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Revlon Colorburst Lip Butter - Berry Smoothie
173 reviews
80% would repurchase
Package Quality: 3.9
Price: $$
Package Quality: 3.9
Price: $$
on 1/28/2014 7:12:00 PM
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Black, Other, Other
Eyes: Brown
My favourite lipstick of all time! Which is saying a lot because I have a huge collection of lippies and many favourites. But this is the best of the best for me. It's a beautiful berry shade that complements my fair-medium skin tone perfectly. It's an everyday, super wearable MLBB (my lips but better) shade that would flatter many skin tones.
It goes on super smooth and buttery, as the name suggests, and keeps my lips hydrated. The staying power is decent- around 4 hours? If you eat you will need to re-apply, as with most lipsticks. But the staying power on this lipstick beats out many other drugstore lippies (ie: Maybelline Color Whisper).
This was the first Revlon Lip Butter I ever bought, over 2 years ago, and I still love it to this day. I barely wear any of the other shades that I bought. I'm actually quite close to finishing up my tube, which is a first- I've never finished up any other lipstick before! Goes to show how much I love this lipstick. Definitely worth a try!
on 1/23/2014 12:48:00 AM
Age: 30-35
Skin: Dry, Olive, Warm
Hair: Black, Curly, Medium
Eyes: Brown
Great Winter Shade
Price: About £8 from Boots (England) but often on a 3 for 2 offer. In Singapore I bought this for $9 SGD at the airport. Not a bad price at all for the quality and colour selection.
Packaging: Love how the lid is colour coordinated to the colour of the lipstick inside and how the top of the lid is clear so you can see the colour of the lipstick. A bit tricky to open at times as the lid is so long that there isn't much of a base to hold on to whilst pulling
the lid off!
Product: This is very moisturising like a lip balm, has a glossy sheen like a lip gloss and has the colour of a lipstick. A great combination of all 3 products in 1!!! This is my 5th lip butter and is the perfect fall / autumn / winter shade for someone like me who isn't a fan of the bold opaque berry lips that tend to make an appearance during the colder months.
Berry Smoothis is a gorgeous warm pink shade that has a sublte hint of purple on my lips. It does have teeny tiny shimmery flecks running through it, like Macaroon, but they're not as obvious or as chunky as in the Peach Parfait shade.The colour is sheer but buildable but not as opaque as Candy Apple Red or Wild Watermelon. The lip butter has a subtle cinema sweet popcorn scent that isn't bothersome and fades easily. Whilst I do like this shade it's not my favourite out of the 5 that I own. My favourite is definitely Candy Apple Red followed closely by Wild Watermelon as these two colours lift and brighten my complexion amazingly.
Lasts a good 6 hours depending on eating/drinking habits. Whilst the gloss like sheen may fade after a couple of hours, I find that the colour lasts for quite a few more hours and fades evenly. I only reapply this after I've eaten/drunk something otherwise I just let the colour fade naturally.
Not at all drying even when I've used it for several days in a row.
Great selection of colours and reasonably priced. Would definitely recommend especially if you're not a fan of very opaque lipsticks, like me.
GlisteningSheen xxx
on 1/21/2014 9:02:00 PM
Age: 19-24
Skin: Combination, Tan, Warm
Hair: Black, Other, Other
Eyes: Brown
Love love love this lip butter! It's definitely a hybrid between a lipstick and a lipgloss and I love it. This looks very natural on my lips. It's very close to my natural lip colour and it gives that effortless look, like I didn't take too long perfecting my lips. You can definitely put this on without looking in the mirror and that's a plus because we don't always have a mirror handy! It's very moisturizing and it has a sheen to it. I personally think it's perfect as a year-round lip product. As for the packaging, I think it's okay. It looks a bit juvenile with the obvious plastic packaging but I can look past that because the product itself is fantastic. I only buy Revlon lip products when they're on sale because in Canada, at least in my city, Revlon lipsticks can cost up to 10 bucks. But when they're on sale, they're just around 3.99, which is a steal! I'm looking forward to trying other lip butters from Revlon!
on 1/19/2014 5:35:00 PM
Age: 18 & Under
Skin: Oily, Olive, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
I love the Revlon lip butters in general, but this color wasn't my favorite. At first I loved it but it is a little to shimmery for me. Its very creamy and doesn't dry out your lips. You will have to reapply throughout the day, but I prefer comfort over long-lasting. The tube can get messy around the edges. I like this product just not my favorite of the line.
on 1/17/2014 8:05:00 PM
Age: 25-29
Skin: Acne-prone, Fair, Neutral
Hair: Brown, Other, Coarse
Eyes: Brown
A pretty muted pink shade, that is perfect for an everyday look. It mimics my natural lip colour but slightly glossier and with a bit of pink glitter flecks. It is moisturizing but not long wearing (3-4 hours without eating). Goes on a bit thick on the lips. It does not look as dark as it looks in the tube, don't be fooled!
on 1/12/2014 7:37:00 PM
Age: 25-29
Skin: Combination, Medium, Warm
Hair: Black, Wavy, Medium
Eyes: Black
Love this lip butter! This one and Pink Truffle are my favorite. Berry Smoothie gives my NC 40 skin the perfect pop of raspberry/pink. It goes on smooth and keeps my lips nicely hydrated. True to its name, it really does go on buttery. It also has a glossy finish, which I like.
on 1/4/2014 9:09:00 PM
Age: 19-24
Skin: Sensitive, Fair, Cool
Hair: Brunette, Curly, Medium
Eyes: Blue
I really like this formula- the color, texture. It's soft but the color is very natural for my skin, so I look as though I'm only wearing a dab of lipgloss. The texture is amazing. It's smooth and creamy but manages to avoid being sticky. I've been wearing this over matte lipsticks, and the effect is still delicate but beautiful. I'm able to wear this over three or four hours, which is something that rarely happens to me. It has a nice, sort of fruity scent; I was pleasantly surprised when my skin didn't react to the fragrance. The texture, though. It's just perfect and incredibly comfortable.
on 1/1/2014 1:00:00 PM
Age: 19-24
Skin: Normal, Fair, Not Sure
Hair: Brunette, Other, Other
Eyes: Green
i like the sheer berry color of this. it's perfect for those 'natural' no makeup up looks. it's like the natural color of my lips only a little deeper. perfect for work or when your wanting to make a bold smokey eye but need to down play the lips.
on 12/8/2013 3:11:00 PM
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Hazel
i am not a fan at all of lipstick or stains so i have been hunting for something that gives me a nice splash of color without overpowering my face. this lip butter is perfect. almost like a tinted balm but more pigmented. i love it. the price is good. the packaging is cute and convenient but the top tends to slip off in my purse. i can't say much on staying power as i compulsively reapply every hour like i would chapstick. that's just me, though. would definitely buy again.
on 12/8/2013 3:37:00 AM
Age: 18 & Under
Skin: Sensitive, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
Just got this yesterday and I'm loving it! It's the perfect colour for autumn/winter, especially for a teen that's just starting to wear darker lips! It's similar to my natural lip colour, but a little darker with purple undertones, hence the name berry smoothie! It goes on very smoothly and it makes my lips look nice and glossy as well. 5 stars!
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subset: commoncrawl


text:
In response to Harvey-Wallbanger's comment:
In response to UD6's comment:
In response to Harvey-Wallbanger's comment:
^This was supposed to be a counter to MArvin Harrison assualting two people (one a child) in the streets of Philly or Aldon Smith doing it?
Talk about a fail, Underpanties.
Don't try to change the subject, troll. This is about Aldon Smith and the Anti-Patriot world at large. This has nothing to do with Marvin Harrisoon. Besides, we ALL know that Marvin Harrison wasn't charged with any crime, let alone murder, because the Philly prosecutor hates the Patriots.
I am laughing at you and your ineptitude and inability to understand something so simple. Forget the GED, your not ready for that. You need remedial reading and probably toilet training.
Rusty owned.
Umm, what?
I am trying to change the subject as you swoop in to troll this thread as a COlts fan because you know I am right?
Are you denying the media hates Bill Belichick and THAT is the reason for the media overly-obsessing over every issue, regardless of how big or small?
Tell us, Underpanties.
Why can't I find one article on the Denver Broncos atrocious defense in 2013, which is worse than their poor defense in 2012?
Can you exlplain that?
I would never deny that the media hates Belichick. nearly the entire world hates Belichick. It as obvious as the sky is blue. The impetus for nearly all action or non-action throughout the world is in response to hatred for Bill Belichick. Its obvious. Anyone with a brain knows this is why Smith hasn't been charged with Murder. We know this is why Harrison hasn't been charged with Murder.
The only reason no one is talking about how poor the Denver defense is has nothing at all to do with Manning's historic fireworks on the other side of the ball, its because the media hates belichick. In Indiana, the local media write about the colts, not because they are a local team, but because the media hates belichick.
I got it. I am onboard. We are going to beat this drum until the sticks breaks, arms fall off, or ear drums burst.


