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Accelerating and Automated Rapid Microbial Testing
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Christof Hasse / Anna Mills / David Jones
Rapid microbial testing methods in quality control continue to gain acceptance in pharmaceutical manufacturing, but most companies continue to use manual, traditional methods. The ability to uncover results in less time than traditional methods provides compelling benefits to manufacturers. These benefits can be realized in environmental monitoring, sterility testing, water and bioburden testing.
Learn from experts where rapid technologies, like the Growth Direct™ System can have an impact on microbial quality control and ultimately manufacturing.
Attendees will learn:
- The limitations of the traditional methods
- The importance of non-destructive testing
- The benefits of automated, rapid detection
Nov 14 2012
64 mins
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Single-Use Chromatography – a Feasible Unit Operation?
Dr. Joachim Walter & Dr. Günter Jagschies
Jul 2 2015
68 mins
Though single-use technology and the general use of disposables are widely accepted and applied both in process development, pilot plant and selected production processes, they are not in general a reasonable choice at any scale or application. Notably process chromatography is considered a critical unit operation regarding feasibility to single-use application with the chromatographic matrix assumed to be the typical cost driver. But is this really true? The answer to this quite ambivalent: it depends! Numerous young and innovative companies have developed new and/or alternative products which can help to significantly reduce the costs of goods, thus providing an interesting basis for single-use applications. After all, taking into account reasonable scales and suitable manufacturing targets, the doors have been opened widely due to the supply of appropriate low-cost matrices and feasible hardware.
Read more >
Effectively using real-world data for commercial success
Christian Marcazzo, Robin Munro, Paul Tunnah
Jul 1 2015
67 mins
Life sciences companies need to make better use of the insights that real world data (RWD) can provide in order to improve market access, sales and market growth strategies – and ultimately to improve the applicability of new and existing therapeutics for patients. Insights come not just from the multiple sources of RWD available, but from advanced analytics that highlight the effectiveness of a treatment by geographic area, and link healthcare providers, institutions and patients to relevant and meaningful outcomes.
This one-hour event will take a hands-on approach – detailing how insights derived from RWD (and collaboratively with other sources) are enabling all elements of the life science industry to do things better.
Insights experts Robin Munro and Christian Marcazzo will deliver case studies on how RWD can help life science companies in:
Sales and Marketing – incorporate RWD and evidence into segmentation, targeting, and engagement of physicians and institutions
Commercial Effectiveness – measure commercial campaigns, and demonstrate the impact to the healthcare system
Medical Affairs – find and engage medical education prospects and target appropriate healthcare authorities, healthcare professionals and payers, to improve quality of care and outcomes
Public Affairs and Market Access – develop qualitative and quantitative insights to design education, advocacy and access-related campaigns within the healthcare ecosystem
The event will also give an exclusive look at what can be achieved from combining data sources – using Diabetes in England as a case study, Zephyr has implemented novel methods to demonstrate an evidence-based approach to improving information sharing within sales teams and to engaging accounts and payers. We explore how patient outcomes from RWD can add value to commercial strategy.
Read more >
Biased ligands in Drug Discovery: the case of TRV027
Nicolas Pierre (Cisbio Bioassays) & William Gowen-MacDonald (Trevena)
Jun 30 2015
27 mins
Special Guest Terry Kenakin Ph.D. will be taking part in our LIVE Q&A session answering your questions!
Ligand bias is a well-established concept in the GPCR research field that is beginning to emerge as a means to optimize GPCR targeted drug design. Most approved medications that target GPCRs act as either agonists or antagonists of heterotrimeric G protein and β-arrestin pathways. In many cases, this classical signaling paradigm leads to both efficacy and on-target adverse events. Biased GPCR ligands have the ability to activate or inhibit with greater selectivity one of the two downstream effector proteins and its subsequent signaling cascades. The goal of this webinar is to illustrate in vitro characterization of GPCR ligand bias and its translation to in vivo proof-of concept using TRV027, an AT1R modulator, as an exemplar biased ligand.
> What attendees will learn about?
• Review of GPCR signaling
• Introduction to concept of ligand bias and quantification thereof
• Utility of 2nd messenger assays in GPCR drug discovery
• Pre-clinical biased ligand proof-of-concept
Read more >
Pharmaceuticals Market Briefing
Rathanesh Ramasundram
Jun 26 2015
62 mins
The Asia Pacific is the third largest pharmaceutical market in the world after North America and Europe, with generics being the major driver for the pharmaceutical industry in this region, aided by factors such as the aging population and impending expiry of patented drugs. It is a necessity for pharmaceutical companies to be aware of the key trends in the APAC generics market and maximise the market opportunities in order to remain relevant.
In today's rapidly evolving business landscape, pharmaceutical companies are also starting to realise the importance of the customer experience as a key differentiator. With a gradual shift from product to the customer, the pharmaceutical industry needs to keep up with other industries in terms of providing the perfect digital customer experience. A well-executed digital strategy is essential for today's pharmaceutical companies to better connect with their clients.
Join us as we discuss these and other key topics.
Read more >
How to Choose the Right Cell Line for Your Research NA
Valerie Speirs, Professor of Experimental Pathology and Oncology, University of Leeds
Jun 25 2015
54 mins
Cell lines remain the workhorses of laboratory research, both in academic and industrial settings. This webinar will focus on best practice in selecting and maintaining cell lines for research, to ensure research outputs are relevant and reproducible. Features of cell lines that might be used in selection will be discussed. This will include monolayer or suspension culture; passage number; doubling time; immortalisation; karyotype; receptors; expression profiling and use of bioinformatics tools like the cancer cell line encyclopaedia. Using breast cancer as an exemplar, I will discuss more specifically how to choose the most relevant cell line model to address a particular research question. Finally I will describe how to use (and access) human material to help develop more clinically relevant cell culture systems to model human disease and the role that biobanks play in this process.
Read more >
How to Choose the Right Cell Line for Your Research (EMEA)
Valerie Speirs, Professor of Experimental Pathology and Oncology, University of Leeds
Jun 25 2015
56 mins
Cell lines remain the workhorses of laboratory research, both in academic and industrial settings. This webinar will focus on best practice in selecting and maintaining cell lines for research, to ensure research outputs are relevant and reproducible. Features of cell lines that might be used in selection will be discussed. This will include monolayer or suspension culture; passage number; doubling time; immortalisation; karyotype; receptors; expression profiling and use of bioinformatics tools like the cancer cell line encyclopaedia. Using breast cancer as an exemplar, I will discuss more specifically how to choose the most relevant cell line model to address a particular research question. Finally I will describe how to use (and access) human material to help develop more clinically relevant cell culture systems to model human disease and the role that biobanks play in this process.
Read more >
Sample Preparation Considerations for Multiplexed MRM LC-MS Protein Assays.
Jeffrey Turner, Manager-Proteomics R&D,S-A & Steve Hunsucker,Ph.D. Sr Director-Lab Operations, Integrated Diagnostics Inc
Jun 23 2015
61 mins
Multiplexed protein assays have tremendous potential in clinical diagnostics, in particular measurement of proteins in plasma or serum derived from circulating blood. The dynamic range of protein concentration in these samples, and the dominance of very high abundance proteins such as albumin and immunoglobulins, make measurement of low concentration proteins impossible without some type of enrichment approach. This workshop will discuss the benefits of using Seppro® protein depletion columns in sample preparation for multiplexed LC-MS protein clinical assays.
Read more >
Vitamin E: new research on health benefits and proven safety
Prof. Jeffrey Blumberg, Ph.D Senior Scientist and Director Tufts University, Dr. Manfred Eggersdorfer DSM, Jacob Bauly DSM
Jun 23 2015
58 mins
Vitamin E is a powerful antioxidant, an essential nutrient needed to maintain cellular structures and functions, thus helping support health. However, intake still remains low among consumers globally. There is an ongoing discussion about the optimal vitamin E status in healthy populations and its role in maintaining liver and brain function outside of nutritional recommendations.
New and ongoing research suggests that vitamin E at higher doses may help maintain tissue function in specific risk groups, such as age-related macular degeneration, Alzheimer's disease and non-alcoholic fatty liver. Applications like these require the advice and supervision of health care professionals. It is important to revisit both the required doses and safety for targeted vitamin E intakes for these conditions. Further research will be required to support qualified health claims for mitigating the outcomes of these diseases.
Join the latest webinar in our series on research related to vitamin E. Hear our speakers Prof. Jeffrey Blumberg and DSM's Prof. Manfred Eggersdorfer and Jacob Bauly present their latest findings on vitamin E safety and its implications on the recommended intake across different life stages and conditions.
Read more >
Drug Delivery
Dr. Zhen Gu, Ph.D.
Jun 23 2015
59 mins
Novel applications in materials science as applied to drug delivery.
Read more >
Vitamin E: new research on health benefits and proven safety
Prof. Jeffrey Blumberg, Ph.D Senior Scientist and Director Tufts University, Dr. Manfred Eggersdorfer DSM, Jacob Bauly DSM
Jun 23 2015
58 mins
Vitamin E is a powerful antioxidant, an essential nutrient needed to maintain cellular structures and functions, thus helping support health. However, intake still remains low among consumers globally. There is an ongoing discussion about the optimal vitamin E status in healthy populations and its role in maintaining liver and brain function outside of nutritional recommendations.
