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Software-as-a-service offers cost savings, scalability and mobile accessibility -- if you correctly manage the resulting SLAs, APIs and data structures.
Methods of Malware Persistence on OS X Mavericks
As Mac OS X continues to increase in popularity, OS X malware, once a rare phenomenon, is now more common than ever. Due to this, it is essential for forensic and malware analysts to possess an in-depth understanding of OS X and how it may be attacked by malicious code.
Provided By SecurityTube.net
Hacking the Oracle Application Framework: A Case Study in Deep-Dive Pen Testing
The Oracle Application Framework (OAF) is the base of dozens of Oracle's web-based business applications (the e-business suite) and is used by many other organizations to develop their own in-house applications. Last year, the speaker published a major vulnerability (CVE-2013-xxxx) in the framework that allowed inspect inspection of run-time data.
Provided By SecurityTube.net
Building Your Application Security Data Hub: The Imperative for Structured Vulnerability Information
One of the reasons application security is so challenging to address is that it spans multiple teams within an organization. Development teams build software, security testing teams find vulnerabilities, security operations staff manage applications in production and IT audit organizations make sure that the resulting software meets compliance and governance...
Provided By SecurityTube.net
IEEE Computer Society's Center for Secure Design: Helping You Design More Secure Software
The IEEE computer society's CSD (Center for Secure Design) was formed in 2014 with the goal of identifying common design flaws and creating tools or design patterns so architects and developers can avoid introducing those design flaws into software. The CSD aims to create artifacts to aid in the analysis...
Provided By SecurityTube.net
Warning Ahead: Security Storms are Brewing in Your JavaScript
JavaScript controls the peoples' lives - they use it to zoom in and out of a map, to automatically schedule doctor appointments and to play online games. But have they ever properly considered the security state of this scripting language? Before dismissing the (in) security posture of JavaScript on the...
Provided By SecurityTube.net
Stop Chasing Vulnerabilities - Introducing Continuous Application Security
For too long, application security has been \"Experts-only\" and practiced one-app-at-a-time. But modern software development, both technology and process, is mostly incompatible with this old approach and legacy appsec tools. Software development has been transformed by practices like continuous integration and continuous integration, and the time has come to bring...
Provided By SecurityTube.net
Reversing Engineering a Web Application - For Fun, Behavior and WAF Detection
Screening HTTP traffic can be something really tricky and attacks to applications are becoming increasingly complex day-by-day. By analyzing thousands upon thousands of infections, the speaker noticed that regular blacklisting is increasingly failing and started research on a new approach to mitigate the problem. Initially reverse engineering the most popular...
Provided By SecurityTube.net
From the Ground Up
In this podcast, the speaker will explain about the continuation of that proof and is aimed at developers to help them detect security vulnerabilities using live source-sink analysis. It is dependent on the code coverage and not aimed to be used in a production environment.
Provided By SecurityTube.net
Ground Truths of a Rugged DevOps Practitioner
In this podcast, the speaker will explain about the rugged DevOps practitioner. DevOps is an emerging set of principles, methods and practices for communication, collaboration and integration between software development (application/software engineering) and IT operations (system administration/infrastructure) professionals.
Provided By SecurityTube.net
The DevOps of Everything
Although the movement started out as a problem statement to solve developer and operations collaboration, it quickly moved into other disciplines such as security, networking and storage. In this podcast, the speaker will take a look at the DevOps affect on things like converged infrastructure, software defined networking, software defined...
Provided By SecurityTube.net
Where the Security Rubber Meets the DevOps Road
DevOps is a natural evolution of agile, lean, continuous integration and other patterns common amongst high performers and continuous process improvement. As someone who has helped dozens of organizations get started with DevOps patterns and tool chains, in this podcast, the speaker will explain where people get started - and...
Provided By SecurityTube.net
Runtime Manipulation of Android and iOS Applications
With over 1.6 million applications in the Apple AppStore and Google Play store, and around 7 billion mobile subscribers in the world, mobile application security has been shoved into the forefront of many organizations. Mobile application security encompasses many facets of security. Device security, application security, and network security all...
Provided By SecurityTube.net
Use After Free Exploitation
Use after free vulnerabilities is the cause of a large number of web browser and client-side compromises. Software bugs residing on the heap can be difficult to detect through standard debugging and QA. In this podcast, the speaker will first define the use after free vulnerability class, and then dive...
Provided By SecurityTube.net
HP 3PAR StoreServ Chalk Talk (HP Discover EMEA December 2013 update)
Learn about the December 2013 updates to the HP 3PAR StoreServ portfolio in this lastest HP Storage ChalkTalk from HPStorageGuy Calvin Zito. Sponsored by HP and Intel® Xeon® Processor : Intel, the Intel logo, Xeon, and Xeon Inside are trademarks or registered...
Provided By HP & Intel® Xeon® Processor
TechViews - Deconstructing DevOps
The TechViews programs will help to cut through the noise of the market and bring you real insights from thought leaders across the industry. 15 minute podcast on DevOps - What is it? Why use it? Listen now.
Provided By CA Technologies
AIG Podcast
Learn how AIG's Global Performance Architecture Group improved the performance of their services to deliver better experiences and payoffs for businesses and end-users alike. HP is the sponsor of this material. By submitting your information you agree to be contacted by HP on topics of interest. Before deciding please...
Provided By Hewlett-Packard (HP)
T-Mobile Podcast
Learn how wireless services provider T-Mobile US, Inc. improved cloud- and data-access services delivery to its enterprise customers. Listen to the podcast featuring Daniel Spurling, Director of IT Infrastructure at T-Mobile US, Inc and understand now T-Mobile moved from manual cloud provisioning services to a centralized service portal to better...
Provided By Hewlett-Packard (HP)
Unum Group DevOps Podcast
Listen to the podcast on how employee benefits provider Unum Group has been building a DevOps continuum, and is further exploring the benefits of a better process around cloud-assisted applications development and deployment. Featured on the podcast are Tim Durgan, an Enterprise Application Architect at Unum Group, and Petri Maanonen,...
Provided By Hewlett-Packard (HP)
McKesson Cloud Automation Podcast
Download the podcast on how McKesson accomplished a multi-year, pan-IT management transformation. Learn how McKesson's performance journey, from 2005 to the present, has enabled it to better leverage an agile, hybrid cloud model. How McKesson gained a standardized services orientation to achieve agility in deploying its many active applications is...
Provided By Hewlett-Packard (HP)
Thinking ahead: Pragmatic steps for successful cloud transformations virtual event
Public, private, or hybrid, the cloud is creating an array of opportunities for business and IT. And it's reshaping IT as we know it. But incorporating cloud technology and services into the data center can entail multi-year transformations. The key to successful cloud transformations is developing a pragmatic strategy and...
Provided By Hewlett-Packard (HP)
Stepping Into the Cloud: A Practical Guide to Launching a Successful Cloud Strategy
Frost & Sullivan's video "Stepping into the Cloud: A Practical Guide to Creating and Implementing a Successful Cloud Strategy" offers practical guidance for migrating your company to the cloud -- at your own pace and on your own schedule. Take the first step today.
Provided By IBM
Building A Successful Roadmap to Cloud
To get the most from your cloud experience, you need a roadmap. Watch the video "Building a Successful Roadmap to the Cloud" to learn how a cloud roadmap can: Ensure that your cloud decisions work together to maximize the overall value to your business Give you greater...
Provided By IBM
There's Gold in Them Thar Package Management Database
There is a lot of useful file metadata stored in package management databases for popular Linux distributions. The RedHat Package Manager (RPM) and Debian's dpkg are two examples. In this podcast, the speaker focus on how to leverage RPM in forensic investigations, as it can provide a quick and effective...
Provided By SecurityTube.net
Android AddJavaScript Exploit
In this podcast, the speaker demonstrates the vulnerability that can be exploited due to a cross site scripting in web views JavaScript bridges. This vulnerability allows an attacker to run system commands using Java's reflection mechanism. The vulnerability lies in the fact that JavaScript can access Java objects using the...
Provided By SecurityTube.net
Hacking with Python 3 - Zip Password Cracker
In this podcast, the speaker explains about how to crack ZIP password using python script. This speaker also teaches the user how to create their own tool using python programming language.
