text:
An apparatus and method for using ultrasound augmented with microbubbles, thrombolytic drugs or other agents for clot lysis wherein at least one ultrasound transducer generates a plurality of acoustic signals and time, amplitude, phase and frequency modulation of the signals provide more uniform power delivery with fewer gaps in the ultrasound field. Interference patterns from one or multiple transducers are constantly shifted in position. A phased array of transducers may generate a beam that is swept over the area to be treated. In another embodiment, an array of transducers may generate ultrasound at a number of slightly varying frequencies to produce an interference pattern that sweeps in and out through the targeted tissue. A single array may be used to produce both effects simultaneously or separately.
1. An apparatus for generating acoustic fields in an anatomical portion of a human or animal body, comprising:
at least one acoustic transducer for injecting a plurality of acoustic signals into the anatomical portion, and
a signal generator generating said plurality of acoustic signals, said plurality of acoustic signals being characterized by respective frequencies, phases and amplitudes defining acoustic pressure peaks that continually vary temporally and spatially throughout said anatomical portion to avoid continuous standing waves in said anatomical portion.
2. The apparatus of
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11. A method for generating acoustic fields in an anatomical portion of a human or animal body, comprising the steps of:
providing at least one acoustic transducer for injecting a plurality of acoustic signals into the anatomical portion, and
providing a signal generator generating said plurality of acoustic signals, said plurality of acoustic signals being characterized by respective frequencies, phases and amplitudes defining acoustic pressure peaks that continually vary temporally and spatially throughout said anatomical portion to avoid continuous standing waves in said anatomical portion.
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This application claims the benefit of U.S. Provisional Application No. 60/501,000 filed Sep. 8, 2003, the disclosure of which is incorporated herein by reference.
Not applicable.
The present invention relates to an apparatus and method for using ultrasound augmented with microbubbles, thrombolytic drugs or other lysing agents for clot lysis, and in particular to such an apparatus and method using time, phase and frequency modulation of multiple acoustic signals from one or more ultrasound transducers to provide uniform power delivery with fewer gaps in the ultrasound field.
Thrombosis is the development of a blood clot within a blood vessel. A thrombosis can cause serious, even life threatening, conditions due to partial or total blockage of a blood vessel. Various techniques are known for lysing or removal of the clot. These techniques include the injection of various clot dissolving agents.
Ultrasound has been found to be useful in lysing clots and enhancing the effectiveness of a lysing agent, such as a thrombolytic drug.
More recently, microbubbles have been found to be effective as a lysing agent when used in conjunction with ultrasound. Microbubbles are used in the form of a liquid containing stable microspheres of an insoluble, preferably inert, gas. However, conventional techniques are limited in the size and range of the ultrasound field and suffer from gaps in the field and shadowing caused by differential propagation of the ultrasound field through various shapes, compositions and densities of anatomical structures.
U.S. Pat. No. 6,514,220, the disclosure of which is incorporated herein by reference, discloses that the effect of ultrasound irradiation of a portion of a human or animal body is enhanced by operating a portion of the human or animal body as a trapped mode resonator.
The prior art teaches focusing or concentrating ultrasound energy. However, ultrasound energy focused or concentrated at a single location may produce excessive heating or cavitation, particularly when the acoustic field is static. Static acoustic fields may also suffer from insufficient energy levels or gaps in portions of the field.
The present invention overcomes the problems of the prior art by using one or more ultrasound transducers generating a plurality of acoustic signals at similar or different frequencies to produce traveling interference patterns. Also, the frequency, amplitude and phase from the transducers may be modulated so that any interference pattern will be constantly shifting in position, thereby insuring uniform coverage. In one embodiment, a phased array of transducers may generate a beam that is swept over the area to be treated. In another embodiment, an array of transducers may generate ultrasound at a number of slightly varying frequencies to produce an interference pattern that sweeps in and out through the targeted tissue. A single array may be used to produce both effects simultaneously or separately.
At high power, ultrasound causes physical stresses and a temperature increase within the targeted tissue. The amplitude of the excitation voltage may be manipulated to reduce the heating effect. By using a gating circuit, short bursts of ultrasound may be produced so that the average power delivered to the targeted tissue may be reduced while the intensity of the ultrasound may be kept relatively high during the short ultrasound burst. Further, when microbubbles are employed as the lysing agent, the duration between the ultrasound bursts may be adjusted so as to allow even minimal blood flow to replenish the supply of microbubbles at the surface of the clot that will have been ruptured by the ultrasonic action. As noted above, certain embodiments of the invention may use phased arrays of transducers to move an ultrasound beam around the targeted tissue. Likewise, one or more transducers may generate a plurality of varying frequencies to produce interference patterns of traveling waves of ultrasound that sweep through the targeted tissue. A gating circuit may not be required when either of these embodiments or a combination allow the average power lever to be kept low enough in the targeted tissue to avoid overheating.
Variations in the spatial arrangement of the transducers may be used to change the field shape. The transducers may be moved to continually vary the field. Also, the beam from the ultrasound transducers may be designed in such a way that the beam is dispersed at wide angles, obviating the need for an ultrasound transducer to be aimed directly at a clot. Focusing devices or phased array technology may be used to more widely disperse the beam in a "search light sweep" manner. In one embodiment of the present invention, an array of a large number of transducers would have each transducer excited by a slightly different frequency. The resulting pressure waveform would have periodic large peaks with less average power and the pressure peaks would sweep through the targeted tissue in an in and out manner. Also, by sequenced phasing across the array such that each transducer is driven at the same frequency but differing in phase, this phased array could direct the beam through a wide volume of targeted tissue without moving the transducers. By combining these two embodiments, the resulting maxima and minima of the power deposition moving rapidly through all points in the beam while the beam is sweeping the targeted tissue would result in a much better penetration by this focused beam than by a diffused beam.
Known therapeutic ultrasound thrombolysis techniques based on microbubbles, thrombolytic drugs or the like lysing a clot in ultrasound fields are limited in field size and range. Also, ultrasound is absorbed by tissue. Multiple transducers decrease the problems of shadowing and suboptimal energy levels seen with single transducers. The present invention overcomes the limitations of the prior art by using one or more transducers and by frequency, phase and timing modulation of a plurality of acoustic signals to provide more uniform power delivery through traveling waves without the gaps in the fields caused by standing waves. The ultrasound field is manipulated, both temporally and spatially, to maximize both effect and ease of use. Wide application to stroke and problem clots in various applications is expected.
The present invention is unique in that it may be effective in treating ischemic stroke in the human brain where the technique of lysing clots with microbubbles in combination with ultrasound has not been applied. The method and apparatus of the present invention may be used in combination with microbubbles, thrombolytic drugs or other lysing agents.
Interference occurs when two or more ultrasound waves intersect. The waves may be produced directly from an ultrasound transducer or from a reflection from an anatomical structure, such as the surface of the head. Interference may be either constructive or destructive in nature depending upon the relative phase and amplitudes of the combining waves. If the interference is destructive, then when microbubbles are used as the lysing agent, the microbubbles may not expand and contract sufficiently to produce the desired therapeutic effect. The present invention contemplates that the ultrasound frequency and phase from one or more transducers may be modulated so that any interference pattern will be constantly shifting in position, thereby insuring uniform coverage of the targeted anatomical portion of a human or animal body.
In some applications it will be desirable that the ultrasound transducers be designed in such a way that the beam is dispersed at wide angles obviating the need for the ultrasound transducer to be aimed directly at a clot. Precise aiming is less important with the present invention than with older technology. Focusing devices as well as phased array technology allow the beam to be more widely dispersed in a "search light sweep" manner.
Simple variations in transducer arrangement may also be used to change the field shape to match thrombosed arteries, veins, dialysis grafts, and hematomas or collections of thick fluid almost anywhere in the human body. This is illustrated in
If a node of destructive interference occurs and remains in a single spatial location in the target, then the effectiveness of a microbubble's dispersive action upon a blood clot is suppressed in that location. Likewise, constructive interference could produce detrimental foci of increased power deposition. In the method of the present invention, the amplitude, phase, and nominal excitation frequency may all be changed continuously so that destructive interference, created by a plurality of ultrasonic waves or by reflected waves or by a combination of both, will not allow nodes of destructive interference to remain constantly in one position. If two similar ultrasound transducers are operated at slightly different frequencies and the ultrasonic waves so developed are brought together in a medium, then the interference pattern will move, exchanging nodes and anti-nodes at a frequency that is the difference between the two excitation frequencies. This concept can be expanded to a large number of transducers. The objective of the present invention is to use this well known phenomenon to prevent nodes of destructive interference or constructive interference from holding a constant position. In the case of a reflected wave the original wave interferes with a time delayed version of the same wave. However, in a system as complicated as the human head, the relative phases are quite sensitive to slight changes in the operating frequency of the ultrasonic transducer, especially at higher frequencies. Optimum performance is achieved by simultaneously changing the nominal operating frequency while operating multiple transducers at slightly different frequencies. It is preferable for the frequencies of the acoustic waves to be in a range of 500 kHz and above and more preferably in a range from 500 kHz to 2 MHz. The frequencies are selected so as not to resonate and produce standing waves in the anatomical portion being treated.
