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Teen parents fighting over whether their shaken baby daughter should be removed from life support have taken their case to Ohio's courts and exposed a potential loophole in state law.
Six-month-old Jada Ruiz has been on life support at Akron's Children Hospital since early March when police officers, responding to a 911 call, found the baby unresponsive and not breathing in the arms of her 17-year-old father John Jones.
Doctors diagnosed Jada with broken bones, detached retinas and brain damage consistent with shaken baby syndrome, child services authorities said. The doctors said the little girl has little hope for life beyond the tubes and machines currently sustaining her, according to lawyers for both parents.
Police records confirm the severity of Jada's injuries, noting "her recovery is unlikely." Her twin, Jasmine, also was found with severe, but non-life threatening injuries.
Jada's mother, 18-year-old Deja Ruiz, wants her daughter removed from life support. But Jones, who was charged with assault and child endagerment in the case and who could face murder charges if Jada dies, quickly filed court papers to keep his daughter on life support.
The case is now in Summit County Probate Court where it has morphed into a series of complicated legal battles over who has the right to make such a decision, which court has jurisdiction over the case and who should have custody over Jada and the couple's other two children, Jada's twin sister and a 2-year-old boy.
Ruiz, who has not been charged in Jada's assault, spends most of her days at the hospital with her daughter. She is also working toward regaining custody of her other two children, who were removed by authorities after Jones' 911 call.
"She's having a hard time dealing with it," Ruiz's attorney Mary Ellen Leslie said, adding that Ruiz believes Jada "is already in the hands of God."
"She doesn't want to see that baby laying in bed, day after day after day," Leslie said.
Jones, who was enrolled in public school and is now being held in a juvenile detention center, is angry, depressed and frustrated, his lawyer Pam Hawkins said. Jones denies he caused the twins' injuries, but Hawkins declined to offer another explanation of the girls' injuries.
According to the police report, Jones was at Ruiz's home while she was at school. He told police, according to the report, that he found Jada limp and unresponsive when he went to change her diaper. He also told police that the girls were born four months premature and have a history of respiratory problems.
Akron Police Lt. Rick Edwards said the department is still investigating the abuse of the children.
Some have questioned Jones' motive questions for keeping his daughter alive.
"I would question his suitability as a parent to make a decision based up on the charges," Leslie said.
Hawkins said the possibility of murder charges did not play a role in Jones decision. She said the teen is planning to file paperwork soon to challenge Ruiz for custody.
"He made this decision before he was ever arrested," she said. "He has wanted her to get all the treatment she can to have the best chance for recovery."
But even Hawkins admitted she has been told that Jada's condition is "grave."
A spokeswoman for Akron's Children Hospital said it could not comment on Jada's condition or injuries, citing confidentiality laws.


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Humor - Page 21
Man Rides a Pig to Work for Most Unique Commute Ever
President Obama Stops By 'Between Two Ferns' With Zack Galifianakis [VIDEO]
'SNL' Brings in Liam Neeson to Solve the Crisis in the Ukraine
The world is a little more terrifying than usual these days. With Russian forces occupying Ukraine's Crimean peninsula, the internet has already started throwing around references to World War III. Thankfully, 'SNL' is here to take something that has us terrified and make us laugh instead. The show's solution? Bring in Liam Neeson.

subset: commoncrawl


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IceRays' misery in Wichita Falls continues with OT loss
Wildcats goalie Leon continues to stymie CC
WICHITA FALLS - Matt Leon and the Wichita Falls Wildcats continue to flummox the IceRays.
Wichita Falls rallied from a third-period deficit to defeat Corpus Christi 2-1 in overtime on Saturday night at Kay Yeager Coliseum.
The IceRays (18-17-3, 39 points) did pick up a point for the overtime loss, putting them six points ahead of Odessa for the final playoff spot in the North American Hockey League's South Division after the Jackalopes' victory at New Mexico.
Saturday was the IceRays' final regular-season visit to Wichita Falls this season, and they're likely not eager to return after going 1-4-1 there, including five consecutive losses. The Wildcats (14-23-3, 31) have won six of the eight meetings against the IceRays this season.
Once again, the IceRays couldn't find a way to beat Leon, who made 31 saves to improve to 6-0 against Corpus Christi, with just seven goals allowed in those six starts. Conversely, Leon is 4-8-1 against everyone else.
"We've got to find a way to solve Leon," IceRays coach Justin Quenneville said. "There are no excuses. As a coach, I can't ask for more opportunities offensively, but we've just got to find a way to put pucks in nets.Leon has been playing great hockey for them against us. He steps up. At the end of the day, we control our fate. I feel like if we control our opportunities and we have a lot against them, then why aren't we scoring?
"I need leaders on the ice, and if we can crack a few behind (Leon), we give ourselves our chance. Defensively, we do a (good) job and (goalie Anthony Stolarz) gives us a chance to win every night."
The game ended after the only shot of overtime. Wildcats defenseman Tucker Poolman carried the puck up left wing and his backhand shot from the bottom of the left circle made its way through Stolarz's pads at the 2:39 mark of the extra session.
The IceRays held a 1-0 lead and were on the power play early in the third period before giving up a short-handed equalizer, with Chris Pontello finishing on a two-on-one rush.
Pontello took Tanner Fahlstedt's pass in the slot and Stolarz got a piece of the shot, but not enough to prevent the goal at 5:08.
The game had been goalless until past its midway point, when the IceRays broke through while on a power play.
From the center of the blue line, Beau Walker hammered a slap shot past Leon at 10:41 of the second.
Corpus Christi 0 1 0 0 — 1
Wichita Falls 0 0 1 1 — 2
First Period— None. Penalties— Pochiro, WF (hooking), 9:29; Holstrom, CC (tripping), 15:06; Soloviev, WF (interference), 19:23.
Second Period— 1, CC, Walker 8 (Jarosz, Maxwell), 10:41 (pp). Penalties— Walker, CC (roughing), 1: 29; Purmal, WF (roughing), 1:28; Purmal, WF (holding), 8:59; D'Arrisso, CC (holding), 11:52; Hruska, CC (roughing), 13:05; Pagonis, WF (roughing), 13:05; Dery, CC, major (fighting), 15:00; Pochiro, WF, minor-major (roughing, fighting), 15:00.
Third Period— 2, WF, Pontello 10 (Fahlstedt, Purmal), 5:08 (sh). Penalties— Szopinski, WF (checking from behind), 3:28; Fetzer, CC (holding), 10:36; Lutsch, CC (hooking), 18:32; Parker, WF (slashing), 18:59.
Overtime— 3, WF, Poolman 5 (Purmal, Fahlstedt), 2:39. Penalties— None.
Shots on goal— Corpus Christi 12-13-7-0—32; Wichita Falls 9-9-12-1—31. Goalies— Corpus Christi, Stolarz 15-11-2 (31 shots-29 saves); Wichita Falls, Leon 10-8-1 (32-31). Power-play opportunities— Corpus Christi 1 of 6; Wichita Falls 1 of 4. Referee— Matthew Wyld. Linesmen— Rick Lembo, Brian Earnest. A— 2,677. T— 2:26.
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"Is 8 Mile still relevant 10 years later?" she (who shall remain nameless) asked. All of the eyes in the tiny room darted over with the look of a simultaneous yet friendly "Duh!" It was seemingly an obvious answer to a very valid question on the heels of the flick's 10 year anniversary.
About a month ago I sat in front of a mounted flatscreen watching 8 Mile for probably the 107th time. Exaggeration, yes, but it sure felt like it. It debuted my freshman year in college to a crop of eager hip-hop fans and devout Eminem followers. But the film meant the most to the natives of Motor City. The Motown era had been long gone. Detroit hadn't been the heart of exceptionally great musical talent in years. That was until Eminem. Then 8 Mile.
Not only is 8 Mile still relevant it's a cultural marker of a specific time in hip-hop. By no means was it the first fictional movie based on an aspiring rapper, but it set the standard for any movies of the same ilk that followed. The storyline was believable. It felt authentic. You were invested in the friendship of B-Rabbit (Eminem), Sol George (Omar Benson Miller), Future (Mekhi Phifer) and Cheddar Bob (Evan Jones); and chose sides in their rivalry with Papa Doc (Anthony Mackie) and Wink (Eugene Byrd) the rest of the Free World. And you gave a side-eye to Alex (Britney Murphy) for her groupie-esque actions. The casting could not have meshed better.
To mark its importance in film and hip-hop, VIBE magazine's October/November issue put Eminem on the cover. The cover story wasn't the standard feature on Em alone. Instead the cast reunited for an interview filled with never heard before tidbits about the movie's making. Not just any film's anniversary makes it on to one of the most respected hip-hop magazine's cover.
As I sat on the floor watching 8 Mile last month I didn't think about what it meant 10 years later, or how my countless friends from Detroit–if you know anyone from Detroit you know they love their city unconditionally–felt seeing only a glimpse of their hometown portrayed through the lens of hip-hop. I actually didn't think much of anything. I was too busy immersed in the film, reciting lines, as if it was the first time way back during freshman year. What that means as it relates to its significance today, 10 years later–I'm not sure. It has to mean something, though.
[Photo: Universal Studios]


