text:
High Places
Cultural Geographies of Mountains and Ice
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moreHigh places - be they mountain peaks or the vast expanses of the polar latitudes - have always captured the human imagination. Inaccessible, extreme, these sublime landscapes of rock and ice are commonly invested with awe and reverence, as places of physical challenge, intense experience, danger and death. Increasingly today, they are also treated as uniquely valuable locations for science and as barometers of environmental vulnerability. High Places is an exploration of the complex and fascinating geographies of these special environments._x000D_ _x000D_ The diverse aspects of these high places are explored, revealing how senses are challenged and distorted, objectivities exposed, cultural and political assumptions laid bare. Whether walking the summit of Pico de Orizaba, the fourth highest volcano in the northern hemisphere; recounting the tale of the American explorer Charles Wilkes, charged with 'immoral mapping' for reporting Antarctic land where none was later found; exploring the 200,000 year old Greenland ice core; or documenting encounters between native and traditional understandings and modern scientific discourse, the international contributors reveal the richness and significance of these unique locations. _x000D_ _x000D_ With a geographical range that spans Europe, Asia, North and Central America, Antarctica and the Arctic regions, High Places will engage all those with an interest in human and physical geography, history of science, polar and mountain studies, landscape, culture and environment. less
I.B.Tauris; October 2008
288 pages; ISBN 9780857713223
Read online, or download in secure PDF format
Title: High Places
Author: Denis E. Cosgrove; Veronica Della Dora
288 pages; ISBN 9780857713223
Read online, or download in secure PDF format
Title: High Places
Author: Denis E. Cosgrove; Veronica Della Dora
Buy, download and read High Places (eBook) by Denis E. Cosgrove; Veronica Della Dora today!
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34 year old man | Lansdowne, MD, USA | Seeking women 23-42 within 30 miles of Halethorpe, MD
Let's get to kow each other. I'm not a member so i can't read your emails. If you're interested in getting to know me read about me section.
Everything happens for a reason Hi, I'm not great at talking about myself but here it goes.... I'm an easy going, good hearted, loyal guy. Family and friends are very important to me and a big part of my life. I love to laugh and make others laugh. I think I'm pretty funny with a sarcastic sense of humor. If you like what you see you can reach me at bighopp @ m sn. I go with the flow and can have a good time doing just about anything. I get along with most people. I'm past the hard partying days but I still enjoy going out for a few drinks. I'm a huge Ravens and Orioles fan! I love going to games or watching at home. I enjoy traveling( especially road trips), Hitting golf balls, going to the shooting range, watching movies either at a theater or snuggled on the sofa, I just started fishing last year and really enjoy it. I love going out to eat and trying new foods. I also love to cook. I'm pretty good at it too. I have 3 tattoos and my tongue pierced. My DVR is always recording something. Some shows i watch are Modern Family, The Walking Dead, Parks and Rec, True Blood, East Bound and Down and New girl among others. I like most kinds of music. Most of the time I just let my ipod shuffle and it'll go from Sublime to Lil Wayne to metallica to Slipknot to Bob Marley. My favorites are rap and rock though. I'm looking for a down to earth, happy, loyal woman with a good sense of humor to have a serious relationship with. I try not to take things too fast. I feel you need to be friends before you can be more. Having said that I do have a tendency to fall pretty fast. If you like what you see contact me.
Cooking , Dining out , Fishing/Hunting , Hobbies and crafts , Movies/Videos , Music and concerts , Exploring new areas , Playing cards , Video games , Watching sports
Bowling, Walking / Hiking
I exercise 1-2 times per week.
I like Cats, Dogs
Middle of the Road
Vegas baby. Ocean city, MD.
I like all kinds of music. Rap, rock/alternative and pop are my favorites. My dvr is always recording something. MY favorite shows are The Walking Dead, Shameless, True Blood, The Big Bang Theory and Modern Family. I love sushi, seafood, mexican food
I can have a good time doing just about anything. I love to take road trips. I'm a great cook. I just got into fishing and love it. Love to cuddle up and watch tv or movies.
I've been reading the Game of Thrones books
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'10" (177cms)
|3'0" (91cms) to 8'11" (271cms)
|Body type:
|Slender, Big and beautiful, About average, Curvy, Athletic and toned, Full-figured, Heavyset, A few extra pounds, Stocky
|Black, Blue, Brown, Grey, Green, Hazel
|Dark brown
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way, Occasionally, Yes, but trying to quit
|Social Drinker
|Never, Social Drinker, Regularly, Moderately
|Labor / Construction
|No preference
I work for Howard County Public School System.
|I'll tell you later
|No preference
|Never Married, Widow / Widower, Currently Separated, Divorced
|Have kids:
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|Definitely, Someday, Not sure, Probably not, No, No, but it's OK if my partner has kids
|White / Caucasian
|No preference
|I'll tell you later
|No preference
|High school
|No preference

subset: commoncrawl


text:
Sustainable Building
Floating bamboo pavilions in China pop up in 8 short weeks
These multi-functional pavilions look like a floating village in Songyang County in China. The cluster of open-plan structures was built in only eight weeks using locally sourced bamboo topped with
Foster + Partners picked to design an exciting new transport hub in Wales
Foster + Partners has won the competition to design Cardiff Interchange, the city's central bus station. The proposal is part of a larger regeneration scheme for the Central Square, also designed by the
Carbon-negative Ashmount Primary School produces enough energy to power the neighborhood
The Ashmount Primary School is located in North London's Crouch Hill Community Park, an ecologically rich landscape and community asset converted from a derelict piece of Metropolitan Open Land. The new
Solar-powered Out of the Valley cabin is a perfect off-grid retreat for two
The Out of the Valley model cabin is clad in a charred timber, created with the Japanese shou sugi ban technique, and topped with a black corrugated roof. The dark exterior helps the cabin blend in with
Green-roofed Ruckers Hill House gives curated views of nearby Melbourne
The Ruckers Hill House, designed by Gardiner Architects, is a glassy sustainable abode for a young family of five in Melbourne. The sprawling home was designed to give the family members different views
This quirky Spanish eco-house is hidden under a rolling hill
The Live Garden House is a green-roofed vaulted home built using traditional techniques in Zaragoza, Spain. Spanish designers Alberto Monreal and Elisa Durán of Arquitecturas Naturales S.C. created this
Modern Kenjo Cabin is a Solar-Powered Floating Room For a Family in Sweden
Limmared, Sweden-based prefab builder Kenjo offers up small prefab cabins designed for those needing more space than can be used as a guest house, relaxation space, office, studio or even a floating
Bromley Caldari Architects transform a crumbling 1960's A-Frame house into a sunlit seaside home
New York-based Bromley Caldari Architects transformed a derelict Fire Island home into a gorgeous pyramidal structure that offers panoramic views of the bay. The original 1960s building, with a leaky roof
Net-zero Happy Meadow Courtyard House is a perfectly passive residence in North Carolina
Happy Meadows Courtyard House is a modern, age-in-place, net zero passive house designed by Chapel Hill, NC, architect Arielle Condoret Schechter. Constructed primarily of 5500 psi concrete, the
Luca Curci envisions a living Vertical City powered by the sun
Italian design studio Luca Curci Architects unveiled their proposal for a floating vertical city for 2,500 inhabitants.
London shoe polish factory transformed into RIBA award-winning charity offices
The most distinctive feature of the social justice center's facade is the zigzagging roofline that sits like a crown atop the new building extension. Clad in diamond-shaped zinc tile cladding, the three
archimania's Conservation Hall is a sunken extension that preserves a historic governor's mansion
Memphis-based architecture firm archmania designed an extension to a historic governor's mansion in Nashville, Tennessee, and created an "unbuilding"-the architects created a sunken courtyard building
Ismaili Center in Toronto is topped with a stunning angular glass dome
Ismaili Center in Toronto, designed by Charles Correa Associates and Moriyama & Teshima Architects, provides the city's Islamic community with a new cultural center dominated by a beautiful angular
OAS1S "treescrapers" are modern skyscrapers inspired by trees
OAS1S™ INTRODUCES THE NUMBER 1 GREEN ARCHITECTURE OAS1S™ introduces its concept for the number 1 green architecture; the unique design of houses as trees and communities as forests. An innovative,
8 Sustainable British buildings from the 2015 RIBA awards
The Foundry by Architecture 00 Architecture 00 repurposed a former shoe-polish factory into the Foundry, an office facility that houses various charities in London. Built on a former brownfield in
Copenhagen's largest school will be powered by solar energy
Located on the water's edge, CIS Nordhavn is sandwiched between the public waterfront and Copenhagen's urban fabric. A promenade outside the school provides public access to the waterfront. To
Google brings in Heatherwick to design its London headquarters
The original one million square foot Google headquarters in Lonon, designed by London-based architects Allford Hall Monaghan Morris(AHMM), has reportedly been deemed too boring and British designer Thomas
Scandinavia's largest library is powered by the sun
Designed to meet the Danish 2015 energy classification, Dokk1 was completed for a budget of over €280 million. Schmidt Hammer Lassen won the bid for the project after placing first in a 2009 design
Live in Harmony with Nature in These Super Sexy Tree House Cabins
Although the tree houses are custom made to order, the company builds each project with eco-friendly principles. Cutting edge computer technology is first used to detail every building aspect, and then
Build a Gypsy Wagon in the Woods – All It Takes Is Ingenuity, Elbow Grease And (mostly) Recycled Components!
The first thing you notice about this gypsy wagon is the surrounding smell of cedar forest and the sound of crashing waves from the lake, which is just a stone's throw over the hill. In the winter,
Method launches impressive new line of affordable prefab homes
Manufacturer of sustainable prefab buildings, Method Homes, teamed up with consultancy Elemental Design to create a new series of modular cost-effective homes that come in six different floorplans. In
Foster + Partners unveils new winery for Château Margaux in Bordeaux
Foster + Partners just completed the first building of the Château Margaux winery in Bordeaux, which includes refurbished buildings, a large new vinery and Vinothèque and existing two-century old
HAO's repurposed Wood Shed mimics Taiwan's forest landscape
The building envelope's tree-like silhouettes were inspired by the cypress forests of Alishan National Park, a national gem and popular destination located in Taiwan's mountainous Chiayi County. HAO
These affordable bamboo houses were built for just $2,500 each
Atelier COLE, Building Trust International, and Habitat for Humanity Cambodia teamed up to design an affordable and eco-friendly housing scheme for families affected by HIV/AIDS. The innovative project
Paxton Gate founder launches RareField Design/Build office in San Francisco
Who is RareField? If you live in San Francisco and enjoy eating out, there's a good chance that you've visited one of their projects without even realizing it. Flour and Water, Central Kitchen, and Le
Auneau Cultural Center in France mimics local covered market
Set back from the street, the Auneau Cultural Center is clad in a high performance concrete skin and glazed glass curtains, together keeping energy use low while efficiently making the climate comfortable
Solar-powered hospital heals patients with sustainable design in New Zealand
Completed late last year, the three-story-tall and spacious Kathleen Kilgour Centre is estimated to provide local cancer-treatment options for approximately 600 patients. The 3,000-square-meter building
New FBI Florida Headquarters will be completely self-sustaining by 2030
"This building expresses the dignity, enterprise, vigor, and stability of the United States government, while the landscape connects to the native environment by restoring wetlands and vegetation
INFOGRAPHIC: The 5 coolest solar buildings on earth
With the ever increasing investment across the globe into solar power, there is an unspoken competition between the world's brightest organizations to develop the largest, most effective, and impressive
House of Hungarian Music's circular facade intertwines with existing trees to preserve the landscape
MenoMenoPiu Architects' innovative proposal for the House of Hungarian Music in Budapest preserves the existing environment with a flexible and unique circular design that encourages environmentalism
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- Fragile X-associated Disorders
- Treatment & Intervention
- Research
- Resources
- Advocacy
- Community
- Support the NFXF
Gloria Rogers Pavilion
Online Registration URL: firstgiving.com/fxmo
The registration fee -$25 includes a T-shirt and hotdog lunch.
Children under ten (with a registered adult) may register for free and includes a lunch. T-shirts may be purchased for $10. Individuals with FXS are welcome to register at no charge and may purchase a T-shirt for $10. You need to register by August 5 to ensure your correct T-shirt size.
Fragile X families and friends
Bounce House, Pony Rides, games, face painting, Bubble Bus, Raffle, Door Prizes
Questions / Contact Information
Sue and Jack Fishman


