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Ash leads Texas over Cal 21-10 in Holiday Bowl
"We had our chances and gave the ball away," Tedford said.
Cal fumbled six times, losing four. The other turnover was an interception by Quandre Diggs, the younger brother of former Texas star cornerback and current San Diego Chargers starter Quentin Jammer.
"They did a good job of stripping it. They got it out today," Tedford said. "They got their hands on the ball, their hats on the ball and stripped it. There's really no explanation for something we've worked on."
Maynard was under pressure the whole game.
"We kept getting caught in second-and-long, third-and-long," the QB said. "It's hard to build a decent pass game and run game. ... It's hard to overcome those turnovers. It's hard to build momentum."
The Associated Press


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1 Bring 1 quart water to a boil. Add hibiscus and sugar, stirring until sugar has dissolved. Reduce heat and simmer for 10 minutes.
2 Remove from heat. Add remaining quart of water. Strain into a pitcher and chill.
3 To serve, pour into a glass filled with ice and garnish with citrus slices.


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Evening Walk to Piel IslandToday
Join us on a guided walk across the sands from Walney Island to Piel Island
Summer ClassicsToday
Choral and Orchestral Classics with a finale performed by more than 130 musicians.
The Proclaimers Live05/07/2015
This weekend at the Forum 28 - not to be missed.
Pie Night07/07/2015
On Tuesday's The Queens Arms hold their pie nights so come along!
Abbey Musical Society Summer Show07/07/2015
A fun filled evening of song and dance for all the family!
Steak Nights!08/07/2015
Come along to The Queens Arms and try one of their delicious steaks!
Knit and Natter08/07/2015
Ford Park are holding a Knit and Natter group so come along!
Ulverston Business Alliance 6th Birthday09/07/2015
Fancy a knees up in a brewery? Ulverston businesses celebrate as UBA turns 6
Bite-sized Archaeology & Flint-knapping12/07/2015
Celebrating the 2015 Festival of Archaeology, Morecambe Bay Partnership will be hosting a special day of hands-on archaeology at Barrow's Dock Museum
Intensive Bank Analysis15/07/2015
A three-day case study based workshop for credit risk, fixed income, origination and regulatory professionals. This course offers an in-depth analytic approach to the credit analysis.


