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Serving Size: 1 Capsule
Servings Per Container: 30
Hydravax® High Potency Diuretic Weight Loss Solution
Proprietary Blend 1000mg
Dandelion root (standardized 50%) / **
Uva Ursi (39% Stand Arbutin) / **
Methylxanthines/ **
Magnesium/ **
Green Tea Extract (50%/ 35 % polyphenols) / **
Asparagus Concentrate / **
White willo Bark / **
Cranberry Powder / **
Couch grass / **
Corn silk / **
Juniper (4:1 extract) / **
Hydragea (4:1 Extract) / **
Buchu(4:1 Extract) / **
** No Daily Value established.
Other Ingredients: Dipotassium Phosphate' MCMC' Silicon Dioxide' Mgnesium Stearate' Titanium Dioxide' FD&C Blue 1' Ti02' Gelatin.
Due to the strength of Hydravax' please assess your tolerance by initially taking only 1 capsule upon awakening for the first 3 days. After assessment' to ensure fast and easy water weight loss' take 1-2 capsules in the AM. during special occasions or contest preparation' where short term and rapid water weight is needed' take 3 capsules in the AM. Do not exceed 3 capsules daily. Drink at least 6 to 8 glasses of water daily to stay properly hydrated when using Hydraavax Only Synedrex' Phenolox and Thyrene may be combined with Hydravax for a more customized weight loss solution.
Not intended for use by persons under 18. Do not exceed recommended dosage per day' doing so will not improve results and will result in adverse health effects. Not to be used by pregnant or nursing women or person(s) who have a pre-existing health condition including but not limited to: high or low blood pressure'cardia arrhythmia' stroke' heart /kidney /liver /thyroid disease' seizure disorder' psychiatric issues' diabetes' stimulant sensitivity or allergies' prostate inflammation' or while taking any other medication (such as' but not limited to: MAO-inhibitor or SSRI's). If you experience rapid heartbeat' dizziness' severe headache' shortness of breath' or similar symptoms' discontinue use immediately and call a health care professional. Due to dietary supplement restrictions that are found in some professional sports organizations' we recommend that you first consult that organization before taking Hydravax.
Ratings & ReviewsReview This Item
Overall Rating for Hydravax - 30 Capsules
Displaying reviews 1-1 of 1
By Jon W
from Brooklyn NY
Highly recommend!
Hydravax by Metabolic Nutrition was recommended by a body-builder friend of mine. I must say it's all that he said it was. Love it!
Everything so far!
√ I would recommend this item to a friend.
Displaying reviews 1-1 of 1
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Additionally, PureFormulas is unable to directly recommend products in relation to specific health conditions. Please contact your trusted healthcare practitioner for direct product recommendations.
If you have any general questions regarding orders or our policies and programs, please contact our Customer Happiness Team @ 1.800.383.6008
If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.


text: The LaCie Porsche Design P'9221 is more than just a place to store your files-it's a collaboration between one of the most renowned design firms in the world and LaCie. With the P'9221, we've combined speed, design, and technology to result in a different type of mobile hard drive-one that's built for performance. The P'9221 was designed especially for Mac computers, and features a stylish, sophisticated aluminum finish that matches your MacBook(r) Pro-it's stylish and functional, and looks great on the go.

subset: commoncrawl


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Mapou Yanga Mbiwa
The 22-year-old Frenchman Mapou Mbiwa captained Ligue 1 side Montpellier to the title this season and was their stalwart in defence. Mbiwa has been on terrific form this year which resulted in a call up to Laurent Blanc's provisional 25-man squad for the Euro 2012 finals. Unfortunately he was one of the unlucky two to get dropped when the squad was cut to 23. The Montpellier skipper would be a very useful signing for Arsenal, even though Thomas Vermaelen and Laurent Koscielny looked on form at the end of the season. The Gunners lack any strong back up, especially with the underperforming Johan Djourou set to leave the Emirates this summer. Mbiwa is young, but seems to have a good head on his shoulders, as shown with his league winning leadership. It has been suggested the player would cost in the region of £13m.


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Are You Sure You Know How Much You'll Need for Retirement?
By Motley Fool Staff - March 21, 2014 More on: ES3 ^STI
When it comes to retirement, a lot of investors have a specific number in mind that they would need to retire in complete comfort. What many people don't know is how to actually come up with an accurate estimate of how much money you'll actually need. Here's a quick guide to help you get started on your planning.
Estimate your annual expenses
You have probably heard of various estimates on how much of your previous income is needed to maintain a similar lifestyle in retirement, and around 75-85% seems to be the consensus. In other words, if your pre-retirement income is $100,000 per year, expect to draw around $75,000-$85,000 annually from your investments and other income sources.
However, this is not a one-size-fits-all formula. If you were a big saver in your working life, for instance, you are already used to living on a lower percentage of your salary. If you were paying a housing loan and your home is now paid off, that is an expense that no longer needs to be considered. So, it is very possible that the annual income you'll need in retirement is much lower than you think.
In your pre-retirement planning, it helps to try and eliminate as many expenses as possible before you retire (like a mortgage). Sit down and list all of your monthly expenses and consider how they might change once you retire. For example, if you have a long commute to work, you'll certainly be spending a lot less on gas or MRT/bus fares! Smaller expenses like that can really add up fast.
There have been studies that suggest that post-retirement expenses are not as much as experts think and that overall costs actually decline consistently after retiring. A recent study by the University of Michigan found that post-retirement spending for Americans is less than 60% of pre-retirement income, on average, so that could be silver lining as well for us Singaporeans.
Don't count on help!
While your expenses may be less than you may think, one thing that you should not depend on solely for income would be your Central Provident Fund (CPF) account. Last June, some statistics on CPF were compiled and for local residents above the age of 60, more than half had less than S$100,000 in their CPF account.
Houses in Singapore require a huge capital outlay and a bulk of that cost stems from an individual or couple's CPF accounts, leaving a smaller amount of liquid-cash for future use.
As such, you should be having your own savings and investments outside of CPF in order to help fund your retirement.
How you want to invest
The idea of equating the word "shares" with "risk" in retirement is a flawed one. Not all shares are risky and volatile any more than all corporate bonds are perfectly safe. Now, it would be good to stay away from exorbitantly-priced companies, but dividend-paying blue chip shares can likely be a good idea to fill up a substantial portion of any retirement portfolio.
Bonds can be great for income, but for retirement investors truly in it for the long haul, the concept of "total return" is what will keep your portfolio growing in perpetuity.
For instance, take the SPDR Straits Times Index ETF (SGX: ES3), an index tracker that basically mimics the movement of Singapore's overall stock market as represented by the Straits Times Index (SGX: ^STI). The ETF has averaged a compounded total return (dividends and share price appreciation) of 8.2% annually in the 12 years since April 2002. Depending on the time period, dividend yields could be around 2-3% with the rest of the return coming from price appreciation.
Is the "4% rule" right for everyone?
The short answer is "no", but it can be a good starting point. The "4% rule" of retirement essentially says that if you withdraw 4% of your retirement portfolio per year through interest and dividends and increase your withdrawals with inflation, your account will last for as long as you do.
The 4% rule should work if you have a healthy mix of investments, specifically, at least half of your money in dividend-stocks that will allow your portfolio to appreciate over time. If you decide that you need $60,000 per year in retirement, your "number" would be $1,500,000.
Click here now for your FREE subscription to Take Stock Singapore, The Motley Fool's free investing newsletter. Written by David Kuo, Take Stock Singapore tells you exactly what's happening in today's markets, and shows how you can GROW your wealth in the years ahead.
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The information provided is for general information purposes only and is not intended to be personalised investment or financial advice. This article was written by Matthew Frankel and first published on fool.com. It has been edited for fool.sg.
When it comes to retirement, a lot of investors have a specific number in mind that they would need to retire in complete comfort. What many people don't know is how to actually come up with an accurate estimate of how much money you'll actually need. Here's a quick guide to help you get started on your planning.
Estimate your annual expenses
You have probably heard of various estimates on how much of your previous income is needed to maintain a similar lifestyle in retirement, and around 75-85% seems to be the…


