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Ask Better Homes & Gardens
Experts and BHG readers answer.
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What is an organic solution to kill Creeping Charlie without damaging the grass or contaminating our well water in a large yard?
From your description I doubt you have violets. It sounds to me like creeping Charlie. This low-growing, aggressive member of the mint family has roundish leaves and purple flowers in spring. It's a tough, invasive weed, especially in shady spots. You have three primary options, all of which have drawbacks. Hand-pulling. For large infestations, forget it! But if you spot it early, you can probably manage to eliminate creeping Charlie by hand.
Herbicide. Find a three-way weed killer (for example, one with Trimec in it) and use it a couple of times in spring or fall, when the soil is moist and growing conditions are good. The key is repeat applications a couple of weeks apart; one application alone will fail. Another option is glyphosate (Roundup). If applied directly to the plants' foliage, the nonselective herbicide does not go into the soil, so it should not affect your groundwater. It's designed to get inside the plant and kill it from the inside out. Glyphosate kills the grass, too, so you'll need to start new grass in treated areas.
Borax. If you apply it in the right amount, household borax is slightly more toxic to creeping Charlie than to grass, so you can kill the weed but spare the lawn. It does have its limits: It's going to burn the grass if you apply it too heavily, and you can apply it only once a year for 2 years before you exceed the level that will harm grass. The proper mixture is 10 ounces of borax in 21/2 gallons of water for 1,000 square feet of infested lawn.


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Shows how to get dramatic lighting results by using just one or two detached strobes that are triggered remotely by a digital SLR.
Shows photographers how to use fill flash to take great shots in any kind of lighting.
"I almost feel as if I am in a classroom but with the benefit of sitting at my home computer." —Christine B.
more from our members »


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- Noon
- Strolling lunch
- 1:00pm
- Welcome
- 1:15pm
Dave Mondragon,
General Sales Manager for Ford & Lincoln, Ford Motor Company
Dave Zuchowski,
President & CEO, Hyundai Motor America
- 2:15pm
Panel Session: Compensation
A discussion concerning employee compensation, benefits, retention and turnover. An overall analysis with data from all regions of the U.S., based on 350,000 payroll records submitted by 2,500 dealerships.
- Bill Berman, President, Western Region, AutoNation
- Dean Fitzpatrick, President, Larry H. Miller Dealerships
- Andrew Shaver, President, Shaver Auto Group
- 3:00pm
- Break
- 3:15pm
Panel Session: The Workplace Skill Set
How do you retain employees in an ultra-competitive world? A lesson in retention from some of the best dealers in the country.
- Greg May, Dealer Principal, Greg May Chevrolet
- Mitch Walters, President, Friendship Enterprises
- John Yark, President, Yark Automotive Group
- 4:00pm
Jason Dorsey, Gen Y Guy(r)
Known for his data-driven approach to strategy, Jason has spoken or consulted with many of the largest dealer groups in the country. He is the authority on Gen Y and Millennials in the automotive industry. His newest books include Y-Size Your Business and My Reality Check Bounced!
- 5:00pm
- Conclusion of afternoon program. Networking reception begins.
- 6:30pm
- Dinner
- 7:45pm
- Gala Awards Presentation
- 9:00pm
- Afterglow celebration
- 10:00pm
- Conclusion


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Crowds of locals lounging under roadside tarpaulins, blasting their stereos and barbecuing four-course meals—no, it's not squatters or a sudden outbreak of homelessness, just the start of camping season, Bermudian-style.
Crowds of locals lounging under roadside tarpaulins, blasting their stereos and barbecuing four-course meals—no, it's not squatters or a sudden outbreak of homelessness, just the start of camping season, Bermudian-style.
Hilina Pali Road is not a pleasure ride, as the road is rough but passable. For most it probably isn't worth the time, but for those looking for isolation and a special vantage point, this could be it.
Stretching the length of the island, the Railway Trail provides a serene 20-mile artery through Bermuda's parishes, safely away from trafficked thoroughfares. Try two of the best sections on foot or bicycle.
Many of the sights on the Hawaiian Islands are a combination of history and beauty, and the same holds true for sightseeing in Koloa, Kaua'i. Two of Koloa's main sights to see give visitors a deeper understanding of the town's heritage, which in turn deepens appreciation of wandering its lovely landscapes.
Everybody's idea of a pristine Hawaiian valley is viewable at 'Akaka Falls State Park, one of the most easily accessible forays into Hawai'i's beautiful interior. Many varieties of plants that would be in window pots anywhere else are giants here, almost trees.
Zipline rides are booming on the Big Island. While there's lots of competition between companies on the Hamakua Coast for the best course, there's only one certified provider. Constructed in partnership with certified engineers, this course guarantees the utmost safety for zipliners.
In the mood for some weird and downright strange sights? Well, if you're in Austin, there's plenty to see. From the macabre to the astonishing to the just plain 'what the heck?', these locales and landmarks will definitely hit the spot.
Lana'i has plenty of hiking trails and most have something extra to offer such as unique archaeological sights or a bit of island history. The trails tend toward rugged, and there are a few that require planning ahead unless you're eager for a challenging return trip.
Nowhere else in Hawaii can you find waters as clear as those in Molokini Crater, a half-submerged volcanic caldera that rises from 300 feet of water. Snorkeling at Molokini is such a popular activity that if you want as much water to yourself as possible, you had best plan ahead to get there as early as possible on one of the smaller available charters.
Like the old town of St. George's in the East End, the Royal Naval Dockyard on Bermuda's western point is crucial to understanding what shaped the political and social history of Bermuda. It's also loads of fun to visit.


