text:
Research Topics
Genomes and Genes
Gene Symbol: HNF1B
Description: HNF1 homeobox B
Alias: FJHN, HNF-1-beta, HNF-1B, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF-2, TCF2, VHNF1, HNF1 beta A, hepatocyte nuclear factor 1-beta, homeoprotein LFB3, transcription factor 2, hepatic
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications189 found, 100 shown here
- Enlarged nephrons and severe nondiabetic nephropathy in hepatocyte nuclear factor-1beta (HNF-1beta) mutation carriersJørn V Sagen
Department of Pediatrics, Center for Genetics and Molecular Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway
Kidney Int 64:793-800. 2003..lead to a syndrome with diabetes and urogenital malformations [maturity onset of diabetes of the young, type 5 (MODY5)]...
- Spatial and temporal expression of the myometrial mitogen-activated protein kinases p38 and ERK1/2 in the human uterus during pregnancy and laborHarry A Otun
School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
J Soc Gynecol Investig 12:185-90. 2005....
- Mapping of a new candidate locus for uromodulin-associated kidney disease (UAKD) to chromosome 1q41Katerina Hodanova
Center for Applied Genomics, Institute for Inherited Metabolic Disorders, Charles University 1st School of Medicine, Prague, Czech Republic
Kidney Int 68:1472-82. 2005..and progressive renal insufficiency are features associated with familial juvenile hyperuricemic nephropathy (FJHN), medullary cystic kidney disease type 1 (MCKD1) and type 2 (MCKD2). MCKD1 has been mapped to chromosome 1q21...
- Multiple newly identified loci associated with prostate cancer susceptibilityRosalind A Eeles
The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
Nat Genet 40:316-21. 2008..7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3...
- Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinomaAkira Tsuchiya
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
Am J Pathol 163:2503-12. 2003..Our results suggest that HNF-1 beta is not only an excellent CCC-specific molecular marker but also a molecular target for therapy of ovarian CCC...
- Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studiesKatherine S Elliott
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS ONE 5:e10858. 2010Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk...
- Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal diseaseEmma L Edghill
1Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
Nephrol Dial Transplant 23:627-35. 2008..HNF-1beta gene deletions have recently been shown to cause renal malformations and early-onset diabetes...
- Gene expression profiling predicts clinical outcome of prostate cancerGennadi V Glinsky
Sidney Kimmel Cancer Center, San Diego, California 92121, USA
J Clin Invest 113:913-23. 2004....
- Transcription factor HNF1beta and novel partners affect nephrogenesisKarin Dudziak
Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
Kidney Int 74:210-7. 2008..Because of these renal anomalies, HNF1beta is classified as a CAKUT (congenital anomalies of the kidney and urinary tract) gene...
- Genome-wide association study identifies a common variant associated with risk of endometrial cancerAmanda B Spurdle
Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 43:451-4. 2011..We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7...
- HNF1B mutations associate with hypomagnesemia and renal magnesium wastingShazia Adalat
Nephrology Unit, Great Ormond Street Hospital NHS Trust, London WCIN 3JH, UK
J Am Soc Nephrol 20:1123-31. 2009Mutations in hepatocyte nuclear factor 1B (HNF1B), which is a transcription factor expressed in tissues including renal epithelia, associate with abnormal renal development...
- Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1Alexander J Michels
Linus Pauling Institute and the Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
Am J Physiol Cell Physiol 297:C1220-7. 2009..Together, these data suggest that HNF-1alpha and/or HNF-1beta binding is required for SVCT1 expression and may be involved in the coordinate regulation of whole body vitamin C status...
- Renal cysts and diabetes syndrome linked to mutations of the hepatocyte nuclear factor-1 beta gene: description of a new family with associated liver involvementAlberto Montoli
Renal Unit, Niguarda Ca Granda Hospital, Milan, Italy
Am J Kidney Dis 40:397-402. 2002Mutations in the hepatocyte nuclear factor (HNF)-1beta gene (TCF2) are responsible for a syndrome characterized by maturity-onset diabetes of the young, a nondiabetic renal disease, genital malformations, and liver dysfunction.
- Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylationLi Jin
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Pharmacol Exp Ther 340:648-55. 2012....
- Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesisFadi Brimo
Department of Pathology, Johns Hopkins Hospital Medical Institutions, Baltimore, MD 21287, USA
Hum Pathol 42:1613-9. 2011....
- Hepatocyte nuclear factor-1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF-1beta in human pancreatic developmentE L Edghill
Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
Diabet Med 23:1301-6. 2006..We aimed to investigate the role of HNF-1beta mutations in neonatal diabetes and also the impact of HNF-1beta mutations on fetal growth...
- Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12Jielin Sun
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Nat Genet 40:1153-5. 2008We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci ..
- Association analysis of type 2 diabetes Loci in type 1 diabetesHui Qi Qu
Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
Diabetes 57:1983-6. 2008To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L.
- Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese populationCongrong Wang
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
Diabetes 58:1023-7. 2009Hepatocyte nuclear factor 1beta (HNF1beta) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis...
- Cell-specific involvement of HNF-1beta in alpha(1)-antitrypsin gene expression in human respiratory epithelial cellsChaobin Hu
Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Physiol Lung Cell Mol Physiol 282:L757-65. 2002..These results indicate the unique involvement of HNF-1beta in alpha(1)-AT gene expression in a cell line and primary cultures derived from human respiratory epithelium...
- Regulation of HSulf-1 expression by variant hepatic nuclear factor 1 in ovarian cancerPeng Liu
Departments of Experimental Pathology, University of British Columbia, Vancouver, British Columbia, Canada
Cancer Res 69:4843-50. 2009..Here, we show that variant hepatic nuclear factor 1 (vHNF1), encoded by transcription factor 2 gene (TCF2, HNF1beta), negatively regulates HSulf-1 expression in ovarian cancer...
- Multiple loci identified in a genome-wide association study of prostate cancerGilles Thomas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Nat Genet 40:310-5. 2008..the combined joint analysis, we confirmed three previously reported loci (two independent SNPs at 8q24 and one in HNF1B (formerly known as TCF2 on 17q); P < 10(-10))...
- Clinical spectrum associated with hepatocyte nuclear factor-1beta mutationsChristine Bellanne-Chantelot
Fédération des Services de Biochimie, Laboratoire de Biologie Moleculaire, Hopital Saint Antoine, Paris, France
Ann Intern Med 140:510-7. 2004Maturity-onset diabetes of the young type 5 (MODY5), a type of dominantly inherited diabetes mellitus and nephropathy, has been associated with mutations of the hepatocyte nuclear factor-1beta (HNF-1beta) gene, mostly generating ..
- Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutationsEwan R Pearson
Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UK
Diabetes Care 27:1102-7. 2004..However, physiological assessment of the HNF-1beta phenotype is limited. We aimed to test the hypothesis that the diabetes phenotype due to HNF-1beta mutations is similar to that in HNF-1alpha...
- Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetesWendy Winckler
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Diabetes 56:685-93. 2007..Specifically, we determined patterns of common sequence variation in the genes encoding Gck, Ipf1, Tcf2, and NeuroD1 (MODY2 and MODY4-MODY6, respectively), selected a comprehensive set of 107 tag single nucleotide ..
- Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetesJohan Holmkvist
Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
Diabetes 57:1738-44. 2008....
- HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitroD B Mendel
Beckman Center for Molecular and Genetic Medicine, Howard Hughes Medical Institute, Stanford University Medical School, California 94305
Genes Dev 5:1042-56. 1991..These studies define a pair of homeo domain proteins that have the potential to interact to produce an embryologically complex pattern of gene expression...
- More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processingI Bach
Unite des Virus Oncogenes, UA 1644 du CNRS, Departement des Biotechnologies, Institut Pasteur, Paris, France
EMBO J 12:4229-42. 1993..of cDNAs from human liver encoding several isoforms of the hepatocyte nuclear factor homeoproteins HNF1 and vHNF1 generated by the differential use of polyadenylation sites and by alternative splicing...
- Scanning for MODY5 gene mutations in Chinese early onset or multiple affected diabetes pedigreesC Wang
Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai No 6 People s Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China
Acta Diabetol 41:137-45. 2004..of HNF-1beta gene has been reported in early onset diabetes or MODY families and this gene has been defined as MODY5 gene...
- Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODYY Horikawa
Nat Genet 17:384-5. 1997
- Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetesJulius Gudmundsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:977-83. 2007..One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5...
- Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 betaC Bingham
Department of Vascular Medicine and Diabetes Research, School of Postgraduate Medicine and Health Sciences, University of Exeter, England, United Kingdom
Kidney Int 57:898-907. 2000..HNF-1 beta gene mutations are associated with a unique disorder characterized by maturity-onset diabetes of the young (MODY) and early-onset and progressive nondiabetic renal dysfunction, which may lead to chronic renal failure...
- pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) sR J Lee
Departments of Developmental and Molecular Biology and Medicine, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 274:7341-50. 1999..Induction of cyclin D1 activity by pp60(v-src) may contribute to breast tumorigenesis through phosphorylation and inactivation of the retinoblastoma protein...
- Evolutionary significance of intra-genome duplications on human chromosomesT Endo
Center for Information Biology, National Institute of Genetics, Mishima, Shizuoka, Japan
Gene 205:19-27. 1997..We also propose that a comparative mapping of paralogous genes within the human genome would be useful for identifying new genes...
- p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factNarayan R Bhat
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 277:29584-92. 2002....
- [Effects of Qishe Pill on vertebral hyperostosis induced by upright posture in rats]Qin Bian
Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Zhong Xi Yi Jie He Xue Bao 8:173-80. 2010..To observe the effects of Qishe Pill, a compound traditional Chinese herbal medicine, on lumbar vertebral bone formation induced by long-time upright posture in rats and to investigate the potential mechanism...
- High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cellsTusty Jiuan Hsieh
Université de Montréal Centre hospitalier de l Université de Montréal Hôtel Dieu, Centre de Recherche Pavillon Masson, Montreal, Quebec, Canada H2W 1T8
Endocrinology 144:4338-49. 2003..Our studies demonstrate that the stimulatory effect of high glucose on ANG gene expression and IRPTC hypertrophy may be mediated at least in part via activation of hexosamine biosynthesis pathway signaling...
- Changes in expression of p38 mitogen-activated protein kinase in the dorsal motor nucleus of the vagus nerve and hypoglossal nucleus after axotomy in adult ratsTatsuo Shimokawara
Department of Pathology, Nara Medical University, Kashihara, Japan
Neuropathology 22:261-8. 2002..Moreover, perineuronal microglial cells showed strong expression of p38 MAP kinase, active and inactive, after axotomy in both nuclei. These findings suggest that p38 MAP kinase is related to microglial cell reactions after axotomy...
- Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimerR Hara
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
