text:
Meet Cheryl Cheryl Alston, survivor White Plains, MD Cheryl's Story In 2007, I turned 50 years old and my doctor suggested I have a colonoscopy. My doctor referred me, but I "lost" the referral and did not seek another. About two years later, in 2009, my doctor gave me another referral. I "lost" that one as well.… Read More
My Experience with Oral Chemotherapy
by Pam Seijo, advocate & stage IV survivor Back in the early 2000's, after 21 months of chemo, radiation and surgeries, my body was struggling with blood counts, nutrition and overall existence. My oncologist and surgeon wanted me on chemo, but Irinotecan was doing me more harm than good. I had been on it for about… Read More
Generic Xeloda Now Available
Last week, the Food and Drug Administration (FDA) approved the first generic version of Xeloda (capecitabine), an oral chemotherapy pill used to treat metastatic colorectal cancer. Kathleen Uhl, M.D., acting director of the Office of Generic Drugs in the FDA's Center for Drug Evaluation and Research, says "Generic drugs are important options that allow greater access… Read More
Avastin with XELIRI or FOLFIRI: Is There Any Difference?
When Avastin is added to the combination of Xeloda and irinotecan as an initial treatment for advanced colorectal cancer, the treatment is equally effective as Avastin with FOLFIRI. But side effects are more difficult. After a randomized clinical trial comparing Avastin with XELIRI (Xeloda, irinotecan) to Avastin with FOLFIRI (5-FU, leucovorin, irinotecan), researchers concluded that excessive… Read More
Hand-Foot Syndrome Signals Xeloda Effectiveness
Developing tender swelling or rash on their hands and feet may actually be good news for patients being treated with Xeloda® (capecitabine). During a recent clinical trial, colorectal cancer patients with hand-foot syndrome lived longer, and it took longer for their cancer to get worse. Researchers comparing two Xeloda-based chemotherapies for people with advanced colorectal cancer,… Read More
Avastin Helps Patients Maintain Chemotherapy Effectiveness
It doesn't hurt to stop XELOX chemotherapy combined with Avastin after six treatments and continue with Avastin alone until colorectal cancer gets worse, according to a study reported at the 2010 Annual Meeting of the American Society of Clinical Oncology in Chicago. Many patients have to stop oxaliplatin chemotherapy with before getting its maximum effectiveness because… Read More


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March 9, 2012
Chicken Milanese is the perfect Italian recipe to impress your significant other. The term milanese, refers to the dish being prepared in the Milan style- in this case, meat being breaded and fried. Plump chicken breasts are coated in panko (Japanese bread crumbs) and then pan fried until crisp and golden brown. A simple salad of arugula and tomatoes dressed in olive oil and balsamic vinegar tops each breast. The bright flavors of the salad compliment the chicken perfectly. Simple chicken milanese is a dish you'll definitely want to make this Friday.
1 cup of panko bread crumbs
3/4 cup grated Parmesan cheese
3 tablespoons fresh chopped rosemary
2 eggs
6 chicken boneless, skinless breasts
5 tablespoons olive oil
4 tablespoons white wine vinegar
2 cups cherry tomatoes, halved or quartered
In a small bowl, whisk the eggs together
Sprinkle chicken breasts with salt and pepper
Brush both sides of the chicken with egg
Place the chicken breasts in the pan and cook until golden brown, 10-12 minutes per side
Transfer to a platter
Reduce the heat to medium
Add Tbsp olive oil and Vinegar
Cook until hot
Drizzle with vinaigrette and sprinkle with salt and pepper
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text:
Australian Agricultural and Resource Economics Society
1995 Conference (39th), February 14-16, 1995, Perth, Australia
AARES Central Office Manager, Crawford School of Public Policy, ANU, Canberra ACT 0200
Phone: 0409 032 338
Web page: http://www.aares.info/
More information through EDIRC
Phone: 0409 032 338
Web page: http://www.aares.info/
More information through EDIRC
For corrections or technical questions regarding this series, please contact (AgEcon Search)
Series handle: repec:ags:aare95
Citations RSS feed: at CitEc
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by Rygnestad, Hild L. & Fraser, Rob W.
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by Longmire, Jim
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by Harvey, David R.
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by Duncan, Ron
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by Coelli, T. J.
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by Carter, Colin A. & MacLaren, Donald
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by Flores, Nicholas E. & Carson, Richard T.
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by Carson, Richard T. & Flores, Nicholas E. & Martin, Kerry M. & Wright, Jennifer L.
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by Carson, Richard T.
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by Beare, Stephen & Fisher, Brian S.
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by Anderson, Kym
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by Wilson, William W.
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by David, Cristina C. & Huang, Jikun
- 148781 U.S. Agricultural Policy: Implications for International Trade
by Penn, J. B.
- 148779 Games, Clubs and Models: The Economics of Agricultural Economics
by MacAulay, T. G.


text:
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text:
So this limerick is in honor of the giant Australian cuttlefish, who have this very dramatic mating ritual where large males, flashing their chromatophores in fantastic light displays, fight and vie for the attention of females who float coyly by, accepting or rejecting offered sperm packets seemingly on a whim but really with great discretion. She's very choosy about who's sperm she wants to inseminate herself with (shouldn't we all be?).
The small males can't compete with the big bruisers so they have cleverly found a way to get their gametes into the genetic mix by morphing themselves into looking like females (they tuck their cuttlefish junk between their "legs"- just kidding- I can't remember how they do it exactly but you can find out by watching this excellent episode of NOVA called "Kings of Camouflage"). You can view the episode at http://www.pbs.org/wgbh/nova/nature/kings-of-camouflage.html
Here's the limerick!


text:
More About Display Overclocking with Nvidia's GTX Titan GPU
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Registered User
Join Date: Jun 2009
Posts: 56,131
More About Display Overclocking with Nvidia's GTX Titan GPU
The recent announcement of the new top model single-GPU graphics processor GTX Ttian from Nvidia came not only with the expected performance boost, but also with a few new features one of which was the Display Overclocking as a part of the new GPU Boost 2.0. Unfortunately Nvidia did not share much details about the Display Overclocking feature, the first reviews also did not help much in providing us with more details and with the GTX Titan still very hard to obtain, even though it already is on sale it is out of stock pretty much everywhere or is being sold at significantly inflated price where limited quantities may be available, we are still far from finding out what exactly does this feature do and to see how well it worksâ?¦
Display overclocking has become quite popular last year when a Korean company has released IPS-based monitors with driver boards capable of driving the LCD panels at up to 120Hz and sometimes even more, the infamous Catleap Q270 with 2B revision of the electronics. Unfortunately these were in very limited quantities and are hard to find nowadays, even though there is really big interest and demand that is also being fueled by the fact that there are still no stock monitors available that user something different than TN panels and offer refresh rate of 120Hz or up. Unfortunately overclocking these monitors was not an easy task as there are some limits regarding the supported pixel clock rates in the video drivers for both AMD and Nvidia and you had to play with the individual timings of the display with the help of a tool such as PowerStrip or the custom resolution settings of the video drivers. So what we are suspecting that Nvidia has done with the Titan is to just simplify the process, removing the pixel clock limits from the video drivers (no need to patch them anymore) and providing an easy to use interface to overclock the display with the new GTX Titan, but that is yet to be confirmed.
As a part of the latest EVGA Precision X GPU tweak software package there is a tool called EVGA Pixel Clock OC that is supposed to give you this simple solution to overclock the refresh rate of the monitor without having to play with a lot of settings or manually create a custom refresh rate, everything you get is a slider that you can use to adjust the refresh rate and find what is the maximum that your display can work at. As expected this tool does not work on other video cards aside from the GTX Titan, so there is no way to test it yet and see how well it works or if there are any issues using it, but if it works well this can really be a feature that deserves more attention. There are already a lot of gamers going for 120Hz and even the newer 144Hz refresh rate capable 2D/3D monitors and are finding the advantage that these provide for gaming, but with display overclocking you may be able to get some more Hz out of your current LCD monitor as well and that may also improve your gaming experience.
Other similar posts you might be interested in:
Seems that Acer is Preparing a 24-inch 120Hz Full HD Gaming Monitor
Asus VG236H 120Hz 3D-Capable Monitors Appearing on the Market
Playing Blu-ray 3D Movies on a 120Hz 3D-ready LCD Monitor
Playing Blu-ray Movies (non-3D) on a 120Hz 3D-ready LCD Monitor
24â?³ ViewSonic V3D241wm-LED is a 120Hz Display with LED Backlight
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When to Expect a Solution Based on ATI's Open Stereo 3D Initiative
ViewSonic PJD6241 is yet Another 3D-ready DLP Projector
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CMS Instructional Career Fair
- 1430 Alleghany Street, Charlotte, NC, 28208
Social Media 101: A Branding Perspective
Roxy Digital Group
Saturday, January 12, 2013 from 10:00 AM to 12:00 PM (PST)
Do you own a small or mid-sized business? Does the thought of maintaining a Facebook or Twitter page stress you out? Do you know what to blog about on behalf of your brand? Do you have a blog? Do you know what a blog IS? Overwhelmed? Don't be! You've come to the right place!
I will be leading a Social Media 101 For Businesses "Boot Camp" on Saturday, January 12 for small business owners and individuals alike looking to break into the social media realm. I will show my class firsthand why social media is important for growing a business, how it can help with seeing your return on investment, and give you the tools to position your brand as a thought leader in your industry.
We will be using Facebook and Twitter as the two leading social media networks to examine and understand. Each social network will be covered in this class, specifically relating to understanding features and leveraging this knowledge with building an audience and a following. The final portion of the class will cover the "How To's" of blogging and why a blog may be a good idea to launch from a branding perspective.
Hope to see you on the 12th!
Roxy Digital Group is a digital boutique specializing in social media marketing. We aim to provide our clients with top-level social media, blogging and design services. Whether you are a start-up business or an individual looking for social media help, we cater to any and every industry both U.S. based and internationally.
Our a la carte packages are tailored specifically to the needs of your business in order to ensure you achieve your dreams of social success.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