In order to obtain a more uniform distribution of energy deposition in a volume, certain characteristics related to high versus low frequency acoustic radiation must be considered. First, low frequency acoustic waves, when directed at a small opening in an anatomical structure, tend to be dispersed since the small opening acts similar to a diverging lens because of diffraction. This effect is not significant at higher frequencies where the wavelength is small relative to the scale of the opening. For example, a beam of 40-100 kHz directed at the foramen magnum in the skull will be significantly dispersed, while a beam of 1 MHz will experience little dispersion when passing through the foramen magnum. Second, acoustic waves are attenuated by bone. This effect is much greater for higher frequencies than for lower frequencies. While higher frequencies may experience 90% losses, a beam of 40 kHz may only see a 60% loss. Third, this attenuation effect is true for tissues other than bone. The significance here is that all acoustic waves will be reflected from structures where the speed of transmission of the acoustic wave changes; e.g., from a less dense medium to a more dense medium as when a wave traveling through soft tissue encounters bone. Since lower frequency waves are attenuated to a lesser extent than higher frequencies, a lower frequency wave may be reflected again and again from anatomical structures before it is attenuated to the point where its contribution to the overall energy field is negligible. Such reflections will interfere constructively and destructively, leading to a buildup in energy levels in the anatomical structure with undesirable peaks in the acoustic energy patterns and standing waves. Higher frequency acoustic waves, in contrast, are more likely to attenuate before multiple reflections can occur. The shorter range of such high frequency waves therefore decreases the uncertainty associated with predicting and controlling the levels of acoustic energy in the anatomical structure. In particular, standing waves may be avoided more easily. The drawback to the use of higher frequencies is the losses due to the higher attenuation compared to lower frequencies. The losses can be overcome by using multiple transducers that are spatially distributed and where the frequency, amplitude and phase of the acoustic signals from each transducer are controlled to produce a more uniform acoustic energy field in the anatomical structure at therapeutically effective levels.
Various frequencies and combinations of frequencies may be desirable in particular circumstances to both avoid standing waves with excessively concentrated energy deposition in particular locations and to provide more uniform distribution of the energy at therapeutic levels. For example, lower frequency acoustic waves, such as 40 kHz, may be better dispersed by refraction of the beam when directed through a small opening in a bone structure, such as the foramen magnum in the skull. The lower frequency provides longer range and better coverage than higher frequencies. In relation to the skull in particular, lower frequencies also pass through bone more efficiently than higher frequencies. In general, acoustic waves at higher frequencies penetrate less well, degrade faster, and are much shorter than lower frequency waves; together these characteristics of higher frequency waves avoid a problem of low frequency waves that may match the scale of anatomical structures and thereby tend to form detrimental large standing waves in such anatomical structures. Also, higher frequencies do not disperse to the same extent as lower frequencies and may therefore be more effective as a straight beam, either aimed at a target or swept through a range of vectors to cover a volume. As discussed above, higher frequencies, above 500 kHz and particularly between 500 kHz and 2 MHz, are helpful in avoiding unanticipated peaks in the energy deposition pattern and standing waves. Combinations of frequencies from spatially dispersed transducers may be employed to effectively treat complex structures. An example would be the combination of a 40 kHz transducer at the back of the skull along with a pair of 1 MHz transducers at the sides of the skull as shown in FIGS. 1A-C and 7A-D. Another example would be a linear array of transducers for treating veins in an extremity.
As shown in
Ultrasound is absorbed by tissue and at high power causes a temperature increase within the tissue. The amplitude of the excitation voltage may be manipulated to reduce the heating effect. By using the gating circuit of the amplifier and gate 15, short bursts of ultrasound may be produced so that the average power delivered to the targeted tissue may be reduced while the intensity of the ultrasound may be kept relatively high during the short ultrasound burst. It is known that ultrasound will rupture and destroy microbubbles in the process of clot lysis. This requires repeated delivery of microbubbles for continued lytic effect. The duration between the ultrasound bursts may be adjusted so as to allow even minimal blood flow to replenish the supply of microbubbles at the surface of the clot that will have been ruptured by the ultrasonic action. Also, as noted above, certain embodiments of the invention may use phased arrays of transducers to move an ultrasound beam around the targeted tissue. Likewise, an array employing varying frequencies to produce interference patterns of traveling waves of ultrasound that move through the targeted tissue. The patterns of ultrasound generated by these embodiments may also be used to allowed repeated delivery and replenishment of microbubbles.
Many ultrasonic transducers emit ultrasound into a focused columnar beam. In such a design, the transducer would have to be directed at the location of the clot, which in turn could have to first be located by other means. The present invention would use dispersive elements when the location of the clot was unknown. However, it is not intended to exclude from the scope of the present invention the use of transducers that emit ultrasound into a columnar beam if the location of the clot is known. Furthermore, in certain embodiments of the present invention, a phased array of transducers may be employed to produce a beam that can be aimed by appropriate selection of the respective phases of the acoustic signals. Such a beam may be employed to sweep the area to be treated or can be directed to the location of a clot.
Data using a human skull in a water bath and hydrophone mapping show ultrasound delivery through the foramen magnum using 20 to 80 KHz performs very well (30% of foramen magnum levels) all the way to a point 1 cm above the anterior clinoids. It is still present at the anterior margin of the anterior fossa (18 to 20 cm range) at reduced levels. At the anterior clinoids' 12 to 14 cm range the power levels are nearly equivalent to levels at 5 to 7 cm range through the temporal approach. Shadowing occurs along the inferior aspects of the anterior fossa, which are well filled in by temporal transducers. The shadows posterior to the petrus pyramids when using the temporal approach are well filled in by the foramen magnum transducer. Good diffusing of the beam through the foramen along with good reflections from various structures fill much more of the skull than a linear beam would suggest. Ultrasound diffusion makes aiming the beam unnecessary. With reference to
Moreover, we have experimentally shown that by changing the frequency about 10% up or down from the primary frequency of 40 KHz, the nodes and anodes are swept completely across every particular point in the beam. This is about half of the change we anticipated and is probably due to the multiple harmonics our current transducers produce. This completely covers the targeted tissue and negates the problem of shadowed areas produced by the longer wavelength that is required to get the diffusing refraction of the beam through the foramen magnum.
Frequency agile and interval agile combinations of pulsed wave (each transducer firing in 2 to 20% of the time cycle) ultrasound can be sequenced to avoid mutual interference and completely fill the skull with therapeutic levels of the ultrasound required to lyse a clot with microbubbles, thrombolytic drugs or other lysing agents.
The entire basilar artery and upper portions of the vertebral arteries can now be added to the coverage of the internal carotids, middle cerebrals, anterior cerebrals, and Circle of Willis previously covered with 1 MHz temporal transducers. This is important due to the high mortality of basilar artery strokes and the absence of any good therapy for them.
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Cranberry and Apple Betty with Hard Sauce
Serves: 8
These ingredients are:
Vegetarian Corn-free Egg-free Peanut-free Soy-free Tree nut-free
A Betty is a traditional American dessert made with fruit and topped with breadcrumbs, in lieu of a more common crust. In this recipe, we've replaced with the breadcrumbs with oats.
- 2 cups butter, divided, plus extra for pan Add to list
- 4 Golden Delicious, Fuji or Granny Smith apples - peeled, quartered, cored and thickly sliced Add to list
- 1 lemon, zested Add to list
- 1 1/2 pounds fresh cranberries, divided Add to list
- 1 1/2 cups granulated sugar Add to list
- 3/4 cup rolled oats Add to list
- 3/4 cup unbleached flour Add to list
- 3/4 cup dark brown sugar Add to list
- 1 1/2 cups unsalted butter Add to list
- 3/4 cup powdered sugar Add to list
- 2 tablespoons cognac, brandy or whiskey Add to list
- 1/2 teaspoon vanilla extract Add to list
Preheat oven to 375°F. Butter a 9-inch square baking dish. Place apples and lemon zest in the dish and set aside.
Combine 3/4 pound cranberries with granulated sugar in a saucepan. Cook over medium heat until cranberries begin to pop. Remove from the heat and pour over sliced apples and lemon zest. Blend gently with a wooden spoon.
Combine oats, flour and brown sugar in a bowl. Cut 1/2 cup butter into the mixture using two forks, a pastry cutter or your fingers. The mixture should resemble pea-sized pieces. Toss in remaining 3/4 pound cranberries. Sprinkle on top of the filling.
Bake for 45 to 50 minutes, or until topping is browned and filling is bubbling. Remove and allow to cool until slightly warm.
Cream remaining 1 1/2 cups butter and powdered sugar in an electric mixing bowl on medium speed. Add liquor and vanilla. Blend thoroughly. Keep at room temperature, covered, until ready to use.
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On this day to remember a great man who spoke out against injustice and for the necessity of fairness and civil liberty, it's hard to think of a more fitting opportunity to introduce a new video by another outspoken voice of the black community, Gil Scott-Heron. Now at 60, the poet and songwriter is asRead more…
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KEXP AND THE UWKEXP is an
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iTunes and KEXPYou can now find KEXP under "Eclectic" in iTunes after the demise of the "Public" category, to better represent the diversity of our daytime variety shows and numerous specialty programs.