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My new KTM 990/Why I cancelled a Winter riding Mexico
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Gnarly Adventurer
Joined: Apr 2012
Location: Mesa, AZ
Oddometer: 337
Originally Posted by
Gotta disagree here, too, and point you to:
Attitude/expectation matters a lot more than the type of bike. If you are willing and able to repair your $10k + bike after it falls down a cliff (as the folks in the previous thread did), then take it. If not, don't. If you aren't prepared and
expect you won't have to
, it's a problem if you DO have to.
Love the Heinlein quote though. I'm still working on the "Conn a Ship" part, and hope to not prove the Die Gallantly for a while yet ;)
I love that Mongolian ride report. It partially convinced me to buy a Tiger, despite the demonstration that the bike is dependent upon the speedo cluster being functional. Seems a bit bass-ackwards to me to put critical electronics in the speedo cluster rather than under the seat or somewhere else a little better protected.
But the Tiger did run on terrible Persian/Kazhak/Ickystan hillbilly gas for them, was resurrected twice I believe from what is near total destruction, and they had the fortitude to tough it out literally in outer Mongolia where some random dude welded their bike back together after waiting almost a month for Triumph UK to get them parts. That's tenacity and it's damned admirable.
Personally, I love my Tiger in the same way a lot of people in this subforum love their orange machines. But if it falls off a cliff (with me off it!) it is gonna be toast. All of its resale value will be gone. No reason to put thousands of dollars into OEM replacement parts, hundreds of dollars into questionable third world labor or tool purchase/rental and so on. I'd leave the bike in Mongolia and catch a bus/plane either home or to my destination. It's not worth the month sitting there pulling Tony-Stark-in-a-cave repairs, when I could be at home making money towards a new bike.
Which is why I lean towards cheaper disposable bikes for third world exploration. A 15 year old XR that has a piston failure? Maybe if someone has a replacement right there, sure... rebuild it. Falls off a cliff? Buy a new clunker bike from some guy in Colombia and finish the ride.
I think you and I are in agreement, though... you balance your investment (type and value of bike) with your ability to support it (dealership network, credit card limit, mechanical knowledge). In 10 years, I might be willing to take my Tiger to South America. Right now, it'd be my '93 XR600 though.
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SUNSET HARBOR—Harriet Benton greets everybody at the Sunset Harbor senior nutrition site by name, flashing a bright smile and asking if they are having a good day.
The site, in the fellowship hall of Faith Community Chapel on Sunset Harbor Road, is open every day from 10 a.m.-2 p.m., and offers more than a meal to local seniors looking for socialization.
Residents at Cardinal Pointe Apartments in Shallotte had their first alligator sighting of the season this past weekend, when an alligator was spotted swimming in a retention pond behind several apartment buildings.
The alligator was then seen sunbathing on Monday and swimming on Tuesday. N.C. Wildlife Enforcement officer Matt Criscoe said for now, the alligator is going to be left in the pond.
The Brunswick Community College Fitness and Aquatics Center is now open.
The center opened last week and had its grand opening Saturday, offering tours of the building. There was also a drawing for free memberships. Staff members were on hand to show visitors all the amenities the 55,000-square-foot building has to offer.
A 9,000-square-foot gymnasium with an NCAA-regulated floor and seating for 1,500 spectators will serve as the new home of BCC's basketball and volleyball teams. While practices and games are not going on, the gym is open to all members.
SHALLOTTE—Aldermen are mulling possible road improvements and additions to help solve downtown traffic problems and meet requirements of the town's vision plan.
On Tuesday, the town heard possible alternatives from traffic engineers from Ramey Kemp, the firm the board hired to help with road and traffic issues.
Engineers presented several "Main Street alternatives" including widening Main Street to a five-lane section, which would be the least expensive option but would also be the least pedestrian friendly and have the lowest vehicle capacity.
Transportation Secretary Eugene Conti has awarded contracts for nine highway and bridge projects using $36.3 million of North Carolina's $6.1 billion federal stimulus share.
Among the shovel-ready project contracts awarded March 23 by Conti in the first wave of stimulus-funded road projects was the Smith Avenue extension project in Shallotte.
Conti, whom Gov. Bev Perdue appointed Transportation Secretary Jan. 5, awarded a $6.3 million contract to S.T. Wooten Corp. of Wilson for the Smith Avenue extension project in Shallotte.
SHALLOTTE—Two suspects were arrested after a sheriff's deputy witnessed an alleged drug transaction between the two suspects in Walmart's parking lot last week.
According to Brunswick County Sheriff's Office Drug Enforcement Agent Joe Cherry, both suspects fled when confronted by the deputy.
Brian Ray Mobley, 44, of 2875 Paddlewheel Trail, Supply and Orrey Palmer Clemmons, 44, of 1040 Hewett Road, Supply, were both arrested Tuesday, March 24, and taken to the Brunswick County Detention Center.
RALEIGH—A second pair of bills taking aim at The Beach Plan has been introduced in the state House and Senate.
Rep. Bonner Stiller, R-Brunswick, co-sponsored House Bill 742 to prohibit beach plan surplus distribution, which was introduced in the House March 24. Sen. Tony Rand, D-Cumberland, introduced a similar bill in the state Senate.
Both bills require the Beach Plan, or the N.C. Underwriting Association, to retain any accumulated surplus within the association.
ASH—A Columbus County woman was killed last week in a wreck that left one man seriously injured.
According to N.C. State Highway Patrol Sgt. C.C. Albritton, Jennifer Nicole Porter, 20, of Tabor City, was driving her 2001 Chevrolet passenger vehicle north on Ash-Little River Road around 5:25 p.m. Thursday, March 19.
Porter attempted to turn left onto N.C. 904, failing to yield to an oncoming vehicle, Albritton said.
The Brunswick County Sheriff's Office has teamed up with the Governor's Highway Safety Program to bring a series of driving simulators and demonstrations to Brunswick County.
The event, slated for 10 a.m.-4 p.m. Saturday, April 4, at the Leland Walmart, will feature the Governor's Highway Safety Program's 18-wheeler with three driving simulators that feature multiple driving scenarios.
To stress the importance of wearing seat belts, there will also be a crash simulator, which will put participants through a controlled 5 mph-impact.
BOLIVIA—Child protective services workers at the Brunswick County Department of Social Services want the community to know their goal is not taking children away from their parents.
In fact, they're mainly focused on giving parents the resources they need to solve whatever problems are putting their children in harm's way. Gerri Barnes and Tiffany Irving say they make sure they empathize with the parents and work with them to solve their problems.
Copyright © 2015
The Brunswick Beacon is your source for local news, sports, events and information in Brunswick County, North Carolina and surrounding areas.