New and ongoing research suggests that vitamin E at higher doses may help maintain tissue function in specific risk groups, such as age-related macular degeneration, Alzheimer's disease and non-alcoholic fatty liver. Applications like these require the advice and supervision of health care professionals. It is important to revisit both the required doses and safety for targeted vitamin E intakes for these conditions. Further research will be required to support qualified health claims for mitigating the outcomes of these diseases.
Join the latest webinar in our series on research related to vitamin E. Hear our speakers Prof. Jeffrey Blumberg and DSM's Prof. Manfred Eggersdorfer and Jacob Bauly present their latest findings on vitamin E safety and its implications on the recommended intake across different life stages and conditions.
Read more >
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Pharmaceuticals, Food & Beverage
Increasing throughput and sensitivity of LC-MS assays
Jul 28 2015
2:00 pm
75 mins
AB Sciex: Jason Causon, Senior Applications Specialist & Remco van Soest, Product Manager
Presentation 1: Jason Causon, Senior Applications Specialist, Sciex
Development of bioanalytical LC-MS methods for the detection of therapeutic peptides and the proteolytic fragments of larger proteins and antibodies is growing along with the increasing number of peptide and protein drugs entering clinical research and development. Development of these methods present challenges that are different to small molecule method development because of the multiple charge states possible for a given peptide, the abundance of product ion possibilities and the large number of proteolytic fragments possible from a protein digest. In addition to optimizing for sensitivity, on-column HPLC method development is time consuming for the same reasons. In this webinar we present an automated tuning and optimization workflow with on-column validation using DiscoveryQuantTM 3.0 software with the new ChromaTune feature to overcome some of these challenges and make the optimization of peptide MRM methods easier and less time consuming.
Presentation 2: Remco van Soest, Product Manager, Sciex
Electrospray Ionization efficiency increases at lower flow rates. In this Webinar we will discuss how microLC can help you improve sensitivity in sample limited applications in bio-analysis by LC-MS. In order to analyse the same volume of sample as is typically injected in a conventional LC-MS system, up to 50 µL, we have developed a microLC system that allows for fast on-line pre-concentration on a short trap column. Because of the higher flow rates that can be used for loading the sample on the trap-column, sample throughput is not affected by using microLC flow rates for the LC-MS analysis.
Biased ligands in Drug Discovery: the case of TRV027
Jun 30 2015
27 mins
Nicolas Pierre (Cisbio Bioassays) & William Gowen-MacDonald (Trevena)
Special Guest Terry Kenakin Ph.D. will be taking part in our LIVE Q&A session answering your questions!
Ligand bias is a well-established concept in the GPCR research field that is beginning to emerge as a means to optimize GPCR targeted drug design. Most approved medications that target GPCRs act as either agonists or antagonists of heterotrimeric G protein and β-arrestin pathways. In many cases, this classical signaling paradigm leads to both efficacy and on-target adverse events. Biased GPCR ligands have the ability to activate or inhibit with greater selectivity one of the two downstream effector proteins and its subsequent signaling cascades. The goal of this webinar is to illustrate in vitro characterization of GPCR ligand bias and its translation to in vivo proof-of concept using TRV027, an AT1R modulator, as an exemplar biased ligand.
> What attendees will learn about?
• Review of GPCR signaling
• Introduction to concept of ligand bias and quantification thereof
• Utility of 2nd messenger assays in GPCR drug discovery
• Pre-clinical biased ligand proof-of-concept
Basics of calibration and adjustment in Thermal Analysis - Useful tips and hints
Jun 5 2015
23 mins
Nicolas Fedelich, Thermal Analysis Senior Applications Specialist, Mettler Toledo
Thermal analysis instruments must always be accurate, true and precise in order to deliver reproducible results within a given range. Performing a calibration determines whether your module is delivering correctly measured values or whether it needs an adjustment. The different parameters that must be calibrated are temperature, heat flow, mass, length and modulus. In this Webinar, we will discuss the basics of calibration and adjustment in thermal analysis whilst offering some useful tips and hints.
Accelerating Pharma R&D using Mass Spectrometry and NMR
May 26 2015
54 mins
University of Dundee & Bruker Daltonics
Accelerating Pharma R&D with Novel MS Applications for High Throughput Screening (HTS), Drug Imaging and Integrating MS and NMR data for high confidence structure verification of small molecules.
This webinar will introduce novel MS and NMR solutions and its applications in pharmaceutical research:
> NMR Spectroscopy and Mass Spectrometry are two fundamental techniques for small molecule structure verification. Bruker FUSION-SV - a new software solution for comprehensive fully automated small molecule structure verification – simplifies and accelerates the drug design and discovery phases in the pharmaceutical industry significantly. The new Bruker FUSION-SV™ is a software solution integrating high resolution accurate mass (HRAM) data and complementary NMR data, into one result - increasing significantly the specificity and throughput for small organic molecule structure verification. Synthesis chemists will get a prompt result without being an expert spectroscopist.
> Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) instruments are ideally suited for high throughput screening (HTS) in drug discovery. Not only speed, simplicity and robustness are the convincing arguments for MALDI-TOF MS but the inherent strength of a label- and solvent-free technique. The webinar will explain the technique and advantages of MALDI-TOF MS and present automation solutions for highest throughput and speed (less than 1 second per sample).
> Finally the webinar will describe how the MALDI technology is used for small molecule imaging when coupled to modern 7 T (Tesla) FT-MS instrumentation. Drugs and metabolites can be visualized and distinguished one from the other directly measured from tissue samples. These results can be linked with histological information derived from the very same tissue, giving new insights into drug action and toxicity.
The investigation of pharmaceutical substances by thermal analysis
Feb 9 2015
40 mins
Dr. Ruedi Riesen & Santosh Dandekar
Thermal Analysis is often used to investigate pharmaceutical substances. Polymorphism, pseudo-polymorphism, phase diagrams, stability, and purity determination can all be measured by thermal analysis.
The four main techniques of thermal analysis, DSC, TGA, TMA, and DMA are ideal for characterizing such substances. The chief advantage is that properties can be measured as a function of the temperature or time over a wide temperature range, from –150 to 1600 °C.
In this Webinar, we will show how thermal analysis is used to investigate pharmaceutical substances. We will present some typical examples measured by DSC, TGA, TMA or DMA.
Practical Application of a Rapid Microbiological Method (RMM) in Pharmaceutical
Dec 16 2014
59 mins
Scott Sutton Ph.D. and Yongqiang Zhang
The application of Rapid Microbiological Methods (RMM) in a topic that has gained interest over the past few years as pharmaceutical manufacturers investigate and look to gain improved efficiencies across all areas of their businesses – including the microbiology laboratory. This presentation will show how a rapid method can provide a solution to a common microbiological testing problem for pharmaceutical manufacturers – process water microbiology testing.
*** Presented by Yongqiang Zhang, Senior Scientist, BD Diagnostics:
Examination of the microbiological quality of water used for manufacturing pharmaceuticals is integral to current Good Manufacturing Practices (GMP) and ensuring product safety. Membrane filtration, the conventional method for assessing microbial burden in water, takes three to seven days to complete. Valuable opportunities for intervention could be missed due to a delay in obtaining test results. In this study, we assessed the effectiveness of flow cytometry as a rapid microbiology method for water analysis. The data with four representative bacteria [Burkholderia cepacia, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus] indicate that a low level bacterial presence in water can be rapidly detected and enumerated. These results highlight the potential of flow cytometry for real time monitoring of the microbiological quality of water in pharmaceutical manufacturing.
*** Presented by Scott Sutton Ph.D. – President of Pharmaceutical Microbiology Forum & Owner of The Microbiology Network
There has been excitement about the potential of RMM in QC microbiology since the ATP bioluminescence method was commercialised in the early 1970s. After 45 years however, pharma microbiology is notable for its lack of adoption of these methods. This presentation will examine this situation and offer some potential explanations, as well as recommendations for better microbiology service to the pharmaceutical industry.
Viability PCR - the next level in PCR-based pathogen testing
Nov 20 2014
56 mins
Dr. Marcia Armstrong (Global Scientific Affairs Manager) & Dr. Kathrin Wolf (QIAGEN R&D Scientist)
Live/dead differentiation of microorganisms helps to ensure safe food production
This webinar introduces viability PCR as a fast and powerful tool to analyze food samples for the presence of potentially harmful microbes. Viability real-time PCR utilises the DNA-masking compound propidium monoazide (PMA). PMA enters dead and membrane-compromised pathogen cells and binds to DNA, making the DNA inaccessible to detection by PCR. Live/dead differentiation is important for procedures such as: hygiene testing (success of decontamination processes), water testing (distinguishing between live and dead legionella for regulatory compliance), and several other important applications.
Do you want to learn more? http://www.qiagen.com/gb/landing-pages/detected-dead-or-alive-the-blu-v-way
How to implement NIR spectroscopy into the pharmaceutical processes
Oct 7 2014
61 mins
Dr. Ke Hong (Senior Project Manager, Pfizer Global Supply) & Mrs. Denise Root (NIR Marketing Manager, Metrohm USA Inc.)
