text:
- Simone "Simca" Beck born (1904)
12 Most Ridiculous Beer Names
Today on The Daily Meal
Recipe of the day
The craft beer industry is serious about making good beer. But save for that all-important and unwavering goal, it's doubtful that the word "serious" would find its way onto the industry's would-be "About Me" page.
Craft beer is about unbridled experimentation and stand-out-in-the-crowd personality. The suds themselves make that abundantly clear — just consider the creative reimaginings of Belgian-style brews, bold session sippers, and IPAs of all colors and varying degrees of mouth-puckering bitterness stocking today's shelves. And the originality is also apparent in the colorful, clever, and sometimes cartoonish labels that transform your local store's beer aisle into a veritable art gallery.
But perhaps the best display of the industry's sense of humor and edge — or at the very least, the most amusing — can be found in the names some brewers have chosen to give their creations. Ranging from cheeky and borderline inappropriate to clever turns of phrase and just plain ridiculous, these beer names are definitely good for a laugh.
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Experimental comparison of parameter estimation methods in adaptive robot control
Berghuis, Harry and Roebbers, Herman and Nijmeijer, Henk (1995) Experimental comparison of parameter estimation methods in adaptive robot control. Automatica, 31 (9). pp. 1275-1285. ISSN 0005-1098
|In the literature on adaptive robot control a large variety of parameter estimation methods have been proposed, ranging from tracking-error-driven gradient methods to combined tracking- and prediction-error-driven least-squares type adaptation methods. This paper presents experimental data from a comparative study between these adaptation methods, performed on a two-degrees-of-freedom robot manipulator. Our results show that the prediction error concept is sensitive to unavoidable model uncertainties. We also demonstrate empirically the fast convergence properties of least-squares adaptation relative to gradient approaches. However, in view of the noise sensitivity of the least-squares method, the marginal performance benefits, and the computational burden, we (cautiously) conclude that the tracking-error driven gradient method is preferred for parameter adaptation in robotic applications.
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Woman's mummified remains were in her home since 2003
The woman who kept her mother's mummified remains in a bedroom of their home for six years told police she never reported the death because she couldn't afford burial expenses.
According to interview records released Tuesday, Penelope Sharon Jordan maintained the ruse over the fate of Timmie Jordan since 2003. The story she gave to a Sebastian officer Monday morning was that her mother, born in 1913, was living in Melbourne. However, officers said Penelope Jordan couldn't provide an address.
The officers said they discovered the remains when she allowed them inside her Wimbrow Drive home. Timmie Jordan's decaying body was found on a bed in a cluttered bedroom.
The 61-year-old day care teacher told police her mother died from old age in 2003, according to interview records. An autopsy performed Tuesday showed no evidence of foul play, police spokesman Steve Marcinik said. the coroner will attribute Timmie Jordan's death to natural causes, Marcinik said.
Penelope Jordan admitted to continuing to collect her mother's Social Security checks past her reported death, according to the police interview. Detectives charged her with grand theft and fraud. The government mailed $800 checks to the Jordan home monthly, totaling $60,000 since 2003, the arrest affidavit said.
Police said Timmie Jordan's death may have remained secret because there were no other immediate family members nearby.
"We're aware of a sister of Penelope's who lives in Africa," Marcinik said. "I'm told she has been notified."
Many of the neighbors moved into their homes in the six years since Timmie Jordan's unreported death. Others, such as Theda Furtado, have lived there for decades and recalled the Jordans as keeping to themselves.
"We moved in 31 years ago, and they were always very standoffish," Furtado said. "They had a tall chain link fence around their property for a while."
Authorities were alerted to the Jordan home after a complaint about nuisance cats. Indian River County Animal Control manager Jason Ogilvie said his officers have been called to the neighborhood several times a year to trap cats there.
"(Penelope Jordan) always denied the cats were hers," Ogilvie said. "But our officer saw eight of them on her front door step Friday."
The front door to the home was open, but no one was home. Animal control officers called police to check if there had been a burglary, Ogilvie said.
Jordan was being held in lieu of $20,000 bail Tuesday at the Indian River County Jail.
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DTE Energy smart meter lead punches back, complains about news story
In a letter to the editor titled "Advanced meters are the future," the manager of DTE Energy's advanced metering program complains about an April 12 story in the Detroit News. Bob Sitkauskas claims the piece "contained numerous mischaracterizations about DTE Energy's advanced utility meter program and failed to point out the many benefits the meters will provide to our customers."
The story reported that a Michigan Court of Appeals had overturned a recent rate increase, sending it back to the Public Service Commission for review. "The Court of Appeals did not reject the costs or say they were improper," Sitkauskas argues. "We anticipate that the program will be seen as a great investment that is bringing numerous benefits to our customers."


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Savory Butter Scones
|Self rising flour
|2 Cup (32 tbs)
|Baking powder
|1 Teaspoon
|1⁄2 Teaspoon
|2 Tablespoon
|1⁄2 Cup (8 tbs), grated
|1 (Canned)
|1 Small, finely chopped
|1 Clove (5 gm), crushed
|Chopped parsley
|1 Teaspoon
|1⁄4 Cup (4 tbs) (Approximately)
|1⁄3 Cup (5.33 tbs), melted
1)In a large mixing bowl sift the self-raising flour, baking poweder and salt.
2) Add the butter in cut pieces to make the dough flakey and crumby.
3) Mix the remaining ingrediants - cheese, pimento, onion, garlic, and parsley into the mixture.
4) Slowly add the milk as required to make a soft and non-sticky dough.
5) Take a baking an 8 inche baking dish and line it with waxing or baking paper.
6) Pour the dough mixture into the baking dish and smoothen well.
7) Allow the dought the bake in the oven at the "simmer" setting for seven minutes and then switch to the highest setting for the last 3 to 4 minutes. The dough will have risen and cooked by now.
8) Once the ready, remove from the oven , and pour the 1/3 cup melted butter over the baked dough. Keep aside for 5 minutes allowing the butter to seep into the bake.
9) Once cooled, cut into 1.5 x3 inch size bites/ fingers and serve hot.
10) It serves as a great evening snack with a hot cup of coffee or tea


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Online Shop osCommerce Template 10959
osCommerce 2.2 Template that was composed by our webmaster artist Delta.
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Description, Sources, Software & Requirements
Summer clothing template with an open and simple theme for displaying flip flops, shirts, shorts, bathing suits, sporting wear, bikinis, and light clothing. The template has a white background with gray and green accents along with gray and red text. The header has a blue banner image on the left with a woman in a black shirt and jeans and to the right there is a green banner image with a man in skiing goggles. Online Shop osCommerce Template 10959 is available in the following sources: .PSD, and .PHP. Software required includes Winzip 9+ (Windows) or Stuffit Expander 10+ (Mac) for uncompressing .zip files, Adobe Photoshop CS+, Hosting with PHP4x and MySQL4x, osCommerce runs on most server specific configurations ranging from dedicated servers to shared servers that utilize different PHP configurations such as register_globals (should be ON) and safe_mode restrictions, Adobe Dreamweaver 8+ (or any php-editor), and Apache Only (on Unix/Freebsd/Linux/Windows). It has had a total of total of 3 downloads since it first appeared.