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A device which can be implanted in the body and comprises an electrically conducting support covered with a layer of electrically conducting polymer, to which layer is attached at least one biologically active substance of an anionic or cationic nature. The deposition of the polymer is carried out, in a first stage, by electropolymerization directly directly on the support or, according to an alternative form, by deposition of the polymer in solution on the support. In a second stage, electrochemical oxidation or reduction is conducted and the biologically active substance with an anionic or cationic nature is attached to the polymer.
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1. Field of the Invention
The present invention relates to an implant covered with a polymer capable of releasing various substances and, more particularly, to a stent covered with a polymer capable of encapsulating biologically active substances which are intended for the treatment of restenosis and of releasing them locally, and to a process for depositing a polymer on a support.
2. Description of the Related Art
Techniques have been developed in various medical fields which consist in introducing implants or prostheses into the human or animal body in order to correct or limit certain deficiencies.
Thus, in the field of cardiology, the technique of balloon angioplasty of arterial stenoses is widely used today in the treatment of coronary or peripheral vascular lesions responsible for angina pectoris, myocardial infarction and arteritis of the lower limbs. This technique consists in introducing, under angiographic control, a probe with an expandable balloon into the vessel to be treated at the contracted region and in reestablishing the blood flow by crushing the atheromatous plaque in the wall of the vessel. It is thus generally possible to avoid recourse to conventional surgical techniques in achieving arterial or peripheral revascularization.
However, angioplasty exhibits the disadvantage of often resulting in a further contraction of the artery, known as restenosis. In approximately 30 to 40% of cases, this restenosis occurs in a period of six months and cannot be predicted. It is essentially due to retractile healing of the artery and to proliferation of the smooth muscle cells of the arterial wall, in response to the attack produced by the introduction of the balloon. These two phenomena result in a further contraction of the arterial lumen.
The administration of medicaments, such as angiotensin converting enzyme inhibitors, anti-inflammatories, platelet anti-aggregants, anti-coagulants and the like, has not made it possible to effectively combat the phenomenon of restenosis.
Use is made, in preventing arterial retraction, of metallic endovascular prostheses in the form of a small spring, known as stents, which are inserted into the artery after having carried out the dilatation. The stent has the effect of impeding the immediate elastic return of the wall of the artery and, in the longer term, of preventing the constriction of the artery. On the other hand, the presence of the stent does not have a favorable effect on the proliferation of the smooth muscle cells and, in some cases, it can even aggravate it.
It is therefore desirable to be able to combine an effective medicinal treatment with the insertion of the stent.
It is known that some antisense oligonucleotides exert an in vitro and in vivo antiproliferative activity (M. R. Bennett et al., "Inhibition of vascular muscle cell accumulation in vitro and in vivo by c-myc antisense oligonucleotides", J. Clin. Invest. (1994), 93, 820-28). However, no effective technique for the administration of such compounds has been described. Antisense nucleotide derivatives adsorbed or encapsulated in poly(alkyl cyanoacrylate) nanoparticles are disclosed in Patent FR-A-2,724,935, which provides this technique for their intratumoral administration in the treatment of certain cancers.
Patent DE-A-4,429,380 discloses a process for the preparation of stents with a ceramic or metallic support which are coated with an intermediate layer of amorphous silicon and with a layer of semiconductive material, these two layers overlapping each other.
Metallic stents covered with a first composite layer of a polymer and of a therapeutically active substance coated with a second layer of fibrin are disclosed in Patent Application EP-A-701,802. The polymer used is chosen from silicones, polyurethanes, polyesters, polyethers and vinyl derivatives. Furthermore, according to Patent EP-A-566,245, fibrin can be used in the treatment of restenosis. Tests carried out on pig coronary arteries with various biodegradable polymers (for example, polyglycolic acid/polylactic acid, polycaprolactone, and the like) or non-biodegradable polymers (polyurethane, silicone, poly(ethylene terephthalate)) have revealed significant inflammatory reactions accompanied by fibrocellular proliferation of the arterial wall (W. J. Van der Giessen et al., Circulation, (1996), 94, 1690-97).
Thus, there currently exists no system effectively combining, in the treatment of restenosis, a stent and a substance having an antiproliferative effect on smooth muscle cells.
A subject-matter of the present invention is therefore a device which can be implanted in the body, or endoprosthesis, and in particular a stent, covered with a polymer capable of encapsulating biologically active substances with an anionic or cationic nature and of releasing them locally, which can be used in the treatment of various conditions and in particular of endoprosthetic thrombosis and of restenosis in the field of coronary angioplasty and of peripheral arterial angioplasty.
The invention also relates to a process which makes it possible to deposit an electrically conducting polymer, comprising a biologically active substance, on an electrically conducting support, such as a metallic support and in particular a stent.
The process in accordance with the present invention makes possible the electrochemical deposition of an electrically conducting polymer, for example a polymer derived from pyrrole, naphthalene or thiophene, which can be obtained in aqueous medium under mild conditions, that is to say at room temperature and under moderate saline conditions, from commercially available monomers. Furthermore, the electrochemical deposition makes possible precise control of the thickness of the polymer layer deposited on the support and the medium used does not comprise a chemical oxidizing agent or an organic solvent which might have harmful effects in the application envisaged. In the case where the electrochemical polymerization is difficult or cannot be envisaged, the polymer can be prepared in solution in an appropriate solvent, according to a conventional technique, and can be deposited on the support by spraying or dipping, followed by evaporation of the solvent.
The process of the invention comprises essentially two stages. In a first stage, an electropolymerization is carried out directly on the metallic support or, according to an alternative form, the polymer is prepared in solution and is deposited on the metallic support as indicated above. Then, in a second stage, an oxidation (if the polymer is cationic) or a reduction (if the polymer is anionic) is carried out and, simultaneously, the biologically active substance is attached to the polymer. The oxidation and the reduction, depending on the situation, are carried out electrochemically in a known way by creating a potential difference between the electrically conducting support and the polymer, in order to form respectively positive or negative charges which promote the attachment of the active substance. For example, the formation of a polymer matrix promotes the attachment of an active substance composed of a positively charged phosphorylated nucleic base; conversely, the formation of positive charges in the polymer promotes the attachment of an active substance composed, for example, of an oligonucleotide or a protein carrying negative sites, such as ATP, or more generally any negatively charged particle, such as heparin, a vector for plasmid genes or a linear or circular DNA fragment of plasmid type.
According to a preferred embodiment of the process of deposition of electrically conducting polymer in accordance with the invention, the electrochemical polymerization is carried out in the presence of a water-soluble polymer chosen from a polyethylene glycol, a polyvinylpyrrolidone, a polyethylene oxide, a copolymer of ethylene oxide and of propylene oxide of Poloxamer type, a polyethylene acetate, a poly(vinyl alcohol), a polyacrylamide and water-soluble polyurethane derivatives. The presence of such a water-soluble polymer in the polymer matrix makes it possible to improve the permeability of the polymer to anionic entities, such as oligonucleotides, used as active substance and facilitates the controlled release of these molecules on contact with solutions comprising competing ions originating, for example, from the addition of sodium chloride. Use is preferably made of an amount of polymer representing between 4 and 10% of the overall composition.
More particularly, the polymer film can advantageously be formed in two stages, the first consisting in polymerizing the monomer at a concentration of between 0.01 and 0.1 M approximately, in order to form a bonding layer with a thickness of less than approximately 1 μm, the second consisting in prolonging the polymerization reaction in the presence of water-soluble polymer, in order to obtain a layer with a thickness of greater than 1 μm which can be between 2 and 10 μm approximately.
It is therefore advantageous to use a metallic support made, for example, of steel, of metal alloy or of a metal which is biocompatible and more particularly of stainless steel, tantalum, platinum, gold, nickel-titanium alloy or platinum-indium alloy. A support made of stainless steel can be advantageously used when the electrolytic medium does not comprise chloride. It is also possible to use a nonmetallic support, such as biologically compatible electrically conducting charged polymer.
The oxidation is carried out, after deposition of the polymer as indicated above, by applying an oxidation potential to the support for a predetermined period of time. Thus, for example, depending on the polymer used, it is possible to apply a potential of approximately 0.3V to 1V with respect to a hydrogen reference electrode for a period of time of between 30 minutes and 3 hours approximately, depending upon the properties desired.
According to one characteristic of the invention, by virtue of the oxidation stage, it is possible to adjust the ability of the active substance, in particular oligonucleotides, to attach to the polymer and to subsequently control the release thereof locally on the site to be treated, once the stent has been positioned in the body. The charging of the active substance to the polymer is advantageously carried out simultaneously with the oxidation stage, the concentration of active substance in the oxidation solution being adjusted to an appropriate value which can be between, for example, 1 and 200 μM, depending on the substance used and the desired degree of attachment. It is thus possible to achieve a degree of attachment of greater than several nanomoles/mg of polymer, in combination with slow release kinetics, ensuring a prolonged effect of the active substance. This technique makes it possible to obtain, for example, release kinetics of the order of several picomoles of active substance per mg of support per day.
The release kinetics observed by using the technique of the invention are related to the thickness of the polymer film. It is possible, in accordance with the invention, to adjust the release kinetics of the active substance by choosing an appropriate thickness of the polymer on the support, for example of between 2 and 10 μm approximately.
The active substance is chosen according to the use envisaged for the implant. Thus, in the case of a stent covered with a polymer intended for the treatment of postangioplastic restenosis, the active substance is preferably an antisense oligonucleotide capable of selectively blocking the expression of the genes controlling the proliferation of smooth muscle cells of the arterial wall. Use may be made, for example, of oligonucleotides and more particularly of antisense oligodeoxyribonucleotides (ODN) with a phosphodiester or phosphorothioate structure, which are directed against the insulin-like growth factor receptor (or IGFR) as described by P. Delafontaine et al. ("Regulation of vascular smooth muscle cell Insuline-like Growth Factor I Receptors by phosphorothioate oligonucleotides", J. Biol. Chem., (1995) 270, 14383-388) and WO-A-96.10401, or oligodeoxynucleotides comprising n contiguous guanines, it being possible for n to vary from 2 to 5, as described by Burgess et al. ("The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a non-antisens mechanism", Proc. Nat. Acad. Sci. USA, (1995) 92, 4051-4055).
These oligodeoxyribonucleotides generally have a very short lifetime in the free state in the body because they are rapidly digested by nucleases, which limits their effectiveness. The present invention is therefore particularly advantageous because it makes it possible to protect these oligodeoxyribonucleotides in the polymer matrix and to deliver them gradually on the same site, where they can then act effectively.
Furthermore, in accordance with the invention, the oligonucleotide can be radioactively labeled. The radioactive isotope makes it possible to monitor the attachment to the polymer and can also result in an antiproliferative effect on smooth muscle cells. The labeling can be carried out conventionally, for example by means of 35S sulfur or of 32P phosphorus, the half-lives of which are 87 days and 15 days respectively and are suitable for the development over time of restenosis.
The polymer used for covering the stent, in accordance with the present invention, is chosen from electrically conducting polymers exhibiting satisfactory properties of biological tolerance. Use is preferably made of a polypyrrole, a poly(diaminonaphthalene) or a poly(3,4-ethylenedioxythiophene) or poly(EDT), which exhibit appropriate electrical conduction and mechanical strength properties without harming the mechanical qualities of the support used.
It can be advantageous, in accordance with the present invention, to apply, to the polymer carrying the oligonucleotide, a layer of substance, such as fibrin, known for its antithrombotic activity.
The invention applies very particularly to a stent covered with a polymer comprising an active substance which is effective in the treatment of restenosis. It can apply more generally to any implant capable of being covered with a layer of cationic (or cationizable) or anionic (or anionizable) polymer which can act as reservoir of active substance carrying positive or negative charges which is intended to be released locally, for example substances exhibiting pharmacological properties of use in the treatment of leukemias, solid tumors and organ rejections.
The examples below illustrate the invention in more detail without limiting the scope thereof.
The electropolymerization of 3,4-ethylenedioxythiophene is carried out by means of a conventional electrochemical cell comprising three electrodes: a platinum counterelectrode, a silver wire covered with silver chloride acting as reference electrode providing a constant potential, and a working electrode of platinum sprayed onto a glass plate with an area of 0.6 cm2, giving a potential with respect to the counterelectrode.
The vessel of the cell comprises the solution of monomer to be polymerized and the salt providing the electrical conduction.
The monomer is 3,4-ethylenedioxythiophene, to which a polyethylene glycol (3×10−2 M) or a polyvinylpyrrolidone (2×10−3 M) is added. The electrolytic solution is PBS (phosphate buffered saline) at pH 7.4 comprising the following salts: KCl (2.7 mM), NaCl (0.14 M), KH2PO4 (1.4 mM) and Na2HPO4 (6.4 mM).
The monomer is added to the PBS solution diluted 15 fold. The potentiodynamic method (cyclic voltametry) is used, the potential ranging from −0.1V to +1.3V with respect to Ag/AgCl for 10 to 30 cycles. Oxidation of the monomer begins at approximately 0.9V. The final cycle is halted at the higher potential in order to obtain a homogeneous oxidized film. The thickness of the film, measured by means of a scanning electron microscope, is 2.5 μm (10 cycles) or 5.4 μm (20 cycles). The thickness of the film can be increased by increasing the number of cycles. However, beyond approximately 30 cycles, there is a risk of the mechanical properties of the film deteriorating.
One of the oligonucleotides indicated below is subsequently incorporated as active substance by oxidizing the polymer at a potential of +0.7V with respect to an Ag/AgCl reference electrode in a PBS solution comprising an amount of oligonucleotide equal to 1 μM. The potential is maintained for approximately 1 h 30.
The polymer film charged with oligonucleotide is quickly rinsed with water on both faces of the working electrode.
The antisense oligodeoxyribonucleotides (ODN) successively used in this example are as follows:
5′-CTC-TCG-CAC-CCA-TCT-CTC-TCC-TTC-T (phosphorothioate)
IGFR TCC-GGA-GCC-AGA-CTT-CAT-TC (phosphorothioate)
C-Myc 5′-AAC-GTT-GAG-GGG-CAT (phosphodiester).
These ODN are purified by high performance liquid chromatography (HPLC) on a reversed-phase C18 column using tetraethylammonium acetate/acetonitrile elution buffers.
In order to monitor the encapsulation of the oligodeoxyribonucleotides (ODN) in the polymer film, radioactive labeling is carried out according to a conventional technique using 32P as isotopic label.
The labeling is carried out by transfer of a 32P radioactive phosphate group from ATP to the 5′ position of the ODN by polynucleotide kinase at 37° C. in acetate buffer medium.
The electropolymerization is carried out of a naphthalene derivative, 5amino-1,4-naphthoquinone (ANQ, concentration 10−2 M), in an acetonitrile solution comprising 10−1 M LiClO4. The potentiodynamic method (cyclic voltametry) is used, the potential being varied from 0.5V to 1.45V with respect to a calomel reference electrode (SCE) for 40 minutes.
The thickness of the film, measured by means of a scanning electron microscope, is 1 μm.
The positively charged active substance is subsequently incorporated by reducing the polymer at a potential of −0.3V with respect to an SCE in an aqueous solution with a pH of approximately 7 comprising the positively charged substance. The potential is maintained for approximately 20 minutes.
The procedure is as in Example 1,3,4-ethylenedioxythiophene being used as monomer but the polymer film being formed in two successive stages.
In a first stage, the monomer is polymerized in the same PBS medium as in Example 1 diluted 15 fold. The concentration of monomer is 3×10−2 M. The technique used is identical to that of Example 1 but with only two scanning cycles being carried out, so as to form a film with a thickness of approximately 0.5 μm constituting a bonding layer.
In a second stage, a polyvinylpyrrolidone with a molar mass of approximately 40,000 is added to the medium at a concentration of 2×10−3 M and the polymerization is prolonged until a poly(3,4-ethylenedioxythiophene) film exhibiting a thickness of approximately 6 μm is obtained.
The tests carried out using a platinum stent as support have demonstrated the excellent mechanical properties of the polymer coating, which has good adhesion.
The experiments carried out with the stents of the invention have demonstrated very good tolerance after implantation in vivo, allowing their use to be envisaged in the treatment of restenosis.
Thus, a platinum stent covered with polymer prepared as indicated in Example 1, which stent has a mesh structure, was implanted in the abdominal aorta of two New Zealand rabbits weighing 3.5 kg. An identical stent but not covered with polymer was implanted in the same animal, in the same aorta but 2 cm upstream, and acts as control stent. Treatment with aspirin was begun one day before the operation (0.07 mg/ml of drinking water) and then prolonged throughout the duration of the implantation. The two arteries were removed three and fifteen days after inserting the stent and examined by standard histology after fixing.
On the 3rd day, parietal thrombus is not observed. A moderate proliferation, not covering the meshes of the stent, of smooth muscle cells is recorded at the contact regions between the stent and the arterial wall. The presence of some circulating erythrocyte and polynuclear cells and of some collagen fibers is recorded. The appearance of the two stents, that is to say the control stent and the stent covered with polymer, is identical.
On the 15th day, no parietal thrombus is observed. The proliferation of the smooth muscle cells is somewhat more accentuated and is composed of the same components as above. The proliferative layer is more organized, covers the meshes of the stent covered with polymer and exhibits a layer of endothelial cells at the surface, thus promoting the stabilization of the process.
These tests confirm the properties of bio- and hemocompatibility of the poly(EDT) polymer used in accordance with the invention.
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MAC Cosmetics' Euristocrats II Collection
You can find official collection details posted earlier, but here are some higher res images for the upcoming collection, slated for July 2nd, 2009. Continue reading →
You can find official collection details posted earlier, but here are some higher res images for the upcoming collection, slated for July 2nd, 2009. Continue reading →
What shadows would you use? What would you use on cheeks? Anything added to the lips? Create a look using whatever you want, as long as you include today's look book product!
Did you come up with a look you'd like to share featuring today's product? You can link to your images, embed your images using HTML, or you can submit your images via e-mail to share them with readers to help give them inspiration on how to use the product!
Get inspired by the colors of yesteryear; dabble in shades of ANTIQUITY of muted beige, gold, and brown.
With an eyeshadow brush, apply a light, muted beige all over the lid. In the middle third of the lid, lightly pat on a mustard yellow shade with a fluffy brush. On the outer third of the lid, blend a deep antique gold shade with a fluffy eyeshadow brush. Using a tapered crease brush, lightly blend the antique gold color into the crease Define the crease with a small, tapered crease brush and tap a soft, reddish-brown shade to add depth. Highlight the brow bone with a soft neutral highlighter shade, and then line upper/lower lash line (as desired) with dark shade of chocolate brown. For complementing cheeks, try sunkissed cheeks by dusting a light touch of bronzer, flush of coral, dusting of gold, or bronzy-berry. Finish the look with lip colors in corals, reds, or raspberries for best results.
Check out some of our product recommendations by brand for getting this look!
This was a look I wore last weekend, super, duper simple. I normally wouldn't have even bothered with colored liner, but I really wanted to try out my Guerlain Lagun Bleu khol, since I haven't had a chance to yet.
What's your super duper simple look?
You will need the following…
Directions: Define brows using a coordinating powder shadow applied with the 266 brush. Apply Lagun Bleu on lower lash line, and then apply Guerlain Bleu Cerise mascara on lashes. Sweep apples of cheeks with Margin blush using the 129, then highlight with Dior Amber Diamond Skin Shimmer with the 188. Apply Sunsational lipstick to lips, and then top with Gold Rebel lipglass for color and shine.
Check out more photos! Continue reading →
The choice is yours… Truth, Dare or Both? Zoya Nail Polish lets you decide what fashion is right for you this fall. Will it be Truth or Dare? Should you? Would you? hmmmmmmmm…
To compliment the collections, six super glossy lip balms from Zoya Hot Lips are also available.
Availability: July 15, 2009. Each bottle retails for $6.00. www.zoya.com
See more photos! Continue reading →
What is your favorite color of eyeshadow to wear? Why?
I love greens! There's just something about greens that suits me from my skin tone to my eye color to my personality.


