text:
Rated 3.8 out of 5 by 436 reviewers.
Rated 1 out of 5 by venky Few employees with real bad attitude Few employees with real bad attitude Had issues with billing and had to make four calls to get it fixed April 4, 2013
Rated 4 out of 5 by WineAdvisoryGroup Good for Brooklyn This is a nice place, they try hard to please the guests, but not many services. Good for what it is. Gave us a larger room, not a suite, as a Platinum member. Can get congested with the traffic in the area. April 3, 2013
Rated 5 out of 5 by Heather97 this hotel was family friendly and accomodating We brought our children ages 9 and 12 and they were happy to be here and felt welcome anywhere we ventured. the business travelers were also very friendly to our family. March 30, 2013
Rated 5 out of 5 by Julie65 Sheraton Brooklyn was great Hotel and staff were great! I was originally to be in a room by the elevators, but being a light sleeper, I requested a room further away. The staff readily granted my request and moved me to another room. Room was very nice. Bed and bathroom were very comfortable. March 26, 2013
Rated 5 out of 5 by losann22 excellent hotel great customer service Great location, enjoyed complentary breakfast, very comfortable beds and great staffs that asisted me very well. The only downfall was overcharged on my check out date waiting on for thsi to be disputed. Other than great will stay here again. March 26, 2013
Rated 2 out of 5 by DRDC Uncomfortable and inconvenience First of all elevator was horrible, didn't work even after using my door key. I had to come down and had to change the key three times to work. Toilet clogged even after reporting to desk. Equipment was non functioning, engineer had to come repeatedly to correct. I called every time, the person took hours to come. The whole stay was not only bad but irritating. March 26, 2013
Rated 2 out of 5 by TKreview Needs much improvement the hotel was all in all okay. but the restaurant was horrible service. had several meals and routinely took 20 minutes for hamburger to arrive. for kecthup i was give PC packs...NOT bottle.. March 25, 2013
Rated 1 out of 5 Central location Central location But poor service Expensive parking! March 25, 2013
Rated 5 out of 5 by Chloe14 A wonderful staff The staff was so helpful and everyone had pleasant dispositions. I would definitely recommend this hotel to others. March 18, 2013
Rated 4 out of 5 by KoD1966 march madness Good location, parking was issue which staff did not address which compounded the situation March 17, 2013
Rated 3 out of 5 by BklynDee Avg Stay My first stay at the hotel was better. This time I had to keep call the front desk to have items fixed in the room. The room sizes are also hit or miss. Some rooms are average size and other are very, very tiny. My room was very small but had a great view. March 16, 2013
Rated 4 out of 5 by HGA1 Brooklyn Stay I did have to wait for some time to check in but the staff was very kind and helpful. The white comforter on the bed was stained. I did not call hotel staff about it. I simply removed it. Bathroom shower had some mold. Perhaps these two things should be looked at by room maids to ensure this does not occur. Restaurant in hotel service was good yet steaks were below par for a steakhouse. Nice hotel overall. I would stay again. March 15, 2013
Rated 3 out of 5 by Steve2013 The Brand is good Overall the brand is good however I was not impressed with the service. March 13, 2013
Rated 5 out of 5 by QHawk Northern Hospitality Marie and her staff are not only the best…they make it look easy. Most hotels miss on some of the small things…this is not most hotels. There is a true sense of a home away from home. March 12, 2013
Rated 4 out of 5 by Ken8 Mostly Great Hotel staff were exceptionally friendly and helpful. Hotel is difficult to find on a short, one-way street with lots of construction. Our cab driver could not find it and took over 45 min and two calls to the hotel front desk to locate it. Rooms were clean and quiet. Any request was immediately answered with one exception. We slept in on Sunday and when we left the hotel at 11 AM we requested that our room be made up. When we returned at 6 PM the room had not been cleaned. We waited two additional hours with multiple requests to the front desk before our room was made up. Hotel is close to many subway trains which made it easy to access downtown NYC. March 12, 2013
Rated 5 out of 5 by Scobie A great nights sleep..really I spend way too many nights in hotels, and usually I don't sleep very well. But the beds at the Sheraton Brooklyn were almost as good as mine at home (minus the dogs). Great hotel at a convenient location. March 11, 2013
Rated 5 out of 5 by Sam43now Clean and nice everything great! Limo services, received packages. March 10, 2013
Rated 5 out of 5 by doedy1 In a time when goood service is important I came to brooklyn because my dad was sick. The service was outstanding. The staff wwas knowledgeable and eager to serve. They even help me think through choices I had to make for traveling back and forth to see my dad. In my time of need it was nice to have a freindly, professional hotel staff to help me think things through with excellent service. March 5, 2013
Rated 5 out of 5 by JayDee28 Great Hotel 1st time back home in NY and I decided to come up for my birthday weekend. Everything about the hotel met my expectations. March 4, 2013
Rated 5 out of 5 by Howard Great Place to Stay I started staying at the Sheraton in Brooklyn several months ago and have been staying there ever since. The people are friendly and caring. The rooms are clean and are in grat condition. This hotel is what Sheraton is all about. March 3, 2013
Rated 5 out of 5 by Walker12 This is a great hotel Although the buffet breakfast price is a little overpriced for the food selection, our overall experience was excellent. The stafff was always greeted us, smiled, and eager to assist whenever we had questions. Great staff. February 26, 2013
Rated 4 out of 5 Convenient Location I had a business meeting to attend and it was scheduled for this hotel. It was convenient to downtown Brooklyn. Juniors restaurant not far away (and had already known of its fame for cheesecake). Breakfast was disappointing--the bagel was not a fresh NYC bagel. On the second morning, found a sidewalk vendor on Fulton with delicious, fresh food for 1/2 the price. February 25, 2013
Rated 4 out of 5 by NAT2MJM WiFi not so good I spent half an hour on the phone to India to get the WiFi to work. The WiFi wasn't included within the room rate The WiFi went out several times in the middle of the session February 24, 2013
Rated 5 out of 5 by elg2013 Courtesy, knowledgeable and helpful staff The facility is current. The staff was excellent. The front desk staff at check in the evening of February 21, 2013 was some of the most friendly, courteous and helpful I have ever met. February 24, 2013
Rated 4 out of 5 by Bostonian Convenient hotel in downtown Brooklyn We like the location & convenience factor. We require very little from the staff & they deliver friendly check in services. We have stayed here five times. February 24, 2013
Rated 5 out of 5 by SusanandBob Will definitely stay here again The staff made us feel right at home during our 3-day stay in Brooklyn! February 23, 2013
Rated 5 out of 5 by Sheri Great staff Clean environment, friendly staff and good food. February 20, 2013
Rated 3 out of 5 by TravelTom Nice hotel, lots of quirks We stayed over a long weekend with club level access and had a generally nice stay. The good: Super comfy bed, pleasant responsive staff, very clean rooms, subway a block away and you could walk to a lot of great locations in Brooklyn in 5-10 minutes. The quirks: The immediate neighbor hood is up and coming / isolated. Our room had a deck with a leaky door (a bit windy/cold). The elevators were very slow and the key access to use them was difficult to use and sometimes didn't work. Not sure why there wasn't a toaster at breakfast in the club level two days in a row, and the lobby is oddly configured and small (difficult to navigate). February 19, 2013
Rated 3 out of 5 by CRUSH Hotel is nice but no bar until 5:00 pm and terrible location are big negatives. Hotel was nice and staff was very friendly and helpful. However, location is terrible. We were in town for a wedding and thus had Friday afternoon and Saturday afternoon free - so we thought we would go to the bar to set around and talk with friends. Not possible - the bar does not open until 5:00 pm. So my wife and I walked out to find a bar - dirty, empty storefronts, people sleeping on the street, etc. (looked like a war zone). On one corner we saw 8 policeman on patrol (two on each corner). My wife had on a fur and her diamond rings - one couple and one policeman came up to us to ask if we were lost (I can only assume they were concerned about our safety). Would have been nice if the bar had opened at noon on Fridays and Saturdays. If you stay at this hotel and will have any down town, plan on spending it in your room. February 18, 2013
Rated 3 out of 5 by Paolo Value for Money in Brooklyn, NY! Although the hotel is rather difficult to find for the taxi drivers, it is well located in downtown Brooklyn on the subway. No 24-hour room service but access to Club Lounge for breakfast and pop. Internet access by Wi-Fi free. Great value for monewy! February 18, 2013


text:
Dolphin offers waterproof bathroom TVs
Dolphin is offering stylish waterproof flat screen TVs as an option for those going for the company's designer bathrooms.
Available in two sizes, a teeny 7-incher and a 17-inch model, the televisions are suitable for all wet environments.
Featuring a built-in Freeview digital tuner, the TVs also offer a splash-proof floating remote control, separate splash-proof speakers, and crucially, a heated glass screen to keep 'em steam-free.
In addition, the 17-inch model transforms into a mirror when the TV is switched off.
A fully fitted Dolphin Bathroom starts from £7500 which includes full design, technical survey, delivery and complete installation.

subset: commoncrawl


text:
Date: May 6, 2011
Place: Room 1D
1000 Washington Street ,
Boston , MA 02118
Time: 9:30 am
II. Review Regular minutes from the April 1, 2011 Meeting
III. TEC Applications/Provisional Certificates
• Webster Water Department, TEC #464
IV. TCH Applications
V. Report from Board Counsel
• ABC/AMP Update
VI. Items from Board Chairman
Drinking Water Exam Fees
VII. Miscellaneous
VIII. Adjournment


text:
Chicago hockey fans ages 14 and under are invited to join Tommy's Crew. For just $25, Tommy's Crew members will receive access to exclusive events, a birthday card from Tommy, a Tommy Hawk gift bag, email updates about special events and contests, and more! You don't want to miss out on this all-access pass featuring Tommy Hawk and his favorite team, the Chicago Blackhawks!
I am a RETURNING member, please renew my membership!
I want to JOIN the club, please sign me up!
Tommy's Crew membership runs from October 2014-September 2015. Gift bag items and kids club events are subject to change. For more information, please email Joe Doyle email@example.com.


text:
Release Date
May 6, 2011 (Limited)
Running Time
96 minutes
MPAA Rating
Rated R for drug and alcohol use, sexual content, language and some violent images -- all involving teens
Seventeen-year-old Caroline Wexler (Kat Dennings) is facing a teenager's nightmare: her widowed father has moved them from the big city to a tiny town in the middle of nowhere. When Caroline realizes she has nothing in common with the burnout losers in her new school she pursues the one person with who excites her interest – her handsome young teacher, Mr. Anderson (Josh Lucas). A bizarre love triangle ensues between Caroline, Mr. Anderson, and a... Full synopsis »
This movie review is currently away from the desk. Please come again.