Provided By SecurityTube.net
Use Cobalt Strike's Payloads with Veil's Evasion
The Veil framework is a collection of red team tools, focused on evading detection. In this podcast, the speaker shows how to use Veil Evasion to generate an anti-virus safe payload that delivers Cobalt Strike's Beacon payload. The method allows Veil to take advantage of Cobalt Strike's custom shellcode to...
Provided By SecurityTube.net
OWASP PHP Security
OWASP PHP security project is an effort by a group of PHP developers in securing PHP web applications, using a collection of decoupled flexible secure PHP libraries, as well as a collection of PHP tools.
Provided By SecurityTube.net
Reverse Engg and Identifying Buffer Overflows
In this podcast, the speaker will show a reverse engg an executable, identifying an insecure function and identifying if that can be reached by a user input. The speaker also explains the use of static and dynamic reverse engg tricks to identify memory corruptions issues.
Provided By SecurityTube.net
Network World: Productivity Software - The Next Generation
In this podcast, the speaker explains about the network world productivity software. The speaker also explains about the new batch of wikis, blogs, and other collaborative software that helps companies become more productive and deliver value.
Provided By Novell
Application Security at DevOps Speed and Portfolio Scale
Software development is moving much faster than application security with new platforms, languages, frameworks, paradigms, and methodologies like agile and Devops. Unfortunately, software assurance hasn't kept up with the times. Although the people making progress in application security, the gains are much slower than the stunning advances in software development.
Provided By SecurityTube.net
Open and flexible cloud orchestration
Based on open source Apache CloudStack, Citrix CloudPlatform is the industry's most flexible and open cloud orchestration platform. Leverage industry standard Amazon Web Service APIs and the rich partner ecosystem to expand and integrate value added solutions and services.
Provided By Citrix Online
Enabling the journey to IT-as-a-Service
Watch video to see how Citrix is helping customers enable their journey towards IT-as-a-Service with Citrix CloudPortal Business Manager and Citrix CloudPlatform.
Provided By Citrix Online
Come visualize the future with Many Eyes
Learn how you can join IBM Many Eyes – a thriving, growing community to generate and share visualizations.
Provided By IBM
IBM business analytics: One solution that covers the entire analysis spectrum
In this online demo, learn how IBM Business Analytics software includes capabilities that meet a broad range of analysis needs - from analytical reporting to predictive analytics.
Provided By IBM
Sales Cloud Overview
Animated Video: Smarter Selling with Oracle Sales Cloud Oracle Sales Cloud is Smarter Selling that will help reps sell more, managers know more, and companies grow more.
Provided By Oracle
Companies Grow More with Oracle Sales Cloud
Animated Video: Oracle Sales Cloud is Smarter SFA that helps Companies Grow More. Maximize revenue and optimize sales performance. Know what to sell your customers. And get more help from your marketers and partners.
Provided By Oracle
Reps Sell More with Oracle Sales Cloud
Animated Video: Oracle Sales Cloud is smarter selling that will help reps sell more. Oracle Sales Cloud enables sales reps to sell more anytime, anywhere and on any device and empowers them to grow their own pipeline without waiting for marketing.
Provided By Oracle
Collaborating for the Internet of Things
When it comes to developing solutions for the Internet of Things (IoT), they need to be connected, managed and secure. Learn from Tom Moore of McAfee, Jim Douglas of Wind River, and Kumar Balasubramanian of Intel how they are collaborating to streamline IoT integration by delivering consistent, reliable, integrated, end-to-end...
Provided By WindRiver
Speed to Lead
Speed to Lead with mid-range solutions to accelerate your business transformation.
Provided By Technologent
Drive Your Transformation
Drive your transformation to cloud computing.
Provided By Technologent
How Do I: Forecast Table Analysis Tool?
In this tutorial one will learn how to use the Forecast Table Analysis Tool for Excel. The Forecast tool uses the Microsoft time series algorithm to predict future values based on trends in existing time series data.
Provided By Microsoft Corporation
Windows Intune: PC Management With Cloud Services and Windows 7
Microsoft recently announced the beta of Windows Intune, a new solution that simplifies how businesses manage and secure PCs using Windows cloud services and Windows 7. Windows Intune is a comprehensive offering that includes PC management, malware protection, and Windows upgrades - all without the need to set up enterprise...
Provided By Microsoft Corporation
Learn How Microsoft Dynamics CRM Online Plus BPOS Deliver Greater Value
Please join one for the Microsoft-led seminar Learn How Microsoft Dynamics CRM Online Plus BPOS Deliver Greater Value, where the speaker will review two solutions from Microsoft Online Service, the Microsoft Business Productivity Online Standard Suite (BPOS), and Microsoft Dynamics CRM Online.
Provided By Microsoft Corporation
Refreshing Windows XP to Windows 7 Using a USB Drive (Part 3 of 6): Creating a Task Sequence
Task Sequencer in MDT 2010 contains the steps to be performed during LTI. Task sequences in MDT 2010 use the same task sequence engine as System Center Configuration Manager. The speakers are going to create a Task Sequence to do the Operating System install.
Provided By Microsoft Corporation
Refreshing Windows XP to Windows 7 Using a USB Drive (Part 2 of 6): Adding Applications, OS and Packages
Applications can be deployed as a part of the operating system image or after the operating system is deployed to the target computer. To prepare for deployment people will need to create an application portfolio that includes a list of applications and the compatibility status of each application.
Provided By Microsoft Corporation
Refreshing Windows XP to Windows 7 Using a USB Drive (Part 1 of 6): Creating a USB Deployment Share
Typically, target computers have high-speed, persistent connections to the deployment infrastructure. However, some target computers may connect to an intranet remotely or not at all. To deal with this, the MDT 2010 provides one with two methods for deploying operating systems and applications: Deployment share: This method uses a network...
Provided By Microsoft Corporation
Windows 7 Deployment - I Want My MDT
Is any one unsure of how to get the perfect Windows 7 image built with all one's applications? Is any one tired of searching through dozens of images for the right one when people deploy a new computer, wishing one could reclaim all that disk space that they use? Join...
Provided By Microsoft Corporation
TechNet Radio: An Interview With Microsoft Setup and Deployment MVP, Maik Koster
In today's episode, speaker welcomes Microsoft Setup and Deployment MVP, Maik Koster. Listen in as they chat about Enterprise deployment solutions as well as a program Maik help developed called the MDT Web FrontEnd, which gives users a customizable and flexible solution to access and configure the MDT Database.
Provided By Microsoft
Office 365 Jump Start (04): Microsoft Office 365 Identity and Access Solutions
In this podcast, the author describes the different identity options organizations have with Office 365. In the process, Mike explains the Identity Architecture, describes how federated authentication works and walks through several deployment scenarios.
Provided By Microsoft
Microsoft Virtual Academy - Success With Private Cloud (Module 3) : Extending Your Private Cloud to the Outside World
In this podcast one will see the benefits of extending their private cloud to the outside world. The speakers will cover what a hybrid cloud is and how extending their private cloud into a hybrid cloud increases the capabilities and benefits to their organization and to the IT Professional.
Provided By Microsoft
Office 365 Jump Start (10): Exchange Online Archiving & Compliance
The speaker shows IT Professionals several options for archiving and achieving compliance with Exchange Online. He shows how Personal Archive allows users to consolidate email while enabling simplified compliance management. Next Jeff covers e-discovery of email data and various protection capabilities.
Provided By Microsoft
Byte Caching, Compression, and WAN Optimization
In this podcast, the speaker discusses byte caching, compression ratios, their role in network latency, web application delivery optimization, F5's WebAccelerator and associated modules, corporate CIFS optimization, and TCP Stack and file caching.
Provided By F5 Networks
Dynamic Caching and Web App Performance
The speaker, architect at F5 Networks, discusses dynamic caching vs. static caching, Web application delivery, and the technologies involved in caching, like F5's WebAccelerator - an application delivery solution that enhances web application performance for mobile workers.
Provided By F5 Networks
IT Challenges and Web App Delivery Options
The speaker, product manager for Web Acceleration at F5 talks about the new challenges that IT managers face as more enterprise and small business operate in 'WANspace', and what technology considerations become necessary for optimized Web app delivery.
Provided By F5 Networks
Web App Acceleration 101
The speaker, product manager for Web Acceleration at F5 talks about application acceleration, the inherent challenges in Web application delivery, caching, and offload modalities that play a key role in optimized server content delivery.
