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Posts Tagged 'Robert Lowell'
Is There a Vespa?: An Interview with Michael Hofmann
December 4, 2014 | by Jack Livings
Michael Hofmann's first collection of poems, Nights in the Iron Hotel, came in 1984, and in the ensuing thirty years he has translated more than sixty novels from the German and published five more poetry collections, along the way collecting numerous prizes for his work. He is the editor of an anthology, Twentieth-Century German Poetry, and in 2002 published a collection of critical essays, Behind the Lines. (This is far from a comprehensive accounting.) The thirty essays in his new collection, Where Have You Been?, visit a range of poets, novelists, and artists of the last hundred years, including Elizabeth Bishop, Robert Lowell, Thomas Bernhard, Kurt Schwitters, and Frederick Seidel.
Hofmann's essays are intense inquiries: he tunnels deeply, engages profoundly, and whether or not he likes what he's read or seen, his essays ennoble the work under review. There's a sense of humor, even joy, electrifying the enterprise. Of course, his criticism can pulverize, too—Günter Grass and Stefan Zweig are destroyed in Where Have You Been?—but most of Hofmann's selections tend toward the form of one reader grabbing another's sleeve and shouting, Come on now, this way! You've got to see this!
Though Hofmann doesn't keep a computer at home—"usual Luddite setup," he said at one point—this interview was conducted over e-mail. On a couple of occasions, he wrote from a stand-up terminal in a municipal library.
You've written that contemporary American poetry is "a civil war, a banal derby between two awful teams." In Britain, it's "a variety show." These are grim assessments.
Discouraging, isn't it? It's just a fact that there are never very many poets around at any given time. I think poetry is always one or two poets away from extinction anyway. If it's any comfort, it's not a living tradition—it doesn't depend on being passed from hand to hand. It could easily go underground for a couple of decades, or a couple of centuries, and then return. People disappear, or never really existed at all, and then come back—Propertius, Hölderlin, Dickinson, Büchner, Smart. Poetry is much more about remaking or realigning the past than it is about charting the contemporary scene. It's a long game. Read More »
Talking Tate: A Fake Oral History
November 19, 2014 | by Dan Piepenbring
There's no Writers at Work interview with Allen Tate—who was born today in 1899—but his name seems to pop up in nearly everyone else's. By my count, he has cameos in nineteen of our interviews; he shuffles onstage to offer an apercu or to help someone or to drink or to be carried down a flight of stairs. And then he leaves.
Tate ran in many circles, in part because his teaching allowed him to move around so much. At one point or another he crossed paths with an astonishing number of his fellow writers: Robert Penn Warren and Robert Lowell, most prominently, but also Randall Jarrell, John Gould Fletcher, John Crowe Ransom, John Berryman, and Andrew Lytle. His walk-ons in The Paris Review interviews testify to his influence not just as a poet but as a friend. If you read these mentions of him in succession, as a kind of patchwork oral history, you get a strangely gratifying secondhand sense of the man, as if someone had painted his portrait based only on a description. Let's give it a try— Read More »
Robert Lowell's "Epilogue"
September 10, 2014 | by Sadie Stein
If you write, and you are not a journalist, and you don't write fiction, people want to know why. These are hard questions to answer. Sometimes one admires fiction too much to attempt it. Sometimes one lacks the gift for invention. No one gets at the particular challenges of the fact/fiction relationship—or indeed, the exigencies of the creative process—better than Robert Lowell. Especially the poem "Epilogue." Lowell's work may be a monument to unapologetic narcissism (an artistically necessary narcissism, defenders could say, or at the very least indivisible from either his genius or his illness) but here, it seems to me, there is only enough self to propel the project at hand. If you listen to him read it, he sounds downright humbled by the weight of creative challenge. As a friend pointed out, it is interesting that his stepdaughter should title her memoir—so full of his destructive recklessness—Why Not Say What Happened? After all, this poem is more introspective, less destructive, than so many others. That is for her to say, of course. In a way, it's the best memoir title in the world. Read More »
For the 1 Train Dead
August 28, 2014 | by Sadie Stein
New Yorkers like to affect jadedness in the face of celebrity; we yawn, we stare fixedly in the other direction, we scorn star-struck tourists And yet today, I had a celeb sighting so exciting I reacted like a middle-schooler at a taping of Total Request Live.
I had just entered a pleasantly empty subway car, only to discover the cause of its emptiness—a broken AC—too late. I was cursing my luck and considering an illegal dash between cars when I saw him. There, across the aisle, and under a Poetry in Motion poster, was Robert Lowell. To the life: the patrician features, the distinctive nose, eyes that had known suffering and pain as well as realms of genius invisible to the normal run of mortals. He was not a man in the first blush of youth; this was "Day by Day"–era Lowell. He was wearing a rumpled linen jacket and tie. Of course he was.
All thoughts of changing cars having fled, I took a seat directly opposite and stared. There was no question about it: this was Robert Lowell. Maybe a ghost. At the very least a relative. He could certainly have made a good living as a Lowell impersonator, traveling the world and reciting confessional poetry with a Brahman inflection. Well, a living, anyway.
I waited for my chance. I didn't want to strike too soon, but on the other hand I couldn't live without knowing. Best-case scenario, he'd break into "Life Studies."
I timed it carefully. When we were one stop away from my point of departure, I planted myself in front of him. "Excuse me, sir?" I said, my voice quavering. He looked up. His eyes were very, very sad. "Has anyone ever told you how much you look like Robert Lowell?"
For a horrible moment, the lack of comprehension on his face was such that I thought he might not speak English. But then he said, "Robert who?"
There were two French tourists watching the proceedings with interest. Maybe they didn't realize that other cars were air-conditioned.
"Robert Lowell, the poet," I said. "It's a compliment. He was an excellent poet! And handsome! I mean, he had his problems"—I said this in case he should look up his biography and think I had been less than forthcoming—"but who doesn't?"
"Oh," he said. "Thanks, I guess."
I turned my back and stared at the doors for what felt like an eternity. It must have been a hundred degrees in there. Frankly, I thought, if that guy wasn't Robert Lowell, and either mentally ill or supernatural, it was really weird that he was sitting in this sweltering car. Frankly, it was irrational.
Lonely Thinking: Hannah Arendt on Film
May 30, 2013 | by Roger Berkowitz
In 1963, The New Yorker published five articles on the trial of Adolf Eichmann, the Nazi chief of Bureau IV-B-4, a Gestapo division in charge of "Jewish Affairs." Written by political thinker and Jewish activist Hannah Arendt, the articles and ensuing book, Eichmann in Jerusalem, unleashed what Irving Howe called a "civil war" among New York intellectuals. While some reviews cursed Arendt as a self-hating Jew and Nazi lover, the Jewish Daily Forward accusing her of "polemical vulgarity," Robert Lowell termed her portrayal of Eichmann a "masterpiece," and Bruno Bettelheim said it was the best protection against "dehumanizing totalitarianism." Across the city, Arendt's friends chose sides. When Dissent sponsored a meeting at the Hotel Diplomat, a crowd gathered to shout down Alfred Kazin and Raul Hilberg—then the world's preeminent Holocaust scholar—for defending Arendt, while in The Partisan Review Lionel Abel opined that Eichmann "comes off so much better in [Arendt's] book than do his victims."
