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Publications (118)312.13 Total impact
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ABSTRACT: This study investigated the interaction between polydeoxyribonucleotide (PDRN) and several ionic and nonionic isotonic agents, thickeners and a preservative that were employed as excipients in ophthalmic preparations. Interaction of each individual excipient and PDRN aqueous solution was evaluated by analyzing their rheological properties. Rheological properties of PDRN solutions were evaluated by dynamic oscillatory shear tests and values of elastic modulus (G'), viscous modulus (G″) and loss tangent (tan δ) were used to assess the relative changes in viscoelastic properties. At given concentrations, sodium chloride was found to show alteration in viscoelastic properties of PDRN solution while nonionic isotonic agents like d-glucose and d-sorbitol did not alter them. Similarly, nonionic water soluble polymers like polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC) also did not interact with PDRN to alter the viscoelastic properties. However, there were changes observed when carbopol 940 was used as a thickener. Therefore, PDRN was found to interact with ionic excipients and the interactions were negligible when nonionic materials were examined, which suggests that nonionic excipients are suitable to be formulated with PDRN.Drug Development and Industrial Pharmacy 05/2015; DOI:10.3109/03639045.2015.1040417 · 2.01 Impact Factor
Article: Serum aryl hydrocarbon receptor ligand activity is associated with insulin resistance and resulting type 2 diabetes[Show abstract] [Hide abstract]
ABSTRACT: Aims Dioxin or dioxin-like compounds are ligands of the aryl hydrocarbon receptor (AhR), which is a ligand-activated nuclear transcription factor. There are limited studies about the association of serum AhR ligand activities and T2DM. Our objective was to investigate the association of serum AhR ligand activities with T2DM and its related metabolic parameters. Methods This case-control study involved 83 subjects with T2DM as well as age-, sex-, and body mass index (BMI)-matched subjects with impaired glucose tolerance (IGT, n = 130) and normal glucose tolerance (NGT, n = 83). Serum AhR ligand activities were measured using a cell-based AhR ligand assay and standardized as 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TCDDeq, pmol/l). Results The T2DM group had the highest AhR ligand activities compared to the IGT and NGT groups [median (interquartile range), 68.1 (53.1, 81.5), 60.2 (45.8, 75.1), and 53.3 (46.1, 63.7) pmol/l, respectively; P = 0.003]. In the multivariate analysis, the log2-transformed TCDDeq levels were significantly associated with the risk of T2DM after adjusting for age, sex, and BMI (odds ratio 2.26, 95 % confidence interval 1.34-3.82; P = 0.002). In nondiabetic subjects, serum AhR ligand activities showed a positive correlation with fasting glucose and insulin concentrations and the homeostasis model assessment of insulin resistance, but showed a negative correlation with adiponectin concentrations. Conclusions Serum AhR ligand activities were higher in the T2DM group and were correlated with the parameters of insulin resistance. Further investigation is required to elucidate the causal relationship between AhR ligand activity and T2DM.Acta Diabetologica 11/2014; 52(3). DOI:10.1007/s00592-014-0674-z · 3.68 Impact Factor
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ABSTRACT: Among the various diagnostic criteria for insulinoma, the ratio criteria have been controversial. However, the amended insulin-glucose ratio exhibited excellent diagnostic performance in a recent retrospective cohort study, although it has not yet been validated in other patient cohorts. We examined the diagnostic performance of the current criteria of the Endocrine Society, insulin-glucose ratio, C-peptide-glucose ratio, and amended ratios in terms of differentiating insulinomas.07/2014; 29(4). DOI:10.3803/EnM.2014.29.4.498
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ABSTRACT: Constitutive androstane receptor (CAR) was originally identified as xenobiotic sensor that regulates the expression of cytochrome P450 genes. However, recent studies suggest that this nuclear receptor is also involved in the regulation of energy metabolism including glucose and lipid homeostasis. This study investigated the role of CAR in the regulation of bone mass in vivo using CAR(-/-) mice. Endogenous mRNA expression of CAR was observed in both primary osteoblasts and osteoclast precursors. CAR(-/-) mice have exhibited significant increase in whole body bone mineral density (BMD) by 9.5% (p < 0.01) and 5.5% (p < 0.05) at 10 and 15 weeks of age, respectively, compared with WT mice in males. Microcomputed tomography analysis of proximal tibia demonstrated a significant increase in trabecular bone volume (62.7%), trabecular number (54.1%) in male CAR(-/-) mice compared with WT mice. However, primary culture of calvarial cells exhibited no significant changes in osteogenic differentiation potential between CAR(-/-) and WT. In addition, the number of tartrate-resistant acid-phosphatase positive osteoclasts in the femur and serum level of CTx was not different between CAR(-/-) and WT mice. The higher BMD and microstructural parameters were not observed in female mice. Interestingly, serum level of testosterone in male CAR(-/-) mice was 2.5-fold higher compared with WT mice and the mRNA expressions of Cyp2b9 and 2b10 in the liver, which regulate testosterone metabolism, were significantly down-regulated in male CAR(-/-) mice. Furthermore, the difference in BMD between CAR(-/-) and WT mice disappeared at 8 weeks after performing orchiectomy. CAR(-/-) mice also exhibited significant increase in serum1,25(OH)2 D3 levels but Cyp 27B1 which converts 25(OH)D3 to 1,25(OH)2 D3 was significantly down-regulated compared to WT mice. These results suggest that in vivo deletion of CAR resulted in higher bone mass, which appears to be a result from reduced metabolism of testosterone due to down-regulation of Cyp2b. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc.Journal of Cellular Physiology 05/2014; 229(5). DOI:10.1002/jcp.24478 · 3.87 Impact Factor
Article: Changes of MicroRNA Profile and MicroRNA-mRNA Regulatory Network in Bones of Ovariectomized Mice[Show abstract] [Hide abstract]
ABSTRACT: Growing evidence shows the possibility of role of microRNAs (miRNA) in regulating bone mass. We investigated the change of miRNAs and mRNA expression profiles in bone tissue in ovariectomized mice model and evaluated regulatory mechanism of bone mass mediated by miRNAs in estrogen deficiency state. Eight-week old female C3H/HeJ mice underwent ovariectomy (OVX) or sham operation (Sham-op) and their femur and tibia were harvested to extract total bone RNAs after 4 weeks for microarray analysis. Eight miRNAs (miR-127, -133a, -133a*, -133b, -136 -206, -378, -378*) were identified to be upregulated after OVX while one miRNA (miR-204) was downregulated. Concomitant analysis of mRNA microarray revealed that 658 genes were differentially expressed between OVX and Sham-op mice. Target prediction of differentially expressed miRNAs identified potential targets and integrative analysis using the mRNA microarray results showed that PPARγ and CREB pathways are activated in skeletal tissues after ovariectomy. Among the potential candidates of miRNA, we further studied the role of miR-127 in vitro, which exhibited the greatest changes after OVX. We also studied the effects of miR-136, which has not been studied in the context of bone mass regulation. Transfection of miR-127 inhibitor has enhanced osteoblastic differentiation in UAMS-32 cells as measured by alkaline phosphatase activities and mRNA expression of osteoblast-specific genes while miR-136 precursor has inhibited osteoblastic differentiation. Furthermore, transfection of both miR-127 and miR-136 inhibitors enhanced the osteocyte-like morphological changes and survival in MLO-Y4 cells while precursors of miR-127 and -136 has aggravated dexamethasone-induced cell death. Both of the precursors enhanced osteoclastic differentiation in bone marrow macrophages, indicating that both miR-127 and -136 are negatively regulating bone mass. Taken together, these results suggest a novel insight into the association between distinct miRNAs expression and their possible role through regulatory network with mRNAs in the pathogenesis of estrogen deficiency induced osteoporosis.Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 03/2014; 29(3). DOI:10.1002/jbmr.2060 · 6.59 Impact Factor
Article: Different cut-off values of the insulin tolerance test, the high dose short Synacthen test (250 μg) and the low dose short Synacthen test (1 μg) in assessing central adrenal insufficiency.[Show abstract] [Hide abstract]
ABSTRACT: The short Synacthen test (SST) is widely used as alternative test to the insulin tolerance test (ITT) to investigate central adrenal insufficiency (CAI), but the methodology and cut-off values of the SST are controversial. Our aim was to evaluate the cut-off value of the ITT in normal subjects and to assess the different cutoff values of the high-dose SST (250 μg, HDT) and the low-dose SST (1 μg, LDT) in subjects with suspected CAI SUBJECTS AND METHODS: We conducted ITTs in 208 normal subjects to establish the cut-off value for the ITT, and 28 of those subjects underwent the HDT and LDT. From 1999 to 2007, 182 patients with suspected CAI were recruited and underwent ITTs, LDTs and HDTs to establish cut-off values and compare the diagnostic accuracy between the LDT and HDT. The 95(th) percentile of the peak cortisol level during the ITT in the normal control subjects was 14.8 μg/dl. Receiver-operator characteristics (ROC) analysis revealed that the optimal cut-off values of peak cortisol in the LDT and HDT in patients with suspected CAI were 15.8 and 17.4 μg/dl, respectively. However, the cut-off values from normative data (mean-2SD) were 18.3 μg/dl for the LDT and 20.5 μg/dl for the HDT in normal control. The optimal cut-off values of SSTs needed to be individualized according to the type of SST and tested patient population. This article is protected by copyright. All rights reserved.Clinical Endocrinology 01/2014; 81(1). DOI:10.1111/cen.12397 · 3.35 Impact Factor
Article: A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation.[Show abstract] [Hide abstract]
ABSTRACT: 17α-hydroxylase/17,20-lyase deficiency is a rare form of congenital adrenal hyperplasia, characterized by hypertension and sexual infantilism and caused by loss-of-function mutations in CYP17A1. This study investigated the clinical and molecular characteristics of six adults with 17α-hydroxylase/17,20-lyase deficiency and the functional consequences of a novel CYP17A1 mutation. Six phenotypic females, three with 46,XY and three with 46,XX karyotypes, presented with primary amenorrhea and hypertension. All had elevated levels of plasma adrenocorticotropic hormone, serum gonadotropin, progesterone, and 11-deoxycorticosterone, and reduced testosterone and dehydroepiandrosterone sulfate (DHEA-S). All coding exons and flanking intronic sequences of CYP17A1 were directly sequenced using genomic DNA. Wild-type and mutant CYP17A1 cDNAs were inserted into the pcDNA3.1/V5-His-P450c17 vector, and transiently expressed in COS-7 cells. This was followed by an assessment of 17α-hydroxylase and 17,20-lyase activities by measuring the conversions of progesterone to 17-hydroxyprogesterone and 17-hydroxypregnenolone to DHEA. The mutation analysis identified one patient with compound heterozygosity for p.H373L and p.W406L, one with compound heterozygosity for p.H373L and p.A174E, three with compound heterozygosity for p.Y329fs and p.H373L, and one with homozygosity for p.H373L. An in vitro functional analysis of the novel p.W406L mutation revealed a complete loss of 17α-hydroxylase/17, 20-lyase activities. p.H373L was the most common mutation among these Korean patients, consistent with the high allele frequency of p.H373L in Chinese and Japanese populations, suggesting possible founder effects in Asian countries. The novel p.W406L mutation caused a complete loss of both catalytic activities, indicating that this amino acid is critical for P450c17 function.Metabolism: clinical and experimental 10/2013; DOI:10.1016/j.metabol.2013.08.015 · 3.61 Impact Factor
Article: Germline mutations and genotype-phenotype correlations in patients with apparently sporadic pheochromocytoma/paraganglioma in Korea[Show abstract] [Hide abstract]
ABSTRACT: The aim of our study was to assess the frequency of germline mutations and develop the genetic testing strategy in patients with apparently sporadic pheochromocytoma/paraganglioma (PPGL) in Korea. We included 53 patients diagnosed with nonsyndromic PPGL without a family history of PPGLs in three referral centers from 2004 to 2011. Succinate dehydrogenase complex B (SDHB), succinate dehydrogenase complex D (SDHD), Von Hippel-Lindau (VHL), and RET genes were examined by direct sequencing and multiple ligation-dependent probe amplification. The study patients were composed of 26 men and 27 women, and mean age was 50.1 ± 13.5 years. The frequency of germline mutations was 13.2% (7/53): RET (n =2), VHL (n = 1), SDHB (n = 2), SDHD (n = 2). Six of seven mutation carriers were diagnosed before the age of 50 years. One of two patients harboring an SDHB mutation had malignant PPGLs. One patient with multifocal head and neck PGL and PHEO carried a SDHD mutation. The carriers of germline mutations in patients with apparently sporadic PPGL were 13.2% in our study. We recommend genetic testing in patients under 50 years and SDHD genetic testing in patients with multifocal PPGLs. In malignant PPGLs, SDHB genetic testing may be performed.Clinical Genetics 10/2013; 86(5). DOI:10.1111/cge.12304 · 3.65 Impact Factor
Article: Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score[Show abstract] [Hide abstract]
ABSTRACT: Women with a history of gestational diabetes mellitus (GDM) are at increased risk of future development of type 2 diabetes. Recently, over 65 genetic variants have been confirmed to be associated with diabetes. We investigated whether this genetic information could improve the prediction of future diabetes in women with GDM. This was a prospective cohort study consisting of 395 women with GDM who were followed annually with an OGTT. A weighted genetic risk score (wGRS), consisting of 48 variants, was assessed for improving discrimination (C statistic) and risk reclassification (continuous net reclassification improvement [NRI] index) when added to clinical risk factors. Among the 395 women with GDM, 116 (29.4%) developed diabetes during a median follow-up period of 45 months. Women with GDM who went on to develop diabetes had a significantly higher wGRS than those who did not (9.36 ± 0.92 vs 8.78 ± 1.07; p < 1.56 × 10(-7)). In a complex clinical model adjusted for age, prepregnancy BMI, family history of diabetes, blood pressure, fasting glucose and fasting insulin concentration, the C statistic marginally improved from 0.741 without the wGRS to 0.775 with the wGRS (p = 0.015). The addition of the wGRS to the clinical model resulted in a modest improvement in reclassification (continuous NRI 0.430 [95% CI 0.218, 0.642]; p = 7.0 × 10(-5)). In women with GDM, who are at high risk of diabetes, the wGRS was significantly associated with the future development of diabetes. Furthermore, it improved prediction over clinical risk factors.Diabetologia 09/2013; 56(12). DOI:10.1007/s00125-013-3059-x · 6.88 Impact Factor
Article: Chronic Central Administration of Ghrelin Increases Bone Mass through a Mechanism Independent of Appetite Regulation[Show abstract] [Hide abstract]
ABSTRACT: Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21 days). Rats were divided into control, ghrelin ad libitum-fed (ghrelin ad lib-fed), and ghrelin pair-fed groups. Ghrelin intracerebroventricular infusion significantly increased body weight in ghrelin ad lib-fed rats but not in ghrelin pair-fed rats, as compared with control rats. Chronic intracerebroventricular ghrelin infusion significantly increased bone mass in the ghrelin pair-fed group compared with control as indicated by increased bone volume percentage, trabecular thickness, trabecular number and volumetric bone mineral density in tibia trabecular bone. There was no significant difference in trabecular bone mass between the control group and the ghrelin ad-lib fed group. Chronic intracerebroventricular ghrelin infusion significantly increased the mineral apposition rate in the ghrelin pair-fed group as compared with control. In conclusion, chronic central administration of ghrelin increases bone mass through a mechanism that is independent of body weight, suggesting that ghrelin may have a bone anabolic effect through the central nervous system.PLoS ONE 07/2013; 8(7):e65505. DOI:10.1371/journal.pone.0065505 · 3.53 Impact Factor
Article: Effect of Seasonal Changes on the Transition Between Subclinical Hypothyroid and Euthyroid Status[Show abstract] [Hide abstract]
