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The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.
Publications from 2015
A laminin 511 matrix is regulated by TAZ and functions as the ligand for the alpha6Bbeta1 integrin to sustain breast cancer stem cells, Cheng Chang, Hira Lal Goel, Huijie Gao, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Sulev Ingerpuu, Manuel Patarroyo, Shiliang Cao, Elgene Lim, Junhao Mao, Karen Kulju. McKee, Peter D. Yurchenco, and Arthur M. Mercurio
RNA Interference in Caenorhabditis elegans, Darryl Conte Jr., Lesley T. MacNeil, Albertha J. M. Walhout, and Craig C. Mello
Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF, Sarah J. Hainer, Weifeng Gu, Benjamin R. Carone, Benjamin D. Landry, Oliver J. Rando, Craig C. Mello, and Thomas G. Fazzio
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans, Omid F. Harandi and Victor R. Ambros
Research resource: Monitoring endoplasmic reticulum membrane integrity in beta-cells at the single-cell level, Kohsuke Kanekura, Jianhong Ou, Takashi Hara, Lihua (Julie) Zhu, and Fumihiko Urano
Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, and Arthur M. Mercurio
Precision cancer mouse models through genome editing with CRISPR-Cas9, Haiwei Mou, Zachary Kennedy, Daniel G. Anderson, Hao Yin, and Wen Xue
Effect of transmission intensity and age on subclass antibody responses to Plasmodium falciparum pre-erythrocytic and blood-stage antigens, Gregory S. Noland, Paul Jansen, John M. Vulule, Gregory S. Park, Bartholomew N. Ondigo, James W. Kazura, Ann M. Moormann, and Chandy C. John
An efficient and sensitive method for preparing cDNA libraries from scarce biological samples, Catherine H. Sterling, Isana Veksler-Lublinsky, and Victor R. Ambros
Publications from 2014
NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone, Junya Awata, Saeko Takada, Clive Standley, Karl-Ferdinand Lechtreck, Karl D. Bellve, Gregory J. Pazour, Kevin E. Fogarty, and George B. Witman
Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan, Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr., Haibo Liu, Michael J. Gilchrist, Lesley T. MacNeil, and Heidi A. Tissenbaum
Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA, Hanni Bartels and Jeremy Luban
Genetic and pharmacological reactivation of the mammalian inactive X chromosome, Sanchita Bhatnagar, Xiaochun Zhu, Jianhong Ou, Ling Lin, Lynn Chamberlain, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green
PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion, Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Hyun Kyung Oh, Darren Reese Williams, D. Joshua Liao, Jianhua Zhou, Michael R. Green, Xuexiu Zheng, and Haihong Shen
Adipose tissue angiogenesis: impact on obesity and type-2 diabetes, Silvia Corvera and Olga Gaelekman
Distinct functions for IFT140 and IFT20 in opsin transport, Jacquelin A. Crouse, Vanda S. Lopes, Jovenal T. San Agustin, Brian T. Keady, David S. Williams, and Gregory J. Pazour
Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA, Alberto De Iaco and Jeremy Luban
Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice, Shuping Dou, John Virostko, Mary Rusckowski, Dale L. Greiner, Alvin C. Powers, and Guozheng Liu
Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach, Shuping Dou, Yuzhen Wang, Bruce A. Barton, Ling Chen, Mary Rusckowski, Leonard D. Shultz, Dale L. Greiner, and Guozheng Liu
The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype, Minggang Fang, Jianhong Ou, Lloyd Hutchinson, and Michael R. Green
Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour
Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters, Juan I. Fuxman Bass, Alex M. Tamburino, Akihiro Mori, Nathan Beittel, Matthew T. Weirauch, John S. Reece-Hoyes, and Albertha J. M. Walhout
A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection, Don B. Gammon, Sophie Duraffour, Daniel K. Rozelle, Heidi Hehnly, Rita Sharma, Michael E. Sparks, Cara C. West, Ying Chen, James J. Moresco, Graciela Andrei, John H. Connor, Darryl Conte Jr., Dawn E. Gundersen-Rindal, William L. Marshall, John R. Yates, Neal S. Silverman, and Craig C. Mello
Regulated splicing of the alpha6 integrin cytoplasmic domain determines the fate of breast cancer stem cells, Hira Lal Goel, Tatiana Gritsko, Bryan Pursell, Cheng Chang, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Leslie M. Shaw, and Arthur M. Mercurio
Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A, Romi Gupta, Yuying Dong, Peter D. Solomon, Hiromi I. Wettersten, Christopher J. Cheng, JIn-Na Min, Jeremy Henson, Shaillay Kumar Dogra, Sung H. Hwang, Bruce D. Hammock, Lihua Julie Zhu, Roger R. Reddel, W. Mark Saltzman, Robert H. Weiss, Sandy Chang, Michael R. Green, and Narendra Wajapeyee
Rab11 endosomes contribute to mitotic spindle organization and orientation, Heidi Hehnly and Stephen J. Doxsey
The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins, Andree Hubber, Kohei Arasaki, Fubito Nakatsu, Camille Hardiman, David G. Lambright, Pietro De Camilli, Hiroki Nagai, and Craig R. Roy
Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease, Chien-Min Hung, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Huawei Li, Clary B. Clish, Simone Hettmer, Amy J. Wagers, and David A. Guertin
Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8, Ha Na Jang, Minho Lee, Tiing Jen Loh, Seung-Woo Choi, Hyun Kyung Oh, Heegyum Moon, Sunghee Cho, Seong-Eui Hong, Do Han Kim, Zhi Sheng, Michael R. Green, Daeho Park, Xuexiu Zheng, and Haihong Shen
A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling beta-glucan microparticles, Magdia De Jesus, Gary R. Ostroff, Stuart M. Levitz, Toni R. Bartling, and Nicholas J. Mantis
Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells, Nicola A. Kearns, Ryan M. J. Genga, Metewo Selase Enuameh, Manuel Garber, Scot A. Wolfe, and Rene Maehr
Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes, Nora M. Kochupurakkal, Annie J. Kruger, Sudipta Tripathi, Bing Zhu, La Tonya Adams, Daniel B. Rainbow, Aldo A. Rossini, Dale L. Greiner, Mohamed H. Sayegh, Linda S. Wicker, and Indira Guleria
Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression, Benjamin D. Landry, Claudine E. Mapa, Heather E. Arsenault, Kristin E. Poti, and Jennifer A. Benanti
A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors that Repress FGFR Signaling, Ling Lin, Lynn Chamberlain, Magnolia L. Pak, Arvindhan Nagarajan, Romi Gupta, Lihua Julie Zhu, Casey M. Wright, Kwun M. Fong, Narendra Wajapeyee, and Michael R. Green
Cancer-Relevant Splicing Factor CAPERalpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex, Sarah Loerch, Alexandre Maucuer, Valerie Manceau, Michael R. Green, and Clara L. Kielkopf
A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia, Leyuan Ma, Yi Shan, Robert Bai, Liting Xue, Christopher A. Eide, Jianhong Ou, Lihua Julie Zhu, Lloyd Hutchinson, Jan Cerny, Hanna Jean Khoury, Zhi Sheng, Brian J. Druker, Shaoguang Li, and Michael R. Green
The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans, Katherine McJunkin and Victor R. Ambros
SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene, Heegyum Moon, Sunghee Cho, Tiing Jen Loh, Hyun Kyung Oh, Ha Na Jang, Jianhua Zhou, Young-Soo Kwon, D. Joshua Liao, Youngsoo Jun, Soohyun Eom, Claudia Ghigna, Giuseppe Biamonti, Michael R. Green, Xuexiu Zheng, and Haihong Shen
The hunt for protective correlates of immunity to Plasmodium falciparum malaria, Ann M. Moormann and V. Ann Stewart
IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis, Kimberly A. Negrin, Rachel J. Roth Flach, Marina T. DiStefano, Anouch Matevossian, Randall H. Friedline, Dae Young Jung, Jason K. Kim, and Michael P. Czech
miR-14 Regulates Autophagy during Developmental Cell Death by Targeting ip3-kinase 2, Charles Nelson, Victor R. Ambros, and Eric H. Baehrecke
MicroRNA-378 controls classical brown fat expansion to counteract obesity, Dongning Pan, Chunxiao Mao, Brian Quattrochi, Randall H. Friedline, Lihua Julie Zhu, Dae Young Jung, Jason K. Kim, Brian C. Lewis, and Yong-Xu Wang
Diversity and expression of microRNAs in the filarial parasite, Brugia malayi, Catherine B. Poole, Weifeng Gu, Sanjay Kumar, Jingmin Jin, Paul J. Davis, David Bauche, and Larry A. McReynolds
Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase beta and regulates complex V activity, Motiur Rahman, Niraj K. Nirala, Alka Singh, Lihua Julie Zhu, Kaori Taguchi, Takeshi Bamba, Eiichiro Fukusaki, Leslie M. Shaw, David G. Lambright, Jairaj K. Acharya, and Usha R. Acharya
Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration, Christian Reinhard, Dario Bottinelli, Baek Kim, and Jeremy Luban
Epstein-barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids, Nicholas Renzette, Mohan Somasundaran, Frank E. Brewster, James Coderre, Eric R. Weiss, Margaret M. McManus, Thomas C. Greenough, Barbara Tabak, Manuel Garber, Timothy F. Kowalik, and Katherine Ruiz De Luzuriaga
Adipocyte lineages: tracing back the origins of fat, Joan Sanchez-Gurmaches and David A. Guertin
A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype, Ryan W. Serra, Minggang Fang, Sung Mi Park, Lloyd Hutchinson, and Michael R. Green
RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast, JongDae Shin, Mary C. Wallingford, Judith Gallant, Chelsea Marcho, Baowei Jiao, Meg Byron, Michael Bossenz, Jeanne B. Lawrence, Stephen N. Jones, Jesse Mager, and Ingolf Bach
A separable domain of the p150 subunit of human Chromatin Assembly Factor-1 promotes protein and chromosome associations with nucleoli, Corey L. Smith, Timothy D. Matheson, Daniel J. Trombly, Xiaoming Sun, Eric Campeau, Xuemei Han, John R. Yates III, and Paul D. Kaufman
Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking, Sylvia Stockler, Silvia Corvera, David G. Lambright, Kevin E. Fogarty, Ekaterina Nosova, Deborah Marie Leonard, Robert Steinfeld, Cameron Ackerley, Casper Shyr, Nicolas Au, Kathrin Selby, Margot van Allen, Hilary Vallance, Ron Wevers, David Watkins, David Rosenblatt, Colin J. Ross, Elizabeth Conibear, Wyeth Wasserman, and Clara van Karnebeek
The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex, Yoshiko Usami, Sergei Popov, and Heinrich G. Gottlinger
Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain, Timothy R. Wagenaar, Leyuan Ma, Benjamin P. Roscoe, Sung Mi Park, Daniel N. Bolon, and Michael R. Green
Genetic adaptation to diet preserves longevity, Albertha J. M. Walhout
Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis, Jeanine Ward, Chitra Kanchagar, Isana Veksler-Lublinsky, Rosalind C. Lee, Mitchell R. McGill, Hartmut Jaeschke, Steven C. Curry, and Victor R. Ambros
Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals, Stefan Washietl, Manolis Kellis, and Manuel Garber
Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits, Emma Watson, Lesley T. MacNeil, Ashlyn D. Ritter, L. Safak Yilmaz, Adam P. Rosebrock, Amy A. Caudy, and Albertha J. M. Walhout
Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy, Emma Watson and Albertha J. M. Walhout
Determination and inference of eukaryotic transcription factor sequence specificity, Matthew T. Weirauch, Ally Yang, Mihai Albu, Atina G. Cote, Alejandro Montenegro-Montero, Philipp Drewe, Hamed S. Najafabadi, Samuel A. Lambert, Ishminder Mann, Kate Cook, Hong Zheng, Alejandra Goity, Harm van Bakel, Jean-Claude Lozano, Mary Galli, Mathew G. Lewsey, Eryong Huang, Tuhin Mukherjee, Xiaoting Chen, John S. Reece-Hoyes, Sridhar Govindarajan, Gad Shaulsky, Albertha J. M. Walhout, Francois-Yves Bouget, Gunnar Ratsch, Luis F. Larrondo, Joseph R. Ecker, and Timothy R. Hughes
Worms, bacteria, and micronutrients: an elegant model of our diet, L. Safak Yilmaz and Albertha J. M. Walhout
CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems, Lihua Julie Zhu, Benjamin R. Holmes, Neil Aronin, and Michael H. Brodsky
Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression, Anna Y. Zinovyeva, Samir Bouasker, Martin J. Simard, Christopher M. Hammell, and Victor R. Ambros