text:
I'm having a problem creating new subdomain subsites.
I create the site through Network Admin, it appears in the site list, the email goes out and the DB tables are created. However, when I try to access subdomain.domain1.com or /wp-admin/ I get an error saying "Could not find subdomain.domain1.com".
I currently have 3 add-on domain subsites running without problems.
So I'm not sure if it's a problem creating new subsites in general, or something specific to subdomain subsites. They worked in the past, so it shouldn't be the DNS wildcard, htaccess looks fine and I've confirmed with my host that AllowOverrides is enabled.
Any ideas?


text:
Stock Vector Illustration:
A man playing fair strength test game high-striker with success
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- Copyright: stoonn
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text:
10hr's 55rbi's, plate discpline is coming around, if he finishes the season strong his first should be forgotten.
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10hr's 55rbi's, plate discpline is coming around, if he finishes the season strong his first should be forgotten.
Originally Posted by New Fever
i would like to see him at AAA somtime next season. he has alot of upside and could be the reds starting first baseman in the next 3 seasons.
I hope he does well, but I would like to see Dunn as the everyday 1st baseman for the next 10 years.Quote:
Originally Posted by toledodan
i just have the gut feeling that kearns is down at AAA to play everyday untill they trade dunn. i believe if that happens the front office will keep casey around long enough untill votto is ready.Quote:
Originally Posted by Jpup
Well.... he's not coming on real strong. One week ago he was also hitting .260, so he's just holding his own (as opposed to Perez who raised his average 15 points in the same time frame)
But he did homer twice in that period, so it will be interesting to see if that is a trend. He hit 19 last year, so it seems both his average and power numbers will be down for the season unless he really goes crazy.
There is no way Votto will START in AAA next year. There is a 1b vaccum at AA so he'll start there next year. He really needs to step it up if he is going to be the Reds 1b of the future.
I agree that Votto's got to do A LOT better if he's going to be a viable option at 1B in a few years.Quote:
Originally Posted by JaxRed
Though you're batting average fascination remains a bafflement. Who cares if Miguel Perez raised his BA 15 points? Sure, it's better than nothing, but he's still a Judy hitter with no eye. It's the difference between largely worthless at the plate and completely worthless at the place (which is where Perez will head back to when he cools off).
A batting average bump for Votto obviously would net more significant returns, but he's still only got a .246 secondary average, which is way down for him. He's struggling across the board.
i thought votto should have started in AA this season, but i hope he finishes strong, and puts together some good overall numbers.
Votto kind of reminds me of Broussard. I hope I'm wrong. Broussard isn't terrible though.
He's starting to remind me of Bender too - running hot and cold in the minors, power that's all right but never seems to take that big leap forward. Though, to be fair, Votto's only 21 and his power might be two or three years off.Quote:
Originally Posted by redsandrails
Yeah..... Broussard was a lot older. He was in AA when he should have been in AAA or majors IIRC.
i wanted to bump this up again. is there any chance we might see votto up here this season?
Not unless he really explodes in AA and AAA.
Our season would really have to be in dumps. But I don't believe so, really took a step back last season.
Take a look at the off years Austin Kearns and Kal Daniels had in single A when they were coming up. I'm hoping it was a similar detour for Votto. All signs had been pointing to the kid being good.
lollipop, interesting use of Austin Kearns and Kal Daniels in the same sentence.


text:
Zagat 2009: Per Se, Ko, Asiate, USC Emerge Victorious
Less New Yorkers are dining out, but those still eating have spoken via the annual Zagat guide.
Less New Yorkers are dining out, but those still eating have spoken via the annual Zagat guide.
The real tragedy of Ko's reservation system is when there are several empty seats going to waste.
What the other critics are saying in our weekly roundup of restaurant reviews.
You'll also need $160 and three hours.
Metromix remembers what we were all so excited about in 2007.
A yummy BYOB Mexican cantina in Williamsburg, and a tribute to Bemelman's Bar, in today's neighborhood food news.
Don't think lunch will be any cheaper or easier to get into.
Now that he has called off the fight against Bowery Wine Bar, we have some suggestions for a new bogeyman.
Food critic Ramond Sokolov is skeptical about chef's counters.
Facing the truth about Ssäm.
"I wanted to do something where I'm doing the cooking."
They came, they saw, they blogged.
Plus: Salmonella victims in Nassau County, learning knife skills from a book, and more, in our morning news roundup.
There were plenty of empty seats at Ko last night.
Should auctions be a regular thing?
David Chang's quixotic quest to ban cameras at Ko is earning its own wave of bloggy controversy.
One sign read BAN BELLINI, SAY YUCK TO YUPPIES.
Plus: Gourmet eats at the ballpark, Marco Pierre White's dress-code faux pas, salmonella-tainted tomatoes, and more in our morning digest of news and gossip.
The saga of the Momofuku Ko-thario — the man who used Craigslist to leverage his extra seat at Ko into a date with Dominique of Dominique Eats Out — has come to an end
According to one of his potential Ko dates, he's "funny, charming, lots in common, cute. Looks like a tall dark Jewish Michael Cera."


text:
Local churches held remembrance services Sunday.
A project, years in the making, is finally breaking ground Friday.
Centre County Commissioners decided to withdraw county-provided cell phone service for state employees, more specifically, members of the judiciary.
The fight between top Centre County officials continued in court Wednesday, this time between the District Attorney and County Commissioners.
Could changes be on the horizon for some county employees in our region? Why one commissioner is pushing for updated rules.
CentrePeace has operated out of a small building on the Benner Pike since 1994, but now it's moving to a bigger and better facility, something its executive members hope will benefit the community in more ways than one.
May is National Foster Care Month and Tuesday in Centre County, dozens of people gathered on the steps of the county courthouse to celebrate.
It was around 5:00 Thursday that Spring Township Police in Centre County said a man attempted to abduct a teenager while he was out for a jog.
Law enforcement agencies in Central PA are working to keep their relationships positive in our communities, especially with kids.
Downtown Bellefonte is back to normal Tuesday night after several streets there were shut down for a couple of hours while police and bomb squad techs checked out a reported suspicious device.
Several state representatives are meeting with local business owners across Central PA to gauge their stance on the state's business and job climate.
The Mount Nittany Health Children's Advocacy Center has served hundreds of children in just over a year and not just in Centre County. Officials there said they help kids from all across Central PA.
It was ten years ago Wednesday, then- Centre County District Attorney Ray Gricar was reported missing.
Centre County Commissioners are reacting Tuesday to the appointment of a new Assistant District Attorney.
The lack of sprinkler systems in some of Bellefonte's historic buildings has been a long standing issue. Now, local fire companies are hoping to change that thanks to a new grant.
It's the first time some Centre County judges, commissioners, the district attorney and other elected officials are squaring off in court.
Centre County officials voted to approve a three year contract between the county and an independent service agency to help fill a vacant financial operations position in the county's mental health services program.
Two Centre County judges have filed suit against the county and some local attorney offices, leaving some county leaders confused and upset.
Jeffrey Buck Jr.'s untimely death is weighing heavily on the hearts of thousands across the nation. Now, more local firefighters are trying to step in to help his family.
A Centre County judge and the district attorney are under fire again, this time over text messages they allegedly sent during a rape trial in 2014.
It's a tool police departments across the nation use to help them solve cases or determine a suspect's guilt or innocence.
Law enforcement officers and emergency first responders from across the state gathered to pay their respects to a fallen officer Friday.
The fight between the Paterno Estate, the NCAA and Penn State continued Friday in Centre County court.
Snow and ice made for dangerous road conditions Monday morning in Centre County.
We're learning new details Wednesday in the investigation of Centre County District Attorney Stacy Parks Miller.
Allegations of criminal activity by the Centre County District Attorney were brought to light in front of Centre County Commissioners Tuesday.
A group of protestors in Centre County said they want to protest government corruption, statewide and locally.
It's a topic of discussion for many areas in our region now - to increase vehicle registration fees or not.
A Centre County man already facing more than 300 sexual assault and rape charges is now facing even more.
Do you recognize the man in the gray hooded sweatshirt in this newly released surveillance video?
2015 is the year for major construction projects in Bellefonte, but borough officials are starting to weigh concerns about how the construction will affect parking.
A Centre County woman is behind bars Tuesday after police said she abused at least two of her kids.
A town in Centre County changed its holiday decorations this year to honor a man who had a long tradition of spreading Christmas cheer.
The holiday season is upon us, which means more shopping and more shipping. Now, police are warning folks about mail theft.
A local courthouse is looking for a way to help you give back to the community.
An international vigil is being held Friday for an American pastor jailed overseas.
A business destroyed by fire in 2012 is reopening its doors, nearly two years later.
What are the biggest problems facing Centre County? The Chamber of Business and Industry of Centre County hosted the first annual "State of the County" luncheon Tuesday.
According to the study, children whose families eat dinner together four or more times per week have fewer problems with cyberbullying than those children who never have family dinners.
A 911 communication tower in Centre County is at the center of debate between county commissioners and the land owner.
As the number of prisoners in need of mental health assistance grows, so are concerns about how to afford that increasing care.
Josh Hardy still has a long road to recovery, but his family is hoping to help by giving back to the community.
The Bellefonte Youth Center is one step closer to opening its new doors.
Local businesses are participating in a weekend giveaway to help students in our region prepare for back to school.
A local town is looking for a big economic boost and they're hoping a new microdistillery may be the ticket.
The salaries for elected officials in Centre County are one step closer to being decided by county commissioners and this year, they're planning to make some changes.
A Centre County food bank is expanding and they're getting some help along the way.
A local high school music teacher is nominated for a national award, thanks to one of his students.
A Bellefonte man plea guilty to four counts of robbery.
A prison case in Centre County sparked a state and system-wide overhaul of prison security.


