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Are you Yu-Cheng Tseng?Claim your profile
Publications (8)56.87 Total impact
- SourceAvailable from: Yih-Chih Hsu
Article: Nanoparticle delivery of HIF1α siRNA combined with photodynamic therapy as a potential treatment strategy for head-and-neck cancer[Show abstract] [Hide abstract]
ABSTRACT: Combination therapy has become a major strategy in cancer treatment. We used anisamide-targeted lipid-calcium-phosphate (LCP) nanoparticles to efficiently deliver HIF1α siRNA to the cytoplasm of sigma receptor-expressing SCC4 and SAS cells that were also subjected to photodynamic therapy (PDT). HIF1α siRNA nanoparticles effectively reduced HIF1α expression, increased cell death, and significantly inhibited cell growth following photosan-mediated photodynamic therapy in cultured cells. Intravenous injection of the same nanoparticles into human SCC4 or SAS xenografted mice likewise resulted in concentrated siRNA accumulation and reduced HIF1α expression in tumor tissues. When combined with photodynamic therapy, HIF1α siRNA nanoparticles enhanced the regression in tumor size resulting in a ~40% decrease in volume after 10 days. Combination therapy was found to be substantially more effective than either HIF1α siRNA or photodynamic therapy alone. Results from caspase-3, TUNEL, and CD31 marker studies support this conclusion. Our results show the potential use of LCP nanoparticles for efficient delivery of HIF1α siRNA into tumors as part of combination therapy along with PDT in the treatment of oral squamous cell carcinoma. Copyright © 2014. Published by Elsevier Ireland Ltd.Cancer Letters 01/2015; 359(1). DOI:10.1016/j.canlet.2014.12.052 · 5.02 Impact Factor
Article: Lipid-calcium phosphate nanoparticles for delivery to the lymphatic system and SPECT/CT imaging of lymph node metastases.[Show abstract] [Hide abstract]
ABSTRACT: A lipid/calcium/phosphate (LCP) nanoparticle (NP) formulation (particle diameter ∼25 nm) with superior siRNA delivery efficiency was developed and reported previously. Here, we describe the successful formulation of (111)In into LCP for SPECT/CT imaging. Imaging and biodistribution studies showed that, polyethylene glycol grafted (111)In-LCP preferentially accumulated in the lymph nodes at ∼70% ID/g in both C57BL/6 and nude mice when the improved surface coating method was used. Both the liver and spleen accumulated only ∼25% ID/g. Larger LCP (diameter ∼67 nm) was less lymphotropic. These results indicate that 25 nm LCP was able to penetrate into tissues, enter the lymphatic system, and accumulate in the lymph nodes via lymphatic drainage due to 1) small size, 2) a well-PEGylated lipid surface, and 3) a slightly negative surface charge. The capability of intravenously injected (111)In-LCP to visualize an enlarged, tumor-loaded sentinel lymph node was demonstrated using a 4T1 breast cancer lymph node metastasis model. Systemic gene delivery to the lymph nodes after IV injection was demonstrated by the expression of red fluorescent protein cDNA. The potential of using LCP for lymphatic drug delivery is discussed.Biomaterials 03/2014; DOI:10.1016/j.biomaterials.2014.02.030 · 8.31 Impact Factor
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ABSTRACT: To address the question of how cells respond to the possible Ca2+ toxicity caused by the release of Ca2+ into the cytoplasm by LCP nanoparticles , a series of in vitro and in vivo studies using Ca2+ pump inhibitors were conducted. The results indicated that two major Ca2+ pumps on the plasma membrane and the mitochondrial membrane, respectively, were able to rapidly respond to the elevated cytosolic Ca2+ concentration and prevent Ca2+-induced apoptosis or necrosis. However, exposure to specific inhibitors of calcium pumps would cause LCP-treated H460 cells to undergo necrosis both in vitro and in vivo. These results demonstrated that the Ca2+ delivered by LCP was not toxic to cells when the cells contain functional Ca2+ pumps.Molecular Pharmaceutics 09/2013; 10(11). DOI:10.1021/mp400028m · 4.79 Impact Factor
Article: Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis[Show abstract] [Hide abstract]
ABSTRACT: Immunotherapy has shown the potential to become an essential component of the successful treatment of various malignancies. In many cases, such as in melanoma, however, induction of a potent and specific T-cell response against the endogenous antigen or self-antigen still remains a major challenge. To induce a potent MHC I-restricted cytotoxic T-lymphocyte (CTL) response, cytosol delivery of an exogenous antigen into dendritic cells is preferred, if not required. Lipid-Calcium-Phosphate (LCP) nanoparticles represent a new class of intracellular delivery systems for impermeable drugs. We are interested in exploring the potential of LCP NPs for use as a peptide vaccine delivery system for cancer therapy. To increase the encapsulation of Trp2 peptide into the calcium phosphate precipitate core of LCP, two phosphor-serine residues were added to the N-terminal of the peptide (p-Trp2). CpG ODN was also co-encapsulated with p-Trp2 as an adjuvant. The NPs were further modified with mannose to enhance and prolong the cargo deposit into the lymph nodes (LNs), which ensured persistent antigen loading and stimulation. Compared with free Trp2 peptide/CpG, vaccination with LCP encapsulating p-Trp2 and CpG resulted in superior inhibition of tumor growth in both B16F10 subcutaneous and lung metastasis models. An IFN-γ production assay and in vivo CTL response study revealed that the improved efficacy was a result of a Trp2-specific immune response. Thus, encapsulation of phospho-peptide antigens into LCP may be a promising strategy for enhancing the immunogenicity of poorly immunogenic self-antigens for cancer therapy.Journal of Controlled Release 09/2013; 172(1). DOI:10.1016/j.jconrel.2013.08.021 · 7.26 Impact Factor
Article: Biodistribution Studies of Nanoparticles Using Fluorescence Imaging: A Qualitative or Quantitative Method?[Show abstract] [Hide abstract]
