in-1 media reader. It's priced at $950.
Step up to a higher class of thin-and-light, and you get Samsung's Series 9 family—in both 13.3-inch and 15-inch sizes. The new Series 9 models are every bit as stylish and sophisticated as the originals that turned heads last year, but feature some subtle changes. For one thing, they're a bit thinner and lighter. Weighing 2.5 pounds and 3.5 pounds, respectively, the new Series 9 are just .5 inches at their thickest. They full-aluminum unibody construction, 1600x900 screens, backlit keyboards. The 13.3 inch model features a 1.6GHz Core i5 2467M with 4GB of DDR3 and a 128GB SSD. The 15-inch model has the same proc and SSD, but 8GB of DDR3. The price for the 13.3-inch model is $1,400; the 15-inch model is $1,500.


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Burton Launch Insulated Jacket - Men'sView Larger Image
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Fire your carcass into the stratosphere in the Burton Men's Launch Jacket. The Launch will fight off the weather all day and make sure you're looking good whether you're sticking your landings or starfishing into the woods.
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Miami Vice: Season 3, Episode 15
The Savage (6 Feb. 1987)
When some prostitutes are being killed, Castillo recognizes the M.O. as similar to some killings he saw when he was in Vietnam and working with a Vietnamese investigator. And the investigator shows up in Miami.
Director:John Nicolella
Writers:Anthony Yerkovich (creator), Marvin Kupfer
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Originally written on Fox Sports | Last updated 4/6/13
Former Baltimore Ravens reserve linebacker Brendon Ayanbadejo is taking his support for gay marriage to South Florida, where his career started. The 36-year-old Ayanbadejo (eye-uhn-bah-DAY'-joe) was making his announcement alongside the civil rights organization Equality Florida on Tuesday in Fort Lauderdale. He says focusing on this ''bigger calling'' is the ''right thing to do.'' An open proponent of gay marriage, Ayanbadejo spoke in favor of it in November, before Maryland passed a law allowing it, and also prior to the Super Bowl. He also recently spoke at a rally on the steps of the Supreme Court. Earlier this month, he told The Baltimore Sun that up to four NFL players may soon come out as gay. Ayanbadejo started his career with Miami in 2003.
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text: No recent wiki edits to this page. Background StoryHer parents were killed by GAIN as a child. To avenge the death of her family, she joined the army and eventually became a member of the Green Berets. She was then assigned to spy on the secret organization, GAIN. She later found out, that the man responsible for the death of her parents, Elg, was an executive of GAIN. The loss of her parents has turned her into one tough girl!Weapon: Automatic handgunPower: MediumShooting Speed: Fast6 shots availableTraps:Mine - 5Gas - 1Force Panel - 3


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News & Alerts
- June 18, 2015 • PRESS RELEASE
Fraud Charges Brought Against 40 Individuals by the Alaska Department of Law and U.S. Attorney's Office
The Alaska Attorney General's Office and the U.S. Attorney's Office announced today that 40 individuals were charged with crimes for medical assistance fraud, conspiracy to commit health care fraud, public assistance fraud and PFD fraud.
- June 15, 2015 • PRESS RELEASE
Special Investigators National Guard Report Released
Attorney General Craig Richards today released the public report from the special investigator, retired Superior Court Judge Patricia Collins, regarding the Alaska National Guard (AKNG).
- June 1, 2015 • PRESS RELEASE
Impacts Expected to Department of Law if Partial Shutdown Occurs
If a partial shutdown occurs, the Department of Law will see a reduction in staff in both the Civil and Criminal Divisions, resulting in a reduction in services on all criminal and civil matters.
- May 2015 • CONSUMER ALERT
Alaska Joins Settlement with Classmates, Inc. and FTD for Misleading Advertising and Billing Practices
The Alaska Office of the Attorney General joined with 21 other states in a settlement with Classmates, Inc. and Florists Transworld Delivery ("FTD").