text:
Lindsay Wildlife Museum: Volunteer training class, "Introduction to Wildlife Rehabilitation"
By Gary Bogue
Wednesday, January 6th, 2010 at 6:06 am in Lindsay Wildlife Museum, Wildlife, Wildlife Rehabilitation.
Treating coyote that was caught in a trap
The Lindsay Wildlife Museum, 1931 First Ave., Walnut Creek, CA, is offering a training program for volunteers, "Introduction to Wildlife Rehabilitation," on Saturday, Jan. 16.
This is your last chance until next fall for training to become a wildlife hospital volunteer and help the thousands of injured and orphaned wild animals the museum receives and treats every year.This is a great opportunity for you to help wildlife in our area.
For more information or to register for the class, go to http://www.wildlife-museum.org/calendars/detailsCal.php?classID=1510 … or call 925-935-1978.
You can find out more about this wonderful museum and its many special programs at http://www.wildlife-museum.org/
[You can leave a response, or trackback from your own site.]


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The Pen & Ink Book: Materials and Techniques for Today's Artist
Watson-Guptill Publications, 1992 - Art - 175 pages
Spanning the traditional to the innovative, this definitive resource covers all the materials and techniques of drawing with ink. Every type of pen, brush, ink, and drawing surface is detailed, and every technique is demonstrated, including mixing ink with other mediums.
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21 pages matching ink flow in this book
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Review: The Pen & Ink Book: Materials and Techniques for Today's ArtistUser Review - Goodreads
This book runs the gamot of materials and techniques for using various pen and ink tools and graphic mark making. Read full review
Brush Techniques
White Ink on Toned Paper
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100 percent rag acrylic acrylic paint airbrush Arches artist ballpoint pen bristol board brush calligraphy cold-pressed colored inks compositional contour create curved dark deckles depth tension detail dip pen drawing paper Drawing Strategies edge elements fibers film fountain pen FW nonclogging waterproof Gillott gray hatching hot-pressed illustration board ink drawing ink flow ink sticks Koh-I-Noor Koh-I-Noor Rapidograph kolinsky sable layer light lightfast manufactured marks Martin's medium Metalpoint moldmade movement neutral pH Newton series nonwaterproof opaque painting pastel pencil penpoint pigment plane quill Rapidograph Rotring Rotring ArtistColor scratchboard shadow shapes sizes sketchbook smooth solid black space Speedball Staedtler stationery stippling Strathmore sumi ink surface technical pen technical pen 2x0 techniques texture tone transparent Twinrocker handmade vellum viewer visual wash watercolor block watercolor paper watercolor round waterproof drawing ink waterproof india ink waterproof inks white ink Winsor & Newton


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Poached Stuffed Chicken In Tomato Wine Sauce
|Yellow bell peppers
|1⁄2 , diced
|Green bell peppers
|1⁄2 , diced
|Red bell peppers
|1⁄2 , diced
|Feta cheese
|8 Ounce, crumbled
|Boneless chicken breasts
|2 Pound, pounded to 1/4 inch thickness
|Tomato wine sauce
|1⁄2 Cup (8 tbs)
|Olive oil
|1 Tablespoon
|1 , finely chopped (White End Only)
|1⁄4 Pound, chopped
|2 Medium, chopped
|All purpose flour
|1 1⁄2 Tablespoon
|White wine
|1⁄2 Cup (8 tbs)
In a medium bowl combine the peppers and cheese.
Place 2 to 3 tablespoons of the mixture in the center of each breast.
Reserve any remaining filling for the sauce.
Roll each breast up around the filling.
Place each breast at one end of a 5-inch-square piece of plastic wrap.
Roll the wrap tightly around the breast and twist at each end.
Repeat with the same size square of aluminum foil.
Bring a 3-quart pot of water to a boil.
Drop the foil-covered breasts into the water and boil them for 20 minutes at a moderate boil.
In a medium skillet heat the oil over medium heat and saute the leek, mushrooms, and tomatoes until tender, about 10 minutes.
Add the flour, mix thoroughly and cook for an additional 5 minutes.
Add the wine and remaining pepper-and-cheese mixture.
Simmer over low heat until ready to use.
Remove the breasts from the water.
Unwrap each carefully and slice into 1-inch thick diagonal pieces.
Place the slices on a platter and spoon the tomato-wine sauce over them just before serving.


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- Filed Under
The condition of a Granville teen who was injured this past weekend in a sledding incident was unavailable Monday.
Janet Gregory, 16, was transported by medical helicopter to Nationwide Children's Hospital after she crashed into a tree while sledding. The incident occurred Saturday evening at 785 Granville Road, behind St. Edward the Confessor Catholic Church.
The family has requested information about Gregory's condition not be released to the media.


text: Ballistic Publishing - Call for Entries GoneA personal painting done in Photoshop and Paint Tool SAI. Copyright (C) Milica Jevtic 2007 All Rights Reserved No unauthorised duplication or distribution without explicit permission from the copyright holder. Artist Name: Milica Jevtic Artist Country: RS Entered for: Website: http://www.milyknight.weebly.comSoftware used: Adobe - Photoshop - -Other (Please specify in image description) About us | Contact us | Privacy Policy Copyright © 2003 Ballistic Media Pty. Ltd.


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Roasted Orange And Bell Pepper Soup
|Navel orange
|1 Large
|Yellow bell pepper
|1 Large
|2 Teaspoon
|Chopped onion
|1⁄2 Cup (8 tbs)
|Shredded carrot
|1⁄3 Cup (5.33 tbs)
|All purpose flour
|1 1⁄2 Teaspoon
|Chicken broth
|1 Cup (16 tbs)
|1% milk
|1⁄2 Cup (8 tbs)
|1⁄8 Teaspoon
|Black pepper
|1⁄8 Teaspoon
|1⁄8 Teaspoon
1. Cut orange in half crosswise, and slice about 1/4 inch from bottom of each half so it will sit flat. Cut bell pepper in half lengthwise, and discard seeds and membranes. Place orange halves, cut side up, and pepper halves, skin side up, on a foil-lined baking sheet; flatten peppers with hand. Broil 15 minutes or until blackened.
2. Place pepper halves in a zip-top plastic bag; seal bag, and let stand 20 minutes. Peel pepper. Squeeze juice from orange over a bowl to equal 1/4 cup; discard orange. Place bell pepper halves and orange juice in a food processor or blender, and set aside.
3. Heat butter in a small saucepan over medium heat. Add onion and carrot; saute 12 minutes or until carrot is tender. Add onion mixture to food processor; process until smooth.
4. Place flour in a small saucepan. Gradually add broth and milk, stirring constantly with a whisk until blended. Bring to a boil over medium heat, stirring frequently. Add bell pepper mixture, salt, black pepper, and paprika; reduce heat, and simmer, uncovered, 10 minutes, stirring occasionally. Garnish with oranges slices, if desired.


