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Can a 17-year-old girl sign an apartment lease in the state of Washington without emancipation?
Most of your novels are romance related, though you've dabbled in the mystery department as well. When and why were you first interested in mystery novels?View Full Interview
How old do you have to be to be emancipated from your parents in Washington State?
Answer You have to be at least 16 in order the petition for emancipation in Washington state and you have to meet all the requirements in order for it to be gran…ted. Emancipation is rarely granted in any state. (MORE)
How can a 17 year old Emancipated Girl get a credit Card?
I am a 17yr old girl that has been emancipated and have run in to this question myself. I have found that most banks cannot issue a credit card to a minor, emancipated o…r not, unless they offer special types of accounts. Bank of America, whom I bank with, offers a student credit card that you can apply for if you are registered or currently attending a college or university. After graduating at 16 I applied for this type of account and was informed that unless I have a parent or guardian co-sign I could only be issued a debit card. After my emancipation and registering for a local community college I could be eligible for the credit card however. I now have a student credit card with Bank of America, it was very easy to apply for after I brought in my certified copy of my emancipation and proof that I had registered for the college. What I can recommend is ask around at different banks and see what they have to offer for emancipated minors, most banks will turn you away until you are 18 but if you are attending college or plan to do so soon Bank of America can help. (MORE)
How can a teenager move out in Washington state without being emancipated?
Answer You can�t. Not unless you have parental consent (and you're moving to a safe and appropriate environment) and even then your parents would still be res…ponsible for you. (MORE)
In Rentals
Different Types of Lease Options for Condos and Apartments
There are different types of lease options available for condos and apartments. You have the life lease, which is available to seniors. There there is the co-operative (co-op)… lease that requires you to apply to a board with very strict requirements for acceptance. Other options are rent-controlled and rent-stabilized leases. The non-stabilized prime lease applies to open market rentals, and sublets pertain to those people who are leasing from a primary leaseholder. With all of these lease options out there, it can be a bit confusing when you are looking for the option that will work best for you.The life lease is one of three options available to seniors. By choosing to move into condos that offer the life lease option, you no longer have the hassle of upkeep and maintenance associated with a larger family home. You are often able to purchase ownership in condos offering life leases at prices lower than the current market value. These condos tend to be part of retirement communities, so you can participate in the activities and clubs, while taking advantage of home and grounds maintenance by paying set monthly fees. There are some negatives to the life lease, however. Some life lease communities have age restrictions, so you need to investigate the community before signing the lease agreement. The big thing to understand is that with the life lease, you don't actually own the condo; you own the right to live in it. If you have a problem with living in a community sponsored by a specific cultural group, a church, or a not-for-profit organization, then a life lease may not be the best option for you. Most of these life lease options are managed by such organizations.The co-op lease gives you ownership of stock in the building where your unit is located, as well as the right to lease your unit. In most cases, utilities such as electricity, water, and sewage are included as part of the co-op fee. Usually the fees can be deducted on your taxes, since they include your share of the building's mortgage interest and taxes. Most co-op buildings have stringent security measures in place, so daily access to the building is very exclusive. One of the disadvantages is that the terms of this lease tend to be very strict, since anyone trying to make a purchase must be vetted by the co-op board members. Because any buyers must be vetted by the co-op board before the purchase can be approved, the selling process for your co-op condo can be very trying and time consuming. Another problem with co-ops is that there may not be that many of them available in your area. Also, financing for a co-op can sometimes be harder to get than that for a free-standing home, because the number of lenders that represent co-ops is limited. Many times you are unable to get pre-approved for a mortgage because the co-op you are looking at will only accept specific lenders.The rent-controlled lease is mainly used in high-population areas, such as San Francisco and the District of Columbia. One of the advantages of the rent-controlled lease is lower rents. The rent-controlled lease protects you from being evicted for minor infractions. You can only be evicted for what is considered a breach of contract, infractions such as violations of the lease agreement, illegal actions within the apartment or condo, or failure to pay the rent. Rent control restricts the landlord to raising the rent only once per year, and they can only raise it by a specific percentage established by either the state or city. One disadvantage of the rent-controlled lease is that people who live in such units may not want to move into better units. Another disadvantage is that in some cases, the landlord of a building with rent-controlled leases often feels that they don't have to maintain the building as well as they should because they can't charge tenants for the extra costs. This can have a negative impact on the property's market value, not to mention how the disrepair, appearance, and safety of the building affect the tenants. Also, the age of your building determines if it is eligible for rent-controlled leases; newer buildings are not eligible.The rent-stabilized lease is similar to the rent-controlled lease, except it is a more relaxed version. This lease is maintained by the city, usually by a rent stabilization board, or something similar. This board discusses terms with tenant groups and sets standard rent increases (in percentages), usually for all annual and biannual leases that come up for renewal within that calendar year. Termination of the lease cannot occur unless you don't pay your rent, damage the property, or violate the lease in some other way. This lease allows you to sublet your apartment or condo without violating the terms, provided you have met specific requirements. Just as it is with rent-controlled leases, a disadvantage of the rent-stabilized lease is that consumers are less willing to move, since this means giving up rent-regulated housing. The property values on these buildings tend to fall because of the landlord's lack of interest in maintaining the property. This leads to decreased revenues from property taxes for cities. Some rent-stabilized buildings require new tenants to pay costly finder's fees because available units are so hard to find.All of these different lease options can be confusing if you don't take the time to learn about them. The trick is to educate yourself before you start looking for that condo or apartment. Once you have found the perfect place, you might want to have a real estate lawyer look your lease over before signing it. The worst thing you can do is find out at the last minute that you missed something that could cost you money and possibly time in court.There are different types of lease options available for condos and apartments. You have the life lease, which is available to seniors. There there is the co-operative (co-op) lease that requires you to apply to a board with very strict requirements for acceptance. Other options are rent-controlled and rent-stabilized leases. The non-stabilized prime lease applies to open market rentals, and sublets pertain to those people who are leasing from a primary leaseholder. (MORE)
Emancipation Day: Washington, D.C. and its Historical Significance
Emancipation Day took place in Washington, D.C. on April 16, 1862. This important day served as the initial event that lead to the success of the hard fought battle for equali…ty when the 13th amendment was signed and enforced in 1865. This day continues to be a historically significant day that is celebrated every year in the Nation's capital. The day is a National holiday for the district and is filled with activities and celebratory features the remember the importance of this event.Washington, D.C. was right in the middle of the slave practices and related events that were happening during this time. It's presence in these happenings and the increasing number of blacks that were migrating to the capital seeking freedom put pressure on the President to do something about it. Several important historical events that took place in this area were the Nat Turner Rebellion of 1831, the Pearl Affair of 1848, and the presence of the Underground Railroad.The Nat Turner Rebellion of 1831 occurred Southhampton, Virginia and was lead by Turner after he murdered the family that owned him. His charge picked up momentum as other slaves began to join him as they rebelled against their owners. This event led to the panic and unease in the District as slave owners began to fear the implications of their slaves turning on them and rebelling.On April 15, 1848 75 slaves hailing from Georgetown, Washington, and Alexandria attempted to escape by jumping aboard the Pearl, a cargo schooner that was placed to wait for them along the Potomac River. Two white men, Daniel Drayton and Edward Sayres orchestrated the escape for the slaves. Bad weather delayed the departure and the escape attempt was unsuccessful. Drayton and Sayres were jailed, and received harsh treatment from area slave owners and other locals who wanted them hanged for their role in the event. The escapees were also jailed and sold to slave owners in the south. This event was the largest escape attempt in the Nation and drew attention to the increasing instability of the slave trade in the Capital and the need for change.The Underground Railroad, was established by Harriet Tubman as a collection of hiding places, hidden roads, and people that would help slaves escape to freedom in the North. This pathway ran close to Washington, D.C. and increased attention to the current state of slavery and established the need for change. All of these events were important factors to Emancipation Day, the Emancipation Proclamation, and the establishment of the 13th Amendment.Abraham Lincoln was President during this time and came to the realization that slavery needed to be abolished. As more and more freed and escaped slaves flocked to the Capital seeking refuge the sense of urgency was established. On April 16, 1862, President Lincoln rewarded local slave owners for releasing their slaves. He went on to declare his plan to spread this abolition, nationwide. Emancipation day lead the charge for freedom and Lincoln's decision was the spark that led to the following events that changed the course of history.Emancipation Day ended slavery in the Capital nearly 9 months before the Emancipation Proclamation was issued. The Preliminary Emancipation Proclamation was declared shortly after Emancipation Day and addressed Lincoln's plan to continue abolition on January 1, 1863. Efforts were continued as Union Troops sought to overtake confederate states and free their slaves. Eventually slavery was completely outlawed nationwide in December of 1865 when the 13th Amendment was passed.The year after the original Emancipation Day, former slaves in the community, organized a massive parade to celebrate the anniversary of the their freedom. To this day, April 16 remains a holiday in Washington, D.C. as businesses and school are closed to celebrate an important day that holds such historical significance. The city is booming with parades, fireworks, activities, and entertainment to celebrate the Capital's role in the hard fought battle for freedom.Washington, D.C. was right in the middle of the events that took place regarding slavery in the mid 1800s. It's proximity to several major events forced the Capital and its leaders to take action against slavery and establish change to settle the unrest that was occurring this area, as well as, in the rest of the country. The Emancipation Day served as an important precedent to the major acts that followed. This day was a catalyst for freedom and equality and will continue to be celebrated every year.While these events led to the eventual freedom of African slaves, they still faced many battles ahead of them. Once such legal battle was for citizenship for the freed men and women. While the slaves were released from the holds of their owners they were not automatically granted citizenship or equal rights. (MORE)
In Rentals
Types of Rental Leases to Consider
Once you have found the perfect home or apartment to rent, it is time to sign a rental agreement with the owner of the property. This is basically the deal that you are creati…ng that will allow you to live in their property within the specified parameters. The law dictates that a landlord must provide their tenants with a written lease. There are several different types of leases that you may encounter, understanding their requirements are essential if you plan to rent a house or apartment.This is the most common type of lease for homes and apartments. There is a set rate that is agreed upon by both parties. This rate will not change for the period of the lease. Upon renewal, the rate can be negotiated again, which may or may not change the terms. This flat or fixed lease is created for a definite time period.With a gross lease, the tenant will pay a flat rate and the landlord will cover all of the operation costs. The utilities are negotiated to determine who will pay these expenses. A gross lease will also typically carry an escalation clause. This will allow the landlord to raise the rent price each year. This is done only to cover the increased cost of living and other expenses.A step lease provides provisions for the rent to be increased regularly for the life of the agreement. This is typically raised on an annual basis, yet may be customized to different time periods. The increase is agreed upon in order to cover any increases in the landlord's expenses. This increase is an estimate, and not based on the actual expense increases that may or may not occur. This type of lease is often seen in areas where the cost of living is high.A net lease is designed to increase the rent rate dependent upon the actual costs, instead of estimated ones. They are designed to allow the landlord to increase the rent when their expenses are increased. These leases often designate that the tenant will pay the entire rent, as well as the real estate taxes. If this lease is used in a multi-dwelling apartment building, then the rates will be proportionate to their portion of the building. This will ensure that they only pay the rent and taxes that are for their portion of the building.The Net-Net lease designates that the tenant of the building will pay the rent, as well as the insurance premiums and taxes. These are figured based on the space that the tenant is occupying in instances of apartment buildings. A Net-Net-Net lease is when the tenant will pay all associated costs. This includes the operating costs that the landlord incus, as well as insurance, repairs, maintenance, and taxes on the property. These costs can get expensive and this should be considered prior to renting under these conditions.No matter the type of lease that you decide to sign, you should understand all of your responsibilities. This will ensure that you will be able to budget for the increasing rates that may occur. A fixed or flat rate lease is the most common; however, with rising costs of living, many landlords are opting for other versions to reduce the expenses that they incur. There is no right or wrong lease. However, you should consider if it is right or wrong for your specific situation.It is important to read all portions of a lease prior to signing. If you do not understand something, then you should ask questions. This may prevent you signing a lease that you do not want to be held to. (MORE)