- May 19, 2015 • PRESS RELEASE
Alaska Joins Federal, State Crackdown on Four Cancer Charities
The Alaska Department of Law joined 49 states, the District of Columbia, and the U.S. Federal Trade Commission in a joint complaint charging four cancer charities and their operators with scamming consumers.
- May 2015 • CONSUMER ALERT
Alaska Joins Settlement with Equifax, Experian and TransUnion
Under the settlement, the credit reporting agencies have agreed to make a number of changes to their business practices to benefit consumers.


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Prices and availability are subject to change from the time and date that you print this page.
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The Story
Modern technology and a sleek, retro-inspired design combine in this stainless-steel hand vacuum with 500 watts of power and a state-of-the-art, fan-enclosed motor. Lightweight vacuum includes upholstery tool, power unit, crevice tool, dust brush, upholstery nozzle, flexible hose and shoulder strap. Metropolitan has been making vacuums in the U.S. since 1939.
Details and Dimensions
Metropolitan VM6 Stainless-Steel Hand Held Vacuum. 4"Wx12.5"Dx5.25"H
- Stainless-steel construction
- 500 watt fan-enclosed motor (110 volts at 4.5 amps)
- Weighs 2.7 lbs.
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- Clean with a dry cloth
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Overall DimensionsWidth: 4" Depth: 12.5" Height: 5.25"
Warranty Available View the manufacturer's warranty (PDF)
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We will accept returns and exchanges of non-furniture items if:
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If you discover an item has a manufacturer's defect or was damaged during transit, we will accept the item for return or exchange with proof of purchase. Without proof of purchase, the item can be exchanged only for the same item. A valid photo ID is required.
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Items must be returned to the store brand where the purchase originated or by mail (if the item was ordered online or by phone and received by mail). Purchases made outside the U.S. may only be returned to the purchase location.


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We offer discount to nonprofits, government agencies, and federal contractors
In just the last two weeks, congressional calls to #EndFamilyDetention have turned the tide of momentum significantly.
AILA Doc No. 06052412 | Dated May 24, 2006 | File Size: 32 KDownload the Document
This is the inaugural issue of the Pro Bono Newsletter. Topics include AILA Wants to Recognize Your Pro Bono Work; Promote Your Organization or Program; New York Chapter Hosts Event; Know Your Rights Materials; Pro Bono Feature—Tour of the Border; Volunteer Opportunities & BIA Appeals Project.
[[To print the PDF on this page please use the print function in the PDF reader.]]
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Movie details
Billy Madison (1995)
An adult goof-off goes back to elementary school in order to run his father's company.
Adam Sandler, Darren Mcgavin, Bridgette Wilson, Bradley Whitford, Josh Mostel, Norm Macdonald, Mark Beltzman, Larry Hankin, Theresa Merritt
Tamra Davis (Director), Tim Herlihy (Writer), Adam Sandler (Writer), Fitch Cady (Executive Producer), Robert Simonds (Producer)
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Do you need an excellent environmental lawyer to help you? To ask if our award-winning environmental law firm can take your case, please fill out the Potential Client Form and email it to our Office Manager, Elaine Cohen at admin @ envirolaw.com or fax it to the number listed below. That will allow us to check if:
- we think we can help you;
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Product Information
Do Lord Remember Me composed by African-American Spiritual - Digital Sheet Music (Easy Piano)
At a Glance
Do Lord Remember Me digital sheet music. Contains printable sheet music plus an interactive, downloadable digital sheet music file.
* This arrangement contains complete lyrics
* This product is available worldwide
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The Arrangement Details Tab gives you detailed information about this particular arrangement of Do Lord Remember Me - not necessarily the song.
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The Magazine
Obama's Injustice Department
The irresponsible Office of Professional Responsibility.