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« 3.5 Years | The Moroccan missionary explusions »
February 19, 2010
Sorry for the long absence. I have been fighting a number of business battles over the past two months, which have been terribly time consuming.
Posted by The Lounsbury at February 19, 2010 04:00 PM
Filed Under: Blog Notes - Admin
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Any thoughts on the Gaddafi-Swiss row? Certainly inspires confidence in doing business with The Guide, no?
Posted by: Djuha at February 26, 2010 10:57 AM
Yes, but when I get off planes, in transit at the moment.
Posted by: Lounsbury at February 26, 2010 11:01 PM


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Cypress, TX, USA < change city >
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Spring Chateau
Spring, TX 77388, USA
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6 ratings, 6 reviews, 15 weddings
I attended a wedding at Spring Chateau in August 2014. Overall it was a lovely ev...
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1016 FM 1463 Rd
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5 ratings, 5 reviews, 10 weddings
Kalyn and Daniel are a great couple and we regret that they feel the way they do ...
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4 ratings, 4 reviews, 16 weddings
Jennifer O'Keefe is wonderful! The Westlake is a hidden gem in Houston! I definit...
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1111 Pierce St
Houston, TX, USA
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5 ratings, 4 reviews, 20 weddings
I'm giving them two stars - trust me, I'm tempted to give them one star - but we ...
The Woodlands Resort & C...
2301 North Millbend Drive
The Woodlands, TX 77380, United States
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3 ratings, 3 reviews, 24 weddings
Very beautiful landscape. Beautiful big deck available for the ceremony. The los...
Safari Texas Ranch
11627 FM 1464 Rd
Richmond, TX, United States
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2 ratings, 3 reviews, 36 weddings
When I went to set up in the morning, the hall was filled with misquitos, there w...
Ashton Gardens
21919 Inverness Forest Boulevard
Houston, TX 77073, United States
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4 ratings, 3 reviews, 30 weddings
This place speaks for itself! Laura did a fabulous job with the set up and return...
St Anne's Catholic Church
2140 Westheimer Rd
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3 ratings, 3 reviews, 14 weddings
The most beautiful Cathollic church in Houston. The rules to marry in this churc...
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Church is beautiful but the organist almost ruined the wedding with her bad attitude
River Oaks Garden Club
2503 Westheimer Rd
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This place is charming. Everyone loved it, and because it is so beautiful you rea...


text:
Realistic time frame for Fermi (not happy with 5870)
Hello fellow members!
I was wondering if any of you could give me a relative time frame for fermi's release. Also what is the estimated price range? I am in a bit of a pickle here. Currently I own a 5870 and I am very unhappy with it. Powerful Hardware no question about that, unfortunately hardware is only half of the equation while drivers are the other half and this is where ATI fails. I plan to sell this Card before ATI lowers the price when fermi comes out.
This is my first time using ATI products, so prior to owning them I had heard all about the numerous driver problems etc...When I purchased this card many had claimed at this point that the ATI drivers were much improved and no longer had the problems that plagued there past drivers.
In my personal experience I find this to be untrue. Ati is constantly releasing drivers fixs(hot fix) and usually it fixes one thing and breaks 3 others. I am sick and tired of this and it's inability to force AA consistently, Vsync issue etc... while Nvidia drivers never had a problem in this area. Only after actually owning/testing the ATI hardware does it make me appreciate the Nvidia Drivers even more. My 6800+8800GTX was a dream to use, compared to my 5870. CCC is poorly designed period. This is not a question of getting used to ATI's different approach to driver interface. I learned all the ins and outs of CCC and still came away very unimpressed. Nvidia control panel is simplistic and straight forward. If it was not for ATI TOOLS I would have already lost it.
Anyways I am borrowing my brothers GTX260 for the time being. I want to be able to reserve or make a pre-order on the fermi card when retailers have the available information. I need to have an idea of how much cash I need to put aside. Right Now I have $500-CAN
Re: Realitic time frame for Fermi(not happy with 5870)
Re: Realitic time frame for Fermi(not happy with 5870)
Re: Realitic time frame for Fermi(not happy with 5870)
What a Pain in the ASS ATI's CCC has been. All I have gotten from the ATI community(rage3d) was weak excuses such as the game was never ment to have AA, the developer is Nvidia biased etc...with CCC you are always guessing. Also profiles are still a problem after all these years.
Re: Realitic time frame for Fermi(not happy with 5870)
Have you tried renaming the exe:s to UT3 or alt-tabbing out of the game and then enable AA? Which games are you having problems with?
EDIT: Forgot to mention this earlier - running d3doverrider seems to fix most of the vsync issues with ati cards.
Re: Realitic time frame for Fermi(not happy with 5870)
CCC is easier to use than NV control panel....the only, and I mean only thing better about nV,....is nHancer and it's ability to manipulate profiles which has abso****inglutely nothing to do with nVidia.
Re: Realitic time frame for Fermi(not happy with 5870)
Agreed, as I said before the 5870 is very powerful hardware no question about that. What good is this power if I can't get certain elements of it to function properly. I am tired of having to wait and see if ATI fixes it in there next driver when I can use a GTX 260 and have it all work right off the bat.
AS for Vsnyc I am aware that the 2 current options are to use; the D3Doverider from rivatuner or use ATI TOOLS which also forces Vsync.
Ultimately I think it's only fair for people to know that when moving over to ATI do not expect the same driver quality that you were getting from Nvidia. Overall for most new games the 5870 does function well, and ATI is quick to patch bugs etc... Just I have had to many issues that I expect to work since Nvidia seems not to be having those problems.
Re: Realitic time frame for Fermi(not happy with 5870)
Since i own two of these HD5870 i played only one game Mass Effect 2 with no AA, that's how good gaming experience is with them. By the time they released Crossfire profile for Mass Effect 2 a game was like two months old and already beat it. Bottom line -> absolute garbage.
Re: Realitic time frame for Fermi(not happy with 5870)
Btw. nvidia didn't have an sli profile for ME2 either when it launched and there was a lot of people who had problems with SLI AA(nhancer took care of it though).
Re: Realitic time frame for Fermi(not happy with 5870)
Re: Realitic time frame for Fermi(not happy with 5870)
Also you'd have to be freaking lazy not to rename one little shortcut to UT3.exe instead of playing the game without AA.
Re: Realitic time frame for Fermi(not happy with 5870)
In regards to AA "not working" for Nvidia guys who have migrated to ATI...
AA works in most games just fine for ATI, but there's a certain way you have to set your options in the CCC. It doesn't work like the Nvidia CP where you can simply force it from the control panel in every application. ATI and Nvidia are two entirely separate companies with separate applications/implementations for graphics settings.
If you want to switch camps, that's fine, as Nvidia has some nice drivers and products. I'm just giving you the heads up that it's probably some settings that you have wrong. I've very rarely had an issue with ATI not running AA in a game or not being able to get vsync to work (no vsync is a side effect from forcing AA in the CCC when it's not supposed to be, by the way.)
In all fairness, it's not entirely the user's fault. ATI should have some sort of readme or instruction file in the driver set that explains how their AA works.
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- Wed, Apr 15, 2015
- Heaven
C . S. Lewis, The Romantic Rationalist, and Longing for the New Earth
In Mere Christianity Lewis lamented that we haven't been trained to want Heaven: "Our whole education tends to fix our minds on this world. …when the real want for Heaven is present in us, we do not recognize it. Most people, if they had really learned to look into their own hearts, would know that they do want, and want acutely, something that cannot be had in this world."


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Harold Brantley #90
The Latest: Coach's Corner: Craig Kuligowski — 4/6/2015
PowerMizzou.com is talking to the Tiger assistant coaches to get spring breakdowns of each position. Today, our chat with defensive line coach Craig Kuligowski.[details]


text:
Here's my simple advice. Open a Labatt Blue Light, sit back, relax & enjoy the last 4-7 games of NHL Hockey until October. Do not think about how The Sabres could have beaten Philadelphia, or how both Chicago & Philly have players we wish we still had. Those things will only make you angry.
When you're watching The Stanley Cup Finals with a group of Sabres fans, conversation will inevitably turn towards the question, 'Why aren't we here?' I seriously mean it, don't think about it! If you spend these next two weeks thinking about Whether the Sabres could get Eric Staal for Tim Connolly and Toni Lydman, you're ruining the experience. There is plenty of time between now and October to worry about our beloved Sabres.
There are two things I guarantee. The Sabres will not win the Cup this year, no matter how much you whine about Darcy Regier or Jason Pominville. #2, this series is going to be AWESOME. By awesome, I mean violent. There will also be some scoring. Wow, I'm such a fortune teller! No shit?, there's going to be goals in a hockey game? Tell me something I don't know.
Here's something you may not know. If Chicago loses, Marian Hossa will watch the opposing team skate around the rink with the big silver cup for the 3rd year in a row. (2008 – Pittsburgh, 2009 – Detroit). Ouch!