ABSTRACT: PURPOSE: The biodistribution of Lipid/Calcium/Phosphate (LCP) nanoparticles (NPs) in tumor-bearing mice was investigated using fluorescence imaging. A quantitative validation of this method was done by (3)H and (111)In labeling of the nanoparticles. METHODS: The biodistribution of LCP NPs containing oligonucleotides was investigated using three different probes: Texas-Red labeled oligonucleotides, (3)H-labeled oligonucleotides, and (111)In-labled calcium phosphate. RESULTS: A discrepancy was found between the radioactivity and the fluorescence signals. Signals from (3)H and (111)In exhibited very similar distribution patterns, suggesting that liver and spleen were the major accumulation sites. However, fluorescence imaging indicated that tumor accumulation was predominant. We further confirmed that the fluorescence signals in both liver and spleen were greatly attenuated compared with those in the tumor due to the intrinsic tissue absorption and scattering. Near-infrared (NIR) dye Cy5.5 also suffered from the same problem, in that the quantitative data from whole organs was dramatically affected by absorption and scattering properties of the tissue. CONCLUSIONS: Careful attention must be paid to the quantification and interpretation of fluorescence imaging measurements when comparing different tissues.Pharmaceutical Research 07/2012; DOI:10.1007/s11095-012-0818-1 · 3.95 Impact Factor
Article: Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery.[Show abstract] [Hide abstract]
ABSTRACT: A lipid coated calcium phosphate (LCP) nanoparticle (NP) formulation was developed for efficient delivery of small interfering RNA (siRNA) to a xenograft tumor model by intravenous administration. Based on the previous formulation, liposome-polycation-DNA (LPD), which was a DNA-protamine complex wrapped by cationic liposome followed by post-insertion of PEG, LCP was similar to LPD NP except that the core was replaced by a biodegradable nano-sized calcium phosphate precipitate prepared by using water-in-oil micro-emulsions in which siRNA was entrapped. We hypothesized that after entering the cells, LCP would de-assemble at low pH in the endosome, which would cause endosome swelling and bursting to release the entrapped siRNA. Such a mechanism was demonstrated by the increase of intracellular Ca(2+) concentration as shown by using a calcium specific dye Fura-2. The LCP NP was further modified by post-insertion of polyethylene glycol (PEG) with or without anisamide, a sigma-1 receptor ligand for systemic administration. Luciferase siRNA was used to evaluate the gene silencing effect in H-460 cells which were stably transduced with a luciferase gene. The anisamide modified LCP NP silenced about 70% and 50% of luciferase activity for the tumor cells in culture and those grown in a xenograft model, respectively. The untargeted NP showed a very low silencing effect. The new formulation improved the in vitro silencing effect 3-4 folds compared to the previous LPD formulation, but had a negligible immunotoxicity.Journal of Controlled Release 11/2009; 142(3):416-21. DOI:10.1016/j.jconrel.2009.11.008 · 7.26 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Lipid-based nanoparticle technology has developed from chemical drug carrier into an efficient multifunctional siRNA tumor targeting delivery system. In this review, we start with an overview of the lipid-based nanomedicine history and the two classes of lipidic vectors for DNA or siRNA delivery. Then we discuss the features of lipid-based nanomedicine that lead to effective tumor targeting and the principles behind. We also discuss nanoparticle surface modification, classes of tumor targeting ligands, and other state-of-the-art strategies for enhancing endosome release primarily focused on lipid-based systems. At the end, we show that multifunctional self-assembled lipid-based nanoparticles could also be versatile delivery vehicles for cancer molecular imaging probes.Journal of Biomedical Nanotechnology 08/2009; 5(4):351-63. DOI:10.1166/jbn.2009.1044 · 7.58 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: RNAi technology has brought a new category of treatments for various diseases including genetic diseases, viral diseases, and cancer. Despite the great versatility of RNAi that can down regulate almost any protein in the cells, the delicate and precise machinery used for silencing is the same. The major challenge indeed for RNAi-based therapy is the delivery system. In this review, we start with the uniqueness and mechanism of RNAi machinery and the utility of RNAi in therapeutics. Then we discuss the challenges in systemic siRNA delivery by dividing them into two categories-kinetic and physical barriers. At the end, we discuss different strategies to overcome these barriers, especially focusing on the step of endosome escape. Toxicity issues and current successful examples for lipid-based delivery are also included in the review.Advanced drug delivery reviews 04/2009; 61(9):721-31. DOI:10.1016/j.addr.2009.03.003 · 12.71 Impact Factor
Top Journals
University of North Carolina at Chapel Hill
North Carolina, United States
- Division of Molecular Pharmaceutics


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Location is great and it is adequate. There is very little to choose from in Fulton, MO, and I will stay here again because of the location and the reasonable price.
For just a little attention, this could be a much nicer property. Curtains were hanging off the hooks; lapshades lop-sided; just needs some TLC.
It was clean.
It's seems like it's in the middle of nowhere. The decor was very blah for a Holiday Inn Express.
I liked the convenience, the friendliness of the staff and the cleanliness of the hotel. I also liked the fact that they had an indoor pool.
It was so clean!! Even the bathroom floor corners were clean.We liked the location, it was very quite. The staff was very helpful and pleasant.
It was set back, out of the way--great location
Bathroom could have been a little bit cleaner--
Convenient location
I stayed at this property six months ago and the pool was out of service - it still is! Exterior key card security doors do not work; TV's need upgrading - not even a flat screen! Continental Breakfast could be both improved and presented better. It was also a little irritating to see a rate posted on the outside neon sign the last night (of my 2 night stay) that was less than what I was paying per night!