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Ohio Northern University News
Lovett Distinguished Lecture Series focuses on 'Evolution of a Family Business'
Ohio Northern University's James F. Dicke College of Business Administration will present "Evolution of a Family Business," a lecture by Robert Gronlund, as part of the Carroll V. Lovett Distinguished Lecture Series in the Dicke Forum on Thursday, Oct. 16, at 7 p.m.Gronlund, chairman and chief... more
Ohio Northern University Symphony Orchestra opens season with performance of 'Nature'
Ohio Northern University's Freed Center for the Performing Arts presents the Ohio Northern University Symphony Orchestra with a performance of "Nature" on Saturday, Oct. 18, at 7:30 p.m. Works include "Die Moldau" by Bedřich Smetana, "Rusty Air in Carolina" for orchestra and electronica by living... more
Ohio Northern University's Mu Delta chapter of Beta Alpha Psi begins recruiting season
The Ohio Northern University Mu Delta chapter of Beta Alpha Psi kicked off recruiting season with the second annual "Meet the Firms Night" on Sept. 4 in the ONU McIntosh Ballroom.More than 50 students attended the event, including undergraduate accounting majors and concentrations as well as Master... more
Ohio Northern University presents screening of 'Blueberry Soup'
Ohio Northern University's Center for Democratic Governance and Rule of Law will present a screening of "Blueberry Soup" and hold a panel discussion on the documentary with filmmaker Ellen Jarrett in the Dicke Forum on Tuesday,Oct. 7, at 7 p.m. The event is free and open to the public."Blueberry... more
Ohio Northern University named a 2014-15 Military Friendly School
Ohio Northern University has been named a 2014-15 Military Friendly School by Victory Media. This distinction recognizes Ohio Northern for ranking in the top 15 percent among all universities and trades schools nationwide in welcoming military and veteran students.Schools and universities on the... more
Ohio Northern University presents a celebration of choral music
The Ohio Northern University Department of Music presents a celebration of choral music as part of the ONU Homecoming festivities in the Snyder Recital Hall in the Presser Building on Friday, Oct. 3, at 8 p.m. The event is free and open to the public.The evening's program will begin with the ONU... more
Ohio Northern University's Homecoming is 'A Celebration of ONU Stars'
Ohio Northern University will celebrate Homecoming 2014 from Oct. 3-5. All alumni, friends, family, faculty, staff and students are welcome to attend. Homecoming, "A Celebration of ONU Stars", will kick off on Friday, Oct. 3, with registration at 2 p.m. At 6:30 p.m., former athletes will be honored... more
Ohio Northern University to present 'Dancing with the Ada Stars' as part of Homecoming festivities
The Ohio Northern University Freed Center for the Performing Arts presents "Dancing with the Ada Stars" on Saturday, Oct. 4, at 8:30 p.m. for the 2014 Homecoming performance. Patterned after the highly popular ABC show "Dancing With the Stars," local celebrities will compete for the prestigious... more
Ohio Northern University to present forum on 'Crisis: Freshwater in Northwest Ohio'
Ohio Northern University's Phi Beta Delta honor society for international scholars and the ONU chapter of Gamma Theta Upsilon, an international honor society in geography, presents "Crisis: Freshwater in Northwest Ohio" in the Dicke Forum on Wednesday, Oct. 8, at 7 p.m. The event is free and open... more
Ohio Northern University's Keiser Distinguished Lectureship in Life Sciences to discuss 'Wilderness, Wildness and Biodiversity'
Ohio Northern University will host a lecture by Reed Noss, the provost's distinguished research professor at the University of Central Florida, in the Freed Center for the Performing Arts on Tuesday, Oct. 7, at 7:30 p.m. This lecture is free and open to the public.Noss' presentation, titled "... more
Ohio Northern University presents faculty recital, special guest featuring chamber music
The Ohio Northern University Department of Music presents an evening of chamber music in the Snyder Recital Hall in the Presser Building on Monday, Sept. 29, at 8 p.m. The event is free and open to the public.The program will feature Paul Moravec's Pulitzer Prize-winning Tempest Fantasy for... more
Ohio Northern University to induct six into ONU Athletic Hall of Fame
Six members of the Ohio Northern University athletic family will be inducted into the University's Athletic Hall of Fame on Friday, Oct. 3, as part of ONU's Homecoming weekend.They will be inducted that Friday during a banquet in Ohio Northern's McIntosh Center at 6:30 p.m. and introduced Saturday... more
Ohio Northern University to observe Constitution Day with presentation on 'Making Constitutional Law Today'
Ohio Northern University will observe Constitution Day with a presentation from prominent labor and employment attorney Gary Lofland in the Pettit College of Law's Celebrezze Moot Court Room on Thursday, Sept.25, at noon. The event is free and open to the public.In his presentation, "Making... more
Ohio Northern University presents 'The Importance of Being Earnest'
Ohio Northern University's Freed Center for the Performing Arts will present "The Importance of Being Earnest" from Sept. 25-27 at 7:30 p.m. There also will be two matinee performances on Sept. 27 and 28 at 2 p.m.Oscar Wilde's masterpiece "The Importance of Being Earnest" focuses on two bachelor... more
Ohio Northern University teams up with PepsiCo to increase recycling efforts on campus
Ohio Northern University has announced that it will advance its recycling efforts by teaming up withPepsiCo Recycling to bring a PepsiCo Dream Machine kiosk and added recycling incentives to campus.The PepsiCo Dream Machine kiosk introduces a rewarding program that provides students with an easy... more
Ohio Northern University to introduce 'Brother 2 Brother' initiative
Ohio Northern University will introduce the "Brother 2 Brother" initiative to the campus with a kickoff event in the Dicke Forum on Wednesday, Sept. 17, at 10 a.m.Part of the national Student African American Brotherhood (SAAB) program, the Ohio Northern University's Brother 2 Brother initiative... more
Ohio Northern University ranked No. 2 by U.S. News & World Report
Ohio Northern University has been ranked No. 2 among Midwest regional colleges in "Best Colleges 2015," which is published annually by U.S. News & World Report.Ohio Northern has appeared in the top 10 of the publication's Regional College Midwest Rankings for the past 23 years and in the top... more
Ohio Northern University's College of Engineering ranked in the top 50 by U.S. News & World Report
Ohio Northern University's T.J. Smull College of Engineering has been recognized as one of the nation's top 50 undergraduate engineering programs in "Best Colleges 2015," published by U.S. News & World Report.The college ranks 41st among engineering schools whose highest degree is a bachelor's... more
Ohio Northern University to dedicate Kerscher Stadium
Ohio Northern University will dedicate its newly renovated track and field and soccer complex as "Kerscher Stadium" prior to the ONU men's soccer game against Case Western University on Saturday, Sept. 20, at approximately 6:45 p.m.The stadium is named in honor of Dr. Robert Kerscher and his wife,... more
Ohio Northern University student receives UPS Scholarship
Ohio Northern University student Shalom C. Arellano, a senior exercise physiology majorfrom Garfield Heights, Ohio, has been selected to receive a UPS Scholarship provided through Foundation for Independent Higher Education (FIHE).FIHE is a statewide association for private colleges and... more


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No assists from Sottie Pippen
from Meek Mill – The End (Outro) Lyrics on Genius
Meek needs no help like Michael Jordan did. He doesn't need the assistance from Scottie Pippen or any major labels. Meek can get 6 rings/grammys on his own, through his skill and passion for hip hop.
To help improve the quality of the lyrics, visit Meek Mill – The End (Outro) Lyrics and leave a suggestion at the bottom of the page


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After Mary walks off the set and the lights dim, the cast returns for a curtain call.
No big surprise In 2nd, Mr. Moralize But who should take a curtain call?
My father did not want the audience leaving with such a sad feeling so he orchestrated a curtain call of gradual, joyful clapping.