ABSTRACT: Context:The widespread use of thyroid tests in asymptomatic individuals identifies many patients with transient subclinical hypothyroidism.Objective:To determine the effect of seasonal change on serum TSH levels and the transition between subclinical hypothyroid and euthyroid status.Design, Setting, and Subjects:This was a retrospective longitudinal study of 1751 subclinical hypothyroid and 28096 euthyroid subjects aged over 18 years who underwent serial thyroid function tests at a health screening center between October 2003 and May 2011. Main Outcome Measures:Age-adjusted geometric mean values of the TSH level by month were calculated using linear mixed models. Adjusted odds ratios of test season and multiple baseline clinical factors were determined using generalized estimating equations.Results:During median 36 months of follow-up, 57.9% of subclinical hypothyroid subjects reverted to euthyroidism, and 4.3% of euthyroid subjects developed subclinical hypothyroidism. The monthly distribution of follow-up TSH levels indicated a biphasic pattern, i.e., an increase during the winter-spring season and a decrease during the summer-fall season, with a maximal TSH difference of 0.69 mIU/L in subclinical hypothyroid and 0.30 mIU/L in euthyroid subjects. Normalization of subclinical hypothyroidism was increased 1.4-fold in follow-up tests during the summer-fall follow-up, whereas subclinical hypothyroidism increased 1.4-fold in euthyroid subjects during the winter-spring follow-up.Conclusions:The season in which thyroid testing was performed was independently related to the transition between subclinical hypothyroid and euthyroid status. Seasonal variations in TSH concentration should be considered before deciding on treatment of subclinical hypothyroidism, particularly in the areas with a wide annual temperature range.The Journal of Clinical Endocrinology and Metabolism 06/2013; 98(8). DOI:10.1210/jc.2013-1607 · 6.31 Impact Factor
Article: Clinical Characteristics of the Responders to Dipeptidyl Peptidase-4 Inhibitors in Korean Subjects with Type 2 Diabetes[Show abstract] [Hide abstract]
ABSTRACT: We investigated characteristics associated with the efficacy of dipeptidyl peptidase-4 inhibitors (DPP4i) in Korean patients with type 2 diabetes. We reviewed medical records of 477 patients who had taken sitagliptin or vildagliptin longer than 40 weeks. Response to DPP4i was evaluated with HbA1c change after therapy (ΔHbA1c). The Student's t-test between good responders (GR: ΔHbA1c > 1.0%) and poor responders (PR: ΔHbA1c < 0.5%), a correlation analysis among clinical parameters, and a linear multivariate regression analysis were performed. The mean age was 60 yr, duration of diabetes 11 yr and HbA1c was 8.1%. Baseline fasting plasma glucose (FPG), HbA1c, C-peptide, and creatinine were significantly higher in the GR compared to the PR. Duration of diabetes, FPG, HbA1c, C-peptide and creatinine were significantly correlated with ΔHbA1c. In the multivariate analysis, age (r(2) = 0.006), duration of diabetes (r(2) = 0.019), HbA1c (r(2) = 0.296), and creatinine levels (r(2) = 0.024) were independent predictors for the response to DPP4i. Body mass index and insulin resistance were not associated with the response to DPP4i. In conclusion, better response to DPP4i would be expected in Korean patients with type 2 diabetes who have higher baseline HbA1c and creatinine levels with shorter duration of diabetes.Journal of Korean medical science 06/2013; 28(6):881-7. DOI:10.3346/jkms.2013.28.6.881 · 1.25 Impact Factor
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ABSTRACT: Farnesoid X receptor (FXR) is a nuclear receptor, which functions as a bile acid sensor controlling bile acid homeostasis. We investigated the role of FXR in regulating bone metabolism. We identified the expression of FXR in calvaria and bone marrow cells, which gradually increased during osteoblastic differentiation in vitro. In male mice, deletion of FXR (FXR(-/-) ) in vivo resulted in a significant reduction in bone mineral density by 4.3∼6.6% in mice 8 to 20 weeks of age compared with FXR(+/+) mice. Histological analysis of the lumbar spine showed that FXR deficiency reduced the bone formation rate as well as the trabecular bone volume and thickness. Moreover, TRACP staining of the femurs revealed that both the osteoclast number and osteoclast surface were significantly increased in FXR(-/-) mice compared with FXR(+/+) mice. At the cellular level, induction of alkaline phosphatase (ALP) activities was blunted in primary calvarial cells in FXR(-/-) mice compared with FXR(+/+) mice in concert with a significant reduction in Col1a1, ALP, and Runx2 gene expressions. Cultures of bone marrow derived macrophages from FXR(-/-) mice exhibited an increased number of osteoclast formations and protein expression of NFATc1. In female FXR(-/-) mice, although BMD was not significantly different from that in FXR(+/+) mice, bone loss was accelerated after an ovariectomy compared with FXR(+/+) mice. In vitro, activation of FXR by bile acids (CDCA or 6-ECDCA) or FXR agonists (GW4064 or Fexaramine) significantly enhanced osteoblastic differentiation through the upregulation of Runx2 and enhanced ERK and β-catenin signaling. FXR agonists also suppressed osteoclast differentiation from bone marrow macrophages. Finally, administration of a farnesol diet (1%) marginally prevented OVX-induced bone loss and enhanced bone mass gain in growing C57BL/6J mice. Taken together, these results suggest that FXR positively regulates bone metabolism through both arms of the bone remodeling pathways, i.e. bone formation and resorption.Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 05/2013; 28(10). DOI:10.1002/jbmr.1961 · 6.59 Impact Factor
Article: Clinical and Genetic Risk Factors for Type 2 Diabetes at Early or Late Post Partum After Gestational Diabetes Mellitus[Show abstract] [Hide abstract]
ABSTRACT: Context:Women with a history of gestational diabetes mellitus (GDM) are at increased risk of type 2 diabetes (T2DM). However, the time to progression to diabetes differs individually.Objective:We investigated the clinical and genetic risk factors that are associated with T2DM early or late post partum after GDM pregnancy.Design and Setting:This was a hospital-based prospective cohort study that enrolled GDM women.Patients and Outcome Measures:A total of 843 GDM subjects were followed for the development of T2DM. Clinical risk factors were investigated during pregnancy, 2 months post partum, and annually thereafter. GDM subjects were genotyped for 21 known T2DM-associated genetic variants, and their genotype frequencies were compared with elderly nondiabetic controls.Results:At 2 months post partum, 105 (12.5%) subjects had T2DM (early converters). Among the 370 remaining subjects who underwent more than 1 year of follow-up, 88 (23.8%) had newly developed T2DM (late converters). Independent risk factors for early converters were higher prepregnancy body mass index, higher area under the curve of glucose during an antepartum oral glucose tolerance test, lower fasting insulin concentration, and decreased β-cell function. Independent risk factors for late converters were higher prepregnancy body mass index and higher glucose area under the curve. Variants in CDKN2A/2B and HHEX were associated with early conversion, whereas variants in CDKAL1 were associated with late conversion.Conclusions:Obesity was a risk factor for both early and late T2DM converters. However, early converters had more pronounced defects in β-cell function, which might be explained, in part, by differences in genetic predisposition.The Journal of Clinical Endocrinology and Metabolism 03/2013; 98(4). DOI:10.1210/jc.2012-3324 · 6.31 Impact Factor
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ABSTRACT: We report here the cases of two females with Graves' disease who developed insulin autoimmune syndrome after treatment with methimazole. The patients exhibited a sudden altered mental state after treatment with methimazole for approximately 4 weeks. Patients had hypoglycemia with serum glucose below 70 mg/dL, and laboratory findings showed both high levels of serum insulin and high titers of insulin autoantibodies. The two women had never been exposed to insulin or oral antidiabetic agents, and there was no evidence of insulinoma in imaging studies. After glucose loading, serum glucose, and total insulin levels increased abnormally. One of the patient was found to have HLA-DRB1*0406, which is known to be strongly associated with methimazole-induced insulin autoimmune syndrome. After discontinuation of methimazole, hypoglycemic events disappeared within 1 month. Insulin autoantibody titer and insulin levels decreased within 5 months and there was no further development of hypoglycemic events. We present these cases with a review of the relevant literature.03/2013; 28(1):55-60. DOI:10.3803/EnM.2013.28.1.55
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ABSTRACT: Osteoblasts are derived from mesenchymal progenitors. Differentiation to osteoblasts and adipocytes is reciprocally regulated. Transcriptional coactivator with a PDZ-binding motif (TAZ) is a transcriptional coactivator that induces differentiation of mesenchymal cells into osteoblasts while blocking differentiation into adipocytes. To investigate the role of TAZ on bone metabolism in vivo, we generated transgenic mice that overexpress TAZ under the control of the procollagen type 1 promoter (Col1-TAZ). Whole body bone mineral density (BMD) of 6- to 19-week-old Col-TAZ mice was 4% to 7% higher than that of their wild-type (WT) littermates, whereas no difference was noticed in Col.1-TAZ female mice. Microcomputed tomography analyses of proximal tibiae at 16 weeks of age demonstrated a significant increase in trabecular bone volume (26.7%) and trabecular number (26.6%) with a reciprocal decrease in trabecular spacing (14.2%) in Col1-TAZ mice compared with their WT littermates. In addition, dynamic histomorphometric analysis of the lumbar spine revealed increased mineral apposition rate (42.8%) and the serum P1NP level was also significantly increased (53%) in Col.1-TAZ mice. When primary calvaria cells were cultured in osteogenic medium, alkaline phosphatase (ALP) activity was significantly increased and adipogenesis was significantly suppressed in Col1-TAZ mice compared with their WT littermates. Quantitative real-time polymerase chain reaction analyses showed that expression of collagen type 1, bone sialoprotein, osteocalcin, ALP, osterix, and Runx2 was significantly increased in calvaria cells from Col1-TAZ mice compared to their WT littermates. In vitro, TAZ enhanced Runx2-mediated transcriptional activity while suppressing the peroxisome proliferator-activated receptor gamma signaling pathway. TAZ also enhanced transcriptional activity from 3TP-Lux, which reflects transforming growth factor-beta (TGF-β)-mediated signaling. In addition, TAZ enhanced TGF-β-dependent nuclear translocation of Smad2/3 and Smad4. Taken together, these results suggest that TAZ positively regulates bone formation in vivo, which seems to be mediated by enhancing both Runx2 and TGF-β signaling.PLoS ONE 02/2013; 8(2):e56585. DOI:10.1371/journal.pone.0056585 · 3.53 Impact Factor
Article: Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats[Show abstract] [Hide abstract]
ABSTRACT: The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.Korean Journal of Physiology and Pharmacology 02/2013; 17(1):9-13. DOI:10.4196/kjpp.2013.17.1.9 · 1.26 Impact Factor
Article: Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells or Their Conditioned Medium Prevents Bone Loss in Ovariectomized Nude Mice[Show abstract] [Hide abstract]
ABSTRACT: Umbilical cord blood (UCB) has recently been recognized as a new source of mesenchymal stem cells (MSCs) for use in stem cell therapy. We studied the effects of systemic injection of human UCB-MSCs and their conditioned medium (CM) on ovariectomy (OVX)-induced bone loss in nude mice. Ten-week-old female nude mice were divided into six groups: Sham-operated mice treated with vehicle (Sham-Vehicle), OVX mice subjected to UCB-MSCs (OVX-MSC) or human dermal fibroblasts (OVX-DFB) transplantation, OVX mice treated with UCB-MSCs CM (OVX-CM), zoledronate (OVX-Zol), or vehicle (OVX-Vehicle). Although OVX-Vehicle group exhibited significantly less bone mineral density (BMD) gain compared with Sham-Vehicle group, transplantation of hUCB-MSCs (OVX-MSC group) has effectively prevented OVX-induced bone mass attenuation. Notably, OVX-CM group also showed BMD preservation comparable to the OVX-MSC group. In addition, micro-CT analysis demonstrated improved trabecular parameters in both OVX-MSC and OVX-CM groups compared to OVX-Vehicle or OVX-DFB group. Histomorphometric analysis showed increased bone formation parameters, accompanied by increased serum procollagen type-I N-telopeptide levels in OVX-MSC and OVX-CM mice. However, cell trafficking analysis failed to demonstrate engraftment of MSCs in bone tissue 48 hrs after cell infusion. In vitro, hUCB-MSC CM increased alkaline phosphatase activity in human bone marrow-derived MSCs and mRNA expression of collagen type 1, Runx2, osterix, and alkaline phosphatase in C3H10T1/2 cells. Furthermore, hUCB-MSC CM significantly increased survival of osteocyte-like MLO-Y4 cells while it inhibited osteoclastic differentiation. To summarize, transplantation of hUCB-MSCs could effectively prevented OVX-mediated bone loss in nude mice which appears to be mediated by paracrine mechanism rather than direct engraftment of the MSCs.Tissue Engineering Part A 12/2012; 19(5-6). DOI:10.1089/ten.TEA.2012.0047 · 4.64 Impact Factor
Article: Development of self-microemulsifying bilayer tablets for pH-independent fast release of candesartan cilexetil[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to design self-microemulsifying tablets for pH-independent fast release of poorly soluble candesartan cilexetil (CDC). To improve the solubility of CDC, a self-microemulsifying drug delivery system (SMEDDS) was prepared composed of Capryol 90, Tween 80 and tetraglycol at a ratio of 5:35:60. Drug containing SMEDDS was adsorbed onto Fujicalin and Neusilin UFL2, respectively, used as solidification carriers and subsequently compressed into tablets (self-microemulsifying tablet, SMET). SMET using Fujicalin exhibited immediate CDC release in pH 1.2 medium while Neusilin UFL2-based SMET showed fast release, especially at pH 6.5. Thus, optimized SMET could be produced with one layer of Fujicalin and the other layer with Neusilin UFL2, demonstrating CDC release of 75% of the initial dose within 15 min in all pH conditions (1.2, 4.5, and 6.5). The average diameter of emulsion droplets formed from SMET was less than 200 nm. It was thus expected that Fujicalin and Neusilin UFL2-based bi-layer SMET would overcome low oral bioavailability of CDC due to its limited solubility at physiological pH conditions in the gastrointestinal tract.Pharmazie 11/2012; 67(11):917-24. DOI:10.1691/ph.2012.2003 · 1.00 Impact Factor
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ABSTRACT: CONTEXT: It was previously reported in Korea that there were 1.4 case per million per year of acromogly. This was low in comparison to the extrapolated values of western European countries. We expected that the incidence of acromegaly would be much higher now due to recently improved medical facilities, diagnostic tools, and coverage of medical insurance to all the population of South Korea. OBJECTIVE: The purpose of this nationwide survey was to examine the incidence and prevalence of acromegaly patients, mode of treatment, and outcome of surgical treatment of recent 5 years. DESIGN AND PATIENTS: We requested and collected the medical records of all possible acromegaly patients from 74 secondary or tertiary medical institutes in Korea from 2003 to 2007 retrospectively. MEASUREMENTS: Date of diagnosis and treatment, tumor size, pre- and postoperative hormonal level, treatment modality and usage of medication were collected. RESULTS: During 5 years, 1350 acromegaly patients had been registered. The average annual incidence was 3.9 cases per million during this period, and prevalence had increased up to 27.9 cases per million in 2007. Male:female ratio was 1:1.2, and mean age at diagnosis was 44.1 years. Macroadenoma was dominant (82.9%). Transsphenoidal adenoidectomy was used the most as primary treatment (90.4%). CONCLUSIONS: This Korean acromegaly survey offers a realistic overview of the predominant epidemiological characteristics of acromegaly in Korea. Annual incidence was at a similar level with western countries. Efforts to diagnose and control the disease earlier are recommended. © 2012 Blackwell Publishing Ltd.Clinical Endocrinology 08/2012; 78(4). DOI:10.1111/cen.12020 · 3.35 Impact Factor
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|Advertise On UGHH
IM King (The Faith): FaithDark BlueT-Shirt
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Product Details
SummaryInspired by the band "The Faith" that lead singer Alec Mackaye, formally from the "Untouchables", founded in the early 80's. A tribute to the early Washington D.C. hardcore scene that birthed some of the most influential bands of all time.
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text: Josh Young, Chuck Cooper and Erin Mackey star in Amazing Grace, the new Broadway musical which tells the true story of Englishman John Newton, a former slave trader who wrote the beloved titular hymn. The cast met the press at 54 Below to run through several tunes from the Arthur Giron (book) and Christopher Smith (music, lyrics, book) show. Performances begins June 25. See show details.