In the years since that fiery time, Eichmann in Jerusalem has remained something to condemn or defend rather than a book to be read and understood. I therefore had some fears when I heard that German director Margarethe von Trotta was making a film about Arendt's coverage of the trial. But Hannah Arendt accomplishes something rare in any biopic and unheard of in a half century of critical hyperbole over all things Arendt: it actually brings Arendt's work back into believable—and accessible—focus.
The movie opens with two wordless scenes. The first depicts the Mossad's abduction of Eichmann. The second follows a silent Hannah Arendt as she lights, and then smokes, a cigarette. Around her, all is darkness, and for a full two minutes, we watch her smoke. Played with passionate intensity by Barbara Sukowa (who won a Lola, the German Oscar), Arendt ambles. She lies down. She inhales. But above all, we see the cigarette's ash flare brilliantly in the dark. Hannah Arendt, we are to understand, is thinking.
Although Arendt's work follows numerous byways, one theme is clear: in modern bureaucratic societies, human evil originates from a failure not of goodness but of thinking. Read More »
House of Poesy: At the Grolier Poetry Book Shop
February 26, 2013 | by Rhoda Feng
The Grolier Poetry Book Shop in Cambridge, Massachusetts, is both a misnomer and an anomaly. It has long dedicated itself to the task of promoting the reading and writing of poetry and has, for eighty-five years, served as a niche for poets the world over. While its reputation has bloomed over the years, thanks largely to word-of-mouth praise, it has never fared well financially, partly due to competition from larger stores and the Internet, partly because poetry has never been popular with the masses, and partly because its founder seems to have done everything in his power to ensure that his store not be turned into a business.
Located on Plympton Street in Harvard Square, the Grolier occupies just 404 square feet of space and is dwarfed by the neighboring Harvard Book Store. A white square sign with meticulous black lettering juts out near the top of the store entrance. The font size decreases from top to bottom, much like on an eye exam chart, and one can just make out, at the very top, a finely done illustration of three cats (or is it the same cat?) dozing, grooming, and turning their backs on the viewer.
Upon ascending a small flight of steps, one is greeted by the sight of an abundance of colorful spines—approximately fifteen thousand—neatly arranged against nearly every flat surface of the shop. These volumes are neatly balkanized into several categories, including anthologies, used, African-American, early English, Irish, Russian, Chinese, Iranian, Indian, Latin, classical Greek, Japanese, Korean, East European, Spanish, and Catalan.
Above the towering shelves are approximately seventy black and white photos (many courtesy of the photographer Elsa Dorfman) of poets and other members of the literati for whom the Grolier has served as a meeting place for well over half a century. Among the Grolier's most illustrious visitors, most of whom are smiling or gazing sagely and serenely ahead in the photos, are T. S. Eliot, Robert Lowell, Elizabeth Bishop, e. e. cummings, Marianne Moore, James Tate, Donald Hall, and Helen Vendler.
Off to one side at the front of the store sits a lean shelf of chapbooks and a donation jar; a small note says that the chapbooks have been generously donated by the author and that monetary contributions to the shop would be greatly appreciated. Directly across this bookcase is the cash register, propped up on a desk and flanked by sundry items, including bookmarks, promotional literature, pamphlets, business cards, and commemorative pens. On the wall right adjacent to the register hangs a certificate from Boston Magazine honoring the Grolier as the best poetry store of 1994. Read More »


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Will your containerized data center survive the elements?
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Environmental resistance is another issue that is largely overlooked when considering a containerized data center. There is no single answer, but containers are basically steel boxes that are full of complex and expensive equipment. The problem is that steel rusts; it doesn't need water, only oxygen. In addition, steel can undergo significant expansion and contraction as outside temperatures change. Even galvanized steel that is treated to withstand the elements can form leaks that might eventually allow water penetration and unwanted pests that will cause problems for systems, wiring and IT personnel.
In many cases, environmental resistance is ignored because the container is leased or purchased with the expectation of a limited lifespan. Most servers are replaced every three to five years, and containers frequently fall into that same cycle. For example, you would not replace the servers within a container; you would replace the entire container -- servers and all. So a well-designed container can typically fend off the elements for a normal lifecycle without significant difficulty.
However, many organizations that rely on containers as a permanent modular data center strategy will usually house their container fleet under some sort of warehouse-like enclosure. This extra measure of protection improves physical security for the containers and computing equipment inside, mitigates daily or seasonal temperature changes and reduces environmental exposures that can cause rusting and premature failures.
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A recent study in 43 countries concluded that children in schools where tobacco-free policies were firmly enforced were much less likely to smoke. However, anti-smoking lessons in classrooms had little impact on smoking rates. Not a surprise. Educational campaigns seeking to change people's behaviour regarding consumption are notoriously unsuccessful, by themselves, whether in terms of tobacco, alcohol, gambling, drugs, or non-nutritious eating. The claims of education can sometimes be pretty grand.
There are many factors we can't control that affect our cancer risk, like growing older, our genetic profile and having a family history of the disease. But the good news is that there is a lot we can control. It's as simple as making healthy choices every day and having policies in place that protect our health. Here are the top 10 ways to lower your risk of cancer.
While the house party that was recently broken up by police in Brampton had some expensive -- and terrifying -- lessons for the families involved, they're teachable moments for the rest of us. So, here's a checklist of what to ask your teen before they hit the party circuit this weekend or this summer.
When it comes to the climb of pop stardom, Miley Cyrus has proven she can't be tamed. Earlier this month, the singer posted a photo showing a new tattoo in a rather unlikely place: her lower lip. Unlike the other maneuvers, which may have social consequences, this one could lead to medical problems.
When was the last time you saw a pregnant woman sipping a beer? If you are North American, the answer might be never. You might also be surprised to learn that in much of Europe, it's actually not unusual at all. Now, more and more women I know are choosing not to totally abstain from alcohol during their pregnancies. And everyone in their lives are completely losing their minds about it.
This is an excerpt from Anne Dowsett Johnston new book Drink: The Intimate Relationship Between Women and Alcohol. Thanks to the creative, targeted marketing of the alcohol industry, alcohol has a prominent, stylish presence in the lives of women today. However with this newfound popularity over the last decade comes the disturbing rise of binge drinking, DUIs, "drunkorexia" and alcoholism.
In 1920, marijuana was legal in British Columbia, but alcohol was not. What if that was still the law today? Can we imagine a parallel world where alcohol prohibition never ended, and marijuana prohibition never began? In that world, provincial politicians promote B.C.'s vibrant marijuana industry, posing with brand-name joints of B.C. bud, while also calling for longer sentences against brew-ops and wine dealers, to protect youth against the dangers of liquor.
The looming LCBO strike threat has suddenly gotten all sorts of Ontarians anxious about a potentially dry next few days (or weeks). LCBO workers, who are represented by the Ontario Public Service Employees Union (OPSEU), voted 95 per cent in favour of striking, and the deadline is approaching. Yet a strike is in no one's best interests. Now, this entire scenario would change if the availability of alcohol were to be completely diminished. This inconvenience may cause citizens to want an alternative to the LCBO in the event it is rendered incapable by a strike.
