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Below are current clinical trials.
Filter this list of studies by location, status and more.
Scottsdale/Phoenix, Ariz., Jacksonville, Fla.
Describes the nature of a clinical study. Types include:
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
This global, multicenter, open-label study will evaluate the safety and tolerability of MPDL3280A in combination with other immune-modulating therapies in the treatment of selected advanced or metastatic malignancies. The MPDL3280A plus ipilimumab arm (Arm A) will focus primarily on patients with advanced or metastatic NSCLC. The MPDL3280A plus interferon alfa-2b arm (Arm B) will enroll patients with advanced or metastatic RCC and melanoma. MPDL3280A will be administered intravenously every 3 weeks (q3w).
Study statuses change often. Please contact us for help.
Open for enrollment
Jacksonville, Fla., Rochester, Minn.
This phase I trial studies the side effects and the best dose of pazopanib hydrochloride in treating patients with advanced or refractory solid tumors. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
The primary objectives of this study are to assess the safety profile, characterize pharmacokinetics (PK) and determine the dosing schedule, maximum tolerated dose (MTD), and the recommended phase two dose (RPTD) of ABT-199 when administered in subjects with relapsed /refactory multiple myeloma who are receiving bortezomib and dexamethasone as their standard therapy.
Jacksonville, Fla.
The purpose of this study is to test safety and anti-tumor activity of BT062 in combination with lenalidomide and dexamethasone to define the best doses for treating patients with relapsed and refractory multiple myeloma.
The purpose of this study is to determine if lenalidomide (Revlimid®) is safe and effective as a maintenance therapy at improving further the quality of the response you achieved with your last therapy and at prolonging the duration of your response. This study will compare the effects (good and bad) of lenalidomide with the dummy drug.
To document impact of EUS-FNA needle size and flexibility on effectiveness of pancreatic cystic lesions (PCL) aspiration, on ability to obtain sufficient material for standard diagnostic testing, and on diagnostic accuracy of EUS-FNA aspirate for differentiation of mucinous (pre-malignant) and non-mucinous cysts.
Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn.
This phase II trial studies how well proteasome inhibitor MLN9708 works in treating patients with relapsed multiple myeloma that is not refractory to bortezomib. Proteasome inhibitor MLN9708 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Contact us for the latest status
Rochester, Minn.
RATIONALE: Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor. Drugs used in chemotherapy, such as gemcitabine hydrochloride, work in different ways to stop the growth or tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving sunitinib malate and gemcitabine hydrochloride together is more effective than sunitinib malate alone in treating patients with kidney cancer.
PURPOSE: This randomized phase II clinical trial is studying giving sunitinib malate together with or without gemcitabine hydrochloride to see how well they work in treating patients with advanced kidney cancer that cannot be removed by surgery.
This randomized phase II-R/III trial studies gemcitabine hydrochloride with or without erlotinib hydrochloride followed by the same chemotherapy regimen with or without radiation therapy and capecitabine or fluorouracil in treating patients with pancreatic cancer that was removed by surgery. Drugs used in chemotherapy, such as gemcitabine hydrochloride, capecitabine, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays to kill tumor cells. Giving chemotherapy together with or without erlotinib hydrochloride and/or radiation therapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether chemotherapy is more effective when given with or without erlotinib hydrochloride and/or radiation therapy in treating pancreatic cancer.
Closed for enrollment
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known whether giving temozolomide during and/or after radiation therapy is more effective than radiation therapy alone in treating anaplastic glioma.
PURPOSE: This randomized phase III trial is studying giving temozolomide during and/or after radiation therapy to see how well it works compared to radiation therapy alone in treating patients with anaplastic glioma.
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SEASIDE HEIGHTS, N.J. (AP) — The waterfront rides on Casino Pier are gone, swallowed by the sea. A roller coaster bobs lazily in the waves. Sand, leaves and debris choke roads lined with houses that rest on their sides.
Storm washes away much of 'Jersey Shore' town
The barrier island home to Seaside Heights and other communities where legions of vacationers from New Jersey and beyond made summer memories is a scene of devastation days after superstorm Sandy's surge enveloped it.
Seaside Heights, where families have walked the boardwalk, eaten fried dough and ridden amusement park rides for generations, is in ruins. The boardwalk made famous by MTV's hit reality show "Jersey Shore" has been destroyed, with parts of it sticking straight up. Sand pushed up from the beach fills the road parallel to it.
The rides at Casino Pier, a waterfront amusement park, vanished under the Atlantic Ocean's power. A roller coaster from the Funtown Pier sat in the ocean. Roofs were ripped off houses, and utility poles were snapped in two, with their power lines tangled like shoelaces.
The house where the "Jersey Shore" cast lived appeared to avoid any damage. But elsewhere on the island — technically a long, narrow peninsula — boats had been tossed like toys, resting atop houses and cars. One lay next to a motel.
About 300 people have been taken off the island since the storm passed, public safety officials said. About 70 remain and will be ordered to leave and not allowed to return to the island until at least the weekend.
"We have to get everyone off the island because there is total devastation," Seaside Heights Police Chief Thomas Boyd said Wednesday at a news conference.
In Ortley Beach, a section of the community of Toms River, sinkholes swallowed roads, roofs caved in and homes lay on their sides, separated from passable roads by pools of water.
Continue reading this story on the...

subset: commoncrawl


text: Kim Kardashian Makeover: Fab Or Fail? Kate Spencer | April 21, 2009 6:30 am When exotic looker Kim Kardashian first hit up the Hollywood scene, she was just another Paris Hilton knock-off – crashing D-List events while flaunting her booty in barely-there outfits. These days, Kim's chucked the cheesiness for a look that's more classic, simple and sleek. But the starlet didn't just swap out her trashy clothes for a chicer look – she's also adopted a macrobiotic diet and slimmed down from a size 6 to a size 2 – all for the sake of looking fierce. Kim also hit to the gym to help tone her eye-catching booty, after she grew tired of the frenzy her fanny caused. "I love that I'm curvy, but I'm on this major kick to try and lose weight, especially in my butt," she told Radar magazine in March 2009. "I'm just so over it! When you're posing on the red carpet and the paparazzi shout, 'Turn around! Turn around!' — it gets a little offensive." Do you prefer Kim back when she was an unknown, bootylicious babe or is her current slimmed down, high fashion look more your speed? View Photo Gallery 0