My suggestion for enjoying the Cup Finals is to go one of two ways:
1) Pick a team and root for them. Whether it's Philly or Chicago, I don't care. Sports are more fun when you're rooting for someone to win. If you can, forget about how much you hate Philadelphia. If you can't, then root for Chicago.
2) Pick a few players to dissect. Watch every shift Patrick Kane takes. Notice his moves, study him, see how often he takes a hit, gives a hit, does he shoot more wristers, slappers, snappers? Become an expert. You can do this with a single player, one guy from each team, one player on each line, multiple players, goalies. The more players you choose, the less in depth you can go into about each guy.
My choice would be Pronger. If you watch Pronger you're going to notice how much respect he gets from opposing players. Most forwards know they're getting a one-way ticket on the pain-train if they mess with Pronger, so he actually has to do very little checking. Much of his success comes from reputation. I expect Dustin Byfuglien to give Pronger a good challenge 'in the paint', (in front of the net).
My next choice to watch is Jonathan Toews (Taves). He has a boat load of assists (19) in the playoffs so far to go along with 7 goals. I haven't gotten to see too many Chicago games this playoffs and I intend on seeing every game of the finals, just to see how good Jonathan Toews does.
All right, Sabres fans. If you are completely over Briere and Campbell then I see no evil in rooting for them to succeed. The Sabres chose not to keep these players and they went to other teams. Not their fault. If you're still bitter then simply ignore them and try to focus on the other players. It's like not talking to your ex-girlfriend until you are COMPLETELY over her. If you contact her too soon, you're just going to embarrass yourself. There will be one guy at your Stanley Cup Party who turns it into a "Briere, Campbell, whine-fest". DON'T BE THAT GUY
For now, accept what we can't change, put the Blue & Gold on the back burner for two weeks and Enjoy the Stanley Cup Finals. It's going to be good. I promise.


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What do guys really want for their birthday?
So my boyfriend/fiance is turning 23 next week. He says it is not a special day or anything. But I'm still planning on things to make it special. I... Show More
Most Helpful Opinion
I'm more of a beach than a boat person, so I'd be cool with the restaurant by the beach. But they're both good idea's. And I'm sure he's going to notice how good of a job you do/did/whatever, you know what I mean. And I'm a person who likes to go to events for my birthday or sometime after even, like concerts and shows, things like that. Maybe you could look into something like that.
Thank you Nash :) Yah, I might take him to the beach restaurant instead because I do recall him saying he gets sea sick. But the events idea is really good. I'll have to look into that and see if there are any good ones. Thanks again :)
Light-bulb! lol, like it just went off in my head, haha - another idea - you could do things like wake up early and set the coffee maker for him of something relative like that. Little things, you know, you got to use your imagination on that one, and best of luck!
I would try to get him to take care of whatever he needs to take care of at work and just reschedule the birthday party for another weekend if it's getting like that. and just let him know that you care, so it's tough to just sit back and not do anything about the birthday. This isn't something that can't be moved around or whatever, he doesn't have to make a mountain out of a ant-hill.
What Guys Said 3
i'd delete his war of warcraft account given him the gift of life.
Hooters: beer and boobs.
Then because he's drunk and horny, give him a free pass to all of your rides.
Vola! happiness.
Haha I agree about WOW! That game takes up half of life! lol
Hooters? Sounds good. But they don't have it here.:(
What Girls Said 0
Be the first girl to share an opinion and earn 1 extra Xper Point!
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I was looking over Wyoming's schedule and as much as I like LeBlanc and Martinez there is just no way to justify picking them unless they are still around in the 11-15th round. Do you have any guesses as to the decrease in duals this year ?
Looked at some schedules and saw the ''Disney Duals'' are also the ''Florida Duals'' and have , so far , Columbia ,UTC,Gardner-Webb, IU, and the Citadel . My guess is Florida is trying to show at least some token interest in collegiate wrestling .
I am jonesing !! Need to make a draft pick-!!!
As per our last conversation I truly believe you should go ahead and count MOST of the tournaments from last year (IF NOT ALL) simply because the kids are wrestling Div 1 opponents .
Count them but with NO bonus points .I can remember when the MSU had Clum,Escobedo,Hernandez,and Gomez-now it is pretty much a joke -but if your stud 141 breaks his leg the tournament will count rather you like it or not .
How could you count Binghamton and NOT count NCState ?
The big tourneys are the money ones anyway .
Just my 2 cents .
JensenS, High School: Four-time freestyle All-American...won the Freestyle Triple Crown in 2007...placed second at the national meet as a junior, third as a sophomore and fourth as a senior...was undefeated through his senior year, including winning the five counties tournament, and was ranked No.1 heading into the California State Tournament...lost two matches at the state tournament (by a combined total of three points) due to injury and placed fifth...won California State Freestyle Championship both his junior and senior seasons...was 2005 California Junior High Folkstyle State Champion ...
Loder was 32-5 last year -lost to the usual studs but kicked ass everywhere else-his pedigree is outstanding .
I was just curious if you've ever seen Ryan Loder from UNI in action ? His resume is great and he won nearly every tournament you could win in high school and finished 32-5 last year as a freshman. I am already looking for a few dark horses .
Later , Russ
If you have some free time check out on Flo-Eric Roach/Hull-145-the match was boring as Hull stalled from the middle of the second on;but at about the 1/2 way mark Roach uses a front headlock to a side cradle and puts the kid right on his back-a TRUE thing of beauty but the kid screamed injury so they stopped the match-then Hull gave up-final was 6-3 but Roach owned the kid-I mention this as an effiecanianto you'd appreciate the move -he is also going to IU instead of Purdue -3 x State and 2x national Folkstyle champion .
JensenS ,
I posted Michigan's schedule under OSU's -I did not know how to move it and was wondering if you would help me out ?
Michigan has a great Fantasy schedule if you look at it .
I want to start by saying I look forward to your predictions and am amazed at your wrestling knowledge ; that being said -IS THERE ANY WAY TO STOP ALL THESE PREDICTIONS FROM INDIVIDUALS WITH TINY GENITALIA AND HUMONGOUS EGOS ???
Thanks ,
Barlowe knocked off Trice
Just made a trade with Mat Eater . Needs your approval .
Great job -I was afraid Tim would back out -good luck -I wanted to pop his cherry but just couldn't do it -great trade all around .
you forgot to move Pucillo onto my roster and Askren onto Mojo's -also next week(Friday) I will be sending Conroy back to MatEater as he wanted Triggas for a few weeks and I wanted Conroy for one -it will be 3 weeks tomorrow .No hurry save for Pucillo .
Just watched the KSU/Purdue match on Flo-no throws -2 quick singles and 2 sloppy cradles -I mean freshman level -but they got Mallie 3 and 3 . Rode Salazar like a mule .
I traded Jones and Bailey to Goph for Biondo and Ciasulli. A 4 and 21 for a 10 and 18. Pending your approval when can we use them ??
Hate to bother you but you did not put Cococococozozozo on my roster after my trade with MatEater .He now has Nemec.thanks .
JensenS -MOJO asked me to trade him Orozco for Jones so I did -he knows Jones is 1-4 lifetime against Drury and is having a bad year -Orozco should win the Pac 10-
Now I need to find a conference champ at 97 -Lapotsky places 3rd on a good day .
4. Craig Kelliher (Central Michigan) Dec Pat Bradshaw 7-6 2-2-I don't care about this trade because lost can't beat me -but this is ridiculous
Congrats on Martinez-he has 2 matches this week -you may want to update your lineup.
Made a trade with Mateater -Triggas for Conroy .


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Passion Pit plays with childlike enthusiasm
There were more than a few moments during Passion Pit's show Thursday at the Riverside Theater when a jaundiced observer could wonder if the music was actually aimed at children.
Sure, the Massachusetts quintet began its performance around 10 p.m., but frontman Michael Angelakos exuded the manic energy of a kid who, just before bedtime, had gorged on all the candy he got trick-or-treating the previous night. »Read Full Article(2)
Bieber reminds us that he still makes music
Justin Bieber, 19, has had a problematic PR year, to say the least, with damning headlines practically on a weekly basis. Bieber abandoned his monkey in Germany! Bieber allegedly visited a brothel in Brazil! Bieber urinated in a restaurant mop bucket and cussed out a picture of Bill Clinton!
But he's trying to end his year reminding people he's actually a musician with an iTunes exclusive album, "Journals." Released Monday and reportedly only available as a bundle of songs for two weeks, "Journals" features 10 songs that were previously released on a weekly basis starting in October as part of his recent Music Monday series, plus five brand new tunes. »Read Full Article(11)
Top of the Charts: The top Christmas hits
As Christmas quickly approaches, the airwaves - and stores - are filled with the sounds of the season. So, we'll take a step away for the Hot 100 for a week to take a close look at Billboard's Holiday 100. You can find the full list of the year's biggest Christmas hits here, but first let's take a closer look at the top five below. It's a surprising mix of big stars, reality TV champions and old favorites. Strap on your jingle bells and sing along!
No. 5 Holiday Hit »Read Full Blog Post
On Tap for Today: Christmas lights and Festivus celebrations
On the Monday before a big holiday don't we all feel a little like squirmy gradeschoolers who can't wait for Christmas Eve?