May 25, 2009, Vol. 14, No. 34 • By MICHAEL STOKES PAULSEN
This view is informed by my experience both as a law professor and, nearly two decades ago, as an attorney in the Office of Legal Counsel (OLC) of the Department of Justice--the same office that provided the advice in question during President George W. Bush's administration. The types of constitutional and statutory arguments made in the disputed memos are consistent with longstanding OLC positions with respect to presidential power under Article II of the Constitution. They involve subtle niceties of constitutional law and history. OPR attorneys are, as a rule, not as conversant in such matters. To put the point in terms of legal ethics: Were the Office of Professional Responsibility to purport to pass judgment on the competence of the constitutional and statutory analysis of the OLC memos, it would be straying far beyond its areas of purported competence.
When I teach legal ethics, I tell my students that one aspect of competence is to know what you know and to know what you don't know, and to stay away from the latter. It is fair to wonder whether staff attorneys in OPR--whose actions with respect even to the law of legal -ethics appear so dubious--possess the requisite professional skill, expertise, and knowledge to competently evaluate (let alone second-guess) OLC lawyers' analysis of constitutional law, treaties, international law, and complicated criminal statutes. We will see: If OPR's leaked report becomes public and indeed takes the Bush team to task on grounds of professional legal competence, it will be fair to ask whether OPR attorneys really understand the substantive law they are talking about--or whether the charge of incompetence falls more heavily on their own heads.
Unethical leaks and confidentiality violations; outsourcing federal responsibilities; basic misunderstandings of legal ethics principles; incompetent analysis of constitutional, international, treaty, and statutory law. What more could be wrong with an ethics office's actions? It is hard to know for sure--without seeing OPR's report--the full extent to which it contains all of these problems. But leaked accounts of the OPR's draft report so far call that office's ethics and professionalism into question more than they do those of anyone else.
Michael Stokes Paulsen is university chair and professor of law at the University of St. Thomas, in Minneapolis. He was an attorney-adviser in the Office of Legal Counsel from 1989-91.


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Coming to America...
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Wage slave...
Joined: Jul 2002
Location: Scarning, Norfolk, today...
Oddometer: 7,090
15th April
The weather was fine when I got up, but forecast to clag in later in the day. After a quick 'surf' at the Hard Drive Café, I pack the bike and head up the 26 towards the Idaho state line…
…the road starts entering some
…this pass tops out at 8200 ft.
I ride over the border into Idaho, heading towards Idaho Falls. I ride through the city, remembering why I try to avoid large conurbations :( Eventually I'm out the other side heading West on the 20. There is a strong wind from the South West, with
strong gusts. It makes riding the bike very uncomfortable, especially when oncoming traffic causes a sudden 'gap'. The wind is blowing the top soil off the fields to the right of the road – the plume of dust is visible for over 30 miles…
Eventually I reach Pickle's Place in Arco – a restaurant and very welcome refuge from the wind. I ask the waitress if it's always this windy… 'No, honey – sometimes it gets real bad…' :P
After lunch I continue North West, sheltered from the wind to a large extent by the range of hills which now line the road…
I turn right up the 93 towards the town of Salmon, where I intend to stop for the day. The road gets more picturesque the further I head North…
…as it follows the course of the Salmon River (the longest undammed river in the continental USA)…
…to the small town of Salmon - population 3000, elevation 4000ft - which apparently survives on fishing and tourism…
In the evening I go to the local cinema, The River, to see Hidalgo, which proves to be a disappointment – I was hoping for something a little less "let's show the Arabs we Americans can do it best, especially when the deceitful British are concerned" :P – beautifully photographed – but subtle, it wasn't ...
The cinema itself was like a trip back in time – it was clearly a traditional 'one screen' cinema when built – the current owners must have spent literally
of dollars converting it to the poorly focussed, badly ventilated hole with terrible acoustics that it is today.