J Biol Chem 274:24779-86. 1999....
- Towards the identification of (a) gene(s) for autosomal dominant medullary cystic kidney diseaseFrancesco Scolari
Division and Chair of Nephrology, Spedali Civili, Brescia, Italy
J Nephrol 16:321-8. 2003..The gene for familial juvenile hyperuricemic nephropathy (FJHN), a phenotype that is very similar to MCKD, was recently mapped to 16p12, in a region overlapping with the MCKD2 ..
- General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2Shibing Yu
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
J Biol Chem 283:5542-53. 2008..This study shows that a general transcription factor, TFIIA gamma, facilitates osteoblast-specific gene expression through interactions with two important bone transcription factors ATF4 and Runx2...
- The osteoinductive properties of Nell-1 in a rat spinal fusion modelSteven S Lu
Dental and Craniofacial Research Institutes, UCLA School of Dentistry, Los Angeles, CA 90095, USA
Spine J 7:50-60. 2007..Previous studies showed that Nell-1 accelerates osteogenic differentiation in vitro and calvarial bone formation in vivo. We hypothesize that Nell-1 may also effectively form bone in spinal fusion...
- Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cellsHassan El Btaouri
Laboratoire SiRMa Signalisation Cellulaire et Récepteurs Matriciels, UMR CNRS 6237, UFR Sciences, Reims, France
Biochim Biophys Acta 1813:695-703. 2011..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
- Differential expression of activating transcription factor-2 and c-Jun in the immature and adult rat hippocampus following lithium-pilocarpine induced status epilepticusSi Ryung Han
Department of Neurology, The Catholic University of Korea, Seoul, Korea
Yonsei Med J 50:200-5. 2009..Therefore, we investigated the expression of c-Jun and ATF-2 protein in the immature and adult rat hippocampus to understand their roles in LPSE-induced neuronal death...
- Response of human alveolar bone-derived cells to a novel poly(vinylidene fluoride-trifluoroethylene)/barium titanate membraneL N Teixeira
Department of Morphology, Stomatology and Physiology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
J Mater Sci Mater Med 22:151-8. 2011..Further in vivo experiments should be carried out to confirm the capacity of P(VDF-TrFE)/BT membrane in promoting bone formation in guided bone regeneration...
- Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factorsD J Kroll
Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262
Mol Endocrinol 7:305-18. 1993....
- The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effectM T F Wolf
Department of Pediatric Nephrology of the University Children s Hospital, University of Cologne, Cologne, Germany
Kidney Int 71:574-81. 2007..in the Uromodulin (UMOD) gene were published in patients with familial juvenile hyperuricemic nephropathy (FJHN) and MCKD2. Clinical data and blood samples of 16 affected individuals from 11 different kindreds were collected...
- Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activationJunzo Hisatsune
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
J Immunol 180:5017-27. 2008..Thus, in U937 cells, VacA directly increases IL-8 production by activation of the p38 MAPK via intracellular Ca(2+) release, leading to activation of the transcription factors, ATF-2, CREB, and NF-kappaB...
- Role of nutritional zinc in the prevention of osteoporosisMasayoshi Yamaguchi
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322 0001, USA
Mol Cell Biochem 338:241-54. 2010..Zinc compounds may be designed as new supplementation factor in the prevention and therapy of osteoporosis...
- Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cellsLan Xiao
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 18:4579-90. 2007..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis...
- Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brainS Brecht
Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Hospitalstrasse 4, 24105, Kiel, Germany
Neuroscience 120:1037-48. 2003..However, changes of FKBP enzymatic activity result in suppression of the stress cell body response in the peri-infarct area as observed by suppression of c-Jun phosphorylation and Fas-L expression...
- p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1Ming Chang Hu
Division of Nephrology, Program in Developmental Biology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
J Biol Chem 279:12051-9. 2004..We conclude that BMP7 stimulates renal epithelial cell morphogenesis via p38(MAPK) and that p38(MAPK) activity is negatively regulated by Smad1...
- Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expressionHarufumi Yamasaki
Department of Biology, Faculty of Science, Shizuoka University, 836 Oya, Surugaku, Shizuoka City, Shizuoka 422 8529, Japan
Development 133:4233-43. 2006..biliary cell differentiation and gene expression of the regulatory genes for that differentiation, including Hnf1b and Hnf6...
- Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large familyN Kamatani
Institute of Rheumatology, Tokyo Women s Medical University, Japan
Arthritis Rheum 43:925-9. 2000Familial juvenile hyperuricemic nephropathy (FJHN, MIM 162000) is an autosomal-dominant disease characterized by underexcretion-type hyperuricemia, gout, and chronic renal failure...
- The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repairJun Hayakawa
Department of Cancer Gene Therapy, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
J Biol Chem 278:20582-92. 2003..JNK may be a rational target for sensitizing tumor cells to DNA-damaging chemotherapy agents...
- Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinomaYing Qiu
Department of Pathology, Tongji University School of Medicine, Shanghai 200092, China
Cancer Sci 100:1198-209. 2009..PBX2 is a transcription factor for VCP in NSCLC. Because high levels of PBX2 expression correlated with prognosis of NSCLC, PBX2 could be a target molecule for treatment of NSCLC...
- Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6Randolph P Matthews
Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Development 132:5295-306. 2005..with this, reduced vps33b expression was evident in hnf6-deficient larvae and in larvae with mutation of vhnf1, a downstream target of hnf6...
- JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promotersDong Chen
Division of Reproductive Biology Research, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Mol Endocrinol 25:767-75. 2011..3/II via CRE(-211/-199). JunB also activates aromatase promoters I.3/II by maintaining JunD expression. Targeting JunD may abolish aromatase expression selectively in breast cancer tissue...
- Activating transcription factor 2 controls Bcl-2 promoter activity in growth plate chondrocytesQin Ma
Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610 0235, USA
J Cell Biochem 101:477-87. 2007..These data identify the Bcl-2 gene as a novel target of ATF-2 and CREB in growth plate chondrocytes...
- Familial nephropathy associated with hyperuricemia in Spain: our experience with 3 families harbouring a UMOD mutationJ G Puig
Division of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain
Nucleosides Nucleotides Nucleic Acids 25:1295-300. 2006Since 1993 we have studied 5 Spanish families with familial nephropathy associated with hyperuricemia (FJHN). Among these families, 24 patients have been identified...
- High glucose alters the expression of genes involved in proliferation and cell-fate specification of embryonic neural stem cellsJ Fu
Molecular Neurobiology Laboratory, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Diabetologia 49:1027-38. 2006....
- Cbfbeta interacts with Runx2 and has a critical role in bone developmentMondira Kundu
Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Building 49, Room 3A26, Bethesda, Maryland 20892, USA
Nat Genet 32:639-44. 2002..Our findings raise the possibility that mutations in CBFB may be responsible for some cases of cleidocranial dysplasia that are not linked to mutations in RUNX2...
- Runx2 deficiency in chondrocytes causes adipogenic changes in vitroHirayuki Enomoto
Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
J Cell Sci 117:417-25. 2004..Our findings suggest that these Runx2-dependent functions are mediated, at least in part, by interleukin-11...
- Phosphorylation of Activation Transcription Factor-2 at Serine 121 by Protein Kinase C Controls c-Jun-mediated Activation of TranscriptionTakahito Yamasaki
Gene Engineering Division, RIKEN BioResource Center, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074
J Biol Chem 284:8567-81. 2009..Our results suggest that the phosphorylation of ATF-2 at Ser-121 plays a key role in the c-Jun-mediated activation of transcription that occurs in response to TPA...
- Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38Ted Kamenecka
Department of Molecular Therapeutics and Translational Research Institute, The Scripps Research Institute, Jupiter, FL 33458, USA
J Biol Chem 284:12853-61. 2009....
- Familial juvenile hyperuricemic nephropathy and autosomal dominant medullary cystic kidney disease type 2: two facets of the same disease?K Dahan
Center for Human Genetics, Catholic University of Louvain, Brussels, Belgium
J Am Soc Nephrol 12:2348-57. 2001Familial juvenile hyperuricemic nephropathy (FJHN) is an autosomal dominant disorder heralded by hyperuricemia during childhood; it is characterized by chronic interstitial nephritis, with marked thickening of tubular basement membranes, ..
- A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulinKarin Dahan
Universite Catholique de Louvain, Center for Human Genetics, Brussels, Belgium
J Am Soc Nephrol 14:2883-93. 2003Familial juvenile hyperuricemic nephropathy (FJHN [MIM 162000]) is an autosomal-dominant disorder characterized by abnormal tubular handling of urate and late development of chronic interstitial nephritis leading to progressive renal ..
- vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesisLudmilla Lokmane
UMR7622 CNRS Université Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
Development 137:347-57. 2010..Here, we identify the transcription factor vHNF1 (HNF1beta) as a crucial regulator of these early developmental events...
- Monogenic diabetes mellitus in youth. The MODY syndromesW E Winter
Department of Pathology, Immunology, University of Florida College of Medicine, Gainesville, USA
Endocrinol Metab Clin North Am 28:765-85. 1999..HNF-1 alpha, MODY3), insulin promoter factor-1 (IPF-1, MODY4), and hepatocyte nuclear factor-1 beta (HNF-1 beta, MODY5)...
- Dissecting the nutrigenomics, diabetes, and gastrointestinal disease interface: from risk assessment to health interventionLynnette R Ferguson
The University of Auckland, Auckland, New Zealand
OMICS 12:237-44. 2008..rectifying channel, subfamily J, member 11 gene; PPAR-gamma, peroxisome proliferator activated receptor-gamma; TCF2, transcription factor 2, hepatic; WFS1, Wolfram syndrome 1...
- Sustained increases in activating transcription factor-2 and activator protein-2 in the rat supraoptic nucleus during water deprivationRick B Meeker
Department of Neurology, University of North Carolina, Chapel Hill, 27599, USA
Neuroendocrinology 76:111-20. 2002....
- Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choiceJing Wei Zhao
Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
Eur J Neurosci 29:1853-69. 2009..We also observed Olig2(TL)GFAP(+) cells that appeared after injury and before the NG2(+)GFAP(+) phenotype. This suggests that not all astrocytes are derived from an NG2(+) population...
- Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-alpha gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblastsWissam H Faour
Department of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
J Biol Chem 280:9536-46. 2005..We suggest that egr-1 is an immediate-early PGE2 target gene that may be a key regulatory factor in mediating eicosanoid control of genes involved in the immune and inflammatory responses...
- Association of activating transcription factor 2 (ATF2) with the ubiquitin-conjugating enzyme hUBC9. Implication of the ubiquitin/proteasome pathway in regulation of ATF2 in T cellsR Firestein
Center for Gerontology, Allegheny University of the Health Sciences and the Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 273:5892-902. 1998..d) A proteasome inhibitor delays the down-regulation of ATF2 phophorylation after T cell activation. Taken collectively, these results implicate a role for hUBC9 and the ubiquitin/proteasome pathway in regulation of ATF2 in T cells...
- Mutation analysis of the Uromodulin gene in 96 individuals with urinary tract anomalies (CAKUT)Matthias T F Wolf
Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