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$6M donation to food banks
Stop ... Shop announced it would donate $6 million to food banks to fight childhood hunger, $600,000 of which it will donate to Island Harvest and Long Island Cares. Lynbrook North and South High schools will compete to see which will hold the most successful drive. Videojournalist: Brittany Wait (Feb. 20, 2013)
New LIRR cars short on space for crash technology Pedestrian dies after being struck by SUV on Route 111, police say Woman dies in Deer Park house fire Tall Ships arrive for festival in Greenport Summertime is here Working on the atomic bomb Suffolk cops demonstrate dangers of illegal fireworks Fire Island resort fire Extraordinary Seniors: Yaakov Kaminetsky Forecast: Partly sunny for July Fourth Thursday's puppy of the Day: Bruno Drag show at Cherry's On The Bay


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There are 33 results - Show results on a map Print this page
Showing 21 - 30 of 33
A haven for cat lovers, Fluxton Farm offers comfortable accommodation with a choice of lounges and a large garden, complete with pond and ducks. Set in peaceful farmland four miles from the coast, thi...More about Fluxton Farm
Quietly located between the River Otter and its millstream, and set in well-tended gardens, this family-run hotel offers friendly and attentive service. Bedrooms are attractively presented and equippe...More about Tumbling Weir Hotel
Set in three acres of attractive and well-tended grounds, Hunters Moon Hotel is a friendly, family-run establishment located in a quiet area within walking distance of the town and esplanade. The ligh...More about Hunters Moon Hotel
The Devoncourt stands in four acres of mature, subtropical gardens, sloping gently towards the sea and overlooking two miles of sandy beaches. It offers extensive leisure facilities, and the smartly f...More about The Devoncourt
Conveniently situated a short, level walking distance from the town centre, The Groveside offers boutique-style accommodation. A number of influences, such as art deco, have been used to impressive ef...More about The Groveside
Located just yards from the beach and cliff paths, this comfortable establishment has a friendly and relaxed atmosphere. Bedrooms, some with sea views, are well equipped, and public rooms are light an...More about Mariners
This charming hotel is ideally located within walking distance of Sidmouth's elegant promenade and beaches. The spacious lounges and the cocktail bar open onto a terrace which leads to the pool and cr...More about Sidmouth Harbour Hotel
A family-owned and run hotel, the Langstone Cliff Hotel offers a range of leisure, conference and function facilities. Bedrooms, many with sea views and balconies, are spacious, comfortable and well e...More about Langstone Cliff Hotel
Prominently positioned on the seafront just a few minutes' walk from the town centre, this traditional hotel has many returning guests. A choice of comfortable lounges provides ample space for relaxat...More about The Belmont Hotel
Overlooking the sea and close to the town centre, the Riviera is a fine example of Regency architecture. The large number of guests that become regular visitors here are testament to the high standard...More about Hotel Riviera


