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14 July 2015
Where there's a Web, there's a way
Join us for a one-hour webinar to learn how you can simplify daily activities for your librarians. Hear how OCLC's cloud-based strategy will allow you to:
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WMS success story: Pritzker Military Museum & Library
Join this 30-minute webinar with guest presenter Theresa Embrey, Chief Librarian at the Pritzker Military Museum & Library. Theresa will share her library's experience with WorldShare Management Services (WMS). During this session, you will:
- Hear why the Pritzker Military Museum & Library chose to implement WMS
- Learn the ways WMS is streamlining work to save staff time
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Originally written on Fox Sports Southwest | Last updated 7/26/13
HOUSTON (AP) -- Linebacker Brian Cushing had never dealt with a major injury before and wasn't sure how he'd handle missing Houston's last 11 games after knee surgery last season. Exactly a week later, he found motivation when his son Cayden was born. When his rehabilitation got tough, his first thought was that he had to get better so his son could see him play. Cushing was back on the field for Houston's first day of training camp Friday and says he feels great. The Texans are taking it slow with Cushing, but they hope he returns as the player he was before the injury when he finished with 114 tackles and four sacks in
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Dakar Dazed - countdown to bankruptcy!
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JMo (& piglet)
Gone a bit Baja
Joined: Apr 2007
Location: Somewhere west of Laramie...
Oddometer: 4,444
Originally Posted by
Awesome stuff Jenny!!
I knew there had to be a good reason why you chose not to do the Sertoes. Be sure to check out my RR thread underway on the Dos Sertões for tips & hints on my WR.
Living the Dos Sertões Dream
I think I found a couple of problems with that nav tower, and also watch those fuel lines from the RH tank!
I got the JVO rear thank - its HUGE. Are you doing the same or are you making up some auxilary tanks separately?
What kit is Craig Bounds using? Hopefully the same. Looking forward to seeing your prep for this.
Hey Neil - yes I've already been tucking into your report from Brazil, but will study it carefully!
As you say, it really wasn't feasible to do Dos Sertoes (and also Pharaoh's which I've had to forfeit this year) and Dakar in January... my bike is still essentially 'as new' after Tunisia (ok, so maybe I should have tried a bit harder eh?), so is ideal to take to the Dakar this year... it would be a lot more secondhand after another FIM round or two I imagine!
I'd hoped to have the bike back last weekend and some tasty photos/info for you all, but there is a slight delay on getting my tanks made - rather than go the route Neil did with the full JVO kit (beautiful as it is, and in an ideal world money wise etc etc), I have elected to try a bit of 'mass centralization' on the WR, and am having an aluminium tank fabricated that will fit in the recess under the front of the seat, between the twin 10 litre JVO tanks...
Pics to follow shortly I hope, but essentially there is enough space there for a 5 litre 'reserve' tank, which is the same volume I had using the Safari Tank on the rear fender that I used in Tunisia... Tamsin Jones only had 25 litres on her Dakar bike last year (15L front, 10L rear), so I reckon I'll be fine range-wise with 25 litres of fuel... and I can also take along the rear Safari Tank as an auxiliary should I feel the need for even more fuel on board!
I'm also having a pair of 1.5L water tanks made that will fit either side of the Flatland Racing 'enduro' bashplate I fitted after Tunisia (it was delayed in transit prior to Tunisia, due to that volcanic dust cloud - seems like an age away now doesn't it?!):
I really like the simplicity and compact nature of this plate, however, while I had the requisite 3L of water in a camel-bag between the JVO tanks in Tunisia (and my old XR650 bash-plate bodged on last minute!), I felt ultimately the space between the tanks would be better served for fuel, and so the natural place for the water is now down below...
Of course I could have bought something commercially available (although I'm not sure the Meca'system Aluminium rally tank for example would fit around the lower JVO tank brackets, and even if it did, it's €599!) and the natural choice would have been the carbon bashplate that JVO supply (still €400 btw, plus you need a pair of bladders). However, while I'm sure it has proved very robust (as I'm sure Neil can confirm), I still prefer to have a chunk of metal under my sump, so we'll see how it turns out!
Not sure what kit Craig is using - I met him briefly the other week (Tamsin was doing an 'evening with' talk as part of an organized weekend of trail-riding in Wales) and his plans were still slightly sketchy, although he confirmed he'd be on a WR this year...
Yep - It's going to get exciting real quick (if it isn't already eh?!)
J x
Honda CB500X 'Adventure' - not a unicorn as such, just a little mule with a bump on it's head...
JMo (& piglet) screwed with this post 09-07-2010 at
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European Neuropsychopharmacology
- Print ISSN
- Electronic ISSN
- 1873-7862
- Impact factor
- 4.201
- Publisher
- Sciencedirect
- http://www.sciencedirect.com/science/journal/0924977X
- Usage rank
- 2775
- Article count
- 1650
- Free count
- 6
- Free percentage
- 0.00363636
- PDFs via platforms
- Sciencedirect, Gale, Ingenta, CSA, Rcgp, and Proquest
The therapeutic or prophylactic effect of exogenous melatonin against depression and depressive symptoms: a systematic review and meta-analy...
European Neuropsychopharmacology 24(11):1719 (2014) PMID 25224106Our outcome was measurement of depression/depressive symptoms with a validated clinician-administered or self-rating questionnaire. PRISMA recommendations were followed and the Cochrane risk-of-bias tool used. Ten studies in 486 patients were included in the final qualitative synthesis and four stud...
Title Page
European Neuropsychopharmacology 25:i (2015)
European Neuropsychopharmacology 25:ii (2015)
ASP5736, a novel 5-HT5A receptor antagonist, ameliorates positive symptoms and cognitive impairment in animal models of schizophrenia.
European Neuropsychopharmacology 24(10):1698 (2014) PMID 25108314We recently identified ASP5736, (N-(diaminomethylene)-1-(3,5-difluoropyridin-4-yl)-4-fluoroisoquinoline-7-carboxamide (2E)-but-2-enedioate), a novel antagonist of 5-HT5A receptor, and here describe the in vitro and in vivo characterization of this compound. ASP5736 exhibited a high affinity for the...
Glutamate-mediated excitotoxicity in schizophrenia: a review.
European Neuropsychopharmacology 24(10):1591 (2014) PMID 25159198Findings from neuroimaging studies in patients with schizophrenia suggest widespread structural changes although the mechanisms through which these changes occur are currently unknown. Glutamatergic activity appears to be increased in the early phases of schizophrenia and may contribute to these str...
The expression of contextual fear conditioning involves activation of a NMDA receptor-nitric oxide-cGMP pathway in the dorsal hippocampus of...
European Neuropsychopharmacology 24(10):1676 (2014) PMID 25174523We observed a reduction of contextual fear conditioning after dorsal hippocampus administration of either the neuronal NO synthase inhibitor N-propyl-L-arginine, the NO scavenger c-PTIO or the guanylate cyclase inhibitor ODQ. Therefore, the present findings suggest the possible existence of a dorsal...
The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.
European Neuropsychopharmacology 24(9):1492 (2014) PMID 25044051We investigated the effect of '523' on cognitive performance in a sample of cognitively normal Jewish elderly with type 2 diabetes, a group at particularly high risk for cognitive impairment. Using a MANCOVA procedure, we compared homozygous carriers of the S/S allele (N=179) to carriers of the VL/V...
Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence.
European Neuropsychopharmacology 24(7):1123 (2014) PMID 24721318We analyzed the mRNA expression profiles of genes that code for all components of serotonergic and dopaminergic synapses, in 16 brain areas from human and non-human primates from public domain databases, to detect genes whose expression changes during adolescence. Two serotonin receptors, HTR1E and...
The effects of nicotine on cognition are dependent on baseline performance.
European Neuropsychopharmacology 24(7):1015 (2014) PMID 24766971We conducted a double-blind randomised placebo-controlled crossover trial, examining the effects of placebo, 1, and 2mg of nicotine on cognition in young (n=16, age 18-30 years) and healthy elderly (n=16, age 60-75 years) subjects. We hypothesised that the elderly would benefit more from nicotine co...
Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET.
European Neuropsychopharmacology 24(2):251 (2014) PMID 24239329Tesofensine (TE) is a novel triple monoamine re-uptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine, norepinephrine, and serotonin. In recent preclinical and clinical evaluations TE showed a robust anti-obesity effect, but th...