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Updated 05/15/2014
Frederick Philipse I, a wealthy Dutch merchant, began building this house in the 1680s. After the Revolutionary War his great-grandson Frederick Philipse III, a loyalist to the British Crown, had to leave behind the house and a 52,000-acre estate stretching from the Bronx to Croton. The home, the oldest in Westchester County, includes some of the finest surviving examples of American rococo architecture and decor.
29 Warburton Ave., Yonkers, New York, 10701, United States
Website: nysparks.state.ny.us
Sight Details:
Updated 05/15/2014
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Through her first album, Kacey Musgraves became known for her exceptionally truthful, rebellious lyrics as well as her own unique style. With numerous Country Music Awards — as well as a few Grammys — under her belt, her hard-hitting personality has been appreciated by many and resonates with each fan.Read Full Story
Listening to the thumping drumbeat, plucky fiddle and gospel choir-style chorus of Joss Stone's single, "The Answer," it's obvious the soul singer's sound has evolved since she scored her first record deal a decade ago.Read Full Story
The Clutha Trust auction will take place in the next few weeks and give music fans the chance to get their hands on signed merchandise from artists like Blur, Muse, Take That and The Manic Street Preachers.Read Full Story
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Helen Milner
Helen V. Milner (born 1958) is a political scientist from the United States who has written extensively on issues related to international political economy like international trade, the connections between domestic politics and foreign policy, globalization and regionalism, and the relationship between democracy and trade policy.
She graduated with honors in international relations at Stanford University in 1980 and obtained her Ph.D in Political Science at Harvard University in 1986.
Since 2004 she is the B.C. Forbes Professor of Politics and International Affairs at Princeton University and the director of the Niehaus Center for Globalization and Governance at Princeton's Woodrow Wilson School. She was the Department Chair from 2005-2011.
Since 1986 she was a professor at Columbia University and was between 2001 and 2004 James T. Shotwell Professor of International Relations at Columbia University.
For the moment, she is conducting research on issues related to globalization and development, such as the political economy of foreign aid, the digital divide and the global diffusion of the internet, and the relationship between globalization and environmental policy.
Academic awards and honors[edit]
- Fellow, Bellagio Study and Conference Center, Rockefeller Foundation, Bellagio, Italy, summer 2004.
- Fellow, Center for Advanced Study in the Behavioral Sciences, Stanford CA., 2001-2.
- Fellow, American Academy of Arts and Sciences, 2000–present.
- Member, Council on Foreign Relations, 2002–present.
- Research grants, Institute for Social and Economic Policy Research, Columbia University, 1999-2002.
- Social Science Research Council Advanced Research Fellowship in Foreign Policy Studies, 1989-91.
- German Marshall Fund Fellowship, 1989-90 (declined).
- Summer Fellowship, Columbia University Council for Research in the Humanities and Social Sciences, 1987 and 1988.
- Sumner Prize, awarded by Harvard University for the exceptional thesis in international law and peace, June 1986.
- Kennedy Traveling Fellowship, Harvard University, 1985, dissertation research in Paris at the Atlantic Institute for International Relations.
- Research Fellowship, Brookings Institution, Washington, D.C., 1983-1984.
- Teaching Fellowship, Harvard University, 1982-1983.
- Ray Atherton Fellowship in International Relations, Harvard University, 1980-1981 and 1981-1982.
- Phi Beta Kappa, Stanford University, 1979.
- Votes, Vetoes, and the Political Economy of International Trade Agreements. Co-authored with Edward Mansfield. Princeton University Press, 2012.
- Power, Interdependence, and Non-State Actors in World Politics. Coedited with Andrew Moravcsik. Princeton University Press, 2009.
- The International Library of Writings on the New Global Economy. General editor of multi-volume series. London: Edward Elgar, 2002/3.
- Political Science: The State of the Discipline III. Coedited with Ira Katznelson. NY: Norton. 2002.
- Interests, Institutions and Information: Domestic Politics and International Relations. Princeton University Press, 1997.
- The Political Economy of Economic Regionalism. Coedited with Edward Mansfield. NY: Columbia University Press, 1997.
- Internationalization and Domestic Politics. Coedited with Robert Keohane. NY: Cambridge University Press, 1996.
- The Library of International Political Economy. General editor of multi-volume series. London: Edward Elgar, 1993.
- East-West Trade and the Atlantic Alliance. Coedited with David Baldwin. NY: St. Martin's Press, 1990.
- The Political Economy of National Security: An Annotated Bibliography. Coedited with David Baldwin. Boulder, CO: Westview Press, 1989.
- Resisting Protectionism: Global Industries and the Politics of International Trade, Princeton, NJ: Princeton University Press, 1988.
- "Who Supports Global Economic Engagement? The Sources of Preferences in American Foreign Economic Policy" [1] (co-authored with Dustin Tingley) in International Organization, 61, (2011), 1.
- "Regime Type, Veto Points, and Preferential Trading Arrangements" (co-authored with Edward Mansfield) in Stanford Journal of International Law, 46, (2010), 2.
- "The Center Still Holds: The Potential for Liberal Internationalism Survives" (co-authored with Stephen Chaudoin and Dustin Tingley) in International Security, 35, (2010), 1.
- "The Political Economy of U.S. Foreign Aid: American Legislators and the Domestic Politics of Aid" (co-authored with Dustin Tingley) in Economics and Politics, 22, (2010), 2.
- "Introduction: turbulences et stabilité dans les relations transatlantiques" (co-authored with Michel Girard) in Politique Etrangere, 1, (2009).
- "Globalization and Democracy: A Review Essay" (co-authored with Bumba Mukherjee) in Annual Review of Political Science, 12, (2009).
- "The Politics of Foreign Direct Investment into Developing Countries: Increasing FDI through International Trade Agreements?" (co-authored with Tim Büthe) in American Journal of Political Science, 52, (2008), 4.
- "Problems and Progress in the Study of International Organizations" in Journal of Conflict Resolution, 52, (2008), 2.
- "Democracy, Veto Players and the Depth of Regional Integration" (co-authored with Edward Mansfield and Jon Pevehouse) in The World Economy, 31, (2008), 1.
- "International Trade and Environmental Policy in the Postcommunist World" (co-authored with Liliana Andonova and Edward Mansfield) in Comparative Political Studies, 40,(2007), 7.
- "Vetoing Cooperation: The Impact of Veto Players on International Trade Agreements" in British Journal of Political Science, 36, (2006), 4.
- "The Digital Divide: The Role of Domestic Political Institutions in the Spread of the Internet" in Comparative Political Studies, 39, (2006), x.
- "Globalization, Development, and International Institutions: Normative and Positive Perspectives" in Perspectives on Politics, 3, (2005),4.
- "Why the Move to Free Trade? Democracy and Trade Policy in the Developing Countries" (co-authored with Keiko Kubota) in International Organization, x, 2005, x.
- "Partisanship, Trade Policy and Globalization: Is there a Left-Right Party Divide on Trade Policy?" (co-authored with Benjamin Judkins) in International Studies Quarterly, 48, 2004,1, pp. 95–119.
- "Why Democracies Cooperate More: Electoral Control and International Trade Agreements" (co-authored with Edward Mansfield and B. Peter Rosendorff in International Organization,56, (2002), 3, pp. 477–513.
- "Replication, Realism, and Robustness: Analyzing Political Regimes and International Trade" (co-authored with Edward Mansfield and B. Peter Rosendorff) in American Political Science Review, 96, (2002), 1, pp. 167–169.
- "The Optimal Design of International Institutions: Why Escape Clauses are Essential." (co-authored with B. Peter Rosendorff) in International Organization, 55, (2001), 4, pp. 829–857.
- "Product Standards and International and Regional Competition." (co-authored with Marc Austin) in Journal of European Public Policy, 8, (2001), 3, pp. 411–431.
- "Free to Trade? Democracies, Autocracies, and International Trade Negotiations." (co-authored with Edward Mansfield and B. Peter Rosendorff) in American Political Science Review, 94, (2000), 2, pp. 305–322.
- "The Political Economy of Regionalism" (co-authored with Edward Mansfield) in International Organization, 53, (1999), 3, pp. 589–627.
- "The Political Economy of International Trade." in Annual Review of Politics, 2, (1999), x, pp. 91–114.
- "Rationalizing Politics: The Emerging Synthesis of International, American and Comparative Politics" in International Organization, 52, (1998), 4, pp. 759–786.
- "International Political Economy: Beyond American Hegemony." in Foreign Policy, x, (1998), 110, pp. 112–124. [2]
- "Democratic Politics and International Trade Negotiations: Elections and Divided Government as Constraints on Trade Liberalization" (co-authored with B. Peter Rosendorff) in Journal of Conflict Resolution, 41, (1997), 1, pp. 117–146.
- "Trade Negotiations, Information and Domestic Politics." (coauthored with B. Peter Rosendorff) in Economics and Politics, 8, (1996), 2, pp. 145–189.
- "Regional Economic Cooperation, Global Markets and Domestic Politics: A Comparison of NAFTA and the Maastricht Treaty" in Journal of European Public Policy, 2, (1995), 3, pp. 337–360.
- "American Debt and World Power" in International Journal, 43, (1993), 3, pp. 527–560.
- "International Theories of Cooperation among Nations: A Review Essay," in World Politics, 44, (1992), 3, pp. 466–496.
- "The Assumption of Anarchy in International Relations: A Critique," in Review of International Studies, 17, (1991), 1, pp. 67–85.
- "An Alternative to Free Trade or Protectionism: Why Corporations Seek Strategic Trade Policy" (co-authored with David Yoffie) in California Management Review, 31, (1989), 4, pp. 111–131.
- "Domestic and International Sources of Economic Cooperation: Oil Politics in the 1940s and 1970s" in International Spectator, 24, (1989), 3/4, pp. 141–151.
- "Between Free Trade and Protectionism: Strategic Trade Policy and a Theory of Corporate Preferences" (co-authored with David Yoffie) in International Organization, 43, (1989), 2, pp. 239–272.
- "Trading Places: Industries for Free Trade" in World Politics, 40, (1988), 3, pp. 350–376.
- "Lost Hegemony?" (co-authored with Jack Snyder) in International Organization, 42, (1988), 4, pp. 749–50.
- "Resisting the Protectionist Temptation: Industry and the Making of Trade Policy in France and the US in the 1970s" in International Organization, 41, (1987), 4, pp. 639–665.
External links[edit]
(Works by or about Helen Milner in libraries (WorldCat catalog)