text:
Originally written on cheap-heat | Last updated 2/11/13
PWInsider is reporting The Shield vs. John Cena, Ryback and Sheamus at the Elimination Chamber pay-per-view will be inside the Chamber structure. This would be the first time a six-man tag match has taken place inside the Chamber. Their report suggests that the match would be conducted under rules similar to the old War Games: The Match Beyond. The Chamber was actually created after Triple H pitched using the Wargames double ring cage structure, only to have the idea shot down and the Chamber created instead.
Comments are closed.
What do you think?To leave a comment, you can:
WWE News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
Follow us on Twitter
|Best of Yardbarker
|NFL News
|MLB News
Today's Best Stuff
For Bloggers
Join the Yardbarker Network for more promotion, traffic, and money.
Company Info
What is Yardbarker?
Yardbarker is the largest network of sports blogs and pro athlete blogs on the web. This site is the hub of the Yardbarker Network, where our editors and algorithms curate the best sports content from our network and beyond.
|© 2015 Yardbarker, Inc. All rights reserved. Use of this website (including any and all parts and components) constitutes your acceptance of these Terms of Use and Privacy Policy. (What's New?)


text:
Customers Who Bought This Product Also Bought
Newcomer Cindy "Oh My" Lords knows how to take an ass stuffing as her tank gets filled to the brim! Kitty Sixx and Pamela take an olympic anal pounding as they get their round tight asses stuffed full of hot cum! Don't you dare miss this ass stuffing event!
Product Information
DetailLength 2 hrs. 13 mins.
Rating XXX
Released Mar 01 2005
Added Feb 28 2005
Production Year 2005
Empire SKU 668963
Studio Devil's Film
Number of Discs 1
UPC Code 600236002979
Interactive Menus
Chapter Selection
Bonus Scene
Slide Show
Web Site Information
- Julie Silver
- Pamela Kayne
- Cindy Lords
- Nikki Montana
- Kyana (Canadian)
- Kitty Sixx
- Ian Scott
- Tristan Seagal
- Wein Lewis
Anal, Cream Pie, Cumshots, Gonzo
Bargains$10 to $19.99
- Christoph's Beautiful Girls 14
- Incredible Gulp 2, The