text:
The Journal Sentinel business department follows developments in the local retail industry
Another stimulus check offer
Roundy's Supermarkets Inc. is jumping into the scramble for your stimulus check, offering a 10% bonus if you use it to buy a $300 gift card at a Pick 'n Save, Copps or Rainbow store. For example you would get a $330 gift card in exchange for a $300 stimulus check.
The cards will be sold in $300 increments, but you don't have to spend your entire check, if it is larger than $300. Chairman Bob also will throw in a free reusable shopping bag, and free Roundy's brand bread, milk and eggs.
There are a lot of offers like this, and I expect to see more in the next week or so. Sears and Kmart also will give you a 10% bonus on gift cards in exchange for a stimulus check.
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The CG dinucleotides are known to be deficient in the human genome, due to a high mutation rate from 5-methylated CG to TG and its complementary pair CA. Meanwhile, many cellular functions rely on these CG dinucleotides, such as gene expression controlled by cytosine methylation status. Thus, CG dinucleotides that provide essential functional substrates should be retained in genomes. How these two conflicting processes regarding the fate of CG dinucleotides - i.e., high mutation rate destroying CG dinucleotides, vs. functional processes that require their preservation remains an unsolved question.
By analyzing the mutation and frequency spectrum of newly derived alleles in the human genome, a tendency towards generating more CGs was observed, which was mainly contributed by an excess number of mutations from CA/TG to CG. Simultaneously, we found a fixation preference for CGs derived from TG/CA rather than CGs generated by other dinucleotides. These tendencies were observed both in intergenic and genic regions. An analysis of Integrated Extended Haplotype Homozygosity provided no evidence of selection for newly derived CGs.
Ancestral CG dinucleotides that were subsequently lost by mutation tend to be recreated in the human genome, as indicated by a biased mutation and fixation pattern favoring new CGs that derived from TG/CA.
DNA methylation is central to important biological processes, including X chromosome inactivation[1], genetic imprinting [2], gene-expression regulation [3-5], and the defense mechanisms against parasitic DNA and transposons [6,7]. DNA methylation also plays an important role in pathological processes such as cancer [8], is closely related with histone modification and RNA-associated silencing [9], and may be involved in genomic instability [10].
DNA methylation in mammals is carried out by three methyltransferases (DNMT1, DNMT3A, DNMT3B)[11] that target the cytosine in CG dinucleotides. A stochastic model for the maintenance of methylation during DNA replication has been proposed that allows accurate epigenetic inheritance[9,11]. However, CG dinucleotides also experience a high mutation rate from cytosine to thymine through the deamination of 5-methylcytosine and a less-than-perfect repair mechanism for resulting G/T mismatches [12-14], which calls into question the stability of methylation of CG dinucleotides as an important epigenetic marker.
In the human genome, the number of CG dinucleotides is ~25% of that expected given observed base frequencies, which is due to a high mutation rate from 5-methylated CG to TG and its complementary pair CA[15]. 15% of all CGs are clustered in so called "CpG islands", which are often located at the 5' end of genes and overlap with the promoter region, especially in housekeeping genes [16]. Their methylation status is highly associated with gene expression [3], but despite this apparent functional constraint, loss of CpG islands has been observed as a common event in mammalian genomes [15,17,18].
Moreover, multiple pathways exist that preserve CG dinucleotides in the genome, including a lack of methylation of CGs in CpG islands and a strong correction bias towards C/G following T/G mismatches [14,19,20]. Two enzymes (TDG and MBD4) have been found to selectively remove the thymine from a T:G mismatch in the context of CpG dinucleotides [21,22].
In our previous study [23], we observed a strong fixation bias in favor of derived C/G alleles at CG-related sites (dinucleotides that differ by one-step mutation from CG: CT, CA, CC, AG, TG, GG) compared with C/G alleles at CG-free sites (positions not preceded by C or followed by G). TG and CA, which are predominant at CG-related sites, were suspected to contribute this bias. Since a large fraction of TG/CA sites are originally derived from deamination of of methylated CGs [24], we hypothesize that recreating ancestral CGs may be the driving force behind this bias. Data released by the HapMap project and various genome projects afford us the opportunity to test this hypothesis.
By analyzing the mutation and frequency spectrum of different derived alleles, while taking the sequence context into account, a significant mutation and fixation preference towards transition-generated CGs (CG derived from CA or TG) was observed, while no such preference was observed for transversion-generated CGs (CG derived from CC, GG, CT, AG). This mutation and fixation preference enables the recreation of ancestral CG dinucleotides lost via hypermutation to CA/TG.
Data collection
Human SNP data were retrieved from dbSNP (ftp://ftp.ncbi.nih.gov/snp/ webcite, Build 124), and curated by the method described elsewhere[25]. Briefly, the following SNPs were selected: nonindel, biallelic, uniquely mapped to nonrepetitive sequences, validated, and with at least 100 nucleotides (nt) of flanking sequence available both upstream and downstream from the SNP.
Sequences and reads for multiple species were retrieved from the NCBI Nucleotide Databasehttp://www.ncbi.nih.gov/sites/entrez?db=nuccore webcite and Traces Databasehttp://www.ncbi.nih.gov/Traces webcite. Finally, the chimpanzee(Pan troglodytes, whole genome, 2.82G), gorilla(Gorilla, 9.54G, unassembled), orangutan (Pongo, 18.37G, unassembled), and Gibbon(Nomascus, 18.64G, unassembled) genome sequences were used as outgroups to infer the ancestral allele for the human SNP.
The allele frequencies at each SNP site were estimated from flat files downloaded from the International HapMap Project (http://hapmap.ncbi.nlm.nih.gov/downloads/frequencies/ webcite, Build 23). The derived-allele frequency (DAF) for each SNP was estimated in three populations (unrelated individuals only): Yoruba(YRI), Utah residents with ancestry from northern and western Europe(CEU), Japanese and Chinese(ASN); only those SNPs successfully genotyped in all chromosomes (120, 120, 180 respectively) were kept for further analysis.
Inferring ancestral states of the SNPs
Inferring ancestral states using parsimony may be unreliable if the mutation or substitution rate is high[26]. In mammalian genomes, CG dinucleotides have a very high mutation rate [27]; therefore, two methods were applied to ensure accurate inference of the ancestral state.
First, MegaBLAST was used to map the human SNPs and their flanking sequences(100 bp on each side) to the four outgroup sequences (chimpanzee, gorilla, orangutan, gibbon)[28]. We inferred the ancestral allele only when the chimpanzee, gorilla, orangutan and gibbon alleles were identical and matched one of the human SNP alleles. A PERL script was written to retrieve the human SNPs and their corresponding outgroup alleles from the MegaBLAST result.
Second, we also downloaded a dataset of 14.3 Mb of well curated human/chimpanzee/baboon DNA alignments (http://pbil.univ-lyon1.fr/datasets/MeunierDuret2004/data webcite)[29] and the corresponding human/rhesus sequences from http://genome.ucsc.edu webcite. Blast was used to construct new alignments, and the final alignment length was shortened to 9.4 Mb. Human SNPs that map to the aligned chimp/baboon/rhesus sequences were retrieved and the ancestral state inferred as described above. Given the branch lengths estimated by Steiper and Young [30] for the primate phylogeny, reliable inference of the ancestral state can be obtained using these three outgroups even at CG related positions (Additional file 1).
Additional file 1. Illustration of the reliability of the parsimony method to count the mutations at CpG related sites using three outgroups: chimpanzee/baboon/rhesus. The phylogeny of the four species used to infer mutations is shown in (a). Branch length indicates the rate of substitution per site at non-CpG positions. Substitution rates at CpG sites are 10 times higher than that at non-CpG sites, (b) scenario when the parsimony method is reliable, (c) scenario when the parsimony method is not reliable. Scenario (b) is 10 times more likely to be observed than scenario (c). Comparably, if chimpanzee, baboon, or rhesus is used as a single outgroup respectively, the probability ratio between (b) and (c) would be 2:1, 0.4:1, or 0.4:1.
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For CpG islands, a single outgroup (chimpanzee) was used to infer the mutation direction to maximize the sample size, and the frequency spectrum was then corrected by Hernadez et al.'s method (Additional file 2) [26].
Additional file 2. Derived-allele frequency estimation in CpG island regions.
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Identification of SNPs located in CpG islands
We identified 37,503 CpG islands in the human genome using the CGi130 program developed by Takai and Jones (http://cpgislands.usc.edu/ webcite)[31,32]. The following search criteria, considered stringent according to the authors, were used: i) GC content ≥ 55%, ii) ObsCG/ExpCG ≥ 0.65, and iii) length ≥ 500 bp.
Gene annotation
The gene annotation for each SNP in our study was retrieved from the ENSEMBL database (ftp://ftp.ensembl.org/pub/ webcite, version 45), and SNPs were classified as intergenic, intronic, coding, 5'UTR, 3'UTR, 5'upstream, or 3'downstream. Any SNP classified into more than one category was removed from the analysis. This left us with 915243 intergenic, 634809 intronic, 18333 coding, 2055 5'UTR, 11329 3'UTR, 38398 5'upstream and 40749 3'downstream SNPs.
Detection of positive selection
A Long-Rang Haplotype test was utilized to detect recent positive selection. Specifically, the Integrated Haplotype Score (iHS) was calculated for each SNP, as described elsewhere[33]. We used the suggested cut-off value, namely an extreme positive (iHS > 2) or negative (iHS < -2) iHS score (indicating a longer haplotype associated with the ancestral or the derived allele, respectively), as an indication of recent positive selection.
Recombination hotspots and coldspots
The locations of recombination hotspots and coldspots were obtained from a fine-scale genetic map estimated from patterns of genetic variation, which provides a kilobase-scale resolution of recombination rates [34,35].
Mutation and fixation bias towards recreating ancestral CGs
Following our previous observation of a strong fixation bias in favor of derived C/G alleles at CG-related sites[23], we re-examined the mutation and fixation pattern of CG dinucleotides on a genome-wide scale, while taking the sequence context into consideration. The CGs generated by a single mutation from other dinucleotides were classified into transition-generated CGs (Tsg, CG derived from CA/TG) and transversion-generated CGs (Tvg, CG derived from CC/CT/AG/GG). Correspondingly, the dinucleotides derived by mutations from CG are divided into transition-damaged CGs (Tsd, CA/TG derived from CG) and transversion-damaged CGs (Tvd, CC/CT/AG/GG derived from CG). For comparison, the same mutations located in other sequence contexts (not preceded by C or followed by G) were used as the control data for each of these mutation types. Analyses were also done separately for CpG islands and non-CpG islands, since they have very different mutation patterns and nucleotide composition.
In the non-CpG island region, the number of mutations in each annotation category varies substantially, ranging from 819 for transversion-damaged CGs to 19631 for transition-generated CGs for YRI population (Table 1; Additional file 3 for CEU and Additional file 4 for ASN). A total of 9293 mutations are from CG to other dinucleotides, among which 91% are to CA/TG, which is significantly larger than the fraction of transitions for the control data (62%, P < 2.2e-16, Fisher Exact test). There are 26391 mutations generating new CGs from other dinucleotides, of which 74% are transitions (derived from CA/TG), which is significantly larger than the fraction of transitions at control positions (64%, P < 2.2e-16, Fisher Exact test). Such a biased process, dominated by mutations between CGs and CAs/TGs, predicts an increase in CG dinucleotides in the non-CpG island region, and differs significantly from the trend demonstrated by the control data (67831:64859, P < 2.2e-16, Fisher Exact test).
Table 1. Number of SNPs and average derived-allele frequency (DAF) for different mutation types in different annotation categories
Additional file 3. Number of SNPs and derived-allele frequency for different mutation types in different annotation categories in CEU.
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Additional file 4. Number of SNPs and derived-allele frequency for different mutation types in different annotation categories in ASN.
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In the CpG island region, a different pattern was found: 559 CGs are generated by mutations from other dinucleotides while 881 CGs are destroyed by mutations; there is thus a trend toward decreasing the number of CGs. The trend is in accordance with that shown by the control data for CpG island regions (1003 Cs/Gs generated vs. 1748 Cs/Gs destroyed, P = 0.139, Fisher Exact test), but differs significantly from that in the non-CpG island region (26391 CGs generated vs. 9293 CGs destroyed, P < 2.2e-16, Fisher Exact test).
Derived-allele frequencies (DAF) are shown in Figure 1 for YRI (Additional file 5 for CEU, Additional file 6 for ASN). In the non-CpG island regions, when the derived allele was not preceded by C or followed by G, transition-generated CGs (Tsg) and transversion-generated CGs (Tvg) had a similar average DAF in the control data (0.328 vs. 0.325, P = 0.1019, Mann-Whitney U test), indicating no intrinsic DAF difference for these two types of mutations (A/T- > G/C and C/G/T/A- > G/C/G/C). However, the average DAF of transition-generated CGs (Tsg) was significantly greater than for the control data (0.349 vs. 0.328, P = 7.6e-12, Mann-Whitney U test), whereas transversion-generated CGs (Tvg) had a significantly lower average DAF than for the control data (0.325 vs. 0.306, P = 1.3e-8, Mann-Whitney U test). Overall, it suggests a higher probability of fixation for transition-generated CGs (Tsg) than for transversion-generated CGs (Tvg)(P < 2.2e-16, Mann-Whitney U test). Meanwhile, the average DAF of CGs destroyed by transitions (i.e., CAs/TGs derived from CGs) did not differ significantly from the control data (0.309 vs. 0.308, P = 0.65, Mann-Whitney U test), nor was the average DAF of CGs destroyed by transversions (i.e., CC/GG/CT/AG derived from CGs) significantly different from the control data (0.331 vs 0.314, P = 0.65, Mann-Whitney U test).
Figure 1. Derived-allele frequency for different mutation types in YRI. Left histogram is for non-CpG island regions, right histogram is for CpG island regions. Abbreviations are the same as in the text, with the prefix of C- denoting the corresponding control dataset.
Additional file 5. Derived-allele frequency for different mutation types in CEU.
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Additional file 6. Derived-allele frequency for different mutation types in ASN.
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For CpG islands, the DAF for YRI is shown in Figure 1, and in Additional file 5 for CEU and Additional file 6 for ASN. Transition-generated CGs (Tsg) had a much higher DAF than transversion-generated CGs (Tvg)(0.379 vs. 0.326 for YRI, P = 0.023, Mann-Whitney U test). However, the control data showed the same trend (0.355 vs. 0.313, P = 0.0058, Mann-Whitney U test).
To investigate the influence of potential errors in assigning ancestral alleles on the above analyses, 9.4 Mb multiple sequence alignments of human/chimpanzee/baboon/rhesus were created by another method and analyzed. The same mutation and fixation patterns were observed (Additional file 7, Additional file 8).
Additional file 7. Number of SNPs and derived-allele frequency for different mutation types in the 9.4 Mb non-genic region.
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Additional file 8. Derived-allele frequency estimated by different methods of inferring the mutation direction in the 9.4 Mb DNA alignment. Diamond symbol denotes the mean DAFs (± s.e.m).
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Selection on the CG dinucleotides?
To investigate if the above results might reflect selection on functional elements, the SNPs were classfied into four categories: intergenic non-CpG island; genic non-CpG island; intergenic CpG island; and genic CpG island (genic regions included the sites annotated as intronic, coding, 5'UTR, 3'UTR, 5'upstream, 3'downstream). Normally, intergenic, non-CpG island regions are regarded as neutral, so if selection is playing a role in the trends we observed, there should be differences between genic and intergenic patterns. However, we found similar patterns in genic and intergenic regions (Table 1).
We also applied the iHs test for signals of recent positive selection on newly-generated CG dinucleotides. Newly-generated CGs with iHs < -2 may be under positive selection while whose iHs > 2 may be under negative selection. Among 16843 transition-generated CGs, there were 322 (1.9%) with iHs < -2, which is not significantly different from the fraction of transition-generated Cs/Gs in the control data with iHs < -2 (2.1%, P = 0.1462, Fisher's Exact test). Similar results were obtained for transversion-generated CGs (Table 2). Overall, there is no evidence that newly-generated CGs are under recent positive selection.
Table 2. Recent selection on the newly generated CG dinucleotides in different mutation categories
With the phylogeny of ((((((CG,CA)CA)CA)CA)CG)CG) for ((((((human1,human2)chimpanzee)gorilla)orangutan)gibbon)rhesus)(phylogeny tree is shown in Additional file 9), phylogenetic analyses can reveal situations where an ancestral CG mutated to CA and then back to CG in the human lineage. A total of 34 SNPs were identified as back-mutations to CGs, of which three had a significant iHs value (Table 3), which is higher than the fraction of mutations with significant iHs values in the control data (P = 0.011, Chi-square test). All three significant iHs values involve transition-generated CGs rather than transversion-generated CGs.
Table 3. Recent selection on the backmutated CG dinucleotides
Additional file 9. Phylogenetic tree for reliable back-mutations from CA to CG.
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Fixation bias in the recombination hotspots and coldspots
BGC (Biased Gene Conversion) is a phenomenon universal in vertebrate genomes and results in fixation bias towards the C/G allele in the process of repair of double-strand breaks induced by recombination[36]. If the BGC effect is responsible for the fixation preference observed here (namely, transition-generated CGs are more prone to be fixed in the genome compared with the control data), then recombination hotspots and coldspots should differ. The result is shown in Figure 2 for YRI (Additional file 10 for CEU, Additional file 11 for ASN).
Figure 2. Derived-allele frequency for different mutation types in recombination hotspots and coldspots in YRI. Columns on the left of the solid line represent the pattern without the influence of the CG context (mutations not preceded by C or followed by G); columns on the right of the solid line represent the pattern with CG context.
Additional file 10. Derived-allele frequency for different mutation types in recombination hotspots and coldspots in CEU.
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Additional file 11. Derived-allele frequency for different mutation types in recombination hotspots and coldspots in ASN.
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In the recombination hotspots, C/G derived from T/A had a much higher DAF than T/A that derived from C/G (0.347 vs. 0.304, P < 2.2e-16, Mann-Whitney U Test), which is in accordance with BGC effect. Meanwhile, the DAF was significantly greater for CG derived from CA/TG than for the control data (0.365 vs. 0.348, P < 2.2e-16, Mann-Whitney U Test), whereas the DAF of TG/CA derived from CG didn't differ significantly from the control data (0.296 vs. 0.304, P = 0.546, Mann-Whitney U Test). In the recombination coldspots, T/A derived from C/G had the same average DAF as that of C/G derived from T/A (0.316 vs. 0.320, P = 0.989, Mann-Whitney U Test), indicating that the fixation bias toward C/G disappeared in regions of low recombination, which is expected under BGC model. However, the DAF of CG derived from CA/TG is still higher than that of CA/TG derived from CG (0.343 vs. 0.290, P = 0.1717, Mann-Whitney U test), as well as that of the control data (0.343 vs. 0.320, P = 0.230, Mann-Whitney U test), but not statistically significant. Overall, these results indicate that the tendency observed in our study might be partially explained by recombination, further study is needed to address this question.
Mutation and fixation bias recreating ancestral CGs
The observation that CG dinucleotides are under-represented in vertebrate genomes has received much attention. Much evidence suggests that the observed deficiency of CG dinucleotides is caused by hypermutable methylated cytosine, which mainly exists as the CG dinucleotide in vertebrate genomes[24]. This is further supported by the observation that 90% of the mutations from CGs are transitions to CA/TG in our study, accompanied with the overrepresentation of TG/CA in the genome reported by others [24]. More directly, when the CGs in CpG islands become methylated, CGs mutate to TG/CA at a comparatively high rate [37]. It is estimated that the advent of heavily methylated genomes dates to approximately 450 million years ago, leading to a lower CG frequency [38,39]. Meanwhile, CpG islands which were thought to lack methylation were also being lost [15,17,18].
Yet the methylated CG dinucleotide acts as an essential substrate for many regulatory reactions [8]. This was believed to be a high fidelity process, until studies revealed the possibility of deleterious mutations induced by deamination of 5-methylcytosine [12-14]. The question then arose as to whether CG dinucleotides would vanish from the genome.
In our study, by analyzing the mutations involving CG dinucleotides in non-CpG island regions, a strong tendency toward increasing CG dinucleotides was observed, due to biased mutation and fixation patterns. Specifically, there are about three times as many mutations generating new CGs as mutations eliminating CGs, mainly due to the overwhelming number of mutations from CA/TG to CG. Furthermore, transition-generated CGs had a higher average DAF than transversion-generated CGs, and in comparison to control data, transition-generated CGs had a significantly higher DAF while transversion-generated CGs had a significantly lower DAF. Since most CA/TG dinucleotides are derived from deamination of 5-methylcytosine, many mutations from CA/TG to CG should be back-mutations after CG mutated to CA/TG. This scenario thereby recreates ancestral CGs in the genome while preventing novel CGs that derived from CC/CT/AG/GG.
By contrast, in CpG island regions, which are relatively abundant in CG dinucleotides, there seems to be a tendency toward reducing the number of CG dinucleotides. This may reflect evolution from a non-equilibrium GC content in such regions, as the equilibrium GC content in the human genome is estimated to be 33%-42%[29], which is much lower than the present GC content (> 55%).
Natural selection or neutral mechanism?
Although the preference for transition-generated CGs was observed both in intergenic and genic regions, it could be driven by natural selection as many regulatory elements are located in intergenic regions [40-43]. The assumption of the selection test we applied is that, if the higher average DAF was caused by positive selection on these transition-generated CGs, a larger proportion of the CGs should exhibit signals of positive selection, compared with the control dataset. However, no difference between the CG and control data was observed, indicating that newly-generated CGs were not excessively subject to recent positive selection (Table 2). The analysis of inferred back-mutations similarly indicated that such back-mutations also were not significantly influenced by recent positive selection.
It should be noted that the failure to detect the signal of recent positive selection could also have other explanations. The present methods for detecting the signal of recent positive selection are mainly targeted at a region rather than a specific locus [33,44], and identifying causal variants is quite challenging. Since positive signals may come from hitchhiking with the selected allele, applying such methods to isolated sites rather than a genomic region may lack sufficient power. Moreover, weak selection would be difficult to detect as well. Therefore, these results do not rule out some role for selection in producing the patterns observed in this study.
Extension of BGC model?
As an alternative to selection, the BGC model is a neutral process that increases the probability of fixation of mutations that increase GC content in the human genome [20,45]. It is therefore of interest to investigate if our findings can be explained via an extension of the BGC model in the context of CG dinucleotides, in particular the fixation preference for recreating ancestral CGs, or if some other mechanism must be invoked.
Recombination was reported to be the cause of BGC [29,46] and this is supported in our study, as the fixation preference for C/G rather than A/T exists in recombination hotspots, but not in the recombination coldspots. The fixation preference for transition-generated CGs we observed in our study might be partially driven by the recombination, as there were no significant difference between recombination hotspots and coldspots. However, more evidence is needed to address this question, as we have a rather small sample size in this analysis.
In this study, we identified a trend that could be responsible for generating new CG dinucleotides in non-CpG islands, which are otherwise deficient in the human genome; namely, an excess number of mutations from CA/TG to CG, which in turn recreates ancestral CG dinucleotides in the human genome that had been previously lost by mutation. It appears that neutral process, which might be partly associated with recombination, is responsible for this trend. By contrast, in CpG island regions, which are relatively abundant in CG dinucleotides, a tendency toward reducing the number of CG dinucleotides was observed. Overall, our results shed further light on the fate of CG dinucleotides in the genome.
Authors' contributions
LMK designed the study. LMK collected the data. LMK analyzed data. LMK and CS wrote the manuscript. All authors read and approved the final manuscript.
We thank Marcos Antezana for helpful discussion and the guidance for part of the study, Matthew Webster, Cizhong Jiang, Shiheng Tao for providing valuable advice, Mark Stoneking for revising the manuscript as a native English speaker and helpful suggestions, and Ryan D. Hernandez for providing extra information about the method to correct the allele-frequency spectrum.
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text: Exclusive Excerpt from: "Comical Sense: A Lone Humorist Takes on a World Gone Nutty!" by Tom Purcell Every year about now, the media introduce us to the most fascinating people of the prior year. They always overlook people like Joe Horne. A tailgunner in the Army Air Corps during World War II, Horne and his crew enjoyed 11 successful missions. [Read More]