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Originally written on Fox Sports South | Last updated 11/28/12
CORAL GABLES, Fla. -- Senior Trey McKinney Jones scored a career-high 18 points and the Miami Hurricanes beat No. 13 Michigan State 67-59 on Wednesday night. McKinney Jones went 5 for 7 from 3-point range, including a basket that capped a 14-2 run to start the second half that put them ahead 41-33. The lead grew to 57-45, and the Hurricanes went 8 for 8 from the free throw line over the final 2:11 to seal the victory. Miami (4-1) held the ball in the final seconds to run out the clock, and students then stormed the court, hoisting at least one player and the team mascot onto their shoulders and chanting, "ACC." The game was part of the ACC-Big Ten Challenge. The Spartans (5-2) lost for the first time since the season opener against Connecticut.
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Osmond DH, Bindman AB, Vranizan K, Lehman JS, Hecht FM, Keane D, Reingold A. 1999. Name-based surveillance and public health interventions for persons with HIV infection. Multistate Evaluation of Surveillance for HIV Study Group. Annals of Internal Medicine 131(10):775–9.
Pagano M, Tu X, De Gruttola V, MaWhinney S. 1994. Regression analysis of censored and truncated data: Estimating reporting-delay distributions and AIDS incidence from surveillance data. Biometrics 50:1203–14.
Payne SM, Seage GR 3rd, Oddleifson S, Gallagher K, vanBeuzekom M, Losina H, Hertz T. 1995 Using administratively collected hospital discharge data for AIDS surveillance. Annals of Epidemiology 5(5):337–46.
Rosenblum L, Buehler JW, Morgan MW, Costa S, Hidalgo J, Holmes R, Lieb L, Shields A, Whyte BM. 1992. The completeness of AIDS case reporting, 1988: A multisite collaborative surveillance project. American Journal of Public Health 82(11):1495–99.
Scheer S, McQuitty M, Denning P, Hormel L, Stephens B, Katz M, Schwarcz S. 2001. Undiagnosed and unreported AIDS deaths: Results from the San Francisco medical examiner. Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology 27(5):467–71.
Schwarcz SK, Hsu LC, Parisi MK, Katz MH. 1999. The impact of the 1993 AIDS case definition on the completeness and timeliness of AIDS surveillance. AIDS 13(9):1109–14.
Schwarcz S, Hsu L, Chu PL, Parisi MK, Bangsberg D, Hurley L, Pearlman J, Marsh K, Katz M. 2002. Evaluation of a non-name-based HIV reporting system in San Francisco. Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology 29(5):504–10.
Solomon L, Flynn C, Eldred L, Caldeira E, Wasserman MP, Benjamin G. 1999. Evaluation of a statewide non-name–based HIV surveillance system. Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology 22(3):272–9.
U.S. Congress, House of Representatives. Committee on Commerce. 2000a. Report on Ryan White CARE Act Amendments of 2000 (106-788). 106th Cong., 2d Sess. July 25, 2000.
U.S. Congress, Senate. 2000b. Committee on Health, Education, Labor, and Pensions. Report on Ryan White CARE Act Amendments of 2000 (106-294). 106th Cong., 2d Sess. May 15, 2000.
Verghese A, Berk SL, Sarubbi F. 1989. Urbs in rure: Human immunodeficiency virus infection in rural Tennessee. The Journal of Infectious Diseases 160(6):1051–5.
Verghese A, Nabhan D, Escobedo MA, Guardado J, Guerra LG, Ho H, Casner P, Berk ML. 1995. Profile of HIV disease in an American border city. Southern Medical Journal 88(4):429–32.


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"Odd but Interesting"
The story was enjoyable but not as exciting as the other Odd Thomas books.
The Eye of the Dragon - Stephen King
Not my favorite of the series
"One of the worst books EVER...."
Seriously considering giving up Dean Koontz for this atrocity that has been inflicted upon the world.
Stupid,stupid, stupid.... Why mess with an awesome character that can see ghosts that cannot talk by adding hokey time travel and mutant pigs from the future!!!! Boring for the entire first half of the book. And the second half, i waited to see how bad it got and was rewarded. Anna Marie character was useless and ignored completey by Odd and all the evil for the 95% of the book. Absurd!
Vincent Price
Absolutely, positively not one redeeming quality. If you skip this book and go straight to the next you won't have missed a thing or be lost.
Absolutely hated it. What a waste of a wonderful character.....
"Koontz could have done this in 4 chapters"
Virtually the whole book consists of Odd Thomas wandering from place to place on an estate and discussing his philosophy of life, with a little action mixed in. I have enjoyed the previous Odd Thomas books, but this one is lacking. The reader did what he could with the material, but this one was a job to finish.
"first book thru audible.com"
It was so easy to use the Kindle to listen to this book. I love my Kindle.
"A Bit of a Departure but still an Awesome Read!"
The only reason that I gave an overall rating of 4 is because this book, the setting/place, greatly departs from the previous books... I don't say it departs is a bad way, but I'm still thinking it over. Having said that, I'd readily purchase the book again!
If you're an Odd fan - Buy it, read it. Odd is considerably more 'no-nonsense/ruthless' in this novel - which is good to see.
Dean appears to be taking Odd to a new level and it appears from this book that all bets are off as to what that direction could be.
Great job Mr. Koontz, can't wait for the next one!
"Odd Again"
The point where Odd realizes what is going on
The last scene because I know there will be another.
No, but I eally enjoyed the book as I have all of the Odd books, I cant wait for the next one, please hurry Dean.
Excelent book the Odd Thomas book are my favorite Koontz books and I am propetualy waiting for the next Odd adventures. I found myself disapointed at the end not because of the story but because it was over, and I so wanted to continue on with Odd's story.
I know the author shouold always leave us wanting more but I would have no problem listening to 30 or even 40hrs of an Odd story.
"Odd is Odd"
Odd is a bit hard to believe - lucky this is fiction. Okay the story gets way crazy early and stays there. I feel that the pinnacle of this series was Brother Odd. Oh well.
"Odd Marches on"
This book advances the adventures of our hero seamlessly. The skewed view of the everyday world this beloved, self effacing "fry cook" never ceases to crack me up. This is wry, high entertainment.
Odd Thomas is always my favorite character, but the elegantly named time traveling exterminator is a strong second.
I love Mr. Bakers gentle narration and he has become the voice of Odd Thomas to me. If I were to "read" the books, I would hear his voice in my head.
I am so delighted when a new Odd adventure appears, more so than any other fiction hero I can name. Bravo, and keep em' coming.
"An Odd story"
I have listened to all the Odd Thomas books, this one was my least favorite.
i saved a drab colored lizard who thrashed desperately in your makeshift bird bath this morning, around eight. he was beneath your notice.
"2nd tier"
This wasn't the best in the Odd Thomas series. 'Odd Thomas' and 'Brother Odd' reach the "rollicking good story" level, and the others fall off to an enjoyable, but not quite as engaging 2nd tier. Still, this was better than a sharp stick in the eye, or a dull knee to the groin, or a ham fist to the gut, or an angry badger down the shorts, or a collect call from your daughter from jail, or finding out the promotion went to that jerk-wad, or getting run over by a steamroller, or being blackmailed by that treacherous little weasel, or losing your super powers, or reading through a pointlessly long sentence in a review. Maybe not that last one, but you get the idea.