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Are you Stuart Cobb?Claim your profile
Publications (56)201.7 Total impact
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Article: Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors[Show abstract] [Hide abstract]
ABSTRACT: This study assessed the anticonvulsant and seizure generation effects of carbamazepine (CBZ), oxcarbazepine (OXC) and eslicarbazepine (S-Lic) in wild-type mice. Electrophysiological recordings were made to discriminate potential cellular and synaptic mechanisms underlying anti- and pro-epileptic actions. The anticonvulsant and pro-convulsant effects were evaluated in the MES, the 6-Hz and the Irwin tests. Whole-cell patch-clamp recordings were used to investigate the effects on fast excitatory and inhibitory synaptic transmission in hippocampal area CA1. The safety window for CBZ, OXC and eslicarbazepine (ED50 value against the MES test and the dose that produces grade 5 convulsions in all mice), was 6.3, 6.0 and 12.5, respectively. At high concentrations the three drugs reduced synaptic transmission. CBZ and OXC enhanced excitatory postsynaptic currents (EPSCs) at low, therapeutically-relevant concentrations. These effects were associated with no change in inhibitory postsynaptic currents (IPSCs) resulting in altered balance between excitation and inhibition. S-Lic had no effect on EPSC or IPSC amplitudes over the same concentration range. The CBZ mediated enhancement of EPSCs was blocked by DPCPX, a selective antagonist, and occluded by CCPA, a selective agonist of the adenosine A1 receptor. Furthermore, reduction of endogenous adenosine by application of the enzyme adenosine deaminase also abolished the CBZ- and OXC-induced increase of EPSCs, indicating that the two drugs act as antagonists at native adenosine receptors. In conclusion, CBZ and OXC possess pro-epileptic actions at clinically-relevant concentrations through the enhancement of excitatory synaptic transmission. S-Lic by comparison has no such effect on synaptic transmission, explaining its lack of seizure exacerbation.Neuropharmacology 02/2015; 93. DOI:10.1016/j.neuropharm.2015.01.019 · 4.82 Impact Factor
Article: Gait Analysis in a Mecp2 Knockout Mouse Model of Rett Syndrome Reveals Early-Onset and Progressive Motor Deficits[Show abstract] [Hide abstract]
ABSTRACT: Rett syndrome (RTT) is a genetic disorder characterized by a range of features including cognitive impairment, gait abnormalities and a reduction in purposeful hand skills. Mice harbouring knockout mutations in the Mecp2 gene display many RTT-like characteristics and are central to efforts to find novel therapies for the disorder. As hand stereotypies and gait abnormalities constitute major diagnostic criteria in RTT, it is clear that motor and gait-related phenotypes will be of importance in assessing preclinical therapeutic outcomes. We therefore aimed to assess gait properties over the prodromal phase in a functional knockout mouse model of RTT. In male Mecp2 knockout mice, we observed alterations in stride, coordination and balance parameters at 4 weeks of age, before the onset of other overt phenotypic changes as revealed by observational scoring. These data suggest that gait measures may be used as a robust and early marker of MeCP2-dysfunction in future preclinical therapeutic studies.PLoS ONE 11/2014; 9(11):e112889. DOI:10.1371/journal.pone.0112889 · 3.53 Impact Factor
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ABSTRACT: Rett syndrome (RTT) is an X-linked genetic disorder and a major cause of intellectual disability in girls. Mutations in the methyl-CpG binding protein 2 (MECP2) gene are the primary cause of the disorder. Despite the dominant neurological phenotypes, MECP2 is expressed ubiquitously throughout the body and a number of peripheral phenotypes such as scoliosis, reduced bone mineral density and skeletal fractures are also common and important clinical features of the disorder. In order to explore whether MeCP2 protein deficiency results in altered structural and functional properties of bone and to test the potential reversibility of any defects, we have conducted a series of histological, imaging and biomechanical tests of bone in a functional knockout mouse model of RTT. Both hemizygous Mecp2(stop/y) male mice in which Mecp2 is silenced in all cells and female Mecp2(stop/+) mice in which Mecp2 is silenced in similar to 50% of cells as a consequence of random X-chromosome inactivation, revealed significant reductions in cortical bone stiffness, microhardness and tensile modulus. Microstructural analysis also revealed alterations in both cortical and cancellous femoral bone between wild-type and MeCP2-deficient mice. Furthermore, unsilencing of Mecp2 in adult mice cre-mediated stop cassette deletion resulted in a restoration of biomechanical properties (stiffness, microhardness) towards wild-type levels. These results show that MeCP2-deficiency results in overt, but potentially reversible, alterations in the biomechanical integrity of bone and highlights the importance of targeting skeletal phenotypes in considering the development of pharmacological and gene-based therapies. (C) 2014 The Authors. Published by Elsevier Inc.Bone 10/2014; 71. DOI:10.1016/j.bone.2014.10.008 · 4.46 Impact Factor
Article: A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus[Show abstract] [Hide abstract]
ABSTRACT: Cellular activity in the CA1 area of the hippocampus waxes and wanes at theta frequency (4-8Hz) during exploratory behaviour of rats. Perisomatic inhibition onto pyramidal cells tends to be strongest out of phase with pyramidal cell activity, whereas dendritic inhibition is strongest in phase with pyramidal cell activity. Synaptic plasticity also varies across the theta cycle, from strong long-term potentiation (LTP) to long-term-depression (LTD), putatively corresponding to encoding and retrieval phases for information patterns encoded by pyramidal cell activity (Hasselmo et al, 2002a). The mechanisms underpinning the phasic changes in plasticity are not clear, but it is likely that inhibition plays a role by affecting levels of electrical activity and calcium concentration at synapses. We explore the properties of synaptic plasticity during theta at Schaffer collateral synapses on CA1 pyramidal neurons and the influence of spatially and temporally targeted inhibition using a detailed multicompartmental model of the CA1 pyramidal neuron microcircuit and a phenomenological model of synaptic plasticity. The results suggest CA3-CA1 synapses are potentiated on one phase of theta due to high calcium levels provided by paired weak CA3 and layer III entorhinal cortex (EC) inputs even when somatic spiking is inhibited by perisomatic interneuron activity. Weak CA3 inputs alone induce lower calcium transients and result in depression of the CA3-CA1 synapses. These synapses are depressed if activated in phase with dendritic inhibition as strong CA3 inputs alone are not able to cause high calcium in this theta phase even though the CA1 pyramidal neuron shows somatic spiking. Dendritic inhibition acts as a switch that prevents LTP and promotes LTD during the retrieval phases of the theta rhythm in CA1 pyramidal cell. This may be important for not overly reinforcing recalled memories and in forgetting no longer relevant memories. © 2014 Wiley Periodicals, Inc.Hippocampus 09/2014; 25(2). DOI:10.1002/hipo.22365 · 4.30 Impact Factor
Article: Spine Head Calcium as a Measure of Summed Postsynaptic Activity for Driving Synaptic Plasticity[Show abstract] [Hide abstract]
ABSTRACT: We use a computational model of a hippocampal CA1 pyramidal cell to demonstrate that spine head calcium provides an instantaneous readout at each synapse of the postsynaptic weighted sum of all presynaptic activity impinging on the cell. The form of the readout is equivalent to the functions of weighted, summed inputs used in neural network learning rules. Within a dendritic layer, peak spine head calcium levels are either a linear or sigmoidal function of the number of coactive synapses, with nonlinearity depending on the ability of voltage spread in the dendrites to reach calcium spike threshold. This is strongly controlled by the potassium A-type current, with calcium spikes and the consequent sigmoidal increase in peak spine head calcium present only when the A-channel density is low. Other membrane characteristics influence the gain of the relationship between peak calcium and the number of active synapses. In particular, increasing spine neck resistance increases the gain due to increased voltage responses to synaptic input in spine heads. Colocation of stimulated synapses on a single dendritic branch also increases the gain of the response. Input pathways cooperate: CA3 inputs to the proximal apical dendrites can strongly amplify peak calcium levels due to weak EC input to the distal dendrites, but not so strongly vice versa. CA3 inputs to the basal dendrites can boost calcium levels in the proximal apical dendrites, but the relative electrical compactness of the basal dendrites results in the reverse effect being less significant. These results give pointers as to how to better describe the contributions of pre- and postsynaptic activity in the learning "rules" that apply in these cells. The calcium signal is closer in form to the activity measures used in traditional neural network learning rules than to the spike times used in spike-timing-dependent plasticity.Neural Computation 07/2014; 26(10):1-29. DOI:10.1162/NECO_a_00640 · 1.69 Impact Factor
Article: Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice[Show abstract] [Hide abstract]
ABSTRACT: Numerous experimental models have been developed to reiterate endophenotypes of Rett syndrome, a neurodevelopmental disorder with a multitude of motor, cognitive and vegetative symptoms. Here, female Mecp2(Stop) mice (Guy et al., 2007)[1] were characterised at mild symptomatic conditions in tests for anxiety (open field, elevated plus maze) and home cage observation systems for food intake, locomotor activity and circadian rhythms. Aged 8-9 months, Mecp2(Stop) mice presented with heightened body weight, lower overall activity in the open field, but no anxiety phenotype. Although home cage activity scans conducted in two different observation systems, PhenoMaster and PhenoTyper, confirmed normal circadian activity, they revealed severely compromised habituation to a novel environment in all parameters registered including those derived from a non-linear decay model such as initial exploration maximum, decay half-life of activity and span, as well as plateau. Furthermore, overall activity was significantly reduced in nocturnal periods due to reductions in both fast ambulatory movements, but also a slow lingering. In contrast, light-period activity profiles during which the amount of sleep was highest remained normal in Mecp2(Stop) mice. These data confirm the slow and progressive development of Rett-like symptoms in female Mecp2(Stop) mice resulting in a prominent reduction of overall locomotor activity, while circadian rhythms are maintained. Alterations in the time-course of habituation may indicate deficiencies in cognitive processing.Behavioural brain research 05/2013; 250. DOI:10.1016/j.bbr.2013.04.041 · 3.39 Impact Factor
Article: Neurodevelopmental disorders.Neuropharmacology 02/2013; DOI:10.1016/j.neuropharm.2013.02.001 · 4.82 Impact Factor
Article: Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome[Show abstract] [Hide abstract]
ABSTRACT: Rett syndrome (RTT) is a disorder with a pronounced neurological phenotype and is caused mainly by mutations in the X-linked gene MECP2. A common feature of RTT is an abnormal EEG and a propensity for seizures. In the current study we aimed to assess brain network excitability and seizure propensity in a mouse model of RTT. Mice in which Mecp2 expression was silenced (Mecp2(stop/y)) showed a higher seizure score (mean = 6 ± 0.8 compared to 4 ± 0.2 in wild-type, WT) and more rapid seizure onset (median onset = 10 mins in Mecp2(stop/y) and 32 mins in WT) when challenged with the convulsant drug kainic acid (25mg/Kg). Hippocampal slices from Mecp2(stop/y) brain displayed no spontaneous field potential activities under control conditions but showed higher power gamma frequency field potential oscillations compared to WT in response to kainic acid (400 nM) in vitro. Brain slices challenged with the GABA(A) receptor antagonist bicuculline (0.1-10μM) and the potassium channel blocker 4-aminopyridine (1-50μM) also revealed differences between genotypes with hippocampal circuits from Mecp2(stop/y) mouse slices showing enhanced epileptiform burst duration and frequency. In contrast to these network level findings, single cell analysis of pyramidal cells by whole-cell patch clamp recording revealed no detectable differences in synaptic or biophysical properties between MeCP2-containing and MeCP2-deficient neurons. These data support the proposal that loss of MeCP2 alters network level excitability in the brain to promote epileptogenesis.Neuroscience 12/2012; 231. DOI:10.1016/j.neuroscience.2012.11.058 · 3.33 Impact Factor
Article: Improved Survival and Reduced Phenotypic Severity Following AAV9/MECP2 Gene Transfer to Neonatal and Juvenile Male Mecp2 Knockout Mice.[Show abstract] [Hide abstract]
ABSTRACT: Typical Rett syndrome (RTT) is a pediatric disorder caused by loss-of-function mutations in the methyl-CpG binding protein 2 (MECP2) gene. The demonstrated reversibility of RTT-like phenotypes in mice suggests that MECP2 gene replacement is a potential therapeutic option in patients. We report improvements in survival and phenotypic severity in Mecp2-null male mice after neonatal intracranial delivery of a single-stranded (ss) AAV9/chicken β-actin (CBA)-MECP2 vector. Median survival was 16.6 weeks for MECP2-treated versus 9.3 weeks for green fluorescent protein (GFP)-treated mice. ssAAV9/CBA-MECP2-treated mice also showed significant improvement in the phenotype severity score, in locomotor function, and in exploratory activity, as well as a normalization of neuronal nuclear volume in transduced cells. Wild-type (WT) mice receiving neonatal injections of the same ssAAV9/CBA-MECP2 vector did not show any significant deficits, suggesting a tolerance for modest MeCP2 overexpression. To test a MECP2 gene replacement approach in a manner more relevant for human translation, a self-complementary (sc) adeno-associated virus (AAV) vector designed to drive MeCP2 expression from a fragment of the Mecp2 promoter was injected intravenously (IV) into juvenile (4-5 weeks old) Mecp2-null mice. While the brain transduction efficiency in juvenile mice was low (~2-4% of neurons), modest improvements in survival were still observed. These results support the concept of MECP2 gene therapy for RTT.Molecular Therapy (2012); doi:10.1038/mt.2012.200.Molecular Therapy 09/2012; DOI:10.1038/mt.2012.200 · 6.43 Impact Factor
Article: A computational study of the influence of synaptic cooperativity on synaptic plasticity in a hippocampal CA1 pyramidal cellBMC Neuroscience 07/2012; 13(1). DOI:10.1186/1471-2202-13-S1-P164 · 2.85 Impact Factor