Here are a couple ideas for keeping spirits bright: »Read Full Blog Post(1)


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41 year old woman | Saint Paul, MN, USA | Seeking men 37-45 within 30 miles
Looking for friendship and fun and hopefully more!!!
I am a caring, honest and easy going person. I am not a materialistic person at all. I enjoy dancing, music (especially live bands). I like gardening, fishing and anything outdoors in the summer time. I would like to meet someone that likes getting out and enjoying life. Also someone that is easy going and down to earth. I have two beautiful daughter's whom I enjoy spending time with and who are the most important people in my life. I enjoy traveling, long walks, dining out and barbecues and spending an evening at home watching a movie.
Camping , Dining out , Fishing/Hunting , Gardening/Landscaping , Hobbies and crafts , Movies/Videos , Music and concerts , Exploring new areas , Nightclubs/Dancing , Religion/Spiritual , Travel/Sightseeing
Dancing, Other types of exercise, Walking / Hiking
I like Dogs
I love being on the lake or rivers in the summer, anywhere in Minnesota. I have enjoyed traveling also to California, Mexico and Florida in the winter.
Love all music. I Especially love country music.
Enjoy movies, live bands, dancing. I also enjoy the outdoors more so in the summertime.
I don't actually read a whole lot, a magazine here and there.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'5" (165cms)
|5'8" (172cms) to 6'2" (187cms)
|Body type:
|About average
|About average, Athletic and toned
|Blue, Brown, Green, Hazel
|Dark brown
|No preference
|No Way
|Occasionally, Yes, but trying to quit
|Social Drinker
|No preference
|Other profession
|No preference
|I'll tell you later
|No preference
|Never Married
|Never Married, Widow / Widower, Divorced
|Have kids:
|Yes, and they live at home (2)
|Yes, and they sometimes live at home, No, Yes, and they live away from home, Yes, and they live at home
|Wants kids:
|No, No, but it's OK if my partner has kids
|White / Caucasian
|White / Caucasian
|Christian / Other
|Christian / Other
|Some college
|No preference


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Take a quick walk around the block of stores at Evergreen Plaza in Orchards, and you may see the sprouts of a new — if somewhat controversial — industry.
Within view of the shopping center at Northeast 117th Avenue and Fourth Plain Boulevard are three "head shops," stores specializing in pipes and other marijuana paraphernalia. And within about a mile of the plaza, at least three people have applied for marijuana retail licenses, while a handful of others have applied for growing or processing licenses.
Why the area seems to be turning into a marijuana mecca is anybody's guess, beyond the fact that at least portions of it meet the state guidelines that say stores must be more than 1,000 feet from a school, public park, transit center, library, child care center, playground and arcade.
But what's more noteworthy is the lack of strong outcry against it by the community.
"People in my church haven't really said anything about it, and they usually do speak up — especially about roads and other things going on in the area," said Kathy Neary, president of the Maple Tree Neighborhood Association and pastor of Orchards United Methodist Church. "I think people are waiting to see what happens."
Some have mentioned the potential new pot stores in neighborhood meetings, but even that has been a lot less than you'd expect, she said.
"Somebody at our last meeting asked about the new laws," Neary said. "And there was concern about the impact, and how much the Clark County Sheriff's Department will be policing the area. But I think the concern is more that we have enough deputies to cover each store (and the potential for break-ins or other criminal activity)."
Cmdr. Mike Cooke of the Clark-Vancouver Regional Drug Task Force said he's concerned about legalized marijuana — is, in fact, opposed to it altogether. Some studies in Los Angeles have shown issues with increased crime around medical marijuana dispensaries, he said.
"From a law enforcement point of view, it remains to be seen whether the marijuana business will increase crime here," Cooke said.
Mostly, though, residents seem to be just watching the situation.
Christie BrownSilva, president of the Sifton Neighborhood Association, said she's heard a mix of comments from her community, but it hasn't been overwhelmingly strong either in support of or opposition to the marijuana industry.
"It's a little bit of everything," BrownSilva said. "We have a pretty large neighborhood, so you get a variety of opinions. But the thing is that if (potential stores) go through the process, and they get approved, they're going to be a part of our Neighborhood Association, so we have to be careful not to alienate anyone."
Economic boon?
Daniel Pool, a manager at Smoke 'N' Pipe, a paraphernalia store at 12113 N.E. Fourth Plain Blvd., Suite C., said he thinks a retail marijuana store or two would be good for the business economy of the area — especially for the stores that are already there.
Last year's legalization of possession in Washington didn't increase sales at his store significantly, but he said he hopes that will change once people are able to buy the product legally.
"Business fluctuates up and down," Pool said. "There are some months when we do really well, and others where we think we might have to lay a few people off. What I assume will happen is, once (marijuana) is in the stores, then we'll see a big upswing in business. My personal opinion is, I think Vancouver will grow exponentially because of this."
And that growth will spread beyond the array of head shops, he added.
"If they have the amount, the number of people going through here, that they anticipate, there will be lots of jobs," Pool said. "The people coming over here will use our gas stations, they'll buy pipes and utensils from us, they'll buy food, maybe they'll even stay in one of our hotels. That will help everybody."
J.S., one of the marijuana retail license applicants in the area, agrees that if the process can move past moratoriums and bans set up by Clark County commissioners, it will help create more jobs.
The woman, who asked that her name not be used until and if her license is approved, applied in both Orchards, which falls in Clark County's jurisdiction, and in Vancouver, which is under city rules that appear to be lining up with state laws.
"We'll see what happens, but I have higher hopes for the city of Vancouver being more reasonable about this," J.S. said. "But yes, it will create jobs. In an actual shop, you have maybe four employees, but there are all these ancillary jobs. Security workers, producers, other niche industries that will pop up."
And even Neary said the people in her area would be happy to see that happen.
"I think we could use more robust business in the area," Neary said. "The idea that it may be your local pot dealer, I don't know. But we could certainly use the business."
She also thinks pot is less of a concern for the area than alcohol.
"I think if we were as concerned about alcohol consumption, we could do a lot more for public safety," Neary said. "I'm not really concerned about (pot), personally."
The businesses that crop up also don't have to be aimed at the stereotypical tie-dye-wearing, Hacky-Sack-playing crowd.
J.S. said her plan is to do something more upscale and boutique-like, with a wide array of products and a separate area specifically for medical users.
"My personal plan is to do something really nice, like a sort of European model," J.S. said. "Something different than the other stores out there. I want you to come in and see 100 strains of marijuana, each with its own properties. And when you come in, you can be educated and get exactly what you want."


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Mana Khemia: Alchemists of Al-Revis
Mana Khemia: Alchemists of Al-Revis Cheats & Codes
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Bonus Dungeon
There's a place called the Old School House in the game, and it's got an area within it that's closed the first time you access it. After beating the game once in its entirety, you can revisit this area by loading up an older save. You can use a teleporter in the now-open closed area to access this bonus dungeon.
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Game Details
Published by: NIS
Developed by: Gust
Genre: RPG
Release Date:
United States: March 31, 2008
Japan: June 21, 2007
E10+ for Everyone 10 and older : Language, Mild Fantasy Violence, Mild Suggestive Themes
Also Available On: PSP
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Putting the icons in place. When you mouse over the circle will fade to solid with the images being white. Would LOVE any feedback. What are your thoughts on that yellow...Is it too light to read?
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I would love to see some comparisons in different calibers. In .380 the DPX went deeper than the DT Gold Dot in a wetpack test.
This is a discussion on Double Tap or DPX? within the Defensive Ammunition & Ballistics forums, part of the Defensive Carry Discussions category; I'm thinking of changing from Speer Gold Dot ammo to Double Tap or DPX in my 9mm, 357 Sig and .45 ACP. Both brands appear ...
I'm thinking of changing from Speer Gold Dot ammo to Double Tap or DPX in my 9mm, 357 Sig and .45 ACP. Both brands appear to be highly regarded. Which do you guys reccommend and why?
I would love to see some comparisons in different calibers. In .380 the DPX went deeper than the DT Gold Dot in a wetpack test.
Is Double Tap available is stores or just via mail order? I've not seen it or even heard of it until recently.
Double tap is a very small ammo manufacturer. There quality control is top notch, and excellent customer service. There products are only available online, and will probably be that way for the foreseeable future.
Gun control is hitting what you aim at...
CorBon's a relatively small manufacturer, but with a big manufacturer's presence. They have good-quality stuff. DoubleTap's a very small manufacturer that also has good-quality stuff. CorBon's recognized; mentioning DoubleTap often draws a blank stare. CorBon's available at the corner gun store, whereas DoubleTap's a special order thing.
I carry DoubleTap 9mm JHP Gold Dot 124gr +P. Bar none, it's the most reliable round I have found for my CZ P01 pistols. Nicely, it also performs very well, both penetrating and expanding sufficiently for my goals. Went through a large number of different rounds, when evaluating the correct match, for this gun. Next in line, in terms of reliability, was the Federal Hydrashok Tactical 9mm JHP 124gr +P+, but the DoubleTaps are smoother and have better round-to-round consistency in potency and cycling.