Liked the location. All we wanted was one night stay and nothing else. If I was going to spend more than one night there I might have had a complaint or two. It was what we needed and where we needed.
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In the revision, the authors describe those mathematical methods that, based on the evolution of pairs of proteins, are capable of predicting molecular interactions at different levels of complexity.
These methods include those approaches from the 1990s that predicted contact points between proteins; those that allow us to understand binding selectivity between very similar proteins -or ones that belong to the same family- and their ligands; or even, at a deeper level of complexity, those that predict interaction networks between the thousands of proteins that make up cells.
Over the last 20 years, Valencia's team has led several lines of research related to this field, many of which are still being studied by many other groups and in which his team continues to be a world leader.
"In 2012, we published a new set of predictions on the specificity of the binding of the Ras oncogene to other proteins. The tool was based on coevolution methods that we had developed a couple of years ago, and that are now being widely explored by other groups," explains Valencia. The Ras protein family is associated with a wide spectrum of cancers, so learning the language it uses with other proteins that are important for cells might open avenues for the development of novel drugs.
The authors of the study foresee a promising future for this field, in which bioinformatics programmers, physicists, biologists and mathematicians join forces in order to describe the complexity of protein dynamics.
"In the long term, we hope that unifying these methods will help us to manipulate or create new drugs that selectively target abnormal cells and therefore reduce side effects," says de Juan.
|Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)


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Hotels in 46974 - Roann IN
Only hotels in 46974 zip code are listed below. Search for cheap and discount hotel rates in Roann, IN for your upcoming leisure or conference / group travel. We list the best 46974 hotels and motels so you can review the Roann hotel list below to find the perfect lodging. Hotels in Wabash county and area code 765 are also listed.
46974 Hotels/Motels & Accommodations
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spinal stenosis can usually be diagnosed based on your
history of symptoms, a
physical exam, and imaging tests—tests that produce various kinds of pictures of your body. These tests include:
Your doctor may try nonsurgical treatment,
such as pain-relieving medicines, exercise, and physical therapy, for a period
of time before ordering imaging tests. If treatment works, you may
not need tests.
Imaging tests can help confirm a diagnosis or rule out other problems. But even if imaging shows spinal stenosis, your symptoms may not match the results of the tests. So treatment is based on what your symptoms are and how much spinal stenosis is impacting your life, not just on the results of imaging tests.
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Tailored with soft shoulders, full lining, and easy drape. Center vent. 100% Wool. Dry Clean. Imported. Internet Only.
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(based on 3 reviews)
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Great jacket for the price.
By Stylish but Classic
from Winston-Salem, North Carolina
About Me Classic, Practical, Stylish
Comments about Jos. A. Bank Executive 2-Button Wool Patterned Sportcoat:
I bought this sport coat on-line. My work environment for the most part is business casual. However, wearing the jacket with a tie and sweater vest creates a nice traditional business look. The color is very similar to what you see on-line. Great purchase for the price.
Bottom Line Yes, I would recommend this to a friend
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Not what I expected
By Len
from FL
About Me Stylish
I thought the quality could be better. It looks a lot better on the web than it does in person. The matarial was thin and did not seem to hang right.
Bottom Line No, I would not recommend this to a friend
Service,Selection&Quality are JOS A BANK
By L.G.
from Kansas city,Ks
About Me Comfort-oriented, Practical, Stylish, Trendy
Like to be dressed right for any and all occasions.
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Interlibrary Loan services are available to all current UTPA students, faculty, and staff for research purposes.
For assistance, please contact:
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34 year old woman | Greenwood, IN, USA | Seeking men 34-45 within 50 miles
Active within 24 hours
Love looks not with the eyes, but with the mind. ~Shakespeare
I am an ambitious, compassionate, generous person who always puts God and family first. I am well educated and looking for a match in this area who can continue to learn new things with me throughout our journey together. I'm looking for a man who has experienced life (education, work, travel, etc.) but now wants to share new experiences with a life-long partner. I would like to share similar morals/values in order to one day raise a family. The best match for me would be successful in his career, has a strong sense of family and friends, is as independent as I am, but also wants to be cared for and loved and who is willing to care for and love his partner. It would be icing on the cake if you like to travel, go to concerts, nice restaurants, and who can be be comfortable chilling at home.
Alumni connections , Book club , Coffee and conversation , Business networking , Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Religion/Spiritual , Travel/Sightseeing , Volunteering , Wine tasting
Baseball, Billiards / Pool, Bowling, Dancing, Football, Golf, Tennis / Racquet sports, Walking / Hiking, Weights / Machines, Yoga
I exercise 1-2 times per week.
I have Cats
Middle of the Road
Anywhere I'm with good company
Having a conversation with someone who challenges and stretches me. Baking and cooking working in the yard reading spending quality time with family and friends learning traveling
For fun: -going to nice restaurants -going to concerts -wine tastings -ballroom dancing -hanging out with family and friends
I am an avid reader, so this list could change constantly. Right now I am reading The Goldfinch.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'3" (160cms)
|5'8" (172cms) to 8'11" (271cms)
|Body type:
|Slender, About average, Athletic and toned
|Blue, Brown, Grey, Green, Hazel
|Dark brown
|Black, Light brown, Dark brown, Salt and pepper, Bald
|No Way
|No Way
|Social Drinker
|Social Drinker
|Nonprofit / Volunteer / Activist
|Executive / Management, Financial / Accounting / Real Estate, Legal, Medical / Dental / Veterinary / Fitness, Political / Govt / Civil Service / Military, Sales / Marketing, Self-Employed / Entrepreneur, Other profession
Director of Development & Communications for an local non-profit social service organization.