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Albuquerque hotels and motels with swimming pools that are perfect for a family are listed below. Search for cheap and discount hotel rates at hotels with a pool in or near Albuquerque, NM for your upcoming individual or family vacation. We list the best pool equipped, kid friendly Albuquerque New Mexico hotel and motel rooms for children. Review the list of Albuquerque hotels with indoor or outdoor pools below to find the perfect lodging for you and your kids.
Planning group travel? Get Albuquerque NM Group Hotel Rates or Plan your Albuquerque Corporate Meeting
Albuquerque Hotels with Outdoor or Indoor Pools
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English, Excel, 2,039kb
A cooperative global approach to the regulation of agricultural pesticides and sustainable pest management. Pesticides are widely used in agriculture and have considerable benefits by contributing to a sustainable production of food and feed. If used improperly or in an inappropriate manner, they also can present unacceptable risks to human and animal health and to the environment.
This report of a survey collates member countries' approaches to manage and mitigate the risk of pesticide use near residential areas.
OECD has published a report of a survey that provides information and recommendations on how to deal with stocks of "obsolete" pesticides in OECD member (and partner) countries. Such pesticides' obsolescence can arise for a number of reasons including product deterioration, product de-registration, and product revision.
The first version of the Globally Harmonised Submission and Transport Standard was published May 2014. The GHSTS is a standardised set of technical specifications used to assemble electronic files for any pesticide package in a predefined manner. Once the files are assembled according to the specifications, they can be transferred from a business entity to a regulatory authority and can be extracted for use in a regulatory process.
A report of the 2013 joint OECD/Swedish Chemicals Agency/European Commission workshop on the assessment and management of risks of microbial pesticides that resulted in 20 recommendations for approaches that could be taken now and areas for follow-up work to be undertaken by OECD or Member countries.
This website gives information about the regulatory approaches adopted by OECD member countries to mitigate pesticide risks to insect pollinators. Following a survey of OECD member countries, it was concluded that mitigation of risks to insect pollinators is important to all its member countries, and that mitigation is a critical component of balancing the benefits of plant protection products with potential risks to insect pollinators.
Integrated Pest Management (IPM) in agriculture is high on the agenda in many countries. IPM is about promoting the sustainable use of pesticides in the context of challenges including climate change, increasing demand for food, feed and fibres and pest resistance. OECD has launched the IPM Hub, an online focal point for information on Integrated Pest Management.
Safeguarding people's health and the environment through responsible marketing and use of pesticides in agriculture relies on regulation, and compliance with this regulation. OECD have launched an online resource to help regulators in different countries share their experiences and best practice and to act as a portal for information on pesticide compliance and enforcement.
This Bio-pesticides seminar report presents an overview of similarities and differences between species and strains within the Trichoderma genus. This fungus illustrates many general issues related to the use of micro-organisms for pest management.
The OECD has published a revision of the 2003 Emission Scenario Document on Wood Preservatives to take into account the experience gained in working with the 2003 ESD. The document has been totally restructured, emission scenarios have been updated and new, niche scenarios have been added. The document is an essential tool for Member countries working in the area of biocidal products assessment.


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Become the master of macabre when you decide to wear the officially licensed Rob Zombie Full Mask. This pale face features an "x" on the brow and authentic looking facial hair.
Tear your enemies to shreds on Halloween when you dress up in the officially licensed Rob Zombie Mike Myers Child Costume. You'll be one of the most feared slashers when you dress in this olive-colored boiler suit and top it off with this Mike Myers character mask.
Tear your enemies to shreds on Halloween when you dress up in the officially licensed Rob Zombie Mike Myers Adult Men's Costume. You'll be one of the most feared slashers when you dress in this olive-colored boiler suit and top it off with this Mike Myers character mask.
Top off your wicked zombie costume when you wear the Undead Zombie Mask. This gruesome mask features a blood-covered scalp with icy eyes and snarling teeth details.
This zombie is double trouble! The Swamp Zombie Mask has an extra scare factor. This mask features a creepy skull face and gross, swampy strands.
Top off your awesome zombie costume when you wear the Decaying Face Zombie Mask. This gruesome mask features wicked, nasty skin abrasions and black, synthetic hair.
Search the forests sniffing out flesh and blood wearing this Ancient Zombie Mask. Leather looking skin peels back around the mouth, chest, and skull revealing grotesque blood and bone. You'll look completely crazed with blue ablaze eyes. They better run fast. They'll feel your gaze from miles away.
Want to be a zombie without working real hard at it? Get this transparent male Zombie mask - it is suitably gruesome without the hassle and cleanup of makeup plus you can use it at will.
Change your appearance in an instant with this frighteningly realistic transparent Zombie female mask - no need for makeup or hassles plus you can slip in and out of costume at will.
Look as if you just clawed your way out of the crypt in this authentic looking and altogether terrifying Zombie Gauze Mask. The shredded gauze looks like the clothing your were long ago buried in; neither it or your complexion has held up very well.
…skills when you're already dead, so make it easy on yourself when you dress in the Zombie Ninja Child Costume. This awesome tunic features a skeletal chest piece and comes complete with pants with bone details, a hooded shirt with attached wrist guards, 2 gauze ties, gloves, a belt and a mask.
Maybe you're a zombie or maybe you survived a tsunami and work on the reactors - whatever character you create this antiqued silver Bio Hazard Gas Mask will add authenticity to your costume. Plus, if you just want and easy costume, pull on a hoodie and the mask and call it done!
Turn yourself into a knife wielding lunatic when you put on this Michael Myers Mask from the Rob Zombie motion picture. This creepy mask features cracked skin and hair, so you'll really look the part.
Terrify the neighborhood when you wear the officially licensed Walking Dead Moss Zombie Full Mask. This 100% latex mask features specific character details pulled right from the AMC original series.
Achieve the look of a flesh eating fiend when you wear this No Skin On Chin Zombie Mask. Wretched skin or what's left of it has leather like appearance and is covered in gashes right down to what would be your chin.
Create an incredible costume when you decide to use this officially licensed World War Z Scientist Zombie Mask. Right from the movie, this mask features impeccable detail including hair and bulging eyeballs!
Creep them out with your beyond-the grave coolness when you wear this Punk Zombie child costume. The vinyl character half mask features a mohawk and comes complete with a black jacket with molded chest and a pair of studded gloves.
Do the monster mash when you wear this Skeleton Zombie child costume. The green and tan, 100% polyester tattered shirt features white chest bones and comes complete with matching pants, gloves and a very gruesome mask with long hair.
Rise up and feast on the living when you wear this Zombie Classic boys costume. The top and pants of this zombie costume features sewn-in body parts and comes complete with a mask and attached wig along with a pair of gloves.
Perform your missions under the cover of darkness when you wear this Zombie Ninja boys costume. The gray, screaming skull print tabard, comes complete with a tattered light gray shirt with an attached hood, matching pants, a belt and a fabric face mask with attached vinyl blood covered Ninja star.
Be prepared when zombie roam the streets and have your disguise ready with this Street Zombie boys costume. The one-piece hoodie and coat features a hooded sweaT-Shirt front and comes complete with fingerless gloves and a creepy zombie mask.
You'll be about six feet under the law on Halloween when you decide to wear this Zombie Sheriff Child Costume. The tan, blood spattered and tattered jumpsuit comes complete with a matching hat, holster, zombie gloves and mask.
…like a zombie through the neighborhood or the party in this distressed Zombie Skeleton teen costume. The beige tattered shirt of this zombie costume features an exposed skeletal chest and comes complete with matching pants, black and white skeleton gloves along with an intricately detailed mask.
Create a killer backstory when you suit up in this Zombie Doctor child costume. Perhaps you were once a brain surgeon - you decide when you don these blood-spattered green scrubs, revealing gory body parts. This zombie costume come complete with gloves, surgical mask, scrub cap, and zombie mask.


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I'll be the first to admit that browsing the personal finance section at your local Barnes & Noble can be intimidating. There are hundreds of personal finance titles to choose from; it's possible to spend a small fortune trying to learn how to … [Read more...]
Busting the Millionaire Myth
We non-millionaires (last I checked, we're still in the majority), may or may not find the prospect of such wealth alluring. Those of us swayed by the sirens' song of riches may work hard to increase our income, invest wisely, and set a course to get … [Read more...]
Credit Card Alternatives
Credit card companies are raising interest rates on just about everybody these days, fueling many people's passionate disdain for using any credit card for any reason. Once upon a time, there was only one alternative to spending with credit cards: … [Read more...]
Think You Don't Need Health Insurance? Think Again
The younger we are the more we tend to think that we are invincible and do not need health insurance. Cancer, broken bones, and weird illnesses with names that we can't pronounce are all things that happen to other people and never to us---right? … [Read more...]
A Case for Local Banks and Credit Unions
I have been trying to convince my wife to switch her checking account away from Bank of America; I'm not a fan. Recently, on my post on leading financial iPhone apps, two readers asked why. Although there are pros and cons to banking both with large … [Read more...]
My Credit Card Raised My Interest Rate! Here's What to Do
Stories of credit card companies raising interest rates on just about everybody---even customers with perfect credit, no debt, and no late payments---continue to roll in. That's because the CARD Act takes effect this winter and will restrict … [Read more...]
Six Things to Know About Your Student Loans
At some point during my freshman year of college, I vaguely remember attending a mandatory 45-minute meeting in the financial aid office and signing some paperwork that had to do with my student loans. And I remember receiving notices about nine … [Read more...]
$6,500 Home Buyer Tax Credit
IMPORTANT: This article applies to a tax credit in 2009 and 2010 that has now expired. Use this information for historical purposes only. The information here does NOT apply to current tax years. Good news for prospective home-buyers: It looks … [Read more...]
Five "Forgotten" Financial Habits to Develop In Your Twenties
"I'm 25 and only make $30k a year. I've got student loans. I'm broke! Why should I care about investing?" I hear this all the time. When it comes to money, many of my peers (at least the ones not completely afraid of their finances) are concerned … [Read more...]