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Christmas has come and gone, New year has come and gone, however the bad feelings have gone and come back. I was generally very happy for the majority of the holiday, but a few days ago I got really down again. I decided I have had enough with all of this shit, I need to get something done, so I went back to the doctors. I went to the doctors about a month ago and was given a questionnaire, I filled out the questionnaire and after googling it I discovered that if your total isn't over a certain number your deemed as ok but with some issues. I stupidly didn't go back and show the doctor the result because I had to much faith in my google result.
With the idea that I was fine I drilled that into my head, I forced smiles on my face when I really didn't want to because I was "Fine". The weeks went passed and some part of my believed it, but the more time passes by the more times I have to convince myself I'm fine. So last night I decided that if I need to constantly remind myself that I'm fine then I clearly must be not fine. I wrote down all i thought was wrong with me and went back.
I was sat in the waiting room for about half an hour, which sucks because I hate waiting in the doctors, its there no phone on policy that sucks. I asked to see a female doctor this time, I work with females and most of my company is from females so I just wanted a doctor who I would feel more comfortable with. When I went in I explained that I never came back, the doctor then told me that that answer to the questionnaire is a vague guide instead of a clear yes or no. Me and the doctor talked for the full 10 minutes going through my situation, much better than my previous doctor who handed me the questionnaire and told me to come back in a few weeks.
The doctor told me then told me that I may not be depressed, but there is something wrong. She told me that I am more likely suffering from an anxiety disorder than depression, which surprised me but when she told me why I kind of agreed. So for the next 2 weeks I am to keep a mood diary, each day I am to give a rating to the day out of 10 in terms of my mood, write about something that I found difficult and something that I enjoyed.
Thank you for your kind Christmas messages duders, it's nice to know that although I am hated by many I am appreciated by few.
Oh and to give this something for the game people, I started getting into XCOM, I'm playing on easy but fuck it I play games to enjoy them not to get frustrated!


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Pretty Little Liars
Pretty Little Liars Stars Share Their Own "A" Theories (VIDEO)
We've done our fair share of guessing who "A" is, but what about the Pretty Little Liars cast? Who did they suspect the most before ultimately finding out in the final script?
In this featurette, a few of the key players offer their opinions on what they would do if they found out they were "A," and who they really think shim is (again, this was shot before any of them found out for real).
Lucy Hale (Aria) had already heard some "Ezra is 'A'" rumors, which she called "funny." Ian Harding (Ezra) says he "would love that." Another popular suspect, Melissa Hastings (Torrey DeVitto), was Ashley Benson's (Hanna) pick. And Drew Van Acker (Jason) says that he thinks Jason "has more of a heart to do some of these things." Really?
Watch the video to see all of the above, plus the opinions held by Keegan Allen (Toby), Tyler Blackburn (Caleb), and Shay Mitchell (Emily).
Find out who "A" is on the Pretty Little Liars Season 2 finale on Monday at 8 pm ET/PT on ABC Family.
Source: ABC Family
Want more Pretty Little Liars? Like us on Facebook and Follow us on Twitter and Tumblr.


text:
Artscape Trailer: Light from the Shadows, screens 10pm Tues. 9 July on ABC1
Danny Eastwood is an influential and groundbreaking Australian Indigenous artist who has been working in the Blacktown community for over 30 years. At 68 years old he has retired 3 times -- but unable to say no, Danny finds himself continuing at a tireless pace teaching art classes throughout his community with inmates, Elders and school kids.
Danny is a prolific and diverse artist practicing as a cartoonist, illustrator, and painter. He is also a very modest man who has won the Parliament of New South Wales Indigenous Art Prize in 2008 for his entry 'My Reconciliation', a pen, ink and watercolour on paper, depicting a scene from the back lane he grew up in as a small boy in inner Sydney.
Each fortnight Danny has to complete a cartoon for The Koori Mail -- something he's been doing for the last 20 years. In between these deadlines he travels across Mt Druitt and Sydney teaching art to inmates from Long Bay jail, Elders, school kids and community groups, as well as working on new public art works
Light Into the Shadows gives us an intimate and informative insight into Danny, his politics and life. The documentary includes interviews with Kirstie Parker -- Managing Editor of the Koori Mail, Pam Eastwood, Danny's wife, and academic Prof. Larissa Behrendt.
Artscape presents Light from the Shadows on Tuesday 9 July at 10pm on ABC1 as part of the ABC's NAIDOC week programming.
Written & directed by John Harvey, Produced by Tom Zubrycki. Commissioning Editor: Dena Curtis, ABC TV Indigenous Department.
Find out more
Read >> Find out more about NAIDOC week coverage and events on the ABC Indigenous Gateway.
Comments (2)
Kate Dempsey :
11 Jan 2014 10:06:52am
I would like to try and find a copy of the full show, for reference in a university project. Is there a url I can access it from? Or somewhere I can download a copy?
Rob :
09 Jul 2013 10:36:32pm
Just went to the online Koori Mail. I would have loved to be able to flick through the cartoons. I cant find a way to email @ http://www.aiatsis.gov.au/koorimail/index.html Is there any way to go see the originals individually?
Moderator: Hi Rob,
The contact details for th Koori Mail are listed here: http://www.koorimail.com/about-koori-mail/contact-us/
And Danny Eastwood's illustrations are regularly added this this page: http://www.koorimail.com/news/danny-eastwoods-view/
Hope this helps.
- ABC Arts


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The eurozone crisis
The ongoing eurozone crisis has enormous implications for Britain. Plunging GDP predictions across the continent have a strong effect on our own economic performance, of course. But David Cameron's veto of a bid to push through fiscal integration across the European Union has prompted fresh tensions of its own, as Britain's relationship with the continent is fundamentally reassessed.
Comment: The British left shouldn't put too much faith in Syriza
Strip away the rhetoric and Tsipras and Varoufakis have a surprisingly conservative programme
Comment: Greece gives EU the chance to rediscover its social mission
Europe wasn't just a free market project - it was about solidarity. Now it's time to show it.
Why doesn't Miliband talk about Europe like this?
Sir John Major has painted a striking picture of an irrelevant, smaller Britain outside the European Union. Why doesn't Miliband talk about Europe like this?
A slap in the face: EU hits Cameron with shock £1.7bn bill
Out of nowhere the European Union has produced an eye-watering demand for £1.7 billion, payable on December 1st please. It's a minor catastrophe for David Cameron.
Dividing lines: Tories to reintroduce EU referendum bill
Conservatives stand ready to "foil" the Liberal Democrats over the EU referendum bill, the backbencher championing the legislation has said.
Tory MPs admire Cameron's laurels of defeat
Make your choice: David Cameron is either a feckless idiot or a principled champion of Britain.
Sun trumps politics: Majority of Brits 'would leave UK'
Over half of Brits would emigrate to another European Union country if they could guarantee their standard of living would not fall, a poll has found.
Tories accused of working with extremists in Europe
David Cameron hammered the "final nail in the coffin" of the Tory modernisation project by agreeing to work with far-right parties in Europe, Labour says
Opinion Former News
ABI International Regulation Seminar
Collision or Convergence? A New World Order for the International Insurance Market? The collapse or forced bail-outs of a series of large, financial institutions in 2008 threw both markets and governments into turmoil. Now the fate of some European economies threatens even larger ructions.
CPA: Eurozone Slowdown and Cost Inflation Pose Major Threat to Construction Product Industry
The Construction Products Association's latest State of Trade Survey, which has been launched today, shows that although a Eurozone crisis appears to have been averted for the time being, the prospect of an economic slowdown in the major European economies, together with increasing global energy and raw material prices, remain as the major threats to further recovery in the UK construction products industry.
Skills crisis
RAeS Careers & Education Manager Rosalind Azouzi analyses a UK report which forecasts a shortfall between the demand for future engineers and the supply of suitable candidates.
Insurers must be in a position to help Europe fight back to growth, say ABI
Regulation must help drive growth not hinder it, the Association of British Insurers said today at a conference to discuss the new pan European set of rules, Solvency II.
Everything you need to know about the eurozone deal in five minutes
What is the eurozone deal, what does it mean for British politics and will it solve the crisis?
Cameron's EU veto statement as-it-happened
Every twist and turn of a dramatic afternoon
Comment: Greece deserves a better empire than the eurozone
They'd be better run by the Disney themepark division
Podcast: Eurocrisis and eurosceptics
Growing divisions within the eurosceptic rebel camp
Britain urged to 'unilaterally declare independence' from Europe
Britain can make a "unilateral declaration of independence" from the EU by giving British courts legal primacy, an influential think tank suggests
Clegg/Farage debate: The case for the EU is dead
Supporters of the EU won't argue for it - they only dare argue against leaving it.
The Political Week Online: Farage wins TV debate
Nigel Farage is declared the winner of #NickvNigel - but what is #FarageFacts? Marriage equality legislation comes into force. And is Ed Miliband weird?
The importance of being idle: Why Ukip's MEPs should trumpet their laziness
Attacking Nigel Farage and his party's MEPs for laziness in Strasbourg risks backfiring
Merkel speech verdict: A cut-and-paste EU defence destined to be instantly forgotten
The German chancellor fails to live up to the occasion with a pedestrian defence of the EU.
The Political Week Online: Blair witch project (sorry)
Blair, Brooks, bishops, benefits, Clegg vs Farage, and Richard Littlejohn.
EU referendum bill's agonisingly slow death continues in the Lords
Tory bid to secure an EU referendum faces an impossibly tough test in the Lords
'Right wing nationalist escapism': Clarke comes out swinging against Cameron's EU migration rhetoric
Ken Clarke hits out hard at the bellicose anti-immigrant rhetoric coming out of Downing Street, with a description of concerns about EU freedom of movement as "typical right wing, nationalist escapism"
Eurosceptic Tories raise stakes with EU veto demand
Over 100 Conservative MPs have called on David Cameron to effectively declare war on EU diplomats - by backing a new law which would give Britain a veto over all new EU legislation.
The stolen referendum: European court 'robs Britain of vote' by overturning UK opt-out
A European court's ruling effectively overturning Britain's opt-out to the charter on fundamental rights has robbed the UK of a referendum, Tory MPs are claiming.
The Political Week Online: Conservatives, cows, and Christmas
The House of Commons debates bringing forward the proposed EU in-out referendum. The Taxpayers' Alliance debates replacing them all with chickens to cut costs. (Okay we made that up.)
Tory EU referendum car crash as-it-happens
Live coverage of Labour troublemaking over the Tory EU private member's bill, with an added sprinkle of Tory infighting.