Pediatr Nephrol 24:55-60. 2009..UMOD transcription is activated by the transcription factor HNF1B. Mutations in HNF1B cause a phenotype similar to FJHN/GCKD but also congenital anomalies of the kidney and the ..
- Molecular markers of early orthodontic tooth movementPatricia Joyce Brooks
Orthodontic Department, Faculty of Dentistry, University of Toronto, Toronto, Canada
Angle Orthod 79:1108-13. 2009..To understand the molecular basis of early orthodontic tooth movement by looking at the expression of KI-67, runt-related transcription factor 2 (Runx2), and tumor necrosis factor ligand superfamily member 11 (RANKL) proteins...
- Insulin-regulated gene expressionR M O'Brien
Department of Molecular Physiology and Biophysics, 761 MRB II, Vanderbilt University Medical School, Nashville, TN 37232, USA
Biochem Soc Trans 29:552-8. 2001..In addition, in the G6Pase catalytic subunit promoter, hepatocyte nuclear factor 1 ('HNF-1'), acts as an accessory factor to enhance the effect of insulin mediated through the IRS...
- Lack of TCF2/vHNF1 in mice leads to pancreas agenesisC Haumaitre
Biologie du Développement, Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
Proc Natl Acad Sci U S A 102:1490-5. 2005Heterozygous mutations in the human POU-homeobox TCF2 (vHNF1, HNF1beta) gene are associated with maturity-onset diabetes of the young, type 5, and abnormal urogenital tract development...
- Theoretical investigation of hydrogen bonds between CO and HNF2, H2NF, and HNOAn Yong Li
School of Chemistry and Chemical Engineering, Southwestern University, 400715, Chongqing, P R China
J Phys Chem A 110:10805-16. 2006Ab initio quantum mechanics methods were applied to investigate the hydrogen bonds between CO and HNF2, H2NF, and HNO...
- Variant hepatocyte nuclear factor 1 is required for visceral endoderm specificationE Barbacci
U423 INSERM, Hopital Necker Enfants Malades, France U257 INSERM, ICGM, France
Development 126:4795-805. 1999..We show that variant Hepatocyte Nuclear Factor 1 (vHNF1), a homeodomain-containing transcription factor first expressed in the primitive endoderm, is required for the ..
- Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen geneAkiro Higashikawa
Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Arthritis Rheum 60:166-78. 2009..Aiming at clinical application, this study was undertaken to investigate transcriptional regulation of human type X collagen by RUNX-2 in human cells...
- Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancerH Kayed
Department of General Surgery, University of Heidelberg, Heidelberg, Germany
Br J Cancer 97:1106-15. 2007..In addition, Runx2 has the potential to regulate the transcription of extracellular matrix modulators such as SPARC and MMP1, thereby influencing the tumour microenvironment...
- Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiationC Coffinier
Unite des Virus Oncogenes, CNRS URA 1644, and Unité de Biologie du Développement, CNRS URA 1960, Institut Pasteur, F 75724 Paris Cedex 15, France
Development 126:4785-94. 1999vHNF1/HNF1beta, a member of the divergent HNF1/vHNF1 homeoprotein family, is expressed in polarized epithelia of several adult organs and may participate in controlling the transcription of specific genes...
- Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1Anatoliy Kravets
Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Biol Chem 279:19916-23. 2004..We propose that increased expression of the protein can be used to alter the gene expression profile in the cell...
- Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathyT C Hart
University of Pittsburgh, School of Dental Medicine, Division of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Med Genet 39:882-92. 2002Medullary cystic kidney disease 2 (MCKD2) and familial juvenile hyperuricaemic nephropathy (FJHN) are both autosomal dominant renal diseases characterised by juvenile onset of hyperuricaemia, gout, and progressive renal failure...
- Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expressionKendra Sturgeon
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
Development 138:65-74. 2011..The homeodomain protein vHnf1 (Hnf1b) directly activates Mafb expression...
- A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cellsAurélie V Poll
Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
Diabetes 55:61-9. 2006..Among the latter, variant HNF1 (vHNF1)/TCF2, which is expressed before HNF6 in the endoderm, was found to be critical for HNF6 expression...
- Functions of HNF1 family members in differentiation of the visceral endoderm cell lineageCécile Haumaitre
Unité 423 INSERM, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
J Biol Chem 278:40933-42. 2003The two members of the hepatocyte nuclear factor 1 (HNF1) transcription factor family, HNF1 and variant HNF1 (vHNF1), show a strong homology in their atypical POU-homeodomain and dimerization domain but differ in their transactivation ..
- The unfolded protein response and the phosphorylations of activating transcription factor 2 in the trans-activation of il23a promoter produced by β-glucansMario Rodriguez
From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid
J Biol Chem 289:22942-57. 2014....
- Uromodulin storage diseases: clinical aspects and mechanismsFrancesco Scolari
Divisione di Nefrologia, Spedali Civili, Brescia, Italy
Am J Kidney Dis 44:987-99. 2004..in patients with medullary cystic kidney disease type 2 (MCKD2), familial juvenile hyperuricemic nephropathy (FJHN), and glomerulocystic kidney disease (GCKD) provides the opportunity for a revision of pathogenic aspects and puts ..
- Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancerHui Shen
USC Epigenome Center, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA
Nat Commun 4:1628. 2013b>HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ..
- Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort ConsortiumMitchell J Machiela
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 176:1121-9. 2012..Ten T2D markers near 9 loci (NOTCH2, ADCY5, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, MTNR1B, FTO, and HNF1B) were nominally associated with PCa (P < 0...
- Alterations of uromodulin biology: a common denominator of the genetically heterogeneous FJHN/MCKD syndromeP Vylet'al
Center for Applied Genomics, Charles University 1st School of Medicine, Prague, Czech Republic
Kidney Int 70:1155-69. 2006..Uromodulin-associated kidney diseases' may be thus a more appropriate term for this syndrome...
- Expression of activating transcription factor 2 in inflammatory macrophages in obese adipose tissueYugo Miyata
Obesity (Silver Spring) . 2012..These results suggest that ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 in M1 macrophages of WAT...
- Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activityChih Chao Hsu
Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA
J Biol Chem 287:8621-32. 2012....
- The role of pancreatic imaging in monogenic diabetes mellitusIngfrid S Haldorsen
Department of Radiology, Haukeland University Hospital, N 5021 Bergen, Norway
Nat Rev Endocrinol 8:148-59. 2012In neonatal diabetes mellitus resulting from mutations in EIF2AK3, PTF1A, HNF1B, PDX1 or RFX6, pancreatic aplasia or hypoplasia is typical...
- Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptorTomohiko Sase
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
Int J Cancer 131:2284-93. 2012....
- hnf1b genes in zebrafish hindbrain developmentSeong Kyu Choe
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
Zebrafish 5:179-87. 2008The Hnf1b transcription factor acts during formation of rhombomeres (r) 5 and 6 in the hindbrain. To determine if hnf1b is absolutely required in r5/r6, we examined the hnf1b(hi2169) and hnf1b(hi1843) retroviral insertion alleles...
- Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epitheliumAnna D'Angelo
Expression Génique, Développement et Maladies Equipe 26 INSERM U567 CNRS UMR 8104 Université Paris Descartes Institut Cochin Dpt Génétique et Développement, 75014 Paris, France
Development 137:1573-82. 2010..With the use of a conditional inactivation system, we generated mice in which Hnf1b is specifically inactivated in the intestinal epithelium on a wild-type or Hnf1a(-/-) genetic background...
- A set of polyclonal and monoclonal antibodies reveals major differences in post-translational modification of the rat HNF1 and vHNF1 homeoproteinsT Chouard
URA 1644 du CNRS, Departement des Biotechnologies, Paris, France
Biochimie 79:707-15. 1997The related homeodomain-containing transcription factors HNF1 (HNF1 alpha) and vHNF1 (HNF1 beta) recognise common target DNA sequences in the regulatory regions of many genes and are expressed in several parenchymal cell types, ..
- vHnf1 regulates specification of caudal rhombomere identity in the chick hindbrainFerran Aragon
Developmental Biology Group, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
Dev Dyn 234:567-76. 2005The homeobox-containing gene variant hepatocyte nuclear factor-1 (vHnf1) has recently been shown to be involved in zebrafish caudal hindbrain specification, notably in the activation of MafB and Kro x 20 expression...
Research Grants18
- The PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanomaERIC KIRK LAU; Fiscal Year: 2013..abstract_text> ..
- Molecular Mechanism of Arterial StiffeningZhongjie Sun; Fiscal Year: 2013..Completion of the project may offer a new therapeutic approach for large artery stiffening and related cardiovascular disorders. The finding will benefit the US population which has a high prevalence of cardiovascular disease. ..
- Nell-1, A Cbfa 1 Downstream Target, In Bone FormationKang Ting; Fiscal Year: 2009..A better understanding of how and why Nell-1 works to form bone can accelerate the development of clinical therapies to help patients grow better and faster bone. ..
- Novel Mechanism of PTH Effects on Bone MetabolismBin Wang; Fiscal Year: 2013....
- Roles of Growth Factors on Corneal MorphogenesisWinston W Kao; Fiscal Year: 2013..These experiments will yield useful information for restoration of normal vision by intervening TBR2 and ATF2 signaling pathways of injured corneas. ..
- Regionalization of the Vertebrate EndodermVictoria E Prince; Fiscal Year: 2013..the roles of two additional candidate RA-targets previously implicated in early pancreas development: the Hb9 and Tcf2 transcription factors...
- Hhex-a Homeobox Gene Necessary for Liver DevelopmentClifford W Bogue; Fiscal Year: 2010..Furthermore, we showed that deletion of Hhex is associated with decreased expression of Hnf4a, Hnf1b (TCF2) and Onecut1 (Hnf6), suggesting that Hhex regulates, either directly or indirectly, the expression of these ..
- Regulation of the P.aeruginosa Type III Secretion System by the Multifaceted TranFlorian David Schubot; Fiscal Year: 2013..Lastly, we will determine the crystal structure of the regulatory domain of ExsA. This will be the first structure reported for this type of domain and may offer intriguing new insights into its functiona role. ..
- Mechanisms of Bile Duct MorphogenesisBen Z Stanger; Fiscal Year: 2013..g. hnf1b, hnf6, tgfb)...
- REGULATION AND FUNCTION OF HEAT SHOCK FACTORS IN TESTISKEVIN SARGE; Fiscal Year: 1999..This information will provide a framework for exploring disease processes which affect spermatogenesis, and for development of new male contraceptives. ..
- Heat shock proteins and alcohol induced liver injuryPranoti Mandrekar; Fiscal Year: 2006....
- REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSIONPeter Igarashi; Fiscal Year: 2010..Humans with mutations of HNF-13 develop maturity-onset diabetes of the young type 5 (MODY5) and congenital cystic abnormalities of the kidney...
- Variant detection and variant analysis process for diagnosis of CH and MODYDavid Margulies; Fiscal Year: 2006..is of particular concern for the diagnosis of diseases commonly associated with large deletions in a gene, such as MODY5 (Bellanne-Chantelot, 2005)...
- FUNCTIONAL ANALYSIS OF VEFZ1, A NOVEL ENDOTHELIAL MARKERHeidi Stuhlmann; Fiscal Year: 2003..These include congenital cardiovascular abnormalities and pathological conditions such as rheumatoid arthritis, retinopathies, hemangiomas, psoriasis, solid tumors and metastases. ..
- Specification and Positioning of the PancreasCHARLES SAGERSTROM; Fiscal Year: 2005..k.a Hnfl1beta), which is mutated in MODY5 and has recently been implicated in early pancreas development, binds Meis3 and Pbx4 and we will therefore explore ..
- Early development of the zebrafish pancreasAndrea Ward; Fiscal Year: 2006..The second aim of my study will test whether tcf2 and hb9 are downstream targets of retinoic acid in specifying beta-cells...
- Immune Regulation of Cysteinyl Leukotriene BiosynthesisBing K Lam; Fiscal Year: 2010....
- Genome Wide Mapping of in-vivo protein: DNA interactionsSANDRA SHARP; Fiscal Year: 2003....