In Counseling
Emancipation Definition, Process and the Importance of Counseling
To some degree, conflict between parents and children is a perfectly normal part of family life. In some instances, however, the conflicts go beyond everyday sparring and reac…h into emotional or physical abuse and neglect. For the children in these circumstances, emancipation can be a viable option for improving their well-being. Counseling can be extremely valuable for children and parents who are thinking about or going through the emancipation process. The following will help better understand the emancipation definition, the process, and the importance of counseling when considering emancipation for a family member.Emancipation is a legal way for a minor child to win the status of adult. With that status, you can earn the right to engage in most business or personal activities - for example, buying a car or moving - without the consent of your parents. This includes participating in legal contracts. Normally, parents are legally responsible for the welfare and behavior of their children until they reach the age of consent, usually 18, but when you are emancipated, this no longer applies, and you can be held legally accountable for your activities.The exact procedure for becoming emancipated varies by jurisdiction. Generally, however, in the United States, you must be at least 14 years old and file a formal petition with your local family court. You will need to prove to the court that you are able to take care of yourself financially, which includes managing your money as well as earning it. You must demonstrate that you have good reasons for not wanting to be under your parents' control anymore, as well. However, you also can become emancipated through military service or marriage.Living with a relative or forging an arrangement with your parents to live outside their home can be a good alternative to legal emancipation in some cases. Some children are able to turn to agencies that provide resources they might not be getting at home, making emancipation unnecessary. They do not always know about these organizations or how to contact them, however. Courts often alert minors to what is available when children go to file for emancipation as a way to try to keep families together.Counseling is critical to minors who want to be emancipated for several reasons. First, it can help them better understand their home environment and family dynamics. In some instances, these insights play a key role in enabling the minor and other family members to reduce conflict. Often, although minors can be very mature for their age, their lack of life experience sometimes puts them at a disadvantage in terms of knowing what it really will be like when they are on their own. Counselors can provide minors with facts that can help them come to a final decision about whether the emancipation process actually would be good. They also can help minors cope with the often-overwhelming emotions that come with having to be emancipated and finally receiving that freedom. Another way counseling can help is through identifying specific goals, such as being able to find a job with good income in a set period of time. Parents sometimes want counseling to deal with the feelings and circumstances that led to the emancipation, or to try to repair their relationship with their emancipated child.Emancipation refers to the legal process by which a child earns the status and the majority of the rights of adulthood. You can be emancipated through the court, or by military service or marriage. Professional counselors and legal workers often suggest alternatives to emancipation, such as living with a relative, when they feel those alternatives are in the best interests of the child and are logistically sensible. Many people find counseling valuable when they are considering, going through, or have completed the emancipation process. This series of questions has provided you better understanding of the emancipation definition, the process, and the importance of counseling when considering emancipation for a family member.One of the things courts consider when looking at an emancipation request is the best interest of the child. The problem here is determining what constitutes best interest. It is this element that makes winning emancipation tricky, so the clearer case you make for how being on your own would be better than life with your parents, the more likely the court will rule in your favor. (MORE)
In Lifestyle
10 Child Stars Who Were Emancipated From Their Parents
Cast at age six as Cindy Lou Who in 2000's "How the Grinch Stole Christmas," Taylor Momsen gained prominence as Brooklyn-born Jenny Humphrey on the show "Gossip Girl." She has… also fronted the rock band The Pretty Reckless since 2007.Because she graduated from high school at age 16, New York State law automatically considered her to be an adult and allowed her to fully emancipate from her parents.The daughter of late Nirvana frontman Kurt Cobain and singer Courtney Love, Frances Bean Cobain was only two when her father committed suicide in 1994. Courtney Love admitted taking heroin while pregnant with Frances. In 2009, Courtney lost custody of 17-year-old Frances to her daughter's paternal aunt and grandmother, and her daughter became emancipated.After starring in "Home Alone" at age 10, Macaulay Culkin became increasingly estranged from his never-married parents following their separation. A bitter legal battle over his fortune and other six siblings ensued, culminating in Macaulay's legal emancipation at age 14. His mother gained custody of the other children. Culkin no longer communicates with his father, who was his former manager.After teenage actress Jena Malone and her mother Deborah made loans to various family members, they found they owed more in taxes than they anticipated. The two experienced plenty of friction, and Deborah agreed to sign her daughter's petition for emancipation, giving her access to her trust accounts to settle the tax bills. Malone earned her GED and appeared in films such as "The Hunger Games: Catching Fire," "For Love of the Game," and "Stepmom."While shooting 1993's "The Crush," 15-year-old Alicia Silverstone sought and received legal emancipation so she could work enough hours to complete the film. Her father, real estate professional Monty Silverstone, and her mother, former flight attendant Didi Silverstone, supported her decision, and there was no conflict among the family members. In 1995, she burst into prominence as the star of "Clueless" and appeared in "Beauty Shop" and "Angels in Stardust." She is now a best-selling cookbook and lifestyle author.In 2012, 14-year-old "Modern Family" star Ariel Winter sought legal emancipation from her mother, citing emotional abuse. Chrystal Workman lost custody of her daughter that year, and the court finalized Ariel's emancipation petition in May 2014. Ariel's older sister Shanelle became her permanent legal guardian.At 15, teen idol Aaron Carter fired his mother and manager Jane Carter, alleging she helped herself to more than $100,000 of his earnings. He filed for, and received, emancipation from her in 2003. Carter's hits include "I Want Candy," and he appeared on "Dancing With the Stars" in 2009.Before Kim Richards became part of the "Real Housewives of Beverly Hills" cast, she was a sought-after child actress. At six, she appeared in "Nanny and the Professor," and at 11, she appeared as Tia in Disney's "Escape to Witch Mountain" and "Return to Witch Mountain." As a teen, she became emancipated from her parents Ken and Kathy Dugan in an effort to gain control over her earnings.At age 15, "Stand By Me" star Corey Feldman became emancipated from his parents after discovering he had only $40,000 left in savings. He alleged that his parents mishandled his financial affairs. He fell into drug abuse and embarked on a short-lived marriage at age 17.Now an actor, producer, and director, Drew Barrymore starred at age nine in the 1984 film "Irreconcilable Differences," which centered on her character Casey's emancipation from her quarreling parents.After struggling with substance abuse and two rehab stints, she won emancipation from her parents at age 15 to extricate herself from an erratic upbringing. She told "60 Minutes" that she learned about emancipation while making "Irreconcilable Differences." (MORE)
In Finance
Leasing Commercial Property
Business owners need to ensure that they have some kind of property in order to successfully operate. At first, some owners might be able to get away with running things from …a home office. Businesses that want to cater towards even small customer bases will need commercial property. Leasing commercial property can be quite different from renting residential property. Read below for a summary of this type of lease and related financial information.A big difference between commercial leases and residential leases is the level of protection. Residential leases have much more protection than commercial leases. That means it is even more important for business owners to carefully go over their leases before they sign anything. Residential leases are also more generalized, while commercial leases are more customized to meet the needs of each individual business owner. This can work in the favor of the business owner, since the owner has more room to negotiate and can be a little more flexible when setting terms, but once those terms are set they will be strictly enforced.The first thing that most business owners will notice is the length of a lease. Shorter leases are usually sources of concern, since often short leases are vague on the specific terms. This will not usually end up favoring the business owner. Longer leases are obviously more difficult to read, but will be more precise. Business owners need to make sure that all of their payment dates are clearly laid out, and check for renewal options and make sure that they won't suddenly lose their property.While the general length of the lease is the first thing that most owners notice, the rent section tends to get the most attention. Rent dictates how much gets paid, and most importantly when payments need to be made. In addition to that, the rent section usually details how and where the payments need to be made. This section typically includes what happens if the rent isn't paid. Usually this will be additional late fees, but some leases are stricter, and one missed payment might result in loss of property.It is rare for business owners to find commercial property that won't need to be modified in some way. The only potential exception is buying or merging with another business, but even then there might be modifications that need to be made. The property owner will dictate what modifications are and aren't allowed while the business owner is just leasing. Another important area business owners need to consider is advertising. This includes in-store advertisements such as setting up special display cases and the like, but also larger things such as business signs, so customers can find the building in the first place.Renewal options are very important for business owners. Having to move locations can be quite expensive and time consuming. Business owners should avoid leases that allow for any sudden termination. Depending on the property, business owners also need to be aware of any other leasing space on the property. If they don't rent out all the space, then there is always the possibility that another business will rent out the space, unless otherwise detailed in a contract.Anyone looking to lease commercial property needs to pay careful attention to their contract. Lessees should avoid any short, vague contracts and focus on detailed leases. Rent is something that needs to be clearly outlined, as do options for renewal and termination. The lease should also have details about any modifications that can be made to the building, including any changes for advertisements.Business owners need to make sure they follow the Americans with Disabilities Act. This act states that any business that offers services to the public needs to provide access for anyone with disabilities. This also applies for businesses that have 15 or more employees, even if they don't cater to the public. (MORE)
Can a 17-year-old sign a lease for an apartment in Michigan without emancipation papers but with parental permission and a boyfriend being the main leaser on the lease?
Answer The legal age of majority for the state is 18, anyone under that age cannot enter into a legal contract of any sort, unless an exception has been gra…nted by the court of jurisdiction. (MORE)
Can a 17-year-old in a state without emancipation move out because they think their parents are unfit to take care of them?
Answer Probably not. If you have a department of children and family services in your state, call them if you're in a dire situation. If you're just antsy to ge…t out of your parents' home because you're 17 and can't wait to be 18, stick it out. It's a lot tougher to live on your own than you think. Answer Not legally. But, here is something the person might wish to consider; even though a state does not have established grounds and procedures for emancipation action it does not mean said person cannot file such a petition. The interested party might wish to contact the circuit court clerk in the city or county where they reside for specific information. (MORE)
Can a 16 year old lease an apartment in new york state?
No, because in New York State, the 16 yr old's signature is of no legal effect. The kid lacks the legal capacity to create the contractual relationship (with limited exc…eptions that are not applicable here). (MORE)