You've all heard "you are what you eat" before, right? Well we now know that that is true on a more fundamental level than you ever could have imagined. So, is it possible that the foods we eat can be changing this chemical and physical make-up to actually create feelings of stress and anxiety? Absolutely! Check out the top five foods that can affect your brain chemistry and cause stress and anxiety.
Glamour once ran an article called "30 Things Every Woman Should Have and Know by the Time She's 30." Neither section really captures the unbelievable amount of work women in their twenties do as they transform themselves from teenagers to adults. It's a lot. It takes more than a trip to Home Depot or Victoria's Secret.


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by Alex Leichenger Posted on March 19, 2014
James Inhofe, the former chairman of the Environmental and Public Works committee, thinks he has a shot to re-attain his old position.
by Rebecca Leber Posted on January 6, 2014
Cold weather tends to bring the climate change deniers out -- in the Senate, that would be Senator James Inhofe (R-OK).
by Joanna M. Foster Posted on November 15, 2013
While Google and Facebook make new investments in renewable energy, their ties to climate change denying politicians and organizations continues to come under question.
by Josh Israel Posted on August 23, 2013
Sen. Jim Inhofe (R-OK) blasted a proposed Pentagon policy aimed at giving same-sex couples the time to travel to states where they can legally marry --claiming that doing so would amount to "special uncharged leave benefits" for same-sex partners.
by Ryan Koronowski Posted on August 1, 2013
The Koch brothers and the petroleum companies they own are so scared of a carbon tax, they hired a former Cantor aide to lobby to pass a nonbinding resolution.
"There are times where companies like Google must display moral leadership and carefully evaluate their political bedfellows."
by Brad Johnson - Guest Contributor Posted on July 24, 2013
by Tiffany Germain - Guest Contributor Posted on July 21, 2013
by Kirsten Gibson - Guest Contributor Posted on July 18, 2013
by Brad Johnson - Guest Contributor Posted on July 11, 2013


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Belichick, Kraft were interviewed in Hernandez probe
Investigators probing a murder allegedly committed by former New England Patriots star Aaron Hernandez interviewed Patriots coach Bill Belichick and team owner Robert Kraft last summer.
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At 8:30 am ET, the National Journal's Hotline and Westhill Partners hosted a breakfast briefing on this month's poll, on immigration, and a panel discussion with Rep. Tom Tancredo (R-CO), the Hotline's Chuck Todd, Ed Reilly of Westhill Partners, and GOP strategist Ed Rollins.
At 2:30 pm ET, the Senate Judiciary Committee considers the nominations of Terrence Boyle to be U.S. Circuit Judge for the 4th Circuit Court of Appeals; James Dever to be U.S. District Judge for the Eastern District of North Carolina; and Robert Conrad to be U.S. District Judge for the Western District of North Carolina. The nominees testify.
At 11:30 am ET, Sens. John McCain (R-AZ) and Joe Lieberman (D-CT), and Reps. Frank Wolf (R-VA) and Tom Lantos (D-CA) hold a news conference to announce the Advance Democratic Values, Address Nondemocratic Countries and Enhance Democracy Act of 2005.
At 12:30 pm ET, Energy Secretary Sam Bodman and Interior Secretary Gale Norton join Sens. Pete Domenici (R-NM), Lisa Murkowski (R-AK), Robert Bennett (R-UT), James Bunning (R-KY) and John Thune (R-SD) hold a news conference to talk about the upcoming CODEL to ANWR.
At 10:00 am ET, Health and Human Services Secretary Mike Leavitt, Energy Secretary Sam Bodman, and Commerce Secretary Carlos Gutierrez are all on the Hill testifying in hearings on their agencies' FY2006 budget appropriations.
At 2:00 pm ET, the House Armed Services Committee looks at the FY2006 budget request and its ability to meet military readiness needs. General Richard Cody, vice chief of staff for the Army; Admiral John Nathman, vice chief of Naval Operations; General Michael Moseley, vice chief of staff for the Air Force; and General William Nyland, assistant commandant for the Marine Corps, testify.
At 2:30 pm ET, the Senate Special Committee on Aging holds a hearing to look at the effect of the Medicare Modernization Act; Medicare administrator Mark McClellan testifies.
Happy birthday to pressgaggle.com.
Social Security: the politics:
The Des Moines Register's Jane Norman leads breathlessly:
"Senate Finance Committee Chairman Charles Grassley of Iowa said Wednesday that Congress should focus on the solvency of Social Security rather than the president's plan to create personal investment accounts for younger workers."
"Grassley, a Republican and the head of the committee that would handle any Social Security overhaul in the Senate, said he still intends to try to get a bill approved this year. 'But maybe we ought to focus on solvency, and bring people to the table just over what do you do for solvency for the next 75 years,' Grassley said in a conference call with Iowa reporters."
Democrats are, as you can imagine, quite pleased about all this.
The Chicago Sun-Times' Bob Novak leads breathlessly:
"George W. Bush, who is not prone to confessing mistakes, has confided to close associates that he committed a whopper on Social Security. He admitted error in pushing for new personal accounts while not stressing the repair of the safety net for seniors. As a result, Republicans returned to Washington this week from the congressional recess deeply shaken by what they encountered back home."


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A $322 million jury award in an asbestos case should be thrown out, and the judge removed because he didn't disclose that his father had filed asbestos claims, according to a motion from one of companies sued.
But an attorney for Thomas "Tony" Brown Jr. of Brookhaven said Circuit Judge Eddie Bowen was fair to both sides.
The award against Chevron Phillips Chemical Co. and Union Carbide Corp. in Smith County Circuit Court was the largest single verdict in a U.S. asbestos case, Brown's attorneys said following the verdict earlier this month. ...