text:
Established in January of 1998, CHRISTRIO was developed to make nail products less complicated and to promote profitable and successful businesses, providing better products to nail salons. The company also offers courses in beginner, advanced, intermediate, and Educational Sales Consultant (ESC) in both acrylic and gel, through their Institute of Advanced Nailery.
Financing was also provided by Plaza Bank, a community business bank located in Southern California and Southern Nevada.
"Plaza Bank stepped up late in the game when the client was left stranded by another bank," said Todd Massas, Senior Vice President of Plaza Bank. "We approved the loan in just one day and brought Mercantile in to assist with the bridge financing. With their help, we were able to meet the year end close of escrow requirement."
The SBA 504 loan program helps owners of small to mid-sized businesses, like CHRISTRIO, have an opportunity to create wealth and financial freedom. It allows borrowers to own their commercial property with the highest cash-on-cash return financing available, without tying up their precious capital, so they can grow even faster.
For more information, visit www.504Experts.com and www.504Blog.com.
+Chris Hurn
Entrepreneur, Speaker, Writer/Blogger, Leader. Mercantile Capital Corporation only finances commercial real estate for other entrepreneurs and small business owners all over the U.S. utilizing the SmartChoice Commercial Loan program (aka the SBA 504 loan).
Chris Hurn, Mercantile Capital Corporation, 407-786-5040