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It Is Better to Give than It Is to Receive
One element of my IEEE Standards Association (SA) volunteer activities is to represent the SA to the IEEE New Initiatives Committee (NIC). In December, the group gets together face-to-face to review projects underway and to approve new projects for the next year. The new initiative program is designed to identify potential new products, programs, and services that will provide significant benefit to IEEE members, customers, the technical community, the public, which promises to have a lasting impact on the IEEE.
Initiatives are of strategic importance and must demonstrate a clear benefit to IEEE. The process allows submission of a proposal at any time during the year, not just in December.
The IEEE SA worked with the NIC several years back to help it study and launch a Patent Pools project to expand possible IEEE standards business to facilitate faster adoption of standards where patent use is needed to implement a standard and a patent pool could help.
While the NIC has supported programs that facilitate standards use, new initiatives run the gamut of global IEEE interests. One project with several years of support that has had an impact on humanity is the IEEE Humanitarian Technology Network (HTN). A map of global projects is maintained that shows all going on around the world.
Any IEEE member, volunteer or IEEE organizational unit can submit a proposal. Do you have a new initiative idea for the IEEE? If so, you might want to submit your idea to the NIC for consideration.
Overview of the IEEE New Initiative Program
IEEE new initiative proposals are submitted using one of two submission processes.
- The New Initiative Process (NIP) is for projects that require a minimum of US$100,000 funding for the first year.
Download IEEE New Initiatives Proposal Form (DOC, 229 KB)
- The Seed Grant Process (SGP) is for projects that are experimental and innovative and require US$25,000 of funding or less. Download IEEE New Initiatives Seed Grant Proposal Form (DOC, 71 KB)
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This blog will provide an online forum to provide weekly updates on concepts, values, standards, methodologies and examples to assist with the understanding of what advanced functional verification technologies can do and how to most effectively apply them. We're looking forward to your comments and suggestions on the posts to make this a useful tool. Verification Horizons BLOG
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Nationwide Career Events - Los Angeles Job Fair
- Business & Professional
- 5400 West Century Blvd, Los Angeles, CA, 90045
Century 21 Masters presents Mike Ferry
Tuesday, May 7, 2013 at 9:00 AM (PDT)
5 Things You Can Do Now to Get Listings in This Market
For more than 35 years, The Mike Ferry Organization has been committed to providing Real Estate professionals with the very best in sales training and coaching. If you are a Real Estate agent wanting to enhance your skills, increase production, and improve profitability, then this is the event for you!
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What is Echinacea and why is it so AMAZING? Echinacea is a type of coneflower. It is a very powerful herb that can help you to boost your immune system. Boosting your immune system if very … [Read more...]
Cinnamon Bark Oil: Natural Antiviral
Did you know that cinnamon bark oil can help boost your immune system naturally? Cinnamon bark can help with the following: * Antiviral * Natural immune booster * Aids in weight loss * Promotes … [Read more...]
Is Coffee Bad For You?
I know everyone loves a good cup of coffee! So do I! I get asked all the time "Is coffee okay to drink?" Well, the short answer is this: In moderation coffee is fine. … [Read more...]
Natural Remedies: Lemon Ginger Tea!
This is a POWERFUL tea that is incredibly easy to make! This is what you will need: * Fresh Ginger Root * 1 Lemon (washed) * 1 Garlic Clove (optional) * Fresh Honey Take 1" of the ginger root … [Read more...]
Clear out the brain fog!
Have you ever been stuck in a rut? Like you have brain fog and just lack motivation? I think we have all been there at one point or another. Sometimes it can be especially difficult to clear the … [Read more...]


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By MAGGIE MAY
from AJAX
Although somewhat sheer, I purchased this item in the black, and with a black bra, it looks just fine. Better than fine, in fact. I love the bubble-knit fabric. This, along with the style, results in a sophisticated look you can dress up or down. Moreover, I am so thankful that your size range extends to XS. So few of tsc's lines extend to XS and only one that I'm aware of has an XXS--something that would be great if you would consider in future. We small people need clothes too! Thanks to Joey for this lovely top and tsc for bringing this line to us.
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looks way better on t.v. and in pic.
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The fabric is extremely thin, flimsy, and this top has no substace to it - see though, almost like cheese cloth. Returned.
Bottom Line No, I would not recommend this to a friend
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Very nice top!
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Love the bubble effect of the material and the taupe color is pretty. Would have given it 5, except it's just slightly see through and I don't like to wear camis, but I can still get away with it, by wearing a nude bra. Enjoy the 3/4 sleeves and once again, the fact it's made in Canada!


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Ryan Dempster runs scoreless streak to 33 innings in win over Diamondbacks
Jul 14, 2012, 4:18 PM EDT
Ryan Dempster continues to do wonders for his trade value. In his second start back after missing three weeks with a strained right lat muscle, Dempster tossed six shutout innings this afternoon as part of a 4-1 win over the Diamondbacks at Wrigley Field. He now has a career-high 33-inning scoreless streak dating back to May 30 against the Padres.
Dempster's scoreless streak is the longest in the majors this season, topping R.A. Dickey's 32 2/3 inning streak from May 22-June 13. It's also the longest scoreless streak by any Cubs' pitcher since Ken Holtzman had a 33-inning scoreless streak of his own back in 1969.
Dempster, an impending free agent, currently leads the majors with a 1.86 ERA and has a solid 75/25 K/BB ratio across 92 innings. The 35-year-old has earned ten-and-five rights, so he has the ability to block any trade, but he has indicated that he's willing to accept a deal in the right situation. The Dodgers have been mentioned frequently as a potential suitor.
- redguy12588 - Jul 14, 2012 at 4:31 PM
A good rental player is still a rental player. The dodgers wouldn't even get a comp pick for him. I can't see him being worth any teams top 10 prospect.
- paperlions - Jul 14, 2012 at 5:25 PM
For most organizations, he's worth any of their top 4-10 prospects….most of those guys will never be MLB regulars. He isn't worth a top 50 overall prospect….those guys have a decent combo of ceiling and likelihood of reaching it….but for a team that needs pitching, he's probably worth just about any other prospect.
- proudlycanadian - Jul 14, 2012 at 4:35 PM
He is 35. He is a rental. He is having a great year. He should still get the Cubs a couple of devent prospects.
- redguy12588 - Jul 14, 2012 at 5:15 PM
Rentals aren't worth as much anymore with the new CBA.
- bigleagues - Jul 14, 2012 at 6:14 PM
Another way to look at this is perhaps "rentals" are less likely to happen . . . and that the Cubs will seek to trade Dempster to a team that Dempster feels comfortable signing with.
Which is likely why there have been reports of Theo having very public conversations with Dempster about the status of potential deals.
- proudlycanadian - Jul 14, 2012 at 6:37 PM
Good point.
- proudlycanadian - Jul 14, 2012 at 7:40 PM
bigleagues is implying that the team that gets Dempster will also have to negotiate a new contract with him. One other consideration that points to that outcome is that Dempster probably wants to have a contract in place prior to pitching for Canada in the World Baseball Classic. A contract would protect him in case of an injury in the WBC.
- bigleagues - Jul 14, 2012 at 10:44 PM
ALSO a good point.
- randygnyc - Jul 14, 2012 at 5:04 PM
Yankees should take him for a few months. In need of a 5th starter.
- hoopmatch - Jul 14, 2012 at 5:52 PM
At 35, he's not likely to get a huge free agent contract, so any team that "rents" him should have a decent chance of signing him for two or three years. It's not like trading for Hamels or Greinke.
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Japan seeks budget boost for expansion of military
Posted: August 30, 2014 at 3:04 a.m.
TOKYO -- Japan's Defense Ministry on Friday requested money for F-35 stealth fighter jets as part of its biggest-ever budget to bolster its ability to defend remote southern islands, including ones also claimed by an increasingly assertive China.
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Welcome to the Stitch Craft Create Online Fabric Shop. Here you will fabric designers such as Amy Butler, Tula Pink, Kaffe Fassett and Tilda! All of our fabrics are 100% Cotton and are suitable for all your handmade projects! Look out for our Fat Quarter Bundles which are great for boosting your fabric stash!
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text: http://www.daniweb.com – hey there, I have the following code: import java.awt.*; import javax.swing.*; public class TabelaEShahut extends JPanel{ public static void main(String[] args){ new TabelaEShahut(); } public TabelaEShahut(){ JFrame f = new JFrame(); f.setSize(500, 500); f.setVisible(true); f.setTitle("shah"); f.getContentPane().add(this); } public void paintComponent(Graphics g){ g.setColor(Color.white); g.fillRect(0, 0, 700, 700); g.setColor(Color.red); g.fillRect(50, 50, 400, 400); g.setColor(Color.black); g.fillRect(150, 50, 100, 100); g.fillRect(350, 50, 100, 100); g.fillRect(50, 150, 100, 100); g.fillRect(250, 150, 100, 100); g.fillRect(150, 250, 100, 100); g.fillRect(350, 250, 100, 100); g.fillRect(50, 350, 100, 100); g.fillRect(250, 350, 100, 100); } } I expected this code to work properly and display a four by four chess board on my screen... and it did, indeed, but the problem is that it does not do so everytime i run the code. i can never know if it is going to output the result or not when i run it. initially, it refused to show the board like twenty times but i kept comparing the code with other files i have that i know to have worked and comipling and running the file in question and it suddenly started working - but not everytime i run it. i was wondering what would the problem be and if there is any way i can prevent such unpredictabilities from occuring. you might need to know that i used jGRASP to compile and run the file. thanks a lot to anybody that replies and accept my apology for my long explanations. (General)


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Bentonville Advertising, Promotion Commission Eyes Future Convention Center
Posted: August 29, 2014 at 1:30 a.m.
BENTONVILLE -- Creating a convention or expo center in the city is a priority for the Bentonville Convention and Visitor's Bureau over the coming years, Advertising and Promotion commissioners discussed Thursday.
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Hi new to this but wanting to share some of my experiences with you all and hopefully I can aim to either help out others on EP with advice, support or just understanding to their experiences.
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Who are you to me? A stranger in my midst who I find so fascinating and interesting and yet when I'm with you it feels like I've known you forever. Your like a movie, where it's so damn interesting, I... [more]
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To All You Beautiful Scorpio Girls Her eyes sparkle and glitz like diamonds. They glare with such intensity that you can almost feel the heat from the fire blazing within. They lock you with a force so deep that your eyes cannot look a… [more]
I Believe That Love Comes UnexpectadlyLove Happens In Mysterious Ways I believe that love comes in many diffrent arrays in forms. From the unexpected hug in the morning from your moody teenage daughter who never use to hug you from time to time, to the neighbour next do… [more]
True Scorpio Girl I find myself being true to my sign, I swear I've read many accounts on my sign and it describes me in full detail. The intensity we tend to have but not show for fear of being looked down upon. The s… [more]
I 've Been In Love And BetrayedJackal And Hyde I really thought you were the one, but I guess I was wrong. I feel a bit decieved and used. I kind of thought I was with a conn. But we go through life thinking that everything is all good and fine an… [more]