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Kelly's RoadhouseRead MoreFor a mouthwatering meal you're sure to love, Kelly's Roadhouse in Morgan is the place to be. If you're avoiding fat or gluten, you can still eat great at Kelly's Roadhouse, which offers a number of low-fat and gluten-free choices. Groups of all sizes can easily be seated at Kelly's Roadhouse. No need to dress up for a trip to Kelly's Roadhouse — the casual restaurant encourages laid-back attire. Drive to lunch or dinner at Kelly's Roadhouse and find easy parking in a lot close by or on the street. You won't need to save up for a trip to Kelly's Roadhouse — most meals cost less than $15.1550 W Old Highway RdMorgan, UT US


text: by Jim Boyle Editor Sherburne County Attorney Kathleen Heaney has the unenviable but important task of sending troubled young men to Lino Lakes when they mess up. It's costly. The daily rate minimum-security detention is about $146, she says. Those sent to a more secure facility ring up a $236 bil...Read More


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Publications (29)263.8 Total impact
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Article: Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality.[Show abstract] [Hide abstract]
ABSTRACT: Identifying new targeted therapies that kill tumor cells while sparing normal tissue is a major challenge of cancer research. Using a high-throughput chemical synthetic lethal screen, we sought to identify compounds that exploit the loss of the von Hippel-Lindau (VHL) tumor suppressor gene, which occurs in about 80% of renal cell carcinomas (RCCs). RCCs, like many other cancers, are dependent on aerobic glycolysis for ATP production, a phenomenon known as the Warburg effect. The dependence of RCCs on glycolysis is in part a result of induction of glucose transporter 1 (GLUT1). Here, we report the identification of a class of compounds, the 3-series, exemplified by STF-31, which selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells on GLUT1 for survival. Treatment with these agents inhibits the growth of RCCs by binding GLUT1 directly and impeding glucose uptake in vivo without toxicity to normal tissue. Activity of STF-31 in these experimental renal tumors can be monitored by [(18)F]fluorodeoxyglucose uptake by micro-positron emission tomography imaging, and therefore, these agents may be readily tested clinically in human tumors. Our results show that the Warburg effect confers distinct characteristics on tumor cells that can be selectively targeted for therapy.Science translational medicine 08/2011; 3(94):94ra70. DOI:10.1126/scitranslmed.3002394 · 14.41 Impact Factor
Article: 4-Pyridylanilinothiazoles That Selectively Target von Hippel-Lindau Deficient Renal Cell Carcinoma Cells by Inducing Autophagic Cell Death[Show abstract] [Hide abstract]
ABSTRACT: Renal cell carcinomas (RCC) are refractory to standard therapy with advanced RCC having a poor prognosis; consequently treatment of advanced RCC represents an unmet clinical need. The von Hippel-Lindau (VHL) tumor suppressor gene is mutated or inactivated in a majority of RCCs. We recently identified a 4-pyridyl-2-anilinothiazole (PAT) with selective cytotoxicity against VHL-deficient renal cells mediated by induction of autophagy and increased acidification of autolysosomes. We report exploration of structure-activity relationships (SAR) around this PAT lead. Analogues with substituents on each of the three rings, and various linkers between rings, were synthesized and tested in vitro using paired RCC4 cell lines. A contour map describing the relative spatial contributions of different chemical features to potency illustrates a region, adjacent to the pyridyl ring, with potential for further development. Examples probing this domain validated this approach and may provide the opportunity to develop this novel chemotype as a targeted approach to the treatment of RCC.Journal of Medicinal Chemistry 12/2009; 53(2):787-97. DOI:10.1021/jm901457w · 5.48 Impact Factor
Article: Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment[Show abstract] [Hide abstract]
ABSTRACT: Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the tumor and their contribution to the tumor vasculature is poorly understood. Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth. These two factors are regulated by PHD2 in a HIF-independent but NF-kappaB-dependent manner. PHD2 levels are decreased in human cancers, compared with corresponding normal tissue, and correlate with an increase in mature blood vessels. Thus, PHD2 plays a critical role in regulating tumor angiogenesis.Cancer cell 07/2009; 15(6):527-38. DOI:10.1016/j.ccr.2009.04.010 · 23.89 Impact Factor
Article: Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: A novel molecule that induces autophagic cell death[Show abstract] [Hide abstract]
ABSTRACT: Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor suppressor gene von Hippel-Lindau (VHL). We exploited the possibility of targeting VHL-deficient RCC through synthetic lethality using a high-throughput screening approach. In this screen, STF-62247 was identified to be selectively toxic and growth inhibitory to renal cells lacking VHL. We recently demonstrated that the cytotoxicity of STF-62247 is due to dysregulated autophagy. Furthermore, the reduction of protein levels of essential autophagy pathway components such as Atg5, Atg7 and Atg9 reduces sensitivity of VHL-deficient cells to killing by STF-62247. Loss of proteins involved in Golgi trafficking sensitized RCC with wild-type VHL to killing by STF-62247, indicating a potential role for these proteins as a target of the compound. Our study supports the concept of using synthetic lethality to selectively kill VHL-deficient cells that represents a new type of targeted therapy for the treatment of RCC.Autophagy 11/2008; 4(7):944-6. DOI:10.4161/auto.6785 · 11.42 Impact Factor
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ABSTRACT: Renal cell carcinomas (RCCs) are refractory to standard therapies. The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in 75% of RCCs. By screening for small molecules selectively targeting VHL-deficient RCC cells, we identified STF-62247. STF-62247 induces cytotoxicity and reduces tumor growth of VHL-deficient RCC cells compared to genetically matched cells with wild-type VHL. STF-62247-stimulated toxicity occurs in a HIF-independent manner through autophagy. Reduction of protein levels of essential autophagy pathway components reduces sensitivity of VHL-deficient cells to STF-62247. Using a yeast deletion pool, we show that loss of proteins involved in Golgi trafficking increases killing by STF-62247. Thus, we have found a small molecule that selectively induces cell death in VHL-deficient cells, representing a paradigm shift for targeted therapy.Cancer cell 08/2008; 14(1):90-102. DOI:10.1016/j.ccr.2008.06.004 · 23.89 Impact Factor
Article: Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice.[Show abstract] [Hide abstract]
ABSTRACT: Tumor hypoxia plays a crucial role in tumorigenesis. Under hypoxia, hypoxia-inducible factor 1 alpha (HIF-1 alpha) regulates activation of genes promoting malignant progression. Under normoxia, HIF-1 alpha is hydroxylated on prolines 402 and 564 and is targeted for ubiquitin-mediated degradation by interacting with the von Hippel-Lindau protein complex (pVHL). We have developed a novel method of studying the interaction between HIF-1 alpha and pVHL using the split firefly luciferase complementation-based bioluminescence system in which HIF-1 alpha and pVHL are fused to amino-terminal and carboxy-terminal fragments of the luciferase, respectively. We demonstrate that hydroxylation-dependent interaction between the HIF-1 alpha and pVHL leads to complementation of the two luciferase fragments, resulting in bioluminescence in vitro and in vivo. Complementation-based bioluminescence is diminished when mutant pVHLs with decreased affinity for binding HIF-1 alpha are used. This method represents a new approach for studying interaction of proteins involved in the regulation of protein degradation.Molecular Imaging 01/2008; 7(3):139-46. · 2.19 Impact Factor