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number-one New York Times best-selling author John C. Maxwell believes that any setback, whether professional or personal, can be turned into a step forward when you possess the right tools to turn a loss into a gain. Drawing on nearly fifty years of leadership experience, Dr. Maxwell provides a roadmap for winning by examining the eleven elements that constitute the DNA of learners who succeed in the face of problems, failure, and losses.
1. Humility - The Spirit of Learning
2. Reality - The Foundation of Learning
3. Responsibility - The First Step of Learning
4. Improvement - The Focus of Learning
5. Hope - The Motivation of Learning
6. Teachability - The Pathway of Learning
7. Adversity - The Catalyst of Learning
8. Problems - The Opportunities of Learning
9. Bad Experiences - The Perspective for Learning
10. Change - The Price of Learning
11. Maturity - The Value of Learning
Learning is not easy during down times, it takes discipline to do the right thing when something goes wrong. As John Maxwell often points out - experience isn't the best teacher; evaluated experience is.
©2013 John C. Maxwell (P)2013 Hachette Audio
"Good book for reflecting, bad narration"
No. I've heard Maxwell narrate a number of his own books and this does not capture the reflection I'd expect. I feel like the meaning is diminished or changed as a result.
Good things to reflect upon.
No - found it quite distracting.
Chapter on humility.
"i can read this book over and over!"
yes, its inspiring. you always learn, no matter what happens you learn, its about changing the attitude.
"Good advice."
The book is full of modern and old wisdom. This book is useful in many different parts of life,that have nothing to do with business.
"Good Book, Great Education"
Maxwell is by far by my favorite author. Pushing myself into the corporate world at the age of 18, was difficult to say the least. I am now 20 years old and managing mutual funds for a living. John taught me that it isn't always going to be easy, but it will be worth it. I've heard him speak dozen's of times, and never miss a book! Thanks for all of the hard work you put in John. Keep em' coming!
Hands down the story of the little girl in the Holocaust... Truly is unbelievable.
Never heard Chris Sorenesen perform before, wasn't bad at all!
"Need for personal therapy "
I needed this book to help me understand my set back. must read for everyone.
I loved this book so practical and easy to listen to. Will listen to it again
Realtor, mom, marathon runner, animal lover!
"Loved it!"
Enjoyed this audiobook thoroughly. In business, it's true, that there aren't many teachings on how to lose, which is inevitable. This audiobook was encouraging. Relatable stories, and great quotes! Found myself pulling to the side of the road to write things down!
Highly recommend and will be listening to more John Maxwell.
"I don't like the narration, but excellent book!"
See above great book awful voice and it's also annoying you can't leave short reviews to get them submitted agh.
"Learn Everyday From Yourself"
Making conscious efforts to learn from your shortcomings, failures, challenges and unconscious mistakes is a school on its own. Invest in your money; buy this book.
"It was on point"
It did exactly what I thought it would. Refreshed my motivation and kept me full of can-do power.
And as you know, John can trusted to not come from some crazy pop-psychology angle, only solid teaching.
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Average Customer Review
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Most Helpful First | Newest First
5.0 out of 5 stars a wonderful start!(start clapping...NOW!),
By A Customer
This review is from: Deltora Quest #1: The Forest of Silence (Paperback)
Okay, I'll admit, I am absolutely right about it being a wonderful start, but you'll have to pledge with all your heart that you're going to read through the entire thing in order to read through the entire thing, but I didn't do that, but there's a lot in the beginning that were of interest to me, constantly( go hmmm...NOW ).
First of all, the beginning gives you a lot about ancient mythology that will captivate your mind, and the history of everyone will not only give you squat on everyone's personality, but it'll show you how they were brought up, you might not know their personalities--yet, but I promise you, starting with the characteristics is going to help.
Now, if you read a lot of Emily Rodda, you can see that she styles her novelettes as a puzzle, you will find various riddles and quizzes amoungst the books, not neccessarily this one. But lets explore her world.
In the beginning, you find out how Leif discovered the reality behind the illusions, or a little after the beginning. Then the adventure starts. This part really moved my heart, where a boy who had lived in a palace all his life, finally meeting a humble shoemaker, and proves himself worthy of the trade after being mocked. Now, let's look at this book as a map.
Put an X on the scene I've just mentioned, mark that as an X for the start. Then, you move along as Leif discovers that all his life, the truth had been hidden from him and the prince. Surprise, surprise, the fairy just told Lief to follow the yellow brick road!
Soon, you hit shockwave as the castle had been attacked, the traitor is discovered, yet not discovered. Boo hoo, Lief just found out about the witch. Then terror goes around as the reader is informed about Barda, or the scarecrow, does that mean Lief is well on his way? Yes! Then, as havoc reaks in Deltora, Lief and Barda reaches The Forest of Silence. Having reached a miserable day, Lief and Barda are trapped( you see how well Emily Rodda lays the trap, she carefully organizes the characters' characteristics first to get the reader entranced on the novel, and then show their personalities as they move along, to secure her hold upon the reader. Classic, classic ), but in comes a spunky, flexible girl, who releases them, now we are introduced to the lion, mean at first, and then his heart spills out. Ah, as Dorothy faces a witch, Lief, Barda and Jasmine faces much more. Will they survive? Read this book along with the rest of the series to find out!
5.0 out of 5 stars Is This Book Great?,
By A Customer
This review is from: Deltora Quest #1: The Forest of Silence (Paperback)
Well, I should say, this book was great, I couldn't get my hands off of it and I'm still reading it. I just want to convince Ms. Rodda to make a ton more books because this is an itching book, like you don't want to stop and want to find out what is coming up next, that's why I'm constantly wanting to read it. Since I have baseball three to four times a week, I can't read as much as I use to.
This book was exciting and adventurous, but also life threatening. I want to read another one. This book is also likeable because it also teaches some things to you about life and how you should handle things. Even if it's dangerous or nervracking.
The characters seemed good together because they all seemed like friends or family because they all have their laughs and adventures sometimes. They also are romantic seeming that Jasmine and Lief like each other,but they don't know that they like one another. But then it was weird to find out that Lief was the heir of the thrown and became king.
Now, for me to type this much, it gives you a pretty good description on how much I enjoyed this book.
4.0 out of 5 stars the Deltora series: Great Books for Non-Bookworms,
Dale A. Favier (Portland, OR United States) - See all my reviews
This review is from: Deltora Quest #1: The Forest of Silence (Paperback)
This is a particularly good series for bright kids who are not born bookworms (although bookworms will probably love it too). The plots are intricate, but the prose is very simple and clear. There's lots of action and dreadful monsters to be fought: but there are also little puzzles, riddles sprinkled throughout the book, and many trick names which are significant if you pay attention to their sound rather than their spelling, or are anagrams, or have sinister double meanings. The adventurers find signs and symbols (illustrated in the book) that they have to puzzle out. All this appeals immensely to mathematically- or visually-inclined kids.
The moral world of Deltora is, of course, black-and-white, as befits the genre. Most of the bad guys are bad through and through, and most of the good guys are good through and through. But that doesn't mean that the books encourage a simplistic judgmental viewpoint. There are also people who seem bad but turn out to be good, and seem good but turn out to be bad. Many of the worst villains are shown to have been acting under various kinds of duress, disappointment, or obsession: some are rehabilitated. Also, although there's enough derring-do and fighting for the most dedicated comic book reader, there are also a surprising number of sticky situations that the heroes get out of by using their wits, sensitivities, and compassion. And each of the three has a slightly different moral "take" on the world, born of their varying experiences of it.
The series is mercifully un-sexist. The character of Jasmine, a wild girl who grew up alone in the forest, and can speak to trees, is as intrepid, skilled in fighting, and resourceful as her two male comrades, and she is often shrewder and more sensible. Monsters, wondrous creatures, heroes, villains, and faint-hearts, all generally come in two genders, with no fuss being made of it.
These books probably don't quite qualify as "classic fantasy," but they are among the very best of the second rank. I was very happy to find them, and my kids love them. If yours like these, go for the "Rowan of Rin" series by the same author, which is aimed at a slightly older, more thoughtful audience, and which I like even better.
5.0 out of 5 stars The Forest of Silence,
By A Customer
This review is from: Deltora Quest #1: The Forest of Silence (Paperback)
May I just start off by saying that th Forest of Silence is a winner for both sexes and all ages! This book is the beginning of a famous fantasy series. If you want to become a fan of fantasy, this is a book to start with. This captivating book centres around a group of travelling people trying to save the world from the grip of the feared Shadowlord who is terrorising the world. Even though it is not such a hard or serious read, you will instantly be reminded of Sauron and the Lord of the Rings. The suffering world has one last hope... the gems of the belt, which is in possession of Lief, the main character. So as you can imagine, while Lief travels the world in this series, he must uncover the gems to stand a chance against the Shadowlord! Then he has to face the Shadowlands...
If you've never considered reading as a fun thing, or are in desperate need of an easy novel with the thrilling contents of a normal-sized novel, or really need an introduction to novels, or love dark, exciting fantasy books...The Deltora Quest series will enthrall you, I promise.
5.0 out of 5 stars The Forest of Silence,
By A Customer
This review is from: Forest of Silence (School & Library Binding)
I think the Forest of Silence was a great book. It had a lot of action and excitement. It was about a boy and his best friend. One of the boys is the son of the king. The king died so his had to take the throne. Later the Belt of Deltora was stolen and shattered all over the Island to seven places. The belt of deltora protected the kingdom from evil, but with all seven gems shattered from the belt the kingdom was in danger unless the gems were on the belt again. The best friend moved to the town. Then the best friend sent his son and one of his friends to get the gems. They went to the forest of silence, but it was very dark. They met a lady that helped them. It took them a long time until they saw a person in a knight's armor with the gem at the bottom of the sword but he was not guarding the gem he was guarding something that makes you live forever. The lady went somewhere else. Then the knight told them that when the plant blooms stuff comes out and when you drink it you live forever. Then they started to fight but then the friend got stabbed. The son was about to get stabbed when the tree fell on the knight. The plant started blooming, he drank a little and it healed his wound. He does not live forever though. Read The Forest of Silence.
5.0 out of 5 stars A must read for young fantasy fans,
Erika Soeterik (Auckland, New Zealand) - See all my reviews
This review is from: Deltora Quest #1: The Forest of Silence (Paperback)
In the Ancient Past of Deltora, the seven tribes were united under the leadership of Adin and he crafted a belt to hold the seven talismans of the seven tribes. When the final talisman was added to the belt, the tribes were able to defeat the Enemy from the Shadowlands. Centuries later the Royal Family has weakened and then the Enemy from the Shadowlands takes control of Deltora. In a time of darkness and fear, the unlikely heroes - Lief and Barda - join forces to find the hidden talismans and to reunite the people of Deltora to throw out the evil invaders.
This series of eight books is brilliant for readers of all ages. I have noticed that this series of books is always out in the childrens section of the library that I work at - and that parents are just as keen to read these books as their children. I started reading the first book to get an idea of what the writing was like and then read the rest the books as soon as they came out.
Emily Rodda is a brilliant writer who combines action, adventure and magic into a world that is very real. This book will appeal to boys and girls, and if you like fantasy then you have got to read this book! (no matter ow old you are) I have just gotten hold of the first book in the trilogy that follows this series and can't wait to see how it compares.
If there is just one book you want to try this month then it has to be the first book in this series - I garuntee that you will be looking for the rest of the series by the time you reach the end of this one. If I could give this book six stars then I would.
5.0 out of 5 stars Can Lief and Barda save their land from the evil Shadowlord?,
Clarissa (Harvey, LA Harvey) - See all my reviews
This review is from: Deltora Quest #1: The Forest of Silence (Paperback)
Jarred and Endon, the prince of Deltora, have been friends for as long as they can remember. So when Jarred suspects that the Shadowlord, an evil that was defeated hundreds of years ago, has started to rise again, he insists that Endon, who has been made king after his parents mysterious deaths, to do something. He wants Endon to start wearing the Belt of Deltora, a belt that has seven powerful gems on it and is the only thing powerful enough to stop the Shadowlord, but the king is only allowed to wear it at his coronation. Endor's advisor convinces him that Jarred is a traitor and Jarred is forced to leave the palace grounds. But years later it turned out that Jarred was right and Endon calls for his help. Once Jarred returns to the castle they go to look for the belt and discover that the gems have been removed and scattered in the seven most terrifying places in Deltora. Endon and his wife are forced to go into hiding to protect their unborn child, who is also the only one who will be able to wear the belt. Sixteen years later, Jarred's son, Leif, has accepted the task of finding the gems and saving his land. And the first stop on his list is the Forests of Silence, a place so feared that even saying the name would invoke terror into all who know of it. But Lief has help, a man named Barda who used to be a palace guard before the Shadowlord came. But will the both of them be strong enough to finish their task? This book was a great start to a new eight-book saga that will be filled with adventure.
5.0 out of 5 stars One boy must save an entire world from the grip of evil.,
Rebecca Herman (USA) - See all my reviews
This review is from: Deltora Quest #1: The Forest of Silence (Paperback)
As a child growing up at the palace, Jarred was servant, companion, and only friend to the young prince, Endon. And as a teenager, Jarred was the only one who suspected the truth behind the sudden deaths of the king and queen. But Endon, now king, ignored Jarred's warnings, and allowed his advisors to banish Jarred. Several years later, Jarred discovers his worst fears were all true - Endon's closest advisor was a traitor, orchestrating behind the king's back the takeover by the evil Shadow Lord of the kingdom of Deltora. With Jarred's help, Endon and his wife, who is pregnant with the heir to the throne, flee, with Jarred vowing to someday return them to their rightful throne. Years later, on his sixteenth birthday, Jarred's son Lief learns the task to free Deltora from the Shadow Lord's power has fallen into his hands. Now it's up to one young boy to save an entire world. Is Lief strong enough for the enormous task that lies ahead? This book was the thrilling beginning to an eight-part fantasy saga. I can't wait to read the rest of the books in the series.
5.0 out of 5 stars The Quest Begins,
nazim (sydney, nsw australia) - See all my reviews
This review is from: Deltora Quest #1: The Forest of Silence (Paperback)
The Forests of Silence is the first book of the much loved deltora quest series- a story of magic, monstes and mindbenders. The basic plot of the story is that the great belt of deltora- the lands magical defense- is destroyed. Lief, a young boy of 17 must travel throughout the land of deltora, seeking the great jems of the belt, and thus restore the belt.
The first jem,the golden topaz, is hidden in one of the three Forests of Silence. These forests are inhabited by all maner of deadly beasts, and guarded by the most powerful of the them all, is the prise they seek.
Forests of silence is a good book, riddled with pictures, puzzles, magic and monsters. Emily roddar is espicially vivid with her descriptions, and the story is very imaginative. But the thing i like most in this story are the puzzles and pictiures littered throughout the storey.
Something else that deserves a look in is the wonderful front cover. Absolutely superb, to say the least.
5.0 out of 5 stars The Forests of Silence, The begining of a fantastic series.,
This review is from: Deltora Quest #1: The Forest of Silence (Paperback)
Deltora Quest's first book, "The Forests of Silence" is a very intense and suspenseful book. The Deltora Belt that protects the land of Del has been broken. The seven stones that power the belt have been scattered across the land in places that no one would even try to find them. Lief and his not so happy companion Barda fight their way to the topaz stone with the help of their new friend, Jasmine. Lief, Barda, and Jasmine are the only hope to rid the land of the Shadow Lord. It is up to them to return the Belt back to the King. You will be at the edge of your seat as you read about Lief and Barda getting jumped by ugly Wenns that sting and paralyze you. You will be shocked as you read about Lief and Barda fighting an evil knight and escaping from scary, mystical creatures. I think that this book is exciting, thrilling, suspenseful, and good for all ages. I would recommend this book to anyone who is interested in fantasy.
Most Helpful First | Newest First
Deltora Quest #1: The Forest of Silence by Emily Rodda (Paperback - April 1 2001)
Used & New from: CDN$ 0.01


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"We don't even really think about most cancers until at least 10 years after a toxic event but we are already seeing an increase here that is at or approaching statistical significance. This is the first clue that cancers might be elevated in this population," Crane told me.
Once you sign up for the fund, you have two years to complete your filing. The process is daunting. It involves an examination by a doctor affiliated with the World Trade Center Health Program, submission of detailed medical records and medical bills, employment records, and affidavits from various people who can vouch for your whereabouts on 9/11 and the following year.
Filing the complete claim can take up to two years and Schwartz said most claimants won't see any money for at least 18 months after that. As of now, just 53 claim decisions have been made by the fund.
That is why even if you aren't currently ill, I urge you to sign up for the compensation fund before time runs out. If you think you are eligible, this is a critical step you can take to protect your rights to collect health care and other benefits in the future.
It's too late to request the forms by mail but several options still exist to file before the Oct. 3 deadline. You can find out more by following this link.