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ABSTRACT: Rett syndrome is a neurological disorder caused by mutation of the X-linked MECP2 gene. Mice lacking functional Mecp2 display a spectrum of Rett syndrome-like signs, including disturbances in motor function and abnormal patterns of breathing, accompanied by structural defects in central motor areas and the brainstem. Although routinely classified as a neurodevelopmental disorder, many aspects of the mouse phenotype can be effectively reversed by activation of a quiescent Mecp2 gene in adults. This suggests that absence of Mecp2 during brain development does not irreversibly compromise brain function. It is conceivable, however, that deep-seated neurological defects persist in mice rescued by late activation of Mecp2. To test this possibility, we have quantitatively analysed structural and functional plasticity of the rescued adult male mouse brain. Activation of Mecp2 in ∼70% of neurons reversed many morphological defects in the motor cortex, including neuronal size and dendritic complexity. Restoration of Mecp2 expression was also accompanied by a significant improvement in respiratory and sensory-motor functions, including breathing pattern, grip strength, balance beam and rotarod performance. Our findings sustain the view that MeCP2 does not play a pivotal role in brain development, but may instead be required to maintain full neurological function once development is complete.Brain 04/2012; 135(Pt 9):2699-710. DOI:10.1093/brain/aws096 · 10.23 Impact Factor
Article: Rett Syndrome: From Bed to Bench[Show abstract] [Hide abstract]
ABSTRACT: Rett syndrome (RTT), a neurodevelopmental condition characterized by delayed-onset loss of spoken language and the development of distinctive hand stereotypies, affects approximately 1 in 10,000 live female births. Clinical diagnosis has been based on symptoms such as loss of acquired purposeful hand skills, autistic behaviors, motor dysfunctions, seizure disorders, and gait abnormalities. RTT is a genetic disease and is caused almost exclusively by mutations in the X-linked gene, MECP2, to produce a phenotype that is thought to be primarily of neurological origin. Clinical reports show RTT patients to have a smaller brain volume, especially in the cerebral hemispheres, and alterations in various neurotransmitter systems, including acetylcholine, dopamine, serotonin, glutamate, substance P, and various trophic factors. Because of its monogenetic characteristic, disruption of Mecp2 is readily recapitulated in mice to produce a prominent RTT-like phenotype and provide an excellent platform for understanding the pathogenesis of RTT. As shown in human studies, Mecp2 mutants also display subtle alterations in neuronal morphology, including smaller cortical neurons with a higher-packing density and reduced dendritic complexity. Neurophysiological studies in Mecp2-mutant mice consistently report alterations in synaptic function, notably, defects in synaptic plasticity. These data suggest that RTT might be regarded as a synaptopathy (disease of the synapse) and thus potentially amenable to rational therapeutic intervention.Pediatrics & Neonatology 12/2011; 52(6):309-16. DOI:10.1016/j.pedneo.2011.08.002 · 0.88 Impact Factor
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ABSTRACT: Caspase 3 activation has been linked to the acute neurotoxic effects of central nervous system damage, as in traumatic brain injury or cerebral ischaemia, and also to the early events leading to long-term neurodegeneration, as in Alzheimer's disease. However, the precise mechanisms activating caspase 3 in neuronal injury are unclear. RhoB is a member of the Rho GTPase family that is dramatically induced by cerebral ischaemia or neurotrauma, both in preclinical models and clinically. In the current study, we tested the hypothesis that RhoB might directly modulate caspase 3 activity and apoptotic or necrotic responses in neurons. Over-expression of RhoB in the NG108-15 neuronal cell line or in cultured corticohippocampal neurons elevated caspase 3 activity without inducing overt toxicity. Cultured corticohippocampal neurons from RhoB knockout mice did not show any differences in sensitivity to a necrotic stimulus - acute calcium ionophore exposure - compared with neurons from wild-type mice. However, corticohippocampal neurons lacking RhoB exhibited a reduction in the degree of DNA fragmentation and caspase 3 activation induced by the apoptotic agent staurosporine, in parallel with increased neuronal survival. Staurosporine induction of caspase 9 activity was also suppressed. RhoB knockout mice showed reduced basal levels of caspase 3 activity in the adult brain. These data directly implicate neuronal RhoB in caspase 3 activation and the initial stages of programmed cell death, and suggest that RhoB may represent an attractive target for therapeutic intervention in conditions involving elevated caspase 3 activity in the central nervous system.European Journal of Neuroscience 11/2011; 34(11):1737-46. DOI:10.1111/j.1460-9568.2011.07891.x · 3.67 Impact Factor
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ABSTRACT: Mutations in the X-linked gene MECP2 (methyl CpG-binding protein 2) are the primary cause of the neurodevelopmental disorder RTT (Rett syndrome), and are also implicated in other neurological conditions. The expression product of this gene, MeCP2, is a widely expressed nuclear protein, especially abundant in mature neurons of the CNS (central nervous system). The major recognized consequences of MECP2 mutation occur in the CNS, but there is growing awareness of peripheral effects contributing to the full RTT phenotype. MeCP2 is classically considered to act as a DNA methylation-dependent transcriptional repressor, but may have additional roles in regulating gene expression and chromatin structure. Knocking out Mecp2 function in mice recapitulates many of the overt neurological features seen in RTT patients, and the characteristic postnatally delayed onset of symptoms is accompanied by aberrant neuronal morphology and deficits in synaptic physiology. Evidence that reactivation of endogenous Mecp2 in mutant mice, even at adult stages, can reverse aspects of RTT-like pathology and result in apparently functionally mature neurons has provided renewed hope for patients, but has also provoked discussion about traditional boundaries between neurodevelopmental disorders and those involving dysfunction at later stages. In the present paper we review the neurobiology of MeCP2 and consider the various genetic (including gene therapy), pharmacological and environmental interventions that have been, and could be, developed to attempt phenotypic rescue in RTT. Such approaches are already providing valuable insights into the potential tractability of RTT and related conditions, and are useful pointers for the development of future therapeutic strategies.Biochemical Journal 10/2011; 439(1):1-14. DOI:10.1042/BJ20110648 · 4.78 Impact Factor
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ABSTRACT: Synaptic plasticity is the ability of synaptic connections between neurons to be strengthened or weakened; a process that is central to the information processing within the brain and which plays a particularly important role in enabling higher cognitive processes [1,2]. Its role in disease is becoming increasingly clear across a wide spectrum of CNS disorders. Thus, for example, dysfunctional synaptic plasticity has been reported in neurodegenerative disorders such as Alzheimer's Disease (AD) as well as in schizophrenia and in a range of disorders associated with learning disabilities [3]. Moreover, maladaptive plasticity processes in response to specific external challenges are believed to underlie disorders such as addiction and post-traumatic stress disorder (PTSD). The molecular basis of normal and disease plasticity is rapidly being unravelled such that synaptic plasticity now provides a unique platform from which to launch the hunt for highly innovative drugs to treat CNS disease by either, firstly, rectifying identifiable abnormalities in these processes, or secondly, utilizing these processes as a vehicle to rectify, or bypass, other mechanisms underlying disease. In this respect, recent advances have been made in studying synaptic plasticity in humans at the molecular through to clinical level and these approaches now provide a real opportunity to test synaptic plasticity as a treatment paradigm for a wide variety of CNS disorders.Current Opinion in Pharmacology 07/2011; 11(5):540-8. DOI:10.1016/j.coph.2011.06.008 · 4.23 Impact Factor
Article: Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2.[Show abstract] [Hide abstract]
ABSTRACT: Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS under normal physiological conditions. However, its potential role in modulating neuronal excitability and synaptic transmission remains to be determined. Here, we have investigated whether PAR2 activation modulates synaptic activity in the hippocampus. PAR2 activation and its effect on the hippocampus were examined in rat primary cultures and acute slices using whole cell patch clamp and standard extracellular recordings, respectively. PAR2 activation leads to a depolarization of hippocampal neurones and a paradoxical reduction in the occurrence of synaptically driven spontaneous action potentials (APs). PAR2-induced neuronal depolarization was abolished following either the inhibition of astrocytic function or antagonism of ionotropic glutamate receptors whilst the PAR2-induced decrease in AP frequency was also reduced when astrocytic function was inhibited. Furthermore, when examined in acute hippocampal slices, PAR2 activation induced a profound long-term depression of synaptic transmission that was dependent on NMDA receptor activation and was sensitive to disruption of astrocytic function. These novel findings show that PAR2 activation indirectly inhibits hippocampal synaptic activity and indicate that these receptors may play an active role in modulating normal physiological CNS function, in addition to their role in pathophysiological disorders.British Journal of Pharmacology 03/2011; 163(5):984-94. DOI:10.1111/j.1476-5381.2011.01293.x · 4.99 Impact Factor
Article: Synaptic plasticity deficits in an experimental model of rett syndrome: long-term potentiation saturation and its pharmacological reversal.[Show abstract] [Hide abstract]
ABSTRACT: Rett syndrome (RTT), a disorder caused almost exclusively by mutations in the X-linked gene, MECP2, has a phenotype thought to be primarily of neurological origin. Disruption of Mecp2 in mice results in a prominent RTT-like phenotype. One of the consequences of MeCP2 absence in the brain is altered functional and structural plasticity. We aimed to characterize synaptic effects related to plasticity in the hippocampus further and establish whether plasticity defects are amenable to pharmacological reversal. Using male mice in which Mecp2 expression was prevented by a stop cassette, we assessed synaptic plasticity in area CA1 at different phenotypic stages, scoring the mice weekly for overt RTT-like signs. Strongly symptomatic Mecp2(stop/y) mice displayed reduced long-term potentiation (LTP, 40.2±1.6% of wild-type), post-tetanic potentiation (PTP, 45±18.8% of wild-type) and paired-pulse facilitation (PPF, 78±0.1% of wild type) (all P<0.05), the impairment increasing with symptom severity score. These plasticity impairments were absent in presymptomatic mice. Repeated high frequency stimulation revealed pronounced LTP saturation in symptomatic Mecp2(stop/y) mice, suggesting an LTP 'ceiling' effect. Bath application of the weak NMDA receptor blocker memantine (1 μM) resulted in partial restoration of a short-term plasticity component. These data support that idea that progressive functional synaptic impairment is a key feature in the RTT brain and demonstrate the potential for the pharmacological restoration of plasticity function.Neuroscience 02/2011; 180:314-21. DOI:10.1016/j.neuroscience.2011.01.061 · 3.33 Impact Factor
Conference Paper: Bio-inspired models of memory capacity, recall performance and theta phase precession[Show abstract] [Hide abstract]
ABSTRACT: The hippocampus plays an important role in the encoding and retrieval of spatial and non-spatial memories. Much is known about the anatomical, physiological and molecular characteristics as well as the connectivity and synaptic properties of various cell types in the hippocampal circuits [1], but how these detailed properties of individual neurons give rise to the encoding and retrieval of memories remains unclear. Computational models play an instrumental role in providing clues on how these processes may take place. Here, we present three computational models of the region CA1 of the hippocampus at various levels of detail. Issues such as retrieval of memories as a function of cue loading, presentation frequency and learning paradigm, memory capacity, recall performance, and theta phase precession in the presence of dopamine neuromodulation and various types of inhibitory interneurons are addressed. The models lead to a number of experimentally testable predictions that may lead to a better understanding of the biophysical computations in the hippocampus.IJCNN 2011; 01/2011
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ABSTRACT: Mutations in the X-linked MECP2 gene are the primary cause of the severe autism spectrum disorder RTT (Rett syndrome). Deletion of Mecp2 in mice recapitulates many of the overt neurological features seen in humans, and the delayed onset of symptoms is accompanied by deficits in neuronal morphology and synaptic physiology. Recent evidence suggests that reactivation of endogenous Mecp2 in young and adult mice can reverse aspects of RTT-like pathology. In the current perspective, we discuss these findings as well as other genetic, pharmacological and environmental interventions that attempt phenotypic rescue in RTT. We believe these studies provide valuable insights into the tractability of RTT and related conditions and are useful pointers for the development of future therapeutic strategies.Biochemical Society Transactions 04/2010; 38(2):498-506. DOI:10.1042/BST0380498 · 3.24 Impact Factor
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ABSTRACT: Actin-rich dendritic spines are the locus of excitatory synaptic transmission and plastic events such as long-term potentiation (LTP). Morphological plasticity of spines accompanies activity-dependent changes in synaptic strength. Several Rho GTPase family members are implicated in regulating neuronal and, in particular, spine structure via actin and the actin-binding protein cofilin. However, despite expression in hippocampus and cortex, its ability to modulate actin-regulatory proteins, and its induction during aging, RhoB has been relatively neglected. We previously demonstrated that LTP is associated with specific RhoB activation. Here, we further examined its role in synaptic function using mice with genetic deletion of the RhoB GTPase (RhoB(-/-) mice). Normal basal synaptic transmission accompanied reduced paired-pulse facilitation and post-tetanic potentiation in the hippocampus of RhoB(-/-) mice. Early phase LTP was significantly reduced in RhoB(-/-) animals, whereas the later phase was unaffected. In wild-type mice (RhoB(+/+)), Western blot analysis of potentiated hippocampus showed significant increases in phosphorylated cofilin relative to nonpotentiated slices, which were dramatically impaired in RhoB(-/-) slices. There was also a deficit in phosphorylated Lim kinase levels in the hippocampus from RhoB(-/-) mice. Morphological analysis suggested that lack of RhoB resulted in increased dendritic branching and decreased spine number. Furthermore, an increase in the proportion of stubby relative to thin spines was observed. Moreover, spines demonstrated increased length along with increased head and neck widths. These data implicate RhoB in cofilin regulation and dendritic and spine morphology, highlighting its importance in synaptic plasticity at a structural and functional level.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 03/2010; 30(9):3508-17. DOI:10.1523/JNEUROSCI.5386-09.2010 · 6.75 Impact Factor
Top Journals
University of Glasgow
Glasgow, Scotland, United Kingdom
- Institute of Neuroscience and Psychology
The University of EdinburghEdinburgh, Scotland, United Kingdom
University of Bristol
Bristol, ENG, United Kingdom
- Centre for Synaptic Plasticity


