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8/6/12: Dr. Hongjun Song in the News
Stem Cells "Eavesdrop" to find out when to act
Working with mice, Johns Hopkins researchers say they have figured out how stem cells found in a part of the brain responsible for learning, memory and mood regulation decide to remain dormant or create new brain cells.
8/6/12: Dr. Min Li in the News
Drug Shows Promise for Long QT Syndrome
Johns Hopkins researchers have discovered a new drug that may be useful in treating a heart rhythm condition called long QT syndrome.
7/25/12: Dr. Paul Worley in the News
Discovered Scaffold Supports Turning Pain Off
Johns Hopkins scientists have discovered a "scaffolding" protein that holds together multiple elements in a complex system responsible for regulating pain, mental illnesses and other complex neurological problems.
6/15/12: Dr. Hal Dietz in the News
Hal Dietz Awarded For Excellence in Translational Medicine
The A. Alfred Taubman Medical Research Institute at the University of Michigan has awarded Harry Dietz, M.D., the inaugural 2012 Taubman Prize for Excellence in Translational Medical Research.
5/2/12: Dr. Alfredo Quinones-Hinojosain the News
Breakthrough in slowing the spread of deadly brain cancer
The diagnosis of a gioblastoma, one of the most common and deadliest of brain tumors, can be devastating. While the cancer alone is harmful, its most lethal aspect is the speed at which it travels through the brain, infecting healthy tissue.
4/13/12: Dr. Carol Greider in the News
Greider will be part of a committee of 12 engineers and scientists appointed by the president to evaluate nominees for award.
Today President Obama announced his intention to appoint Dr. Carol Greider the Daniel Nathans Professor and Director of Molecular Biology and Genetics in the Johns Hopkins Institute for Basic Biomedical Sciences, to the Committee on the National Medal of Science..
2/20/12: Dr. Robert D. Siliciano in the News
New Studies Show Which Anti-HIV Drug Combinations Work Better Than Others -- And Why And How They Do It
The study results should help researchers and clinicians develop simpler treatments, using either existing or new drugs, for people who are just starting therapy or people who have already tried and developed resistance to another combination," says senior study investigator and infectious disease specialist Dr. Robert F. Siliciano
12/27/11: Dr. Zaver Bhujwalla in the News
Cellular-Imaging Center Gets Over $8 Million to Speed Search for Earlier Diagnostic Tests and Treatments for Cancer
A team of cancer imaging expertswith the principal investigator, Dr. Zaver Bhujwalla at Johns Hopkins has embarked on a five-year research initiative to speed development of early diagnostic tests and new treatments for breast, prostate and other common cancers.
11/14/11: Dr. Antony Rosen in the News
Sibley Supports Rheumatoid Research
Sibley Memorial Hospital has awarded Dr. Antony Rosen and his colleagues nearly $1.2 million to fund a research project entitled "Precision Measurement in Rheumatoid Arthritis"
11/9/11: Dr. Charles Rudin in the News
Combination Epigenetic Therapy Clinical Trial Results
A new type of therapy aimed at reversing the gene-silencing that promotes cancer-cell growth has shown promising results in a small clinical trial conducted by researchers at the Johns Hopkins Kimmel Cancer Center.
Rudin led the team of physicians and cancer biologists who conducted the study. The trial was based in part on the results of a study reported in the New England Journal of Medicine in 2008 by a group of Johns Hopkins researchers, including cancer epigenetics experts Dr. Stephen Baylin the Virginia and D.K. Ludwig Professor for Cancer Research and deputy director of the Kimmel Cancer Center, and Dr. James Herman professor of oncology.
11/8/11: Dr. Gregg Semenza in the News
Johns Hopkins Researchers Discover How Breast Cancer Spreads to Lung
The spread of breast cancer is responsible for more than 90 percent of breast cancer deaths. Now, the process by which it spreads -- or metastasizes -- has been unraveled by researchers at Johns Hopkins.
11/4/11: Dr. Robert A. Casero, Jr. in the News
Johns Hopkins scientists have found that a strain of the common gut pathogen Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase (SMO) in the intestine. The effect is to expose the gut to hydrogen peroxide – the caustic, germ-fighting substance found in many medicine cabinets -- and cause DNA damage, contributing to the formation of colon tumors, say the scientists.
10/31/11: Dr. Sara Sukumar in the News
Johns Hopkins Researcher Wins Prize For Breast Cancer Biomarker Studies
A Johns Hopkins breast cancer researcher is the recipient of a $50,000 award designed to encourage rapid translation of her basic research on biomarkers into a commercially available test that could predict the best treatment options for some women with breast cancer.
10/26/11: Dr. Sara Sukumar in the News
Through-the-Nipple Breast Cancer Therapy Shows Promise in Early Tests
Delivering anticancer drugs into breast ducts via the nipple is highly effective in animal models of early breast cancer, and has no major side effects in human patients, according to a report by Johns Hopkins Kimmel Cancer Center researchers in Science Translational Medicine on Oct. 26. The results of the study are expected to lead to more advanced clinical trials of so-called intraductal treatment for early breast cancer.
6/2/11: Dr. Virginia Willour in the News
Findings could lead to new avenues of treatment research
A study of thousands of people with bipolar disorder suggests that genetic risk factors may influence the decision to attempt suicide.
6/2/2011: Dr. Gregg Semenza in the News
UNDERSTANDING CANCER ENERGETICS Johns Hopkins researchers solve mystery of Warburg effect
It's long been known that cancer cells eat a lot of sugar to stay alive. In fact, where normal, noncancerous cells generate energy from using some sugar and a lot of oxygen, cancerous cells use virtually no oxygen and a lot of sugar. Many genes have been implicated in this process and now, reporting in the May 27 issue of Cell, researchers at the Johns Hopkins University School of Medicine have discovered that this so-called Warburg effect is controlled.
5/23/2011: Dr. Garry Cutting in the News
Johns Hopkins researchers identify genes linked to worsening of cystic fibrosis
Johns Hopkins Institute for Genetic Medicine researchers working as part of the North American Cystic Fibrosis Consortium have discovered two regions of the genome that affect the severity of cystic fibrosis, a genetic condition that causes scarring throughout the body, affecting most notably the pancreas and lungs. Reporting online this week in Nature Genetics, the team describes the first-ever study to identify genetic variations that are associated with more severe cases of CF.
5/23/2011: Dr. Valina Dawson in the News
WHAT DOESN'T KILL THE BRAIN MAKES IT STRONGERJohns Hopkins team discovers brain defense in mice and a possible new strategy for treating neurologic disorders
Johns Hopkins scientists say that a newly discovered "survival protein" protects the brain against the effects of stroke in rodent brain tissue by interfering with a particular kind of cell death that's also implicated in complications from diabetes and heart attack.
5/16/2011: Dr. Annabelle Rodriguez in the News
Altered gene involved in both faulty cholesterol regulation and pregnancy hormone production
A variation in a gene involved in regulating cholesterol in the bloodstream also appears to affect progesterone production in women, making it a likely culprit in a substantial number of cases of their infertility, a new study from Johns Hopkins researchers suggests.
5/11/2011: Dr. Hal Dietz in the News
Harry C. "Hal" Dietz, III, M.D., the Victor A. McKusick Professor of Genetics and Medicine at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins and an investigator of the Howard Hughes Medical Institute is one of 72 new members of the National Academy of Sciences, an honorary society that advises the government on scientific matters.
5/2/2011: Dr. David Kass in the News
Scientists at Johns Hopkins have shown in laboratory experiments in mice that blocking the action of a signaling protein deep inside the heart's muscle cells blunts the most serious ill effects of high blood pressure on the heart. These include heart muscle enlargement, scar tissue formation and loss of blood vessel growth.
4/21/2011: Dr. Peter Espenshade in the News
A discovery by Johns Hopkins scientists about how a single-celled fungus survives in low-oxygen settings may someday help humans whose immune systems are compromised by organ transplants or AIDS.
4/14/2011: Dr. Hongjun Song in the News
Using human kidney cells and brain tissue from adult mice, Johns Hopkins scientists have uncovered the sequence of steps that makes normally stable DNA undergo the crucial chemical changes implicated in cancers, psychiatric disorders and neurodegenerative diseases. The process may also be involved in learning and memory, the researchers say.
4/6/2011: Dr. Akira Sawa in the News
Johns Hopkins researchers report the discovery of a molecular switch that regulates the behavior of a protein that, when altered, is already known to increase human susceptibility to schizophrenia and mood disorders.The findings, published online in the journal Nature, expand the possibility of creating biomarkers that can better diagnose those with mental illnesses and track their treatment.
4/6/2011: Dr. Richard Huganir in the News
With the help of two sets of brothers with autism, Johns Hopkins scientists have identified a gene associated with autism that appears to be linked very specifically to the severity of social interaction deficits. The gene, GRIP1 (glutamate receptor interacting protein 1), is a blueprint for a traffic-directing protein at synapses — those specialized contact points between brain cells across which chemical signals flow.
3/24/2011: Dr. Mary Armanios in the News
--New Role for Short Telomeres
New evidence has emerged from studies in mice that short telomeres or "caps" at the ends of chromosomes may predispose people to age-related diabetes, according to Johns Hopkins scientists.
3/17/2011: Dr. Russ Margolis in the News
Scientists use new technique to reprogram cells with risk gene for major mental illness
Using skin cells from adult siblings with schizophrenia and a genetic mutation linked to major mental illnesses, Johns Hopkins researchers have created induced pluripotent stem cells (iPS cells) using a new and improved "clean" technique.