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Does anxiety over what some fundamentalists believe is the coming "biblical apocalypse" motivate Republicans to vote for a particular candidate? According to a recent op-ed published in the New York Times, the answer is yes. The author of the piece, Matthew Avery Sutton, is an associate professor of history at Washington State University and is the author of Aimee Semple McPherson and the Resurrection of Christian America. In his article, Sutton claims that a "small but vocal minority" of Republicans associate the recent economic crises, the rise of "radical Islam," and diverse natural disasters with the "last days" of the earth and as such they are searching for the candidate they believe will lead them safely through this eschatological maelstrom.
How does religion, particularly the branch of Christianity called "fundamentalism," influence presidential politics? According to Sutton:
Christian apocalypticism has a long and varied history. Its most prevalent modern incarnation took shape a century ago, among the vast network of preachers, evangelists, Bible-college professors and publishers who established the fundamentalist movement. Baptists, Methodists, Presbyterians, Pentecostals and independents, they shared a commitment to returning the Christian faith to its "fundamentals."
A Louisiana woman suffering from cystic fibrosis is being hailed throughout the world for her decision to deliver three healthy triplets, rather than abort them as doctors had advised her. Identical triplets Dakota, Savannah, and Brooklyn recently celebrated their first birthday because their mother, 21-year-old Kandace Smith, refused to "terminate" them as she was counseled by her doctors, who told her "she was too small and weak to bear even one child, much less triplets," reported Beliefnet.com.
Cystic fibrosis is a serious hereditary disorder that affects the lungs, making it difficult to breathe and often leading to early death. Smith was told that she would likely never be able to have children. "I couldn't believe that I was actually pregnant," she recalled to the British newspaper the Daily Mail, "and when the scan showed there were three heartbeats I nearly passed out. I didn't actually believe it was possible — and there were three babies in my womb."
House Speaker John Boehner (R-Ohio) and other House leaders paid tribute to Rep. Charlie Rangel (D-N.Y.) on September 22, despite the fact that he was overwhelmingly censured by the House less than a year ago for ethics violations and has a history of courtship with Soviet and Communist subversive activities.
In December 2010, when the House was controlled by the Democratic majority of the 111th Congress, Democrats and Republicans overwhelmingly voted 333-79 to censure Congressman Rangel with regard to unpaid taxes on property he owned in the Dominican Republican, other hidden assets, and for improper use of the his campaign office to raise funds for the Charles B. Rangel Center for Public Service at the City College of New York — all of which are clear violations of House rules.
Congressional leaders, Minority Leader Nancy Pelosi (D-Calif.), Minority Whip Steny Hoyer (D-Md.), Senator Charles Schumer (D-N.Y.), Senator Kirsten Gillibrand (D-N.Y.), and Speaker of the House John Boehner still felt it prudent to honor the former head of the Ways and Means Committee with a special reception and the unveiling of a portrait in the Longworth House Office Building.
An aged Roman Catholic priest who offered objective moral truth to his parishioners has been relieved of his office. Bishop Valery Vienneau of the Diocese of Bathurst, in New Brunswick, Canada, removed Eudist Father Donat Gionet from his ministry because he gave sermons about homosexuals, abortion, and fornication, clearly enunciating Roman Catholic teaching on the subjects.
Nervous church authorities, under pressure from "the community," cashiered Gionet because he was not "sensitive" enough in articulating the faith.
So because of the "community," Gionet says he must now celebrate Mass in secret.
Stop the Sin
Gionet's trouble arose, LifeSiteNews.com reported, from his homilies in August, during which he denounced three of the key issues facing the Catholic church: abortion, fornication, and homosexuality. Even worse, he did so on the weekend of the local "pride" march. "Pride" is a word homosexuals use to describe their festivals and other public gatherings.
It became official three days ago. The military ended its ban on homosexuals serving "openly," meaning members of the armed forces may speak openly about what Lord Alfred Douglas referred to as the "Love That Dare Not Speak Its Name."
Homosexuals have now conquered the target-rich environment the military is for them, and the Marines, the most macho and gung-ho of the services, seem to have taken the mission to integrate homosexuals as seriously as the landing at Peleliu in 1944.
Marine recruiters, the New York Times reported, landed at a "gay community center" seeking recruits. In Tulsa, Oklahoma (home of Oral Roberts University), of all places.
Flower Power
The Times reported that the Marine foray into foreign territory is the Devil-Dog way of trying to be best at something:
In yet another example of liberal intolerance, big companies across the nation are being targeted by those on the Left for their affiliations with Christian groups that are opposed to gay marriage.
The Blaze explains: "Massive retailers like Apple, Microsoft, Netflix and Wal-Mart have a relationship with an Internet marketer called the Charity Giveback Group (CGBG). When CGBG brings customers to retailers' web sites, the marketer gets commission for the sales that are made. This, of course, is a common occurrence in the e-commerce world.... A portion of the commission that retailers pay out is donated to the buyers' charity of choice. On the list of potential recipients are Christian organizations like the Family Research Council and Focus on the Family — groups that oppose gay marriage."
The New York Times reports further: "The national battle was ignited in July by Stuart Wilber, a 73-year-old gay man in Seattle. He was astonished, he said, when he learned that people who bought Microsoft products through a Christian-oriented Internet marketer known as Charity Giveback Group, or CGBG, could channel a donation to evangelical organizations that call homosexual behavior a threat to the moral and social fabric."
Concerned that their group's name may sound too "regional" for effective outreach throughout the U.S., officials of the 166-year-old Southern Baptist Convention (SBC) have announced a task force assigned to study the possibility of changing the name of the 16.16-million member evangelical Christian denomination, the nation's largest. "Starting a church in New York, or Boston, or Minneapolis, or Cheyenne, Wyoming, it's really a barrier to a lot of folks in even considering that church or that ministry," SBC President Bryan Wright told Christianity Today. "When they hear Southern Baptist, it's a regional perception there. The reason this task force has been set up to study a possible name change is [firstly] to consider a name that is not so geographically limiting, and secondly to help us be better prepared for reaching North America for Christ in the 21st century."
It is not the first time the SBC has looked into changing its distinctive label. "Motions to study a name change have been presented to the convention on numerous occasions," reported the SBC's own Baptist Press News, "for example, 1965, 1974, 1983, 1989, 1990, and 1998." Additionally, a proposed "straw poll" to consider a name change was defeated at the SBC's annual meeting in 1999, and an effort in 2004 to put a study in motion was also shot down.
Nearly all the pundits and attorneys are calling Jaycee Lee Dugard's federal lawsuit a "long shot." Ms. Dugard, who was abducted with a "stun gun" on her way to school at age 11, then raped and tortured in a shed for 18 years by a federally paroled sex offender with the help of his also-released inmate wife, sued the federal government September 22, citing "gross neglect."
Even though the Dugard family received a $20-million settlement in 2009 through the California's Victims' Compensation Fund, Jaycee Dugard wants to send a message to federal officials and parole agents who "failed on numerous occasions to properly monitor" Phillip Garrido, her captor, a criminal with a history of drug abuse and violence dating back to 1976, when he abducted a woman from the Tahoe area and took her across state lines to Reno, Nevada, and raped her.
Any proceeds from the lawsuit, says Dugard, will go to her private charity, the JAYC Foundation, which assists families recovering from abduction and other trauma. She has quite enough money now, after all. It's her childhood she can't recover — and the welfare of two children conceived in rape, whom she still nurtures.
Activists protesting Utah's opposition to same-sex "marriage" (and other statutes dealing with moral issues) have found an effective way to garner public attention: stripping down to their underwear and running through the streets of Salt Lake City. Nate Porter, who planned the so-called Undie Run, said the goal of the event was to organize those frustrated by what he dubbed "uptight" laws in Utah.
He continued, "My goal is to change Utah. To make this state lighten up once and for all. I'm trying to draw people in that are jaded by [the state's] politics."
According to the Undie Run website, residents of Utah are boring and uptight, and it is the job of the protesters to change that. The site states,
We want each group of friends to come with there [sic] own specific demands written all over your body/undies/signs. Be creative. Get your friends to come with matching undies and help protest for your particular issues. Help us get the message out that Utah needs to lighten up. The Beauty of this event is that it's for you [to] decide. If you check the comments below you will see many voicing there [sic] opinions in many areas that Utah needs to simply lighten up on.
The Michigan legislature facilitated a huge pro-life victory September 21 when the state Senate voted 29-8 to ban late-term, "partial-birth" abortions. That vote followed an earlier 75-33 vote in the state House to approve the measure, which now heads to the desk of Republican Governor Rick Snyder for his expected signature.
A partial-birth abortion entails having an abortionist partially deliver a viable baby, and then kill the child before he or she completely emerges from the womb — making the procedure, by legal reasoning, an abortion rather than a homicide. The ban would make the procedure a felony punishable by a two-year prison term and a $50,000 fine.
Republican Senator Arlan Meekhof, one of the bill's sponsors, called partial-birth abortion "a barbaric act that we need to stop. I'm proud to sponsor this measure because I believe every life is precious.