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Ablation of the pulmonary veins causes damage to the tissue which may affect the viability of the tissue. By placing a stent, a vascular endoprosthesis, within a target pulmonary vein it is possible to protect the functionality of the veins after the ablation procedure. Placement of a stent, endoprosthesis or mere circuit interrupting structure into a target pulmonary vein, without ablation, prevents aberrant electrical activity in the pulmonary veins from interfering with the electrical activity of the left atrium. The stent, endoprosthesis or circuit interrupting structure may also be coated or comprised of a drug-eluting compound, loaded with a drug which inhibits arrhythmia.
1. A drug delivery stent comprising:
a stent; and
a drug-eluting coating on the stent, said drug eluting coating comprising a drug;
the stent having a first longitudinal region through which the drug is eluted and a second longitudinal region through which the drug is not eluted;
wherein the drug is an antiarrhythmic drug.
2. A drug delivery stent comprising:
a stent;
a drug-eluting compound uniformly covering the stent;
a small first longitudinal region of the drug-eluting compound being capable of eluting a drug; and
a cover disposed over a second longitudinal region of the drug eluting compound that prevents elution of a drug from the second longitudinal region;
wherein the drug is an antiarrhythmic drug.
3. A drug delivery stent comprising:
a stent;
a drug incorporated into the stent; and
a coating covering a substantial longitudinal portion of the stent, said coating inhibiting elution of the drug from the stent in said longitudinal portion, the drug being eluted from the portion of the stent not covered by the coating;
wherein the drug is an antiarrhythmic drug.
4. A drug delivery stent comprising:
a stent;
a drug-eluting compound, uniformly covering the stent, the drug-eluting compound comprising a drug; and
a coating covering a first longitudinal portion of the drug-eluting compound, said coating impeding the elution of the drug from the stent, whereby the drug is eluted from the portion of the drug-eluting compound not covered by the coating;
wherein the drug is an antiarrhythmic drug.
5. A drug delivery stent comprising:
a stent having a first longitudinal region and a second longitudinal region;
a first coating disposed on the stent, said first coating capable of eluting a drug;
a second coating disposed on the stent and over the first coating, said second coating capable of inhibiting the drug from eluting;
wherein the second coating covers the first longitudinal region of the stent such that the drug may elute only from the second longitudinal region of the stent;
wherein the drug is an antiarrhythmic drug.
6. A drug delivery stent comprising:
a stent having a first longitudinal region and a second longitudinal region;
a first coating disposed on the stent on the first longitudinal region and the second longitudinal region, said first coating comprising a drug and a compound capable of eluting the drug;
a second coating disposed on the stent and over the first coating, said second coating being impermeable to the drug;
wherein the second coating is limited to the second longitudinal region of the stent such that the drug may elute only from the first longitudinal region of the stent;
wherein the drug is an antiarrhythmic drug.
This patent application claims priority to provisional patent application No. 60/159,343, filed Oct. 13, 1999.
The inventions described below relate to the field of implantable medical devices. Specifically the invention relates to endoluminally placed prosthesis known as stents. More specifically, the invention relates to the placement of stents in the pulmonary veins which have advantages for the treatment of atrial fibrillation.
Atrial fibrillation (AF) is a form of heart disease that afflicts millions of people. It is a condition in which the normal contraction of the heart is interrupted, primarily by abnormal and uncontrolled action of the atria of the heart. The heart has four chambers: the right atrium, right ventricle, the left ventricle, and the left atrium. The right atrium pumps de-oxygenated blood from the vena cava to the right ventricle, which pumps the blood to the lungs, necessary for return flow of de-oxygenated blood from the body. The right atrium contracts to squeeze blood into the right ventricle, and expands to suck blood from the vena cava. The left atrium pumps oxygenated blood from the pulmonary veins (returning from the lungs), necessary for flow of oxygenated blood from the lungs. The left atrium contracts to squeeze blood into the left ventricle, which then pumps the blood into the aorta and thence to the entire body, and expands to suck blood from the pulmonary veins. The contractions of the atria normally occur in a controlled sequence with the contractions of the other chambers of the heart. When the left atrium or the right atrium fails to contract, contracts out of sequence, or contracts ineffectively, blood flow within the heart is disrupted. The disruption of the normal rhythm of contraction is referred to as an arrhythmia. The arrhythmia, known as atrial fibrillation, can cause weakness of the heart due to reduced ventricular filling and reduced cardiac output, stroke due to clot formation in a poorly contracting atria, which may lead to brain damage and death, and even life threatening ventricular arrhythmias.
There is a broad spectrum of situations which fall under the broad heading of AF. For example, in older patients where there is substantial heterogeneity in the conduction within the atrial tissue, the patient is said to have the tissue substrate for AF such that any trigger will result in maintaining AF. In younger patients, the tissue may have more homogeneous conduction and be less likely to have sustained AF. In the younger patient it may be the often reoccurrence of a premature depolarizing tissue which acts as a trigger that causes the clinical manifestation of problematic episodes of AF. Clearly, there is a continuous spectrum of degrees of triggered AF and conduction heterogeneity which acts as a substrate for this arrhythmia, and it is appropriate that a number of medical therapies are being developed to treat this disease.
Atrial fibrillation may be treated with an atrial defibrillator. Atrial defibrillators are typically implantable electrical therapy devices which deliver defibrillating energy to the atrium to terminate arrhythmias. They sense the electrical activity of the atrium and deliver an electrical shock to the atrium when the electrical activity indicates that the atrium is in fibrillation. Electrical defibrillation has two major problems: the therapy causes substantial pain, and has the potential to initiate a life threatening ventricular arrhythmias. The pain associated with the electrical shock is severe and unacceptable for many patients. Unlike electrical ventricular defibrillators, where the patient loses consciousness prior to receiving therapy, the patient who suffers an atrial arrhythmia is conscious and alert when the device delivers electrical therapy.
The potential for inappropriate induction of ventricular fibrillation by the shock intended to defibrillate the atrium exists. The induction of ventricular fibrillation has great potential to result in death in just a few minutes if no intervening therapy is provided. Even with careful algorithms to deliver shocks to the periods in the ventricular contraction cycle when the heart is not susceptible to shock induced ventricular fibrillation, the risk of setting off a ventricular fibrillation remains substantial.
Doctors have treated atrial fibrillation with drugs injected intravenously or administered orally. Recent literature describes the potential for the delivery of drugs to the heart on demand to terminate arrhythmias. The concept has been suggested for use in the atrium to treat atrial fibrillation. Arzbaecher, Pharmacologic Atrial Defibrillator and Method, U.S. Pat. No. 5,527,344 (Jun. 18, 1996) describes a pharmacological atrial defibrillator and method for automatically delivering a defibrillating drug into the bloodstream of a patient upon detection of atrial arrhythmias in order to terminate the atrial arrhythmias. Arzbaecher teaches that unspecified defibrillating drugs should be injected into the bloodstream with a large initial dose followed by delivery of a continuous smaller dose (this is the "two-compartment pharmacokinetic model" discussed in the Arzbaecher patent). By delivering agents to a blood vessel and maintaining a therapeutic level of drugs in the blood stream, Arzbaecher requires systemic effects to be achieved in order to terminate atrial arrhythmias. In other words, if drugs injected according to Arzbaecher are to have any effective concentrations within the heart, then a large amount must be injected in the blood stream to ensure that an adequate dose is delivered to the affected area of the heart. While the drugs are in the blood stream, they are available throughout the body to cause side effects on all other organs.
There are several disadvantages to the transient introduction of systemic drug levels by an implantable device. Systemic effects resulting from such delivery may result in detrimental effects to ventricular cardiac conduction. These detrimental effects could be life threatening, and several studies suggest that use of these drugs actually leads to higher mortality. The large amount of drugs required for systemic delivery of therapeutic doses demands a larger, less comfortable device than smaller dosages would allow. The large quantity of drug in the implantable reservoir of such a system is potentially more dangerous if it develops a leak or is ruptured. Such a large single dosage requires a reservoir that requires frequent follow-ups for refilling post therapy by a clinician. Lastly, the large quantity of drugs required to obtain therapeutic levels in the entire body may cost substantially more than that required to treat a specific site within the heart.
Atrial fibrillation can be treated by atrial ablation. There are two general approaches for providing ablative therapy to the heart for the treatment of atrial fibrillation. These shall be called the long linear ablative lesion approach and the focal ablation approach.
In the long linear lesion approach, the heart tissue is killed along a linear pathway. The cardiac electrophysiologist does this to segment the heart into regions which are too small to sustain atrial fibrillation. Such an approach is very similar to performing the Maze procedure using radiofrequency, microwave, and ultrasound ablative energy sources on the end of catheters. In the Maze procedure, a number of incisions are made with a scalpel in an attempt to terminate inappropriate accessory pathways.
In the focal ablation approach, the heart tissue is killed at a single site. The cardiac electrophysiologist attempts to ablate the region of the heart that prematurely depolarizes, and which has been described as acting as a trigger for the initiation of atrial fibrillation. Recently, work in ablating regions at the junction of the pulmonary veins and the left atrium has been performed. Such ablations remove the possibility of triggers for AF initiating within the pulmonary veins, or at the region near the junction of the veins with the left atrial tissue. Such ablations may also remove disturbances introduced into the conduction pathway by the heterogeneity of the junction region anatomy.
Focal ablation of the region within or adjacent to the pulmonary vein to terminate atrial fibrillation with different energy transfer techniques such as cryoablation, RF ablation, laser ablation, ultrasound ablation, and microwave ablation causes damage to the tissue which may affect the viability of the tissue. By placing a stent, a vascular endoprosthesis, within a target pulmonary vein it is possible to protect the functionality of the veins after the ablation procedure.
In some cases, placement of a stent, endoprosthesis or mere circuit interrupting structure into the pulmonary veins prevents aberrant electrical activity in the pulmonary veins from interfering with the electrical activity of the left atrium and thereby eliminate the need for destructive ablation. The stent, endoprosthesis or circuit interrupting structure may be coated or comprised of a drug-eluting compound, loaded with a drug which inhibits arrhythmia. Embodiments include a new indication for maintaining vessel patency after a destructive ablation procedure, and the use of a stent both with and without local drug delivery to disrupt the electrical contribution of the pulmonary veins to atrial electrical activity leading to the induction and maintenance of atrial fibrillation.
FIG. 1 is a cross-sectional view of the left atrium with the stent deployed into the target pulmonary vein.
FIG. 2 is a schematic of a drug elution stent.
FIG. 3 is a schematic of a drug elution stent where only a narrow band of the stent is covered with a drug eluting compound.
FIG. 4 is a schematic of a drug elution stent having a uniform coating of drug eluting compound and a coating covering a substantial portion of the stent such that the drug is eluted from a narrow band of the stent.
FIG. 5 is an isometric view of the left atrium having a stent deployed into the ostium of the target pulmonary vein, wherein the drug-eluting band is proximate the left atrium.
In FIG. 1 the stent 1 has been deployed, by the catheter 2, into the ostium 3 of the target pulmonary vein 4. The stent alone acts to isolate the electrical impulses of the pulmonary veins from the atrial conduction tissue. The stent, endoprosthesis or circuit interrupting structure is placed into the ostium of the target pulmonary veins. The term "stent" is being used in its broad sense as is meant to encompass a stent, endoprosthesis or a circuit interrupting structure. The stent, when fabricated of a material with desirable electrical properties (for example, metal, which has a low resistivity) may comprise the circuit interrupting structure. To place the stent in the target pulmonary vein, access to the left atrium 5 is first gained by percutaneous insertion of a catheter into the left atrium. To accomplish this, a needle catheter is placed through the venous system into the right atrium, and then penetrates the fossa ovalis 6 (the atrial septum) to gain access to the left atrium. Access to the right atrium (not shown) can be through the femoral vein in the thigh and the inferior vena cava, or may be through the subclavian vein, brachial vein or cephalic vein, etc., in the shoulder and arm, and then through the superior vena cava. A catheter sheath 7, such as a guiding catheter, is advanced over the needle catheter and is inserted into the left atrium. The needle catheter is then removed, and a stent delivery catheter is inserted with a stent loaded on the distal end of the catheter. The distal end of the catheter is then maneuvered into the left atrium and into the target pulmonary veins. Location of the stent is confirmed and the stent is expanded or released, and expanded to the point where it securely engages the wall of the pulmonary vein. If necessary, the stent may be pressed into the wall of the pulmonary vein, and may have fastening appendages such as barbs, to more securely attach to the pulmonary vein wall.
As previously noted, placement of the stent alone can act to isolate the target pulmonary vein from the atrial conduction and excitation process. The primary advantage of this method is that no tissue is damaged. The ramifications regarding the viability of the pulmonary veins long term is obvious. Less obvious is the fact that the non-damaging procedure can be reversed, if desired. This stent device may operate by acting as an electrically insulative barrier to an electrical signal, a capacitively coupled short across the region of tissue in question, an averager that reduces the effective signal of the myocardial region in question, a substrate for the delivery of pharmacological agents to alter the electrical excitation and conduction properties of the local tissue region, or any combination of these mechanisms. The preferred embodiment incorporates local delivery of therapeutic agents to a region equivalent to the lumen wall on the outer wall of the stent.
Where placement of the stent is accomplished without an accompanying ablation procedure, the device may be fabricated in various forms. A nonconductive embodiment of any of the different possible geometries of the device will act as an insulative barrier preventing conduction through the device, and acting similarly to a region of necrotic tissue created by ablation. There is one fundamental difference: the device disclosed here changes the cellular conductivity locally without destroying tissue.
The conductive embodiments of the device act as a short across the pulmonary vein region which may introduce a triggered premature depolarization of cells. By electrically connecting the tissue around the arrhythmogenic site, the cells on either side of a conductive device will be coupled capacitively to the device and therefore to each other.
Metals are very efficient conductors of electrons, but not for ions. On the other hand, aqueous electrolyte solutions are ionic conductors and are hostile to electrons. Consequently, at the interface between a metal and an aqueous electrolyte solution, there is a mismatch in the type of charge carrier used. In the absence of a chemical mechanism to convert one type of charge into the other, the interface behaves as a capacitance: a change in the electronic charge density on the metal side is accompanied by a compensating change in ionic charge density on the solution side, so that electroneutrality is maintained.
The two types of charges can come very close to each other spatially without the possibility of neutralizing each other. This gives rise to an interfacial capacitance. [de Levie, Robert: The Admittance of the Interface between a Metal Electrode and an Aqueous Electrolyte Solution: Some Problems and Pitfalls, pp337-347 Annals of Biomedical Engineering, Special Issue]. Typically the interface between a metal and tissue is modeled as a resistor and a capacitor in parallel; at low currents the impedance associated with the capacitive leg of the circuit is small and the impedance associated with the resistive leg is large. Thus, any electrical discharge from electrically active tissue on the pulmonary vein side of the stent, or underlying the stent, will be hindered in its transmission to the atrium thereby limiting its ability to initiate an atrial fibrillation in the left atrium. Different biocompatible metals such as Platinum Iridium Alloys, ND35N, Titanium, nitinol, and Stainless Steels may be selected for different capacitive and resistive effects.
If pulmonary vein ablation is to be performed as the primary therapy and the stent is to be used to maintain pulmonary vein patency after ablation, then the necessary ablation catheter is passed through the catheter sheath into the left atrium to gain access to the pulmonary veins and perform the ablation prior to stent placement. The ablation catheter may be placed within the opening of the pulmonary veins or adjacent to the pulmonary veins to produce lesions using radiofrequency, ultrasound, microwave, laser, cryogenic or other energy transfer means as well as chemical means to kill the tissue locally. The damaged pulmonary vein or veins are now at risk for stenosis and stenting the pulmonary vein avoids the resulting pulmonary hypertension or occlusion. Stenting is performed by removing the ablation catheter of choice, and inserting a stenting catheter. The stenting catheter may use balloon expandable, self-expanding, or other types of expanding stents to maintain the patency of the pulmonary vein.
After one or more stents are placed in the pulmonary veins, with one or more catheters swapped out through the catheter sheath, the catheter sheath is removed, and the patient is closed. In most cases the opening through the fossa ovalis is very small and it heals up on its own. However, it is conceivable that a repair may be required in some patients using catheter techniques developed for closing septal defects.
The stent may be coated with a drug delivery compound or it may be partially made of a drug delivery compound. The stent is placed such that it delivers a sustained release of an antiarrhythmic drug which affects conduction locally. There are a number of viable pharmacologic therapies available. Drugs that predominantly affect slow pathway conduction include digitalis, calcium channel blockers, and beta-blockers. Drugs that predominantly prolong refractoriness, or time before a heart cell can be activated, produce conduction block in either the fast pathway or in accessory AV connections including the class IA antiarrhythmic agents (quinidine, procainimide, and disopyrimide) or class IC drugs (flecainide and propafenone). The class III antiarrhythmic agents (sotolol or amiodorone) prolong refractoriness and delay or block conduction over fast or slow pathways as well as in accessory AV connections. Temporary blockade of slow pathway conduction is usually achieved by intravenous administration of adenosine or verapamil. [Scheinman, Melvin: Supraventricular Tachycardia: Drug Therapy Versus Catheter Ablation, Clinical Cardiology Vol. 17, Supp. II-11-II-15 (1994)]. Other agents such as encainide, diltiazem, and nickel chloride are also available.
As in FIGS. 2, 3, and 4, the drugs may be placed on the stent 1 in a drug eluting coating 8. The drug eluting coating may be placed uniformly over the outer wall of the stent as in FIG. 2 or they may be placed in a narrow circumferential band on the proximal end of the stent as in FIG. 3. This band creates a short longitudinal segment of the stent which is capable of eluting drugs into the surrounding pulmonary vein. The remaining longitudinal segment of the stent is not covered with a drug-eluting compound. The stent is placed into the target pulmonary vein 4 such that the drug-eluting band is on the end of the stent nearest the left atrium after placement, as in FIG. 5.
As shown in FIG. 4, the drugs may be placed uniformly over or within the entire stent, while only a small band 9 is permitted to elute drugs outward into the pulmonary vein wall. This is accomplished by having a coating 10 covering a substantial longitudinal portion of the stent which prevents elution of the drug, thus leaving a small circumferential band which allows elution of the drug into the target pulmonary vein. The coating impedes the elution of drugs from the portion of the stent which is covers. This coating may be a thin layer of polyurethane or any other biocompatible coating impervious to the drug to be eluted. Having a small region 9 through which the drugs are eluted increases the ratio of drug volume to elution surface area. In other words, the large amount of drug-eluting compound can only be eluted through the small surface area, thus, increasing the ratio of drug volume to elution surface area. Where the stent is made of a polymer or hydrogel, the entire stent material may be loaded with the eluting drug.
The methods and devices described above can be accomplished with many embodiments of stents. Additionally, many stent materials and drug compounds may be substituted for the materials and drugs described. Thus, while the preferred embodiments of the devices and methods have been described in reference to the environment in which they were developed, they are merely illustrative of the principles of the inventions. Other embodiments and configurations may be devised without departing from the spirit of the inventions and the scope of the appended claims.
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Updated: 08/24/2014 8:40 PM
Created: 08/14/2014 4:14 PM KSTP.com
By: Lauren Beukelman
The Third Street flyover ramp from northbound Interstate 35W in Minneapolis will be closed from Aug. 25 to Sept. 15.
The road will be closed during the reconstruction of Fourth Street South, which includes the addition of turn lanes for a new northbound I-35W entrance ramp.
Motorists will be detoured to westbound Washington Avenue and southbound Chicago Avenue.
The reconstruction is part of the larger I-35W project that aims to improve traffic flow, reduce travel times and costs for motorists.