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About Us
Welcome to The Shakespeare Inn
You will find The Shakespeare Inn in Summer Row Birmingham within a short stroll of Snow Hill Station, Jewellery Quarter and Bull Ring Shopping Centre - however you won't find another like it.
Step in to discover a traditional pub of unique character, revered for its eclectic range of real ales and its quality pub food, which are served, as they should be, with a generous measure of famous British hospitality.
A fascinating past
This glorious red-brick Victorian pub with its grand arched windows is where the goldsmiths and silversmiths from the nearby Jewellery Quarter once quenched their thirsts. In the mid-19th century, Birmingham's jewellery trade was the biggest in the land. In 1861, 7,500 people were engaged in the business. They were the best-paid workers in the city. By 1880, Birmingham contained 700 workshops. It was the heyday of the city's jewellery trade. At The Shakespeare they found laughter, fine beer and a moment or two of privacy in the pub's separate rooms. The rooms in many similar pubs from the era have since been opened up. But not at The Shakespeare where a moment of quiet peace over a pint and a good meal is as delightful as it was in the bustling days of Birmingham's well-paid metalworkers.
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Unlike men, jewelry shouldn't be the strong, silent type. Mom prefers her signature pieces to be, well, like a signature: personal, expressive, almost a natural part of her identity. Delicate yet outspoken, this brass, keepsake ID cuff from Jook & Nona sits pretty on her wrist, while speaking volumes about her passions and individuality.
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Can Mainstream Rock Music Survive
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July 22 2013, 08:13 PM
Rear Admiral
Location: So. Cal.
Re: Can Mainstream Rock Music Survive
EmoBorg wrote:
JirinPanthosa wrote:
Rock music is good enough
to be on the mainstream charts.
There was great rock music that was also popular in the 60s and 70s, but it was not popular because it was great. The Beatles wrote some great songs, and they were popular because they were given cute personalities and ran from one limo to the next.
That is a cynical way of looking at things.
I think 'ignorant' is more accurate. Others have already pointed out the fallacy in what Jirin wrote about Elvis so I won't belabor that point.
The Beatles were popular because they wrote great songs and also did great covers. The fact that they had a great look and pleasing personalities only enhanced their popularity. Eventually the mainstream caught on to the fact that Lennon/McCartney were one of best pop/rock writing duos ever, which is the reason the Beatles are held in such high esteem to this day both artistically as well as commecially.
Someone else can straighten him out baout the 70's.
Duckman: I'll never forget the last thing my father said to me...
Cornfed: "Careful son, I don't think the safety's on"?
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Boston, October 14-17
2015 ACEC Fall Conference Keynote Speakers
Dr. Robert Ballard
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T.Y. Lin/Moffat & Nichols San Francisco-Oakland Bay Bridge East Span Wins Grand Conceptor Award
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So LO had his 1 year appt yesterday, and the nurse said his height was 28.8 inches, and he was in the 95th percentile. I was shocked he went from 33rd percentile to the 95th, and I didn't even realize he was tall. When I got home and looked at the growth chart they gave me, it was confusing to me, and nowhere on it did I find any indication he was in the 95th percentile.
So my question is, how tall are your LO's, and what percentile are they in? Did our nurse just make a mistake by writing "95th percentile" on the paper she gave us? Maybe she meant 45th?