Have shot a half dozen different DT rounds. They all perform equally well, are as reliable and smooth-cycling.
Unless something better comes along, I won't have anything else.
My goals, more or less: Above 400 ft-lbs muzzle energy; above 1200 fps; decently reliable expansion; exceedingly reliable feeding in my specific carry guns. Not many options exist for ammo that exceeds the 400/1200 threshold. I found only two that are roughly that but feed so exceptionally well. Of those two, I've carried both, but the DT's greatly surpass the Federals for power and expansion (in my basic tests).
Your best weapon is your brain. Don't leave home without it.
Thoughts: Justifiable self defense (A.O.J.).
Explain: How does disarming victims reduce the number of victims?
Reason over Force: Why the Gun is Civilization (Marko Kloos).
Thanks for the input! I will probably stick with the Speer Gold Dot or go to the DPX. I will probably be cost prohibitive to ship Double Tap up here to Alaska. Heavy coats are usually worn 4-6 months a year. Is the DPX penetration much better than the Gold Dot?
Keep in mind that the DPX only comes in lighter bullet weights. Because copper is lighter than lead you can only get so much copper in there.
I went to the range the other day and shot a couple of boxes of DT 9mm +P 147gr through my Sig P239 and HK P2000SK w/o problems.
Not that it means a lot, but I did have a few old Corbon 115gr +P leftovers (probably ~20 yr old) and I fed them to the HK and I had some failures to feed correctly, even though I probably only had ~20rds.
The HK was new, unfired. There is some potential that all the glop they put in there caused problems, but I didn't have problems with any other rounds including the GD 147gr, DT 147gr +P and the Fed Hydroshock 147gr.
Before anyone gives me a hard time, I have a bunch of old Hydrashocks that are about this age and have never had problems feeding or firing in any firearm and I have shot quite a few of them since I had a fair amount.
Also, although non-quantified hearsay, I have heard a number of reports on the Internet of problems with Corbon stuff.
I too, have heard of issues with CorBon (hangs, FTF, bullets not seated), but have always had dependable results. As for the DT, never heard anything negative and use both DT and DPX in all my 9mm's. XD's, PPS, Rami.
However, I am close to supplier for both and I can "proof" in a variety of handgunns much cheaper with the DT than the DPX (or other CorBon's), so what would you bet your life on? Nuf said.
It's possible that the problems (if real) with CorBon have been fixed with the DPX. Admittedly, the stuff I had was pretty old.
.380; 38+p; .357; 9mm; .40----DPX!
I use Double Tap for my carry ammo. I chose the 200 gr in 40S&W. I have order from them about three different times and have been very satisfied. Shipment was prompt and product has been flawless.
It is too expensive for practice ammo, but for actual self defense, I don't worry about a little extra cost. I usually fire a mag full for each of my pistols each time I'm at the range (which for me is about every two months or so.) The ballistics for their ammo is quite superior to most commercial stuff.
There's nothing wrong with Gold Dot and if that's all I had I wouldn't be concerned but... I honestly believe DPX isn't just better, I think it's the best! DPX is in all my CCWs!
ALWAYS carry! - NEVER tell!
"A superior Operator is best defined as someone who uses his superior
judgement to keep himself out of situations that would require a display of his
superior skills."
I carry Speer Gold Dot in my .38spl and .45acp, Corbon DPX in my 9mm. I feel well armed with either of those rounds - and a few others as well: Rem. Golden Sabers, Fed. Hydra-shock, etc.. I haven't tried DT ammo yet but intend to soon, I'm thinking of trying them in 9mm and .380.


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Sayonara !!!
Join Date: Jan 2003
Location: Austin, Texas
Posts: 9,297
Re: Re: My thoughts on "Optimization"
Originally posted by Nv40
exactly.. well said.
I would like that [NVNEWS] post (jimmyjames123) summarry of the current situtation..in the front page of this site ,
it is very important that every gamer outhere knows about those facts
,and let them judge if what Nvidia have done is ok for them or not. because i see frequently post here and there off people that doesnt have a clue of how this "cheat" or "optimization" is any diferent to what ATI and NVIDIA does in games to get best performance wihout the decrease in IQ.
why am I not suprised that you agree with these 'facts'
one point... to contradict a FACT...
the doom3 benchmark scenes were changed by ID... the benchmark itself was not changed... ie the engine and everything else remained the same...
ID's reasons for this were that they felt the scenes nvidia had recorded showed their product in a better light than what was expected... again... ID did not change the BENCHMARK... they changed the scenes used... AFAIK...
here btw is futuremark's response to nvidia's accusations...
I think perhaps both you and jimmy should have a read as to the reasonings given...
note : if it were NOT for 3dmark and tests like it... we would not have an idea of HOW teh gf FX nv30's architecture was organised... we would all still be running round saying its an 8x1 setup... instead of what it really is..
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Apparently if Yorkshire was a Nation on its own, only 9 Nations would have more Gold Medals.
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Chargers' English eager to show he belongs
And English is open to Merriman's tips.
"His past four years in the league, the accomplishments he has made, they speak for themselves," English said. "I want a little bit of that to rub off on me."
But first English has to survive his rookie camp – and that includes carting Phillips' helmet back and forth to the practice field, a timeworn tradition.
"It's just a little thing you have to go through as a rookie," Phillips said. "We don't haze anyone, and we won't make him do anything too crazy, but we'll give him a little bit of hell."
English is fine with that, saying a little helmet duty here and there "comes with the territory." He also is on board being in San Diego, a destination few thought possible considering the players already on its roster.
"I can't say I was surprised, just because I was ready for the unexpected," English said. "That is one thing throughout the process everyone was beating in my head, that you never know what is going to happen. So I was ready for something to come out of left field.
"I landed in a good situation so I am happy and couldn't ask for anything more."
If he does need something answered, he'll just turn to Merriman.
"That is what you are supposed to," Merriman said of sharing his knowledge. "You owe it to the game, period, to do it."


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Emmys 2014: Ryan Murphy encourages all young people to be Larry KramerAdd to Favorites | The 66th Primetime Emmy Awards
In his speech, he thanks the people at HBO, his wonderful cast and "The Hulk and Erin Brokovich" (Mark Ruffalo and Julia Roberts) for getting "this thing alive."
Murphy then goes on to encourage young people to be more like Larry Kramer, the AIDS activist who wrote the autobiographic "Normal Heart" play, and who also joined the cast and producers on stage for the acceptance speech.
"We're going to use the rest of our time to ask young people watching to become Larry Kramers -- to find a cause you believe in, that you will fight for, that you will die for. Go online. Look up amfAR. Look up the Elizabeth Glaser Pediatric AIDS Foundation. This is for all of the hundreds of thousands of artists that have passed from HIV/AIDS since 1981. Your memory and your passion burns on in us and this is for them."
Photo/Video credit: Getty Images


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May 2013
In the wake of the financial crisis and the Madoff fraud, The European Alternative Investment Fund Managers Directive (the "AIFMD") introduces sweeping changes to how alternative investment funds are managed and sold to European investors. Alternative investment fund managers (referenced under the AIFMD as "AIFMs") will be subjected to harmonized rules, regardless of the fund types they manage. The new legislation effectively divides EU investment funds into two categories: UCITS funds and alternative funds. In addition to establishing this simple categorization, the directive also aligns the requirements for managing alternative funds to those for managing UCITS funds. This has significant implications for the alternative investment fund managers, their service providers, the funds themselves and their depositaries.
The AIFM Directive introduces harmonized rules for managers (AIFMs) of alternative investment funds (referred to under the AIFMD as "AIFs") that are sold to EU investors. The Madoff fraud, the Lehman experience (impacting hedge funds) and the political desire to create more transparency around hedge funds and private equity funds were immediate catalysts for this new directive.
The Madoff fraud highlighted varying levels of investor protection across EU member states. The main differences lay in the definition of circumstances in which investors could expect to have their assets restored to them, if they were lost. The directive introduces tough common asset restitution liabilities on EU fund depositaries to address this issue.
The second overarching objective of the directive is to create more transparency. Transparency is a common objective across many recent regulations. Greater transparency is expected to result in more effective supervision, better mitigation of systemic risks, greater accountability and more effective allocation of capital. An example of a transparency measure is the creation of a central public register identifying each AIFM authorised under the directive and a list of the AIFs that those managers manage, or market in the EU.
AIFMD covers all types of alternative investment fund managers, including those who manage hedge funds, private equity funds, real estate funds, commodities and infrastructure funds. The scope is not limited by any regard to investment strategy or legal structure. Large categories of investment funds across Europe, which have traditional rather than alternative investment strategies, also fall within the scope of the directives. These groups of investment funds include, amongst others, German Spezialfonds and closed ended funds, UK Investment Trusts and many funds in The Netherlands.
The extraterritorial scope of the directive becomes apparent in view of the criterion that includes any manager of a fund that is made available for investment to EU investors. This definition includes, for example, both a UK manager who manages a Cayman-domiciled hedge fund and a Japanese manager who manages a Luxembourg-domiciled SIF.