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Tagged: kitty
"When we get older, we start getting heavy," this fat cat with the banjo sings. "One day we find we weigh as much as your average Chevy." This chubby kitty says that no matter how much you diet and exercise, the fat comes back the very next day.
"And they call it kitty love, I just want you to know. How good a hug really feels and why I love you so." So sings the cutest baby to ever wear a pink leopard cat suit. His cuteness is rivaled only by the slideshow of kittens. Every cat lover will go "ahhhh" to this clip.
Watch as this cat goes bonkers over a laser pointer.
An adorable video of a kitten falling asleep while standing up.
Hey Ma! Your kid is trying on your clothes, and drawing on the wall like Michelangelo. He even put kitty in the toilet and turned him blue! Sung to Outkast's "Hey Ya" this song shows how one baby can cause a lot of trouble once he starts walking.
Let this little blue-eyed kitty cat tell your loved one, "I'm so sad without you, I really hope I'll see you soon!" If you're missing someone, use this message to let them know they make your days bright and put joy in your heart.
"Hug me, hug me, please won't you hug me?" These adorable little kitties just wanna be hugged, but do it gently, or they'll cry. Sung to the tune of "Lovefool" by the Cardigans, these precious kittens only need "just one hug from you." Pretty pwease?
A kitty sings a song about why it's so great to be a cat!
Can you dig it? The new Shaft is in town... Shaft Cat!
Kittens, free to a good home! Living in a box, these Kentucky kittens are awfully lonely and they want to come home with you. "Aren't we just the cutest things that you ever saw? We'll rub up against your leg, and we'll never claw!" These cute cats will love you till the end. Don't let these kitten's die in a shelter, adopt one today.