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This was an enjoyable hotel. Clean and comfortable. Nice staff & a good location to both Amish...
See full review
This was an enjoyable hotel. Clean and comfortable. Nice staff & a good location to both Amish...
I love this hotel, love the interior of the hotel lobby, nice ambiance, neat and clean fresh smell....
See full review
I love this hotel, love the interior of the hotel lobby, nice ambiance, neat and clean fresh smell....
Customers who viewed Holiday Inn Express & Suites YORK NE - MARKET STREET also booked these hotels.
Rates quoted in currencies other than the hotel's base currency are subject to the rate of the international exchange. Rate may change throughout stay. Rate may reflect average nightly rate. Extra charges may apply. Incidental charges, such as room service, are not included in the rate.
The amenities and/or facilities may not be located at the hotel, but within a reasonable distance, and additional charges may apply for use. All information has been provided by this hotel and not by Orbitz
Overall score
would recommend to a friend.
Reviewer score
Would recommend
little girls birthday weekend
I booked a room for my 10 year Old and her friends to celebrate her 10th birthday. The room was more than big enough for 5 little girls and my self. there was 2 queen size beds and a sofa bed the room also had a microwave and refrigerator. The
bathroom and room were clean and had lots of room for board games, nail painting and bracelet making. The hotel had a nice indoor pool and hot tub that the girls enjoyed open from 8am to 10pm however there is no life guard . They also loved the hot free breakfast which included Pancakes, french toast, eggs, bacon, sausage, bagels, fruit, yogurt and so much more which was a selling point for me because it is a money saver. The hotel is also located next to a nice pizza shop that we walked over too and really enjoyed. There is also a Gas station and store with walking distance for snacks or you can buy some snacks from the lobby. Overall this hotel was great for a girls weekend and the staff was very nice and didn't mind the number of little girls running around.
Great family trip
The hotel was new and the rooms were very clean. My family had a great time there.
Very comfortable stay
This was an enjoyable hotel. Clean and comfortable. Nice staff & a good location to both Amish Country and Lititz.
Exactly What you Expect from a Holiday Inn Express
Great value, clean room, nicely appointed and decorated. Affordable. Did not spend much time at the hotel, just used a place to sleep and shower. We were only there for a night visiting Lancaster. York is about 20 miles away, took us about 25
minutes to get to downtown Lancaster. Staff was very friendly (except for the cleaning lady, she kept knocking on our door before check out time, a little big annoying but really no big deal). Breakfast was what you'd expect, nothing fancy but it's nice to have the option. Free Wi-Fi, Free parking. Didn't check out the gym or pool. I'd recommend to anyone who wanted a safe bet.
great stay, highly reco!
We were in York visiting family and just needed a clean and quiet place in the area to stay for one night. Spending hundreds of dollars for such a thing (in middle of nowhere PA) sounded ridiculous so when I stumbled upon this place I was happy. I
was even happier when we checked in because it's brand new, conveniently located and up on a very quiet, sunny hill. For our purposes it was outstanding. Friendly staff, clean, quiet and NEW! For the money you're not going to find anything that tops this. Oh - we left early Sunday morning but there were A LOT of people downstairs for breakfast and they were all smiles so I can only imagine that's a plus too (but can't personally reco myself).
Qulaity and Pristine Look on a Budget!
Booked my work team and myself here for our stay for the week while onsite in Lancaster, PA. The rooms were some of the best looking and clean rooms I've seen at a hotel in ages. The hotel staff was very friendly and accomodating to any needs and
questions you had. The staff was greeting and welcoming even first thing in the morning at breakfast. Beds were very comfortable and room was spacious for late-night work and personal relaxion. Very well recommended.
Family bonding
I love this hotel, love the interior of the hotel lobby, nice ambiance, neat and clean fresh smell. We had a nice- okay free breakfast. We had the king suite room, it was spacious, clean and the only complain I have was the room a little bit dark
maybe because of the room color but other than that it's nice.
Holiday Inn Express York
Bathroom was a little ify, but overall very nice and comfortable.
2 night stay
Good Stay...Clean...Staff was attentive...stay exceeded my expectations...would stay here again...
Short drive to multiple dining establishments
Awesome family getaway
Clean, newly renovated, friendly staff and convenient location to local attractions.
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|208 posts found
[Column] Guild Wars 2: 'LOL'
News & Features Discussion « General Discussion
Goyya love listening to the 2 Charr who are operating the Cowtapult while they are 'working'.
World of Warcraft: Limited Free to Play Adopted
News & Features Discussion « General Discussion
I was 'almost' ready to finaly give WOW a try. A nice slow 20 levels to feel out the game..sounds good so far.
What completly turned me off was the req. that I buy base, 3 expansions to stay in the game.
Not a chance ! If I liked the game I would buy the first campaign and if I got into it ( most seem to ) I would gladly buy the following editions. Truth is, 20 levels would be nice but NOT enough to commit to an $80 plus layout.
Hmm..GW2/ Skyrim anyone?
Guild Wars 2: ArenaNet Studio Tour
News & Features Discussion « General Discussion
Just waiting untill they are ready...I sure am!
Arenanet looks like a great place to work...and make a great game. Can't wait !
Why every race should be able to play every class
General Discussion « Star Wars: The Old Republic
I think the early MUDs had it right. Any race could choose any class but some races were better suited to some classes.
Giants didn't make good mages. They had low int and poor mana...BUT...since Draconian spells were based on health they could hit for a ton..just not very often. Elves were good mages because of high int and mana but were not very good warriors. Low Str and health...BUT..they had great dex and dodges.
Alot like life...we all have out stong and weak points.
Guild Wars 2: Eric Flannum Talks Engineers
News & Features Discussion « General Discussion
Kinda glad to see tech has progressed in the 250 years that have passed since GW1.
I wouldn't want to see a tech advance like the earth has made ( no WMDS please) so I'm thinking the Engineer is perfect and still preserves the feel of the game. Looks to be one of those jack of all profs.
Guild Wars 2: Arena.Net Reveals the Engineer
News & Features Discussion « General Discussion
This looks like a great crowd controll character...with teeth.
Guild Wars 2: Environment Art
News & Features Discussion « General Discussion
I love these 'apetizers' and always enjoy them. Can't wiait for the main course !
There is a series of conversations and a story available in the blog to..very well done. Here's the starter... Big City + Stranger Things + Etc.
Guild Wars 2: The Quiz: The Guild Wars 2 Edition
News & Features Discussion « General Discussion
Knew them all ( to lazy to look again and list prices).
I think I'm spending tooo much time looking at GW2 !!! ....Naaaa
General: A Hello and a New Column
News & Features Discussion « General Discussion
Thier resume 'appears' thin because you know little or nothing about them.
They have been involved with both gaming companies and product manufacturers..who respect them.
If anyone truely wants to know it only takes a few minute to collect info on the guild. {mod edit}
General: A Hello and a New Column
News & Features Discussion « General Discussion
Did you actualy read the piece? If so you must have seen the following statement made by Sean:
By no means do I profess to have the "only" view on a topic and I would welcome debate, counter-ideas and differing viewpoints and with the vocal readership at this site.
Sounds pretty reasonable to me. How about a viewpoint regarding the issue? {mod edit}
{mod edit} It takes something very special to do what the Syndicate has accomplished.
Oh yeah, the issue...its about gaming in general and could be an interesting topic.
I'm in a 5 year old guild that seems to be drama free and its great. I used to form a guild of one to avoid guild spam.
If and when you find a good guild it becomes more than just a bunch of names. Help is freely given for both gaming and rl issues, tech info, new games on the horizon...lots of great stuff :) and it can definetly make any game more fun. I actualy got to know people which makes a huge difference. I say this as primarily a solo player that has very much enjoyed both getting, and giving help to a guildy that I know from the guild forums.
Welcome aboard Sean. Here's hoping more people start reading and responding to issues.
General: The Economics Of Gold-Farming
News & Features Discussion « General Discussion
In an odd way the number of gold sellers is directly in line with how well a game is doing.
Large player base= more potential customers.
For those who think the gold farmers ( the players...lil guys) should just move to the US and make big $$. It costs several thousand dollars to make the trip. Then you need a place to stay, food and have a language barrier to deal with. Not easy in a country with a large unemployed percentage of the workforce out of work to begin with.
General: The Syndicate Gives All to F2P
News & Features Discussion « General Discussion
Originally posted by Loktofeit
Well said. Unfortunatly when people see things they can't hope to achieve they atack and demean them.
C'mon people! Who wouldn't be proud of having a guild this large thats been around as long and is used by gaming producers to test games????
FYI, they don't 'go after 'anyone' using thier name but if someone is acting like they are the real deal and are behaving poorly they will go after them to protect thier name. Read a little on the site and maybe that will help explain the purpose of copywriting.
Once again there are a group of people who claim 'lots' of guilds have been around longer but never a mention of who they might be. The who should be one with a web site and not a name that has been reused several times over the years.
Grats to Dragons and the Syndicate for being the oldest continuously operated guild and wow...it must be great to be involved in working with games in pre-pre beta and learning what goes into a game.
General: The Quiz: Hype Edition
News & Features Discussion « General Discussion
Never NEVER use Wiki for a factual account. Nothing there is vetted and while most pieces are acurate the lack of vetting makes them unreliable unless there are credible refs that back up the story.
I have a friend that works for a newspaper who recently told a story about a manager who did a story based on Wiki info. The facts he stated were very wrong. He was fired.
General: MMORPG.com PAX East Panel - Part 4
News & Features Discussion « General Discussion
Originally posted by S00S00
Keep in mind that many smaller studios never get past that 1st MMO. A larger studio and larger budget have larger investors who aren't willing to take a long shot with their $$$. Failing for these investors pretty much guarantes you are now a small studio and will find it very hard to attract the big $$$ needed for a serious MMO in the future.
Guild Wars 2: The Final Two
News & Features Discussion « General Discussion
Originally posted by DraganBlack
Very much agree with #1, Mesmer/ Illusionist class.. As mentioned they are in the storyline and the Queen is/was a Mesmer. Its just to good a class to drop. Light armor works here :)
#2 not a clue but an engineer type could be interesting.
I don't realy care what both classes turn out to be....as long as one is a Mesmer type.
General: The Syndicate Update
News & Features Discussion « General Discussion
Originally posted by Banegrivm
Oh? name a couple that have been around longer AND without break that does this.
I see many claims of guilds that have been around 'alot' longer but never a mention of who it was. Include a website please. Any guild that has been 'around' this long would have a site..no?
Also consider that to be around and as active as The Syndicate there needs to be some sourse of revenues. Being able to do more than the (above) average guild doesn't happen free.
General: The Syndicate Update
News & Features Discussion « General Discussion
Originally posted by Mysticum
Whew !! You miss the point. The Syndicate TRUELY care about its members and is very involved in the gaming world. Thats why they are where they are and have lasted so long.
FYI, they are also involved in community work as a guild and have yearly gatherings. Very very few guilds do that and none have been so successful.
General: The Syndicate Update
News & Features Discussion « General Discussion
I actualy read the book and enjoyed it. Seems the guild is involved in alot more than just gaming.
Why all the complaining? Is it just sour grapes? Anything to successful seems to come under attack here.
Complaining about a guild that has been going strong for as long as Syndicate has seems to be the norm. Gripe about success???
I'd rather see a group of experienced players giving advice that a bunch of payers with ??? gaming exp.
Think its no big deal?? Easy?? Go for it...
The Secret World: The Classy Classless System
News & Features Discussion « General Discussion
Some muds allowed a charater to have all the skills in the game. Aardwolf was one that did a great job. Its still going strong and growing. To get all the skills there was 7 series of levels (1-201/level) where one of 5 classes was chosen for the forst 5 and 2 with full power. Then you went on to the second tier...up to 7 when I played. Great fun and since everyone had the same oportunity it worked.
GW1 also allowed a character access to all skills but only 2 classes could be used at any time. There were constant rebalances ( Anet was realy on top of it) . Even with the limitation there were many combos that no one could have possibly considered initialy. The result was some Godmode combos and builds that could do some amazing things. Godd old Sabway, Doscordway and the 55 hp monk/Necro combos were great and are still possible. Some others were just tooo strong for farming and were nerfed. There seemed to be a new 'meta' every few weeks for a while.
It is nearly impossible for a 'classless' system to not have unforseen developments and majot balance issues. I prefer balanced classes where I have to know both my class and the one I am up against to win.
time will tell. Prolly be fun :0
General: The Quiz: Top Rated Games Edition
News & Features Discussion « General Discussion
gasp 1st got 5