Publications from 2013
Nucleosome dynamics regulates DNA processing, Nicholas L. Adkins, Hengyao Niu, Patrick Sung, and Craig L. Peterson
Victor Ambros: the broad scope of microRNAs. Interview by Caitlin Sedwick, Victor R. Ambros
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice, Myriam Aouadi, Michaela Tencerova, Pranitha Vangala, Joseph Yawe, Sarah M. Nicoloro, Shinya U. Amano, Jessica L. Cohen, and Michael P. Czech
The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans, Gabriel D. Bosse, Stefan Ruegger, Maria C. Ow, Alejandro Vasquez-Rifo, Evelyne L. Rondeau, Victor R. Ambros, Helge Grosshans, and Martin J. Simard
Humanized mice for the study of infectious diseases, Michael A. Brehm, Nathalie Jouvet, Dale L. Greiner, and Leonard D. Shultz
Resurrecting remnants: the lives of post-mitotic midbodies, Chun-Ting Chen, Andreas W. Ettinger, Wieland B. Huttner, and Stephen J. Doxsey
Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila, Wei Cheng, Y. Tony Ip, and Zuoshang Xu
Hdac6 regulates Tip60-p400 function in stem cells, Poshen B. Chen, Jui-Hung Hung, Taylor L. Hickman, Andrew H. Coles, James F. Carey, Zhiping Weng, Feixia Chu, and Thomas G. Fazzio
p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells, Ya-Wen Chen, Hsiao-Chien Chu, Ze-Shiang Lin, Wei-Jyh Shiah, Chen-Pin Chou, David S. Klimstra, and Brian C. Lewis
Novel strategies to enhance vaccine immunity against coccidioidomycosis, Garry T. Cole, Chiung-Yu Hung, Sam D. Sanderson, Brady J. Hurtgen, Marcel Wuthrich, Bruce S. Klein, George S. Deepe, Gary R. Ostroff, and Stuart M. Levitz
Obesity Notches up fatty liver, Michael P. Czech
Insulin signalling mechanisms for triacylglycerol storage, Michael P. Czech, Michaela Tencerova, David J. Pedersen, and Myriam Aouadi
Translational control of cell growth and malignancy by the CPEBs, Andrea D'Ambrogio, Kentaro Nagaoka, and Joel D. Richter
Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling, Laura V. Danai, Adilson L. Guilherme, Kalyani V. P. Guntur, Juerg R. Straubhaar, Sarah M. Nicoloro, and Michael P. Czech
TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm, Alberto De Iaco, Federico A. Santoni, Anne Vannier, Michel Guipponi, Stylianos E. Antonarakis, and Jeremy Luban
Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants, Metewo Selase Enuameh, Yuna Asriyan, Adam Richards, Ryan G. Christensen, Victoria L. Hall, Majid Kazemian, Cong Zhu, Hannah Pham, Qiong Cheng, Charles Blatti, Jessie A. Brasefield, Matthew D. Basciotta, Jianhong Ou, Joseph C. McNulty, Lihua Julie Zhu, Susan E. Celniker, Saurabh Sinha, Gary D. Stormo, Michael H. Brodsky, and Scot A. Wolfe
Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosa, Elif Eren, Jamie Parkin, Ayodele Adelanwa, Belete R. Cheneke, Liviu Movileanu, Syma Khalid, and Bert Van den Berg
MEN1 is a Melanoma Tumor Suppressor that Preserves Genomic Integrity by Stimulating Transcription of Genes that Promote Homologous Recombination-Directed DNA Repair, Minggang Fang, Fen Xia, Meera Mahalingam, Ching-Man A. Virbasius, Narendra Wajapeyee, and Michael R. Green
Analysis of ciliary membrane protein dynamics using SNAP technology, John A. Follit and Gregory J. Pazour
Using networks to measure similarity between genes: association index selection, Juan I. Fuxman Bass, Alos Diallo, Justin Nelson, Juan M. Soto, Chad L. Myers, and Albertha J. M. Walhout
GLI1 regulates a novel neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation, Hira Lal Goel, Bryan M. Pursell, Cheng Chang, Leslie M. Shaw, Junhao Mao, Karl Simin, Prashant Kumar, Craig W. Vander Kooi, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Charlotte Kuperwasser, and Arthur M. Mercurio
beta1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase1, Hira Lal Goel, Aejaz Sayeed, Michael Breen, Matthew J. Zarif, David S. Garlick, Irwin Leav, Roger J. Davis, Thomas J. Fitzgerald, Andea Morrione, Chung-Cheng Hsieh, Qin Liu, Adam P. Dicker, Dario C. Altieri, and Lucia R. Languino
Targeted chromosomal deletions and inversions in zebrafish, Ankit Gupta, Victoria L. Hall, Fatma O. Kok, Masahiro Shin, Joseph C. McNulty, Nathan D. Lawson, and Scot A. Wolfe
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation, Myoung Souk Han, Dae Young Jung, Caroline Morel, Saquib A. Lakhani, Jason K. Kim, Richard A. Flavell, and Roger J. Davis
One among many: ODF2 isoform 9, a.k.a. Cenexin-1, is required for ciliogenesis, Heidi Hehnly, Hui-Fan Hung, and Stephen J. Doxsey
Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice, Eun-Gyoung Hong, Brian W. Kim, Dae Young Jung, Jong Hun Kim, Tim Yu, Wagner Seixas Da Silva, Randall H. Friedline, Suzy D. Bianco, Stephen P. Seslar, Hiroko Wakimoto, Charles I. Berul, Kerry S. Russell, Ki Won Lee, P. Reed Larsen, Antonio C. Bianco, and Jason K. Kim
Epigenetics in the human brain, Isaac B. Houston, Cyril J. Peter, Amanda C. Mitchell, Juerg R. Straubhaar, Evgeny I. Rogaev, and Schahram Akbarian
Characterization and optimization of the glucan particle-based vaccine platform, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz
Inductive asymmetric cell division: The WRM leads the way, Takao Ishidate, Soyoung Kim, Craig C. Mello, and Masaki Shirayama
U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs, Jermaine L. Jenkins, Anant A. Agrawal, Ankit Gupta, Michael R. Green, and Clara L. Kielkopf
Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleo-cytoplasmic shuttling, Baowei Jiao, Naoko Taniguchi-Ishigaki, Cenap Gungor, Marvin A. Peters, Ya-Wen Chen, Sabine Riethdorf, Alexander Drung, Leanne G. Ahronian, JongDae Shin, Rachna Pagnis, Klaus Pantel, Taro Tachibana, Brian C. Lewis, Steven A. Johnsen, and Ingolf Bach
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes, Tony Jourdan, Grzegorz Godlewski, Resat Cinar, Adeline Bertola, Gergo Szanda, Jie Liu, Joseph Tam, Tiffany Han, Bani Mukhopadhyay, Monica C. Skarulis, Cynthia Ju, Myriam Aouadi, Michael P. Czech, and George Kunos
KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance, Dae Young Jung, UmaDevi Chalasani, Ning Pan, Randall H. Friedline, Domenick A. Prosdocimo, Minwoo Nam, Yoshihiro Azuma, Rajanikanth Maganti, Kristine Yu, Ashish Velagapudi, Bryan O'Sullivan-Murphy, Juliano L. Sartoretto, Mukesh K. Jain, Marcus P. Cooper, Fumihiko Urano, Jason K. Kim, and Susan Gray
Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity, Shashi Kant, Tamera Barrett, Anastassiia Vertii, Yun Hee Noh, Dae Young Jung, Jason K. Kim, and Roger J. Davis
Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development, Majid Kazemian, Hannah Pham, Scot A. Wolfe, Michael H. Brodsky, and Saurabh Sinha
Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules, Nicola A. Kearns, Ryan M. J. Genga, Michael Ziller, Kristina Kapinas, Heiko Peters, Michael A. Brehm, Alexander Meissner, and Rene Maehr
Wnt and CDK-1 regulate cortical release of WRM-1/beta-catenin to control cell division orientation in early Caenorhabditis elegans embryos, Soyoung Kim, Takao Ishidate, Rita Sharma, Martha C. Soto, Darryl Conte Jr., Craig C. Mello, and Masaki Shirayama
Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice, Jinhee Lee, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, and Hardy Kornfeld


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News & Announcements
Principal's Message
I'll be seeing you
Attention All Visitors to MRHS
Effective immediately all visitors to MRHS will need to produce valid photo identification prior to entering the building.
Transportation Memo Papers Summer 2015 (pdf)
Payforit Mobile is Live Click Here for Details (pdf)
Dates to Remember:
Upcoming Highlighted Events. Please check often to stay up-to-date on upcoming events.
Click here for the Fact Sheet for Parents - Sports Related Eye Injuries in Youth (pdf)
Click here for information on the School Board Candidate Nominating Petitions (pdf)
Updating Your Honeywell Alerts
Dear Parents,
In an effort to keep you informed of news and events occurring at Monmouth Regional, we will be using the Honeywell Instant Alert system more frequently.
Video About MRHS
A quick tour and general information of Monmouth Regional HS.
Click Here For Varsity Jacket Order Info (pdf)
Information regarding purchasing a MRHS Varsity Jacket.
Information on MRHS Security Drills (pdf)
Guidance Department Overview (pdf)
MRHS Philosophy and Mission Statement (pdf)
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Product Specs
Product Description
These stylish Ferdinand mugs are the perfect gift for groomsmen who enjoy a good beer. Ideal for beers on tap, lagers, and specialty beers, this mug is secured with a sturdy handle and a wide base to prevent spills. Personalize this mug for an added special touch.


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Camp Hometown Heroes serves relatives of service members who died
Children, nieces, nephews and younger siblings of U.S. service members who died in any manner are invited to Camp Hometown Heroes, a overnight camp June 22 through 28 at YMCA Camp Malawa in Campbellsport.
The camp, founded by Kapco Metal Stamping and its nonprofit partner the volunteer organization Hometown Heroes, is for children ages 7 to 16 and will offer traditional camp activities but will include guidance from pediatric grief specialists. »Read Full Article
Purple Door Ice Cream will open new store in Walker's Point
Journal Sentinel file photo »Read Full Blog Post(1)
Sequel doesn't bother trying to be inventive — or interesting
When a movie's official website is called smurfhappens.com, it might be considered a fair warning about its quality. Actually, "The Smurfs 2" is not that bad, but it's definitely not going to rise to the top of the summer kids-movie heap.
In this sequel to 2011's "The Smurfs," opening in theaters Wednesday, Smurfette (voiced by Katy Perry) is questioning her identity and worrying she will turn back into the evil anti-Smurf she was created to be by the wizard Gargamel (Hank Azaria). »Read Full Article(1)
Refuge Smoothie Cafe opening Aug. 5 on Plankinton
It had planned to open on the east side first, but Refuge Smoothie Cafe will open its first shop downtown, at 763 N. Plankinton Ave. on Aug. 5.
Joshua Janis, who also owns the Red Rock Saloon and McGillycuddy's on Water St., said he still plans to open a Refuge cafe at 2328 N. Farwell Ave., but the site is having construction delays. »Read Full Blog Post
Time Warner to meet with state Senate president over Journal Broadcast
Time Warner Cable has requested a meeting with state Senate President Mike Ellis (R-Neenah) in response to his request that cable customers receive rebates in the blackout of Journal Broadcast Group stations.
Ellis and a Time Warner representative will meet this afternoon, according to an Ellis aide. »Read Full Blog Post(17)
'This Town' depicts Paul Ryan as shrewd, with a sense of humor
'This Town' (Blue Rider Press), Mark Leibovich's new book on the clubby, clannish ecosystem of Washington, skewers many self-important political, lobbyist and media figures. But the Wisconsinite who figures most prominently in the book, former vice-presidential candidate Rep. Paul Ryan, gets off lightly. (Harry Reid, Trent Lott and Politico, to name just three, do not get off so easily.) »Read Full Blog Post(3)
Does Journal Broadcast blackout hinge on Time Warner negotiations with CBS?
As the blackout of Journal Broadcast Group stations, including WTMJ-TV (Channel 4), on Time Warner Cable approaches its first-week anniversary, I submit the possible reason:
The cable company is distracted — perhaps obsessed — with first reaching an agreement in its similar dispute with CBS network-owned and -operated stations. »Read Full Blog Post(15)
Tourism ad starring Packers' Jordy Nelson gets theater premiere
A new Wisconsin Tourism commercial starring Packers wide receiver Jordy Nelson will premiere at 5 p.m. Thursday at the Meyer Theatre in Green Bay.