text:
UKC Gear – The Depot Climbing Centre Search Gear
Announcements direct from The Depot Climbing Centre
The Depot Climbing Centre News
The Battle of Britain is back at the Depot Leeds for 2014. On Sunday 12th October some of the best boulderers in the country will... Read more
The Depot Nottingham is looking for a part-time staff member who is available to start work from Mid July.
Roles will... Read more
Up to 70% off, The Depot Shop's biggest clearance on selected brands.Clothing, shoes and accessories all reduced whilst stocks... Read more
The Battle of Britain is back for it's 4th year. This years competition will be at The Depot Nottingham. With �500 up for grabs... Read more
The Battle of Britain is an annual competition held at The Depot. It is the biggest competition held at the centre. The Prize... Read more
The Depot in Leeds is proud to announce the Battle Of Britain bouldering competition 2010.Full day competition for all abilities... Read more
On Friday the 26th of March the Depot is holding the final of Leeds Bouldering League 2009/10 as well as celebrating the Depot's... Read more
On 11th of September we will be opening Phase 2 of the Depot with a fun bouldering competition and an opening party at the award... Read more
All The Depot Climbing Centre by date
- The Battle of Britain 2014 Oct-14
- Job Vacancy at The Depot Nottingham Jun-14
- The Depot Clearance - up to 70% off selected brands May-14
- The Battle Of Britain bouldering competition at The Depot in Lee Nov-10
- Boulder Leeds Final This Friday At The Depot Mar-10


text:
Member since Mar 2013
2 Curated Comments,
2 Total
I agree completely that the Travel Time Budget is unlikely to be altered much by driverless cars. Marginal increases …
Another excellent addition to an outstanding series.
One argument carried through many of these articles deserves more scrutiny: the notion that …


text:
- Shopping Bag ( 0 items )
P. J. O'RourkeAs a key to the secret of Starbucks, Starbucked is a failure—a failure that we should all buy and read. Because in Part 2 of his opus, Clark turns from trying to explain why Starbucks is successful to trying to judge whether Starbucks is a monster of capitalist rapine. And we are treated to astonishing examples of open-minded intellectual honesty, arguments from evidence and cleareyed reporting.
—The New York Times


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This is the most comprehensive range of building materials and building products supplies in Australia. Whether your project is large or small – or require construction equipment, maintenance or management - the links below have everything you need. Everything from architecture and building construction to the final touches on lighting, flooring and decking, doors and door hardware. Available building products range from wall building material, guttering, water tanks or ceilings for building construction to adhesives and sealants, bathroom fittings, windows and glass, paints and finishes to complete the job. ProjectLink makes it easy to build from the ground up!
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Train passengers who will be attending events at the new Perth Stadium in Burswood have been given a first look at what the future Stadium Station will deliver.
THE passage of the Airports Amendment Bill 2015 through parliament overnight brings an airport for Western Sydney another step closer.
Key areas including health, infrastructure, jobs, housing and education have received a boost in the NSW 2015-16 Budget.
The Government has delivered the 2015-16 NSW Budget for regional NSW.
Western Sydney hospitals are set to receive an extra $100 million in funds for upgrades as part of the hospital rebuilding program underway across NSW.
CONSULTATION has started on a $100 million investment in the redevelopment of the Hobart International Airport, which includes a $38 million commitment from the Australian Government.
Major infrastructure projects across western Sydney are on-track to boost the economy and provide the region with quicker travel times for commuters.
The State Government will establish a new city high school next to the current Royal Adelaide Hospital, catering for 1000 students and opened for the beginning of Term 1, 2019.
Regional Development Minister Terry Redman announced 86 projects across the State's nine regions would benefit from the 2014-15 round of the State Government's Regional Grants Scheme, funded with $9.024 million from the Royalties for Regions program.
Ellenbrook was recognised as the world's best master-planned community at an international awards ceremony in Kuala Lumpur.
The Andrews Labor Government is getting on with the job of upgrading Rod Laver Arena to ensure the Melbourne icon retains its status as one of the world's leading sports and entertainment venues.
AUSTRALIA's prehistoric past will come alive in the future with the completion of stages one and two of the Australian Age of Dinosaurs Museum upgrade in Winton.
A new $400 million waterfront community is a step closer after the Queensland Government announced it will work exclusively with Leighton Properties to finalise a detailed proposal to design and build apartment, retail and commercial buildings.
A new Palaszczuk Government infrastructure bonanza will pump $200 million over the next two years into regional projects, supporting about 600 jobs across the state.
Enhanced directional and interpretive signage made from recycled plastic has been added to the 'Junction Walking Trail' in Casterton, South West Victoria.
An alternative to traditional, static power points, Eubiq's innovative power track allows you to add, remove and reposition power outlets, anytime and anywhere. With Eubiq you can get power at the point that suits you.
Capital Safety, the global leader in fall protection has announced the launch of their new DBI-SALA® range of Python Safety® Fall Protection for Tools,a collection of dropped object prevention solutions for tools and equipment.
A range of surface, flexi, track and pendant LEDs to suit any application.
The indoor air quality detector (IAQ) is a simple, low-cost and low-maintenance CO2 + VOC transmitter based on modern bio-semi-conductor technology.
Using SpiraPave very low height pedestals under decking tiles, provides a new appealing surface without the need for a major roof renovation and still maintaining access to drainage outlets for routine maintenance.
When developing a master plan for Port Mac Donnell, the District Council of Grant, in South Australia, wanted to find some outdoor furniture that would meet the brief of a coastal township.


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Posted October 16, 2012 and updated on October 16, 2012
Why is A League Of Their Own rated PG?
Official MPAA Rating: A League Of Their Own is rated PG for for language
Please read our content details for this movie to help determine if it is suitable for members of your family. We also encourage you to check our full review and our movie information page.