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Civil War Sesquicentennial
On April 12, 1861, decades of sectional turmoil focusing on the fate of slavery came to a violent head as Confederate guns bombarded Fort Sumter. For the next four years, armies of Americans clad in blue and gray savaged eachother in a contest that would determine the fate and future course of our nation.
The Battle of Stones River was one of the key moments of the Civil War. The bloody Union victory near Murfreesboro, Tennessee affected thousands of people's lives and changed the military, political, and social course of the war.
The park will present a number of special programs and events throughout the 150th anniversary of the Civil War that will highlight the role of the Battle of Stones River and other Civil War events in middle Tennessee that shaped the course and outcome of that conflict.


text:
Impending Tina Fey Backlash?
After Tina Fey and 30 Rock sweep the Emmys, Portfolio estimates the bespecaled writer/actress has pulled in at least $17 million. Could this, the actress' departure from SNL, and those annoying American Express commercials lead to a serious backlash?
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text:
The Valentia Fixed Side Convertible Crib surrounds your little darling in comfort and style with this beautiful, sleigh designed crib. Curved edges, flowing lines and a gorgeous white finish create a crib that even royalty would adore. With secure, static side rails and an adjustable one piece mattress support base, this piece provides crucial stability and function. This crib is not only delightful, but it is a smart investment; converting from a standard crib to a toddler and daybed, but ultimately into a full-size bed complete with headboard and footboard (full size bed rails not included). Set-up this royal piece with ease by following the simple, easy to follow assembly instructions provided by Stork Craft. Complete your nursery look by adding a Stork Craft changing table, chest, dresser or glider and ottoman.
Product Features
- Available finishes: white, cherry, espresso, black, cognac, oak
- Designed with safety in mind as it meets current U.S. and Canada safety standards
- 4 in 1 Fixed Side Convertible Crib: converts from a full size crib to a toddler bed, to a daybed, to a full-size bed (full size bed rails not included)
- Solid stationary sides offer security and stability to last a lifetime
- Three mattress-support positions to accommodate your babies growth
- Matching accessories: a changing table, chest, dresser or glider and ottoman
- Solid wood and wood product construction
- Easy to assemble with permanently attached instructions
- Product Dimensions: 50.5" (H) x 29.5" (W) x 60.8" (D)
Additional Information
|Storkcraft Baby
|Shipping Time
|Shipping Restrictions
|This item can not be shipped to APO/FPO addresses.
|Shipping Note
|Products ship in their original packaging. Please be aware that its contents will be visible to the recipient upon delivery.
|Car Seat
|Seat Color
Customer Q&A
Anonymous asked: Where is this crib made?
Staff Answer: Hello and thank you for your inquiry! This particular crib is made overseas for instance China or Vietnam. The manufacturer does not ship by country of origin. I hope this helps!
You may also be interested in the following product(s)
Schoenhut 37 Key Concert Grand
Orbelle Lisa Fullsize Folding Crib
Orbelle Sleigh Crib
Oggi® Elevation: The Complete Body Positioning Pillow System


text:
Fellow Inmates, help a newbie get his bike running good, pleasssee.
View Single Post
Joined: Mar 2011
Location: Silver Spring, Md
Oddometer: 10,203
Close but no cigar. You named them correctly. The short version, Idle Mix Screw (the little one) is one turn Out, Idle Speed Screw (the big one) is one turn In.
A longer version. The idle mix screw is regulating the amount of gas the idle circuit carries. The more out the screw is the richer the mixture will be at idle. For an R90/6 the official starting place for the little idle mixture screw is one turn out. You may adjust this some but don't do that at first till you get the speed closer to what it needs to be. Set the idle mix at one turn out. This is the adjustment in the Bing manual for all R90/6es.
The idle speed screw provides a stop for the butterfly so it doesn't close all the way. It holds the butterfly open a very tiny amount. The two carbs are balanced with the idle speed screws. They need to be even in the sense that the two cylinders are running at the same speed and pulling the same amount. That is why it is called "balanced". Set the idle speed screws in one turn from the moment they first contact the bell crank of the throttle shaft. This is hard to do when the carbs are on the bike, the screw and the part it contacts are on the back side of the carb, so it's just hard to do. You want to try and set the speed screws to ONE TURN IN.
The Mix Screws ONE TURN OUT.
You need a method of balancing the carbs to get these settings even between the two sides. I'll ask again, Do you have the shorting rods or a manometer or other tool that compares carb vacuum so you can balance the carbs?
Never memorize something you can look up.
---Albert Einstein
Pay your debt, piratejohn.
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text:
I suppose that I share a lot of the same sentiments on the subject as Jeff Atwood
over at Coding Horror.
About a month ago, I added Google AdSense (at the suggestion of my good friend
Keith Elder). I've tried to keep the ads
relatively low key in order to keep the clutter down. That doesn't result in as
many clicks as it might if I threw them in your faces, but I'm OK with that. I like
to keep my layout clean for those who do come in via the web (and not just the
The truth is, I don't trust Google AdSense all that much. Context-sensitive ads
are great, but they aren't always accurate. For example, I've mentioned the word "Haskell"
several times in reference to the pure functional programming language,
Haskell. However, the very use of this relatively
uncommon word has triggered Google Ads for the
Haskell Indian Nations University.
Sigh. It's really hard to get behind advertised products when you're not 100%
certain that they'll be relevant to your content.
Recently though, I found a product that I can whole-heartedly recommend. It's a
product that falls directly into my demographic of humor-loving,
technology-lusting geeks: RiffTrax.
What's RiffTrax you ask? Well, do you remember the TV show
Science Theater 30001? That's right. The one with the guy and the robots and
the making fun of old B-movies. Well, RiffTrax is that without robots and with
blockbusters instead of B-movies. It still has the guy though. In fact, it's the
same guy from MST3K.
In essence, RiffTrax are feature-length commentaries in MP3 format that you
can purchase, download and sync to your DVDs. Some RiffTrax feature stars and
writers from MST3K, and some even have celebrities joining in
on the fun. For example, my current favorite is a riff on
Jurassic Park that
features none other than Weird Al Yankovic.
Pants-wettingly hilarious. Seriously.
Below is a small sampling of the films that have received the RiffTrax
treatment. There are lots of others. Some have
Jar Jar Binks. Some
have Keanu Reeves. All
will make you howl with laughter.
Honestly, I don't think of this as advertising. This is a
service announcement. You need this. I promise.
1Some may have missed out on the delights of Mystery Science Theater
3000 (MST3K). You can catch up here.
If you're just joining us, below is the path that has brought us to this
Today, we're taking a high-level look at F# option types. Option
types are a simple example of a discriminated (or tagged)
union1, although understanding that isn't necessary in order to use them. Simply put, an option type wraps
a value with information indicating whether or not the value exists. For C# or VB programmers, it
may be convenient to think of option types
as a mutant cross between
.NET 2.0 nullable types and the
null object design
There are two constructors that instantiate option types. First,
there's the Some
constructor, which takes a value to be wrapped.
And then, there's the None constructor,
which doesn't take anything.
One of the properties of option types that makes them so compelling is the
ability to pattern match over them.
Now, we can call our isFortyTwo
function to show that the pattern matching works as expected.
This is all well and good, but we need a practical example to sink our teeth
into. Let's use the .NET Framework
Stream.ReadByte function as a guinea pig. ([ed.] Dustin is not
implying that you should sink your teeth into guinea pigs. That's disgusting.
Shame on you.)
Stream.ReadByte has a pretty bad code smell. First of all, it returns
an int instead of a byte. Initially, that should seem strange since the method
specifically states that it's a byte generator.
returns -1 when
the current position is at the end of the stream. Because -1 is not expressible
as an unsigned byte, ReadByte returns an int. Of course, that's the second problem:
extra non-obvious
information is encoded into the result value of this function. However, unless you read the documentation, there's no way of knowing
By employing an option type, we can clarify the function and be a bit more honest about
its result.
Now, the semantics of the function are better expressed thanks to the option
In addition, we can write a function that pattern matches over the result of our readByte function.
And here's the above printStream
function in action:
Option types provide an elegant way to attach a bit of extra boolean information
to a value. It's important to become comfortable with them as they are
used extensively throughout the F# libraries.
Have fun! Next we'll explore... well... I haven't decided yet. If you have
any suggestions, feel free to email me at dustin AT diditwith.net.
1We'll explore discriminated unions in a future article.
I don't know about you, but around my house, computer books have a habit of multiplying like rabbits.
Sometimes it seems as if you can't put up your feet without resting them on a
pile of old programming books. There are several reasons why these books proliferate
Because my shelves are bursting at the seams (and the Wife Acceptance Factor
for them has become quite low), it's time for an early Spring
cleaning. If you're interested in some reasonably-priced programming tomes,
previously owned by a lesser-known blogger, feel
free to browse my
Amazon storefront.
(Quiz: How many of the books in above picture do you own?)
(Clarification: The books pictured above are not for sale. Those are keepers!)
Pattern matching is a simple idea. Essentially, a pattern match takes an
input and a set of rules. Each rule tests the input against a pattern and
returns a result if they match.
The following naive implementation of the
tired, old
Fibonacci function shows simple pattern matching at work.
Pattern matching syntax is simple and clear. It should be readable by any programmer worth
their salt. In fact, the above
match .. with
block is completely equivalent to the following C#
switch statement:
That's pretty unimpressive. I mean, if pattern matching were identical to
standard switch statements, there really would be nothing exciting about them. Fortunately,
there are some enormous differences that demote switch
statements to a very distant cousin.
The first difference is subtle but profound: pattern matches return values. A
pattern match is very much like a function that takes an argument and returns a
value. Consider the following rewrite of our F# fib
The above example might be a bit contrived, but it illustrates the point. Simulating that with a
switch statement is awkward.
Switch statements don't return values, so we can't assign a switch
statement to a variable. Instead, we must use mutable state and pepper the cases
with break statements.
In essence, a pattern match is like a function while a switch statement is like
a big
In addition, pattern matching supports a wealth of features that truly set
it apart from standard imperative switch statements.
Patterns can:
Let's examine each of these in turn.
First, consider our original fib
function with an additional pattern containing a guard rule:
Now that's a bit more interesting! In C# or Visual Basic, we would have to
introduce an if-statement at the beginning of the function to test for an
invalid argument. In F#, the guard is inserted directly as a pattern rule.
Another indispensible feature of F# pattern matching is the ability to bind
values to names.
So far, we've used the match .. with syntax
to define pattern matches. This time, we'll use an alternative syntax that,
although it is not required, easily demonstrates how values can be bound to names within pattern rules.
The alternative syntax can be used in the case where a function is defined
with one argument and simply returns the result of a pattern match on that
argument. In this syntax, the argument is not specified, and the keyword function is
The match .. with
statement needs to reference the argument name, but because the argument is
unspecified, it has no name. Consequently, the match .. with
statement must be removed, leaving us with a function that is defined entirely in terms of
pattern matching rules. Because the argument is unnamed, values must be bound to
names within the pattern rules.
A code sample is worth a thousand words.
In the above code, we bind the name x
in each pattern to make up for the fact
that the argument is unspecified. In addition, the rules for 0 and 1 and have been
combined using an "or" (or "union") pattern. Note that there
are two different ways to bind a value to a name within a pattern rule. First, a
name can simply be explicitly specified, substituted within the pattern. The other way is to use the as keyword.
Both ways are demonstrated above.
The last feature of pattern matching that we'll look at is its capability to
decompose type structures.
we saw that F# would automatically convert the result of
TValue>.TryGetValue to a
tuple if a
variable isn't specified for the out parameter. In a
comment to that
article, Derek Slager presented a
helper function that returns a default value if TryGetValue
returns false. This helper function is an excellent practical example of a
pattern match that decomposes a tuple value.
In addition to the tuple decomposition, the first rule elegantly binds the second
part of the tuple to the name value.
Because pattern matching is intrinsic to F# programming, we'll see more of it in upcoming articles. As features
supporting pattern matching are introduced in this series, we'll build on
the basics presented here.
Next up: the option type. See you then!
Page rendered at Thursday, July 02, 2015 11:54:05 PM (Pacific Standard Time, UTC-08:00)
If feel a bit behind and need to catch up on WPF, this is the book.
Great book on F# containing from Beginner to Advanced. It even has chapters on more arcane features of the language, such as Computation Expressions and Quotations.
Because this book provides source code in Standard ML, it's a fantastic
resource for learning F#. One bit of warning: this book does not teach classic
data structures. While structures such as binomial heaps and red-black trees
are presented, it is assumed that the reader already knows and understands
The opinions expressed herein are my own personal opinions and do not represent
my employer's view in any way.