subset: commoncrawl


text:
'Taste of Vine' Oct. 14 showcases The Vineyards, raises funds for Free Clinic
A special event to experience fine wines and a remarkably renovated restaurant, The Vineyards, in Simi Valley, while simultaneously raising needed funds for the Free Clinic of Simi Valley is set for Thursday, Oct. 14.
The "Taste of Vine" celebration of sunset views, wine, gourmet food pairings and jewelry and art vendors is scheduled for 7 to 10 p.m. Oct. 14 at The Vineyards, 2525 Stow Street in east Simi Valley.
"This is an opportunity to see a wonderful, recently renovated venue at a premiere hilltop location in Simi Valley, and taste some of the nation's finest wines with excellent food pairings in a sunset setting," said Samantha Evans of TruLuxe Event Planning. "And we will be raising much-needed funds for the Free Clinic of Simi Valley in the process."
A portion of proceeds from the event will be donated to the nonprofit Free Clinic, which provides medical care, counseling, dental and legal assistance to Simi Valley individuals and families, regardless of their ability to pay.
Taste of Vine will feature wine tastings with professional food pairings; meal demonstrations; jewelry vendors; and art presentations. Vendors are selected for hands-on attention with guests, the schedule is arranged so participants can enjoy every offering if so desired, and there will be plenty of samples, Evans said.
The event will present residents from Simi Valley and the surrounding region a look at significant improvements to The Vineyards, a prominent restaurant atop a hill overlooking east Simi Valley with spectacular views next to waterfalls and glass terraces.
For more information or for tickets or sponsorship opportunities, please visit http://www.tasteofvine.com.
For more information about the Free Clinic of Simi Valley, please visit http://www.freeclinicsv.com.
Subscribe to the Ventura County Star
Need Help? Call us at 1-877-710-6182.
Monday-Friday: 6am-3pm / Saturday: 6:30am-10:30am / Sunday: 7am-11am