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Well, let's see. My Honda's both got well over 150,000 miles and I would have definitely gotten more if I didn't want to get a newer model. The most I ever got out of an American car through the years was 120 max and that was only one car.
Blown tranny's, blown engines and various other problems along the way. Like I said, Americans would be willing to buy Detroit's product if it had equal to or better quality than a decent foreign automobile...oh, and one other point-vastly superior gas mileage. This is exactly why foreign automakers have been eating their shorts IMO.
I have two newer American cars and both are over 110,000 miles with no major issues. Simple maintnence that is all.
There's no such thing as a pretty good aligator wrestler.
Should be a required read for anybody who wants to blame "greedy unions" or "incompetant management" for the demise of the Big Three.
Some of the numbers are astounding:
In 1962, G.M. had four hundred and sixty-four thousand U.S. employees and was paying benefits to forty thousand retirees and their spouses...Last year, it had a hundred and forty-one thousand workers and paid benefits to four hundred and fifty-three thousand retirees
The American manufacturing operations of Toyota, [has] a mere two hundred and fifty-eight retirees
Companies are already abandonning traditional pensions for 401K's it would seem the next step is to eliminate company sponsored health care.
We have a 1997 Ford Explorer w/ 190,000 miles on it and a 2001 Ford Escape with 140,000. We bought them both new and maintained them well.
"All my life I have tried to pluck a thistle and plant a flower wherever the flower would grow in thought and mind." -- Abraham Lincoln
Running at just over 200,000 on my Crown Vic - thinking about getting something new and turning this over to one of my kids. I figure it will go another 100,000.
R.I.P. Cyrano and Roxanne.


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Gear Review
Sam Dickerson
Good Cookset
- Gender: Male
- Familiarity: I've put it through the wringer
This cookset is a good one. The pot heats water well, and it cleans easy with the non-stick coating, however i usually just boil water in it. The coated handle on mine melted a little bit when I cooked over an open fire. The provided spork is flimsy, and it is easy to jam your thumb pretty good. I really like the bowl, and the provided sleeve. The pot lid can also be used tupperware-style and keeps food and stuff from spilling in your camp while youre looking for something in your camp. It stores a Snow Peak Gigapower and an MSR fuel bottle easily, even with bowl and spork. I dont use the stuff sack, but I image it serves its purpose.
View More Details on GSI Outdoors Pinnacle Soloist Cookset


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Make a guess! We'll include everything from Thursday night to Sunday night, judging by the actual weekend numbers that are posted on Box Office Mojo on Tuesday. Whoever gets closest will get something stupid (probably some Screened stickers or something equally slight).
I'm going to go ahead and guess $185 million. Less than The Avengers, but a lot of money nonetheless.


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i posted the other day with a question regarding what gear to bring in my pack. ..assuming i would be using a backpack. and now i've been thinking, sould i use a backpack, or go for the rack and trunk bag?
my backpack is well ventilated and holds 1700 ci's. i 'm definitely not going to pack it full, but i'm still worried about having all the weight on my back since the ride is about 1/3 singletrack. so i'm thinking about something like this rack http://harriscyclery.net/page.cfm?Pa...ils&sku=RK7000 since i don't have the eyelets for a regular rack on my bike. with a 700 - 900 ci trunk bag, a frame bag on the front of my frame, and my normal sized hydration pack, i think i could fit all the stuff i would have packed in my larger pack. this would spread the weight around a little bit and take most of it off my back.
does this sound like a good idea? the possible complications off the top of my head are:
- the possibility of the rack swing from side to side (would have to make a few test runs to prove/disprove/address this)
- the trunk bag sitting so high that i can't hang my butt off the back of the seat on steep descents
- weight on rack sitting so high that it affects the center of gravity of the bike
anybody haver any thoughts or experiences? i think i'll post in the mtb forum too. thanks.


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Ryan "now 25" finally began hitting off a tee yesterday but where does the once "highly praised" prospect end up from here? I'm not sure how everyone else feels but outside of some nice plays in the OF when he first came up and decent minor league numbers Ryan never really seemed to grasp big league pitching.
If Ryan stays healthy do still feel he can still break into our lineup in the next couple of years, he is only 25? Or, Should we package him if the stock rises again in fear he may continue to be injury prone?