text:
Pork Chops Cacciatore
20 Nov 2011
|Pork chops
|6 (rib or shoulder)
|Bermuda onion
|1 , cut in 6 slices
|Brown sugar
|2 Tablespoon
|Spaghetti sauce mix
|1 Ounce (1 envelope)
|Canned tomatoes
|2 Pound (2 cans, 1 pound each)
1) In a pan, add pork chops and brown well.
2) Arrange in single layer in shallow 8-cup baking dish.
3) Over each chop, place an onion slice and sprinkle with brown sugar.
4) Add the spaghetti-sauce mix into the pan drippings and stir in the tomatoes.
5) Stirring continuously, heat till the mix boils.
6) Spoon the mix over the chops and onions and place a lid over.
7) Place in oven at 350° for 1 hour, uncovered.
8) Bake for another 15 minutes, till the chops are tender.
9) Arrange the chops in a heated serving platter.
10) Top with sauce and serve with garlic bread.
Recipe Summary
Difficulty Level:Medium
Course:Main Dish
Preparation Time:30 Minutes
Cook Time:75 Minutes
Ready In:105 Minutes
Rate It
0 Comments
Pork Chops Cacciatore Recipe


text:
Originally written on Hoop Fantasies Fantasy Basketball Blog | Last updated 2/21/13
Kawhi Leonard is resting his knee Thursday night. The Spurs' injury report says Leonard is only expected to miss tonight's game with the Los Angeles Lakers. So whatever is ailing Leonard must not be serious, and this sounds like Greg Popovich giving one of his starters some rest. Look for Danny Green to get all of the time he wants. He's on a roll, averaging 14.3 points, 3.1 rebounds, 2.1 assists, 1.9 steals and .8 blocks in his last 10 games. And the highlight is a ridiculous 33 3-pointers made in that span. Injury report: Coach Pop said at shootaround Kawhi Leonard will sit out tonight (knee). Leonard only expected to miss tonight's game. — San Antonio Spurs (@spurs) February 21, 2013 Photo: Spurs' Twitter.
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text:
1985 Audi Quattro for saleNew arrival - coming soon!... More
1984 ALFA ROMEO VELOCE DELUXE ROADSTER INCREDIBLE CONDITION! ONLY 7,886 ACTUAL MILES! ONE OWNER FROM NEW! FULL DOCUMENTATION, INCLUDING OWNER'S MANUAL, MAINTENANCE BOOKLET, ORIGINAL TOOLS, JACK & MORE! TOP... More
We offer an outstanding perfect Ferrari Testarossa from 1985. It is a very rare "Monospecchio" model which means with one mirror on the left... More
PRICE IN EUROS : 210000,- Perfect series 1 Ferrari Testarossa Monospecchio Monodado with only 66,000 km!! Original in Germany delivered and features the original... More
1985 Pontiac Firebird T-RoofLow milesRear spoilerAM FM radio with tape playerOne ownerNon-smokerAll originalAlways garagedNever driven in winterT-roofRuns like new no accidents all scheduled maintenance... More
Offered for sale is an absolutely striking, extremely original, mechanically excellent 1985 Porsche 911 Targa with only 42k original miles from new. Finished in... More
~CALL US FOR A DETAILED DESCRIPTION OF THE CAR! WE DO A 150+ POINT CHECK ON EACH VEHICLE AND ARE HAPPY TO SHARE... More
Original km , all owners manual and book service.... More
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There is perhaps no more widely recognizable or iconic car than the Lamborghini Countach. Much has been written about the car, sometimes positive, sometimes... More
Rare and sought after European Market 930 Turbo 3.3L Turbocharged Flat-Six 330HP All Steel Slantnose Conversion Matching numbers engine and turbo Recent major service with receipts Recent correct red leather interior Gorgeous... More
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For sale in our Detroit showroom is this very clean 1985 Ford Mustang GT. This very low mile car is still on its second... More
Beautiful 1985 Porsche 911 Carrera in great condition inside and out! This 911 is presented in a White exterior with a sleek Blue Leather interior. Financing... More
1985 Porsche 911 Targa, 76K same owner since the 90's. Persian blue with blue interior. Fresh service just completed by Master Porsche tech. See it... More


text:
Home - Ambush Printing
Ambush Printing is a rare document company specializing in museum quality manuscript reproduction.
Specializing in the Voynich Manuscript and Leonardo Da Vinci
Contact Us
Masters of science. Da Vinci, Isaac Newton
Voynich Manuscript
Books Of Hours
Gutenberg Bible
King James Bible 1611 Version
At Ambush Printing we are experts at making museum quality manuscript reproductions.
, Mesa, Arizona


text:
Could they really be expected to 'live off the land', hoping to stumble upon some isolated human outpost every night?
Unless Romney badly stumbled, there was not going to be room for Huntsman—and Romney did not stumble.
Afterward, stumble out into North Beach and walk it off on a stroll down to the Wharf.
c.1300, "to trip or miss one's footing" (physically or morally), probably from a Scandinavian source (cf. dialectal Norwegian stumla, Swedish stambla "to stumble"), probably from a variant of the Proto-Germanic base *stam-, source of Old English stamerian "to stammer," German stumm "dumb, silent." Possibly influenced in form by stumpen "to stumble," but the -b- may be purely euphonious. Meaning "to come (upon) by chance" is attested from 1550s. Stumbling-block first recorded 1526, used in Rom. xiv:13 to translate Greek skandalon.
verb phrase
To cast or record fraudulent votes in an election (1854+)


text:
ILLUMINATE: A Martial Arts Experience is a unique live martial arts show. Some say it's Karate Kid meets Star Wars. Other say it's a karate rave. ILLUMINATE showcases martial artists who strike, dodge, jump, break, and battle in the dark with LED equipment.
A team of black belts perform advanced fight choreography, weapons battles, group demonstrations, and dangerous self-defense techniques. All of the action is enhanced with special equipment used to artistically show martial arts in a way you've never seen before. The show features an all-original musical score, created especially for ILLUMINATE. Parts of the show even include live drumming using glow-in-the-dark drum sticks. With cool lighting effects, expert martial arts, and original music, ILLUMINATE is a show you must see for yourself!
Note: The special lighting effects cannot be accurately captured by any video camera — this is something you have to see firsthand to truly appreciate! For another attempt at capturing the show, explore our photo gallery.
ILLUMINATE: A Martial Arts Experience performs at limited engagements and is available to be booked at your special event. To inquire about booking, please send an email to firstname.lastname@example.com.
This production was original presented as part of the 2011 Capital Fringe Festival. A program of the Washington, DC non-profit Capital Fringe.


text:
Hosanna, Rejoice and Sing!
By Jane Holstein
Hosanna, Rejoice and Sing! arranged by Jane Holstein. For SATB choir with optional handbells. Hymntune, Call To Worship, Holy Week, Palm Sunday, Sacred. Octavo. 8 pages. Published by Hope Publishing Company (HP.C5454).
For Palm Sunday, this triumphant introit sets a festive mood as the Call to Worship, based on two familiar hymns: "Rejoice, Ye Pure in Heart" and "Hosanna, Loud Hosanna." With the optional use of handbells and either piano or organ accompaniment, this SATB choral setting prepares the worshiper to "rejoice, give thanks and sing!" The 2-page bell part is included.