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Originally written on NESN.com | Last updated 9/5/12
ST. LOUIS, MO. - JANUARY 12: Rick Nash #61 of the Columbus Bluejackets waits for a face-off against the St. Louis Blues at the Scottrade Center on January 12, 2010 in St. Louis, Missouri. (Photo by Dilip Vishwanat/Getty Images)
The NHL and the NHL Players Association have broken off collective bargaining negotiations, with no new date to reconvene. In other words, another NHL lockout is just 10 days away. If this season does get back on track, though, there's plenty of news from the offseason that will make this a great season to watch. Check out these Top 5 NHL offseason transactions and hope fans get a chance to see these players perform on their new teams this year. 1. New York Rangers Acquire Rick Nash The New York Rangers failed to get Zach Parise in free agency, but...
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Originally written on Celtics Life | Last updated 7/24/13
When he's not busy giving away valuable possessions during the regular season with ill-advised decisions, Brandon Bass spends his summers giving away prizes and lessons to the boys and girls in Baton Rouge, LA. Since 2008, the Brandon Bass Reach Back Foundation has been hosting a series of basketball camps in the area. This year, the camps will take place during August 1-3 at various locations. The camps will not only focus on teaching kids the fundamentals of basketball but it will also help them gain a better respect for the game. T-shirts and a photo with Bass will be provided to the participants While space is limited, each camp is free and open to the public. The schedule is as follows: Thursday, August 1, 2013, 9:00 a.m.-12:00 p.m. Pointe Coupee Central High School 8434 Pointe Coupee Rd Morganza, LA 70759 Friday, August 2, 2013, 9:00 a.m.-12:00 p.m. Devall Middle School 11851 North River Road Port Allen, LA 70767 Saturday, August 3, 2013, 9:00 a.m.-12:00...
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On phone, no link. But Gammons has "reported" on it and that he has heard he tested positive. But he has said that he doesn't believe it...yet.
Also, as a side note, Cano and Melky are BFF.
On phone, no link. But Gammons has "reported" on it and that he has heard he tested positive. But he has said that he doesn't believe it...yet.
Also, as a side note, Cano and Melky are BFF.
Last edited by edabbs44; 09-20-2012 at 04:47 PM.
Uh oh!
"Strickland Propane... Taste the meat, not the heat." - Hank Hill
Multiple outlets on Twitter debunking this rumor. Looks like there's nothing to it.
unfortunately it doesn't surprise me anymore when anyone gets busted for PEDs.
For every action there is an equal and opposite criticism.
"No matter how good you are, you're going to lose one-third of your games. No matter how bad you are you're going to win one-third of your games. It's the other third that makes the difference." ~Tommy Lasorda
Figures a Red Sox outlet would run this story without any kind of confirmation.
Be another big suspension if it's true, no doubt.
If evolution is outlawed, only outlaws will evolve!
"Reality tells us there are no guarantees. Except that some day Jon Lester will be on that list of 100-game winners." - Peter Gammons
These aren't the Roids you're looking for
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Turning the Right Corner to Low-Carbon Transport
Shifting to low-emission transport modesTurning the Right Corner analyzes what countries need to do to transition to a low-carbon transport sector and how they can pay for it. The transition will involve... Show More +
'Maximizing Mobile' Highlights Development Potential of Mobile Communications
A mobile revolutionThis new report, the third in the World Bank's series on Information and Communication Technologies (ICTs) for Development, analyzes the growth and evolution of mobile telephony, and... Show More +
Changing Gears: Green Transport for Cities
Where are the opportunities for transformational impact?Developing countries still face a large transport infrastructure gap. However, there is more than one way to span this gap: low-emission public transport... Show More +
Resilience Dialogue: Preparing for a Changing World
Rapid urbanization and climate change are reshaping and exacerbating disaster risk. Together, they have added urgency to the task of building resilience in communities and countries around the world.Climate... Show More +
Sanctions Board to Post Decisions on Corruption, Fraud Cases
December 9, 2011 - More than a dozen firms vied for contracts on a World Bank-financed transportation project. But that bidding competition largely turned out to be a sham. A Bank investigation revealed... Show More +
Climate Change Portal Helps Visualize World Climate, Expand Access to Data
Adds World Bank Climate Change Envoy Andrew Steer: "This Climate Change Knowledge Portal enables ministers, development institutions, and non-governmental organizations in developing countries to... Show More +