It also seems to be culturally acceptable to continue conversations throughout the film, if the middle aged couple behind me were anything to go by – still, at least I now know where to get the best value oil change done on a Durango… ;)
All text & original photos © Mike Oughton 2004 - 2015
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IBEROSTAR Costa Dorada
Our guests reviewsIBEROSTAR Costa Dorada
Ryan Mc Meeking says: about 1 year
What does "resume your experience" mean? Maybe you need to have an English speaking person revise this, as it makes utterly no sense.
"Overall excellent. Only drawback was that the front desk was unable to make decisions in a timely manner. Another couple was with us for their honeymoon and were given a room with two double beds instead of a king-sized bed. It took until the following afternoon to resolve the issue. I was a return customer to Costa Dorada and, despite having e-mailed ahead of time, was not welcomed back in the usual custom as my parents (who have stayed at this resort 3 times and once with my uncle and aunt). Everything else was perfect. Food great. All staff great. Entertainment great."Rating: 9,0
Cecilia says: over 1 year
I will definetly be going back to this resort.
"Had a wonderful stay at Iberostar Costa Dorado,Puerto Plata, Dominican. I will def. be going back to this resort and telling my friends about it. Only thing I would add is a Canadian tv channel so we can follow the news from back home. Staff is extremely friendly!"Rating: 9,0
Cat Ber says: over 1 year
On a positive note....the popcorn chicken was delicious. One of our group ordered some for us all & it was delivered to our table personally by the chef & Robert!!! Very tasty & hot & when asked they delivered bowls of BBQ sauce! There was a nice perso
"Please try to improve on your A la Carts! We did the Brazilian only & were happy with that but through word of mouth did not go to the other two. We were told they weren't worth going to. So....we attended the buffet all other nights & were getting tired of the food at the end of our week........"Rating: 8,0
Jim Martell says: over 1 year
Good resort and enjoyable time, I was allowed to practice my spanish, muy bien.
"Delightful time at resort. Great animation team especially Ritchie, Betty Boop, Chocolate, and Popeye. You have the best pool bar man Isidro excellent... Cleaning staff were friendly and helpful. Fridge a bit warm. We stayed for 2 weeks so we had lots of experiences. I would have preferred more time exploring city of Puerta Plata but had to fear locals for theft and robbery. Next time we will go into town via the bus and experience the downtown. I believe the people are your most valuable resource. The mercado ala carte restaurant was well staffed and they earned their tips. Champagne was a nice touch. As a traveller in a foreign country i would have like to have the cost of a room safe and wifi included or listed in our initial booking. That was the only items I felt could be improved. The room safe should be explained at check in. Otherwise everyone was friendly and helpful. I would have like the local tour to be a little less pushy for items that were not for us (necklaces beads etc.) "Rating: 7,0


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Cooking and Baking
Need a Sauce for Lobster Ravioli
I have to try the lobster ravioli I have seen recently in the Italian import store, but I'm not sure of a sauce to serve with it. I have to keep it kind of simple because I am working with limited kitchen capacity at this time. Don't want anything tomato based. Has anyone had a "killer" lobster ravioli sauce they can pass along?
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One of the cornerstones of motion graphics is creating and animating type. In this course, Trish Meyer shows how to typeset titles professionally and create custom animations, as well as apply and modify the hundreds of text animation presets that After Effects ships with. Additionally, Chris Meyer shows how to add audio to projects, including spotting "hit points" to align keyframes and video action.
The After Effects Apprentice videos on lynda.com were created by Trish and Chris Meyer and are designed to be used on their own and as a companion to their book After Effects Apprentice. We are honored to host these tutorials in the lynda.com Online Training Library®.
If you have the exercise files, go ahead and open comp 07-3D Rotation*starter. If you don't have the exercise files, just create a cascading animation with Opacity set to 0%. With the cascading animation, more than one character at a time is typing on, so when you add rotation, you'll have a more interesting effect than if you were using a simple typing-on animation. So the first thing I'm going to do is click on either Add or Animate and select Property > Enable Per-character 3D.