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Building a 1981 Yamaha YZ465 Factory Replica...
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Two Wheel Addict
Joined: Sep 2006
Location: Spokane WA
Oddometer: 2,048
I am enjoying your thread--and learning quite a bit. I have two '81 IT465s I am combining into one. I have a new top end--piston and freshly bored matched cylinder. I also have some new wiring, new bearings everywhere, new DG exhaust system, new bars, new tires, new cables, new brakes. In short, a nice project ready to put together and try out.
My biggest dilemma with the IT465 is that neither of my cases will work without some repair and maybe machining. The better of the cases has a hole between the tranny and the crankcase.The other case is shattered at the kickstarter shaft (lots of abuse there from energetic POs, I fear). I recognize some of the flaws in your cases as similar to my own,
Your photos and research have shown me my cases are about par for the course and not unusually damaged. I am also learning what to look for as I put everything back together.
My best course of action, though, might be to purchase a set of cases in good condition and bin what I have. I have plenty of tranny gears in good shape so even a worn out gearbox won't be a deal breaker for me.
Thank you for taking the time to document your YZ project
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Reports: Former Dodgers P Kuroda To Return To Japan
panese media report free-agent right-hander Hiroki Kuroda will return to Japan in 2015 to pitch for his first team, the Hiroshima Toyo Carp.
Keidel: Giving Thanks For Sports
Since we are upon our great day of gratitude, a pretext for gorging on poultry and then taking our swollen torsos to the nearest television for some football, let's look to sports for reasons to give thanks.
6 Most Overpaid Athletes
Because we think that extra million is just one too many.
5 Things You May Have Missed: Cliff Lee Farts On Camera, A-Rod 'Mocumentary' And Jack White At Wrigley
From Cliff Lee breaking wind off the mound to a Browns fan relieving himself on Art Modell's grave, here are the five stories you may have missed this week.
12 Types Of People You See At A Baseball Game
Have you ever really looked around at the types of people in the crowd during a baseball game? Well, maybe now you will.
Murphy, Betances Lead Yankees Over Angels
John Ryan Murphy spent a while in the minors catching Dellin Betances, hoping they could someday contribute on a higher level.
Bronze Statue Honoring Late-MLB Player Cory Lidle Vandalized
Authorities Friday were searching for a vandal they say caused an estimated $100,000 in damage to a bronze statue honoring the late-MLB player Cory Lidle.
Gallo Goes There: Don't Like New York? Why You Need Their Teams To Be Great
Okay, whoa. Whoa whoa whoa. Where are you going? Don't leave. Not rooting for them more than your own favorite teams. That's not what I mean. Not even rooting for them to win championships. But rooting for them to be good. Rooting for them to be legitimate contenders.
Keidel: New York, The Worst Sports Town In America
Local cable providers love to remind us that we have nine – yes, nine – professional sports clubs, a way of persuading us to click on this package or that so we can view the screen-in-screen horror we call baseball, football, and basketball.
TTYM: Blackhawks Fan Steals Adam Pardy's Helmet & Artie Lange Slams A-Rod
by @TaraLipinskyMore Columns here. In this week's That Thing You Missed, comedian Artie Lange bonds with the BoSox, the World Series champs clear up a hairy situation and hockey fans are as tough as the players. Blackhawks […]
Keidel: All Eyes On A-Rod And Home Debut At Yankee Stadium Tonight
The eyes of America are indeed on the Bronx these days where a certain slugger will make his home debut tonight at Yankee Stadium.
Kobe At Dodgers-Yankees Game: Walking Stairs With No Limp, All Positive Signs
Wednesday night, Kobe Bryant used his influence with owner Magic Johnson to nab dugout seats, and talked to CBS2/KCAL9 Jim Hill on how his achilles rehab is coming.
Yankees Spoil Mattingly's Return To NY With 6-4 Victory Over Dodgers
Yankees fans showed Don Mattingly the love from the moment he took the lineup card to home plate Wednesday. Hiroki Kuroda, though, wasn't feeling nostalgic when facing his old team.
Angels' CJ Wilson Limits Yankees To 2 Runs In Win
C.J. Wilson outdid Andy Pettitte with seven effective innings, Albert Pujols and Mark Trumbo each had three hits and Chris Iannetta singled home the go-ahead run, leading the Los Angeles Angels to a 5-2 victory over the New York Yankees on Friday night.
Dodgers Take On Yankees In Their 1st Old-Timer's Game Since 1995
The Los Angeles Dodgers will host their first Old-Timer's game since 1995 Saturday evening at Dodgers Stadium.