|I'll tell you later
|$75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married
|Never Married, Widow / Widower
|Have kids:
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|Definitely, Someday
|White / Caucasian
|White / Caucasian
|Christian / Other
|Christian / Catholic, Christian / LDS, Christian / Protestant, Christian / Other
|Graduate degree
|Bachelors degree, Graduate degree, PhD / Post Doctoral


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54 year old man | Redondo Beach, CA, USA | Seeking women 40-55 within 35 miles
Partner wanted for Fun and Banter
(Update, as of 11-21 I am off the grid until next week. I'll respond asap then) Thanks for dropping by. To start I'll say who I am... Integrity is a big deal. Keeping my word, doing the right thing, and doing what I say - those are my daily goals; My wit is sharp, my humor dry; I am athletic so any kind activity is good except for things like Hatchet tossing (I like the tossing, just not the catching); I really enjoy the old-fashioned stuff: the guy gets her door, buys flowers, writes cool poems, he has dates that are all about her, he comes up with clever surprises, etc. These things are what I constantly strive to be great at; Have my 2 teenage boys half-time (week on, week off). We are tight. I love to watch them play football and soccer. Bonus round: I am a quite the masseur (had some training) and never had an unhappy customer. Note: I have a soft spot for anyone dealing with a special needs child, Autism in particular, as I have personal (and successful) experience with this. I have helped families, usually the Dads, deal with the emotional issues related to raising a special child. For the last 9 years I've served on local committees that directly assist the kids and/or the parents both financially and emotionally. Very rewarding and keeps me grounded! If you know of anyone who needs assistance related to this, have them contact me. . Besides real estate, that other world is my passion. MISC: (1) Family is important. I am very close to my folks see them weekly; (2) Anyone who is overly-judgmental, or a Bible-thumper, or racist - bye bye! (3) I do volunteer frequently for the YMCA and special needs kids clinic, Pediatric Therapy Network. Doing charity work as a couple is, to me, essential. If you are apathetic about charity work, we are not a match. (4) When I'm wrong I admit it. (5) If your profile is great, I'll let you know. I am nicely persistent, not because I am a stalker, but because I go after who seems terrific; If you are not interested, I always appreciate a quick "thanks, but no thanks". (6) No lobster, Limos or Lear jets on the first few dates. My current priorities are my real estate businesses, my charities, and my fam/friends. When I have a committed partner though, she is big life priority. As she supports what's important to me, then there isn't anything I won't do for her. YOU: Sassy with a smile.. Sincerely kind to kids, elders and waiters (I think kindness is VASTLY underrated, by the way)... Low drama w/mature attitude... semi-athletic... Smart.. Can handle a witty, sarcastic, but funny guy (uh, that would be me). Oh, in case you are saying to yourself "Geez, this guy is great! Just wish he was a little taller!" Believe me, I have the same wish!! BUT, look at George Clooney! He's was with a taller lady and no one mocked him! I know, I'm no Clooney... but he probably can't give a rockin' massage like I can! So we're even (except for his Limo and Lear). LASTLY, I BELIEVE: (1) Men and women are very different, and those differences - as we embrace them - make us great, thrilled, influential, happy partners. (2) Every woman (from a Sports Illustrated cover model to a receptionist) is still a Girl inside, a girl who wants to be feel pretty, loved, special, protected and treated like a princess. When I remember that, I am at ease with any woman. (Do I still get butterflies on a date, though? Yep!) (3) A man is nothing if he is not a great father. Anyone who knows me will say I am one of the best fathers they know. (4) Every man (CEO to a ditch-digger) wants 2 things. You know the first one, right?, but the second one is to be Successful. Success is deeply core to a man's being. Support him in that and he'll do anything for you. I know I will. Cheers, Nick
Coffee and conversation , Business networking , Movies/Videos , Museums and art , Exploring new areas , Playing cards , Playing sports , Shopping/Antiques , Travel/Sightseeing , Volunteering , Watching sports , Wine tasting
Basketball, Billiards / Pool, Football, Martial arts, Skiing, Soccer, VolleyBall, Walking / Hiking, Weights / Machines
I exercise 3-4 times per week.
I like Dogs
I like any pet that doesn't lick their privates then try to kiss me.
Middle of the Road
If in Redondo, the Green Temple restaurant for healthy food or Handels Ice Cream for amazing frozen yogurt or chocolate buckeye ice cream. I love the beach/cliffs for runs, walks, hikes. Any museum or art show.
California State University, Long Beach, Long Beach, CA
I really enjoy parties, playing tennis, working out, going out with friends, watching sports (football, basketball, soccer, MMA). I have my 2 teenage boys half-time and we do lots of things together and luckily we are very close and have fun together
I think this is already answered in my main profile text.
I rarely read books. CNN.com is main source of info on the World. I started Fifty shades of grey but kept getting stuck reading the same few pages.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'5" (165cms)
|3'0" (91cms) to 5'6" (167cms)
|Body type:
|Athletic and toned
|Slender, About average, Curvy, Athletic and toned, A few extra pounds, Stocky
|Black, Blue, Brown, Grey, Green, Hazel
|Salt and pepper
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Salt and pepper, Silver, Dark blonde, Grey, Platinum
|No Way
|No Way, Occasionally, Cigar aficionado, Yes, but trying to quit
|Social Drinker
|Never, Social Drinker, Regularly, Moderately
|Financial / Accounting / Real Estate
|No preference
I own a South Bay based Real estate brokerage (homes and income property) and a property management firm.
