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Researchers Express Concern About Scar Tissue And Extramedullary Disease In Multiple Myeloma Patients
Published: Mar 20, 2014 1:55 pm
A team of Israeli researchers has expressed concern that surgical scars may be a particularly favorable environment for the development of difficult-to-treat extramedullary disease in multiple myeloma patients.
Extramedullary disease occurs when myeloma cells form tumors outside of a patient's bones.
The Israeli researchers also suggest that novel anti-myeloma therapies –such as thalidomide (Thalomid), Revlimid (lenalidomide), or Velcade (bortezomib) – and perhaps stem cell transplantation may foster the development of extramedullary disease in scar tissue.
The researchers describe their concerns in a recent journal article. In it, they present case reports for three myeloma patients diagnosed between 2008 and 2012 at their cancer center. The patients developed extramedullary disease in scars from previous surgical procedures.
In all three cases, the extramedullary disease failed to respond to treatment, and the patients died shortly afterward.
In addition, the researchers explore in their article reasons why scar tissue may be a favorable location for extramedullary disease to develop, and why certain novel anti-myeloma therapies may foster the development of extramedullary disease.
The article by the Israeli team is accompanied by an editorial written by three Spanish myeloma specialists, including Dr. Joan Bladé, one of Spain's leading myeloma researchers.
The Spanish authors provide additional perspective on the Israeli findings regarding extramedullary disease and scar tissue, saying "Clinicians should be aware of the possibility of this type of relapse in order to plan the best treatment …"
Limited – And Potentially Conflicting – Evidence
Given how difficult it can be to treat extramedullary disease, the concerns raised by the Israeli researchers are likely to draw the attention of other investigators.
The significance of extramedullary disease, and the possibility that steps could be taken to avoid it in certain situations, are also key reasons The Beacon has chosen to publish this review of the Israeli researchers' work. In addition, the authors provide a plausible explanation why scar tissue could be a favorable location for extramedullary disease to develop.
It bears emphasizing, however, that the evidence supporting the researchers' claims is limited. The Israeli findings are case reports. They are not results from a comprehensive retrospective study using specific criteria for the inclusion or exclusion of certain patients. Such a study would provide results providing better perspective on the researchers' claims, such as the percentage of patients who have experienced the type of extramedullary disease the Israeli authors have highlighted.
Furthermore, there is evidence contradicting some of the points the authors make.
The Spanish researchers note in their editorial, for example, that a recent study found no link between treatment with the novel agents thalidomide or Velcade and the development of extramedullary disease.
Dr. Shaji Kumar from the Mayo Clinic, who was not involved in the study, likewise told The Beacon, "There is no evidence to link extramedullary disease with novel agents, except that these drugs may be allowing patients to live longer, and hence we are seeing a phase in its natural evolution, which we could not see before."
"I agree that extramedullary disease is an emerging problem and needs specific studies to address how to deal with it," adds Dr. Kumar. "I am not certain that scar tissue-associated extramedullary disease is a significant problem."
"We are certainly seeing an increasing number of patients with extramedullary disease in our practices," Dr. Kumar added. "What is not clear is whether this represents a higher proportion, or just an increase in absolute numbers as more patients are living longer with relapsed disease."
Dr. Kumar and the Israeli and Spanish authors all agree, however, that there is a need for further research concerning extramedullary disease.
"There is no doubt that advances in research will result in a better understanding of extramedullary myeloma dissemination and, importantly, in a more effective therapy," the Spanish researchers write in their editorial.
Extramedullary disease occurs when myeloma cells form tumors outside of the bone marrow, in the soft tissues or organs of the body (see related Beacon news).
The true prevalence of extramedullary disease in multiple myeloma patients has yet to be determined. Prior studies have reported rates ranging from 7 percent to 20 percent in newly diagnosed myeloma patients, and from 6 percent to 20 percent in relapsed patients.
Previous research also has shown that myeloma patients with extramedullary disease, either at diagnosis or relapse, have a poorer prognosis than those without. However, the mechanisms underlying extramedullary disease are still not well understood.
According to the Israeli researchers, extramedullary disease in scar tissue is uncommon in cancer patients and has been rarely reported in multiple myeloma patients.
Study Design and Results
Investigators at the Rabin Medical Center in Petah-Tikva, Israel, identified three myeloma patients who had developed extramedullary disease in scars from recent invasive surgical procedures.
The patients were treated at their institution between 2008 and 2012.
All three patients had stage III multiple myeloma at diagnosis.
All three patients received induction therapy that included novel agents. One patient received melphalan (Alkeran) plus prednisone and Revlimid followed by continuous melphalan and prednisone (MPR-MP).
The other two patients received treatment with a drug combination called VDT-PACE: Velcade, dexamethasone (Decadron), and thalidomide followed by cisplatin (DCEP), doxorubicin (Adriamycin), cyclophosphamide (Cytoxan), and etoposide (VP-16). VDT-PACE was followed by autologous stem cell transplantation in both patients.
All three patients responded well to the initial treatment, with stringent complete responses in the two who underwent stem cell transplants. The patient who received MPR-MP achieved a very good partial response.
The invasive surgical procedures that caused the development of scars differed among the patients. One patient fractured a bone in his shoulder that required surgery, one patient underwent surgery to remove part of a relapsed myeloma tumor, and one patient had a tooth surgically removed. In the first two patients, the surgeries were directly related to effects of their myeloma.
Extramedullary disease was confirmed with biopsies in all three patients.
In the first two patients, extramedullary disease occurred as the only indicator of relapse before overall myeloma relapse. In contrast, in the third patient, extramedullary disease occurred at the same time as overall myeloma relapse.
All three patients were initially treated with targeted radiotherapy for their extramedullary disease. However, in all three, the disease progressed rapidly and caused death within several months.
Implications Of The Patient Cases
According to investigators, finding so many patients at one hospital in such a short period of time "might indicate an emerging and difficult-to-treat resistant disease in the era of targeted therapies in multiple myeloma."
"Alternatively," they write, "it may be an underreported phenomenon and, therefore, awareness by treating physicians should be heightened in the face of the dismal prognosis associated with these cases."