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22-15485 - 8" Cable Cutter
Made of drop forged, heat treated fully polished steel, these cable cutters can cut through a variety of cable types. Soft grip handles for user comfort.
Mfr Name: Duratool
Mfr Number: D02159
22-14428 - 10" Cable Cutting Pliers
These cable cutting pliers can be used for cutting vinyl coated copper or aluminum cable. Made from high grade steel with blue PVC vinyl grips.
Mfr Number: DCC-10A
22-14466 - 6.3" Professonal Cable Cutters
Professional style cable cutters feature a shock proof, 2-component handle with slip guard for safety. Made of drop forged, heat treated fully polished steel.
Mfr Number: D00628
22-23945 - Stainless Steel Cable Cutter
These cutter feature sharp, rounded blades provide a clean cut without distortion to cable shape and dialectic
Mfr Name: Distributed By MCM
Mfr Number: 22-23945
22-15185 - Compound Action Cable Cutter with Holster
Used for cutting copper and aluminum electric cable up to 2AWG or 1/2" in diameter. Features a spring-free automatic latch design for one hand release. Compound leverage increases cutting power.
Mfr Name: Titan
Mfr Number: 11470
22-14468 - 8.3" Professional Cable Cutters
Mfr Number: D00629
22-3520 - Cable Cutting Pliers
Designed to cut 4/0 aluminum and up to 2/0 soft copper Extra long handles provide maximum cutting leverage and gripping strength Designed for minimum cable distortion An excellent all purpose plier Overall length: 91/2"
Mfr Name: Grip Tools
Mfr Number: 57455
22-9608 - High-Leverage Cable Cutter 9-1/2" Red
High-leverage design for exceptional cutting capability.Precision, one-hand shearing action.Cable-gripping shear-type jaws.Perfect for working in confined spaces.Can be carried in most tool pouches.Hot-riveted joint ensures smooth action and no handle wobble.Bevel...
Mfr Name: Klein Tools
Mfr Number: 63050
22-24335 - BTC-20 (2/0) Heavy Cable Cutter
This high leverage, heavy duty, chrome vanadium cable cutter is built to last and is a must for any tool belt!
Mfr Name: Platinum Tools
Mfr Number: 10540C
22-10795 - Steel Wire Cutter
Heavy duty, high leverage design provides singlehanded cutting action Smooth spring action for easy, repetitive cutting li>Maintains concentricity to allow fittings and terminals to go on easily Mfg# 10512
Mfr Number: 10512C
22-24375 - Coax & Round Wire Cable Cutter
This durable, economically priced cutter is designed to cut solid and stranded wire to 8 AWG, multi-conductor and coaxial cable to 1/2" diameter. Features a curved, precision ground cutting blade that will not deform the conductors or dielectric you are cutting.
Mfr Number: 10500C
22-14424 - 6" Cable Cutting Pliers
Mfr Number: DCC-6A
22-14426 - 8" Cable Cutting Pliers
Mfr Number: DCC-8A
22-9532 - Klein Kurve Multi-Cable Cutter, 7", Cushioned Handle
Hardened steel precision-ground cutting blades for long life.Copper curved cutter cleanly cuts round copper cable without compression or frayed ends.Anvil cutter for solid and stranded copper wire up to 12 AWG and stainless steel up to .032 '' (2 mm) diame...
Mfr Number: 63020
22-17140 - 5" Wire Cutters
Overall Length: 5"
Cutter Type: Micro Bevel
Cutting Capacity Max: 2mm
Mfr Number: L8160
Quick shipping, quality products and reasonable prices. I've redone most of my home with MCM products. Very pleased.


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Obituaries 08.18.2014
COASTAL BEND - The news department publishes obituaries free of charge on a space-available basis as a service to Caller-Times readers. Only obituaries from funeral homes are accepted.
Marlon D. Atwood Sr.
SANDIA — Marlon D. "Cotton" Atwood Sr. died Aug. 14, 2014. He was 82.
Services will be at 10 a.m. Aug. 19 at Sawyer-George Funeral Home Chapel. Burial will follow in Memorial Park Cemetery.
Alejandra L. Cruz
TAFT — Alejandra L. Cruz died Aug. 14, 2014. She was 88.
Mass will be celebrated at 10 a.m. Aug. 18 at Immaculate Conception Catholic Church. Burial will follow in The Palms Memorial Gardens, Portland.
Colonial Funeral Home
Tyler L. Doramus
Tyler Lee Tot Barrett Doramus died Aug. 15, 2014. She was 91.
Services will be at 10 a.m. Aug. 19 at Seaside Funeral Home Chapel. Burial will follow in Seaside Memorial Park.
Susan Lemar
Susan Lemar died Aug. 15, 2014. She was 63.
Services will be private.
Guardian Funeral Home
Juan G. Morin
SINTON — Juan Garcia Morin died Aug. 15,2014. He was 73.
Mass will be celebrated at 9 a.m. Aug. 18 at Our Lady of Guadalupe Catholic Church. Burial will follow in Eternal Rest Cemetery.
Ritchea-Gonzales Funeral Home
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Congress passed, and the President has signed into law, the VOW to Hire Heroes Act of 2011. Included in this new law is the Veterans Retraining Assistance Program (VRAP). VRAP offers up to 12 months of training assistance to unemployed Veterans. The Department of Veteran Affairs (VA) and the Department of Labor (DOL) are working together to roll out this new program on July 1, 2012.
The VRAP offers 12 months of training assistance to Veterans who:
ŌĆó Are at least 35 but no more than 60 years old;
ŌĆó Are unemployed;
ŌĆó Received an other than dishonorable discharge;
First Baptist Church saddles up for Vacation Bible School, June 4 through the 7, from 6-8 p.m. The first three nights will be held at First Baptist Church, (213 E. 3rd) beginning each evening in the church sanctuary for a round-up. Then they will travel along the Tejas Trail to snacks, recreation, crafts and Bible stories.
Tina Melendez was given the honor of being named the 2011-12 SHS (Sweetwater High School) Teacher of the Year within the Sweetwater Independent School District.
Melendez is a 9th-12th grade Spanish II teacher at SHS. Out of her eight total years of teaching, six of those have been with Sweetwater ISD. She earned her Bachelor of Science degree from McMurry University.
The Sweetwater High School FFA Career Development teams were honored with a resolution during the May meeting of the SISD Board of Trustees. The teams qualified for state in Cotton Judging, Homesite Evaluation, Meats Judging, Milk Quality and Products Judging, Poultry Judging and Wool Judging.