The commercial was directed by Shorewood native Jerry Zucker, who directed the "Airplane!" and "Naked Gun" series, among other films, the Green Bay Press-Gazette reports. »Read Full Article
On Tap Today: Old School New Wave
Wang Chung and The Fixx. Those are a couple of band names music fans of a certain age might not have heard for a very, very long time.
The British bands, more successful in the U.S. than their homeland, had a string of singles, including two in particular, Chung's "Everybody Have Fun Tonight" and Fixx's "One Thing Leads to Another," that fall on a relatively small list of songs that instantly symboize the decade. »Read Full Blog Post


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NASA Earth and Space Science Fellowship (NESSF)
The NASA Earth Science Research Program, managed by the Earth Science Division of the Science Mission Directorate, fulfills NASA's mission to drive advances in science, technology, aeronautics, and space exploration to enhance knowledge, education, innovation, economic vitality, and stewardship of Earth (see NASA 2014 Strategic Plan at http://science.nasa.gov/about-us/science-strategy/) and, in particular, the strategic objective 2.2, to advance knowledge of Earth as a system to meet the challenges of environmental change, and to improve life on our planet. This strategic objective is motivated by the following key questions:
- How is the global Earth system changing?
- What causes these changes in the Earth system?
- How will the Earth system change in the future?
- How can Earth system science provide societal benefit?
The NASA Earth and Space Science Fellowship (NESSF) supports basic and applied research in Earth and space science. Approximately 50 new graduate fellowships in Earth Science are awarded each year.
The Science Goals to guide the Earth Science Division's selection are:
- Atmospheric Composition
- Weather
- Carbon Cycle and Ecosystems
- Water and Energy Cycle
- Climate Variability and Change
- Earth Surface and Interior
- Further the use of Earth system science researcg to inform decisions and provide benefits to society
The award amount is up to $30,000 per year with awards made initially for one year and may be renewed for no more than two additional years.
The application requires a cover page, a 6-page proposed research project, a research schedule, signed letter of recommendation from Advisor, and transcripts.
Deadline for New applications: 11:59PM EST, Feb. 2, 2015
Deadline for Renewal applications: 11:59PM EST, March 16, 2015


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More New and Used
from Private Sellers
Insourced : How Importing Jobs Impacts the Healthcare Crisis Here and Abroadby Tulenko, Kate
Questions About This Book?
What version or edition is this?
This is the 1st edition with a publication date of 5/1/2012.
What is included with this book?
- The eBook copy of this book is not guaranteed to include any supplemental materials. Typically only the book itself is included.
For years, opponents of outsourcing have argued that offshoring American jobs destroys our local industries, lays waste to American job creation, and gives foreigners the good jobs and income that would otherwise remain on our shores. Yet few Americans realize that a parallel dynamic is occurring in the healthcare sector--previously one of the most consistent sources of stable, dependable living-wage jobs in the entire nation. Instead of outsourcing high-paying jobs overseas--as the manufacturing and service sectors do--hospitals and other healthcare companies insource healthcare labor from developing countries, giving the jobs to people who are willing to accept lower pay and worse working conditions than U.S. healthcare workers. As Dr. Tulenko shows, insourcing has caused tens of thousands of high-paying local jobs in the healthcare sector to effectively vanish from the reach of U.S. citizens, weakened the healthcare systems of developing nations, and constricted the U.S. health professional education system. She warns Americans about what she's seeing--a stunning story they're scarcely aware of, which impacts all of us directly and measurably--and describes how to create better American health professional education, more high-paying healthcare jobs, and improved health for the poor in the developing world.
Table of Contents
|p. ix
|p. xiii
|p. xxv
|p. 1
|Shortage in the Land of Abundance
|p. 10
|How the United States Created its Healthcare-Workforce Problem
|p. 40
|The Path to America
|p. 66
|The Damage Done
|p. 91
|The Fox and the Hydra Failed Attempts to Address-Insourcing
|p. 116
|Successful Efforts to Curb Insourcing
|p. 138
|The Way Forward
|p. 150
|p. 181
|p. 197
|Table of Contents provided by Ingram. All Rights Reserved.


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We welcome you to our Handelshof Restaurant and Jimmy's Bar.
Go Healthy and enjoy seasonal, vitamin rich, and low-calorie dishes prepared with fresh ingredients. Learn more
Restaurant and Bar
At our Handelshof Restaurant, you can expect, alongside classic dishes, a variety of Swiss culinary treats as well as international specialities. The Handelshof Restaurant opens Monday until Friday from 6.30 am until 11.00 pm and on Saturdays from 6.30 am until 12.30 pm as well as from 3.00 pm until 11.00 pm. On Sundays and bank holidays our restaurant opens from 6.30 am until 12.30 pm.
Enjoy a drink in the atmosphere of an English pub at Jimmy's Bar. Perfect for pre- or after-dinner drinks. Jimmy's Bar offers more than 80 different whiskey labels as well as a wide variety of other spirits, cocktails and soft drinks.
You can also take part in one of our exclusive culinary events.
Breakfast Offer
Start the day with our daily Gourmet Breakfast Buffet with an original Swiss Bircher Muesli, yoghurt, quark, fresh fruits, fruit salad, cereals, nuts, dried fruits, rolls, bread, croissants, sweet pastries, jam, honey, freshly prepared egg dishes, little sausages, bacon, assorted cold cuts and cheese, smoked fish, mineral water, a variety of juices and hot drinks.
Our breakfast buffet takes place from 6.30 am to 10.30 am for EUR 20.00 per person. On weekends and holidays you will enjoy our breakfast buffet until 12.30 pm.


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I'm a developer, from the front-end to the back. I have a well-rounded education of many different web and software languages, though I have an advanced proficiency of front-end techniques. Some of my favorite aspects of development are optimizing code, fixing details, and finding bugs. I'm an independent person, but I enjoy the learning opportunities afforded by working on a team. Did I mention I have a fine arts degree? I'd love the chance to explain why I think all developers can benefit from an arts curriculum.
As the only designer/developer/analyst on staff, my job is to maintain our entire web presence. We started with an .NET-backed website, but one of my first projects was to oversee the redesign of ExploreAsheville.com with a new company that worked primarily in Coldfusion, and I've since updated and maintained it as the web evolves, as well as creating the matching mobile site and Blogger theme. The site will receive over 4 million visits this year. I've been in charge of creating all print- and web-related assets for our various marketing campaigns, all of the digital analytics, and two long-form, media-rich, interactive stories that continue to win awards. Finally, we're in the process of a second redesign utilizing Node.js and MongoDB. One feature of our new site utilizes web-scraping technology written in Python that we'll be using to partner with area online events calendars to create a single, unified events calendar for the entire county.
