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Our Customers Have Spoken!
Don't ever drop theseThese earrings are so cute once you get them on. And therein lies the problem - getting them on. They are really TINY. They are a real struggle to get them on because they are so tiny. The first time I tried them on, I dropped the largest piece on the floor. I spent 20 minutes on my hands and knees with a flashlight looking for it. The second time, I cleared off my sink and used my great lighted magnifying mirror. Dropped the large piece again; another 20 minutes. Once they are on, they are really cute and understated, but ask yourself if the struggle to get the three pieces on without dropping a piece is worth the full price of these earrings. I think not. The aesthetic design is great; the functionality of getting them on is really bad.
Lovely and uniqueThese earrings are lovely and unique. I am seeing a lot of these "ear jacket" style earrings lately, but nowhere else has turquoise. I love them, and they seem to be pretty good quality. They are super tiny and dainty, but that is what I was expecting/wanting. I already have a similar pair that is just CZ, so I will just have to see how the turquoise color works into my wardrobe.
Beautifully uniqueI fell in love with these when I tried them on. The detail on these earrings is amazing. I love that I can wear them over and over and still get compliments about how unique they are. The only downside I would have is that they can be a little tricky getting them on, there are multiple holes which allows for different sized ear lobe which is great but sometimes hard to line up just right.
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Beautiful StudsThese earrings are gorgeous. They are a bit smaller in real life than they look on the website so you cant see the detail of the flaws in the stone unless held right up to your eyes. But they add a pop of color to every outfit and are absolutely beautiful.
Simple and ElegantGorgeous color blue that gives a pop to any outfit.
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Sweet & FeminineBeautiful earrings! Classic and feminine. Perfect size.
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Beautiful and well made!I purchased these earrings to go with the Tranquil Medallion Pendant necklace. They are very uniquely shaped, are lightweight and seemed to be well made. The stone is actually white with gray speckles. I like them as they are not overwhelming and match so many outfits!
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Shades of GreyThese look lovelier in person. The labradorite stones are grey with natural inclusions so they look real. The gold plated setting is slightly different than pictured and is well made and hallmarked in the back. They are comfortable to wear and show up even against my long dark hair. They coordinate with the Labradorite Zermatt Necklace but will stand on their own since they are neutral. Thanks to Anthro I am building a collection of jewelry with natural stones, including quartz and white topaz, and am learning about their properties.
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Different!I really like the Damselfly post earrings because they are light weight. They are very beautiful, and not too big. These earrings are eye catching, and I have already gotten compliments. The only reason why I did not give these earrings a five star is because they are suppose to be a product of France. When I got the package in the mail, and opened it up, it said "Made in China." If you're looking for something made in France, this is not it, but it is good costume jewelry.
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Need a fresh perspective on your tried-and-true outfits? Like leaves for trees and feathers for birds, earrings for women are the perfect finishing touch. There's a pair of earrings for every getup, whether they're sparkly chandeliers or gem drops, filigree hoop earrings or simple pearl posts. The world of women's earrings encompasses every textured terrain you can imagine, too-from florals to feathers, roses to rainfall, crystals to tassels-the possibilities are endless. Women's earrings are the little expressions of style that make a big, big difference!


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Senior Project and Product Manager
Philippines - Last active: 1 day ago - Tests: 17
My consulting maxim is to be known for my integrity at work and to overwhelm my clients and teammates with it. As an Offshore Project Manager for over 6 years now, I am driven by a long-term perspective extending beyond the limits of my current projects. From conception, I make sure that I'm able to identify at a deep personal level with my client's project goals. With this mindset, I possess a new level of personal drive to succeed because the goals are the right ones to pursue. During project execution, I aim to invest in making a significant effort to build trust within my team and across the full range of stakeholders through my work ethics and technical adeptness combined. And on the final phase, my criteria for a successful project will always be to ensure that the "value of the project" was delivered. This is definitely far more important than just delivering a project to its sponsors.
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Nepal - Last active: 1 day ago - Tests: 8 - Portfolio: 14
Hello Everyone, An exceptional Wordpress Master, Open Source Expert and Web 2.0 Strategist with 8 years of service excellence in IT industry. I specialize in WordPress, HTML, CSS, MySQL, PHP, jQuery, AJAX and SEO. I prefer working in WordPress Theme Development and Customization. I have developed several Custom WordPress Theme for my Clients ranging from small to large businesses in United States, Europe and Australia. At my free time, I like to contribute to WordPress Community. I have developed 6 free WordPress Themes. Catch Box, Simple Catch, Catch Everest, Catch Evolution, Catch Kathmandu and Adventurous which are at the most popular free themes in WordPress.org Theme Directory. I also volunteer as WordPress Theme Reviewer in WordPress Theme Review Team. I deeply value communication, long term commitment, deadline and innovative approach to provide "life to your projects". I work strictly with web technology standards. Thank you for taking the time to read my profile and I look forward to work with you in near Future. Best regards, Sakin
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WordPress Webdesign, Online Business Manager, Graphic Design
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Wordpress Expert - PAGE DOWN TO VIEW MY PORTFOLIO Hello Buyer! I am not the cheapest provider on oDesk, but I am a highly skilled individual with experience in many areas of internet business, back office support, wordpress, and marketing as well as over 20 years experience offline in a variety of administrative, financial and management roles. Core Competencies Online Business Management (OBM) - Congratulations! You have a successful business...but how many hours a week do you waste on mundane tasks, repetitive housekeeping and items which do not best utilize your time. You should be creating products, bringing in clients and making money, leytme do the rest! I can help you organize and automate. Save time, take a vacation this year! Wordpress Website Customization and Maintenance, Site Builds, Support & Training Social Media Marketing - Setup and Management on all SM platforms Email Marketing - Everything from setup to Newsletter Creations to management of lists and campaigns. HTML Newsletters. Mailchimp, Aweber, Constant Contact. Graphic Design - Web and Print Design - Signup Forms, Flyers, Brochures, Biz Cards, Google Ad Banners, Website Headers, Buttons and more. American English Dependability and Professionalism is always first! Other key areas of experience: Business Management Outsourcing Outsourcing Management Business Consulting Bookkeeping (Quickbooks) Copywriting and Content Creation Business & Management I have extensive experience in the area of business management and executive support. I have assisted in the growth of small companies and support of larger ones as they navigated through mergers and acquisitions. I have worked in various industries including Fitness, Financial, Investigative, and Waste Management. My offline career over these 20+ years has given me extensive knowledge in the areas of Business Management, Bookkeeping and Accounting, Customer Service, Sales, B2B Relations, Account Management, Office Management, Writing, Social Media Marketing, Internet Marketing, Print Design, Web Design, Blogging, eBook Creation, Article Marketing, and so much more. I have personally worked as a freelancer for the past 5 years and have helped many businesses manage their back office support needs. My knowledge is up-to-date, cutting edge, and always expanding. Look No Further! My multi-faceted background coupled with my dedication, loyalty and old school work ethics, will make me the perfect candidate for your position and I look forward to talking with you. I will reply to all reasonable interview requests. I am available for both small and large freelance assignments. I can wear many hats simultaneously and pull it off effortlessly.Complete office with high speed internet, 3 computers, fax, scanner, Skype, mobile. DON'T GO CHEAP! GO FOR QUALITY, EXPERIENCE, AND DEPENDABILITY!
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Trained in HTML, CSS, PHP, MySQL, Javascript, Flash, Photoshop, Illustrator, Word, Excel, Access Creating websites with Wordpress, Joomla and custom, with more than 8 years of experience. Google Certified Partner on Google AdWords. Managing and organizing your project from scratch. Able to do the necessary recruitments to complete the work.
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I have worked for a signs and graphic company doing t-shirt printing, designing for tarpaulin streamers, posters and stickers. My expertise lies in charcoal and pastel painting. Using Photoshop, I can do picture editing such as changing the background, cloning, etc. I can also do wordpress and html posting, aweber newsletter inputting, ebook publishing using mobipocket creator and data entry work using excel and word document.
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India - Last active: 1 day ago - Tests: 6 - Portfolio: 1
I am seeking opportunities of providing assistance for your business while keeping my skills sharp. I had been a hard working recruiter and business development executive for five years and have decided to utilize my time and skills by doing productive projects at home. I have provided different types of services including Virtual Assistance, Webinar ,Email Marketing, Web Research, Data Entry, Excel, email compilation,Linkedin Research, List building, Zoho CRM, Rapportive. I have subscription of top business directories like Hoovers and Zoom.