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2013 Belguardo Rosé IGT Toscana, Mazzei(12x75cl)
Beautiful light cherry red in the glass and rose petals on the nose. In the mouth there is a poised balance of acidity, alcohol and body, and the short period in wood adds to mouthfeel, structure and complexity, without overwhelming the succulent red fruit characteristics.
2013 Bonizio Toscana Rosato IGT, Cecchi(6x75cl)
Made by one of Tuscany's finest producers, this pale pink rosé has a delicate floral character reminiscent of summer roses, followed by hints of wild berry and raspberry. The medium bodied, fruity palate has a refreshing acidity that makes this everyday drinking style perfect with pastas, grilled chicken and barbequed fish.
2014 Arpeggio Rosato, Settesoli(6x75cl)
On the nose this wine displays aromas of sweet raspberries and strawberries with delicate floral notes. The palate is lively bursting with crisp red berry flavours and a good persistent finish.
NV Sangiovese Poggio della Quercia IGT Rubicone, Contri(6x75cl)
Bright ruby red in the glass with aromas of forest fruits, a medium bodied palate and a delicious food-friendly freshness.
2006 Brunello di Montalcino, Vigna del Fiore, Fattoria Dei Barbi(6x75cl)
Gorgeous aroma of crushed currants and berries. Full-bodied, with well-integrated tannins and a long, expressive, fruity finish. This is a very special wine, rich, with an ample range of fruity aromas, and very elegant.
2007 Coevo IGT, Cecchi(6x75cl)
The Sangiovese in this vintage was generous and of outstanding quality, first as grapes and then as juice, bestowing its Chianti-zone violet and earthy aromas, while at the same time displaying the highest elegance and persistence. This was complemented by the lush fruit of the Merlot, the smoke of the Petit Verdot, and the vibrancy of the Cabernet Sauvignon. There is beautiful choreography in the balance between the velvety tannins and alcohol in this new vintage.
2013 Chianti Gli Scudi, Cecchi(12x37.5cl)
Chianti Cecchi is characterised by a red ruby colour, which tends towards granite red when aged. On the nose it is intensely aromatic with notes of violets. On the palate it is well balanced with the classic signature of Chianti which make it such a good match with food.
2013 Rosso di Montepulciano, Poliziano(6x75cl)
A young and fruity wine, full bodied but not aggressive, it displays a good balance of complexity and drinkability.
2012 Chianti Natio, Organic, Cecchi(6x75cl)
Natio is characterised by a lively, ruby red colour and a fruity, vinous nose. It is a soft, well-structured and balanced wine with aromatic hints of cherry, blueberry and plum.
2010 Chianti Classico Riserva Ris. di Famiglia, Cecchi(6x75cl)
The wine is characterised by a clear and intense ruby red colour. The aroma is full and persistent and is characterised by hints of mature, dark fruit, spices and a slight smoky finish. On the palate it is concentrated and elegant with supple tannins.