And, by the way, this will enable Per-character 3D for all of your animators, if you have more than one. Next, I'll select Add > Property > Rotation, and instead of just one parameter called Rotation, I'll see X, Y, and Z Rotation. If you don't see all three parameters, make sure that you have indeed Enabled Per-character 3D, that it's checked, and that you haven't simply turned on the 3D switch, say, for your layer. Now, before I change any of the values for Rotation, I will change my View pop-up to Custom View 1.
Now you can see the layer at an angle, and you can also see the 3D axis arrows more easily--particularly the Z axis arrow, which you can't see when you're looking straight on. When you're playing with Rotation, think of each axis arrow as a pole around which the characters will animate. So I'll go ahead and change my X Rotation value, and you can see these characters that are selected, twirling around. And I'll set it to a pretty high amount. So as the animation progresses, the characters are animating around the X axis, and I'll RAM preview, so you can see the full effect.
When you first start exploring Rotation, I advise you to undo and try each one separately. That way you can get a good handle on how the rotation is actually working. I think I'll tone down the Y axis a little. And that's actually a really nice effect. It's very simple and easy to do. I'll undo again, and I'll go back to 0. Now the Z Rotation will look exactly like what we're used to when we're animating in 2D.
And of course, you can adjust the X, Y, and Z Rotation all at the same time. I could try a little X, add some Y Rotation, and even a little Z, and RAM preview. Now, all of the other techniques you've learned, such as enabling motion blur, typing on in a random order, adjusting the anchor point, and even easing in, can all be applied to a Per-character 3D animation. So let's try a couple of those.
I can Add > Property > Anchor Point, and when I do, you'll see it has an X, Y, and Z value. The Z value allows you to adjust the anchor point in front of and behind the postcard in space. Of course as the characters fly down into position, the Offset value for Anchor Point fades down to 0, just as the Rotation value also fades away. Now, we saw earlier how we can adjust the anchor point in another way. If you remember, under More Options, the Grouping Alignment parameter allows you to adjust the anchor point.
Although I have Per-character 3D enabled, the Grouping Alignment parameter only works on the X axis and Y axis; however, it's a very nice way of setting the anchor point to the center of the characters. Now as they come into land, they don't appear to be rotating around the baseline. And if I return to the Anchor Point and zero out the values, now the characters swivel around the vertical center, instead of the baseline. If you remember earlier, we discussed the Ease Low parameter. That's like an ease-in value for characters.
So I'll set my Anchor Point Z value back a little bit. With Ease Low set to 100%, they spend a little bit more time landing softly. Now remember, you could also enable motion blur. A motion blur can look really great when characters are moving quickly. So have a little fun exploring the 3D options, but remember that most of the properties look no different when Per-character 3D is enabled-- and that includes Opacity, Fill Color, Tracking, Character Offset, and Value, and Blur.
And once you come up with an animation you really like, you'll be able to save that as an animation preset, and we'll be covering that a little later on. In the next chapter, I'll show you how to add the Wiggly selector, and that's a lot of fun.
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WALLA WALLA - The women ran wild for the Whitman College cross country team at the Whitman Invitational on Saturday, with twins Emilie and Katri Gilbert taking the top spots in the 6,000 meter race.
The men were not as successful, with runners from Lewis-Clark State College taking the top seven spots in the 8,000 meter.
Lewis-Clark was the only other school to attend the meet, due to the long weekend, according to a Whitman press-release.
Emilie took home a time of 23 minutes, 24 seconds and Katri was not far behind, finishing in 23:47. Freshman runner Erin Campell took fourth overall, third for Whitman, finishing 24:04.
"It was amazing watching Emilie run this race," Whitman coach Scott Shields said in an email. "She had a deal with (Lewis-Clark) number one runner for the first 4k of the race and then started to pull away and never looked back."
Katri Gilbert ran a different style of race, despite finishing within 27 seconds of her sister.
"Katri was able to catch (Lewis-Clark's) number one runner throughout the race and beat her by three seconds in the end," Shields said. "Katri really had to have a great race and she stepped up to the challenge today; more importantly, she did not have a very good year last year, so for her to come up this big at this point in the season was awesome."