Provided By F5 Networks
TR10: Cloud Streaming
In the Silicon Valley conference room of OnLive, Steve Perlman touches the lifelike 3-D face of a computer-generated woman displayed on his iPad. Swiping the screen with his fingers, Perlman rotates her head; her eyes move to compensate, so that she continues to stare at one spot. None of this...
Provided By MIT
TechEd 2011 Birds-of-a-Feather (Session 02): Silverlight, Flash, and HTML5/CSS, and the Winners Is?
The demand for rich Internet applications has increased the use of Microsoft Silverlight, Flash and now HTML5/CSS. Watch this open discussion about these competing, or maybe complimentary, technologies to determine how one can develop the best user experience for their solution.
Provided By Microsoft
Silverlight Game Development for Windows Phone 7 (Part 5 of 6): Advanced Graphics
In this podcast, the speakers cover the improved graphics that the Tic Tac Toe game implements. They discuss the basic 2-D graphics engine of Microsoft Silverlight as well as how people can implement 3-D graphics to give the game that extra appeal.
Provided By Microsoft
Code Analysis for C/C++
Listen to this podcast to learn more about Code Analysis for C++. The C/C++ Code Analysis tool is a static analyzer that is provided with the installation of Microsoft Visual Studio Team System or Microsoft Visual Studio Team Suite, which provides information to developers about possible vulnerabilities in their C/C++...
Provided By Microsoft
Silverlight Game Development for Windows Phone 7 (Part 4 of 6): Scoring and Collision Testing
In Part 4 of this podcast the speakers cover scoring and collision testing. In this podcast, the speakers cover the game logic that is needed to implement the modified version of Tic Tac Toe. They discuss some of the advanced features that game developers implement to determine when a score...
Provided By Microsoft
Silverlight Game Development for Windows Phone 7 (Part 3 of 6): Handling Input and Logic
In Part 3 the speakers cover handling input and logic. In this podcast, they show people how to begin to implement a basic version of Tic Tac Toe. They discuss the various input and output mechanisms that are needed to implement the game, as well as develop the basic game...
Provided By Microsoft
Virtualization Jump Start (09): Virtual Desktop Infrastructure (VDI) Architecture | Part 1
This is Part 1 of a two-part section and features the speakers providing a solid understanding of why Virtual Desktop Infrastructure (VDI) is important and how it can be implemented. Next, they provide a "Scenario-based" understanding of how organizations should determine with VDI approach may be the best to implement...
Provided By Microsoft
Virtualization Jump Start (07): System Center Virtual Machine Manager 2012
The speakers provide an advanced introduction to VMM 2012 in this module. Viewers will understand the key features and design goals of VMM 2012 as well as experiencing the Library and the concept of the "Fabric." Additionally, see how to perform basic configuration and management tasks with services and service...
Provided By Microsoft
Expanding your business with mobile enable portals
Listen in to get the key points on how to effectively and efficiently deliver and utilize web applications on any of the over 7000 mobile platforms currently in use. Write once and render to many!
Provided By IBM
TechNet Radio: Deployment Fundamentals 101 With Mikael Nystrom and Johan Arwidmark
In this podcast, the speaker welcomes two Microsoft Setup and Deployment MVPs - Mikael Nystrom and Johan Arwidmark. Listen in as they chat about Windows Deployment Services, the Microsoft Deployment Toolkit as well as their book Deployment Fundamentals Volume 1.
Provided By Microsoft
Introduction to the Rock Paper Azure Challenge
Get ready to play Rock, Paper, Scissors with a few twists! The speakers will introduce one to the newest version of the schoolyard game - played in the Windows Azure cloud (for weekly prizes!). In this webcast, they'll introduce you to the format of the game including an overview of...
Provided By Microsoft
Windows Azure Boot Camp: Windows Azure Migration Strategies
During this podcast, the speakers explore the challenges that one might face when one take a completely customized on-premises application to the cloud. They cover building out strategies for migrating data and compute to using the unique features of scale and high availability in the cloud.
Provided By Microsoft
Windows Azure Boot Camp: A Dive into Deployment and Management
Learn about the options available in Microsoft Visual Studio for deployment and management while working with Windows Azure. The speakers cover Server Explorer features, publishing options, connecting to storage, and how Visual Studio tools for Windows Azure work. They also discuss how to use certificates to configure Visual Studio to...
Provided By Microsoft
Applying Microsoft SDL Release Practices Within Windows Azure
In this podcast, the speaker, Co-Founder, Casaba, speaks about the Release phase of the Microsoft SDL and how to apply the Microsoft SDL release phase practices to applications built on top of Windows Azure. The speaker explains that the Microsoft SDL can apply to any cloud-based deployment, but focuses on...
Provided By Microsoft
Overview of User State Migration Tool
In this podcast the speaker will review the benefits and limitations of the USMT 4.0. The speaker will look at what versions of the Windows are supported for migration as well as what different options for user state migration are available for small, medium and large businesses.
Provided By Microsoft
Deploying a Secure and Productive Windows 7
The combination of Windows 7 and Microsoft Forefront Unified Access Gateway can help one accomplish key business goals, including BYOPC (Bring Your Own PC) initiatives. See how one can roll out Windows 7 and DirectAccess to achieve both one business goals and one security goals.
Provided By Microsoft
Secure Management and Access for Windows 7 Featuring Direct Access
Microsoft Forefront Unified Access Gateway (UAG) and DirectAccess in Windows 7 can simplify management and access for a variety of external Windows client scenarios. Authentication, end-point security, application security, and infrastructure planning play crucial roles in management and access.
Provided By Microsoft
Solving Enterprise Application Compatibility Issues With Internet Explorer 8
By far, the single largest obstacle to deployment of Windows Internet Explorer 8 for many organizations is the 10 years of accumulated Web applications that may have a dependency on Windows Internet Explorer 6. How big is the problem really? How can people address it using best practices gleaned from...
Provided By Microsoft
Managing Internet Explorer 8 in the Enterprise Using Group Policy
One of the benefits of the Windows Internet Explorer 8 browser is manageability; there are a huge number of Group Policy objects, preferences, and tools available. But how do people take advantage of this manageability to deploy a browser configured in a way that works for you?
Provided By Microsoft
Technical Talks With Tim Vander Kooi: Windows 7, Under Your Control
The Speakers discuss and demonstrate many of the features and tools that one can use to tailor one Windows environment to meet one organization's needs. From Group Policy to management in the cloud (Windows Intune), learn how one can put Windows 7 under one control.
Provided By Microsoft
Talk TechNet With Keith Combs and Matt Hester - Episode 19: Justin Rodino on Deployment
Talk TechNet is all about discussing topics and trends in the world of IT Professionals. In this podcast the speakers will have guest Justin Rodino. Justin is a Microsoft Technology Solutions PM and former Microsoft Deployment MVP. Call in and join them for what promises to be a lively 60...
Provided By Microsoft
Offline User State Capture in the USMT 4.0
One of great new features of the USMT 4.0 is the ability to perform Offline User State Capture. The speakers will discuss both offline options available, Windows PE and windows.old directory. They will cover when one would use this feature and what it actually migrates.
Provided By Microsoft
Hard-Link Migration in the USMT 4.0
In this podcast the speaker will drill down in the Hard-link Migration option, one of the most compelling new features of USMT. They will look at why it greatly enhances the performance of a migration and finally they will see how to use the Scanstate and Loadstate tools.
Provided By Microsoft
User State Migration Tool Scenarios
Before taking a look at the two scenarios, Refresh Computer and Replace Computer, the speakers will review the different types of migration stores available. They will look at the migration xml files and show how they can do some simple customizations.
Provided By Microsoft
What's New in the User State Migration Tool 4.0
In this podcast the speaker will show some of the new features of User State Migration Tool (USMT) 4.0 including the Hard-link Migration Store, improved space estimation and integration with SCCM and MDT. The speaker will drill down into a detailed discussion of exactly what the USMT 4.0 migrates and...
Provided By Microsoft


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- Comedy
- Theatre & Shows
- Sport
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- Anywhere In The UK
- Location: Anywhere in the UK
Radius: ... miles
Shows are held in either St. John's Church or the attached Church Room which can seat up to 300 and 100 respectively in unreserved seating. A licensed bar serving beers, wines, hot and cold drinks is situated in the Church Room together with merchandise stalls.
All shows start at 7:45pm with doors open from 7:00pm and there is usually one interval. Parking on street or at nearby Farncombe mainline railway station which is 2 minutes walk away.