subset: commoncrawl


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The Global FlyFisher - The Largest and Best Place to go for Online Fly Fishing and Fly Tying
GFF Videos
Tying an Intruder
Submitter:Martin Joergensen
|More great articles on The Global FlyFisher
|A couple of random articles
TV tying stationA tying station is a small, mobile board where you can set up your vise and your tools, making it quick and easy to move your favorite tying spot around: from the dinner table to the TV to the office to... the bed? This article gives you some ideas on how to make one.
February 7th 2006


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Privacy and Cookies
Alenia Aeronautica chief executive Giovanni Bertoleone has revealed that his company is still in talks with Boeing over joint production of the C-27J Spartan airlifter - little over a month after the company told Flight International that the talks had ended without resolution.
Bertoleone says that a joint venture with Boeing is "one option" being considered, adding: "We need to decide quickly Boeing is considering a solution to participate." He notes that his statement confirms remarks made earlier at the air show by Boeing chief executive Jim McNerney.
On 9 June, Boeing's president of precision engagement and mobility systems Chris Chadwick told reporters that the company was "trying to close the business case" with Alenia regarding a final-assembly facility in Jacksonville, Florida, but Alenia promptly denied this, saying: "After negotiating with no real success, we jointly made the decision that Alenia could not afford to delay our investment any more in Jacksonville."
At that point it appeared that Boeing had exited the Joint Cargo Aircraft team, leaving the two remaining members - Alenia Aeronautica and L-3 Communications - to take full responsibility for deliveries of C-27 airlifters to the US Army and US Air Force, the first of which is scheduled for October.
The revelation that Boeing-Alenia talks are ongoing represents the latest twist in a saga of claim and counterclaim. At the Paris air show last year, Boeing disputed an L-3 executive's suggestion that Boeing's role in final assembly would not begin until after the 20th aircraft was delivered.
Alenia and Boeing were at the time negotiating to open the second final assembly line in 2010, when the team is scheduled to deliver the 10th through the 14th aircraft to the army.
Intended as a rugged military airlift platform, the C-27J has a maximum payload of around 11,000kg (24,230lb). It is configurable for troop, medical evacuation, airdrop, or cargo missions.
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Eminem, "The Eminem Show," Aftermath/Interscope. The rapper's album is too long at almost 80 minutes, but its highlights offer Eminem's most gripping and revealing statements yet.
Bounty Killer, "Ghetto Dictionary," VP Records
Cordelia's Dad, "What It Is," Kimchee
Nik Freitas, "Here's Laughing at You," Future Farmer
Hutch, "Turn it Around," Smile/Image
Japancakes, "Belmondo," Darla
David Johansen & the Harry Smiths, "Shaker," Chesky
Mother Superior, "Sin," MuscleTone
Jill Olson, "My Best Yesterday," 125


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NewsJune 27 2012
Change in PHS alumni plans
The Presho High School Reunion will be held on August 4 and 5, 2012, at a new location—the Catholic Church in Presho.
It was planned for the school auditorium, but the floors are being done and cannot be walked on during that time. The reunion begins at 6 PM on Saturday (doors open at 5 PM). The potluck lunch on Sunday will begin at noon at the church.
Local alumni are asked to please bring salad or dessert to each event. Sunday is not leftovers but a potluck luncheon.
Classes ending in '2' and '7' will be honored at the reunion. According to correspondent secretary Sandy Swinson Kessler, entertainment from the honored classes would be appreciated.
Election of officers will also be held. All officers have indicated that they have served several years in a row and would like to step down. A new president, vice president, secretary-treasurer and corresponding secretary will have to be found. The nominating committee is Wanda Lee Sweeney, Beverly Johnson and Bev Cleveland. If you know of someone interested, or if you are willing to serve, please let them know.
If you have questions, please contact Sandy Swinson-Kessler, c/o The Directory, 3106 West Broadway, Missoula MT 59808. 406-549-4551 or e-mail to direct©montana.com
- Scavenging through the county
- WCE Cooperative finishes up repairs after weekend storms
- High winds damage structures,
- North Central Farmers Elevator and South Dakota Wheat Growers Member-Owners Vote No on Unification
- Lyman School Board Election results
- Construction at new elevator site stays on schedule
- What's new at the museum
- Local Lions Club projects recognized
- Lyman reunion moves to Clubhouse
- Remebering those who gave all
- Presho HS reunion set


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Maple Roasted Chickpeas, detoxing and healthy snack to satisfy your sweet tooth#35258
Delicious Chocolate Tart with fresh fruit and chocolate crème patissière, amazing!#35245
Beaujolais Nouveau, vanilla, honey, spices and fruits - warming and comforting experience#35241
Savory Bread Pudding Muffin, fluffy, eggy, cheesy and hearty, the perfect breakfast on the go!#35239
Goan Chicken Coconut Curry, easy and skinnier revamped version of this family classic, made in a slow-cooker#35238
Persimmon and Yogurt Marsala Dessert and Villa Farnese in Caprarola, Italy#35236
Stovetop Popped Corn tossed with toasted coconut flakes and honey/butter/vanilla drizzle#35234
White Mulled Wine with oranges, vanilla and cinnamon - ultimate festive drink that will warm you up in seconds!#35232
Thanksgiving leftovers? combine your pumpkin pie with three incredibly decadent ingredients, and have a treat that might even top the T-Day feast#35231
Butternut Squash and Garbanzo Curry Vegetarian curry recipe. A light vegetarian meal to get the weekend off to a healthy start.#35228
Cayenne Maple Walnuts, quick snack to make and enjoy on its own, or add to cheese plate with brie and gruyere#35223
Spaghetti al Nero di Seppia (Squid Ink Pasta), dish inspired by trip to Venice#35222
Hot Chocolate Mix with Cinnamon and hint of Cayenne is pretty much the best thing ever!#35219
The Loaded Nacho Grilled Cheese - perfect for game day, watch us prepare it on live TV!#35218


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Paul Turner
Louisiana Tech totaled a league-best 15 selections on the preseason list
A total of 124 Tech athletes earned the academic honor
Short scrimmage planned for Wednesday's practice
Bulldogs look for depth and leadership
University honors 22-member senior class
Photos from LA Tech vs. Rice on Nov. 29, 2014
Photos from the 2014 Louisiana Tech vs. Western Kentucky game
Louisiana Tech at Southern Miss in Rivalry in Dixie game
Louisiana Tech Football at North Texas
LA Tech at Louisiana-Lafayette
2013: Ruled ineligible to play in 2013 due to the NCAA transfer rule.
2012 (LSU): Played in nine games with no starts ... Saw action in a backup role at wide receiver and on special teams ... Did not record any statistics.
2011 (LSU): Redshirted as a true freshman in 2011.
High School: Dynamic athlete who played both sides of the ball ... Primarily ran the option from the quarterback position in high school and projects as either a safety or wide receiver at LSU ... Led West Monroe to a 5A State Championship in 2009 and state runner up in 2010 ... Voted Louisiana Sports Writers Association 5A Most Outstanding Offensive Player ... A member of the LSWA 5A All-State Football team in 2010 and an honorable mention in 2009 ... Ranked No. 11 in Louisiana by Tigerbait.com and as the No. 32 athlete in the nation by Rivals.com ... A consensus three-star prospect by every major recruiting site ... Passed for 1,245 yards and 14 touchdowns his senior year to go along with 974 yards rushing and 14 touchdowns ... Member of the New Orleans Times Picayune's Blue-Chip List ... Selected to the Baton Rouge Advocate's Second Dozen ... Maintained a 4.0 GPA entering his senior season ... Coached by Don Shows.
Personal: Paul O'Neal Turner ... Parents are Carl and Paula Turner ... Born May 10, 1993 in West Monroe, La.