Lewis-Clark took the third and fifth spots, with the Missionaries rounding out the rest of the top ten.
On the men's side, first year runner Oliver Wood was the first Missionary to finish, taking the eighth spot with a 27:50 time. Michael Jorgensen came in ninth, with a 28:01.
Despite his male runners failing to crack the top five finishers, Shields was proud of the way his top finishers ran.
"It was fun to watch Oliver and Michael stay focused and run a solid race," Shields said. "With the strong runners from LC they could have easily gotten carried away in the beginning of the race and gone out too fast, they kept their heads and performed very well."
Whitman's next event is on Sept. 17 at the Sundodger Invitational at Lincoln Park in Seattle. The meet is hosted by the University of Washington.
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Peanut Butter Chocolate Cuffins
|All-purpose flour
|2 Cup (32 tbs)
|Granulated sugar
|2 Cup (32 tbs) (Around 500 milliliter)
|Dry cocoa
|3⁄4 Cup (12 tbs) (Around 175 milliliter)
|Baking soda
|1 Teaspoon (Around 5 milliliter)
|1 Teaspoon (Around 5 milliliter)
|Baking powder
|1⁄2 Teaspoon (Around 2 milliliter)
|3⁄4 Cup (12 tbs) (Around 175 milliliter)
|3⁄4 Cup (12 tbs) (Around 175 milliliter)
|3⁄4 Cup (12 tbs) (Around 175 milliliter)
|5 Milliliter (Around 1 teaspoon)
|Softened cream cheese
|6 Ounce (Around 175 G)
|Creamy peanut butter
|2⁄3 Cup (10.67 tbs) (Around 150 milliliter)
|1⁄4 Cup (4 tbs) (Around 50 milliliter)
|1 Teaspoon (Around 5 milliliter)
|Icing sugar
|3 Cup (48 tbs) (Around 750 milliliter)
In a large mixer bowl, combine flour, sugar, cocoa, baking soda, salt and baking powder.
Make a well in the center.
Add shortening, buttermilk, water, eggs and vanilla.
Beat on low speed for 30 seconds, scraping sides of bowl.
Then beat on high speed for 3 minutes.
Spoon batter into prepared muffin tin, filling cups three-quarters full.
Bake in preheated oven for 20 minutes or until toothpick inserted in center comes out dry.
Remove from pan and cool completely.
Meanwhile, in a large bowl, beat together cream cheese and peanut butter.
Add milk and vanilla, beating well.
Gradually add icing sugar and beat until smooth.
(If necessary, add additional milk until a smooth consistency is reached.) Spread over cooled cuffins.
NOTE: To make this cuffin even more special, take a pastry bag with a large star tip and fill with icing.
Insert the tip into the center of each cuffin.
Pipe some icing into the cuffin and add a swirl on top.