text:
The Food Basket
- Street:
- 140 St Kilda Road, Ronderbosch East
- Postcode/City:
- 7780 Cape Town
- Province:
- Western Cape
- Phone:
- 021 696 9459021 696 9459
- Fax:
- 086 6119726
- Website:
- thefoodbasket.co.za
- E-mail:
- Send message
We specialize in finger food, hot meals, salads and desserts and we have a "no compromise on quality" policy. We offer a wide selection of Eastern and Western dishes by having over 300 items on our menu. We do not saddle our clients with pre-set menus they may not like; instead we give you the opportunity to select your own combination of finger foods or main meals. Thus all our quotes are unique and are specifically tailored to suit the individual. In order to satisfy the client with specific cuisine requirements we will willingly go the extra mile and accommodate their needs – even if it is beyond our normal menu.
Our clients are mainly divided into the following four categories:
Regular meetings, Training sessions, Large corporate events, Outdoor events.
Tour Groups / Bus Trips:
Pre-packed meals, Picnic boxes.
Hotels / Restaurants:
Plated Hallaal meals, Buffet Hallaal meals .
Private Functions:
Any reason for a party.
Lunch at The Office in Cape Town
hasienakhan, 12 December 2013
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text:
Animated Props
The devil is in the details. Prepare your home for Halloween fun when you fill it up with small animated props! All of these props are around three-feet tall or shorter, letting you save space for your guests. Cute, creepy, silly...we have every kind of decoration you could hope for. Look through our selection and you're bound to find a favorite!
Haunted Evil Twins Animated Prop
Frightening Upside Down Hanger Animated Ghoul Prop
Freaky Upside Down Hanger Animated Clown Prop
Light-Up Feral Stuffed White Bear Prop
6' Headless Horseman Animated Prop
6ft Life-sized Animated Pennywise Prop
Motion Sensored Sanatorium Hanged Prop
Animated Aristocrat Corpse Prop
Animated Feral Furry Stumps Prop
Motion Sensored Zombie Assassin Prop
Wheelchair Grandma Moving Prop
Hung & Hooked Clown Moving Prop
Over Five Foot Helga Fortune Teller Animated
2' Animated Spewing Corpse Fog Machine Accessory
Honky the Clown Prop with Animation
2' Animated Wretched Reaper Fogger Prop
2' Animated Gaseous Zombie Fogger
70" Evil Entity Prop with Animation
When trick-or-treaters are walking up to your doors, you don't want to make it too easy to reach the candy. Lunging snakes will try to bite their feet off as they move, while miniature psycho clowns will jeer at them from their cages! Lighten the mood with a banjo-playing skeleton and set up a hanging man that will kick in time to the music. If you need to get their appetites up, set down Regan on her silver platter and she'll have everyone eating in fear!
What would a Halloween set-up be without a demon or two? Our monstrous babies are a great way to spook out new parents, letting you tease them with grumpy mummies and head-spinning infants. Some of them are just old enough to take their first steps across your floor! Just be careful that they don't bite your feet off when they make it over to you.


text:
1: Stubbs
2: Renteria
3: Votto
4: Phillips
5: Bruce
6: Rolen
7: Gomes
8: Hanigan
9: Bailey
1: Stubbs
2: Renteria
3: Votto
4: Phillips
5: Bruce
6: Rolen
7: Gomes
8: Hanigan
9: Bailey
Baby Bears counter with
Renteria .382 lifetime BA vs. Z.
"A person is smart. People are dumb, panicky, dangerous animals and you know it."
Gomes must go.
Can't win with 'em
Can't win without 'em
Not surprised if Zambrano eats Gomes up all night. Not a good combo.
Baseball is like church. Many attend, few understand
I do wonder how much more leash Gomes has left. I know Dusty likes to be patient with guys, and it payed off with Bruce & Stubbs last year, but at some point its got to be a detrament to the mental health of the team every time they look at the lineup card and see Gomes penciled in at this point.
And this game is underway.
Let's go Homer. Keep it rollin' Mr. Bailey!
Those are some nice batting averages the Cubbies have up to Byrd. Soriano is the only lower one but he's got the power to offset it.
Of course the bottom of the order is horrendous.
Barney BB
Board Moderators may, at their discretion and judgment, delete and/or edit any messages that violate any of the following guidelines: 1. Explicit references to alleged illegal or unlawful acts. 2. Graphic sexual descriptions. 3. Racial or ethnic slurs. 4. Use of edgy language (including masked profanity). 5. Direct personal attacks, flames, fights, trolling, baiting, name-calling, general nuisance, excessive player criticism or anything along those lines. 6. Posting spam. 7. Each person may have only one user account. It is fine to be critical here - that's what this board is for. But let's not beat a subject or a player to death, please.


text:
Free Conference Call International
Free Conference Call Dialer provides a quick and easy way for you to host or join conference calls without having to remember the dial-in...
Free Conference Call Dialer provides a quick and easy way for you to host or join conference calls without having to remember the dial-in...
Microsoft's Service Fabric will target first ISVs and startups building public cloud applications, and later come to Windows Server and Linux.
Microsoft's Windows 10 software development kit for writing universal apps is now available for download.
Microsoft's Enhanced Mitigation Experience Toolkit (EMET) tightens the security screws in Windows and applications. It's set up for enterprise deployment and management.
Amazon expands support for its streaming service that targets games developers to any Windows application.
Use of Windows XP fell dramatically last month, while use of Windows 8.1 grew dramatically, according to Net Applications' numbers published at Netmarketshare.com. Is this a fact, an erroneous blip, or a historical correction? You decide…
Taskbar Hide, hide program windows completely with a hot key, or minimize programs to the system tray instead of keeping icons in your...
Microsoft is building new container technologies into the next Windows Server release, enabling Dockerized applications to run on Windows Server on-premises or on Azure.
If you're envious of the affordability of Chrome OS laptops, but need to run Windows applications, Lenovo's 15.6-inch B50-30 has much to recommend it.
Kat Player is an advanced music manager and audio player to best fit the needs of all music lovers. Very permissive, it supports all...
CodeWeavers latest CrossOver has many improvements, one of which is that it makes it easier than ever to install Windows applications on Linux.
Net Applications has found that Windows 8.x actually lost user share in June 2014, while Windows 7 has really been the operating system to gain from XP's end of support.
Microsoft has taken steps to ease onerous restrictions that have curtailed development of business applications for Windows 8. But some say the company still hasn't gone far enough.
Microsoft is updating its remote desktop applications for non-Windows platforms, but still has yet to make available a Microsoft-developed version for Windows Phone.
BluffTitler bridges the gap between the limited special effects available in titler utilities often bundled with video NLEs and the functionality in high-end applications like Adobe After Effects.
The CloudBridge offering also comes bundled with applications from Qumu, Talon and Cortado along with up to two virtual Windows Server images.
AppZero is collaborating with Microsoft to persuade users of Windows Server 2003 to update before Microsoft stops supporting the operating system using AppZero's application virtualization technology.
As Microsoft winds down support of the Windows XP operating system, suppliers of application virtualization solutions are ramping up their marketing messages. While it is true that encapsulating Windows XP applications can make it possible for them to run on Windows 7 or 8, is that the answer?
One organisation has used a Windows XP migration project to discover the true extent of the software on its books and just how much of it is really being used.
Microsoft has opened up to testers the limited preview of the premium tier of its Windows Azure SQL database for business-critical applications.
Windows RT and Windows Phone 8 aren't doing well, but Microsoft can still make out with some help from Intel and Windows 8.1 If its great ARM experiment doesn't work out, supporting Microsoft's key applications on Android and iOS won't hurt.
Microsoft appears ready to roll out the set of expected updates to its full set of core, Microsoft-developed Windows 8 applications, as rumored earlier this month.
Latest figures from Net Applications shows that Windows 8's market share stands at just 2.67 percent, five months after it was first released. (That's nearly half of Windows Vista's share.)
Windows 10
How much does an iPhone 6 really cost? (Hint: It's way more than $199)
How to survive an iPhone liquid submersion (hint: it's not rice)
Microsoft's new mission statement: No more computer on every desk


text:
Find out more
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Jordans Trust Company Limited specialises in tax planning, formation & management services for UK & offshore companies, trusts & foundations.