text:
To fulfill the model based drug development, the very first step is usually a model establishment from published literatures. Pharmacokinetics model is the central piece of model based drug development. This paper proposed an important approach to transform published non-compartment model pharmacokinetics (PK) parameters into compartment model PK parameters. This meta-analysis was performed with a multivariate nonlinear mixed model. A conditional first-order linearization approach was developed for statistical estimation and inference.
Using MDZ as an example, we showed that this approach successfully transformed 6 non-compartment model PK parameters from 10 publications into 5 compartment model PK parameters. In simulation studies, we showed that this multivariate nonlinear mixed model had little relative bias (<1%) in estimating compartment model PK parameters if all non-compartment PK parameters were reported in every study. If there missing non-compartment PK parameters existed in some published literatures, the relative bias of compartment model PK parameter was still small (<3%). The 95% coverage probabilities of these PK parameter estimates were above 85%.
This non-compartment model PK parameter transformation into compartment model meta-analysis approach possesses valid statistical inference. It can be routinely used for model based drug development.
In recent decades, a new drug requires an average of 15 years and approaching a billion dollars in research and development [1]. Unfortunately, only one in 10 drugs that enter clinical testing receives eventual FDA approval [2,3]. Scientists have become increasingly mechanistic in their approach to drug development [4]. The recent ability to integrate genetic mutations and altered protein expression to pharmacokinetics (PK) and pharmacodynamic (PD) models allow a deeper understanding of the mechanisms of disease and therapies that are genuinely targeted [5-8]. In 2004, the FDA released a report entitled: "Innovation or Stagnation, Challenge and Opportunity on the Critical Path to New Medical Products" [9]. Among its six general topic areas, three of them emphasized the importance of computational modeling and bioinformatics in biomarker development and streamlining clinical trials [10,11]. In multiple follow-up papers, clinical researchers, experimental biologists, computational biologists, and biostatisticians from both academia and industry all supported the FDA leadership in this critical path, and pointed out the challenges and opportunities of the PK/PD model based approach in drug development [12][13-15].
Pharmacokinetics model is the central piece of model based drug development. Almost all of the published PK data were summarized without fitting a compartment model. They are usually called non-compartment model PK parameters. For example, area under the concentration curve (AUC) is calculated from drug plasma concentration data based on trapezoid-rule [16]; clearance is calculated from dose and AUC; Cmax and Tmax are calculated from concentrations and their associated time points; terminal half-life is usually calculated from the last two to four sampling time-points directly; and etc. All these parameters cannot be used directly in a compartment model, and their transformation to compartment model PK parameters is essential.
Non-Compartment Model to One-Compartment Model Transformation
When a drug follows a one-compartment model of oral dose (1), the following non-compartment model PK parameters, w = (AUC, Tmax, T1/2), are necessary to recover the one-compartment model parameters, β = (ka, ke, V).
where, F is an assumed known bioavailability, and dose denotes the oral dose. If however, only oral clearance, CLpo is reported, instead of AUC, then CL po = V × Ke. On the other hand, when dosing is through IV, only w = (AUC, T1/2), are necessary to recover the one compartment (3), with β = (ke, V). The transformation formulas are defined in (4).
Similarly, if CLiv is reported, instead of AUC, then CLIV = V × ke. These one-compartment-model and non-compartment model parameters and transformation were defined and discussed in great detail by [16].
Non-Compartment Model to Two-Compartment Model Transformation
If a drug's pharmacokinetics follows a two-compartment model with oral dose (5), the following non-compartment model PK parameters, w = (Vd, AUC, Tmax, CLiv, T1/2,slow, T1/2,fast), are necessary to recover the two-compartment model parameters, β = (ka, ke, V1, k12, k21). Their transformations are defined in (6).
If a drug's pharmacokinetics follows a two-compartment model with IV dose (7), the following non-compartment model PK parameters, w = (Vd, AUC, CLiv, T1/2, slow, T1/2, fast), are necessary to recover the two-compartment model parameters, β = (ke,V1, k12, k21). Their transformations are defined in (8).
A Multivariate Nonlinear Mixed Effect Model (Model Specification)
Based on the multiple transformation equations between non-compartment model PK parameters and one or two compartment models, a multivariate nonlinear mixed effect model is established to estimate the population level PK parameters and their between study variances. Denote wjk as the observed j th non-compartment PK parameter (j=1,…, Jk) from study k (k=1,..,K). Please note that not every study published all of the non-compartment parameters, hence Jk varies from study to study. βk is the study level compartment-model PK parameter vector, and gj (βk) represents the transformation function. Because non-compartment model PK parameter,wjk, is usually published in the form of a sample mean, model (9) shows that its variance is , where is the within study variance (assumed to be homogeneous across studies), and nk is study k sample size
Model (9) also shows that the observed non-compartment model parameters, , are independent. This is a multivariate nonlinear regression model.
Study level compartment model parameter βk is assumed to follow multivariate normal distribution (10), in which µ is the population PK parameter vector and Ωk is its general covariance matrix.
The joint likelihood of population/subject parameters and their covariance is shown in equation (11).
whereis a J×1 () observed non-compartment model PK parameter vector;is a J×p indicator matrix, and Xk is a Jk×p matrix indicating the corresponding transformation function; g(.) is a p×1 transformation function vector; is a study level compartment-model PK parameter vector; is a diagonal J×J covariance matrix for W, and ; is a Kp×p design matrix relating study-specific parameter β to population parameter µ, and Ik is an identity matrix; and is a Kp×Kp covariance matrix for study-specific parameter β.
This multivariate nonlinear mixed model (11) is different from the conventional univariate nonlinear mixed model [17] structurally in the additional design matrix X in front of the nonlinear function ( i.e. transformation function g(.)). Model (11) is a meta-analysis approach, in which sample mean non-compartment model PK parameters are formulated. Among the existing nonlinear mixed model meta-analysis literatures, some dealt with the subject-level data from multiple studies [18,19]; the others dealt with sample mean drug concentration data [20,21]; and none of them discussed the meta-analysis on summarized PK parameters through the non-compartment model.
A Multivariate Nonlinear Mixed Effect Model (Estimation and Inference)
As a conditional first order linearization approach provides the least biased estimate in estimating the PK parameter with comparable efficiency [22,23]), it is chosen as the estimation approach for this multivariate nonlinear mixed model. This conditional first order linearization approach was firstly introduced by Lindstrom and Bates [24]. We revise their derivation based on our special meta-analysis multivariate nonlinear mixed model (11). This two-step estimation scheme is described as following.
Step 1: given the current estimate of variance componentand, minimize the following objective function, L1, with respect to (β, µ).
Computationally, minimizing L1 on (β, µ) is an iterative process. Within each iteration, a linearization is applied to Xg(β) with respect to β, and a linear mixed model (13) is fitted [24].
Parameters (μ, b, β)'s estimates and their covariance are
Step 2: given the current estimate,, minimize the following objective function, L2 , with respect to θ, which is the variance component parameter vector in (Ω, Σ), and it is of dimension q.
This L2 likelihood function is the restricted maximum likelihood for variance component estimates. The scores and the elements of information matrix for θ are defined in (17).
Hence, θ can be estimated through an iterative Fisher algorithm. An alternative derivation of this two-step first order linearization is through a second order Laplace's approximation [25-27].
Midazolam Non-Compartment Model Parameters to Compartment Model Parameters Transformation Data Analysis
After extensive literature search, 10 midazolam pharmacokinetics studies were identified, and their published non-compartment PK parameters are reported in Table 1. (Cmax, AUC, T1/2,slow) were reported with high frequencies, i.e. 8 to 10 out 10 publications. T1/2,fast was published only twice. Both Vd and CLiv were published 5 to 6 times.
Table 1. Summary of Published Non-Compartment Model Midazolam Pharmacokinetics Parameters
A multivariate nonlinear mixed effect model is fitted to these published non-compartment PK parameters to estimate their compartment model PK parameters. The NONMEM code is reported in Appendix I. In this meta-analysis, between study variances are assumed for (V1, ka, k e). (k12, k21) were assumed to be the fixed effects across different studies without random effects, because only two papers published the MDZ distribution information, i.e. T1/2,fast. All of the non-compartment model parameters were log-transformed. They were assumed to have the same within study variance in log-scale (i.e. same coefficient of variance in the raw scale). All of the compartment model PK parameters were also log-transformed, and their between study standard deviations can be interpreted as coefficient of variance in raw scale.
Figure 1 displays the convergence plots for all five compartment PK parameters (V1, ka, k12, k21, ke). The x-axes are these PK parameters' domain, and the y-axes are the likelihood function (13). It appears that all these PK parameter estimates reach maximum likelihood, and we don't observe any non-identifiable parameters.
Figure 1. Convergence plots for five two-compartment midazolam pharmacokinetics parameters. The x-axes are log-transformed PK parameters, and y-axes are the log-likelihood functions. The dots on the top represent the maximum likelihood estimates.
Table 2 reported the PK parameter estimates. V1 = 33 L, ka = 0.68 1/h, k12 = 0.33 1/h, k21 = 0.27 1/h, and ke = 0.67 (1/h). Please notice that V1 has very small between study variances, CV= 10%; ka has high between study variance, CV = 84%; and ke's variation is moderate, CV = 23%. On the other hand, the within-study variation of reported non-compartment PK parameters is moderate, CV = 27%.
Table 2. Midazolam Compartment Model Pharmacokinetics Parameter Estimates
Simulation Studies
Simulation Schemes
The primary concern of this non-compartment PK parameter transformation to compartment model PK parameter is the bias of PK parameter estimates. Two simulation studies were designed to investigate this problem. In the first simulation, every non-compartment PK parameter was observed for each study. In the second simulation, the same amount of missing data as our MDZ example was assumed to be present.
In each simulation, 1000 simulated data sets were generated. Each data set had 10 studies, and each study reported either all (Cmax, AUC, T1/2,slow, T1/2,fast , Vd , CLiv) in simulation 1, or a partial amount of (Cmax, AUC, T1/2,slow, T1/2,fast , Vd , CLiv) in simulation 2. These non-compartment model PK parameters were simulated based on the two-compartment model transformation relationship (5) and (6), their meta-analysis multivariate nonlinear mixed model (9) and (10), and MDZ PK parameter estimates and variances from Table 2.
Simulation Evaluation Criteria
Both fixed effect and variance components were evaluated in the simulation studies. The bias was calculated as the relative bias: abs(true-est)/est; and their 95% coverage probabilities were also reported based on model based 95% confidence interval. Coverage probabilities outside of (92.93, 97.07) were highlighted. The half-width of this interval is three times the binomial stand error, which is [(95%)(5%)/1000]1/2=0.6892%. Standard error was also reported based on 1000 simulation results.
Simulation 1 (All Reported and No Missing Data)
Table 3 reported the simulation results. Among fixed effects, all of the relative biases are less than 1%. (V1, ka, k e) had lower 95% coverage probabilities than (K12, K21) did, because (V1, ka, k e) were assumed to have between study variances, but (K12, K21) didn't have. Therefore, the low 95% coverage probability was probably due to the under estimated standard error. On the other hand, the biases of between study variance estimates were between 5% and 12.8%, though their 95% CP were all around 95%.
Table 3. Simulation Results with No Missing Data
Simulation 2 (With Missing Data)
Table 4 reported the simulation results. Among fixed effects, all of the relative biases can be as high as 2.84% (i.e. ke). All of their 95% coverage probabilities were outside of the normal range, (92.93%, 97.07%). The low coverage of (V1, ka, k e) was probably due to their between subject variations; and the low coverage probability for k12 and high coverage for k21 were probably due to the missing data. As in the MDZ example, T1/2,fast had only 2 out of 10 papers published. On the other hand, the biases of between study variance estimates were between 3.6% and 9.8%, though their 95% CP were within (92.93%, 97.07%).
Table 4. Simulation Results with Missing Data
This paper proposed an important approach to transform published non-compartment model pharmacokinetics parameters into compartment model PK parameters. This meta-analysis was performed with a multivariate nonlinear mixed model. A conditional first-order linearization approach was developed for statistical estimation and inference, and it was implemented in R. Using MDZ as an example, we have shown that this approach transformed 6 non-compartment model PK parameters from 10 publications into 5 compartment model PK parameters, and the conditional first order linearization approach converged to the maximum likelihood. In the follow-up simulation studies, we have shown that our meta-analysis multivariate nonlinear mixed model had little relative bias (<1%) in estimating compartment model PK parameters if all non-compartment PK parameters were reported in every study. If there existed missing non-compartment PK parameters, the relative bias of compartment model PK parameter was still small (<3%). The 95% coverage probabilities of these PK parameter estimates were usually above 85% or more. Therefore, this approach possesses adequately valid inference.
Although this paper only showed the transformation performance of non-compartment model PK parameters to two-compartment model with oral dose PK parameters, we think it is probably the most complicated case among published drug PK studies. One compartment models and two-compartment model with IV dose have simpler transformation function and less computational expense.
Sometimes, not all of the required non-compartment model PK parameters are available in the literature. Whether it is feasible to transform these data into compartment model is an interesting and important question. In this paper, MDZ was chosen as an example. Because MDZ has been a well studied probe drug, its published non-compartment model PK parameters were expected to be rich. Other rarely studied drugs may not have all these published information, and their compartment model developments from literature need further investigations.
List of Abbreviations
AUC: area under the concentration curve; MDZ: Midazolam; PK: Pharmacokinetics.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
ZW developed the theory of multivariate nonlinear mixed effect model, and run the implementation; SK developed the theory of multivariate nonlinear mixed effect model; SKQ provided the MDZ example background; JZ integrated the compartment model non-compartment model transformation formulas; LL initialized the idea, and developed the model transformation schemes, confirmed the statistical theory, and wrote the paper.
Authors' information
ZW is currently a Ph.D. Computer Science student in the Indiana University; SK is an assistant professor in the University of Louisville; SKQ is an assistant professor in the Indiana University; JZ is a PhD student in the University of Michigan; and LL is an association professor in the Indiana University.
Dr. Lang Li is supported by NIH grants, R01 GM74217. Dr. Seongho Kim is partially supported by DOE grants, DE-EM0000197, and an Intramural Research Incentive Grant from the University of Louisville.
This article has been published as part of BMC Systems Biology Volume 4 Supplement 1, 2010: Proceedings of the ISIBM International Joint Conferences on Bioinformatics, Systems Biology and Intelligent Computing (IJCBS). The full contents of the supplement are available online at http://www.biomedcentral.com/1752-0509/4?issue=S1.
DiMasi JA, Hansen RW, Grabowski HG: The price of innovation: new estimates of drug development costs.
Journal of Health Economics 2003, 22(2):151-185. PubMed Abstract | Publisher Full Text
Kola I, Landis J: Can the pharmaceutical industry reduce attrition rates?
Nature Reviews Drug Discovery 2004, 3(8):711-715. PubMed Abstract | Publisher Full Text
Woosley RL: Drug development and the FDA's critical path initiative.
Veit M: New strategies for drug development.
Berl. Munch. Tierarztl. Wochenschr (117):276-287. PubMed Abstract
D'Andrea G e a: A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.
Blood 2005, (105):645-649. PubMed Abstract | Publisher Full Text
Kirchheiner JB: J. Clinical consequences of cytochrome P450 2C9 polymorphisms.
Clin. Pharmacol. Ther 2005, (77):1-16. PubMed Abstract | Publisher Full Text
Badagnani I e a: Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.
J. Pharmacol. Exp. Ther (318):521-529. PubMed Abstract | Publisher Full Text
Hung S I e a: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.
Pharmacogenet. Genom 2006, (16):297-306. Publisher Full Text
Cleary JD, Taylor JW, Chapman SW: Itraconazole in antifungal therapy.
Ann Pharmacother 1992, 26(4):502-9. PubMed Abstract
Yamazaki M, Nishigaki R, Suzuki H, Sugiyama Y: [Kinetic analysis of hepatobiliary transport of drugs, importance of carrier-mediated transport].
Yakugaku Zasshi 1995, 115(12):953-77. PubMed Abstract
Okuda H, Nishiyama T, Ogura K, Nagayama S, Ikeda K, Yamaguchi S, Nakamura Y, Kawaguchi Y, Watabe T: Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Lalonde RL, Hutmacher MM, Ewy W, Nichols DJ, Milligan PA, Corrigan BW, Lockwood PA, Marshall SA, Benincosa LJ, Tensfeldt TG, Parivar K, Amantea M, Glue P, Koide H, Miller R: Model-based drug development.
Clin Pharmacol Ther 2007, 82(1):21-32. PubMed Abstract | Publisher Full Text
Chang MKS, Bull J, Chiu YY, Wang W, Wakeford C, McCarthy K: Innovative approaches in drug development.
J Biopharm Stat 2007, 17(5):775-89. PubMed Abstract | Publisher Full Text
RT ON: FDA's critical path initiative: a perspective on contributions of biostatistics.
Biom J 2006, 48(4):559-64. PubMed Abstract | Publisher Full Text
Chien JY, Heathman MA, de Alwis DP, Sinha V: Pharmacokinetics/Pharmacodynamics and the stages of drug development: role of modeling and simulation.
The AAPS Journal 2005, 7(3):E544-E559. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Rowland M, Tozer TN: Clinical Pharmacokinetics Concept and Applications. Third edition. Lippincott Williams & Wilkins; 1995.
Davidian M, Giltinan DM: Nonlinear models for repeated measurment data. Chapman and Hall; 1995. PubMed Abstract | Publisher Full Text
Wakefield JC, Rahman N: The combination of population pharmacokinetic studies.
Biometrics 2000, 56(1):263-70. PubMed Abstract | Publisher Full Text
Lopes HF, Muller P, Rosner GL: Bayesian meta-analysis for longitudinal data models using multivariate mixture priors.
Biometrics 2003, 59(1):66-75. PubMed Abstract | Publisher Full Text
Li L, Yu M, Chin R, Lucksiri A, Flockhart D, Hall S: Drug-Drug Interaction Prediction: A Bayesian Meta-Analysis Approach.
Statistis in Medicine 2007, 26(20):3700-3721. Publisher Full Text
Yu M, et al.: A Bayesian meta-analysis on published sample mean and variance pharmacokinetic data with application to drug-drug interaction prediction.
J Biopharm Stat 2008, 18(6):1063-83. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Wolfinger RD: Two Taylor-series approximations methods for nonlinear mixed models.
Journal of Computational Statistics and Data Analysis 1997, 25:465-490. Publisher Full Text
Wolfinger R, O'Connell M: Generalized linear mixed models: a pseudo-likelihood approach.
Journal of statistical Computation and Simulation 1993, 48:233-243. Publisher Full Text
Lindstrom ML, Bates DM: Nonlinear mixed effects models for repeated measures data.
Biometrics 1990, 46(3):673-87. PubMed Abstract | Publisher Full Text
Wolfinger RD: Laplace's Approximation for Nonlinear Mixed Models.
Biometrika 1993, 80:791-795. Publisher Full Text
Westfall P, Hochberg Y, Wolfinger RD, Rorn D, Tobias RD: Multiple comparisons and Multiple Tests.
Vonesh EF: A Note on Laplace's Approximation in Nonlinear Mixed Effects Models.
Biometrika 1996, 83:447-452. Publisher Full Text


text:
Saturday, August 28, 2010
© Copyright 2015 Gwinnett Daily Post
Dirty Spokes Productions, a company that puts together mountain bike, trail running and duathlon races throughout the Southeast, will be hosting six trail running races starting this September as part of the 2010-11 XTERRA Georgia Trail Run Series.
Gwinnett's own Harbins Park in Dacula and the Gwinnett Environmental and Heritage Center in Buford are the first two stops of the series.
Harbins Park hosts the Harbins Park Run, a 6.2-mile trail run, on Sept. 25 with packet pickup starting at 7 a.m. and the race starting at 8:30 a.m. Early registration, which runs through Sept. 15, is $40.
The Gwinnett Environmental and Heritage center hosts Fall Fitness, a 5K trail run, on Oct. 2 with packet pickup starting at 7 a.m. and the race starting at 8:30 a.m. Early registration, which runs through Sept. 17, is $25.
Participants can register for as many or as few races as they like. Bags and T-shirts will be provided at pre-race registration for participants. The overall top three male and female finishers, in addition to the top three male and female finishers in each of the designated age groups, will be awarded medals at each event.
Points will also be awarded to the top 15 finishers in each age group at each of the six races of the series. If you enter all six races, your lowest score will dropped. The standings will updated at XTERRAPlanet.com after each race and the top scorer at the end of the six races will be named XTERRA Regional Trail Run Series Champion and will earn free entry into the XTERRA National Trail Run Championship.
Registration for the events is available online at www.dirtyspokes.com.
More like this story
- Local XTerra trail run events announced ( August 15, 2013 )
- Local XTerra trail running schedule announced ( September 4, 2012 )
- Marathon and half marathon return to Fort Yargo ( February 20, 2013 )
- XTerra running event in Buford this Saturday ( September 27, 2011 )
- Dirty Spokes race set for Feb. 25 at Ft. Yargo ( January 27, 2012 )