Asheville, North Carolina
2010-late 2010
During my time at Houser Shoes, I was part of a 3-person team that redesigned their e-commerce website. We created a custom CMS based on Magento, which utilized primarily PHP and MySQL. I also have a photography education, which made me the de-facto product photographer.
Fletcher, North Carolina
Immediately after graduation, I began freelancing. It was mostly branding and identity at first, but I eventually had enough clients needing new websites that I was putting in more hours than most full-time web developers. I still enjoy creating websites for friends from time-to-time. Asheville, North Carolina
Though this isn't programming- or web-related, I still think my experience working in a print shop can be seen in my work as a developer. On the web, mistakes can be fixed and I think, unfortunately, that mentality is common among developers and leads to sloppy code. Printing, however, requires an extremely detail-oriented approach as there is no room for error. As an example, Appalachian State University was one of our clients, so projects like the designing and printing of 20,000-30,000 graduation programs required efficiency and communication among all members of our team to ensure we weren't making mistakes that would cost us hundreds of thousands of dollars. Boone, North Carolina
During my time, I worked with an intern to establish an online presence for The Appalachian newspaper, while still maintaining my role as the lead graphic designer.
Boone, North Carolina
I chose to study graphic design in the Fine Arts department of Appalachian State. I already had a grasp on web and software development and continued to teach myself during this time, but studying design in an art department allowed me to learn other aspects of development that are equally as important as the tools and languages themselves. The curriculum path I chose focused on web development while also teaching color theory, typography, and layout design in a group setting. I think all developers should have an eye for design, and I believe having this well-rounded education makes me a unique candidate for a position at any company. Outside of web design, we also had the opportunity to learn Actionscript game development. It was here that I learned the importance of architecture, specifically the model-view-controller pattern. Boone, North Carolina
Why would I add high school to this list? Because this is when I started my development career, 15 years ago. I built my first website with PHP, HTML, CSS, and JavaScript in 2000 and started with C++ shortly thereafter. It was here that I learned the conventions behind object-oriented programming. Asheville, North Carolina


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Reasons to reject Yankee bidNovember 29,2012The Public Service Board is holding hearings around Vermont seeking input for their docket on whether or not to grant Vermont Yankee nuclear power plant a new certificate of public good to continue operating. The PSB should deny Vermont Yankee a new certificate for the following reasons.
We cannot count on the Nuclear Regulatory Commission to look out for our public good. Historically, it has proven to be 1) of the nuclear industry, 2) by the nuclear industry, and 3) for the nuclear industry.
Nor can we count on Vermont Yankees parent, Louisiana-based Entergy, to look out for our public good. Entergys fiduciary responsibility is to make decisions that benefit their shareholders. This has meant deferring maintenance, postponing major equipment replacements and ignoring the rising but impending costs of decommissioning. Entergy subsequently filed suits against the state of Vermont and the Public Service Board to try to reverse a decision they had previously agreed to and demanding that Vermont taxpayers cover their legal fees.
We cannot count on Vermont Yankee to enhance our public good since they have not even proposed a competitive energy price acceptable to our utilities.
We have counted on the Vermont Legislature, and the Vermont Senate examined closely Entergys corporate record. The Senate deemed that record was not conducive to the public good and, reflecting the expressed will of the majority of Vermonters, voted to reject PSB approval of a certificate of public good for Vermont Yankee.
We could not count on the courts to look out for Vermonts public good. Federal Judge Gavin Murthas pro-Vermont Yankee decision in the case Entergy brought against the state was based on inference what Entergy said the legislators were thinking when they voted rather than on the written legislative record. Murthas decision is being appealed, but meanwhile Murtha returned the certificate decision back to the PSB hence, the PSB docket and public hearings.
I ask the PSB to value the constitutional concept of states rights and respect the Vermont legislative decisions; examine the history of Entergys corporate behavior; and following the precepts of its own mission statement, deny Vermont Yankee a new certificate of public good.
SpringfieldMORE IN LettersThe first thing that makes racism ludicrous is that no person on this Earth has ever chosen their... Full StoryI seem to have hit a nerve. Mr. Full StoryWith a fervid interest I have been following the plight of a Christ the King School student who... Full Story
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- RICHARD'S POOR ALMANACK: On this day in 1472, Orkney, Shetland islands put up as collateral by Norway to Scotland in lieu of dowry for MARGARET OF DENMARK on her marriage with JAMES III, king of Scotland; 1962, JOHN GLENN first American to orbit Earth.
- TOMORROW'S HEADLINES TODAY: City mayoral candidates debate campaign issues; Hartford, Conn., woman still missing; Neal Goswami reports attempts to legislate suicide; local woman loses 100 pounds through TOPS program.
- RICHARD'S POOR ALMANACK: On this day in 1878, JOHN TUNSTALL murdered near Lincoln, New Mexico, by the outlaw JESSE EVANS; in 1930, ELM FARM OLLIE first cow to fly in aircraft, first to be milked airborne; 1955, nuke test WASP; '79, snow in Sahara.
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- RICHARD'S POOR ALMANACK: On this day in 1249 AD, ANDRE of LONGJUMEAU is dispatched by LOUIS IX of France to meet the KHAGAN, ruler of the Mongol Empire; in 1804, during 1st Barbary War, STEPHEN DECATUR scuttles the pirate-held USS Philadelphia in Tripoli.


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|Jul 7 2015
Metro Councilmembers Announce Upcoming Performance of Friday Fest Concert at Highview Park
For Immediate Release
|Jul 7 2015
First Neighborhood Place Grand Reopening Celebration
After 21 years of serving the community, First Neighborhood Place has a new, refreshed look. On Wednesday, July 8, 2015 local officials, Neighborhood Place partners and members of the community will join together for a rededication celebration at 11 a.m., 1503 Rangeland Road.
Renovations include new carpet, paint and furniture along with a Family Store giving staff and clients a sense of pride.
|Jul 7 2015
Councilman Hollander announces monthly "Meet with Bill" set for Wednesday, July 15th
Louisville – Councilman Bill Hollander is encouraging District 9 residents to come out for the monthly "Meet with Bill" set for Wednesday, July 15th at the Crescent Hill Library, 2762 Frankfort Avenue.
"This is one way I make myself available to constituents of District 9 so they can tell me what's on their mind," says Hollander.