The investigators explain that they do not yet understand the exact mechanism of this development. They speculate, however, that the extramedullary disease may develop either due to accidental transfer of myeloma cells into the scar tissue during surgery, or due to the spread of myeloma cells through blood or lymph into the scar tissue after surgery.
In addition, the authors note that scar tissue "is rich in inflammatory mediators aimed to facilitate wound healing." Unfortunately, they add, "These mediators also support tumor growth and survival."
Based on their findings and the potential reasons why scar tissue could promote extramedullary disease, the Israeli researchers conclude that "Physicians treating multiple myeloma patients should be aware of this phenomenon and should consequently be careful when they select invasive procedures for these patients."
For more information, please see study by Muchtar E. et al., "Myeloma in scar tissue - an underreported phenomenon or an emerging entity in the novel agents' era? A single center series," Acta Haematologica, January 10, 2014 (online) (doi: 10.1159/000354830) (abstract) and the accompanying editorial by Rosiñol L et al., "Extramedullary myeloma spread triggered by surgical procedures: an emerging entity," Acta Haematologica, January 10, 2014 (online) (doi: 10.1159/000354833) (preview).
Related Articles:
- Pomalidomide May Be Effective In Myeloma Patients Who Develop Extramedullary Disease
- Extramedullary Disease Presents Unique Symptoms And Challenges In Multiple Myeloma Patients
- Better Treatments For Extramedullary Myeloma Still Needed
- Beacon NewsFlashes - September 25, 2013
- Non-Marrow Tumors Increase Among Myeloma Patients As Survival And Detection Methods Improve


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Here's what Al reported to us a while back! Looks like it finally got started up.
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Spring update: Blog post from Acacia Andrews
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CSU volleyball vs. Texas - NCAA tournament
CSU played in its 10th NCAA Regional Semifinal, falling to No. 2 seed Texas in Minneapolis. - 12/12/14 [Photos by Eric Miller]
CSU volleyball NCAA Regional practice
After arriving in Minneapolis, the CSU volleyball team practiced at the Sports Pavilion - 12/11/14 [Photos by Nic Hallisey]
CSU volleyball vs. Colorado - NCAA Tournament (1)
Photos from CSU's 3-2 second-round victory over rival Colorado - NCAA tournament - 12/6/14 [Photos by Dan Byers]
CSU volleyball NCAA tournament practice
CSU held its final practice before taking on Denver in the first round of the NCAA tournament - 12/4/14 [Photos by Don Reichert]
CSU volleyball vs. Wyoming (2)
Photos from CSU's regular-season finale, including Senior Night and the Mountain West trophy presentation - 11/26/14 [Photos by Tom Waido]
- Bom Squad MVP (2013)
- Mountain West Academic All-Conference (2013)
2014 (SOPHOMORE): Started 25 matches for the Rams, averaging 1.48 kills and 0.90 blocks per set... Finished Mountain West play ranked 12th for blocking (1.05 per set)... Led the MW in kills and blocks for conference matches after the first week of conference play, averaging 2.14 per set in both categories (9/28)... Set a career best with nine blocks in a four-set win at Utah State (9/25)... Also added a season-high-tying nine kills... After ties at six consecutive points in Set 2, CSU went on a 5-0 run, including three blocks from Andrews... Two days later, led CSU with six blocks at Boise State (9/27), in addition to six kills on .417 hitting (6-1-12)... Tallied a match-best seven blocks, in addition to a season-high-tying nine kills on .350 hitting, at San Diego State (10/30)... Had seven kills and zero errors in wins over UNLV (10/2; 7-0-14) and UTEP (9/13; 7-0-12)... Late in Set 2 at No. 18 Arizona State, had a kill and two blocks during a 7-0 run to help the Rams come from behind and take a 2-0 lead in the match... Had a season-high-tying nine kills, in addition to a team-leading three blocks, in a win vs. No. 9 BYU (9/12)... In a come-from-behind Set-2 victory, had a kill and block during a 4-0 run to give CSU the lead... Had six kills on her first seven swings at Northern Colorado, finishing the night with seven (.455 hitting) and three blocks... Hit .471 (4-0-7) in a three-set win over UC Santa Barbara (8/30)... All four kills came in the first set, the final one giving CSU a 21-20 lead - one it would hold for good after 12 ties and five lead changes.
2013 (FRESHMAN): Appeared in 27 sets, recording 39 kills and 16 blocks... In her first collegiate start (at Denver, Sept. 10), posted 10 kills on .500 hitting, in addition to a team-most six blocks... Tallied nine kills and zero errors at a .692 clip in a come-from-behind win at Utah State (Nov. 2)... In matches where she appeared in at least three sets, averaged 2.60 kills per set on .488 hitting, in addition to 1.10 blocks... Named the team's Bom Squad MVP, given annually to the scout team's top player... Earned Mountain West Academic All-Conference honors.
2012 (REDSHIRT): Sat out the 2012 season, using a redshirt.
HIGH SCHOOL: Is a 2012 graduate of Norman North High School... Spent her first three years of high school homeschooled before attending Norman North as a senior and becoming an all-state alternate... Propelled the Timberwolves to the state tournament and an eighth-place finish... Received three all-tournament honors throughout the year... Named her team's best offensive player... As a junior in 2010, led her team to the homeschool national championship... Named to the HomeSchool Volleyball All-America team... Earned three total letters... Played club volleyball for Peak Performance... Member of the National Honor Society.
PERSONAL: Born April 19, 1994, in Austin, Texas... Raised in Norman, Okla. ... Oldest of four siblings born to Donnie and Jennifer Andrews... Grew up in the same city as Head Coach Tom Hilbert, and the two had the same violin teacher... Majoring in anthropology.
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JPs vote 13-0 to levy per-inmate daily fee on all cities using jail
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1959 Nov 30: Letter from Leon Campbell to R.V. Ramsay
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Red Sox fans are just getting used to the idea of Mike Cameron patrolling left field for the Red Sox next season. And for many, it's not a particularly sexy idea.