|$35,001 to $50,000, $50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married, Widow / Widower, Currently Separated, Divorced
|Have kids:
|Yes, and they sometimes live at home (2)
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|No, but it's OK if my partner has kids
|Not sure, Probably not, No, No, but it's OK if my partner has kids
|White / Caucasian
|East Indian, Latino / Hispanic, Middle Eastern, Native American, Pacific Islander, White / Caucasian, Other
My background is quite Greek. If you saw "My Big Fat Greek Wedding" I'll let you in on a little secret... its a DOCUMENTARY! Trust me. Mom has a Greek Food catering business! Want some amazing baklava?? Spanikopita?
|Christian / Other
|Agnostic, Atheist, Buddhist / Taoist, Christian / Catholic, Christian / LDS, Christian / Protestant, Hindu, Jewish, Spiritual but not religious, Other, Christian / Other
Greek Orthodox to be specific.
|Bachelors degree
|High school, Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral
My degree is in construction engineering from Cal State Long Beach. Technically I am an engineer, but my personality is quite outgoing, charismatic, funny, etc.


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Posted November 27, 1995 and updated on June 10, 2015
Why is Free Willy 2: The Adventure Home rated PG?
Official MPAA Rating: Free Willy 2: The Adventure Home is rated PG for for mild language and mild peril
Please read our content details for this movie to help determine if it is suitable for members of your family. We also encourage you to check our full review and our movie information page.


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Times Union Real Estate - Homes for Sale, Apartments for Rent, Open Houses
Find real estate, homes for sale, apartments for rent and commercial properties in Albany, NY and the Capital Region.
Posts filtered on Category
Some kids showed up at Brian Holloway's house. Not the ones accused of trashing it though. A guy who wants to build a big sports complex next to the Memory Gardens cemetery in Colonie is getting some blow back. The Showcase of Homes is this weekend. … [Read More]
Parade of style differences
The range of design and architectural styles in the Parade of Homes this year is fairly dramatic, from the modern-influenced condos at 17 Chapel, to a ranch with Italianate flourishes in Schenectady. Read more about it in my story from Sunday's Real Estate section here. [Read More]
High Rock Condominiums
The highest-priced stop on the Parade of Homes is a condominium. The High Rock Condominiums LLC, a partnership of Bette & Cring, a large local developer of multi-family housing; Turf Hotels, a hotel developer and operator; and investor Frank Parillo, constructed a 123-room Hampton Inn and the adjoining condo building in 2008 and 2009. Half […] [Read More]
8 Aurora Ave., Oak Ridge, Saratoga Springs
Third generation builder Dave DePaulo, owner of Bella Homes, offered 8 Aurora Ave., Oak Ridge in Saratoga Springs for this year's Parade of Homes. The house has 4 bedrooms and 3 1/2 bathrooms inside 3,483 square feet. The model is one of five plans available in the Oak Ridge development off Dyer Switch Road. "The […] [Read More]
884 Lisha Kill Road, Niskayuna
A custom home by Belmonte Builders in Niskayuna is on the Parade of Homes. The 3-bedroom, 3-bathroom, two-story design was inspired by the architecture of the French countryside, according to the builder. Another house built with the ever-popular open … [Read More]


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One frustrating aspect of the National Archives site is that you have no way, in advance of logging into the site and beginning the order process, to know whether they have records from the place and year you are looking for, which means you might spend time going through the login and ordering processes only to find out they don't have records from the year you need.
In an attempt to make this process a little bit easier, I've created a table listing all the States and Cities for which Naturalization records can be ordered from the National Archives, and have listed the ranges of years for which records are available. You can now go to the Naturalization page on this web site to see the complete table of Nationalization record holdings at the National Archives.
Note that each of the general resources I have created on this site now have their own tabs across the top of each page, one each for Forms (the B&F Forms System), Search (B&F Enhanced Genealogy Search) and now Naturalization.
In future I hope to enhance the Naturalization page with other resources specific to accessing Naturalization records. Let me know what you think.


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Marion County Health Department
230 E. Main
Marion, KS 66861
(620) 382-2550
Fax (620) 382-8823
Child health assessments for Preschool, Kindergarten, Daycare and Kan Be Healthy (KBH 0-20 yrs.) are available at the Health Department by apointment.
Medical Cards are accepted. If you have no insurance, a sliding fee scale may be applied based on total household income.
Catch health problems early and treat them before they become more serious! More medical services are available if you are screened for a Kan Be Healthy.
For an appointment, call the Health Department at 620-382-2550.


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We guarantee the authenticity of all items auctioned on this Official Online auction site. We can not guarantee the authenticity of any Fremantle memorabilia auctioned on any other site (i.e. ebay etc).
Any queries can be answered by contacting email@example.com
Select the Register button above to start bidding!
The Fremantle Dockers Online Auction gives members and fans the chance to source unique one off items, experiences and reserved memorabilia numbers normally unavailable to the public. All items are guaranteed as authentic, and the money raised directly benefits the club and its onfield operations.
New and exciting items regularly appear and bidding registration is free.


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The Message audio Bible is now available on Bible Gateway! Click to learn more.
(an opponent), the name of a number of kings of Syria who lived during the interval between the Old and New Testaments, and had frequent connection with the Jews during that period. They are referred to in the Apocrypha especially in the books of the Maccabees.


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The Marion County Historical Society is in the process of finalizing the schedule of events for 2015. These planned events are divided into two categories. The first category, Programs, will be traditional presentations related to the topic at an associated venue. The second category, Walking Tours, will be less formal tours with a short presentation on the historical topic followed by an informal discussion and beverage near the site of the tour.
WHERE: Crispus Attucks Museum (located on the west side of Crispus Attucks Medical Magnet High School, 1140 Dr. Martin Luther King Jr. St., Indianapolis, IN).