text:
AS A SOPHOMORE IN 2014Did not compete.
AS A FRESHMAN IN 2013Ran in five races and contributed points in four races ... Made collegiate debut with a sixth place finish and fifth team finisher at the UC San Diego Opener with a time of 16:05.4 ... Was Triton's fifth finisher at the NCAA West Regionals with a 96th place finish (24:21.5) ... Finished in 27th place and Triton's fourth finisher at the CCAA Championships with a time of 23:04.0.
HIGH SCHOOLA 2013 graduate of Point Loma High School in San Diego ... Holds school records in the 800 meters (2:17) and the 1600 (5:02).
PERSONALBorn Sept. 5, 1995 in San Diego ... Parents are Robert and Laura Verhees ... Has two younger brothers named Mason and Julian ... Is enrolled at Muir College as a human biology major ... Would like to become an orthopedic surgeon ... Hobbies include soccer, swimming, and surfing ... Django Unchained is her favorite movie ... Listens to The Kooks ... Mangoes are her favorite food.


text:
Brewers tie up Pirates in 8th
Brewers tie up Pirates in 8th
The older I get - the better I was
and yes - I hate the Cardinals (Reds fan since 1958)
Last edited by Matt700wlw; 09-03-2013 at 10:54 PM.
Make a statement, win one of the next 2.....
Complete a sentence, sweep 'em
Goold and Joe Strauss are both trolls. A lot of the Cardinals current players are somewhat likeable, its their fans and writers I can't stand.
I miss Adam Dunn.
lead did not last long --- 4 - 3 Pitt in 9th
The older I get - the better I was
and yes - I hate the Cardinals (Reds fan since 1958)
The older I get - the better I was
and yes - I hate the Cardinals (Reds fan since 1958)
Roy Tucker (09-03-2013)
Saw Rick Derringer when he was with an Indiana band called Rick and the Raiders.he was Rick Zehringer then. They played on the flatbed of a truck in a grocery store parking lot in a battle of the bands in Centerville.
Teach tolerance.
"You only have to bat a thousand in two things; flying and heart transplants. Everything else you can go 4-for-5."
-Beano Cook
Board Moderators may, at their discretion and judgment, delete and/or edit any messages that violate any of the following guidelines: 1. Explicit references to alleged illegal or unlawful acts. 2. Graphic sexual descriptions. 3. Racial or ethnic slurs. 4. Use of edgy language (including masked profanity). 5. Direct personal attacks, flames, fights, trolling, baiting, name-calling, general nuisance, excessive player criticism or anything along those lines. 6. Posting spam. 7. Each person may have only one user account. It is fine to be critical here - that's what this board is for. But let's not beat a subject or a player to death, please.


text: Sports Illustrated April 11, 1955 magazine. This copy is in excellant condition, and includes the uncut and still attached page of 8 - 1955 Topps cards. Does have a label, but has absolutely no rips or tears. The uncut sheet of Topps cards includes Ray Jablonski, Dusty Rhodes, Danny Schell, Wally Moon, Warren Spahn, Karl Spooner, Dick Groat, and Ernie Banks. The center page has been detached from the staples, but all other pages are firmly in tact.


text:
Cowboys linebacker Rolando McClain made his presence felt in his return to the lineup on Sunday night. Read »
Jerry Jones believes Morris Claiborne still has a bright future in Dallas. Read »
Anthony Spencer recorded three tackles in his long awaited return to the lineup on Sunday night. Read »
After a three touchdown performance Sunday night against the Saints, Tony Romo believes he's getting close to being 100 percent again. Read »
Amobi Okoye believes he'll be ready to go when he's eligible to come off the non-football injury list in Week 7. Read »
Jerry Jones said Sunday night that Josh Brent's suspension had been modified so that he'd be permitted to return to Valley Ranch on Monday. Read »
DeMarco Murray became just the fourth running back in history to open a season with four consecutive games with at least 100 yards rushing and a touchdown. Read »
The Cowboys fear that cornerback Mo Claiborne suffered a torn ACL in the first quarter of their Sunday night win over the Saints. Read »
Bruce Carter was a forgotten soul last season, but so far this year he's been pretty good. The Cowboys got what seems to be good news Sunday night on what was originally thought to be a bad injury. Read »
Images from the sideline at AT&T Stadium where the Dallas Cowboys beat the... See Full Gallery »
Get the latest news about the 5-Time World Champion Dallas Cowboys