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Are you Phyllis LuValle?Claim your profile
Publications (29)136.24 Total impact
Article: Activating transcription factor 2 targets c-Fos, but not c-Jun, in growth plate chondrocytes[Show abstract] [Hide abstract]
ABSTRACT: Activating transcription factor 2 (ATF-2), c-Fos, and c-Jun belong to the bZIP family of transcription factors. Promoters of c-Fos, c-Jun, cyclin D1, and cyclin A are targets of ATF-2 in primary mouse chondrocytes. An ATF-2 expression vector was co-transfected with either c-Fos or c-Jun promoters in mutant ATF-2 chondrocytes in order to show by luciferase assay that ATF-2 increased promoter activity of c-Fos, but not c-Jun. Chromatin immunoprecipitation (ChIP) assays revealed that ATF-2 bound with the c-Fos promoter at the -294 cyclic AMP response element (CRE) site, but did not bind to the TPA responsive element (TRE) or activating protein-1 (AP1) sites of the c-Jun promoter. Dominant-negative (dn) c-Fos inhibited cyclin D1 promoter activity. However, dn c-Jun had minimal effect on this same promoter activity. c-Fos was capable of interactions with both the cyclin D1 CRE and AP1 sites, while c-Jun co-operated specifically with the cyclin D1 CRE site. Neither c-Fos nor c-Jun had any effect on cyclin A promoter activity. c-Fos was unable to bind to the cyclin A AP1 or CRE sites. In contrast c-Jun was competent in interactions with cyclin A AP1-2 as well as the CRE.Journal of Cellular Biochemistry 01/2011; 112(1):211-6. DOI:10.1002/jcb.22925 · 3.37 Impact Factor
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ABSTRACT: Lamin A (LaA) is a component of the nuclear lamina, an intermediate filament meshwork that underlies the inner nuclear membrane (INM) of the nuclear envelope (NE). Newly synthesized prelamin A (PreA) undergoes extensive processing involving C-terminal farnesylation followed by proteolysis yielding non-farnesylated mature lamin A. Different inhibitors of these processing events are currently used therapeutically. Hutchinson-Gilford Progeria Syndrome (HGPS) is most commonly caused by mutations leading to an accumulation of a farnesylated LaA isoform, prompting a clinical trial using farnesyltransferase inhibitors (FTI) to reduce this modification. At therapeutic levels, HIV protease inhibitors (PI) can unexpectedly inhibit the final processing step in PreA maturation. We have examined the dynamics of LaA processing and associated cellular effects during PI or FTI treatment and following inhibitor washout. While PI reversibility was rapid, with respect to both LaA maturation and associated cellular phenotype, recovery from FTI treatment was more gradual. FTI reversibility is influenced by both cell type and rate of proliferation. These results suggest a less static lamin network than has previously been observed.PLoS ONE 05/2010; 5(5):e10874. DOI:10.1371/journal.pone.0010874 · 3.53 Impact Factor
Article: Activating transcription factor-2 affects skeletal growth by modulating pRb gene expression[Show abstract] [Hide abstract]
ABSTRACT: Endochondral ossification is the process of skeletal bone growth via the formation of a cartilage template that subsequently undergoes mineralization to form trabecular bone. Genetic mutations affecting the proliferation or differentiation of chondrocytes result in skeletal abnormalities. Activating transcription factor-2 (ATF-2) modulates expression of cell cycle regulatory genes in chondrocytes, and mutation of ATF-2 results in a dwarfed phenotype. Here we investigate the regulatory role that ATF-2 plays in expression of the pocket proteins, cell cycle regulators important in cellular proliferation and differentiation. The spatial and temporal pattern of pocket protein expression was identified in wild type and mutant growth plates. Expression of retinoblastoma (pRb) mRNA and protein were decreased in ATF-2 mutant primary chondrocytes. pRb mRNA expression was coordinated with chondrogenic differentiation and cell cycle exit in ATDC5 cells. Type X collagen immunohistochemistry was performed to visualize a delay in differentiation in response to loss of ATF-2 signaling. Chondrocyte proliferation was also affected by loss of ATF-2. These studies suggest pRb plays a role in chondrocyte proliferation, differentiation and growth plate development by modulating cell cycle progression. ATF-2 regulates expression of pRb within the developing growth plate, contributing to the skeletal phenotype of ATF-2 mutant mice through the regulation of chondrocyte proliferation and differentiation.Mechanisms of development 09/2008; 125(9-10):843-56. DOI:10.1016/j.mod.2008.06.010 · 2.24 Impact Factor
Article: Activating transcription factor 2 controls Bcl-2 promoter activity in growth plate chondrocytes[Show abstract] [Hide abstract]
ABSTRACT: Activating transcription factor 2 (ATF-2) is expressed ubiquitously in mammals. Mice deficient in ATF-2 (ATF-2 m/m) are slightly smaller than their normal littermates at birth. Approximately 50% of mice born mutant in both alleles die within the first month. Those that survive develop a hypochondroplasia-like dwarfism, characterized by shortened growth plates and kyphosis. Expression of ATF-2 within the growth plate is limited to the resting and proliferating zones. We have previously shown that ATF-2 targets the cyclic AMP response element (CRE) in the promoters of cyclin A and cyclin D1 in growth plate chondrocytes to activate their expression. Here, we demonstrate that Bcl-2, a cell death inhibitor that regulates apoptosis, is expressed within the growth plate in proliferative and prehypertrophic chondrocytes. However, Bcl-2 expression declines in hypertrophic chondrocytes. The Bcl-2 promoter contains a CRE at -1,552 bp upstream of the translation start. Mutations within this CRE cause reduced Bcl-2 promoter activity. We show here that the absence of ATF-2 in growth plate chondrocytes corresponds to a decline in Bcl-2 promoter activity, as well as a reduction in Bcl-2 protein levels. In addition, we show that ATF-2 as well as CREB, a transcription factor that can heterodimerize with ATF-2, bind to the CRE within the Bcl-2 promoter. These data identify the Bcl-2 gene as a novel target of ATF-2 and CREB in growth plate chondrocytes.Journal of Cellular Biochemistry 05/2007; 101(2):477-87. DOI:10.1002/jcb.21198 · 3.37 Impact Factor
- The Journal of Bone and Joint Surgery 02/2003; 85-A Suppl 2:133-6. · 4.31 Impact Factor
Article: The cyclin D1 and cyclin A genes are targets of activated PTH/PTHrP receptors in Jansen's metaphyseal chondrodysplasia.[Show abstract] [Hide abstract]
ABSTRACT: Jansen's metaphyseal chondrodysplasia (JMC) is an autosomal dominant disorder characterized by short-limbed dwarfism, delayed ossification, and hypercalcemia. Activating mutations in the PTH/PTHrP receptor have been identified as the molecular cause of this disorder. Although these mutations have been shown to increase cAMP accumulation, little is known about possible target genes of the downstream signaling pathways that may contribute to the pathogenesis of the disease. Here we demonstrate that JMC mutations of the PTH/PTHrP receptor induce activation of the cyclin D1 and cyclin A promoters in primary mouse chondrocytes and rat chondrosarcoma cells. Induction of cyclin D1 expression is required for stimulation of E2F-dependent transcription by mutant receptors. Activation of the cyclin D1 and cyclin A promoters requires a functional cAMP response element in both genes. Inhibition of protein kinase A or the transcription factor cAMP response element binding protein blocks the stimulation of both promoters by mutant receptors, whereas inhibition of activating transcription factor 2, c-Fos, or c-Jun has only minor effects. In summary, our data suggest that stimulation of cell cycle gene expression and cell cycle progression by mutant PTH/PTHrP receptors contribute to the pathogenesis of JMC.Molecular Endocrinology 10/2002; 16(9):2163-73. DOI:10.1210/me.2001-0103 · 4.20 Impact Factor
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ABSTRACT: Exact coordination of growth plate chondrocyte proliferation is necessary for normal endochondral bone development and growth. Here we show that PTHrP and TGF control chondrocyte cell cycle progression and proliferation by stimulating signaling pathways that activate transcription from the cyclin D1 promoter. The TGF pathway activates the transcription factor ATF-2, whereas PTHrP uses the related transcription factor CREB, to stimulate cyclin D1 promoter activity via the CRE promoter element. Inhibition of cyclin D1 expression with antisense oligonucleotides causes a delay in progres- sion of chondrocytes through the G1 phase of the cell cycle, reduced E2F activity, and decreased proliferation. Growth plates from cyclin D1- deficient mice display a smaller zone of proliferating chondrocytes, confirming the requirement for cyclin D1 in chondrocyte proliferation in vivo. These data identify the cyclin D1 gene as an essential component of chondrocyte proliferation as well as a fundamental target gene of TGF and PTHrP during skeletal growth.Molecular Biology of the Cell 01/2002; · 4.55 Impact Factor
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ABSTRACT: Beier, FMolecular Biology of the Cell 12/2001; 12:3852-63. DOI:10.1091/mbc.12.12.3852 · 4.55 Impact Factor
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ABSTRACT: Exact coordination of growth plate chondrocyte proliferation is necessary for normal endochondral bone development and growth. Here we show that PTHrP and TGFbeta control chondrocyte cell cycle progression and proliferation by stimulating signaling pathways that activate transcription from the cyclin D1 promoter. The TGFbeta pathway activates the transcription factor ATF-2, whereas PTHrP uses the related transcription factor CREB, to stimulate cyclin D1 promoter activity via the CRE promoter element. Inhibition of cyclin D1 expression with antisense oligonucleotides causes a delay in progression of chondrocytes through the G1 phase of the cell cycle, reduced E2F activity, and decreased proliferation. Growth plates from cyclin D1-deficient mice display a smaller zone of proliferating chondrocytes, confirming the requirement for cyclin D1 in chondrocyte proliferation in vivo. These data identify the cyclin D1 gene as an essential component of chondrocyte proliferation as well as a fundamental target gene of TGFbeta and PTHrP during skeletal growth.01/2001; 12(12):3852-63.
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ABSTRACT: Growth of endochondral bones is regulated by the coordinated proliferation and differentiation of chondrocytes in the epiphyseal growth plates. Many skeletal diseases are caused by pathogenic disruptions of these two processes. While the intracellular mechanisms regulating chondrocyte proliferation and differentiation are poorly understood, recent evidence from studies using genetically altered mice and from experiments in cultured chondrocytes point to a prominent role of cell cycle proteins in this context. This article summarizes our current understanding of the expression, regulation, and function of cell cycle genes in chondrocytes.Frontiers in Bioscience 06/2000; 5:D493-503. DOI:10.2741/LuValle · 4.25 Impact Factor
Article: Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes[Show abstract] [Hide abstract]
ABSTRACT: Endochondral bone growth is regulated through the proliferation and differentiation of growth plate chondrocytes. Mice deficient for the activating transcription factor 2 (ATF-2) gene show reduced proliferation of chondrocytes. Here we demonstrate that the cyclin A gene is a target of ATF-2 in chondrocytes. Serum stimulation of chondrogenic rat chondrosarcoma cells induces cyclin A expression. A cyclic AMP response element (CRE) is necessary for optimal activity and serum inducibility of the cyclin A promoter and confers regulation by ATF-2. Phosphorylation and activity of ATF-2 are enhanced dramatically upon serum stimulation of rat chondrosarcoma cells. Mutation of the CRE or overexpression of dominant-negative ATF-2 inhibits serum induction of the cyclin A promoter. Chondrocytes from ATF-2-deficient mice display reduced and delayed induction of cyclin A upon serum stimulation. The ATF-2-related transcription factor CRE-binding protein contributes to the activity of the cyclin A CRE in chondrocytes, whereas c-Jun and c-Fos regulate the promoter independently of the CRE. Our data suggest that the reduction in cyclin A levels in chondrocytes from ATF-2-deficient mice contributes to their phenotype of reduced chondrocyte proliferation and dwarfism.Journal of Biological Chemistry 05/2000; 275(17):12948-53. DOI:10.1074/jbc.275.17.12948 · 4.60 Impact Factor