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Press release from CNW Group
PEER 1 Network Enterprises, Inc. announces intention to commence Normal Course Issuer Bid
Wednesday, May 09, 2012
PEER 1 Network Enterprises, Inc. announces intention to commence Normal Course Issuer Bid16:35 EDT Wednesday, May 09, 2012VANCOUVER, May 9, 2012 /CNW/ - PEER 1 Network Enterprises, Inc. (TSX:PIX), operating as PEER 1 Hosting, a leading provider of online IT infrastructure, announced today that it has received approval from the Toronto Stock Exchange (the "TSX") of a Notice of Intention to commence a Normal Course Issuer Bid through the facilities of the exchange. The Normal Course Issuer Bid will permit PEER 1 to repurchase for cancellation up to 3,112,406 of its common shares, being 2.5% of PEER 1's issued and outstanding common shares (as at May 8, 2012). PEER 1 had 124,496,266 common shares issued and outstanding as at May 9, 2012. The average daily trading volume of PEER 1's common shares for the period between November 1, 2011 and April 30, 2012 was 33,864 common shares. In accordance with the rules of the TSX, the maximum number of common shares that can be purchased on a daily basis by PEER 1 is 8,466 common shares, subject to the block purchase exception.The board of directors of PEER 1 believes that market prices of the Company's common shares may not fully reflect the value of its business and future business prospects, that current market conditions may provide opportunities for PEER 1 to acquire common shares at attractive prices and that the purchases are an appropriate use of funds and will enhance shareholder value.PEER 1 previously commenced a Normal Course Issuer Bid on May 16, 2011 (the "2011 NCIB"), which will expire on May 15, 2012. At present, PEER 1 has not made any purchases under the 2011 NCIB. PEER 1's 2012 Normal Course Issuer Bid will commence on May 16, 2012 and it will run until the earlier of the date on which purchases under the bid have been completed, the date on which PEER 1 terminates the bid, and May 15, 2013.About PEER 1 HostingPEER 1 Hosting is one of the world's leading IT hosting providers. The company is built on two obsessions: Ping & People. Ping, represents its commitment to best-in-breed technology, founded on a high performance 10Gbps FastFiber Network™ connected by 18 state-of-the-art datacenters, 22 points-of-presence and 10 colocation facilities throughout North America and Europe. People, represents its commitment to delivering outstanding customer service to its more than 10,000 customers worldwide, backed by a 100 percent uptime guarantee and 24x7x365 FirstCall Support™. Info-Tech Research Group recently named PEER 1 Hosting as a "Champion" in its Canadian colocation and managed services Vendor Landscape report, recognizing the company's strength in product offerings and enterprise strategy in the global IT marketplace. PEER 1 Hosting's portfolio includes Managed Hosting, Dedicated Servers under the ServerBeach brand, Colocation and Cloud Services under the Zunicore brand. Founded in 1999, the company is headquartered in Vancouver, Canada, with European operations headquartered in Southampton, UK. PEER 1 Hosting shares are traded on the TSX under the symbol PIX. For more information visit: www.peer1.com or www.peer1hosting.co.uk.Forward Looking StatementsStatements in this release relating to matters that are not historical fact are forward-looking statements based on current expectations, forecasts and assumptions that involve risks and uncertainties that could cause actual outcomes and results to differ materially. Factors that could cause or contribute to such differences include, but are not limited to, general economic conditions, changes in technology, reliance on third party manufacturing, managing rapid growth, global sales risks, limited intellectual property protection and other risks and uncertainties described in PEER 1 Hosting's public filings with securities regulatory authorities.For further information: For investor inquiries please contact: Nick Hurst The Equicom Group +1 (403) 218-2835 firstname.lastname@example.com For media inquiries please contact: Marcela Peake PEER 1 +1 (604) 909-6428 email@example.com


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Senator Andrea Stewart-Cousins poses with Yonkers Boy Scout Troop 5 (sponsored by Bryn Mawr Presbyterian Church) and Pack 338 (sponsored by St. Bartholomew's School in Yonkers).
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License. Permissions beyond the scope of this license are available at http://www.nysenate.gov/copyright-policy. NYSenate.gov is powered by Drupal.


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February 13, 2012
History Professor Katherine Parkin was featured on Slate.com on 2/13.
February 10, 2012
Hettie V.
Williams, lecturer of African American history, was featured in the Asbury Park
Press on February 10.
Dean of the Honors School Kevin Dooley's op-ed was published
in the Asbury Park Press on February 10.
Monmouth University Veterans Association Annual Care Package Drive and Dunk Tank
School of Science's book donation project helps support our science faculty and student colleagues at Bindura University of Science Education (BUSE) in Zimbabwe.
February 07, 2012
Lecture on Children and Cults will be held in Wilson Hall.
January 31, 2012
Children and Adults will read
literature by African American Authors
January 27, 2012
In celebration of Black History Month, Monmouth University is hosting a series of events programmed to celebrate African American heritage. Events are free and open to the public.