4/16/10: Dr. Andrew Feinberg in the News
Andrew Feinberg, MD, MPH is one of two genetics researchers from the Johns Hopkins University School of Medicine that have been awarded prestigious honorary Doctor of Medicine degrees by European scientific institutions.
4/6/10: Dr. Gregg Semenza in the News
- Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Pediatrics, director of the vascular program at the Johns Hopkins Institute for Cell Engineering and a member of the McKusick-Nathans Institute of Genetic Medicine, is one of seven recipients of the 2010 Canada Gairdner Awards. Canada's only international science prizes, they are among the world's most prestigious medical research awards.
3/30/10: Dr. David Yue in the News
Congenital stationary night blindness, an inherited condition that affects one's ability to see in the dark, is caused by a mutation in a calcium channel protein that shuttles calcium into and out of cells. Now, researchers at the Johns Hopkins University School of Medicine have teased apart the molecular mechanism behind this mutation, uncovering a more general principle of how cells control calcium levels. The discovery, published in the Feb. 18 issue of Nature, could have implications for several other conditions, including neurodegenerative diseases such as schizophrenia and Alzheimer's, Parkinson's and Huntington's diseases.
10/5/09: Dr. Carol Greider in the News
Carol Greider, Ph.D., 48, one of the worlds pioneering researchers on the structure of chromosome ends known as telomeres, today was awarded the 2009 Nobel Prize in Physiology or Medicine by the Royal Swedish Academy of Sciences. The Academy recognized her for her 1984 discovery of telomerase an enzyme that maintains the length and integrity of chromosome ends and is critical for the health and survival of all living cells and organism.
9/30/09: Dr. Stephen Baylin in the News
JOHNS HOPKINS AND USC WIN $10.4 MILLION TO STUDY CANCER EPIGENOME The National Cancer Institute (NCI) has awarded $10.4 million to Johns Hopkins and The University of Southern Califonia (USC) to decipher epigenetic marks in the cancer genome. The joint five-year grant is expected to help scientists develop drugs and tests that target epigenetic changes in cancer cells. Scientists at Johns Hopkins' and USC's Epigenome Center will focus on all major cancers, including breast, colon, and lung cancer. The data will be collected as part of The Cancer Genome Atlas (TCGA), a program funded by the NCI and National Human Genome Research Institute (NHGRI) to develop a molecular map of alterations in cancer.
"We've learned that in addition to the DNA damage that happens at the genetic level, cancers can arise because of abnormal changes that occur in the way DNA is packaged," says Stephen Baylin, M.D., deputy director of the Johns Hopkins Kimmel Cancer Center and co-principal investigator with Peter W. Laird, Ph.D. of USC.
9/28/09: Dr. Andrew Feinberg in the News
Johns Hopkins' Center for the Epigenetics of Common Human Disease has been chosen as one of four recipients of a $45 million National Institutes of Health (NIH) grant for Centers of Excellence to advance genomics research. The Hopkins Center will receive $16.8 million over five years.
"We're grateful for such generous support to continue our work in understanding how epigenetic control affects disease," says the center's director, Andrew Feinberg, M.D., M.P.H.
9/21/09: Dr. Landon King in the News
HEALING BADLY DAMAGED LUNGS: DISTINCT SET OF WHITE BLOOD CELLS FOUND TO SET THE PACE OF WOUND REPAIR After more than 50 experiments in mice, medical scientists at Johns Hopkins have mapped out the basic steps taken by a particular set of white blood cells in setting the pace of recovery after serious lung injury.
The white blood cells are called regulatory T cells, or Tregs for short, and their best known function is to keep the body's immune system from attacking its own healthy tissues.
"Our study results are the critical first leads in finding treatments for a clinical condition that until now has had none, despite its high mortality," says study senior investigator and pulmonologist Landon King, M.D. "When a patient develops acute lung injury, we want the critical care medicine team to be able to do more than just stabilize the patient on a ventilator," adds King, director of pulmonary and critical care medicine at the Johns Hopkins University School of Medicine.
9/17/09: Dr. Shanthini Sockanathan in the News
Researchers at the Johns Hopkins School of Medicine have discovered how one antioxidant protein controls the activity of another protein, critical for the development of spinal cord neurons. The research, publishing this week in Cell, describes a never-before known mechanism of protein control.
"This is the first time we've seen this type of chemical reaction control neuronal differentiation," says Shanthini Sockanathan, Ph.D., an associate professor at the Johns Hopkins Solomon H. Snyder Department of Neuroscience. "And it's probably not specific for motor neurons that we study, but also for development of a wide variety of neurons."
9/15/09: Dr. Charles Rudin in the News
Guide on Lung Cancer in "Never-Smokers": Different Disease, Different Treatments
A committee of scientists led by Johns Hopkins investigators has published a new guide to the biology, diagnosis and treatment of lung cancer in never-smokers, fortifying measures for what physicians have long known is a very different disease than in smokers.
"It is becoming increasingly clear that the genetic, cellular, and molecular nature of lung cancer in many never-smokers is different from that of smoking-related lung cancers, and there is good evidence now that the best treatment and prevention strategies for never-smokers may be different as well," says Charles M. Rudin, M.D., Ph.D., associate director for clinical research at the Johns Hopkins Kimmel Cancer Center. Lung cancer in never-smokers is the sixth-leading cause of cancer-related deaths in the U.S.
9/3/09: Dr. Charles Rudin in the News
ANTICANCER DRUG YIELDS POSITIVE RESPONSE IN PEOPLE WITH ADVANCED OR RECURRING SKIN AND BRAIN CANCER The Hedgehog signaling pathway is involved in a preliminary study and case report describing positive responses to an experimental anticancer drug in a majority of people with advanced or metastatic basal cell skin cancers. One patient with the most common type of pediatric brain cancer, medulloblastoma, also showed tumor shrinkage.
Initial results of the drug trial, conducted at Johns Hopkins (Baltimore), the Karmanos Cancer Center (Detroit) and the Translational Genomics Research Institute (Scottsdale, Ariz.) are published online Sept. 3 in the New England Journal of Medicine. The publication also details side effects of the drug, including muscle cramping, hair loss, fatigue and low blood sodium.
"We know that both of these cancer types have mutations in Hedgehog pathway genes, and our results with Hedgehog inhibitors could be the starting point for developing a new type of therapy for these intractable cancers," says Charles Rudin, M.D., Ph.D., associate director for Clinical Research at the Johns Hopkins Kimmel Cancer Center.
8/6/09: Dr. David Berman in the News
Johns Hopkins scientists have tracked down a powerful set of cells in bladder tumors that seem to be primarily responsible for the cancer's growth and spread using a technique that takes advantage of similarities between tumor and organ growth. The findings, reported in the July Stem Cells, could help scientists develop new ways of finding and attacking similar cells in other types of cancer.
These same properties are the ones that make cancer particularly dangerous, says David Berman, M.D., Ph.D., associate professor of pathology, oncology, and urology at the Johns Hopkins University School of Medicine. If researchers had a way to identify and specifically target cancer cells with these properties, they could wipe out the population that sustains tumors and makes them grow.
7/10/09: Dr. Chris Zink in the News
A Johns Hopkins veterinarian whose vocation is HIV research and avocation is the care of dog "athletes" has been named the 2009 Outstanding Woman Veterinarian of the Year by the Association for Women Veterinarians Foundation.
M. Christine Zink, D.V.M., Ph.D., professor and director of the Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, and a Hopkins faculty member for 21 years will be recognized for wide-ranging professional achievements with an award presented Tuesday, July 14, at the American Veterinary Medical Association convention in Seattle
6/29/09: Dr. William Bishai in the News
Tuberculosis (TB) experts at Johns Hopkins have evidence from a four-year series of experiments in mice that anti-inflammatory drugs could eventually prove effective in treating the highly contagious lung disease, adding to current antibiotic therapies.
The Johns Hopkins scientists are planning further experiments in animals infected with TB to find out if any of the already-approved anti-inflammatory drugs -- phosphodiesterase (PDE5A) inhibitors, such as sildenafil citrate (Viagra) and adenylate cyclase (AC) inhibitors – would work.
The new study results, to be reported in the July 2 issue of Nature, not only offer promise of a complementary or alternative therapy to antibiotics, but also open the door to vaccines designed to block the TB bacterium's inflammatory chemical pathways, the researchers say. The disease, caused by Mycobacterium tuberculosis, each year infects nearly 9 million people worldwide, and kills 1.7 million.
6/18/09: Dr. Linzhao Cheng in the News
Researchers at the Johns Hopkins School of Medicine have successfully edited the genome of human- induced pluripotent stem cells, making possible the future development of patient-specific stem cell therapies. Reporting this week in Cell Stem Cell, the team altered a gene responsible for causing the rare blood disease paroxysmal nocturnal hemoglobinuria, or PNH, establishing for the first time a useful system to learn more about the disease.
"To date, only about six genes have been successfully targeted or edited in human stem cells out of countless people and attempts—that's just not efficient enough if we want to move disease research and therapy forward," says Linzhao Cheng, Ph.D., an associate professor of gynecology and obstetrics and member of the Johns Hopkins Institute of Cell Engineering. "We've been able to improve gene targeting and editing in human embryonic stem cells more than 200 fold."