text:
1 Park near Bolivar, Missouri
Pittsburg, Missouri 16.63 miles NE
Dadeville, Missouri 17.1 miles SW
Stockton, Missouri 21.84 miles NW
Hermitage, Missouri 23.02 miles NE
Bolivar, Missouri (map) | (417) 599-8504
Sites: 29 | Latest Rate: $26.00 | 3 Reviews
|Clean Restrooms:
|Clean Showers:
Jun 2014 - $26.00
Overall a good place to stay. Not a resort, no pool but several things to do in the area. No cable but lots of over the air stations from Springfield. - kenp
Dec 2012 - $12.00
We stayed here for one night between Christmas and New Years. We called ahead and were met by the manager who directed us to our site and helped us get hooked up. He was very friendly and helpful. Despite the cold weather outside, the bathrooms and showers were warm and very clean. We used the Passport America rate. A good spot for an overnight stay. We will use it again when we pass through. - Kansas Traveler
May 2012 - $25.00
This park has recently undergone an update. It is located behind the Red Cedar Motel. There are both pull-thru and back-in sites which are level gravel pads. There is a covered patio attached to the building with the restrooms and laundry room. - BOTRA


text:
How To Make A Black Forest Trifle - Part 1
|Canned black cherries
|425 Gram (in syrup)
|Chocolate finger cake/Marble cake
|250 Gram
|4 Tablespoon
|Dark chocolate
|100 Gram (plain bar)
|Fresh vanilla custard
|500 Gram
|Double cream
|300 Milliliter
|Single cream
|150 Milliliter
|Icing sugar
|1 Tablespoon
|Vanilla extract
|1⁄2 Teaspoon
1. Drain the cherries in a sieve over a bowl and reserve the syrup. Set the cherries aside.
2. In the base of a large trifle bowl, arrange half of the finger cakes, breaking them in half as you put them in. Spoon over 6 tablespoons of cherry juice and 2 tablespoon kirsch.
3. Grate about 2 tablespoons of chocolate from the bar. Set aside for decoration.
4. Melt the rest of the chocolate in a bowl, in the microwave oven.
5. In a bowl, warm the custard for a minute in the microwave oven, stirring halfway.
6. Mix just over half the melted chocolate into the warm custard and beat well.
7. Spread out the rest of the melted chocolate on a baking parchment. Chill for 10 minutes and cut out star shapes from the set chocolate.
8. In a bowl add double cream and single cream together with the icing sugar and vanilla, and whisk using a hand whisk, until just thickened.
9. Scatter half of the cherries over the cake mixture. Spoon about a third of the cream mixture over the cherries.
10. Add the rest of the cake, broken in halves, spoon over 2 more tablespoons of the cherry syrup and 1 tablespoon of kirsch, then add the rest of the cherries.
11. Spoon the chocolate custard over, and add spoonfuls of cream on top.
12. Sprinkle with grated chocolate. And stick the star shapes on top of the cream.
13. Scoop the Black Forest Trifle into serving bowls and serve.


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You can now invite anyone to meet at your favorite Starbucks.
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57 year old man | Coopersburg, PA, USA | Seeking women 48-55 within 30 miles
Here I am... Where are you? I hope your the one!! BE HONEST, SINCERE AND TRUTHFUL... but most important... BE YOURSELF!!
I am somewhat old fashioned. I believe in opening a door for a lady and believe that chivalry is still alive. I live in jeans and T-shirts, but enjoy dressing up now and then. Some of my interests and things I enjoy are photography, woodworking, building things, working on my house, rocketry, sport pistol shooting and trap shooting, archery, attending drag racing events, motocross, swimming and working out in my basement. I love coffee! Coffee and conversation is a fine pastime when spent with that special someone. However, being with that special someone means any activity is enjoyable, as long as we are together, Going for walks, walking in new fallen snow, watching movies and DVD's, visiting parks and restaurants and again... drinking coffee! A walk or being together on a cool, clear, calm, beautiful evening would be an everlasting memory. I recently bought a motorcycle and am having it made into a trike over the winter... safer and more relaxing riding that way. I want to ride... everywhere! Have been in all but 10 states, but now want to ride all over the nation... on the trike! Horses?... would like to ride them, if someone would help me along! Had a horse throw me off when I was a kid, and wanna get over that. I really believe in "spontaneity of the moment"... in everything! Just pick up and go at the drop of a hat... no prior plans. I do believe in long term planning, but not always! More fun and adventurous that way... get the idea?! I have a 20 year old son that means the world to me, he lives with me, but is independant, so I am not tied or commited to anyone and wish that of my partner. My friends all know and describe me as funny, but very serious about what I do, very fussy and being a perfectionist. My son and I are in the process of building a fire pit out behind my pool, to enjoy cozy evenings with that special someone. I love the holidays, and would enjoy them even more with the right person. I am not into the night club scene or mutual dating, as I am a "one woman man." I am looking for a sincere, honest, compassionate be-yourself woman who seeks the same that hopefully will develop into a loving, intimate, long term permanent relationship. I am a faithful person who does not play games and expects the same. Honest communication is the key element and is vitally essential for a true relationship. Controlling, jealous and spiteful people will not work. A few of my desires is to see Italy, the pyramids of Eqypt and take an Alaskan cruise... again with that "SPECIAL SOMEONE" Many of my friends and family say I look grouchy in photos, as I seldom smile... trust me, I'm not! My photos are recent and I look for the same from you. Looking forward to meeting that "Special Someone" to love and grow old together with! One last thing... its seems in today's society that so many use the term, "wife beater's" to label sleeveless T-shirts or Tank Top T-shirts. That is such an immature assessment to label one or pass judgement on someone who wears sleeveless or Tank Top shirts. I say this because I wear them and I am very comfortable in them, so, if you view my profile, PLEASE do not label me in that category.
Coffee and conversation , Dining out , Hobbies and crafts , Movies/Videos , Music and concerts , Exploring new areas , Travel/Sightseeing
Auto racing / Motorcross, Bowling, Golf, Other types of exercise, Swimming, Walking / Hiking, Weights / Machines
I exercise 1-2 times per week.
I like Dogs, Fish
I like dogs, cocker spaniels and golden retreivers to be exact. I do not trust protective dogs, as I have had some really bad experiences with them. I had a German Shepard for 12 years and it broke my heart to have him put down... that was in 1981.
Middle of the Road
Any place will do as long as it is spent with that special someone. I would love to travel more, I have been throughout most of the US, and I love the southwest.
Italian food, 70's and 80's rock, country & classical music. Skeet & trap shooting, handgun sport shooting. Science and educational shows like Nat Geo, Discovery, Travel channel, etc. Real scary movies. My favorite color is red.
Movies, woodworking, rocketry, go for walks, attend events. Working on my home. But more than ever, go places and spend time with that special someone.
American Woodworker magazine, ROCKETS magazine... I generally fall asleep reading!
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'8" (172cms)
|5'0" (152cms) to 5'8" (172cms)
|Body type:
|Athletic and toned
|Slender, About average, Curvy, Athletic and toned
|Black, Blue, Brown, Grey, Green, Hazel
|Salt and pepper
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way
|Social Drinker
|Social Drinker
|Labor / Construction
|Administrative / Secretarial, Executive / Management, Financial / Accounting / Real Estate, Labor / Construction, Medical / Dental / Veterinary / Fitness, Retail / Food services, Sales / Marketing, Education / Teacher / Professor, Technical / Science / Computers / Engineering, Travel / Hospitality / Transportation, Law enforcement / Security / Military
I have been in Electronic Security since I was 11 years old, I am doing this all my life. I had my own photography business for 34 years, specializing in wedding photography. I still love photography.
|$35,001 to $50,000
|Less Than $25,000, $25,001 to $35,000, $35,001 to $50,000
|Never Married, Widow / Widower, Divorced
|Have kids:
|Yes, and they live at home (1)
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|No, No, but it's OK if my partner has kids
|White / Caucasian
|White / Caucasian
|Christian / Catholic
|Christian / Catholic, Christian / Protestant
Born and raised Catholic, I DO believe in God, but do not attend church.
|High school
|High school


text:
FC Rocket
94 reviews
By installing you agree to the Terms of Use and other terms
PublisherElectronic Arts
More from Electronic Arts
Download size41 MB
Content rating
Last updated5/20/2014
Works with
- Windows Phone 8.1
- Windows Phone 8
- Windows Phone 7.5
App requires
- Xbox
- photo, music, and video libraries
- data services
- web browser component
- HD720P (720x1280)
- WVGA (480x800)
- WXGA (768x1280)
*Not available for all phones Learn more
Supported languages (12)
Deutsch English (United States) Español Español (España, alfabetización internacional) français italiano polski português (Brasil) português (Portugal) русский 中文(简体) 中文(繁體)
It's Flight Control… But Not As You Know It! Flight Control Rocket is the next evolution of Firemint's genre-defining #1 hit, Flight Control. Leave the terrestrial skies of Earth and venture into a whole new galaxy of adventure, action, and addictive path-drawing gameplay! ✈ NEW VOYAGES AWAIT • 10 new Motherships! • New 'Rescue' game mode! • 4 new Bots! ✈ Simple Game, Stellar Content • The classic Flight Control experience – but with a retro Sci-Fi inspired flavor and pace all of its own• 15 spacecraft with unique abilities and characteristics • Thrilling game modes such as the fast-paced Infinity and the expansive Odyssey • A cast of quirky Robots with special powers that help boost your score ✈ Unlimited Fun • Unlock a near endless number of stages. Push onward and venture to the farthest frontiers… • Multiple lives means one collision isn't the end of your daring ion-powered adventure. The galaxy loves a risk-taker… • Keep your fleet fully stocked with goodies from the Shop • Compete with the galaxy's top captains on the online leaderboardsPrepare to be amazed… your trip through the vast unknown is about to begin!
4/26/2015much better than Flight Control...but the achievements are wayyy too grindy
4/6/2015Great game
11/22/2014Este juego es superduperfantasticoooooooooooo
7/27/2014Reminds me of flight control but its a little conjusted game ! Make it a bit simple !
7/19/2014please support 1080p
5/9/2014Its very boring need to add more stuff
4/30/2014It sucks . Half the time it won't f*cking work..
3/19/2014باحاله !