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So this wasn't in one of my guesses, but Tad Smith, the former CEO of RBI USA, is joining Cablevision (NYSE: CVC) as the president of local media, a new division within the cable/media conglom. Starting Sept 1, he will oversee Newsday Media Group, News 12 Networks and other interactive ventures still in development, and will report to COO Tom Rutledge. The new group is meant "to more effectively organize its local media and programming assets under one business unit."
He left RBI USA earlier last month as the parent Reed Elsevier (NYSE: RUK) put some of the RBI USA books for sale.


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In the realm of the basketball court, James has been superb.
That is, a just society collects taxes to meet its duties to every person in its realm—which are also its duties to God.
Defend the realm: The Authorized History of MI5 by Christopher Andrew is one such tome.
late 13c., "kingdom," from Old French reaume, probably from roiaume "kingdom," altered (by influence of Latin regalis "regal") from Gallo-Romance *regiminem, accusative form of Latin regimen "system of government, rule" (see regimen). Transferred sense "sphere of activity" is from late 14c.


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Music Cruises 2015 dates – itineraries, schedule, information and all you need is here to compare. We offer you a list of Classical music concerts and dance cruise specials on deals to visit Caribbean, Europe and Australia on a big cruise ship vacation. Caution – music cruises are super fun, generally promoting a lot of drinking and dancing activities. The cruise drinking and dancing fun generally involves big money spending. The survey is integrated with Themed Cruises.
Very special are also all the music concert cruises on big river ships in Europe. For music and dance themed sailings, the list of best cruise ship lines to choose from includes Carnival, Royal Caribbean, NCL (Norwegian), Princess, Holland America, Avalon (European rivers), the UK's Saga and P&O.
The "Dance-Music Cruise" experience
Themed "Music" cruises
Themed as "Music Cruises" deals are from the list of the industry's newest inventions. They are very similar to all the music concerts arranged at land-based facilities (music halls, theaters, stadiums, etc. And since modern cruise ships can accommodate from 2500 (on average) to more than 5000 people, these so special marine vessels become the perfect place for the mixed "music concert and party" cruise vacation the world has never seen before.
From what Wikipedia have said about music – it's the art form "whose medium is sound and silence". However, on cruise ships there's no such thing as silence – it's party time all the time! The word "music" derives from Greek "mousike" meaning the "art of the Muses". And what is better than a Muses-inspired vacation of several days at sea, right?
- Yo!
- -What?
- Great music, dancing, food, drinks, party and fun in one cruise package?
- -So?
- You want it?
- -Absolutely!
- Just ask the cucaracha performers here – they know all about it.
Themed "Dance" cruises
The dance cruise experience is a major part of the "Music Cruise" specials – especially when famous bands and singers are involved in these action. And these "musical" deals suggest a hell of a lot dancing on the ship. Imagine you can enjoy (if fortunate enough) your super cool band's performance at sea. there are some truly unique sailings, which include huge crowd dancing parties featuring NKOTB (with the "New Kids On The Block" celebrities),
Christian-themed music cruises are another unique offer in this category. On those you'll enjoy the company of hundreds and even thousands of like-minded folks sharing your ideas of God, right and wrong. And quite often, preachers there dance and enjoy the music more than the audience itself.
Popular musical genders on the specially themed music and dance cruises are Rock, Country and Folk bands. And Classical music and Jazz themed cruises offer one truly sophisticated experience at sea. Often music-themed sailings are combined with specials from the category of Food and Wine cruises. These are usually Jazz- or Classic music themed (often river cruise) deals, offering a gourmet voyage on some of the Europe's biggest rivers, such as Danube, or Rhone and Seine in France.
P&O Cruises UK ships offer each year several Music Cruises leaving from Southampton, and their Australia brand may offer such themed deals from Sydney, Australia. Most of them are Mediterranean cruises from Southampton, and Cruises To Nowhere from Sydney – i.e. without additional ports of call (which significantly lowers their cost by not including port charges).
How much do "Music Cruises" cost, what is included in prices?
Your dance/music cruise infrastructure is pretty much like a normal sailing – but it's not, ok? The cruise part as always, include tanning, swimming, drinking, dining, sleeping (with the "repeat until" command) summarized as "easy big time fun". Your "music cruise tickets" prices are inclusive of all meals on the boat, and add to that the 24-hr room service onboard. This means all main dining rooms and the buffet dining, specialty restaurants charge extra (from ~$20 to $50 per meal). Alcohol, soda and soft drinks are not in the list of inclusions.
Beware – enjoying the music cruise fun in a not healthy and not cheap combination with lots of beverages could cost you way more than the ticket itself. Virtually all music and dance cruise deals are on round-trip departures from some of the world's biggest cruise ports – like Miami and Fort Lauderdale in Florida, NYC New York, Boston MA, Los Angeles, Southampton UK, Sydney AU.
Music Cruises 2015 themed Classic, Folk, Country, Rock, Jazz
In the table below there are internal links which redirect to our cruise ships schedule pages, and external links for additional info. At our ship links you will find all sailing dates in the ship's cruise calendar. Our articles also feature indicative prices to compare on all departures, and the ship's current location. External links are usually to the organizer of the music-themed cruise, and you can also call them for more details.
|music theme / title
|2015 departures dates
|ship / line (internal links to the ship's schedule)
|length / itinerary
|information (call for details)
|NCL Norwegian Pearl
|"22nd Annual Where The Action Is Cruise"
|Jan 17
|Ruby Princess
|7-day Eastern Caribbean from Fort Lauderdale to Nassau, St. Thomas, St. Maarten and Princess Cay
|"Legendary Rhythm & Blues Cruise"
|Jan 18
|HAL ms Nieuw Amsterdam
|7-day Eastern Caribbean from Ft.Lauderdale FL to Grand Cayman, Roatan, Costa Maya
|HAL ms Eurodam
|"Rock Legends Cruise IV 2016″
|Jan 21
|RCI Independence of the Seas
|5-day Grand Turk, Turks and Caicos
|"Celts of the Caribbean Folk Music Cruise"
|Feb 8
|NCL Norwegian Dawn
|7-day Caribbean Celtic Celebration at Sea
|"Beatles Tribute Cruise featuring The Return"
|Feb 16
|RCI Enchantment of the Seas
|4-day Bahamas round-trip from Port Canaveral to Nassau and Coco Cay
|RCI Liberty of the Seas
|"2015 Making Waves Cruise with The Embers feat. Craig Woolard"
|Feb 22
|Carnival Pride
|7-day Western Caribbean
|"The Flashback Cruise"
|Feb 27
|Norwegian Cruise Line TBA
|5-day from Miami to Bahamas and Private Island
|"Decades Of Rock & Roll Oldies"
|Mar 8
|RCI Adventures Of The Seas
|7-day Southern Caribbean round-trip from San Juan, visiting Barbados; St. Lucia; Antigua; St. Maarten; St. Croix
|"Journey: Carnival Live Concert Series"
|Mar 15
|Carnival Splendour, Carnival Liberty
|7-day Caribbean Carnival Concert Series
|"Little Big Town"
|Mar 28
|Carnival Fascination, Carnival Fantasy
|5-day Caribbean Carnival Concert Series
|"Mississippi River Music Cruises"
|Apr 11, May 30, Aug 29
|American Cruise Line – Queen of the Mississippi
|7-day Mississippi River
|"Smokey Robinson"
"Rascal Flatts"
|April 18, 19, 20
May 2, 3, 4
|Carnival Paradise, Carnival Breeze, Carnival Ecstasy
|7-day Caribbean Carnival Concert Series
|"Monsters of Rock – Poseidon's Revenge"
|Apr 18
|MSC Divina
|4-day Bahamas round-trip from Miami, visiting Nassau
|(855) 505-6672
|"Maxwell and The 7 Seas"
|May 3
|RCI Freedom of the Seas
|7-day Eastern Caribbean from Port Canaveral, FL to the Bahamas, St. Thomas and St. Maarten
|"Cruising Alaska With Ty Herndon, Jamie O'Neal, and Andy Griggs"
|May 16
|NCL Norwegian Jewel
|8-day Alaska round-trip from Seattle, WA
|"Elvis Theme Cruise"
|May 30, Dec 5
|American Queen Steamboat Company – American Queen
|9-day Lower Mississippi River
|"Styx: Carnival Concert Series"
|Jun 14
|Carnival Sunshine
|5-day Caribbean Carnival Concert Series
|"Styx: Carnival Concert Series"
|Jun 19
|Carnival Ecstasy
|3-day Bahamas Carnival Concert Series
|Jun 29
|Avalon Waterways – Avalon Scenery and Creativity
|10-day/15-day Seine and Rhone Rivers
|Avalon Waterways – Avalon Impression
|12-14-day Rhine, Main and Daunbe Rivers
|Paul Gauguin
|10-day Society Islands and Tuamotus round-trip from Papeete
11-day/13-day Society Islands, Cook Islands, Tonga and Fiji
|NCL Norwegian Sky
|"Divine Jazz Cruise – Alaska"
|Aug 28
|Celebrity Cruises – Celebrity Solstice
|8-day Alaska round-trip from Seattle
|"Jazzdagen European River Cruise"
|Sept 22
|AMA Waterways – AmaLyra
|7-day Danube River
|"Legendary Rhythm and Blues Cruise"
|Oct 24
|HAL ms Westerdam
|7-day Caribbean round-trip from Ft. Lauderdale to Key West , New Orleans, LA, Cozumel
You can share/like/rate our review on Music Cruises 2015 collection of classical concerts and dance cruise specials via the social buttons. We are constantly updating this section of our Themed Cruises group, so visit us again soon for latest updates on sailings from USA ports to Caribbean, in Europe from UK and other countries, and from Australian ports. You can also follow shipcruise.org at Google Plus and Tweeter for our latest "Music Cruises" news. Bye for now, and enjoy the floating disco experience at sea!