Previous headliners have included Kiki Dee, Jim Diamond, Charlie Dore, Julie Felix, Gordon Giltrap, Iona, Paul Jones, Martyn Joseph, Steve Knightley, Hazel O'Connor,Tom Russell, Eve Selis, Stackridge and After The Fire. Genres range from traditional folk right through to progressive rock.
Image © St. John's Church
16 upcoming events at St. John's Church:
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July 2015
Brian Player's Acoustic Cafe:
Ady Johnson, Hannah Clapham, Stick In The Wheel
St. John's Church (GU7 3EJ)
September 2015
October 2015
November 2015
The Music Of Ronnie Lane:
Slim Chance
St. John's Church (GU7 3EJ)
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Mari Wilson, Mari Wilson's Ready Steady Girls
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May 2016
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Venue Facts
Venue: St. John's Church
St. John's Street
Website: farncombe.org.uk
Enquiries: 01483 421520
→ Farncombe 4 min walk
News and Announcements RSS feed
- Wednesday 10th Jun: St. John's Church, Farncombe added a new listing
Have Your Say
Great acoustics, great atmosphere, just a great night out with such fabulous artists. Seen an amazing collection of gigs, especially Stackridge and Andy Fairweather Low.
Well done and many thanks Julien, keep up your fantastic work. Steve
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Want to see which region got what content? Look no further, as PlayStation LifeStyle has done the searching for you and compiled a list of what's new in this week's PlayStation Store Update, for all regions across the globe.
(Buzz!: Quiz TV , Fat Princess, Guitar Hero World Tour, Madden '10, Madden 2010, Madden NFL 10, Madden NFL 2010, Minna de Spelunker, PS3, PSP, Rag Doll Kung Fu: Fists of Plastic, Rock Band, Rock Band 2, Rock Band Unplugged, Tiger Woods PGA Tour 10, Watchmen: The End is Nigh Part 2)


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Holly Hanson@hollyhanson active 2 years, 3 months ago
Holly Hanson wrote a new post, The Dress That Opened Doors 2 years ago
Holly Hanson wrote a new post, Party With a Purpose 2 years, 8 months ago
Hi Tammy, the invitation was just a sample from my daughter's party 2 years ago. Feel free to use the information to host your own party, however, and have a great time!
Melodee, What a fantastic opportunity to go see your donation in action! I am so excited that you were able to meet the people you are serving. I admire your church's efforts to do SO much for others, it's truly […]
Dawn, you can check out http://www.causelife.org to get donor information and promotional materials. When I did my party two years ago, I pieced it all together myself. Now, it's practically all done for you, so it makes […]
I read the book "Causelife-Water Equals Life" by Noel Brewer Yeatts and Vernon Brewer. You can get a free copy of the book by visiting this link. http://www.worldhelp.net/causelife/
Robin, I love that you want to share this opportunity with your children! I have a personal relationship with the folks at http://www.Causelife.org, but you can choose any water charity that offers an opportunity for […]
Holly Hanson changed their profile picture 2 years, 9 months ago


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The Grant County Lady Braves softball team pulled off a big win on May 18, in the 32nd District battle against Walton-Verona.
The 2-1 victory avenged two earlier season losses against the Lady Bearcats for the Lady Braves.
Savannah Cobb took the mound and scattered seven hits over the seven innings that she pitched.
The Lady Braves played great defense behind her, committing only three errors in the game.
One of those errors was in the second inning where the Lady Bearcats could have had a big inning.
The Williamstown Lady Demons played host to the districts this year and entered their District 32 game with Simon Kenton with a lot of confidence.
That confidence was destroyed when they lost 4-0 on May 18 at Williamstown High School.
Williamstown loaded the bases in the first inning but was not able to cross the plate.
That would be the last opportunity for the Lady Demons to score until the sixth inning when they left two runners stranded on the bases.
Williamstown collected only three hits on the night.
Recently the Grant County Alumni football team took the field against County Pride, a team consisting of players from Harrison, Bourbon, Montgomery and Clark County, in the first gridiron alumni game. The Braves, coached by former Head Coach Mike Davis and former Assistant Coach Ken Little, led the Braves that ranged from players of the 1996 team to the 2013 team to a 30-14 victory.
The Grant County High School Lady Braves softball team honored two seniors, Taylor Souder and Kaitlyn Kinman, on May 14.
Souder and Kinman have been devoted players for the Braves since sixth grade.
Souder has played varsity softball, starting since the seventh grade and is the daughter of Greg Souder and Jackie Perkins. Her favorite memory playing softball was simply that she enjoyed every minute that she had with her teammates.
Dry Ridge Police are searching for a knife-wielding suspect in an armed robbery on May 18 at Dollar General.
The robbery occurred around 9 a.m., according to Dry Ridge Police Chief Rick Kells.
"The (suspect) pulled a knife on (the employee) and told her to give him all the money that was in the cash drawer," Kells said. "A customer had pulled up in the parking lot and saw the guy in there. They are the ones who called 911. Then the customer left."
A former captain at the Grant County Detention Center last week amended a previous lawsuit to now include the current jailer and judge.
The original lawsuit, filed in October 2014, named Terry Peeples, former jailer, and former Grant County Judge-Executive Darrell Link as defendants.
A record number of voters are registered in Kentucky as the May 19 primary election inches closer.
Voters will cast their ballots for the statewide offices of governor/lieutenant governor, attorney general, state treasurer, and commissioner of agriculture.
Nearly 3.2 million Kentuckians appear on the voter rolls, beating the 3,147,157 registered for the general election held in November 2014.
The difference is an increase of approximately 1 percent, or 28,748 voters, over five months.
A fifth suspect has been apprehended and charged in connection with an April 26 home invasion in Dry Ridge.
Kentucky State Police on May 6 arrested 21-year-old George E. Pickett for his alleged involvement in an home invasion robbery on Michigan Avenue that led to a bullet grazing a woman's head.
Pickett is charged with first-degree robbery, first-degree burglary and second-degree unlawful transaction with a minor.
Four people, including, Daniel M. Swope of Dry Ridge, were arrested last week in connection with the robbery.
Copyright © 2015
The Grant County News is your source for local news, sports, events, and information in Dry Ridge, KY and the surrounding area.


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volatile organic compounds Companies in New Brunswick
Keyword: volatile organic compounds ×
Industry: Shipbuilding & Water Transport ×
Location: Canada ×
Location: New Brunswick ×
Ashtead Technology Ltd
based in Letchworth, UNITED KINGDOM
Ashtead Technology was formed in 1985 when Ashtead Group plc acquired SubSpek Limited, which at the time provided underwater positioning, survey and inspection equipment rental from a base in Aberdeen. In 1994 the Singapore base was opened, focussing on the offshore oil and gas industry and the subsea telecommunications cable market in Asia Pacific. The first US ...
Tecam Group
based in Llinars del Vallès, SPAIN
Tecam Group offers advanced environmental technology to reduce Air Pollution Emissions and to incinerate Industrial Waste, both generated during production processes from the Industry. Tecam Group designs, manufactures and installs Thermal Oxidizers (TO), Regenerative Thermal Oxidizers (RTO), Regenerative Catalytic Oxidizers (RCO), Zeolite Rotor-Concentrator + ...
Ship & Shore Environmental, Inc.
based in Signal Hill, CALIFORNIA (USA)
We engineer, design and fabricate Air Pollution Abatement Systems for industrial clients that are required by air quality authorities to collect and destroy emissions generated by their manufacturing operations. These emissions are commonly known as Volatile Organic Compounds (VOC's), hydrocarbons, solvent fumes, halogenated hydrocarbons, and hazardous air pollutants ...
Crowcon Detection Instruments Ltd - a Halma company
based in Milton Park, UNITED KINGDOM
Crowcon Detection Instruments develop, manufacture and market a complete range of portable and fixed gas detection products you can trust to protect people and plant against gas hazards. Established over 40 years the company has strong regional centres in North America, Singapore, The Netherlands and India, with a mature network of trained distributors covering almost ...
based in Boynton Beach, FLORIDA (USA)
HGI Industries' has created cutting edge ultra violet hydroxyl generating technology which has been at the forefront of high volume odor processing,air-decontamination and air-purification for the past decade.HGI's patented technology is the world's ONLY scientifically proven non-contained Hydroxyl Generator. This non-chemical device provides an environmentally safe ...