Near Infrared spectroscopy as a great PAT tool for pharmaceutical processes-from raw material ID, integrated process control and to final product testing.
This webinar will focus on benefits of using NIR spectroscopy in several pharmaceutical processes. Examples of NIR application for raw material ID, process control testing and final product will be given. Challenges in implementing NIR spectroscopy in the analytical process will be discussed.
Gene editing partnerships to enhance drug pipeline productivity
Sep 25 2014
60 mins
Ronald Van Brempt (LUMC) and Mark Gerber, Ph.D. (Sigma-Aldrich)
Optimising target-based assays and streamlining hit-to-lead processes are key for a productive R&D drug pipeline. Researchers in both the pharmaceutical and biotech industries, as well as in academic environments, are increasingly searching for novel technologies and related services that enable them to both innovate and speed up their research pipeline. The creation of disease models for target validation and reporter cell lines for high-content screening assays are good examples of where one needs high-technology knowledge and cell engineering expertise to be able to efficiently create the ideal cell model in a reasonable time frame. Trying to have a grip on novel gene editing knowledge and hands-on experience is a time and cost consuming effort. For this reason, researchers are increasingly deciding to externalize that part of their work, in order to focus on target-specific research and other aspects of drug development.
In this free-to-view webinar we will discuss how the decision was taken on a knock out approach to generate iPSC disease models to more efficiently and quickly validate two potential lung cancer targets. We will also present considerations for undertaking successful cell engineering projects for high-content screening assay development and target validation.
Bio-Contamination, Risk Profiling and Proactive Response
Jul 10 2014
60 mins
James Drinkwater (Chairman, PHSS) / Tim Russell (TSI)
This webinar will give an overview of the recently released UK Pharmaceutical and Healthcare Science Society (PHSS) Technical Monograph #20- Bio-contamination, characterization, control, monitoring and deviation management in controlled/ GMP classified areas. The concept of Risk Profiling and Proactive Response (RPPR) to bio-contamination in GMP classified areas, focusing on preventing contamination and not just monitoring for compliance will be presented. How trending environmental monitoring data holistically across all supporting areas can detect an increasing risk of a contamination event in Grade A zones will be examined. In particular, the value of using real-time airborne viable particle detection as part of holistic monitoring strategy for risk escalation will be discussed.
Many organizations are pro-actively exploring Rapid Microbiological Methods (RMMs). Real-time airborne viable particle counting is an RMM that is generating great interest. The potential opportunities of improved product quality and efficiencies, whilst maintaining patient safety are too significant to ignore. Cases where this technology is providing value today in a pharmaceutical manufacturing environment will be presented. Included will be a brief discussion of critical performance characteristics of real-time viable particle detectors which should be considered when selecting an instrument to monitor GMP classified areas.
Food contamination an issue? – Discover solutions for your everyday preparation
Apr 10 2014
74 mins
Sabrina Moret (Associate Prof., Udine Uni.) / Duncan Goodwin (Director, NSF) / Susanne Feifel (Product Group Manager, Buchi)
This webinar focuses on new methods and applications in food contamination analysis, bringing together some of the leading experts in food contact materials (FCM) and provides an interactive learning environment for scientists working in this field.
As food quality and food integrity has become a major topic for the consumer, the penetration path of contaminants in our food chain deriving from the food production and/or the food packaging and storage conditions is gaining attention. Fast and reliable ways of sample preparation and analysis are discussed showing up-to-date examples and how the regulations are applied.
** Meet the speakers **
- Sabrina Moret (Associate Professor, Dept. Food Science, University of Udine)
- Duncan Goodwin (Director of Technical Services, NSF)
- Susanne Feifel (Product Group Manager for Kjeldahl, Elemental Analysis and Extraction, BÜCHI)
** What will you gain from this webinar? **
- You will be provided with tangible ways to streamline your sample preparation to detect mineral oil hydrocarbons in cardboard and food as well as bisphenol A in canned food.
- BUCHI´s solutions for these applications are presented using examples from industry.
- Furthermore, you will learn about health and safety risks in the field of food packaging and storage. This will be linked to up-to-date information from the leading regulatory authorities.
Detection, quantification and visualisation of protein interactions by HCS
Apr 8 2014
59 mins
Dr. Bernhard Ellinger (European ScreeningPort) / Thomas Juehne (Sigma-Aldrich)
Alongside established drug target classes, innovative approaches are addressing previously undruggable target classes such as protein–protein interactions. This webinar will provide an overview of how compound profiling using the PLA® (Proximity Ligation Assay) technology can be used for in situ analysis of protein interactions by high content screening as part of the Hit-to-Lead workflow, the key advantage being the ability to provide evidence for target engagement of the compound.
Proximity ligation is a highly specific and sensitive technology to monitor individual proteins, their interactions and post-translational modifications in situ. It provides single molecule resolution and objective and unbiased quantification in cells and tissues on endogenous expression levels.
Dr. Bernhard Ellinger (Principal Scientist, European ScreeningPort) will describe how the PLA technology has been optimised for use in an automated 384-well screening format with routines for automated image analysis including spot detection, localisation and quantification. He will present a case study of a small molecule drug discovery project performed in collaboration with a biotech partner. The target mechanism involved the disruption of the interaction between amyloid ß oligomers and RAGE (Receptor for Advanced Glycation Endproducts). Profiling of compounds during Hit-to-Lead stages has involved a variety of high content functional cellular assays including PLA. He will discuss the use of PLA in 384-well format as part of a Hit-to-Lead screening cascade to monitor compound-mediated disruption of this receptor-ligand complex.
Thomas Juehne (Principal Scientist, Sigma-Aldrich) will discuss Duolink®, which is based on the in situ PLA technology, a highly sensitive and selective way of direct in cell visualisation of endogenously expressed proteins and their interacting partners enabling the use of unmodified primary cells.
The following trademarks are owned by Olink AB: Duolink® and PLA®
Pharmaceutical Manufacturing Regulations: Navigating the Complexities
Jan 30 2014
67 mins
Michael A. Dotlich (Eli Lilly and Company) / Bei Ma (USP) / Dr. Claire Dentinger (Rigaku Raman Technologies)
During this webinar learn more about unconventional approaches to enhance quality programs with the use of modern handheld technology...
While regulatory enforcement agencies around the world have increased scrutiny on quality assurance/quality control programs, pharmaceutical manufacturers are increasingly looking for ways to lean out the manufacturing process without compromise to product quality. This push and pull conundrum has manufacturers seeking guidance on global industry regulations while searching for alternatives to legacy quality practices. With the expanding supply chain and the onset of globalization, it is now more important than ever to adjust quality programs to improve efficiency but remain keen on effectiveness for the continued promise of product quality and patient safety.
Handheld Raman technology is currently being implemented by global pharmaceutical manufacturers and regulatory agencies around the world providing an effective alternative approach to increased testing and heightened quality programs.
Combining UPLC, QbD and Software-Guided Validation for Rapid Method Development
Dec 9 2013
64 mins
Mia Summers (Sr. Business Development Manager, Waters Corporation)
Method development and validation are essential parts of the pharmaceutical drug approval process. As process modifications are made and approval criteria become increasingly stringent, changes to the validated method are sometimes necessary. A Quality by Design (QbD) approach to method development uses statistical design of experiments (DoE) to generate a robust method 'design space'. The design space defines a region in which changes to method parameters will not significantly affect the results, incorporating risk-based assessment of the final method. Rather than developing and validating a single method and proceeding through re-validation as modifications are made, a design space incorporates allowable flexibility into the method.
A QbD approach is demonstrated here in the development of a stability-indicating method, using UPLC for fast, sensitive separations, and software-driven validation. The flexibility of transferring methods between UPLC and HPLC will also be demonstrated. This streamlined approach to method development affords considerable cost savings as well as a significantly more robust and quality submission to regulatory authorities for faster drug approval.
Best Practices in Managing Microbial Excursions
Dec 3 2013
57 mins
Guenther Gapp / Tim Sandle / Dr. David Jones
Learn from industry experts some practices to help better manage the investigation process and how to design processes to minimize unnecessary excursions.
Microbial excursions as a result of an out of specification result from a quality control test can be time consuming and costly. The investigation of the root cause, analysis of the risk to the product, and determination of corrective/preventative actions take hours of manpower and resources and often are caused by issues around personnel practices, keying errors, and incubation errors.
Attendees will learn:
- What is an excursion?
- How to identify risk in an excursion
- Tools to help manage the process
RMMs for Environmental Monitoring, Validation & Viable Particle Detection
Nov 19 2013
60 mins
Marcel Goverde PhD, Tim Russell
There are critical performance characteristics of real-time viable particle detectors that should be considered when evaluating an instrument for your application. To help with these considerations the science behind a real-time viable particle counter and the information this technology can deliver in real-time will be presented. Applications where real-time airborne viable particle detection can provide value today in a pharmaceutical manufacturing environment will be examined. The webinar will go on to give an overview of different Rapid Microbiological Methods (RMMs) that can be used for environmental monitoring, their applicability and their pros and cons. An overview of the forthcoming revision of EP 5.1.6 Alternative Methods for Control of Microbiological Quality and the impact this will have on the validation requirements for RMMs will be presented.