text: The Impact of War Army Answers to Family Problems from War July 31, 2007 Dolores Johnson, director of Family Programs for the Army, says the Army is taking measures to help families better cope with the stresses of deployment and to prevent abuse. A new study shows an increase in the rate of child abuse when one parent is deployed. Listen Loading… Playlist Download Embed Embed Close embed modal <iframe src="http://www.npr.org/player/embed/12385672/12385673" width="100%" height="290" frameborder="0" scrolling="no">


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33 years of experience
Suite B201
Scottsdale, AZ 85258 Phone number & directions
Patient Reviews
Patient Reviews ? Write a Review
Overall Rating:
Total Ratings
Total Reviews
Very kind and compassionate, listen wells and takes positive action
My father has been going to Dr. Lugo for years. The times I have gone with my father to his appointments,Dr. Lugo takes his time and makes sure that you understands what he is explaining. He is a great doctor
I have been a patient of Doctor lugo almost 16 years now. he is very caring and will take time to listen to your medical issues and makes sure your concerns are addressed. No matter how busy his office is, I never feel he is rushing me out. I know that most times just visiting with him makes me feel better. He will also take all the time needed to make sure you understand what is going on and how to get back on the road of health. I think he is the great doctor and I wish he and his family the very best.
I have been seeing Dr. Lugo for about 14 years. He is always patient and knowledgeable and has many years of experience. He explains how things work rather than just giving medication for everything. His referrals are excellent as well!
Dr.Lugo is rude, his front desk person Sherie is extremely hateful. Dr. Lugo does not give you the time of day. Dr. Lugo does not get any stars in my book!!
Dr. Lugo is always welcoming and giveseach patient the time to feel comfortable.All questions are answered and one leavesfeeling that they have had time with anhealthcare professional.The receptionist and nurses are alsoA-1. They care and it is obvious.
Abandoned by Dr. Lugo, horrible bedside manners, rude staff. I would not recommend this Dr. to anyone!
The staff is rude, especially Shere who runs the front desk, very hateful, Dr. Lugo can't wait to get you out the door, does not show compassion, I would not refer this Dr. to anyone!
The Doctor takes a common sense approach to my questions and explains things in terms I can understand. He's not just a medication prescriber.
I am so glad to have found a Doctor like Steven Lugo, puts your mind at ease, very caring, great staff. I couldn't have found a better Doctor. I highly recommend Dr. Lugo to friends and family.
Dr. Lugo is the best doctor ever!! I would tell anyone looking for a general doctor to use him. He is so caring and nice. I trust him and think very highly of him and his staff.
Myself, my wife and our grown daughters all use Dr. Lugo and we have for about 10 years. We have been very happy with the amount of time he spends with us on every visit and the exceptionally easy way he explains his diagnosis. We wish him every success and we heartily recommend anyone in need to find out about his practice.
Office staff courteous and caring. Dr. Lugo spends as much time with you as you need. He explains the diagnosis to you in a manner you can understand. Outstanding bedside manner. A physician you can trust!
Takes his time...he and the office staff are friendly! A great family doctor...


text:
k well i'll try re-downloading it, maybe it will work this time
yeah i thinks so.
well its over with now
Good for you!
Please Click the "Thanks" Button below if my post have helped you! THANKS!
Not necessary. Did you try playing SSBB using IOS 222?
if you do and still gets a black screen, try to redownload your cIOS 222. If black screen problem still occurs, most likely its a bad dump.
Also, a thing to note is that if you are ripping it from the disc itself, at the point of ripping, your USB Loader should have the settings of having cIOS 222 as the default IOS instaed of the normal cIOS 249.
Please Click the "Thanks" Button below if my post have helped you! THANKS!
Before trying to play it using IOS 222 I had not a black screen but "a error occured when trying to read the disc...". When I tried to play it using 222 then the black screen came. I will try redownload cIOS 222 and will reply.
i had the same problem with you. well, its a bad dump for my case. so the case may apply to you too. I tried to rip SSBB with my wiiflow loaded with cIOS 249.
What i did was i changed and try using cIOS222 to load wiiflow and try ripping the game all over again... whoala! it works now. (THIS IS IMPORTANT: In this case, the game was ripped by USB Loader with cIOS 222 as the default IOS.)
Please refer to this thread, it might help you:
Please Click the "Thanks" Button below if my post have helped you! THANKS!
Ok thanks, i got it to work. What I did is I tried to rip the game using cIOS38 rev17 with USB Loader GX and it worked perfectly.
Thanks for all the help.


text:
Do you think wearing on-body cameras on duty should be mandatory?
The Los Angeles Police Department will make the case that it no longer
requires federal oversight, during a June 15 hearing in front of U.S.
District Court Judge Gary Feess, the Los Angeles Times reports.
Several years of court-ordered reforms appear to be paying off for the
Los Angeles Police Department, which has made significant gains in the
opinions of Angelenos, according to a Harvard University study.


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Stuffed Zucchini
20 Aug 2009
|4 , scrubbed and cut in halves lengthwise (Each About 4 1/2 In. Long)
|Chopped onion
|1⁄2 Cup (8 tbs)
|Olive oil
|1 Tablespoon
|Dry bread crumbs
|3 Tablespoon
|2 Clove (10 gm), minced
|Minced parsley
|2 Tablespoon
|Lemon juice
|1⁄2 Teaspoon
|1⁄2 Teaspoon
|To Taste
|Egg yolk
|1 , beaten
|1 Cup (16 tbs) (For Deep Frying Heated To 365 F)
Hollow centers of zucchini by scooping out some of pulp; reserve.
Drop shells into boiling salted water; cook until just tender, about 4 minutes.
Chop reserved pulp; set aside.
Cook onion about 5 minutes in hot oil in a skillet.
Remove from heat.
Add crumbs, garlic, parsley, lemon juice, salt, pepper, and egg yolk to onion along with chopped pulp; blend thoroughly.
Fill zucchini shells with mixture.
Dip in a mixture of 1 egg yolk beaten with 1 tablespoon olive oil.
Coat evenly with ./me dry breadcrumbs.
Fry zucchini in heated fat about 1 minute, or until lightly browned.
Fry only as many stuffed shells at one time as will float uncrowded one layer deep in fat.
Remove with slotted spoon and drain on absorbent paper.
Rate It
0 Comments
Stuffed Zucchini Recipe