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THE MATCH: Real Madrid-Dortmund Champions League second leg semi-finals (with Sid Lowe)
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does ryan kennelly use steroids - pictures
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Don't Stop on Six // It Will Happen
The finish line. The goal. What are you working toward? Obstacles and trials will come and go, but one thing can always remain constant on your journey.
Keep your eyes on the prize because good things happen when you Don't Stop.
Jesus Is Building His Church!
Discussion in 'Sermons' started by abigya, Sep 30, 2009.


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4th of July Celebration AT KRAVE LOUNGE THIS SATURDAY
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Today (THU) is Tax Freedom Day – the day that Americans will have earned enough money to pay this year's tax obligations at the federal, state, and local levels. Both higher federal taxes and rebounding incomes contribute to this year's date, which is five days later than in 2012. But if you factor in the federal budget deficit, in order to pay for all spending in the current year, the government would need to raise an additional $833-billion in taxes, pushing Tax Freedom Day to May 9th. Historically, the date for Tax Freedom Day has fluctuated significantly. The latest-ever nationwide Tax Freedom Day was May 1st, 2000 – meaning that Americans paid one-third of their total income in taxes that year. A century earlier, in 1900, Americans paid only 5.9% of their income in taxes, meaning Tax Freedom Day came on January 22nd.
American Tax Freedom Day Today