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Color blindness is an extremely prevalent disability, especially amongst men: according to official statistics, 1 in 12 men are color blind (although women fare better, at a rate of only 1 in 200). These rates of color blindness are part… Read more ›
Tag Archive: Tells
Realmac Software has been schooling developers on how to make great apps since 2002. So when they brought Typed to OS X back in December, I couldn't wait to get my hands on it. Two months on, I'm convinced it's… Read more ›
Hitting the gym with my girlfriend is an embarrassing affair. Not because she lifts almost as much as me, but because she's so much better at it, with the all the right form and stuff. "Move your knees farther apart.… Read more ›
LAS VEGAS — I've had a standing desk for two years now, and while it's practically the greatest piece of furniture to ever enter my life, I somehow forget to actually stand at it while working. Humanscale is all too… Read more ›
President Obama's not the only world leader to be a big iPad fan. According to a new report, Apple's tablet also has a devotee in the world's most famous royal toddler and future King of England, Prince George. The revelation… Read more ›
Ralph Nader has a message for Tim Cook: Stop listening to Carl Icahn. In a scathing letter to Tim Cook published in today's Wall Street Journal, the former presidential candidate takes Apple's CEO to task for bending to the will… Read more ›
Apple is livid that a Thai government official spilled the beans on its pending launch of two new iPhone models and requested a meeting with officials at the National Broadcasting and Telecommunications Commission (NBTC) to talk about a little thing… Read more ›
Apple's Tim Cook and Eddy Cue were invited yet again this year to the illustrious business conference put on by Allen & Company in Sun Valley, Idaho. Today they were spotted walking around and talking to reporters. The tech and… Read more ›
Apple will be working closely with the US Food and Drug Administration on future products related to the health industry, according to new information provided by the government. Back in January, The New York Times reported that Apple had met… Read more ›