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ABSTRACT: Skeletal development requires the integration of multiple extracellular signals into coordinated cellular responses. Repair of bone can be described as a regenerative process and, in essence, is the recapitulation of the molecular and cellular processes involved in formation of bone. The appendicular and axillary skeletal elements are formed by endochondral ossification, whereas most of the craniofacial bones are formed by intramembranous ossification. This article focuses on the signals and mechanisms that control endochondral bone formation and repair.Curr Opin Orthop 1999, 10:466-471© Lippincott Williams & Wilkins, Inc.Current Opinion in Orthopaedics 11/1999; 10(6):466-471. DOI:10.1097/00001433-199912000-00008
Article: The Raf-1/MEK/ERK Pathway Regulates the Expression of the p21Cip1/Waf1 Gene in Chondrocytes[Show abstract] [Hide abstract]
ABSTRACT: The gene encoding the cyclin-dependent kinase inhibitor p21(Cip1/Waf1) is up-regulated in many differentiating cells, including maturing chondrocytes. Since strict control of chondrocyte proliferation is essential for proper bone formation and since p21 is likely involved in this control, we initiated analyses of the mechanisms regulating expression of p21 in chondrocytes. p21 expression and promoter activity was strongly increased during the differentiation of chondrogenic MCT cells. We have identified a 68-base pair fragment conferring transcriptional up-regulation of the p21 gene in chondrocytes. The activity of this fragment required active Raf-1 in MCT cells as well as in primary mouse chondrocytes. Inhibition of downstream factors of Raf-1 (MEK1/2, ERK1/2, and Ets2) also repressed the activity of the 68-base pair fragment in MCT cells. The chemical MEK1/2 inhibitor PD98059 reduced protein levels of p21 in MCTs and primary mouse chondrocytes. These data suggest that signaling through the Raf-1 pathway is necessary for the optimal expression of p21 in chondrocytes and may play an important role in the control of bone formation.Journal of Biological Chemistry 11/1999; 274(42):30273-9. DOI:10.1074/jbc.274.42.30273 · 4.60 Impact Factor
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ABSTRACT: The collagen X gene is expressed exclusively by differentiated, hypertrophic chondrocytes. The mechanisms controlling collagen X expression remain largely unknown. Here we show that collagen X promoter activity can be induced by serum stimulation of chondrogenic MCT cells. The serum response is conferred by a 462 nucleotide promoter fragment. Both the c-Raf/MEK/ERK and p38 MAP kinase pathways are required for this effect, whereas phosphatidylinositol-3-kinase and protein kinase A repress promoter activation. These data are the first to demonstrate serum inducibility of the collagen X promoter and to identify signal transduction pathways involved.Biochemical and Biophysical Research Communications 09/1999; 262(1):50-4. DOI:10.1006/bbrc.1999.1178 · 2.28 Impact Factor
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ABSTRACT: Coordinated proliferation and differentiation of growth plate chondrocytes controls longitudinal growth of endochondral bones. While many extracellular factors regulating these processes have been identified, much less is known about the intracellular mechanisms transducing and integrating these extracellular signals. Recent evidence suggests that cell cycle proteins play an important role in the coordination of chondrocyte proliferation and differentiation. Our current knowledge of the function and regulation of cell cycle proteins in endochondral ossification is summarized.Matrix Biology 05/1999; DOI:10.1016/S0945-053X(99)00009-8 · 3.65 Impact Factor
Article: Raf signaling stimulates and represses the human collagen X promoter through distinguishable elements[Show abstract] [Hide abstract]
ABSTRACT: Endochondral bone growth is regulated through the rates of proliferation and differentiation of growth plate chondrocytes. While little is known about the intracellular events controlling these processes, the protein kinase c-Raf, a central component of the cellular signal transduction machinery, has recently been shown to be expressed only by differentiated, hypertrophic chondrocytes. The involvement of c-Raf in the transcriptional regulation of the hypertrophic chondrocyte-specific collagen X gene was investigated using cotransfections of collagen X reporter plasmids and expression vectors for mutant c-Raf proteins. Both activated and dominant-negative forms of c-Raf reduced the activity of the collagen X promoter to approximately 30%. The element mediating the repressing effect of activated c-Raf was located between nucleotides -2864 and -2410 of the promoter, whereas the effect of the dominant-negative form of c-Raf was conferred by the 462 nucleotides immediately upstream of the transcription start site. Inhibition of MEK1/2 and ERK1/2, downstream components of Raf-signaling, also caused repression of basal collagen X promoter activity. These data suggest that c-Raf regulates collagen X promoter activity positively and negatively through different cis-acting elements and represent the first evidence of c-Raf activity described in hypertrophic chondrocytes.Journal of Cellular Biochemistry 04/1999; 72(4):549-57. DOI:10.1002/(SICI)1097-4644(19990315)72:4<549::AID-JCB10>3.0.CO;2-1 · 3.37 Impact Factor
Article: Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes[Show abstract] [Hide abstract]
ABSTRACT: Endochondral bone growth is regulated by the rates of chondrocyte proliferation and differentiation. However, the intracellular mechanisms regulating these processes are poorly understood. Recently, interruption of the gene encoding the transcription factor activating transcription factor 2 (ATF-2) was shown to inhibit proliferation of chondrocytes in mice [Reimold, A. M., et al. (1996) Nature (London) 379, 262–265]. The target genes of ATF-2 that are responsible for this phenotype remain unknown. Here we report that the cyclin D1 gene is a direct target of ATF-2 in chondrocytes. ATF-2 is present in nuclear extracts from chondrogenic cell lines and binds, as a complex with a CRE-binding protein (CREB)/CRE modulator protein, to the cAMP response element (CRE) in the cyclin D1 promoter. Mutation of the cyclin D1 CRE caused a 78% reduction in the activity of the promoter in chondrocytes. Overexpression of ATF-2 in chondrocytes enhanced activity of the cyclin D1 promoter 3.5-fold. In contrast, inhibition of endogenous ATF-2 or CREB by expression of dominant-negative inhibitors of CREB and ATF-2 significantly reduced the activity of the promoter in chondrocytes through the CRE. In addition, levels of cyclin D1 protein are greatly reduced in the chondrocytes of ATF-2-deficient mice. These data identify the cyclin D1 gene as a direct target of ATF-2 in chondrocytes and suggest that reduced expression of cyclin D1 contributes to the defective cartilage development of these mice.Proceedings of the National Academy of Sciences 03/1999; DOI:10.1073/pnas.96.4.1433 · 9.81 Impact Factor
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ABSTRACT: Bone morphogenetic proteins (BMPs) were originally identified by their ability to induce ectopic bone formation and have been shown to promote both chondrogenesis and chondrocyte hypertrophy. BMPs have recently been found to activate a membrane serine/threonine kinase signaling mechanism in a variety of cell types, but the downstream effectors of BMP signaling in chondrocyte differentiation remain unidentified. We have previously reported that BMP-2 markedly stimulates type X collagen expression in prehypertrophic chick sternal chondrocytes, and that type X collagen mRNA levels in chondrocytes cultured under serum-free (SF) conditions are elevated 3- to 5-fold within 24 h. To better define the molecular mechanisms of induction of chondrocyte hypertrophy by BMPs, we examined the effect of BMPs on type X collagen production by 15-day chick embryo sternal chondrocytes cultured under SF conditions in the presence or absence of 30 ng/ml BMP-2, BMP-4, or BMP-7. Two populations of chondrocytes were used: one representing resting cartilage isolated from the caudal third of the sterna and the second representing prehypertrophic cartilage from the cephalic third of the sterna. BMP-2, BMP-4, and BMP-7 all effectively promoted chondrocyte maturation of cephalic sternal chondrocytes as measured by high levels of alkaline phosphatase, diminished levels of type II collagen, and induction of the hypertrophic chondrocyte-specific marker, type X collagen. To test whether BMP control of type X collagen expression occurs at the transcriptional level, we utilized plasmid constructs containing the chicken collagen X promoter and 5' flanking regions fused to a reporter gene. Constructs were transiently transfected into sternal chondrocytes cultured under SF conditions in the presence or absence of 30 ng/ml BMP-2, BMP-4, or BMP-7. A 533 bp region located 2.4-2.9 kb upstream from the type X collagen transcriptional start site was both necessary and sufficient for strong BMP responsiveness in cells destined for hypertrophy, but not in chondrocytes derived from the lower sterna.Journal of Bone and Mineral Research 11/1998; 13(10):1521-9. DOI:10.1359/jbmr.19126.96.36.1991 · 6.59 Impact Factor
Article: Proximal DNA elements mediate repressor activity conferred by the distal portion of the chicken collagen X promoter[Show abstract] [Hide abstract]
ABSTRACT: Collagen X is expressed specifically in hypertrophic chondrocytes within cartilage that is undergoing endochondral ossification. The chicken collagen X gene is transcriptionally regulated, and under the control of multiple cis elements within the distal promoter region (-4,442 to -558 base pairs from the transcription start) as well as the proximal region (-558 to +1). Our previous data (LuValle et al., [1993] J. Cell Biol. 121:1173-1179) demonstrated that the proximal sequence directed high reporter gene activity in the three cell types tested (hypertrophic chondrocytes, immature chondrocytes, and fibroblasts), while distal elements acted in an additive manner to repress the effects of the proximal sequence on reporter gene activity in non-collagen X expressing cells only (immature chondrocytes and fibroblasts). We show here that elements within the proximal sequence (nucleotides -557 to -513) are necessary for the cell-specific expression of type X collagen by hypertrophic chondrocytes. These elements bind to proteins of 100 kDa in all three cell types, and 47 kDa in non-collagen X expressing cells. Reporter gene activity in hypertrophic chondrocytes is reduced to the levels seen in non-collagen X-expressing cells in the absence of these elements.Journal of Cellular Biochemistry 10/1998; 70(4):507-16. DOI:10.1002/(SICI)1097-4644(19980915)70:43.0.CO;2-N · 3.37 Impact Factor
Article: Variability in the upstream promoter and intron sequences of the human, mouse and chick type X collagen genes.[Show abstract] [Hide abstract]
ABSTRACT: The type X collagen gene is specifically expressed in hypertrophic chondrocytes during endochondral ossification. Transcription of the type X collagen gene by these differentiated cells is turned on at the same time as transcription of several other cartilage specific genes is switched off and before mineralization of the matrix begins. Analysis of type X collagen promoters for regulatory regions in different cell culture systems and in transgenic mice has given contradictory results suggesting major differences among species. To approach this problem, we have determined the nucleotide sequences of the two introns and upstream promoter sequences of the human and mouse type X collagen genes and compared them with those of bovine and chick. Within the promoter regions, we found three boxes of homology which are nearly continuous in the human gene but have interruptions in the murine gene. One of these interruptions was identified as a complex 1.9 kb repetitive element with homology to LINE, B1, B2 and long terminal repeat sequences. Regulatory elements of the human type X collagen gene are located upstream of the region where the repetitive element is inserted in the mouse gene, making it likely that the repetitive element is inserted between the coding region and regulatory sequences of the murine gene without interfering with its expression pattern. We also compared the sequences of the introns of both genes and found strong conservation. Comparisons of the mammalian sequences with promoter and first intron sequences of the chicken type X collagen gene revealed that only the proximal 120 nucleotides of the promoter were conserved, whereas all other sequences displayed no obvious homology to the murine and human sequences.Matrix Biology 01/1997; 15(6):415-22. DOI:10.1016/S0945-053X(96)90160-2 · 3.65 Impact Factor
Top Journals
University of Florida
Gainesville, Florida, United States
- Department of Anatomy and Cell Biology
The University of Western Ontario
London, Ontario, Canada
- Department of Physiology and Pharmacology
The University of Calgary
Calgary, Alberta, Canada
- Department of Biochemistry and Molecular Biology
Harvard Medical School
Boston, Massachusetts, United States
- Department of Cell Biology