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California braces as snow and rain pile up
SACRAMENTO, Calif. The second in a series of winter storms moved into California on Saturday, bringing strong winds, the threat of mudslides, heavy rain at lower elevations and feet of snow in the mountains.
The National Weather Service issued a winter storm watch through Sunday evening for western Plumas County and the west slope of the Sierra Nevada in the north and the mountains of Ventura and Los Angeles counties in the south.
"It looks like we'll be getting a lot of precipitation," said George Cline, a National Weather Service forecaster in Sacramento.
He expected the storm to bring an inch of rain to the Central Valley, with wind gusts up to 60 mph. Gusts up to 90 mph were expected on mountain ridges.
The California Department of Transportation was requiring chains for travel on all major highways over the Sierra. Chains were also required for Interstate 80 through most of Nevada.
Forecasters were warning of whiteout conditions, with snow expected to fall up to two inches an hour at the peak of the storm. They said the new snow would also bring extreme avalanche danger to the alpine backcountry.
The storm was expected to leave more than a foot of new snow at lower elevations and two feet in higher areas in the northern Sierra. Snow was expected as low as 5,000 feet.
The new snow was piling on top of powder left by two earlier storms in recent days, bringing smiles to skiers.
Boreal ski area atop Donner Summit was reporting 15 inches of new snow Saturday, before the new storm. Squaw Valley USA, just north of Lake Tahoe, reported up to 10 inches of new snow, while nearby Alpine Meadows reported up to 20 inches.
To the south, snow accumulations between 8 and 16 inches were expected by Sunday morning above 6,000 feet in the Southern California mountains. Sustained winds of 25 to 35 mph with gusts to 50 mph were expected.
The National Weather Service posted a flash flood watch for parts of Southern California as moderate-to-heavy showers and thunderstorms came ashore. Residents of Southern California foothill communities near the slopes scorched by fires were urged to be on guard for possible mud and debris flows.
Rain could fall at rates up to three-quarters of an inch per hour through early Sunday. Forecasters said that could bring a threat of flash floods and debris flows in areas that have been burned by wildfire. Major canyon roads through the burn areas remained closed.
The burned hills above a La Crescenta neighborhood let loose a thick layer of debris Saturday afternoon, leaving a residential road covered in dirt, rocks and roots. No damage to homes or injuries were reported.
Near the Hollywood Bowl in Los Angeles, a family decided to evacuate a home in a neighborhood where rain threatened to bring mud and debris down the hillside. A city building inspector put a yellow tag on the house, advising residents of potential structural problems.
Nearly 5,000 utility customers throughout Los Angeles were sporadically without electricity, mostly because of downed branches crashing onto power lines.


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Turkey Lime Mould
2 Aug 2010
|Lime flavored gelatin
|6 Ounce (2 Packages, 3 Ounces Each)
|Ginger ale
|7 Ounce, chilled (1 Bottle)
|Diced cooked turkey
|2 Cup (32 tbs)
|Dairy sour cream
|1 Cup (16 tbs)
|Ground ginger
|1⁄4 Teaspoon
|Canned pears
|16 Ounce, drained and diced
Dissolve gelatin and 1/4 teaspoon salt in 2 cups boiling water; cool.
To half the gelatin mixture, slowly add ginger ale and 1/2 CUP cold water.
Chill till partially set.
Fold in turkey.
Pour gelatin mixture into 6 1/2-cup mold; chill till almost firm.
Meanwhile, beat sour cream and ginger into remaining gelatin till smooth.
Chill till partially set.
Fold in pears.
Pour over almost firm layer.
Chill till firm.
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Turkey Lime Mould Recipe


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An oligo-based microarray offers novel transcriptomic approaches for the analysis of pathogen resistance and fruit quality traits in melon (Cucumis melo L.)
1 Molecular Genetics Department, Centre for Research in Agricultural Genomics CRAG (CSIC-IRTA-UAB), Barcelona (08034), Spain
2 IRTA, Plant Genetics Department Centre for Research in Agricultural Genomics CRAG (CSIC-IRTA-UAB), Cabrils (08348), Spain
3 Departamento de Biología del Estrés y Patología Vegetal, Centro de Edafología y Biología Aplicada del Segura (CEBAS)-CSIC, Apdo. correos 164, 30100 Espinardo (Murcia), Spain
4 Instituto de Conservación y Mejora de la Agrodiversidad Valenciana (COMAV-UPV), CPI, Ed.8E, Camino de Vera s/n, 46022 Valencia, Spain
5 Research Unit on Biomedical Informatics (GRIB), Experimental and Health Science Department (Universitat Pompeu Fabra) Barcelona (08080), Spain
BMC Genomics 2009, 10:467 doi:10.1186/1471-2164-10-467Published: 12 October 2009
Melon (Cucumis melo) is a horticultural specie of significant nutritional value, which belongs to the Cucurbitaceae family, whose economic importance is second only to the Solanaceae. Its small genome of approx. 450 Mb coupled to the high genetic diversity has prompted the development of genetic tools in the last decade. However, the unprecedented existence of a transcriptomic approaches in melon, highlight the importance of designing new tools for high-throughput analysis of gene expression.
We report the construction of an oligo-based microarray using a total of 17,510 unigenes derived from 33,418 high-quality melon ESTs. This chip is particularly enriched with genes that are expressed in fruit and during interaction with pathogens. Hybridizations for three independent experiments allowed the characterization of global gene expression profiles during fruit ripening, as well as in response to viral and fungal infections in plant cotyledons and roots, respectively. Microarray construction, statistical analyses and validation together with functional-enrichment analysis are presented in this study.
The platform validation and enrichment analyses shown in our study indicate that this oligo-based microarray is amenable for future genetic and functional genomic studies of a wide range of experimental conditions in melon.


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River Plate stumbles to scoreless draw at Tucuman
BUENOS AIRES, Argentina - BUENOS AIRES, Argentina (AP) - River Plate stuttered to a scoreless draw at bottom club Atletico Tucuman in the Argentine Clausura tournament on Sunday to increase the pressure on coach Leonardo Astrada.
Goals were also at a premium in the day's other matches. Defending champion Banfield lost ground at the top after a 0-0 draw at Velez Sarsfield, while Lanus also drew 0-0 with Rosario Central.
Independiente still leads the standings despite enduring a second defeat in a row with a 1-0 home loss to San Lorenzo on Saturday. Independiente will drop from first place if Godoy Cruz, Argentinos Juniors or Estudiantes win on Monday.
River coach Astrada will be lucky to hang on to his job after another disappointing result.
The point left River in 17th position in the 20-team league and facing increasing problems in the table of average points used to calculate the relegation positions.
If River doesn't improve soon, the club will be in danger of dropping out of Argentina's top flight next season.
Banfield failed to close the gap on Independiente despite Velez resting its first choice players ahead of a decisive Copa Libertadores fixture on Thursday.
Ruben Ramirez had the best chance for Banfield in the first half, but goalkeeper Marcelo Barovero smothered the danger, while Leandro Caruso saw his shot deflected wide for Velez shortly after.
Velez had Leandro Somoza sent off in the 86th minute.
The draw moved Banfield to 23 points. Independiente has 27, Godoy Cruz and Argentinos have 25, and Estudiantes has 24.
Mid-table Lanus also fielded a team packed with reserves ahead of the club's Copa Libertadores match on Wednesday, but still held struggling Rosario Central to a scoreless draw.
Boca Juniors - second from bottom of the league - face Arsenal on Monday with new coach Roberto Pompei in charge. Pompei took over after Abel Alves became the third Boca coach to resign in 10 months, stepping down following a 3-0 loss to Colon on Thursday.
The other fixtures on Monday are: Godoy Cruz vs. Tigre; Estudiantes vs. Racing Club; Boca Juniors vs. Arsenal; and Argentinos Juniors vs. Colon.
In Saturday results it was: Newell's Old Boys 3, Chacarita Juniors 0; Huracan 3, Gimnasia 1; Independiente 0, San Lorenzo 1.
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Behold Grace Jones and Bow Down, Please
MILAN, ITALY - SEPTEMBER 20: Grace Jones performs at the amfAR Milano 2014 - Gala Dinner and Auction as part of Milan Fashion Week Womenswear Spring/Summer 2015 on September 20, 2014 in Milan, Italy. »
MILAN, ITALY - SEPTEMBER 20: Grace Jones performs at the amfAR Milano 2014 - Gala Dinner and Auction as part of Milan Fashion Week Womenswear Spring/Summer 2015 on September 20, 2014 in Milan, Italy. »
New York Fashion Week is upon us; it's off to an auspicious start with BCBG Max Azria's eye-catching, geometric fall/winter line. »
London-based brand Ralph & Russo showed its first couture line in Paris this morning — the first time a British house was invited to show on the official couture calendar since 1915! — and its inaugural couture season, fittingly, hearkened back to Haute Couture's heyday. »
Maison Martin Margiela is a house enamored with the idea of reappropriation; for this couture season, though, the in-house team has replaced the usual found items (i.e., baseball mitts, candy wrappers painstakingly embroidered onto silk) with vintage fabric sourced from private estates. »
Stéphane Rolland's spring 2014 couture show was, as WWD puts it, the site of a stampede — Kim Kardashian was in the front row, and photographers flocked to her in a state of mild frenzy. But the real star at the event (no offense, Kim) was the collection itself — Rolland said that each piece was meant to "challenge… »
For this season's Chanel haute couture collection, Karl Lagerfeld drew his inspiration from the unlikeliest of sources. How unlikely are we talking? Well, um, every model on the runway was wearing formal sneakers. Some were wearing couture knee pads. »
Tuesday witnessed Saudi Arabia's first fashion show. The fashions at the women-only show followed a moderate Islamic dress code; no photography or videotape was allowed. [Global Voices] »
For those who can't get enough of model dodgem, I took a trip through the YouTube to dredge up only the most interesting variety of catwalk pratfalls and near-misses. »
Milan Fashion week kicked off over the weekend and one thing is for sure: the Italians are getting sentimental over the Summer of Love. Roberto Cavalli put his favorite animal prints on tights, which were then paired with everything from long and flowing boho dresses to Mia Farrow-esque smocks. Missoni also played… »