6/10/09: Dr. Richard Huganir in the News
JOHNS HOPKINS NEUROSCIENTISTS WATCH MEMORIES FORM IN REAL TIME Our ability to form long-term memories depends on cells in the brain making strong connections with each other. Yet while it's not well understood how those connections are made, lost or changed, the process is known to involve the movement of the AMPA receptor protein to and from those neuronal connections. Reporting this week in Nature Neuroscience, researchers at the Johns Hopkins School of Medicine have discovered by watching live neurons that the AMPA receptor goes where it needs to be with the help of the 4.1N protein, without which long term memories are not formed.
"This has been a long-standing challenge in the field, trying to see a process that involves a handful of molecules and occurs so quickly, on the order of one-tenth of a second," says Richard Huganir, Ph.D., professor and director of the Solomon H. Snyder Department of Neuroscience at Johns Hopkins. "We just haven't had the right tools." Huganir's research team spent a year building a new microscope to do the experiments.
6/4/09: Dr. Solomon Snyder in the News
June 4, 2009- Johns Hopkins brain scientists have figured out why a faulty protein accumulates in cells everywhere in the bodies of people with Huntington's disease (HD), but only kills cells in the part of the brain that controls movement, causing negligible damage to tissues elsewhere. The answer, reported this week in Science, lies in one tiny protein called "Rhes" that's found only in the part of the brain that controls movement. The findings, according to the Hopkins scientists, explain the unique pattern of brain damage in HD and its symptoms, as well as offer a strategy for new therapy.
HD itself is caused by a genetic defect that produces a mutant version of the protein "huntingtin" that gathers in all cells of the body, but only seems to affect the brain. Passed from parent to child through an alteration of a normal gene, HD over time causes irreversible uncontrolled movement, loss of intellectual function, emotional disturbances and death.
"It's always been a mystery why, if the protein made by the HD gene is seen in all cells of the body, only the brain, and only a particular part of the brain, the corpus striatum, deteriorates," says Solomon H. Snyder, M.D., professor of neuroscience at Johns Hopkins. "By finding the basic culprit, the potential is there to develop drugs that target it and either prevent symptoms or slow them down."
4/8/09: Dr. Jeffrey D. Rothstein in the News
A just-out study suggests that what keeps chronic nervous system diseases such as Alzheimer's, Huntington's and ALS going — until they overcome the internal protective mechanisms a body can throw at them — may largely come down to poor conversational skills.
In the current issue of the journal Neuron, a team of Johns Hopkins scientists reports uncovering a much-sought molecular path that nerve cells (neurons) use to communicate with their neighboring cells, the astrocytes.
The team also shows how failure of this system could leave the brain and spinal cord vulnerable in disease.
Astrocytes are the most plentiful central nervous system cells. And while scientists have known for some time that they're critical for neurons' normal activity and even for their survival, precisely how the two cell types communicate hasn't been clear.
"This new work shows that neurons dynamically direct astroglia," says team leader Jeffrey Rothstein, M.D., Ph.D., "but more important to medicine, it defines how neurological disease may spread throughout the nervous system."
2/15/09: Dr. Chi Dang in the News
Cancer cells need a lot of nutrients to multiply and survive. While much is understood about how cancer cells use blood sugar to make energy, not much is known about how they get other nutrients. Now, researchers at the Johns Hopkins University School of Medicine have discovered how the Myc cancer-promoting gene uses microRNAs to control the use of glutamine, a major energy source. The results, which shed light on a new angle of cancer that might help scientists figure out a way to stop the disease, appear Feb. 15 online at Nature.
"While we were looking for how Myc promotes cancer growth, it was unexpected to find that Myc can increase use of glutamine by cancer cells," says Chi V. Dang, M.D., Ph.D., the Johns Hopkins Family Professor of Oncology at Johns Hopkins. "This surprising discovery only came about after scientists from several disciplines came together across Hopkins to collaborate — it was a real team effort."
2/2/09: Dr. Gordon Tomaselli in the News
Physician-scientist Gordon Tomaselli, M.D., an expert on sudden cardiac death and heart rhythm disturbances, has been named the new director of the Johns Hopkins University School of Medicine's Division of Cardiology and co-director of the School's Heart and Vascular Institute.
Tomaselli, who has been at Johns Hopkins since 1986, succeeds Eduardo Marbán, M.D., Ph.D., who led the division since 2002 and will remain active as adjunct faculty. He also succeeds Marbán as the Michel Mirowski, M.D., Professor of Cardiology.
Tomaselli, 53, a cardiac electrophysiologist, has focused most of his research efforts on arrhythmias, and especially on new therapies aimed at warding off the potentially fatal heart condition. More than 300,000 Americans suddenly die each year when the heart suddenly stops pumping blood, triggered by an electrical disturbance in the heart.
In addition to his new roles, Tomaselli will continue as co-director of the Donald W. Reynolds Cardiovascular Clinical Research Center at Hopkins, funded in 2003 to carry out research into the causes of sudden cardiac death.
1/18/09: Dr. Andrew Feinberg in the News
Study vastly expands prospects for understanding disease and new treatments against colon cancer
Scientists who study how human chemistry can permanently turn off genes have typically focused on small islands of DNA believed to contain most of the chemical alterations involved in those switches. But after an epic tour of so-called DNA methylation sites across the human genome in normal and cancer cells, Johns Hopkins scientists have found that the vast majority of the sites aren't grouped in those islands at all, but on nearby regions that they've named "shores."
"Our study suggests that the real jackpot for methylation isn't where we have all been looking, but in these shores located just nearby," says Andrew Feinberg, M.D., M.P.H., professor of medicine at the Johns Hopkins University School of Medicine.
1/8/09: Dr. Hongjun Song in the News
New cells are born every day in the brain's hippocampus, but what controls this birth has remained a mystery. Reporting in the January 1 issue of Science, neuroscientists at the Johns Hopkins University School of Medicine have discovered that the birth of new cells, which depends on brain activity, also depends on a protein that is involved in changing epigenetic marks in the cell's genetic material.
"How is it that when you see someone you met ten years ago, you still recognize them? How do these transient events become long lasting in the brain, and what potential role does the birth of new neurons play in making these memories?" says Hongjun Song, Ph.D., an associate professor of neurology and member of the Johns Hopkins Institute of Cell Engineering's NeuroICE. "We really want to understand how daily life experiences trigger the birth and growth of new neurons, and make long-lasting changes in the brain."
1/5/09: Dr. Gregg Semenza in the News
Digitalis-based drugs like digoxin have been used for centuries to treat patients with irregular heart rhythms and heart failure and are still in use today. In the Dec. 16 issue of the Proceedings of the National Academy of Sciences, researchers at the Johns Hopkins University School of Medicine now report that this same class of drugs may hold new promise as a treatment for cancer. This finding emerged through a search for existing drugs that might slow or stop cancer progression.
"This is really exciting, to find that a drug already deemed safe by the FDA also can inhibit a protein crucial for cancer cell survival," says Gregg L. Semenza, M.D., Ph.D., director of the vascular program at the Johns Hopkins Institute for Cell Engineering and a member of the McKusick-Nathans Institute of Genetic Medicine.
1/5/09: Dr. David Kass in the News
VIAGRA'S OTHER TALENTS: TO HELP A 'SIGNALING' PROTEIN SHIELD THE HEART FROM HIGH BLOOD PRESSURE DAMAGE Johns Hopkins and other researchers report what is believed to be the first direct evidence in lab animals that the erectile dysfunction drug sildenafil amplifies the effects of a heart-protective protein.
The team's findings, to be published in the Journal of Clinical Investigation online Jan. 5, helps explain why sildenafil, more widely known as Viagra, has already been shown to improve heart function and may one day have value in either treating or preventing heart damage due to chronic high blood pressure.
7/31/08: Dr. David Yue in the News
LIKE EAVESDROPPING AT A PARTY. Cells rely on calcium as a universal means of communication. For example, a sudden rush of calcium can trigger nerve cells to convey thoughts in the brain or cause a heart cell to beat. A longstanding mystery has been how cells and molecules manage to appropriately sense and respond to the variety of calcium fluctuations within cells. Reporting in the June 27 issue of Cell, a team of biomedical engineers at the Johns Hopkins School of Medicine has discovered how the calcium sensor protein calmodulin can gauge both the local flow of calcium, in through the closest channel, as well as the global calcium flow entering the many channels across the entire cell."It's like being at a cocktail party where the easiest person to listen to is the one closest to you, but we all have the ability to keep an ear out for other interesting conversations going on throughout the room," says David Yue, M.D., Ph.D., a professor of biomedical engineering at Hopkins.
7/14/08: Dr. Stephen Baylin in the News
Releases&action=showthisitem "SMOTHERED" GENES COMBINE WITH MUTATIONS TO YIELD POOR OUTCOME IN CANCER PATIENTS. Johns Hopkins Kimmel Cancer Center researchers have identified a set of genes in breast and colon cancers with a deadly combination of traditional mutations and "smothered" gene activity that may result in poor outcomes for patients. "Until studies like ours, it was easy to think that if we didn't find gene mutations in certain biochemical pathways linked to breast or colon cancer, then those pathways were normal in such patients," says Stephen Baylin, M.D., the Virginia and D.K. Ludwig Professor for Cancer Research and deputy director of the Kimmel Cancer Center. "Now we know that, in some patients, the pathways involved with newly discovered mutated genes are often more frequently disrupted by epigenetic mechanisms rather than genetic ones." A report on this work appeared May 27 in PLoS Medicine.