European investment funds are either regulated as UCITS funds, under the UCITS directive, or as AIFs under the AIFMD. Investors hold approximately $6trn of UCITS assets and $2trn of AIF assets. Whilst UCITS funds are authorised for sale to retail investors, AIFs are, in principle, aimed at professional investors. UCITS funds are widely considered to provide a high degree of investor protection. This perception has contributed to the emergence of the UCITS brand and the success of the UCITS vehicle far beyond the EU's borders. Nevertheless, the AIFMD will introduce investor protection standards for AIFs that are higher than those currently in effect for UCITS vehicles. This will create an unintended anomaly, where professional investors buying into AIFs are better protected than those investing into UCITS vehicles. UCITS V will correct this anomaly and introduce equivalent depositary requirements for AIFs and UCITS vehicles.
Level 1 of the directive was published in July 2011. This level of the legislation must be transposed into EU member states' legislations by 22 July 2013. Germany, Luxembourg and The Netherlands have been the first to publish draft local laws. The approach has been slightly different in each country. In Germany, for example, the legislator has largely rewritten the law into the new KAG-B. Luxembourg, in contrast, has taken the "loi chapeau" approach and implemented an umbrella form of legislation to apply over and above current relevant fund laws. The UK financial regulator may rewrite large parts of the COLL into a new FUNDS handbook. Overall we might see a gradual and often delayed adoption by member states, analogous to the UCITS IV adoption pattern.
The more detailed AIFMD legislation, Level 2, clarifies particular aspects of the Level 1 directive. Level 2 takes the form of a regulation and is directly applicable at a national level. EU regulations eliminate national divergence in their application and are therefore a strong tool for harmonization across member states.
Considering the effort required by all value chain participants to become compliant, the time between the prospective issuance of Level 2 regulations and AIFMD coming into effect is very short. Although managers have 12 months from 22 July 2013 to apply for an authorization as an AIFM, the industry as a whole has to be careful not to push out the compliance efforts until the end of the period as this could create bottlenecks.
In addition to defining its own scope, the AIFMD explains the authorization process the manager has to go through, the conditions under which it must operate as well as its reporting requirements.
AIFMD impact all actors in the fund value chain, whether supervisory authority, investor, manager, depositary or service provider. However, the directive is primarily aimed at describing the manager's duties and obligations and does this taking into account to the context in which the manager operates.
All parties in the value chain have their particular role:
All parties in the fund value chain will have to explore new operating models and determine which ones will achieve the highest level of investor protection whilst containing the impact on investment returns as costs to serve go up.
Alternative Investment Fund Manager coming within scope of the directive1 face a long list of organizational and transparency requirements that they must fulfill. These include valuation requirements, transparency reporting requirements risk and compliance requirements.
The manager must think strategically about how these requirements can be met. The considerations range from organizational design to delegation arrangements and data architectures.
The organizational design is critical to avoid conflicts of interest and is essential to meet the requirement for functionally and hierarchically independent risk management and valuation functions. Delegation can play an important role in achieving these objectives.
Also very significant are the transparency reporting obligations to investors and supervisory authorities. The EU Commission's impact assessment acknowledges that managers will incur additional costs when complying. The administration service provider can help support the manager's compliance as it is already a main repository of fund data. The transparency reporting is split into three major categories: annual reporting, investor reporting and regulatory reporting.
Drawing the required information together from multiple sources and repurposing it for reporting and management purposes is a significant task. A thorough consideration of the overall data architecture and the delegation arrangements may lower the risk and cost of the envisaged solution. Together, the alternative investment fund manager and its service provider can devise effective strategies for compliance.
One of the key outcomes of the AIFMD should be a standardization of depositary duties and liabilities across the EU. This should offer investors greater choice of funds as they know they will enjoy a common standard of oversight, safe-keeping and liabilities regardless of the domicile of the fund. The depositary must, in order to fulfill its duties and responsibilities under AIFMD, fundamentally revise its oversight processes and the infrastructure it uses to support that process. Many alternative investment funds have to date not required a depositary and for the managers of these funds the interaction with the depositary is new.
The depositary duties and responsibilities include:
These duties add up to a significant programme of work that the depositary must undertake for each fund it oversees. Every area of responsibility has its own set of implications. For example, the EU Commission foresees that the depositary becomes a central hub where all information related to the AIF's cash flows is centralized, recorded and reconciled. This may imply that the depositary must record cash transactions in a position keeping system. Apart from the considerable operational effort and technology infrastructure required to fulfill this requirement, the cash monitoring requirement also puts additional focus on the depositary contract as the AIFM and all third party entities must send all cash account information to the depositary, without undue delay.
Groups with depositary entities in multiple EU jurisdictions are well placed and have an opportunity to harmonize and build on their current capabilities to service funds under AIFMD. An exhaustive analysis should be undertaken to compare every function currently performed in each jurisdiction, including the tools supporting the function, the associated volumes and the complexity. This as-is analysis can serve as a baseline for the gap analysis against the AIFMD technical standards. The gap analysis would show what tools and controls need to be developed to ensure compliance. As AIMD has largely harmonized the depositary requirements across jurisdictions, the group depositary can equally harmonize its processes and reduce procedures across the jurisdictions in which it is active. This should lead to more efficiency and somewhat the overall increase to the cost of providing depositary services.
The safe-keeping of assets held in custody is associated with a special risk for the depositary — the restitution liability. The depositary must return an asset, or its equivalent value, to the fund, if the asset is lost. The scope of the definition of assets that can be held in custody has therefore become a key aspect of the AIFMD implementation debate. The implication for the depositary is that it must further mitigate the risk of an eventual loss. This might be partially achieved by tightening the contractual terms with sub-custodians and the on-going due diligence programmes undertaken over them as well as the markets in which they operate. However, the additional costs of these initiatives have diminishing returns. It is practically only fraud and error, coupled with insolvency at the level of the sub- custodian that might lead to a loss of assets. The depositary must insure itself against these losses by increasing the capital it holds against such a loss event. The cost of this capital is a real cost of investor protection and the depositary will expect to recoup that cost to protect its margin.
It is currently common for prime brokers to hold hedge fund's assets in their own global custody network. Under AIFMD, the AIF has to appoint a depositary that holds all the fund's assets. This means that a continuation of pre-AIFMD models can only be continued if the requirements of delegation of safe-keeping by the depositary to a third party are met.
There are several hurdles to overcome before such a delegation could take place. The prime broker must demonstrate that it has functionally and hierarchically separated the performance of its safe-keeping functions from its tasks as a prime broker. And, the prime broker's potential conflicts of interest must be properly identified, managed, monitored and disclosed to the investors of the AIF. However, the depositary will be reluctant to appoint a prime broker as sub-custodian as the assets for which the depositary is liable for restitution would sit outside its own network and immediate control.
In all cases, the AIF or AIFM must inform the depositary of the contracts it has entered into with prime brokers. The fund manager must also inform the depositary about the due diligence performed in the selection and appointment of prime brokers. The prime brokers will, in turn, be required to make detailed information available to the depositary about its business with the fund.
The relationship between the AIF and the prime broker must also be disclosed to investors. Apart from the identity of the prime broker, investors must also receive a description of the business arrangements between the AIF and the prime broker, as well as any conflicts of interests that may arise in relation to those arrangements, and how the conflicts are mitigated. Investors must also be made aware of any provisions in the contract between the depositary and the prime broker which makes a transfer or reuse of AIF assets possible.
Collateral also plays a key role in the relationship between the hedge fund, the prime broker and the depositary. AIFMD stipulates that the depositary remains liable for restitution of in-custody assets, regardless of whether the assets a subject to repo, securities lending or collateral arrangements. The definition is that the asset remains with the depositary, unless the title to the asset has been transferred. Different models might emerge to accommodate collateral arrangements in the most efficient manner.
1 To operate in the EU, all AIFM with assets under management ("AUM") exceeding €100 million (or €500 million for closed ended unleveraged funds) must obtain initial authorization from their member state regulators by providing information on themselves and their AIFs. AIFMs whose AUM do not reach these thresholds may opt in to the full regime.
BNY Mellon is the corporate brand of The Bank of New York Mellon Corporation and may also be used as a generic term to reference the corporation as a whole or its various subsidiaries. Products and services may be provided under various brand names. Products and services may be provided by various subsidiaries, affiliates, joint ventures and in some instances by third party providers of The Bank of New York Mellon Corporation where authorized and regulated as required within each jurisdiction, and may include The Bank of New York Mellon, One Wall Street, New York, New York 10286, a banking corporation organized and existing pursuant to the laws of the State of New York and operating in England through its branch at One Canada Square, London E14 5AL, England. Registered in England and Wales with FC005522 and BR000818 and authorized and regulated in the UK by the Financial Services Authority. Not all products and services are offered at all locations.
This material contained in this brochure is for general information and reference purposes only. It is not intended to provide legal, tax, accounting or other professional advice or investment advice on any matter, and is not to be used as such. BNY Mellon recommends that professional consultation should be obtained before using any investment service. This [brochure], and the statements contained herein, are not an offer or solicitation to buy or sell any products (including financial products) or services mentioned. This material is not intended for distribution to, or use by, any person or entity in any jurisdiction or country in which such distribution or use would be contrary to local law or regulation. Similarly, this material may not be distributed or used for the purpose of offers or solicitations in any jurisdiction or in any circumstances in which such offers or solicitations are unlawful or not authorized, or where there would be, by virtue of such distribution, new or additional registration requirements. Persons into whose possession this [brochure] comes are required to inform themselves about and to observe any restrictions that apply to the distribution of this document in their jurisdiction.