January 25, 2012
Many Universities Not Using Facebook as an Interactive Forum
The Monmouth University Debate Hawks will host the 2nd annual Jersey Shore Invitational Debate Tournament this weekend, January 28 to 29.
January 23, 2012
Psychology Professor Gary Lewandowski Was Mentioned in an Article on Slate.com on January 20, 2012
Monmouth University Professor of Mathematics Bonnie Gold received the Twenty-Second Annual Louise Hay Award from The Association for Women in Mathematics (AWM).
Website Highlighted by the National Association of Anorexia Nervosa and Associated Disorders.
January 19, 2012
Monmouth University is pleased to announce that its second phase of the Hawk Walk Brick Campaign has raised $32,982 for students.
Sociology Professor Nancy Mezey and Communication Professor Marina Vujnovic were featured in the Asbury Park Press and the Daily Record on 1/16.


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Matthew R. Rauth
Main Address:
Little River, SC 29566
Matthew Rauth is a PGA Professional in Little River, SC. The PGA of America comprises 27,000 men and women professionals with one singular goal in mind - to make the game of golf more enjoyable for you.
Services Offered:
- Instruction
Professional has not entered award information.
Home » Golf Courses » South Carolina » Little River » Matthew R. Rauth


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Gotta love the twitter.
"Kuo said:That twitter post is fairly old...<_< >_> ;D"http://twinkle.s3.amazonaws.com/s_1234296484443062.jpg"That's creepy dude."
- Forum Posts: 16508
- Wiki Points: 0
- Followed by: 418
- Reviews: 1 Lists: 4
"LiquidPrince said:O_o"Except Russel Peters."Russel Peters: Hate that mutha fucka too."
Okay well... Fail?
"geez, then i wont post anything >.<"nah im messin with ya!
Not sure about the other guy though...
Yeah im gunna call it quits, i guess it wasn't up any earlier this week, 3 am is over the top for me.
See you all another time!
- Forum Posts: 4008
- Wiki Points: 906
- Followed by: 74
- Reviews: 8 Lists: 10
IT's UP!
- Forum Posts: 1526
- Wiki Points: -1
- Followed by: 30
- Reviews: 0 Lists: 2
- Forum Posts: 1229
- Wiki Points: -1
- Followed by: 19
- Reviews: 3 Lists: 1
i watch tv and drink
Dare i say this weeks podcast was on the disappointing side? well maybe that is just me.
- Forum Posts: 379
- Wiki Points: 0
- Followed by: 20
- Reviews: 0 Lists: 3
Does anyone else try to save it for school/work?
It sucks cause I have nothing else to do right now
..as you can tell I really want to play that game.
Man, when abouts does the Podcast usually go up? I'm in England so am usually asleep before it gets posted, but now I'm staying up and it's like 4am >_<;
"YO FIFTY HEY FIFTY YOU WANT A BJ FIFTY U JUST LET ME KNOW FIFTY AYEITT..as you can tell I really want to play that game."lol, that video review was hilarious.
"Vinny is a sexy man."
- Forum Posts: 1124
- Wiki Points: 272
- Followed by: 91
- Reviews: 2 Lists: 5
It goes up at all different times. Hopefully it'll be up in the next few minutes but no one knows. It would be nice if they made a specific time.
JJOR, you just made my day.
"How have I never seen this before!
Something to watch while we wait.
My life is now complete :)
"that was unbelievable.
Something to watch while we wait.
"JJOR64 said::O"that was unbelievable. "
Something to watch while we wait.
I'll usually try to listen to other podcasts. I listened to The Hotspot a few hours ago... and that's pretty much it. There used to be a buttload of podcasts on Tuesday nights I could listen to, but now I'm pretty much down to The Hotspot and then waiting around for The Bombcast.
I've set up camp in the bombcast comments instead today...no idea why!
"How long should it take until it is uploaded onto iTunes?"