Please join us for our annual meeting and tour of the Crispus Attucks Museum. We'll conduct a brief Marion County Historical Society business meeting followed by a guided tour of the museum. The museum is located on the campus of Crispus Attucks Medical Magnet High School and houses memorabilia from the first all African-American high school in Indiana. The museum has four galleries and over 70 exhibits. Exhibits range from school history and student achievement to local, national and international history.


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Key things you need to know aboutDr. Brown:
Dr. Brown's Experience
Research training, expertise and qualifications
Dr. Brown's Specialties
- Geriatric Medicine
- View all 2 specialties and 2 board certifications
Procedures Dr. Brown Performs
- Joint Drainage
- Myofascial Trigger Point Injection
- See all 4 procedures
Conditions Dr. Brown Treats
- Achilles Tendinitis
- Acute Postoperative Pain
- See all 50 conditions
More About Dr. Brown's Background
Hospital Quality
The right hospital is as important as the right doctor
- Highline Medical Center
- 16251 Sylvester Road Southwest
- Burien, WA 98166
9 Facts About Hospital Quality
Patients' risk of dying during a hospital stay for heart bypass surgery could be 85.2% lower, on average, at a hospital rated 5 stars compared to a hospital rated 1 star for that procedure. Choosing the right hospital is critical to your health. View Slideshow
Patient Satisfaction
Patients' feedback on their experience with Dr. Brown
Likelihood of recommending Dr. Brown to family and friends is 5 out of 5 5 1 6
See More Survey Results
8 Facts About Patient Satisfaction Surveys
Patient satisfaction surveys provide a standardized way of reporting about healthcare experiences. But there can be more than meets the eye when reviewing scores. Here's what you should know
Appointments & Offices
Check insurance plans, locations and make an appointment
Accepting new patients?
- Yes
- Marina Medical
- Marina Medical
- 22024 Marine View Dr S Ste 100
- Des Moines, WA 98198
7 Tips to Prepare for Your Appointment
The key to a successful appointment is communication. To get the most out of your visit, prepare ahead of time so you can lead the conversation with your doctor. These 7 tips will get you ready
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We have rich conversations with our clients every day, and increasingly these conversations are happening online. We encourage you to ask questions, share your views, and connect with like-minded professionals.
The International Annual Review demonstrates our achievements and reflects the insights and expertise professionals bring to client relationships.
KPMG's Global IFRS Institute provides information and resources to help Board and Audit Committee Members, Executives, Management, Stakeholders and Government Representatives gain insight on the evolving global financial reporting framework.
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The Chemical industry's landscape is changing fast - global companies are developing or launching new products and services – and appear optimistic - setting sights on geographic expansion.
Over the last two decades many industries have changed their value proposition by developing their customers' capacity to create value.
KPMG Global Manufacturing Outlook 2014 surveyed 460 executives worldwide, and offers practical and provocative insights to help organizations evaluate future strategies.
The global job search tool allows you to search available career opportunities within many of our 150 member firms worldwide.
KPMG's International Case Competition (KICC) is a chance for students to challenge yourself to solve a real business issue and an opportunity to meet new people across the globe.
Such doubts have largely been banished, as organizations around the world have removed obstacles or unnecessary steps to improve the quality of the patient experience, increase safety and efficiency, reduce costs and free up staff to concentrate on care rather than administration.
The goal now is to find a way to sustain these gains, with many hospitals struggling to maintain their early momentum after the first couple of years of effort. One of the greatest challenges in healthcare is to move beyond projects to make improvement part of the 'daily work' at the frontline.
Some hospitals have managed to break through this barrier to create an environment full of problem solvers, and in this paper we take a look at how they have made this significant leap forward in creating a culture of daily continuous improvement.
The insights gained provide valuable lessons for future success, laying out the path that hospitals can follow to become truly Lean.
© 2015
KPMG International Cooperative ("KPMG International"), a Swiss entity. Member firms of the KPMG network of independent firms are affiliated with KPMG International. KPMG International provides no client services. No member firm has any authority to obligate or bind KPMG International or any other member firm vis-à-vis third parties, nor does KPMG International have any such authority to obligate or bind any member firm. All rights reserved.


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- Article
- About the Authors
- Metrics
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- Related Content
About the Authors
- Aislyn D. W. Boran, Joseph Seco, Vinodh Jayaraman, Gomathi Jayaraman, Shan Zhao, Sushmitha Reddy, Yibang Chen, Ravi Iyengar
- Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, United States of America
Corresponding Author
Email: email@example.com
Competing Interests
The authors have read the journal's policy and have the following conflicts: U.S. Patent Application: AB, YC and RI "Cell-permeable peptides as receptor tyrosine kinase antagonists." U.S. Patent Application no. 61/107,650. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: AB YC RI. Performed the experiments: AB JS VJ GJ SR YC. Analyzed the data: AB JS VG SZ. Wrote the paper: AB RI.


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|The FIG Agency - Atlanta Video Production
Latest News & Happenings
According to new research from ReelSeo.com, the top brands all have a common YouTube trick: They post content on a consistent basis. In fact, the most successful brands publish 50 percent more videos per channel than the least successful ones. Think about that. The top brands publish 50 percent more video content than the least successful brands.
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Hope Is NOT A Marketing Strategy
It never ceases to amaze me how many businesses cross their fingers and "hope" their marketing efforts are successful. Effective marketing doesn't happen by chance, it happens by developing and deploying an effective and coordinated strategy. In this blog I'll cover three basic marketing rules and show you how we helped The Casting Exchange get over 8,000 social media interactions in ONE night.
Felton Interactive Group (FIG) is pleased to announce that is has joined the Bitcoin community and has started accepting bitcoin payments as of 12/23/2013.