The Councilman will be available at the Crescent Hill Library from 2:00pm to 4:00pm.
|Jul 6 2015
Neighborhood Place Partners Offer Six Back to School Events, Two Job Search Series and More
Neighborhood Place sites in Louisville will offer six back to school events in July and early August, plus free educational workshops to benefit the entire family including a job search series, several educational baby showers, three couponing classes plus much more. To learn more about these services, including reservations requirements and contact info, please refer to the phone numbers listed by each event.
|Jul 6 2015
Old-Fashioned Ice Cream Social – July 12 At Riverside, the Farnsley-Moremen Landing
The entire family is invited to enjoy a day of fun on the banks of the Ohio River as Riverside, the Farnsley-Moremen Landing hosts an "Old-Fashioned Ice Cream Social", Sunday, July 12 from 1-5 p.m. The historic property is located at 7410 Moorman Road.


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Maybe it's bc I'm newer to birth works but when I get an inquiry, I try to call or email back within a few hours. It just seems like the polite thing to do and better for business. But now I'm on the other side of things, calling mws and doulas for myself, and very few return my calls. I don't mean several days before I hear from someone, I mean not at all or many months down the line. Is this typical?
Loving mama to ds C (6/07) and dd N (11/08). Joyously welcomed our , dd2 A (8/11).
I think that is a-typical... I personally return calls ASAP, and expect the same.
Mama to and
Unless I am at a birth, I return calls within a few hours.
Midwife (CPM, LDM) and homeschooling mama to:
14yo ds 11yo dd 9yo ds and 7yo ds and 2yo ds
I get many of my contacts via email, and if it's a simple inquiry I respond ASAP. I return calls during office hours, which may not be every day.
Most of my contacts come from the contact sheet on my website, and I try to email ASAP, which is usually within a few hours. If someone wants to speak with me on the phone then I try to arrange something the next day at a specified time of day, usually nap time.
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Inter Milan, a Serie A powerhouse that has fallen on hard times recently, is a team with everything to prove and will be coming to the United States later this month to compete in the 2013 International Champions Cup. Here's … Continue reading
European action takes center stage next week, as next week will mark the halfway point of the group stage of the Champions League. While there is much to be decided between now and the last round of group stage fixtures … Continue reading
The first legs of the quarter-finals saw 3 of 4 matches end with large advantages being established. The fixture that all the attention will be focused on this week will be the second leg match between Manchester United FC and … Continue reading
The penultimate matchday of the Champions League group stages is coming up, and it's make-or-break time for some big clubs. These midweek matches could even decide the future for some coaches, like Rafa Benitez at Inter Milan, who's been getting … Continue reading
Under Jose Mourinho, Inter gradually developed an aura of invincibility, and their defence – generally made up of Maicon, Lucio, Samuel and Chivu (or Zanetti) – had become the envy of the rest of Europe. The Nerazzurri had finally brought … Continue reading
With the another matchday of the Champions/Europa League group stages coming up, I've decided to take a look at what could be the more interesting matches of the 40 which will be played in the two competitions. The way I've … Continue reading
Real Madrid has continued their massive summer overhaul and some big names will feature in new colors for the upcoming season. No longer wearing the famous white shirt of Madrid will be Dutch national teammates Arjen Robben and Wesley . … Continue reading
The story that generated the most headlines outside of the Kaka to Manchester City, was the saga of Robbie Keane's departure from Liverpool back to Tottenham. Keane made his "dream move" to Liverpool this past summer when the club splashed … Continue reading
(photo courtesy of uefa.com) Wow. There are some really great match-ups that have emerged from today's draw at UEFA headquarters. I'm going to give a quick rundown and early predictions though I reserve the right to change my mind before … Continue reading
There are some pivotal battles to be fought in the upcoming Matchday and while some groups look to have clear patterns emerging, others could go down to the wire. Let's take a whirlwind tour of the current state of the … Continue reading
Matchday 4 should be a pivotal one as many groups may well be decided once the games are completed. Who needs a win and who can afford to slip? Let's take a look at Tuesday's games. Group A Roma need … Continue reading
Champions League debutants CFR 1907 Cluj came from behind to beat Roma and record a stunning 2-1 victory at the Stadio Olimpico in Rome. Beyond the absence of Totti, Roma had a strong squad out on the field and will … Continue reading
Group B is home to a surprising Cypriot side, a Greek side in transition, a German side sometimes called 'everyone's second team', and an Italian club with a little something special. Confused? Let me explain! Anorthosis Famagusta FC How They … Continue reading
One of the most fascinating moves this summer was Internazionale's hiring of Jose Mourinho as manager after Roberto Mancini was sacked despite winning the title. Mourinho has built a strong reputation in a short time and I am interested to … Continue reading
ESPN reports that Internazionale have fired manager Roberto Mancini after much speculation that they were going to do so. Comments Mancini made after losing to Liverpool in the last 16 of the Champions League in March were cited as a … Continue reading
As we wait for the Champions League final, it's a good time to look at the leagues around Europe and see who will be part of next season's competition. In this first report, we look at what I would call … Continue reading
Barcelona's Ronaldinho has reportedly agreed initial terms with Italian giants AC Milan, according to his brother and agent Roberto de Assis. Ronaldinho is out of action for the rest of the season with injury but is said to be disillusioned … Continue reading
As I speculated on in an earlier post, it seems that Roberto Mancini's "I'm leaving…wait…no I'm staying" routine has contributed to Inter's shocking decline of form. The announcement was made moments after Inter had been dumped out of the Champions … Continue reading


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Oregon's sophomore running back is up for the Maxwell Award, which Marcus Mariota won for 2014, and "DeFo" has a shot at the Bednarik.
Joe Bernardi, who enters his third and final year as a graduate assistant this fall, went on the road in place of Steve Greatwood in May.
Quarterback Marcus Mariota and outfielder Janie Takeda were named Oregon's top seniors for 2014-15 by the Pac-12 Conference.
After opening the decade by meeting for the BCS national championship, the Ducks and Tigers will close it out in their 2019 season opener.
The Oregon football program welcomed a host of newcomers for the start of summer school and offseason workouts this week.
Marcus Mariota, Cheridan Hawkins and Mark Helfrich were among winners from UO at the state-wide Oregon Sports Awards on Thursday.
5 p.m. start for Duck's season opener vs. Eastern Washington among five kickoff times announced for the upcoming 2015 football season
Bralon Addison returned to action for Saturday's Spring Game, and showed off his skills both as a receiver and a passer.