Whatever it takes for protein analysis: Kjeldahl, Dumas, or NIR
Oct 17 2013
63 mins
François Bourdichon, William Ickes, Giovanni Campolongo & Jürgen Müller
A webinar focusing on the three most widely used technologies: Incoming or Outgoing goods inspections, at-line production control and quality control for declaration purposes.
Processed food, beverage, feed or forage pass different steps in their production cycle requiring different technologies for the determination of nitrogen or protein. Whether you need fast qualification of raw material, or precise protein declaration of processed goods; Kjeldahl, Dumas and NIR solutions can be the methods to help you. There are many factors which influence the determination of the best fitting method. Whereas Kjeldahl is a proven method for all kind of sample matrices, Dumas excels in unattended processing at high throughput, and NIR is matchless in terms of immediate and comprehensive multi-component analysis.
This webinar will address the challenges that you are faced with in determining nitrogen or protein, and will present a range of technologies deigned to assist you in your processes.
Real-time monitoring: NIR as a PAT tool
Oct 8 2013
61 mins
Dr. Volker J Frost (Metrohm NIRSystems) / Wim Guns (Metrohm NIRSystems)
The Process Analytical Technology (PAT) and Quality by Design (QbD) initiatives have been of interest for pharmaceutical manufacturing in the last years. Implementation of PAT/QbD approach involves monitoring and controlling critical process parameters that influence the critical quality attributes of the product. One of the prime processes in pharmaceutical solid dosage form is granulation and drying process. With the PAT and QbD initiatives, the FDA aims to increase efficiency of the pharmaceutical production by real-time process analysis and control. Near Infrared spectroscopy (NIRS) is well accepted as a potential PAT analyzer due to its rapid and nondestructive technique that additionally requires no sample preparation.
Metrohm is well-established in determining the moisture content by Karl Fischer titration in every conceivable type of product. To provide advance solutions for pharmaceutical customers, Metrohm now is moving forward, bringing NIRS to help customers to optimize the use of raw materials and to consistently run production closer to target specifications with time- and cost-saving analytical techniques.
During this webinar, we will be showing the use of NIR in the process that allows for monitoring low levels of residual moisture and other process constituents to yield better process control and endpoint determination. Additionally, we will be focusing on:
•Developing robust and precise method
•Minimizing implementation efforts
•Ensuring calibration model transferability between analyzers.
Advantages of Handheld Raman in the Pharmaceutical Industry
Sep 24 2013
55 mins
Dr. Katherine A. Bakeev (B&W Tek) / Sulaf Assi (Bournemouth University)
Benefits and applications of handheld Raman and how it can help to facilitate compliance with PIC/S..
This webcast will discuss the benefits and applications of handheld Raman, including the reasons the industry is interested in the technology, data integrity, method development, how samples are scanned, and challenges that have been conquered. We'll also discuss PIC/S and how it is unifying the regulatory perspective globally, currently including 41 member countries with applications of Japan and Korea under review. We'll discuss how these regulations are moving towards 100% container testing globally and how handheld Raman technology can help to achieve it, as well as the importance of validation of instrumentation and methodologies.
Metabolite Identification in the Real World
Jul 11 2013
62 mins
Dr. Axel Pähler (Hoffman La-Roche) / Marieke Teppner (Hoffman La-Roche) / Vicki Gallant (AB Sciex)
Three industry leads present strategies and tools for Metabolite Identification...
Webinars for the pharmaceutical, food & beverage industries
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Title: Accelerating and Automated Rapid Microbial Testing
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Nov 14 2012 3:00 pm
Presented by: Christof Hasse / Anna Mills / David Jones
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TV Info
Episode PremiereNovember 21, 2013
Show Period2003 - 2015
Production CompanyChuck Lorre Prod., Tannenbaum Co., Wolf Films, WB
Cast and Crew
DirectorJames Widdoes
ScreenwriterDon Reo, Susan McMartin, Saladin Patterson
Main Cast
- Ashton Kutcher as Raymond
- Jon Cryer as Alan Harper
- Conchata Ferrell as Berta
- olland Taylor
- Marin Hinkle
- Angus T. Jones as Jake Harper
- Charlie Sheen as Charlie Harper
Additional Cast
- Brian Stepanek
When Alan learns Lyndsey's boyfriend Larry has hired a P.I. to follow her, suspecting that she has been cheating on him, Alan is at first fearful of being revealed as Lyndsey's mistress. Alan's fears are alleviated when Larry shows him his P.I.'s photo of Walden as the man in question. Apparently, the P.I. took pictures of Lyndsey going into Walden's house. Alan tries talking Larry out of confronting Walden and warns Lyndsey that Larry is coming over. After Larry finds Lyndsey at Walden's house, she explains that she rented the house and hired Jenny to surprise Larry with his fantasy threesome for his birthday. Larry ends up apologizing for ever doubting her fidelity and the three of them, Larry, Lyndsey, and Jenny head upstairs while Alan is left downstairs to listen. Meanwhile, after Walden is spooked by a threatening letter left at his front door, Rose shows up at the house and tells him Larry has been stalking him. Rose offers to take him to a safe place and Walden, grateful for her help, ends up sleeping with her in a seedy motel. We discover Rose was Larry's P.I. and was behind the whole scheme.

subset: commoncrawl


text: 2 Raphael OrloveProfileFollowUnfollow Raphael OrloveFiled to: Chinese Cars Car Names 10/14/13 3:59pmEditDelete Invite manuallyPromoteXDismissXUndismissBlock for jalopnikHideShare to KinjaShare to PinterestGo to permalink The 'Urban Ark' is the best car name in the world right now. Production by China's ZX Auto is only just starting and it looks like a ripoff of a Kia Soul crossed with a Jeep Compass, but the name is still undeniably fantastic. 2 24Reply 24Discuss


text:
I agree, They are beating themselves and not ready to play every week. No consistant conditioning and training.
Conditioning of the steelers team
Posted October 13, 2012
I tend to hold mike tomlin responsible for all the teams injurys.It seems to be that the overall condition of the team is in poor shape ecept for a select few.Mike you can not be the players best friend.Work them in practice and maybe next time they wont drop like flies on the field.
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Monday, May 11, 2015
I. Approval of agenda
II. Approval of minutes
III. Public comments
IV. Course Review - Required Modifications Complete
1. RTVF-012 - Mass Media and Society (Dave Welton)
V. Course demonstrations
1. RTVF-013 - Exploring Contemporary TV (Mark Hall)
2. RTVF-015 - Introduction to Film (Mark Hall)
3. ENGL-002 - Reading Composition (Jennifer Vinsky)
VI. Reports
1. Curriculum Committee (Carrie Roberson)
2. Academy for the Development of Online Courses (ADOC) (Dan Barnett)
VII. Old business
1. Discussion - Faculty Resources for Universal Design for Learning (Katherine MacKinnon, TMI Staff)
VIII. New business
1. Associate Faculty representative (replacement)
2. Canvas Learning Management System
Information Report To Academic Senate
Next Meeting
Monday, July 27, 2015, 3:30 - 5:00 PM - LRC-244
Unapproved Minutes (will be moved to "Previous Agendas and Minutes" once approved)


text:
Like the 2007 Mercedes-Benz S550, the CL550's navigation system features a 20GB hard drive, which enables it to provide lightning-quick response and refresh times for inputs. Programming a destination is straightforward: drivers use the COMAND wheel to select state, city, or street, then use a rotary action to select the required letters and numbers. A particularly impressive feature is the system's ability to calculate addresses by ZIP code.
Like the iDrive system in upscale BMW models, the CL550's COMAND interface features haptic feedback, which gives a physical indication when the limit of a range of menu options is reached. With the destination entered, the system calculates the route in less than three seconds--a vast improvement on the navigation systems in lesser Benz models. Zooming in and out using the dial is also impressive, as the system is able to go from a nationwide view to street-level perspective as quickly as the driver can turn the dial.
Another option for zooming maps is the CL550's voice command system, activated at the push of a button on the steering wheel. Pressing the button and asking the system to zoom in or zoom out has the effect of adjusting the map by a single level of magnification at a time. Other functions of the voice command that we discovered--there was no user's manual in our test car, meaning that we had to use our favored method of trial and error when evaluating the tech--include switching between the radio, CD, and navigation screens. The voice-command system is not Acura caliber (a request to adjust the cabin temperature was met with a request for clarification), but it was gratifying to have some of our speculative commands understood.
Also to our liking is the CL550's turn-by-turn voice guidance for navigation routes, which we found prompt and accurate. When approaching a turn or an intersection, the map screen divides into two, with the right-hand side showing a detailed close-up of the road configuration--a nice feature for negotiating complex junctions.
As well as providing a convenient platform for controlling the COMAND dial, the center console-mounted pod also contains a hard-button keypad for making calls using the CL550's hands-free calling interface. While we do like this feature in theory, we were not able to use it in practice as our car was equipped with neither the $200 MHI proprietary hands-free calling interface (which works with only 5 cell phone handsets) nor the $408 Bluetooth interface that works with a mere 20 models of phone. We are not at all impressed with the necessity to splash out hundreds of extra dollars on a phone module for a car that bases at $99,000. Perhaps the most ridiculous thing on the CL550's option sheet is a $400 phone cradle that works only with the Motorola Razr--why anyone would spend that much money to tie themselves to a single (outdated) model of phone is beyond our ken.