(FIG) feels that bitcoin has matured to the point of being a viable currency and is excited to see what the future of Bitcoin holds in store. To learn more about bitcoin, please visit our client: BitPay.
Did you know? There is a distinction between capital-b and lowercase-b bitcoin. When capitalized, Bitcoin refers to the protocol and transaction network, whereas lowercase-b bitcoins are the currency itself.
Video is an essential tool for any company seeking to enhance its web presence, and allows your business to make a personal introduction, highlight your capabilities, and engage with your audience like never before.
o·rig·i·nal - adjetive: created directly and personally by a particular artist; not a copy or imitation.
Being original seems to be a dying art. People are either too lazy, too boring, or just plain too incompetent to be to original these days. If that's the case with your business...I hate to tell you you're 'doing it wrong', but YOU'RE DOING IT WRONG.
I'm the first to admit that I was beyond impressed when I saw Amazon's announcement of their new "Amazon Prime Air" flying drone delivery system. Now that I've had a chance to think about it, I'm beginning to think it's one of the greatest marketing ploys of all-time. Kudos to you, Jeff Bezos!
Your business needs to breakout and standout. It needs to be heard. If not, it's going to die. Today, we'll show you how video can help your business grab customer attention and spread your message.
So you're ready to film an interview. Great! Let's make sure you setup your lights properly in order to give you the best look & feel.
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Bvlgari Extreme Eau de Toilette Spray - Men's
Sorry, the item isout of stock
A stronger, longer-lasting version of Bvlgari, this Extreme eau de toilette spray boasts brilliant top notes. This defined men's scent sets the stage for a citrusy and fresh fragrance to last all day.
- Coriander, lavender, galbanum, tea, grapefruit, neroli, petit grain, bergamot, nutmeg, pepper, balsam fir, guaiac wood, Brazilian rosewood, cardamom, iris, sandalwood, musk, oakmoss and cedar.
- For men
Due to its contents, this product cannot be shipped via our Priority Service or sent to Alaska, Hawaii, and/or APO/FPO military addresses.
Due to its contents, this product cannot be shipped via our Priority Service or sent to Alaska, Hawaii, and/or APO/FPO military addresses.
Promotional offers available online at Kohls.com may vary from those offered in Kohl's stores.
Our hassle-free return policy means worry-free shopping.
- Return any item, anytime, for any reason.
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Who here is as addictef to BF1942 as me????
Can't get enough of this game!!!! MAps are huge and the gameplay is better thean Tribes or Tribes 2. Best multiplayer game I've ever played!!!! Anyone else as hopelessly addicted as me???:D :D
I like it, but it needs some work. Hit detection is seriously ****ed. I can unload a clip two feet away from a guy, and he doesn't get hit. As a sniper or engineer, I can hit NOTHING. I line up my crosshair, sometimes while they are standing still, shoot, and they do not get hit. My ping reads in the 40s, yet hit detection is seriously wrong. This is not just an issue with my computer either; EAs boards have many complaints of this.
It also gets chuggy when many things are on the screen. And not your "typical" choppy.... things start to get stuttery rather than choppy (as it would look in UT2003 when many things come on screen). It becomes very difficult to play in certain parts of maps (the omaha beach level gets quite skippy around the first hill). I remember this happening on the demo at times with my Geforce 3, and now it happens in the full game with the 9700. Great. :rolleyes:
The scope of the game is great, the graphics are great, the maps are amazingly large, and nothing out there has ever been done like this, but they need to fix the hit detection and performance issues before I can actually enjoy it.
I agree about the hit detection being FUBAR. The gameplay is what gets me though, it's just so addictive. There is like a ton of stuff to do!!!!!
I am trying to play the demo of this game, but it keeps going to the desktop asap. This is after I installed Nvrefreshtool.
Any suggestions. If i like the game ill buy it on Thursday :)
I think the drop to desktop is server issues.
Make sure you connect to the right server version. Not all of the servers have installed the 1.1 patch.
I know what ya mean about the stuttery stuff. Trying to take off from the AC when it's jumping about is a nightmare.
Top game tho.. With a few glitches ironed out, the full game will be awesome. Loads more vehicles, subs, more planes.. Top stuff indeed!
I got this game and think its a lot of fun. I hope that the next patch balances out the weapons a little bit. Either the regular guns need to be more powerful, or the rocket launcher needs to be weaker. Everyone runs around with a rocket launcher, taking on infantry in close combat. It shouldn't work that way.
My favorite part about this game has got to be the vehicles. The way they incorporated all the planes and boats and everything is just awesome. Between this and the UT2k3 demo, my weekend has been filled.
What a great weekend it has been. UT2003 Demo and Battlefiend 1942. I wish I could start the weekend all over again.
I think BF1942 is one of the best games to come out in a long time. The thing that hampers it right now are the bugs (net code/hit detection) and the need to tweak weapon damage. I think the game may end up being a masterpiece once some more patches come out.
The "back to desktop" issue is a refresh rate issue... BF doesn't accept if you set your own refresh rate... It has to be 60Hz in order to run the game...
But, a patch is out, grab it and install it... then edit the "VideoDefault.con" in the Setting folder which is in your game folder as well...
Change this value
renderer.allowAllRefreshRates 0
renderer.allowAllRefreshRates 1
that's it... now you can run the game in highest refresh rate available...
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over 1 year ago
Bonjour! I'm 14 years old and my name is Destiny, from USA. My life is Music, Photography, and Friends. Photography makes me feel more apart of a bigger place. You're Beautiful(: Zayn. Harry. Liam. Niall. Louis!
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Ocado British Mini Chicken Breast Fillets 425g
4 days guaranteed (avg. 4.5)*
Price per kg: £9.41
Product Description
Versatile and convenient mini chicken breast fillets are a perfect starting point for any meal. Stir fry them with noodles, roast and stuff into fajitas or roast them and toss into a Caesar salad.