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Gnarly Adventurer
Joined: Jun 2008
Location: B.C.
Oddometer: 112
Hey Ridge,
1. High speed slab - for most of the trip I was carrying a fair bit of luggage, sometimes a spare tire as well, so cross winds and trucks had a lot of weight to push around in addition to the bike weight of 197kg (sans fuel). In Patagonia, it wasn't slab but on the highway the winds are notorious for absolutely howling, gusts of 30, 50, and 70 km/h are not uncommon. It tracks well, feels very positive, but you will be more upright and higher with the 21" configuration than more street orientated bikes so will catch more wind. Not noticeable in most cases though, but you will notice that it would feel more at home and positive than your KLR on the freeway. A loose analogy is that KLR feels like a middleweight, the 800 like it's in between a middleweight and a heavyweight (welterweight?).
2. Handling - your conclusions certainly make sense to me, at slow speeds the stroms do feel like they might topple. Your skills get good though, almost like a mountain biker balancing at a stop light, and then you try a bike with standard off road set up and the difference is quite significant. Flickable is a word that describes it alright, but in reality it is more than just that. However, it is a bit more bike to move around at slow speeds so the tradeoff of it feeling more at home on the highway than the KLR is that it feels a tad more cumbersome when doing the stop and start, slow speed conditions that you describe. Not significant though.
Side note, the 800 in reality is not that much lighter than the 1200, I have heard a couple of people state that they actually prefer the bigger bike offroad but IMHO that is a function of what you are used and not reflective of what the vast majority of people would feel. In the vast majority of cases, lighter is better.
And to quickly comment, I would certainly expect a very broad range of experiences to come from the many different riders that will be buying this bike. This is just my opinion and based on my experience. It is a bit unusual because you get to ride almost every single day when touring and therefore things that you notice, other's wouldn't under more standard riding conditions and vice versa, things that one person ignores are very noticeable to the once a week or once a month rider.
Hope that helps:)
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Whitewashed blocs clinging to the rock above Elia Beach, offer stunning views down over the sea and distant islands. This 'place of perfection', with its traditional architecture, modern materials, original artwork and contemporary furniture, invites you to enjoy the best that Mykonos has to offer: watersports on the private beach, lounging beside the infinity pool, which appears as if suspended over the sea, or relaxation on the terrace. All hotel guest rooms boast stunning sea views. And a regular shuttle to the picturesque port of Mykonos offers you the opportunity to enjoy island life. ...Read more
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Posts tagged 'Focus on Product'
Dec 31
Jan 2
A T9er Fumbles Around India: Joyful, Overwhelmed, but Well-Outfitted
Our retail gal, Kate Johnson, from the Madison store recently traveled to India and brought back with her some excellent fashion advice, a fresh take on the less popular Kerala, and a beautiful reflection on the women of the world. Enjoy.
Traveling to India is one of those once in a lifetime opportunities. When the chance arises, you just have to emphatically say YES and ask questions later, sure that the details will work themselves out- as they always do. In July, my husband and I spent two weeks in the South Indian state of Kerala. Contrary to what Kerala's tourism board would lead you to believe, this is not the typical American tourist choice. Most opt, understandably, for the Taj Mahal, Delhi, Mumbai or Varanasi, all in the north. We were also traveling during monsoon season- euphemistically known as 'the off-season'. Needless to say, packing was daunting. Luckily, I work at a Title Nine store!
So, here's what I ended up bringing with me: mostly SAMBA. I tell you what; I'm not sure what I would've done without my Samba V-Tees (long and short sleeved of course). Well, actually I can tell you exactly what I would've done – there would be plenty of photographic evidence of a beet red, sweaty, frizzy-haired, soaking wet, smelly, smelly white girl in India. Instead, thanks to Title Nine, I maintained a reasonable body temperature (and moisture level, for that matter) and was free to explore and enjoy my surroundings. Culturally, shoulders should be covered at all times and any obvious 'chest' should be concealed. But the hot and humid weather disagreed. The tencel blended with cotton and spandex of the Samba fabric performed above expectations. It resisted odor like a champ, wrinkles shook out like an instant face-life, and breathed like… Lance Armstrong. If I had been thinking straight, I would've packed my Samba dress (Amelia) and skirts (Amelia and Cha Cha)! Burnouts from Prana proved invaluable as light, breathable layers and cover-ups. Here's the Chai Tee in action at a spice market in Koch:
T9er's Holiday Wish List
As Title Niners, we too have our wish lists for the coming holiday! Lucky to be around such great product day in and day out, it's not hard to have a million things we'd love, but below are some of the teams top picks. We wanted to share with you in hopes of providing a guide if you are shopping for someone but don't know what to get! Picking different gals with different tastes, hopefully you can find someone similar to the girl you are shopping for. Also, stay tuned for more ideas – we have a few more Title Niners on the way!
Whenever you are ready to shop, go ahead and click any of the items of clothes, or you can always (and we would love to meet you!) hop on into one of our retail stores (Salt Lake City is now open!), or give us a buzz here at the office. Happy Shopping!
T9 Vocabulary Lesson: Regulator and Woolicious
We love product reviews as much as you do. And we thought it's high time to take the conversations had over mixing our oatmeal here in the kitchen, zooming around on scooters, and waiting for the next workout and put them down on "paper" for you. Rebecca, our Director of Retail, is always waiting for next years Regulator, and Alice, of Alice's Picks, is lovin' the Woolicious this year. Here's their take.
Take it, or leave it 😉
Oct 16
Butter Button-Up Review
My hands down favorite fabric for pretty much any activity is our "Butter" products (by Mountain Hardwear). I doubt I could do the fabric justice by trying to put into words how incredibly soft it is -