text:
Coming to America...
View Single Post
Wage slave...
Joined: Jul 2002
Location: Scarning, Norfolk, today...
Oddometer: 7,095
Flying Back to North Carolina...
20th February
Up early, as Buddy has to go to work today! Well, to a meeting anyway no need to go crazy
. I say my heartfelt thanks to Buddy & Sue for their generous hospitality and Im packed and on the road by 0815. I decide to set course for the Outer Banks and the home of powered flight Kittyhawk. The weather is beautiful, brilliant blue cloudless sky and already above freezing. I make my way South West, re-entering North Carolina at 1100.
Im struck by the odd marketing strategy of some companies over here would you
go in and ask for a Sheetz Sandwich?
I stop for lunch at a traditional chrome diner. This might have been here since the fifties, but I suspect its a modern reproduction.
These diners sprung up all over the USA between the 30s & 50s, their design being such that, if they werent successful in a location, they could be uprooted and moved without too much drama. This one has a reserved seat at the counter
The food, regrettably, is mediocre :( Ah, well
I ride on, arriving at Kill Devil Hill at about 1400. The visitor centre here is run by the National Parks Service, so the pass I bought yesterday gets me in free ;). I wander around the museum, looking at the replica Wright Flyer and the genuine exhibits of the crude tools that Wilbur & Orville used to build the worlds first powered aircraft.
I then walk out to the worlds first runway. The first flight took place on 17th December 1903. The Flyer flew four times that day, with the toss of a coin deciding that Orville Wright would be the first pilot. They then took it in turns to increase the distance flown from 120 feet to 852 feet by the end of the day. The large boulder in the foreground represents the take-off point and the other stones in the middle distance signifies the 4 landing points
less than 66 years later, Neil Armstrong stepped onto the surface of the moon.
The flight is commemorated by a huge art-deco monument on the hill overlooking the runway.
I set off South, then turn inland, through Roanoke Island and make my way West. I intend to get to the Blue Ridge Parkway at some time during Saturday it shouldve had enough time to thaw out a bit by then
. The temperature has climbed and Im wearing my summer gloves for the first time in over a week. I ride past signs warning of bears and deer. As I cross the long, causeway-like, bridges which join the Outer Banks to the mainland, I see pelicans almost hovering in the onshore breeze.
Further inland, the ditches alongside the highway (called, ominously, Alligator Road) are flooded and there is further evidence that this entire low-lying area was hit hard by Hurricane Isabel last year too
I pull in to a cheap motel in Edenton, and get to work on the (lengthy) business of uploading my pictures to SmugMug and writing up my journal
All text & original photos © Mike Oughton 2004 - 2015
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01/16/2014 Gold Coast Fastway Catamaran Championships - Southport Yacht Club
The Gold Coast Fastway Australia Day Weekend Catamaran Championships is deemed South East Queensland's biggest off the beach Catamaran regatta. An annual event hosted by Southport Yacht Club, proudly sponsored by Fastway Couriers.Attracting boats...>>>>
01/16/2014 ROYAL SOUTHERN YACHT CLUB ANNOUNCES THE DAVID THOMAS REGATTA MAY 9th-10th-11th
Hamble, Hampshire, UK: In 2014, the yacht designer and sailing legend David Thomas is celebrating 25 years as a member of the Royal Southern Yacht Club and, in recognition, the Royal Southern is inviting owners of David Thomas-designed yachts...>>>>
01/15/2014 Key West Race Week - Delivering Excellence for 27 Years
Key West, Florida Keys -- Quantum Key West 2014 is gearing up for its trademark full week of racing on the aqua-colored waters off the coast of the Conch Republic. From the professional-laden 52 Class to top tier club-oriented programs in the...>>>>
Ahead of being shipped to China on Wednesday, Green Marine have now officially handed over the Volvo Ocean 65 'Dongfeng' to OC Sport. On the other side of the globe in Sanya, China the Dongfeng Race Team is preparing to put Chinese...>>>>
12/16/2013 The Clipper Race - Race 5, Day 11: Finish line in sight for PSP Logistics
After racing over 2,000 miles from Albany, Western Australia PSP Logistics is just 15 miles away from crossing the finish line into Sydney, Australia. PSP Logistics is expected to cross the finish line between 2200-0000 (local time). Ahead of its...>>>>
12/16/2013 Bushell wins "best and worst media job in the world" as Abu Dhabi's onboard reporter
Experienced multi-media broadcaster Tom Bushell landed the first onboard reporter position for the Volvo Ocean Race 2014-15 on Wednesday. The sport presenter saw off a long list of challengers for one of the toughest assignments in the media. Back...>>>>
12/13/2013 A mighty union!
This Wednesday 11 December, at the Nautic Paris Boat Show, Franck Cammas, Michel Desjoyeaux and Olivier de Kersauson presented Team France, which is dedicated to the next America's Cup as well as the training up of young engineers and racers. A...>>>>
Podium finishers also leading overall Clipper Race to date (provisional results to be ratified) Henri Lloyd crossed the finish line into Sydney, Australia at 0315 local time (UTC+11), claiming its fourth consecutive podium result and its first win...>>>>
12/12/2013 A strong programme and confirmed ambition for Groupama sailing team
Triple Match Racing Champion of France, Champion of offshore racing and Olympic sailing, winner of the Tour de France à la Voile, the Semaine Olympique Française (French Olympic Week) and finally World C-Class Champion, Franck Cammas has scored a...>>>>
12/03/2013 Two yachts under repair after collision at Clipper Race 5 start line in Australia
Following a collision between GREAT Britain and PSP Logistics at the start of Race 5 of the Clipper Round the World Yacht Race in Albany, Western Australia, both boats are having a full damage assessment in port.It is hoped GREAT Britain will be...>>>>
12/03/2013 Bekking and Brunel back for Volvo Ocean Race 2014-15
Amsterdam – December, 2013 - Dutch sailor Bouwe Bekking will return for a record-equalling seventh bid for the Volvo Ocean Race 2014-15, the world's leading crewed offshore race, as skipper of a new campaign launched by Brunel on Tuesday in...>>>>
The 270 amateur crew on the current leg of the 2013-14 edition of the Clipper Round the World Yacht Race have started the 2150 mile fifth stage to Sydney from Albany, Western Australia. Race 5 is the fleet's second dip into the Southern Ocean which...>>>>
12/02/2013 New Team Garmin Clipper Round the World Yacht Race skipper takes over
The new Team Garmin Clipper Round the World Yacht Race skipper Mark Burkes has officially taken over from Leg 3 skipper, Ben Bowley after the yacht's arrival into Albany, Western Australia on Friday. Mark Burkes, 48, from Worcestershire, UK,...>>>>
11/29/2013 Only Williams stands in the way of Canfield's first World Title
K Terengganu: Ian Williams bounced off the ropes to keep his hopes of a fifth world title alive after scraping through a tense Quarter-Final in the Monsoon Cup in Malaysia today.Meanwhile, in the bigger battle to decide the 2013 winner of the Alpari...>>>>
11/28/2013 One of the tightest Clipper Race finishes ever as fleet arrive in Albany, Western Australia
After 5,000 miles of racing, less than four minutes separated four yachts at the finish line of Race 4 off Albany Waterfront Marina in Western Australia in a spectacular finish witnessed by cheering crowds. Old Pulteney finished in eight position...>>>>
11/28/2013 Spindrift 2 is back
After leaving on October 7 from Lorient for Portimao for the standby for the Discovery Route, Spindrift 2 is back in Brittany. In 1 month and 19 days, Spindrift 2 has covered 10,317 miles, broken the record for the Discovery Route with a new record...>>>>
11/22/2013 All to play for at the 2013 Alpari World Match Racing Tour Final!
The world's top match racing skippers are in full preparation for next week's season finale of the 2013 Alpari World Match Racing Tour in Malaysia - The Monsoon Cup from 25-30 November. Any one of the top six teams on the Tour leaderboard can still...>>>>
11/22/2013 PSP Logistics smash the Clipper Race 300 mile barrier
In the last 24 hours PSP Logistics – which is competing in the Clipper 2013-14 Round the World Yacht Race - has set a new record for the number of miles covered in a day as it continues its campaign to win the world's longest ocean race. Between...>>>>
11/22/2013 One week until 2013 Volvo Yachting Excellence Awards
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11/07/2013 Transat Jacques Vabre: Off and Racing
The 11th edition of the Transat Jacques Vabre started under grey, drizzling skies in light winds at 1300hrs (local) off Le Havre's Saint Adresse beach. The 44 boats, 26 Class 40s, six Multi 50s, 10 IMOCA Open 60s and two MOD70s broke the start line...>>>>
11/07/2013 Record breaking Raymarine
November 2013 – Raymarine, leading marine electronics manufacturer, has made history this week following an announcement that it is the first company to ever receive four METS DAME Award nominations.Considered to be the most prestigious design...>>>>
11/06/2013 Spindrift 2 new holder of the Discovery Route record
After crossing the finish line in San Salvador in the Bahamas this morning just before 0600hrs GMT, Dona Bertarelli and Yann Guichard's maxi trimaran, Spindrift 2, has beaten the previous record for the Discovery Route, held since 2007 by Franck...>>>>
10/30/2013 Team Dongfeng announced as Chinese entry in the Volvo Ocean Race 2014-15
Wuhan, China – October 30, 2013 - A team from China backed by Dongfeng Commercial Vehicle and run by leading sailing experts OC Sport will race in the next edition of the Volvo Ocean Race in 2014-15.Team Dongfeng will have the interests of Chinese...>>>>
09/18/2013 Raymarine's Evolution™ autopilot takes innovation award at IBEX 17-19 September 2013
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09/13/2013 Six days to the start
From next Saturday, September 21st, 90 classic yachts, 40 Dragons and 8 Broad One Design (BOD) will take part to the 35th edition of the Régates Royales – Trophée Panerai. In the magnificent backdrop of the Bay of Cannes, some one thousand sailors...>>>>


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Tom Worm and Andy Nitchals fish the rip rap near the launch site.
Tom Worm and Andy Nitchals fish the rip rap near the launch site.
Tom Williams and Nick Leonard had to come in early due to a broken trolling motor.
Tents provided the only shade for the spectators during this scorching weigh-in.
First flight contenders trudge up to the weigh-in tents to get out of the sun.
The weigh-in line fills up with first flight anglers.
Tom Williams weighed in a smallmouth and became a great-grandfather today.
Ian MacDonald, 4-7.
Jim Severson, 15-9.
Andy Hriber, 11-0.
Ron Eicher, 11-4.
Jeff Bostic, 17-5.
Nathan Gray, 10-9.
Danny Ryan, 5-7.
Chad Richardson, 2-10.
Ted Prisbe, 16-12.
Cliff Van Beek, 1-12.
Jeff Brown, 8-0.
Eric Storms, 18-8.
Mike Kujawski, 10-1.
Stan Dodson, 14-14.
Northern Divisional contenders head back to the ramp after the Day 2 weigh-in.