Article: Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells[Show abstract] [Hide abstract]
ABSTRACT: Late-stage clear cell renal carcinoma poses a formidable clinical challenge due to the high mortality rate associated with this disease. Molecular and genetic studies have identified functional loss of the von Hippel-Lindau (VHL) gene as a frequent and crucial event in the development of the malignant phenotype of clear cell renal carcinomas. Loss of VHL function thus represents a pathognomonic molecular defect for therapeutic exploitation. The objective of this study was to evaluate the possibility of targeting VHL loss through pharmacologic means. Chromomycin A3 (ChA3) was identified through in silico analysis of existing publicly available drug profiles from the National Cancer Institute as an agent that seemed to selectively target VHL-deficient clear cell renal carcinoma cells. Genotype-selective toxicity was first determined through short-term viability assays and then confirmed with clonogenic studies. Coculture of fluorescently labeled VHL-deficient and VHL-positive cells showed discriminate killing of the VHL-deficient cells with ChA3. Mechanistically, overexpression of hypoxia-inducible factor (HIF)-2alpha in VHL-positive clear cell renal carcinoma cells phenocopied loss of VHL with respect to ChA3 toxicity, establishing ChA3 as a HIF-dependent cytotoxin. This study shows the feasibility of selectively targeting the loss of the VHL tumor suppressor gene in clear cell renal carcinoma for potential clinical benefit and may have greater ramifications in the development of new targeted therapies for the treatment of cancer and other genetic diseases.Cancer Research 07/2007; 67(12):5896-905. DOI:10.1158/0008-5472.CAN-07-0604 · 9.28 Impact Factor
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ABSTRACT: The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2007 issue of Cancer Cell, Zhang and colleagues determine that the hypoxia-inducible factor family of transcriptional factors regulate mitochondrial biogenesis through inhibition of C-MYC.Developmental Cell 07/2007; 12(6):845-6. DOI:10.1016/j.devcel.2007.05.006 · 10.37 Impact Factor
Article: Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy.[Show abstract] [Hide abstract]
ABSTRACT: Solid tumors frequently contain large regions with low oxygen concentrations (hypoxia). The hypoxic microenvironment induces adaptive changes to tumor cell metabolism, and this alteration can further distort the local microenvironment. The net result of these tumor-specific changes is a microenvironment that inhibits many standard cytotoxic anticancer therapies and predicts for a poor clinical outcome. Pharmacologic targeting of the unique metabolism of solid tumors could alter the tumor microenvironment to provide more favorable conditions for anti-tumor therapy. Here, we describe a strategy in which the mitochondrial metabolism of tumor cells is increased by pharmacologic inhibition of hypoxia-inducible factor 1 (HIF1) or its target gene pyruvate dehydrogenase kinase 1 (PDK1). This acute increase in oxygen consumption leads to a corresponding decrease in tumor oxygenation. Whereas decreased oxygenation could reduce the effectiveness of some traditional therapies, we show that it dramatically increases the effectiveness of a hypoxia-specific cytotoxin. This treatment strategy should provide a high degree of tumor specificity for increasing the effectiveness of hypoxic cytotoxins, as it depends on the activation of HIF1 and the presence of hypoxia, conditions that are present only in the tumor, and not the normal tissue.Proceedings of the National Academy of Sciences 06/2007; 104(22):9445-50. DOI:10.1073/pnas.0611662104 · 9.81 Impact Factor
Article: Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia.[Show abstract] [Hide abstract]
ABSTRACT: Reporter gene techniques have been applied toward studying the physiologic phenomena associated with tumor hypoxia, a negative prognostic indicator. The purpose of this study was to assess the potential adverse effects of hypoxic conditions on the effectiveness of four commonly used reporter genes: Renilla luciferase, monomeric red fluorescent protein, thymidine kinase, and lacZ. Tumor-forming A375 cells expressing a trifusion reporter consisting of Renilla luciferase, monomeric red fluorescent protein, and thymidine kinase were subjected to decreasing oxygen tensions and assayed for reporter expression and activity. A375 cells expressing beta-galactosidase were similarly exposed to hypoxia, with activity of the reporter monitored by cleavage of the fluorescent substrate 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one)-beta-galactoside (DDAOG). Generation of signal in in vivo tumor models expressing bioluminescent or beta-galactosidase reporters were also examined over the course of hypoxic stresses, either by tumor clamping or the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Our findings indicate that bioluminescent and fluorescent reporter activity are decreased under hypoxia despite minimal variations in protein production, whereas beta-galactosidase reporter activity per unit protein was unchanged. These results demonstrate that combining beta-galactosidase with the DDAOG optical probe may be a robust reporter system for the in vivo study of tumor hypoxia.Molecular Imaging 01/2007; 6(4):219-28. · 2.19 Impact Factor
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ABSTRACT: To confirm the relationship between plasma osteopontin (OPN) levels and treatment outcomes in head and neck squamous cell carcinoma (HNSCC) patients in an expanded study. One hundred forty patients with newly diagnosed HNSCC were enrolled onto this study, 54 previously reported and 86 new patients. Pretreatment plasma OPN levels were assessed in all patients by an enzyme-linked immunosorbent assay method. OPN levels were correlated to treatment outcomes in the new group of patients. Detailed analyses were also performed on the relationship between OPN and tumor control rate, event-free survival (EFS), and postrelapse survival for the entire group. Using a previously defined cut off point of 450 ng/mL, there was a significant correlation between OPN and freedom-from-relapse (P = .047), overall survival (P = .019), and EFS (P = .023) in the new, independent patient cohort (n = 86). Sequence of event analyses using the entire group (N = 140) revealed that OPN was an independent prognostic factor for initial tumor control, EFS in those who have achieved tumor control, and postrelapse survival. In this expanded study, we were able to replicate the prognostic significance of OPN using a predefined cut off point in an independent patient group and demonstrated that plasma OPN is an independent prognostic marker for HNSCC.Journal of Clinical Oncology 12/2006; 24(33):5291-7. DOI:10.1200/JCO.2006.06.8627 · 17.88 Impact Factor
Article: Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis[Show abstract] [Hide abstract]
ABSTRACT: Pancreatic cancer is highly aggressive and refractory to most existing therapies. Past studies have shown that connective tissue growth factor (CTGF) expression is elevated in human pancreatic adenocarcinomas and some pancreatic cancer cell lines. To address whether and how CTGF influences tumor growth, we generated pancreatic tumor cell lines that overexpress different levels of human CTGF. The effect of CTGF overexpression on cell proliferation was measured in vitro in monolayer culture, suspension culture, or soft agar, and in vivo in tumor xenografts. Although there was no effect of CTGF expression on proliferation in two-dimensional cultures, anchorage-independent growth (AIG) was enhanced. The capacity of CTGF to enhance AIG in vitro was linked to enhanced pancreatic tumor growth in vivo when these cells were implanted s.c. in nude mice. Administration of a neutralizing CTGF-specific monoclonal antibody, FG-3019, had no effect on monolayer cell proliferation, but blocked AIG in soft agar. Consistent with this observation, anti-CTGF treatment of mice bearing established CTGF-expressing tumors abrogated CTGF-dependent tumor growth and inhibited lymph node metastases without any toxicity observed in normal tissue. Together, these studies implicate CTGF as a new target in pancreatic cancer and suggest that inhibition of CTGF with a human monoclonal antibody may control primary and metastatic tumor growth.Cancer Research 07/2006; 66(11):5816-27. DOI:10.1158/0008-5472.CAN-06-0081 · 9.28 Impact Factor