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Former IUP roommates Marie Zettl Marshall '72 (left) and Lucy Stent Repko '72 celebrated together when they both retired on June 10, 2007, after thirty-five years teaching Home Economics. Marie taught for the New castle (Pa.) Area School District and Lucy taught for the Poland (Ohio) School District.
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Joe Blanton taking injured elbow to Dr. James Andrews
May 23, 2011, 4:50 PM EDT
Scratched from his Thursday start and placed on the disabled list with the same elbow problems that shelved him earlier this season, Joe Blanton will now get a second opinion from Dr. James Andrews.
Meeting with Dr. Andrews is never a good thing for a pitcher and beyond that Matt Gelb of the Philadelphia Inquirer reports that "the Phillies are still unsure of the problems inside Blanton's right elbow" and "Blanton expressed some doubt as to what is going on in his elbow."
In other words no one knows what's going on, although at this point the decision to let Blanton pitch through elbow pain previously looks like a very questionable call for the pitcher and the team. In between the DL stints Blanton had a 5.50 ERA in six starts.
At the very least he figures to miss a few weeks and even if Dr. Andrews doesn't discover anything that requires surgery you can be sure the Phillies will be a lot more patient bringing Blanton back this time.
- halladaysbicepts - May 23, 2011 at 4:57 PM
There is a bright side to this. At least Fat Joe is taking his injured elbow to a doctor instead of the Colonel at KFC.
- purdueman - May 23, 2011 at 10:56 PM
Actually I heard that Fat Joe switched his allegiances to Popeye's Chicken because it has a lot more finger lickin' good grease on it!
- CJ - May 23, 2011 at 5:08 PM
take your time Joe, Worely's doing just fine. They sent him down to keep him stretched out for exactly this reason.
- xmatt0926x - May 23, 2011 at 6:09 PM
CJ you stole my thunder. I was thinking the exact same thing. Please Joe. Think of your future and DONT RUSH BACK. I'd say a good 6 months off is needed here. Thanks for your 2008 contribution Joe. See you at the 25th anniversary ceremony in 2033. Certainly not going to go down as one of Amaro's better signings. Ohh and Joe, you'll need some buds to hang out with for the next 6 months. If I was you I'd take Herndon, Baez, and Romero with you.
- bjavie - May 23, 2011 at 5:41 PM
This is two years in a row now. For a guy who was dubbed "durable" when they brought him in, nonetheless.
Any chance that last year he was trying to just keep up with Halladay and Hamels and he wore out? And now this year he this year he is trying to keep up with…well, Vance Worley???
Just quit making Halladay, Lee and Hamels throw 120 pitches and go 9 innings every game. That way you can go with a 4 man rotation and then everytime the bullpen comes in they don't look like they haven't pitched in two weeks.
- drunkenhooliganism - May 23, 2011 at 9:10 PM
When did he wear out last year? in the second half of the year he was 6-1 with a 3.48 ERA. In august and september he was 5-0 with a 3.0 ERA.
And he has been durable, he's pitched at least 175 innings for 6 straight years. There probably aren't a dozen pitchers in the majors that can beat that.
Just because he's not an ace, doesn't mean he's not useful.
- cup0pizza - May 23, 2011 at 9:51 PM
Blanton is garbage whether healthy or not. Sad to see him shelved.
- purdueman - May 23, 2011 at 10:32 PM
The most dreaded phrase in all of sport… "Son, you have an appointment tomorrow with Dr. Andrews in the afternoon. Here's your plane ticket and taxi cab money to/from his office once you land. Be on that plane!".
Amaro was a complete and total idiot not to have unloaded Blanton and his huge remaining contract (approximately $17M over this season and next), in spring training when he had the chance!
- macjacmccoy - May 24, 2011 at 2:24 PM
Especially since Oswalt isnt out. I understand why they did it last time Oswalt was in Arkansas and then on the DL the offense wasnt hitting the bullpen was down 3 people and Blanton was out. It shouldnt be a problem this time around.
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Kevin Ray Turner
Position: LB
Height: 6-2 Weight: 223 lbs.
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High School: Mission San Jose
College: Pacific (school history)
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text:
Sarah Bernhardt as Mélisande in 'La Princesse Lointaine'
1 portrait of Sarah Bernhardt
© National Portrait Gallery, London
Sarah Bernhardt as Mélisande in 'La Princesse Lointaine'
by Reutlinger
carbon print, published 1 June 1895
4 3/4 in. x 3 1/2 in. (121 mm x 90 mm) image size
Purchased, 1984
Photographs Collection
NPG Ax28880
Click on the links below to find out more:
Sitterback to top
- Sarah Henriette Rosine Bernhardt (1844-1923), Actress. Sitter associated with 36 portraits.
Artistback to top
- Reutlinger (active 1850s-1937), Photographers. Artist associated with 26 portraits.


text:
I'd hate to think that this mod has finally breathed its last. It holds so much potential.
"Take a look around you at the world we've come to know,
Does it seem to be much more than a crazy circus show?
But maybe from the madness something beautiful will grow,
In a brave new world,
With just a handful of men.
We'll start, we'll start all over again"
Early June 1888 -
Those dreadful pods landed on our island.
From that point on, our world, the course of human history, would be radically altered forever.
With our backs against the wall we had no choice but to change our plans and grudgingly admit that we, former masters of this planet Earth, had been replaced by a more dominant form of life.
With that realization we went down, deep into the Earth's crust, separating ourselves from the world above.
June 1928-
The horrors of the surface seem so distant now, but we all remember. It is a new world, a quiet and disciplined existence free of catastrophe but lacking in the carefree flow of lives we enjoyed in our youth.
Our children today have never known a blue sky or a sunset, nor the song of bird, the smell of fresh rain...
But the world awaits our return... And someday there will at last be a reckoning.
We have a plan.
War of the Worlds: Earth Under the Martians is an open world survival horror game in the very early stages of production.
Watch us for more info.
5 comments by squigcake on Oct 30th, 2011
Hello guys,
As our team grows and discussion of development continues more and more, questions arise. Even though we have not hit the full on development stage, we still need to be able to plan out certain aspects of the game.