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February 5th, 2011by rusty
Does anyone have any thoughts on suicide by drinking anti-freeze?
Does anyone have any thoughts on suicide by drinking anti-freeze?
4 years ago • General
Feb 05, 2011 @ 14:59:10
Don't do it! They don't put the chemical that was really lethal in it anymore all your gonna get is pain!
Feb 05, 2011 @ 15:36:28
what i know(from many documentary i have seen) is that if you overdose it you WILL die within a few hours but its gonna be painful because you will suffocate.
Feb 05, 2011 @ 15:59:11
I just want to find a way to die at home in bed.
Feb 05, 2011 @ 16:06:15
Don't try antifreeze I really think it's a bad idea and seriously painful bit like drinking bleach. How old and where you from rusty?
Feb 05, 2011 @ 16:08:20
37. Virginia.
Feb 05, 2011 @ 16:12:37
How about Ambien? is it possible to OD and pass away on that?
Feb 05, 2011 @ 16:17:36
Google antifreeze and take the wiki link. Ethylene glycol poisoning. Take your chances with helium or hanging if you really want out.
Feb 05, 2011 @ 16:18:55
Why do you want to die rusty?
Feb 05, 2011 @ 16:23:33
My life is hell and I'm out of options. I cant find work, I'm ill, I'm out of money, I lost the love of my life, all my friends have abandoned me, I'm 100 grand in debt and will be homeles in a few days. I've been struggling with these problems for years, as wel as mental illness. I always keep fighting and trying, but I'm done finally. I want peace. I don't want to be around to hurt people anymore. I want an end to my pain, that I know will only get worse in time.
I know a lovely place to jump a few hours away with a 600 foot drop. But I'd rather do it at home, and leave my body in one piece for my family.
Feb 05, 2011 @ 16:26:07
Its not a thing I can talked out of now. I'm going to die and soon. It's just a matter of how. I want i to be a sure death, no fuck ups. I want it to be as painless as possible, or a least quick. And if I can leave my body intact all the better.
But if I don't find an at home option soon, I will jump off that bridge or hang myself from another, probably with even of a drop to decapitate myself so I can't be rescued.
Feb 05, 2011 @ 16:27:23
I have an ambien prescription I have yet to fill. What would I need to do to ensure ambien kills me? Would I have to take something else in conjunction with it?
Feb 05, 2011 @ 16:32:55
I'm sorry man. I know what it feels like having your back against the wall. I share a lot of the same problems.. except I've never found the love of my life.
Does your family know how you feel? How are they gonna handle finding your body? I'd rather not let them find me if possible.
Feb 05, 2011 @ 16:37:08
I don't know about ambien.. I've heard too many horror stories about people ODing on pills and waking up in the hospital worse off than before.
I think I'm leaning towards hanging myself.. I just learned how to tie a slip knot.
Feb 05, 2011 @ 16:45:43
Rusty, I'd really like to try to help and tell you you shouldn't do it but I'm in the same place you are so I'd feel like a hippocrite telling you that. Any depressed person knows that at somepoint it all gets to much and you will make an attempt. If I think back in the past I've always been trying to find the solution or the thing that will change the depression. It has never even been close to coming. I hope you find peace rusty!
dylan and pretty boy
Feb 05, 2011 @ 19:11:30
Ambien is not a good idea Rusty. It would just leave you with more problems than you have now. I feel much like you, I'm in Maryland, a bit older than you. I also feel like I'm out of options and have been considering methods.
Feb 05, 2011 @ 19:44:04
Thanks. I think I'm just going to drive out to the bridge tomorrow. I'm ready. I'd go tonight but there's probably snow up there. Better to wait for daylight.
Sep 20, 2012 @ 12:11:08
rusty, are you still there ?
Sep 23, 2012 @ 19:01:40
Rusty … U still there? I'm where u are……as a side note….mineral spirits is not much help.drank 6oz and got bad diarrhea. And mineral spirits is a solvent…so therefore my asshole really feels like it got ripped a new one.Then tried 4 oz of antifreeze…really bile stuff. Kept it down though. So we will see…..
Sep 23, 2012 @ 19:19:22
idk about antifreeze, Its the exact opposite of what id do. To die i am looking for a natural means, whether by drowning or natural poison. i bet u have some of these plants in your backyard
Black Swan
Sep 23, 2012 @ 19:32:41
Rusty the only painless non gruesome death out the is the helium or nitrogen hood or barbiturates. The rest of the pills including Amibien, won't ever kill you no matter the amount you take.
I share similar circumstances and I am also your age. I wish I had the courage to jump of a bridge cause that's the only viable option for me.
I wish you peace when you leave if you go ahead with it. Just please think beautiful thoughts as you exit this world, as some say you will carry your last state of consciousness onto the "next realm", if there is such a thing. Just in case it doesn't hurt to do this.
Sep 25, 2012 @ 17:34:45
Well….it's a new day. At 2pm i was finally able to ingest 8oz of antifreeze from store up the road. It took the help of eating a hot dog to get past the Bitrex. I am reasonably intoxicated and proud to be able to keep the bitter/sweet potion of death in my system.
May or may not comment any more after this. Wish me luck!!!!!
Oct 01, 2014 @ 14:01:18
I hope you're ok
Apr 28, 2013 @ 05:43:34
Hi. I know a lot of you are in pain and thinking about killing yourselves because you feel like you are out of options.
Please wait. There's always another option. Move to Thailand and teach English. Go volunteer with people who are mentally or physically disadvantaged.
If you are thinking about offing yourself because of finances, declare bankruptcy or even walk away. It's not worth killing yourself over. My Plan B is to just charge up one last ticket and move to some country that it's cheap to live and teach English by telling people that we use and immersion technique and we only speak English in this class. That will make up for
If you're in pain because of love- I know, it sucks. But you'll probably feel less strongly in five years. Maybe rescuing a dog from the pound will help a little bit.
If you have medical problems and are broke there has to be a state that offers better services. West Hollywood, CA has a lot of services and help for certain conditions. The City of Hope hospital supposedly doesn't turn away anyone because of finances. If you are about to be homeless, take the last little bit of money and get on a bus to a city with good services for homeless people. Things will get better.
There's always another option. I understand that the pain you feel is overwhelming and that it gives tunnel vision and blocks you from seeing other options but really try to picture under what conditions you can ditch whatever environment you are in and start over.
Call a suicide hotline when you have urges and plan for change. I used to work in the dept in the hospital where people woke up after failed suicide attempts and I can tell you that whatever was wrong before didn't get better with three broken limbs, burnt stomach and/or brain damage. Flip the dice in a different way. See if you can get out of your own head by going elsewhere and helping someone who maybe has fewer limbs than you or a hurt animal or something. Change your environment dramatically. Go see a psychiatrist and see if it's something chemical that can be changed.
I've had bad depression before- I know how dark it can be. Do anything other than what the depression is telling you to. Things will get better. Just keep changing things up until things get better. Helping others will be an important key but maybe pick something that is different from the problems you are having. I volunteered building wheelchairs for kids without limbs overseas who have no access to wheelchairs and their parents have to take them to the bathroom even if they are 15 or 17. That wheelchair gives the person instant freedom and some possibility of privacy. And building it gives me a little time to focus on something other than my problems. (I do it through Wheels For Humanity and LAWorks.com
Things will get better. Change things until they do. Good luck!
Apr 28, 2013 @ 06:28:54
P.S. That should say St. Jude's Children's Hospital (for cancer) not City of Hope but there have to be other hospitals that don't turn anyone away because of finances and if you search you can find hospitalize that specialize in different conditions.
David Burns wrote a really good book called Feeling Good: the New Mood Therapy which talks about how depression, PTSD, and/or pain can cause thoughts to be distorted which then distorts feelings and makes you feel like the hopelessness will never end. Sometimes changing your environment can help, other times you might need a therapist and/or psychiatrist to help you change your distorted thinking patterns and/or check on the chemical balance of your brain.
Get help. Most cities have free/low cost clinics or sliding scales for therapies. Check with the local gay and lesbian center even if your heterosexual, they can either provide services or point you in the right direction.
There's something called 5150 where you can call and be hospitalized for up to 72 hours if you ever feel like you might hurt yourself or others. They will probably basically sedate you and point you to free / cheap help. There are even programs to get meds. The two friends I had who were 5150'd by relatives said that it helped a lot. One got to stay at a county-run facility for two weeks until she was feeling stabilized and under the care of a psychiatrist.
Not all psychiatrists are good (most are ignorant power-trippers) so find someone who has good references and/or reviews and clicks well with you. Ask a friend to help you. You can find a nonprofit who can help you, or maybe a social worker or case manager, or maybe you can even go to an AA meeting and get a sponsor to help you even if you don't have alcohol issues. Please find help. You can do it. Things will get better.