text:
Thanks for redeeming.{{else}}
Success! Thanks for repurchasing.{{/if}} {{else}} {{#if Expired}}
Increase my visibility!{{else}} {{#if IsMultiPack}}
{{#if HasMultiPack}} You have {{MultiPackCount}} top spot(s) left. Now loading you into the search listings... {{else}} You have used all top spots. Now loading you into the search listings... {{/if}}{{else}}
We are loading you into the search listing pages...{{/if}} {{/if}} {{/if}} {{/if}}
{{Current}} just saw you!{{/if}} {{#if LastTopSpotPurchaseIsMulti }} {{#if HasAnyTopSpot}}
{{#if HasFreeTopSpot }} {{ UnclaimedTopSpotFree }} Free {{/if}} {{#if HasPaidTopSpot }} {{#if HasFreeTopSpot }} & {{/if}} {{ MultiPackCount }} {{/if}} Top Spot{{#if Plural}}s{{/if}} Left{{else}}
0 Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{else}} {{#if HasFreeTopSpot }}
{{ UnclaimedTopSpotFree }} Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{/if}} {{else}} {{#if HasResults}}
{{Current}} see you now!{{else}} {{/if}} {{/if}}
You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
36 year old woman | Detroit, MI, USA | Seeking men 28-35 within 50 miles
Babbling Uncertainties
I am seeking to meet someone who wants to be in a relationship. This new dating craze has got me a lot of new friends and no takers... I'm looking for someone loving and humble... willing to give and not always be given to... I love to love and encourage people and spoiling my mate makes me smile. I am a cool and down to earth person... I am an artist and enjoy going to museums and galleries. I love concerts and live music... and pretty much enjoy exploring new things that will stimulate the mind and body. I'm not your average girl. I have a unique and relatable spirit. No need to send your representative to me because i am the coolest and most real woman you will ever meet...
Camping , Coffee and conversation , Cooking , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Playing sports , Wine tasting
Aerobics, Billiards / Pool, Bowling, Dancing, Other types of exercise, Walking / Hiking, Yoga
I exercise 1-2 times per week.
I have Dogs
I have a dog and her name is Puggy... she is my only child... LOL! She is a Pug if you can tell by her name and just as sweet as she wants to be.
Middle of the Road
I use to love to go to NY but have not been in a few years... Hmmm?!?! As a photographer I love many places. You will just have to come on an adventure with me one day :-)
Columbia College Chicago, Chicago, IL
I love soul music but I have an ear for all kinds. I don't have a television so I don't know what's on the tube these days. I love to cook... Entertaining and encouraging people lifts my spirit in return. I love to cuddle... Aint nothing like it :-)
I am an artist so I enjoy anything art... Going to museums, galleries, cultural events, and concerts. I love to explore all the new, fun and free stuff that goes on in my community :-) I also love to shoot pictures and exhibit them...
The art of seduction... Very good book and i enjoyed learning how to seduce people in to doing what I want them to do... however please know... The information just went in one ear and right out the other.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'5" (165cms)
|5'8" (172cms) to 8'11" (271cms)
|Body type:
|A few extra pounds
|Slender, About average, Athletic and toned
|No preference
|Auburn / Red
|No preference
|No Way
|No Way
|Social Drinker
|Never, Social Drinker
|Artistic / Creative / Performance
|No preference
Graphic Designer, Photographer, Teacher
|$35,001 to $50,000
|$25,001 to $35,000, $35,001 to $50,000, $50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000, $150,001+
|No preference
|Have kids:
|No preference
|Wants kids:
|Definitely, Someday
|Black / African descent
|No preference
|Spiritual but not religious
|No preference
|Bachelors degree
|Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


text:
Thanks for redeeming.{{else}}
Success! Thanks for repurchasing.{{/if}} {{else}} {{#if Expired}}
Increase my visibility!{{else}} {{#if IsMultiPack}}
{{#if HasMultiPack}} You have {{MultiPackCount}} top spot(s) left. Now loading you into the search listings... {{else}} You have used all top spots. Now loading you into the search listings... {{/if}}{{else}}
We are loading you into the search listing pages...{{/if}} {{/if}} {{/if}} {{/if}}
{{Current}} just saw you!{{/if}} {{#if LastTopSpotPurchaseIsMulti }} {{#if HasAnyTopSpot}}
{{#if HasFreeTopSpot }} {{ UnclaimedTopSpotFree }} Free {{/if}} {{#if HasPaidTopSpot }} {{#if HasFreeTopSpot }} & {{/if}} {{ MultiPackCount }} {{/if}} Top Spot{{#if Plural}}s{{/if}} Left{{else}}
0 Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{else}} {{#if HasFreeTopSpot }}
{{ UnclaimedTopSpotFree }} Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{/if}} {{else}} {{#if HasResults}}
{{Current}} see you now!{{else}} {{/if}} {{/if}}
You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
39 year old man | Boston, MA, USA | Seeking men 25-45 within 25 miles
Active within 5 days
Nice guy looking for same
Hey guys let me tell you a little about myself. I was born in Worcester but I have lived in Boston since 1998, most of the time I have lived in the south end. I own my own companies which keep me busy but I also leave time to have fun :) As for things i like to do, I like to go to the movies, go to the beach, go shopping, hang out with my friends, go dancing, i love to keep busy in the community, there are so many more things i like but you will have to get to know me to learn them. I am 5'11 180 lbs light brown buzz cut hair style, green eyes, medium build I am looking for friends, and of course a B/F. If you like what you have read then send me an email and lets chat.I am looking for a guy who has his life together and knows what he wants in life. I guess someone who is average and normal
Coffee and conversation , Business networking , Dining out , Gardening/Landscaping , Movies/Videos , Music and concerts , Exploring new areas , Nightclubs/Dancing , Shopping/Antiques , Volunteering , Wine tasting
Aerobics, Cycling, Dancing, Hockey, Other types of exercise, Weights / Machines
I exercise 1-2 times per week.
I like Cats, Dogs
Club cafe, 28 Degrees, 647. I also like to take day and weekend trips to other states.
Northeastern University, Boston, MA
I like dance and 80's music. TV shows would be Glee, Desperate House Wifes, The news
Dinner parties with friends, social events, house parties, going to the gym, going out for a cocktail every now and then.
I like to read about gossip and who was seen out and about :)
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'11" (180cms)
|5'9" (175cms) to 6'5" (195cms)
|Body type:
|A few extra pounds
|Slender, About average, Athletic and toned
|Blue, Brown, Green, Hazel
|Light brown
|Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way
|Social Drinker
|Never, Social Drinker, Moderately
|Self-Employed / Entrepreneur
|No preference
I own my own residential and commercial cleaning company in Boston with three employees. I also own an urban landscaping company. I love owning my own business which keep me busy.
|$100,001 to $150,000
|No preference
|Never Married
|Never Married, Widow / Widower, Currently Separated, Divorced
|Have kids:
|No preference
|Wants kids:
|Not sure
|No preference
|White / Caucasian
|White / Caucasian
|Christian / Other
|Agnostic, Christian / Catholic, Christian / LDS, Christian / Protestant, Spiritual but not religious
|Some college
|High school, Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


text:
The DigitalGuys group comprises a class leading Digital Marketing & Advertising Agency, a Creative Design Studio, including Film Production, and a cutting edge Software House. Distinct teams ensures that projects combine expertise from across a range of different skill sets by experts in their fields.
Based in the northwest of the UK, between Blackpool and Preston, the group operates worldwide. We work with both small start-ups right through to blue chip companies and have completed work for a number of diverse clients including both international and national advertising agencies, charities and singer / songwriters.
Working with both national and international brands, we specialise in supplying the best quality large format LED screen technology for both purchase and leasing, amazing promotional Film Production, responsive Websites / Web Design, Motion Graphics, Logos, Branding, Social Media Marketing, CRM & ERP Integration, Bespoke Application Development, iOS, Android & Windows Apps.


text:
TSB Main Page
Some 2011 F-150 vehicles built on or before 4/15/2011 may exhibit a harsh 1-2 shift at or below 24 Km/h (15 MPH), harsh downshifts and/or a flare on upshifts.
Registration is free, easy and gives you access to more features.
If you are not registered, click here
to register.
If you are already registered, you can login here.
If you are already logged in and are seeing this message, your web browser is blocking session
cookies. Change your browser cookie settings to allow session cookies.


text:
YIELD: Makes 6 servings
ACTIVE TIME: 15 min
TOTAL TIME: 30 min
Stir together ricotta, herbs, oil, 1/4 teaspoon salt, and 1 teaspoon pepper in a large shallow serving bowl.
Meanwhile, cook penne in a pasta pot of boiling salted water (3 tablespoons salt for 6 quarts water) until al dente. Reserve 1 cup cooking water, then drain penne.
Stir 1/4 cup cooking water into ricotta mixture, then stir in penne. Thin with additional cooking water if desired and season with salt and pepper.


text:
Wheelhouse Detroit
1340 E. Atwater St.
Detroit Michigan 48207United States
(313) 656-2453
Editor's Review
Located on Detroit's new Riverwalk, Wheelhouse's citywide bicycle tours for all types of riders are addicting and inspiring, too.
On the banks of the Detroit River, in the shadow of General Motors headquarters, there's a small bike shop called Wheelhouse Detroit. In existence for about three years, Wheelhouse is run by Kelli and Karen, two Detroiters passionate about biking and sharing their city's gifts. In addition to a variety of guided tours, Wheelhouse also rents bikes by the hour -- perfect for a leisurely ride along the river. But the real star here are the tours (generally in the $35 range, bike included). The lineup varies month to month, but the schedule usually includes architecture, urban farming (that's the one we took, and it was fascinating), culinary adventures, and family tours. The tours also vary in terms of length and difficulty, but none are very challenging. Detroit is, after all, a fairly flat city. It's safe to say that there is a tour for just about any riding ability. Safety is paramount, and a "sweeper" rides behind to keep tabs on the group and check for any surprise repairs. Bicycles are large, comfortable, and in tip-top condition, providing an interesting way to see the hidden parts of a city that has a whole lot of empty space.