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Are you Carmen Herencia?Claim your profile
Publications (15)56.48 Total impact
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ABSTRACT: It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation into hepatocytes or rather the result of the release of stem cell intracellular content with hepatoprotector properties. The effects of intact MSC transplantation were compared with the infusion of MSC lysates in an experimental rat model of acute liver failure. A more powerful hepatoprotective and antiapoptotic effect was obtained after infusion of MSC lysates than intact MSC. Changes in IL-6 levels and miRNAs might explain the beneficial effects of MSC lysates. Infusion of MSC lysates show a better hepatoprotective effect than the transplantation of intact MSC.Regenerative Medicine 01/2015; 10(1):25-38. DOI:10.2217/rme.14.59 · 3.50 Impact Factor
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ABSTRACT: Cardiotrophin-1 (CT1) has been used to prevent cell death in different models of liver injury in rats. D-galactosamine induces cell death in culture rat and human hepatocytes. The present study evaluated the cytoprotective effects of CT1 in an experimental model of apoptosis induced by D-galactosamine in hepatocytes.Journal of Surgical Research 07/2014; 193(1). DOI:10.1016/j.jss.2014.06.056 · 2.12 Impact Factor
Article: TGF-beta Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/beta-Catenin Pathways (vol 9, e89179, 2014)PLoS ONE 06/2014; 9(6). DOI:10.1371/journal.pone.0101910 · 3.53 Impact Factor
Article: FRI0167 Effect of Infliximab and Paricalcitol on Inflammation and Mineralization/Calcification of Mesenchymal Stem Cells during Osteogenic DifferentiationAnnals of the Rheumatic Diseases 06/2014; 73(Suppl 2):442-442. DOI:10.1136/annrheumdis-2014-eular.5076 · 9.27 Impact Factor
Article: TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways[Show abstract] [Hide abstract]
ABSTRACT: Transforming growth factor-β (TGF-β) is a key cytokine during differentiation of mesenchymal stem cells (MSC) into vascular smooth muscle cells (VSMC). High phosphate induces a phenotypic transformation of vascular smooth muscle cells (VSMC) into osteogenic-like cells. This study was aimed to evaluate signaling pathways involved during VSMC differentiation of MSC in presence or not of high phosphate. Our results showed that TGF-β induced nuclear translocation of Smad3 as well as the expression of vascular smooth muscle markers, such as smooth muscle alpha actin, SM22α, myocardin, and smooth muscle-myosin heavy chain. The addition of high phosphate to MSC promoted nuclear translocation of Smad1/5/8 and the activation of canonical Wnt/β-catenin in addition to an increase in BMP-2 expression, calcium deposition and alkaline phosphatase activity. The administration of TGF-β to MSC treated with high phosphate abolished all these effects by inhibiting canonical Wnt, BMP and TGF-β pathways. A similar outcome was observed in high phosphate-treated cells after the inhibition of canonical Wnt signaling with Dkk-1. Conversely, addition of both Wnt/β-catenin activators CHIR98014 and lithium chloride enhanced the effect of high phosphate on BMP-2, calcium deposition and alkaline phosphatase activity. Full VSMC differentiation induced by TGF-β may not be achieved when extracellular phosphate levels are high. Moreover, TGF-β prevents high phosphate-induced osteogenesis by decreasing the nuclear translocation of Smad 1/5/8 and avoiding the activation of Wnt/β-catenin pathway.PLoS ONE 02/2014; 9(2):e89179. DOI:10.1371/journal.pone.0089179 · 3.53 Impact Factor
Article: Magnesium Inhibits Wnt/β-Catenin Activity and Reverses the Osteogenic Transformation of Vascular Smooth Muscle Cells[Show abstract] [Hide abstract]
ABSTRACT: Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the mechanism has not been revealed so far. This work used only slightly increased magnesium levels and aimed at determining: a) whether inhibition of magnesium transport into the cell influences VSMC calcification, b) whether Wnt/β-catenin signaling, a key mediator of osteogenic differentiation, is modified by magnesium and c) whether magnesium can influence already established vascular calcification. Human VSMC incubated with high phosphate (3.3 mM) and moderately elevated magnesium (1.4 mM) significantly reduced VSMC calcification and expression of the osteogenic transcription factors Cbfa-1 and osterix, and up-regulated expression of the natural calcification inhibitors matrix Gla protein (MGP) and osteoprotegerin (OPG). The protective effects of magnesium on calcification and expression of osteogenic markers were no longer observed in VSMC cultured with an inhibitor of cellular magnesium transport (2-aminoethoxy-diphenylborate [2-APB]). High phosphate induced activation of Wnt/β-catenin pathway as demonstrated by the translocation of β-catenin into the nucleus, increased expression of the frizzled-3 gene, and downregulation of Dkk-1 gene, a specific antagonist of the Wnt/β-catenin signaling pathway. The addition of magnesium however inhibited phosphate-induced activation of Wnt/β-catenin signaling pathway. Furthermore, TRPM7 silencing using siRNA resulted in activation of Wnt/β-catenin signaling pathway. Additional experiments were performed to test the ability of magnesium to halt the progression of already established VSMC calcification in vitro. The delayed addition of magnesium decreased calcium content, down-regulated Cbfa-1 and osterix and up-regulated MGP and OPG, when compared with a control group. This effect was not observed when 2-APB was added. In conclusion, magnesium transport through the cell membrane is important to inhibit VSMC calcification in vitro. Inhibition of Wnt/β-catenin by magnesium is one potential intracellular mechanism by which this anti-calcifying effect is achieved.PLoS ONE 02/2014; 9(2):e89525. DOI:10.1371/journal.pone.0089525 · 3.53 Impact Factor
Article: Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expressions at moderately low calcium concentration.[Show abstract] [Hide abstract]
ABSTRACT: The interest on magnesium (Mg) has grown since clinical studies have shown the efficacy of Mg-containing phosphate binders. However, some concern has arisen for the potential effect of increased serum Mg on parathyroid hormone (PTH) secretion. Our objective was to evaluate the direct effect of Mg in the regulation of the parathyroid function; specifically, PTH secretion and the expression of parathyroid cell receptors: CaR, the vitamin D receptor (VDR) and FGFR1/Klotho. The work was performed in vitro by incubating intact rat parathyroid glands in different calcium (Ca) and Mg concentrations. Increasing Mg concentrations from 0.5 to 2 mM produced a left shift of PTH-Ca curves. With Mg 5 mM, the secretory response was practically abolished. Mg was able to reduce PTH only if parathyroid glands were exposed to moderately low Ca concentrations; with normal-high Ca concentrations, the effect of Mg on PTH inhibition was minor or absent. After 6-h incubation at a Ca concentration of 1.0 mM, the expression of parathyroid CaR, VDR, FGFR1 and Klotho (at mRNA and protein levels) was increased with a Mg concentration of 2.0 when compared with 0.5 mM. Mg reduces PTH secretion mainly when a moderate low calcium concentration is present; Mg also modulates parathyroid glands function through upregulation of the key cellular receptors CaR, VDR and FGF23/Klotho system.Nephrology Dialysis Transplantation 10/2013; DOI:10.1093/ndt/gft400 · 3.49 Impact Factor
Article: In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation.[Show abstract] [Hide abstract]
ABSTRACT: The present study investigates the differential effect of two vitamin D receptor agonists, calcitriol and paricalcitol, on human aortic smooth muscle cells calcification in vitro. Human vascular smooth muscle cells were incubated in a high phosphate (HP) medium alone or supplemented with either calcitriol 10(-8)M (HP + CTR) or paricalcitol 3·10(-8) M (HP + PC). HP medium induced calcification, which was associated with the upregulation of mRNA expression of osteogenic factors such as bone morphogenetic protein 2 (BMP2), Runx2/Cbfa1, Msx2, and osteocalcin. In these cells, activation of Wnt/β-catenin signaling was evidenced by the translocation of β-catenin into the nucleus and the increase in the expression of direct target genes as cyclin D1, axin 2, and VCAN/versican. Addition of calcitriol to HP medium (HP + CTR) further increased calcification and also enhanced the expression of osteogenic factors together with a significant elevation of nuclear β-catenin levels and the expression of cyclin D1, axin 2, and VCAN. By contrast, the addition of paricalcitol (HP + PC) not only reduced calcification but also downregulated the expression of BMP2 and other osteoblastic phenotype markers as well as the levels of nuclear β-catenin and the expression of its target genes. The role of Wnt/β-catenin on phosphate- and calcitriol-induced calcification was further demonstrated by the inhibition of calcification after addition of Dickkopf-related protein 1 (DKK-1), a specific natural antagonist of the Wnt/β-catenin signaling pathway. In conclusion, the differential effect of calcitriol and paricalcitol on vascular calcification appears to be mediated by a distinct regulation of the BMP and Wnt/β-catenin signaling pathways.AJP Renal Physiology 08/2012; 303(8):F1136-44. DOI:10.1152/ajprenal.00684.2011 · 4.42 Impact Factor
Article: Nuclear Translocation of β-Catenin during Mesenchymal Stem Cells Differentiation into Hepatocytes Is Associated with a Tumoral Phenotype[Show abstract] [Hide abstract]
ABSTRACT: Wnt/β-catenin pathway controls biochemical processes related to cell differentiation. In committed cells the alteration of this pathway has been associated with tumors as hepatocellular carcinoma or hepatoblastoma. The present study evaluated the role of Wnt/β-catenin activation during human mesenchymal stem cells differentiation into hepatocytes. The differentiation to hepatocytes was achieved by the addition of two different conditioned media. In one of them, β-catenin nuclear translocation, up-regulation of genes related to the Wnt/β-catenin pathway, such as Lrp5 and Fzd3, as well as the oncogenes c-myc and p53 were observed. While in the other protocol there was a Wnt/β-catenin inactivation. Hepatocytes with nuclear translocation of β-catenin also had abnormal cellular proliferation, and expressed membrane proteins involved in hepatocellular carcinoma, metastatic behavior and cancer stem cells. Further, these cells had also increased auto-renewal capability as shown in spheroids formation assay. Comparison of both differentiation protocols by 2D-DIGE proteomic analysis revealed differential expression of 11 proteins with altered expression in hepatocellular carcinoma. Cathepsin B and D, adenine phosphoribosyltransferase, triosephosphate isomerase, inorganic pyrophosphatase, peptidyl-prolyl cis-trans isomerase A or lactate dehydrogenase β-chain were up-regulated only with the protocol associated with Wnt signaling activation while other proteins involved in tumor suppression, such as transgelin or tropomyosin β-chain were down-regulated in this protocol. In conclusion, our results suggest that activation of the Wnt/β-catenin pathway during human mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype.PLoS ONE 04/2012; 7(4):e34656. DOI:10.1371/journal.pone.0034656 · 3.53 Impact Factor
Article: 282 NUCLEAR TRANSLOCATION OF ß-CATENIN DURING MESENCHYMAL STEM CELLS DIFFERENTIATION INTO HEPATOCYTES IS ASSOCIATED WITH LIVER CANCER-RELATED PROTEINSJournal of Hepatology 04/2012; 56:S117. DOI:10.1016/S0168-8278(12)60295-5 · 10.40 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The involvement of bone marrow hematopoietic stem cells (BMHSC) mobilization during liver regeneration from hepatectomized patients is under debate. The main aim of this study was to investigate the role of BMHSC mobilization after hepatic resection in 33 patients with liver disease. Mobilization of CD34(+) BMHSC after 72 h of surgery was found in peripheral blood of some, but not all, of the hepatectomized patients. These CD34(+) cells co-expressed other stem cells markers. The patients without BMHSC mobilization showed high levels of circulating and liver tissue BMHSC (CD34(+) cells) previous to surgery. Therefore, two types of patients: "mobilizers" and "non-mobilizers" were distinguished based on the values of CD34(+) cells before and after surgery. Changes in cytokines involved in the hepatic regeneration (HGF and TGF-β), and in BMHSC mobilization process (SCF, SDF-1, IL-12, or MMP-2), were detected in both groups. In addition, a higher activation previous to surgery of the SDF-1/CXCR4 axis in liver tissue was observed in non mobilizers patients compared to mobilizer patients. BMHSC mobilization seems to be associated with variations in the levels of cytokines and proteolytic enzymes involved in hepatic regeneration and bone marrow matrix degradation. Hepatectomy may be an insufficient stimulus for BMSHC mobilization. The pre-hepatectomy higher levels CD34(+) cells in peripheral blood and liver, associated to the activation of hepatic SDF-1/CXCR4 axis, suggest a BMHSC mobilization process previous to surgery in non mobilizer patients.Journal of Gastrointestinal Surgery 04/2011; 15(8):1459-67. DOI:10.1007/s11605-011-1541-7 · 2.39 Impact Factor
Article: Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats.[Show abstract] [Hide abstract]
ABSTRACT: Melatonin and S-adenosyl-l-methionine (SAMe) prevent oxidative stress and tissue dysfunction in obstructive jaundice (OJ). Lipid peroxidation is exacerbated in the presence of trace amounts of iron (Fe). The study investigated the regulation by melatonin and SAMe the induction of oxidative stress, iron metabolism disturbances and tissue injury in an experimental model of OJ. Different parameters of lipid peroxidation, antioxidant status, tissue injury and Fe metabolism were determined in liver and blood. OJ induced Fe accumulation in liver, and increased transferrin (Tf) saturation and loosely bound Fe content in blood. Melatonin, and SAMe at lesser extent, enhanced protein Tf content in liver and blood, that reduced loosely bound Fe content in blood. Melatonin and SAMe did not affect ferritin (FT) and Tf mRNA expression, but reduced Tf receptor (TfR) mRNA expression in liver. In conclusion, the effect of melatonin and SAMe on Fe metabolism may be included in the beneficial properties of these agents on lipid peroxidation and tissue injury induced by OJ.Chemico-Biological Interactions 08/2008; 174(2):79-87. DOI:10.1016/j.cbi.2008.05.016 · 2.98 Impact Factor
Article: [Mechanisms of liver cell injury].[Show abstract] [Hide abstract]
ABSTRACT: Liver cell death is triggered by a number of insults arising from the external environment or from within the cell. These insults may engage cell surface receptors with death domaines leading to a proteolytic cascade involving initiator and executioner caspases and an apoptotic demise. Alternatively, the insults may profoundly disrupt mitochondrial function and result in loss of homeostasis accompanied by activation of hydrolases and a necrotic or lytic demise. The distinction between apoptotic and necrotic cell death has become blurred recently by the recognition that the same stimuli can induce either form of cell death as well as caspase independent apoptosis. Mitochondria play a key role in the shape of cell death; selective release of mediators amplifies the apoptosis program and profound loss of mitochondrial function leads to necrosis. Reactive oxygen metabolites and nitric oxide participate as intitiating factors and modulators. The extensive knowledge gained in recent years about the mechanisms of cell death will undoubtedly lead to new and exciting advances in the prevention and treatment of liver diseases. Important targets include death receptors, death signaling mechanisms, the mitochondrial permeability transition and approaches which selectively inhibit or activate cell death in parenchymal versus nonparenchymal cells.Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 08/2007; 99(7):405-10. · 1.32 Impact Factor
Article: Mecanismos de lesión hepatocelularRevista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 01/2007; 99(7). DOI:10.4321/S1130-01082007000700007 · 1.32 Impact Factor
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ABSTRACT: Ovarian hormone depletion in ovariectomized experimental animals is a useful model with which to study the physiopathological consequences of menopause in women. It has been suggested that menopause is a risk factor for the induction of several cardiovascular disorders. In the present study we analyzed the effects of ovarian hormone depletion by ovariectomy (OVX) in a model of oxidative stress and cardiopathy induced by adriamycin (AD). To evaluate these effects, we measured parameters related to cardiac damage (creatinine kinase, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase) and oxidative stress (malondialdehyde, catalase, superoxide dismutase, glutathione peroxidase, reduced glutathione, nitric oxide and carbonyl proteins) in cardiac tissue and erythrocytes. OVX was found to alter all markers of oxidative stress and cell damage in cardiac tissue. Similarly, the OVX-derived loss of ovarian hormones enhanced cardiac damage and oxidative stress induced by AD. Our results suggest that antioxidant status in cardiac tissue and erythrocytes is seriously compromised by OVX during the cardiomyopathy induced by AD in experimental animals. In conclusion, the absence of hormones caused by OVX or menopause may induce or accelerate pre-existing cardiovascular dysfunctions.Gynecological Endocrinology 03/2006; 22(2):74-9. DOI:10.1080/09513590500490249 · 1.14 Impact Factor
Top Journals
University of Cordoba (Spain)Cordoue, Andalusia, Spain
Instituto de Salud Carlos III
Madrid, Madrid, Spain
- CIBER of Hepatic and Digestive Diseases (CIBEREHD)
Hospital Universitario Reina SofíaCordoue, Andalusia, Spain
Instituto Maimónides de Investigación Biomédica de CórdobaCordoue, Andalusia, Spain