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31 year old woman | Mission Hills, CA, USA | Seeking men 30-40 within 50 miles
Active within 3 days
I am by nature a dealer in words, and words are the most powerful drug known to humanity" RK
I am here to try out social dating… I am looking for someone who is very passionate (and please not on the first date!), respectful, knows what he wants and is a go-getter; someone who is sociable with good sense of humor. Life is too short and I don't want to even waist a minute of my life in the company of someone dry. I don't like uptight and stingy people. Please don't get this wrong… I am not a gold digger. I have always been independent and worked hard for myself. I just believe life is too short and you ought to enjoy it to the fullest. I am a very outgoing person and like to try new adventures. I like to take care of myself to the fullest; from head to toe. I like when men do so, too. I HATE arrogant, shallow, cocky, and full of BS people. Honesty is the only policy with me…. So please do not lie about your age, career, likes and dislikes…. Because you will be wasting your time; not to mention my own time. Other than that please feel free to make yourself known.
Coffee and conversation , Dining out , Movies/Videos , Music and concerts , Nightclubs/Dancing , Shopping/Antiques , Travel/Sightseeing , Wine tasting
Aerobics, Cycling, Dancing, Running, Walking / Hiking, Weights / Machines
I exercise 5 or more times per week.
I like to work hard and play harder. I like going out to movies, dinner, dancing.... anywhere as long as I enjoy the company of good people and environment.
Dancin, movies, going out... amd more
Fifty Shades of Gray
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'5" (165cms)
|6'0" (182cms) to 6'11" (210cms)
|Body type:
|Athletic and toned
|Slender, About average, Athletic and toned
|No preference
|Black, Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way
|Social Drinker
|Social Drinker
|I'll tell you later
|No preference
|I'll tell you later
|$75,001 to $100,000
|Never Married
|No preference
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|Bachelors degree, Graduate degree, PhD / Post Doctoral


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He Speaks So Well
Hopefully Mayor Nagin won't be teaching English to the chirrun on Nawlins' (more from that CNN story linked above):
"You can't have New Orleans no other way."
"I don't care what people are saying Uptown or wherever they are. This city will be chocolate at the end of the day," Nagin said in a Martin Luther King Jr. Day speech. "This city will be a majority African-American city. It's the way God wants it to be."...
"How do you make chocolate? You take dark chocolate, you mix it with white milk, and it becomes a delicious drink. That is the chocolate I am talking about," he said.
"New Orleans was a chocolate city before Katrina. It is going to be a chocolate city after. How is that divisive? It is white and black working together, coming together and making something special."
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Minister wants Furiani disaster marked with no games on May 5
France's Sports Minister Thierry Braillard has proposed that no football games should be played on May 5 in memory of those who died at the Furiani disaster 23 years ago.
Eighteen people were killed and more than 2000 were injured when a temporary stand at Bastia's Stade Furiani collapsed prior to the 1992 Coupe de France semifinal with Marseille.
Bastia supporters' groups have been campaigning for years to have the date of the tragedy -- May 5 -- marked by having no matches staged on it.


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Muppet Goose
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Muppet GooseMuppet Goose (1986) Season 3 Episode 313- Jim Henson's Muppet Babies Cartoon Episode Guide by Dave Koch
This page has been viewed 7 times this month, and 330 times total.
>Unknown Tag: 'short_stud_crew'
- Marvel Productions, Ltd.
- Animated Characters: Kermit, Piggy, Fozzie, Gonzo, Rowlf, Scooter, Skeeter, Animal, Nanny, Bunsen, Beaker, Robin, Yoda.
- First Aired in 1986.
- Episode Number: 313
- Running Time: 60 minutes.
- Season: 3
- Color
Cartoon Production Information:
Expanded to a full hour with the addition of The Muppet Monsters for all of two episodes. For these two episodes, the whole show was retitled Muppets: Babies and Monsters. The remainder of the year filled the second half-hour with repeats of the first season's episodes.
Developed For Television By Jeffrey Scott.
Song: Make a Nursery Rhyme.
Developed For Television By Jeffrey Scott.
Song: Make a Nursery Rhyme.
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28 year old man | Bedford Park, IL, USA | Seeking women 24-28 within 25 miles
Living proof that chivalry is not dead.
Hi! I'm Matt. I'm an average guy with a huge sense of (largely sarcastic) humor. You'd be hard pressed to say anything that would offend me and I take a joke better than anybody, guaranteed! I have a lot of interests and a lot of dreams. I am genuine and kind. I was raised with a lot of moral and ethical values and feel that that has made me a good person and I pride myself on that. Kind of ironic for a person who curses like a sailor (which I also find attractive in women, by the way) and tells a lot of dirty jokes, though... - I am very old-school; in many ways a traditionalist. I believe in chivalry and treating women with kindness and courtesy. I am non-superficial and non-judgmental and so I look for the same. Nothing is more unattractive to me that someone who is demanding. I consider myself a hopeless romantic; no problems with PDA here! I like a woman who is a woman in the traditional sense; feminine, romantic, always laughing and smiling, etc. I'll even call you ma'am if you like, even though most don't like it. I'm just throwing that out there! - Even though I've been through a lot, I tend to bounce back from things quickly; I'm a very upbeat, positive person who's always looking at the glass as half-full. If I had a more professional background I could probably be a motivational speaker, lol. Best of all I have no self-destructive coping mechanisms. I don't drink, smoke, do drugs or anything like that; I find constructive, harmless ways to release stress. - College was on hold but is now being resumed; had a lot of things to take care of, mainly parents being sick and many deaths in the family, etc. Just had a lot of bad luck. Currently looking looking to study film which is my very biggest passion in life. I'm currently working on a couple of screenplays. Luckily, I'm starting to learn what I need to get into the field. - As far as music, I love just about everything. I'll listen to anything from Oldies to Tom Petty (I'm a HUGE Petty fan) to Metal. All depends on my mood and what I'm inspired by (I am a BIG music person; it is truly my drug). However, I physically cannot handle listening to the Macarena song and I don't care what the Fox says, (humorous indicator that I don't mind if you like the song)! - I consider myself to be very non-judgmental. Everyone has flaws, you just have to see through them, and often a person's flaws makes them a more interesting person. In the end the little things end up being the best things about someone's personality. - I'm in some weird position between social and introverted. I absolutely love being with my family and I have some very good friends and am way too outgoing and silly to really be classified as an introvert but I tend to enjoy a night in quite often. Random quirky facts about me: - I'm a big storyteller and I also LOVE hearing stories/anecdotes. - I sometimes yell random gibberish when I yawn. - I tend to flawlessly use impressive words from my vocabulary and then blank on basic/common ones. - I am utterly amazing at looking like I'm a good bowler when I am not. - I have never been stung by any kind of bug or broken a bone (yet). - George Costanza is my mentor. - Be warned that I'm a geek (and I love a woman who is a geek as well!). - I might be the only person on earth who isn't much into Mexican food (although a taco here and there is fine). - I like U2, Nickelback and Creed. Yeah, I said it. Go ahead, JUDGE me! - If you couldn't tell by now, I love sarcasm! As far as my match, I'm looking for basically the same but above all else you like to smile and have fun. Class is more attractive to me than anything; if you like to wear long skirts, chances are you're the type of woman I'm looking for, lol. But ultimately If we click that's all that matters. So that's at least an in-depth start. Sorry if it was a bit much. Do you want to know more (Yeah, would you believe there's MORE still?!)? Message me and find out! :)
Camping , Coffee and conversation , Dining out , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Performing arts , Playing cards , Playing sports , Political interests , Video games , Watching sports
Baseball, Basketball, Billiards / Pool, Bowling, Cycling, Dancing, Football, Martial arts, Swimming, Walking / Hiking, Weights / Machines
I exercise 1-2 times per week.
I like Birds, Cats, Dogs
Middle of the Road
Any place that is nice. I don't drink much at all, so I don't spend much time in bars. I like going anywhere there is clean, safe fun (but I do have a bit of a wild side as well).
Strawberries, Jerky and certain kinds of seafood are my favorite foods, and others? Too many to mention. Favorite books? Anything by Stephen King. TV shows? Mainly Law and Order SVU, Family Guy, The Office.
Movies, video games, poker, sports, martial arts, some nerdy hobbies, lol. Movies: all genres, mostly profound, pure, well-made movies that are bizarre and/or very deep and meaningful like Donnie Darko, Dark City, etc. Music: Rock. From old to new.
The Shining. I'm a huge Stephen King fan.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'4" (162cms)
|4'8" (142cms) to 5'5" (165cms)
|Body type:
|Slender, About average, Curvy, Athletic and toned, A few extra pounds, Stocky
|No preference
|Light brown
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way, Occasionally, Yes, but trying to quit
|Never, Social Drinker
|Retail / Food services
|No preference
Computer Networking and Software.
|I'll tell you later
|No preference
|Never Married
|Never Married
|Have kids:
|No preference
|Wants kids:
|Definitely, Someday, Not sure
|White / Caucasian
|Asian, Latino / Hispanic, Middle Eastern, Native American, White / Caucasian
A little of Irish, Native American, and Polish blood in me.
|No preference
Agnostic, but open-minded and not judgmental at all.
|No preference
|Associates degree
|No preference
Starting anew to study film sometime this year, hopefully.