text:
A New York man has been accused of breaking into Sean "Diddy" Combs's East Hampton mansion, where he apparently he ate food, drank liquor and wore the rap mogul's clothes.
The New York Post reports Quamine Taylor of Queens was arrested at the sprawling home on April 1. He's being held in the Suffolk County Jail on trespassing and petit larceny charges.
The unemployed 30-year-old has not posted $2,000 bail.
East Hampton Town Police say they were called to the house after a caretaker found Taylor inside.
A police spokesman didn't immediately return a call on Friday.
In 2010, a Florida woman claiming to be Combs' wife was arrested in East Hampton. Authorities said she was found twice at a home she mistakenly thought was owned by Combs.
Copyright 2015 by Associated Press. All rights reserved.
This material may not be published, broadcast, rewritten or redistributed.


text:
Wednesday, June 15, 2011
© Copyright 2015 Clayton News Daily
By Doug Gorman
The Henry Horsemen improved their record to 2-0 this past weekend with a 31-12 victory against the Georgia Crush.
Relying on big plays from the offense, defense and special teams, the Horseman took the lead early and never looked back, getting point production from those three areas.
"It was a good win for us, but I still don't think we played 60-minutes of football," said Coach Tyrone Barnes. "We sort of let them back in the game in the second half."
It was the Horsemen's home opener at Strong Rock Christian School in Locust Grove.
Horseman quarterback Theo Maxie finished the night 11 of 23 for 128 yards and two touchdowns. He also threw two interceptions.
The Horsemen, a semi-pro football team who play in the Gridiron Developmental Football League, took control of the game early, scoring two first-quarter touchdowns to build a 14-0 lead.
They added a field goal in the second quarter when Derrick Arrington booted a 35 yards field goal in the second quarter.
Tonio Bearden and Andre Powell hauled in the touchdown passes from Maxie en route to the win.
Brandon Shelby finished the game with 60 yards rushing.
The Horsemen also benefited from two touchdowns from the defensive side. De'Mon Glanton returned a 60-yard interception for a score. Reggie Pollard also had a touchdown on defense.
Alvin Cox and Tabaris Johnson led the way with six tackles each.
The Horsemen face their biggest challenge of the year Saturday night when they host the Peach State Rattlers from Warner Robins.
Both teams are undefeated.
The Rattlers rallied last week to beat the Atlanta Aggression 50-26 to keep their two-game record perfect.
"It will be two very good football teams going at it," Barnes said. "We are going to have to play really hard if we want to win."
Kickoff is Saturday at 7 p.m. at Strong Rock Christian. Admission is $10.
More like this story
- Horsemen strike early, roll past Rattlers to stay unbeaten 48-19 ( June 22, 2011 )
- Horsemen beat Jets in battle of unbeatens ( July 20, 2011 )
- Local semi-pro football teams do battle on the gridiron ( July 16, 2011 )
- Horsemen stay unbeaten with fourth win in a row ( June 29, 2011 )
- Local semi-pro football teams do battle on the gridiron ( July 15, 2011 )


text:
Elevated BP May Prematurely Age the Brain »
"Nov. 1, 2012 -- Having even mildly elevated blood pressure at midlife prematurely ages the brain, a new study shows.
Researchers say the early changes seen with higher blood pressure may set the stage for problems with thinking, memor"...
Read the Elevated BP May Prematurely Age the Brain article »
Cardene SR
Cardene SR Consumer
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
COMMON BRAND NAME(S): Cardene SR
USES: Nicardipine is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Nicardipine is called a calcium channel blocker. It works by relaxing blood vessels so blood can flow more easily.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This medication may also be used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. This medication must be taken regularly to be effective. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor. Consult your doctor or pharmacist for details.
HOW TO USE: Take this medication by mouth, usually twice daily with or without food or as directed by your doctor. Swallow the capsules whole. Do not crush, chew, or break the capsules. Doing so can release all of the drug at once and may increase side effects.
The dosage is based on your medical condition and response to treatment. Your doctor may gradually increase your dose. Follow your doctor's instructions carefully.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.
Tell your doctor if your condition persists or worsens (for example, your routine blood pressure readings remain high or increase, your chest pain worsens or is more frequent).
Cardene SR Consumer Overview
Additional Cardene SR Information
Cardene SR - User Reviews
Cardene SR User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Here is a collection of user reviews for the medication Cardene SR sorted by most helpful.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.


text:
Out of Stock
© 2015 Replacements, Ltd. All rights reserved.
With Our "Find This For Me" Service we notify you via email once we have stock!
Piece Code: MAR
Piece Name: Martini Glass
© 2015 Replacements, Ltd. All rights reserved
Piece Code: DOLD
Piece Name: Double Old Fashioned
Piece Code: CHB
Piece Name: Highball Glass
Piece Code: PIT40
Piece Name: 40 Oz Pitcher
Piece Code: CDEC
Piece Name: Decanter & Stopper
Piece Code: CDECNS
Piece Name: Decanter, Missing Stopper
Piece Code: CDECST
Piece Name: Decanter, Stopper Only
Piece Code: CIB
Piece Name: Ice Bucket
Piece Code: CMMS
Piece Name: Small Martini Mixer
Piece Code: CMMSN
Piece Name: Small Martini Mixer, No Lid
Piece Code: CMMSL
Piece Name: Small Martini Mixer, Lid Only


text:
Remove Ads x
Send Ringtone to MobileDownload this Ringtone
We notice you have AdBlock installed. This prevents you from using all features on 4shared. Please consider whitelisting us in AdBlock or click the button below
Click to enable preview
Click to enable preview
senam skj 88 mp3 - download at 4shared. senam skj 88 mp3 is hosted at free file sharing service 4shared.
| Uploaded via: 4shared site
Share Embed Add to my account
Is owner
View only
Upload & Edit
Members may only view items in this folder.
Members may view, add, edit and delete items in this folder.
Checked by McAfee. No virus detected.
10 comments Add new comment View all
Wrong code entered. Please, try again.
Enter the code above to post message:
dinasugiana 1 year ago Reply Spam SpamCancel
bertha ...i miss u....
nardisunar81 2 years ago Reply Spam SpamCancel
matur nuwon yo mas
mdiynziwmtiwo... 2 years ago Reply Spam SpamCancel
kenangan wktu jaman SD
josipramono 2 years ago Reply Spam SpamCancel
hendri_vadim 2 years ago Reply Spam SpamCancel
gila ni skj jaman ane msih sd....jdi nostalgia nih....jman msih kcil emang masa ping bhagia,,,kl udh bsar bnyak yg d pkirin ..
Remove Ads x
senam skj 88 mp3.mp3File QR Code


text:
Buy Tickets NYFF51: Motion Portraits
Show From Series
Friday, July 11
Saturday, July 12
Sunday, July 13
Monday, July 14
Tuesday, July 15
Wednesday, July 16
Thursday, July 17
NYFF51: Motion Portraits
September 28, 2013 – October 11, 2013
Along with political advocacy pieces, cinema verité immersions and historical investigations, portraiture is now a dominant strain in documentary filmmaking. Here are eight vastly different approaches to the form of the cinematic portrait. Read more »