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Why does he call me babe?
I have a friend, and I've noticed that he calls me babe now. I think he started a few weeks ago. It started around the time I told him he was my fake... Show More
What Guys Said 2
he wants you to be his girlfriend, he might be scared or shy. you just need to break that 'shy wall' so that he could be more confident to tell you how much he loves you :)
Idk what to do though to like get his attention, I like him a lot and I wanna be with him. He said he was shaking when he asked me out and he gets too nervous.. How do I get him not so nervous.?
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Be the first girl to share an opinion and earn 1 extra Xper Point!
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This document is an update to the specifications contained in the Affected Documents table below. This document is a compilation of device and documentation errata, specification clarifications and changes. It is intended for hardware system manufacturers and software developers of applications, operating systems, or tools.
Information types defined in nomenclature are consolidated into the specification update and are no longer published in other documents.
This document may also contain information that was not previously published.
Quickly convert and share videos faster with Intel® Quick Sync Video.
Purchase, rent, and stream UltraViolet* movies and entertainment wirelessly to your TV.
Wind River software helps boost performance of 3rd Gen Intel® Core™ processor family.
NCR on how 3rd gen Intel® Core™ processor-based transaction retail solutions support their innovation strategy.
See what's changed with 4th gen Intel® Core™ processor performance, battery life, and visuals.
See how easily Intel® Wireless Display sends content to a TV, monitor, or set-top box.


text:
About the author:
Mickey – who has written 5723 posts on NintendoFuse.
Those are awesome!
Pingback: Graffities de Nintendo | No Soy Geek()
Woah, great!! The Miyamoto template was made by me and a friend. We painted it off a videogames shop in Barcelona (Spain). It's nice to see it here ;-P>
What did you think of Nintendo's overall presence at E3 2015?
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Les Commandos Percu spectacle of drums and fireworks at Windermere
Last updated at 14:55, Tuesday, 03 July 2012
THE stunning scenery of the Lake District provided the perfect backdrop for a spectacular display of drumming, dance and fireworks.
The fells around Bowness glowed a rainbow of different colours last night, as the world premiere of On the Night Shift was played out on stage on The Glebe.
The show, an incredible pyrotechnic display, was the result of a collaboration between Lakes Alive and French arts company, Les Commandos Percu – featuring performers from France as well as dancers hand-picked from across the UK. It was introduced on stage by world recording-holding triple jumper, Jonathan Edwards CBE.
The former Olympic athlete, who regularly holidays in the Lake District, joked with the crowds about the torrential rain, which began lashing down about an hour before the show.
He said: "When I was driving in today, I saw a sign that said the Great North Swim and the Olympic Torch Relay.
"It was almost the same thing really, wasn't it?"
On a more serious note, he added: "I never thought I would see the Olympic torch in Windermere – how incredible is that?
"Tonight the eyes of the world are on Cumbria, and tonight they're going to see an amazing performance."
Amazing it was as, following a slight delay caused by the effect of endless rain on the electrical equipment, the show got under way.
With the lake dramatically lit by the glow coming from the stage, the atmosphere was incredible – the intense, rhythmic drumming set off to perfection by the skill and precision of the dancers.
In keeping with the theme of the day, fire was a major feature of the production – the light thrown from the flames bringing the performers' movements to life in the most dramatic of fashion.
The crowds ceased to remember they were completely sodden as they stood awe-struck by the spectacle, turning their faces into the rain to look to the skies as stunning fireworks brought The Glebe to life.
Observer Jan Graham, 64, of Kendal, said: "It was absolutely amazing, so much more than I expected. This is the first time I've ever seen anything like this here in Cumbria."
David McCormack, 50, of Holker Estate, said: "It was fantastic, a great event.
"It was thrilling, and it was good to be with so many people.
"The fireworks were really spectacular and the drumming was really great, it really got into you.
"We've seen quite a few firework displays and we've been to a few drumming displays, so to see the two together was really fantastic."
Reflecting on the night's atmosphere, he added: "I think the rain added to it, it just kind of brought everybody together."
"It was a great feeling to be with everybody celebrating the start of the Olympics, it felt really special.
"It felt as though the north west is part of the Olympics, it felt like we we're connected, which is fantastic."
The premiere was a real coup for Cumbria, marking the launch of the London 2012 Festival.
One of only five events on the festival calendar, it is the only one to be held in the north of England and was designed to get the Games celebrations off to an explosive start.
Julie Tate is director of Kendal Arts International, which runs Lakes Alive.
Speaking of her pride in the success of last night's event, she said: "I think it really puts the county on the map.
"The performance was an incredible fusion of talents, performed in, arguably, one of the most stunning landscapes in the world."
First published at 10:10, Friday, 22 June 2012
Published by http://www.nwemail.co.uk
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Archive for the 'Simeone demonstration days' tag
Final Simeone Museum Demo Day of 2014 gives the people what they want
The 63 candidates for the 2014 People's Choice Demo Day at the Simeone Museum. Photo courtesy Simeone Museum.
Philadelphia's Simeone Museum is known for its extensive collection of both prewar and postwar racing and sports cars, and during the museum's "Demo Days," visitors get to see selected cars in action on the facility's three-acre back lot. Demo Days typically have a theme that unites the cars to be exercised, as chosen by the museum's staff, but for the final Demo Day of the year (scheduled for Saturday, November 29), the museum is letting its visitors choose the three cars to be driven.
The list of 63 candidates covers over six decades, stretching from a 1912 National Model 40 Semi-Racing Roadster to a 1975 Alfa Romeo Tipo 33 TT 12. Choices include a 1929 Stutz Supercharged Le Mans and a 1967 Ford GT40 Mk IV, both raced at Le Mans; a 1964 Shelby Cobra Daytona Coupe, entered into the National Historic Vehicle Registry and used by Craig Breedlove to set speed and endurance records at Bonneville; a 1953 Hudson Hornet Twin H-Power sedan with a history of hillclimb victories and a nickname of "the Satan;" a 1970 Porsche 917 LH with an instantly recognizable purple and green psychedelic livery; a 1913 Mercer Raceabout, believed to be the last surviving example with a competition history; a 1963 Corvette Grand Sport roadster; a 1958 Aston Martin DBR1 once raced by Jim Clark during his "Border Reivers" racing days; and a 1956 Jaguar D-Type, with a history of competition at tracks like Sebring, Watkins Glen and Silverstone.
Voting runs through Monday, November 24 at 5:00 p.m., and the three cars chosen by popular vote will be announced on Tuesday, November 25. The final Simeone Museum Demo Day of 2014 will take place on Saturday, November 29, with activities beginning at noon, and if history is any indication, expect the "People's Choice Demo Day" to be among the museum's most popular events.
For additional information, or to vote on the cars to be driven, visit SimeoneMuseum.org.
UPDATE (1.December): The four cars chosen for the final Demo Day of the year were the 1964 Shelby Cobra Daytona Coupe, the 1966 Ford GT40 Mk II, the 1970 Porsche 917 LH, and the 1956 Jaguar D-Type.
Ferraris to stretch their legs for Simeone Museum's Demonstration Days
The Simeone's Ferrari 250 Testa Rossa. Photos courtesy Simeone Foundation Automotive Museum.
Most automobile museums rely on static displays to paint a picture of a particular car's role in history. The Simeone Foundation Automotive Museum, located in Philadelphia, Pennsylvania, is no different, but it also uses "Driving Demonstration Days" to provide a bit of living history. On Saturday, April 12, the Simeone's demo days will pay tribute to legendary Italian automaker Ferrari, and guests will have the opportunity to see and hear six racing Ferraris run on the museum's back lot.
In addition to the museum's 1954 Ferrari 375MM and 1958 250 Testa Rossa, attendees will also get to experience a 1962 Ferrari 250 GTO, on loan to the museum, along with owner-supplied examples of a Ferrari Monza, 250 LM, and 365 GTB/4 Competition. The program begins at noon with a presentation on Enzo Ferrari, his automobiles and the importance of racing to the brand; weather permitting, live demonstrations will follow.
Ferrari demonstration, 2013.
The Ferrari Demo Day also kicks off the museum's 2014 Best of Italy exhibit, which runs from April 12 through April 27 and honors the 100th anniversary of Maserati. Fans of Italian automobiles won't be disappointed, as the exhibit is set to include an Alfa Romeo 8C; an Alfa Romeo Giulietta Sprint; an Alfa Romeo 1900SS Zagato; a De Tomaso Pantera; a Dino 246GT; a Fiat Bianchina; a Fiat X 1/9; a Fiat 500; a Lancia Pininfarina Coupe; a Lamborghini 400GT; a Lamborghini Aventador; a Lamborghini Jarama GTS; a Lamborghini Countach 5000 Quattrovalvole; a Maserati Grand Prix; a Maserati 4200 Spider; and a Maserati Ghibli Spyder.
Other upcoming Demonstration Days events at the Simeone Museum include What was the Mille Miglia, scheduled for April 26; 80 Years of Jaguar, scheduled for May 24; Pantheons of Style, scheduled for June 14; Auto Racing: A Privileged Man's Sport, scheduled for June 28; duPont: Delaware Valley's Most Prestigious Maker of Luxury Cars, scheduled for July 12; World Champions, scheduled for July 26; Racing in Style, scheduled for August 9; Stingray: Why is it Our Favorite Corvette?, scheduled for August 23; The Driving Force, scheduled for September 27; When NASCAR was for Real Stock Cars, scheduled for October 11; How did Brooklands Save So Many Cars?, scheduled for October 25; Corvette Racing Legends with Doug Fehan, scheduled for November 1; and People's Choice, scheduled for November 29.
For additional information on events at the Simone Foundation Automotive Museum, visit SimeoneMuseum.org.