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Originally written on Fox Sports Wisconsin | Last updated 1/14/13
February 09, 2010 Milwaukee, WI. Bradley Center..Milwaukee Bucks Brandon Jennings had 18 points and 5 assists..Milwaukee Bucks lost to the Detroit Pistons 81-93. Mike McGinnis/CSM.
Getty Images
Following a week that featured two of the best games of his season, Bucks point guard Brandon Jennings has been named the NBA's Eastern Conference Player of the Week. Jennings - who also won the award following the opening week of the season - averaged 24.5 points and 6.5 assists per game while shooting 47.7 percent and 50.0 percent from three. This is the third such honor in his career. Following the departure of coach Scott Skiles, Jennings exploded in back-to-back games against Phoenix and Chicago. Against the Suns, Jennings led the Bucks with 29 points and dished out nine assists while connecting on five of his seven three-point attempts. The next night in Chicago, the 23-year-old point guard scored 20 of his season-high 35 points in the third quarter, helping Milwaukee rally past the Bulls. After scoring 15 points against Detroit on Friday, Jennings finished his week scoring 19 points with 10 assists in Sunday's win over Toronto. Bucks guard Monta Ellis also won the award for t...
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Viewers: in countries Watching now:
In this course, Pulitzer finalist Natalie Fobes shows how to capture engaging portrait shots of couples, families, and other groups using a variety of posing and composition techniques.
The course discusses how to plan for a portrait photo shoot and how to make stylistic decisions regarding props, clothing, and makeup. Next, the course reviews the essentials of posing women and men, starting with a single subject, moving on to a couple, and then working up to large groups. The course also demonstrates how to pose and compose a group portrait in ways that highlight the relationships between group members, whether they're family members or business colleagues. Lastly, to illustrate the time constraints photographers often face, Natalie works against the clock to shoot a group of people she's never met.
The course also covers various postprocessing techniques geared specifically for portraiture, such as working with wrinkles and skin textures.
In this course I've shared tips and techniques that I've learned over my career. Now it's your turn. The main thing to remember when shooting group shots is that you are the one in control. You make all the decisions about location, lighting, and poses. And don't worry, it gets a little bit easier with experience. So good luck and good shooting!
There are currently no FAQs about Family and Group Portraiture.
Access exercise files from a button right under the course name.
Search within course videos and transcripts, and jump right to the results.
Remove icons showing you already watched videos if you want to start over.
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text:
The invention relates to a new ultrasound contrast agent of the type which relies on microbubbles for echogenicity. The new contrast agent comprises microbubbles with an internal atmosphere enhanced with a perfluorobutane gas which is effective for visually detecting myocardial uptake upon echocardiogram following peripheral intravenous injection of said agent into a host. The contrast agent of this invention is unique in that it makes possible the non-invasive visual detection of myocardial uptake. In addition, the contrast agent of this invention makes feasible safe and consistent, non-invasive methods for visually assessing, qualitatively or quantitatively, not only myocardial perfusion, but renal and hepatic perfusion, and for detecting severity of coronary arterial stenosis.
1. A pharmaceutically acceptable ultrasound contrast agent which relies on microbubbles for echogenicity, said agent comprising:
microbubbles formed from a solution of a filmogenic protein and a saccharide wherein said saccharide comprises less than about 40% by weight of said solution wherein said microbubbles have an internal atmosphere enhanced with perfluorobutane gas.
2. The contrast agent of claim 1 wherein said filmogenic protein is human serum albumin.
3. The contrast agent of claim 2 wherein said human serum albumin is diluted 2 to 8 fold with dextrose.
4. The contrast agent of claim 3 wherein said human serum albumin is a 5% by weight solution.
5. The method of claim 4 wherein said dextrose is a 5% by weight solution.
6. The contrast agent of claim 1 wherein said saccharide is dextrose.
7. A sonicated aqueous albumin-dextrose ultrasound contrast agent solution comprising:
between about a two-fold and about an eight-fold dilution of aqueous albumin with between about 5% to about 50% by weight aqueous dextrose solution;
said albumin between about 2% to about 10% by weight solution; and
microbubbles the gaseous content of which contain an amount of perfluorocarbon gas which is effective for visually detecting myocardial perfusion upon echocardiogram following peripheral intravenous injection of said agent into a host.
8. The contrast agent of claim 7 wherein said dilution of albumin with dextrose is a 3-fold dilution.
9. The contrast agent of claim 8 wherein said human serum albumin is a 5% by weight solution.
10. The contrast agent of claim 8 wherein said dextrose is a 5% by weight solution.
11. A method for myocardial, renal or hepatic opacification comprising the steps of:
(a) obtaining an echo contrast agent solution which comprises:
(i) forming an aqueous albumin-dextrose solution containing between about a two-fold and about an eight-fold dilution of between about 5% to about 50 by weight dextrose and between about 2% to about 10% by weight human serum albumin, and
(ii) sonicating said mixture to form microbubbles the gaseous content of which contain an amount of perfluorocarbon gas which is effective for visually detecting myocardial perfusion by echocardiogram following peripheral intravenous injection of said agent into a host;
(b) introducing said echo contrast agent into a host by intravenous injection; and
(c) performing an echo contrast study on said host using a suitable Doppler or ultrasound echo apparatus.
12. A pharmaceutically acceptable contrast agent which relies on microbubbles for echogenicity, said agent comprising:
microbubbles with an interior atmosphere enhanced with perfluorobutane gas.
13. A pharmaceutically-acceptable ultrasound contrast agent which relies on microbubbles for echogenicity prepared by the method of:
combining a denaturable protein and a saccharide to form a solution wherein said saccharide comprises less than about 40% by weight of said solution;
perfusing said solution with fluorobutane gas;
sonicating said solution during said perfusion so that microbubbles are formed with an internal atmosphere comprising said perfluorobutane gas.
14. The method of claim 13 wherein said saccharide is dextrose.
15. The method of claim 13 wherein said protein is human serum albumin.
This application is a continuation-in-part application of U.S. patent application Ser. No. 08/252,286 filed by Thomas R. Porter on Jun. 1, 1994 and now U.S. Pat. No. 5,567,415, which is a continuation-in-part application of U.S. Ser. No. 08/301,146 filed by Thomas R. Porter on Sep. 6, 1993 and now U.S. Pat. No. 5,578,291, which is a continuation of U.S. patent application Ser. No. 08/113,415 filed by Thomas R. Porter in Aug. 27, 1993 and now abandoned, which is a continuation-in-part application of U.S. application Ser. No. 08/060,751 filed by Thomas R. Porter on May 12, 1993 and now abandoned, which is a continuation-in-part application of U.S. patent application Ser. No. 08/057,298 filed by Thomas R. Porter on May 4, 1993 now abandoned. All of said applications are commonly owned.
This invention relates to a new and improved ultrasonic contrast agent and to its manufacture and use in ultrasonic imaging and echocardiography. More particularly, the contrast agent of this invention relates to the sonicated microbubble type, but is unique in that it makes possible the non-invasive visual detection of myocardial uptake, as discussed more fully hereinafter. In addition, the contrast agent of this invention makes feasible safe and consistent, non-invasive methods for visually assessing, qualitatively or quantitatively, not only myocardial perfusion, but renal and hepatic perfusion, and for detecting severity of coronary arterial stenosis.
Ultrasonic imaging is used as a diagnostic tool to aid in therapeutic procedures. It is based on the principle that waves of sound energy can be focused upon an area of interest and reflected to produce an image. Generally, an ultrasonic transducer is placed on a body surface overlying the area to be imaged, and ultrasonic energy, produced by generating and receiving sound waves is transmitted. The ultrasonic energy is reflected back to the transducer where it is translated into an ultrasonic image. The amount and characteristics of the reflected energy depend upon the acoustic properties of the tissues, and contrast agents which are echogenic are preferentially used to create ultrasonic energy in an area of interest and improve the image received.
In ultrasound imaging, videotape images obtained following contrast injection are digitized, allowing the gray scale to be quantified from 1 to 225 gray scale units for 30 cardiac cycles. The contrast intensity is plotted on the vertical axis against time on the horizontal axis. The peak videointensity (corrected for baseline intensity) is determined as the highest point on the time intensity curve.
For a discussion of contrast echographic instrumentation, see, for example, De Jong N, "Acoustic properties of ultrasound contrast agents", CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK, DEN HAG (1993), pages 120 et seq.
Contrast echocardiography has been used to delineate intracardiac structures, assess valvular competence, and demonstrate intracardiac shunts. Myocardial contrast echocardiography (MCE) has been used to measure coronary blood flow reserve in humans. MCE has been found to be a safe and useful technique for evaluating relative changes in myocardial perfusion and delineating areas at risk.
A multiplicity of potential ultrasonic imaging agents has been reported for contrast echocardiography. No such agent routinely attains visually discernible myocardial uptake following peripheral intravenous injection. Although there have been many reports of transpulmonary transmission of ultrasound contrast agents following intravenous injection and despite the fact that myocardial opacification on echocardiogram can be produced by left sided injection of such contrast agents, visualization of myocardial contrast has not been achieved by intravenous administration of sonicated microbubbles.
Most recently, sonicated albumin and sonicated dextrose/albumin have been shown to produce variable degrees of left ventricular chamber ultrasound contrast following intravenous injection. (See Villanueva et al. Circulation 85:1557-1564, 1992; Lin et al. Int J Card Imaging 8:53-6, 1992; Feinstein et al. J Am Coll Cardiol 16:316-224, 1990; Keller et al. Am Heart J 114:570-575, 1987; and Shapiro et al. J Am Coll Cardiol 16:1603-1607, 1990). The microbubbles of these contrast agents are small (4-6 microns) and are capable of swift transpulmonary passage. However, visually discernible myocardial uptake of such microbubbles following peripheral intravenous injection has not been possible because of the rapid diffusion of blood soluble oxygen and nitrogen inside the microbubble into the blood which consequently loses its ultrasound reflective properties (e.g., see Porter et al. J Am Soc Echocard Supplement 7:S1, May 1994, and Weyman AE: Principles and Practice of Echocardiography, Malvern, Pa.: Lea & Febiger, 1994; pp. 302-26.)
An important objective of this invention is to provide a contrast agent and methods for its production and use wherein microbubble survival and subsequent myocardial ultrasound contrast is improved sufficiently to make possible visually discernible myocardial uptake of such microbubbles following non-invasive peripheral intravenous injection. This and other objectives of this invention will become apparent in the following discussion.
In accordance with this invention, there is provided an improved ultrasound contrast agent which relies on microbubbles for echogenicity, which comprises enhancing the internal atmosphere of the microbubbles with an amount of perfluorobutane gas which is effective for visually detecting myocardial uptake upon echocardiogram following peripheral intravenous injection of said agent into a host. The perfluorobutane gas content of the microbubbles is sufficient to lower microbubble gas solubility and diffusivity in vivo in blood. Generally, the minimum amount of perfluorobutane gas in the microbubbles which is effective is that amount which results in microbubbles which pass reliably through the pulmonary circulation without collapse. This is evidenced by opacification of the myocardium of the left ventricle of the heart following intravenous injection and can be visually discerned by echocardiography, for example, in accordance with standard methods or the methods described more fully hereinafter.
Consequently, the invention also provides a method of ultrasonic imaging for use in medical procedures, comprising the steps of injecting the unique perfluorobutane-containing microbubbles of this invention into a host to thereby alter the acoustic properties of a predetermined area, and ultrasonically scanning an area including said predetermined area so as to obtain an image of said predetermined area.
The perfluorobutane-enhanced contrast agents of the invention comprise any contrast agent for ultrasonic imaging which relies on microbubbles for ecogenicity the interior of which are enhanced with perfluorobutane gas. The use of perfluoropropane gas (C3 F8) to enhance the internal atmosphere of microbubble contrast agents has been described in my previously filed and pending application U.S. Ser. No. 08/057,298 filed on May 4, 1993. This invention related to the discovery that perfluorobutane gas (C4 F10) or decafluorobutane results in much inproved contrast over traditional contrast agents and even over any perfluorocarbon gas contrast agent including perfluoropropane and perfluoropentane. Perfluoropentane is plagued by side effects as it is liquid a room temperature and once injected into the higher temperature of the body it tends to expand uncontrollably which can lead to increased pulmonary pressure and toxicity after ultrasound is completed.
Perfluorobutane (C4 F10) has been previously demonstrated as safe for intraocular injection in humans. It has also been used in human studies for intraocular injections to stabilize retinal detachments (Wong and Thompson, Ophthalmology 95:609-613) and is useful in treating complicated retinal detachments by providing internal tamponade of retinal breaks.
For most ultrasound imaging, the contrast agent is formulated in a pharmaceutically effective dosage form for peripheral administration to the host to be imaged. Generally such host is a human subject although other mammalian hosts, such as canine or equine can be imaged effectively. In a most preferred embodiment the contrast agent is a sonicated mixture of commercially available albumin (human), USP, solution (generally supplied as 5% or a 25%, by weight, sterile aqueous solutions), and commercially available dextrose, USP, for intravenous administration are employed. This mixture is sonicated under ambient conditions, i.e., room air, temperature and pressure, and is perfused with perfluorobutane during sonication.
In a preferred embodiment the invention uses a microbubble contrast agent wherein the microbubbles are stabilized by a filmogenic, de-naturable protein coating. Suitable proteins include naturally occurring proteins such as albumin, human gammaglobulin, human apotransferrin, Beta-lactose, and urease. The invention preferably employs a naturally occurring protein, but synthetic proteins may also be used. Particularly preferred is human serum albumin.
Although intravenous echo contrast agents made from sonicated microbubbles are known (e.g., ALBUNEX, Molecular Biosystems, Inc.) and can be employed in this invention, it is preferred to use a sonicated aqueous solution containing a mixture of a pharmaceutically acceptable saccharide, e.g., dextrose, and a protein, e.g., albumin. Generally, sonication is performed in an air atmosphere. In an especially preferred embodiment, dextrose, which is readily available in pharmaceutically acceptable dosage forms, is the preferred saccharide and human serum albumin is the preferred protein. The preferred embodiment would include a two-fold to eight-fold dilution of 5%-50% by weight of dextrose and a 2%-10% by weight of human serum albumin. Exemplary of other saccharide solutions of this invention are an aqueous monosaccharide solution (e.g. having the formula C6 H6 O12, such as, the hexoses, dextrose or fructose, or mixtures thereof), aqueous disaccharide solution (e.g., having the formula C12 H22 O11, such as sucrose, lactose or maltose, or mixture thereof), or aqueous polysaccharide solution (e.g., soluble starches having the formula (C6 H10 O5)n, wherein n is a whole integer between about 20 and about 200, such as amylose or dextran, or mixtures thereof. Sonication by ultrasonic energy causes cavitation within the dextrose-albumin solution at sites of particulate matter or gas in the fluid. These cavitation sites eventually resonate and produce small microbubbles (about 4 to about 7 microns in size) which are non-collapsing and stable. In general, sonication conditions which produce concentrations of greater than about 4�108 m of between about 5 and about 6 micron microbubbles are preferred.
The mean microbubble size of sonicated dextrose albumin ranges from between about 5 to about 6 microns. This is a good size as it has been observed that microbubble radius decreases as a function of time in a still liquid due to a diffusion gradient present between the internal and external gases of the microbubble. An increase in microbubble size has a significant effect on the persistence of a microbubble within blood. It must also be of a size sufficient for transpulmonary passage. It must have a mean diameter of less than 10 microns and greater 0.1 microns. Since the size of albumin microbubbles is ideal (between 5 and 6 microns) for transpulmonary passage, the major reason for the significant loss in left ventricular and myocardial videointensity produced following intravenous injection of albumin coated microbubbles is due to the significant diffusion of gases within the microbubble following intravenous injection during transit to the left ventricular cavity. Sonicated dextrose albumin enhanced with an inert gas such as perfluorobutane gas, having a lower blood solubility than air, produces a significantly higher left ventricular and myocardial videointensity than sonicated albumin alone.
In addition to myocardial imaging the contrast agents of this invention are useful for renal and hepatic imaging. Thus, another embodiment of this invention provides a method for myocardial, renal or hepatic opacification. The method preferred involves obtaining an echo contrast agent of this invention, introducing said echo contrast agent into a host by intravenous injection, and performing an echo contrast study on said host using a suitable Doppler or ultrasound echo apparatus as discussed more fully hereinafter.
The method of ultrasonic imaging in which microbubbles formed by sonicating an aqueous protein solution are injected into a mammal to alter the acoustic properties of a predetermined area which is then ultrasonically scanned to obtain an image of the area for use in medical procedures is well known (e.g., see U.S. Pat. No. 4,572,203, U.S. Pat. No. 4,718,433 and U.S. Pat. No. 4,774,958, the contents of each of which are incorporated herein by reference). It is the use of the unique, stabilized perfluorobutane-containing microbubbles of this invention which constitutes a novel improvement over even other perfluorocarbon gases. Thus, in accordance with another embodiment of this invention, there is provided a method of ultrasonic imaging for use in medical procedures comprising the steps of forming an aqueous protein solution (e.g., aqueous dextrose albumin), subjecting said solution to high frequency sonication while exposed to perfluorobutane gas, said sonication forming stabilized microbubbles of relatively uniform size, containing said perfluorobutane, and capable of transpulmonary passage, and using the stabilized microbubbles as an injectable contrast agent for said ultrasonic imaging.