text:
In Theatres
Coming Soon
'This Is Where I Leave You' Movie Review
'The Zero Theorem' Movie Review
Recent Reviews
'Dope' Reads Like A Love-Letter To Nineties Hip-Hop Movies
Al Pacino Is At His Grumpy Old Best In 'Manglehorn'
'Jurassic World' Is Light On Character, But Heavy On Dinosaur-Munching Fun
Andrew Bujalski Cleans Up His Mumblecore Act With Uneven 'Results'
'Spy' Is More Than Just Your Average 'James Bond' Spoof
'Love & Mercy' Shows An Unsunny Side Of The Genius Behind The Beach Boys
'Insidious: Chapter 3' Gets A New Director, But It's Still An 'Insidious' Movie
'Aloft' Gets Grounded By Its Own Artsy-ness
CGI Destruction Overshadows Weak Narrative Foundation In 'San Andreas'
'Aloha' Sets A Schizophrenic Story Against A Beautiful Backdrop
'The Human Centipede III (Final Sequence)' - It's Exactly The Movie That You Think It Is
'Poltergeist' - The Remake Lacks The Heart, The Humor, And The Scares Of The Original
Imaginative Design Can't Save the Dull 'Tomorrowland'
All Films Currently In Theatres
Top Rated Films in Theatres
Review Archive
On Media
New to On Media
'Blended' Is A Tired Mix Of Old Adam Sandler Jokes
Jon Favreau Serves Up Wholesome Entertainment With 'Chef'
'Neighbors' Brings Big Laughs
'The Amazing Spider-Man 2': An Improved Spidey Film Brought Down By A Bad Script
'Belle' Feels Too Safe, Like A Hallmark Movie About British Slavery
'Stage Fright' Pays A Fun Musical Tribute To Classic Hollywood Horror, Both Old And New
'Locke' - The Anti-'Fast And The Furious', It's Minimalist Filmmaking At Its Finest
'Fading Gigolo' Can't Decide Between Being A Romance Or A Comedy, So It Doesn't Do Either Very Well
'The Quiet Ones' Scores Another Hit For Hammer Horror
A Stellar Cast Cannot Save The Dull and Goofy 'Transcendence'
Jude Law Gives A Career Best Performance In The Very Funny 'Dom Hemingway'
'Draft Day' Meanders Between Authentic Portrait And Dramatized Oversimplification
'Oculus' Has All Of The Makings Of A Modern Horror Classic
'Joe' Stars Nicolas Cage In A Very Different Coming Of Age Film
'Under The Skin' Shows A Different Side Of Scarlett Johansson...In More Ways Than One
'Alien Abduction' Is Creatively Clever For A Found-Footage Horror Flick
'Nymphomaniac: Vol. II' Dials Back The Sex, But Increases The Deviance
'Captain America: The Winter Soldier' Showcases Universal Change, With A Weak Character Leading The Charge
'The Raid 2' - More Of The Same, And It's Perfect That Way
'Sabotage': Serviceable Action Mired By A Lazy Script
Try As He Might, Tom Sizemore Can't Even Save '5 Hour Friends'
In 'Bad Words' Jason Bateman Spells Success With A Filthy Mouth And A Solid Cast
All Films Currently On Media
Coming Soon to DVD
Frame of Mind
Recent Posts
Cinema Fearité Bids Farewell To James Horner With One Of His Earliest Works - 'Humanoids from the Deep'
'Fresh Dressed' Tells The Story Of Hip Hop Culture Through Its Fashions
Edinburgh 2015: The Thought-Provoking Future Of 'Index Zero'
Edinburgh 2015: Richard Gere Puts On An Eccentric Show In 'Franny'
Edinburgh 2015: '600 Millas' Is Perfectly Cruel To Its Character, And Viewer
Browse by Tag
Film Review
Touch Of Noir
Independent Film
Cinema Fearite
Rants and Raves
Film Festival
Browse All Tags
Frame of Mind Archive
Movie News
Recent News Posts
Browse by Tag
Browse All Tags
News Archive
Review System
The Twilight Saga: Breaking Dawn, Part One
Kathryn Schroeder
Released: November 18, 2011
Watch Trailer
A chain of events, set off by Edward (Robert Pattinson) and Bella's (Kristen Stewart) marriage, honeymoon and birth of a child, yields a shocking development for Jacob (Taylor Lautner).
Film Review
In the first installment of what will be the final adaptation of Stephanie Meyer's hugely popular "Twilight" series of books,
Breaking Dawn, Part One
finds Edward (Robert Pattinson) and Bella (Kristen Stewart) getting married, and in a freak of nature twist having a human-vampire child.
The film begins on the eve of Bella and Edwards nuptials, as both are struggling with the fact that they will soon be man and wife. Edward feels the need to reveal his one final secret to Bella, a not so shocking story about his lust for blood when he was initially turned and how he preyed on the vermin men of the world--rapists, murderers, and the like. For Bella, this is a time to savor her last days as a human as her future life as Mrs. Edward Cullen will involve being turned into a vampire--something viewers learned in the previous films (books). As Bella walks down the isle surrounded by the beautiful romantic spectacle Alice Cullen (Ashley Greene) has created for their ceremony one cannot help but think Bella is walking towards her death, as she is indeed doing so. The virgin bride of sacrifice, all prettied up in the finest white satin and lace. The wedding is sweet, and somewhat magical to watch, as the chemistry between Stewart's Bella and Pattinson's Edward continues to radiate off the screen in immeasurable proportions. The addition of snappy, humorous, sarcastic dialogue from characters such as Emmett (Kellan Lutz) and Jessica (Anna Kendrick) keep the mood light and fun, and Bella's father Charlie (Billy Burke) delivers his bumbling cluelessness perfectly during his speech. You feel terrible for the man as he just thinks Bella is too young to get married, he has no idea what else is coming her way.
The darkness soon falls over Bella and Edward's happy day when Jacob arrives and, prepare yourself, learns Bella will not be turned into a vampire until after the honeymoon. What!? Edward could kill her with his uncontrollable lust and passion--but he does not. On a tropical island outside of of Brazil Edward and Bella consummate their love in a fury of broken beds and torn feather pillows. All good things come to an end, and for Edward and Bella it is the realization she has become pregnant over the course of a couple weeks in paradise. No one knew it was possible, and no one knows exactly what is growing inside of Bella. An abomination seems to be the general consensus. The audience will find out exactly what Bella has going on inside of her, and in true pro-life support Bella refuses to get rid of the "thing", as Edward refers to it, even as it consumes her, breaking her bones, emaciating her beyond recovery, and quite frankly sucking the life out of her day-by-day.
Breaking Dawn, Part One
is all about the baby, and how it will alter the truce between the Vampires and the Wolves because it is an unknown addition to the balance of their nature. Jacob (Taylor Lautner) becomes an integral part in keeping Bella safe, that is his job it seems over the course of all the films/books, but his journey takes an interesting turn at the end of the film. Bella's child lives, everyone knows that, and Jacob has vowed to kill the child before his wolfpack does the job. Or does he? The film definitely throws a nice twist in to keep the viewer wondering what will happen now with the love triangle of Bella, Edward and Jacob, especially with the baby in the mix.
The entire movie may all be about the baby, but for the first time in
movie history it does make you want to know what will happen next. The story is interesting, if not preposterous at times--when the wolves speak to one another it is more a time to laugh than to be afraid or anxious over what they plan to do to Bella. Not a great deal happens in this first installment after the pregnancy reveal and prior to the birth of the child that is all that exciting, but the brooding, sullen character reactions remain in tact. The time spent waiting for the final moment is worth it for the fans of
, and it is hardly possible anyone who has followed Bella, Jacob, and Edward this far will not be pleased with this first part of the final chapter in their story.
When Director Bill Condon signed on to direct the final
movie, breaking it into two parts, it came as quite a shock. The
films have never been seen as serious pictures, and the direction in the previous three films has been detestable. Condon has directed such acclaimed films as
, he even wrote the screenplay's for
Gods and Monsters
. Condon was not an obvious choice for a
film; it turns out he was the best choice.
Breaking Dawn, Part One
is directed well, even with the sophomoric dialogue and kitschy-ness that plagues all of the
There is an air of maturity now to the themes and characters never seen before; for the first time a strong sense of control is behind the camera. The performances by Stewart, Pattinson, and Lautner are no longer incredibly flat and worthy of eye-rolling when emotional scenes occur. Everyone's timing has improved, and the humor brought by characters actually suits the film rather than hindering it from being a serious movie. Scenes between Edward and Bella are not as stiff as they have been before, and the handling of the love-making scenes is exceptional. As are the scenes of concern, and anger over the child. The final climx when Bella gives birth is done tastefully, while utilizing horror film camera and editing techniques of earlier decades with precisions. Condon envisioned what he thought the final chapter should be like for
and his skill and technique has created a well-directed film. If only he had directed the prior films, it could have saved many a viewer (and critic) hours of pain at the movies.
Drama, Fantasy, Romance
Release Date
November 18, 2011
MPAA Rating
Running Time
117 minutes
Bill Condon
Wyck Godfrey
Stephanie Meyer
Karen Rosenfelt
Melissa Rosenberg
Kristen Stewart (Bella Swan)
Nikki Reed (Rosalie Hale)
Robert Pattinson (Edward Cullen)
Dakota Fanning (Jane)
Anna Kendrick (Jessica Stanley)
Taylor Lautner (Jacob Black)
Kellan Lutz (Emmett Cullen)
Ashley Greene (Alice Cullen)
Michael Sheen (Aro)
Maggie Grace (Irina)
Jackson Rathbone (Jasper Hale)
Billy Burke (Charlie Swan)
Virginia Katz
Guillermo Navarro
Production Designer
Richard Sherman
Casting Director
Debra Zane
Music Score
Carter Burwell
comments powered by Disqus.
blog comments powered by
About Us
© 2008 - 2015 FilmFracture All Rights Reserved.
Web Toolbar by Wibiya


text:
Translator for Comic Book Archive (.cb*)?
Hi there!
Is there anyone interested to work on a Translator for Comic Book Archive files, see Wikipedia?
A Translator sounds nice, but maybe some sort of extraction rule for Expander would do as well. ATM these files open in Expander, but the file listing is empty and no images can be extracted.
Re: Translator for Comic Book Archive (.cb*)?
What coincidence! I have just ported qcomicbook to haiku!
please see:
Re: Translator for Comic Book Archive (.cb*)?
I guess QComicBook works for now (or maybe not based on the comments), but long term we definitely want native apps instead. Looking at the set of features I bet someone could clone this as a native Haiku app in a few weeks, just copying code from ShowImage and Expander.
Or a quicker way would be to make a translator that exposes the various images inside the .cb* files as pages (like for the TIFF translator.) Then you could view them in ShowImage (or other apps) using the page navigation features (which are mostly unused except for TIFFs.) That might work pretty well in fact. Then we just need to add some of the other niceties to ShowImage, like the thumbnails (which has certainly been in the back of my mind for a while.) But honestly that is getting into R2 territory.


text:
As above
great product
Very good service. Goods came within the week,
Well-made product
Love this! Best brush ever, use on all my clients
Brilliant colour and brilliant brush
On my 3rd tangle teezer best hairbrush
Its amazing as it brushes easily even through my thick hair, and unlike other brushes doesnt leave it static
Great quality
it does the job
Fantastic product!! I will not go back to standard brush
I bought this for my daughter's knotty hair and it is amazing. Even on wet hair, just one comb gets the knots out. Also tried it on my hair - fantastic. Why didn't I get one sooner?
Abdutely pointless product. Doesn't go what it promises. Just a bunch of false marketing statements and attractive colours, but when it comes to the job it is useless. Basically, stick to the conventional brush!
Ratings Guide Read about our product rating system


text:
The Best Blogger Craft Ideas 2015: Home Decor Ideas, DIY Jewelry, Easy Crochet Patterns and More
Bonus: Get our newsletter & special offers for free. We will not share or sell your email address. View our Privacy Policy
T Shirt Hanging Wall Art
By: STYROFOAM* Brand Foam
We are adding the craft to your Craft Projects.
The project was added to your Craft Projects.
Click here to view your Craft Projects.
A creative and crafty idea; turn old t-shirts into delightful posters! This project can be completed in less than one hour.
- STYROFOAM™ Brand Foam:
- Sheets: One, 12" x 36" x 1" sheet OR three 12" x 12" x 1" squares
- Disc: 12" x 1"
- Four junior T-shirts, size large
- Thick, white craft glue
- Straight pins
- Scissors
- Sawtooth picture hangers: four OR poster putty
- Optional: If using 12" x 36" x 1" sheets, additional supplies include ruler, pencil, serrated knife, old candle, dental floss
1. If using 12" x 12" x 1" squares, skip to Step #2. Using ruler and pencil, score foam sheet to create three, 12" x 12" squares. Wax serrated knife with an old candle. Holding foam sheet firmly on a flat surface, extend one end and cut across the score line, using knife like a saw. Or, try dental floss: Stand the sheet on its edge and hold a 20" length of dental floss along the scored line, positioning one hand at the bottom of the board and the other at the top; draw the dental floss down through the foam sheet along the scored line. Cut three 12" x 12" squares.
2. Insert 12" x 12" foam square into t-shirt. Carefully position foam square so that t-shirt design is centered and seams are not in front. Test "fit" of t-shirt: stretch t-shirt fabric over edges, being sure that sleeves and neckline can be stretched over the sides to the back. Carefully trim away back side of t-shirt and excess fabric, leaving several inches all around to cover edges.
3. Wrap foam square in t-shirt fabric, neatly folding fabric at the corners. Pin and glue fabric to reverse side.
4. Following Steps 2 & 3 above, cover foam disc with t-shirt.
5. Glue sawtooth picture hanger to back. For additional hold, insert and glue two straight pins through holes in sawtooth picture hanger. Or, attach foam squares to wall with poster putty.
6. Let dry before hanging.
Tags / Related Topics
Your Recently Viewed Projects
Images from other crafters
Love these projects? Get MORE delivered to your Inbox – FREE Click Here!
Jan 09, 2010
When anyone has gone on vacation they have always brought back t-shirts for my, now pre-teen and young teenage, granddaughters. This is a great way to preserve the ones they can't bear to part with, but no longer fit.
- WAS THIS HELPFUL? YesNo
Crafter 4846706
Jan 04, 2010
love this idea. im gonna do this with my husbands harley shirts for our game room. thanks
- WAS THIS HELPFUL? YesNo
Crafter 20503
Oct 06, 2009
awesome! I am in process of making Tshirt quilt..to many tshirts this will help use the extras.. thank you
- WAS THIS HELPFUL? YesNo
Report Inappropriate Comment
Are you sure you would like to report this comment? It will be flagged for our moderators to take action.
Thank you for taking the time to improve the content on our site.
What's Hot
- 20 Mini Handmade Craft Ideas
- Scrap Fabric Birds
- Crafting on a Budget: Low Cost Craft Projects
- 36 Dollar Store Crafts and Cheap Gift Ideas
- "Cheap and Easy Crafts" Free eBook
- "24 Handmade Craft Ideas from 2010: A Year of Free Crafts" eBook
- Top 10 Christian Crafts
- T Shirt Hanging Wall Art
- Knit Cap Upcycled Pillows
- "31 Cupcake Inspired Creations eBook"
Something worth saving?
- SAVE all your favorite crafts
- ADD personal notes
- QUICKLY reference your crafts
Free eBooks
- 14 Toilet Paper Roll Craft Ideas
- 23 Fabulous Picnic Craft Ideas + Restaurant Copycat Recipes
- 4th of July Crafts and Recipes
- 4th of July Crafts: Blogger Edition 2010
- Crafts for Father's Day: 36 Homemade Father's Day Gift Ideas
- Garden Crafts
- Graduation Crafts
- How To Make Tie Dye Shirts, Decor & More: 18 Tie Dye Patterns
- The Best Blogger Craft Ideas 2015: Home Decor Ideas, DIY Jewelry, Easy Crochet Patterns and More
Our Newest Projects & Articles
- 12 Days of Christmas in July Giveaway
- Houndstooth Wallpaper Stencil
- Quilted Paper DIY Wall Art
- Sweet Decoupage Picture Frame
- Super Simple Painted DIY Wall Art
- Scrap Fabric Hair Accessories
- Metal Stamped Floral Stakes
- Ultimate Plaid Home Decor Assortment
- 9 Free Knitting Patterns for Accessories
- Grab & Go Organizer