6/25/08: Dr. Harry Dietz in the News
Drug Treatment for Marfan Syndrome Looks Promising, Johns Hopkins Researchers Say. A small study in 18 pattients assessing the effectiveness of the drug losartan for treating Marfan syndrome in children has yielded encouraging results. Reporting in the June 26 issue of The New England Journal of Medicine, Johns Hopkins researchers showed that losartan-a compound used for years to treat high blood pressure-slowed the enlargement of the aorta, the most life-threatening defect associated with Marfan syndrome "This experience increases my belief that losartan holds great promise for treating Marfan syndrome," says Harry Dietz, M.D., a professor in the McKusick-Nathans Institute of Genetic Medicine and director of the William S. Smilow Center for Marfan Syndrome Research at Hopkins. "This would be the first therapy generated by basic research that revealed the molecular mechanism of this genetic disease."
6/24/08: Dr. Andrew Feinberg in the News
MENDEL DIDN'T HAVE THE WHOLE PICTURE: OUR GENOME CHANGES OVER LIFETIME, JOHNS HOPKINS EXPERTS SAY. Contrary to conventional wisdom, it appears that while the overall health of our genomes is indeed inherited from our parents, chemical marks on our genomes' DNA sequences actually change as we age, driving increased risk of disease susceptibility for us and similarly for our close family members. Summarizing results of an international collaborative research project, Andrew Feinberg, M.D., M.P.H., concluded that "we're beginning to see that changes wrought by these epigenetic marks may help explain why susceptibility to many diseases such as diabetes and cancer increases with age."
6/15/08: Dr. Robert Siliciano in the News
NEW INDEX EXPLAINS WHY SOME DRUGS WORK BETTER THAN OTHERS AGAINST HIV. A team of AIDS experts at Johns Hopkins has found a simple mathematical equation that accurately explains how well each of 25 anti-HIV drugs in five commonly used drug groups suppresses the virus and keeps the disease in check. The team's findings are set to appear online June 15 in the journal Medicine.
"It has become clear that after more than a decade of using drug combinations to fight HIV, we need a better tool than the IC50 to let us compare drugs in a way that reflects their ability to suppress the virus," says senior study investigator and infectious disease specialist Robert Siliciano, M.D., Ph.D.
5/29/08: Dr. Linzhao Cheng in the News
JOHNS HOPKINS RESEARCHERS DEVELOP HUMAN STEM CELL LINE CONTAINING SICKLE CELL ANEMIA MUTATION. Researchers at Johns Hopkins have established a human cell-based system for studying sickle cell anemia by reprogramming somatic cells to an embryonic stem cell like state. Publishing online in Cellson May 29, the team describes a faster and more efficient method of reprogramming cells that might speed the development of stem cell therapies."We hope our new cell lines can open the doors for researchers who study diseases like sickle cell anemia that are limited by the lack of good experimental models," says Linzhao Cheng, Ph.D., an associate professor of gynecology and obstetrics, medicine and oncology and a member of the Johns Hopkins Institute for Cell Engineering
4/30/08: Dr. Gregg Semenza in the News
JOHNS HOPKINS PROFESSORS ELECTED TO NATIONAL ACADEMY OF SCIENCES. Gregg L. Semenza, M.D., Ph.D., a professor of pediatrics at The Johns Hopkins School of Medicine and Jane I. Guyer, Ph.D., a professor of anthropology at The Johns Hopkins University were elected as members of the National Academy of Sciences (NAS) for their excellence in original scientific research. Membership in the NAS is one of the highest honors given to a scientist or engineer in the United States. Semenza and Guyer will be inducted into the Academy next April during its 146th annual meeting in Washington, D.C..
4/9/08: Dr. Linzhao Cheng in the News
HUMAN EMBRYONIC STEM CELL RESEARCH REVEALS EARLIEST STEP IN HUMAN DEVELOPMENT. Researchers at Johns Hopkins have uncovered the molecular underpinnings of one of the earliest steps in human development using human embryonic stem cells. Their identification of a critical signal mediated by the protein BMP-4 that drives the differentiation of stem cells into what will become the placenta, will be published in the April issue of Cell Stem Cell. "The finding was serendipitous and at the same time a very important addition to our understanding of early human development," says Linzhao Cheng, Ph.D., an associate professor of gynecology and obstetrics and co-director of the stem cell program of the Johns Hopkins Institute for Cell Engineering.
3/11/08: Dr. Maura Gillison in the News
RESEARCHERS ID BEHAVIORAL RISK FACTORS FOR HEAD AND NECK CANCERS. Researchers at the Johns Hopkins Kimmel Cancer Center have teased out two distinct sets of risk factors for head and neck cancers, suggesting that there are two completely different kinds of the disease. "Our results indicate that HPV-positive and HPV-negative head and neck cancers have different risk-factor profiles and should be considered two distinct diseases," says Maura L. Gillison, M.D., Ph.D., an associate professor of oncology and epidemiology at Hopkins. "They just happen to occur in the same place."
1/29/08: Dr. Garry Cutting in the News
SECONDHAND SMOKE EXPOSURE WORSENS CYSTIC FIBROSIS. Researchers at Johns Hopkins have discovered the first genetic evidence that secondhand smoke can worsen lung disease. The report in this week's Journal of the American Medical Association describes one gene variation that can weaken lung function as well as shorten the lifespan of those affected by cystic fibrosis and also are exposed to secondhand smoke. "We're really surprised that such a small genetic change can double the negative effects of secondhand smoke on lung function in these patients," says Garry Cutting, M.D., a professor of pediatrics and medicine.
1/22/08: Dr. Solomon Snyder in the News
PROTEIN CLASS DISPLAYS STRONG ANTICANCER ACTION. "A major hang-up in cancer chemotherapy is the toxicity caused by DNA disruption of cell division throughout the body. Our research suggests that drugs like cisplatin and novobiocin kill cells as much from this newly discovered mechanism as any other mechanism of cell death," says Solomon H. Snyder, M.D., a professor of neuroscience at Hopkins. "Targeting this new mechanism in drug design might make for therapies with fewer side effects." The results appear in last week's Early Edition of the Proceedings of the National Academy of Sciences.
1/17/08: Dr. Gregory Germino in the News
KIDNEY CYSTS: NOT ALL CREATED EQUAL Researchers at Johns Hopkins have discovered a window in kidney growth that affects the onset of polycystic kidney disease and can mean, in mice, the difference between developing severe cystic disease early in adolescence or late in adulthood. In the December issue of Nature Medicine, the team reports that genetic mutations acquired before this window result in immediate disease onset whereas those acquired after don't give rise to disease until late adulthood.
1/4/08: Dr. Victor Velculescu in the News
WORTH A THOUSAND WORDS: HOPKINS RESEARCHERS PAINT PICTURE OF CANCER-PROMOTING CULPRIT. They say that a picture can be worth a thousand words. This especially is true for describing the structures of molecules that function to promote cancer. Researchers at Johns Hopkins have built a three-dimensional picture of an enzyme often mutated in many types of cancers. The results, published Dec. 14 in Science , suggest how the most common mutations in this enzyme might lead to cancer progression.
1/3/08: Dr. Roger Reeves in the News
GENE DOSE AFFECTS TUMOR GROWTH. Researchers at Johns Hopkins and Ohio State University have found that the number of copies of a particular gene can affect the severity of colon cancer in a mouse model. Publishing in the Jan. 3 issue of Nature, the research team describes how trisomy 21, or Down syndrome in humans, can repress tumor growth.
12/10/07: Dr. Andrew Feinberg in the News
KEEPING AT-RISK CELLS FROM DEVELOPING CANCER. Researchers at Johns Hopkins have discovered that cancers arising from epigenetic changes - in this case the inappropriate activation of a normally silent gene - develop by becoming addicted to certain growth factors. Reporting online in next week's Early Edition of the Proceedings of the National Academies of Sciences, the team shows that blocking this "addiction" can greatly prevent cancer growth. "If this is translatable to people, it could be really exciting," says Andrew Feinberg, M.D., professor of medicine, oncology and molecular biology and genetics and director of the Epigenetics Center at Hopkins. "It means we might be able to do something about at-risk cells before cancer develops, and treat these cells biochemically and specifically, rather than using current drugs that are nonspecific and kill everything in their path."
11/19/07: Dr. Jeff Rothstein in the News
$1.5 MILLION CINQUE FOUNDATION GRANT GOES TO ALS DRUG RESEARCH AT JOHNS HOPKINS PACKARD CENTER. The Robert Packard Center for ALS Research at Johns Hopkins announced today that it has received a three-year, $1.5 million grant from the Cinque Foundation. The money will support the screening of thousands of drugs already approved by the U.S. Food and Drug Administration and on the market for their potential value in treating people with amyotrophic lateral sclerosis, or ALS.
10/31/07: Dr. Roger Reeves in the News
HOPKINS RESEARCHER AWARDED GRANT TO PURSUE POTENTIAL DOWN SYNDROME TREATMENT. The Down Syndrome Research and Treatment Foundation has awarded a $250,000 grant to Roger H. Reeves, Ph.D., a professor of physiology and member of the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins. Reeves and his research team will extend their current studies on a potential drug to see if its positive effects can improve brain development in mouse models of Down syndrome
10/18/07: Genome Update Defines Landscape of Breast and Colon Cancers.
One year after completing the first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center scientists, Bert Vogelstein, Ken Kinzler, Victor Velculescu, have studied the vast majority of protein-coding genes which now suggest a landscape dominated by genes that each are mutated in relatively few cancers.