Back to more positive subject matter, the CL550's audio system is very impressive. The standard in-dash six-disc CD changer handles regular Red Book CDs as well as MP3-encoded discs. When playing the latter, the audio system instantly indexes all the tracks on the disc, making them available in list form on the LCD screen. The driver can then use the COMAND dial to navigate the entire library of tracks at a glance. In addition to MP3 discs, the audio system can handle DVD Audio discs, but WMA-encoded discs are not accepted. All sources play back via the CL550's 600-watt, 11-speaker digital surround sound system, which delivers startlingly clear and crisp audio reproduction.
Under the hood
"Where do you put the key?" asked the parking attendant as we went out for our first test drive. It's a good question. Our tester was equipped with the Mercedes Keyless Go package that enables you to get into the car and fire it up without having to take the key from your pocket. The CL550's 5.5-liter V-8 engine is called into life with a touch of a chrome pushbutton start, giving the driver access to plenty of performance potential.
With net power of 382 horsepower and net torque of 391 pound-feet, the CL550 can get itself from zero to 60mph in just 5.4 seconds--no mean feat for a car with a curb weight of 4,360 pounds. Like many of Mercedes' high-end 2007 model-year cars, the CL550 comes with a seven-speed, driver-adaptive transmission, which apparently learns the driving style of whoever is behind the wheel, adjusting the timing of up- and downshifts accordingly.
For those who wish to adjust their own shifts in more spirited driving conditions, the CL550 features manumatic shifters on the back of the its steering wheel. As a testament to the spirited driving that can be done with the shifters, your correspondent was flagged down by the California Highway Patrol and given a speeding ticket while driving in manumatic mode.
Performance and safety technology on the 2007 Mercedes CL550 are almost as plentiful as the car's cabin gadgetry. Like the 2007 SL550 that we reviewed last month, the CL550 comes with Mercedes' Active Body Control (ABC) suspension system that's designed to reduce body roll in cornering, accelerating, and braking. Using 13 sensors placed around the vehicle, the ABC system theoretically detects and counteracts vertical- and transverse body roll by regulating the suspension via hydraulic servos located at each corner. Unlike the ABC system on the SL-Class, which has a separate setting for Sport mode, the CL550's ABC appears not to be adjustable. One performance feature that can be adjusted is the CL550's automatic shifts, which can be set to either Sport or Comfort modes depending on your mood.
For having such a large engine, the CL550 displayed passable gas mileage in our week-long test drive. Over 200 miles, we saw an average gas mileage of around 20mpg in mixed city and freeway driving.
Driving the CL550 around town, we found its power-assisted, speed-sensitive, rack-and-pinion steering a little too light for our liking: we understand that the CEOs and Hollywood agents likely to buy this car don't want to do any more work than they have to, but we would have preferred a little more resistance and feedback to remind us that we were actually driving. In fact, if you prefer outsourcing your driving duties, the CL550 is the car for you. As part of the $5,650 Premium II package, the CL550 comes with Distronic Plus adaptive cruise control, which enables drivers to peg their speed to that of other cars on the freeway. And one of the most innovative safety technologies on the car is the as-standard Pre Safe system. Pre Safe works by monitoring data from the car's braking- and electronic stability systems. If the systems suggest that the car is getting out of control, the car automatically adjusts a number of interior settings to minimize the effects of any potential impact: measures include adjusting the driver- and front passenger seats for more effective airbag deployment; inflating the seat's outboard side bolsters; and closing the windows and sunroof. Fortunately, we did not get to see any of these functions in action.
In sum
Our 2007 Mercedes-Benz CL550 came with nearly every available option. As well as Distronic Plus ($2,850) and a heated steering wheel ($450), we got the $5,650 Premium II package, which includes active ventilated front seats, dynamic multicontour front seats, a back-up camera, Night View Assist, and Keyless Go. With a gas-guzzler tax of $1,300, a destination fee of $775, and a base price of $99,000, our tester claimed the title of CNET Car Tech's most expensive review vehicle ever, with a price tag of $110,925.
The CL550 is a car at the crossroads of consummate luxury, admirable performance, and advanced onboard and driving technologies, although most people will need a second mortgage before they start to think about owning one.


text:
The following is an archive of a post made to our
'vox mailing list'
by one of its subscribers.
So the monthly social meeting is tonight, at Crepeville as usual.
Unfortunately I am not going to make it, but don't let that stop you
from having a great time.
Henry House
+1 530 753 3361 ext. 13
Please don't send me HTML mail! My mail system frequently rejects it.
The unintelligible text that may follow is a digital signature.
See <http://hajhouse.org/pgp> to find out how to use it.
My OpenPGP key: <http://hajhouse.org/hajhouse.asc>.
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text:
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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
46 year old man | Lake Mary, FL, USA | Seeking women 25-50 within 50 miles of Orlando, FL
Active within 24 hours
Dear person of interest, The grocery store just has not panned out at all. I have been described an energetic, outgoing and spoken professional free thinker who has a mind for doing what is right and humble in pursuit of life and happiness. My mother would say that I am good catch who thinks family is important. Sorry, if you are not family oriented...I am not the guy for you. So more if you wish to continue reading. Goal-oriented in both life and business. Adventurous compared to most men. Veteran of the US Army, go 82nd Airborne. I am relatively fit as I tend to be active. I own a small business which I grew from nothing but a telephone line and a laptop. I am very socially active in our community, I have been blessed and humbled with the opportunity to help others. I work with battered women in the Orlando area to help them gain confidence, move on with their life and gain employment. I have always volunteered since my early childhood days and try to encourage. We all have time, we can share this free asset. I am a Trinidadian by birth and a US Citizen by love and devotion. Graduated from Boston College. Well, I really want to know you better and I will answer all your questions with answers and not questions. ok, ok....enough from me. The ball is in your court and thanks again for reviewing my profile! Good luck and may you find happiness.
Alumni connections , Book club , Camping , Coffee and conversation , Business networking , Cooking , Dining out , Fishing/Hunting , Gardening/Landscaping , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing cards , Playing sports , Political interests , Religion/Spiritual , Shopping/Antiques , Travel/Sightseeing , Video games , Volunteering , Watching sports , Wine tasting
Aerobics, Auto racing / Motorcross, Baseball, Basketball, Billiards / Pool, Bowling, Cycling, Dancing, Football, Golf, Hockey, Inline skating, Martial arts, Other types of exercise, Running, Skiing, Swimming, Tennis / Racquet sports, VolleyBall, Walking / Hiking, Weights / Machines, Yoga
I exercise 3-4 times per week.
I have Cats, Dogs
I like Birds, Exotic Pets, Fish, Horses, Other
Middle of the Road
I enjoy traveling, oversees more than on a tank of gas (which is cool too)
Boston College, Chestnut Hill, MA
Lately, I like Hawaii 5-0, love Sushi and entertaining the woman that I am with.
My free is to spend it with the woman that captures my heart and attention. Let the passion flow and enjoy the spice of life as we live life to the fullest.
The Complete Kama Sutra....awesome stuff.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'10" (177cms)
|3'0" (91cms) to 8'11" (271cms)
|Body type:
|Athletic and toned
|Slender, About average, Curvy, Athletic and toned, A few extra pounds, Stocky
|Black, Blue, Brown, Grey, Green, Hazel
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Salt and pepper, Silver, Dark blonde, Grey, Platinum
|No Way
|No Way, Occasionally, Cigar aficionado
|Social Drinker
|Social Drinker
|Financial / Accounting / Real Estate
|Administrative / Secretarial, Artistic / Creative / Performance, Executive / Management, Financial / Accounting / Real Estate, Labor / Construction, Legal, Medical / Dental / Veterinary / Fitness, Political / Govt / Civil Service / Military, Retail / Food services, Retired, Sales / Marketing, Self-Employed / Entrepreneur, Student, Education / Teacher / Professor, Technical / Science / Computers / Engineering, Travel / Hospitality / Transportation, Other profession, Nonprofit / Volunteer / Activist, Law enforcement / Security / Military, Fashion / Model / Beauty, Architecture / Interior design
|$100,001 to $150,000
|$25,001 to $35,000, $35,001 to $50,000, $50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married, Widow / Widower, Currently Separated, Divorced
|Have kids:
|Yes, and they sometimes live at home (1)
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|Not sure
|Definitely, Someday, Not sure, Probably not, No, No, but it's OK if my partner has kids
|East Indian, Latino / Hispanic
|Asian, Black / African descent, East Indian, Latino / Hispanic, Middle Eastern, Native American, Pacific Islander, White / Caucasian, Other
|Spiritual but not religious
|Agnostic, Atheist, Buddhist / Taoist, Christian / Catholic, Christian / LDS, Christian / Protestant, Hindu, Jewish, Muslim / Islam, Spiritual but not religious, Other, Christian / Other
|PhD / Post Doctoral
|High school, Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


text:
Earnhardt Jr. wins at Daytona in front of Dillon's vicious crash
One fan was taken to the hospital after Austin Dillon's car flew into the catchfence.From The Marbles
- AskThis.orgSponsored
3 Best Luxury 2015 SUVs
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Japan football fans turn to drink as 'Nadeshiko' sink
Madoka Kataoka was on her third beer of the morning on Monday even before Japan kicked off against the United States in the women's World Cup final. A quarter of an hour later, a little after eight in the morning, she had switched to something stronger after a Carli Lloyd wonder goal from the…AFP
The Pros and Cons of the 'Sexy' Sports Bra
All I've got is one woman who has delicately tucked the back of her shirt under her sports bra. Related: The 15 Sexiest Sports Bras I've been seeing flashy sports bras on my Instagram feed and in e-commerce emails in recent months. To the dismay of those who prefer unremarkable workout clothes, the…Yahoo Style
David Ortiz did something no Boston first baseman has ever done Sunday
David Ortiz got a rare start at first base and wound up making history.Big League Stew
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Lakers plan to sign Lou Williams, Brandon Bass
LOS ANGELES (AP) -- The Los Angeles Lakers say they plan to sign guard Lou Williams, last season's Sixth Man of the Year, and forward Brandon Bass.The Associated Press
Big moves made, but dealing isn't done in NBA free agency
LeBron James is available. LaMarcus Aldridge came off the board Saturday when he committed to San Antonio, highlighting the holiday weekend fireworks. DeAndre Jordan had already decided on Dallas, placing two of this year's biggest prizes deep in the heart of Texas.The Associated Press
The Philadelphia 76ers are hoarding draft picks like crazy — here's every future pick they own right now
With the Philadelphia 76ers' recent swindle of the Sacramento Kings, general manager Sam Hinkie...Business Insider
Enveloped in controversy, Solo leaves as World Cup winner
VANCOUVER, British Columbia (AP) — Hope Solo walked out of BC Place on Sunday night with two pieces of coveted hardware and for the time being, more focus on her skill as a goalkeeper and less on her off-field travails.Associated Press
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Who is the richest person in your state? Find out!