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FN legal awards: Financial regulation team of the year shortlist
Here is the shortlist for the financial regulation team of the year category at the inaugural Financial News Awards for Excellence in Legal Services, Europe, which celebrate the achievements of the best law firms, teams and individual lawyers supporting the financial markets throughout the past year. The winners will be announced at a London gala event on April 24.
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Stop the torrents: ISPs to block piracy websites, send warnings
The Australian government is moving ahead with plans to crack down on online copyright infringement, with website blocking and warning notices coming in 2015.
The Australian government is moving ahead with plans to crack down on online copyright infringement, with website blocking and warning notices coming in 2015.
The Department of Finance has listed a request for tender on AusTender for suppliers interested in helping the government establish a whole-of-government cloud services panel.
In its response to the Australian government's online copyright infringement discussion paper, iiNet has called for the government to rethink what it means by online copyright infringements.
Bing's 'Image Widget' lands the software, services, and devices giant in hot water. The damages to Getty are "incalculable," the lawsuit says.
New documents reveal the existence of the US spy agency's ICReach, a search engine similar to Google which links to citizen communications data.
A new record has been set for the number of URLs that Google is asked to remove from search results over alleged copyright infringement.
Why would content owners want to make their products more easily available when the Australian government appears to be focusing entirely on deterring and punishing users for copyright infringement?
Emails to the Attorney-General's Department from the Australian Screen Association since the election show the group is keen on seeing the government act to stop online copyright infringement
Singapore's ICT regulator blames a vulnerability in Google's search bar for the breach that defaced two government sites including the prime minister's, after he pledged to "track down" hackers who target the country.
Ahead of what could be a crackdown on copyright infringement by a new Australian Coalition government, a study suggests that graduated response schemes to deter online copyright infringement don't work.
Unclear definitions, not patent trolls, are at the root of recent rises in software patent infringement suits, a new U.S. Government Accountability Office study finds.
One U.S. law enforcement agency is struggling to snoop on messages sent by Apple devices, claiming they "cannot be intercepted." But lack of transparency on Apple's part may mean the technology giant is facing an influx of search warrants — and yet we don't know about it.
U.S. court dismisses a 2011 lawsuit against the Chinese search giant alleging it worked with its government to censor the Web.
In a "frequently asked questions" page, the search giant explains what exactly happens when a government agency or law enforcement requests your personal or private data.
The company has initiated a campaign against German government proposals that would force search engines to pay a copyright fee every time they bring up a snippet of a news story in their results.
The U.S. government is preparing an antitrust case against Google over its search monopoly, reports say, and could issue a formal complaint in the coming weeks.
Government lifts ban on Google's e-mail service after blocking it last week, following plans to introduce domestic versions of search and e-mail services soon.
Country announces plans to move citizens to its local Internet system after connecting government agencies to the platform, and said it will block access to Google's search and e-mail services.
The government wants to give access to more telecommunications data to assist with law enforcement. It sounds like an infringement on civil liberties. Will it be able to push it through?
Google is changing its search-engine algorithms to push down the search rankings of websites that receive large numbers of copyright-infringement notices.
Enterprise Software
Perfectly legal ways you can still get Windows 7 cheap (or even free)
How much does an iPhone 6 really cost? (Hint: It's way more than $199)
Windows 10
How to survive an iPhone liquid submersion (hint: it's not rice)


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Surnames Hellebaut to Hellegeist Free Family Genealogy
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Company Details
- Miami Dolphins Partner With AARP Foundation To Benefit Older Adults WFOR - CBS - Miami, FL
- Former Wells College president Ryerson named AARP Foundation president The Arcade Herald - Local News
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August 01, 20131:30 pm - 2:30 pm
Meet farmers, merchants, builders, and teachers who built up America in times of tyranny and Revolution. Tickets are required, visit http://www.colonialwilliamsburg.com/plan/calendar/meet-nation-bldr/?eventId=11922&startTime=08-01-2013+13:30:00.0 to reserve them now.
Kimball Theatre
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I rather see the New York Jets Mark Sanchez run into the butt of his offensive lineman than see his actual butt anytime of day. The most notorious play of the 2012 NFL season, where Mark Sanchez ran into his own team, only to fumble the football, which was then returned for a touchdown. Why am I describing this to you? You know the play. But did you know that it was turned into a silent film, ala Charlie Chaplin? Gadzooks! Via FTW: That's some creativity. Silent, yet deadly.
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Two Great Tastes Pudding Parfaits
2 Dec 2009
|Vanilla pudding and pie filling
|4 3⁄4 Ounce (1 Package)
|3 1⁄2 Cup (56 tbs)
|Peanut butter chips
|1 Cup (16 tbs)
|Semisweet chocolate chips
|1 Cup (16 tbs)
In large, heavy saucepan combine pudding mix and 3 1/2 cups milk (rather than amount listed in package directions).
Cook over medium heat, stirring constantly, until mixture comes to full boil.
Remove from heat; divide hot mixture between 2 heat-proof medium bowls.
Immediately stir peanut butter chips into mixture in one bowl and chocolate chips into mixture in second bowl.
Stir both mixtures until melted and smooth.
Cool slightly, stirring occasionally.
Alternately spoon peanut butter and chocolate mixtures into parfait glasses, champagne glasses or dessert dishes.
Place plastic wrap directly onto surface of each dessert; refrigerate several hours or overnight.
Top with whipped topping and garnish as desired.
Rate It
0 Comments
Two Great Tastes Pudding Parfaits Recipe


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Hang tight!
Recipe by TRICIAMARGARET
"This is an old family recipe that originates from Yorkshire England -- you can try substituting maple syrup or jam for the golden syrup."
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1/2 cup
1/2 cup
white sugar
eggs, beaten
1/4 teaspoon
vanilla extract
1 3/8 cups
self-rising flour
2 tablespoons
4 tablespoons
golden syrup
This is the best pudding recipe I have come across and is really delicious for those of us who enjoy the taste without worrying!!
I made this recipe for a potluck with a UK theme. Some people really enjoyed it
and others didn't liek it at ALL. I used a raspberry syrup and was pleased
with how it came out.
6 Ratings
Really yummy and easy to make.
the worst bit was waiting for it to cook in the oven! but was definately worth the wait.
light, fluffy and lovely syruppy topping- Thankyou!
Excellent pudding. My husband is British & loves this recipe accompanied by Birds custard. Thanks so much.
Yummi! I mace it twice and we ate it all on a seat. The second time I tried with maple syrup and turn up great. Thank you for such an easy and delicious recipe.
I wanted this as my Birthday Cake this past week. We added a few more tablespoons of syrup. If you don't eat it hot out of the oven - you miss out. This was delicious!!! A real Treat!
* Percent Daily Values are based on a 2,000 calorie diet.
Syrup Sponge Pudding
Serving Size: 1/4 of a recipe
Servings Per Recipe: 4
Amount Per Serving
Calories: 546
Calories from Fat: 229
French toast is such a perfect breakfast, light lunch, or even supper on these warm days.
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See what it takes to make a complete "homestead meal" including tapioca pudding.
See how to make rich, delectable vanilla pudding from scratch. It's simple!