Business & HR Consultant
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If it's broken, I can see it immediately and implement strategies for change. Mental Health Managed Care direction, structure, and organization. Compliance/Credentialing/Staffing. Human Resource Executive with more than 20 years of experience in comprehensive HR direction including recruitment and retention; benefits administration; conflict resolution; change management; strategic planning; education and training; and diversity compliance and initiations. Demonstrated experience in cost containment strategies resulting in significant savings. Proven successes in talent acquisition, retention, and succession planning. Expertise in: • HR Department Startup * HRIS/HRM development and implementation • Employment Law • FMLA/ADA/EEO/WC • HR Policies & Procedures • Staff Recruitment & Retention • Employee Relations • Alternative Dispute Resolution (ADR) • Benefits Administration • HR Project Management • Orientation & On-Boarding • Training & Development • Performance Management • Organizational Development • Employee Handbook & Manual initialization * Recruitment and Retention
Finance Project Manager | IT UAT Tester | Freelancer
Romania - Last active: 5 days ago - Tests: 7 - Portfolio: 5
I am a Financial Analyst with more than 6 years experience within finance, beginner in recruitment and training with Master in Human Resources. Involved in team members evaluation, training and development plan. I have a hobby for software and hardware testing and always ready to work with projects. I am familiar with both Oracle and SAP technologies.
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~ Webgeek Extraordinaire ~ Everything Online: Backend To Frontend ~
Philippines - Last active: 1 day ago - Tests: 11 - Portfolio: 17
***TOP RATED Upwork Contractor! ***100% Job Success! ***5-star feedback! ***Upwork Verified: Fluent in written and spoken English ***Upwork Verified Identity and Phone Number ::: TopNotch Professional Writer (see samples in portfolio) ::: Excellent Executive, Management and People Skills ::: Human Resources and Recruitment Pro ::: Website Management Wiz ::: Accounting, Invoicing and Financial Analysis ::: Write/Ghostwrite, edit, proofread, format Kindle-ready eBooks ::: Master at creating Keynote presentations (Mac software) ::: Expert at using Pages (Mac software) for document processing ::: Proficient in the Best Spinner Software ::: Call Center Process Executive ::: Sales and Customer Service Executive ::: Certified International Teacher: English as a Second Language (ESL) ::: Six (6) Years of Online Management and Admin Assistance experience ::: Four (4) Years of Teaching Experience, English Grammar and Speech ::: Twelve (12) Years of Office and Executive Management ::: Fourteen (14) years of Youth Guidance and Leadership Experience ::: Teaching and Training for Social Development ::: Preparation and Writing of newsletters and bulletins ::: Article and Speech Writing on Various Topics ::: Email Management and Correspondence Pro ::: Research, Analysis and Evaluation ::: International Inbound and Outbound Calling ::: Adept with both Mac and Windows Operating Systems
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Tamar has more than 20 years of experience in the technology industry, with a solid back ground in Human Resources Recruiting and Project Management. Tamar has a well-rounded education with concentrations in editing, writing, website development and management and leadership and administration to include Recruiting, Training and Development. Tamar has experience in the website development and online marketing, automotive, healthcare and government sectors.

subset: commoncrawl


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Learn more about Belkin Grip Vue for iPhone 4, Clear:
Manufacturer: Belkin
Mfg Part#: F8Z642TTCLR
Sku: 216602493
See more in Accessories
Product Guides
|Clearly Unique
Tint & Texture
Protect your iPhone, without covering it up. The translucent sheen enhances the look of your device, while giving it maximum protection. And the innovative, flexible material combines grippability with visibility and a sleek, high-gloss finish.
Style & Substance
The thin material is durable and impact resistant, and the slim, form-fitting shape slips easily into your pocket or purse without bulk.
Customer Reviews of Belkin Grip Vue for iPhone 4, Clear
Don't get it for an iPhone 4 "S"....11/15/2011
This is an excellent product and I have had it in my iPhone 4, but made the mistake to think that it would work for the iPhone 4S. The phone is exactly the same size, but the placement of the mute and volume buttons is about 1/10 of an inch lower, which makes the case continuously push on the mute button. It just doesn't fit correctly. Tried in 2 iphone 4S's, white and black, from AT&T and Verizon. The 4S are all the same size. The case just doesn't work for those.


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This may go nowhere but it is better than nothing! I love the streak and do not want to have to get a Galaxy Note for £600, a new streak would be much better so let dell know how much you love them!
As I am fairly new here, I cannot post links but his twitter handle is above and mine is: @encima27, if you wanted to see the conversation.


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Sharp as adamantium, this limited-edition lithocel diptych from Marvel Comics features recreations of a classic and contemporary cover from the X-Men franchise.
Edition of 100. Numbered giclée on canvas. This piece is gallery wrapped and ready to hang. Includes Certificate of Authenticity.
This product has no reviews yet. Be the first to review this product. Write a review
Enjoy 10% off your first order*


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Holy cow, I wrote a book!
Next time you find yourself debugging in assembly language
(which for some of us is the only way we debug),
here are some machine code tricks you may wish to try out:
It has been pointed out that this works only for functions
that take zero stack parameters; otherwise,
your stack gets corrupted.
More generally, you can use 83 C4 XX 90 90
(ADD ESP, XX; NOP; NOP) where XX is the number of bytes
you need to pop. Personally, I don't remember the machine
code for these instructions so I tend to rewrite the CALL
instruction so it calls the "RETD" at the end of the function.
I prefer these single-byte patches to wholesale erasure with 90
because they are easier to undo if you realize that you want to
restore the code to the way it was before you messed with it.


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Obesity and related metabolic abnormalities, including inflammation and lipid accumulation in the liver, play a role in liver carcinogenesis. Adipocytokine imbalances, such as decreased serum adiponectin levels, are also involved in obesity-related liver tumorigenesis. In the present study, we examined the effects of pitavastatin - a drug used for the treatment of hyperlipidemia - on the development of diethylnitrosamine (DEN)-induced liver preneoplastic lesions in C57BL/KsJ-db/db (db/db) obese mice.
Male db/db mice were administered tap water containing 40 ppm DEN for 2 weeks and were subsequently fed a diet containing 1 ppm or 10 ppm pitavastatin for 14 weeks.
At sacrifice, feeding with 10 ppm pitavastatin significantly inhibited the development of hepatic premalignant lesions, foci of cellular alteration, as compared to that in the untreated group by inducing apoptosis, but inhibiting cell proliferation. Pitavastatin improved liver steatosis and activated the AMPK-α protein in the liver. It also decreased free fatty acid and aminotransferases levels, while increasing adiponectin levels in the serum. The serum levels of tumor necrosis factor (TNF)-α and the expression of TNF-α and interleukin-6 mRNAs in the liver were decreased by pitavastatin treatment, suggesting attenuation of the chronic inflammation induced by excess fat deposition.
Pitavastatin is effective in inhibiting the early phase of obesity-related liver tumorigenesis and, therefore, may be useful in the chemoprevention of liver cancer in obese individuals.
Hepatocellular carcinoma (HCC) is a serious healthcare problem worldwide because of its increasing morbidity and high mortality. Chronic inflammation of the liver and subsequent cirrhosis, which are highly correlated with hepatitis B and hepatitis C viruses infection and alcoholic liver disease, are the strongest risk factors for HCC development. Recent evidence also indicates that obesity and related metabolic abnormalities, especially diabetes mellitus and insulin resistance, raise the risk of HCC [1-4]. In obese individuals, high levels of free fatty acid (FFA) flux into the liver from excess adipose tissue. This in turn promotes hepatic steatosis and inflammation through the production of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-6, and is closely associated with liver carcinogenesis [5-7]. Aberrant lipogenesis in the liver, which is closely linked to obesity and metabolic syndrome, is also a dominant event in liver carcinogenesis and human HCC progression [8]. Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of the metabolic syndrome and a proportion of patients with this disease can progress to non-alcoholic steatohepatitis (NASH), which involves the risk of developing cirrhosis and HCC [9]. Therefore, in addition to lifestyle modification to reduce body weight, active pharmacotherapy is considered to be necessary for the management of NASH. For instance, metformin and thiazolidinediones, both of which increase insulin sensitivity, might be useful for the treatment of patients with NASH [10].
Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are widely used for the treatment of hyperlipidemia and have been shown to reduce the risk of cardiovascular disease [11]. Statins have recently also been suggested to be possible candidates for the management of NASH/NAFLD, which frequently coexist with hyperlipidemia and cardiovascular disease [12]. A pilot study revealed that treatment with atorvastatin decreases TNF-α serum levels and improves biochemical and histological features of disease activity in NASH patients with dyslipidemia [13]. The use of atorvastatin in hyperlipidemic patients complicated with NAFLD also improves serum transaminase levels and prevents hepatic fibrosis progression [14]. In a mice model, pitavastatin, a recently developed lipophilic statin, has been shown to ameliorate severe hepatic steatosis by enhancing hepatic free acid (FA) β-oxidation activity [15].