Looking for inspiration? Our recipe for Chicken Stir-fried with Spring Onion, Basil, and Lemongrass takes less than 30 minutes for fresh Oriental flavours. For more recipe ideas click the tab at the top of the page.
Chef's tip: "for perfectly tender, flavourful chicken; marinate for as long as possible. 1-2 hours is great but overnight will really infuse the flavours"
Ocado chicken is succulent, juicy and rich in flavour. This is a result of the enriched diet that the birds are fed, as well as their living conditions. Our chicken is carefully selected by its British farmers who rear the chickens in rural locations in the British Isles.
Ocado provides chicken at affordable prices - without sacrificing any of the quality or high standards of animal welfare our customers expect.
Product Information
Meat & Poultry/
Breasts & Fillets
Feel Good Prices/
Meat, Fish & Poultry/
- Brands: Ocado
- Options: The Ocado range
Keep refrigerated below 5ºC.
Once open keep refrigerated and consume within 1 day.
Do not exceed the Use By date.
Freeze on or before the Use By date, use within 1 month. Defrost thoroughly before cooking. Once defrosted do not re-freeze. Consume within 1 day.
Cooking Instructions:
Remove all packaging. Wash hands, all surfaces and utensils after touching raw poultry. Keep raw poultry separate from cooked foods.
Electric 200ºC.
Gas Mark 6.
Place on a baking tray on the middle shelf of a preheated oven for 15 mins.
Pan Fry:
Heat 1 tbsp oil in a frying pan. Cook over a medium heat for 6-8 mins until thoroughly cooked, turning occasionally.
Appliances vary, these are guidelines only. Ensure the product is piping hot and the juices run clear before serving.
Chicken Stir-fried with Spring Onion, Basil, and Lemongrass
Country of Origin
Produced and packed for:
Ocado Retail Ltd.,
Package Type
Plastic Tray & Film
Other Information
Packaged in a protective atmosphere.
Whilst every care has been taken, some small bones may remain.
Customer Reviews
16 February 2015
1 of 1 found this review helpful.
I strongly agree with the previous review about the tendons in these! Will avoid from now on!
05 February 2015
2 of 2 found this review helpful.
Troublesome Tendons
These can be quite variable in quality, but the last few pack have had an unacceptable amount of large tendons attached to each fillet. The tendons are quite tough and time-consuming to cut through, outweighing any benefits from having pre-prepared mini fillets.
01 February 2015
Simply dusted in season all & dried herbs. Pan fried in a little rapeseed oil. Half went in sandwiches and the rest went in my homemade soup. A scrummy healthy lunch!
23 January 2015
Tender and succulent
These chicken breast fillets are some of the best I've ever tried. The portion sizes are just right, and they are love and tender when cooked. There was hardly any fat bits to trim and I didn't find any bones in mine!
12 November 2014
What bones
It's chicken Breast there are NO BONES been buying this product for over 6months never found a bone never been off always great with which ever dish I make be it casserole , stir frys , bbq chicken etc... Ignore boring bad opions there WRONG !!!!
Pad Thai
Easy-peasy inspiration for after-work meals and simple entertaining.
30 mins
Chicken Tikka Masala with Mint Yoghurt & Rice
This recipe is brought to you by Uncle Ben's.
25 mins
Mediterranean Chicken
A delicious tomato & herb flavoured chicken dish, inspired by Mediterranean cuisine, which creates a flavoursome meal.
50 mins
Chicken Tikka Skewers with Italian Salad and Minted New Potatoes
Tasty and versatile family favourite recipe, which can be cooked either indoors or outdoors on the BBQ, depending on the great British summer weather.
50 mins
Homemade chicken nachos
A super-quick Mexican snack to enjoy with a Margarita or three
13 mins
View all recipes containing Ocado British Mini Chicken Breast Fillets
- Life guarantee
- * Minimum life based on 'use-by' date of product. Average life based on last week's deliveries. Life guarantee shown based on delivery tomorrow and includes day of delivery. Please book a slot to view Life guarantee for your chosen delivery day. See Terms and Conditions for further details.
- Disclaimer
- These summary details have been prepared for information purposes only, and are designed to enhance your shopping experience on the Ocado website. While we have taken care in preparing this summary and believe it is accurate, it is not a substitute for your reading the product packaging and label prior to use. You should note that products and their ingredients are subject to change. If you do require precise ingredient information you should consult the manufacturer, whose contact details will appear on the packaging or label.
- Ocado is therefore unable to accept liability for any incorrect information. Where this description contains a link to another party's website for further information on the product, please note that Ocado has no control over and no liability for the contents of that website.
- You should also note that the picture images show only our serving suggestions of how to prepare your food - all table accessories and additional items and/or ingredients pictured with the product you are purchasing are not included.
- This data is supplied for personal use only. It may not be reproduced in any way whatsoever without Ocado Limited's prior consent, nor without due acknowledgement.


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Innova Vagabond Two Person Inflatable Kayak
The Innova Vagabond Two Person Inflatable Kayak is ideal for those who love sharing kayaking expeditions with a friend. It's made from rugged 1,200-denier Nitrylon that is highly puncture resistant, lightweight and easy to clean. This kayak features a wide design and a low profile, for easy handling in windy conditions. There are thigh straps to keep you securely in place, while you paddle away. An optional spraydeck is available to help cover your kayak when it s not in use and an included repair kit to mend any tear. This kayak is lightweight (38 lbs.) and stows away neatly into its own drybag/backpack, so you can carry it along on all your vacations and more. The Innova Vagabond Two Person Inflatable Kayak is a great choice for when you want to spend the afternoon out on the lake with a friend.