text:
Such and such a time, such and such a day, then trouble with the valve.
People with valve problems develop heart murmurs and may eventually need valve replacement.
When he finally opened the valve, he says, the team was able to cool the core for the first time since the crisis began.
late 14c., "one of the halves of a folding door," from Latin valva "section of a folding or revolving door," literally "that which turns," related to volvere "to roll" (see volvox). Sense extended 1610s to "membranous fold regulating flow of bodily fluids;" 1650s to "mechanical device that works like a valve;" and 1660s in zoology to "halves of a hinged shell."
valve (vālv)
A membranous structure in a hollow organ or passage, as in an artery or a vein, that folds or closes to prevent the return flow of the body fluid passing through it.
Any of various devices that regulate the flow of gases, liquids, or loose materials through piping or through apertures by opening, closing, or obstructing ports or passageways.
The movable control element of such a device.
UK term for a vacuum tube.


text: The 2013 District 8 Holstein Show will be held Saturday, Aug. 3 at 10:30 a.m. at the Stearns County Fairgrounds in Sauk Centre. Adam Johnson, Holstein breeder from Pelican Rapids, Minnesota is the judge. The show will be held with the Stearns County Fair Open Class Dairy Show. Exhibitors will be fro...Read More


text:
A Superior Blended Scottish Wihisky< read all 1 reviews
I would like to introduce what is without a doubt one of the finest Scotch Whisky blends.Johnnie Walker Gold Label – The Centenary Blend
A slightly punky peaty smell is accented by intense floral notes. Seaweed and traces of iodine float in a mildly fruity sea pond, with a nice soft pop of cherry in the background. A little oil in the glass adds legs and helps the nose achieve a certain harmony. …..
Read the full review here..
Review: Johnnie Walker Gold Label
I have heard certain purists and intellectual whisky snobs bash the blends. In my opinion, it is a blended whisky like Johnnie Walker Gold Label that proves just how glorious a the blended category can be.
What did you think of this review?
Use Trust Points to see how much you can rely on this review.


text:
Latest Aaron Craft Leads
17 Dec 13
The Jason McIntyre Show: Matt Norlander and Jeff Borzello of CBS Sports Talk College Basketball
Syracuse? Kansas? Arizona? We talked about a teams. Not Duke, though.
04 Dec 13
The Jason McIntyre Show: Jay Williams on Training Camp with Jason Kidd and Lawrence Frank. Also, College Basketball
I love Aaron Craft more than Jay Williams does.
25 Nov 13
Roundup: Aaron Murray Tears ACL, Gerald Green Soars & Miley Cyrus and a Cat at the American Music Awards
Manning and Brady keep you up late?


text:
Originally written on Jocks and Stiletto Jill | Last updated 1/16/13
Raptors rookie Terrence Ross only had four points in Tuesday night's match up against the Brooklyn Nets. But the reverse putback dunk that was responsible for a pair of those points, was a thing of beauty. Whose in this year's dunk contest? Gerald Green? Paul George? WOuld Terrence Ross be someone you want to see on the "All-Star Saturday Night" stage? video via NBA
Comments are closed.
What do you think?To leave a comment, you can:
NBA News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
Follow us on Twitter
|Best of Yardbarker
|NFL News
|MLB News
Today's Best Stuff
For Bloggers
Join the Yardbarker Network for more promotion, traffic, and money.
Company Info
What is Yardbarker?
Yardbarker is the largest network of sports blogs and pro athlete blogs on the web. This site is the hub of the Yardbarker Network, where our editors and algorithms curate the best sports content from our network and beyond.
|© 2015 Yardbarker, Inc. All rights reserved. Use of this website (including any and all parts and components) constitutes your acceptance of these Terms of Use and Privacy Policy. (What's New?)


text:
|The EFA 2000 Assessment: Country Reports
Next Page
PART 1: Descriptive section
Brief Description of Review Process
This country report is a product of collaborative efforts involving policy makers, planners and researchers from Federal, State and Local Government, education authorities as well as parastatals of the Federal Ministry of Education with responsibilities for various aspects of basic education (eg. mass literacy, teacher education, nomadic education, curriculum development), professional teachers associations, NGOs and other stakeholders in the promotion and delivery of basic education such as Permanent Teachers Associations, International Organisations, i.e. UNICEF, UNDP, UNESCO which make up the National Basic Education Steering Committee. The latter evolved from the EFA National Task Force and is now constituted into the National EFA Assessment Committee, with members with relevant expertise constituted into the Technical sub-group.
The current review follows up on the mid-term Review carried out in 1995 using the guidelines provided by the EFA Forum Secretariat. Thus the Review draws information from the outcome of data gathering on quantitative and qualitative information needed to assess the progress made in each of the six target dimensions of the Jomtien Conference. The outcome of the two day Mid-Decade Review Seminar on EFA during which Federal, State, LGEAS and other stakeholders gave progress reports, appraised progress made in the different sub-sectors of basic education in groups and made suggestions for the improvement of the strategies being adopted, as well as Reports of achievements made thereafter by the different groups.
The report also draws from Evaluation Reports such as:
(3) The Comprehensive Education Analysis Project in September 1999
Furthermore, the Report draws on the work of the Technical sub-group of the EFA Assessment Group, which considered the 18 indicators recommended to guide the preparation of the current report with a view to determining on which of the data is available. It decided to carry out a survey which will identify data in areas in which they are not available and to use them when obtained along with existing data and analyse them in the course of the Comprehensive Education Analysis project in the country. Although a formal forum was not organized to debate the Report, components of it were considered at other various fora.
Background Information
Nigeria: A Country Profile
Land Area :923,768 sq. km
Population (1998):108.2 million
Population density (1990-1992):04 persons per square kilometre
Population distribution (1998) Urban 36%
Rural - 64%
Under one year pop.-2.5 million
Under five years pop.- 17.1 million
Six-Eleven years pop.-19.34 million
Population growth rate2.83%
Administrative divisions
Nigeria is a federation of 36 States and a Federal Capital Territory.
There are3 types of Governments; the Federal, State and Local
Governments. Following the successful completion of the transition to Civil
Rule programme with effect from 29 May 1999, each State is governed by an
elected Governor, while each local government is headed by an elected
Chairman who is the Chief Executive assisted by a Secretary who is the
administrative head.
Duration of Compulsory Education9 years
Adult Literacy Rate (1995) Female-47.3%
Male - 67.3%
School Age Population (1995)18.2 million
Primary School Enrolment (1995) Girls-7,011,657
Primary School Completion (1995)Girls-68.2%
As % of total enrolmentBoys-70.6%
Number of primary schools 41 531
Number of primary school teachers437,619
Male - 230,287
Average teacher-pupil ratio1:36
Sources:(a) Federal Ministry of Education
(b)National Population Commission.
Jomtien was not for Nigeria the beginning of the journey towards universalising education. It dates back to the introduction of universal primary education in the 1950s in two of the then three regions of the country and its introduction at the national level in 1976. Thus, by joining other countries, agencies and organisations in adopting in March, 1990 the World Declaration on Education For All, Nigeria was merely reaffirming that in which she believed, and had already taken steps towards its attainment.
The National Policy on Education, (1977, revised 1981, 1985, 1998) attests to Nigerias commitment to Education For All, in particular, basic education for all. The policy lays emphasis on universal, functional and qualitative education.
The guiding principle of the Education For All programmme in Nigeria is the equipping of every citizen with such knowledge, skills, attitudes and values as will enable him/her to derive maximum benefits from his membership of society, lead a fulfilling life, and contribute his own quota towards the development and welfare of the community.
For Nigeria therefore, Basic Education comprises both the range of formal schooling as well as a wide variety of non-formal and formal public and private educational activities offered to meet the learning needs of groups of people of all ages. Thus basic education refers to early childhood and pre-primary education, primary education, the first three years of secondary education and basic and functional literacy for out of school children, youth and adults, as well as nomadic education for school age children of nomads and migrant fishermen.
EFA Goals and Targets
Not long after the Jomtien Conference, Nigeria took specific measures aimed at translating the Jomtien Declaration on Education For All into reality. The activities embarked upon included a sensitization drive mounted not only in the mass media, but also through the agency of the two key national advisory bodies on education policy, namely, the Joint Consultative Council on Education which brings together various officials in Federal and State Ministries of Education, and the National Council of Education which is composed of State Commissioners of Education and the Federal Minister.
The discussions and consultations of these meetings resulted in a clear perspective of what State and Federal Government priorities were within the context of basic education and a sharper focus was obtained as to what remedies were considered most urgent. Using the resulting information, a national plan of action on Education For All was drawn up. A Task Force (which metamorphosed into the present EFA Assessment Group) was set up to coordinate all activities related to EFA.
The Master Plan articulates the EFA goals and targets in all dimensions including the six target dimensions recommended in the EFA Assessment Guidelines.
The goals and targets on the various aspects of basic education as follow:
Formal education begins from pre-primary education which is the education given in day-care centres and Nursery schools to children aged 3 to under 6 years. It is enriched by the informal traditional up-bringing given to children from 0 to under 3 years which makes them ready for school. Although Government is not directly involved in the establishment of day-care centres and nursery schools, it is however responsible for:
According to the National Policy on Education, the purpose of pre-primary education are to:
In consonance with the Jomtien Declaration, World Summit for Children, the Convention on rights of the child, ECCDE has become an important part of basic education programme. This has provided supportive policy implications for different sectors such as health, social services, agriculture, nutrition among others. Furthermore, the Convention on the Rights of the Child led to the setting up of implementation committees that have harmonized national laws and policies.
As a practical demonstration of governments commitments to children, the Federal Government in co-operation with UNICEF instituted a project on Early Childhood Care Development Education (ECCDE) which draws great strength from the concept that life begins at birth; the project took off in 1991. The project goals are to:
These goals are in accord with the EFA Master Plan that seeks to:
Concerning early child care, available statistics from a sample survey conducted in 1991 revealed that only 4.7% of the pre-school age population had pre-primary education in Nigeria. Today, the situation is different owing to the rapid expansion of the ECCDE project.
|Next Page


text:
October 16, 2012
These bloody bandaid cookies are not for the faint of heart. The cookies, made by Scoochmaroo, are disgustingly designed to look like a dirty plaster, with its puffy marshmallow gauze and red dye blood over top a graham cracker. They're the perfect treat to serve up to guests this Halloween with a simple how-to.
If you're feeling a bit more adventurous in the kitchen, try out these blood slide suckers.
Image Sources:
Related Articles
- Gluten Free Stuffed Mushrooms 3 Ways
- Spooky Savory Gluten Free Halloween Treats!
- Halloween Cupcake Toppers Are Gruesomely Gory Gumpaste
- Halloween Popcorn is a Candy Corn Confection
- Hassel-Free Pumpkin Cheesecake Recipe
- 5 Best Gluten Free Pumpkin Cheesecake Recipes
- Follow a Liquid Diet this Thanksgiving with Drinkable Apple Pie
- 3 Awesome Pumpkin DIY Projects
- Cupcake Stuffing is a Basting Baker's Ideal Thanksgiving Feast
- Easy Entertaining: 3 Must-Try Gluten Free Appetizers
Related Recipes
Want more from Foodista? Sign up below!