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Remember When Hope Solo Drove a Corvette Pace Car?
Fun fact: U.S. women's goalie Hope Solo has been stopping opponent goals for the United States since 1996 when she was a member of the U16 team. Another fun fact: she also likes to drive Corvettes on the race track. Fast. In honor of tonight's big World Cup game vs Japan, we wanted to throwbackBoldride
NASCAR fans defend, display Confederate flags at Daytona
Steven Rebenstorf has numerous flags flying atop his canopy tent inside Daytona International Speedway. The Confederate flag is front and center. ''They'd have to come and get it,'' Rebenstorf said Saturday, pointing out that his American flag purposely flies a few inches higher than the rest.The Associated Press
Countdown to UFC 189: Chad Mendes vs. Conor McGregor
Go into the training camps of Irish sensation Conor McGregor and Team Alpha Male's Chad Mendes as they both prep for their UFC featherweight interim title bout in the main event at UFC 189 in this edition of Countdown.UFCcom Videos
Woods goes bogey free for first time since 2013
Tiger Woods fired his first bogey free round since 2013 on Sunday, closing with a three-under par 67 in the final round of The Greenbrier Classic. The former world number one snapped a string of 55 straight rounds with a bogey or worse -- a stretch dating back to his last bogey free round at The…AFP
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Japan emotional after World Cup loss
VANCOUVER, British Columbia (AP) — Japan clearly was not ready for Carli Lloyd.Associated Press
NBA Landscape Survey
Ryan Knaus surveys the entire free-agent and trade landscape, and examines the fantasy fortunes of LaMarcus Aldridge and DeAndre Jordan.Rotoworld
After Triple Crown, a new world greets Victor Espinoza
HALLANDALE BEACH, Fla. (AP) — This is the new reality for Victor Espinoza.Associated Press
Sources: Lakers to sign Brandon Bass, could trade Nick Young
The Lakers have reached agreement to sign Brandon Bass, but could trade Nick Young or other players to clear cap space.Yahoo Sports
- Ask.comSponsored
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Women's World Cup Final Live: United States vs. Japan
The Americans shoot for their third world title against defending champion Japan in a rematch of the 2011 World Cup final.FC Yahoo
Rosberg fooled by Hamilton pit stop masterstroke
Nico Rosberg believed he was on course to win Sunday's British Grand Prix when Mercedes team-mate Lewis Hamilton made his decision to pit for intermediate tyres in the rain-swept closing laps. "When it started raining, I felt great," said Rosberg. "I was really able to attack and pass both Williams…AFP
Abby Wambach delivers incredible 7-minute monologue about her career before Women's World Cup final
Before the final World Cup game of her career, US women's national team legend Abby Wambach...Business Insider


text:
Create 2D games with the first game engine integrated directly into the iOS SDK: Sprite Kit.
Use Flash Professional CS5 to create a game to play on iOS devices, utilizing device hardware like the accelerometer and integration with a local database.
"lynda.com has enabled me to grow my skill set at an affordable price. I find the business profiles/documentaries inspiring and the training is top notch." —Shawn C.
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text:
I Have seen paolo (pret a 3d) using dual views on DAZ in his videos, Hows is this activated? im using DAZ 4.5.
Noob with a big heart.
Link for example please. Or a screen capture whichever is easier.
Exile, Drows Walk: A Tale of Jaderail starts here. Free pulp fiction at its Fantasy best, Updated 2/3/14.
Proud Member of the Bald Wizards Club My stuff at DeviantArt
http://www.youtube.com/watch?v=lVch_4d8C3w look in this one JD.
Ahh.. For some reason I was thinking Animation. But what you want is in Window>ViewPorts just pick what you need when you need it. You can change cameras ect… in each one you have open.
DOH! how silly of me. Thanks a bunch.


text:
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The way you treat your clients is a direct result of the culture you have at your organization. More
Snow and ice removal companies that diversify their contracts stand out in their market. More
When it comes to hiring, make sure to focus on the most important part: interviewing. More
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Greenwise Organic Lawn Care uses a non-traditional approach to its snow removal services. More
PELLA, Iowa – Vermeer has introduced a new walk-beside service plow with trencher for contractors who need a machine that can work in tight... More
Plants for drought-weary growers, landscapers and consumers. More
Bret Lieberman will lead the brand in North America, effective immediately. More
Pam Prior will manage the ground care's network of dealers and distributors worldwide. More
The company's entire retail line will be available through the lawn and garden distributor. More
John Deere Green Tech will sell Rain Bird's products within the states of Texas and Oklahoma. More
The HS 82 and HS 87 use 20 percent less fuel than previous models. More
The site will help gardeners shop for planters and furnishings that fit their specific needs. More
Stay on top of up-to-the-minute news and views from around the lawn and landscape industry.
Water expert Richard Restuccia gives us a first-hand account of the impact of the drought in California, and what it means for the national landscape industry in the future. Landscapers need to take advantage of the opportunity and present themselves as the solution to the drought, not the cause. More


text: No recent wiki edits to this page. Catman meets his son for the first time Thomas Jr. is the son of Catman and Cheshire. Thomas Blake, Jr. is named after his father, Thomas Blake or Catman. His father first met him when the Secret Six went to Cheshire's hideout in the Himalayas, where Cheshire revealed the boy to his father. He was recently kidnapped, as a way to get at his mother. His kidnappers had him adopted. The man funding the kidnapping told Catman that it was better this way, that no one would kidnap him again, and he would be safe. Catman kills his son's kidnappers, but leaves his son where he is.


text:
Bryzgalov joins Ducks on tryout
ANAHEIM, Calif. — A familiar face will be arriving in Southern California just in time to see his new (or old) team face the Flyers. Goaltender Ilya Bryzgalov will join the Anaheim Ducks on a tryout contract this week, the Ducks confirmed an ESPN report on Wednesday. Regular Ducks backup Jason... Read more
Flyers chat with Frank Seravalli
Join Frank Seravalli of the Daily News as he takes your Flyers questions in a live chat, beginning at 1 p.m. Friday. Get the full Frequent Flyers experience at PhillyDailyNews.com. Read more
Full transcript: Eric Lindros, John LeClair Hall of Fame speeches
Below is a transcript of the Flyers' Hall of Fame induction speeches by Eric Lindros and John LeClair on Thursday night: LINDROS: What a thrill to be back. Good evening. It's nice to be back in the rink that we had such a good time playing in, and playing for you. Before we get started tonight... Read more
Flyers' Craig Berube settles Michael Del Zotto before return to New York
NEW YORK — As the Flyers' practice wound down on Tuesday, amid the confusion about Claude Giroux, coach Craig Berube turned his attention to defenseman Michael Del Zotto. Tonight is Del Zotto's first game back at Madison Square Garden, after spending the last four and a half seasons... Read more
Flyers' Claude Giroux likely to miss at least two games
THE MYSTERY surrounding Claude Giroux took another strange turn yesterday when he did not report for practice. After general manager Ron Hextall declared Giroux to be "fine" on Monday night, Giroux will likely miss at least the next two games with what the team is calling a "lower-body" injury. Tonight... Read more
Flyers' Claude Giroux OK after being evaluated by team doctors
Andrew MacDonald and Luke Schenn were practicing, having been upgraded to any-day-now status by general manager Ron Hextall. Even Michael Raffl, originally declared out until sometime around mid-December with a right foot injury, took a quick twirl on the ice for the first time since Nov. 5. For... Read more
Has Andrew MacDonald suffered a setback in recovery?