In addition to the lipid-lowering and anti-inflammatory effects, recent studies have revealed that statins appear to have anticancer and cancer chemopreventive properties [16,17]. A large cohort study showed that statin use is associated with a reduced risk of HCC in patients with diabetes [18]. Statins inhibit cell proliferation and induce apoptosis in human HCC-derived cells [19,20]. In addition, pitavastatin prevents obesity-related colorectal carcinogenesis by correcting adipocytokine imbalance and attenuating colonic inflammation in C57BL/KsJ-db/db (db/db) mice suffering from obesity and hyperlipidemia [21]. These findings suggest the possibility that long-term use of statins may also be effective for preventing the progression of obesity-related liver tumorigenesis. Our recent study showed that diethylnitrosamine (DEN)-induced liver tumorigenesis is significantly enhanced in db/db mice [22]. In the present study, we examined the effects of pitavastatin on the development of DEN-induced hepatic preneoplastic lesions, foci of cellular alteration (FCA), while focusing on the improvement of liver steatosis and inflammation using a db/db mice model.
Animals and chemicals
Four-week-old male db/db mice were obtained from Japan SLC Inc. (Shizuoka, Japan) and were humanely maintained at the Gifu University Life Science Research Center in accordance with the Institutional Animal Care Guidelines. DEN was purchased from Sigma Chemical Co. (St. Louis, MO, USA). Pitavastatin was obtained from Kowa Pharmaceutical Co. (Tokyo, Japan).
Experimental procedure
The animal experiment was approved by the Committee of Institutional Animal Experiments of Gifu University [22]. At 5 weeks of age, all 36 mice were administered tap water containing 40 ppm DEN for the first 2 weeks of the experiment. After DEN treatment, Groups 2 (n = 12) and 3 (n = 12) were given a basal diet (CRF-1, Oriental Yeast Co., Tokyo, Japan) containing 1 and 10 ppm pitavastatin, respectively, until the end of the experiment. Group 1 (n = 12) acted as the control and was fed only a basal diet throughout the experiment. At 21 weeks of age (after 14 weeks of pitavastatin treatment), all the mice were sacrificed to analyze the development of FCA. Since neither C57B6 nor C57BL/KsJ-+/+ mice - the genetic controls for db/db mice - develop FCA and liver neoplasms by DEN administration during this period [22], control experimentation using these mice was not conducted in the present study.
Histopathology and immunohistochemical analysis for PCNA
Maximum sagittal sections of each lobe (6 sublobes) were used for histopathological examination. For all experimental groups, 4 μm-thick sections of formalin-fixed and paraffin-embedded livers were stained with hematoxylin & eosin (H&E) for histopathology. The presence of FCA, which are phenotypically altered hepatocytes showing swollen and basophilic cytoplasm and hyperchromatic nuclei, was judged according to the criteria described in a previous study [23]. The multiplicity of FCA was assessed on a per unit area (cm2) basis.
Immunohistochemical staining of proliferating cell nuclear antigen (PCNA), a G1-to-S phase marker, was performed to estimate the cell proliferative activity of FCA by using an anti-PCNA antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA) and the labeled streptavidin-biotin method (LSAB kit; DAKO, Glostrup, Denmark) [22]. On the PCNA-immunostained sections, the cells with intensively reacted nuclei were considered to be positive for PCNA, and the indices (%) were calculated in 20 FCA randomly selected from each group.
Protein extraction and western blot analysis
Equivalent amounts of extracted mice liver proteins (20 μg/lane) were examined by western blot analysis [22]. Previously described primary antibodies for AMP-activated kinase-α (AMPK-α), phosphorylated AMPK-α (p-AMPK-α), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were used [21], with GAPDH serving as a loading control. The primary antibody for Bad was purchased from Cell Signaling Technology (Beverly, MA, USA). The intensities of the blots were quantified with NIH Image software version 1.62.
RNA extraction and quantitative real-time reverse transcription-PCR
Total RNA was isolated from the livers of experimental mice using the RNAqueous-4PCR kit (Ambion Applied Biosystems, Austin, TX, USA) and cDNA was amplified from 0.2 μg of total RNA using the SuperScript III First-Strand Synthesis System (Invitrogen, Carlsbad, CA, USA). Quantitative real-time reverse transcription-PCR (RT-PCR) analysis was performed using specific primers that amplify TNF-α, IL-6, Bcl-2, Bad, and GAPDH genes, as described previously [21,24].
Clinical chemistry
The blood samples, which were collected at the time of sacrifice after 6 hours of fasting, were used for chemical analyses. The serum TNF-α (Shibayagi, Gunma, Japan), IL-6 (IBL, Gunma, Japan), adiponectin (Otsuka, Tokyo, Japan), and leptin (R&D Systems, Minneapolis, MN, USA) levels were determined by enzyme immunoassay according to the manufacturers' protocol. The serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), free fatty acid (FFA), total cholesterol, and triglyceride were measured with a standard clinical automatic analyzer (type 7180; Hitachi, Tokyo, Japan).
Hepatic lipid analysis
Approximately 200 mg of frozen liver was homogenized, and lipids were extracted using Folch's method [25]. The triglyceride levels in the liver were measured using the triglyceride E-test kit (Wako Pure Chemical Co., Osaka, Japan) [22]. To visualize the intrahepatic lipids, Oil red O staining was utilized based on the standard procedure for frozen liver sections.
Statistical analysis
The results are presented as means ± SD, and were analyzed using the GraphPad Instat software program version 3.05 (GraphPad Software; San Diego, CA) for Macintosh. Differences among the groups were analyzed by either one-way ANOVA or, as required, by two-way ANOVA. When the ANOVA revealed a statistically significant effect (P < 0.05), each experimental group was compared with the control group by using the Bonferroni multiple comparisons test. The differences were considered significant when the two-sided P value was < 0.05.
General observations
As presented in Table 1, administration of pitavastatin significantly (P < 0.01, Group 1 vs. Groups 2 and 3) and dose dependently (P < 0.05, Group 2 vs. Group 3) decreased the value of body mass index (BMI). The body weight and relative weights of liver and white adipose tissue (periorchis and retroperitoneum) of the mice that received 10 ppm pitavastatin were slightly lower than those of the untreated control mice, but the differences were not significant. During the experiment, pitavastatin administration did not cause any clinical symptoms for toxicity. Histopathological examination also revealed the absence of pitavastatin toxicity in the liver, kidney, and spleen (data not shown).
Table 1. Body, liver, kidney and white adipose tissue weights of the experimental mice
Effects of pitavastatin on DEN-induced liver preneoplastic lesions in db/db mice
Liver preneoplastic lesion FCA, which possesses basophilic cytoplasm and hyperchromatic nuclei (Figure 1A), was observed in the livers of mice from all groups at the termination of the experiment. Treatment with a high dose (10 ppm) of pitavastatin significantly inhibited the development of FCA in comparison to both the untreated control mice (P < 0.001) and low dose (1 ppm) of pitavastatin-treated mice (P < 0.05). Treatment with 1 ppm pitavastatin also demonstrated a tendency to suppress the development of FCA - the inhibition rate being 29% - in comparison to the untreated control mice, but the difference did not reach a statistical significance (Figure 1B).
Figure 1. Effects of pitavastatin on DEN-induced FCA in db/db mice. (A) A representative photograph of FCA induced by DEN in db/db mice (H&E staining). Scale bar, 100 μm. (B) Average number of FCA in all groups (pitavastatin-untreated, 1 ppm pitavastatin-treated, and 10 ppm pitavastatin-treated groups). Each column represents the mean ± SD. * P < 0.05 vs. 1 ppm pitavastatin-treated group and ** P < 0.001 vs. the untreated group, respectively.
Effects of pitavastatin on the cellular levels of Bad and Bcl-2 and the proliferation activity in FCA of DEN-treated db/db mice
We next examined the effects of pitavastatin on the induction of apoptosis in the liver and the inhibition of cell proliferation in FCA of DEN-treated db/db mice. Treatment with both low and high doses of pitavastatin increased the protein levels of Bad, a pro-apoptotic Bcl-2 family member, in the liver of experimental mice (Figure 2A, P < 0.05). The mRNA levels of this molecule were also increased by 1 ppm pitavastatin administration (Figure 2B, P < 0.05). On the other hand, pitavastatin treatment induced a marked decrease in the levels of an anti-apoptotic molecule Bcl-2 mRNA (Figure 2B, P < 0.05). In addition, as shown in Figure 2C, the mean PCNA-labeling indices for FCA in mice treated with 1 ppm (23.9 ± 7.7%) and 10 ppm (16.6 ± 4.0%) pitavastatin were significantly lower than that in the mice which received only DEN (47.7 ± 11.0%; P < 0.001 for each comparison). These findings indicate that pitavastatin significantly suppresses FCA, at least in part, by inducing apoptosis and by reducing cell proliferation.