text:
Welcome to Tesco Wine by the case.
We hope you enjoy your visit.
Use the options on the left to narrow your search further, or to widen your search, you can remove the selected options from the list above.
Showing products 1 - 3 of 3
previous page
next page
Special Offer - 50% off
"If you need a party Champagne, look no further. It is here! Andre Carpentier Champagne is a classic ..." more about André Carpentier Champagne Brut
Was £161.94 per case
Now £80.94 per case
Equivalent to £13.49 per bottle
You save £81.00 per case
80 Clubcard Points
"If you love Cava with a bit of sweetness, this one from family producers Freixenet is just the ticke..." more about Freixenet Cordon Oro Cava 75cl
£59.94 per case
Equivalent to £9.99 per bottle
59 Clubcard Points
"A lively, refreshing wine full of bright candied fruit flavours with background floral notes."
£77.94 per case
Equivalent to £12.99 per bottle
77 Clubcard Points
Showing products 1 - 3 of 3
previous page
next page


text:
Amazon looks to expand delivery beyond home, office
Jul 31, 2012
The online retailer hopes 'locker' program will broaden its customer base.
Amazon's Bezos donates $2.5 million to support same-sex marriage
Jul 27, 2012
Why support for gay rights is also a shrewd tactical move in the tech community.
Why companies take political, social stands
Interview by
Jul 27, 2012
There's a lot of buzz this morning about Amazon.com CEO Jeff Bezos's decision to give $2.5 million to support a referendum that would legalize same-sex marriage. Meanwhile, Southern politicians have declared next Wednesday "Chick-Fil-A Appreciation Day" after the fast-food chain's president emphatically declared his opposition to gay marriage.
Why is Amazon becoming a hardware company?
Jul 24, 2012
Don't be fooled: All the new tablets Amazon has on the horizon are just shopping carts in disguise.
Support grows for online sales tax
Jul 17, 2012
Republican governors and giant e-commerce retailer Amazon now back Congressional legislation to tax online transactions.
Competition heads for the cloud
Jul 2, 2012
After a vicious storm knocks out some cloud computing services, competitors look to profit.
Storms hit Amazon data center, Netflix and Instagram
Jul 2, 2012
Amazon's servers were hit by a storm in Virginia. Those data centers are also home to storage for other major websites like Netflix, Pinterest and Instagram.
Facebook is spending $60 million to recognize your face
Jun 20, 2012
The social giant bets big on facial recognition software, but what is it using that information for?
Greenpeace says Apple and Amazon have dirty clouds
Apr 19, 2012
Greenpeace says some companies running cloud services are doing better than others from an environmental stewardship point of view. It gives Amazon and Apple Fs. Plus, "The Legend of Grimrock" shows you the fun to be had while trapped in a dungeon.
Amazon acquires rights to James Bond novels
Apr 18, 2012
Amazon is stepping up its publishing push, with help from none other than Agent 007. The online bookseller has just acquired the rights to the James Bond novels behind the movies.


text:
Attention high school students: what are your plans for the fall? Plan on Northern Essex! Come to an Info Session on June 24 or July 14 to learn more.
Now is a great time to register for fall courses. Whether you want to attend classes days, evenings, weekends, or online, NECC offers classes at a time that is convenient for you! Learn more.
With seven patents and 32 years in the engineering field, Jim Cahaly has a hands-on kind of knowledge that he easily shares with his engineering students....Read More »


text:
|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | Lounge | The Wire | Audio | Arcade
Big Bad Booty Daddy
Join Date: Sep 2003
Location: New York
Posts: 20,674
Rep Power: 200000
Points: 2,502,105,014,390.44
Bank: 0.00
Total Points: 2,502,105,014,390.44
Comments Thread For: Escobedo Ready To Return, Faces Cherry in Atlantic City
Junior lightweight contender Vicente Escobedo will fight Edner Cherry in a scheduled 10 round bout at the Boardwalk Hall in Atlantic City, NJ on Saturday night.
Golden Boy Promotions matchmaker Eric Gomez advised Boxingscene.com on Sunday that the bout will not be televised on HBO.
The World Championship Boxing telecast was originally to show Adrien Broners lightweight world title belt defense against Welshman Gavin Rees along with the rematch between heavyweights Jonathan Banks and Seth Mitchell. [Click Here To Read More]
Up and Comer
Join Date: Mar 2012
Posts: 52
Rep Power: 4
Points: 2,176.20
Bank: 0.00
Total Points: 2,176.20
Escobedo-cherry will be a better fight than Broner-Rees. Why wouldn't they air it? smh
Join Date: Nov 2012
Posts: 382
Rep Power: 0
Points: 7,239.48
Bank: 0.00
Total Points: 7,239.48
****in' Cherry-picker
Undisputed Champion
Join Date: Mar 2011
Posts: 5,213
Rep Power: 16
Points: 53,092.44
Bank: 0.00
Total Points: 53,092.44
Cherry's a VG boxwr but his management,IMO, ruined his career by insisting he fight @ 135-144 & kept him in tampa area way 2 far... Remeber he lost badly 2 Bradley...not a big puncher but technically very sound...2 bad a good fight 4 him comes late...he hasn't much left
|Share This With Friends
|Thread Tools
Privacy Policy - Submit
News - Feedback
- Site Map - Advertise
with Us
Copyright © 2003-2014 BoxingScene LLC All rights reserved.
Copyright © 2003-2014 BoxingScene LLC All rights reserved.


text:
Thu., March 26, 2015 11:44am
New UGA Law School Program Focuses On Environmental Law
The university says Georgia Sea Grant is partnering with UGA's Carl Vinson Institute of Government to create the new Georgia Sea Grant Legal Program.
Full Story
Tue., March 24, 2015 12:14pm
UGA To Host Summit On Food Insecurity, Food Waste
The Campus Kitchens Project and the Food Recovery Network are scheduled to hold a summit at UGA April 18 and 19 at the Zell B. Miller Learning Center.
Thu., January 22, 2015 6:05pm
Georgia Football Coach Richt Gets 2-Year Contract Extension
Georgia football coach Mark Richt has received a two-year contract extension that ties him to the Bulldogs through 2019 and increases his salary to $4 million a year.
Sun., January 4, 2015 11:21pm
University Of Georgia To Host State Ballet Theatre Of Russia
UGA said in a news release that the company of 50 dancers will perform "Swan Lake" at the school's Performing Arts Center Jan. 13 and 14.
Mon., December 29, 2014 11:13am
Last Trainload Of Coal Marks End Of Era At UGA
This University of Georgia is marking a milestone this week, as the last scheduled shipment of coal is expected to arrive by train.
Tue., December 2, 2014 4:57pm
Demonstration Planned In Athens Over Ferguson Case
The University of Georgia NAACP and the UGA Office of Student Affairs Multicultural Services and Programs are organizing what's described as a peaceful vigil and march in honor of Michael Brown, who was shot by police in Ferguson, Missouri.
Mon., August 25, 2014 2:51pm
Why Are Southerners So Passionate About Football?
Why are Southerners so passionate about football? From Friday night lights to college championships to the Superbowl, people in the South love their pigskin. This week, we're looking at why.
Friday, August 29, All Things Considered will broadcast from Peachtree Ridge High School in Suwanee. Legendary University of Georgia football coach Vince Dooley joins host Rickey Bevington to talk about growing up in southern football culture, leading the winningest team in bulldogs history and his predictions for the future of the game.
Tue., June 3, 2014 12:54pm
Georgia Sports Media Get A First Look At 2014 College Football
Georgia's sports reporters got a closer look at the upcoming college football season at the annual Pigskin Preview event at the Georgia Sports Hall of Fame in Macon Tuesday. Mercer Bears head coach Bobby Lamb was on hand to talk about the changes to his program just up the hill from the Sports Hall. "I think the biggest challenge for us is going into the Southern Conference. Certainly the speed of the conference will be a lot different than what we played last year," Lamb said. Mercer finished with a 10-2 record in the Pioneer League last year in what was the team's debut season. They head into Southern Conference play with their 2013 roster plus some new transfers and some freshmen.
Fri., March 14, 2014 2:41pm
UGA Prof: Rising Sea Levels Will Bring More Floods to Coastal Communities
Dr. Charles Hopkinson says sea-level rise is likely to mean increasing flooding.
Wed., December 4, 2013 1:00pm
50 Years of Dooley: Coach 'Proud' Of Tenure
Looking back, Vince Dooley never expected to last at the University of Georgia. "To my wife Barbara, I said, 'Don't get too comfortable. Don't unpack! We may not be here very long, which is the nature of the business, but I'm going to give it my best shot,'" Dooley said in an interview Wednesday with GPB.
©Copyright 2015, Georgia Public Broadcasting. All Rights Reserved
Georgia Public Radio®


text:
253 Coulter Building
239 Memorial Drive
Cullowhee, NC 28723
828.227.7242 tel
828.227.7162 fax
NEWSCollegium Music Workshop to present July 2 recital at Cullowhee Baptist Church
WCU student receives Sigma Alpha Iota scholarship
May 5 concert to feature trumpeters from two WCUs
WCU music students give WNC school children a taste of opera
April 24 show 'can't come fast enough' for WCU alumna Jeanne Jolly
School of Music
Welcome to the Western Carolina University School of Music, where music makes a difference in your learning and your life. Our faculty of performing artists is dedicated to developing the next generation of musicians, performers, and educators.
All music degree programs require the performance of a live audition. Audition dates for Fall 2016 are:
- Saturday, February 20, 2016
- Saturday, March 5, 2016
Degree Programs in Music
- Music (B.A.)
- Music Industry (B.A.)
- Music Education (B.M./B.S.Ed.)
- Music, Commercial & Electronic (B.M.)
- Music Performance (B.M.)
A message from the Director of the School of Music.Studio Links:


text:
Tuesday, November 23rd, 2004
Are you a sound fanatic? Do you have your computer hooked up for surround sound or at least have multiple speakers? Well, if you tell Windows about your sound configuration, you'll probably enjoy your speakers even more. Here's how:
1. Click the Start button, Control Panel , then open the Sounds & Audio Devices icon.
2. Under the Audio tab, click the Advanced button… Continue reading