We are looking for new people to join the mod team who are willing to discuss the early game mechanics and help us finish the rest of the design process.
We need mostly, at this point, a sound engineer. Our Musical Composer, Anton Riehl, and I have been arranging our ideas and concerns about the implementation of music and dynamic ambiance into the Unreal 3 engine. Certain questions arose that would need to be addressed by a sound engineer in order to utilize both the music and overall design of the project.
If anyone is interested in helping with this blueprint we would be more than happy to have you on with us.
We are also looking for people experienced in:
- Programming (Preference for UT3 Experience)
- 3d Modeling/Animation
- Level/Map Design
- Texture Art
- Concept Art
These people will be key in planning out the early phases of development as well as in putting together the actual game.
I'd hate to think that this mod has finally breathed its last. It holds so much potential.
I am a 3D modeler myself if i can help in anyway, then i'm glad to be of service if not then no harm done.:D
Well that's very good to hear, cant wait to see those fighting machines in action :)
Curious to know about the gameplay for this mod. Will it be linear in level design or a bit more free roaming? Just eager to see this actually get into level development :)
Free roam for sure. Think Day Z with Tripods, but more unpredictable and dynamic.
Just another follower saying "I hope something great comes of this!"
As long as you have some true-to-the-era British content I will be pleased!
Update yeah, where have been then! To Mars and back?
We were busy building a brave new world.
Promote War of the Worlds: Earth Under the Martians on your homepage or blog by selecting a button and using the embed code provided (more).


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Carman DM
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Lee and I were both born in Nebraska and we enjoy the search for family history. Bennett, Wolverton, Train, Tracewell, Matson, Coles, Power, Bebb, Merritt, Rogers, Workman, & Matthias Miller are a few of the family names we research.
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Lila Cole
Marie Frost Wiegel
Thank you SO much for the info from the obit that lead to us finding her maiden name, and thus her marriage record and more! These are my cousin's people, but I enjoy helping anyone out who might be looking for their family with the help of findagrave, even if they are not related. Letters like yours are one of the things that make my research worthwhile and rewarding!
Added by
Lila Cole
on Jun 14, 2015 10:11 AM
Dennis Harmsen
Note 3
Would you also move the gravestone up for Carl Gill please, 25057947, thanks.
Added by
Dennis Harmsen
on May 19, 2015 8:51 AM
Dennis Harmsen
Note 2
Carman: Would you also move the gravestone photo for Hilda Gill, 91413898, to the top? Also, Donald Gill is at 91526276. Thanks.
Added by
Dennis Harmsen
on May 19, 2015 8:47 AM
Dennis Harmsen
Hi Carman! Would you mind moving the gravestone photo for Donald Gill up to the top above the posted obit? Thanks.
Added by
Dennis Harmsen
on May 19, 2015 8:41 AM
Donna Cullins Schroeder
Charles Booe
Have been going through several sets of records for Mt. Zion Cemetery because there was a workshop on stone restoration there today. I saw that you added Charles to the find a grave records. Would like to document how you know he's buried there and if there are any other family members buried there, as well as any history you have on him. There are a several members of a Booe family buried in our City Cemetery. I have no connection to family, but would like to add him to the list we keep in the library and at the museum. Thanks. Donna
Added by
Donna Cullins Schroeder
on May 09, 2015 3:34 PM
T Boss
Christian Boss
Hi! I am working on my family history and Christian Boss is my great great grandfather. I have linked him to his son John. I don't know if you are a relation to Christian or just entered information from Gruetli Cemetery. If not a relation would you mind transferring Christian to me? Memorial 16590978
Added by
T Boss
on Apr 22, 2015 1:49 PM
Myrtle Clara Jewell Everts
I have read Myrtle's obituary.
I have researched her and have found no record in the sextons Waco cemetery book. I too feel she is buried here in the Waco cemetery. It seems her name was overlooked when it came time to enter it in the record's. I'm wondering are you a close relative and or maybe know someone who mite have the cemetery deed or any information? The cemetery board is trying to locate the unmarked graves and identify them. You mite have noticed that there are no plot location associated with Myrtles memorial. I have entered most of the cemetery here, with grave location and have contacted those who have placed memorial's here.
Sure would like to hear from you and any info you mite have.
Added by
on Apr 13, 2015 5:55 AM
R Z Rema
Mary Rema
Hi Carmen,
Mary Josephine (Mannon) Rema was my great grandmother.
What a thrill to see her tombstone, even though it is damaged.
There are other children of hers we can add, I'll see if I can manage that. Thank you for posting the info you did, I appreciate your efforts.
Added by
R Z Rema
on Apr 12, 2015 9:27 AM
RE: Kinney
Hi Carmen, next to mr Orville was Clarice and Donald Kinney I added memorials and photos assuming they were all related. Also there was a stone for Donna with no death date. Hopefully this is helpful to your search
Many thanks--@ngel
Added by
on Apr 07, 2015 4:45 PM
Beth Parker
Your request
Myrtle J (Parish) Hinds Merida was my great grandmother. Chester was her 2nd husband, so my relation with him is only by marriage. Myrtle's first husband is my great grandfather.
Added by
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on Apr 02, 2015 10:33 AM
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Winnebago is the leading incorporation in manufacturing motor homes and related products. Motor homes are a type of recreational vehicles
which are popular in the country. Based in Forest City, Iowa, the company was formed in the year 1958. With
the economic meltdown, the community people sought the help of a California company to start a travel trailer factory in the area. With the efforts of John K. Hanson, the company started its operations and was named Winnebago Industries in 1960. The company started manufacturing furniture and other components for travel trailers. Thermo-Panel registered trademark innovation of Winnebago helped it produce lightweight yet strong sidewalls in 1963. Then the first motor home was released in the year 1966. Winnebago introduced its first assembly line and other innovations in motor home manufacturing. This innovation helped them compete and the brand was able to produce vehicles at
a lower price. During the 1970s the company expanded and it was listed in the New York stock exchange. In 1975
the Itasca line was introduced and was well received in the market. Winnebago also introduced
the Era models which were also a grand success. With more than 50 years of experience, the brand
has always been committed to providing high-quality and stylish motor homes.