Figure 2. Effects of pitavastatin on the expression levels of Bad and Bcl-2 in the liver and cell proliferation in FCA induced by DEN in db/db mice. (A) The total proteins were extracted from the livers of experimental mice and the expression levels of the Bad protein were examined by western blot analysis (upper panel). The intensities of the blots were quantified by densitometry (lower panel). GAPDH antibody served as a loading control. Two lanes represent protein samples obtained from 2 different mice in each group. Repeat western blots yielded similar results. Values are the means ± SD. * P < 0.05 vs. the untreated group. (B) The total RNAs were isolated from the livers of experimental mice and the expression levels of Bcl-2 and Bad mRNAs were examined by quantitative real-time RT-PCR using specific primers. The expression levels of each mRNA were normalized to the level of GAPDH mRNA. Values represent the means ± SD. * P < 0.05 vs. the untreated group. (C) Representative pictures of the PCNA-immunohistochemical analysis of FCA (circled) developed in the livers of Groups 1, 2, and 3 (left panels). The PCNA-labeling indices of FCA developed in the livers of Groups 1 through 3 were determined by counting the PCNA-positive nuclei in FCA (right panel). Scale bars, 200 μm (no treatment) and 100 μm (1 and 10 ppm pitavastatin). * P < 0.001 vs. the untreated group.
Effects of pitavastatin on hepatic steatosis, activation of AMPK-α protein in the liver, and serum levels of FFA, total cholesterol, and triglyceride in DEN-treated db/db mice
Accumulation of lipids in the liver, which is caused by dyslipidemia, is considered to play a role in liver tumorigenesis [5,6]. Therefore, we examined whether pitavastatin improved hepatic steatosis and hyperlipidemia in the experimental mice. Examination of Oil red O stained sections revealed severe hepatic steatosis in the DEN-treated db/db mice; however, the mice's conditions were markedly improved by pitavastatin administration (Figure 3A, upper panels). Similar to the histological findings, the levels of intrahepatic triglyceride were also significantly reduced by administration of pitavastatin (Figure 3A, lower panel, P < 0.001). Western blot analysis demonstrated that pitavastatin significantly phosphorylated (i.e., activated) AMPK-α - a critical kinase that monitors cellular energy status [26] - in the livers of the experimental mice (Figure 3B, P < 0.05). In addition, treatment with both low (P < 0.01) and high (P < 0.001) doses of pitavastatin decreased the serum levels of FFA, while the levels of total cholesterol and triglyceride were not affected by administration of this agent (Figure 3C).
Figure 3. Effects of pitavastatin on hepatic steatosis, activation of the AMPK-α protein in the liver, and serum levels of FFA, total cholesterol, and triglyceride in DEN-treated db/db mice. (A) Frozen liver sections from experimental mice with or without pitavastatin treatment were stained with Oil red O to show steatosis (upper panels). Hepatic lipids were extracted from the frozen livers of these mice, and the triglyceride levels were measured (lower panel). Values are the means ± SD. * P < 0.001 vs. the untreated group. (B) The total proteins were extracted from the livers of experimental mice and the expression levels of the AMPK-α and p-AMPK-α proteins were examined by western blot analysis (upper panel). The intensities of the blots were quantified by densitometry (lower panel). GAPDH antibody served as a loading control. Two lanes represent protein samples obtained from 2 different mice in each group. Repeat western blots yielded similar results. Values are the means ± SD. * P < 0.05 vs. the untreated group. (C) The serum concentrations of FFA, total cholesterol, and triglyceride in all groups. Values are the means ± SD. * P < 0.01 and ** P < 0.001 vs. the untreated group, respectively.
Effects of pitavastatin on serum levels of AST, ALT, adiponectin, and leptin in DEN-treated db/db mice
The serum levels of AST, ALT, adiponectin, and leptin in the experimental mice are listed in Table 2. The elevated serum AST and ALT levels, which might increase due to severe steatosis (Figure 3A), were significantly decreased by treatment with both low (P < 0.001) and high (P < 0.05) doses of pitavastatin. The serum leptin levels after pitavastatin administration demonstrated a downward trend, but the differences were not significant. However, treatment with this agent markedly increased the serum levels of adiponectin when compared to the control mice (P < 0.05).
Table 2. Serum levels of AST, ALT, adiponectin, and leptin in the experimental mice
Effects of pitavastatin on serum TNF-α levels and hepatic expression of TNF-α and IL-6 mRNAs in DEN-treated db/db mice
Chronic inflammation induced by excessive production of storage lipids is closely associated with obesity-related liver carcinogenesis [5-7]. Therefore, the effects of pitavastatin on the serum levels of TNF-α, a central mediator of chronic inflammatory disease, and on the expression of TNF-α and IL-6 mRNAs in the liver of DEN-treated db/db mice were examined. Administration of both doses of pitavastatin significantly decreased serum TNF-α levels (Figure 4A, P < 0.05). Further, quantitative real-time RT-PCR revealed that the expression levels of TNF-α and IL-6 mRNAs in the livers of experimental mice were also significantly decreased after pitavastatin treatment (Figure 4B, P < 0.05, respectively), suggesting that pitavastatin attenuated liver inflammation in obese db/db mice.
Figure 4. Effects of pitavastatin on the serum levels of TNF-α and the expression levels of TNF-α and IL-6 mRNAs in the liver of DEN-treated db/db mice. (A) The serum concentration of TNF-α was measured by enzyme immunoassay. Values represent the means ± SD. * P < 0.05 vs. the untreated group. (B) The total RNAs were isolated from the livers of experimental mice and the expression levels of TNF-α and IL-6 mRNAs were examined by quantitative real-time RT-PCR using specific primers. The expression levels of each mRNA were normalized to the level of GAPDH mRNA. Values represent the means ± SD. * P < 0.05 vs. the untreated group.
Discussion and Conclusions
Statins lessen hyperlipidemia by competitively inhibiting HMG-CoA reductase, and thus, they are effective in preventing cardiovascular disease [11]. On the other hand, many studies have shown the anticancer and cancer chemopreventive effects of statins, such as the inhibition of cell proliferation, promotion of apoptosis, and inhibition of inflammation, angiogenesis, and metastasis [16,17,19,20]. The anticancer effects of statins also involve the inhibition of geranylgeranylation, primary of the Rho proteins [16,17]. These findings suggest the possibility of statins playing a role of cancer chemopreventive agents for certain malignancies.
The results of the present study clearly indicated that pitavastatin, which is widely used for the treatment of patients with hyperlipedemia, effectively prevents the development of DEN-induced liver preneoplastic lesions in obese db/db mice (Figure 1B). This is the first report that shows the preventive effect of statin analog on the development of obesity-related liver tumorigenesis. The unfavorable effects of obesity and related metabolic abnormalities are serious global healthcare problem. Among them, the promotion of HCC by obesity [1-4] is one of the critical issues that need to be addressed in the management of this malignancy. Therefore, our present finding seems to be clinically significant when considering the prevention of HCC in obese people, who are at an increased risk of developing HCC.
The suppressive effect of pitavastatin on the development of obesity-related liver tumorigenesis was most likely associated with the induction of apoptosis in the liver (Figures. 2A and 2B) and the inhibition of proliferation in FCA (Figure 2C). This inhibition was also associated with the improvement of hepatic steatosis (Figure 3A) and the attenuation of inflammation (Figure 4) because excess accumulation of lipids in the liver accelerates hepatic tumorigenesis by inducing a chronic inflammatory reaction [5-7]. Pitavastatin mainly ameliorates hepatic steatosis by decreasing serum FFA levels (Figure 3C) since the high influx of FFA into the liver plays a major role in hepatic fat accumulation [5,6]. In addition, activation of AMPK-α by pitavastatin in the liver (Figure 3B), which increases FA oxidation, decreases FA synthesis, and improves hyperlipidemia [26], also contributes to the inhibition of lipid deposition in the liver. Further, these findings are significant when considering the prevention of obesity-related carcinogenesis because AMPK is regarded as a metabolic tumor suppressor and a promising target for cancer prevention and therapy [27]. AMPK activity is associated with the inhibition of lipogenesis, which has a pathogenic and prognostic significance for HCC [8], induction of apoptosis, and suppression of cell growth in human HCC-derived cells [28]. Pitavastatin has also been shown to inhibit obesity-related colorectal carcinogenesis through the activation of AMPK-α in the colonic mucosa [21].