text: The Overmaster wiki last edited by Darkside_of_the_Sun on 12/24/14 02:41AM View full history OriginAn alien parasite once latched on to another moutainous alien; The combined being took the name Overmaster and journeyed through space, interfering with sentient worlds. When this being arrived on Earth, it saw a planet full of super heroes and recognised a new way to test the populace. Overmaster recruited 6 humans and formed the Cadre. This group challenged the Justice League to battle with the fate of humanity at stake. The JLA prevailed. Overmaster returned for man's "Judgement Day" and again faced the League.It is not known how long he has wandered the cosmos before arriving at Earth, but along the way he accumulated many alien prisoners, many of whom are the last of their race, including Yazz.


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The purpose of this study is to determine if lamotrigine is associated with greater improvement in declarative memory than placebo in patients receiving prescription corticosteroids. We will also examine if lamotrigine is associated with greater improvement in working memory and other cognitive domains, and mood symptoms than placebo.
Project Summary
The study is open to all English-speaking men and women age 18-70 years. The patients must be taking at least 5 mg of prednisone or prednisolone, or at least 4 mg of methylprednisolone for at least 6 months, with anticipated treatment for at least another 15 months.
The duration of the study is 60 months, with appointments every 2 weeks for the first 12 weeks, and then once every 12 weeks until week 60. The patients will be given various mood, memory, and health assessments during the study.
The study also includes two MRI scans, and as such patients with metal implants close to the head or claustrophobia will not be good candidates for the study. Participants must not have a history of mood disorders such as depression, bipolar disorder, and schizophrenia that is unrelated to corticosteroid use.
Moreover, any conditions involving the central nervous system including multiple sclerosis, brain tumor, and seizures, and a lifetime history of drug and alcohol dependence are exclusions for the study. We encourage all patients to call the researchers to be screened for the study criteria.
Stress and corticosteroid exposure are associated with changes in both the human and animal hippocampus. An extensive literature suggests that corticosteroid-induced changes in the hippocampus are, in part, mediated through increases in extracellular glutamate.
In animals, agents that decrease glutamate release prevent dendritic changes in the hippocampus secondary to stress or corticosterone. We have developed a research program using patients receiving prescription corticosteroids (e.g., prednisone) to explore the effects of corticosteroids on the human hippocampus.
Our research program is translational in focus, with a goal of exploring whether the reported effects of corticosteroids on the animal hippocampus are also found in humans.
A current focus of our research is examining glutamate release inhibitors in patients taking corticosteroids. We have both open-label and placebo-controlled pilot data suggesting that the glutamate release inhibitor lamotrigine is associated with significant improvement in declarative memory (a measure of hippocampal performance) in this population.
A definitive study examining declarative memory in corticosteroid-dependent patients receiving lamotrigine vs. placebo is proposed. Neuroimaging and mood will also be assessed.
Frequently Asked Questions
Q: Is compensation available for participation in the study?
A: Yes, patients will be paid for each visit in the study. Patients will also be paid for the successful completion of MRI scans for baseline and week 48 visits.
Q: Is transportation available for the study appointments?
A: Yes. DART passes will be provided for each study visit to cover transportation costs.


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Wher can i get a free psychic reading without credit card?
I'm not doing well finacially and I'm going through some hard struggles and I just need to know please…?
Suggestion by Rozie
Here is a link where you can get free psychic reading : http://www.meryem.com/free-psychic-readings.aspx
What do you think? Answer below!
What do I need to know about getting a 900 number?
I am seriously considering starting my own business offering tarot readings. I am confident that I can offer a valuable service to callers as God has blessed me with psychic abilities.
What is involved in having a phone service…..about how much are the costs….what is the best company to provide the 900 service, how costly is it to accept credit cards for my readings….etc.
Suggestion by Brutus
Just read the cards.
Suggestion by vid
Well, if you are "genuine" you could probably do something different than a 900 line. For instance, there are some very good psychics out there that charge a flat fee for 30 or 60 minutes. They then call the person they are going to read for, or have the person call them. Generally, it's cheaper for the "reader" to get free long distance on their phone, but if you'll be doing out of the country readings it might be cheaper for people to call you. Anyway, it's completely ridiculous to do a 900 number. One of the main reasons is they are generally viewed as a rip-off and a scam, and most self-respecting people do not trust them. Instead, people tend to find a reader or "psychic" online and then set up a reading with them–via phone, messenger, or email. That in my opinion is one of the best ways. Also, you could only accept paypal on your website, and that makes it much easier for payment because anyone with a credit card could use paypal.
Hope that helps, but again, if you started a 900 number I'm sure you would be let down because not too many people call them anymore. I mean, do you really see the psychic infomercials like we did in the 1990s? No, and the reason is because people don't call them so much anymore!
What do you think? Answer below!