Conference Paper: Molecular imaging of HIF-1 alpha and pVHL interaction in living subjects using firefly luciferase complementation - Improvement over the Renilla luciferase system48th Annual Meeting of the; 01/2006
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ABSTRACT: Osteopontin (OPN) is a secreted phosphoglycoprotein that has been linked to tumor progression and survival in several solid tumors, including head and neck cancers. Previous studies showed that OPN expression is induced by tumor hypoxia, and its plasma levels can serve as a surrogate marker for tumor hypoxia and treatment outcome in head and neck cancer patients. In this study, we investigate the transcriptional mechanism by which hypoxia enhances OPN expression. We found that OPN is induced in head and neck squamous cell carcinoma (HNSCC) cell lines and in NIH3T3 cells by hypoxia at both mRNA and protein levels in a time-dependent manner. Actinomycin D chase experiments showed that hypoxic induction of OPN was not due to increased mRNA stability. Deletion analyses of the mouse OPN promoter regions indicated that a ras-activated enhancer (RAE) located at -731 to -712 relative to the transcription start site was essential for hypoxia-enhanced OPN transcription. Using electrophoretic mobility shift assays with the RAE DNA sequence, we found that hypoxia induced sequence-specific DNA-binding complexes. Furthermore, hypoxia and ras exposure resulted in an additive induction of OPN protein and mRNA levels that appeared to be mediated by the RAE. Induction of OPN through the RAE element by hypoxia is mediated by an Akt-kinase signaled pathway as decreasing Akt levels with dominant negative constructs resulted in inhibition of OPN induction by hypoxia. Taken together, these results have identified a new hypoxia responsive transcriptional enhancer that is regulated by Akt signaling.Oncogene 10/2005; 24(43):6555-63. DOI:10.1038/sj.onc.1208800 · 8.56 Impact Factor
Article: Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.[Show abstract] [Hide abstract]
ABSTRACT: Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains two highly conserved oxygen-dependent degradation domains (402 ODD and 564 ODD), each of which includes a proline that is hydroxylated in the presence of oxygen, allowing the von Hippel-Lindau (VHL) E3 ubiquitin ligase to interact and target HIF-1alpha to the proteasome for degradation. Mutation of either proline is sufficient to partially stabilize HIF-1alpha under conditions of normoxia, but the specific contributions of each hydroxylation event to the regulation of HIF-1alpha are unknown. Here we show that the two ODDs of HIF-1alpha have independent yet interactive roles in the regulation of HIF-1alpha protein turnover, with the relative involvement of each ODD depending on the levels of oxygen. Using hydroxylation-specific antibodies, we found that under conditions of normoxia proline 564 is hydroxylated prior to proline 402, and mutation of proline 564 results in a significant reduction in the hydroxylation of proline 402. Mutation of proline 402, however, has little effect on the hydroxylation of proline 564. To determine whether the more rapid hydroxylation of the proline 564 under conditions of normoxia is due to a preference for the particular sequence surrounding proline 564 or for that site within the protein, we exchanged the degradation domains within the full-length HIF-1alpha protein. In these domain-swapping experiments, prolyl hydroxylase domain 1 (PHD1) and PHD2 preferentially hydroxylated the proline located in the site of the original 564 ODD, while PHD3 preferred the proline 564 sequence, regardless of its location. At limiting oxygen tensions, we found that proline 402 exhibits an oxygen-dependent decrease in hydroxylation at higher oxygen tensions relative to proline 564 hydroxylation. These results indicate that hydroxylation of proline 402 is highly responsive to physiologic changes in oxygen and, therefore, plays a more important role in HIF-1alpha regulation under conditions of hypoxia than under conditions of normoxia. Together, these findings demonstrate that each hydroxylated proline of HIF-1alpha has a distinct activity in controlling HIF-1alpha stability in response to different levels of oxygenation.Molecular and Cellular Biology 09/2005; 25(15):6415-26. DOI:10.1128/MCB.25.15.6415-6426.2005 · 5.04 Impact Factor
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ABSTRACT: Mammalian oxygen homeostasis is dependent on the HIF family of transcription factors. The CSN subunit, CSN5, binds both the CODD of HIF-1 alpha and the pVHL tumor suppressor. High CSN5 expression generates a pVHL-independent form of CSN5 that stabilizes HIF-1 alpha aerobically by inhibiting HIF-1 alpha prolyl-564 hydroxylation. Aerobic CSN5 association with HIF-1 alpha occurs independently of the CSN holocomplex, leading to HIF-1 alpha stabilization independent of Cullin 2 deneddylation. CSN5 weakly associates with HIF-1 alpha under hypoxia, but is required for optimal hypoxia-mediated HIF-1 alpha stabilization. These results indicate that CSN5 regulates aerobic as well as hypoxic HIF-1 alpha stability by different mechanisms during oncogenesis.Genes & Development 05/2004; 18(7):739-44. DOI:10.1101/gad.1180104 · 12.64 Impact Factor
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ABSTRACT: Elimination or reduction of tumor burden is the primary goal of cancer therapy. Strategies to achieve this goal with the fewest adverse effects to the patient are an area of intense investigation. Elevated protein levels of hypoxia-inducible factor (HIF) are commonly found in solid tumors, while rarely found in healthy tissue. Numerous studies have suggested that HIF activity is essential for the development of solid tumors. Thus, inhibition of HIF represents an attractive therapeutic target for eradicating tumors. The search for small molecules that target and inhibit HIF activity is currently underway. We propose an alternate approach: to directly target and kill HIF-activated tumor cells. This approach is advantageous in that cells with activated HIF will be eliminated directly. Specific elimination of HIF-activated cells represents a potential mechanism for inhibiting tumor growth, with the potential advantage of sparing the patient of the normal tissue toxicity associated with current treatment options.Cell cycle (Georgetown, Tex.) 03/2004; 3(2):160-3. DOI:10.4161/cc.3.2.617 · 5.01 Impact Factor
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ABSTRACT: Clinical evidence shows that tumor hypoxia is an independent prognostic indicator of poor patient outcome. Hypoxic tumors have altered physiologic processes, including increased regions of angiogenesis, increased local invasion, increased distant metastasis and altered apoptotic programs. Since hypoxia is a potent controller of gene expression, identifying hypoxia-regulated genes is a means to investigate the molecular response to hypoxic stress. Traditional experimental approaches have identified physiologic changes in hypoxic cells. Recent studies have identified hypoxia-responsive genes that may define the mechanism(s) underlying these physiologic changes. For example, the regulation of glycolytic genes by hypoxia can explain some characteristics of the Warburg effect. The converse of this logic is also true. By identifying new classes of hypoxia-regulated gene(s), we can infer the physiologic pressures that require the induction of these genes and their protein products. Furthermore, these physiologically driven hypoxic gene expression changes give us insight as to the poor outcome of patients with hypoxic tumors. Approximately 1-1.5% of the genome is transcriptionally responsive to hypoxia. However, there is significant heterogeneity in the transcriptional response to hypoxia between different cell types. Moreover, the coordinated change in the expression of families of genes supports the model of physiologic pressure leading to expression changes. Understanding the evolutionary pressure to develop a 'hypoxic response' provides a framework to investigate the biology of the hypoxic tumor microenvironment.Oncogene 10/2003; 22(37):5907-14. DOI:10.1038/sj.onc.1206703 · 8.56 Impact Factor