In the present study, lipid-lowering effects of pitavastatin were positive on serum FFA but not significant on total cholesterol and triglyceride in DEN-treated db/db mice (Figure 3C). These findings are consistent with the results of a recent study indicating more high doses of pitavastatin (20 and 40 ppm) did not significantly decrease the serum levels of total cholesterol and triglyceride in Min mice, which show a hyperlipidemic state [29]. On the contrary, Egawa et al. [15] demonstrated that pitavastatin administration resulted in a significant reduction in the levels of plasma triglyceride and total cholesterol in aromatase-deficient mice. Treatment with both 1 and 10 ppm pitavastatin for 8 weeks also reduced serum levels of total cholesterol, but not triglyceride, in azoxymethane-treated db/db mice [21]. These reports [15,21,29], together with the results of the present study, suggest that effects of pitavastatin on plasma lipids might depend on the animal strain and experimental procedure. In addition, it has been shown that pitavastatin potently inhibits de novo cholesterol synthesis without affecting serum lipid levels [30,31]. In rodents, cholesterol synthesis enzymes were remarkably induced by feedback regulation [32], suggesting that the effects of pitavastatin on reduction of plasma lipid and inhibition of HMG-CoA reductase activity might be masked by such feedback regulation.
Increases in TNF-α and IL-6 levels, which are accompanied by lipid accumulation in the liver, are involved in obesity-related liver carcinogenesis [5-7]. Therefore, reduction of serum TNF-α levels (Figure 4A) and inhibition of the expression of TNF-α and IL-6 mRNAs in the liver (Figure 4B) by pitavastatin are important in preventing obesity-related liver tumorigenesis. These findings are consistent with previous reports that pitavastatin significantly suppresses inflammation- and obesity-related mouse colon carcinogenesis by attenuating chronic inflammation [21,33]. The effects of pitavastatin on decreasing the levels of TNF-α might be largely dependent on the reduction of BMI (Table 1) and serum FFA levels (Figure 3C). These phenomena may also be associated with the improvement of adipocytokine imbalance (Table 2) because TNF-α has been shown to decrease the levels of adiponectin, which is secreted by the adipose tissue, while increasing the levels of leptin in the adipocytes [34,35]. Moreover, up-regulation of serum adiponectin levels (Table 2) also plays a role in attenuating inflammation because this adipocytokine possesses the ability to down-regulate the production of TNF-α and IL-6 [36]. Adiponectin alleviates hepatic steatosis and ALT abnormalities in alcohol-induced fatty liver mice model and in ob/ob mice, a NAFLD mice model, by enhancing FA oxidation, while decreasing FA synthesis and TNF-α production in the liver [37]. Hypoadiponectinemia enhances the progression of steatosis and hepatic tumor formation in a mice model of NASH [38]. In addition, adiponectin inhibits cell proliferation and induces apoptosis in human HCC-derived cells by inducing AMPK activation [39]. Therefore, the elevation of adiponectin and activation of AMPK might be effective for the prevention of obesity-related tumorigenesis.
Hepatotoxicity is one of the critical concerns in treatment with statins. In the present study, however, pitavastatin did not cause significant toxicity in the liver as determined by histological examination. The serum aminotransferase (ALT and AST) levels were also decreased by treatment with this agent (Table 2). The safety of statins for patients with liver dysfunction has also been reported in several clinical trials [40]. In addition, patients with chronic liver disease, including NAFLD/NASH and HCV infection, may benefit from statins because cardiovascular risk is likely to be high in these diseases [12,41]. Therefore, statin use might be a promising therapy for NASH patients who have an increased risk of HCC [9], although periodic monitoring of serum aminotransferase levels should be conducted. The result of a recent epidemiological study revealing a significant relationship between the risk reduction of HCC and statin use among diabetic patients [18] may also encourage statin therapy for patients with chronic liver disease, especially NASH patients, who frequently have hyperlipidemia as well as insulin resistance.
Finally, it should be noted that the results of recent studies indicating that supplementation with branched-chain amino acids and acyclic retinoid, both of which exert chemopreventive effects on the development of HCC in clinical trials [3,42], suppresses DEN-induced liver tumorigenesis in db/db mice by improving hepatic steatosis and attenuating chronic inflammation [22,43]. In summary, the results of the present study, together with those of the cited reports [22,43], suggest that the prevention of liver carcinogenesis by targeting hepatic steatosis, chronic inflammation, and adipocytokine imbalance, through either pharmaceutical or nutritional intervention, might be a promising strategy for obese individuals who are at an increased risk of developing HCC. Pitavastatin appears to be a potentially effective candidate for this purpose since it can improve liver steatosis and attenuate inflammation, at least in part, through the activation of AMPK-α and up-regulation of adiponectin.
List of abbreviations used
ALT: alanine aminotransferase; AMPK: AMP-activated kinase; ANOVA: analysis of variance; AST: aspartate aminotransferase; BMI: body mass index; DEN: diethylnitrosamine; FA: fatty acid; FCA: foci of cellular alteration; FFA: free fatty acid; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; H&E: hematoxylin & eosin; HCC: hepatocellular carcinoma; HMG-CoA: 3-hydroxy-3-methylglutaryl coenzyme A; IL: interleukin; PCNA: proliferating cell nuclear antigen; RT-PCR: reverse transcription-PCR; TNF-α: tumor necrosis factor-α.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
MS, YY, and TT conceived of the study, participated in its design, and drafted the manuscript. MS, YY, HS, MK, DT, AB, and TO performed in vivo experiment. TK performed statistical analysis. HT and HM helped to draft the manuscript. All authors read and approved the final manuscript.
This work was supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports and Culture of Japan (No. 22790638 to M. S. and No. 21590838 to H. M.) and by Grant-in-Aid for the 3rd Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan.
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Pre-publication history
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Star Wars: The Clone Wars - "The Disappeared" - Season 6 photo of Jar Jar Binks voiced by Ahmed Best, Mace Windu voiced by T.C. Carson and Savatte voiced by Paul Nakauchi.
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New York Idealist Grad Fair
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A Second Shift In the previous 3 parts we established that a significant shift took place in the late 19th and early 20th century. This initial shift in modernity has subsequently created the possibility of a second, more contemporary, move that I want to explore. Taylor provides the context of this potential when he says: In earlier … Continue reading
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How We Imagine A 'Nation' part 3
In the shadow of the Sochi Olympics and the unfolding tension in the Ukraine, we are exploring the theme/thesis that: 'Nation' is both sovereign and transcendent. 'Nation' is both a social imaginary and an emergent reality. [Trust me – I am going somewhere with this] Benedict Anderson explains that the notion of imagined communities was … Continue reading
Imagining a 'Nation' part 2
In part 1 I introduced a theme/thesis for this series of posts: 'Nation' is both sovereign and transcendent. 'Nation' is both a social imaginary and an emergent reality. Charles Taylor utilizes the term 'social imaginary' to refer to god-like capacity described by Anderson. The term encompasses a threefold meaning: First is the way that ordinary … Continue reading
Imagining a 'Nation' part 1
Watching the Olympics was different for me this time. During the past four years I have been in a PhD program and have burrowed down into topics that have deeply impacted me. Within one of my cognate fields (non-core studies) I addressed the issue of nationalism and the modern imaginary. The news about events that … Continue reading
Church & State are Married in a Civil Union
Originally published at HBC A good questions can get to the heart of an issue – or expose the underlying assumptions that lie behind an issue. I learned early on in ministry to ask a simple question about marriage: If I as an ordained minister perform a wedding ceremony for a couple, but they have … Continue reading


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Art Briefs: 10.01.08
Local sculptor's work dedicated
World renowned wildlife sculptor Kent Ullberg, of North Padre Island, recently dedicated "Canyon Watch", his sculpture of a majestic cougar, at a North Mesa roundabout in Los Alamos, N.M. The dedication was sponsored by the Los Alamos Art in Public Places Board, which visited Los Alamos galleries and reviewed sculptor portfolios before selecting Ullberg's design.
Life-sized art installation continues
The multi-media art installation featuring life-sized sculpture combined with drawing, photography and video by Amorette V. Garza and Shreepad Joglekar, Tele-Caste System: Site (Un)scene, continues through Oct. 10 at K Space Contemporary, 415 Starr St. Free. Hours: 11 a.m. to 5 p.m., Wednesday - Saturday.Information: 887-6834 or www.kspacecontemporary.org.
Converging Pathways at Galeria Galvan
The Nexus Art Collective, a group of local artists, will open Converging Pathways, its premiere exhibition, with a reception from 4 to 6 p.m. Saturday at Galeria Galvan in Heritage Park. A wide range of media and styles will be on display through Nov 1. The artists are: Dan Davis, Jeanine McCain, David Longnecker, Bernardo Diaz, Eva Cantwell, Shawna Leahey, Sheila Gritte, Luis Corpus, Mary Terry, Grace Barraza-Vega and Clarita Fajutag. Free. Hours: 8:30 a.m. to 5 p.m., Monday - Friday; 11 a.m. to 2 p.m., Saturday. Information: 442-4835.
Annual breast cancer exhibit
A reception for the Third Annual Breast Cancer Art Exhibit, featuring the work of Carroll High School art students, will be from 5 to 7 p.m. Oct. 9 at the Art Center of Corpus Christi. The exhibit will be on display through October in honor of Breast Cancer Awareness Month. Free. Hours: 10 a.m. to 5 p.m. Tuesday - Saturday. Information: 884-6406.