Simple Solutions Dist. LLC
based in West Milford, NEW JERSEY (USA)
Simple Solutions Dist LLC is a registered small business founded in 2003 and located in the state of New Jersey. The manufacturer of the Wolverine Brand of activated Carbon filters, our products are utilized for air stream filtration with a focus on the waste-water odor caused by hydrogen sulfide (H2S) gas emissions. We manufacture a complete line of activated carbon ...
Grundfos Alldos
based in Reinach, SWITZERLAND
GRUNDFOS Water Treatment GmbH is an innovative supplier of high-quality products and services in the environmental technology and water treatment sectors. We develop, manufacture and market dosing pumps, disinfection systems, dosing systems as well as the associated measuring and control technology for these sectors. Using our knowledge of the markets and processes, we ...


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Providing copious amounts of chicken soup and orange-juice when your snugglebunny has the sniffles, taking them for tandem bike-rides or being the first to change your relationship status on social networking sites are some of the more subtle romantic gestures. Go big or go home with today's Groupon and spend a night with your significant other at Vintage Hotel for R500.
One of Durban's newest deluxe collections of rooms, Vintage Hotel finds its home in the trendy and upmarket suburb of Morningside. Within shouting distance of the city centre, it doesn't matter whether you're a tourist, touring wanna-be rockstar or just looking to get out of your own house for a night; Vintage Hotel is the newest place to be seen and the elegant British-era architecture is eye-pleasing accommodation for both history buffs and those who never even took the subject in school.
For those looking to get away from the hustle and bustle of daily life, seek solace in the sumptuously decorated rooms. Even if you spend all day on the bed, cosier than a cat in a basket full of fresh laundry, or just lazing about watching telly, the classically comfortable rooms offer the perfect place to do that. Maybe you could just get in a good cuddle session before you hit one of the nearby greens or blow some moolah on new shoes at the mall. Close to some major attractions like stadiums and race-courses, there's no shortage of shenanigans to fill your day with.
In the morning, when you finally win the battle with your alarm clock and manage to drag yourself out of bed, start the day in style with a delicious breakfast. Knowing it's not you that has to stand in the kitchen scrambling eggs always makes the food taste better. Use two Groupons on your visit to stay for two consecutive nights; perfect for an end-of-week getaway, a romantic getaway or just a getaway to watch The Getaway.
Hotel Fact: The CRAZY TOWN hotel in east-Texas was a getaway destination created especially for celebrities looking to take some time out from their busy lives. The hotel keeps half of its accommodation open for non-celebrities, though rooms need to be booked as far as ten years in advance. All guests at the hotel need to wear baseball caps, fake glasses and stick-on moustaches at all times.


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Jon Bon Jovi and The Kings of Suburbia
Sun, Mar 24, 2013 8:00 pm
The Joint – Hard Rock Hotel Las Vegas, Las Vegas, NV
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Re: Garden Club Meeting - October 2012[ Edited ]
10-01-2012 10:55 AM - edited 10-01-2012 11:00 AM
lithium78 wrote:
Tommy5746 wrote:
lithium78 wrote:
Well, I'm still in the garden, but I'm edging toward leaving the garden to get a credit union credit card due to my ongoing unemployment. It hasn't come to it yet and I've been holding off on any apps because I want to get a mortgage next year, but I've been unemployed for three months now so I have to take every possibility into consideration. If it becomes necessary, I'd rather have to carry a balance on a high CL, low interest credit union credit card rather than my high interest rewards cards.
I'm still clutching my platinum spade right now, though, and I really don't want to have to lose it. :-(
I wish you the best in finding a job!!
Thanks! All those politicians who say that unemployed people are just lazy have no idea what they are talking about. I've been trying to find a job that will pay the bills for 3 months and I've had 7 interviews and no offers. The competition is so fierce, especially in my field (education), which has faced drastic layoffs over the past four years. I really want to be careful not to screw up my credit.
That said it all. They don;t know what they are talking about. I have a friend who was in the Radar testing field at Raytheon still unemployed with a Masters Degree. IT's been 8 months for him. He took some additional training on several programs and still nothing. The competition out there is brutal. I think he went to like 12 interviews. I feel for you.
Good luck in your search.


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The text is generated dynamically so the value is not know ahead of time.
For example with:
<input id="a_input_id" type="text">
@r.SpecialField
When someone clicks that link the text field with be populated with the value of


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By Heather the heathen
from Scarborough,Ontario
Not disappointed at all. Nice ring made small though
Bottom Line Yes, I would recommend this to a friend
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By Penny
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Always wanted to get something with the druzy so thought I would start here. Seriously dissapointed and will be returning this ring. Nicer on screen than on my finger.
Bottom Line No, I would not recommend this to a friend


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Brady has sore throwing shoulder
Updated: August 29, 2009, 2:29 AM ETESPN.com news services
LANDOVER, Md. -- New England Patriots quarterback Tom Brady has a sore throwing shoulder, the result of a crushing hit by Washington Redskins defensive tackle Albert Haynesworth.
Brady's right shoulder was pressed to the ground by Haynesworth on an incomplete third-down pass late in the first half of Friday night's preseason game.
Brady went to the bench, where he flexed and rotated his arm as the half came to a close. He did not play in the second half, even though most of ...
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YIELD: Serves 2; can be doubled
Sprinkle chicken on all sides with cumin, salt and pepper. Heat oil in heavy medium skillet over medium heat. Add chicken and sauté until brown, about 2 minutes per side. Push chicken to side of skillet. Add garlic to skillet and stir 30 seconds. Add dried fruits, wine, broth and olives and bring to boil. Simmer chicken uncovered until just cooked through, turning chicken occasionally with tongs, about 10 minutes. Transfer chicken to plates. Increase heat and boil until sauce is slightly thickened, about 4 minutes. Spoon sauce over chicken.


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to FDA to examine the differences between the organism as it appears in that yogurt product and the organism as it appears in a supplement? Levy responded that the answer lies in intended use or effect. If the intended effect of the organism in the original product was the same, then yes, that is a valid approach.
There was a question about a hypothetical probiotic product designed to be administered to cesarean section (C-section) babies in an effort to establish a microbiota that is similar to that developed by a vaginally delivered baby. Would such a product be considered by FDA to be a food or a drug? Levy replied that it is unclear what that type of product would be considered. He would encourage discussion with "representatives from both sides of the agency."
Another participant asked under what circumstances a probiotic is considered a new dietary ingredient as opposed to a food additive. Levy described that type of categorization as "a gray area" because it often depends on how the food is intended to be marketed. He also pointed out that each category has its own safety evaluation paradigm. "However it is represented," he said, "you have to meet the requirements of that particular paradigm."
Finally, when asked whether any probiotics or prebiotics are being self-determined as generally recognized as safe (GRAS) food ingredients, Levy replied, "It would not surprise me if a lot of people are doing GRAS self-determinations." However, because GRAS self-determination does not require FDA notification, FDA does not have a complete list of such determinations although there are procedures that allow voluntary notification of FDA. GRAS determinations, however, are limited to ingredients in conventional foods, not dietary supplements. Mary Ellen Sanders added that she knew of about six GRAS notices for probiotics posted on the FDA website.
The U.S. regulatory landscape for foods is governed not just by FDA, but also by the Federal Trade Commission (FTC). Michelle Rusk explained how the two agencies share authority on marketing claims not just for foods, but also for supplements, drugs, and other health and medical products. Specifically, through a long-standing liaison agreement, FDA has primary authority for claims appearing on labeling or product packaging, while FTC has primary authority for claims appearing in advertising (with the exception of prescription drugs, over which FDA has authority on both labeling or packaging and advertising). By "advertising," Rusk was refer-
12 This section summarizes the presentation of Michelle Rusk.


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The present invention relates to a method of preparing a coated hollow polymeric tubular member useful in medical devices. The method involves a simple, unique method of simultaneously extruding and coating the polymeric tube.
1. A method of preparing a flexible polymeric catheter tube having an inner surface and an outer surface useful in medical devices using a single extruder and comprising forcing a stream of a molten base polymer into an entry port at one end of the extruder shaping die said shaping die also having a discharge port, and applying a hydrophilic lubricious coating to said tube at a coating thickness that is about 0.2% to about 20% of the total of the wall thickness of the tube and the thickness of the coating prior to said tube exiting said discharge port.