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Kazakh opposition leader jailed after oil town unrest
AKTAU, Kazakhstan, Oct 8 (Reuters) – An outspoken critic of
Kazakhstan's veteran president was jailed for seven-and-a-half
years on Monday for colluding with a fugitive billionaire in a
failed attempt to rally oil workers to bring down the
Vladimir Kozlov, leader of the unofficial Alga! party, was
found guilty of orchestrating dissent among striking oilmen in
the prelude to riots last December that left 15 people dead and
dented Kazakhstan's reputation for stability.
Kazakh key rate hits historic low as inflation dips
ALMATY, Aug 2 (Reuters) – Kazakhstan's central bank said on
Thursday it would cut its key refinancing rate to a new historic
low next week, its fourth cut in less than half a year, in
response to falling inflation in the oil-fuelled economy.
The bank said in a statement it would cut the rate to 5.5
percent from 6.0 percent, effective from Aug. 6. The bank last
lowered the rate, also by 50 basis points, on June 4.
Uzbekistan bans foreign military bases on its land
ALMATY (Reuters) – Uzbekistan is moving to ban foreign military bases on its territory, local media reported on Thursday, ending speculation it could allow the United States to reopen a base for operations in neighboring Afghanistan.
However, some analysts said the ban might not prevent military cooperation with the United States, which could still use Uzbek facilities for special-forces operations to fight the Afghan Taliban or other regional threats.
ArcelorMittal agrees pay deal with Kazakh workers
ALMATY, July 17 (Reuters) – ArcelorMittal ,
the world's largest steelmaker, said it will return to the table
in October after agreeing a temporary pay deal with its
Kazakhstan plant workers to avert a threatened strike.
ArcelorMittal Temirtau, the company's Kazakh unit, awarded a
10.4 percent pay increase to its steelworkers backdated to Jan.
1. A local trade union representative said the deal, which fell
short of workers' demands, was a temporary measure.
Russian Soyuz rocket blasts off for space station
ALMATY (Reuters) – A trio of Russian, Japanese and U.S. astronauts blasted off aboard a Soyuz spaceship on Sunday for a four-month mission on the International Space Station (ISS) that Moscow hopes will help restore confidence in its space programme.
Veteran Russian cosmonaut Yuri Malenchenko, NASA astronaut Sunita Williams and Japanese astronaut Akihiko Hoshide launched successfully aboard the Soyuz TMA-05M rocket from the Baikonur cosmodrome in Kazakhstan at 0240 GMT (2240 EDT on Saturday).
Kazakh steel union eyes strike at Arcelor unit
ALMATY, June 29 (Reuters) – Thousands of workers at
ArcelorMittal's steel mill in Kazakhstan staged
a three-hour strike on Friday and warned of wider action to back
demands for a 30-percent pay hike.
The labour union at ArcelorMittal Temirtau, which said 3,000
staff joined the first-ever stoppage at the plant, has rejected
a company offer of a 10-percent rise and has called for a halt
in job cuts.
Kazakh court jails 13 for oil town riots
AKTAU, Kazakhstan, June 4 (Reuters) – Thirteen people were
jailed on Monday for rioting in a Kazakh oil town, prompting
courtroom scuffles between relatives and police at the end of a
10-week trial that followed deadly labour unrest in the Central
Asian state.
Twenty four of the 37 defendants accused of rioting in the
town of Zhanaozen last December were freed by the court in the
western city of Aktau. Three were acquitted and the remainder
amnestied or given suspended sentences.
Relatives cram Kazakh court for riot trial verdict
AKTAU, Kazakhstan (Reuters) – Relatives of 37 protesters accused of rioting in a Kazakh oil town crammed into a makeshift courtroom on Monday to await the verdicts in the largest trial relating to the deadly December clashes.
The defendants stand accused of participating in riots that killed at least 14 people and saw police use live rounds. The violence posed the most serious challenge to President Nursultan Nazarbayev in more than two decades of power and shattered the Central Asian state's reputation for stability.
Five Kazakh policemen jailed over oil town clashes
ALMATY, May 28 (Reuters) – Five Kazakh policemen were jailed
for between five and seven years on Monday for abusing their
power during clashes between armed officers and striking oil
workers in the country's worst violence in decades.
At least 14 people were killed in the fighting that erupted
in the western oil town of Zhanaozen on Dec. 16 after a
seven-month strike by oilmen demanding higher wages spun out of
Six convicted over Kazakhstan oil riots – court
ALMATY, May 21 (Reuters) – Six people were convicted on
Monday for taking part in deadly labour riots in Kazakhstan that
were seen as a major challenge to the authority of President
Nursultan Nazarbayev.
Another six people were cleared of rioting during the two
days of violence that left at least 15 dead in December, court
officials said.