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BROOKSTON, TEXAS. Brookston is at the intersection of Farm roads 38, 1506, 1509, and the Missouri Pacific Railroad, just south of U.S. Highway 82 and five miles west of Paris in west central Lamar County. The town, originally part of the Zachariah Westfall survey, was established in 1870; it became the temporary terminus of the Texas and Pacific Railway when completion of the road was delayed during the panic of 1873. The post office was established that year and named for A. D. Brooks, owner of the land. By 1884 the population had reached 100, and Brookston was an important cotton-shipping point. Contemporary businesses included two general stores, a steam-powered cotton gin, a corn mill, a saloon, and a Western Union telegraph office. Mail arrived daily. Citizens numbered 500 in 1890. A new cotton gin was soon opened, as well as two more general stores, four groceries, a blacksmith shop, a butcher shop, a drugstore, a candy emporium, and a wagonmaking establishment. Within two years three churches were established, and residents acquired access to a telephone exchange. The major new commercial enterprise was Mrs. M. Hemphill's hotel. Municipal officials included Constable A. R. Bryant and Justice of the Peace C. G. Hunt. The school had been organized by 1896, when ninety-nine students were enrolled. It had two teachers.
The early railroad years were the most successful for Brookston, however, and by 1904 the population had decreased to 237. In 1914 the town had 225 citizens, a new hardware store, and a life insurance company, but some businesses were closing. Though the number of inhabitants had increased to 300 by 1925, the economic boom of the early days never returned. The town was also hard hit by the Great Depression. In 1930 only 130 people lived in Brookston. Many local residents moved away to metropolitan areas in search of work. Some of these had returned by 1933, but the number of businesses had decreased from twelve in 1931 to eight. Maps for 1936 showed three churches and two school buildings. By 1957 the school system had been consolidated with the West Lamar Independent School District, and residents numbered 250. In 1970 the number of businesses had dropped to two, and the population had decreased to 200. Maps for 1984 identified two churches, a small school building, and a cluster of dwellings. In 1990 Brookston had seventy inhabitants, three stores, and the post office. The population remained unchanged in 2000.
Thomas S. Justiss, An Administrative Survey of the Schools of Lamar County with a Plan for Their Reorganization (M.A. thesis, University of Texas, 1937).
The following, adapted from the Chicago Manual of Style, 15th edition, is the preferred citation for this article.Vista K. McCroskey, "BROOKSTON, TX," Handbook of Texas Online (http://www.tshaonline.org/handbook/online/articles/hnb84), accessed July 06, 2015. Uploaded on June 12, 2010. Published by the Texas State Historical Association.


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A boy lies wounded after a bomb exploded in the Palestinian Camp of Nahr al-Bared in north Lebanon, Wednesday, April 24, 2013. (The Daily Star/Antoine Amrieh)
BEIRUT: Ten people including schoolchildren were wounded Wednesday in an explosion in the Palestinian Camp of Nahr al-Bared in north Lebanon, security sources told The Daily Star.
Preliminary investigations revealed that children were playing with a bomb left over from the 2007 clashes, between the Lebanese Army and fighters from Fatah al-Islam in the camp, when it exploded, the sources said.
Three teachers and seven children were wounded.
A member of the Central Committee of the Democratic Front for the Liberation of Palestine, Abu Louay Arkan, hoped for a speedy recovery for the wounded that he visited at Al-Khayr Hospital in Minyeh.
He urged for renewed efforts in the reconstruction of Nahr al-Bared, which would allow for the return of residents and prevent similar incidents from taking place.
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Experts back controversial Tripoli parking lot plan, with reservations
Two shootings in north Lebanon, no casualties
Two refugees injured in north Lebanon fire