Go Red for Women exhibit
The Go Red for Women Art Exhibit will kick off with a reception open to the public Dec. 11 at the Art Museum of South Texas, 1902 Shoreline Blvd. The exhibit will benefit the American Heart Association's Go Red For Women campaign. Artists are encouraged to apply to be in the show by filling out an application by Oct. 10 at the American Heart Association, 500 N. Shoreline Blvd., at the Art Museum of South Texas or online at www.americanheart.org/grfwartcontest. All media will be accepted.
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Please join the Google group http://groups.google.com/d/forum/ipppodcastplayer to become a beta tester. Thank you!
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This is ads supported app. With in-app purchase ads can be removed. There's no functionality difference between ads supported and ads free version.
- Fully automated download. Just turn on the auto download, this app will download any new episode available for you.
- Offline playback of audio and video, save your data consumption
- Multiple playlist support for better organizing your podcast playing
- Synchronize between devices
- Support home screen widget, lock screen widget, and expandable notification controls. Your favorite podcast is just at the tip of your fingers.
- Import and export podcast subscription using OPML format
- Ability to save download to SD card
- Multiple language support: Chinese, Czech, English, French, German, Italian, Polish, Portuguese, Russian, Spanish
- Has built-in Tablet layout. One app for all screen sizes.
- Chromecast support
- Android wear support
Built-in Media Player
- Plays audio/video podcast
- Streams audio/video over network (wifi/cell)
- Remembers play position
- Bluetooth support
- Play in background
- Sleep timer to stop audio player after you sleep
- Features a car mode for easy and quick playback control
Download Management
- Automatically fetch feeds on a configurable interval
- Automatically download new episode
- Automatically deletes downloaded podcast that has been listened to
- Automatically synchronizes between downloads and playlist
- Multiple playlist support for better organizing your podcast playing. Create as much playlists as you can.
- Support audio/video playlist for continuous play
- Sortable playlist plus manual drag and sort ability for easy playlist management
- Fully configurable. A lot configuration options to meet your specific needs.
- Two level settings, global settings and individual podcast settings, to fine tune the settings
- Support themes: light theme & dark theme
- Configurable home screen widget to fit your beautiful wallpaper
Note for users with Android KitKat or above:
If you just updated to KitKat and use the SD card as download location, please go to the settings of this app and reset the download location to SD card.
For Lollipop users: Lock screen widget is no longer supported. Please use the notification on lock screen instead.
What's New
Pocket Casts
AUDIO EFFECTS: Always dreamed of playing more podcasts, but don't have time? Use our silence removal feature to dynamically speed up podcasts. Podcasters talking too softly? Give them a (volume) boost!
AUTO DOWNLOAD: Pick any podcast you like, set it to auto-download while you sleep. Save your cell data for when it matters.
UP NEXT: Quickly see what's coming up next, and re-arrange episodes to your liking.
SYNC & BACKUP: Sync your subscriptions, playback and filters between Android and iOS devices, and backup your data to the cloud. You can now drop your phone in a toilet and not lose your podcasts. We dare you.
FILTERS: Want a list of every unplayed, downloaded podcast? Right here. How about a list of video episodes that you haven't downloaded yet? Easy. Sorting your shows by custom categories? Done.
CHROMECAST: Cast your episodes straight to your TV with a single tap.
STORAGE: Set your episode storage location and how many episodes of a podcast you want to keep. We'll clean up the rest. News mode added for the contemporaries among us.
VARIABLE SPEED: Play audio all the way from 0.5x to 3.0x, no dodgy plugins to download, no fuss, just pure unadulterated speed.
MATERIAL DESIGN: We work day (and sometimes even night) so that your podcast app always feels up to date and modern. Come to the promised land: where subtle animations, vivid colors and a well designed app meet at last.
VIDEO & AUDIO: Pocket Casts lets you toggle video podcasts to audio and back again for when you're on the move.
CONTROL: Control your podcasts from the widget, notification center, lock screen, headphones, Bluetooth, Android Wear and even Pebble with custom skip intervals.
SLEEP TIMER: Fall asleep to your favorite boring podcasts.
THEMES: Dark and light themes, to suit your location and mood.
REFRESH: Instantly refresh all your podcasts before other apps even have a chance to do 1! Our server monitors your podcasts, so your phone doesn't have to.
OPML: Import or export your subscriptions easily to and from our app.
TABLET SUPPORT: It's an equal opportunity app, with support for both phones and tablets.
SHARING: Share your favorite podcasts, episodes and positions in episodes. Sharing is caring.
DISCOVER: Find great new content with curated featured podcasts, currently trending podcasts, networks and much more.
SUPPORT: Provided via email, Twitter, Facebook and Google+. Heck we occasionally even log in to Reddit to say hello. We also have a rocking User Guide for those that prefer a little hand-holding.
There are many more powerful, straight forward features help you make Pocket Casts yours and in case you were wondering, here's what Pocket Casts DOESN'T have: ads, episode limits, pushy trials, feature bloat or plugins.
It. Just. Works.
Player FM Podcast App
Features: Video playback (now in beta!), Companion web app, Tablet+Chromecast+Android Wear, Speed control, Sleep timer, Material design, Search 3 million episodes, Personal recommendations, Homescreen+lockscreen widgets, Interactive notification, Play local files, Flexible settings.
Android Central: "Just looks amazing ... packed with useful features ... tell it what you're interested in and watch it work its magic"
LifeHacker: "Guides you to smart, interesting podcasts"
Tested: "Right from the start, I found the experience of using Player FM enjoyable"
All About Android: Winner, app arena http://goo.gl/wXjkIW
GigaOm: "Makes podcasts look cool again"
Minimal permissions are used - some background here: http://goo.gl/hYHVSx
Like Spotify or YouTube, your subscriptions sync in the cloud so you can setup once for life and use the app on multiple devices. The cloud model also saves you bandwidth and battery by fetching feeds in the server instead of checking every publisher's server for updates.
Get fresh recommendations on your favorite topics, ready for immediate streaming or download. Our catalogue goes deep, with 500+ niche topics to follow. Not just "Tech", but "Android", "Gaming", "Programming", etc. Follow your favorite TV show, sport, industry, etc.
Subscriptions and Play Later lists proactively downloaded for offline use, with auto-cleanup. All highly configurable.
Browse shownotes for all episodes in the publisher's feed and immediately stream any episode or save it for later even if you're not subscribed. You can even search full shownotes for over 3 million episodes.
Resume where you left off, mark played, browse your history.
Your subscriptions import and export as OPML in case you ever want to move to another app #sadface.
Chromecast, Android Wear, voice activation ("OK Google search for Android on Player FM"), Samsung Gear S notifications, enhanced sound on Dolby® Digital Plus™ compatible devices, LG Quick Circle™, Music Boss integration on Android Wear, Podlove Subscribe button.
Manage up to 20 subscriptions, enable Gold trial directly in the app for unlimited subscriptions + other benefits (Gold launches later this year but you can activate the trial now).
We're always working to improve the app. We love your feedback and respond quickly to every mail, so get in touch at email@example.com if you have any questions or suggestions! We're also active and respond on Twitter, Google+, Facebook. Join our Google+ beta community for news and early access to new features (currently Play Later re-ordering). http://goo.gl/gW4zxn
BeyondPod Podcast Manager
With nearly 3 million downloads, BeyondPod's streamlined interface and powerful controls give you
easy access to millions of audio and video episodes from small publishers like local radio stations to "big name" publishers like CNN, ESPN, BBC, CBC.
• ACCESS hundreds of thousands of free audio and video podcasts from all over the world.
• PLAY your content everywhere - online or offline.
• CUSTOMIZE your playlist the way you like.
This is a "Lite" version with 7 day full feature trial
Discover thousands of free audio and video shows from all over the world. Search for feeds or browse our extensive library of popular Podcasts.
Import your own files (music, audio books, lectures & more) and play them with our powerful player.
Adjust the playback speed, set a sleep timer, use "volume boost", or "cast"
to your TV - we have all the tools to enjoy your content the way you like it.
BeyondPod's configurable "skip/replay" buttons let you easily skip over
parts that you're not interested in, or replay parts you missed.
Cast your audio or video episodes to your TV via Chromecast directly from
BeyondPod's Smart Playlists automatically create playlists based on your listening
preferences. You can build a playlist for your daily commute, another for 'At the Gym' or 'On the Train' etc.
Decide which episodes to download, when and over which connection as well as how long
to keep old episodes. Choose to automatically update a single feed, all the feeds in a
given category, or all feeds.
Save bandwidth and battery by scheduling your downloads at a specific time, only when connected to WiFi,
or only when the phone is charging.
Resizeable Home Screen Widget gives you quick access to your player and playlist. Start your favorite
Smart Playlists directly from your home screen.