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Genetic Counseling Center - Lowell, MA
Lowell Geneticist, Ph.D. Doctors for Genetic Counseling
Type of Physician: Geneticist, Ph.D.
What is a Geneticist, Ph.D.?
A certification by the Board of Medical Genetics; practitioners work in association with a medical specialist, are affiliated with a clinical genetics program, or serve as a consultant to medical and dental specialists.
Specialty: Genetics: Medical (Ph.D.)
Common Name:
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Genetics professionals are health care professionals with specialized degrees and experience in medical genetics and counseling. Genetics professionals include geneticists, genetic ...
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text:
Thank you so much for stopping by! The big news is this: you're on the new website! (You've probably figured that one out by now.) AND!!! The new EP is nearly ready!! (In fact, it's so close that you can now pre-order the project on the "Store" page.) Though it's official release is in June, you can get it signed and on your doorstep before that.
I hope you'll take a few minutes to hop around the site - if you really want to keep updated, sign up for my mailing list at the bottom of the page or get connected with me on Facebook, Twitter or Instagram!
Also, I answer all of my own emails, so feel free to message me from the "Contact" page and I'll get back to you.
See you soon!
Newest Video! New Song!
Bethel's Monthly(ish) Newsletter Signup!
I'd really love to keep you up to date with all of the happenings here in music land! Please take a minute and sign up to receive my monthly newsletter. As a thank you, you'll be directed to a free download of a couple of tunes from previous records!


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- Music
- 345 N Loomis Ave, Chicago, IL, 60624
World Flavors: Fresh + Simple Globally Inspired Recipes
Amanda Skrip
Tuesday, March 26, 2013 from 6:30 PM to 8:30 PM (CDT)
Go Global! Explore new spices and tastes from around the world - and learn to add fresh flavors to your home cooking with ease. Natural foods chef, Amanda Skrip, will create simple, healthy dishes that draw inspiration from Indian, Thai, and Mexican cuisine.
Class will be gluten free and vegetarian friendly. Some organic poultry and dairy will be used. Please let Amanda know if you have any dietary resrictions or preferences prior to class.
Part of the proceeds from this class will benefit the Whole Planet Foundation.
Ticket price includes snacks during class, food demonstration/tasting, recipe packet. There will also be fun product giveaways provided by Whole Foods Market!
*Class is located at the Halsted Whole Foods location on the 2nd Floor in the Lifestyle Center.
Sweet Potato Lettuce Wraps with Tangy Peanut Sauce
Thai Noodles Vegetable Noodles
Indian-Style Chicken with Spinach / Brown Rice
Creamy Black Beans / Roasted Carrots with Coriander
Amanda is a natural foods educator, chef, health coach, and wellness expert. Amanda received her culinary training at the Natural Gourmet Institute and continued her nutrition education at the Institute for Integrative Nutrition. After working in kitchens in New York City, Amanda relocated to Chicago and began to share her passion for natural foods and healthy lifestyle with her private cooking and coaching clients.
She believes that a healthy lifestyle is about balance, and encourages her clients to consume plant-based foods and seasonally vibrant produce. Amanda works with clients to create small shifts that have a big impact on health, weight and energy.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Media have less than three weeks to register for Europe's largest cancer congress: The 2011 European Multidisciplinary Cancer Congress in Stockholm, 23-27 September 2011. To register, go to: www.ecco-org.eu
The 2011 European Multidisciplinary Cancer Congress will take place at the Stockholmsmssan (Stockholm International Fairs), Stockholm, Sweden, (www.stofair.se) from Friday 23 September to Tuesday 27 September 2011.
There will be over 2,000 presentations and around 16,000 participants from 120 countries, making it the largest European cancer congress to date. It is the only cancer congress in Europe to offer presentations of cutting-edge research across the whole cancer field, and will include basic and translational research, first reports from high quality phase II and III clinical trials, epidemiology and much more. In addition, for the first time there will be five new tracks, including industry and "oncotechnology". The "oncopolicy" track launched at the 2009 congress will continue to tackle issues of prime importance to the European cancer community, as well as helping to inform European policy and ensuring cancer's place at the top of the EU health and research policy agenda.
There will be media news briefings at the following times:
Friday 23 September: 13.00 hrs CEST Swedish language news briefing for local journalists
Friday 23 September: 17.00 hrs CEST Opening press conference
Saturday 24 September: 08.00 hrs CEST
Sunday 25 September: 08.00 hrs CEST
Monday 26 September: 08.00 hrs CEST
Monday 26 September: 11.15 hrs CEST
With the exception of the first press conference in Swedish for the local journalists, all other press conferences will be in English.
Here is a sample of some of the news to be announced at the congress (all information is embargoed):
|Contact: Emma Mason
ECCO-the European CanCer Organisation


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Most men could probably pull off an imitation of a girl's voice if they really tried. But this guy seems to have it down to a science.
His name is Matt Bittner, and he is an New York-based actor, musician, and sound designer. After the video raked in more than 2 million views after it was posted July 9, he shot a second one with more of the now-infamous imitation. It too has gone viral!
Bittner seems pretty awed by the whole viral thing on his Twitter account.
These have been the weirdest two days ever. Thanks for the love, everybody.
— Matt Bittner (@matt_bittner) July 12, 2014
May as well pursue that voice-acting career hardcore, Matt, because that voice should be used for more than to just amaze your friends.


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Coming Events
- Jun 30, 2015
Creative Storage Conference
- Jul 30, 2015
Cloud Computing Boot Camp
- Sep 22, 2015
The Internet of Things (IoT) Show
- Oct 6, 2015
New York Media Festival (NYME)
Past Events
- Jun 30, 2015
Creative Storage Conference
- Jun 24, 2015
Cloud World Forum
DCIA co-sponsored this marquee event with Informa Telecoms & Media. Co-located with the seventh annual major international conference was Enterprise Apps World.
- Jun 3, 2015
DataCloud Europe
DCIA co-sponsored this industry event with BroadGroup. Co-located with the eighth annual Congress & Exhibition were the prestigious DataCloud 2015 Awards.
- Apr 16, 2015
Internet of Things Conference
DCIA endorsed this 2015 extension of RFID Journal Live and the RFID IEEE Committee Meeting. The Internet of Things (IoT) Conference attracted business professionals interested in learning how to benefit from IoT today.
- Apr 11, 2015
NAB Show
The DCIA supported fourteen Member companies that exhibited at this major event, with video webcasts, marketing communications, business meetings, media relations, and invitational special activity participation.
- Apr 8, 2015
DataCloud South East Asia
DCIA co-sponsored this event with BroadGroup. Included were a special Finance & Investment Symposium, tours of the Iskandar section of Johor, and meetings with government agency officials.
- Jan 6, 2015
DCIA's IoT Marathon at CES 2015
Four days of HD-video recording sessions took place from January 6th through 9th in Las Vegas, NV, covering this newest and arguably largest-ever industry phenomenon. Twelve hours of demos, displays, and discussions were captured for this major industry webcast in the Distributed Computing Industry Association's (DCIA) production studio at the Sands Expo & Convention Center; and on location in meeting rooms, hospitality suites, and exhibit booths throughout CES.
- Oct 1, 2014
This CCA-DCIA co-sponsored event featured co-located instructional workshops and conference sessions on six tracks facilitated by industry-leading speakers and world-class technical trainers.
- May 15, 2014
In this CCA-DCIA co-sponsored event, three major conference tracks zeroed in on the latest advances in the application of cloud-based solutions for these key economic sectors: government, healthcare, and financial services.
- Jan 8, 2014
CONNECTING TO THE CLOUD at CES 2014
This DCIA Conference within CES highlighted cloud-based solutions revolutionizing the consumer electronics (CE) sector, with special attention to the impact on consumers, telecom industries, the media, and CE manufacturers.
- Dec 31, 2013
Events from 2013 and prior
This page lists all events from 2013 and prior.