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20. A method of preparing a flexible polymeric catheter tube having an inner surface and an outer surface useful in medical devices using a single extruder comprising forcing a stream of molten base polymer into an entry port at one end of the extruder shaping die said shaping die also having a discharge port, and applying a lubricious coating by spraying said lubricious coating on said tube or by pumping said lubricious coating to a channel in said extruder shaping head and circulating said lubricious coating around said tube thereby applying said coating to said tube prior to said tube exiting said discharge port.
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The present invention relates to a unique coating process that involves the simultaneous extrusion and coating of polymeric tubes.
Medical devices for insertion into the body such as catheters and dilatation balloons attached to the distal end of such catheters, are formed from polymeric materials such as polyolefins including polypropylene and polyethylene, ethylene copolymers, polyvinyl chloride, polyurethane, polyesters, polyamides, polyether block amide elastomers, other thermoplastic elastomers, and so forth. These materials are typically inherently nonlubricious. It is desirable that these surfaces be lubricated for a variety of reasons including the reduction of catheter or wire movement frictions, the minimization of thrombosis, tissue trauma, tissue adhesion, pain, and so forth.
Coatings are commonly used in the medical device area for rendering such inherently non-lubricious substrate surfaces lubricious, as well as for protecting the surfaces of these devices, especially dilatation balloons. These coatings may be either hydrophilic or hydrophobic. Furthermore, because such medical devices are often inserted through the skin and into the body and are withdrawn at a later time, or as noted above, travel over long distances through small orifices, it is also necessary to have coatings which can be retained on the surface of the device for a long period, even when exposed to an aqueous environment, and is stable throughout the medical procedure.
Common hydrophobic coatings include fluoropolymers, siloxanes, mineral oil, sesame oil, glycerine, olive oil, polytetrafluoroethylene, and so forth. Hydrophobic coatings of an oily nature, have low surface energies and have a tendency to bead up and migrate over the surface of the device.
Another approach for reducing the coefficient of friction is to add a layer of a low friction material such as polytetrafluoroethylene, hereinafter PTFE and commonly known by the tradename of Teflon�. The problem with the use of PTFE is that it typically requires a separate extrusion process, and also requires etching. Adhesion is also generally a problem between the PTFE and the polymeric materials from which medical devices are made.
Hydrophilic coatings, upon exposure to an aqueous environment, can also migrate from the surface of the device which decreases the efficacy of the lubricious coating, particularly when the coating is in a liquid or gelled state.
There have been a variety of approaches utilized in order to increase the retention time of coatings on the surface of the medical device. These methods include altering the surface of the device such as through high energy radiation, bonding the coating to the surface of the device by direct chemical bonding, in situ polymerization processes, or by forming interpolymer networks.
The radiation process suffers from inconsistency and unreliability in alteration of the polymeric surface, and can produce radiation damage to the substrate. Interpolymer networks can be disrupted and break with turbulent flow, or with extended periods of exposure to an aqueous environment, resulting in the hydrophilic portion washing away from the surface of the device. Chemical bonding and in situ polymerization often decreases process efficiency due to the fact that typically several steps are involved in such a process.
In U.S. Pat. No. 4,373,009 to Winn, a substrate surface is primed with solution of a polyisocyanate, followed by a solution of a hydrophilic copolymer. The hydrophilic copolymer is capable of chemically reacting with a coupling agent which will promote adhesion to the substrate.
U.S. Pat. No. 4,720,521 to Spielvogel describes a film-forming silicone composition having a non-reactive lubricating component which is a siloxane polymer dispersed or distributed within a reactive component which is a mixture of siloxane polymers, such that when the composition is applied to or used in conjunction with a substrate surface, it coats and adheres to the surface while providing surface lubrication.
U.S. Pat. No. 5,084,315 issued Jan. 28, 1992 to Karimi et al. describes a coating composition which has at least two and preferably three or more components. The first component is a hydrophilic lubricating polymer which provides lubricity to the coated article when wet. The second component is a polymeric matrix material which serves as a carrier for the lubricating polymer and as a binder to provide adherence of the coating composition to the base polymer. The nature of the matrix polymer depends on the base polymer and preferably includes a polyurethane. For instance, when the base polymer is PVC, the matrix material preferably is an alloy of PVC and the matrix polyurethane.
U.S. Pat. No. 5,266,359 issued Nov. 30, 1993 to Spielvogel describes a coating composition for an article which comprises an aqueous emulsion of a surfactant and a noncuring polysiloxane lubricant substituted by a polar group, referred to by Spielvogel as the polar lubricant. Spielvogel states that the lubricant used on a metal article, because of the polar group, is adsorbed into the metal and adheres to the surface significantly reducing the wipe-away that occurs when inserting the medical device into the skin. Spielvogel discloses that a plastic catheter tubing may also be coated with the polar lubricant, but preferably is coated with a nonpolar polysiloxane lubricant, and specifically mentioned is trialkylsiloxy terminated polysiloxane.
U.S. Pat. No. 5,919,570 to Hostettler et al. issued Jul. 6, 1999 describes tenaciously adhering coatings of commingled hydrogels composed of a polyurethane/urea polymer hydrogel in combination with at least one dissimilar hydrogel, i.e. poly(N-vinylpyrrolidone) polymer hydrogel, and a process for making such commingled hydrogels, especially where the substrate materials to which they are applied are polymeric materials which are intrinsically non-polar and hydrophobic. Hostettler et al. further describes a process whereby the surface of the hydrophobic polymers are treated in order to render them more polar and hydrophilic so that the tenaciously adhering, slippery commingled hydrogel coatings may subsequently be applied to the polymer surface.
U.S. Pat. No. 5,824,173 issued Oct. 28, 1998 to Fontirroche et al. describes a method of making an intravascular balloon catheter which includes forming an inner shaft by coextruding a flexible plastic tube by bringing a molten outer plastic layer into contact with a molten inner plastic layer, thereby bonding the plastic layers together during the coextrusion process. The inner plastic layer may be more lubricious than the outer plastic layer.
U.S. Pat. No. 5,061,424 issued Oct. 29, 1991 to Karimi et al. describes a method for coextruding a melt of a substrate polymer and a melt of a coating composition comprising polyvinylpyrrolidone and a base polyurethane which gives a shaped article of a substrate polymer with a layer of a coating composition that becomes lubricious when the substrate comes into contact with a liquid.
Surprisingly, the influence of the chemical and physical composition of body fluids, as well as the dynamic forces of the bodily fluids, has a drastic influence on the permanence or retention of the coatings used on medical devices. Hydrophilic polymers may be washed from the surface by bodily fluids and silicone coatings tend to bead and lose their efficacy in the presence of bodily fluids.
Accordingly, there remains a need in the art of medical devices for coatings that are both lubricious and increase the durability of the balloon which have superior retention or wear permanence on the surface of medical devices, especially those constructed from polymeric materials.
The present invention relates to a method of applying a lubricious and protective coating to a polymeric tube simultaneously with extrusion of the tube while the tube is at temperatures of greater than ambient. The tube may be coated on the inside and/or outside as it is being extruded. It is an object of the present invention to provide a one step process that combines the extrusion and coating processes of tubular members that may be used in medical devices. A thin coating is preferably provided on the inside of the tubular member. The coating method, in addition to providing efficiency in the manufacturing process, also provides improved adhesion, and retention, of a lubricious coating to a polymeric medical device.
Specifically, the present invention relates to a method of preparing a coated hollow polymeric tube by extrusion. The tube has an inner surface and an outer surface. The method involves forcing a stream of molten base polymer into an entry port at one end of an extruder shaping die, and applying a coating to the base polymer while it is in the shaping die of the extruder, and prior to the tube exiting the discharge port of the shaping die. The coating is therefore applied while the tube is in its molten form. The coating may be applied either to the inner surface of the tube, or to the outer surface of the tube.
This coating method simplifies the process while improving adhesion without surface priming or chemical bonding. Applying the coating to the polymeric tube during extrusion while the tube is above ambient temperature provides better adhesion of the coating to the tube.
These coated tubes may be used in medical devices such as catheter assemblies.
FIG. 1 shows generally at 10, an extrusion crosshead or extrusion shaping head designed for forming tubular members which can be used in medical devices. The tubular member is formed of a thermoplastic polymeric material. The extrusion unit has a nozzle through which the coating may be applied the inside of the polymeric tubular member.