text:
The Boivin Center has enjoyed a very successful 30th anniversary year beginning with "Made in France," featuring noted art historian, Laura Morelli, continuing with the soulful sounds of Eric Vincent as he serenaded us in concert, to the outstanding lecture and superb gourmet dinner with the very personable Jacques Pépin, to the uplifting story of survival in Nazi occupied France of Sarah Lew Miller's family to the humorous depiction of life in France by the greatest living children's author, Mo Willems.
We are already planning future events for the fall to continue the mission of Omer Boivin to cultivate knowledge and appreciation of the French language and culture.
Please check back with us in the coming weeks and mark your calendars to join us at our future events.
Merci et bonnes vacances!
Past events
Illustrious individuals who have honored the Boivin Center with their presence
- 1986: Alice Parizeau, Lucie Therrien
- 1988: Jean-François Somain
- 1989: Roch Carrier, Roger Violette, Omer Boivin, Lois Pines
- 1991: Pierre Capretz, Dr.Gaëtan Brulotte
- 1992: Brian Thompson, Gérard Le Tendre, Jacques Borel
- 1993: Naïm Kattan
- 1994: Alice Dawn, Albert Coté, Maxime LeForestier, Serge Kerval, Richard Wilbur, Peter Sandler
- 1996: Dr. Madamou Soumaré, Normand Demers, Jacques Parizeau
- 1997: Frederick Wiseman, Annie Royer, Patrick Noe, Misha DeFonseca
- 1999: Nicole Brossard, Helene Dorion, Francine du Plessix Gray
- 2000: Julia Child
- 2001: Pierre de Boisdeffre, Stephane Chemlewsky, Frédéric Martel, Lisa Gossels
- 2002: Anne-Christine Rice, Le Grand Dérangement, Marie-Claire Blais, Senator Paul Simon
- 2003: Prof. William Carter, Marcel Marceau, Polly Platt, Maia Weschler
- 2004: Prof. John Rassias, Prof. Adam Braver, Véronique Mistycki
- 2005: Prof. Emmanuel Dongala, David Plante
- 2006: Prof. Patrick Henry, Richard Hétu
- 2007: Claudia Hommel, Bob Moreen, Jean-Claude Baker
- 2008: Sophie Freud, Frédérique Hébrard, Louis Velle
- 2009: Florence Delay, John De Mado
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Comprehensive description of the behavior of cellular components in a quantitative manner is essential for systematic understanding of biological events. Recent LC-MS/MS (tandem mass spectrometry coupled with liquid chromatography) technology, in combination with the SILAC (Stable Isotope Labeling by Amino acids in Cell culture) method, has enabled us to make relative quantitation at the proteome level. The recent report by Blagoev et al. (Nat. Biotechnol., 22, 1139–1145, 2004) indicated that this method was also applicable for the time-course analysis of cellular signaling events. Relative quatitation can easily be performed by calculating the ratio of peak intensities corresponding to differentially labeled peptides in the MS spectrum. As currently available software requires some GUI applications and is time-consuming, it is not suitable for processing large-scale proteome data.
To resolve this difficulty, we developed an algorithm that automatically detects the peaks in each spectrum. Using this algorithm, we developed a software tool named AYUMS that automatically identifies the peaks corresponding to differentially labeled peptides, compares these peaks, calculates each of the peak ratios in mixed samples, and integrates them into one data sheet. This software has enabled us to dramatically save time for generation of the final report.
AYUMS is a useful software tool for comprehensive quantitation of the proteome data generated by LC-MS/MS analysis. This software was developed using Java and runs on Linux, Windows, and Mac OS X. Please contact email@example.com if you are interested in the application. The project web page is http://www.csml.org/ayums/ webcite.
The LC-MS/MS system is one of the most frequently used instruments for shotgun protein identification [1-6]. Protein identification by LC-MS/MS analysis consists mainly of the following five steps: (i) The samples are prepared from protein mixtures by peptide fragmentation with a protease, e.g., trypsin. (ii) In the LC column, the digested peptides are separated according to their hydrophobicity and/or polarity (iii) In the survey scan (MS-1) mode, the peptides eluted from the LC system are continuously introduced into the mass spectrometer by electrospray ionization (ESI). (iv) The detector in the MS-1 mode separates peptides according to the mass/charge ratio (m/z) and selects the peaks with high intensity. (v) In the MS/MS (MS-2) mode, the selected peptides are separated from other components and randomly fragmented by physical impact. The detector integrates the intensity of each fragment, leading to the generation of MS/MS spectra.
Recent development of quantitative proteomics technology has made it possible to perform quantitative analysis of large-scale proteome data generated using the LC-MS/MS system. SILAC (Stable Isotope Labeling by Amino acids in Cell culture) is one of the most effective methods for comparative analysis of the expression status of proteins among samples [7-10], including time-course analysis [11]. The SILAC method has undergone some modifications. One of the well-modified SILAC methods is as follows: (i) Target cells are incubated in three types of media, namely, media containing (1) natural arginine, (2) arginine containing stable isotope of 13C, or (3) arginine with two types of stable isotopes, 13C and 15N. (ii) The samples prepared from differentially labeled cells are mixed in equal proportions and introduced into the LC-MS/MS system. (iii) The peak derived from the same amino acid sequence is shifted in proportion to the difference of the number of neutrons between the samples. Relative quantitation can be performed by comparing the peak intensities of differentially labeled peptides [11].
The above method is widely used for describing various biological events [10-12]. For example, Blagoev et al. reported the global quantitative dynamics of phosphotyrosine-based signaling events by measuring the fold activation of related proteins at different time points [11].
Several types of software, e.g., SEQUEST [13], MOWSE [14], Mascot [15], ProteinProspector [16], and ProFound [17], have been developed for protein identification based on MS or MS/MS data. These software tools deduce a corresponding protein/peptide sequence from the measured data and generate a report with additional information, e.g. reliability score, gene ID, and modification if any. For quantitation, MZmine version 0.60 was developed for differential analyses of the LC/MS profile data [18]. Although this software uses a GUI interface with a powerful batch-processing function, its application is restricted to the analyses of LC/MS data. For further analyses using LC-MS/MS in combination with the SILAC method, MSQuant [19] has been developed. MSQuant has a GUI interface and runs on Windows OS. However, this software is not in stable operation and requires a huge memory (e.g., 2 GB) to run.
In the present study, we have developed a completely automatic console-based software tool that is highly customized for LC-MS/MS proteome data obtained by the SILAC method. Here we report a new algorithm for peak detection, details of the data analysis pipeline, and a new platform-independent open source software, AYUMS, developed using this algorithm. Furthermore, we compare the results obtained by manual operation with those obtained using this software and discuss the respective performances.
AYUMS consists of a series of steps for processing LC-MS/MS data. The scope of this software is focused on data processing for extracting quantitative information from the raw data. Therefore, other tools should be used for the statistical analyses based on the information produced by AYUMS. This software is implemented as a stand-alone Java application and requires JRE 1.4.2 or higher version. In contrast to MSQuant (which runs only on Windows), AYUMS is platform-independent, i.e., it runs on any of Windows, Unix, or Mac OS X. In addition, the generation of the final report is completely automatic.
Software design
Our aim was to develop a software tool that automatically executes the calculation of the peak ratios of differentially labeled peptides analyzed by LC-MS/MS. To achieve this, we adopted a console-based user interface (CUI). AYUMS requires two input files – an LC-MS/MS raw data file and a database search result file containing the information on the identified peptides/proteins. AYUMS generates an output report in a comma-separated value (CSV) format. The flow chart of AYUMS is shown in Figure 1 and the contents of the flow chart are described in the following sections.
Figure 1. Flow chart of AYUMS. The procedure for AYUMS is illustrated in the flow chart. It consists of four stages: Stage 1, generation of an MS binary file, Stage 2, parsing of Mascot HTML, Stage 3, analysis of the spectrum data, Stage 4, generation of the analyzed reports. Stage 3 is subdivided into five steps, as described above.
Input data style and conversion of the raw data file
In the first stage (Stage 1 in Figure 1), AYUMS requires two files, namely, (i) a Mascot HTML file and (ii) a binary file in our original format (ayums format). For generating the Mascot HTML file, a peak list file is first prepared from the raw MS/MS data file using ProteinLynx (Micromass, UK). This peak list is searched against the protein database using Mascot (Matrix Science, UK) and the output of the database search is saved as an HTML file. The binary file is generated by the following two steps: first, the MassLynx raw data are converted to ASCII style data using Databridge in the MassLynx package (the format is shown in Figure 2); subsequently, this ASCII data file is converted to the ayums format using the conversion functions in AYUMS. Using a Pentium 4 (3.0 GHz) processor, the total time required for the conversion from the raw data to the ASCII style by Databridge is 30 min to 1 h, and the time from the ASCII style to the ayums format by AYUMS is 3 to 6 h.
Figure 2. Example of an ASCII format generated by Databridge. Databridge generates an ASCII format from the raw data of LC-MS/MS analysis. The file comprises five blocks that start from the string FUNCTION 1–5. As shown above, the block that starts from FUNCTION 1 corresponds to the MS-1 raw data (#1), and the other four blocks correspond to the MS-2 raw data (#2). Each block has data on multiple spectra that start from the Scan (#3), which contains m/z values (#4), intensity values represented by integers (#5), and retention time of the LC (#6).
Parsing of Mascot HTML
The Mascot HTML file mainly comprises a list of inferred proteins and their peptides along with the information on the observed molecular weight, the calculated molecular weight, the difference between these two weights, probability-based Mowse score, p-value of the score, rank of the matched ion, peptide sequence, and MS/MS spectrum. In Stage 2, the Mascot HTML file is parsed to make these data available in AYUMS. The CyberNeko Java library developed by Andy Clark is used as an HTML parser [20]. If the XML format is implemented for the output of Mascot, an XML parser library will also be useful.
Selection of reliable proteins and their peptides
In Stage 3, every matched protein and the list of identified peptides under the defined conditions are extracted from the parsed results of the Mascot HTML data. The criteria for data extraction are as follows: (i) select protein/peptides with a Mascot score higher than a threshold value, (ii) select peptides in higher ranks than a threshold value. The default condition in AYUMS is set to select all the peptides with a score higher than 25 in the top rank.
Peak detection and computation
In Stage 4, the peaks corresponding to the selected peptides are searched from the raw data and the peak ratios of the differentially labeled peptides are calculated.
The following five steps are applied for each selected peptide.
Step 1
Based on the Mascot data of the selected peptide, the retention time at LC and the m/z value of the peptide are searched from the ayums format of MS-2.
Step 2
According to the information on the retention time obtained in Step 1, the nearest time point is searched from the ayums format of MS-1, leading to the acquisition of the spectrum corresponding to the target peptide.
Step 3
The spectra around this time point are sequentially searched. A specific algorithm, the details of which are described below, calculates a score for each spectrum and selects the best spectrum.
The spectrum consists of a set of peaks with each individual m/z value and intensity. All the intensities within a certain range of m/z value (default 0.1) from the target peak are integrated. Each peptide is differentially displayed in three distinct forms that are derived from three types of stably labeled arginine (12C14N, 13C14N, and 13C15N). According to the information in the Mascot result, the identified peptide form and its differentially labeled ones are specified in the spectrum based on the principle that the differences of molecular weight between 12C14N - 13C14N and 13C14N - 13C15N are 6Da and 4Da, respectively (Figure 3).
Figure 3. Example of a spectrum at MS-1. In the analysis using the SILAC method, three differential peak clusters are observed based on the mass difference of the stable isotopes introduced into the peptide sequence. In the above spectrum of a doubly charged peptide with an m/z value of 549.86, the highest 13C614N4-Arg peak was analyzed for protein identification. Each peak cluster contains some additional peaks that derive from natural isotopes.
In addition, as proteins/peptides are made of some natural isotopes, each peak is accompanied by sub-peaks which shift 1 Da and 2 Da in the spectrum. The intensities of these peaks are all integrated as the total quantity of the target peptide.
Step 4
The spectra adjacent to the best spectrum are recursively selected as long as the score ratio of the investigated spectrum to the best one is higher than a constant value (default 0.8), which we term the acceptable ratio. Based on the data of the acceptable spectra, the intensities for three types of differentially labeled peptides are independently integrated.
Step 5
Based on the result in Step 4, the average ratios of 13C14N and 13C15N to 12C14N and their standard deviations are calculated.
The procedure for Step 1 to Step 5 is described in the following algorithm.
n := 1.008665
r := 0.1
r2 := 5.000
r3 := 3
r4 := 10
r5 := -0.2
for s ∈ S: set of protein
for {(fi, ni, ci)|0≤i≤N} ∈ F(s): F is a function from a protein to the fragments of the protein, the scan number of the MS/MS experiment, and charge of each fragment.
(rms/ms, mzms) := Rms/ms (ni) : Rms/ms is a function from a scan number of the MS/MS experiment to the MS/MS retention time and m/z value of MS experiment; these can be obtained from the raw data.
(rms, nms) := Rms (rms/ms): Rms is a function from an MS/MS retention time to the nearest MS retention time and its scan number.
emax = 0, , mmax = 0, tmax = ()
for {m|nms - r3 ≤ m ≤ nms + r3}
(, Lrate,m) := sub(m, mzms, ci, fi): calculate the total intensities of a peak and its ratio in the spectrum.
if emax <Lrate,m
emax := Lrate,m, mmax := m
T = {tmax}
for {m|mmax + 1 ≤ m ≤ mmax + r4}
t = (, Lrate,m) := sub(m, mzms, ci, fi)
if emax × (1 + r5) ≤ Lrate,m
add t to T
for {m|1≤m≤r4}
t = (, Lrate,m) := sub(mmax - m, mzms, ci, fi)
if emax × (1 + r5) ≤ Lrate,m
add t to T
: is the ratio of the amount of the wild type to the 13C14N form.
: is the ratio of the amount of the wild type to the 13C15N form.
:= Standard deviation of {|0≤i≤N}
:= Standard deviation of {|0≤i≤N}
function sub(nms, mzms, c, f)
L = {(tm/z,j, pj)|0≤j≤M} := P(nms ): P is a function from an MS scan number to the set of m/z and its intensity values. This set can be searched from the raw data.
R := the number of arginine in f
if f contains 13C and does not contain 15N
else if f contains 13C and 15N
:= peakIntensitySet(, L, r, c)
:= peakIntensitySet(, L, r, c)
:= peakIntensitySet(, L, r, c)
Ltotal := select all (t, p) ∈ L with [ - r2 ≤ t ≤ + r2]
function peakIntensitySet(mz, L, r, c)
L':= select all (t, p) ∈ L with [mz - r ≤ t ≤ mz + r]
L'':= select all (t, p) ∈ L with [mz - r + n/c ≤ t ≤ mz + r + n/c]
L''':= select all (t, p) ∈ L with [mz - r + 2n/c ≤ t ≤ mz + r + 2n/c]
Results output
In Stage 4, AYUMS generates a report in the CSV file format, as shown in Figure 4. The contents of the report are also described in the legend for Figure 4.
Figure 4. The report style of AYUMS in the CVS format. The final result is generated on a spreadsheet. The rows that start from "*" indicate the information on each protein (designated as Protein row). The subsequent rows that start from "-" show the data on each peptide (designated as Peptide row). The first two rows of the spreadsheet are the headers for Protein row and Peptide row, respectively. The columns of "i/w" and the next "StDev" are common to both the Protein and Peptide row, indicating the intensity ratio of 13C14N to 12C14N and its standard deviation, respectively. Similarly, those of "hi/w" and the next "StDev" indicate the ratio of 13C15N to 12C14N and its standard deviation, respectively. The "#Peptide" cell in the Protein row indicates the number of peptides for quantitative analysis in AYUMS. The "Mass" and "Description" cells indicate the molecular weight and the gene definition of the protein, respectively; these two contents are also described in the Mascot result file. The "Score" cell in the Peptide row indicates the Mascot score for each peptide. The "Ret.Time," "charge," and "#R" cells indicate the retention time, the charge, and the number of arginine residues for each peptide, respectively. The "wild," "iso," and "high" cells indicate the integrated peak intensities derived from 12C14N, 13C14N, and 13C15N, respectively. The "#Spectrum," "from," and "to" cells indicate the number of integrated spectra, the beginning and the end of the scan numbers used for data acquisition, respectively.
Comparison of the machine operation with the manual operation
In order to evaluate the performance of the automatic calculation by AYUMS, we used three sets of time-series data on the phosphotyrosine-related proteome. A431 Cells differentially labeled with stable isotopes of arginine were stimulated with epidermal growth factor (EGF) for different time periods, followed by affinity-purification of signaling molecules with anti-phosphotyrosine antibodies. After direct digestion of the proteins, protein identification and quantification were performed by nanoLC-MS/MS analysis (nanoLC: Dina-2A [KYA Technologies]; tandem mass spectrometer: Q-Tof-2 [Micromass]). Figure 5 shows the activation profile of phosphorylated proteins with the top six Mascot scores (AHNAK nucleoprotein, EGFR, catenin, villin 2, alpha 1 type XVII collagen, and junction plakoglobin). Figures 5(a) and 5(b) show the results obtained by manual operation and by AYUMS, respectively. From the experimental data, 100 proteins were detected by database search against the RefSeq human protein database (NCBI). In the pre-process, our algorithm removed 62 proteins with a Mascot score less than the threshold (default; 25). The remaining 38 phosphorylated proteins were then quantified by manual operation as well as by AYUMS. As shown in Figure 5(c), the results obtained by these two methods showed good correlation (R = 0.890).
Figure 5. Comparison of the results obtained using AYUMS versus manual operation. The output performance of AYUMS and manual operation is compared based on the time-series proteome data of A431 cells stimulated with EGF. The observation points are 0 min, 1 min, and 5 min. The proteins with the top six Mascot scores were selected for the comparison. (a) 2D-Plot data of the output obtained by manual operation (x-axis: time, y-axis: fold activation of each protein). (b) 2D-Plot data of the output obtained by AYUMS. (c) The correlation chart of 38 phosphorylated proteins for 1-min and 5-min observation points between AYUMS and manual operation. The correlation coefficient was 0.890.
Although the results for some proteins did not correlate well (for example, the value for villin 2 obtained by AYUMS is lower than that obtained by manual operation), the shapes of the activation change between the two methods matched each other in most cases. It should be noted that AYUMS enabled us to eliminate the necessity for manual operation. In other words, reliable quantitation results were obtained in a high-throughput fashion that had never been achieved previously.
The poor correlation for some proteins was mainly due to the existence of noise peaks. The background noise has a substantial influence on quantitation, especially in the case of low-abundance peaks. The contaminant noise derived from other peptides also affects the calculation. Although our instrument operates with high mass resolution (10,000 FWHM) and accuracy (50~100 ppm), it is difficult to distinguish the other peaks with adjacent m/z values. Although it is possible to remove unreliable data when performing analysis manually, our algorithm does not have a function to eliminate them efficiently. Some statistical methods are necessary to deal with this problem.
Reduction of difficulties
The major contributions of this study are as follows: (i) drastic reduction in the manual work required to perform quantitation for large-scale proteome data and (ii) reproducibility of high-quality data that does not depend on the user. In the case of this study, it required 2–6 working days to create the activation profile of the phosphotyrosine-related proteome by manual operation. In contrast, AYUMS could automatically generate the final report within 6 hours using a single machine. It is also possible to perform quantitation in parallel for multiple experimental data. For example, if two machines are available, 3 hours are sufficient for the generation of the final result.
Once the ayums format file is created, the subsequent analysis can be completed within 15 minutes. Thus, it is possible to easily re-evaluate experimental data by changing various options such as the acceptable ratio in Step 4 of Stage 3 and the threshold of the Mascot score.
Future studies
Although a completely automatic quantitation based on the LC-MS/MS data was realized using AYUMS 1.0, further development of this software is required at various points. First, although the input of Stage 1 in AYUMS supports only the Q-tof type raw data, it needs to handle major data formats by NetCDF for more general purposes. Second, it would be very helpful to generate the final result not only in the CSV file format but also in other major formats, such as mzXML [21], for better usability.
The present SILAC method enables us to compare only two or three samples in a single experiment. Relative quantitation of target proteins at multiple points such as in dynamics analysis requires a common standard point to normalize the results of separate experiments. AYUMS will need to support a function of statistical data processing of the normalized results for more precise quantitation.
Although AYUMS is customized for the SILAC method, it can also easily handle the data obtained by other labeling strategies such as isotope-coded affinity tags (ICAT) [22], isobaric tags for relative and absolute quantitation (iTRAQ) [23], and culture-derived isotope tags (CDIT) [24].
This software is open to public access; hence, any researcher can contribute to the development of its application.
AYUMS is a useful software tool for quantitative proteomics by LC-MS/MS technology in combination with the SILAC method. This software completely eliminates the need for manual work that has always been required previously. Besides, it enables us to obtain the final result considerably faster than by manual operation. Our evaluation of the output data by AYUMS indicated that it ranked comparably with the results calculated by an expert in proteomics.
Availability and requirements
• Project home page: http://www.csml.org/ayums/ webcite
• Operating system(s): Java platform independent
• Programming language: Java
• Other requirements: Java 1.4.2 or higher, CyberNeko HTML Parser 0.9.5 or higher
• License: AYUMS software is available from the authors at firstname.lastname@example.com.
• Any restrictions to use by non-academics: Need contract.
Authors' contributions
AS developed the new algorithms for peak recognition, operated the software, and wrote the manuscript. MN developed the new algorithms for peak recognition, helped to implement the algorithms, operate the software and prepare the manuscript. MO initiated this study, provided knowledge about the structure of the input raw data and wrote the manuscript. HK-H performed the experiment and helped to operate the software. KS provided knowledge about biochemistry. SS provided knowledge about proteomics technology. TY provided knowledge about signal transduction. SM supervised the dry study. All the authors read and approved of the final manuscript.
We are grateful to E. Nakajima for critical reading of the manuscript. This work was supported by the Japan Science and Technology Agency.
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We are delighted to announce that we will be returning to the Summer rendition of the Independent Label Market in Old Spitalfields Market this Saturday 11th July! Swing by our stall from 11am-6pm this weekend for exclusive early releases, from the vault rarities, limited edition coloured vinyl and
The wait is over, Fufanu's EP 'Adjust To The Light' is out today and available for you to purchase on 12" Vinyl, CD or Digital Download.
After a stream of London shows this past week, culminating in an enthralling show at Hyde Parks British Summer Time playing alongside Blur, the band celebrate