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Click here to view similar products
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The Charge Juicer Hi boasts a Tange Prestige, Seamless, custom drawn, double butted skinny cro-mo frame and custom road Tange Prestige fork, as well as Shimano 105 wheelset, and 10-speed gearing with hill-friendly…
The Charge Juicer Hi boasts a Tange Prestige, Seamless, custom drawn, double butted skinny cro-mo frame and custom road Tange Prestige fork, as well as Shimano 105 wheelset, and 10-speed gearing with hill-friendly compact chainset.
- Frame:
Tange Prestige, Seamless, custom drawn, double butted skinny cro-mo
- Fork:
Tange Prestige custom road
- Front Derailleur:
Shimano 105
- Rear Derailleur:
Shimano 105 10-speed
- Number of Gears:
- Shifters:
Shimano 105
- Chainset:
Sugino Alpina-2 500D with 50×34 tooth chainset
- Chainrings:
50 × 34 tooth
- Bottom Bracket:
FSA Square taper, sealed
- Cassette:
Shimano 105 11-25 tooth
- Chain:
- Pedals:
Wellgo Alloy Trekking
- Front Brake:
Tektro R730
- Rear Brake:
Tektro R730
- Brake Levers:
Shimano 105
- Handlebars:
Shield Classic Bend
- Stem:
Shield Road Stem
- Headset:
- Grips:
Charge U-Bend
- Rims:
Shimano RS-10 (Wheelset)
- Front Hub:
Shimano RS-10 (Wheelset)
- Rear Hub:
Shimano RS-10 (Wheelset)
- Spokes:
14G Stainless
- Front Tyre:
Continental Ultra Race 700×23c
- Rear Tyre:
Continental Ultra Race 700×23c
- Saddle:
Charge Spoon
- Seatpost:
Charge Chopstick
- Seat Binder:
Shield, bolt type
Sizing Guides
Sizing guide for Charge bikes
Buying Guides
A buying guide that offers general advice on road bikes
Customer Reviews
|Product no longer available for purchase
We offer a range of delivery services for our UK and International customers. UK Customers can select our FREE standard delivery option on most non bike orders over £20. Or if you're in a hurry you can upgrade to our Next Day, Saturday or Sunday delivery services. You can also use our free Click & Collect service, where you can collect your purchases from a choice of over 50 Evans Cycles stores. International customers can benefit from FREE delivery on most orders and save UK VAT if we are shipping outside of the EU.
Bike build & delivery
UK bike delivery charge includes assembly by our fully trained mechanics, pre-delivery inspection and safety check, packing in our custom bike box, multi-tool and delivery from only £9.99 per bike.Click here to see how we deliver your bike
Standard, Next Day, Saturday & Sunday UK delivery
We offer a FREE standard delivery service on orders over £20, as well as Next Day, Saturday & Sunday delivery options to UK addresses. Click here for more details
Click & Collect
Using our Click & Collect service your order will be delivered to a choice of over 50 Evans Cycles stores nationwide for collection. This service is FREE of charge for all orders. To check store stock and collection times, use the "Check store stock" button above. Click here for more details
International delivery (Incl BFPO, ROI, Channel Island & Isle of Man)
We offer a FREE delivery service on most International orders. Orders delivered outside the EU are exempt from VAT. To calculate the charges for your order simply add products to your basket and proceed through the checkout process, where you will need to enter your delivery details. Our website will present you with the relevant delivery options and the charges for your basket of goods. Click here for more details.
Easy Returns
Our priority is to ensure that you are highly satisfied with your purchase. In the unlikely event that you are not, please feel free to return your goods within 90 days of the purchase date for a full exchange or refund. Returns can be made in your local store or sent back to our distribution centre.


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YIELD: Makes 12 servings
Preheat oven to 350°F. Spread bread on 2 large rimmed baking sheets. Bake until just golden, stirring occasionally, about 10 minutes. Transfer to very large bowl.
Combine chicken broth and 1/3 cup Madeira in large saucepan. Simmer mixture 5 minutes. Remove from heat. Add porcini mushrooms. Cover and soak until porcini are tender, about 15 minutes. Drain porcini through sieve set over medium saucepan, pressing on porcini to extract as much liquid as possible. Coarsely chop porcini. Set mushroom broth and porcini aside.
Melt 2 tablespoons butter in heavy large skillet over medium-high heat. Add leeks and carrots and sauté until carrots are crisp-tender, about 6 minutes. Transfer to medium bowl. Melt remaining 3 tablespoons butter in same skillet over medium-high heat. Add crimini mushrooms and sauté until liquid evaporates and mushrooms are golden, about 6 minutes. Add shallots and reserved porcini mushrooms; sauté 1 minute. Add remaining 2/3 cup Madeira and cook until liquid evaporates, about 2 minutes. Add herbs and sauté 1 minute. Add to bowl with leeks. (Bread, mushroom broth and vegetable mixture can be prepared 1 day ahead. Cover separately. Store bread at room temperature; refrigerate mushroom broth and vegetable mixture.) Add vegetable mixture to bread. Season to taste with salt and pepper. Mix eggs into stuffing.
To bake stuffing in turkey:
Loosely fill main turkey cavity with stuffing. Add enough broth to remaining stuffing to moisten lightly (about 1/4 to 1/2 cup, depending on amount of remaining stuffing). Generously butter glass or ceramic baking dish. Spoon remaining stuffing into dish. Cover with buttered foil, buttered side down. Bake stuffing in dish alongside turkey until heated through, about 30 minutes. Uncover stuffing. Bake until top is just crisp and golden, about 15 minutes.
To bake all of stuffing in baking dish:
Preheat oven to 350°F. Generously butter 15x10x2-inch square glass or ceramic baking dish. Add enough broth to stuffing to moisten (about 3/4 cup to 1 1/2 cups.) Transfer stuffing to prepared dish and add mushroom broth to moisten stuffing before baking. Cover with buttered foil, buttered side down; bake until heated through, about 30 minutes. Uncover and bake until top is crisp and golden, about 20 minutes longer.


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8808 Old Branch AvenueClinton, MD 20735
Licensed for 23 years
Go back to Melissa's profile.


text:
Permits & Applications
Building Fee Schedule (pdf)
Explanations of the 2012 IRC Building Code (pdf)
You may first want to read the list of items that do not require a permit:
Work Exempt from Permit (pdf)
Trabajo Exento de permiso (pdf)
Explanations of the 2012 IRC Building Code (pdf)
You may first want to read the list of items that do not require a permit:
Work Exempt from Permit (pdf)
Trabajo Exento de permiso (pdf)
- Basement Finishing
- Application (PDF)
- Informational Handout (PDF)
- Building Permit
- Application (PDF)
- New Dwellings (PDF)
- Construction Site Erosion
- Control Requirements (PDF)
- Deck Building Permit
- Egress Window and Well Dimensions
- Informational Handout (PDF)
- Electrical Inspection
- Garages, Sheds, and Other Accessory Buildings
- Heating and Plumbing
- Lead Based Requirements – Federal Mandate
- Lightning Safety
- Lightning Safety (PDF)
- Gastite Bonding Installation (PDF)
- TracPipe Bonding (PDF)
- Wardflex Bonding Grounding (PDF)
- More...
Planning & Zoning
- Code Enforcement Complaint Form
- Form (PDF)
- Conditional Use Permit
- Application (PDF)
- Final Plat
- Application (PDF)
- Home Occupation
- Application (PDF)
- Interim Uses
- Application (PDF)
- Preliminary Plat
- Application (PDF)
- Planned Unit Development
- Application (PDF)
- Rezoning/Text Amendment
- Application (PDF)
- Sign Permit
- Application (PDF)
- Vacations Street/Easement/Other Public Reservation
- Application (PDF)
- More...
Public Works
- DNR Permit
- See the DNR website.
- NPDES Permit
- See the Minnesota Pollution Control Agency website.
- Right-of-Way Permit
- Fee Schedule (PDF)
- Permit Application (PDF)
- Permit Regulations (PDF)
- User Registration Form (PDF)
From Section 25 of the City Code
a) ROW Permit and Regulations - except as provided in the City Code, no person or public right-of-way user may obstruct or excavate any public right-of-way without first having obtained the appropriate permit from the City. See the Regulations and Permit Application documents above.
b) ROW Registration Form - Any public right-of-way user, which owns or controls a public utility facility within any public right-of-way, or any portion thereof, shall register with the City. See the User Registration Form above.
c) ROW Fee Schedule. See the Fee Schedule document above.
- Parking Permits
From Section 15-40 of the City Code
Trailers — No person in charge of any type of trailer shall park or permit such trailer, whether or not attached to a motor vehicle, to be parked upon any street in the city for more than three (3) hours in a twenty-four-hour period, unless otherwise provided. Construction trailers for contractors doing business on adjacent properties between April 1 and November 1, may park on a city street within one hundred (100) feet of the property they are doing business at. To do so, a contractor at the time of requesting a building permit, must apply for an on-street parking permit providing the location, dates and time they plan to be on a street for a construction project. The public works director may deny this permit, if there are options for the contractor to park on private property or the location is a hazard. The public works director may revoke the permit for special circumstances.
Special Use Permit — In the event that a one-time increased on-street parking duration is desired by the owner of a motor vehicle and/or trailer, a special permit may be obtained from the city provided the expanded duration is clearly defined and based on unique conditions not related to the general storage of the motor vehicle and/or trailers.
- Grading Permit
- Policy & Procedures for Street Closure


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'Cars overturned' as mass brawl breaks out in street at summer party in south east London
A mass brawl broke out in south east London last night as a summer street party turned violent.
Vogue editor-in-chief Anna Wintour was at the opening night of the US Open tennis championships in New York, where rock star Lenny Kravitz performed before the sporting action began.
27 August 2013
At first it is hard to see what artist Damien Hirst and some windswept islands in the South Atlantic mainly inhabited by oil workers, penguins and sheep might have in common.
21 August 2013
Who wouldn't want to holiday with these bonkers besties?
16 August 2013
Lionel Richie has admitted that bringing his 15-year-old daughter Sofia to London has been enough to keep his bank manager up All Night Long...
15 July 2013
Always beautiful and charming, the French resort of Saint-Tropez is at its very best before or after the summer madness, says Jo Fernàndez, as its most famous hotel reopens today
17 April 2013
Japan's Transport Ministry today said a probe into the overheating of a lithium ion battery in an All Nippon Airways Boeing 787 found it was improperly wired.
20 February 2013
Supermodel Kate Moss is said to be cleaning up her act in order to have another baby.
26 August 2012
Sarah Turner experiences the minimal luxury of the latest Aman resort to open — on the glamorous Bodrum Peninsula in Turkey
13 June 2012
Forget Bikram and Ashtanga, 2012's new breed of yogas is a lot more fun - and fierce. We put fashion blogger Bip Ling and four other writers through their postures ...
25 January 2012
Imperial Leather soap owner PZ Cussons today ramped up the expansion of its beauty division by splashing out £25.5 million on the Australian-owned Fudge Hair Care brand.
05 January 2012