text:
I enjoyed it a lot but my suggestion would be to gut it out and finish Mass Effect then go on to Mass Effect 2 because it is better by leaps and bounds. If that doesn't grab you either, then I guess it just isn't for you.
Does Mass Effect suck?
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I thought the story was what drove me to go through the game. I did think though that there are many faults with the 1st game but it is such a awesome story and game that it overshadowed the flaws. Keep at it for a little while longer I would say and then if your still not happy turn it off and sell it dude.
I liked the game alot because of the writing. It's one of the very very very few games where the writing isn't complete garbage. The Interface, even on the PC version, is honestly a clusterfuck. I don't think the battles are very tactical, like hoped them to be. But since the writing is interesting and the fighting gameplay still decent the game turns out to be fun, for me. So if you really care about the writing I would just drop ME, I don't think it's too gripping. Do you usually play RPGs or other kinds of text heavy games?
I think a lot of AAA games don't age very well. Like gears of war. I still think GoW is fun, but if you played GoW2 before GoW u might not be able to enjoy it, since it's the same as the sequel just worse. I once skipped a couple of years of gaming and Deus Ex fell into those years. I have an incredibly hard time to get into any of those games. 3D games just don't age very well in general I find (Well, or at least most of them. Quake and UT99 are still cool). Just look at the textures, they give u a headache!! On the other hand, I recently played the first Xcom and the first Fallout. I still could easily get into those games. Once you adjust to the 640x480 resolution, you're fine. I think its because those games don't rely on graphics purely based on eyecandy. Another reason might be that the gameplay is not happening in the rendered world but somewhat abstracted from it.
" I have always had trouble getting into older games that other people thought were great. I've picked up games like Gears and Half-Life way too late and never gotten into them. I think I'll stick with ME until I reach around the 10 hour mark and if I'm still not enjoying it I'll just move on. From what I've heard on forums, the game takes up to 40 hours to complete and I'm not going to play a game I don't like for that long... "
@Catarrhal said:
Well, now I'm happy I played as girl Shepard.
" @outlawtotheend: It's certainly arguable as to whether or not Mass Effect starts slowly, but I suspect there may be a more tangible explanation for your dismay. Let me ask you a question: Are you particularly blown away with Mark Meer's interpretation of Commander Shepard? See… I, too, played Mass Effect well after its initial release and--several hours in--felt the same trepidation. Then, for the hell of it, I went back and created a female character. Literally, from that point on, I enjoyed the hell out it. And I'm definitely not alone. In fact, there was a brilliant editorial written on this very subject. I encourage anyone who found themselves unable to enjoy Mass Effect to read it immediately and consider the author's "plea." "
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Wait, no!
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Get off the Citadel and have command of the Normandy and it will get better.
Not true I'm afraid. Mass Effect is really difficult to mod for some reason which was a strange move on Bioware's part (or whoever did the port, they might have had the final decision on mods.)
" Well it actually has a main game story which is more than you can say about ME2. Niether are particularly fun to play. But if you have the PC version, I imagine there are some good mods that make it more manageable. "
Alright, alright, time-out. Can I call a time-out? I'm blowing the whistle.
Does Mass Effect suck?
Who's the TC? You! Yeah, you! Calling you out sir!outlawtotheend? John Marston avatar?! Thinking of dumping this for 100% RDR? You! Come over here!
No! I'm not upset with you! In fact, I'm going to help you out. I want you to do something for me:
I want you to lower your standard, over what classifies as a game "sucking".
Clearly you have not seen or played many games that have truly, sucked. I don't blame you for going after the creme-of-the-crap, but you can't start a meaningful conversation stating a game in absolute terms "sucks", simply because it doesn't gel with you right-off-the-bat.
I'm not talking rough spots of awkwardly combined mechanics, or a beginning that is known by many, to be verrrry slow.
No, I'm talking about the real crap. The type of stuff you can easily, and absolutely state in conversation "sucks" without any eyebrow raising, or confused expressions from your peers.
I love the Mass Effect series (Both games S-Rank), but I most certainly can sympathise with you and those that have trouble getting into the first game. It's slow in the beginning and those that want something that's more traditionally an action game should look somewhere else....like the sequel.
Mass Effect did not suck: It sure has it's laundry list of problems, but it's nowhere near the """quality""" of other fine pieces of software you can play on your 360.
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I assume you have not played ME2 yet -- that would have been stupid if you have not played the original. Anyways, my first playthrough of ME1 was on a piece of shit laptop and I ran the game horribly and didn't enjoy the game nor the graphics I was stuck with. Well, I'm here to tell you, even though the graphics sucked because of my laptop I still completed the game and had a great time doing so. It just takes a little while to get into that Mass Effect vibe, but once you get in, it feel gooood. But I have to say though, I'm far more "negative" towards Mass Effect than most dudes, but still, they're good games and worth going through
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The first Mass Effect was a real love/hate game that rode solely on if you became engaged in the story. The Mako segments, bland indoor settings (away from the Citadel), the ramshackle menu system, bugs and slowdowns were quite prevalent throughout the adventure
There were a lot of gameplay issues that would turn off a lot of people if they did not want to know what would happen next. A game similar to that out recently would be Alpha Protocol. If the espionage story does not grab you, the game's issues will not keel you interested.
Mass Effect 2, on the other hand, is a damn great game all around. The story is much more engaging, the gameplay was streamlined, and the issues were much more rare.
Mass Effect is legit. It amazes me how some games get praised for shittyness (crackdown, fallout) yet everyone dwells on ME bugs like they're killing children. I played through the game twice and the only problem/bug I had was the Mako gettting stuck on a wall, and this only happened once (oh and popin.) The Mako isn't even that bad, its subjective, people don't like the limited aim so the game is bad? wtf. Story is one of the best, you just have to finish the game to get it all. Gameplay is good, menus were good, the wheel is used in all bioware games now so shit on that and you're shitting on console Dragon Age (also an amazing game.) Just play it, ignore all the bitching and i'm sure you'l' love it.
I enjoyed it from the beginning. I actually prefer the first to the second in many respects, I missed all the armour weapon variety/customisation from the first. The second was still amazing thought. It is certainly a game where I can see why people don't get into it. I did find the second play through of Mass Effect 1 more enjoyable by continuing my first character and being more powerful from the start, but that is a commitment if you are not feeling it after 4 hours.
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I said it in my review of ME2 and I'll say it here: the first Mass Effect is kind of a technical mess in a lot of ways, but its story and characters are compelling. However, it comes together much better as a game and a cinematic experience in the sequel.
Plus, if you just want to finish ME to get the story and have a character to import, you can do it in under ten hours easy. Put it on casual and just do the missions.
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I actually found Mass Effect 1 to be a very middling experience. ME2 on the other hand is simply outstanding.
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The original Mass Effect has many ups and downs but it's a game worth playing all the same.
I played for another couple of hours this morning and it's really picked up. I've now played for a little over six hours and the games got a lot more interesting in those couple of hours.
I've got to grips with managing my squad, updating my character etc. and I think now I understand how to play the game properly I'm enjoying it a lot more.
Also, thanks for the huge amount of comments that I got in such a short amount of time.
I played for another couple of hours this morning and it's really picked up. I've now played for a little over six hours and the games got a lot more interesting in those couple of hours.
I've got to grips with managing my squad, updating my character etc. and I think now I understand how to play the game properly I'm enjoying it a lot more.
Also, thanks for the huge amount of comments that I got in such a short amount of time.
I actually really enjoy the dialogue system, It's the gameplay I had trouble getting into
I was late to the party as well but i just beat the game and i enjoyed it. My only complaints were the bugs(sometimes my ai partners were either retarded or just stood there staring at the enemy while i did all the work, or my favorite glitch, if my weapon overheated it would stay permanently overheated until i left the planet.) Oh and the item system was kinda of annoying to work through, by the end of the game i had 800 different pieces of armor and ammo upgrades i never used, a shitload of weapons that were downgrades and already had max money from selling all the crap, just thought they coulda had less random items everywhere and more upgrades. Also Male Shepard voice acting was terrible.
Other than that though it was a good game, im motivated to play the next one and bang the hell out of tali!
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I would'nt personally say it sucks. I just disliked them.
Topic resolved. Finished the game today and loved it.
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Quite the contrary actually.
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Dude, you'll fucking love ME2. Better in EVERY CONCEIVABLE WAY than ME1. It's a fucking badassed game.
" Topic resolved. Finished the game today and loved it. "
I found that once you got off the Citadel it kind of gets weird. I mean, there was something about the Citadel that made me want to just hang out there, though there was nothing to really do there. Once I left the Citadel, I felt a little bit weird (like a man floating out in space). There was much to do, but I didn't have a good point of reference, I kept getting quests over the intercom and I had no idea where I was really going. So my first play through I just stuck as closely to the main story as I could while only going exploring when I felt a little tired of pushing the story further.
If you only play through the story, you will probably enjoy the game. There is a lot of mundane, monotonous side quests that have no effect on the story and are really just there to provide the player with something to do outside of the main story. The mineral/gases collecting is pretty useless in Mass Effect. So if you hate driving the Mako, you're going to hate collecting that shit. My second playthrough I did everything in the game and by the end of it I hated myself for doing it. The mineral collecting is kind of like collecting all the flags in Assassin's Creed, only worse, because it's all over the galaxy.
Even in ME2, searching for minerals is fucking stupid. Why don't they just drop it. I understand they want to add the farming feeling to the game, but it's just too much. In ME2, they streamlined the inventory and leveling parts of the game that it just didn't feel like an RPG in that sense. I would have preferred if they refined the inventory system with categories and such, and given out exp at the end of fights, not missions. Couldn't we just find minerals at the ends of quests or something? That would have made for a lot more reason to play the side quests and at the same time not bore us all with scanning and probing random planets.
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I started this yesterday and I disagree. This game is jizztastic.
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I don't know, I was totally into it right at the beginning. But it gets better and better as you go along.
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Maybe you have no soul?
The first game features:
- Poor shooting mechanics
- Too much inventory disorganization
- Crazy amounts of frame rate drops with or without the film grain on
- The Mako portions
There's just a lot about that game that I didn't like. I was actually afraid to play Mass Effect 2 in the fears that those things wouldn't be fixed well. Mass Effect 2...fixes ALL of that...and then some. That game is fucking great.
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I've never really cared for it.
Mass Effect didn't grab me at first. I had it sitting in a drawer for ages after playing it for a little while and thinking it wasn't much chop. Then I dusted it off and plowed through it and loved it. I'm not saying this is what's going to happen for you, but I found once you push past the initial stages of the game it opens out and becomes really engrossing.
Again, guys, there's no need to keep commenting on this. I finished a couple of days ago and I ended up really enjoying it, as I said in one of my earlier comments.
The topic has been resolved, Mass Effect does NOT suck.
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It took me about four SECONDS to get drawn in.
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About halfway through the game and i'm enjoying it TREMENDOUSLY. Love the characters, love the setting, love the missions, love the squad mechanics. My only qualm so far is the infrequent autosaves and that goddamn vehicle handling.
Yeah, it took me until I was almost halfway through to really get drawn in.
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Mass Effect 2 is waaaaaay better than Mass Effect 1.
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Are you really questioning the game? Big RPG games are always really slow, i don't blame you, i got that way myself at the start, once i was out of Citadel, man the game got amazing and soon after i played ME1 i had to buy ME2 i could not wait to keep playing, i finish ME2 last week :( but there is no way i can buy ME3 is not even out!
The game is awesome in my books :)
For god's sake, guys.
I ALREADY settled this freaking debate in an earlier comment. I was slow to get into it but after a while it grew on me and I really liked it. The gameplay might have been it's weakest point but the dialogue system and depth to the game. My only real problem with it was that you can't go and play the rest of the side missions and DLC without starting over or loading an earlier save.
Ok. So really, no more comments here, yeah? I'd probably delete the blog but I'd like to show off the 94 comments lol.
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"I fucking hate it and want to kill it and every developer at BioWare with a chainsaw. My biggest problem was that I played it for about 5-6 hours, and half of that was me being lost in the Citadel (or anywhere for that matter,) and the rest was me being completely confused as to where to go with only the thought of, "If these guys are shooting me, I guess I'm in the right place." "
Dear god,you took the words out of my mouth.
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text:
This inspiring young entrepreneur Roy Prem Ashok Daniel grew his business
from 1 employee to 20. He is the proud owner of Roy Tailors at Mahabage who's
specialized in wedding suits for men. Two sewing machines, one employee, tiny
space at his own house located in Ragama, and the cutting table used by his
father who too was a tailor, that was all Roy had when he started his business
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As a result of this growth Roy has invested in new machinery, as well as
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Roy tailoring and textile's situated at No:647, Negombo Road, Mahabage though
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Bride & Groom
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Until now, DMX had never known what it was like to finish second with a new LP.
The gravel-voiced, traffic-infraction-prone New York rapper's five previous studio discs all debuted at #1 on Billboard's albums chart. It's Dark and Hell Is Hot opened atop the chart in 1998 after selling more than 251,000 copies, while Flesh of My Flesh, Blood of My Blood, released that same year, crushed the competition with 670,000 sales.
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But the streak ends here. X's latest LP, Year of the Dog, Again just couldn't top the collective might of Rihanna, Chris Brown, Nick Lachey, Kelly Clarkson and more than a dozen other hitmakers — all of whom can be found on Now That's What I Call Music! 22, which takes #1 for a third time, selling 127,000 copies after slipping to #2 on the previous chart.
DMX didn't go quietly. Week-one sales of Year of the Dog, Again were reported at just fewer than 126,000 — putting X only 1,500 copies behind Now 22 — to score the rapper a second-place ribbon.
There's one silver lining to DMX ending his run at the hands of Now 22: He didn't lose out to a bunch of pint-sized singers. Kidz Bop 10 — featuring the Kidz Bop Kids' versions of Daniel Powter's "Bad Day," the All-American Rejects' "Move Along," and Rihanna's "S.O.S." — sold more than 116,000 copies its first week in stores to secure the #3 spot. Following at #4 is Stone Sour's Come What(ever) May — the first studio release in four years from the rock collective featuring members of Slipknot — which racked up close to 81,000 sales.
Previous chart champ LeToya suffered a second-week slump, as her self-titled debut took a 61 percent sales hit and posted just 65,000 scans to land at #5. Tom Petty's Highway Companion follows at #6 with 57,000 copies sold its second week in stores, and Gnarls Barkley's St. Elsewhere finishes at #7 with 53,000 scans.
Five for Fighting's Two Lights opens at #8 with 52,000 units sold, while Pharrell's In My Mind slides seven spots to #9 with week-two sales of 51,000. Nickelback's All the Right Reasons, which has steadily climbed the chart in recent weeks, jumps two spots to #10 after racking up 44,000 scans its 44th week in stores. And after spending 24 consecutive weeks in the top 10, the soundtrack to the Disney Channel original movie "High School Musical" slips to #11.
Panic! at the Disco will be celebrating this week — and not just because of their five MTV Video Music Awards nominations. After 34 weeks on the chart, the band's A Fever You Can't Sweat Out has surpassed the 1 million sold mark, moving more than 35,000 copies to land at #17 on the latest chart.
Lemonade, the latest from G. Love (who've shed the "& Special Sauce" part of their moniker) is the fifth of 10 new releases to crack the top 200, selling 19,000 units to debut at #39. The Pink Spiders open at #84 with their second outing, Teenage Graffiti, which sold 11,000 copies its first week out. Steely Dan's The Definitive Collection bows at #92 with 10,000 scans, followed at #121 by Powerman 5000's Destroy What You Enjoy with 7,000 copies sold.
Jeannie Ortega's No Place Like Bklyn opens at #128 with close to 7,000 sales, and Kill Hannah's Until There's Nothing Left of Us takes #179 with sales nearing 5,000. Christian-minded post-hardcore outfit Showbread's Age of Reptiles just makes the top 200 cut, debuting at #199 with 4,000 scans.