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Originally written on Waiting For Next Year | Last updated 5/1/13
The Cleveland Indians have officially recalled starting pitcher Trevor Bauer from Triple-A Columbus. He will start on Wednesday night against former Indians ace Cliff Lee and the Philadelphia Phillies. Bauer is making his second start for the Indians after making his debut on April 6 against the Tampa Bay Rays. In said start, Bauer lasted five innings, allowing just two hits but walked seven. He also had an at-bat following an injury sustained by catcher Lou Marson. During his time in Triple-A, Bauer has made three starts, going 1-0 with an ERA of 2.50. He's thrown 15 innings, allowing just five earned runs to go with 24 strikeouts and just six walks. Would-be hitters have been held to a .242 average. To make room for Bauer on the 25-man roster, the Tribe optioned left-handed reliever Nick Hagadone. Hagadone has appeared in eight games with the Indians, recording an ERA of 2.45 without a decision. [Related:Indians 14, Phillies 2: Seven Home Runs…I Repeat…Seven Home Runs Pace Tribe]
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YIELD: Serves 6
Preheat oven to 425° F.
Trim and peel celery root and cut into 1-inch pieces. In a large roasting pan toss celery root with oil and salt and roast in middle of oven 30 minutes. Stir celery root and reduce temperature to 375° F. Transfer pan to lower third of oven if cooking loin. Roast celery root, stirring after 30 minutes, 1 hour more.


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Smart grid regulation: Why we should switch to performance-based regulation
Editor's note: Paul Alvarez is a consultant with deep experience evaluating smart grid performance. As you'll read, he claims that smart grid investments are different than any other investments a utility makes. As a result, they require new cost recovery approaches. I think this is perhaps the single most important issue facing our industry, so I asked him to share his opinions. Please use the Quick Poll and/or comment form at the bottom of the page to agree or disagree. -- Jesse Berst
Do we need a new cost recovery model?
If smart grid investments really are different, do they demand a different cost recovery model? One based on performance rather than investment? One that provides performance rewards as well as shareholder risk? Regulators in both Oklahoma and Ohio have approved performance-based smart grid cost recovery approaches. If my interpretation of these commissions' orders is correct, IOUs forfeit some or all of their returns if anticipated O&M savings are not achieved. At the same time, they get the opportunity for returns above the authorized rate if actual O&M savings are higher than anticipated. There are many other potential performance metrics that could be considered, including distribution line losses, demand response per customer, and, of course, reliability.
Capital investment does not (by itself) make a grid smart. The value comes from the manner in which utilities make use of smart grid data and capabilities. Therefore, performance-based cost recovery would better motivate IOUs to pursue the difficult and critical organizational, operational and regulatory changes required to maximize smart grid value than the traditional capital investment incentive approach. Granted, performance-based cost recovery can be difficult to execute. Even so, an open, non-litigious dialogue between IOUs and regulators that tackles this issue would be a strong step in the right direction from customers' perspectives.
Paul Alvarez is President of the Wired Group, a distribution business consultancy with a focus on smart grid benefit quantification and performance measurement. He has led teams that have completed comprehensive, independent evaluations of smart grid deployments for Xcel Energy (SmartGridCity) and the Ohio PUC (Duke Energy's Ohio deployment). For smart grid reference work, case studies, links to benefit and performance measurement resources and more, visit www.wiredgroup.net.
More on smart grid regulation...
How the traditional regulatory process can inhibit grid modernization (and why change needs to be on the table)
Ratemaking landmark: Illinois approves new way to set electric rates


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The backstory: About 3 weeks ago at 29 weeks pregnant I had intense pain in my stomach along with vomiting and diaharrea. After convincing the on-call OB that this was an extremely abnormal amount of pain (not just a gut-wrenching feeling from having the flu like he thought), I went to the hospital and was eventually diagnosed with a bad gallbladder full of stones. I was there about 2 days, the stone passed, and I went home and seemed fine. I'd say my pain was at a 9 during the worst parts. Since then I have been eating healthy and avoiding greasy/fatty foods like the plague. I'm the 3rd generation on my mom's side to have a bad gallbladder so you can definitely say it runs heavily in the family.
Then about a week ago, on Tuesday, I started having minor pain in my stomach again like the very beginning of the previous gallbladder attack. The pain level has not changed much in all that time and it's still going on. I guess on a 1-10 scale, I'd rate it at a 3 most times...kind of like having a really wicked headache that simply continues on for a week with no end in sight.
More recently: Now, since Thursday, whenever I eat for the first time in a day, within 2 minutes, the pain spikes to more like a 5 or 6. It goes away within a half hour to an hour, and it doesn't matter what I eat, but the pain is a little less intense if I down something liquid like a nutrition shake. My abdominal muscles clench an awful lot, and I can't tell if it's due to BH contractions or gallbladder issues. It's always really sore. If it's BH, then it's mostly only affecting my upper uterus. I have told my doctor about all this (except the upper uterus part) and she gave me a RX for Percocet to use on those pain spikes as Vicodin does nothing for me. However, she said that this exhausts what she can do for me regarding my gallbladder. If it gets worse or these pills don't help, I have to go to the hospital.
The question(s): Does anyone have any experience with a really bad gallbladder and late pregnancy? Or more importantly, did you have any attacks that lasted this long? Or had pain during eating? Did anything help you at all? Any vitamins or suppliments? Were you able to make it to the end of the pregnancy in this kind of pain all the time?
My doctors don't want to operate until DS is born and I agree with that choice all the way, but I want the surgery ASAP after he's out! Sorry this is so long, any help would be so appreciated!!!


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Add these to your next summer party or lazy afternoon on the deck—you can scoop without stress, thanks to Hungry Girl Lisa Lillien's...
11 Easy Skillet Dinner Recipes to Try
As the weather warms up, and you start craving something lighter, whip up this vegetarian pasta salad of chickpeas, radishes, snow peas, cherry tomatoes, and feta cheese. "Fill your container tightly so that it doesn't shift around during transit, and add plenty of color with cut vegetables," says Itoh.
Get the recipe.
Leave PBJ to the kids, and make yourself a traditional Vietnamese bahn mi. Assemble shredded vegetable pickle salad, radish pickles, and barbecued pork separately from a small baguette in order to avoid biting into a soggy mess come lunchtime. Don't have hours to simmer pork belly? Use sliced ham or canned tuna salad instead.
Get the recipe.
12 Delicious Halloween Cocktails


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If you only watch one show on TV, make it The Newsroom on HBO Sunday nights at 10. This tight, funny, mesmerizing drama, based on the high-wire act of producing a live daily national news show, is truly one of the best TV shows ever produced. Aaron Sorkin creates and writes the majority of the episodes, and it's brilliant.
The show is based on the network ACN, based in the fictional city of Atlantis, reminiscent of CNN's home base in Atlanta, Georgia.
The characters are all smart, neurotic types, who have an excess of book sense and not quite enough street sense to get by. Of particular note is Jeff Daniels, who plays the anchorman. This actor certainly has remarkable range. Mr. Daniels was such a convincing fool in the movie Dumb and Dumber, now he is the exact opposite: a highly intelligent but smug and neurotic news anchor. Other actors worth mentioning: the beautiful and talented Olivia Munn plays a financial reporter perfectly; and even the legendary Jane Fonda has a small role as a network executive.
You might say after watching a few episodes, well, people don't talk like that, with whip smart, velvety dialogue, but oh, if only they would!
I'd also like to mention the free service you get if you're an HBO subscriber. They now have a free service called HBO GO, which you can sign up for. It allows you to watch their programming on ROKU, iPads, your smart phone, Apple TV, Android, and other devices anytime you wish. Fun!
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Officials: Big beets for Billings
September 19, 2014 in Uncategorized
HARDIN, Mont. â Western Sugar Cooperative is going to have a big crop this year, and the biggest part of it will be in the Billings, Mont., production area.
âWe have a very respectable crop coming across Western Sugar,â said J. Kent Wimmer, lo…continue reading on thedickinsonpress.com


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Sorry i mean cIOS and IOS60 files, i cannot load them as it says in the tut. I keep getting the 1029 error....
Hi All
Can I just verify...If I have star patch 4.0 installed, then I am brick protected from firmware updates be it from game disk or online update?
ok guys I really need some help. I cannot get any version of WAD manager to install the IOS or CIOS files. I keep getting the ticket errors.
However I have managed to update the v4.0(wanikokos) without installing these IOS cIOS files.....am i doing any harm??? any ideas on how I can get the files to load correctly???
please help if possible!!
I accidentally missed installing the patched ios60 but have used waninkoko's updater and updated to 4.0
Now when I try to installed the patched IOS60 I get the following:
"Installing ticket... ERROR! (ret # -2011)"
What does this mean? I am getting it when trying to install other WADs now too. I have around 2000 blocks of free space on my wii.
Hi all. I followed the guide, and upgrading my 3.2E softmodded (From 3.4E) to 4.0E, hopefully everything still works after worths and also my Wii Shop. I just hope there comes an better hack soon, or else I'll have to get an mod chip in lol.
omg omg omg, I'm on 4.0E, still with all my channels and 100% working shop! Thank you SO much for this guide!
And If I want to install softmii?
And If I want to install softmii?
And what about my pirate virtual console games?
First off thanks for great tutorials!
I had a Wii with 3.3 on it. Followed tutorial and got upped to sm 4.0, Homebrew channel, all cIOS and IOS wads and patches installed no problem, including IOS60. I am successfully able to boot backups using the Backup Launcher v0.3, no issues! I am having some other bugs however.
1. I CANNOT for the life of me get VC or Wiiware .wads to be seen, let alone installed. I access HBC, load WadManager v1.3 using my SD card, and the only .wads the program will install are IOS's. It doesn't even give me the option of non-IOS wads (like VC or wiiware). I see people saying to install VC and Wiiware using HBC and running Wadmanager 1.3 all the time, what am I doing wrong? I'd love to run these games off of my 4gb SD card, but anything at this point would be great!
2. Gamecube backup loader v2 will not install on my Wii. Going through HBC to install, it sees the .dol file, but when I go to start/load it, an error message comes up saying that it's not a valid Wii file/program and exits.
3. I've looked around a bit, is there any way for DVDx or MPlayerx to successfully install on 4.0 to run DVD or Xvid files?
Thanks in advance! I've been out of Wii-modding for about a year now, so I claim some ignorance on softmodding, everything I always did was hardware modding.