10/5/07: Dr. Carol Greider in the News
Carol Greider Awarded 2007 Luisa Gross Horwitz Prise for Oustantding Contributions Understanding Telomeres. The awardees, who were recognized by the Lasker Foundation last year, are again honored for their work contributing to the understanding of telomeres and their role in cancer and stem cell failure.
10/4/07: Dr. Richard Huganir in the News
What Emotional Memories are Made Of. Both extensive psychological research and personal experiences confirm that events that happen during heightened states of emotion such as fear, anger and joy are far more memorable than less dramatic occurrences. In a report this week in Cell, Johns Hopkins researchers and their collaborators at Cold Spring Harbor and New York University have identified the likely biological basis for this.
10/1/07: Dr. David Berman in the News
Standard Treatment for Prostate Cancer may encourage spread of Disease. A popular prostate cancer treatment called androgen deprivation therapy may encourage prostate cancer cells to produce a protein that makes them more likely to spread throughout the body, a new study by Johns Hopkins researchers suggests.
9/27/07: New CMM Website Launched
Welcome to the new CMM website. This new site was designed and deployed by two second-year CMM students, ChangHee Lee and John Poirier, and Academic Program Administrator Leslie Lichter. The new website is based on the Mediawiki wiki engine. This system will allow easy content management and administration to keep student, faculty, and program information current.
9/10/07: Dr. Christopher Ross in the News
Mouse Model for Schizophrenia has Genetic ON-OFF Switch. Scientists at Johns Hopkins have developed a mouse model for schizophrenia in which a mutated gene linked to schizophrenia can be turned on or off at will.
9/7/07: Drs. Hongjun Song and Guo-li Ming in the News
How the gene that has been pegged as a major risk factor for schizophrenia and other mood disorders that affect millions of Americans contributes to these diseases remains unclear.
8/23/07: Dr. Pierre Coulombe in the News
Natural Chemical Found in Broccoli helps combat skin blistering disease. Johns Hopkins scientists have found yet another reason why you should listen to your mother when she tells you to eat your vegetables. Sulforaphane, a chemical present at high levels in a precursor form in broccoli and related veggies (cauliflower, Brussels sprouts, etc.), helps prevent the severe blistering and skin breakage brought on by the rare and potentially fatal genetic disease epidermolysis bullosa simplex (EBS).
8/2/07: Dr. Akira Sawa in the News
Hopkins Team Develops First Mouse Model of Schizophrenia.
Johns Hopkins researchers have genetically engineered the first mouse that models both the anatomical and behavioral defects of schizophrenia, a complex and debilitating brain disorder that affects over 2 million Americans.


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Figure skating, cinemagraph by Andrés Gallardo Albajar
This is my first approach to cinemagraph. Few days ago I got hold of a press pass for the Figure Skating Junior World Championships, and decided it's a good opportunity to make some gifs. I hope you like them. This girls are the future of ice skating. Andrés Gallardo Albajar: behance / website
Animated tribute to René Magritte by Raphaëlle Martin
Animated tribute to surrealist painter René Magritte Raphaëlle Martin: website/ behance
Cinemagraphs, animated photography by Julien Douvier
Cinemagraph Collection – August 2014 Filmed and edited by Julien Douvier Julien Douvier: website / behance / tumblr / facebook
Loving Vincent Film – bring Van Gogh's paintings to life
What is truly groundbreaking about "Loving Vincent" is that every frame of the film is an oil painting on canvas, using the very same technique in which Vincent himself painted. And what makes it a great story to experience is the intriguing, tragic, and inspiring story of Vincent Van Gogh himself. Imagine yourself in a...
Echelon 4, 3D collaboration between Konrad and Roland Dobson
Echelon 4 is the first 3D collaboration between Konrad and Roland Dobson
3D / Advertising / Animation / Commercials / Events / Music / Videos
Awesome 3D spectacle created by Nokia and deadmau5
On Monday 28th November 2011 Nokia Lumia 800 with Windows phone brought deadmau5 and the world's most advanced 4D technology together and created an amazing free light show at Millbank Tower, London.
The Hobbit: An Unexpected Journey videoblog, the production diaries by Peter Jackson
3D / Animation / Graphic Design / Movies / Videos
Maux-dits: a 3d short movie made by Antonin Sauvage, Fanny Rollot and Jerome Henrard
"Maux-dits is a team of three students at the Albert Jacquard College: Antonin Sauvage, Fanny Rollot and Jerome Henrard. This project is our final work for graduation."

subset: commoncrawl


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TexMetals.com review
Click here to submit your review.
A Fine Comany
TPM only sells what they have in stock and always provides fast, prompt service. They've been a LIFESAVER when it comes to trading in the worthless paper Jamie Dimon and Lloyd Blankfein pay me into shiny gold bullion. Can't wait to GTFO of DC and let Old Yellen take the reins of this b*tch!!
The Best Prices on the web!
TexMetals.com offer the best prices on bullion. They sell it all! Silver, Gold, Platinum and Palladium. Shipping price is very fair and is very quick. I would suggest purchasing from TexMetals.com for all of your bullion needs! They are simply one of the best!
The Best Prices on all products!
TexMetals.com offers a great selection with great prices! TexMetals.com has everything you could possibly want at extremely low prices! Shipping is fast and is free on orders over $6000!
Used this company on a recommendation from my Father in-law. He is happy with every transaction he has had with them but I am not. They have very snarky customer service when you can actually get a real person on the phone. I received a crushed box through the postal service and asked for a return without actually opening the box and the made it next to impossible. Anyway I would never use them again


text:
Narrow your search
If you're a fan of the other Arkham games, you're going to really enjoy Arkham Knight, even if there's a handful of stuff you've seen before. The Batmobile and a number of new ideas and mechanics freshen the overall experience and the game's powerful brand of storytelling provides a satisfying connection between the in-game action.
Batman puts the pedal to metal on Gotham's roads in the latest instalment of the award-winning Arkham videogame series.
Batman: Arkham Origins is still the great superhero game you've played before, but it doesn't do much to move the franchise forward.
The Wii U-specific additions put a few chinks in the Caped Crusader's costume, but Batman: Arkham City - Armored Edition is still a great action adventure game.
The venerable comic book maker has inspired movies, television shows and video games. Now, for the first time, the trend is working in reverse.
Warner Bros. Interactive Entertainment voluntarily pulls the latest Batman game off the digital distribution platform after outcry from disappointed gamers.
As we hurtle towards the eighth anniversary of the first iPhone going on sale, we look back at why Apple's first smartphone succeeded. Plus, there's more great tech news and your feedback.
Ten years ago, Christopher Nolan's vision of a darker Batman hit the screens. Enjoy the best moments from his three films in this 10-minute montage.
A new video recolours "Man of Steel" into "a Superman movie that looks like Superman!"
Between Season 5 of "Game of Thrones" and two new trailers to please both sci-fi and superhero fans, the CraveCast crew can barely contain themselves.


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Need help with finding info on '62 Honda CR72 Prototype
We have been doing some research on the '62 Honda CR72 Prototype and have met with minimal success. It has a one off twin cam 4 valve engine with chain driven cams not gears like all of it's successors. The engine was stuffed into a CB72. Presumably this was done for testing to be sure the concept worked before going into "production". Allegedly Honda had a US serviceman race it for a short time while serving his tour in Japan. It disappeared after that. It was rumored that he brought it to the US when he returned from duty.
To date one photo has turned up and that being in a Japanese bike magazine.
The top bike is the prototype CR72 and the bottom bike is one of variations of the "production" race bike.
If you know of any pictures or information about this bike or know someone who knows someone.... your help would be greatly appreciated in helping piece together the history of this motorcycle.
Thanks in advance
Man, good luck with that.
Anybody seen Mike's needle?
I wish the needle we're looking for was even close to that size. :lol3
I had heard of that bike but never seen any pictures of it. I am sure you have tried the 305 message board but if you havent check it out and find LOUDMOUSE(Ed I believe his name is),he seems to be the "go to guy" for obscure CB/CL 72-77's info. Also you may wanna try Team Hansen,Bob Hansen(RIP) was the head service guy for Honda America in the '60's IIRC he passed away a few years back but the company is still going and they may be able to point you in a direction.
Please keep us updated on what ya find I myself ride and road race CB77's and would like to know what you find.
I have a friend who owns a CR72 racebike. He's mentioned a road-going prototype, and I believe he said it ended up in the US.
I'll ask him about it next time I see him.
What treasures are uncovered on this meandering path will get posted. :thumb
*edit* this is part of an edited email I received from Ron, the other part of we.
crikey! This is the first I've heard of Bob's passing.
I met him at the On Any Sunday reunion movie in about 2005.
Very nice guy, very humble about his influence on motorcycling. (some give him credit for popularizing the across the frame four that's so common today)
CR72 prototype
The bike is currently in the hands of an excellent restorer in southern California. You can expect to see it in national vintage shows in the not too distant future. It is not mentioned in any history books, and Honda professes not to know anything about it. Engine photo here: http://community.webshots.com/photo/...29466406JUrOLX
You know more than you are saying. :deal
welcome to the asylum. :wave
a couple of things
1. fill out your profile :mully
2. fetch me a beer. :1drink
3. who the hell are you? :poser if you know where the bike is you must know me also. a reply via pm would be fine. k, thanks.
ps: thanks for bumping this, been meaning to update it.