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Secret Garden | Art Walk Experience
- Music
- 318 NW 23rd Street, Wynwood, FL, 33127, US
UHack - University of Miami Hackathon
IEEE University of Miami
Saturday, February 23, 2013 at 11:00 AM - Sunday, February 24, 2013 at 5:00 PM (EST)
The University of Miami IEEE and ACM would like to bring you UHack, a 24-hour hackathon (app creation event). UHack will take place at the end of Miami Tech Week, Saturday February 23rd, and finish the next day, Sunday February 24th. Taking place at the University of Miami, we are open to any student from any educational institution who would like to win great prizes and take some time off their semester by making something fun and possibly win some great prizes from our amazing sponsors. All for free!
This year, we are embracing ART as a central theme for the apps designed this weekend. And by art, we mean all types of art and its interpretations. Want to make the instagram of music, or the Spotify of Images, or have you been thinking of something really cool with videos? Go ahead. This is your time to work on that side project you've been putting off.
Interested in learning more? Check out our website: http://uhack.us
The University of Miami IEEE fosters the idea of improving the world with advancing technology. We try out new hardware and tinker with Arduinos. We also talk about web development and learn some ways to make websites. More importantly, we care about engineering technology as a whole.
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Let {$x_n$} be a bounded sequence such that every convergent subsequence converges to L. Prove that $\lim_{n\to\infty}(x_n) = L$.
The following is my proof. Please let me know what you think.
Prove by contradiction: (A and $\lnot$B)
Let {$x_n$} be bounded, and every convergent sub-sequence converges to L.
Assume that $$\lim_{x\to\infty}(x_n)\ne L$$
Then there exists an epsilon such that |$x_n$ - L|$\ge$ $\epsilon$ for infinitely many n.
Now, there exists a sub-sequence {$x_{n_{k}}$} such that |$x_{n_{k}}$ - L|$\ge\epsilon$.
By Bolzano-Weierstrass Theorem $x{_{n{_k}}}$ has a convergent subsequence $x_{n_{k{_{l}}}}$ that does not converge to L.
$x_{n_{k_{l}}}$ is also a sub-sequence of the original sequence $x_n$, then this is a contradiction since every convergent sub-sequence of xn converges to L.
Hence the assumption is wrong. So $\lim_{n\to\infty}(x_n) = L$