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Reaction to Secretary Rumsfeld's Testimony Before Congress
[Sorry, the video for this story has expired, but you can still read the transcript below. ]
- Online NewsHour Special Report: The New Iraq
- May 7, 2004: Update: Rumsfeld Offers 'Deepest Apology' for Iraqi Prisoner Abuse
- May 6, 2004: Experts discuss recent criticism of Defense Secretary Rumsfeld over the Iraqi prisoner abuse scandal
- May 5, 2004: Arab world reacts to Iraqi prisoner abuse, President Bush's comments.
- May 5, 2004: Text of President Bush's interview with Al-Arabiya
- Text of President Bush's interview with Al-Hurra
- May 5, 2004: Update: President Bush Denounces Iraqi Prisoner Abuse on Arabic TV
- May 4, 2004: Two Senators discuss the impact of the scandal and investigations into U.S. military prison practices.
JIM LEHRER: Now, reactions from the leaders of the Senate Armed Services Committee, and to Margaret Warner.
MARGARET WARNER: And we get that from the committee's Republican chairman, John Warner, and the ranking Democratic member, Carl Levin.
Welcome, senators.
Senator Warner, what new did you learn today from Secretary Rumsfeld about how and why this abuse occurred?
SEN. JOHN WARNER: Well, a great deal in this perspective. My good friend, the ranking member Carl Levin, and I have been on this committee 25 years. We've been through a lot of hearings. And today was an extraordinary one, for any number of reasons, given the tragic nature of these facts, the implications on our foreign policy, the implication on our forces, our forces which are bravely fighting on all over the world in the cause of freedom.
But what we did learn is, I thought, very candid answers in response to very tough and thorough, but fair, questions. We gained a lot of information. And I think the secretary carefully said what he knew to be fact and what he expected to learn. For example, "regrettably, but I think understandably, much more evidence is to come out." And the secretary very carefully advised the committee of that. The nature of that evidence we know not, except that it's likely to be various ramifications of what we've already seen.
But it does provide, unfortunately, the media of the world an opportunity each day to grind a new chapter. And I'm just hopeful that our men and women of the armed forces understand that we are pursuing this revelation of facts according to the deeply rooted democratic principle of this country of freedom of information, freedom of speech, sharing with the public, and getting it all out there so the sooner it's behind us, they can then put it behind them. I'm talking about 99.9 percent of the men and women of the armed forces who are valiantly and courageously carrying out their missions throughout the world and here at home.
MARGARET WARNER: Senator Levin, just to sharpen that… my question a little bit, what did you learn, or what have you concluded now after reading the investigative report and hearing Secretary Rumsfeld, about whether this was one MP unit run amuck, or whether there were either policies, orders that encourage or condoned this behavior?
SEN. CARL LEVIN: According to the testimony in the Taguba report, and even the photographs that reinforce that to indicate some really strong evidence that this was an organized effort to extract information from the people who were being detained, to get information from them by using MP's to mistreat them in the way that they were mistreated, to soften them up. In the words of one of the MP's in the Taguba report, this is more than MP's misbehaving and conducting themselves in the despicable ways that they conducted themselves.
This is, it seems to me, quite clear part of a pattern, an effort, to obtain and extract information for the intelligence folks. And they're the ones, if in fact this is true, that have got to be held accountable. And there was some reluctance, I felt at the end on the part of Secretary Rumsfeld, when he said that he can't imagine that anybody could have approved or encouraged that kind of behavior. Well, it's kind of hard to imagine the behavior itself. But once you see the behavior itself, frankly, it not hard to imagine that somebody put them up to it.
MARGARET WARNER: Senator Warner, let me just follow up on that. Secretary Rumsfeld did say that he thought there was an effort, and he thought it was appropriate to somehow link the way these mostly men were being held with efforts to make the interrogation more "effective," was his word. Do you think that could have been a factor, I mean, based on what you have learned this week?
SEN. JOHN WARNER: Well, clearly, these men were held for reasons. They had reason to believe that their participation, either on the field of battle or elsewhere, was against the goals of the coalition forces to bring freedom to Iraq. But I want to commend the president of the United States, President Bush. He was the first to step in and apologize. And each one of our witnesses today offered the same apology and total condemnation of the breakdown of discipline, the non-professional behavior, and the obtaining– if they did obtain, we are not sure of that– obtaining of information and in fact by means of cruelty that just is not a part of our military history.
MARGARET WARNER: But do you think it was in response to some kind of encouragement, some kind of policy that was higher up than this one MP unit?
SEN. JOHN WARNER: Well, there we don't have solid facts. I've always been of the opinion that our young men and women, when they leave the towns and villages of this nation, going through the arduous training to become soldiers, sailors or airmen, marines, they're the finest that we have. And they want to go abroad in the cause of freedom and fight, if necessary, or do their duties and respond to the orders of their superiors, whether that superior be a sergeant or a lieutenant or up the line. And I can't imagine that all these individuals, collectively put together, got into this unit and suddenly began to do things which are contrary to what they were taught at home as young people and taught in their schools. If not, someone hadn't instructed them to, in some way, deviate.
MARGARET WARNER: And who do you think that someone was, Sen. Levin?
SEN. JOHN WARNER: I'm not going to speculate.
MARGARET WARNER: Senator Levin, based on what you have.
SEN. CARL LEVIN: I believe there's significance evidence that the military intelligence people and the contractors that were hired here privately were using these MPs, encouraging them to obtain infor… to soften up… soften up the people who were being held, the prisoners, so that then when the interrogators came along, they would provide intelligence.
Is that known yet beyond a reasonable doubt? No. But there is testimony right in general Taguba's report from the MPs that that is what the intelligence folks told them that they wanted. They wanted them to soften up those inmates and those prisoners. And there's significance evidence, even looking at the pictures, as a matter of fact, that there was some kind of a methodology here. This is not just a few people acting in their own aberrant ways. These are people in a room– six, seven people, you can see in a picture– some people helping other people, other folks just standing by in a corner. It would be easier to believe, somehow or other, that this was just a few people engaging in incredibly sadistic and unbelievable behavior.
But I'm afraid that there's too much evidence, even in the report of the army, to the contrary, that these folks were in fact working with the intelligence people, or at least thinking they were getting signals from the intelligence people, that they should soften up these prisoners.
MARGARET WARNER: And Sen. Levin, the other focus of the hearing, of course, is how the Pentagon has handled this ever since reports of abuse came to them. What's your assessment there?
SEN. CARL LEVIN: Well, they were very late in sharing this information, obviously, with the Congress. I want to give Sen. Warner credit. He has taken the lead in really forcing into the open this information: Getting this hearing today, put together on very short notice, to really get the Pentagon to come forward and to share with us what they knew and when they learned it.
So they had an opportunity last week to share this with us when they met with about 40 senators. They did not do so even though it was the same day that there was going to be a television program showing these abuses. And they should have done it at that time. They have not been forthcoming, as far as I'm concerned. But our chairman, Sen. Warner, is surely doing everything he can to get this information out to the public so that we can then hopefully get beyond it.
MARGARET WARNER: Sen. Warner, let me ask about the question of whether Secretary Rumsfeld should resign. Do you think his apology today was enough, or do you think he should resign?
SEN. JOHN WARNER: I want to be very careful about this. And first I would acknowledge that, yes, I'm chairman. I was preceded by Carl, who was chairman, and we have worked together these 25 years. And I think through our joint leadership, our members of our committee brought in before the public view today a good Senate hearing that was thoroughly given the opportunity to learn.
Now, as to Rumsfeld's situation, I've known him for many years. We started way back together as youngsters in the Nixon administration. I was secretary of the navy, and I served under three consecutive secretaries of defense for five years during the War in Vietnam. And since that time, working with Carl, we've served these 25 years in the Senate Armed Services Committee. We've known a lot of them. I would rate Rumsfeld as a very competent secretary of defense. We work together cooperatively, we had our differences, but nevertheless, we both made an effort to work — and a strong bond between the Congress and executive branch as it relates to the Department of Defense.
The question was raised, and I think the president gave the answer; he said, "I want him to stay in the cabinet." And I support the president in that view, and I feel that Secretary Rumsfeld and I can continue to work just as we did before this tragic incident.
MARGARET WARNER: Sen. Levin, I would like to ask you the same question, and particularly ask it from the point of view that Sen. Bayh brought up today, which is, he said to Secretary Rumsfeld, "Even though you weren't directly involved, do you think perhaps you need to resign to demonstrate to the world how seriously the American government takes this?"
SEN. CARL LEVIN: And I think Secretary Rumsfeld's answer was that it is possible, as I remember. And he's right, it is possible; that it would help to restore confidence. If I thought his resignation would result in the changes that are necessary in underlying policies, I would very much favor that. But I don't think the underlying policies… and there has been too much… too many errors, too much mismanagement of this war, I don't see that changing with a change in the leadership in the Defense Department. And in terms of these events particularly, I think that Secretary Rumsfeld's answer is the right one. It is possible, particularly if there is more and more information unfolding, that a resignation would help to restore some public confidence. But from my perspective, it's the underlying policies which are the issue at this point.
MARGARET WARNER: Senators Levin and Warner, thank you both.


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Official "I just got a Geforce GTX 5xx thread"
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Ducking & Dodging
Join Date: Mar 2008
Posts: 3,948
Re: Official "I just got a Geforce GTX 470/480" thread
Originally Posted by
Yeah, it does run a little better in DX10, but its still not a whole lot different than my 260. At least the load times are better than in DX11 though. I wonder if they'll ever fix that bug.
Meh... I'm still on the fence.
I think if I was totally happy with at least one aspect of this card I'd keep it for sure, but after selling my 260 I'll probably have around $180-$200 into this GTX 470. If I'm not happy with it, that's a waste of money.
EDIT: LOL, I just remembered that I took the side off of my case while playing this game. So the 81C load temp I reported earlier was with an open case...
well to be completely honest with you BF BC2 is the worst gaming experience I've had with the GTX 480. Have you tried any other games? GTA IV EFLC gets alot more frames than my HD5870 got. Also, Metro 2033 runs much better. BF BC2 has problems, from what I've read, the last patch has really bombed Nvidia cards FPS. I guess what I'm saying is that I wouldn't base my decision completely on BF BC2.
i7-2600k @ 4.6Ghz, Zotac GTX 680 (1310/7000), 16GB DDR3 1600, 2 x 1TB Samsung F3 RAID 0, Windows 7 x64, CPU and GPU custom watercooled
Originally Posted by
General Lee
Oh, if the whole world had only one neck for me to squeeze in my hands...
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Press ReleasesViewing by tag: police
New Zealand still the world's top consumer of cannabis
posted on the March 22nd, 2013 by Chris
New Zealand and Australia have the highest rates of using cannabis in the world, according to the United Nation's 2012 World Drug Report. In 2010 (the most recent year for which international data was available), marijuana consumption was most prevalent in Australia and New Zealand, with the United States and Canada tied for second, followed […]
NORML call on 2500 to take Court action
posted on the July 18th, 2012 by norml
NORML New Zealand is calling on all 2500 people charged for cannabis in Operation National to enter Not Guilty or No Plea at every court appearance to clog the court system. NORML vice-president Abe Gray said that if the 2500 people refused to plead guilty, cannabis prohibition would become unworkable immediately. "By pleading Not Guilty […]
Problems with cannabis potency claims
posted on the January 18th, 2012 by Chris
New Zealand Police are complaining that domestic cannabis has apparently "quadrupled in strength". Aside from the obvious point that if cannabis is stronger consumers don't need to smoke as much, there are several problems with this claim. We thought the NZ Drug Foundation covered it well: http://www.drugfoundation.org.nz/mythbusters/cannabis-potency Cannabis potency Thursday, November 25, 2010 "New Zealand […]
Drug driving campaign may backfire
posted on the January 13th, 2012 by norml
NORML supports efforts to reduce impairment on the roads, and our own "Principles of Responsible Cannabis Use" invoke a no-driving clause. However, like with alcohol it is important to distinguish between use and impairment. Furthermore, efforts to reduce the use of drugs may actually backfire by encouraging more use of alcohol, a far more dangerous […]
New Police Policy of 'Two Strikes' Will Hit Maori Hard
posted on the December 13th, 2010 by norml
NORML NZ says a new police programme whereby first-time offenders caught committing minor crimes are being let off with a warning will hit young male Maori hard, calling it a policy of 'two strikes and you're out'. "We already know that Maori in general, but young male Maori in particular, are more likely to be […]