Article: Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas.[Show abstract] [Hide abstract]
ABSTRACT: Tumor hypoxia modifies treatment efficacy and promotes tumor progression. Here, we investigated the relationship between osteopontin (OPN), tumor pO(2), and prognosis in patients with head and neck squamous cell carcinomas (HNSCC). We performed linear discriminant analysis, a machine learning algorithm, on the NCI-60 cancer cell line microarray expression database to identify a gene profile that best distinguish cell lines with high Von-Hippel Lindau (VHL) gene expression, an important regulator of hypoxia-related genes, from those with low expression. Plasma OPN levels in 15 volunteers, 31 VHL patients, and 54 HNSCC patients were quantitatively measured by ELISA. The relationships between plasma OPN levels, tumor pO(2) as measured by the Eppendorf microelectrode, freedom from relapse (FFR), and survival in HNSCC patients were evaluated. Microarray analysis indicated that OPN gene expression inversely correlated with that of VHL. These findings were confirmed by Northern blot analysis. ELISA studies and Western blot in a HNSCC cell line demonstrated that hypoxia exposure resulted in increased OPN secretion. Patients with VHL syndrome had significantly higher plasma OPN levels than healthy volunteers. Plasma OPN level inversely correlated with tumor pO(2) (P = 0.003, r = -0.42). OPN levels correlated with clinical outcomes. The 1-year FFR and survival rates were 80 and 100%, respectively, for patients with OPN levels <or=450 ng/ml and 43 and 63%, respectively, for levels >450 ng/ml (P = 0.002 and 0.0005). Multivariate analysis revealed that OPN was an independent predictor for FFR and survival. Plasma OPN levels appeared to correlate with tumor hypoxia in HNSCC patients and may serve as noninvasive tests to identify patients at high risk for tumor recurrence.Clinical Cancer Research 01/2003; 9(1):59-67. · 8.19 Impact Factor
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ABSTRACT: Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a regulator of gene expression under low oxygen conditions. Here, employing a novel hydroxylation-specific antibody, we directly show that proline 564 of HIF-1alpha and proline 531 of HIF-2alpha are hydroxylated under normoxia. Importantly, HIF-1alpha Pro-564 and HIF-2alpha Pro-531 hydroxylation is diminished with the treatment of hypoxia, cobalt chloride, desferrioxamine, or dimethyloxalyglycine, regardless of the E3 ubiquitin ligase activity of the von Hippel-Lindau (VHL) tumor suppressor gene. Furthermore, in VHL-deficient cells, HIF-1alpha Pro-564 and HIF-2alpha Pro-531 had detectable amounts of hydroxylation following transition to hypoxia, indicating that the post-translational modification is not reversible. The introduction of v-Src or RasV12 oncogenes resulted in the stabilization of normoxic HIF-1alpha and the loss of hydroxylated Pro-564, demonstrating that oncogene-induced stabilization of HIF-1alpha is signaled through the inhibition of prolyl hydroxylation. Conversely, a constitutively active Akt oncogene stabilized HIF-1alpha under normoxia independently of prolyl hydroxylation, suggesting an alternative mechanism for HIF-1alpha stabilization. Thus, these results indicate distinct pathways for HIF-1alpha stabilization by different oncogenes. More importantly, these findings link oncogenesis with normoxic HIF-1alpha expression through prolyl hydroxylation.Journal of Biological Chemistry 11/2002; 277(42):40112-7. DOI:10.1074/jbc.M206922200 · 4.60 Impact Factor
Top Journals
Massachusetts General HospitalBoston, Massachusetts, United States
Stanford University
Palo Alto, California, United States
- Department of Radiation Oncology
Stanford Medicine
Stanford, California, United States
- • Department of Radiation Oncology
- • Division of Radiation and Cancer Biology


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Why was Kes written off the show?
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March 7 2012, 08:29 AM
Guy Gardener
Fleet Admiral
Location: In the lap of squalor I assure you.
Re: Why was Kes written off the show?
teacake wrote:
Guy Gardener wrote:
Once they saw how that worked, they could just keep firing actors till it's just seven and the doctor and a mountain of sfx.
You left someone out.
My cogent paradigm was intended to illustrate that TPTB are batshit.
And Therin, if most men were capable if identifying "wigs" as ridiculous and obvious, women wouldn't bother with them because they'd be fools to want to seem ridiculous and obvious, and as a certain aside, if most men could identify wigs as ridiculous and obvious the toupee industry would be bankrupt yesterday.
So what's Teacakes excuse for being suckered by a ridiculous and obvious wig, since she's part of the conspiracy to temporarily retrofit women to the detriment of a competing sex?
"Glitter is the herpes of arts and craft."
Troy Yingst. My Life as Liz
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Observations on the Effects of the Corn LawsElectric Book Company 1998; US$ 4.95
Malthus is most famous as the inventor of a simple equation between population and food supply. In this treatise Malthus states the arguments for and against the protection of agriculture, holding the balance between the two opinions, but hinting that the political dependence caused by free trade was a serious evil, and that agriculture was more... more...
Enterprise and CultureTaylor and Francis 2002; US$ 54.95
Enterprise and Culture is a uniquely wide-ranging, insightful and well-informed critical evaluation of the economic and social project of creating an enterprise culture. Colin Gray argues that the failure of small enterprise policy is not just a question of economics, but is also caused by psychological and cultural factors. The book demonstrates... more...


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B.Tech(IT), 3.6 yrs experience in Cobol,vsam,db2,jcl,testing
India - Last active: 4 days ago - Tests: 4
I have completed my graduation (B.TECH in IT). Worked as mainframe developer for 3 years and 6 months in a multi national company . Had experience in insurance domain. Developed projects for corporate billing . Have got trained in communication skills. Am interested in freelancing jobs. I am eager to involve myself and Do a perfect job.
Senior Programmer Visual Basic,VBA,Excel,Access,SQL,Essbase,Mainframe
Argentina - Last active: 19 hours ago - Tests: 2 - Portfolio: 12
My Degree: More than 15 years of experience working for 1st level enterprises. My Speciality: Solve problems. My Proof: See my oDesk work history and feedback
- JavaScript
- SAP Crystal Reports
- .NET Framework
- Oracle Hyperion Planning
- Visual Basic
- Lotus Notes
- Microsoft Access Administration
- dBase Administration
- Adobe Flash
- Microsoft SQL SSRS
- Microsoft Excel
Groups: Yahoo Web Hosting Designer
Associated with: Hipnotika Agency
Mainframe Analyst/Quality Analyst/Data Entry/Customer Service
Philippines - Last active: 19 hours ago - Tests: 8 - Portfolio: 3
I am an experienced mainframe programmer/analyst. Skills: COBOL, ITEQ/BTEQ, DBC, EZT+, Unify, JCL, DB2, VSAM, VBScript, SAS. I have also worked as a technical support representative and quality analyst at various call centers. While studying, I have worked as a part-time admin clerk, receptionist, data encoder, and library student assistant. I am quite efficient with my work and can complete my tasks in a timely manner and with minimum supervision. I can type accurately with a speed of 45 WPM. I am currently looking for a home-based position that would suit my capabilities.