Sonicated albumin has been used to study coronary flow reserve and immediate post-angioplasty anterograde blood flow reserve in humans. In humans without significant coronary artery disease, left main coronary artery injections of sonicated albumin before and after intracoronary papaverine result in time intensity curves which can be utilized to determine coronary flow reserve. It has been demonstrated that the washout of ultrasound contrast from the human myocardium in this setting correlates with coronary flow reserve measured by more invasive techniques.
Secondly, intracoronary sonicated albumin injections in humans with coronary artery disease, before and after angioplasty, has been done. The functional reserve of the myocardium supplied by the vessel undergoing angioplasty is immediately improved following angioplasty. The degree of improvement depends not on how visually successful the angioplasty was, but on how quantitatively successful the improvement in stenosis area was after angioplasty. Sonicated albumin does not reliably cross the pulmonary circulation into the left ventricular chamber following an intravenous injection, and thus at present cannot be used to non-invasively detect myocardial blood flow.
It has been observed that a microbubble radius decreases as a function of time in a still liquid due to a diffusion gradient present between the internal and external gases of the microbubble. An increase in microbubble size has a significant effect on the persistence of a microbubble within blood. The mean microbubble size of sonicated dextrose albumin ranges from between about 5 to about 6 microns. Since this size is ideal for transpulmonary passage, the major reason for the significant loss in left ventricular and myocardial videointensity produced following intravenous injection is due to the significant diffusion of gases within the microbubble following intravenous injection during transit to the left ventricular cavity. Sonicated dextrose albumin enhanced with an inert gas such as perfluorobutane, having a lower blood solubility than air, produces a significantly higher left ventricular and myocardial videointensity than sonicated albumin alone.
Because of high surface tension, the concentration of nitrogen and oxygen gas within the microbubble is much higher than that in blood, and thus there is a rapid diffusion of this gas into the blood stream following intravenous injection. Wible et al. (Circulation, 88:I-401, 1993) demonstrated that this diffusion process can be accelerated if one decreased the partial pressure of nitrogen within the blood stream by decreasing the inhaled fraction of nitrogen. This lower external concentration of nitrogen results in loss of the left ventricular videointensity produced by the same intravenous injection of sonicated albumin while inhaling room air. It has also been observed that oxygen rapidly diffuses out of gas bubbles into human blood (See Yang et al., J Biomech 3:275, 1971).
Both nitrogen and oxygen diffuse rapidly across these concentration gradients, but nitrogen appears to dissolve more slowly than oxygen into blood. Since nitrogen is the major component of air, decreasing the concentration gradient for nitrogen across the microbubble improves left ventricular and myocardial videointensity following intravenous injection. Exposing the microbubbles to a non-toxic gas having a lower blood solubility and/or microbubble diffusivity than that of nitrogen and having a gas density of greater than about 0.300 lb/ft3 during sonication increases the size and stability of the microbubbles in sonicated dextrose albumin, while lowering the solubility and diffusivity of the microbubbles in blood.
The most preferred contrast agent of this invention is a perfluorobutane-enhanced sonicated dextrose albumin solution comprised of a sonicated three-fold dilution of 5% human serum albumin with 5% dextrose. During sonication, said solution is perfused with perfluorobutane for about 80 seconds, which lowers the solubility and diffusivity of the microbubble gas. The resulting microbubbles are concentrated at room temperature for at least about 120�5 minutes, wherein the excess solution settles in the sonicating syringe. The excess solution is expelled and the concentrated microbubbles are transferred to a sterile syringe and injected intravenously into a mammal.
A second method or preparation includes hand agitatin 15�2 ml of sonicated dextrose albumin with 8�2 ml of a perfluorobutane gas prior to sonication. Sonication then proceeds for 80�5 seocnds.
Using perfluorobutane gas to enhance the sonicated contrast agent of this invention will result in a higher degree of myocardial opacification, endocardial border delineation, and enhanced detection of left-sided ultrasound Doppler signals, upon peripheral venous administration. Additionally, using perfluorobutane gas during sonication creates a more stable microbubble concentration, which subsequently enables ultrasonic visualization of the liver and kidneys following an intravenous injection.
The following examples demonstrate the effect of inert gases on microbubble stability and diffusibility, and the superior results of perfluorobutane as compared to other perfluorocarbon gases on myocardial uptake and videointensity as well as on ultrasonic determination of renal perfusion. In all the following examples all parts and percentages are by weight, unless stated otherwise. All dilutions are by volume.
Albumin (human) USP, 5% solution (hereinafter referred to as "albumin") and dextrose USP, 5% solution (hereinafter referred to as "dextrose") were obtained from a commercial source. The sonicating system used for sonication was a Heat System Ultrasonic Processor Model XL2020 (Heat Systems Inc., Farmingdale, N.Y.). The 1/2 inch horn transducer was a resonating piezoelectric device. The 1/2 inch sonicating horn tip was sterilized prior to each sonication.
Sixteen milliliter aliquots of albumin diluted 1:3 with dextrose were drawn up into a 35 cc "Monoject" syringe (Becton Dickinson and Company, Rutherford, N.J.) and sonicated for 80�1 seconds. The "Leur-Lok" of the 35 milliliter syringe was then attached to a stopcock. After mixing the dextrose albumin solution by hand for about 7 to about 10 seconds, the plunger was removed from the top of the syringe. The sterile sonicating horn was then lowered into the open end of the syringe until at the surface of the albumin-dextrose solution. The solution was placed at the horn tip and manually held at this position while continuously sonicating at a frequency of 20,000 Hz and a power output of 210 W for 80�1 seconds to form a stable microbubble solution.
During sonication, the dextrose albumin mixture was exposed to either perfluoropropane or perfluorobutane gas (Commercial Grade, 99.9% by weight). The gas was drawn up into a sterile syringe through a 0.22 μM filter (Micron Separations Inc., Westborough, Mass.) to prevent contamination. During sonication, 5 milliliters of perfluorocarbon gas was manually injected into the solution, over the 80 second time interval, through the stopcock so that the microbubbles produced contain this less soluble gas. The total volume of perfluorocarbon-enhanced sonicated dextrose albumin produced with this formulation was 25�2 milliliters. These samples were then used for intravenous injection.
Microbubble size and purity was determined using hemocytometry. Microscopic inspection of the microbubbles was performed to determine if any coalescent microbubbles were present in the solution. Microbubble concentration was determined using a Coulter Counter. The contrast agent was rejected for use if any of the following conditions are present: the mean microbubble size was 4.0 to 6.0 microns; coalesced microbubbles or strands were detected by light microscopy; or the mean microbubble concentration was less than 0.8�109 or greater than 1.5�109 microbubble/milliliter. The sample was also rejected if the number of microbubbles greater than 10 microns in the sample was greater than 4%.
All samples were stored in 35 milliliter syringes until time of injection. All solutions were given within 36 hours of production. All samples were prepared in a laminar flow hood.
Mongrel dogs of either sex (15-30 kilograms) were anesthetized with sodium pentobarbital (30 milligram per kilogram intravenously), intubated, and ventilated initially with room air using a positive pressure respirator. A left thoracotomy was performed under sterile conditions and the pericardium incised. In addition to a 19 gauge peripheral intravenous line, eight French Catheters were placed in the femoral artery and vein for intravenous administration of ultrasound contrast agents and pressure monitoring. Through one femoral venous sheath, a 7F balloon-tipped thermodilution catheter was placed in the pulmonary artery using fluoroscopy for determination of pulmonary artery pressure and cardiac output. A 7F pigtail catheter was introduced into the left ventricle for pressure measurements (left ventricular systolic and end-diastolic pressure) following injection of each ultrasound contrast agent.
Following adequate surgical exposure, a 3.5 Megahertz ultrasound transducer connected to a commercially available ultrasound scanner (Hewlett Packard Company; Andover, Mass.) was placed in a warm water bath. The bath overlays the anterior epicardial surface. The transducer was mounted on a clamp and lowered into the bath. It was adjusted until an optimal stable short axis view of the left and right ventricle had been obtained at the ventricular mid-papillary muscle level. These images could then be used to assess left ventricular cavity and myocardial uptake of contrast following intravenous injection.
Three open chest dogs were used to measure anterior and posterior myocardial peak videointensity produced by either a 0.015 or 0.03 milliliter per kilogram intravenous injection of DF-SDA. These values were compared with the videointensity produced in these same regions by a 0.06 ml/kg intravenous injection of perfluoropropane-enhanced sonicated dextrose albumin (PESDA). Left ventricular and pulmonary artery pressures were measured before and after injection, as well as cardiac output.
The degree of left ventricular cavity shadowing was significantly less with DF-SDA than with PESDA in 5 dogs. This was verified in Table 1, where the peak posterior myocardial videointensity produced with DF-SDA was significantly higher than that produced by PESDA. This was entirely due to the significant decrease of left ventricular shadowing. As can be seen in Table 2, these doses of DF-SDA did not cause any change in pulmonary artery pressures or left ventricular pressures.
TABLE 1______________________________________Peak Myocardial Videointensity of DF-SDACompared with PESDA in DogsContrast Agent PVI (Anterior Wall) PVI (Posterior Wall)______________________________________DF-SDA 2.8 � 0.6 unit 2.5 � 0.6 unitPESDA 2.1 � 0.4 unit 0.4 � 0.3 unit______________________________________
TABLE 2______________________________________Effect of DF-SDA on Pressures Before Injection After Injection______________________________________Mean Pulmonary 15.5 � 2.2 mmHg 15.6 � 2.9 mmHgArtery PressureLeft Ventricular 93.5 � 3.0 mmHg 93.3 � 5.4 mmHgSystolic PressureLeft Ventricular 0.3 � 0.7 mmHg 0.3 � 0.7 mmHgEnd-DiastolicPressure______________________________________
The stability of DF-SDA over a 48-hour time period was also determined in three separate samples. Measurements of mean microbubble size, percentage of microbubbles above 10 microns, and mean microbubble concentration were performed immediately after production and again at 36 hours after production. Neither microbubble size nor concentration changed over this time period. These data are summarized in Table 3 below.
TABLE 3______________________________________DF-SDA Stabi1ity Immediate 48 Hours______________________________________Mean size 4.7 � 2.5μ 4.8 � 2.7μMean concentration 1.60 � 109 1.68 � 109% Microbubbles >10 2.5% 3.6%microns______________________________________
Eight blood samples from four human volunteers were obtained to assess the effect of perfluorobutane gas on white and red blood cell counts. Each person had one sample exposed to 2 milliliters of perfluorobutane and one of their samples exposed to room air. As can be seen, there was no effect of perfluorobutane on white or red blood cell count, platelet count, or number of abnormal red blood cells seen on the peripheral blood smear (Table 4). (Results are the average of four volunteers' blood samples.)
TABLE 4______________________________________Effect of Perfluorobutane on Blood Before Perfluorobutane After Perfluorobutane______________________________________White blood count 6.7 � 103 6.6 � 103Red blood count 4.8 � 106 4.8 � 106Platelet count Adequate Adequate______________________________________
Therefore, perfluorobutane does not appear to adversely affect blood or sonicated albumin.
These preliminary data in animals and in-vitro studies with human blood demonstrate the safety of intravenous DF-SDA. It is critical to study the safety of DF-SDA in patients with coronary artery disease during resting and stress echocardiography. Perfluorobutane has already been used safely in humans during intraocular surgery and we anticipate from this information and our preliminary data that it will be safe in humans.
For humans, doses of from about as small as 0.0025 up to 0.08 ml/kg are given depending on the ultrasonic procedure used. The contrast agent is given by peripheral intravenous injection over 3-5 seconds followed by a 10 milliliter normal saline flush. (The dose range is patient-specific: large patients may require slightly higher doses to produce equivalent left ventricular contrast effects). Generally a patient would receive a 0.01 ml/kg of perfluoropropane sonicated dextrose albuminor 0.0015 ml/kg perfluorobutane sonicated dextrose albumin, as the initial injection. If this fails to produce myocardial opacification, the dose would then be doubled. The dose which produces myocardial opacification and improved detection of abnormal wall motion and left ventricular ejection fraction is used to determine myocardial blood flow by contrast echocardiography performed using the standard technique as described in Weyman, Arthur E., "Principles and Practice of Echocardiography", Lea & Febiger, Malvern, Pa. (1994, 2d Edition) and using the commercially available Hewlett Packard Sonos 1500 Phased Array Imaging System (Hewlett Packard, Andover, Mass.). Throughout the echocardiographic procedure, the patient's heart rate, blood pressure and oxygen saturation are monitored and recorded. The peak videointensity (corrected for baseline intensity) in the left ventricular cavity and myocardium for each injection is obtained.
Myocardial contrast produced from intravenous injection of two different molecular weight perfluorocarbon containing microbubbles in humans. The peak anterior myocardial videointensity (PMVI) and duration of acoustic shadowing (AS) produced by up to 0.02 ml/kg intravenous injection of perfluoropropane (molecular weight 188 grams per mole (g/m)) exposed sonicated dextrose albumin (C3SDA) were compared with 0.007 ml/kg intravenous injection of perfluorobutane exposed sonicated dextrose albumin (C4SDA) in 24 patients.
______________________________________PCMB N Dose PMVI AS (Sec) % 1 - 2 + MC______________________________________C3SDA 14 .02 � .08 2.1 � 1.5 50 � 15 5 (36%)C4SDA 10 .007 � 0.01* 1.9 � 1.8 31 � 21* 8 (80%)______________________________________ *p < 0.05 compared to C3SDA
Despite lowering the dose, intravenous injection of C4SDA produced significantly higher myocardial contrast, with significantly less AS. Thus intravenous perfluoropropane and perfluorobutane exposed sonicated dextrose albumin can be used safely in humans with significantly better myocardial contrast for perfluorobutane than for lower molecular weight perfluoropropane.
As can be seen from the foregoing, the invention accomplishes at least all of its objectives.
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Michael "Jake" McCleave Obituary
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: Michael "Jake" McCleave, 60, passed away July 25, 2012. He attended the Harrisburg City Schools and was a self-employed carpenter and roofer. He was preceded...
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SAVE B-377 Stratocruiser Airplane Model
One of your favorite miniature planes!
The Boeing 377 Stratocruiser was the civilian version of the C-97 Stratofreighter, which in turn was derived from the B-50 Superfortress. It first flew on July 8, 1947. Despite serious design flaws and a marginal service record, the Stratocruiser was considered one of the greatest post-war propeller airliners. In the 1960s, several Stratocruisers were modified by Aero Spacelines to make oversized transports and were dubbed as "Guppys".
The Boeing 377 was generally considered the greatest airliner in the air before the coming of the 707, and was the flagship of the Pan Am fleet. It has a seating capacity of up to 100 passengers on main deck and an additional 14 in lower deck lounge. The typical seating for 63 or 84 passengers, though it has a variety of interior configurations which could accommodate 55 to 112 passengers or if equipped as a sleeper, with 28 upper and lower berth units plus five seats. It incorporates 4 Pratt & Whitney R-4360-B6 Wasp Major 28-cylinder radial engines four-bladed propellers. It has a maximum speed of 375 mph and a range of 3,650 nm. The primary users and operators of the Boeing 377 are Pan Am and the BOAC.
Extremely complex and expensive, only 56 of the Boeing 377 were built. It continued in mainline service until 1960, when it had been made obsolete by the coming of the 707 and other first generation jetliners. In 1963, B-377s disappeared from service.
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Immigrant crossings into Arizona on the rise
NOGALES, Mexico The migrants walk for days through miles of mesquite scrub, running low on food and sometimes water, paying armed drug thug "guides" and dodging U.S. law enforcement officers along the way. And still they keep coming. The latest figures show that Arizona, which is about to put into effect the nation's toughest immigration law, also is the only border state where illegal crossings are on the rise.
While tightened security and daunting fences in Texas and California have made Arizona a busy crossing corridor for years, migrant smugglers now are finding new ways through the state's treacherous deserts.
Carmen Gonzalez, 27, recalled seven days and six nights of walking with her husband in the desert and being accosted by Mexican thugs with AK-47s, who demanded $100 bribes before abandoning them.
"It was so hard and so ugly," Gonzalez said at a shelter in this Mexican border town, where she, her husband and her brother were staying after being deported from Arizona. "I won't try again because we went through too much suffering in the desert."
New U.S. Border Patrol statistics show arrests on the Arizona border were up 6 percent - by about 10,000 - from October to April, even as apprehension of illegals dropped 9 percent overall. The agency uses arrests to gauge the flow of migrants; there are no precise figures on the number of illegal crossings.
Statistics from the Mexican side also show a rise in illegal crossings through Arizona.
Grupo Beta, a Mexican government-sponsored group that aids migrants, helped 5,279 people from January to April in the area across the border from Douglas, Ariz., compared to 3,767 in the same period last year, said agent Carlos Oasaya.
That's the same area where Arizona rancher Robert Krentz was fatally shot in March as he surveyed his property in an all-terrain vehicle. Authorities suspect an illegal immigrant who was headed back to Mexico and worked as a scout for drug smugglers.
The killing helped fuel the emotion around the Arizona law, which will empower police to question and arrest anyone they suspect is in the country illegally. It takes effect in July.
Immigration is likely to be at the top of the agenda Wednesday when Mexican President Felipe Calderon visits Washington and attends a state dinner at the White House. Calderon has condemned Arizona's law; President Barack Obama has called it "misguided" and promised to begin tackling an immigration overhaul.
Supporters of the Arizona law said Tuesday that the growth in arrests at the border didn't spur its passing.
Instead, it was a series of factors, including the discovery of a growing numbers of immigrant safe houses and a rise in crime by illegal immigrants who have injured and killed police officers, said state Rep. John Kavanagh.
In the 1990s, increased enforcement and corrugated metal and chain-link fences dramatically cut illegal border crossings in California and Texas.
Overall, illegal immigration through those two states, New Mexico and Arizona has declined from nearly 1.2 million in 2005 to 541,000 last year, according to the Border Patrol. In Arizona, illegal crossings fell from 578,000 in 2005 to nearly 250,000 last year - before the recent rise.