Complete Feedly integration allows you to access older episodes that are no longer part of the publisher's feed.
You can also easily import your Feedly subscriptions as well as synchronize read and starred posts between a PC and your phone.
Like to live on the cutting edge? Subscribe to our BETA channel on Google Play!
Details at: http://www.beyondpod.mobi/Android/BETA
DoggCatcher Podcast Player
-Lifehacker finds DoggCatcher to be "The Best Podcast Manager for Android"
-Android Central's Editors' Choice podcatcher of the year
-Android Central's Readers' Choice runner up podcatcher of the year
-ChromeCast support
-Easy to subscribe new podcasts
-Auto download and cleanup of media files
-Offline playback of audio and video podcasts
-Customizable audio playlists
-Supports devices of all sizes
-Highly configurable
-Build in variable speed playback
-Home screen widget for easy access to playback controls
-Podcast categorization
-Automatically updates podcasts on your schedule
-Automatically download new media
-Automatically deletes media
Add podcasts by
-Browsing Top 100 DoggCatcher podcasts
-Personalized recommendations
-Searching podcast and news directories
-Importing from OPML
Integrated Audio/Video Player
-Plays downloaded audio/video
-Streams audio over network (wifi/cell)
-Remembers play position of media file
-Plays video formats supported by Android - http://developer.android.com/guide/appendix/media-formats.html
-Audio playlist for continuous playback of new media
-Video/News playlists for easy navigation of new media
Community and support
-Frequently updated - http://mantis.doggcatcher.com/changelog_page.php
-Very active user community in forums - http://www.doggcatcher.com/forum
-Support via forums and email
-Battery/data plan friendly - can limit downloads based on network/power connections
-Media download queue can be viewed and managed
-Bluetooth support (A2DP/AVRCP)
-Supports authenticated feeds (username/password)
For any questions about application permissions, please see http://www.doggcatcher.com/permissions
Community and support at doggcatcher.com
Public Radio & Podcast
With home screen widget, your favorite radios/podcasts are just at the tip of your fingers.
This is ads supported app. With in-app purchase ads can be removed. There's no any functionality difference between ads supported and ads free version.
- Live streams from 300+ public radio stations
- Restart the audio play from where it is left before
- Pause/resume audio play on incoming phone
- Ability to skip the beginning part of the podcast
- Set your favorite radio station as alarm
- Sleep mode to turn off radio after scheduled time
- Play in background
- Download and play it any time you want
- Instance search as you type
- Ability to save download to SD card
- Ability to add new radio station manually
- Ability to add new podcast manually
- Home screen widget for easy play control and quick access
- Chromecast support
Note for users with Android KitKat or above:
If you just updated to KitKat and use the SD card as download location, please go to the settings of this app and reset the download location to SD card.
For Lollipop users: Lock screen widget is no longer supported by Lollipop. Please use the notification on lock screen instead.
PodStore - Podcast Player
Listen, Download, Share the Best Podcast in the World:
- TED Radio Hour
- Welcome to Night Vale
- Radiolab from WNYC
- 60 Minutes - Full Audio
- Android Central
- Stuff You Should Know
- Don't Tell Me! Podcast
- Fresh Air Podcast
- Dan Carlin's Hardcore History
- The Moth Podcast
- Philosophize This!
- This American Life
Import your Itunes Podcast
Subscribe news Podcasts
Download Podcast
Share your favorite Podcast
All this quickly and simply...
Podcast O2
* Cloud refresh: our servers will push updates to your phone and thus save traffic and power. (login required)
* Cloud backup subscriptions (login required)
* Google plus account integration
* Built in variable speed playback: you can set different playback speed for each podcast (Android 4.1+ required)
* Import supported media files (such as audio books) as virtual podcast
* Import itunes subscriptions from OPML file
* Supports streaming and offline playback
* Customizable headset media button actions
* Customizable rewind/fast forward/beginning skip time: global or for each podcast
* Customizable notification buttons
* Automatic download
* iTunes based search
* Sleep Timer
* Auto cleanup
* WiFi filter
* Chromecast support
* Support play video in background
Help translating Podcast O2 to your language:
Join to our Tester community
Application available Language:
Russian (Thanks to Alexander Davydov)
French (Thanks to webster353, mfcourrier, Vincent Brunie)
Dutch (Thanks to derinus)
Portuguese (Thanks to João P. M. Oliveira, Bruno Coelho)
* Your Accounts
This permission lets Podcast O2 provide the option to log in or sign up with Google.
Radio France Podcast
Recherchez vos émissions par radio ou par mot clé.
Abonnez-vous à vos émissions préférées, recevez automatiquement tous les nouveaux épisodes et écoutez les sur votre mobile ou votre tablette.
Accédez ainsi à toute l'actualité en France et dans le monde, à toute la culture et toutes les musiques : chanson française, pop, rock, rap, électro, jazz, musique classique…
L'écoute hors connexion
Pour plus d'infos sur les Nouveaux Médias de Radio France, suivez le blog : http://nvx.radiofrance.fr
BeyondPod for Tablets - Legacy
Full featured Podcast Manager (podcatcher) and RSS feed reader
* DISCOVER thousands of free audio and video shows from all over the world.
* PLAY your content everywhere - either online or offline.
* CUSTOMIZE your playlist to match your listening preferences.
This is a "Lite" version with 7 day full feature trial!
* Sophisticated podcast download engine gives you complete control of how many podcasts to download and how long to keep the old versions. Downloads new content in the background, so you spend more time enjoying your feeds, and less time waiting on them.
* BeyondPod provides full control over what is being downloaded over your data connection. Update a single feed, feeds in a given category, or all feeds. Download a single podcast, the latest podcasts, or all podcasts for a given feed. Nothing happens without your knowledge. Podcast downloads can be scheduled to occur at a specific time, only when connected to WiFi, or only when the phone is charging. BeyondPod also offers an option to automatically (1) Turn WiFi on, (2) Update your feeds, (3) Turn WiFi back off.
* BeyondPod's integrated podcast player support variable playback speed and tracks what podcasts you have listened to. There is also a configurable TiVo style "commercial skip" that lets you easily skip over content that you are not interested in.
* BeyondPod's Smart Playlist automatically generates playlists based on your listening preferences. (For example: First play the 2 newest podcasts of feed A, Then play the oldest podcast of Feed B. etc.). If you follow multiple podcasts Smart Playlist is an excellent way to always listen to what you want.
* BeyondPod's Home Screen Widget gives you one-button access to your podcasts, SmartPlay, and SmartPlay updates directly from your phone's Home screen.
* Integration with Feedly allows you to easily import your Feedly subscriptions. BeyondPod will also synchronize the "Read" and "Starred" status of individual posts so you can read the same feed on both PC or Phone.
* Assign feeds to various categories (such as News, Sports, or Technology) for convenient filtering by topic.
* Use BeyondPod to discover new podcasts and RSS feeds. Search for feeds, import feeds from a variety of popular directories, Feedly, or from external OPML files.
* Import any local files (music, audio books, voice notes etc) and make them playable in BeyondPod audio/video player as if they were podcasts.
* BeyondPod supports Chromecast - cast your audio or video episodes to connected Chromecast devices directly from BeyondPod.
* Use the Sleep feature to automatically turn the podcast playback off after predetermined period of time.
* BeyondPod supports both wired and Bluetooth headsets.
Like to live on the cutting edge? Subscribe to our BETA channel on Google Play! (details at: http://www.beyondpod.mobi/Android/BETA)
uPods - Podcast Player
Forget heavy and expensive applications with a plenty of unuseful features. uPods make all job done for you. Collect your podcasts and listen them with our powerful media player. We are sure that you'll find our playlists more than comfortable.
Maybe you want to transfer podcasts to PC or other device? It's not a problem, we keep it in an ordered way on the phone's disk. Just copy folder with nice sorted podcasts files to needed device. Don't want to download? Our streaming option allow you to listen to all episodes of selected podcast without download any files! Simply select necessary episode and you'll get all podcast feed in your playlist, you don't need search for them in whole app. Just enjoy of auto-generated easy to use playlist!
Need to find some podcast? Try out our iTunes based search!
Access to all iTunes podcasts directly from your Android phone! Just click search button and get fifty most interesting results! Don't know what exactly you search? We brought to you hundreds most popular podcasts built in! Choose category from menu and get access to the best podcasts in the world! Moreover no longer need to check for updates in your Favorites, uPods will do it for you! Simply select update interval and you'll get all last episodes exactly in a time.
* Organize everything
- Simply add your most loved podcasts to Favorites and keep yourself updated with latest episodes of your favorite podcasts.
* Easy, clean and intuitive user interface
- You always know where you are in app, no need to learn something new, just start to use.
* Download podcasts and play it anytime you want
- Download episodes in queue and listen whenever you desire.