FIG. 2 shows generally at 11, an extrusion crosshead or extrusion shaping head designed for forming hollow tubular members which can be used in medical devices. The extrusion unit has a channel 42 for coextrusion of a coating on the inner surface of the polymeric tube.
FIG. 3 shows generally as 12, an extrusion crosshead or extrusion shaping head unit designed for forming hollow tubular members which can be used in medical devices. The extrusion unit has a flow channel 38 through which the coating is pumped for coextrusion of the coating on the outer surface of the polymeric tubular member.
The following description of the preferred embodiments of the present invention is merely illustrative in nature. One of skill in the art would understand that numerous modifications may be made to the present invention without departing from the true spirit and scope of the present invention.
Generally, a stream of a viscous melt of the base polymer is forced under pressure in a continuous stream through an entry port (20) from extruder mounted at one end of the shaping die 10. The viscous melt typically exits the extruder die at a discharge port 46 into a cool water bath.
FIG. 1 illustrates generally at 10, an extrusion shaping head or crosshead for forming polymeric tubular members useful in medical devices. Extrusion Head has an entry port 20 from extruder located at a first end of the extruder shaping mandrel 18 which supplies a stream of molten thermoplastic material to flow channel 28. The molten thermoplastic material flows in channel 28 around an air flow channel 44 through which an air source 22 flows for keeping the diameter of the tubing consistent through the use of pressure. The molten polymeric material flows around the extruder shaping mandrel 18 through a discharge port 46 located at one end of the extruder shaping mandrel 18 forming hollow tubing 26 which flows into a cool water bath. A nozzle 34 with a supply means 32 for supplying coating material to the nozzle 34 applies coating to the inner surface of the extruded polymeric tubing 26. The nozzle 34 generally applies the coating by spraying means. The coating is applied to the extruded tubing 26 at the nozzle head 34 prior to exiting of the tubing 26 from the discharge port 46 located at a second end of the extruder shaping mandrel 18 prior to cooling of the tubing 26, and while tubing 26 is at temperatures of approximately 150-300� C.
FIG. 2 shows generally at 11 an extrusion shaping head or crosshead unit for forming polymeric tubing. The extruder configuration is similar to that found in FIG. 1. The extruder unit has an entry port 20 located at a first end of the shaping mandrel 18 for supplying a stream of molten polymeric material to a channel 28. Additionally, crosshead has a second entry port 42 for supplying a coating to channel 48. The coating composition may be pumped through a second entry port 42 and into the channel 48 using a volumetric gear pump. This allows application of the coating to the inner surface of the hollow tubular member as it is being extruded at high temperatures of about 200� C., thereby improving the adhesion between the tubing and the coating. In other respects, the extruder units in FIG. 1 and FIG. 2 are substantially the same.
FIG. 3 shows generally at 12 an extrusion shaping head or crosshead unit for forming hollow polymeric tubing. This unit is similar in construction to those found in FIGS. 1 and 2 and has an entry port 20 for supplying a stream of molten polymeric material to a channel 28. Additionally, extrusion head 12 has a means 38 of supplying lubricious coating into a second entry port 21 which forces said coating into a half circle channel 40 in which coating material is circulated around, and thereby contacting the molten polymeric material. The means 38 of supplying the coating may be a volumetric gear pump, or other pumping means. The molten polymeric material is extruded through the extruder shaping mandrel 18 and is circulated around air flow channel 44 through which an air source 22 flows to maintain constant pressure and to facilitate a consistent tubing diameter. The tubing then exits the extruder shaping die through the discharge port 46 into a cool water bath with the coating on its outer surface.
One of skill in the art would recognize that various modifications may be made to the extrusion process without departing from the scope of the present invention.
The tubing 26 is formed from what is referred to herein as the polymeric base material, and may be comprised of any extrudable polymeric material from which medical devices are typically produced including various organic high polymers such as polyesters, polyamides, polyurethanes, polyurethaneureas, polyolefins such as polypropylene and polyethylene, polyolefin copolymers and terpolymers, polycarbonates, polyvinyl acetate, thermoplastic elastomers including polyether-polyester block copolymers such as the Hytrel� series of block copolymers, also referred to as thermoplastic polyester elastomers, available from DuPont in Wilmington, Del. or the Arnitel� series available from DSM, the Netherlands, such as Arnitel� 540 and polyamide/polyether/polyesters elastomers such as PEBAX� 6333, 7033 and 7233, polyvinyl chloride, polystyrene, polyacrylate, polymethacrylate, polyacrylonitrile, polyacrylamide, silicone resins, and so forth, and copolymers and blends thereof. This list is intended as an illustration of the types of materials which may be utilized in the present invention and is not intended as an exclusive list.
The tubular member may form any type of catheter including balloon catheters and stent delivery catheters, retractable sheaths or stent retaining sleeves for stent delivery catheters, guide wire lumens, pull wire lumens, and so forth.
Balloon catheters have an inflatable balloon, otherwise referred to as a dilatation balloon, mounted at the distal end. The tubular member of the present invention may be an extruded preform which is subsequently blown into a dilatation balloon. This is a typical method of balloon formation. The coating is applied to the preform prior to the preform exiting through the discharge port of the shaping die. The coating may provide lubricity to the balloon, as well as improve the durability of the balloon.
Suitable balloon forming techniques which may be employed are well known in the art and may be carried out in any conventional manner with conventional extrusion and blowing techniques. Such techniques for balloon formation are discussed in U.S. Pat. No. 4,490,421 to Levy and in U.S. Pat. No. 5,348,538 issued Sep. 20, 1994 to Wang et al. herein incorporated by reference.
Catheters assemblies are useful in a variety of medical procedures such as coronary angioplasty, stent delivery and placement for the opening of occluded or blocked blood vessels, for urological and reproductive surgeries, and to deliver biologically compatible fluids, such as radiologically opaque fluid for contrast x-rays to precise locations within the body.
The coating may comprise a liquid material. Preferably, the liquid material has good thermal stability, i.e. high degradation temperature, a high boiling point of greater than about 400� F. (204.4� C.), and a viscosity of about 300 cPs to about 1000 cPs at the temperature of application.
The coating preferably comprises a hydrophilic compound including alkylene glycols, alkoxy polyalkylene glycols such as methoxypolyethylene oxide, polyoxyalkylene glycols such as polyethylene oxide, polyethylene oxide/polypropylene oxide copolymers, polyalkylene oxide-modified polydimethylsiloxanes, polyphosphazenes, poly(2-ethyl-2-oxazoline), homopolymers and copolymers of (meth) acrylic acid, poly(acrylic acid), copolymers of maleic anhydride including copolymers of methylvinyl ether and maleic acid, pyrrolidones including poly(vinylpyrrolidone) homopolymers and copolymers of vinyl pyrrolidone, poly(vinylsulfonic acid), acryl amides including poly(N-alkylacrylarnide), poly(vinyl alcohol), poly(ethyleneimine), polyamides, poly(carboxylic acids), methyl cellulose, carboxymethylcellulose, hydroxypropyl cellulose, polyvinylsulfonic acid, water soluble nylons, heparin, dextran, modified dextran, hydroxylated chitin, chondroitin sulphate, lecithin, hyaluranon, and so forth. The polymers are typically chain-structured, non-crosslinked and water soluble having a hydrophilic group such as —OH, —CONH2, —COOH, —NH2, —COO—, —SO3, —NR3 + and so forth where R is alkyl or hydrogen.
Derivatives of any of these polymers may be utilized providing that enough of the basic structure of the polymers above that provides water sensitivity, solubility or dispersibility is retained allowing the polymer to uptake enough water to swell or partially dissolve enough upon exposure to moisture to provide lubricity in such a way to reduce frictional forces between the surface it is coated on and another surface such as tissue, metal or polymeric surfaces. Water insoluble derivatives may be employed as long as they have the freedom in the molecular chain and can be hydrated. Examples include esterified polymers, salts, amides, anhydrides, halides, ethers, hydrolyzates, acetals, formals, alkylols, quaternary polymers, diazos, hydrazides, sulfonates, nitrates, and ion complexes which are obtained by condensation, addition, substitution, oxidation, or reduction reactions of the above-mentioned water soluble polymers. Also useful are polymers crosslinked with substances having more than one reactive functional group such as diazonium, azide, isocyanate, acid chloride, acid anhydride, imino carbonate, amino, carboxyl, epoxy, hydroxyl, and aldehyde groups.