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Tasty healthy fish fillet with steamed vegetables, isolated on white background, border with text space
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Show all reviews
Madness by Chopard
When it's wrong on you, it is dreadfully wrong, but when it is right, it is unusual and sublime! In the eighties I wore Parfum Rare by Jacomo. Madness comes close, but with a slightly sweet softness around the edges where Parfum Rare had a delicate aridity. I will wear it this winter for sure. It reminds me of how my wool coat smelled after wearing Parfum Rare on a night out at my favourite Italian restaurant nearly twenty years ago.
15th November, 2005


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
31 year old man | Live Oak, TX, USA | Seeking women 21-30 within 100 miles of San Antonio, TX
Looking for a Texas Angel...
Well I am a down to earth guy that enjoys the simple things in life. Sports and Outdoors are a big part of what I do when I am not at the office. I enjoy hunting, fishing, and playing golf. I love watching Aggie football, force myself to not get to upset while watching Cowboy football, and enjoy watching baseball games (fan of both the Rangers and Astros). I have great friends and family and would do anything for them. Im looking for a girl that shares the same interests as me but they are their own person. I am interested in someone that can expose me to new interests and new experiences, and hopefully, I will do the same for her. She has to be smart, sweet, and christian. Of course, beauty is in the eye of the beholder, and I typically like a girl that is beautiful no matter if she is dressed up, or lounging around in jeans, a tshirt, with no makeup and her hair up in a pony tail. She also must be a fun person to be around, have a good sense of humor and someone that challenges me to be a better person. I am looking for someone that can be my partner for what will surely be a great adventure.
Camping , Coffee and conversation , Cooking , Dining out , Fishing/Hunting , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing cards , Playing sports , Political interests , Religion/Spiritual , Travel/Sightseeing , Video games , Watching sports
Auto racing / Motorcross, Baseball, Basketball, Billiards / Pool, Bowling, Dancing, Football, Golf, Running, Swimming, Walking / Hiking, Weights / Machines
I exercise 1-2 times per week.
I have Cats, Dogs
I like Fish, Gerbils / Guinea Pigs / Etc., Horses
I have a Lab named Belle and a basset hound named Molly. I have one cat name Oreo.
Anywhere in the hill country, the coast, the river, or Las Vegas.
The University of Texas at San Antonio, San Antonio, TX
My favorite places to eat are quite and filled with good conversation. My favorite book is count of monte cristo, and I have a wide variety of favorite movies. I love country music with george strait being my favorite,
I like to hunt, fish, watch/play sports, and explore new things with my friends.I enjoy a relaxing evening at a corner bar throwing some darts or shooting pool. Nights out on the town, traveling, concerts, and movies are also fun.
My last read was Killing Kennedy, which is an amazing novel that I would recommend to anyone. Looking for my next book at the moment.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'10" (177cms)
|4'11" (149cms) to 5'10" (177cms)
|Body type:
|About average
|Slender, About average, Curvy, Athletic and toned
|Blue, Brown, Grey, Green, Hazel
|Light brown
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way, Occasionally, Yes, but trying to quit
|Social Drinker
|Never, Social Drinker
|Financial / Accounting / Real Estate
|No preference
I work for a large bank in San Antonio. I am hoping to eventually be very successful in the finance area of a bank
|I'll tell you later
|No preference
|Never Married
|Never Married
|Have kids:
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|Definitely, Someday, Not sure
|Latino / Hispanic, White / Caucasian
|Latino / Hispanic, White / Caucasian
I was born and raised in san antonio, my mom is hispanic and my dad is white.
|Christian / Other
|Christian / Catholic, Christian / LDS, Christian / Protestant, Christian / Other
I was born and raised in the catholic church, but lately have found myself wanting to see what other religions have to offer.
|Bachelors degree
|Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral
I graduated from UTSA with my Finance degree, and am currently working on my master's degree. I am also looking to start a certification program too.