Flyers defenseman Andrew MacDonald did not skate for the fourth consecutive day on Wednesday, leading many to wonder whether he suffered a setback in his recovery from a right knee injury. MacDonald, 28, skated on Nov. 6 for the first time since his Oct. 22 injury, but has rarely been seen since. Coach... Read more
Flyers' Michael Raffl out 6 weeks with lower-body injury
The Flyers will be without their co-leading goal scorer for the next 6 weeks. General manager Ron Hextall announced on Wednesday forward Michael Raffl will miss 6 weeks with a "lower-body" injury that came as a result of a blocked shot against the Oilers. Raffl awkwardly went down after Mark Fayne's... Read more
Flyers chat with Frank Seravalli
Join the Daily News' Frank Seravalli as he takes your Flyers questions in a live chat, beginning at noon on Tuesday. Get the full Frequent Flyers experience at PhillyDailyNews.com. Read more
Coburn's foot feeling better this time around
Defenseman Braydon Coburn skated for approximately 30 minutes on Monday, his first on-ice workout since taking pregame warmups in Chicago on Oct. 21. After nearly two weeks of rest, the difference in Coburn's sore left foot has been night and day. "It was good to get back out there and... Read more
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text:
The Celts: History, Life, and CultureHardback
List price $202.49
You save $6.29 (3%)
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Dispatched in 2 business days
When will my order arrive?
- Publisher: ABC-CLIO
- Format: Hardback | 898 pages
- Dimensions: 185mm x 259mm x 69mm | 2,318g
- Publication date: 8 August 2012
- Publication City/Country: Santa Barbara
- Edition statement: New.
- Illustrations note: 60
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Product description
The study of Celtic history has a wide international appeal, but unfortunately many of the available books on the subject are out-of-date, narrowly specialized, or contain incorrect information. Online information on the Celts is similarly unreliable. This two-volume set provides a well-written, up-to-date, and densely informative reference on Celtic history that is ideal for high school or college-aged students as well as general readers. The Celts: History, Life, and Culture uses a cross-disciplinary approach to explore all facets of this ancient society. The book introduces the archaeology, art history, folklore, history, linguistics, literature, music, and mythology of the Celts and examines the global influence of their legacy. Written entirely by acknowledged experts, the content is accessible without being simplistic. Unlike other texts in the field, The Celts: History, Life, and Culture celebrates all of the cultures associated with Celtic languages at all periods, providing for a richer and more comprehensive examination of the topic.
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"Virtually all aspects of Celtic life are touched upon in these 800-plus entries on archaeology, art, history, music, mythology, and language and literature... While certainly readable for high school or college age students, the information is in-depth and is perhaps a better fit for more advanced scholars who have a familiarity with Celtic languages and geography; either way, a fascinating browse." - Library Journal "The variety of topics relating to Celtic civilization is quite astounding... Recommended for academic and large public libraries-as well as other libraries where there is a need for Celtic resources-to fill the gap in this popular growing area of interest." - Booklist, Starred Review "This latest accessible and affordable addition to the body of reference works in Celtic studies presents the full range and impact of this civilization in Western Europe and worldwide ... The 800-plus entries present Celtic culture's unique features in both national and regional perspectives... Summing Up: Recommended." - Choice "The Celts: History, Life, and Culture is a major reference work, suitable for libraries that support graduate level or substantial undergraduate programs in Celtic studies. Those that could not afford the earlier five-volume set will certainly want this. Even those that do have the earlier and more complete publication may want to consider this as well for its updated entries and bibliographies." - ARBA "[An] impressive addition to ABC-CLIO's library of reference works ... a useful ready-reference handbook ... sturdily bound, well-designed, and nicely printed." - Journal of Folklore Research


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Suunto A-30L Compass
Suunto A-30L Compass
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The A-range of recreational compasses is a series of handy, well designed, navigational aids which are assets in any environment. All four models in the series (A-10, A-20, A-30 and A-40) are compact, high-accuracy instruments made from durable, clear, scratch resistant acrylic that have been ergonomically designed to fit into the palm of your hand for optimum ease of use. These light-weight compasses feature a fixed declination correction scale as well as a patent-pending lanyard snap-lock enabling the compass to be easily detached from the lanyard.
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Jasper County Advertiser
HUNDREDS OF VEHICLES PRICED AT OR BELOW INVOICE! NOW THROUGH JANUARY 2 ND 2013 CHRYSLER 200 3 ONLY LEFT! TOURING's ALL 2013 VEHICLES PRICED BELOW FACTORY INVOICE! 2013 DODGE DART 3 ONLY ING! N I REMA SXT'S Y! HURR 2013 CHEVY SONIC's 3 ONLY ! T F LE ALL BELOW FACTORY INVOICE! AS LOW AS $18,068! 2 ALL BELOW FACTORY INVOICE! AS LOW AS $15,466! 2 ALL $6,000 OFF MSRP! AS LOW AS 1 $17,780! 2 ALL 2014 VEHICLES PRICED AT FACTORY INVOICE! CHEROKEE SPORT FWD ALL N EW 2014 JEEP 6 HER E AN D COM ING! 2 MALIBU LT $ INVOICE PRICE MSRP $25,600 2014 CHEVY SPARK 3 2014 CHEVY $ Y 195/ mo 3 ONL 4 $ 23,641 AS LOW AS 21,890 $ 12,995 ONLY Kelly Blue Book's 10 Best Small SUV's Under 25K Kelly Blue Book's #3 Best Car Deals Kelly Blue Book's 10 Best Cars for Back to School ALL NEW 2014 CHEVY SILVERADO 1500 DOUBLE CAB 4x4 MSRP $41,865 We guarantee that we can get you approved, even if you have been recently divorced, filed bankruptcy and even had your car repossessed. Call us today, we'll help you find a car that fits your budget! INVOI CE PRICE $ CREDIT APPROVAL CALL 641-236-3181 GUARANTEED 2013 CHEVY SUBURBAN LTZ MSRP $63,495 35,335 3 INVOI CE PRICE $ 53,855 3 SHOP 24/7 @ www.WesFinch.com! "IOWA'S BEST USED CAR BUY" Buyers find more than their money's worth with CHEVROLET IMPALA Never before has Iowa seen so much activity on pre-owned cars. Wes Finch Auto is selling the luxurious mid-size 2013 Impala for as little as $13,980!!! 2 2012 CHEVY VOLT DEMO #111370 MSRP $45,269 THAT'S ALMOST HALF THE ORIGINAL $26,595 FACTORY STICKER PRICE ON A 2013! HURRY IN WHILE SUPPLIES LAST! NINE AT $13,980 ONLY 23 IMPALAS AVAILABLE! 2 $ All come with a life time powertrain warranty that stretches beyond the factory's coverage. 27,238 JUST 3 SALES PRICE INCLUDES $7,500 TAx CREDIT5 Check Out the Wes Finch Advantages! 1 True Peace of Mind...Forever LIFETIME WARRANTY ON 6 ALL NEW & PRE-OWNED VEHICLES! 2 SOLUTIONS FOR ALL CREDIT SITUATIONS! 3 WE'LL BUY YOUR VEHICLE WHETHER YOU BUY FROM US OR NOT! 4 WE GUARANTEE THE BEST PRICE ON NEW VEHICLES OR WE'LL GIVE YOU $ 1,000 Hours: Mon & Thu: 8am - 8pm • Tues, Wed, Fri: 8am - 6pm • Sat: 8am - 4pm 866-427-6665 • www.WesFinch.com On select models; see dealer for details. 2Example vehicle 2013 Dodge Dart SXT (stock #113207); example vehicle 2013 Chevy Sonic LS (Stock #113129); example vehicle 2013 Chrysler 200 Touring (stock #11329); example vehicle 2014 Jeep Cherokee Sport FWD (stock #11462); example vehicle 2013 Chevy Impala LS (stock #213219); excludes tax, title, license and dealer fees. See dealer for details. 3Prices quoted are after rebate plus tax and fees. Program subject to change without notice. Prior sales excluded. Excludes tax, title, license and dealer fees. 4 With approved credit; payments are based on 2.49% APR for 72 months with $0 down, plus tax and fees. 5See your tax advisor to see if you qualify for $7,500 tax credit on 2012 Chevy Volt (most everybody does). 6All pre-owned vehicles have Warranty Forever if under 100,000 miles. 1 Highway 146 South • Grinnell


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Light the way to your garden paradise with this heavenly angel. Blue glass ball glows with a solar powered light that shines for up to 10 hours on a full charge. Uses one rechargeable AA battery (included) and has an on/off switch. Crafted of resin in exquisite detail. 8" w x 19 1/2" h x 5" d.