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33 year old man | Spring Park, MN, USA | Seeking women 25-32 within 15 miles
Looking for someone who likes to laugh and have fun in life!!!
Hello, I'm a very out going guy, who enjoys being with family and friends. Originally from Illinois, but moved to MN a little over 4 years ago. Always looking to find new things to do and places to go when the opportunity strikes. I am sarcastic, fun and passionate. Love to laugh. I have a passion for the outdoors and anything that involves me being on the water. Love working out and keeping myself actively healthy. I work hard and have goals set in place. Looking to find someone who is outgoing, fun, energetic and enjoys traveling. Close to their family . Someone who is genuine and enjoys the good things in life. If you're interested in learning more, shoot me an email or send a wink and we can go from there!!
Camping , Coffee and conversation , Business networking , Cooking , Dining out , Fishing/Hunting , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Playing cards , Playing sports , Religion/Spiritual , Travel/Sightseeing , Watching sports , Wine tasting
Baseball, Billiards / Pool, Football, Other types of exercise, Running, Skiing, Swimming, Walking / Hiking, Weights / Machines, Yoga
I exercise 5 or more times per week.
I have Cats, Fish
I like Dogs
Middle of the Road
Going to my brothers lake property in Battle Lake, Being on the water, Going out on a casual night with family or friends.
University of Wisconsin–Parkside, Kenosha, WI
I like to listen to all types of music, . I like all types of food but if I were to choose it would be sea food!
Anything from hanging out with family and friends to going camping, traveling, boating, jet skiing, hiking, softball, watching sports, skiing, snowmobiling.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'10" (177cms)
|5'0" (152cms) to 5'10" (177cms)
|Body type:
|About average
|Slender, About average, Athletic and toned
|No preference
|Dark brown
|No preference
|No Way
|No Way, Yes, but trying to quit
|Social Drinker
|Social Drinker
|Sales / Marketing
|No preference
Key Account Manager at a Software Company
|$75,001 to $100,000
|No preference
|Never Married
|Never Married
|Have kids:
|Yes, and they sometimes live at home, No, Yes, and they live at home
|Wants kids:
|White / Caucasian
|White / Caucasian
I am German, Norwegian, Check Slovakian
|Christian / Catholic
|Christian / Catholic
|Bachelors degree
|High school, Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral
I have a Bachelors Degree in Arts with concentration in Computer Illustration and Graphic Design from the University of Wisconsin-Parkside.


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Originally written on Fox Sports | Last updated 3/21/13
DENVER - JANUARY 16: Head coach Joe Sacco leads the Colorado Avalanche against the New Jersey Devils during NHL action at the Pepsi Center on January 16, 2010 in Denver, Colorado. The Avalanche defeated the Devils 3-1. (Photo by Doug Pensinger/Getty Images)
Joe Sacco's decision to shake up his lineup paid immediate dividends for the Colorado Avalanche coach. Sacco inserted little-used Mark Olver into the lineup, and the forward had a goal and an assist to help spark Colorado's rally in the third period that beat the Dallas Stars, 4-3, on Wednesday night. Chuck Kobasew also had two points - including the game-winning goal - and Ryan O'Reilly had a goal and an assist for the Avalanche, who snapped a four-game skid. It was a banner return to action for Olver, who had been a healthy scratch for seven games. He used the opportunity to state his case for more playing time. ''It hasn't been very good. I've been out of the lineup for a while and it was good to make a contribution,'' he said. ''I made mine tonight when it counted.'' Olver was almost the hero when Colorado came all the way back from a two-goal deficit. The Avalanche got the winner when Matt Hunwick's shot from the boards hit Dallas defenseman Stephane Robidas in the back of...
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text: GamesBeat Check out this printable Mass Effect 3 voice command "cheat sheet" February 22, 2012 3:54 PM Sebastian Haley 0 Gaming is in its golden age, and big and small players alike are maneuvering like kings and queens in A Game of Thrones. Register now for our GamesBeat 2015 event, Oct. 12-Oct.13, where we'll explore strategies in the new world of gaming. Microsoft suspects there may be a few gamers getting ready to save the universe from the Reapers come March 6. To help fight off the invasion and ensure the Kinect stays relevant, at least for a couple more months, a voice command cheat sheet for Mass Effect 3 has been created. I can't really imagine my FemShep barking orders in my voice (nor do I want to), but I will admit the potential for the Kinect functionality to greatly improve in-game tactics; no more stopping the action every few seconds to select abilities or tell Garrus to take cover. When you're done picking out typos (what is Cyro Ammo?!), let's all just hope that the voice commands work better than it did in Lifeline.