text:
S AFRICA: Distell cautious as FY profits dip
South African drinks group Distell has reported a dip in profits for its fiscal full-year, despite a solid increase in sales against a tough consumer climate.
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Learn how to perform basic image editing techniques such as cropping and resizing, selecting and masking, improving tone and contrast, and basic retouching, in GIMP, the free image editor for Mac and Windows.
Shows how to install and customize two free WordPress themes designed to create online photo portfolios.
Shows how to develop an interactive photo gallery for a web site using HTML, CSS, and jQuery.
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Search results for Real Housewives New Jersey
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Homecoming Scotland 2014
Homecoming Scotland 2014 reinforced Scotland's position on the international stage as a dynamic and creative nation. It extended the benefits and opportunities offered by the Commonwealth Games, MTV EMA and Ryder Cup and built on the successes of the first year of Homecoming 2009 by presenting a year-long coordinated programme of inspirational events. This programme was designed to support Scotland's events industry, increase visitors to Scotland and generate additional tourism revenue in a celebration of Scotland's past, present and future in the year that "Scotland welcomed the world". A record-breaking 2 million people have attended 1049 Homecoming events across Scotland in 2014.
The figure, which has been compiled from independent outcome reports and includes events such as Bannockburn Live, which attracted a capacity 20,000 crowd, Glasgow Film Festival, Perthshire Amber, East Neuk Festival and Scotland's Boat Show – all of which achieved record-breaking attendances during 2014.The success of Homecoming is testament to one of the biggest partnership campaigns ever, with event organisers, local and national government, local communities, schools, and businesses engaging with the special year across Scotland and beyond.


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Welcome to Giant Screen Films
Since 1997, Giant Screen Films (GSF) has established itself as a world leader in the large-format industry. Our mission is to create and distribute films that, through the magic of immersive sight and sound technologies, challenge the imaginations of children and adults—offering audiences an inspiring perspective on the world and an unforgettable theater experience.
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4/15/2015 - Praise for Journey to Space
2/27/2015 - Giant Screen Films to Launch Horses
2/20/2015 - K2 and GSF Partner with the GDTC on Journey to Space
Journey to Space is now in theaters. Trailer


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Lyndon Poskitt Racing - A blue print for Dakar 2013 - and he did it!
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Joined: Apr 2010
Location: Lincolnshire, UK
Oddometer: 41
Originally Posted by
Anna-Marie, CH-CH are start and end of the neutralization zone. The racing special has two parts today, Km 0 -> Km 229 is the first; then the timing clocks stop, the riders refuel and ride on the road for 97 km (probably avoiding a nature reserve zone or mining operations).
Then, at Km 326 (the 2nd blue CH), they are let off on the timed special again, racing the final 128 Km.
Clear as mud?
Originally Posted by
What he said! ^^^
Basically, it's a liason in the middle of the timed section, where "CH" means "Checkpoint" - each rider has to check in to each of these and is probably timed between the two, though this doesn't count as part of the result - there will be an average speed check between them and they'll probably receive a penalty if caught speeding.... (you can't get away from it nowadays!
Can I also say a big "ey-up" to Toldmum - it's great that you're on here and having followed Pyn's exploits all year (yep, I like most on here have the t-shirt!) it's great to see that this really is a family affair and you're all really behind him!
It's great to see all of the comments as you all know him better than us, so do please keep them coming!
The radio reports are great and really give an insight as to what is going on that we don't see - good work Packmule!
Thank you guys, It all becomes clear now. I didn't realise that section didn't count in the timings but I was aware of the speeding thing (there really is no getting away from it hey!!)
Another good day for Lyndon yesterday, thanks for keeping the call in's coming Nate It's good to hear his voice on a morning. Hope he got some good rest for a long day today.
GO Lyndon
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Kentuckians at War
Support Troops Prepare for Combat
By Marty Finley, The News-Enterprise
Members of the 3rd Expeditionary Sustainment Command are not known as a combat unit, but the group recognizes the need for readiness when it enters a war zone early next year. Part of the process to prepare bodies and minds for the upcoming deployment was unleashed in September on a padded wrestling mat in a gymnasium on Fort Knox. The exercise was part of combatives training, a multi-dimensional course in hand-to-hand combat completed in stages.


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HAYDN: String Quartet in C major, 'Emperor,', Op. 76, No. 3, HobIII:77
Composed by Franz Joseph Haydn (1732-1809). Instrumental Solo Part and CD. Published by Music Minus One (MO.MMOCD3133).
Item Number: MO.MMOCD3133
This third of six, the well-known 'Emperor' quartet, has a theme and variations subject of the slow movement which dories from a Croatian folk melody and was commissioned to be the Austrian National Anthem or 'Emperor's Hymn.' It became Haydn's personal favorite tune.
Contains a high-quality printed solo part and a compact disc featuring the quartet in split-channel stereo with the violinist on the right channel; then again in an accompaniment version minus the solo violin part.


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Monday, December 28, 2009
© Copyright 2015 Gwinnett Daily Post
SUWANEE -- North Gwinnett boys head coach Len Garner said that games are won in stretches and, fortunately for him, his team was able to put together one more stretch than Berkmar.
Facing the Patriots in the first round of the Jared Cook Holiday Classic at North Gwinnett on Monday night, the Bulldogs built a big lead in the third quarter only to hold off a late surge by Berkmar to post a 52-45 win.
Winners of last year's Powerade Festival, the win was the first step for North Gwinnett in winning the inaugural Jared Cook tournament.
"There's no doubt, our guys want to win this," Garner said as his team improved to 6-4. "We were able to go on a good run and build our lead up to 16 points and that made (Berkmar) have to fight back and do some other things they normally wouldn't do. (Berkmar) has really improved and they played hard tonight."
After leading 25-19 at the half, North looked like it had put Berkmar away with a solid 14-6 run to open the quarter, taking its biggest lead at 36-23 when Matt Walker scored off an assist from Carlton Rose with 2:51 left in the third.
After that, Berkmar (1-8) began to chip away, getting to within nine at 41-32 early in the fourth when Obu Obu scored on a lay up after a steal with 6:42 left to play.
"We've gotten down early in so many games this year but we've never quit," Berkmar head coach Greg Phillips said. "We've just got to learn to consistently play good from the beginning and not get down by 10 or 12 points so early."
A little over two minutes after Obu's basket, Wilson Murray made it even closer when he converted a three-point play with 5:19 left, cutting the score to 44-37, but Conner Day stretched the lead back out to 11 for the Bulldogs by scoring the game's next four points.
Still, Berkmar wouldn't go away, getting as close as 48-43 with 34 seconds left after a 3-pointer from Yonel Brown, who led the Patriots with 15 points.
But time eventually ran out on Berkmar, putting the Bulldogs into tonight's semifinals against Wesleyan at 8:10 p.m.
"It should be interesting," Garner said of tonight's game. "They shot the ball extremely well against Flowery Branch. We've also not played a match up zone the way they play it, so it should be a fun game."
Alex Tiller finished with 12 points to lead the Bulldogs while A.J. Clements added 11 points off the bench. Cyrus Lavant chipped in with 10 points while Walker snared 13 rebounds to go along with eight points.
Berkmar, which plays Flowery Branch today at 10:30 a.m., also received eight points from Murray while Obu tallied 11 rebounds and seven points.
Cook, the tournament's sponsor, is a North Gwinnett alumnist currently in his rookie year with the Tennessee Titans. He has donated several items of football memorabilia which are being raffled off to raise money for breast cancer research for the Susan G. Komen Foundation.
More like this story
- Berkmar's Obu finishes off Mustangs at buzzer
Patriots pick up key 8-AAAAA win over Meadowcreek boys ( January 31, 2009 )
- REGION 7-AAAAA: 13 proves lucky for North boys ( February 16, 2010 )
- Wesleyan holds on to beat North 66-64 ( December 29, 2009 )
- Patriots swept by McEachern ( February 27, 2010 )
- Blue Devils' stout 'D' key to win ( February 19, 2010 )


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The writings on the wall, graff vandalism
from ForestPunk – Fingers Up, Eyes Open Lyrics on Genius
"The writings on the wall" means whats gonna happen is gonna happen, or the future is predetermined, basically, its BOUT TO GO THE FUCK DOWN. Graff Vandalism is writting killer ass shit on walls of other peoples property, because, well…that's hip hop man. Graff=Writing on the Wall. Pretty Self Explanatory.
To help improve the quality of the lyrics, visit ForestPunk – Fingers Up, Eyes Open Lyrics and leave a suggestion at the bottom of the page


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Question: Actually i'm on ARHD 6.2.1 ICS ROM from xda Member mike. Later i want to try ICS MIUI ROM :-) My Question is, if i want to downgrade to this ROM after all, do i need to chage firmware again? At the moment i'm on 11.68.3504.00U_11.21.3504.13_2 (needed for ICS)
All you need to do is flash let's say eng hboot 1.17 for it to bootup without looping. Or anything below 1.23.