text:
Are you Malin von Otter?Claim your profile
Publications (11)46.5 Total impact
- SourceAvailable from: Elvira Valeria De Marco
Article: Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson s disease a multicenter study[Show abstract] [Hide abstract]
ABSTRACT: Background The transcription factor Nrf2, encoded by the NFE2L2 gene, is an important regulator of the cellular protection against oxidative stress. Parkinson¿s disease is a neurodegenerative disease highly associated with oxidative stress. In a previously published study, we reported associations of NFE2L2 haplotypes with risk and age at onset of idiopathic Parkinson¿s disease in a Swedish discovery material and a Polish replication material. Here, we have extended the replication study and performed meta-analyses including the Polish material and four new independent European patient-control materials. Furthermore, all SNPs included in the haplotype windows were investigated individually for associations with Parkinson¿s disease in meta-analyses including all six materials.Methods Totally 1038 patients and 1600 control subjects were studied. Based on previous NFE2L2 haplotype associations with Parkinson¿s disease, five NFE2L2 tag SNPs were genotyped by allelic discrimination and three functional NFE2L2 promoter SNPs were genotyped by sequencing. The impact of individual SNPs and haplotypes on risk and age at onset of Parkinson¿s disease were investigated in each material individually and in meta-analyses of the obtained results.ResultsMeta-analyses of NFE2L2 haplotypes showed association of haplotype GAGCAAAA, including the fully functional promoter haplotype AGC, with decreased risk (OR¿=¿0.8 per allele, p¿=¿0.012) and delayed onset (+1.1 years per allele, p¿=¿0.048) of Parkinson¿s disease. These results support the previously observed protective effect of this haplotype in the first study. Further, meta-analyses of the SNPs included in the haplotypes revealed four NFE2L2 SNPs associated with age at onset of Parkinson¿s disease (rs7557529 G¿>¿A, ¿1.0 years per allele, p¿=¿0.042; rs35652124 A¿>¿G, ¿1.1 years per allele, p¿=¿0.045; rs2886161 A¿>¿G, ¿1.2 years per allele, p¿=¿0.021; rs1806649 G¿>¿A, +1.2 years per allele, p¿=¿0.029). One of these (rs35652124) is a functional SNP located in the NFE2L2 promoter. No individual SNP was associated with risk of Parkinson¿s disease.Conclusion Our results support the hypothesis that variation in the NFE2L2 gene, encoding a central protein in the cellular protection against oxidative stress, may contribute to the pathogenesis of Parkinson¿s disease. Functional studies are now needed to explore these results further.BMC Medical Genetics 12/2014; 15(1):131. DOI:10.1186/s12881-014-0131-4 · 2.45 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron syndrome influenced by oxidative stress. The transcription factor Nrf2 and its repressor Keap1 constitute an important defence system in cellular protection against oxidative stress. Here we hypothesize that common genetic variations in the genes NFE2L2 and KEAP1, encoding Nrf2 and Keap1, may influence the risk and phenotype of ALS. Five hundred and twenty-two Swedish patients with sporadic ALS (SALS) and 564 Swedish control subjects were studied. Eight tag SNPs in NFE2L2 and three tag SNPs in KEAP1 were genotyped by allelic discrimination and three functional NFE2L2 promoter SNPs were genotyped by sequencing. One NFE2L2 haplotype (GGGAC) was associated with decreased risk of SALS (OR = 0.62 per allele, p = 0.003) and one haplotype in KEAP1 (CGG) was associated with later SALS onset (+3.4 years per allele, p = 0.015). When stratified by subgroup, one haplotype in NFE2L2, GAGCAGA including three functional promoter SNPs associated with high Nrf2 protein expression, was associated with 4.0 years later disease onset per allele in subgroup ALS (p = 0.008). In conclusion, these results suggest that variations in NFE2L2 and KEAP1, encoding two central proteins in cellular oxidative stress defence, may influence SALS pathogenesis.10/2013; 15(1-2). DOI:10.3109/21678421.2013.839708
- [Show abstract] [Hide abstract]
ABSTRACT: Alzheimer's disease (AD) is the most common neurodegenerative disease, and is clinically characterized by cognitive disturbances and the accumulation of the amyloid β (Aβ) peptides in plaques in the brain. Recent studies have shown the links between AD and the immediate-early gene Arc (activity-regulated cytoskeleton-associated protein), involved in synaptic plasticity and memory consolidation. For example, AD mouse models show a decreased expression of Arc mRNA in the brain. In additional, acute Aβ application to brain slices leads to a widespread ARC protein diffusion, unlike the normal defined localization to synapses. In this study, we investigated genetic variation in human ARC and the risk of developing AD. To this end, we genotyped 713 subjects diagnosed with AD and 841 controls without dementia. ARC was sequenced in a group of healthy individuals, and seven previously known SNPs and three novel SNPs were identified. Two of the newly found SNPs were intronic and one, +2852(G/A), was located in the 3'UTR. Three tag SNPs were selected, including the novel SNP +2852(G/A), to relate to risk of AD, Mini Mental State Examination (MMSE) scores and cerebrospinal fluid (CSF) biomarker levels of total tau (T-tau), hyperphosphorylated tau181 (P-tau(181)) and Aβ(1-42). The AA genotype of the newly found 3'-UTR SNP +2852(A/G), was associated with a decreased risk of AD (p (c) = 0.005; OR = 0.74; 95 % CI: 0.61-0.89). No associations of single SNPs or haplotypes with MMSE score or CSF biomarkers were found. Here we report a novel ARC SNP associated with a reduced risk of developing AD. To our knowledge, this is the first study associating a gene variant of ARC with any disease. The location of the SNP within the 3'UTR indicates that dendritic targeting of ARC mRNA could be involved in the molecular mechanisms underlying this protective function. However, further investigation of the importance of this SNP for ARC function, ARC processing and the pathology of AD is needed.Journal of Neural Transmission 05/2012; 119(7):833-42. DOI:10.1007/s00702-012-0823-x · 2.87 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Defective tissue regeneration is thought to contribute to several human diseases, including neurodegenerative disorders, heart failure and various lung diseases. Boosting the regenerative capacity has been suggested a possible therapeutic approach. Methods to metabolically label newly synthesized proteins in vivo with stable isotopic forms of amino acids holds promise for the study of protein turnover and tissue regeneration that are fundamental to the sustained life of all organisms. Here, we used the "stable isotope labeling with amino acids in cell culture" (SILAC) approach to explore normal protein turnover and tissue regeneration in adult zebrafish. The ratio of labeled and unlabeled proteins/peptides in specific organs of zebrafish fed a SILAC diet containing (13)C(6)-labeled lysine was determined by liquid chromatography and tandem mass spectrometry. Labeling was highest in tissues with high regenerative capacity, including intestine, liver, and fin, whereas brain and heart displayed the lowest labeling. Proteins with high degree of labeling were mainly involved in catalytic or transport activity pathways. The technique also verified increased protein synthesis during regeneration of the caudal fin following amputation. This newly developed SILAC zebrafish model constitutes a novel tool to analyze tissue regeneration in an animal model amenable to genetic and pharmacologic manipulation.Journal of proteomics 08/2011; 75(2):425-34. DOI:10.1016/j.jprot.2011.08.008 · 3.93 Impact Factor
- Alzheimer's and Dementia 07/2010; 6(4):e25. DOI:10.1016/j.jalz.2010.08.077 · 17.47 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The receptor for advanced glycation end-products (RAGE) has been implicated in several pathophysiological processes relevant to Alzheimer's disease (AD), including transport and synaptotoxicity of AD-associated amyloid beta (Abeta) peptides. A recent Chinese study (Li et al. in J Neural Transm 117:97-104, 2010) suggested an association between the 82S allele of the functional single nucleotide polymorphism (SNP) G82S (rs2070600) in the RAGE-encoding gene AGER and risk of AD. The present study aimed to investigate associations between AGER, AD diagnosis, cognitive scores and cerebrospinal fluid AD biomarkers in a European cohort of 316 neurochemically verified AD cases and 579 controls. Aside from G82S, three additional tag SNPs were analyzed to cover the common genetic variation in AGER. The 82S allele was associated with increased risk of AD (P (c) = 0.04, OR = 2.0, 95% CI 1.2-3.4). There was no genetic interaction between AGER 82S and APOE epsilon4 in producing increased risk of AD (P = 0.4), and none of the AGER SNPs showed association with Abeta(42), T-tau, P-tau(181) or mini-mental state examination scores. The data speak for a weak, but significant effect of AGER on risk of AD.Journal of Neural Transmission 07/2010; 117(7):861-7. DOI:10.1007/s00702-010-0437-0 · 2.87 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The model organism zebrafish (Danio rerio) is extensively utilized in studies of developmental biology but is also being investigated in the context of a growing list of human age-related diseases. To facilitate such studies, we here present protein expression patterns of adult zebrafish organs, including blood, brain, fin, heart, intestine, liver, and skeletal muscle. Protein extracts were prepared from the different organs of two zebrafish and analyzed using liquid chromatography coupled to high-resolution tandem mass spectrometry. Zebrafish tissue was digested directly after minimal fractionation and cleaned up (the shotgun approach). Proteins were identified using Mascot software. In total, 1394 proteins were identified of which 644 were nonredundant. Of these, 373 demonstrated an organ-specific expression pattern and 57 had not been shown on protein level before. These data emphasize the need for increased research at the protein level to facilitate the selection of candidate proteins for targeted quantification and to refine systematic genetic network analysis in vertebrate development, biology, and disease.Zebrafish 04/2010; 7(2):161-8. DOI:10.1089/zeb.2009.0644 · 1.77 Impact Factor
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ABSTRACT: Alzheimer's disease (AD) is characterized by protein aggregates, i.e. senile plaques and neurofibrillary tangles. The ubiquitin-proteasome system has been proposed a role in proteolytic removal of these protein aggregates. Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme with important functions in recycling of ubiquitin. The S18Y polymorphism of the UCHL1 gene confers protection against Parkinson's disease. In this study, the genotype and allele frequencies of the UCHL1 S18Y polymorphism were investigated in 452 AD patients and 234 control subjects, recruited from four memory clinics in Sweden. Using a binary logistic regression model including UCHL1 allele A and APOE epsilon4 allele positivity, age and sex as covariates with AD diagnosis as dependent variable, an adjusted OR of 0.82 ([95% CI 0.55-1.24], P = 0.35) was obtained for a positive UCHL1 allele A carrier status. The present study thus do not support a protective effect of the UCHL1 S18Y polymorphism against AD.Molecular Neurodegeneration 03/2010; 5:11. DOI:10.1186/1750-1326-5-11 · 5.29 Impact Factor
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ABSTRACT: Oxidative stress is heavily implicated in the pathogenic process of Parkinson's disease. Varying capacity to detoxify radical oxygen species through induction of phase II antioxidant enzymes in substantia nigra may influence disease risk. Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson's disease. The study included a Swedish discovery case-control material (165 cases and 190 controls) and a Polish replication case-control material (192 cases and 192 controls). Eight tag single nucleotide polymorphisms representing the variation in NFE2L2 and three representing the variation in KEAP1 were chosen using HapMap data and were genotyped using TaqMan Allelic Discrimination. We identified a protective NFE2L2 haplotype in both of our European case-control materials. Each haplotype allele was associated with five years later age at onset of the disease (p = 0.001) in the Swedish material, and decreased risk of PD (p = 2 x 10(-6)), with an odds ratio of 0.4 (95% CI 0.3-0.6) for heterozygous and 0.2 (95% CI 0.1-0.4) for homozygous carriers, in the Polish material. The identified haplotype includes a functional promoter haplotype previously associated with high transcriptional activity. Genetic variation in KEAP1 did not show any associations. These data suggest that variation in NFE2L2 modifies the Parkinson's disease process and provide another link between oxidative stress and neurodegeneration.BMC Medical Genetics 03/2010; 11:36. DOI:10.1186/1471-2350-11-36 · 2.45 Impact Factor
Article: Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract.[Show abstract] [Hide abstract]
ABSTRACT: Alzheimer's disease (AD) and age-related cataract, disorders characterized by protein aggregation causing late-onset disease, both involve oxidative stress. We hypothesize that common variants of NFE2L2 and KEAP1, the genes encoding the main regulators of the Nrf2 system, an important defence system against oxidative stress, may influence risk of AD and/or age-related cataract. This case-control study combines an AD material (725 cases and 845 controls), and a cataract material (489 cases and 182 controls). Genetic variation in NFE2L2 and KEAP1 was tagged by eight and three tag single nucleotide polymorphisms (SNPs), respectively. Single SNPs and haplotypes were analyzed for associations with disease risk, age parameters, MMSE and AD cerebrospinal fluid biomarkers. NFE2L2 and KEAP1 were not associated with risk of AD or cataract. However, one haplotype allele of NFE2L2 was associated with 2 years earlier age at AD onset (p(c)=0.013) and 4 years earlier age at surgery for posterior subcapsular cataract (p(c)=0.019). Another haplotype of NFE2L2 was associated with 4 years later age at surgery for cortical cataract (p(c)=0.009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset.Mechanisms of ageing and development 02/2010; 131(2):105-10. DOI:10.1016/j.mad.2009.12.007 · 3.51 Impact Factor
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ABSTRACT: A functional intracellular transport system is essential to maintain cell shape and function especially in elongated cells, e.g. neurons and lens fibre cells. Impaired intracellular transport has been suggested as a common pathological mechanism for age-related diseases characterised by protein aggregation. Here, we hypothesise that common genetic variation in the transport protein kinesin may influence the risk of Parkinson's disease (PD), Alzheimer's disease (AD) and age-related cataract. This case-control study involves a PD material (165 cases and 190 controls), an AD material (653 cases and 845 controls) and a cataract material (495 cases and 183 controls). Genetic variation in the kinesin light chain 1-encoding gene (KLC1) was tagged by six tag single nucleotide polymorphisms (SNPs). Single SNPs and haplotypes were analysed for associations with disease risk, age parameters, mini-mental state examination scores and cerebrospinal fluid biomarkers for AD using logistic or linear regression. Genetic variation in KLC1 did not influence risk of PD. Weak associations with risk of AD were seen for rs8007903 and rs3212079 (P (c) = 0.04 and P (c) = 0.02, respectively). Two SNPs (rs8007903 and rs8702) influenced risk of cataract (P (c) = 0.0007 and P (c) = 0.04, respectively). However, the allele of rs8007903 that caused increased risk of AD caused reduced risk of cataract, speaking against a common functional effect of this particular SNP in the two diseases. Haplotype analyses did not add significantly to the associations found in the single SNP analyses. Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract.Neuromolecular medicine 11/2009; 12(3):229-36. DOI:10.1007/s12017-009-8103-0 · 3.89 Impact Factor
Top Journals
University of Gothenburg
Goeteborg, Västra Götaland, Sweden
- Department of Psychiatry and Neurochemistry