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financial analytics
Financial analytics is the creation of ad hoc analysis to answer specific business questions and forecast possible future financial scenarios.
Financial Analytics
Financial analytics is the creation of ad hoc analysis to answer specific business questions and forecast possible future financial scenarios. Financial analysis software can speed up the creation of reports and present the data in an executive dashboard, a graphical presentation that is easier to read and interpret than a series of spreadsheets with pivot tables.
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Popular financial analysis software programs include:
Oracle Financial Analytics - modular component of Oracle's integr ated family of business intelligence (BI) software applications. Enables insight into the general ledger, provides visibility into performance against budget and the way staffing costs and employee or supplier performance affects revenue and customer satisfaction.
SAP ERP Financial Analytics - help organizations define financial goals, develop business plans and monitor costs and revenue during execution.
SAS Business Analytics - provides an integrated environment for data mining, text mining, simulation and predictive modeling -- a mathematical model that predicts future outcomes – as well as descriptive modeling, a mathematical model that describes historical events and the relationships that created them.
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35 year old woman | Salt Lake City, UT, USA | Seeking men 27-37 in United States
Slightly accident-prone romantic seeks individual who will laugh, kiss it better, and offer the occasional band-aid
I'm looking for someone who also loves to laugh and take care of others, preferably while listening to some good music - maybe the Clash or Social Distortion if it's been a rough day - otherwise I'm pretty open so long as we can always start a road trip with "Where the Streets Have No Name" Someone who will readily hop in the car just to go see something historic or beautiful. Art and Education are important to me - Life-long learning and compassion are philosophies I try to live My ultimate career ambition is to be a free-lance choreographer and writer. I also love teaching. Family is at the center of my life - I believe laughter and faith to be the values that sustain us and I'm grateful for the ties I have. I adore my nieces and nephew. In terms of relationships... I don't really have a type but chemistry is extremely important - Dishonesty is the only real deal-breaker for me - massages, a definite plus. I'm independent, but I'd love to find someone I can lean on - protect me but give me space when I need it and I'll do the same for you. I live both extremes of working hard or veggin' out - I need a guy who can wake up early or sleep in and cuddle. A full moon, red sneakers, or a snide one-liner from Groucho, puts a smile on my face, and I think my italian cooking might put a smile on yours. I would rather climb over a fence than go out of my way to get somewhere, and if you unwisely choose to engage me in a water-fight - you will lose - just sayin'...
Camping , Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Travel/Sightseeing , Volunteering
Dancing, Running, Walking / Hiking
I exercise 5 or more times per week.
I like Dogs
Middle of the Road
Florence, London, Oia - Santorini, Plaza dell Rotunda - Rome, any beach, most any city, Olympic Peninsula, Mountains, being on the road. My balcony :)
University of Utah, Salt Lake City, UT
Punk/indie/classic rock, tangos, and saucy blues. Movies more than TV but Moone Boy, Mash, Freaks and Geeks. I crave Italian infused with pesto/ olive oil, and Diet Coke = my vice. Driving south is good for the soul. Late night city walks.
Enjoy movies, music, reading, hiking, eating, going to plays and concerts, ball games, learning to play electric guitar, hitting the road
Dorian Gray, Catch 22, A Visit from the Goon Squad and How We are Hungry. Favorites = Honesty, Goodnight Mr. Tom, A Midsummer Night's Dream, and A Brief History of the Dead.
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text:
A method of treating a biological tissue including crosslinking with glutaraldehyde; immersing the biological tissue in a first solution containing glutaraldehyde and heat in the first solution to a temperature of about 50° C. for a first period of time; immersing the biological tissue in a second solution containing a mixture of a crosslinking agent, a denaturing agent and a surfactant; and immersing the biological tissue in a sterilizing solution containing glutaraldehyde and heating the sterilizing solution to a temperature of 37.5±2.5° C. for a sterilizing period of time. The method may include a terminal sterilization step in a method for fixation of biological tissues, and bioprosthetic devices may be prepared by such fixation method. The fixation method may include the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to the terminal sterilization method.
1. A method of treating biological tissue for making a bioprosthesis which contains connective tissue protein to reduce the potential for post-implantation calcification and thrombogenicity, comprising:
a) contacting the biological tissue with a first solution containing a surfactant and a denaturing agent selected from the group consisting of formaldehyde, ethanol, isopropanol, acetone, methyl ethyl ketone, a lower alkyl ether, a glycol, a chaotropic agent, and a highly concentrated salt solution;
b) fixing the tissue of step (a) by immersing said tissue in a buffered fixative solution containing a crosslinking agent for 0.5 hours to 14 days at 4-37° C.;
c) contacting the fixed tissue of step (b) with more of said first solution,
d) heating the tissue of step (c) in a buffered solution containing a crosslinking agent to about 50° C.;
e) assembling a bioprosthesis by attaching any non-biological components of the prosthesis to the tissue of step (d);
f) contacting the assembled bioprosthesis of step (e) with more of said first solution, and
g) sterilizing the bioprosthesis of step (f) by immersing the bioprosthesis in a sterilizing solution containing glutaraldehyde, and heating said sterilizing solution to 37.5±2.5° C. for a sterilizing period of time.
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This application is a continuation of U.S. patent application Ser. No. 10/345,120, filed Jan. 14, 2003 now U.S. Pat. No. 7,214,344, which is continuation of U.S. patent application Ser. No. 09/828,650, filed Apr. 6, 2001, now U.S. Pat. No. 6,547,827 which is a continuation of U.S. patent application Ser. No. 09/157,546, filed Sep. 21, 1998, now U.S. Pat. No. 6,214,054, the disclosures of which are incorporated fully herein by reference.
The invention pertains generally to medical method/devices and more particularly to a method for fixing (e.g., tanning or crosslinking) and sterilizing biological tissue to I) decrease the fixed tissue's propensity for post-implantation calcification and ii) decrease the thrombogenicity of the fixed tissue.
Various types of implantable medical devices may be formed wholly or partially of biological tissue that has been chemically "fixed" or preserved. The technique used for chemical fixation of biological tissues typically requires exposure of the biological tissue to one or more chemical agents that are capable of forming cross-linkages between connective tissue protein molecules present in the tissue.
Examples of fixed biological tissues that have been used to form implantable bioprostheses include cardiac valves, blood vessels, skin, dura mater, pericardium, ligaments and tendons. These biological tissues typically contain connective tissue proteins (i.e., collagen and elastin) which act as the supportive framework of the tissue. The pliability or rigidity of each biological tissue is largely determined by the relative amounts of collagen and elastin present within the tissue and/or by the physical structure and confirmation of its connective tissue frame work.
Each Collagen molecule is made up of three (3) polypeptide chains intertwined in a coiled helical confirmation. The Chemical fixatives (i.e., tanning agents) which are used to preserve biological tissues generally form chemical cross-linkages between the polypeptide chains within a given collagen molecule (i.e., intramolecular crosslinkages), or between adjacent collagen molecules (i.e., intermolecular crosslinkages).
Examples of chemical fixative agents which have been utilized to cross-link collagenous biological tissues include; aldehydes (e.g., formaldehyde, glutaraldehyde, dialdehyde starch, para formaldehyde, glyceroaldehyde, glyoxal acetaldehyde, acrolein), diisocyanates (e.g., hexamethylene diisocyanate), carbodiimides, photooxidation, and certain polyepoxy compounds (e.g., Denacol-810, -512, or related compounds). Of the various chemical fixatives available, glutaraldehyde is the most widely used. Glutaraldehyde is used as the fixative for many commercially available bioprosthetic products, such as porcine bioprosthetic heart valves (e.g., Carpentier-Edwards® Stented Porcine Bioprosthesis), bovine pericardial heart valve prostheses (e.g., Carpentier-Edwards® Pericardial Bioprosthesis), and stentless porcine aortic prostheses (e.g., Edwards® PRIMA Stentless Aortic Bioprosthesis), all available from Edwards Lifesciences of Irvine, Calif.
One problem which has been associated with the implantation of bioprosthetic materials is that the connective tissue proteins (i.e., collagen and elastin) within these materials can become calcified following implantation within the body. Such calcification can result in undesirable stiffening or degradation of the bioprosthesis. Two (2) types of calcification—intrinsic and extrinsic—are known to occur in fixed collagenous bioprostheses, although the exact mechanism(s) by which such calcification occurs is unknown. Intrinsic calcification is characterized by the precipitation of calcium and phosphate ions within the fixed bioprosthetic tissue, including the collagen matrix and remnant cells. Extrinsic calcification is characterized by the precipitation of calcium and phosphate ions within the thrombus, including adherent cells (e.g., platelets) to the bioprosthesis and the development of calcium phosphate-containing surface plaques on the bioprosthesis.
The factors that affect the rate at which fixed tissue bioprostheses undergo calcification have not been fully elucidated. However, factors that are thought to influence the rate of calcification include:
The factors that are thought to affect the propensity for platelets to adhere to a fixed bioprosthetic tissue include:
Various techniques have heretofore been proposed for mitigating the in situ calcification of glutaraldehyde-fixed bioprostheses. Included among these calcification mitigating techniques are the methods described in U.S. Pat. No. 4,885,005 (Nashef et al.) entitled Surfactant Treatment of Implantable Biological Tissue To Inhibit Calcification; U.S. Pat. No. 4,648,881 (Carpentier et al.) entitled Implantable Biological Tissue and Process For Preparation Thereof; U.S. Pat. No. 4,976,733 (Girardot) entitled Prevention of Prosthesis Calcification; U.S. Pat. No. 4,120,649 (Schechter) entitled Transplants; U.S. Pat. No. 5,002,2566 (Carpentier) entitled Calcification Mitigation of Bioprosthetic Implants; EP 103947A2 (Pollock et al.) entitled Method For Inhibiting Mineralization of Natural Tissue During Implantation and WO84/01879 (Nashef et al.) entitled Surfactant Treatment of Implantable Biological Tissue to Inhibit Calcification; and, in Yi, D., Liu, W., Yang, J., Wang, B., Dong, G., and Tan, H.; Study of Calcification Mechanism and Anti-calcification On Cardiac Bioprostheses Pgs. 17-22, Proceedings of Chinese Tissue Valve Conference, Beijing, China, June 1995.
There presently remains a need in the art for the development of new calcification-mitigating methods for fixing (i.e., tanning and crosslinking) and sterilizing biological tissues to provide bioprosthetic devices which are a) less likely to become calcified and b) less thrombogenic, following implantation within a patient's body.
Broadly stated, the present invention provides a method for chemical fixation and sterilization of biological tissue, comprising the steps of:
Further in accordance with the invention, there are provided various types of bioprosthetic articles that are wholly or partially formed of tissue that has been prepared by the above-summarized fixation/sterilization method of the present invention. Examples of specific biological tissues which may be utilized to prepare bioprosthetic articles in accordance with this invention include, but are not necessarily limited to: heart valves; venous valves; blood vessels; ureter; tendon; dura mater; skin; pericardium; cartilage (e.g., meniscus); ligament; bone, intestine (e.g., intestinal wall); and periostium.
Further aspects and objects of the present invention will become apparent to those skilled in the relevant art, upon reading and understanding the detailed description of presently preferred embodiments set forth herebelow.
Additional embodiments and aspects of the invention may become apparent to those of skill in the art upon reading and understanding of the detailed description and specific examples set forth herebelow.
As shown in
Step 1: Harvest/Prepare Biological Tissue
The desired biological tissue is harvested (i.e., surgically removed or cut away from its host animal). Thereafter, it is typically, trimmed or cut to size and washed with sterile water, balanced salt solution, saline or other suitable washing solution.
Step 2: Fixation of Biological Tissue
The biological tissue is then contacted with a crosslinking agent, such as an aldehyde (e.g., formaldehyde, glutaraldehyde, dialdehyde starch), polyglycidyl either (e.g., Denacol 810), diisocyanates, photooxidation, or carbodiimide(s)) to crosslink the connective tissue proteins present within the tissue. Due to the long standing use and experience with glutaraldehyde, a presently preferred fixative for use in this step is a solution of 0.2-2.0% by weight glutaraldehyde. For example, the biological tissue may be immersed in a solution of 0.625% by weight glutaraldehyde buffered to a pH of approximately 7.4 by a suitable buffer such as a phosphate buffer, for 0.5 hours to 14 days at 4-37 degrees C.
Step 3: Treatment with Denaturant/Surfactant/Crosslinking Agent (DSC Treatment:
The tissue is preferably immersed in the DSC solution for 2 to 24 hours and typically about 9 hours. During this immersion period, the DSC solution is maintained at a temperature of 4-50 degrees C., and typically about 20-37 degrees C.
Those skilled in the art will appreciate that various alternative chemical compounds or solutions may be substituted for each component of the DSC solution, as follows:
Potential Alternative Denaturing Agents:
Alcohols/Solvents: e.g., ethanol, isopropyl alcohol, acetone, ethers of small alkyl size (methyl, ethyl, propyl, isopropyl)
Acidified Ethers: e.g., sulfuric acid/ether mixture
Ketones: e.g., methyl ethyl ketone (MEK)
Chlorofluorocarbon Solvents: e.g., Genesolve™ (Allied Signal, Inc., Morristown, N.J.)
Glycols: glycerol ethylene glycol, polyethylene glycols of varying molecular weight
Chaotropic Agents: e.g. urea, guanidine hydrochloride, guanidine thiocyanate potassium iodide
High Concentration Salt Solutions: e.g., lithium chloride, sodium chloride, cesium chloride.
Anionic Surfactants: e.g., esters of lauric acid, including but not limited to sodium laurel sulfate (also called sodium dodecyl sulfate)
Alkyl sulfonic acid salts: e.g., 1-decanesulfonic acid sodium salt
Non-ionic compounds: e.g., compounds based on the polyoxyethylene ether structures (including Triton X-100, 114, 405, N-101 available commercially from Sigma Chemical, St. Louis, Mo.), and related structures; Pluronic and Tetronic surfactants (available commercially from BASF Chemicals, Mount Olive, N.J.)
Alkylated Phenoxypolyethoxy Alcohols: e.g., NP40, Nonidet P40, Igepal, CA630, hydrolyzed/functionalized animal and plant compounds including, Tween 80, Tween 20, octyl-derivatives, octyl b-glucoside, octyl b-thioglucopyranoside, deoxycholate and derivatives thereof, zwitterionic compounds, 3-([cholamidopropyl]-dimethyl ammonio)-1-propanesulfonate (CHAPS), 3-([cholamidopropyl]-dimethyl ammonio)-2-hydroxy-1-propanesulfonate (CHAPSO) available from Pierce Biotec Company, Rockford, Ill.
Potential Alternative Crosslinking Agents:
Aldehydes: formaldehyde, glutaraldehyde, paraformaldehyde, glyceraldehyde, glyoxal acetaldehyde or acrolein, dialdehyde starch
Epoxides: e.g., any of the various Denacols and their individual reactive species, including mono, di, tri, and multi-functionalized epoxides
Step 4. Assembly/Fabrication of Prosthesis
After completion of Steps 1-3, and irrespective of the order in which Steps 2 and 3 were performed, the tissue is rinsed with a suitable rinsing solution such as isotonic saline or 0.625% glutaraldehyde. Thereafter, the tissue may be transported into a clean room or aseptic environment, and may be further trimmed or shaped (if necessary) and attached to or assembled with any non-biological components (e.g., stents, frames, suture rings, conduits, segments of polyester mesh to prevent suture tear-through, etc.). To form the desired implantable bioprosthetic device. Examples of such assembled bioprosthetic devices include porcine bioprosthetic heart valves (e.g., Carpentier-Edwards® Stented Porcine Bioprosthesis), bovine pericardial heart valve prostheses (e.g., Carpentier-Edwards® Pericardial Bioprosthesis), stentless porcine aortic prostheses (e.g., Edwards® PRIMA Stentless Aortic Bioprosthesis), all available from Edwards Lifesciences of Irvine, Calif., and bio-mechanical ventricular assist devices (e.g., the Novacor® LVAS; World Heart Inc., Oakland, Calif.).
Step 5: Treatment with Denaturant/Surfactant/Crosslinking Agent (DSC Treatment) (Optional)
Optionally, the DSC treatment described in Step 3 above may be carried out at this point in the procedure instead of as the third (3rd) step of the procedure. Or, if such DSC treatment has already been performed as the third (3rd) step of the procedure, it may be repeated at this point in the procedure (e.g., as the fifth (5th) step of the procedure).
Step 6: Terminal Sterilization
The bioprosthesis is immersed in or contacted with a terminal sterilant and heated for a period of time sufficient to ensure sterility of the bioprosthesis until the time of implantation. This terminal sterilization procedure is preferably carried out in the sealed container or package in which the bioprosthesis will be shipped and stored until the time of implantation.
A preferred terminal sterilant is 0.2-2.0% by weight glutaraldehyde, and most preferably about 0.25% by weight glutaraldehyde. Although DSC solution or compounds of the DSC solution can also be used. The preferred terminal sterilization time and temperature is 1-6 days at 37° C. or 1-2 days at 50° C.
Preparation of a Stented Pericardial Valve Bioprosthesis
The following is an example of the manner in which a stented pericardial bioprosthetic heart valve may be manufactured in accordance with the method of the present invention.
STEP 1: A bovine pericardial sac is obtained from a slaughterhouse, placed on ice, and transported to the location at which the bioprosthesis will be manufactured. Thereafter, the tissue is defatted and trimmed.
STEP 2: The tissue is washed with sterile isotonic saline solution and is thereafter immersed in a solution of 0.625% by weight glutaraldehyde buffered to a pH of approximately 7.4 by a suitable buffer such as a phosphate buffer, for approximately thirty minutes at room temperature. This results in crosslinking of the collagen present within the tissue.
STEP 3: The tissue is then removed from the fixative solution used in Step 2 and rinsed thoroughly with an aqueous solution of 0.625% (by weight) glutaraldehyde. Sometime thereafter, the DSC Treatment of Step 3 is carried out by immersing the tissue in DSC solution for 2 hours at ambient temperature. The DSC solution has the following formula:
STEP 4: After completion of the DSC Treatment of Step 3, the tissue is removed from the DSC solution and leaflets are formed. Thereafter, the leaflets are mounted upon and sutured to a stent. Also, a needle-penetrable suture ring is attached about the inflow end of the valve to facilitate suturing of the bioprosthesis to the native tissue of the host patient. This completes the assembly and fabrication of the bioprosthetic heart valve.
STEP 5: Subject the finished valve after inspection to DSC treatment again for 9 hours at 37° C.
STEP 6: After the bioprosthesis is removed from the DSC solution it is transferred to a container which has been pre-filled with 0.25% glutaraldehyde aqueous solution buffered to a pH of 7.4 with sodium hydroxide such that the bioprosthetic valve is fully immersed in the buffered glutaraldehyde solution. Thereafter, the container is sealed and placed in an oven where it is heated to a terminal sterilization temperature of 37.5+/−2.5 degrees C. for 25-27 hours. Thereafter, the container is cooled to room temperature and shipped to the hospital or other location(s) where it is stored until the time of implantation of the bioprosthetic valve.
Studies were performed to objectively assess the benefits of the above-described process in mitigating calcification and improving hemocompatibility. First, the new process was compared with a process as shown in
In the first comparison study, control tissues were generated by traditional glutaraldehyde fixation in conjunction with a terminal sterilization step as described above. In these tests, circular pieces of tissue prepared by the new method and by the control method were surgically placed in either the subcutaneous space in rats and rabbits, or in a pocket created in the paravertebral muscle in the rabbit. After thirty days implantation the tissues were excised from the host tissue, rinsed, and calcium content is determined by atomic absorption spectroscopy. The study results are as follows:
As is apparent, tissue produced according to the new process demonstrate reduced calcification in rat and rabbit implantation assays, and demonstrate the superiority of the new tissue preparation method compared to the control method.
The second study shows that tissues prepared according to the new method also demonstrate reduced adhesion of blood cells compared to a traditional treatment methods. The control method for the second study is seen in
The invention has been described hereabove with reference to certain presently preferred embodiments or examples only, and no effort has been made to exhaustively describe all possible embodiments or examples of the invention. Those skilled in the art will recognize that various modifications, additions and changes may be made to the particular embodiments and examples described hereabove without departing from the intended spirit and scope of the invention. Accordingly, it is intended that all such modifications, additions and changes be included within the scope of the following claims.
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love u rashami plzz quit ut fr ur fans...
good evening dear .. looking very beautiful in green saree on 31.5.13 epi # utaran
rashami love you sooo much...u r d most beautiful girl n most talented too...
luv u rashami...u rockkzzz...
love u rashami...ur d best actress of uttran..totally wasted...plz join a new show
Good nite dear
plz come in new show with nandish
luv u rashami desai sandhu...u r bst...plzz quit ut we wnt u in new shw...
Love U rashami
Love U rashami
U R the best ! Love U a lot
love u rashami...wnt u to quit ut...cnt tolerate cv's torture anymre...
Yoy just rocked in ITA awards..you are simply superb n multi talented...love rashami
Edited on:27 May 2013 at 5:27am
love u rashami desai sandhu njyng wtchng u hstng ITA...ur ntry ws awsum on d sng tv tv ...u r rockkng agn nd luvd nandish whn he ws shwn blushng at momnts...
Love U rashami !
Good night
Rashmi...U R-
small screenshot utility
love u rashmi. ur looking gr8 with rpr. saw ur pics on rasya AT.
keep rocking.
and try to quit if possible and come in a new show with nandish.
luve u rashami...wanna bck in new shw...
Love U rashami ! Plz come in new show with Nandish
Edited on:24 May 2013 at 11:44am
Rashmi Desai sandhu, you're the cutest girl in uttaran. You're loyal to uttaran. You're awesome in your role as tapasya
Love u Rashami desai sandhu...plz quit ut asap..it doesnt deserve u..
rashami ur the best actress of uttran...rare combination of superb talent n beauty...proud to be your fan
Watched uttaran after a long time you just rocked love you lots
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Second Limited Production Order for MIDS JTRS Terminals
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Deliveries continue on first JTRS program to achieve production status
Carlsbad, Calif. – ViaSat Inc. (Nasdaq:VSAT) has been awarded a Limited Production order valued at $6.8 million for Multifunctional Information Distribution System Joint Tactical Radio System (MIDS JTRS) terminals for the U.S. government. The award resulted from a competitive procurement through the Space and Naval Warfare Systems Command (SPAWAR). The order was awarded under the MIDS Indefinite Delivery/Indefinite Quantity contract initially executed in March 2010. The MIDS JTRS terminals are for F/A-18E/F, RC-135 Rivet Joint, and EC-130H Compass Call aircraft.
MIDS JTRS is a joint development of ViaSat and Data Link Solutions and provides a migration path from the MIDS-Low Volume Terminal (LVT) to a certified, reprogrammable, software-defined radio architecture for tactical data links. The terminal has completed contractor and government qualification testing, and received the following certifications:
- Software Communications Architecture (SCA) compliance
- Electromagnetic Compatibility (EMC) certification
- Joint Interoperability Test Command (JITC) interoperability
- NSA security certification
ViaSat expects to enter full production and fielding in 2011. The MIDS JTRS adds three programmable channels to the legacy Link-16 and TACAN capabilities of the MIDS-LVT. The three new channels are designed to host future advanced airborne networking waveforms. MIDS JTRS is "plug-and-play" backward compatible with MIDS-LVT so it can easily replace the MIDS-LVT, but remain interoperable.
Safe Harbor Statement
This press release contains forward-looking statements that are subject to the safe harbors created under the Securities Act of 1933 and the Securities Exchange Act of 1934. Forward-looking statements include statements that refer to the expected dates for full production and fielding. ViaSat wishes to caution you that there are some factors that could cause actual results to differ materially, including but not limited to: contractual problems, product defects, manufacturing issues or delays, regulatory issues, technologies not being developed according to anticipated schedules, or that do not perform according to expectations; and increased competition and other factors affecting the defense industry generally. In addition, please refer to the risk factors contained in ViaSat's SEC filings available at www.sec.gov, including ViaSat's most recent Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. Readers are cautioned not to place undue reliance on any forward-looking statements, which speak only as of the date on which they are made. ViaSat undertakes no obligation to update or revise any forward-looking statements for any reason.