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House Ape
Joined: Feb 2003
Location: Ashland, OR, USA
Oddometer: 2,204
Solo F800GS down the CDR
The idea of riding the Continental Divide Trail popped into my head before I even took delivery of the F800GS last October. A friend of mine had done it on his R1200GS several years ago, so I knew that the lighter F800GS wasnt too cumbersome for it. In fact, from what I had read on several road reports posted here, it seemed pretty much like the ideal bike to me.
So once I took delivery of it, I set about farkling the bike for the journey, studying maps, and reading up on anything relating to the trail that I could find.
And then, on the morning of June 27th, I was ready to go. I had my Caribou panniers loaded with camping gear and tools, a duffel bag with some clothes was slung across the back rack, resting on an empty 2-gal. Rotopax canister that was going to be needed for a couple of stretches on the trail that exceeded the F800GSs tank range. My GPS was loaded with BigDogs track, and my Spot device was blinking away, allowing my wife to keep an eye on where the hell I was each day. And my trusty iPhone, with which I hoped to use to take pictures and keep a blog going, was in my front jacket pocket.
But it was inauspicious start.
I made it all of about six miles from my home in Ashland, Oregon. Didnt even make it as far as Medford before I noticed the bolt holding my right hand guard about to fall off. I pulled over and tightened it. But this little incident only served to remind me that I had neglected to pack the little tube of blue Loctite that I had pulled from my toolbox and placed ever so prominently on my workbench, so I wouldnt forget to pack it, you see.
The blue Loctite is not an optional item on this kind of a ride. There would be miles and miles of washboard ahead of me, and I expected that the bike will be ejecting parts like an out of control Kenmore washer on spin cycle if I didnt stay on top of all the bolts and screws with the magical blue Loctite.
Clearly, there was to be a stop at an auto parts store in my immediate future.
The first day was all about getting to the start of the real ride via the most direct route possible. That meant riding up Highway 97, and I hate riding up Highway 97.
Heading for 97 past Mt. Thielsen
Dont get me wrong, its a fine highway. But the State of Oregon, in its wisdom, has decided that all rural, two-lane roads should have 55 mph speed limits. In some places this makes sense. But east of the Cascades, where Highway 97 runs, it makes no sense at all. East of the Cascades is high desert country, with roads as straight as a Mormon missionary, and views up the road ahead stretch on for miles and miles to the horizon. You can see obstacles in the next time zone.
Every adjacent state has 65 or even 70 mph speed limits on their rural roads. But in Oregon our state motto is We Love Dreamers. And reality-based thinking is just too bourgeois for us (see Oregons gas dispensing laws).
So even though most motorists on 97 drive at a reasonable and safe 65 or 70 mph, there are always some Taliban-inspired drivers who feel it necessary to exert their control over the rest of us. And these true believers are easily identified by the line of 8 or 12 cars (and me) strung out behind them. When oncoming traffic makes it impossible to pass them, the only thing that keeps me from morphing into Mr. Exploding Head is my full-face helmet.
But I made it past the rolling roadblockheads on 97, and down to the Columbia River. There I veered east on I-84 and followed the once mighty river, now reduced by the Army Corps of Engineers to a chain of flaccid, but barge-friendly lakes, to Umatilla.
Wind Turbines down by the Columbia
Crossing over into Washington, and blazing across the Palouse, my GPS informed me that I was within a half-days ride of the Canadian border. So I decided to call it a day once I got to Spokane. But my research for this trip hadnt uncovered the fact that there was some sort of huge basketball tournament in town, and every motel room for a hundred miles was booked.
Thus I found myself staying well north of Coeur dAlene, and well beyond where I wanted to end the days journey. Ah well, it would make for an easier 2nd day, I hoped.
Total miles, Day One = 605.2
I'm tryin' ta think, but nuttin' happens!
Red Sox Nation
Joined: Oct 2004
Location: India Wharf
Oddometer: 10,315
I'm in. BTW is the CDR dirt? always thought it was a series of paved roads wondering along the dvide.
Straight ahead and faster -Bo Weaver 1970
"There I was..." -Griffin Niner Three Hotel
"One day closer to a parade..." Jonny Gomes, spring training 2013
Mod Squad
Joined: Aug 2002
Location: Toronto, ON
Oddometer: 57,135
Beautiful ride That's the beauty of a bike, most of the time, you can blow by the highway hogs, mr. RV USA, doing 45 in a 55 zone, with a full paved shoulder, but noooo... he's holding his place..
Keep it comin'
I'm curious to know the range of the 800gs when doing straight highway at about 70mph.
ADV decals, patches & flag? Here
House Ape
Joined: Feb 2003
Location: Ashland, OR, USA
Oddometer: 2,204
And on the second day, the bike got a little dirty.
I was still 200 miles from the border that morning. But the dawn brought clear skies, and the states of Idaho and Montana provided twisty mountain roads. Made me very happy.
I decided to cross over into Canada and get a stamp in my passport to make the start of the ride official.
Canadian border guard: What is your destination in Canada, sir?
Me: Oh, about 20 meters up the road.
That got his attention. So I explained the purpose of my visit, got the stamp, and turned back to the U.S. of A.
American border guard: How long was your visit to Canada, sir?
Me: Oh, about 30 seconds.
Another explanation. Another stamp. Then I was on my way!
At the border
The dirt portion of the trail didnt start for about twenty miles. But once it did, it was suddenly clear to me just how isolated I was going to be for the next 2450 miles or so. All signs of civilization disappeared, and I felt completely cut off from the modern world.
At the start of the dirt.
It was an illusion, of course. I had only traveled about fifteen miles from the nearest town. I had a GPS to help me navigate. I had maps. I had a satellite tracking device. But all of a sudden I felt like Meriwether Lewis on a motorcycle. That was so cool!
The first dirt roads werent that difficult. I knew that this was the easy part of the trail. But I was heartened by how well the bike tackled the few tricky obstacles that I encountered, and how comfortable I felt during the ride. It was a great warm up for the more difficult sections ahead.
Near Glacier N.P.
Red Meadow Lake
That night I ended up in Kalispell. And for Day 3 I was headed back into the mountains towards Helena and Butte. I had no idea how far Id get. But this wasnt a race. Slow and steady. Doh dee doh.
Total miles so far: 935.9
Miles, Day Two: 330.7 (about 100 in the dirt)
I'm tryin' ta think, but nuttin' happens!
House Ape
Joined: Feb 2003
Location: Ashland, OR, USA
Oddometer: 2,204
It's a 2450 mile trail, of which about 80% is dirt (or gravel, sand, mud, etc.)
I'm tryin' ta think, but nuttin' happens!
Look a moose
Joined: Jan 2007
Location: SoCal
Oddometer: 743
Great pic's..
Enjoy the trip, thanks for sharing.
Joined: Mar 2007
Location: Nature Coast, Florida
Oddometer: 3,963
CDR.... Continental Divide Route??
Why isn't it the CDT?
I'm in on this one WW. I would like to ride this trail, ...err, route some time soon.
My Ride Reports
House Ape
Joined: Feb 2003
Location: Ashland, OR, USA
Oddometer: 2,204
I'm tryin' ta think, but nuttin' happens!
The Old Fart
Joined: Aug 2007
Location: Spoke Can, WA
Oddometer: 2,111
I'm following this one!
This is the trip I've wanted to take for the past couple of years. Will be eagerly reading your account. I want to try it on a 650 Dakar, so will be interested in how the 800 GS handles it all.
Dale WU7X
occasional wanderer
Joined: Oct 2006
Location: Central Texas
Oddometer: 838
2000 Suzuki DRZ400S, 2012 Yamaha Super Tenere
My Great Divide Ride 2009
Great Divide Part 2
House Ape
Joined: Feb 2003
Location: Ashland, OR, USA
Oddometer: 2,204
Another beautiful dawn greeted me, and by 7:30 I was on the road, heading for the mountains east of Kalispell. The climb was pleasant, a fine gravel road. But at the ridge the road narrowed to a single-lane jeep track, hemmed in by trees and bushes on either side. It occurred to me that Id have little chance to avoid any wildlife crashing out onto the trail, so I covered the clutch and brakes.
The narrow road
Rounding a curve, I spied a large, dark object sticking out of the undergrowth down the trail a ways. It looked like a big log. But the log (which was considerably larger than any of the trees nearby) suddenly raised its head and looked at me. It was a bear, about 50 yards away! Even if there had been room to turn around, that bear would have been on top of me before I could have gotten half way around. But he (or she) took off into the bushes before I even had half a chance to shit my pants.
It was only a black bear, not a Grizzly. Didn't get a picture, though. Sorry! But I decided then and there not to be doing any solo camping until I got out of bear country.
That bear wasnt the only wildlife to cross my path that morning. I saw two deer, an elk, some grouse, a pheasant and her chicks, and lots and lots of bunny rabbits.
A few miles after the bear encounter I managed to get good and lost. Yes, even with a GPS, I got off track not just once, but twice! And then, a after backtracking several miles to a known point, I regained the trail only to discover that it had been gated off by the Forest Service.
And this is when a GPS is really handy. I just punched in the name of the nearest town (Condon) down in the valley below, and it navigated me by the most direct route down to the highway.
It turned out that I only missed about 6 miles of the actual trail, because it gets routed down onto the highway near there anyway.
But following this trail through the maze of forest roads was trickier than I thought. Forks in the road dont present obvious choices. Each road looks the same, and the one going off in the right direction often turns out to be the wrong choice. Not helping me was the fact that I was traveling in a southerly direction, and my GPS was set up with its map oriented to the north. So every right was really a left and I kept getting turned around. It was only late in the day that I changed the orientation to adhere to my track, and suddenly following the course it gave me was much more intuitive.
Duh. I seem to have to learn everything the hard way.
I stopped for gas in Lincoln, of Unabomber fame, and then rode up and over Stemple Pass. It was the first crossing of the Continental Divide of this trip, and I was to recross it four more times on this day. Four down, twenty three to go.
Stemple Pass
The trail got much more rough and tricky after Stemple. Deep ruts, steep descents over loose rock, pot holes, mud holes, and a few deep gullies across the road that I managed to hit hard enough to make me fear that Id bend a rim. But the bike (and I) came through without a scratch.
It was much steeper than it looks here, and it was much rougher than this in places. But I wasn't stopping for pictures then.
I bypassed a particularly hairy part of the trail at Lava Mtn., but even the bypass gave me some trouble. Piles of deep, fresh gravel had recently been dumped at the top of the bypass, and I have had my share of scary moments in deep gravel. Not this time, though, as the bike rode up and over it with ease if I gave it a little throttle. When in doubt, gas it, a well worn motorcycle aphorism says. The often unsaid second part is: It may not help, but itll sure remove the suspense.
By 3:15 I was within spitting distance of Helena, a good stopping point for the day. But Butte seemed reachable, so I crossed up and over one more range before finding a place for the night.
The next day the trail heads up onto a high plateau, and there would seem to be an opportunity to rack up a few miles. Maybe even reach into Idaho. But its also supposed to feature some of the most scenic parts of the ride, so I may be lured into stopping to take a bunch of photos. Thats OK. As I said, Im in no hurry.
Total miles so far: 1239.4
Miles, Day Three: 303.0
I'm tryin' ta think, but nuttin' happens!
Joined: Jul 2008
Location: PNW
Oddometer: 59
Please post a map of your route!
House Ape
Joined: Feb 2003
Location: Ashland, OR, USA
Oddometer: 2,204
But this might be more helpful, a link to BigDog's GPS track that I used on the ride.
I'm tryin' ta think, but nuttin' happens!
House Ape
Joined: Feb 2003
Location: Ashland, OR, USA
Oddometer: 2,204
Well, Day Four started out more exciting than I had intended. The trail took a brief climb up from Butte over a small range to the southwest before descending steeply down to I-15. But I stopped to take a picture at some point, and forgot to turn off the ABS when I started up again. It was only during that very steep descent that I suddenly realized that I had almost no brakes at all! Only some engine braking and a lot of luck saved my bacon.
I really should have some sort of off-road checklist.
Just south of Butte
After the descent the trail stays on pavement for a while, and follows the Big Hole River. The sweeping curves and Montana's 70 mph speed limit brought out the hooligan in me. Someone ought to come up with a "Montana's River Roads" book. I'd buy it.
The fun didn't stop as I turned south again and started to climb. For about 25 miles the trail winds its way up through aspen forests populated with all sorts of wildlife. I saw elk, a moose, two wolverines, and raptors galore.
Finally I emerged out onto a broad plateau, and after another brief swing eastward onto pavement, I turned south again onto the Bannack road.
The Bannack Road
Bannack was briefly Montana's state capitol during its heyday as a mining town. It's a well-preserved ghost town now, and well worth the 4 mile detour off of the trail.
Farther down the Bannack road I met my first bicyclist. He was slumped over his handlebars as I came up behind him, so I stopped to see if he was OK. He was just resting (I don't blame him!) and it turns out that he came all the way from Switzerland to ride the trail. And his home town is Breitenbach, just down the road from where I used to live when I was a boy! We chatted for a while, and I got the chance to use what little remains of my once fluent Schwyzerdütsch.
About five miles farther I met my second bicyclist. Only this one was sitting alongside the trail next to his wrecked bike and trailer. Seems he had taken a bad spill on the rutted trail (which had been giving me some trouble too), and had pretzeled his front wheel and banged up his knee so bad that he couldn't put any weight on his leg. Even if it hadn't been 30 miles to the nearest town, he wasn't walking out of there.
I asked if there was anything I could do to help, but he said his buddy, who I later passed farther down the trail, was riding to get help.
It took me another hour to ride out to civilization. His buddy wasn't going to get help before nightfall. So once I got back into cell phone territory, I dialed 911 and notified the sheriff. I hope they got him out of there.
Bicycles. You gotta be crazy to ride those dangerous things!
After gassing up in Lima, I started a long, flat section of the trail that took me back into Idaho. It was well groomed and easy to ride, and except for the few sections where they had "improved" the road by dumping piles of deep gravel on it, my biggest problem was just trying to keep from going stupid fast.
East of Lima
Nearing the Idaho Border
That all ended at the Idaho border, where the trail winds its way around the northern edge of the Teton range. About 30 miles of nasty, steep, rutted, and muddy road finally wore me out.
There were no cheap accommodations in the area, so I opted to camp at one of the concession camps in the Teton Nat. Park. Bad idea. Not only did it cost $26.50 for a camp site, but my site was wedged in between a family with lots of noisy small children on one side, and Herr und Frau Bickermeister from Germany on the other. Plus, the place was swarming with mosquitoes.
Campsite in Teton N.P.
So I decided: from now on I'm only camping (if I camp!) in National or State Park camp grounds. My neighbors may not be any more congenial. But it'll be a hell of a lot cheaper!
Total miles so far: 1606.1
Miles, Day Four: 366.0
I'm tryin' ta think, but nuttin' happens!
WoodWorks screwed with this post 10-05-2009 at 10:11 AM
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Originally written on Pro Sports Daily | Last updated 12/25/12
Brooklyn Nets forward Kris Humphries will miss the next two games with an abdominal strain, coach Avery Johnson told reporters Tuesday. Humphries won't face the Boston Celtics on Tuesday afternoon and will skip Wednesday's trip to Milwaukee for a game against the Bucks. Johnson said he will be re-evaluated when the Nets return. The 27-year-old has started 20 of the 25 games he's appeared in this season and has averaged 7.1 points and 7.4 rebounds.
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Auto Repair Orange County
Glen Grabski | 07/02/15
Don't get caught in the heat without a working air conditioner.
Carolyn Hodges | 07/02/15
Mercedes Benz is a car most people would love to own.
Don Sproles | 07/02/15
Regular maintenance on your car is very important.
Chancho Canter | 06/30/15
We have certified technicians who are trained on foreign car repairs.
Craig Rice | 06/28/15
Our service technicians are experienced in both regular engines as well has hybrids.
Almamary Smith | 06/27/15
We will be happy to give you an accurate quote on auto repairs before we start any work. We can take care of the heating and cooling in your car.
Heather Watts | 06/27/15
We have expert mechanics who can take good care of your BMW 3 Series Sedan.
Gail Robinson | 06/27/15
Don't let your oil change go by and drive on dirty oil and clogged filters. Our staff is experienced in bmw 750 repair and bmw 540 repair, as well as all models of Mercedes Benz.
Cindy Ryff | 06/26/15
We can take care of any steering issues for you. When you need vehicle repair on your Smart Car, give us a call.
Carolyn Weber | 06/25/15
Whether you drive a few hundred miles a month or a few thousand miles, we can take care of the maintenance on all your cars.
Heather Hicks | 06/24/15
If the convertible top on your Mercedes SLK is stuck down, we can fix it for you.
Anne Rostan | 06/24/15
We can do interior car repair as well as mechanical car repairs for you. We will be happy to give you a free air conditioning checkup on your BMW 3 Series Coupe.
Alisa Podolski | 06/24/15
We can check your brakes, your steering fluids and balance your tires before you take the family on vacation.
Bruce Smiley | 06/23/15
If the heater in your car isn't working, bring it in for service. Be sure to have us check the air conditioning unit in your car before hot weather hits.
Chris Purcell | 06/22/15
When the motor for your windows goes out, we can replace it for you.
Annamaria Kettner | 06/20/15
Before you go on a road trip, bring your car in so we can check it over for you.
Ellen Ritter | 06/18/15
We are a family owned business that's been in the same location for 35 years.
Ann Jordan | 06/16/15
When you need a complete tuneup on your Mercedes coupe, bring it in to us.
Barb Foote | 06/14/15
Never drive on brakes that feel soft.
Emily Mccoy | 06/14/15
If someone has run into the passenger side door, we can repair or replace it for you.
Emily Pressley | 06/12/15
Transmission service on your BMW, Mercedes, Smart Car or Mini Cooper is easy for us.
Clare Palmer | 06/11/15
If the windshield wipers on your Smart Car are warn out, we can replace them for you.
Caroline Swart | 06/10/15
Oil changes and filter replacements are part of the standard maintenance service we offer. Lucky BMW Z4 Roadster owners know how important regular maintenance is.
Heather Pugh | 06/10/15
We can take care of all the repairs you need on your Mini Cooper or Smart Car.
Anita Mockler | 06/10/15
You don't need to be an auto mechanic when you bring your Mini Cooper in to our auto repair shop. Our mechanics are experts when it comes to 7 series BMW repair.
Daisy Ortiz | 06/08/15
If you need new brakes on your SLK Roadster, call to make an appointment.
Gail Youngmatthews | 06/07/15
We are experts when it comes to repairing German automobiles. If the windows in your BMW 645Ci are stuck, we can repair them for you.
Edgar Parker | 06/05/15
Every car has a different electrical system and we can fix them all.
Ikuyo Pavsek | 06/03/15
When the check engine light goes on, give us a call for an appointment.
Tags |
collision repair Orange County CA
Categories |
auto body repair shops Silverado