text:
Parents Daily News Roundup
Friday, August 26th, 2011
Grandparents Play a Bigger Role in Child-Rearing
Less frail and more involved, today's grandparents are shunning retirement homes and stepping in more than ever to raise grandchildren while young adults struggle in the poor economy.
When Schools Depend on Handouts
Earlier this month, Mayor Michael R. Bloomberg announced that he and five other wealthy individuals had raised $1.5 million to reinstate the January Regents exams, which New York State had canceled because of budget cuts. Although praiseworthy as a matter of personal philanthropy, the donation by the mayor and the others, whose names were not disclosed, is highly distressing as a matter of public policy.
Chocolate Milk Gets a Makeover
Parents who are concerned about the amount of sugar their children are chugging in school cafeterias may be encouraged by an announcement from the milk industry. Starting in September, chocolate milk will have fewer calories and less sugar.
Five Healthiest Vacuum Cleaners for the Home
The right vacuum is key for good health. "Dust can trigger allergies and asthma," says James Sublett, MD, a spokesman for the American College of Allergy, Asthma, and Immunology.
Tags: allergies, asthma, chocolate milk, education, grandparents, schools, vacuum | Categories: GoodyBlog, News


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Maximize the power of Crystal Reports and import and analyze data from a variety of places, including Excel, Access, HTML/XML files, and more.
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I'm due 4/5 and my first day of maternity leave is 4/1. I figure if anything I'll have a week or so to get a last little bit of "me time" before the baby comes.
I am working until the bitter end so that I can take my full 12 weeks with baby. My body will hate me ( I work 12s and 8s as a nurse) but I can neither afford to take more then the 12 weeks nor risk losing my job. Though my employer did allow one nurse about 4 years ago to take 6 months off ( most unpaid). We were us a good place though at that time. Good luck! I hope you can find a way to have it all work out!
Leah : 1st time mommy
*wife to the most amazing man <3 9.18.10
expecting our femara baby boy 4.9.13 !!!
Isla Azure 8/11/10
Angel Baby Boy 2/14/12 12 weeks pmp
Tristan Sean 4/11/13
In California, we can take off up to a month before the due date on state disability. This takes up precious FMLA time, however, CFRA (California Family Rights Act) also gives 12 weeks of job protected status, but it only starts after the baby is born. So with a due date of 4/4, I could go out 3/8 and still get 12 weeks after baby comes. Even if the baby is late a week or two.
For once, California does SOMETHING right. I don't get to say that very often.
(And I was going to go out 3/8 but we're trying to buy a house and it was delayed due to a short sale, so looks like I will have to stay employed until 3/22 to qualify for the loan. Irritating, but still gives me 2 weeks. Provided baby doesn't decide to come early!)
Ayme (27) & Ben (31) Married 7/19/08 / Ian born 3/19/13 after 2 years TTC and 37 weeks 5 days of pregnancy
Baby 3 EDD 10/14/15
I agree that it all depends on your job and how you feel! I was going to go on mat leave in Jan as I had preterm contractions, but then felt great again and have had no problems since so continued to work (of course being careful and monitiring how I felt)...however my job is also quite physically draining and stressful so will stop completely March 01 to give my little K a good 5 weeks of complete rest...but then I will have to deal with the boredom (watch out for MANY more posts from me then) haha