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Two early tracks from Toronto's The Weeknd have hit the internet. "Superhero" and "Cure" were recorded in 2009 and are much poppier than the singer's usual dark, twinkling output. Listen to both over at You Heard That New.
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Live updates
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Pictures: Princess Anne visits Dumfries
Awaiting the Princess Royal
A pipe band entertains the crowds as they prepare to welcome the Princess Royal to Dumfries.
Princess Anne is visiting the town to unveil a sculpture of Scotland's national poet Robert Burns.
Burns sculpture features his most famous poems
A sculpture of the famous Scots poet Robert Burns is being unveiled by Princess Anne in Dumfries.
The sculpture, which features some of Burns' most famous poems, including Tam O' Shanter and "To a mouse", is commemorating the 60th Anniversary of the Coronation of Queen Elizabeth II.
Local artist David Gulland designed the sculpture, which was then created from Dumfries sandstone by stonemason David Little.
The centre piece focuses on the Dumfriesshire landscape, with a gently flowing stream and a number of sheep- referring to Burns' well known song "Ca the yowes to the knowes".
Princess Anne visits Dumfries
The Princess Royal is visiting Dumfries today to unveil a sculpture of poet Robert Burns.
"Robert Burns' Rock" was gifted by The People's Project to the people of Dumfries and Galloway to mark the 60th Anniversary of the Coronation of Queen Elizabeth II.
The sculpture, which sits opposite the statue of Burns' wife Jean Armour near to St. Michael Street, has been created from Dumfries sandstone by David Little.
Princess Anne comes to Melrose
Her Royal Highness The Princess Royal will represent the Queen at a Thanksgiving Service to mark Her Majesty's Diamond Jubilee at Melrose Parish church on Tuesday 11 September. Afterwards she will attend a reception hosted by Scottish Borders Council.
Princess Anne will meet with representatives of local voluntary organisations and present British Empire Medals to two new Lord-Lieutenants who represent the crown in every county in the UK.


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The Message audio Bible is now available on Bible Gateway! Click to learn more.
A central feature of Jesus Christ's ministry was his declaration that believers'sins were forgiven through their faith in him.
Mt 1:20-21; Jn 1:29
Lk 23:33-34 See also Jn 8:3-11
Mt 9:1-8 pp Mk 2:1-12 pp Lk 5:17-26 Jesus Christ's authority to forgive is authenticated by his healing of the paralytic.
Mk 2:5-7 pp Mt 9:2-3 pp Lk 5:20-21
Jn 20:21-23 See also Ac 2:38; Ac 13:38; Ac 26:15-18


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The C-TeamThe C-Team (1983) Season 1 Episode 1A - 5112-8315- Alvin and the Chipmunks Cartoon Episode Guide by Dave Koch
This page has been viewed 22 times this month, and 841 times total.
- Alvin and the Chipmunks Cartoon Episode GuideEpisode GuideTelevisionSeriesCartoon
- Traditional Animation
- Ruby-Spears Productions
- Animation Studio: Wang Film Productions
- Distributed by: Warner Bros. Television, Bagdasarian Productions
- Cartoon Characters: Alvin, Simon, Theodore, David Seville, Mrs. Miller, Mr. T.
- Voice Actors: Ross Bagdasarian, Jr., Janice Karman, Dodie Goodman, Mr. T, Booker Bradshaw, Johnny Brown, Arthur Burghardt, Ruth Buzzi, Henry Corden; Full Voice Cast ...
- Directed By Charles Nichols, Rudy Larriva, John Kimball.
- Produced By Janice Karman, Ross Bagdasarian, Joe Ruby, Ken Spears, Larry Huber.
- Written By Michael Maurer, Matt Uitz, Cliff Ruby, Elana Lesser.
- Music: Chris Caswell, Paul DeKorte.
- First Aired on September 17, 1983.
- Originally Aired on NBC-TV (USA).
- Running Time: 11 minutes.
- Season: 1
- Color
Cartoon Summary:
The Chipmunks enlist the aid of Mr. T to form their own "C Team" in order to recover a stolen heirloom from a trio of bullies.
Cartoon Production Information:
Ross Bagdasarian created an unlikely smash when he changed his name to David Seville, multitracked his own voice, and recorded the novelty single "The Chipmunk Song." That led to 1961's The Alvin... (more)
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connecting comp on receiver
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Join Date: Jul 2005
Posts: 379
Re: connecting comp on receiver
Originally Posted by
Hi and thanks for replys. I have all hoked up and it all works but...i would like when playing a game that the receiver would do decoding (now it says pcm 5.1) is that possible? I know how to set it all up when watching movies so that the receiver would do decoding but i dont know for games. And i have a marantz 5004 and with the blurays and hd sound i must set it so that the computer will do decoding or i cant use audyssey with it (it is the limitation of last years marantz receivers) if receiver does hd decoding...but i am not sure if the sound send to
my receiver is hd at all as it only says pcm 5.1 but when receiver does it says dd hd master audio or dts hd...but no audyssey. And i have another minor problem...i can hear when lets say in game i change resolution in the center channel it pops (not very loud but audible and only in center channel) what could that be...a bad hdmi cable? My gear is marantz sr 5004 and monitor audio bx speakers and mirage s12 sub. When i had dvd connected to my receiver i have never heard any pops so that is very odd.
I like a song hotel california too
but i have never heard it in 5.1 96k i would say it must sound awesome and specially the woofer as the drums are freaking awesome in that song
. I only have metallica in dts 5.1 the concert in France i think that was a few years ago if i remember correctly and it sounds good too.
And another thing is it ok that my signal send from computer to receiver is set @ 24 bits 96k or i should set it @ 16 bits 44k as it is by default?
If the receiver is saying pcm 5.1 in games you are good to go and the receiver is doing all the work. Pcm means zero compression. You are hearing the sounds in their best possible form. I leave windows settings at 24 bit 48000. The music player I used switches that depending on the source. IF you are not using wasapi look in to it now. Foobar is a great player with the wasapi plugin. Then the music will switch your receiver in to what ever mode the source is encoded in if you set it up that way. Let movies do what ever they want (always dts over dolby digital if both are present).
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Added January 28, 2011 11:07 PM
A few of our top stories tonight in under 1 minute! We'll see you at 10 for more - KELO Sammi Bjelland
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Richard Montoya at Moss Theater April 3, 2014
Tonight I had the pleasure of attending the Los Angeles Chamber Orchestra's Westside Connections concert at the Moss Theater in Santa Monica. Their special guest was Richard Montoya, a very talented writer/actor/filmmaker. He read from his work, a delightful, very effective means of political satire, which I found both extremely funny and often right on target.
The musicians were all excellent, and the special program was curated and hosted by the adventurous Margaret Batjer. I particularly enjoyed the Trio for Harp, Flute and Viola by Chavez, and especially the Dvorak String Quartet No. 12. The Dvorak soared exquisitely, and the four musicians were especially well-blended and moved as one. Wonderful music and performances all around!
For more information about the Los Angeles Chamber Orchestra, visit laco.org. For more about Mr. Montoya, visit the Culture Clash website, he is a member: cultureclash.com.
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Girls to the Rescue Book #5: Tales of Clever, Courageous Girls from Around the World - eBook
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Product Information
|Format: DRM Protected ePub
Vendor: Meadowbrook
Publication Date: 2011
Availability: In Stock
Ages: 9-12
Series: Girls to the Rescue
Publisher's Description
In most heroic tales, a helpless young lady waits around for a prince to rescue her. But the spunky girls in this entertaining series are much too busy saving the day to await Prince Charming. These adaptations and original stories from around the world inspire readers to become a new kind of heroine. If you enjoy the stories in this book, look for more fun adventures in the other books in the series.
This fifth book in the series contains the following short stories: "Tulia!" (an original story), "Dingo Trouble" (an original story), "Railroad Through and Through" (an original story), "Gabrielle and the Polar Bears" (an original story), "Tricking the Wolves" (an original story), "To Catch a Cat" (an original story), "Rachel's War" (an original story), "Anna's Mystery (an original story), "The Clever Daughter" (an original story), and "Like Father, Like Daughter" (adapted from a Yiddish folktale).
Author Bio
Editorial Reviews
"Girls to the Rescue turns a new page and Prince Charming is history." --Sally Han, New York Daily News
"Inspiring" --Mary Hance, Nashville Banner
"Must reading." --Lee Littlewood, Copley News Service
"Provides positive female role models." --Nicole Bondi, The Detroit News
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A novel by Anthony Burgess
Richardson's clever ghost-busting follow-up to her solid urban fantasy debut (2006'sGreywalker) finds psychic Seattle PI Harper Blaine investigating a deadly lab-made spook. Pacific Northwest University professor and psychologist Gartner Tuckman is trying … see full wiki
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A novel by Anthony Burgess
A collection of Far Side comics
A book by Bruce Warren