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Gesine is back with Agnes and they are making GESINE'S STARRY STARRY NIGHT COOKIES as seen in "Confections of a Closet Master Baker."
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Bridging Belief, Sexuality & HIV – Tues 7/28 10 AM
Bridging Belief, Sexuality & HIV Tuesday, July 28, 10:00 AM Google Hangouts On Air - Broadcast for free Spiritual and religious communities provide a sense of identity, belonging, and comfort...
research helps | help research
Happy Tax Day, my Sweets –
"How well does it work?"
"Does it make people have side effects?"
These are the two most important questions anyone will have about a new medicine they are considering to take or prescribe.
And when it comes to HIV treatments, these two questions have been answered definitively time and again by the grand dame (French for 'great lady' and pronounced like "grond dom") of HIV research networks that I work for: The AIDS Clinical Trials Group (ACTG).
You may have missed at the beginning of March, the ACTG presented the initial results of its last large study of people who were starting HIV meds for the first time: A5257 are the numbers we use to refer to it.
(the long-winded title of the study: A Phase III Comparative Study of Three Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)-Sparing Antiretroviral Regimens for Treatment-Naive HIV-1-Infected Volunteers [The ARDENT Study: Atazanavir, Raltegravir, or Darunavir With Emtricitabine/Tenofovir for Naive Treatment])
The study compared three different regimens, asking these two big questions "How well do they work?" and "Do they make people have side effects?"
· Truvada + Isentress (raltegravir)
· Truvada + Reyataz (atazanavir) boosted w/ ritonavir (Norvir)
· Truvada + Prezista (darunavir) boosted w/ ritonavir (Norvir)
The big news was that the study gave us an answer: the Isentress® + Truvada® regimen was better than the other two.
Why is this important?
Globally, efavirenz (Sustiva®) is the most commonly prescribed HIV drug, according to the World Health Organization guidelines.
But many people are not good candidates for Sustiva®, such as women contemplating pregnancy or people with psychiatric disorders.
A5257 was designed to provide a comprehensive comparison of non- Sustiva® based regimens.
And now, for the many people who need to avoid Sustiva®, we have an answer as to the best options for them.
This large treatment study is the last of its kind, and there will be a wealth of information yet to come of it.
This study will be especially helpful when it comes to asking questions about the differences for men and women taking these regimens.
About a quarter of the people enrolled were women—which nearly matches the percentage of women in the US living with HIV.
I have found for you a link to a video where two doctors associated with the ACTG discuss these study results.
VIDEO LINK: http://www.medscape.com/viewarticle/823164?nlid=54323_721&src=wnl_edit_medp_aids&uac=10870BX&spon=1#1
What they talk about to me is easier to listen to than to read.
However, I also pasted below the transcript of what they talk about, for those of us who prefer to read this kind of information.
Thank you to all who participated in this study, which started enrolling way back in 2008.
Your willingness to help research answer these questions will benefit the many people around the world about to begin taking HIV medicines.
And, since it is April 15th, infamously known as TAX DAY, it is only fitting that I thank all of you who dutifully pay your federal income taxes year after year.
For without your tax dollars, federally funded HIV research such as this study would never be done.
Your tax dollars help us establish as objectively as possible what is verifiably true.
The ACTG and its members are not motivated by financial gain or profit, but by what is best for the health and wellbeing of people around the world living with HIV
Without the ACTG and your tax dollars, HIV+ people would have to rely on research conducted by pharmaceutical companies alone, whose track record regarding the results of their own studies always remains in question.
Think about what that reality might have meant for HIV+ people everywhere, and perhaps Tax Day will not seem as awful…..
– Michael
VIDEO LINK: http://www.medscape.com/viewarticle/823164?nlid=54323_721&src=wnl_edit_medp_aids&uac=10870BX&spon=1#1
Selecting an Initial ART Regimen: Lessons From ACTG 5257
Paul E. Sax, MD, Raphael J. Landovitz, MD
April 11, 2014
The Need for ACTG 5257
Paul E. Sax, MD: Hello. This is Dr. Paul Sax from Brigham and Women's Hospital and the Harvard Medical School. Welcome to this Medscape interview.
Today I'm pleased to introduce the person I will be discussing our topic with: Dr. Raphael Landovitz (or Raphy Landovitz), who is Associate Professor of Medicine at UCLA, a former colleague, and a good friend.
Today's topic will be selecting an initial antiretroviral therapy (ART) regimen for people with HIV. The reason that it is particularly notable that we are going to have Dr. Landovitz on today's interview is that he recently was asked to present the results of a major HIV clinical trial [at the 2014 Conference on Retroviruses and Opportunistic Infections (CROI)].
Raphy, let's discuss that clinical trial and at least discuss the rationale. It is called ACTG 5257.[1] What was the reason behind doing this comparative clinical study?
Raphael J. Landovitz, MD: Thank you, Paul, and thanks for inviting me to this conversation.
ACTG 5257 was borne out of the observation that although tenofovir/emtricitabine/efavirenz (TDF/FTC/EFV) is the most commonly prescribed antiretroviral combination worldwide, there is not an insignificant number of patients for whom it is not actually recommended or is intolerable.
This includes women of childbearing potential, particularly if other options are available, and people with some comorbid mental health issues, and a lot of drug-drug interactions preclude its use. Perhaps most provocatively, it is not recommended in people who have themselves been infected with virus that is resistant to some of the components of this combination, which can happen in up to around 15% of new infections.[2]
So the question was, given the list of other first-line antiretroviral regimes that are recommended in the US Department of Health and Human Services guidelines,[2] is there one that would be preferable if the efavirenz-based combination could not be used? We wanted to see not just a short-term follow-up comparison but long-term clinical outcomes with all of the components that are important for a comprehensive evaluation of those regimens, including metabolic complications, tolerability, and, of course, virologic efficacy of the regimens.
Dr. Sax: Can you be specific? Which regimens were compared? How did people end up on them? Was it open-label, was it blinded, etc.?
Dr. Landovitz: Yes, obviously these are critical things to know in interpreting the results of any clinical trial. The 3 regimens that were compared were all in combination with TDF/FTC, and they were
· ritonavir-boosted atazanavir (ATV/r),
· raltegravir, and
· ritonavir-boosted darunavir (DRV/r), given open-label.
HIV-infected, treatment-naive individuals were randomly assigned, in equal proportions, to each of those 3 treatment arms and were followed for 96 weeks, or almost 2 years, after the final participant was enrolled. We enrolled about 1800 people, which took about 2 years to do, so the people who enrolled right up front actually had almost 4 years of follow-up.
Dr. Sax: That is substantially sized for an HIV study. The cholesterol researchers would probably still think it is pretty small, but for an HIV initial therapy trial, it is large. Why such a large sample size?
Dr. Landovitz: We were interested in having statistical power to answer some very specific questions. These were questions involving what we call pair-wise comparisons for each of those 3 treatment arms. Even though we had 3 arms, we wanted to look at every possible combination and be able to say something about how each one compared to the others with regard to a number of endpoints, such as how well it suppressed the virus for our virologic efficacy endpoint and how well it was tolerated.
Then we looked at a combination of those 2 endpoints, which we called a composite endpoint of virologic failure and tolerability. We thought this was actually the most relevant endpoint for clinicians and patients because it took into account the 2 most important things that clinicians and patients were interested in: How well does it work, and does it make people have side effects?
Noticeable Focus on Female Participants
Dr. Sax: Let's now skip to the results. I am going to ask you about the baseline characteristics, and I am going to focus on something that was quite noticeable when you presented the data at CROI: The study had about 25% females, which is much, much higher than other prospective clinical trials comparing initial regimens that we have seen recently.
It was done in the United States, so this was about the same proportion of women with HIV in the country. Congratulations to the study team for doing it. But how did you do that?
Dr. Landovitz: You are very kind for thinking that that is something worth noting. We were really focused at the beginning on enrolling a third of the participants as women. That was our original plan. We noted the results of other studies within the ACTG, and without, about some really important differences in tolerability of regimens and even some apparent differences in efficacy in women in both US-based and international initial treatment studies.[3] So we really thought that having enough women to be able to make statements about this — whether these results were going to be different in women — was important.
It is challenging to enroll women in clinical trials, at least within the HIV realm in the United States. People have thought of all sorts of reasons why that might be, but I don't think anyone knows for sure. Historically, we haven't done a great job of engaging women in the clinical trials process and communicating to them why it is important that they participate. They have other competing priorities, such as childcare, and a lot of these patients are single moms trying to juggle life.
Dr. Sax: Also, they are in a substantially lower socioeconomic group, on average, in the United States than are the men with HIV. It is just a very stark difference. But back to my question: How did you do it?
Dr. Landovitz: We focused all the sites on enrolling women from the start. But we lagged very far behind and it became clear that unless we made a push for doing so, we weren't going to be able to enroll a substantial portion of women.
So we put limits on the sites. We said, "In order to enroll your next man participant, you need to enroll a woman participant." Eventually, we had to close the study to male enrollment and just allow enrollment to women in order to get about a quarter of participants, which is what we got in the end.
Dr. Sax: Again, congratulations to the study team. It is very important that you did this, and I will also note that you ended up enrolling the study still within the time that you had predicted. So, good work.
Tolerability Drives the Difference
Dr. Sax: Now on to the results and the virologic, tolerability, and composite results. Tell us what you found. Focus first on the virology.
Dr. Landovitz: We designed this as an equivalence study. What that meant is that if 2 regimens have virologic suppression rates within ±10% of each other, it was clinically going to be an equivalent result. So we defined equivalence as the point estimate for virologic failure falling within ±10% for the difference of any pair-wise comparison as equivalent.
And we found all 3 regimens to be equivalent in regard to virologic efficacy. That was exciting. The rates of virologic suppression at our primary endpoint of 96 weeks were very similar and outstanding for all 3 arms — 88% to 94% were suppressed.
Dr. Sax: It is safe to say that probably most of the nonsuccess in using these modern regimens was due to nonadherence or other factors, not specific drug factors, correct?
Dr. Landovitz: That is probably right, yes.
Dr. Sax: So how about the other results? Not the same story, is it?
Dr. Landovitz: It isn't, and this was a little bit of a surprise. In regard to the tolerability endpoint, the ATV/r arm was inferior to both other arms — it was inferior to DRV/r and inferior to raltegravir. The DRV/r and raltegravir arms, in regard to tolerability, were equivalent.
The driving force of that result appeared to be a jaundice syndrome that was associated with elevated bilirubin levels, but the people who stayed on the ATV/r regimen and the people who found that intolerable didn't have vastly different rates of elevated blood chemistry testing for bilirubin. There were more extremely high elevations of bilirubin in the people who did stop than in those who didn't, but it was very interesting, and this was a notable difference to other studies that have used ATV/r.
As you well know, a number of studies have found fairly low rates of people stopping ATV/r for this jaundice/hyperbilirubin syndrome. We thought a lot about why our study might have been different, and you and I have talked about this. We've surmised that maybe it's because our study design allowed people to switch to other really good, well-tolerated regimens within the confines of the study. And that, perhaps, set a lower bar for people being willing to discontinue their ATV/r treatment when they knew other drugs were available very easily through the study and they wouldn't be asked to discontinue the study.
Dr. Sax: As we have mentioned (and I am going to underline one of the things you said), there are other very good options out there, and 2 of them were within the study that you were conducting. So a person who experienced hyperbilirubinemia and may have thought it a mild cosmetic problem had very little reason not to switch, as opposed to back in the early 2000s when atazanavir came out and there weren't as many good options.
So you have this effect, and the composite results (I am just going to summarize) showed the same thing: Raltegravir worked better than both of them. It was a little bit better than DRV/r in the viral outcome and a little bit better than DRV/r in tolerability. So who is the real winner in this study?
Dr. Landovitz: If I can extrapolate the results, it is the integrase inhibitor class that was the winner. Clearly, our results only used raltegravir so I can't necessarily generalize to other agents. But it is clear that, from a tolerability and virologic efficacy perspective, when both are considered together, the raltegravir-based arm did the best. It was sort of compelling and it was a little bit of a surprise on 2 counts: first, that there was so much worse tolerability with the ATV/r arm; and second, as you mentioned, in the composite endpoint, that the more subtle differences between raltegravir and DRV/r in regard to both virologic efficacy and potency translated into a superiority of raltegravir over both protease inhibitor-containing arms.
I found that compelling and a little surprising, but not inconsistent with our clinical experience.
Dr. Sax: Exactly. One of the really nice things about this study is that it does have direct clinical applicability to people who are practicing.
I am going to ask you about a couple of other things that were in ACTG 5257, and then after that I am going to broaden the questions a bit. First, lipids; second, bone. Tell me about results in this study.
Dr. Landovitz: The boosted protease inhibitor arms both had greater increases in fasting low-density lipoproteins and triglycerides, which was not a surprise. Perhaps the only surprise in the lipids was that DRV/r and ATV/r were not different from each other in this large, well-powered study.[4] Other work has suggested that there might be differences between those, so we were surprised at that.
Bone changes were more subtle, but the raltegravir arm also had less bone mineral density loss,[5] so that was a win for raltegravir as well.
Dr. Sax: I guess the only place where you might say that boosted protease inhibitors still reign supreme is resistance outcomes, right?
Dr. Landovitz: Right. That is a good point. When we presented the data, we didn't get a lot of opportunity to discuss the resistance results.
It is important to remember that there were very few people who failed all 3 of the arms virologically. The fewest failures were in the raltegravir arm. But of those who did fail virologically, raltegravir failures were more likely to have resistance — not only to that third agent (in that case, raltegravir) but also to the nucleoside backbone that went with it.
That is important to note. You are not going to fail frequently, but if you do, it can compromise the backbone; in the protease inhibitor arms, it didn't.
Dr. Sax: It is remarkable. It is a consistent finding that we have seen in studies ever since that class started being used widely: Resistance simply does not develop, or does very rarely, in patients who get a boosted protease inhibitor plus 2 nucleosides.
Looking Broadly and Looking Ahead
Dr. Sax: Now let's broaden the discussion a bit. As you are aware, the Department of Health and Human Services updated their guidelines for initial therapy when dolutegravir was approved, and they did so to include, essentially, all of the integrase-based regimens, which are now listed as preferred regimens.[6] You have TDF/FTC/raltegravir; you have the single tablet of TDF/FTC/elvitegravir/cobicistat; you have TDF/FTC/dolutegravir; and you have abacavir/lamivudine/dolutegravir.
When you look at the list of preferred regimens, there are now 4 choices for integrase inhibitor-based therapy. Would you say that your study supports that change, and if so, can you comment about these a bit more? Or is it beyond the scope of the study?
Dr. Landovitz: Our study supports the inclusion of raltegravir-based regimens in the first-line preferred list. You didn't ask this, but it raises the question about whether ATV/r is going to retain its preferred first-line status, particularly when it was less well tolerated than DRV/r. That is going to be very interesting to see when the revised guidelines come out.
Our study obviously does not address the question of the elvitegravir or the dolutegravir regimens. But other head-to-head comparisons that have already been done and were presented — between DRV/r and dolutegravir, between the elvitegravir combination and ATV/r, and between raltegravir and dolutegravir — do make it likely that these results are going to be generalizable to the other integrase agents. Of course, the once-daily dosing and the smaller pill burden do make them attractive.
It is important to remember, though, that some of the tolerability gain of the integrase inhibitor is probably from the absence of the ritonavir booster, and I know there has been some experience with cobicistat having some of those same side effects. In our study, the DRV/r main discontinuation driver was a gastrointestinal syndrome.
It does probably suggest that — although we haven't proven this yet — that the dolutegravir-based regimens are going to have a leg up from a tablet perspective, a dosing perspective, and a lack of cobicistat perspective.
Dr. Sax: Raphy, this is a really interesting study. I wonder whether you had any further data coming down the pike from this study. I know the answer to that question is undoubtedly yes. One doesn't invest all of this time and energy in a study of this size and then stop with the first series of presentations.
So, what is to come from ACTG 5257?
Dr. Landovitz: Thank you for that headliner of coming attractions. As you alluded to in our opening, we invested an enormous amount of time, energy, and resources in making sure we had adequate representation of women in this clinical trial, so one of our first analyses is going to be looking at the impact of gender effect on all of these treatment outcomes in order to better clarify some of the conflicting results that have been seen in other first-line treatment trials in regard to tolerability and efficacy in women.
We are also going to look carefully at results by race and ethnicity, as virologic suppression rates have been notably different across race and ethnicity groups in ACTG trials of initial therapy and other studies. We want to delve into that more. And we are also going to do a careful adherence analysis.
Paul, as you are well aware, one of my personal interests is HIV prevention and treatment as prevention. We did a behavioral analysis in this study that is looking at what happens to people's transmission risk behavior as they initiate treatment. In other words, does the fact that they are on treatment and now becoming virologically suppressed — and given our new understanding of what that means for the transmissibility of the virus — what does that do to people's sexual risk behaviors? We have both a baseline analysis, which we have already presented[7] (and which I am sure you have seen), as well as a longitudinal analysis.
And then there is a large metabolic substudy of ACTG 5257 which has another complicated number, ACTG 5260S, that looked very carefully at some biomarkers of early cardiovascular and cerebrovascular disease, a flow-mediated vasodilation parameter, and a lot of bone markers and inflammatory markers that may predict some of these longer-term metabolic outcomes in which we are concerned about mitigating the clinical effects in HIV treatment over the long term.
There are a lot more data to come that may modify these initial results in regard to how dogmatic we are about changes in guidelines or about which regimen is best, but certainly there will be a lot more detail, particularly for different subgroups.
Dr. Sax: Raphy, I want to thank you very much for spending the time to talk about this study specifically and also about its implications more broadly.
Again, this is Dr. Paul Sax. I have been talking with Dr. Raphael Landovitz about initial therapy for HIV. Thank you very much for your attention.
Medscape HIV/AIDS © 2014 WebMD, LLC
Cite this article: Selecting an Initial ART Regimen: Lessons From ACTG 5257. Medscape. Apr 11, 2014.
Authors and Disclosures
Paul E. Sax, MD
|Professor of Medicine, Harvard Medical School; Clinical Director, Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts
Disclosure: Paul E. Sax, MD, has disclosed the following relevant financial relationships:
Served as a director, officer, partner, employee, advisor, consultant, or trustee for: Bristol-Myers Squibb Company; Gilead Sciences, Inc.; GlaxoSmithKline; Janssen; Merck Received research grant from: Bristol-Myers Squibb Company; Gilead Sciences, Inc.; GlaxoSmithKline; Merck
Raphael J. Landovitz, MD
|Associate Professor of Medicine, Center for Clinical AIDS Research and Education, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California
Raphael J. Landovitz, MD, has disclosed the following relevant financial relationship:
Received research grant from: Gilead Sciences, Inc.
Michael Louella
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Press release from CNW Group
Pure Industrial Real Estate Trust Schedules Conference Call for Q3 2012 Financial Results
Friday, November 02, 2012
Pure Industrial Real Estate Trust Schedules Conference Call for Q3 2012 Financial Results19:45 EDT Friday, November 02, 2012VANCOUVER, Nov. 2, 2012 /CNW/ - Pure Industrial Real Estate Trust ("PIRET" or the "REIT") (TSX: AAR.UN) is pleased to announce the scheduling of its conference call on PIRET's financial results for the three and nine months ended September 30, 2012.Management will host the conference call at 4:30pm (EST), 1:30 pm (PST), on Tuesday, November 13, 2012, to review the financial results and corporate developments for the three and nine months ended September 30, 2012.To participate in this conference call, please dial one of the following numbers approximately 10 minutes prior to the commencement of the call, and ask to join the Pure Industrial Real Estate Trust Conference Call.Dial in numbers: Toll Free dial in number (from Canada and USA)………..1-888-231-8191 International or Local Toronto…………………………...….1-647-427-7450Conference Call ReplayIf you cannot participate on November 13th, a replay of the conference call will be available by dialing one of the following replay numbers. You will be able to dial in and listen to the conference 120 minutes after the meeting end time, and the replay will be available until November 20, 2012.Please enter the Replay ID# 51874526, followed by the # key. Replay Dial in number (Toll Free from Canada or the USA)…………….1-855-859-2056 Local Dial-in numbers Calgary………………………………………………………………………..…403-451-9481 Vancouver........................................................................................……778-371-8506 Toronto..………………………………………………………………………....416-849-0833 Ottawa.…………………………………………………………………………...613-667-0035 Montreal………………………………………………………………………….514-807-9274 Halifax…………………………………………………………………………….902-455-3955About Pure Industrial Real Estate TrustPIRET is an unincorporated, open-ended investment trust established for the purposes of acquiring, owning and operating a diversified portfolio of income-producing industrial properties in primary markets across Canada. PIRET focuses exclusively on investing in industrial properties and is one of the largest publicly traded vehicles in Canada that offers investors exclusive exposure to Canada's industrial asset class.PIRET's units are listed on the Toronto Stock Exchange under the symbol AAR.UN. Additional information about the REIT is available at www.piret.ca or www.sedar.com.THE TORONTO STOCK EXCHANGE HAS NOT REVIEWED AND DOES NOT ACCEPT RESPONSIBILITY FOR THE ADEQUACY OR THE ACCURACY OF THIS RELEASE.SOURCE: Pure Industrial Real Estate Trust (PIRET)For further information: Andrew Greig, Director of Investor Relations Pure Industrial Real Estate Trust (PIRET) Suite 910, 925 West Georgia Street Vancouver, BC V6C 3L2 Phone: (604) 681-5959 or (888) 681-5959 E-mail: email@example.com www.piret.ca TSX - AAR.UN