If you are looking for Winnebago parts then you can find them in our online catalog. We have a wide range of Winnebago motor home parts that are affordable and are available at wholesale pricing. The parts are tested to meet the industry standards and come with warranties. You can also call and speak to our experts in our toll free 1-800-565-5021
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These pages provide an overview of domestic violence and sexual assault as well as more detailed information about specific forms of abuse.
Checklist to help you identify red flags of abuse.
Overview of domestic violence, who it affects, and the different types of abuse.
Information on emotional and psychological abuse.
Information about sexual assault and rape.
Information about rape by a spouse or intimate partner.
Information about domestic violence in the LGBTQ community.
Information about stalking and harassment, including cyberstalking.
Information about credit card debt, identity theft and other money matters when there is domestic violence.
Teen dating violence and sexual assault
All of the legal information on this website applies equally to men as to women.


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Environment: Sector Results Profile
Bank Group ContributionOver the past decade, the Bank (IBRD/IDA) committed funding for US$33 billion, from which IDA's contribution was US$7.7 billion (23 percent) to support investment in environment... Show More +
Oceans: Sector Results Profile
Bank Group ContributionThe World Bank and Bank-managed trust funds are increasingly supporting initiatives to rebuild the ocean's natural capital. Many of the Bank's investments in the oceans over the... Show More +
Information and Communication Technologies: Results Profile
Afghanistan: A US$22 million IDA credit supported sector reform that made the telecommunications market more competitive. The project has attracted over US$2 billion in private investments, impro... Show More +
Graduation Program: Creating Pathways out of Extreme Poverty into Sustainable Livelihoods
BeneficiariesAchiron Bibi joined the Graduation Program in West Bengal. She wanted to build a fish pond, start a vegetable garden, and expand her bangle business. This would allow her to send all five... Show More +


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A Morning Jog— Jogging is so much better with a remote controlled sex toy.
48 Hours on Blue Bayou Pt. 07: Julie— First service.
A Monster Unleashed Ch. 03— A BDSM Journey.
A New Pet Ch. 02— A new pet is tested.
A Taste of Domination— Is she strong enough to be a slave?
A Sub's Very Special Wake Up Call— My inexhaustible Master wakes me up.
A Sub's Treat— A good little pet gets her reward.
A Night on the Town— Master takes his pet out for the evening.
9 Hours Late— A sub arrives home 9 hours after she was meant to.
A Play Session— A sub has playtime with her Sir.
A Different Punishment— Pet is in for a different kind of punishment.
A Slut, a Vibrator, and a Ball Gag— A light bondage coupling.
A Journey Begun— The diary entries of a submissive female.
A Sexy Office Visit— A deprived sub visits her loving Master at his job.
21st Century Slave Ch. 02— Wife is sentenced to hard labor and is loving it.
A Promise To Be Kept— New submissive gets to play with electricity.
A Kitten Tail— Kitten gets a present from Sir and Mistress.
A Surprise for Sir— Wet Panty Fantasy.
A Night to Remember— A girl submits for the first time.
A Slut And Her Toys— One naughty night of play.
A New Leaf— Two lovers move into bondage.
A Couple of Bunnies— Master gets two bunnies to play with.
A Friday Night— A submissive puts on a show.
A Night of Frustration— You submit to your brutal master's will.
A Dangerous Game Ch. 02— Austin and Steph continue the games.
A New Game— A good spanking and anal leave her moaning and sore.
A D/s Love Story— A Master and his sub find each other. They become one.
A Little Sex Story— A moment with his slut.
A Good Bitch— She tries to be a good bitch for you, her master.
A Juicy Story— She entertains her lord and master while hubby is at work.
A Task For Kitten Ch. 01— Master chooses the task of seduction for His kitten.
A Pony Sundae— Master turns pony into a Sundae treat.
A Boss, A Mentor, A Lover Ch. 04— She becomes his willing slave, submissive yet proud.
A Dinner Party— A discovery and a new Master.
A Precious Gift— He gives her a precious gift.
2 Weeks Off— His holiday in the mountains leads to her submission.
A Gentle Seduction— Old friend visits and resumes domination.
A Submissive's Punishment— Your displeasure in your sub.
A Perfect Evening Ch. 02— Dom - sub interaction from his point of view
A Perfect Evening Ch. 01— Dom - sub interaction from his point of view.
A Teacher's Way Out of a Dilemma Ch. 07— Kevin prepares Pam to become his sub.
A Morning's Service Ch. 01— A new Dom comes visiting.
A Sexy Scene— Just you, me and our bodies.
A Gift for a Friend— An unsuspecting girlfriend is tied up and left as a present.
A Girl Like Me— He's waiting for you....
A Rose By Another Name— A slave gets punished.
A New Life for Debbie Ch. 04— Drum transportation.
A New Life for Debbie Ch. 03— Debbie's initial training is continued.
A Summer Day— She goes to his home.
A Restrained Night Out— You takes your slave out for an evening.
A Letter to my Master— Crossdressing is fun for my new master.
A Good Night's Dream— She has a very life like dream late Friday nite.
A Dom to Call Her Own— She finally gets what she wants with a coworker.
A Sub's First Night With Her Dom— Sub experiences her first night of loving pain with her Dom
A Night With Master— Master and slave enjoy one another.
A Day In A Slave's Life Ch. 01— Master - slave interactions.
A Spanking Romance— He shows his love with domestic discipline.
A Dominant's Trip— He decides to meet you, His online submissive
A Letter to Explain...— A submissive explains her devotion to her Master
A Surprise for a Slave— A generous Master gives his slave the ultimate gift.
A Submissive Spanked Girl— A younger man and an older woman meet.
A Quiet Day at the Office Ch. 02— You discover your true nature.
A Rise to Dominance Ch. 02— My dominant side grows, with help from Kelly.
A Little Understanding— You're not hurting to be understood
A Day At The Park— When wishes are not all they seem.
A Night On Her Knees— A submissive on her knees ready to please.
A Horrible Diagnosis Spawns Adventures Ch. 03— Mary discovers her submissive nature.