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Obama vs. Romney: Sizing up the electric industry's winners and losers
By Doug Houseman
Having looked at the Energy Policy Guidelines on both President Barack Obama's website and that of former Massachusetts Governor Mitt Romney, the one thing that is for sure is that they lack details. But that said, it's still worthwhile to sort out the winners and losers in the electric industry under each person as president (assuming that they could get all of their energy policy in place).
The results are pretty stark. The positions of both candidates, while light in detail, point to very different winners and losers. It is slightly surprising to see how different the policies really are when you look at them in a winners/losers context as I have done below. (In all cases, the winners and losers described here focus on U.S. based companies. What will happen to foreign companies and their exports to the U.S. is not part of this analysis.)
Under Obama
· Wind and solar manufacturers, installers and owners
· Battery manufacturers
· Cleantech manufacturers
· Electric vehicles and electric vehicle infrastructure manufacturers and installers
· Nuclear manufacturers, engineers and installers - Reading carefully you will find that it will be impossible to build a plant under an Obama Administration, even though a quick read sounds positive.
· New transmission infrastructure - Regulatory hurdles will slow any investment significantly.
· Appliance manufacturers - Increasing efficiency standards will hurt overall profitability and drive down sales as prices rise to deal with the increased cost from changes to design.
· State regulators and RTO/ISO - Look for increasing federal regulation, reducing the ability of any state or market to make policy decisions.
· Small hydro and other non-conventional renewables - President Obama has been silent on these issues. Many have strong opponents.
Under Romney
· Nuclear manufacturers, engineers and installers - With the changes in regulations, expect any utility that has a site available will want to get a shovel in the ground within two years.
· Gas pipeline and electric transmission engineers and installers - With the reduction in regulation, both industries will be able move forward.
· Basic research firms and universities - look for money to be re-targeted to basic research and small grants for startups through ARPA-E and the National Science Foundation.
· State regulators - We should see a reduction in new regulations at the federal level that push on the boundaries between federal and state jurisdiction. Some new and some proposed federal regulations may be scrapped as part of the reduction in regulation effort.
· Energy markets - Expect FERC to review energy market rules and roll back some of them making energy markets more open. Also expect that many rules now in process to reduce emissions or force other changes will move to a market mechanism where possible.
· Small hydro - This is a low-cost way to increase renewable energy and make use of existing structures or run-of-the-river hydro. Reduction in regulation should open hundreds of small dams for repowering.
· Wind and solar manufacturers, installers and owners - Reduction in subsidies, loans and grants will reduce incentives to build. State renewable portfolio standards will drive a significant amount of construction, but the level of profit will decline for owners.
· Cleantech - Subsidies and regulations that require cleantech may disappear, reducing the profit available in the market. Expect strong export support for surviving companies.
· Battery and EV manufacturers - Romney is silent about electric transportation.
This analysis is based of material provided by the candidates websites and has not been reviewed with either candidate or their staff. I would welcome a chance to discuss this analysis and have corrections made by either candidate or their senior staff.
Doug Houseman is Vice President of Technology Innovation at EnerNex.


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MEXICO CITY (AP) — Mexico's state-owned oil company said rescuers have found another body amid the rubble of a headquarters building damaged by a still-unexplained blast. The find raises the death toll of Thursday's explosion to 34 people.
Petroleos Mexicanos operations director Carlos Murrieta said rescue crews are still looking for three people in the rubble, and believe they're in the most damaged part of the building.
Officials still have not given any cause for the explosion, though they have said they suspect it was an accident. The blast also injured 121 people.
Rescuers had concluded their search Friday but resumed operations when they suspected more bodies were in the rubble. The latest body was found Saturday, and the news was announced via Twitter by Mexican President Enrique Pena Nieto.
Rescuers find body in oil company blast
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Search the Collection
Marsha Hunt (1947-), Model, singer, actress and writer
Sitter in 5 portraits
Model, singer, actress and writer. American-born Marsha Hunt first came to prominence starring in the rock musical Hair in London in 1968. Her relationship with Mick Jagger led to the birth of their daughter Karis. Her acting career included appearances in Dracula AD 1972 (1972) and the Lindsay Anderson directed Britannia Hospital (1982). In 1990 she played Bianca in the Trevor Nunn directed television production of Othello. Since the late 1980s Hunt has published a number of books including Joy (1990) and Free (1994).
by Peter Gidal
16mm silent, black and white film, 1969
by Thomas Patrick John Anson, 5th Earl of Lichfield
archival inkjet print, October 1968
NPG x128488
by Horace Ové
giclée print, 1968
NPG x126726
by Lewis Morley
cibachrome print from original transparency
NPG x87168
by Robert Taylor
bromide print, 1993
NPG x45782


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IMO the Reds' failure to hit right handed pitching well was one of its serious issues in 2011. The team was excellent v. LH pitching, but the numbers were far worse against righties.
There were a number of hitters with over 150 at bats who didn't hit righties well. They are (excluding pitchers), using the OPS measure:
Cairo - .700
Hanigan - .685
Lewis - .683
Gomes - .654
Rolen - .648
Stubbs - .636
Renteria - .623
Janish - .531
Again, this is OPS against right handed pitching.
The Reds have potential to improve in this area. Several of these players are gone or unlikely to be with the big club. Hanigan's .685 isn't terrible for a catcher who hits lefties better.
Rolen will hopefully be healthier and supplemented by Francisco who hits righties MUCH better than he hits lefties. Hitting RHP is his forte.
Stubbs, picking up from the Stubbs thread, hopefully will sit against some tough righties, with Heisey and Ludwick needing some playing time -- they each generally hit righties better than Drew.
The Reds don't have a lot of lefty bats, it's Votto, Bruce, Francisco, Willie Harris when he is up with the club, that's mostly about it.
So even without a major infusion of lefty hitting this off-season, I'm hoping the Reds perform better against RHP this coming year.


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(Please welcome in the comments Charlie Savage, author of Takeover: The Return of the Imperial Presidency and the Subversion of American Democracy and winner of the Pulitzer Prize for his work on Bush's signing statements — JH)
Ever since The New York Times revealed the illegal NSA warrantless surveillance program in December, 2005, it has been inescapably clear that the Bush administration is a lawless government, grounded in the belief that nothing — certainly not the rule of law — can limit the President's powers. Despite how extraordinary this revelation was, very few establishment journalists paid any attention to it at all, and when they did, it was to defend this lawlessness and demand that nothing be done to impede it.
In January, 2006, Joe Klein in Time attacked Nancy Pelosi for daring to speak out against Bush's NSA lawbreaking and said: "these concerns [i.e., that Bush's eavesdropping is illegal] pale before the importance of the program. It would have been a scandal if the NSA had not been using these tools to track down the bad guys."
In Newsweek, Eleanor Clift in March, 2006 attacked Russ Feingold for daring to argue that Bush should be censured for his lawbreaking, claiming that Feingold's efforts to impede Bush's lawbreaking will doom the Democrats by showing how "unserious" they are with national security: "The broader public sees [Feingold's efforts] as political extremism. Just when the Republicans looked like they were coming unhinged, the Democrats serve up a refresher course on why they can't be trusted with the keys to the country."
The New Republic repeatedly ran articles –and still does — excusing, justifying and defending Bush's lawbreaking. And even through today, establishment-worshipping "journalists" such as The Washington Post's David Ignatius continue to insist that Democrats must not stand in the way of ever-increasing Presidential powers vested in George Bush — whether that means legalizing more and more warrantless eavesdropping and even providing retroactive liability to lawbreaking telecoms — and that if they do impede any of this, they will be guilty of the Ultimate Beltway Sin: insufficient bipartisanship.
George Bush has been able to pursue an agenda of truly radical executive power theories with impunity because most American journalists have not only stood meekly by and expressed no interest in investigating or exposing any of this conduct, but worse, they have actively defended it. That is why the truly superb and tenacious reporting of The Boston Globe's Charlie Savage has stood out so nobly and conspicuously. While most of the political press in this country eagerly served as mindless vessels for White House claims about its conduct, Savage actually scrutinized and investigated those claims, exposed how they were false, and tenaciously documented the lawlessness and radicalism of this administration. Put another way, Savage acted as a political journalist should.
Beginning in early 2006, Savage published a series of probing articles in The Globe documenting the various ways the administration was subverting the law — from signing statements to absurd theories of executive power which administration radicals led by Dick Cheney had long embraced. Savage's reporting almost single-handedly forced the issue of the President's signing statements into the public eye, and led to Senate hearings held by the Senate Judiciary Committee.
Earlier this year, Savage was awarded a Pulitzer Prize for his reporting on the administration's executive power abuses. When the Pulitzer was announced, the Globe's editor provided this explanation — at once unremarkable and extraordinary — as to why Savage deserved the Pulitzer:
What Charlie does and the reason he won this richly deserved Pulitzer is because he covered what the White House does, not just what it says.
More than anything, that is a sad though powerful commentary on the sorry state of our country's political press. Previously, reporting on "what the government does, not just what it says" was the basic function of political journalism. But these days, journalists who actually do that are so rare — they stand out so conspicuously — that they now win Pulitzer Prizes for it.
Savage has now expanded dramatically on the Pulitzer-winning reporting he did throughout 2006 with his invaluable new book, entitled Takeover: The Return of the Imperial Presidency and the Subversion of American Democracy. There have been several previous books documenting just how radical and democracy-subverting are the Bush administration's executive power abuses, but the true value of Savage's book is to assemble all of the facts over the last six years and prove conclusively that virtually every Bush scandal — from eavesdropping and torture to U.S. attorneys dismissals and the politicization of virtually every branch of our government — all stem from the same common root: the decades-long quest by hard-right radicals to transform the nature of our government beyond recognition by vesting virtually unlimited power in the President.
One of the oft-overlooked aspects of these executive power scandals is how central these theories have been — for decades — to the most powerful administration officials, beginning with Dick Cheney, who has vowed since his time in the Ford White House to restore what he views as the majesty of the executive branch. Even for those well-versed in most of the current presidential power controversies, Savage's book makes the uniquely clear case that virtually everything this administration has done domestically — such as the nominations of John Roberts and Sam Alito, both Reagan DOJ ideologues and long-time executive-power-worshippers — has been devoted to advancing the Cheney worldview of an imperial presidency.
Savage is a reporter, not a polemicist, at his core, and his methods here are the pure stuff of solid, fact-based journalism. There are little dramatic flourishes because the facts which Savage has assembled speak loudly and disturbingly for themselves. Because Savage's book comes so close to the end of the Bush presidency (though not close enough), Takeover will certainly be one of the definitive accounts of how this administration has so fundamentally transformed the type of country we are.