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Interstate 95
Elderly Man Killed In I-95 Breakdown Lane By Alleged Drunk Driver
The North End is mourning the death of a 71-year-old tailor who was a fixture in the community.
Driver Killed In Crash On I-95 In Foxboro
State police say a Kia Sorento was travelling on 95 south around 5:20 a.m. when it hit a guardrail and went into the woods just before exit 6B.
I-95 Motorcycle Crash In Newton Kills Woman
A woman suffered fatal injuries Sunday night when the motorcycle she was riding as a passenger crashed on Interstate 95 in Newton, state police said.
Mom Dead, 2 Kids Hurt In Crash On Ramp Linking Mass Pike, I-95 In Weston
One person was killed and two others were hurt in a crash on a ramp from the Massachusetts Turnpike to Interstate 95 Saturday.
Bus Driver May Have Had Medical Incident Before I-95 Crash
The driver of a tour bus that ran off a highway north of Boston Tuesday night may have had a medical episode just before the crash.
Dump Truck Crashes Into Overpass On Route 128 In Canton
A dump truck crash brought the start of rush hour to a crawl on Route 128 in Canton early Thursday morning.
Sheriff's Deputy Killed In Motorcycle Crash On I-95 In Sharon
A sheriff's deputy was killed in a motorcycle crash on Interstate 95 during rush hour Tuesday morning.
Tour Bus, 2 Cars Crash On I-95 In Canton
The northbound side of Interstate 95 was shut down briefly early Thursday afternoon after a tour bus and two cars crashed.
Crash Shuts Down Route 128 In Westwood
Both sides of Route 128 were shut down late Tuesday morning after an accident in Westwood.
1 Dead In Crash On I-95 In Attleboro
A person was killed in a crash on Interstate 95 in Attleboro early Wednesday morning.