We are still in the hunt for more of the history of the bike.
To date not much more of the history has been uncovered. There was contact (though a series of contacts) with a person who was/is involved with Honda that stated there are no records of the bike, rumors, but no records and ended with a response equivalent to "how the hell did you get your hands on it".
So we are still trolling around in the hope that someday, somehow, someone has new information. :lurk
Here are a few pics of (some of) the bike at this point.
The original frame had disappeared long ago and the frame that was used was junk.
So mods were made to adapt the proper frame to the engine as Honda had originally done.
The replacement tank also needed to altered to clear the larger head.
As the project moves along, in the hopes of keeping this troll for information alive, I will give an occasional update on the progress.
Thanks for your participation.
ps: I originally posted an incorrect model id, the cb250 came to be few years later. At the time I was not concerned about it as I was trolling for participation and any to get a response of any kind seemed except-able at the time. :D
Hold up,is this your project?
Yes and No. I don't have the honor of owning it, I just have the honor of doing repairs/fabrication. It belongs to a friend, Ron Mousouris.
Any progress?
Last weekend I stopped by to see Ron and what he was up to and what it was he had for me to do next and totally spaced on getting some pictures. :baldy
He is cleaning up the engine and starting to assemble it. The frame has had the ground coats applied and some parts have gone out for plating. Ron is very thorough and not very fast. That and having 4 Benly J's, a CB77, this bike in midrestoration and his track bikes to mess with and there is his injection molding business to run, there's also something else I've forgotten. To say he's spread a little this might be an understatement. :lol3
This coming weekend I have to pick up the CR72 tank to make mods to clear the velocity stacks and some other parts for the Benly J's so I work on getting get some pics then.
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Worst Pieces of Advice I've Ever Received
Worst Pieces of Advice I've Ever Received
As I review the past six decades, I've received more than my fair share of advice—occasionally even solicited. But of all the advice I've ever received, these 15 stand out as amongst the worst. They are in more or less reverse chronological order, although the well-meaning but misguided wisdom they display has proven to be timeless.
Carol Orsborn is Founder of FierceWithAge, the Digest of Boomer Wisdom, Inspiration and Spirituality. Dr. Orsborn is the best-selling author of 21 books including her newest book: Fierce with Age: Chasing God and Squirrels in Brooklyn. (Spring 2013) With a doctorate in religion from Vanderbilt, Dr. Orsborn is a sought after speaker/retreat leader and spiritual director.
Hollywood Faith Facts: Marvin GayeSoul legend Marvin Gaye led a life that many only dream of. His early Christian...
Success Sundays: Debbie Sterling, Founder of GoldieBloxGirls like to play with more than just dolls and dresses - and Debbie Sterling...
5 Spiritual Vacations That Will Elevate Your FaithNeed a getaway? Take a cruise that will bring new life to your spirit, draw...
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Professional Ratings: 94 Wine Spectator, 94 Wine Enthusiast
Region: Chile, South America
Varietal: Bordeaux Red Blends
Other Info: Collectible Wines, Great Wine Gift
Item no. 86374
Wine Spectator Top 100 of 2006!
Clos Apalta is the ultimate expression of Casa Lapostolle's dedication to quality made from the best grapes from our Apalta vineyard. This wine, not produced every year, is a belnd of Merlot, Carmenere, and Cabernet Sauvignon from 60-100 year old pre-phylloxera vines.


text:
Join OkCupid
Find better matches with our advanced
Find better matches with our advanced
matching system
—% Match
—% Enemy
41 • Sulphur Bluff, TX • Man
I'm looking for
- Women
- Ages 18–49
- Located anywhere
- Who are single
- For new friends, long-term dating, short-term dating, casual sex
My details
- Last online
- Apr 14
- Orientation
- Straight
- Ethnicity
- White
- Height
- 6′ 3″ (1.91m)
- Body Type
- Average
- Diet
- Strictly anything
- Smokes
- No
- Drinks
- Often
- Drugs
- Never
- Religion
- Other, and very serious about it
- Sign
- Capricorn, but it doesn't matter
- Job
- Other
- Status
- Single
- Offspring
- Doesn't have kids, but might want them
- Pets
- Has dogs and dislikes cats
- Speaks
- English (Fluently), Spanish (Poorly)
My self-summary
Write a little about yourself. Just a paragraph will do.
I am a 41 year-old male. Once married now single again, no children (yet, might be nice someday but not now). I am a "country boy", never have liked city living aside from some work and play. I am a survivalist who believes that the best method of making it through any disaster is preparation , though I try not to go to extremes with it. I pride myself on my skills, I grew up hunting, fishing, tracking & trapping. I have spent weeks at a time out in all sorts of weather conditions with next to nothing in the way of supplies. Survival training in sub-arctic temperatures on up to temperatures you would likely only see in Death Valley's Furnace Creek area. Some consider me to be overly intense, others seem to think I am rather laid back; personally I believe the truth to be somewhere in the middle. I like to think I am a fun person to be around, the nutcases aka my friends seem to think I am fun to be around. Due to the types of work I have done and due to where many friends live, I have traveled all over the US and I still enjoy traveling. I enjoy the outdoors (camping, hunting, fishing, tracking, trapping) though there are times I would much rather be kicked back at home in front of a fireplace telling stories. I have to admit I enjoy doing stupid things at high speed. I have raced cars, trucks, motorcycles, etc in the past and given the chance to do it again I would. I willingly take risks with my own life as I am a firm believer that you can't live in fear of death as if you do you will never truly live. I admit it hasn't always worked out as planned but if you take no risks in life you are not really living.
What I'm doing with my life
Don't overthink this one; tell us what you're doing day-to-day.
Trying to live life to its fullest regardless who doesn't approve of my choices and methods.
I'm really good at
Go on, brag a little (or a lot). We won't judge.
I am good at working with my hands; metalworking, woodworking, automotive work, electronics. I am good at camping, hunting, fishing, tracking, trapping, cooking and surviving in environments many find inhospitable.
Favorite books, movies, shows, music, and food
Help your potential matches find common interests.
I enjoy reading science fiction, fantasy, horror and given an interest in the particular subject matter educational material.
My taste in movies leans largely towards my reading preferences, however I do have to admit my favorites are horror movies.
I enjoy exploring different cultures through their cuisine. I will try almost any type of food once. Though growing up in Tx and spending time on the bayou in Alabama & Louisiana, I have a fondness for Mexican, TexMex and Cajun foods.
My taste in movies leans largely towards my reading preferences, however I do have to admit my favorites are horror movies.
I enjoy exploring different cultures through their cuisine. I will try almost any type of food once. Though growing up in Tx and spending time on the bayou in Alabama & Louisiana, I have a fondness for Mexican, TexMex and Cajun foods.
I spend a lot of time thinking about
Global warming, lunch, or your next vacation… it's all fair game.
Honestly I have a tendency to wonder why all I have to do is say oops and friends & family alike run like hell but if I am working on something and cussing everyone wants to come over and look. Aside from that I spend a lot of time wondering what the future holds and trying to plan for it.
You should message me if
Offer a few tips to help matches win you over.
You should message me if you like what you see in my profile here and think we could have fun together.
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7900 GS performance issues
Hello. I'm currently running Kubuntu 7.04 beta, but my problems go back even to when I had Ubuntu 6.10 installed. I've tried 64-bit and 32-bit OS'es and drivers, but I'm having some serious issues. I also looked through as many forum threads as I could find, but I still don't have any answers as to why my performance has dropped so significantly with this new 7900 GS installed. The only article that may have shed some light is the following one that says XGL isn't supported with the 7900 GS. If that's the problem, any time frame on when it will be fixed? Anyway, here's that article.
As for my video problems, my computer specs have remained the same except for three upgrades. My previous hardware components where a Pentium 4 3.06 GHz on an Intel 845PE chipset motherboard and an AGP 6800 GT. My new hardware is a Pentium D 2.66 GHz on a VIA PT880 Pro/Ultra chipset motherboard and a PCI-E 7900 GS. In the first configuration, I would get roughly 52 fps in Doom 3 under linux and about 53 or 54 fps under windows. In my new configuration, I get around 53 fps under linux (on a clean install btw) and about 70 fps under windows! I am at a total loss as to why my performance has taken such a drastic hit. I even enabled the coolbits option and sure enough, my card is running at the appropriate speed. If it'll help, here's my xorg.conf file that the nvidia-xconfig program made.