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Tagged News for Congress
ITU celebrates 25th anniversary
01/04/14 - April 1st, 2014 marks the International Triathlon Union's 25th anniversary, and a wide variety of events and projects will be taking place this year at ITU events worldwide to mark the occasion. From the... |Full Story
PATCO Congress
15/10/10 - The 18th Congress of the Pan American Triathlon Confederation (PATCO) convened in Puerto Vallarta, Mexico with 18 countries present. Alberto Fonollosa, PATCO President, opened Congress with a warm... |Full Story
PATCO Governance Training
13/10/10 - 28 representatives from 14 countries of the Americas took part in a Governance Training Seminar conducted by David Styers of BoardSource, a Washington based agency that supports best practice and... |Full Story
Milestone Congress for Oceania
08/10/09 - In September 2009 the Oceania Triathlon Union achieved a milestone for the sport in the region with a Congress at the Gold Coast, Australia. In attendance at this Congress where representatives from... |Full Story


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Originally published in Interiors & Sources
Roots' new headquarters reflects the Canadian retailer's vision and need for flexibility and openness.
Flexibility is a key element in any design project, and the new headquarters for Roots, one of Canada's leading manufacturers of clothing, furniture and other items, boasts flexibility throughout the facility. The company's new home in Toronto successfully reflects its culture and work processes in an environment that has won rave reviews from its staff.
"Don Green and Michael Budman, Roots' founders, were very involved in the design
process and clearly articulated what they wanted," says Donna Wood, studio director
for Bullock Associates, also of Toronto, the project's architect and interior designer. "We were expected to create an environment that would provide the flexibility to meet the company's current requirements while also addressing potential future needs."
Roots also had three other
key project goals, according to Wood. The first objective was
to consolidate the company's existing four locations into one facility. Remaining goals centered around creating a clean, bright and contemporary atmosphere that would reflect the company's values and design focus.
The answer was to move into an old warehouse—resulting in an adaptive re-use project located in an area of the city that is being revitalized. Roots occupies 60,000 square feet on two floors that are connected by both an elevator and two staircases—one in the front of the building and one in the middle of the space. Sales,
IT, and accounting are located
on the first floor, while design, merchandising and purchasing
are located on the second floor.
"The windows in the structure were inadequate," says Wood. "One of our first steps was to add large windows to the
building on the first floor where the loading dock was originally located. This full expanse of glass in two-story sections allows natural light to generously flow into the space and was integral to creating a bright, open environment."
The Bullock Associates design team selected a virtually all-white color palette for the headquarters, which provides an excellent backdrop for displaying Roots' products while also addressing the goals for brightness and a contemporary feel.
The reception area features a desk with clean simple lines, a porcelain tile floor with an area rug, and an intimate seating area that includes chairs and tables manufactured by Roots. The company's founders sat around a fire discussing business ideas when they were younger, and the reception area's fireplace ties to their history while adding warmth to the space on cold winter days. A showroom on the other side of the fireplace provides space for client meetings and presentations.
Bullock Associates recommended leaving selected structural members exposed throughout the space—a tactic that begins in the reception area. Structural steel bracing
and piping were left uncovered and painted white. The approach adds visual interest without being overwhelming.
Employees can grab a bite to eat or a cup of coffee, or conduct meetings in the first-floor café. The space features sealed concrete floors and laminate-topped tables with wood chairs. Two-story glass panels were also installed in this area to brighten the space. A patio located off the café provides a place for outdoor dining when the weather is
sufficient. The café and patio can be combined to create a large area capable of accommodating fashion shows, parties or charitable events.
The desire to create an open and contemporary atmosphere resulted in the selection of ie by Teknion for the offices. The product's installation, one of the first in Canada, is an appropriate backdrop for displaying Roots' products while also meeting functional requirements.
Offices are clustered depending on a department's function and can easily be changed to meet varying employee needs. The 240 workstations, which are finished in silver and white, have a post-and-beam structure and translucent membrane screens that provide privacy without reducing the openness of the offices. Managers have higher panels than the general work areas, and were intentionally positioned for increased privacy.
Displaying and storing merchandise in the offices was addressed through several approaches. Teknion designed a series of coat rods that hang from the workstations to fulfill display requirements in individual workstations or clusters. Spaces for rolling racks and closed storage were also provided to help keep the offices from becoming cluttered.
Some elements, including ductwork and the wood ceiling, were left exposed in the offices to again add visual interest. Skylights were added above the second floor to allow more natural light into this level. Additional design features include a rolled, charcoal
carpet manufactured from felt that is both durable and aesthetically appropriate, as well as the use of acoustic ceiling tiles in select areas.
"We've heard from Roots employees that they are very pleased with their new facility,"
concludes Wood. "They appreciate the openness and believe that our design reflects the company's own design focus. The decision to consolidate from four locations into one resulted in operational benefits that make interacting between employees much easier."
Visit our website today to learn about the design flexibility of a Morton building and the endless possibilities of partnering with our designBUILD team.
Wood construction is both cost and energy efficient. Check out Morton Buildings and our designBUILD team online today to discover all the benefits of post-frame construction.
When choosing a metal-clad building for your next construction project, consider Morton Buildings, Inc., and their designBUILD team, we'll make your dream a reality.
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Our mission is to help our customers manage their buildings' energy costs, improve reliability, and enhance performance while having a positive impact on the environment.
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The BUILDINGS brand serves commercial building owners and facilities management professionals for commercial real estate. BUILDINGS brand offers its audience of commercial building owners and facilities management professionals information on the development, construction, modernization, management and operations of commercial buildings as well as the products and services needed to support such commercial buildings and facilities management. With the information we offer, we help facilities management professionals make smarter decisions for commercial buildings.
BUILDINGS delivers relevant and timely information that equips commercial building owners and facilities management professionals with the knowledge and support they need to solve critical issues; energy management, lowering operating costs, new products for commercial buildings, security, and much more.
BUILDINGS provides facilities management professionals commercial buildings tips and trends trough online webinar events (BuildingsVIP), monthly newsletters, whitepapers and case studies.
In addition to content, BUILDINGS features a comprehensive list of products and services and is your link to the companies that provide these valuable facilities management and commercial buildings resources.
You also have the opportunity to maintain your commercial buildings certifications with BUILDINGS. Continuing Education Units are available with approved content from BOMI.
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Originally written on Fox Sports | Last updated 4/4/13
Travis Wood allowed one hit over six innings and the Chicago Cubs held off the Pittsburgh Pirates 3-2 on Thursday. Wood struck out four and walked two as the Cubs won a season-opening series for the first time in four years. Wood also scored the game's first run, racing home on Starlin Castro's single in the third inning. Nate Schierholtz smacked a two-run homer in the ninth to give the Cubs some breathing room. Chicago needed it after another shaky outing from Carlos Marmol. The closer picked up his first save of the season, but only after the Pirates drew within one. Pittsburgh had the tying run on third with no outs, but Pedro Alvarez struck out and Neil Walker hit into a game-ending double play.
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Springfield Museums Press Releases
Museums Announce June Culture & Cocktails Event
May 22, 2015
On Thursday, June 4 from 5-8 pm, the Springfield Museums will present their final Culture & Cocktails event of the 2014-15 season at the George Walter Vincent Smith Art Museum.
Museums to Hold Society of William Rice Dinner
May 18, 2015
On Thursday, May 28, the Springfield Museums will hold their thirty-fifth annual dinner for members of the Society of William Rice at 6:00 PM in the George Walter Vincent Smith Art Museum.
Curious George Kicks Off Summer Exhibits at Springfield Museums
May 6, 2015
The insatiable curiosity of Curious George – the little monkey who has captured the imaginations and hearts of millions for close to 75 years – comes to life May 23, 2015 at the Springfield Museums. The new exhibit, Curious George: Let's Get Curious! will introduce young children to Curious George's world and lead visitors on a fun, meaningful interactive math, science and engineering-based adventure. The exhibit will be on view at the Springfield Science Museum through September 6, and is designed primarily for children ages 3-7 and their parents.
Museums Announce Lectures for May
April 27, 2015
The Springfield Museums' monthly tour and lecture schedule continues in May with the popular Thursday Museums à la Carte lectures, held weekly at 12:15 p.m. in the Michele and Donald D'Amour Museum of Fine Arts. Admission is $4 ($2 for members of the Springfield Museums); visitors are invited to bring a bag lunch (cookies and coffee are provided). The programs are sponsored by Big Y World Class Market. For more information about Museums à la Carte, call 413.263.6800, ext. 488. This month's lectures include:
Museums to Display Works by Local Students
April 21, 2015
The Springfield Museums will host a community art show featuring creations by local students in grades 5 through 12. Life's Impressions will be on view in the Special Exhibit Gallery of the D'Amour Museum of Fine Arts from Saturday, May 9 through Sunday, May 17; the show is free with general admission. The exhibition is funded, in part, by the Michele and Donald D'Amour Fund, established in 2008 to bring world class art exhibitions to the D'Amour Museum of Fine Arts.


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1778-1779 TOKEN Rhode Island Ship Token, No Wreath, Brass MS64 NGC....
2008 May Long Beach, CA Signature Auction #1108
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Single Finest Certified No Wreath
Rhode Island Ship Token, Breen-1139, MS64
An intermediate variety of this well known Revolutionary War medal. The blundered VLUGTENDE legend is scraped off the lower reverse, as issued, but no wreath has yet been added to the die to replace it.
Ex: F.C.C. Boyd; John J. Ford, Jr. Collection, Part II (Stack's, 5/2004), lot 265.
From The Liberty Collection of American Colonial Coinage, Part Three. (PCGS# 588)
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20 Dollars to Surf!
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