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Microfluidics Is On a Roll and...
The New Frontline of Infectious Disease...
GBSI Is Taking Action to Reduce...
The Best Conceptual Framework for Improving...
PolyMedix received the second phase of a grant from the National Institutes of Health (NIH). The grant provides funding of up to $1 million per year for three years to support the discovery of a lead anti-malarial product candidate and will continue to fund collaborative work with Doron Greenbaum, Ph.D., assistant professor of pharmacology at the University of Pennsylvania, to support the development of defensin-mimetic antimicrobial compounds for the treatment of malaria.
This phase was awarded after the team of PolyMedix and the Greenbaum laboratory successfully completed a first phase which included generating proof-of-concept data for the defensin-mimetics through in vitro and in vivo efficacy testing.
PolyMedix's defensin-mimetics target the digestive vacuole of the parasite that causes malaria, Plasmodium falciparum, via a mechanism distinct from other anti-malarial agents, essentially starving the parasite of food. The data from in vitro and in vivo testing showed PolyMedix's defensin-mimetics killed the Plasmodium falciparum in infected human red blood cells without damaging uninfected red blood cells. In vivo activity was also seen with a potential lead compound on malaria parasite clearance and animal survival in a mouse malaria model. These data were presented by PolyMedix's collaborator on the grant, Dr. Greenbaum earlier this year.
"Resistance has developed to many current therapies for malaria," Dr. Greenbaum commented, "Targeting parasite membranes rather than proteins using PolyMedix's defensin-mimetics represents a highly innovative and novel approach for treating parasitic diseases. I look forward to collaborating with PolyMedix on this grant."
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text:
Originally written on Ranger Nation | Last updated 10/15/11
PITTSBURGH - OCTOBER 2: Craig Adams #27 of the Pittsburgh Penguins defends against Marian Gaborik #10 of the New York Rangers on October 2, 2009 at Mellon Arena in Pittsburgh, Pennsylvania. (Photo by Jamie Sabau/Getty Images)
… yes, this was a BEAUTIFUL goal but the best part about it was the amazingly accurate pass from Brad Richards. Richards is worth his weight in gold and if both he and Gaborik stay healthy this will be a fun line to watch all season long.
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A hand-crafted webirc server
Kiwi IRC is a fully featured IRC client that can be extended to suit almost any needs. Using the web application is extremly simple even without any IRC knowledge as all the common needs are built directly into the UI.
For more information see http://kiwiirc.com or an example of the application can be found at http://kiwiirc.com/client/
Download the Kiwi source or clone the git repository:
$ git clone email@example.com:prawnsalad/KiwiIRC.git && cd KiwiIRC
Install the dependancies and make sure the client code is built:
$ npm install
$ node client/assets/dev/build.js
Copy and edit the configuration file as needed:
$ cp config.example.js config.js
$ nano config.js
From the source folder:
$ ./kiwi start
You can also run kiwi in the foreground to see any output by using the
-f flag. Eg:
$ ./kiwi -f
Open your new Kiwi instance in your browser. By default: http://localhost:7778/
Report bugs using the issue tracker on github: https://github.com/prawnsalad/KiwiIRC/issues
GNU Affero http://www.gnu.org/licenses/agpl.html
The KiwiIRC logo credited to Michael Drahony (www.drahony.com)


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Hello. If you're reading this post it means something, even if it's a very small something is going right in this house. Something being, both kids are napping at the same time. Because that time my friends and ONLY that time is when we can talk. Oh, and only after I cook 40 meals from scratch in my kitchen.
Wait. What was that last part?
Me? Cooking a bunch of shit?
Yes. Oh yes.
My diet has morphed from restrictive for breastfeeding, to Paleo, to Whole30 and now the Candida Diet (removing yeast). All to help my little bugger Ruby feel better. She now has full body eczema, mucus face, man farts and sparse poops. We went to the naturopath yesterday and were told that she has too much yeast and is reacting. That means, no fruit, no honey, and definitely no gummy penguins. Listen, I know it's my choice to do this. But manalive cut me a break with this food shit. Also, who am I? Martini MODG barely recognizes this frizz ball makeupless train wreck.
If I squint real hard and tilt my head and suck in my gut, I can kiiiind of remember the cool weird girl that started this blog. I remember posting pictures of a shaker and martini glass and being all, "my evening". And that would be the whole post. Ok quality lacked around here, but my life was miles different than what it is now. A good newlywed friend of mine just informed me that my last "drunk" category post was 2 full years ago. She asked me to rectify this. Another commenter asked that I start posting more of what my "adult" life is like these days. Both had good intentions, but friends without kids, hear me now: THERE IS NO ADULT LIFE. You think I'm exaggerating. You know, because that's what I do around here. I'm not.
Let me break it down for you:
Wake up either from a grunting baby next to me or a toddler jumping on top of me saying "more special movie" "more special movie" (this is what he calls cartoons. TV has become the 5th family member since Ruby arrived)
Hold one kid while getting another dressed, reverse.
Prop small one somewhere and occupy toddler with a brush and my bra drawer while I somehow get dressed
Sometimes I look in the mirror
Play trains, feed baby, play trains, feed baby, play trains, feed baby, change diaper, play trains, feed baby, play trains, feed baby, change diaper.
TRAINS. (these guys are my train relief)
Cook lunch while holding baby. Try not to drop her on anything hot. Drag toddler around on my leg as he screams MORE CHEESE. (?)
Prop baby, nap G. Nap involves extreme routines involving specific clothes, diapers, sounds, stars, lights, books, blankets, dolls, lighting concept, etc. It takes a full half hour.
Baby has HAD IT.
Feed her, nap her.
RUN downstairs. Cook everything in the kitchen for dinner, for breakfasts, etc. for B and I containing only safe ingredients for our stupid diets. Worry about G's food later.
30 minutes. Baby is awake. Stare at her in the video monitor like a mental patient. She goes back to sleep. Whew…
MOMMYCOMEINMOMMYCOMEIN G is up. Shit. Sa;lskdjf;laksdjf;lkj
Tell him to be quiet because he will wake up Ruby.
Cook more.
This cycle repeats 3 times.
Everyone is up. I am out of breath.
play trains, feed baby, play trains, feed baby, play BLOCKS, feed baby (crazy I know).
Get dinner on the table
Baby wants me, not dad. Duh.
G wants me to PLAY GD TRAINS AGAIN. Dad isn't cutting it.
SHOVE food into my mouth so I can pick up the baby.
Bath time.
Dad does bath. I get Ruby. Switch.
G to bed. Wants mommy to read to him.
Ruby screams, wants mom. Duh, who doesn't. Mom is cool. But please hang out with DAD.
*****SUPER SPECIAL ADULT MOM TIME***** here it comes everyone, my special time———————->
I am alone and it's my very own time.
I do not get to dry my hair though. I have to run down and get Ruby because she's screaming.
Feed Ruby and watch the Bachelor in 30 minute increments every night. I'm on episode 2.
9:30pm Ruby is tired, sleeps next to me and will only stay asleep next to me. So I sleep. She moves to her crib around midnight.
See how there wasn't like, wine time in there? There wasn't any chocolate and internet shopping time? There wasn't any, read my Lucky mag time and take toilet pictures time? And no, there wasn't even blog time.
Listen friends, I'm not complaining. I have a really cool little family and it's my job to be the momma. And I know this is all a phase as I've said. But it's literally every minute of every day. There is no adult fun time. I hate to break it to everyone who doesn't have little bundles of poop and pee yet. But let me tell you this, you will be SO good at playing trains. You will play the shit out of those trains.
So stay with me folks. You'll see more of me as time goes on. And the more you see of me, the better you know we're doing. Because somehow I'm alone, at my computer and I'm breathing (and maybe drinking wine. Praise Britney, please let me be drinking some wine)
I will have non mom skinny jean post #2 for you soon. You know, when I get time.


text:
Sent from my GT-I9100 using XDA Premium 4 mobile app
Lordy. Are you kidding me?
Of course it is possible...AAMOF, for most KitKat ROMs on the Sprint SPH-L900 enabling ART WILL render your ROM unbootable and the only "fix" (that I know of) is a Nandroid restore. AFAIK the only ROM for L900 with working ART that I know of is OmniROM, although I will admit I haven't tried straight CyanogenMod in forever. "Working" meaning enabling ART doesn't break your ROM. Because what will happen otherwise is after enabling ART and immediately rebooting, your ROM install will permanently bootloop, and the only way of getting it back is Nandroid recovery.
Don't believe me? Download or read the XDA forums for Dirty Unicorns 5.0 or SlimKat (no offense intended at Maz or sleshy who do mad work on those ROMs and who are more than aware of this issue). Then you'll see exactly what I'm talking about and that it is you who are "spreading false information". Further even within the same ROM, enabling ART can break the ROM for some devices but not others. If you read or follow Google+ dev communities for OmniROM and others you'd know this.
"False information" indeed.
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Originally written on Fox Sports | Last updated 12/2/12
Aaryn Ellenberg scored 18 points and Whitney Hand grabbed 13 rebounds to lead No. 12 Oklahoma over Marist 68-55 Sunday, extending the Sooners winning streak to six games. Ellenberg had three steals, scoring of us two. Hand also had 12 points for her first double-double of the season, and five assists. Morgan Hook scored 16 points. Oklahoma led at halftime 34-30, took off in the second half, outscoring Marist 34-25. The Sooners (7-1) finished the game on a 17-5 run. Emma O'Connor scored 18 points and Elizabeth Beynnon 13 for the Red Foxes. Leanne Ockenden had 10 points and led Marist (4-4) in rebounds with six.
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