* Fully automated cleanup of media files
- Take care of your space on disk, set how many episodes you want to keep, and have app to clean old staff for you.
* Landscape support
- Use app the way want.
* Audio, video, notes and even pdf support
- For those who cares.
* Stream audio over WiFi or cellular network
- Can't wait for downloading, just stream.
* Full tablet support
- If you are an owner of tablet, you will be glad to use our app on your device.
* Playlists based audio player
- Comfortable auto-generated playlists, even if you stream.
* Browse iTunes-like categories
- We designed our application with hundreds best podcasts that are already in.
* iTunes based search
- Search the most biggest iTunes database for staff you need and get fifty the most interesting results.
* Multilingual interface and full RTL support
- uPods translated to English, Russian, Spanish, Hebrew, Korean, Chinese and Arabic. We work hard to make usability of app comfortable for you.
Pocket is your perfect mobile companion for commutes, travel, or curling up on your couch.
★ Webby Award for Best Productivity App and Best User Experience 2014 ★
• Unlimited storage to keep all the articles and videos you save in one place.
• 3 full-screen reading modes for Day and Night.
• Save data with wi-fi only syncing.
• Organize easily with powerful search and tagging.
• Works with your favorite apps and sites like Twitter, Flipboard, Feedly and more.
• Easily share anything from Pocket to Evernote, Twitter, Facebook or a Friend.
• Desktop Browser extensions for Chrome, Safari, Firefox and Internet Explorer lets you save anything from your Desktop to your Phone and Tablet in a one click. Available at http://getpocket.com/welcome
Learn more about us at http://www.getpocket.com/
Questions about requested permissions? See http://getpocket.com/permissions
Flipboard: Your News Magazine
To start, follow a few topics, and Flipboard creates your personal magazine. You can always add more as you find new topics, magazines or interesting people to follow.
Read world class publications like The New York Times, PEOPLE magazine, Fast Company, and Vanity Fair on Flipboard -- find any source with the search bar. You can also connect Facebook, Instagram, Twitter and LinkedIn to Flipboard and easily flip through pictures and posts from friends.
Save stories you enjoy or express a point of view. Use the + button on anything you find to collect it into your own magazine. You can see all your magazines in your Flipboard Profile. For more on how to make your own magazine, visit www.flipboard.com.
Download Flipboard and get started today—it's free!
Plus more great features:
• Collect stories you love into your own magazine. Tap the "+" button on any story, select 'create a magazine' and collect favorite stories, images or videos.
• Manage all your magazines in a convenient dashboard at https://editor.flipboard.com/
• Read The Daily Edition to quickly check the news you need for your day, with stories hand-picked by our editorial staff.
• Go to your Flipboard to check what's happening now. Use the home button on the phone (or Cover Stories on tablets) to see highlights across everything you're following.
• Enjoy Flipboard in 24 localized editions—for Australia, Brazil, Canada, China, France, Germany, Hong Kong, India, Italy, Japan, Korea, Latin America, Malaysia, Netherlands, Philippines, Russia, Singapore, South Africa, Spain, Taiwan, Turkey, U.S., U.K., U.S. Latino.
• On tablets, explore hundreds of staff picks in the Content Guide (tap the red ribbon at the top), including must-read magazines and blogs, gorgeous photography and special curated sections devoted to the news of the day and other interests.
• Use the Flipboard widget for quick access on your Android device.
• Add content from the web to your Flipboard magazines through the bookmarklet at share.flipboard.com.
For tips and other helpful information visit our website http://www.flipboard.com and follow us via @flipboard on Twitter, on Facebook at http://www.facebook.com/flipboard and Google+ at https://plus.google.com/+Flipboard.
To learn more about how to use Flipboard, visit our Support Page. http://flipboard.com/support
If you are having technical issues or have any questions, contact us at http://flip.it/support.
Cast++ Podcast Player
This is a "Lite" version of Cast++ Podcast Player supports up to 3 subscriptions!
Key Features:
* Discover & Subscribe your favorite podcasts in many ways by
- Searching by keywords
- Browsing podcast categories
- Browsing popular podcast list
- Importing podcasts from RSS URL directly
* Integrated Audio/Video Player
- Streams the audio/video episodes over network
- Plays downloaded audio/video episodes
- Shows front cover and notes of the playing episode
- Toggle video episodes to audio
* Instant Refresh Podcast Feeds
Our servers update the podcast feeds in time. Your phone could refresh all podcasts you subscribed in the same time instantly. (Other apps take much time and create huge traffic to update the feeds one by one.)
* Integrated Multitask Download Manager with Powerful Controls
Download more than one podcast audio/video files in the same time by the integrated podcast download manager. You can start, pause and continue the download tasks easily.
Please email us if you have any issues! Thanks for your support.
Cast++ Podcast Player, Enjoy Your Podcasts!
RssDemon News & Podcast Reader
Support all kind of news and blog formats (including not limited to RSS, ATOM, Podcast)
Offers advanced, cutting-edge capabilities, including the most comprehensive podcasting support available today.
Support downloads Podcast for offline playback
Support download full article (mobilize) for offline reading
Add your own news source and choose from predefined feeds and podcasts
Easy Search: You can search for a news source by simple keywords
View article comments/image
Full application Backup / Restore (all settings, feeds and articles)
Highly customizable UI and support multiple theme colors with both dark and light background (
Smart notification to alert user when new article become available
Easy share: Share feed article and news on many sources. Sharing it via Facebook, Twitter and Email is easy (Requires Facebook and Twitter Android app installed)
Easy sorting: User can define Sort Article by Unread/Read First, Date ASC/DESC and Title
User can create news shortcut on desktop
User can choose to use SDCard for cache storage and even move application to sdcard (app2sdcard)
Feed grouping: With feed grouping, user cans easily categorize and locate feed; user can switch between Group View and Flat View
Hide unread: Don't like to see unread feed or article, this option make it easy to navigate
Offline reading: RssDemon download and cache article and image locally for easy offline reading.
Automatic download for new article: User can also choose to download mobilize article and podcast automatically by application for any new article/podcast
Wondercasts Podcast Manager
Chromecast support
Plays audio & video
Streaming and offline playback
Playback controls on: homescreen widget, lock-screen, notification, Android Wear
Sleep timer
Customizable rewind/fast-forward time
Episodes playlist
Remembers each episode's last position
Delete saved episodes after they are played
Automatic podcast update
Downloads queue
Resume downloads when connected to the Internet
Starred episodes
250,000+ podcasts to search
Browse top 100 podcasts over 16 genres*
Add podcast via feed URL
Import and export podcasts via OPML files
Automatically download new episodes
Filter episodes by:
• is it unplayed, started or finished?
• is it audio or video?
• is it saved on device?
• when was it published?
• which podcast is it from?
• is it starred?
*Popular podcasts currently available for Brazil, India, Spain, USA and UK
Cast++ Podcast Player Pro
Powerful podcast player (podcatcher) for Android. Cast++ Podcast Player helps you discover, subscribe, download and play your podcasts.
Key Features:
* Discover & Subscribe your favorite podcasts in many ways by
- Searching by keywords
- Browsing podcast categories
- Browsing popular podcast list
- Importing podcasts from RSS URL directly
* Integrated Audio/Video Player
- Streams the audio/video episodes over network
- Plays downloaded audio/video episodes
- Shows front cover and notes of the playing episode
- Toggle video episodes to audio
* Instant Refresh Podcast Feeds
Our servers update the podcast feeds in time. Your phone could refresh all podcasts you subscribed in the same time instantly. (Other apps take much time and create huge traffic to update the feeds one by one.)
* Integrated Multitask Download Manager with Powerful Controls
Download more than one podcast audio/video files in the same time by the integrated podcast download manager. You can start, pause and continue the download tasks easily.
Please email us if you have any issues! Thanks for your support:)
Cast++ Podcast Player, Enjoy Your Podcasts!
More from developer
Public Radio & Podcast
With home screen widget, your favorite radios/podcasts are just at the tip of your fingers.
This is ads supported app. With in-app purchase ads can be removed. There's no any functionality difference between ads supported and ads free version.
- Live streams from 300+ public radio stations
- Restart the audio play from where it is left before
- Pause/resume audio play on incoming phone
- Ability to skip the beginning part of the podcast
- Set your favorite radio station as alarm
- Sleep mode to turn off radio after scheduled time
- Play in background
- Download and play it any time you want
- Instance search as you type
- Ability to save download to SD card
- Ability to add new radio station manually
- Ability to add new podcast manually
- Home screen widget for easy play control and quick access
- Chromecast support
Note for users with Android KitKat or above:
If you just updated to KitKat and use the SD card as download location, please go to the settings of this app and reset the download location to SD card.
For Lollipop users: Lock screen widget is no longer supported by Lollipop. Please use the notification on lock screen instead.