A Day in the Life of Lexy Ch. 03— Lexy learns a new skill, but will she deny her Master?
A Sexy Class Reunion— 25 years later a guy and girl get it on.
A First Meeting— A sub's coice for their first meeting, or is it?
A Long Massage— A sub romances her master.
A Gift— A story about a sub and her master.
A Night in the Boondocks— She has a debt to pay to Him.
A Nice Birthday Present— Katie gives a friend the birthday present of a lifetime.
A Slave's Gift— Aisha finally learns her slavery to her Master.
A Story for Betty— Betty and Jake meet for dinner, discussion, and maybe more.
A Quick & Dirty Reunion— She goes searching for her silver fox.
A Date With Sir— A meeting with her sir four years after the fact.
A Domme and Her Lord Ch. 03— Punishment finished and Pleasure given.
365 Days of Master Ch. 03— Training A 'tite chatte: Day Three.
A Camping Trip to Remember— He takes control on a camping trip.
A Day in the Life of a Good Girl— There is no average day in the life of a 24/7 slave.
A Submissive's Journey Ch. 01— Floating.
A Gift of a Corset— BBW goth is corseted and dominated by her lover.
A Question of Semantics— College professors debate the meaning of dominance.
A Day in the Life...— Horny couple buying a car gets the salesman involved.
A Diversion from the Game— Your sub gives you a diversion from his afternoon of games.
A Night to Remember— Dreams do come true.
A Day in the Life Ch. 01— Sofia's day as Master's property.
A Dark Winter Storm Ch. 02— Her Boss takes her to the next level.
A Lifetime of Training— His wife finds her true self.
A Slave's Story— A young woman becomes a slave.
A Master's Story— An older man becomes a Master by accident.
A Kiss at the End of Our Day— Dominant man & submissive woman come together.
A Fantasy Come True Ch. 01— Joe dominates his wife & another woman.
A Story of Jane Ch. 03— Do ravishment fantasies come true?
A Bit More Fun— He leaves her tied while he hosts a seminar.
A Good Slave is Like a Fine Car— A romantic comparison.
A Master's Ring: Book 03— The Brotherhood invades every part of David's life.
A Master's Ring: Book 01— A secret Brotherhood asks David to join their ranks.
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The 5th-seed Anoka Bucs swept 12th-seed Rum River to win the best-of-three series and advance in the Region 1C amateur baseball playoffs. On Friday night, host Anoka prevailed 10-0 in 7 innings, then the Bucs won in Cambridge 11-0 on Sunday afternoon. Along with Anoka, Princeton and Hinckley won the...Read More
The Rum River amateur baseball squad takes on host Anoka Friday, July 29 (7:30 p.m.) in the opening game of the best-of-three series in the Region 1C tournament. That game will be held at Castle Field in Anoka. The 12th-seed Bandits (1-23) will then host the No. 5 seed Bucs (19-12) at 1 p.m. Sunday,...Read More
After defeating Coon Rapids in the District 10 tourney opener, the Cambridge Legion wrapped up its baseball season with losses to Eden Prairie (17-5) and Osseo (11-4) over the next two days last weekend. The Post #290 team finished the season with a 14-8 record. Eden Prairie 17, Cambridge 5 Playing ...Read More
Isanti remained undefeated in Eastern Minny action with a 7-3 victory over Hinckley on July 15. Joe Ramberg threw nine strong innings, racking up 9 strikeouts while allowing 7 hits against the Knights. Packy Lind led the offense with a 4-for-5 night, stroking 2 doubles and gathering 4 RBI. D.J. Lind...Read More
The Cambridge Legion's second-round playoff game against Hinckley was postponed due to rain from July 14 to Friday, July 15, 5:30 p.m. at Princeton. The winner stays alive to play the loser of Thursday's Chisago Lakes vs. North Branch game, with that game taking place 8 p.m. Friday night...Read More
Report from Post #290 Coach Wade Reichmann: After leading most of the game, the Cambridge Legion dropped its first round playoff game 8-7 to St Francis on two unearned runs in the eighth. Pitching and hitting were strong enough to win the game, however the defense committed six physical errors along...Read More
AREA BASEBALL UPDATES The Isanti Redbirds will once again host the Eastern Minny League All-Star Game at Redbird Field, with the fun day coming Sunday, July 17. Action gets underway with a 3:00 p.m. – Home Run Derby at 3 p.m., a 4:00 p.m. – Pulled Pork Dinner at 4 p.m. ($5/plate) and the A...Read More
The CICB 13-U AA baseball team qualified for the USSSA World Series event being held in Canton, MI the week of July 23-30. The boys had a great season finishing 1st in their MYAS division with a 12-4 record along with an 8-3 tournament record. Fundraising is underway to pay for the trip to Michigan;...Read More


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Whole fresh sea bass served with potatoes, olives and tomato. Perfect straightforward seafood. I wish this family restaurant was around the corner from home.
We go here often and we're never disappointed. The food is good and the portions are generous, the service is good, the setting is good. Good food and good service - what else do you need if you're eating out? Oh and the wine's ok too!
Bar and restaurant are superb for food and sightseen. Service it is quite slow but in the nature of the slow life style of the place. So if you are on holiday take your time and sit back.
We come to Italy every year and we frequent Vela! Wonderful service, great food, and fantastic view!
We are for Hawaii and very critical of seafood because we have such an abundance at home. The food at Vela is fresh and amazing!
They are also kid friendly as we bring both our kids and have them going in and out...
Been here year after year in early June. Superb seafood lunch and beach combination - can't beat their orecchiette anywhere else.
I dream of this place when I'm enduring another Norfolk winter. It's just perfect for a beach lunch in high summer. Quite a relaxed and (I like to think) glam crowd. All good on the menu, highlights being the fish of the day. House wine and a snooze under the umbrelloni on the beach. Aaaah I'm back on holiday...!
Stumbled upon this place many years ago and have come back every year since for the spaghetti vongole and calamari friti. Always a great meal. Book ahead to get a seat outside. Closed December - end of February. 0734.676482
This beach is perfectly kept but a man that looks something like Phil Collins!! Seriously though, the beach is lovely and the restaurant attached is superb. Excellent orechiette alle vongole. There is something magical about swimming in the morning and strolling up to eat an amazing lunch. Unforgettable!