# nvidia-xconfig: X configuration file generated by nvidia-xconfig
# nvidia-xconfig: version 1.0 (buildmeister@builder3) Mon Feb 26 23:38:46 PST 2007
# nvidia-settings: X configuration file generated by nvidia-settings
# nvidia-settings: version 1.0 (buildmeister@builder3) Mon Feb 26 23:39:38 PST 2007
Section "ServerLayout"
Identifier "Layout0"
Screen 0 "Screen0" 0 0
InputDevice "Keyboard0" "CoreKeyboard"
InputDevice "Mouse0" "CorePointer"
Section "Files"
RgbPath "/usr/X11R6/lib/X11/rgb"
Section "Module"
Load "dbe"
Load "extmod"
Load "type1"
Load "freetype"
Load "glx"
Section "ServerFlags"
Option "Xinerama" "0"
Section "InputDevice"
# generated from default
Identifier "Mouse0"
Driver "mouse"
Option "Protocol" "auto"
Option "Device" "/dev/psaux"
Option "Emulate3Buttons" "no"
Option "ZAxisMapping" "4 5"
Section "InputDevice"
# generated from default
Identifier "Keyboard0"
Driver "kbd"
Section "Monitor"
# HorizSync source: edid, VertRefresh source: edid
Identifier "Monitor0"
VendorName "Unknown"
ModelName "Mag InnoVision"
HorizSync 30.0 - 86.0
VertRefresh 50.0 - 160.0
Option "DPMS"
Section "Device"
Identifier "Videocard0"
Driver "nvidia"
VendorName "NVIDIA Corporation"
BoardName "GeForce 7900 GS"
Section "Screen"
Identifier "Screen0"
Device "Videocard0"
Monitor "Monitor0"
DefaultDepth 24
Option "metamodes" "1280x1024_75 +0+0; 800x600 +0+0; 640x480 +0+0"
Option "Coolbits" "1"
SubSection "Display"
Depth 24
Modes "1600x1200" "1280x1024" "1024x768" "800x600" "640x480"
Please help me out with this if at all possible. I really would like to get my video card performing up to par under linux, but I have no idea what's going on. I even checked all the libGL.so and libGLcore.so files, and everything appears to check out correctly. I'm currently using the 9755 drivers, but even rolling back to the 9746 drivers resulted in the same results. Thanks for any help you can give me.
Re: 7900 GS performance issues
Re: 7900 GS performance issues
1 Attachment(s)
Hopefully you were requesting that I post a copy of the bug report. If so, here you go. As for looking at other threads, I have tried to do that and nothing seems to either match the same problem I'm having or have any resolution at present. Thanks for any help.
Re: 7900 GS performance issues
Can you clarify where the performance drop is? According to your description the performance has either remained the same or improved.
Re: 7900 GS performance issues
Sure, I can try and explain it again. My previous CPU was a P4 3.06 GHz and my video card was an AGP 6800 GT. In Doom 3 in particular, I would get 52 fps using the built-in timedemo. With that same hardware under windows, I would get around 54 fps or so. As you can see, performance was pretty close. Here is where my problem lies. I upgraded to a Pentium D 2.66 GHz processor and a PCI-E 7900 GS. All of the other hardware (except motherboard) is the same. The cpu and video card are obviously superior, however, my performance under linux is usually in the 49 to 53 fps range and it will only hit 53 when I overclock my CPU to 2.9 GHz. This same hardware under windows will pull in 70.5 fps! We're talking over 15 fps difference now whereas previously the difference in performance was only about 2 or 3 fps at the most.
If I were to reinstall the AGP 6800 GT, I guarantee my performance would be higher than the 7900 GS, and that's just not right. There's no way a slower video card with less pixel pipes and core speed amongst other factors should be performing better under linux. I'm no linux guru by any stretch of the imagination, so if there's any more detailed info that I can give you, I'll be happy to do so. I just don't know where to go looking other than the xorg.conf and the bug report log. This is a clean install of linux and no resident information from my previous video card remains. Thanks.
P.S. -- my motherboard is a bit special in that it can support both AGP and PCI-E, but the PCI-E is electrically limited to 4x speed, but that's the same AGP speed my 6800 GT was running at.
Re: 7900 GS performance issues
PCI-E x4 is not the same speed as AGP 4x.
Have you actually reinstalled the 6800GT to verify that the performance is higher?
Re: 7900 GS performance issues
Ok, I reinstalled the 6800GT and tested both video cards out with the same 9755 32-bit drivers. I received 54.1 fps at AGP 4x and 54.5 fps at AGP 8x with the 6800 GT. Just a gee wiz thing there with the difference in 4x/8x speed. Anyway, I have the 7900 GS reinstalled now and I got 54.6 fps with it. I might have got a slight increase on the 7900 due to enabling AGP fast writes, but I don't understand why that would be. Either way, you can see that the performance with the two video cards is identical for all intents and purposes. Is this normal under linux? Certainly that isn't the case. Any more info you could use? I have the xorg.conf and nvidia-bug-report from the 6800 if that would be of any use.
*EDIT* -- Just thought of something. I just installed some updated xserver-xorg-dev files and whatnot today for Kubuntu 7.04 before playing musical video cards. That could be what gave me a slight performance boost with the 7900.
Re: 7900 GS performance issues
Did you test performance in the new motherboard with the 6800 card as well?
Its possible that you're hitting some kind of motherboard kernel driver issue.
Re: 7900 GS performance issues
My last post was all on the same motherboard. The only difference between the tests now is the video card being used. Everything else is identical. As far as a motherboard kernel issue, I have absolutely no idea how to check that. I can tell you what chipset I'm using, but I don't know much about building linux kernels or how to configure them. I'm running a VIA PT880 Pro/Ultra. Does that help any?
Re: 7900 GS performance issues
hm. can't delete messages! :O
Re: 7900 GS performance issues
I was going to put this issue to bed, but I accidentally stumbled upon something very interesting. You see, I was going to write everything off as a possible linux kernel issue. Just to sate my curiosity however, I decided to install the linux version of Quake 4 and benchmark it as well. Since it's based off of the Doom 3 engine, I expected the scores to be abysmal, right? Wrong! Here were my Quake 4 settings when I noticed something was up...
1280x1024, High Quality, 2x AA, SMP enabled --> 61.71 fps
Seeing that, I was a bit shocked. Those same settings under Doom 3 (minus SMP) gave me 55.2 fps. That's right. Quake 4 was outperforming the supposedly less intensive Doom 3. Here are the side by side scores for Quake 4 on Windows vs. Linux.
Windows, 1280x1024, High Quality, 4x AA, SMP --> 57.77 fps
Linux, 1280x1024, High Quality, 4x AA, SMP ------> 56.66 fps
THAT is the kind of performance that I'm used to seeing. Linux being within one or two fps of windows performance. To further test my theory, I did a slight overclock on my 7900 GS. 510 core/700 memory. Doom 3 performance DROPPED from 55.2 fps with 2x AA to 53.8 fps! Predictably, Quake 4 performance went up to 57.20 fps with 4x AA. These two programs are really the only things I have to benchmark linux performance, but it is apparent now that there is an issue there with Doom 3. I'm not certain if it's just the linux version of Doom 3 not working well with my motherboard or if it's the nvidia drivers. Personally, I'd bet on Doom 3 being buggered up.
Sorry to bother you with all of my troubles netllama, but I'm happy knowing that my 7900 GS is performing up to specs after all. Guess I'm down to just one reliable 3d benchmark in linux now, but that's not so bad I guess. Thanks for your help. Take care. :)
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by Heather Doney cross posted from her blog Becoming Worldly This is a post for homeschooling's "old guard," the people who first started homeschooling and unschooling back in the day. Writing this post has been hard to do. I do not want to make enemies of the old guard unschoolers and homeschoolers. I just want them to do the right thing. … [Read more...]
To Homeschooling's "Old Guard:" 20 Truths You Need to Hear
May 31, 2013 by Suzanne Calulu
Filed Under: 49 Character Qualities, Accountability, Alienation, Beautiful Girlhood, Becoming Worldly, Biblical Manhood & Womanhood, Big Happy Family Vision, Blaming the victim, Botkin Syndrome, Boundaries, Bounded Choice, Child Abuse, Child Labor, Child Protective Services, Christian Apologetics, Coercive Religious Groups (Cults), Confession, Contentiousness with other Christians, Control, Controlling Emotions & being cheerful always, Creation Science / Creationism, Demanding Abuse Answer from HSLDA, Demonic Influences, Dominionism / Christian Reconstruction, Drinking the Koolaid, Educational Neglect, Elitism, Emotional Incest, Emotions, Enmeshment, Father Worship, Fear Based Theology, Fear of Government, Fear of Hell, Fear tactics, Feminists, Formulaic Religion, Fruit of the Spirit, Fundamentalism, Gender Equality, Grieving, Group Think, Homeschool, Homeschoolers Anonymous, Homeschooling World - Mary Pride, Homeschooling's Invisible Children, Hot Topics, How Did I Get In This Mess?, HSLDA, Isolation, Issues, Judgementalism, Learned Helplessness, Legalism, Maintaining Appearances, Manipulation, Markers of a Cult, Marketing "Biblical Family Values", Mental / Emotional Health, Must Read! ~ NLQ Readers Choice ..., NLQ Miscellany, NLQ Open Comments, NLQ Quote Worthy, NLQ Stories, Parentification of Children, Patriarchy, Patrick Henry College, Perfectionism, Personal Autonomy, Public Schools, Purity Culture, Quiverfull, Quiverfull Counterculture, Quiverfull Discernment, Quiverfull Discernment Websites, Quiverfull in the News, Quiverfull Ministries, Quiverfull Topics, Rape Culture, Recovering from Spiritual Abuse, Religious Trauma Syndrome, SASBN, Self Esteem, Self Medicating, Self-Abnegation / Martydom, Self-Preservation Factor, Self-Righteousness, Socialization, Spiritual Abuse, Spiritual Abuse & Recovery, Spiritual Abuse Survivors, Spiritual Issues, Stay At Home Daughters (SAHDs), Submission, Teen Missions, The Godly Woman, The Myth of Teenage Rebellion, The Spiritual Abuse Survivor Blogs Network, Uncategorized Tagged With: Child Abuse and Neglect, Demanding Answer from HSLDA, Homeschool Survivors, homeschooling, Homeschooling abuse, HSLDA
Quoting Quiverfull: Fear of Any Government?