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Amazon.co.uk's Best of 2009 in Books (Editors' Top 10 Picks - Business, Finance & Law) - #1
Amazon.ca's Best of 2009 (Top 100 Customer Favourites) - #26
Hudson Booksellers Best Books of 2009 (Best Business Interest) - Selection
Hudson Booksellers Best Books of 2009 (Bookseller Favourites) - Selection
About the Book
New York Times bestselling authors Steven D. Levitt and Stephen J. Dubner return with more iconoclastic insight and observations in this long-awaited follow-up to their blockbuster Freakonomics.
In 2005, Freakonomics exploded in the culture, forever changing our understanding of how the world works, how we really make decisions—even how we name our children. This revolutionary book spent two years on the New York Times bestseller list, sold more than 3 million hardcover copies, single-handedly spawned a new genre of books, and led to a column in the New York Times Magazine and a blog on the New York Times website. Now, University of Chicago economist Steven D. Levitt and award-winning writer Stephen J. Dubner return with this all-new book that is bigger, more provocative, and sure to challenge the way we think all over again.
• Freakonomics was one of the bestselling books of all time, selling more than three million copies and dominating the New York Times list for two straight years.
• SuperFreakonomics is based on all-new, revolutionary research and original studies by Steven Levitt. This provocative material has never been seen before.
• The authors' New York Times blog, www.freakonomics.com, is one of the Top 10 blogs in the world, according to TIME Magazine.
• Freakonomics was a New York Times Book Review Notable Book, a Globe and Mail bestseller, a Book Sense Book of the year, a Quill Award winner for the Best Business Book and a finalist for the Financial Times/Goldman Sachs Business Book of the year.
Educator and Librarian Resources
Product Details
- Imprint: HarperCollins Publishers Ltd
- On Sale: 10/19/2009
- Pages: 320
- List Price: 36.99 CAD
- BISAC1: BUSINESS & ECONOMICS / General


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Shawn Corbally
- Filed Under
The Marion County Sheriff's Department has begun its internal investigation into how it handled Shawn Corbally, who was let out of jail days before police say he brutally raped a woman in Greenwood.
An Aug. 5 Indianapolis Star investigation found that Corbally was still in custody -- on a sexual assault charge that was set to be dropped -- when a sheriff's deputy interviewed his mother, who confirmed he had lived with her for a month in Indianapolis despite being registered as a sex offender in Clinton County.
Doing so would be a felony violation of state sex offender laws. But five hours after ...


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3 day event includes cruise, 100' drag event, autocross and car show. Spectators in the thousands, hundreds of vehicle entrants. Very large, busy and fun weekend. All makes and models included. ...more >>
The 22nd annual Rocket Round Up in Olds will be held on July 18, 2015 at Hildebrand Motors in Olds, Alberta 12 noon - 4 pm. Use Google Maps to see where Olds is. Banquet to follow for those that wish to partake. Pre-registration for banquet required by July 11. Open to all Oldsmobiles 1897-2004. Numbered historic mini Olds artwork with easel to the first 75 participants. Free lunch to all. Music/Trophies/Club T-shirts/Club Golf shirts/Olds Pins/Olds items/flags. Door prize Lets Make a Deal. Long Distance Award club member only Long Distance Award non-club member only Mayor's Choice Award open to all Oldest Oldsmobile at Olds Award open to all 50/50 engine endurance contest Banquet afterwards at the Royal Canadian Legion. Register and pay on line www.oldsclub.ca Open to non-club members too, as long as you drive an Oldsmobile. Caravans leaving Edmonton, Calgary, Vancouver & Seattle. Olds is 60 miles north of Calgary on Hwy 2 QEII. Do it yourself car wash high pressure wandright around the corner from the show. Hotels and motels close by. Set up 9-12 / Show 12-4 Last year every participant won a door prize. This year you pick - door prize or envelope. You will pick your own door prize from the table. You can keep it or trade it for one of 38 envelopes. There is a total of $500 in the envelopes. 1 envelope: $100 / 2 envelopes have $50 each / 5 envelopes have $20 each / 10 envelopes have $10 each and 20 envelopes have $5 each. Will you trade? Videos of the 2010 and 2014 shows can be seen at... www.oldsclub.ca Rocket Roundup page Alternative site: www.oldsnorthernlights.com Pictures of shows from 2002 2014 at www.oldsclub.ca - Rocket Round up page. Questions?: [ email ] ...more >>


text: This family owned for more than 40 years business is addressed to the tourist that is fed-up with all inclusive "hundred star" Mexican resorts. The tourist that wants to know about Mexican tradition, culture, way of living. If you are that type of tourist, check-in here, and you will be more than welcomed. You might even fall in-love with the... More


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Masked is a room-escape game infused with a dark, mysterious and ambiguous story. What is the cracked, crumbling room in which you find yourself? Who is the woman behind the mask? What is your history? And how, if at all, can you escape?
Masked - a short-form point-and-click adventure game of the room-escape ilk - is now available as a free download.


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this wiki
Welcome to Memory Alpha!
Memory Alpha is a collaborative project to create the most definitive, accurate, and accessible encyclopedia and reference for everything related to Star Trek. The English-language Memory Alpha started in November 2003, and currently consists of 38,562 articles. If this is your first visit, please read an introduction to Memory Alpha.
Latest news
- 6 July 2015
- Idris Elba has confirmed he is filming Star Trek Beyond. [1]
- 4 July 2015
- A touring exhibit called Star Trek: The Starfleet Academy Experience will commence in Ottawa, Canada, on 26 May 2016. [2]
- 2 July 2015
- Adam Nimoy's Kickstarter for his documentary on his father has surpassed its fundraising target, with fans pledging $662,640. [3]
Featured article
"The Thaw" was the twenty third episode of the second season of Star Trek: Voyager.
As Voyager approaches a deserted planet, Lt. Tuvok notes that there are nonfunctional communication satellites in orbit. Evidence suggests an advanced culture with warp drive and similar technologies, but Kim announces that evidence indicates a major solar flare occurred nineteen years previously. There are no life signs and it appears that the atmospheric disturbances would have prevented any escape attempts. Janeway grimly realizes that the entire colony of 400,000 people was likely wiped out, however, Kim announces that they are being hailed from the planet's surface.Janeway tells Paris to play the message. A man named Viorsa appears and introduces himself as the planner of the Kohl settlement. He explains that Voyager's sensors have activated the message and that the Kohl have gone into a state of artificial hibernation in order to survive the effects of the ecological disaster on their world. The computer will awaken them in fifteen years, and he asks that no one interrupt their timetable. Chakotay points out that the colonists' timetable ended four years ago...
Memory Alpha portals
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Picture of the Day
| Bridge of the Andorian battle cruiser Kumari in 2153.
(ENT: "Proving Ground")
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The Star Trek trademarks, logos, and related names are owned by CBS Studios Inc., and are used under "fair use" guidelines.
The user-created content of this site is released under the Creative Commmons "Attribution-NonCommercial" license version 2.5, which can be found here. See Memory Alpha: Copyrights for more information.


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Shumway, Illinois
|United States
|39°11′3″N 88°39′11″W / 39.18417°N 88.65306°WCoordinates: 39°11′3″N 88°39′11″W / 39.18417°N 88.65306°W
|0.33 sq mi (1 km2)
|- land
|0.33 sq mi (1 km2)
|- water
|0.00 sq mi (0 km2)
|696.1 / sq mi (269 / km2)
|- summer (DST)
|Postal code
|Area code
|Wikimedia Commons: Shumway, Illinois
Shumway is a village in Effingham County, Illinois, United States. As of the 2000 census, the village population was 217.
Shumway is located at 39°11′3″N 88°39′11″W / 39.18417°N 88.65306°W (39.184144, -88.652977).[1]
According to the 2010 census, the village has a total area of 0.33 square miles (0.85 km2), all land.[2]
Shumway is also very close to Effingham, Illinois. Effingham is inching closer and closer to the Shumway city limits as Effingham expands subdivisions around the Lake Sara area.
Shumway is in the Beecher City/Shumway School District., although in earlier years, rural Shumway residents in Summit Township have filed petitions to leave the district. Older residents of this area still hold allegiances to Effingham High School. The reason for this "allegiance" was because when Shumway High School closed, many students east and south of Shumway went to Effingham schools. When districts were drawn many residents felt Beecher City gerrymandered Shumway into the district. Today, many kids around Lake Sara and east Shumway attend Beecher City, although Effingham Community schools are much closer.
According to Census 2010, Shumway has a current population of 202 residents. This is a loss of 15 residents. In 2000 Shumway has a population of 217 residents.
As of the census[3] of 2000, there were 217 people, 82 households, and 56 families residing in the village. The population density was 696.1 people per square mile (270.3/km²). There were 97 housing units at an average density of 311.2 per square mile (120.8/km²). The racial makeup of the village was 100.00% White.
There were 82 households out of which 40.2% had children under the age of 18 living with them, 47.6% were married couples living together, 17.1% had a female householder with no husband present, and 30.5% were non-families. 25.6% of all households were made up of individuals and 11.0% had someone living alone who was 65 years of age or older. The average household size was 2.65 and the average family size was 3.18.
In the village the population was spread out with 28.1% under the age of 18, 12.9% from 18 to 24, 28.6% from 25 to 44, 19.4% from 45 to 64, and 11.1% who were 65 years of age or older. The median age was 31 years. For every 100 females there were 102.8 males. For every 100 females age 18 and over, there were 100.0 males.
The median income for a household in the village was $43,125, and the median income for a family was $45,417. Males had a median income of $27,159 versus $18,750 for females. The per capita income for the village was $16,032. About 5.8% of families and 8.0% of the population were below the poverty line, including 8.0% of those under the age of eighteen and 15.4% of those sixty five or over.
- ^ "US Gazetteer files: 2010, 2000, and 1990". United States Census Bureau. 2011-02-12. Retrieved 2011-04-23.
- ^ "2010 Census U.S. Gazetteer Files for Places – Illinois". United States Census. Retrieved 2012-10-13.
- ^ "American FactFinder". United States Census Bureau. Retrieved 2008-01-31.


text: The NBA playoffs are just around the corner. Are you ready? If not, we've got a trip down memory lane that will get you in the postseason mood. The last 20 years have brought us a number of lasting Pacers' postseason memories. Sure they're Reggie-heavy, but he wasn't alone in helping the Pacers be among the Eastern Conference's powers.