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41 year old woman | Palmyra, NE, USA | Seeking men 33-46 within 100 miles of Syracuse, NY
CAUTION: multifaceted, flawed, sincere, fun-loving, introspective, slightly academic, human being for your perusal
Probably Match is a bit like applying to grad school. At least every time I've gone to grad school (and admittedly, that's been a few times) I've learned you think you know what you are getting into from the online profile of the school; you think you know what it will be like; you think you know what you want in a grad school. But probably you don't. Not until you're there. Sometimes it's not great. Sometimes it's much better than you thought. Because everything does NOT happen for a grand reason. Things happen for lots of little reasons, but on the days when I believe in God, I don't think God micromanages us in accordance with some divine master narrative. So, perhaps I am the most unromantic woman on the planet, but mostly I think Match.com, or any way of dating, is like applying to grad schools. As my friend said when I was applying for my current PhD program: throw some spaghetti at the wall and see what sticks. So this is me, throwing spaghetti at the wall. I've done a lot with education in my life, but education takes many forms. I like to travel, though I've not yet ventured beyond North America and Europe. I love the outdoors, but a lot less so in winter. I am addicted to creativity. My hobbies vary from sewing to cooking to building furniture to gardening to throwing an exceptional dinner party. I have a geeky streak a mile long. At the same time, I really dig fashion. Also dry, red wine. I have terrible taste in music except that I love jazz. My choice in movies is also suspect, but I see the really ridiculous ones on my own. I am not, in any way, a vegetarian—but I do eat a lot of vegetables. My favorite holiday is the 4th of July 'cause I love blowing stuff up and because my mom always starts a squirt-gun fight which escalates to water balloons and ends up with someone getting the hose directly in their face. I've never been married. Never lived with anyone. I don't think this is a red flag, but you can judge for yourself. I've been in love at least once, maybe more. Love is a sliding scale. I've spent a lot of time thinking about my career. Sometimes my attention has been taken by family or friends or a hobby, even a man here and there. "They" tell me I've just not met "the right person," but I tend to think that I've just been unlucky in love. You see, I've been really, really lucky in almost every other area of life. But now, and this isn't the first time, I am turning back to the search for someone to hang out with, a lot, in my life. I'll tell you more about any of this if want to be one of those pieces of stubborn pasta. Warning though: I am probably an acquired taste. I won't fit with ultra-serious men because I love to laugh—I have a rather obnoxious laugh I am told—and I find being absurd from time to time invigorating. On the other hand, I do have a very serious side. We probably won't make it past the first date if you don't like thinking. You definitely don't have to be into school, but I hope whatever it is that you do with your life is something you'd like to share with me. Likewise I'd like to share a little of what I do with you. I have some convictions. I can be stubborn and argumentative and suddenly incredibly vulnerable. I live in NE in the summers and want to end up there eventually. As for what I want. . . I suppose kindness, companionship, connection, maybe eventually love, passion, mutual support-- the things anyone wants. I'd like someone who is responsible and just a little refined, but also impulsive from time to time. I am drawn to confidence and vulnerability, to intelligence and wit, to risk-takers, to leaders and to quiet observers who casually come up with the brilliant solution, to the guy who is excellent in a crisis, the guy you go to in order to get things done, to men who call their mothers and sisters from time to time, to guys who send their grandmas birthday cards—on time. Or none of those things. Someone in his 30s or 40s.
Book club , Camping , Coffee and conversation , Cooking , Dining out , Gardening/Landscaping , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing cards , Political interests , Religion/Spiritual , Travel/Sightseeing , Video games , Volunteering , Wine tasting
Billiards / Pool, Bowling, Dancing, Hockey, Running, Swimming, Walking / Hiking
I exercise 3-4 times per week.
I don't believe in astrology
I have Fish
Allergic to cats.
Middle of the Road
I live in upstate New York working on my PhD right now, but spend summers in Nebraska. For vacation I am all about mountains (and sometimes beaches), but cities (New York, etc.) have their draws too. I hope someday to go around the world-- slowly
It's hard to describe what I love as I am always finding new loves , but I adore art, shiraz, geeky games, accents, camping, The West Wing, Russian lit., creme brulee, gardening, films, dancing, Johnny Cash, The Flaming Lips, little black dresses
I like to dance, read, write, watch movies, play poker, play board games, garden, do creative stuff like paint.
Levinas, for school. Before that, The Grey Wolf Throne series
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'10" (177cms)
|5'8" (172cms) to 8'11" (271cms)
|Body type:
|About average
|Slender, About average, Athletic and toned, A few extra pounds
|No preference
|Dark blonde
|No preference
|No Way
|No Way, Occasionally
|Social Drinker
|No preference
|Education / Teacher / Professor
|No preference
T.A. in Religion at a University. Had been an adjunct professor in English for 8 years before that.
|$35,001 to $50,000
|No preference
|Never Married
|Never Married, Widow / Widower, Divorced
|Have kids:
|No preference
|Wants kids:
|Not sure
|No preference
|White / Caucasian
|No preference
|Christian / Protestant
|Agnostic, Christian / Catholic, Christian / Protestant, Jewish, Spiritual but not religious, Other, Christian / Other
I am certainly a Protestant, but theologically very liberal. God is important to me, but it might take you a while to figure that out if we met on the street. Seeking to understand God, in whatever form God comes, is the most central pursuit in life
|Graduate degree
|Bachelors degree, Graduate degree, PhD / Post Doctoral
Yeah, well, I sort of make a habit of education. I am on the last leg of a very long journey. Education is, obviously, important to me or I wouldn't teach, but I think that education comes in many forms, formal and otherwise.


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Swedish Possessions: Pomerania. Christina of Sweden Taler 1642,...
2014 January 14 - 16 Selections From the Eric P. Newman Collection Part III Signature Auction - New York #3029
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Heritage Auctions
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New York, NY 10022
|Printable auction results for all items in the 2014 January 14 - 16 Selections From the Eric P. Newman Collection Part III Signature Auction - New York.
1642 Christina of Sweden TalerPomerania. Christina of Sweden Taler 1642, Stettin mint, Ahlström-16, bust with curly locks, KM193.2, Dav-4573, MS63 NGC. A choice piece with gold and gray patina, one tiny natural edge flaw at 10 o'clock on the obverse. The bust is quite boldly struck and the overall eye appeal is excellent. Highly elusive in mint state. This piece has that old-time cabinet feel.
Highly Attractive Issue of Pomerania
Highly Attractive Issue of Pomerania
Ex: "Colonel" E.H.R. Green; Green Estate' Partnership of Eric P Newman / B.G. Johnson.
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Welcome to the world of AQUARIANCE
Here at Aquariance we are all about service. We come to your home or business for all your aquarium needs: aquarium cleaning, aquarium equipment, aquarium maintenance, livestock delivery/installation, etc. Browse our site to learn more about us and our services. You can also visit our Facebook page or Twitter as well via the links at the bottom of each page on this site.