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- Rare San Remo conversion by Coach Design Group, Inc. for Hillcrest Motor Company in Beverly Hills, California- Comprehensive restoration- 350 CI engine- Automatic... More
1978 Cadillac Seville, I am the third owner. I've had this car since 2003, and have enjoyed every minute of it. It is not... More
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ROOTED in PEACE is the personal story of GREG REITMAN who relives his past experiences of war and pursues finding peace in our world.
GREG REITMAN "The Green Conscious Filmmaker"
Greg Reitman is the founder of BLUE WATER ENTERTAINMENT, INC, an independent production company focusing on environmentally conscious entertainment. Widely regarded as Hollywood's "Green Producer," Greg Reitman produced the 2008 SUNDANCE Audience Award-winning feature documentary "FUEL (CNBC)." He wrote, produced, and directed the feature documentary "HOLLYWOOD'S MAGICAL ISLAND- CATALINA" (2003), syndicated on American Public Television (APT), and returned in 2010 on KCET for national pledge syndication. Greg Reitman is currently in post-production on his new feature documentary film, "ROOTED in PEACE."
Greg is a green correspondent for "The Environmentalist" a leading online news agency that focuses on green issues and trends in the geopolitical marketplace. Recently, Greg was written up in Movie Maker Magazine as one of the top ten producers in the Entertainment industry making content that makes a difference in the world.
Greg Reitman lives a "green lifestyle" in Los Angeles.


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The Reid Report 05/06/14
Ohio law cuts early voting days
Ohio Sen. Nina Turner joins Joy Reid to discuss a new voting law in Ohio that may limit the number of early voting days and registration days. Plus, a look at the North Carolina primary race. ... more Duration: {{video.duration.momentjs}}
Ohio law cuts early voting days
Joy Reid signs off on The Reid Report
House of Cards season 3 release is here!
Rep. Marcia Fudge on pending DHS shutdown
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The Used AmeriGlide Ultra Stair Lift uses the always reliable rack and pinion drive system, that offers a safe, smooth ride for every trip up or down your home's stairs. With the Used AmeriGlide Ultra, you will enjoy the "Soft Start" and "Soft Stop" technology that ensures a smooth ride from start to finish. The DC battery allows you to make a trip up or down the stairs, even during a power outage. The innovative design of this amazing looking stair lift will fit into your home just as any other piece of furniture would.
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Image Resources | Currently on View in William L. Fortune Gallery
The child's serious expression reflects the mid-19th century concept of children as small adults.
The rugged setting is a reminder of the frontier conditions that existed in Indiana in the 1850s.
Hegler received a commission from Dr. Lewis Lyons of Attica to paint his daughter Alice.
Purchased by Roger Gould Wolcott at an auction in 1951 where the contents of the Lyon's home were sold in Attica. Records state that it was in the collection of Minnie Parker of Attica.


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Human trafficking of youths is taking place in Jefferson County, Lynn Johnson, Jeffco's human services director, told a town hall meeting in Evergreen last Thursday.
Johnson said boys and girls ages 5 to 18 are being kidnapped, raped, punished and beaten by sex traffickers who coerce them into prostitution.
"It's all about vulnerable populations. … It is a large industry that is going to take an army to stop," Johnson said.
Whether you were shopping for a luxury home or simply seeing how the other half lives, Evergreen's inaugural Parade of Luxury Homes was a success.
More than 2,400 people made their way through eight homes — three near Upper Bear Creek, three in the Soda Creek area and two near El Rancho — viewing sumptuous houses with manicured lawns and eclectic art.
Two male juveniles have been arrested in connection with recent burglaries at Olde's Shell station, the Stagecoach Sports Grill and Taco Bell in Evergreen, sheriff's spokesman Mark Techmeyer reported Thursday afternoon.
The two teens also could be suspects in a series of break-ins in the mountain area in recent weeks, Techmeyer said.
More than 100 people had signed up to find out more about cannabidiol at a meeting put together by Ambary Gardens LLC in Kittredge.
The public meeting is slated for 6:30 p.m. Thursday at the Evergreen Elks Club, 27972 Iris Drive. Two lobbyists, a U.S. Army veteran and a brain injury researcher are scheduled to talk about the benefits of hemp and cannabidiol at the meeting.
Kai Bianco is a little boy with a lot of personality.
Kai, who was bitten in the head by the family dog last year, turned 2 on May 24. While he is still behind developmentally, Kai acts pretty much like a 2-year-old should. He plays with his trucks — he calls them "go-gos" — and loves to sing, pose for photos and wave bye-bye. He knows what he wants and goes after it.
He's a strong-willed little boy. He's a fighter.
A family's love for their deceased father and husband, as well as a lifelong friendship between two golfers, has meant big benefits for area high school students in recent years.
With help from the Bob Beaty Foundation scholarships, many of those students have graduated from college and are out in the working world.
Several members of the Aktion Club of Blue Spruce Kiwanis are planning to participate in the celebratory walk across the new connector trail leading to Evergreen Lake on June 3.
The Geezers Racing Team of Evergreen is dedicating this season's races to raising funds to support the Special Needs Program of the Evergreen Park and Recreation District.
The team's first 12-hour endurance race is scheduled for June 6 at the High Plains Raceway in Byers, said Dan Smith, one of six drivers in the competition. He and the others on the team will take turns driving a rebuilt 1984 Toyota Corolla that is sporting a new motor. Other upcoming races are scheduled in July and September.
The club, organized by Kiwanis members four years ago, is a group of adults with disabilities who live in Evergreen and nearby mountain communities. Participants in the organization work on service projects in the community, including a recent one in which they helped build a playground at Marshdale Elementary School.
Standing before a group of recent high school graduates, veteran journalist Greg Dobbs advised them to follow their dreams at a baccalaureate service on Sunday afternoon.
"I want to tell you how great your lives can be, if you will dream," Dobbs said. "If you dream, there's a chance your dream will come true."
During his career as an international television correspondent, a youthful dream of traveling came true, Dobbs said. His work involved both rewards and hardships, he added.
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