Had a great lunch here today in late September sunshine and 28c looking out at an empty beach with most of the chalets closed for the season - we were so glad that the Vela stays open until November. We had the antipasti freddo and salmon carpaccio to start, both delicious with the antipasti plate a real joy - the...
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Armando Vazquez-Ramos, M.A.
California State University, Long Beach
Chicano & Latino Studies Dept.
1250 Bellflower Blvd.
Long Beach, CA 90840-1004
Tel. (562) 985-2847
Fax (562) 985-4631
E-Mail: email@example.com
Web: California-Mexico Studies Center, Inc.
Web: Mexican Cultural Institute, Los Angeles
Read about Profe Armando Vazquez' latest projects:
CMSC Seminar Program (March 24, 2015)
14 Dreamers to Take Historic Spring Break, Inside CSULB, March 16, 2015
TIME TO INTRODUCE ETHNIC STUDIES INTO THE LBUSD CURRICULUM, Voice waves Long Beach ~ March 18, 2015
Professor Armando Vazquez-Ramos is Board President of the Mexican Cultural Institute of Los Angeles, and Co-Chair of "Amigos de Siqueiros", the non-profit that will operate the City of L.A.'s $8 million "America Tropical" Interpretive Center of Maestro David Alfaro Siqueiros 1932 mural at the city's birthplace on Olvera Street.
Since January of 1968, Professor Vazquez-Ramos has been an activist in the educational, cultural and political circles of L.A.'s Chicano/Latino community, and currently teaches on Chicano/Latino education, history, politics, public policy, and US-Mexico relations at the CSU Long Beach Chicano and Latino Studies Department, where he is also Coordinator of the California-Mexico Project and established the Latino Political Roast to raise scholarship funds for a major study-abroad program.
Through a bi-national network of political, educational and community leaders, he has helped to promote the revamping of relations between California and Mexico, faculty and student exchange programs, the presence of Mexican universities in the U.S., and to foster the Sister City relationship between Los Angeles and Mexico City.
In addition, Professor Vazquez-Ramos has been an outspoken advocate for voting rights of Mexicans in the U.S. and is affiliated with the Coalition for Political Rights of Mexicans Abroad (CDPME) that succeeded in gaining approval for the right to vote by Mexicans residing in the U.S. in 2006.
As a student leader at CSULB in 1969, Professor Vazquez-Ramos was a co-founder of the Chicano and Latino Studies department, where he earned a B.A. in Mexican-American Studies and a Master's in Psychology. He has also earned a Master's in Public Administration at Pepperdine University and is currently working on his doctoral dissertation on "A Development Plan for Mexican Universities in the U.S." and a book on the Mexican community of Long Beach, California, where he was co-founder and Director of the L.B. Centro de la Raza and Escuela de la Raza for almost 20 years in the 1970's and 1980's.


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Hi! I am Ana Iris Valenzuela, a student from Environmental Charter High School. I'm
a student producer for KCET Departures Richland Farms. yep...
this is my first time participating in a film production [and hopefully not my last one]. So.....
yep....oh i remember now. what you are about to see will show you a little about me. i hope [really hope] you like it. Oh and thanks 4 watching it. ...........[lol i love writing like this].
- A Los Angeles Primer
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Ok, so the ghetto biker is starting to spend money. I bought a set of padded lycra shorts and they are nice, but the padding and i disagree sometimes. I must admit that the post about them helped the purchase, and I'm getting used to them. But what i really want to know is what you got under them shorts? I'm a boxers man, but the seem in my boxers has got to go. I'm thinking about trying a hybrid or even breifs.
Some may call me a pervert... and there is not much i can do to disagree with that because well.. i do want to know.
call me sick..


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McDonald's is now serving espresso in Starbucks' home Seattle market and has billboards there with pointed messages, such as: "Four bucks is dumb." The point, of course, is that what folks pay for some espresso or latte drinks at Starbucks. A small McDonald's latte is about $1.99.
It's a "lighthearted" local promotion that reflects McDonald's "fun approach to our brand," McDonald's spokeswoman Danya Proud says.
But Starbucks isn't biting — and it won't respond to the ads, spokeswoman Deb Trevino says. Yet, she does point out that some of the java giant's drinks are similarly priced to McDonald's.
For instance, a cup of brewed coffee costs about the same at Starbucks and McDonald's in the Seattle market.
"For us, the bottom line is not price," Trevino says. "Customers come to us for the experience."
P&G ad spending shrinks
Procter & Gamble, the biggest U.S. advertiser, has serious plans to cut global marketing costs in 2009. The sour economy and unstable media environment offer opportunities for companies to re-evaluate ad spending, P&G CEO A.G. Lafley said at an analyst conference last week. "Because we're the biggest advertiser in a lot of these countries," he says, "we just go in and tear up the contract."
P&G already did major slicing in 2008, according to new TNS Media Intelligence data. It spent $2.3 billion on media in the first nine months of the year, a 5.9% drop vs. a year ago.
Overall ad spending for January through September fell 1.7%, with auto, telecom and retail marketers all slashing outlays. For a look at advertising spending trends in the top 10 categories, see the above chart.
Pepsi glass is half-full
Pepsi-Cola's new marketing will play up optimism. Research found that target buyers — so-called Millennials born 1980 to 1990 — are "confident" about 2009, and 95% agree it's important "to maintain a positive outlook on life."
A redesigned logo on cans showing up in stores now looks like a smile. Ads from TBWA/Chiat/Day Los Angeles, which unseated BBDO New York as Pepsi's agency, may begin in January. Pepsi also will be a big player in February's Super Bowl, where it paid a premium to keep rival Coca-Cola ads out of the first half.
Drugmakers prescribe ad rules
The catchphrase, "I'm not a doctor, but I play one on TV," may soon show up in prescription drug ads. Among tightened voluntary guidelines unveiled by drugmakers last week is one calling for ads that star actors "in the roles of health care professionals" to disclose the folks are actors.