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TV Info
Episode PremiereApril 14, 2010
Show Period2010 - 2010
Production CompanyGlassman Media
Cast and Crew
Main Cast
- Tinsley Mortimer
- Dabney Mercer
- Dale Mercer
- Alexandra Osipow
- Jules Kirby
- Paul Johnson Calderon
Tinsley's rival Devorah Rose throws a party for the launch of her new bikini line, and drinks and tempers fly when an uninvited Jules arrives. Paul reconnects with Tommy. Tinsley reacts to Devorah's interview in NY Magazine.


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Sports Illustrated has released their most popular issue in honor of man's favorite sport—gawking at women in swimsuits. And this year's Sports Illustrated model? Kate Upton.
The 19 year-old model is wowing the industry with her 33-25-36 physique (so not 36-24-36? Woah, what an ug), and she became on overnight sex symbol after the Sports Illustrated Swimsuit Edition was released.
But Kate first gained notoriety after she posted a video of herself doing the Dougie, and it went viral. You remember the Dougie. It came after the Soulja Boy but before the Bernie?
Anyway, I'm giving away too much. Here are 5 things you might not know about the latest Sports Illustrated model, Kate Upton.
She rides horses: Kate has competed in several horse riding competitions. And if her looks and success weren't enough to make you jealous, the woman has a freakin' pony. Its name is Roanie Pony.
She's kissed Kanye: Kate was photographed kissing Kanye West on the balcony of his Cannes hotel May of last year. Now, she's currently reported to be dating NFL star Mark Sanchez.
She can handle a ball: A softball. I know what you were thinking, pervert. Upton competed in a Taco Bell All-Star Legends & Celebrity Softball game at Chase Field last year.
She's the youngest SI cover girl in recent history: Kate's only 19 years-old and has been modeling since the age of 15. She's modeled for Guess, Dooney & Bourke and Victoria's Secret.
She's been on Tosh.0: So we know she's either got a sense of humor or loves a man in a cardigan. Kate appeared on a June 2011 episode of comedian Daniel Tosh's show, participating in a segment called 'Knife or Banana.' She gets stabbed with a banana.
Check out Kate doing the dougie below:


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1967 Chevrolet Caprice, This car is cherry. original paint and very clean. Very hard to find a better example in this shape. It does... More
CHEVROLET: 1967 Caprice Classic 4-door hardtop, third owner, originally 427/385 hp (now fresh 454), a/c, pw, ps, pb, tilt wood steering wheel, AM/FM stereo,... More


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Campaigns blog
Campaigns blog
We believe that all children deserve a good childhood. That's why we campaign for the most vulnerable children and young people who face poverty and neglect, fighting injustice and protecting them from harm.
16 and 17 year olds are caught between childhood and adulthood
Our new Seriously Awkward campaign calls for better protection for vulnerable 16-17 year olds. You may wonder what protections these teenagers need.
Luke's story: Something isn't quite right
The most vulnerable 16 and 17 year olds are falling through the cracks between childhood and adulthood, simply because of their age. Our Seriously Awkward campaign aims to change that.
New guidance won't protect children from payday loan adverts
Thousands of you joined us in saying payday loan adverts can trivialise the seriousness of taking out a loan, and we have a partial response from the advertising watchdog - plus other campaign news
The morning after the (election) night before
When the next Government comes to power, we will continue campaigning to protect young people at risk of abuse or neglect, and to end child poverty and social inequality.
Care leavers struggle with council tax debts
'Every day, my work shows me how important it is to raise awareness of the challenges care leavers face as they leave the care system, particularly with money and avoiding debt.'
Who's afraid of the big bad wolf?
Not you guys, apparently. However, clowns, stormy weather and er, nuns did make the list when we asked you to share what scares you in the lead up to the launch of our Debt Trap campaign.
2m children in poverty miss out on the warm home discount
Join us in telling the government to act to stop children from growing up in cold homes
Use our map to find your local welfare assistance scheme
Search by postcode to find your local authority's scheme to replace community care grants and crisis loans for general living expenses
By the numbers: Young people's well-being
What are some of the key figures in The Good Childhood Report 2013, our new report on the well-being of young people in the UK?
An interactive look at young carers' lives
While census data reveals a spike in the number of young carers our report highlights the families young people behind the numbers
Christingle - Inspiring a new generation
Hear the heartwarming story of how Christingle is being passed on from generation to generation at St Mary's Church in Market Drayton.
Infographic: What dangers do young runaways like Susie face?
Your donation can help these vulnerable children