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Coordinates: 54°33′50″N 6°53′31″W / 54.564°N 6.892°W
Shanmaghery or Shanmaghry (from Irish: Sean-mhachaire, meaning "old plain")[1] is a small hamlet and townland in County Tyrone, Northern Ireland, situated three miles from Pomeroy and three miles from Galbally. It is situated in the barony of Dungannon Middle and the civil parish of Pomeroy and covers an area of 426 acres.[2] Shanmaghery still remains partially an isolated area spanning one small road and several country lanes that straddle hilly countryside with excellent views of Tyrone and beyond.
The main road from Pomeroy to Dungannon which passes Shanmaghery has a classic view of Shanmaghery on a hillside. On a clear night the lights from far as Belfast can be seen. Other spectacles are the mountains of Pomeroy, Lough Neagh, and the Sperrin Mountains, where six counties can be seen on a clear day. The area consists of farming land as it may have through the centuries, mainly cattle farming. Most of the people living in the area have ancestral links going back many generations. Through the last twenty five years many changes have taken place such as the building of new homes the abandoning of old dwellings and modern farming techniques. These have changed in some forms the character of the area but culturally very little has changed. Long since dead former inhabitants are fondly remembered such as Peter McGaheys whose families lived in and around Shanmaghery probably for many generations. The crossroads below his homestead is called McGaheys Crossroads. Further up on Shanmaghery hill is another well known area called Paul's planting. Paul's Planting was harvested by local quarry men as it was disrupting their plans for rock removal with the assistance of Charlie Donnelly. When questioned by conservationists they claimed the site was of no historical significance.
In 1841 the population of the townland was 193 people (33 houses) and in 1851 it was 161 people (27 houses).[3]
Local Interest[edit]
The townland contains one Scheduled Historic Monument: Wedge tomb (grid ref: H7065 6850).[4] The stones forming the ante-chamber and burial chamber can be seen, but none of the roof lintels have survived. There is substantial cairn material and the burial chamber is filled with rubble.[5]
Lord Patsy Taig, 6th generation of the Quinn clan has a small estate and is a well known local resident.
Gortavoy Bridge[edit]
Gortavoy Bridge is a modern residential area located on the main (B43) road linking Pomeroy to Donaghmore. The local homesteads of Corrycroar and Coolmaghry are nearby. It takes its name from the local bridge. At the rear of Gortavoy Bridge the now dismantled railway line to Pomeroy is situated. A number of bridges in the area are still in use to provide access to local areas.
See also[edit]
- List of townlands of County Tyrone
- List of archaeological sites in County Tyrone
- List of villages in Northern Ireland
|Wikimedia Commons has media related to Shanmaghry.
- ^ "Shanmaghry". Place Names NI. Retrieved 23 December 2012.
- ^ "Townlands of County Tyrone". IreAtlas Townland Database. Retrieved 23 December 2012.
- ^ "Census of Ireland 1851". Enhanced Parliamentary Papers on Ireland. Retrieved 23 December 2012.
- ^ "Scheduled Historic Monuments (to 15 October 2012)" (PDF). NI Environment Agency. Retrieved 23 December 2012.
- ^ "Shanmaghry Wedge Tomb". Irish Antiquities. Retrieved 23 December 2012.