Further polymers include those copolymerized with vinyl, acrylic acid, methacrylic acid, diene compounds, and so forth.
Copolymers with vinyl groups, diene compounds and maleic anhydride may also be utilized.
The polyalkylene glycols or alkoxy polyalkylene glycols have the following general formula:
R1 and R2 may be the same or different and can be H or an alkyl group having 1 to about 6 carbon atoms, x is from 2 to about 500; and y is from 0 to about 100.
The polyalkylene glycols and alkoxy polyalkylene glycols may also contain functional groups such as, for example, hydroxyl, sulfur, nitrogen or oxygen.
Hydrogel coatings may also be utilized which absorb water and swell upon exposure to an aqueous environment. Such polymers include polyethylene oxide and its copolymers, polyvinylpyrrolidone and its derivatives; hydroxyethylacrylates or hydroxyethyl(meth)acrylates; polyacrylic acids; polyacrylamides; polyethylene maleic anhydride and its derivatives; and so forth.
Carboxylic acid-containing polymers may form hydrogels such as copolymers of acrylic acid, methacrylic acid maleic acid, fumaric acid or other polymerizable ethylenically unsaturated acids. These compounds may optionally be neutralized.
Specific examples of hydrogel polymers include poly(ethylene-maleic anhydride) copolymers sold by Aldrich Chemical Co. and maleic anhydride-methyl vinyl ether copolymers sold by G.A.F. Corp. such as Gantrez� AN 169.
Maleic anhydride copolymers may also be chemically modified by partial reaction with a solution containing an anhydride or carboxylic acid reactive compound such as an amine, alcohol, epoxy or imine compound. The reactive compound may suitably be a low molecular weight monofunctional compound, in which case hydrophilicity will usually be reduced.
Another hydrogel polymer is one in which polyethylene oxide is captured in an interpenetrating crosslinked acrylic polymer network by polymerizing a mixture of an acrylic monomer composition comprising a monomer having plural (meth)acrylate groups and polyethylene oxide, thereby providing a hydrogel coating.
Monomeric materials may be useful for coating the polymeric tubes of the present invention. These monomeric materials can then be polymerized to create the coating layer. For instance, polymerization may be initiated through the use of actinic radiation including ultraviolet (UV) and election beam (EB) radiation. Other means of curing include chemical initiators, catalysts, heat, or any combination thereof. For instance, chemical initiators are commonly used in combination with UV radiation. Give some examples.
Polyfunctional compounds which produce surface crosslinking may also be employed. Polyethylene glycols or monohydroxy derivatives thereof may also be employed. Treatment of the coating with such reactive compounds may be combined with neutralization reactions of unreacted acid groups also obtained from the specific reactions or from hydrolysis of any unreacted anhydride groups remaining after such reactions.
The compounds of the present invention may be utilized in any combination to more narrowly tailor the resultant composition to the application. For instance, some of the hydrophilic polymers of the present invention exhibit less flexibility than others such as the hydrogels found in the previous paragraph. The flexibility may be improved by the addition of polyethylene oxide/polypropylene oxide copolymers, especially block copolymers, polyvinyl pyrrolidone, polyvinyl alcohol, and so forth.
In general hydrophilic coating materials are preferred as coating materials for use in the invention. They are more biocompatible and less irritating to human tissue than are hydrophobic coatings. The hydrophilic compounds can provide both lubricity and increased wearability to a balloon structure.
Examples of some of the preferable hydrophilic coating materials include the homopolymers and copolymers of vinyl pyrrolidone; polyacrylamides; polyethylene oxides; polyvinyl alcohols; (meth) acrylic acid homopolymers and copolymers; ionomeric polymers; polycarboxylic acids (optionally mixed with polyurethane); and so forth.
Polymers may be applied to the tubular member in a molten state. For ease of application, these materials will preferably have a viscosity of about 100 to about 1000 at the temperature of application. The coating thickness may be adjusted by changing the viscosity of the molten polymer and the feeding rate of the gear pump that supplies the molten polymer.
The coating thickness is about 1 to about 20 μm, preferably from about 1 to about 10 μm, more preferably from about 2 to about 6 μm and most preferably from about 2 to about 4 μm.
Utilizing the method of the present invention, the coating and the polymeric tube come into contact at elevated temperatures, i.e. at a temperature greater than ambient so as to improve the retention of the coating on the tube. The polymeric tubing may be at temperatures as high as 200� C. when the coating is applied as the coating is applied prior to the tubing exiting the extruder. Preferably, the temperature at the interface of the polymeric tubing and the coating will be greater than about 100� C., more preferably greater than about 120� C., and even more preferably greater than about 150� C. The higher the temperature, the more flowable the polymers will be, and subsequently, the mixing between the two should also be better, resulting in better adhesion. However, the temperature cannot be so high as to avoid melting or degrading the polymeric tube.
The coating may be applied at ambient temperatures, but the coating may be applied at elevated temperatures of about 100� C. to about 300� C. as well. For instance, the polymers may be applied out of the melt, i.e. when they are in a molten state. For most polymers, temperatures of application may vary between about 120� C. and about 205� C., and preferably between about 135� C. and about 190� C.
The higher the molecular weight of the polymer, the higher the application temperature required to render the material flowable enough to apply. The type of application will also play a role in determining how the coating may be applied. Some types of application methods require lower viscosities than others.
It is desirable to the present invention to achieve interpenetration at the interface between the low friction or coating, and the polymeric tube. It is surmised that the better the interpenetration between the two polymeric materials at the interface, the better the coating will be retained on the surface, and the more permanent the coating on the medical device. It is further surmised that better interpenetration can be achieved if the temperature at which the polymeric materials come into contact is elevated.
Essentially, the polymers, both the coating and polymer from which the tube is formed, must be at a temperature high enough so that they may flow and intermingle, thus resulting in interpenetration of the polymers occurring at the interface. It is surmised that molecules that are not located at the interface, are not interpenetrating.
The coating method of the present invention may be utilized to apply coatings on tubular members used in medical devices. The coatings may add lubricity to the device, as well as improving the durability of the device including improving the resistance to scratches, abrasions and punctures. This is particularly important for dilatation balloons.
The coatings of the present invention can be utilized to lower the coefficient of friction between the various parts of a catheter assembly which come into a moving or sliding relationship with one another. A common problem which occurs in catheter assemblies is friction or adhesion between various parts which occasionally come into contact with one another during the medical procedure. For instance, friction can occur between the guide catheter and guide wire, between the introducer sheath and the guide catheter, or between the guide catheter and the balloon catheter, for instance, and may increase the difficulty of insertion, cause loss of catheter placement, and result in discomfort to the patient or damage to the vasculature. It is therefore desirable to reduce the friction due to the sliding between the various parts of the catheter assemblies. For instance, guide catheters are introduced over a guide wire through a previously placed introducer sheath and advanced through a blood vessel to a precise location, such as a location of a stenosis. It is important that friction between the various parts of the catheter device is minimized.
The coatings of the present invention may therefore be utilized to improve the deployment of any of stents, stent-grafts, grafts or vena cava filters, or other such expandable medical devices, by coating the inner surface of the polymeric sheath to reduce the friction between the sheath and the stent.
The coatings of the present invention can also be used to improve the durability of, as well as add lubricity to, dilatation balloons, especially those formed of non-compliant balloon materials. The balloon wall may be noncompliant or compliant. Noncompliant balloons are formed from relatively stiff materials including polyethyleneterephthalate (PET), high density polyethylene, polyarnides, polycarbonates and stiff polyurethanes, and so forth. The balloon wall may also be compliant and made of materials such as polyvinyl chloride, polyethylene, polyester copolymers, polyolefin copolymers and so forth. The present invention provides a particular advantage when the balloon wall is made of a stiff, noncompliant material. Such materials tend to scratch more easily, especially if a fold occurs in the balloon. Scratches, abrasions and punctures on these balloons can ultimately result in damage to blood vessels.
There are vast number of various types of catheter devices commercially available and the present inventors envision that the coating method described herein may be employed in any such device.
The devices discussed herein are meant only for illustration as to how the coatings of the present invention may be utilized, and are in no way intended to limit the present invention. One of skill in the art would understand how to incorporate the coatings and method of the present invention to any other such devices.
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