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516-518 East Duffy Street
Savannah, Georgia, 31401
Commute to Downtown Savannah
Most errands can be accomplished on foot.
Flat as a pancake, excellent bike lanes.
Score Details
516-518 East Duffy Street has a Walk Score of 81 out of 100. This location is Very Walkable so most errands can be accomplished on foot.
This location is in Savannah. Nearby parks include Savannah Victorian Historic District, Forsyth Park and Whitefield Square.
Explore how far you can travel by car, bus, bike and foot from 516-518 East Duffy Street.
View all Savannah apartments on a map.
Popular apartment searches include fireplace, pool and hardwood floor.
This location is in the city of Savannah, GA. Savannah has an average Walk Score of 41 and has 136,286 residents.


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Lyndon Poskitt Racing - A blue print for Dakar 2013 - and he did it!
View Single Post
Joined: Jun 2012
Location: Anywhere
Oddometer: 11
Sad news.....:-(
Stage 7 - Special release
Death of the rider Thomas Bourgin
Motorcycle rider no. 106 Thomas Bourgin (FRA) was the victim of a fatal traffic accident on the link route as he made his way to the start of the day's special stage.
The accident took place at 08.23 hours local time on the link route on the way up to the Chilean side of the mountain range. The 25-year-old rider collided with a Chilean police car that was travelling in the opposite direction. The exact circumstances of the accident are being subjected to an inquiry.
The rally's medical teams deployed on the ground were only able to certify the rider's death, probably instant.
Thomas Bourgin, from Saint Etienne, where he was born on December 23rd 1987, was in 68th place in the overall ranking of his first Dakar. He had realised his passion since 2009 when he took part in the Morocco Rally, followed by a 4th place in the 2011 Africa Race and a 7th place finish in the Tunisia Rally.
The organisers of the Dakar and everyone involved in it express their great sadness to his family and friends and offer their most sincere condolences.
The only limit is the one you set yourself.
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Odd that the desert and arctic are so close.
Perisno is a total conversion slight fantasy mod based in the fictional land of Perisno. Only you can get a feel for what it is really like, we can't do it for you. Battle nasty minor factions, encounter unexpected events, and discover unique opportunities! Enter... and you may never return.
Odd that the desert and arctic are so close.
Not really... it's Perisno. Nothing is really odd ;)
Well this view doesn't show any trees at all. Not my fault really, that just happens when I zoom that far out on Thorgrims. :)
This actually looks really really good from that view.
Not that it looks bad from another view. :P


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On April 7, at 12:53 p.m., a fire alarm at Otter Valley Union High School in Brandon alerted local fire crews to a blaze. Most occupants probably thought it was just another false alarm that the school had been plagued with lately. But it soon became apparent as the school was being evacuated that there was more happening than just an alarm. One of the girls bathrooms on the ground floor was on fire. Unfortunately it was not confined there. The ventilation system at the school enabled the flames to spread to second story bathroom directly above All the staff and students escaped the building safely, and volunteer firefighters from Brandon and Pittsford arrived to battle the blaze. They quickly extinguished the fire, and began ventilating the building. The damage, according to a press release by Sergeant James Cruise of the Vermont State Police Fire Investigation Unit, was moderate with both direct fire damage and extensive smoke damage to a large section of the school. According to local officials the ground story bathroom was completely destroyed. The incident was investigated by Police Detective Cruise, Investigator Patterson of the Division of Fire Safety and officers from the Brandon Police Department. It was quickly determined that the fire was intentionally set, though officials have not commented on how the fire started, or if they had any suspects. Officials informed members of the Otter Valley school board that they want to get to the bottom of this quickly, because if this fire had gone any longer undetected it could have spread through the entire school, causing much more damage, including the loss of lives. Current damage is expected to cost hundreds of thousands of dollars to repair. Anyone with any information on the fire is asked to contact Sergeant Cruise at 773-9101, or the Brandon Police Department at 247-5723. You can also contact the Vermont Arson Tip Award Program at 1-800-32-ARSON.
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The Covenant of Grace
Scripture often depicts the Lord as One who is slow to anger and patient with sinners (Ex. 34:6). The fact that He did not destroy Adam and Eve right away after they sinned in Eden is perhaps the best ...Read More
The Deception of Empty Words
There are men and women struggling with sexual sin in all of our congregations. They want to please God and are seeking to mortify the flesh, and we should do all that we can to help them. This means creating ...Read More
The Drama of Redemption
Today's passage contains the beautiful imagery of justice and peace (or mercy, as other translations put it) kissing each other. Our Father graciously restores peace between Himself and us in Christ Jesus. This peace is permanent, for it is ...Read More
The Echo of Conscience
If God has given all people a conscience, why is there so much moral decay in our society (Rom. 1)? What role does the church play in restraining sin (Matt. 1)? What role does the individual Christian play? During the ...Read More
The Fear of Men
The fear of men is perhaps the strongest obstacle to doing the will of God faithfully. Whether we fear what men will say about us or what they will do to us, we are prone to act on that fear ...Read More
The Flesh
Learning to love the things God loves is essential to the mortification of our flesh. Aside from studying Scripture by ourselves, small-group Bible studies and accountability relationships between members of the same sex are powerful weapons in our spiritual warfare ...Read More
The Foolishness of Idolatry
Every form of idolatry manifests our doubts that God really has the ability to save. Counselors have long understood, for instance, that one of the main reasons people become drug, alcohol, and sex addicts is because they are looking for ...Read More
The Justice of God's Choice
We must take our standards for justice from what God says and not from our own arbitrary opinions. If God says something is just, it is just. Of course, the Lord is not arbitrary about this. Justice is grounded in ...Read More
The Just Mercy of the Lord
God does not visit the sins of our parents upon us if we repent and turn from them. That is, we only bear the wages of our parents' sins if we make these sins our own. The Lord is pleased ...Read More
The Law of the Mind vs. the Law of Sin
Though we have changed hearts if we truly believe in Christ, that does not mean we are not thoroughly affected by sin. Our minds, emotions, bodies, and everything else are tainted by our flesh—the fallenness that God does not ...Read More
The Mouths of Sinners
The degradation of a culture is clearly seen in the kind of language it tolerates about other people and even about God Himself. We are living in a society that is increasingly vulgar and whose corruption threatens even those who ...Read More
The Necessity of the Cross
The modern church's emphasis on God's love at the expense of His other attributes has led many of us to forget that God's justice was a primary motivating factor for the Cross. But if we forget God ...Read More
The Need for Atonement
In other religions, such as Islam and Judaism, God simply waves sin away, not requiring payment for transgressions in order to forgive. This idea betrays a view of a Creator who is not really all that holy, who ultimately is ...Read More
The Practical Syllogism
Take the one area in your life that you selected yesterday and apply the practical syllogism. Once again, look up passages that deal with this subject. Use these verses to write the first premise. Then prayerfully examine your own life ...Read More
The Primal Sin of Humanity
Douglas J. Moo writes in his commentary on Romans, "At the very center of every person, where the knowledge of God, if it is to have any positive effects, must be embraced, there has settled a darkness—a darkness that ...Read More