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Latest Book Uploads V2
Your fav Rock/Metal Band !!!
What movie did you last watch? And what did you think of it? V.3!
Torrents That Need a Category Change - Post Here For Super Users & Translators To Move V2
FrootVPN, Who has paid and still have not had their accounts activated? Does anyone have an active paid account?
Mr. Robot Discussion Thread
KickassTorrents is moving to kat.cr domain
Happy Torrents Day 2015!
Technical maintenance (March, 17)
SushiKushi Website & Social Media Update!
The material world is a lie
What's in a Name?
Summer Music 2015
Microphone Mafia Mixtape Released
New Movie releases and Blu-ray releases Week 28 (July 6 - July 12)
spanish big bang theory
The Theory of Everything 2014
conception 2013
侵乳 16 舞岡結希
Love Giovanni
fast.food.nation.limited.dvdrip.xvid lmg
antivirus android


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Oracle's .NET development community numbers over 800,000 members. With Oracle's extensive support, Visual Studio developers can take full advantage of database and application server technologies, such as performance self-tuning, Real Application Clusters, messaging, and simplified management of advanced data types, such as XML, SecureFiles, and user-defined types. All this at no cost! At the OTN .NET Developer Center, both beginner and advanced .NET programmers can enhance their Oracle skills through step-by-step tutorials, technical articles, white papers, and videos.
Subscribe to the Oracle .NET newsletter for the latest events and news.Follow @OracleDOTNET
See also: Windows Server System Center
What's New
OTN Virtual Technology Summit
Attend the OTN Virtual Technology Summit, featuring a database track devoted to just .NET development. Learn first hand from Oracle .NET product experts, as they share their insight and expertise. This event is free for all to attend! It is being held at convenient times for a worldwide audience.
Updated ODP.NET NuGet Releases
ODP.NET, Managed Driver and ODP.NET, Maanaged Driver for Entity Framework have been updated with MSLSA support and simpler TLS/SSL port setup, plus bug fixes. Downloads are available from nuget.org
Production Release: ODAC 12c Release 3
ODAC 12c Release 3 includes support for Entity Framework 6 Code First and Code First Migrations; NuGet, .NET Framework 4.5.2; and ODP.NET, Managed Driver XML DB.
Oracle By Example Walkthroughs for Visual Studio 2013
The .NET Oracle By Example (OBE) lessons are now available for Visual Studio 2013. Learn how to develop .NET applications with Oracle Database with these step by step lessons. Check back often as we will be adding updated lessons in the weeks to come!
Customers Using Oracle Database and .NET
Learn how customers are making their applications more powerful, faster, and faster to market with the power Oracle Database brings to .NET development.
Oracle .NET Recorded Presentations and Webinars
You can watch replays of past webinars or YouTube videos on developing .NET apps for Oracle Database. The ODTUG webinars require the GoToMeeting codec, G2M3, to play the video, which can be downloaded here.
.NET Support for Oracle DatabaseData Sheet: ODAC 12c Release 3 (126.96.36.199.1) (PDF)
Data Sheet: ODAC 12c Release 2 (188.8.131.52.2) (PDF)
Data Sheet: ODAC 12c Release 1 (18.104.22.168.0) (PDF)
Video: Oracle integration with Visual Studio 2010 demonstration
Data Sheet: ODAC 11.2 Release 4 (188.8.131.52.0) (PDF)
Data Sheet: ODAC 11.2 Release 3 (126.96.36.199.1) (PDF)
Data Sheet: ODAC 11.2 Release 2 (22.214.171.124.2) (PDF)
Technical White Paper: Oracle Database 11g Release 2 Application Development (PDF)
Data Sheet: ODAC 18.104.22.168.20 (PDF)
Technical White Paper: ODP.NET 188.8.131.52.20 (PDF)
Data Sheet: Oracle 11g (22.214.171.124) on .NET (PDF)
Technical White Paper: ODP.NET 11g (PDF)
Technical White Paper: New 11g Features in Oracle Developer Tools for Visual Studio (PDF)
Technical White Paper: Oracle Database 11g on Windows: Development and Deployment (PDF)


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When a peacock unfurls it's feathers the display is simply gorgeous. Put a feather in your cap when you add this amazing pair if peacock eyelashes to your costume - it will stop them in their tracks.
You'll be pretty as a peacock when you create your costume with this Peacock kit - it includes a delightful tutu skirt and a headpiece so you can strut your stuff with style.
You'll look ravishing whether you plan to wear this Peacock Deluxe Mask for a masquerade party, Halloween, or both! Bronze mask is decorated intricately with blue and gold patterns and and topped off with a few elegant peacock feathers.
Your baby will be spreading their wings in the Peacock Infant Costume. Be the most colorful animal on the block in this plush blue jumpsuit with green and orange feathered back detail and peacock headpiece.
Fluff those feathers this Halloween in the Peacock Bra Women's Costume. Show off your colorful persona in this black and blue bra top with beautiful blue and peacock feathered bodice.
Flock above the rest in the Pretty Peacock Girls Costume. Prance around as a vibrantly, stunning peacock in this jewel toned purple and blue dress with sheer tail, elaborate collar and feathered headpiece.
Spread those elegant wings and fly door to door on Halloween wearing this Peacock Girls Childs Costume! Colorful dress and wings display vibrant colors of indigo, aquamarine, and emerald, with hints of gold embroidery at the front and the hem of the dress. Feathery headpiece also included to top off…
Top off our fancy flapper costume with the White Peacock Flapper Headband. This white, stretch headband pairs perfectly with any sparkly flapper costume that you could imagine.
Prance, preen and be pretty when you create your costume with this Peacock costume kit. Your plumage includes a peacock headpiece and tail; you add the fabulous outfit and accessories.
You'll be proud as a peacock when you strut your little one out and about on Halloween in this spectacular Baby Peacock infant costume - it is amazing. The elaborate plumage is attached to the body of the costume and the matching hood adds the finishing touch. Perfect!
Prance, preen and proudly strut your stuff in this fantastical Blue Peacock tween costume - blue, teal and green with gold trim - it's simply stunning. All eyes will be on you in this whimsical costume and you won't even have to flaunt your feathers.
Prance and preen through the party in this lavish Peacock adult womens costume. You're destined to be the center of attention when you slip on this green and black, 100% polyester dress, complete with feather accents, matching neckpiece, tailpiece and headpiece.
Display your little one in this Precious Peacock baby costume for a perfectly wonderful Halloween. The glorious plumage attracts all sorts of attention and the vibrant costume will pop in pictures. The blue, yellow and green lined zippered jumpsuit has a detachable tail and leg snaps for easy diaper…
Display some amazing plumage when you dress your for-legged friend in this officially licensed Animal Planet dog costume on Halloween. It's just the thing to make a dog walk more like a walk down the runaway so strut your stuff!
Flaunt your goodies like an elegant bird flaunts his feathers when you wear this Midnight Peacock Adult Womens Costume. Lace-up corset style dress ruffles at the bottom and includes garters that you can attach to a pair of sexy thigh-highs, not included. Feather face mask comes with set so you'll…
Strut your stuff when you create or complete your costume with these stunning adult women's Peacock Feather pumps - the micro fiber pumps include two peacock feather shoe clips!
Add some creeptastic flavor to your costume when you add the Twisted Wig. This dark, polyester, bob-length wig is perfect for Goth-ing up any costume of your liking.
Rock out in the Rockabilly Wig, and have everyone follow you onto the dance floor. This retro style auburn wig features a red rose and bandana headband.
Get your Einstein look together when you wear the E=mc2 Wig. This incredible white, synthetic wig comes complete with a matching mustache, so you can solve all types of equations on Halloween.
Some of us have a lazy day every now and then, but you'll look like you've had a lazy life when you wear the Slacker Wig. This unkempt, brown wavy wig is comprised of synthetic fibers and would be perfect for any kind of grunge funny costume.
Tumble through the rabbit hole when you decide to top off your Alice in Wonderland costume with the Alice Wig. This straight, golden blonde wig features an attached black bow detail, so you can really get into character.
Felling blue? You'll feel all-new when you don this stunning black and blue Chromatic wig and create a whole new you. Release your inner star and shine on Halloween in this fabulous wig; use it to create or complete your costume.
Lead the gang and rule the school when you create or complete your costume with this jet-black bad boy adult men's Greaser wig
Give those groovy babes and seafarin' wenches something to grab onto with this hilarious chest wig! Thick, brown, and oh so touchable, this funny wig shows off you manliness whether you're a funky disco dude or a fearsome pirate.


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|Find the Fair Market Value of a Business The Fair Market Value of a Business may be estimated by inputting data from current Profit and Loss Statements and the Balances Sheet to the Excel spreadsheet program below. Instructions for using this tool are on the spreadsheet..
|Valuing A Small Business For Sale Pricing a business correctly is important if you really want to sell it. As a consultant I talk to many business owners, brokers, and agents on a daily basis about valuing businesses. It always amazes me on how some of these individuals come up with the values on small businesses being sold. No...
|Dissolving a Business Dissolution is the process of voluntarily ending your business. Deciding to end a business can be a stressful and overwhelming process, but it's important to complete the necessary steps to dissolve the formal business entity as it lets the state (or states) know your business is no...
|Covering Your Back: The Buy-Sell Agreement During a business start-up's early stages, it's really the last thing on your mind that something could happen to one of the partners (or even yourself). But if that came to be, it could put a share of the business up for grabs and everyone's dreams at risk. Investing a little...
|Preparing Your Business for Sale If you are seriously considering exiting your business by selling to a third party, there are several steps you should take before you begin actively marketing your company. The more time you allow for advance preparation, the better, though most of the following steps can be taken during the few...
|Seller Financing Steve Strauss, founder of www.theselfemployed.com, explains the concept of seller financing and how/when it may work for buying a business.
|Best Practice for Selling Your Business USA Today columnist, Steve Strauss, gives advice on the best ways to sell your business in a struggling economy.