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Chocolate Frosting
|Powdered sugar
|1 1⁄2 Cup (24 tbs)
|3 Tablespoon
|Cocoa powder
|2 Tablespoon (unsweetened)
|1 Tablespoon
|1⁄2 Teaspoon
1. To sift the powdered sugar, place the strainer over a sheet of waxed paper. Put the powdered sugar in the strainer. Use the large spoon to stir the sugar so it falls through the strainer. Measure 1 1/2 cups of sifted sugar. Save until Step 3.
2. Put margarine in the saucepan. Put the saucepan on burner. Turn burner to low. Heat till margarine melts. Turn off burner. Remove pan. Pour melted margarine into the bowl.
3. Add the cocoa powder. Stir with the wooden spoon till well mixed. Add about half of the powdered sugar, and all the milk and vanilla. Stir gently till mixed (mixture will be lumpy). Then, beat with wooden spoon till mixture is smooth.
4. Slowly add the rest of the powdered sugar, beating well. Beat in more milk, if needed, to make the frosting soft enough to spread. Use it to frost Choice Chocolate Cake.


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BLWEAP_1.10Dec 20, 2009 Full Version 2 comments
- Fixed underwater TNT pickup - Added spark from explosions - Fixed size of tesla-bones - Added animation of burning at HUD - Added new projectiles of...
Now there was a possibility to play in Duke Nukem 3D with weapons from Blood game! Addon replaces all Duke3D weapons and adds 2 more new weapons (RemoteTNT and Proximity mine). Also HUD it is changed on Blood HUD and new sounds from Blood are added.
No news has been posted here. If you have relevant news to share you should post it now.
- Fixed underwater TNT pickup - Added spark from explosions - Fixed size of tesla-bones - Added animation of burning at HUD - Added new projectiles of...
Changes: - changes animation of an akimbo shotgun altfire - alt-napalm projectile approached to the original Blood - player haven't hurt when respawned...
My little mod for eDuke32 which changes all original weapons to blood weapons. I call my mod BLWEAP and I make it for test weapons which will be includes...
Are you about bright pixels?
Anything new on this? o.0
Nothing :(
Overlords are still immune to flames from the alt-fire effects of the Flare Pistol, Spray Can, Napalm Cannon burning and fire pits.
Ok, after running through the 4th episode the changes you made are really good. I did see some things that could be tweaked to mirror the weapons of blood:
1. The Flare Pistol has the correct amount flares on the alt-fire now, now the problem is that the flares are splitting too late, reducing the time to split by maybe 30-35% should be about right.
2. The Tesla Cannon no longer blinds you! Hurray! But you forgot to fix the alt-fire, it still takes too long to fire.
3. The Napalm Cannon looks better now, the only thing wrong I am noticing is that the alt-fire napalm balls are picking random direction to bounce as opposed to bouncing forward and THEN picking a random direction to bounce after hitting an object.
4. The Spray Can I completely forgot to mention before is that the flames are a little too close to the face when they go off, if you can do what you did for the Tesla Cannon that should make it perfect.
5. The Life Leech and it's alt-fire are fixed! There is a slight problem woth the alt-fire though, I think it has trouble targeting monsters in the LOS that are at a different height than it, a monster would be standing next to it on a staircase and it won't fire at it unless it is at equal height.
More to come...
About time! DL now! ^^
blood hud aswell?
Yeah, it is
holy **** this looks good now
Promote Blood Weapon Mod on your homepage or blog by selecting a button and using the embed code provided (more).


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The library will be closed on Saturday, July 4th, for Independence Day.
Celebrate Lunar New Year with Goofball the Magician
A magician? For Lunar New Year? Yes! Goofball will both entertain and inform us with a show that incorporates magic from the East. Just look at his big smile and his costume. The children will laugh before he even starts his magic.


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Hotels in Israel
The wide range of Israel hotels includes plenty of luxury brands, guest houses, B&Bs (called zimmers), "hospices" (which are actually small hotels, geared to Christian pilgrims) and kibbutz hotels (popular with big groups). Over the years, most lodging options have not been known for their character or flair, but there are exceptions, among the best hotels in Israel:
The King David Hotel. It's not for the budget-minded, but this member of The Leading Hotels of the World may be the best, or at least one of the best, hotels in Israel. Dating back to British colonial times, the plush hotel boasts views of the Old City, a lush pool area and great service. It's also part of the small Dan hotel chain, which has more economical options in other parts of Jerusalem and Haifa.
The InterContinental David. This Tel Aviv hotel has reasonable rates but plenty of luxury perks (like personal sitting rooms) and is located on the beachfront promenade, with the beach, shopping, and restaurants an easy walk away.
Dan Eilat Hotel. This mid-range resort in Eilat, by the Red Sea, sits on a private beach with views of both sparkling blue water and mountains.
A shorefront hotel built in the late 1950's, recently renovated to preserve its original Modernist design. The property has 280 rooms and a popular new dining room, D Restaurant.
Israel found the perfect complement to its new architectural icons (the Santiago Calatrava–designed Jerusalem bridge; Ron Arad's Design Museum, in Holon) in the angular, elegant Mamilla Hotel by Moshe Safdie.
1930's property with a location a stone's throw from the Old City and rich interiors (redone by Adam Tihany in 2011) that are steeped in glamour: a long list of heads of state and celebrities have graced its halls.
Houses in a Bauhaus-style building that was one of the first movie theaters in the city, this film-themed property now has 82 rooms, complimentary Wi-Fi, and bikes for guests' use.
Opened in 2010, the hotel features black marble showers in the suites, leather couches in the library, and views of the Mediterranean.
Guests enter the terra-cotta-paved lobby to the smells of jasmine and honeysuckle. The resort stands near a tiny artists' colony in Galilee, a peaceful area on good terms with both its Jewish residents and Arab neighbors.
Housed in a Bauhaus building from 1937, the Gordon Hotel & Lounge is a bold architectural statement on Tel Aviv's waterfront. Israeli design firm Studio B6 kept the original whitewashed façade—the better to appreciate the views of the sea.
Stocked with custom wood furnishings and bold, Art Deco–inspired textiles, the five suites at this stylish property fit right into the city's artsy Neve Tzedek neighborhood.
The 55-room Savoy Hotel is a stone's throw from Tel Aviv's famous white-sand strands, as well as the city's bustling markets, cafés, and nightclubs. A recent renovation added 10 rooms (seven with Jacuzzi baths), balconies, and hardwood floors.
Rooms have minimalist, design-forward décor at this hotel in the heart of the city.


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Found the plug-in layer-info.py, at http://registry.gimp.org/node/26317, interesting.
To make it more useful, now it can generate some information beside viewing.
The additions are:
1) viewing and adding text explanations (date, etc...), about the layer, in a layer parasite
2) plug-in auto quit if no layer or initial image
3) permitting internationalization in 'user' folders (more text)
4) only one launch at a time
5) save the info for all layers and parasites in a text file.
Works like the blender brush size controls, making it easy to change your brush size with a mouse or graphics tablet by letting you drag the mouse left to right to interactively change the brush size.
Now you don't have to tap hotkeys repeatedly or interrupt your painting flow by moving the mouse to the slider
Gimp 2.8
Windows (tested on Windows 7 x64)
Linux (tested on Ubuntu 12.04 x64)
Another thin arrow GIMP Python plug-in called 'ArrowsCreator'.
It's characteristics are:
-produces many different types of straight arrows
-produces one type of 'path' arrow
-facilitates combination of multiple arrows
-interactive with GIMP
-developed on GIMP 2.6 (work on 2.8 except no repeat gradient in shaft and GIMP don't control brush size).
ATTENTION: don't change layer during execution of the plug-in. Also on my computer begin to get sluggish for certain type of arrow in image greater than 7 Mpx.


text:
Originally written on NFL Trade Rumors | Last updated 3/10/13
Chris Brown of BuffaloBills.com believes Bills FS Jairus Byrd could be seeking a similar contract to that of Chargers S Eric Weddle. Weddle signed a five-year deal worth $40 million back in 2011. The Falcons recently locked up S William Moore to a five-year contract worth $30 million that included $14 million guaranteed. Byrd, 26, is two years younger and doesn't have the same injury concerns as Moore, which should translate into more money for Byrd. As of now, Byrd will make a guaranteed $6.9 million salary for the upcoming season after the Bills franchised him last week. Buffalo will have until July 15 to negotiate a long-term deal, but Brown notes that contract talks "are not on the front burner right now." The post Jairus Byrd Could Be Targeting As Much As $40M In His Next Contract appeared first on NFL Trade Rumors -.
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