Other Pharmaceutical Research and Manufacturers of America (PhRMA) ad rule revisions:
• Be sure celebrity endorsers support the drug.
• Disclose whether health care pros in ads got something of value to pitch the drug.
• Put ads "inappropriate" for kids in media where 90% of the audience is age 18 or older.
Doesn't take the cake
Fruitcake just can't get respect. The much-mocked dessert ranked last in an NPD online survey of holiday snacking plans: Just 11% of 3,600 adults surveyed expect to eat any over the holidays, even behind trail mix (12%). "Do you really need to ask why fruitcake is at the very bottom of the barrel?" NPD spokeswoman Kim McLynn says.
Atop NPD's holiday snack list was cookies, at 65%, but No. 2 was a shock. Vegetables edged No. 3 chocolate in expected holiday snacking.
But the Ad Team strongly discourages putting out veggies for St. Nick. He's a cookietarian.
Making the holiday circuit


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Book Search
China's Legal Reforms and Their Political Limits
Presents new insights into recent changes in China's legal framework in areas crucial to the modernisation process. Topics include law reform to accommodate foreign interests and convert China to a market economy, the judicial system and its treatment of human rights issues, the introduction of...
Published April 10th 2015 by Routledge
Rural Development in Transitional China
The New Agriculture
Since the late 1970s, China has experienced the most rapid social and economic changes in world history. Over 200 million rural inhabitants were lifted out of absolute poverty and tens of millions became wealthier than the average urban resident.This book offers an authoritative and in-depth...
Published February 5th 2004 by Routledge
Cooperative and Collective in China's Rural Development: Between State and Private Interests
Between State and Private Interests
Following China's successful decollectivization, diverse new organizational forms arose in response to different local situations. The contributors dissect the relationships among the emerging class of entrepreneurs, local officials, and their family members and associates....
Published September 30th 1997 by Routledge


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RFK Stadium will be the host for the 2015 Military Bowl Presented by Northrop Grumman and tickets are going to be in high demand in Washington. The Military Bowl goes down on December 28, 2015 in Washington, with a 4:30 p.m. kickoff time. Being played since 2008, the Military Bowl has become a football tradition few can match. Surely the fact that its played at RFK Stadium in Washington DC has played a part. In the past it has also been called the EagleBank Bowl and the Congressional Bowl. If you can get your hands on Military Bowl Game tickets for the big match at the RFK Stadium, then TL is the right place. As far as RFK Stadium tickets go, the Military Bowl is one of the most anticipated. Be there for the Military Bowl Presented by Northrop Grumman at RFK Stadium in Washington and see some great football live and in person.
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Home / Store / Journals / Electronic Articles / Fusion Science and Technology / Volume 7 / Number 3
Scipione Bobbio, Enzo Coccorese, Giulio Fabricatore, Raffaele Martone, Guglielmo Rubinacci
Fusion Science and Technology
Volume 7 / Number 3 / May 1985 / Pages 345-360
Format:electronic copy (download)
In the international tokamak reactor (INTOR), the problem of the passive control of the vertical instability is to be solved by means of suitably shaped saddle coils to be embedded in the blanket structure. The efficiency of such a system depends on the characteristics of the passive conductors and on the plasma equilibrium as well as on the type of plasma displacement assumed. To cover the physical uncertainties caused by the model assumptions for the plasma with respect to the motion on a slow time scale (of the order of several tens of milliseconds) corresponding to efficient passive stabilization, four different plasma displacement models are considered and compared with each other. A stability analysis is performed using the energy principle, expressed in circuital form. The results of the INTOR analysis are presented and discussed, showing in particular that under very general conditions the optimum stabilization efficiency is obtained for passive conductors situated at ∼60 deg above and below the horizontal midplane at the outboard side. The effect of the geometric parameters of the saddle coils (e.g., area and shape of the cross section, toroidal segmentation, etc.) on the stabilization efficiency is investigated; a parametric study of these dependences is presented. General conclusions applicable to INTOR are drawn.
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Performance golf ball fitting focuses on finding the best ball for your game and lowering your score.
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August 30th, 2013:It was a beautiful morning and prior to starting our round, I had given a member of our foursome an inexpensive pull cart because he did not have one. On the
In my 21 years in my golf league, there were only two hole in one's before mine, which occurred at about 6:00 PM EDST on August 14th, 2013. I used a Titleist Pro V1 and my 4
It was a beautiful 5 iron the never left the flag on the 187 yard 8th hole at Cobbs Creek. It disappeared at the flag and we were not sure if it went in or went over the green
The hole was 138 yard par 3. We had a head win in our face about 15-20. I jumpeded three clubs and played it back and layed off it. The best shot I have ever hit and it hit 6
Was playing at the OAKS Country Club in Tulsa Okla. on Thursday August 29,2013. On number 6, playing 156 yards using a nine iron and a Pro V1x. The ball went straight in the


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Home » Tools for Writers » Conferences & Residencies » Aspen Summer Words
The 39th annual Aspen Summer Words Writing Retreat and Literary Festival will be held from June 21 to June 26 at the Gant Hotel in Aspen, Colorado. The retreat offers workshops, panels, and readings in fiction and creative nonfiction, as well as opportunities to meet with agents and editors. The faculty includes fiction writers Ann Hood, Richard Russo, Akhil Sharma, and Hannah Tinti; and nonfiction writers Andre Dubus III and Dani Shapiro. The festival features lectures, readings, panel discussions, and the opportunity to meet with agents and editors. Tuition for the retreat ranges from $1,100 to $1,375, which includes some meals. A limited number of scholarships are available. To apply for a workshop in fiction, novel editing, or memoir, submit up to 10 pages of prose with a $30 application fee by February 27. Registration for a beginning fiction workshop is first come, first served. Tickets to the festival are $150, or $20 for individual readings. Call, e-mail, or visit the website for an application and complete guidelines.
Aspen Summer Words, 110 East Hallam Street, Suite 116, Aspen, CO 81611. (970) 925-3122. Caroline Tory, Program Coordinator.