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Hundreds of Vulnerable Communities Not Tsunami Ready
Proposed NOAA Cuts Would Reduce Ranks of U.S. Cities Prepared for Tsunamis
Published on Jun 11, 2012 - 7:22:32 AM
By: Public Employees for Environmental Responsibility (PEER)
Washington, DC June 11, 2012 — Less than one in seven at-risk American communities is "adequately prepared for a tsunami," according to federal estimates obtained by Public Employees for Environmental Responsibility (PEER). Yet the National Oceanic & Atmospheric Administration is proposing to end its support for state and local tsunami readiness despite admitting that this move will significantly reduce the number of communities which will be ready to quickly evacuate and take other steps to minimize tsunami impacts.
During the past decade, tsunamis have killed more people than almost every other natural hazard. Since 1900, more than 100 tsunamis have hit Pacific U.S. states and territories, killing nearly 400 people.
NOAA documents produced under the Freedom of Information Act state that it counts 767 "tsunami at-risk communities in the U.S" with California having the most (158), followed by Maine (105), Alaska (75), Washington (52) and Oregon (50). However, NOAA currently classifies only 100 communities as "TsunamiReady," a status denoting sufficient measures in place, such as evacuation plans, emergency operations support, sirens, signage, etc., to mitigate tsunami losses. At the present rate of NOAA funding, eight more communities each year are expected to become TsunamiReady.
Buried within its FY 2013 budget submission to Congress, the agency proposes a cut that "terminates NOAA partnership funding for education and awareness programs to the National Tsunami Hazard Mitigation Program (NTHMP)." NOAA further estimates that this $4 million reduction will slash the growth rate in TsunamiReady communities by more than half, meaning that by 2017 an estimated 25 fewer communities will be tsunami ready than if NOAA continued the program.
"We have only made a dent in preparing our at-risk communities for minimizing tsunami impacts. Instead of doing more, NOAA is retreating," stated PEER Executive Director Jeff Ruch. "This makes as much sense as eliminating school fire drills to reduce overhead."
The 2011 white paper by the Western States Seismic Policy Council, an earthquake consortium funded by the Federal Emergency Management Agency and the U.S. Geological Survey, found that "tsunami mitigation and preparedness require maintaining partnerships and funding… through NTHMP." The Council elaborated on the value of these state and local programs:
"Federal Tsunami Warning Centers cannot provide timely tsunami alert messages to communities located nearby subduction zones, like Cascadia and the Aleutians….This was demonstrated by the September 28, 2009 tsunami which devastated low-lying coastal areas of American Samoa…. Although 34 people were killed, if it were not for tsunami education efforts…the casualties from this tsunami would have been more than ten times more. Support by the NTHMP and other agencies saved countless lives during this and other recent events."
"This small investment in local tsunami readiness saves lives and is one of the most cost effective things NOAA does," added Ruch, noting that the overall NOAA budget is slated to increase by more than $150 million under the President's FY 2013 plan. "NOAA says that it will take over public tsunami education but that is a function for which the federal government is especially unsuited."
While both houses of Congress have balked at the proposed elimination of NTHMP as well as NOAA's plan to cut back on tsunami monitoring buoys, the agency's budget has been thrown into chaos by previously unreported fiscal shortfalls in the National Weather Service. NOAA is now threatening to furlough employees if Congress does not immediately approve the re-programming of millions of dollars. As a result, the ultimate mix of NOAA funding for the coming year remains murky.
See NOAA estimates of tsunami vulnerability
Look at current tsunami-ready communities
View the termination notice for NTHMP
Read the WSSPC white paper
Examine other proposed NOAA tsunami cuts
Revisit the fiscal mess inside NOAA
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text:
HSBC "lift" by Grey London
Agency: Grey London
Rating: 5.0
campaignlive.co.uk, Monday, 05 October 2009 09:15AM
Find out in our video above.
View the original ad and give your verdict: Patak's 'Patak' by JWT London
Video produced by Vox Pops International on behalf of Campaign.
Watch more Public View videos
This article was first published on campaignlive.co.uk
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Agency: Grey London
Rating: 5.0


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IT has been called the "emotional" bid for Rangers, one that binds the passions of the fans to their 140-year-old football club.
The Blue Knights group led by ex-Rangers director Paul Murray was "surprised and disappointed" after losing out on the preferred bidder status.
RANGERS fans last night claimed they don't know enough about Bill Miller despite his grand promises.
RANGERS' players have been advised that they can leave the club for free if it becomes a "newco" despite administrators Duff & Phelps telling them their contracts would transfer automatically.
AMERICAN tycoon Bill Miller has pledged to banish the "travesty" of Craig Whyte's era after winning the race to be named the preferred bidder for crisis-hit Rangers.


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Originally written on Fox Sports | Last updated 5/25/13
Angel Pagan hit an inside-the-park homer with a runner aboard in the bottom of the 10th inning to give the San Francisco Giants a 6-5 victory over the Colorado Rockies on Saturday. Troy Tulowitzki led off the 10th with his 10th home run to put the Rockies ahead 5-4. Colorado closer Rafael Betancourt (1-2) walked Brandon Crawford to open the bottom half. Guillermo Quiroz sacrificed before Pagan sent a drive that bounced at the base of the right-center fence and got away from Michael Cuddyer. The speedy Pagan raced around the bases and slid home well ahead of the tag. It was Betancourt's first blown save in 11 chances this season. Carlos Gonzalez homered among his three hits and drove in two runs for the Rockies. Cuddyer and Jordan Pacheco also drove in runs. Buster Posey had three hits and scored twice for the Giants, who ended a four-game slide against the Rockies. Hunter Pence, Andres Torres and Marco Scutaro each drove in runs. Crawford and Pablo Sandoval had two hits apiece...
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text: This is an ok hotel for a night if traveling to Santiago de Cuba or Baracoa and want to spend the night at Guantanamo city. It is not in a central location but has a nice sized pool and the breakfast a la carte is included with some hot items. Not a great hotel, but again for a night you... More


text:
Shortly after my "How do we get the SBS Software Assurance benefits such as: Outlook 2007, Entourage 2008, ISA 2006 + additional Windows Server 2003, and Office SharePoint Designer 2007 now that SBS 2008 is out?, post went live, I received a follow-up question that said, "Can you make it clear of what part numbers we need to specifically ask for and what fees we will pay? I've had several reports of people calling that number and it's not clear for those trying to get these benefits."
Well, I've reached out to the various teams and am happy to share with you the chart of part numbers you will need to order the media kits for those specific SA benefits you are eligible for if you had SBS 2003 with Software Assurance (Premium in some cases, so see earlier post above for what you are eligible for). Here are those part #s:
Standard shipping and handling rates are $5.99 for the US and $9.99 for Canada for the media kits.
Thank you and have a wonderful day,
Eric Ligman Global Partner Experience Lead Microsoft Worldwide Partner Group This posting is provided "AS IS" with no warranties, and confers no rights
Last Thursday at our monthly Puget Sound Small Business Server User Group ( www.pssbs.org ) we had the


text:
Wilson, J; (2009) Not so special after all? Daniels and the social determinants of health. Journal of Medical Ethics , 35 (1) 3 - 6. 10.1136/jme.2008.024406.
|PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Just health: meeting health needs fairly is an ambitious book, in which Norman Daniels attempts to bring together in a single framework all his work on health and justice from the past 25 years. One major aim is to reconcile his earlier work on the special moral importance of healthcare with his later work on the social determinants of health. In his earlier work, Daniels argued that healthcare is of special moral importance because it protects opportunity. In this later work, Daniels argues that the social determinants of health ( which in fact tend to have a larger effect on health outcomes than healthcare does) should also be considered special. This paper argues that it is a mistake to base a theory of justice for health on the claim that health ( or the social determinants of health) are "special'', for three reasons. First, once we realise that health is to a large part socially determined by features such as distribution of income, which are also of independent importance for justice, we cannot talk about a theory of justice for health in isolation from an overall theory of justice. Second, when we are trying to work out the place of health in a general theory of justice, being told that health ( or the social determinants of health) is special is unhelpful. The relevant starting point should rather be whether health matters in a fundamental way for justice, or whether it matters merely for the effects it has on those goods which are of fundamental importance for justice. Third, treating the social determinants of health as special would in fact be counterproductive in terms of the broad approach to justice Daniels favours.
|Not so special after all? Daniels and the social determinants of health
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|UCL > School of Arts and Social Sciences > Faculty of Arts and Humanities > Philosophy
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Former MP, Bradford East
See full list of topics voted on
New: more analysis of votes on health, welfare, foreign policy, social issues, taxation and more.
David Ward quite often rebelled against their party in their last parliament
To ask the Secretary of State for Business, Innovation and Skills, whether there has been a reduction in Bradford College's budget for Level 2 and Level 3 courses.
To ask the Secretary of State for Business, Innovation and Skills, if his Department will take steps to ensure that courses are not cut at Bradford College owing to reductions in its budget.
Is the Deputy Prime Minister as disappointed as I am that the groundbreaking devolution deal announced for West Yorkshire received a less than generous response from certain West Yorkshire council leaders?
More of David Ward's recent appearancesRSS feed (?)
Former Liberal Democrat MP for Bradford East
Entered the House of Commons on 6 May 2010 — General election
Left the House of Commons on 30 March 2015 — General election
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Last updated: 30 Mar 2015.
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This data was produced by TheyWorkForYou from a variety of sources. Voting information from Public Whip.