Project Manager
India - Last active: 1 month ago - Tests: 5 - Portfolio: 9
Over the last 6 years, I have managed projects in the banking and insurance sectors for a wide range of technology stacks for world class institutions. My strong skills are in managing to deliver projects on time and on budget with very good stakeholder management. Excellent communication and interpersonal skills make this happen for me. I am also adept at requirement gathering, testing, training users and completing functional and technical documents. A brief description of my exposure in IT follows:IT Work Experience: 22+ Years (Sept 1985 to March 2009)Project Types: Development, Conversion, Maintenance & EnhancementRoles Held from most recent to oldest: Technology Project Manager, Project Manager/PMO, Project Lead (with parallel roles of Internal Auditor and SQA/SQA Team Lead), Onsite Coordinator, Analyst, Developer and Tester.Technical Skills DBMS: Oracle, IDMS, DB2, FoxProFront End/GUI: ADSO, CICS, Oracle 7.1, Forms 4.5Languages: COBOL, JCL, PRO*C, PRO*COBOL, FOCUS, XMLOS/Environment:MVS, UNIX, Win 95/98, Win NT, Win2K,MS- DOS, Soft/Intervoice, ApplicationViewTraining ProfilePMP Certification - Aug 2010SAP ABAP Certification - Apr 2010PMP Certification Examination Preparatory 35 Hrs Course - March 14,15,21,22 - 2009 - Full-time conducted by PMI Mumbai ChapterCertificate in Computing, IGNOU, India (Distant Learning and Mandatory qualifier for admission to MCA, IGNOU) Jan - Jun 2005 - Full-timeSAP (Business Information Warehouse) Nov 2004 Jan 2005 Part-timeGreen Belt (Six Sigma) June 2001 Full-TimeManufacturing Resource Planning, Aug 1997 NITIE, India Full- timeIBM Mainframes (MVS/JCL, IDMS, ADSO, DB2, CICS) Jan-Mar 1997Powerbuilder 4.0, July 1996 (Full-time), Unix, C, Oracle 7.1 with Developer 2000 Forms 4.5 and Reports 2.5, July Oct 1996 Full-timeVAX/VMS ON-LINE Transaction Processing Certificate Course in 1991 SepNov 1991 - Full-timeEDP Fundamentals and COBOL Programming Certificate course, Oct 1984 to Jan 1985 - Full- timeCertifications: IBM SOA (Service Oriented Architecture) Associate 2006 and 2008
Systems & Database Administrator, DBA, Oracle,SQL Server,Postgresql
United States - Last active: 09/27/2013 - Tests: 4
Information Technology professional with expertise in Database Management, Network Administration, Quality Assurance. Self-starter, detail oriented with strong leadership analytical, problem solving, communication and relationship management skills.
senior developer (multiple languages)
Spain - Last active: 03/13/2014 - Tests: 18
I am looking for projects to provide solutions in few technologies: - Web, client side: DHTML, DOM, Javascript, AJAX, SVG, HTML5 - Web, server side: PHP, MySQL, CMS: Magento - Desktop: C, C++, .NET, VB, VBA, etc. - Host: Natural/Adabas, JCL, Cobol, PL/1.
Mainframe Software Developer
Philippines - Last active: 3 days ago - Tests: 5 - Portfolio: 4
To continue exploring opportunities so I could offer my skills and learn more as well. Has 8 years solid working experience as Mainframe Analyst, Tester, and Developer in the Philippines and Singapore.
Excel, Word, Powerpoint, English language expert
India - Last active: 19 hours ago - Tests: 5
- 8 years experience in the Information Technology industry. - Excellent skills in MS Excel, MS Word, MS Powerpoint. - Very good English language and proof-reading skills. - Adept in data entry and typing. - Great analytical and Mathematics skills.
Mainframe Developer/ Analyst
India - Last active: 2 months ago - Tests: 2
I have close to 6 years of experience in Mainframe technologies which includes development/maintenance experience in various enterprise systems based on IBM/HP mainframes like Tandem and Open VMS technologies. My professional history includes positions such as Technology Analyst for 3 yrs and senior developer for about 3 years in Infosys technologies limited, India.
Philippines - Last active: 21 days ago - Tests: 9
To have a home based part time job


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Since 1971, Schlotzsky's(R) has been the home of The Original(R) toasted sandwich. The menu has evolved with customers' tastes to include the highest quality sandwiches, pizzas, salads, and soups available today. With approximately 365 locations worldwide, Schlotzsky's is the fast-casual choice for a quick, healthful, and fresh dining experience. For additional information and locations near you, visit http://www.schlotzskys.com .
About Young Men's Business League of Austin
Founded in 1913, the Young Men's Business League of Austin (YMBL) is one of the oldest and most respected social service organizations in the city. It enables men to grow professionally by working with others toward a common mission: "To provide programs for deserving children in Austin and the surrounding area, which aid in their professional development and teach the skills necessary to succeed in school and in life. In short, we are a non- profit, non-political organization, dedicated to taking the risk out of Austin's at-risk youth." For more information, visit http://www.austinymbl.org .
About Austin Sunshine Camps
Established in 1928 by the Young Men's Business League of Austin
(YMBL), the Austin Sunshine Camps (ASC) have been providing a safe and
nurturing environment for the disadvantaged boys and girls of Central Texas
for almost eighty years. Organizers work with the children in summer camps
and year-long programs to develop the tools necessary to overcome the
variety of difficulties they face in their day-to-day lives. The children
are assailed on all fronts from challenges of poverty and family
disintegration to the threats of drug and violence. ASC's ultimate goal is
to eliminate the high school dropout rate among the at-risk youths they
target and increase college participation by these same young men and women
to help break the poverty c
|SOURCE Schlotzsky's
Copyright©2008 PR Newswire.
All rights reserved


text:
Lots of gf options that actually taste good. Everything was marked on the menu and the staff was knowledgable and helpful.
Amazing GF options!
Found this place by accident looking for a good variety of gluten free foods as my daughter is highly allergic.Not only do they have a wide selection but the food is wonderful. Not to mention the place is a great place for a romantic meal. eat by the fire!! Ask for Skylar he is the most wonderful waiter!! Cant recommend this place highly enough. If you like shrimp try the capitol shrimp. Maybe the BEST shrimp I have every had!!! We had seven of us and we all enjoyed our meals. Stop and go there NOW!! LOL ENJOY!!!
Great gf options, appetizers, soup, salad, steaks, pastas, seafood, dessert, etc. Staff was knowledgable, regular menu items were marked "gf." Food was delicious. Great atmosphere. Will definitely go back!
Capital Prime is a romantic steakhouse that caters to people with gluten free and vegetarian diets. They shop locally so the food is fresh and Michigan made. They have private dining rooms, take out, and happy hour.


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It might be easier to just throw some dirty sheets over it and tell her to wash the f**kin' sheets.
better idea tear the wrapping paper up in bits n throw it all over the house....Shell appreciate the new vacume even more LOL
My dad did that for Christmas. Mom was not amused even though it was a gag gift and had an expensive gold necklace in the bag. I swear my mom was possessed by a demon by the way she reacted. Now, imagine if the gender was reversed and your wife bought you a self-propelled lawnmower. Personally, I'd jump for joy! I'd say if your wife has a sense of humor, go for it. Otherwise, don't even think about it.
No, she'll do a good job of wrapping it round your neck soon enough...
No it would suck taking all that paper off of it.
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A resident walks in to the town offices in Shirley to vote in the town-wide election on Tuesday.
Welcome to your discussion forum: Sign in with a Disqus account or your social networking account for your comment to be posted immediately, provided it meets the guidelines. (READ HOW.) Comments made here are the sole responsibility of the person posting them; these comments do not reflect the opinion of The Sentinel and Enterprise. So keep it civil.
Man jailed for not paying $749 fare for 300-mile cab ride
UNIONTOWN, Pa. (AP) — Police say a man who took a 300-mile cab ride across Pennsylvania to surprise his fiancee has been jailed because he couldn't pay the $749 fare. Full Story
'Glee'-type music contest crowns winners in New York City
NEW YORK (AP) — A Californian and a New Yorker have won top honors at the National High School Musical Theater Awards. Full Story
(Photo by Laura Segall/ Getty)
Bristol Palin now says pregnancy was planned
Daughter of Sarah Palin fired back at critics, after announcing last week she was pregnant.


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