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Commonwealth of Massachusetts March 1997 Executive Office of Environmental Affairs Office of Technical Assistance (OTA) EXECUTIVE OFFICE OF ENVIRONMENTAL AFFAIRS Crest Foam Toxics Use Reduction Case Study Elimination of Methylene Chloride Use in Manufacturing Process Summary Crest Foam of Newburyport, Massachusetts recently embarked on an ambitious program to eliminate the use of volatile organic compounds (VOCs) in the firm's polyurethane foam process. The company eliminated the use of 190,000 lbs./year of methylene chloride by installing an innovative foam manufacturing process called the "Cardio Process". The Cardio Process uses CO2 instead of methylene chloride or CFC-11 as the auxiliary blowing agent. By making this change, Crest Foam avoided the need to install costly air pollution control equipment or reduce its production of foam products, either of which would have threatened the long-term survival of the facility. Background Crest Foam is a Leggett & Platt Company employing 85 people in the manufacture of flexible polyurethane foam for furniture, cushioning applications for the home, packaging and medical applications. The foam is manufactured in slabstock form via the "One Shot" process. The One Shot process is a continuous operation where all of the separate ingredients that go into the reaction for synthesizing the foam are metered to a central mixing chamber, mixed and then dispensed onto a conveyor as a froth. Because of the action of the blowing agents, the froth expands quickly to form a large bun of partially polymerized polyurethane foam. After the foam is fully expanded, the polymerization progresses in seconds to reach a fully cross-linked, solid state. In the early days of the One Shot process a common blowing agent was trichlorofluoromethane (CFC-11) which is an ozone depleting substance. It was replaced by methylene chloride, a volatile organic compound (VOC), as a result of the regulations prompted by the Montreal Protocol. The Montreal Protocol is an international agreement that called for restricted production of chlorofluorocarbons (CFCs). Methylene chloride or other volatile organics suitable to act as auxiliary blowing agents serve two purposes in the foam making process: • To act as an expanding gas to help expand the polymer mass into a matrix of open cell foam • To cool the foam during the final stages of polymerization when there is considerable heat being generated from the urethane reactions. Toxics Use Reduction Acting on the company's concerns for the environment and recommendations from the Department of Environmental Protection (DEP) to reduce VOC emissions, Crest Foam invited the Office of Technical Assistance to tour its manufacturing facility. After the tour, OTA made several suggestions for process changes that ultimately led to the elimination of methylene chloride as an auxiliary blowing agent in the foaming process. The first step was to replace the ozone depleting CFC-11 with methylene chloride as a blowing agent in their foam formulation as an intermediate step. Converting to methylene chloride was relatively simple and uninvolved. The second step was the change to the Cardio Process, which required a year of planning and $1.5 million in capital investment. This process calls for the CO2 to be injected directly into the mixing chamber along with the other ingredients. An elaborate new foam production line was needed to handle the gaseous CO2. The CO2 used in the process does not cool the reaction as methylene chloride did, therefore equipment was installed to effect cooling. Results Reductions: The elimination of methylene chloride from the foam formulation reduced Crest Foam's VOC and hazardous air pollutant emissions by 190,000 lbs/year. Further, methylene chloride is listed on EPCRA 313 as a reportable substance on EPA Form R and DEP Form S. Eliminating its use means the company no longer is subject to these reporting requirements. Economics: The planning and installation of the Cardio Process cost $1.5 million. Since CO2 is three times more efficient than methylene chloride and 80% less expensive, there was a raw material cost savings of approximately $50,000/year. But the real benefit from the installation of the new process was the elimination of the methylene chloride; if it had not been eliminated, Crest Foam would have been required to install costly air emission control equipment or reduce the type and amount of foam products it manufactures. According to Crest Foam officials, those expenses would have threatened the viability of the facility. This case study is one in a series prepared by the Office of Technical Assistance (OTA), a branch of the Massachusetts Executive Office of Environmental Affairs. OTA's mission is to assist Massachusetts facilities with reducing their use of toxic chemicals and/or the generation of toxic manufacturing byproducts. Mention of any particular equipment or proprietary technology does not represent an endorsement of these products by the Commonwealth of Massachusetts. This information is available in alternate formats upon request. OTA's non-regulatory services are available at no charge to Massachusetts businesses and institutions that use toxics. For further information about this or other case studies, or about OTA's technical assistance services, contact: Office of Technical Assistance, 251 Causeway Street, Suite 900, Boston, MA 02114-2136 Phone: (617) 626-1060 Fax: (617) 626-1095 Website: http://www.mass.gov/ota
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Aaron Bruce Smith, 39, faces a charge of sexual intercourse without consent.
According to an affidavit filed in District Court in Townsend by the Broadwater County attorney, the girl told authorities Smith entered her bedroom. Analysis showed evidence of DNA of a male at the scene, according to the affidavit.
Authorities obtained numerous warrants to obtain Smith's DNA, but each expired before they could observed. Authorities believe Smith left his employment in Broadwater County to avoid the warrants.
He formerly lived in Radersburg but has not been seen there in months and is thought to be staying in the Helena or East Helena areas, according to Broadwater County Attorney Karla Bosse.
An arrest warrant signed Jan. 29 carried a bond of $100,000.
Anyone with information on Smith should contact Capt. Nick Korthals or Undersheriff Wynn Meehan at the Broadwater County Sheriff's Office at 266-3441.
source: http://helenair.com/news/local/crime-and-courts/broadwater-man-sought-in-rape-of–year-old/article_dcf9f72c-77c2-11e2-8f20-001a4bcf887a.html#.UR-znUhbF7g.facebook