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Designed to fit a 10'' skillet, this lid gives you a snug fit. The glass lid will allow you to watch your food without lifting the lid.
Material: Glass
Dimensions: 3.1 " H
Weight: 1.4 Lb.
Care and Cleaning: Dishwasher-safe
other Info.
- Online Item #: 11044804
- Store Item Number (DPCI): 070-01-0180
- Imported


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In January 1990, International Medical Group®, Inc. (IMG®) opened its doors in Indianapolis, Indiana, as a managing general underwriter, marketing and administrative company offering health, life, travel and indemnity insurance to the international community. Our philosophy was to provide agent-friendly products that were simply underwritten and supported by high administrative standards. After 22 years this philosophy remains intact.
IMG has established an international reputation for excellence by providing medical and related international insurance products to individuals, families and groups in more than 170 countries. We have developed an extensive product portfolio that allows us to reach several different targets in the international market, and that has enabled us to serve over a million clients worldwide including vacationers, business executives, missionary groups, entertainers, Fortune 500 companies, schools and universities, professional marine crew, expatriates and local and third country nationals.
We have set a higher industry standard by integrating independent credentialing services with in-house, fully owned and operated service divisions. These accreditations promote continous improvement in quality and efficiency while ensuring ongoing compliance. Through our family of companies, we provide around-the-clock medical management services, trip cancellation programs to help protect travel investments, stop loss insurance designed to reduce employer risk and international service and assistance centers to ensure we are available when and where needed.
A Global Organization - Our multilingual staff of seasoned professionals is available to provide expert advice and insight into several different markets. As subject matter specialists, we are at your disposal. We are pleased to provide you with quotes, contributions to articles, essays, and feature stories; general commentary, or articles of interest for your publication.
Areas of Expertise
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International Medical Group, Inc. All rights reserved.


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YIELD: Makes about 2 1/2 cups
Preheat oven to 300°F. Place pecans in medium bowl. Melt butter in heavy small saucepan. Add cumin and cayenne and stir until aromatic, about 15 seconds. Pour over pecans. Add sugar and salt and stir to coat. Transfer to baking pan. Bake until nuts are toasted, stirring occasionally, about 20 minutes. Serve warm or at room temperature. (Pecans can be prepared 5 days ahead. Store in airtight container.)


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Woman arrested in fundraising fraud in Phoenix
Her bond was set Thursday at $25,000. Pacheco doesn't have an attorney yet.
Pacheco allegedly paid teens to sell the fraudulent coupons in the name of the organization Students Against Destructive Decisions.
Police said the coupon offers weren't authorized by the companies displayed.
The scheme unraveled when a teen tried to sell the fraudulent items to SADD's Arizona director.
Police said Pacheco was found in possession of more than 80 coupon books that displayed the SADD trademarked name and logo.


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Vault Collection| WB Archive
Untamed DVD
Price: $17.99
- Technical Specs
- Format: DVD [MOD]
- Rating: Not Rated
- Run Time: 86 Minutes
- Region: 1
- Aspect Ratio: Fullscreen
- Studio: Warner Archives
- DVD Release Date: March 22, 2012
- Audio: ENGLISH: Mono
**Please be aware that this is a manufactured on demand disc that was created using a DVD-R disc. It should play in all standard DVD players.
Additional Details
- DirectorJack Conway
- Primary CastJoan Crawford Robert Montgomery Ernest Torrence
- GenreDrama
- Release Date1929


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The back story on this was my daughter bought me a DOH Charger for my birthday.
She HATES pink so as a joke, I told here I was going to build her a Pink car soooo:
Blown aftermarket hemi, scratchbuilt plumbing for the blower hat, aftermarket MSD magneto, shaved emblems/door handles/drip rails, front valence and grill blended into body, rear valence scratchbuilt and blended into body along wth rear bumper, will have bigger radiator, aluminum aftermarket Weld big & little (not decided on tires yet), some custom decals/lettering, etc.
I will list sources for the aftermarket stuff once I finsh the car.
I welcome comments and criticisms.
Pink WIP 1.jpg 142.21KB
26 downloads
Pink WIP 2.jpg 72.37KB
27 downloads
1/16th Pink Street Charger WIP
Started by Bonekrosha, Nov 10 2012 12:34 AM
2 replies to this topic
Posted 10 November 2012 - 12:34 AM
Posted 10 November 2012 - 12:48 AM
Nice work on all 3 of the 1/16ths. My daughter just bought a Karmen Ghia kit she wants me to do for her, and she does want it Pink.
Posted 10 November 2012 - 01:00 AM
Thanks for looking.
Yeah, mine really hates Pink, anything pink.
I like those Kharman Ghias. Put a big block in it for her
Yeah, mine really hates Pink, anything pink.
I like those Kharman Ghias. Put a big block in it for her


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Classics movie directed by Edmund Goulding
Bette Davis won her second Best Actress Oscar for her showcase role in this sumptuous southern costume melodrama, which was released in 1938 in response to the phenomenal popularity of Margaret Mitchell's novelGone with the Wind. (It would take another … see full wiki
When Bette Davis missed out on the role of Scarlett O'Hara in GONE WITH THE WIND, Warners fashioned their own Southern drama for her, based on the play by Owen Davis. JEZEBEL was released a year before GONE WITH THE WIND. Both films feature musical scores written by Max Steiner.
The story concerns willfull Southern belle Julie Marston (Bette Davis) who is engaged to the handsome but conservative Pres Dillard (Henry Fonda). In order to get some life out of her passive finance, Julie decides to wear a dramatic red dress to the annual Ball (when every girl will be wearing traditional white). After her shocking entrance at the ball, Pres insults her by whirling her around and around the dancefloor, until she is the scandal of all New Orleans. The following day, the engagement is called off and the shattered Julie doesn't hear from Pres for a whole year.
When Pres does return, its revealed that he has married a beautiful "Yankee" society belle named Amy (Margaret Lindsay). The repentent yet vengeful Julie tries to steal Pres for herself again, but when the dreaded Yellow Fever epidemic strikes, tragedy does as well...
The cast also includes George Brent (42nd STREET), Donald Crisp (POLLYANNA, NATIONAL VELVET), Richard Cromwell, Henry O'Neill, Spring Byington and John Litel.
The DVD includes the trailer. (Single-sided, single-layer disc).
What did you think of this review?
Classics movie directed by Edmund Goulding
Classics movie directed by John Huston
Classics movie directed by Edmund Goulding


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It's places like the Peking Yard Hostel that are leading the hostel revolution. Say no to squeaky bunk-beds, say no to falling apart bathroom tiles, say no to threadbare sheets.
Peking Yard looks more like a boutique hotel than a youth hostel, with its flower-covered rooftop, brightly painted bedroom walls, squishy couches and gorgeous timber dining tables.
You can stay in a 10-bed dorm from about $15 per night, or if you want to get swanky, the deluxe double rooms (which have a private bathroom) are just $44 per night.
Plus, every day they take a hiking tour from Jinshanling to the Simatai section of the Great Wall of China.
(Warning: they use Comic Sans on their website, but don't let that put you off!)