May 31, 2013 by Suzanne Calulu
by Vaughn Ohlman from Perservero News - Imaginary Money and Fairy-Tale Business Take the minimum wage… one of the many issues that is destroying the South African economy. The government thinks that by telling people that they have to pay people more, that, somehow, people will make more. But in reality … [Read more...]
Filed Under: Accountability, Alienation, Atheists, Biblical Manhood & Womanhood, Big Happy Family Vision, Birth Control, Birth control, Blaming the victim, Coercive Religious Groups (Cults), Complimentarianism, Confession, Control, Democrats, Demonic Influences, Dominionism / Christian Reconstruction, Drinking the Koolaid, Elitism, Father Worship, Fear Based Theology, Fear of Government, Fear of Hell, Fear tactics, Feminists, Formulaic Religion, Fruit of the Spirit, Fundamentalism, Group Think, Isolation, Issues, Judgementalism, Legalism, Manipulation, Markers of a Cult, Marketing "Biblical Family Values", Marriage Covenant, Mental / Emotional Health, More from NLQ ..., NLQ Miscellany, NLQ Open Comments, Non-Evangelical Christians, Old Paths, Other Religions, Patriarchy, Perfectionism, Perservero News, Personal Autonomy, Pro-Life, Psalm 127 / Quiverfull: Be Fruitful & Multiply, Quiverfull, Quiverfull Counterculture, Quiverfull Discernment, Quiverfull Ministries, Quiverfull Topics, Quoting Quiverfull, Raising the minimum wage, Religious Trauma Syndrome, Self Esteem, Self-Abnegation / Martydom, Self-Righteousness, Spiritual Abuse, Spiritual Abuse & Recovery, Spiritual Issues, Submission Tagged With: business, Fear based theology, Fear of Government, Fear tactics, Raising the minimum wage


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Originally written on Fox Sports | Last updated 6/22/13
At this point, the controversy surrounding the Washington Redskins' team name isn't going away any time soon. While the name, which detractors say is flatly a racial slur, has drawn ire for years, the controversy was reignited in earnest back in January, when Washington Mayor Vincent C. Gray called upon the team to change its name. The team subsequently replied that it had no plans to change the name and launched a campaign defending its use. Later, owner Dan Snyder came out and defiantly said the team would never change its name, while even some members of Congress called upon Washington to drop its moniker. At one point, franchise quarterback Robert Griffin III seemed to tweet in support of the name, while NFL commissioner Roger Goodell defended it in a reply letter to Congress. Oh, and all the while, a national poll claimed widespread national support for the Redskins. Does that about sum it up? Now, franchise icon Joe Theismann is weighing in on the matter, and he has a very ...
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text:
SQL backup scheduling question
The schedule I use currently is depicted in the attached image. The difference b/t each of the schedules is the Frequency/retention time. It's been and still is working just fine.
But question is whether it's necessary to have all of the different "Automatic" schedules for each of the "Application" back ups, or could we somehow have one "Automatic" schedule that was 24x7? I ask b/c the attributes for the "Application" backups don't appear to allow me to specifiy a frequency, so I don't see how I could get the results I'm after w/o having a separate corresponding "Automatic" schedule for each "Application" backup that requires a unique frequency; short of creating a separate Policy for each.
Comments 4 Comments • Jump to latest comment
You have done a great job of scheduling. The alternative would be to create separate policies (as you figured out) which is cumbersome. The descriptions of the backup types are below.
SQL Server backup types
Backup type Description
Application Backup
The Application Backup schedule enables user-controlled NetBackup operations from
the client. These operations include those initiated from the client and those initiated
by an automatic schedule on the master server. NetBackup uses the Application Backup
schedule when the user starts a backup manually. Configure at least one Application
Backup schedule for each database policy. The Default-Application-Backup schedule is
configured automatically as an Application Backup schedule.
Automatic Backup
An Automatic Backup schedule specifies the dates and times for NetBackup to
automatically start backups. NetBackup runs the scripts in the order that they appear in
the file list. If there is more than one client in the policy, the scripts are run on each
MS-SQL Administrator Guide, page 36
Doug Snyder
Technical Architect 5
Columbus, Ohio USA
We prefer different policies for different retentions.
Have a look at this discussion:
This TechNote says it can be done in one policy:
Create different Application Backup schedules with different backup windows.
Please note that it is very important the two "Backup Policy" schedules do not overlap. If they do overlap, unpredictable results can occur, and backups could fail to take place or could expire prematurely.
This is why we have gone for the different policy per retention period.
Supporting Storage Foundation and VCS on Unix and Windows as well as NetBackup on Unix and Windows
Handy NBU Links


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Egyptian protesters reject army offer
Thousands of Egyptians have continued to occupy Cairo's Tahrir Square despite an offer from the military for a speedier handover to civilian rule, the BBC reports.
After four days of violent clashes, Field Marshal Mohamed Hussein Tantawi said presidential elections would be held by July 2012.
But many protesters in the square said the concession was not enough and have demanded the field marshal step down.
Clashes continued between police and protesters in Cairo early on Wednesday.
Television pictures from Tahrir Square showed ambulances arriving to pick up the injured.
At least 30 people have been killed since Saturday and hundreds injured, officials say.
Police have been using tear gas, rubber bullets and birdshot against protesters who have been throwing stones.
Some protesters said live bullets had been fired.
There have also been clashes in several Egyptian cities including Alexandria, Suez, Port Said and Aswan.
Egypt's ruling military council had previously said presidential elections might not happen until late 2012 or 2013. That move, coupled with a draft constitution produced earlier in the month that would exempt the military and its budget from civilian oversight, prompted a mass demonstration in Tahrir Square on Friday.
Events turned violent when security forces attempted to remove the protesters from the square on Saturday.
We enjoin our readers to send their reports, including pictures to [email protected]
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What Boko Haram and NADECO have in common
As we watched troubled President Goodluck Ebele Jonathan in his black kaftan with black cap behind the distraught emir of Kano last week, it was ... Full story


text: by Jim Boyle Editor Parents looking for child-friendly businesses have an eye care center in Otsego they can count on. Bright Eyes Vision Clinic prides itself on its child-friendly atmosphere. "We strive to be a place that parents can bring their children and feel comfortable," Dr. Jill Schultz ...Read More


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Amniocentesis is a procedure that lets doctors detect or rule out problems with your babies health long before birth.
In the uterus your baby is surrounded by amniotic fluid that provides protection and nourishment.
Floating in the fluid is cells from your baby providing doctors with genetic material for testing.
In amniocentesis your doctors will take a sample of this fluid to test for specific genetic disorders and birth defects.
Amniocentesis is usually done in the 2nd tri-mester of pregnancy at 15 to 18 weeks.
It is generally offered to women with certain risk factors.
Age 35 and older, which increases the risk of chromosomal disorders such as Down syndrome.
A previous child or pregnancy with a birth defect.
Blood test or ultrasound suggesting a birth defect such as down syndrome or neuro-tube defects
Or a family history of birth defects such as cystic fibrosis.
Amniocentesis may also be done in the 3rd tri-mester for these reasons.
To determine if the baby's lungs are mature enough should early delivery becomes necessary.
To diagnosis a uterine infection.
Or To check for anemia in a baby with RH incompatibility.
To begin the procedure the doctor would use an ultrasound to create an image of the fetus and nearby structures on a computer screen.
Looking at this image the doctor can choose a safe place to insert the needle.
Your doctor may give you an injection of local anesthesia to numb the surface of the abdomen where the amniocentesis needle is to be inserted.
Carefully watching the ultrasound monitor to avoid contact with the placenta or the baby,
your doctor will introduce the thin needle through your abdominal wall into your uterus and into the amniotic sack.
He or she will with draw a small sample of amniotic fluid, remove the needle and cover the site with a bandage.
Your body will make additional fluid to replace what was removed.
Your doctor will continue to monitor the ultrasound to check that the fetal heartbeat is normal and the baby tolerated the procedure well.
You may feel mild cramping or pressure in your lower abdomen.
For about 24 hours after the procedure you will be advised to avoid physical stress such as vigorous exercise, lifting, prolong standing , and sexual activity.
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Originally written on Puck Drunk Love | Last updated 3/27/13
The good news: Jamie McBain scored a goal in his team's 4-1 defeat against Winnipeg. The bad news: Jamie McBain's goal went into his own net. As McBain desperately tried to clear the puck from the front of his net, he swung at the puck, missed it, and knocked the puck into his own net when he brought his stick back to the ice. It's safe to say that Evander Kane, the player that was credited with the goal, might not ever score an easier goal in his NHL career. There are accidents in hockey and then there are great, big blunders like this one. It's safe to say McBain was either trying to knock the puck into the corner or right his stick so he could wrist the puck out of the zone, but the end result was a shot on his own net that caught goaltender Justin Peters by surprise. Have you ever seen someone try to shoot a puck that's never picked up a hockey stick before? Most times you'll see them whiff when trying to strike the puck, only to bring the stick back and accidentally hit it in the opposite direction. That's what McBain looked like on his attempted clearance that ended up lighting the lamp. [follow]
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This really had a profound effect on me:
"It really messes you up," he said. "It's incomprehensible the way human beings can slaughter each other in front of you. And you take it home with you. And it's like you haven't cleaned your teeth in several months, it leaves a bad taste in your mouth."
It's almost impossible to be empathetic and try to understand what McCullin must be going through... Wow.