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Credits & Info
- Uploaded
- Aug 13, 2005 | 8:47 AM EDT
- Daily 2nd Place August 14, 2005
If you liked this, check these out!
Author Comments
Rated 5 / 5 stars
Great game!!
Needs medals to make it funner, like every 5-25 levels, and then like certain achievements.
All in all good game
Rated 3 / 5 stars
my computer is infected by junk mail..........nah, this is a complicated game....yet..... with a good idea
Rated 0 / 5 stars
Uhh, ok lets see her
-gun is horrible
-whats with overheating? there are more enemies coming than one can shoot off
-laser should be shooting while held down
-aim guy running at you = retarded. shouldnt be an enemy. should be an option.
-start off with a bit of health
-the upgrades are too costly. it took me to get to lvl 3 to buy something.
basically shit. work on this and make a better version
Rated 5 / 5 stars
real good game
great theme i always wanted to shoot spyware i'm at like level 20 sonthing i kik butt at pong u should make a another realy great game
Rated 0 / 5 stars
unplayable fo me!!! .no thats horrible...nice idea but shitty done....sry....
agre with spectre118


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My Account
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See how you can help the library and your community by volunteering!
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Public Feedback from Open House June 23, 2015
2015 Summer Reading Program
The Beech Grove and Indianapolis Public Libraries' Beatz & Bookz Summer Reading Program will run from June 1st to July 25th!
Read books this summer to earn points and rockin' prizes!
Tales To Tails
Our visiting Therapy Dog, Butch will be in the Library three Mondays in July starting with Monday, July 6th at 3:30pm! Sign up at the Circulation Desk if would to read to Butch!
Children's Preschool Storytime
Join Preschool Storytime for eight week Thursday morning sessions at 11am! The following is our themes for the month of July:
July 2nd On The Go At Camp
July 9th A Whale Of A Tale
July 16th Cars Zoom By!
July 23rd Crikey! We're Swamped!
Shark Week Workshop
Shark themed activities will be presented by the Teen Advisory Board on Tuesday, July 7th at 1pm! All ages are welcome!
Genealogy Research Assistance
The Samuel Bryan Chapter of the DAR will be sponsoring Genealogy Research Assistance on Monday, July 13th from 2pm-5pm and on Monday, July 27th from 4pm-7pm. Please sign up at the Circulation Desk if you plan to attend.
BG Chatterbooks Discussion Group
Join the BG Chatterbooks Discussion Group on Monday, July 13th at 6:30pm. They will be discussing short stories by J. D. Salinger and Alice Munro.
Classic Movie Night
Come see Yankee Doodle Dandy starring James Cagney on Monday, July 20th at 5:30pm.
Lapsit Storytime-For ages 0-24 months
The next lapsit program is Wednesday, July 22nd at 11am. This program is for children from birth to 24 months and their caregivers. It is an opportunity to prepare children for literacy and welcome them to the library in a safe and secure environment.
Family/All Ages Storytime
The Library has a Family/All Ages Storytime every month. Check it out on Wednesday, July 22nd at 4pm! More information can be found here!
Poetry Discussion Group
Join the Library's Poetry Discussion Group on Monday, July 27th at 6:30pm! They will be discussing Do Not Go Gently Into The Night by Dylan Thomas and Waltzing Matilda by Tom Waits.
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Honda XR400 [1997] The DirtDawg Chronicles
View Single Post
Gnarly Adventurer
Joined: Jul 2006
Location: costa mesa, ca., usa, earth, sector-28
Oddometer: 481
IMS Tank
Out riding with my step-son as he just got into riding his first motorcycle!
We where riding these thickets and he went down, so I park my bike.
More photos from that ride.
After helping Anthony get his bike up out of the bushes (i should have taken a photo of that one!) I went back to start my bike and in the soft dirt, fell over! (yes, it's a kick starter) Comedy for about 3-seconds as I looked at the bike and gas was going everywhere! I was afraid it was going to burst into flames and I would have to start the BobbyRicky dance! "Baby Jesus help me!" After my own little dance.. we laid the bike over on the side that was not leaking gas and removed the tank and did the field service repair with a tarp folded under the tank to help block the leaking. Yea, for some reason I carry a small tarp. Note to self: add plastic-weld repair kit, duct tape, electrica tape and even stickers to the backpack.
Small crack in the tank was allowing the gas to escape.
I think what has happened, due to the tank/bike sitting out in the sun [during it's dark time by the previous owner] the plastic tank has gotten brittle. Not IMS falt. I will try to fix it.
Went to Lowes and got this plastic welding stuff.
It's suppose to get about 195 degree's of heat on it to cure. I think my plastic tank is liable to melt at that point? Not sure... So a few days of the ol'light on it might work. We will see. My lazy butt needs to trot back down to Lowes and get a mini-torch.
OK, so time to repair the gas tank from the ol'trusty Honda XR400!
Conclusion: Even after getting a torch to temp the plastic repair material, it still will not seal the take! I guess it's time to bite the bullet and buy a new tank. The bike deserves it anyhow!
Nice fresh natural white IMS 4.7gallon tank - ready to serve!!!
DirtDawg is back in service!!!
While the 440 kit in the lungs is a big performance item, I feel this SCOTT Steering dampener is a must. I love it! It's my first bike with a dampener so I am rather excited about this item as it came with the bike when I purchased it.
1997 HONDA XR400 Dirt Dawg
1998 ATK 605 The ADV-Rotaxerie
2005 KTM950ADV - SOLD & Missed
GCRad1 screwed with this post 10-11-2008 at
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Embassy of Canada to Senegal
Services for Canadians
Information for Canadians travelling or living abroad. Tips on travel documents, travel health, returning to Canada and more.
Embassy of Canada
Rue Galliéni x Amadou Cissé Dia
Dakar, Senegal
Contact and office information >>
Countries of accreditation:
Senegal, Cabo Verde, Gambia, Guinea, Guinea-Bissau
Foreign Affairs, Trade and Development Canada advises against non-essential travel to Guinea, due to the Ebola outbreak, resulting movement restrictions and lowered access to quality health care.
2015-01-09 - Recruiting In-Demand, Skilled Immigrants to Canada; Express Entry will contribute to Canada's economic growth and international competitiveness
2014-12-01 - Harper Government Announces New Investment Agreements in Sub-Saharan Africa
2014-12-01 - Statement from Minister Paradis: World AIDS Day
2014-12-01 - Minister Paradis supports education and training in Senegal
- More News >>
- Date Modified:


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Courtney Harris
Strata G Ent/E1 Music
Artist: Courtney Harris
Song: Rush
When last we featured Courtney Harris, she had just signed to Koch and was ready to go public with her Grown & Sexy style. The record, however, picked up mainly negative reviews from Booth... More
Posted 6 years ago
Artist: Courtney Harris
Featuring: Keith Murray
We hear the story all the time; young female with a love for music starts singing locally, then gets discovered by a national label and rocketed to superstardom. The most recent case is that of... More
Posted 6 years ago
Sample Text - Sample Link


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News about the Collection
Featured Acquisition:
Josef Stern is the recipient of the 2014 Journal of the History of Philosophy prize for the best book in the history of philosophy published in 2013 for The Matter and Form of Maimonides' Guide (Harvard University Press).
New Acquisitions Select month, subject and area. Note, this list includes gifts to the Library.
Welcome to the Jewish Studies Guide
Image adapted from the illustration in the prospectus for the Propylaen Facsimile edition of the 15th Century Darmstadt Pessach Haggadah. Ludwig Rosenberger Library of Judaica. Special Collections Research Center, University of Chicago Library.
Use the tabs across the top of this guide to find out more about the resources we offer.
One can learn more about a resource by clicking on the blue information button .
Learn more about the Jewish Studies Collections under the "Overview of the Collection" tab above. Read the Collection Statement for Rabbinics.
Library News: Humanities & Social Sciences
Subject Specialist
Contact Info
Joseph Regenstein Library, Room 462
Send Email
Profile & Guides
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Purchase Request
The Library welcomes suggestions for the acquisition of materials which support the University's teaching and research programs.
Use this form to submit a request.
It will be routed to the appropriate subject specialist for consideration.


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Started up a new blog for dsktps this week, our first major post went live today and this was the header for it. A look back at 2012 and the most popular wallpapers of the year. Check it out!
More Jason Krieger
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