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product details-Tab
NOTE: Actual product packaging may differ from image shown due to packaging updates by manufacturer.
Dietary Supplement
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Not intended for use by persons under 18. Do not use if pregnant of nursing. Discontinue use and call a medical doctor if you experience unusual symptoms. Consult a medical doctor before use if you have been treated for, or diagnosed with or have a family history of any medical condition of if you are using any prescription or over-the-counter drug(s), including blood thinners. Do not combine with other sources of yerba mate. Consult a medical doctor before starting a diet or exercise program. Do not exceed recommended serving. Improper use of this product will not improve results and is not advised. Use only as directed. Do not use if packaging has been tampered with. Keep Out of Reach of Children. Contains Soy and Peanut Ingredients.
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Xenadrine has really helped me manage my
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Bottom Line Yes, I would recommend this to a friend
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2 rapid release capsules with a glass of water, 30 minutes before your 3 meals of the day. Use while following a calorie-reduced diet and regular exercise program. Don't snack after dinner or in between meals and remember to drink 8 to 10 glasses of water each day. For best results, use Xenadrine® for 8 to 12 weeks. Do not exceed 6 capsules in a 24 hour period. Do not take within 5 hours of bedtime. Ensure you read the entire label before use and follow these directions.


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Explore the Entrepreneurship.org Resource Center to find resources. Designed with entrepreneurs in mind, our resource center allows you to find materials to grow great ideas.
This topic expert provides a step-by-step process for understanding a sales reps' potential for results, their motivation factors, and developing a comp plan that fits those characteristics. Strategy, combined with communication, can help sales reps meet their goals and their companies' profit goals.
Rather than viewing compensation plans as a motivational tool, this entrepreneur believes they should be considered a means for managing risk and protecting the company's cash assets. He explains his firm's model, which is based on transferring more risk to sales associates, sharing resources across clients, and tying a portion of base salary to reaching certain revenue-related milestones.
Going global takes guts, the author asserts. You have to confront the unknown and make it look easy when it's not.
Giving back to the community-and engaging one-on-one with charitable operatives, the press, and other local constituencies-enables small businesses to increase exposure at little cost, says the founder of a national moving franchiser.
Global growth is essential for entrepreneurial companies but must be managed to overcome challenges such as language barriers and tax-related paperwork, says the founder of a Harley-Davidson licensee.
Attention-grabbing tactics for niche products include providing snappy names and packaging, placing cold calls, and befriending the media in an effort to win PR, says the founder of a specialty women's hosiery company.
When developing a strategic plan to launch an international business program, growing companies must consider the potential barriers and adjustments they might need to make to their products and services.
Tactics for selling services are offered by an entrepreneur whose consulting firm places temporary senior-level talent in finance, law, and other disciplines in early-stage and growth companies.
Distributors, sales representatives, and cooperatives are all different venues for enabling entrepreneurial companies to sell their products and services. Understand the similarities and differences, and chose the alternative that is right for your business.
An entrepreneurial company just past the start up stage faces the issue of how to find customers for its product or service, price it right and get the word out, writes the founder of a software company and also a previous business. Meeting the challenges of phase two sets the stage for substantial growth, the author says.
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Originally written on Fox Sports | Last updated 3/9/13
D'Andre Wright scored 15 points, James Woodard had a double-double and Tulsa withstood a late rally by Rice to defeat the Owls 77-71 on Saturday night. Tulsa (16-14, 8-8 C-USA) held a 73-60 lead with 2:26 remaining in the game but Julian DeBose capped an 11-2 run by the Owls with a three-point play to make it 75-71 with 27 seconds to go. DeBose ended his night with 17 points and five rebounds. Rice's comeback fell short however with a turnover and two missed 3-pointers and the Golden Hurricane were able to hold on for the win. In the first half, Scottie Haralson sparked a 15-2 run for Tulsa in the first 7 minutes of play thanks to back-to-back 3-pointers and scoring 11 of his 15 points. Tamir Jackson scored 30 points, grabbed seven rebounds and had five assists for Rice (5-25, 1-15).
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Originally written on RedSoxLife | Last updated 6/23/13
Jim Monaghan Contributing writer You know the circumstantces by now - bottom of the eighth inning in a 4-4 game. Shane Victorino had come out of the game with what Red Sox manager John Farrell would describe as "general soreness...general tightness." Daniel Nava was now in right field heading back toward the fence on a fly ball by Avisail Garcia. Nava appeared to catch the ball for an out, and then drop the ball on the transfer to his throwing hand (pictured). Click here to see the video. Second base umpire Mike DiMuro had a different opinion, saying that there was no catch. Nava and Farrell argued in vain; Farrell, in fact, was thrown out of the game for the first time this season. After the game, umpire crew chief Ted Barrett defended the call. "To have a catch, you have to have complete control and voluntary release," he said. "[DiMuro] had him with control, but did not have the voluntary release. When he flipped the ball out of his glove, he never got it into his ...
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In order to try and keep our web presence afloat during Friday and Saturday nights during the high school football season, ScoringLive came up with the concept of a 'lite' version of our website.
Our traffic patterns dictated that the majority of users coming during game nights were after mainly current scores and stats, so we developed a special framework that we hope will be able to deliver the most sought after content with little to no interruption in service.
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Mater Dei outscored the Hawaii Raiders, 31-18 in the second half to pull away in a summer league game...
Kurt Miyahara and Dean Yonamine take helms of baseball and softball programs, respectively.
Selected photos from the annual awards banquet of the Oahu Interscholastic Association held at the Ala...
Crusaders' junior QB Tua Tagovailoa named second winner of annual Newcomer Award.
Senior-to-be quarterback McKenzie Milton led Mililani to its first Division I state football crown with...
Konawaena's Chanelle Molina led the Wildcats to their second straight volleyball state championship in...
For the 10th consecutive year, HMSA recognizes the efforts of student-athletes both on and off the field...
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Visit the atrium for the LIVE WELL BE WELL Fair. Pet the therapy dogs, get a massage, work with a trainer or nutritionist, have your blood pressure checked and enjoy other opportunities to reduce stress and promote a healthier you. Lots of food, prizes and fun!
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"From coast to coast, universities that brim with liberal ideas and idealistic students won't be sending nearly as many voters to the polls on Nov. 2. And that's bad news for Democrats."
What I said.
The NY Times' Nate Silver took the Politico data and crunched the numbers to come up with this summary:
"So, what do we see? We see good news for Republicans - although not necessarily better news for them than is already implied by the polling."
The polling to which Silver refers has the GOP generic vote, according to RealClearPolitics.com at an average of +7.7 percent which includes a Newsweek poll showing Democrats ahead by three.
In fact, RCP predicts that if the election were held today the GOP would end up with 222 seats (218 needed for a majority), the Dems would have 177 seats with 36 still rated as toss-ups.
Even if Republicans were to lose all of the toss-up seats they would still win the majority. However, of those 36 toss-ups, 34 are currently held by Democrats meaning every toss-up won by a Republican is another two-seat swing in the House.
Republicans may not win them all, but they have the ball deep in the Democrats' end of the field.


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