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Newbury Park High reschedules prom
Newbury Park High School students will get to dance the night away after all.
The prom, scheduled for Saturday at the Skirball Cultural Center in Los Angeles, was canceled after county public health officials ordered the school closed on Monday because a student tested positive for the swine flu.
Students were dismissed early Monday, and classes are tentatively set to resume May 12.
The prom has been rescheduled to June 5 and will take place at the same venue, Dean of Activities Larry Berlin said today.
Prom ticket sales have been extended to May 22. Students who cannot attend the prom on its new date will receive ticket refunds, Berlin said.
Read more about the closing of the Newbury Park High School yesterday.
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WEST LAFAYETTE, Ind. - The National Nuclear Security Administration has awarded a $17 million cooperative agreement for a research center at Purdue University's Discovery Park to develop advanced simulations for commercial and defense applications, Purdue officials announced Friday (March 7).
The center will focus on the behavior and reliability of miniature switches and is one of five new Centers of Excellence chosen by the NNSA.
About 35 researchers at Purdue, including faculty members, software professionals and students, will be involved in the new Center for Prediction of Reliability, Integrity and Survivability of Microsystems, or PRISM. The University of Illinois, Urbana-Champaign, and the University of New Mexico will collaborate in the center.
"The center takes advantage of Purdue's interdisciplinary strengths and considerable expertise in computational modeling and nanotechnology," Purdue President France A. Crdova said.
The center will advance the emerging field of "predictive science," or applying computational simulations to predict the behavior of complex systems, said Jayathi Y. Murthy, director of the new center and a professor in Purdue's School of Mechanical Engineering.
The new centers will develop advanced science and engineering models and software for simulations needed to predict the reliability and durability of "micro-electromechanical systems," or MEMS. Researchers also will develop methods associated with the emerging disciplines of verification and validation and uncertainty quantification.
"The goal of these emerging disciplines is to enable scientists to make precise statements about the degree of confidence they have in their simulation-based predictions," Murthy said.
PRISM will be based at the Birck Nanotechnology Center and also is affiliated with the Energy Center, both in Purdue's Discovery Park.
The center is funded with $17 million over five years f
|Contact: Phillip Fiorini
Purdue University


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Set of magnetic Shakespearean insults.Size 190mm x 286mm
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