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The First Lady led the Presidential Delegation to the Milan Expo 2015, showcasing our steadfast commitment to a healthier nation.
The President challenged the First Lady to #GimmeFive FLOTUS-style. Check out her response!
Fifty-five talented kid chefs are headed to the White House on July 10 for this year's Kids' "State Dinner."
The First Lady was joined by students from Let's Move! programs across the country to prepare a delicious meal with veggies straight from White House Kitchen Garden.
Check out our new interactive map and find Let's Move! programs in your community!
On Tuesday, the First Lady hosted the first-ever White House Campout on the South Lawn, one of America's most iconic National Parks. Fifty Girl Scouts were invited to participate in the campout, co-sponsored by the U.S. Department of the Interior, that celebrated the centennial of the National Park Service and promoted getting kids and families moving while taking advantage of America's great outdoors as part of Let's Move! Outside.
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The concept of descendents of other characters has always struck me as a weird concept. Not hat it isn't valid, but it does seem redundant. We have concepts for things like parents, but the alias field for DooC is particularly outlandish given that it covers family relations like cousins that aren't descendants. Maybe a concept like "Distant Ancestor" or something of that nature would work better.
Or at the very least, rename the existing concept so that it isn't so awkward.


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Markets :: Specialty Chemicals :: Adhesives and sealants
Caulks, Sealants Demand to Rise
11:00 AM MDT | October 20, 2008 | Chemical Week Editorial Staff
U.S. caulks and sealants demand is expected to rise 2.9%/year to more than 2 billion lbs and reach nearly $4 billion in 2012, says a recent study by The Freedonia Group (Cleveland). The study cites strengthening in end-market fundamentals including an expected improvement in aerospace, motor vehicle, and two "critical" construction markets—residential building and nonbuilding markets such as highways. Demand in the construction market is expected to increase 3%, to 1.2 billion lbs by 2012, the study...
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NESH Mind Body Soul is among several newly opened businesses in the neighborhood.
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Here are eight stories you may have missed in New York this week.
Local officials asked Boobie Trap to hide its "f--k off" neon sign due to its location near schools.
A celebrity chef-led restaurant and a bagel cafe with more than 30 flavors of cream cheese have opened.
Belgian Beer Café will launch at 220 Fifth Ave., overlooking Madison Square Park, at the end of August.
The new Max Fish features several relics from the old location, including a cigarette-shaped light.
Cedar Local, which recently opened at 25 Cedar St., specializes in classic and original cocktails.
Owners of the 13-year-old dive bar, closing on July 31, said they are looking for a new location.
The Starlite Lounge closed in 2010 after its building's landlord sold the space.
The Jolly Monk serves waffles, waffle sliders and 24 beers on tap.
Organizers said they want Prospect Heights to be viewed as a destination neighborhood.
The owners of Uncle Barry's in Park Slope will open Moot Bar in Bed-Stuy.
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