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HSBC "lift" by Grey London
Agency: Grey London
Rating: 5.0
By Nick Batten, mediaweek.co.uk, Friday, 16 March 2012 10:59AM
As part of the deal, announced on 15 March, CNBC will have branding on the sides of the new Marussia F1 team race car, as well as on the drivers race suits and in trackside environments. It extends a partnership first brokered last year.
CNBC will broadcast regular on-air and online F1 news updates throughout the season and their first appearance on the side of the new race car will be at the Australian Grand Prix on 18 March.
Andy Webb, chief executive officer of the Marussia F1 team, said: "Last year our partnership proved successful, promoting the team to CNBC's influential audience and helping to expand and add value to our portfolio of commercial partners."
He added that the Marussia team are optimistic that they will be able to make a good step forwards this year and really start to build on their "ambitious plans for the future."
Founded in 2009, Marussia is an Anglo-Russian team based at the new Marussia Technical Centre in Banbury, UK. It is majority-owned by Marussia, the Russian supercar marque from Moscow.
One of the team's founding partners was Sir Richard Branson's Virgin group of companies.
Meanwhile, Santander has been named as the official 2012 broadcast sponsor of Formula 1 on Sky Sports.
The sponsorship, brokered by Carat and Sky Media, will feature Santander branding on opening and closing sequences, break bumpers either side of advert breaks plus on-air promos, online inventory and multi-platform coverage.
The sponsorship covers integrated material on all relevant skysports.com F1 TM specific sites.
Santander is also a corporate partner of Vodafone McLaren Mercedes and sponsor of Scuderia Ferrari, as well as title sponsors of several Grand Prix races throughout the season.
This article was first published on mediaweek.co.uk
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Agency: Grey London
Rating: 5.0


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Tuesday night my 17 month old dd took sick. She napped late and woke up at 7:30pm with a temperature. She was not sick at all prior and was her healthy self. At first, I thought she just got hot from having the blanket over her. All my kids are hot boxes. Just when we were getting the thermometer she started to have her seizures. It just seemed back to back. She was not looking at any of us and would just stare at the ceiling/light. I called 911 and they told us to go to one of those smaller emergency places since I am not that fond of the hospital she was born at. When the EMS got there her temperature was 102.8.
Anyway, they seemed like they were nervous at that facility, too. They took her blood, inserted the IV, checked her vitals, and the doctor said he wanted her to be further investigated at MUSC hospital. So, she was transported there. They really did not check her. They just read the results from her bloodwork. They said a virus was in her bloodstream and that there are too many types to tell what kind. They downplayed it by saying that we probably had it happen to us as a child (we did not). At 4am, she woke up with a 103.1 temperature.
The pediatrician said the same thing that the ER did about the spike of temperature causing the seizure. She said that she was higher risk for them now due to her history. It can happen again since it already did. This virus has no cold symptoms other than the fever. She is not having any wet diapers really and is barely drinking. She is just fighting something that I cannot see or do anything about. Somehow, the doctors just leave me with this and its all on me from here on. There has to be a rash, color change, or another seizure in order for it to be worthy of doing something about.


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Gear Review
Best 15 Degree Sleeping Bag in my opinion, and here's why!
I have been a backpacker over 25+ years. I finally decided to purchase THE BEST 3 season sleeping bag on the market, bar none. After reading numerous articles and reviews, I narrowed it down to 3 finalists: Montbell UL Super Spiral Down Hugger #1, Marmot Helium 15, and the Mountain Hardwear Phantom 15.
Being a Backpacker Magazine subscriber for over 5 years(Excellent magazine) I was leaning towards the Marmot which has won the Backpacker Magazine Editor's Award. But then I found an excellent website which changed my mind: www.outdoorgearlab.com. It showed some of the most detailed reviews I've ever seen, and they are absolutely correct! Marmot has no neck baffle, which does not insulate the body from the cold air coming into the body area from the face opening. Also it has an unusually wide torso area which is good if you are a big stocky guy, but otherwise it is inefficient if you have athletic slender or medium sized body (I am 5'11" 155Lbs). Montbell is also excellent bag, but the hood design is pretty poor and I really dont' care about their stretching ability. It also adds few more ounces.
Finally there is one more bag out there, the most expensive Marmot Plasma 15 which costs $470, but it's way out of my price range.
So there it is, my final verdict is MH Phantom 15. And I love this bag! Backpacker Magazine just proved that they are not always right! :)
HAHA backpacker magazine is rarely right. Every piece of gear that they have recommended and i've bought i ended up returning or junking!!!
View More Details on Mountain Hardwear Phantom Sleeping Bag: 15 Degree Down


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A Sample of Our Experts
Who We Are
Securities Experts Roundtable members provide expert consulting, testimony, and other services in securities litigation and FINRA and AAA arbitration. SER facilitates the sharing of ideas and information concerning issues common to members by conducting conferences, seminars, and meetings to provide continuing education and assisting members in improving their professional conduct, performance, practice, and expertise.
Our experts are widely used to provide insight in the analysis of investments, documents, securities law, as well as utilized in speaking engagements and training. SER was formed in 1993 and has a nationwide presence of individuals with a wide depth and breadth of knowledge in the securities industry.
To find an expert that fits your needs, use our "Find an Expert" search page. Use the contact information provided in each member's profile to contact that member directly. Our securities experts include expertise in supervision, suitability, margin, damages, options and portfolio analysis.
SER encourages the pro bono participation of our members in Legal Clinics, several of which are affiliated with law schools, by teaching, consulting, and providing expert testimonial services.
In addition, we support and improve the process of securities dispute resolution through participation in conferences, committees, and meetings of other organizations involved in the process of securities dispute resolution.
Select the link to see SER's position on:
The Securities Experts' Roundtable provides a password protected directory on this website for each member who wishes to provide contact information and a business profile. Individual SER members are responsible for all information contained on their personal profile. Some members have chosen to provide links to websites not maintained by SER. SER does not endorse any web sites, their sponsors, or any of the policies, activities, products, or services offered on the site or by any advertiser on the site.
|© Securities Experts Roundtable


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Add 3D life to 2D drawings; learn to render your designs with AutoCAD.
Learn to build curtain walls ranging from simple, preconfigured options to custom and free-form curtain walls with Revit.
Learn to build roofs with Revit: from flat roofs to crazy free-form roofs and everything in between (hip, gable, mansard, Dutch hip combination, and gambrel).
Learn how to use Navisworks Manage and Navisworks Simulate to gain control and get a holistic view of your building projects. Create virtual builds and walk-throughs of your models and anticipate outcomes before you begin.
Covers the process of creating a family and adding parameters, 3D elements, symbolic lines, and materials.
Practice designing stairs for commercial and residential buildings, as well as winding stairs, custom railings, and ramps.
"As a teacher, I respect the way that your tutorials are hands-on and interactive. They are quick and to-the-point, and the teachers you have chosen are patient and concise." —Joshua M.
more from our members »


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Originally written on Steelers Depot | Last updated 4/26/13
Following the 2013 NFL combine, Mel Kiper Jr. of ESPN, and several others for that matter, had Georgia linebacker Jarvis Jones atop their prospect rankings. These rankings were also released after Jones had been poked and prodded by every team doctor who wanted to check out his the spinal stenosis in Indianapolis. In a matter of two months time, Jones found himself still on the board come time for the Pittsburgh Steelers to select the 17th pick of the first round of the 2013 NFL draft. Here is what Kiper wrote about Jones in late February after deciding to sit out the combine. Jones still must Read more [...]
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about Todd FlowerdayA Roman Catholic lay person, married (since 1996), with one adopted child (since 2001). I serve in worship and spiritual life in a midwestern university parish.
about John Donaghy
John is a lay missionary since 2007 with a parish in western Honduras. Before that he served in campus ministry and social justice ministry in Iowa. His ministry blog is http://hermanojuancito.blogspot.com
He also blogs reflections on the lectionary and saints/heroes/events of the date at http://walktheway.wordpress.com
He'll be a long-term contributor here analyzing the Latin American bishops' document from their 2007 Aparecida Conference.
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- Dives in Misericordiae 7d: An Intimate Culmination
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- PS 97-98: Easter Day
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- Worthy Women: Gertrud Luckner
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Daily Archives: 5 June 2009
Lions, Tigers, and a Bear of a Trip
Back from the one-senator state. Huh. The trees and grass look as green, and the zoo animals appear well-fed. Life goes on. Have you ever had one of those little trips where everything is just on the edge of being … Continue reading
Posted in My Family, Other Places Leave a comment
Dialogue and "Humility in the Face of Transcendent Truth"
(This is Neil) What is necessary for theological dialogue? As yesterday's post suggested, there are three essential principles that Christians must accept. First, they must be convinced that they have received "good news" and must proclaim it to others. Second, … Continue reading
Posted in Neil Leave a comment