Cornerback Ifo Ekpre-Olomu was selected in the final round of the NFL draft Saturday, giving the Ducks five players selected this year.
Oregon provided an entertaining conclusion to spring drills and also honored U.S. service personnel during Saturday's Spring Game.
Junior quarterback Jeff Lockie went 9-of-9 for 223 yards and three touchdowns in Saturday's Spring Game, capping a strong month of practice.
Sophomore Charles Nelson moved from receiver to cornerback this offseason, but in Saturday's Spring Game he was up to old tricks.


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The Kentucky baseball team will wrap up its home schedule this weekend, playing host to Auburn in a three-game series, with first pitch in the series opener on Friday slated for 6:30 p.m. ET at Cliff Hagan Stadium. The series will resume on Saturday at 7 p.m. ET and conclude on Sunday at 1 p.m. ET at Cliff Hagan Stadium.
Click here for the original story.
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Jeff Danos has been crafting experimental electronic music since 1994. He enjoys creating order out of chaos, regardless of genre. Approaching each new musical release as an experiment in sound, he fuses atypical idm, industrial, glitch, and ambient textures into complex cohesive compositions...which is a fancy way of saying that he has a knack for making strange and experimental music somehow more palatable.
Atavistic EP just released!
Submitted by jeff on April 6, 2015 - 10:57am
Filed Under:
Very excited and relieved to announce that the new Testube EP Atavistic has just been released! It has been a long and hard road to completion with this one, due not only to time constraints and technical challenges, but also adjusting to a new off-grid studio space. As the title suggests, the release is something of a "throwback" to my roots. From the raw accordion intro (yeah, that's right..accordion!) to the old school breakin' electro sound of the track "Bleeds More Cowbell", these tunes are the mutant bastard offspring of a glitch-inspired digital tinkerer and his inner analog demons. Hope you dig it!
New Testube EP coming soon!
Submitted by jeff on February 10, 2015 - 6:04pm
Filed Under:
I'm putting the finishing touches on a new Testube EP, which will feature 4 or 5 new tracks and will be titled "Atavistic". Here's a preview demo track called "Gater" at Soundcloud:
Testube to deejay Dance of the Dead 2014
Submitted by jeff on October 29, 2014 - 11:27pm
Filed Under:
I will be deejaying this Saturday night from 8pm to 10pm at the Dance of the Dead, the official after-party for the Third Annual Eureka Springs Zombie Crawl. The party is located at Melonlight Studio this year, and admission is only $5 per person. BYOB, no kids under 16 without their parents. If you are in the area, I hope to see you there!


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You can now invite anyone to meet at your favorite Starbucks.
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24 year old man | East Point, GA, USA | Seeking women 18-21 within 10 miles of Seattle, WA
Travelling is everyone's passion
I am a student, I work part time as a customer service agent. I'm actually new to the Seattle area, I live in an apartment with 2 other roommates. I am central american, my parents are from Nicaragua. So.. I LOVE traveling, especially because its free for me, I love meeting people from all over the world! One of the reasons why I came here to live was because I enjoy nature, my perfect day off from work is taking a walk at the beach, go hiking, read a book at the park, and go to social events, and go to touristy spots! I'm pretty much a chill guy, I dont really drink, nor smoke. I love FOOD! So im hoping to find a girl who likes to go restaurant hopping :) Basically what I am looking for is a girlfriend, and a bestfriend. Someone who makes me happy, I want to meet a lady who loves doing the same thing I do. She must love to travel, and if shes lucky, I might just put her as my travel companion on my flight benefits... I want a sweet girl.
Camping , Coffee and conversation , Dining out , Fishing/Hunting , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Playing sports , Travel/Sightseeing , Volunteering , Watching sports
Baseball, Running, Walking / Hiking
I exercise 1-2 times per week.
I have Dogs, Exotic Pets, Other
Alki Beach, Gas works Park, Mount Rainier, Mount st.Helen, so far this is all ive seen, since I've only been living in Seattle for 2 weeks.
Seattle Central Community College, Seattle, WA
I love christian music, but I enjoy anything. I am also a huge baseball fan, so I hope to find someone that likes going to baseball games! concerts are a must...
I like going to Alki Beach and read a book, I like to run on my off days, alot. Most of time I am traveling out of the country exploring new things! I like going to the movies, concerts, hiking, kayaking.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'8" (172cms)
|5'4" (162cms) to 5'8" (172cms)
|Body type:
|About average
|Slender, About average
|Black, Blue, Brown, Grey, Green, Hazel
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way
|I'll tell you later
|Never, Social Drinker
|Travel / Hospitality / Transportation
|No preference
I have been working for 2 years now. I am a customer service agent so i'm part of the crew you first talk to when you check in to a flight, or when we let you board the plane, yes.
|Less Than $25,000
|No preference
|Never Married
|Never Married
|Have kids:
|Yes, and they sometimes live at home, No, Yes, and they live at home
|Wants kids:
|Definitely, Someday, Not sure
|Latino / Hispanic
|Latino / Hispanic, White / Caucasian
|I'll tell you later
|No preference
|English, Spanish
|No preference
|Some college
|High school, Some college
I graduated from Rialto High School, in california. I then took a very long break to work, and now I am a community college going towards my computer science degree.


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There are no games scheduled for Sunday, Dec 30.
Corban U 49
Boise State 105
(10-2, 6-0 home)
4:00 PM ET, December 30, 2012
Taco Bell Arena, Boise, Idaho
Top Performers
Corban University: J. Sebens 12 Pts, 2 Reb, 1 Ast
Boise State: K. Buckner 23 Pts, 10 Reb, 2 Ast
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Nov. 3 (Bloomberg) -- Leucadia National Corp., the largest investor in Jefferies Group Inc., fell as the value of the stake in the investment bank plunged.
Leucadia, also an investor in mortgages, vineyards and mining, dropped 7 percent to $24.08 at 10:37 a.m. in New York. New York-based Leucadia, which holds a 28 percent stake in Jefferies, has plunged about 15 percent this week on concern the investment bank could be pressured by Europe's financial crisis. Jefferies has dropped more than 20 percent since Oct. 28.
Laura Ulbrandt, a spokeswoman for Leucadia, declined to comment.
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Time To Put Down Her Labors
It's been one great career for Yvonne Layton over in Chester, & tomorrow, on Wednesday, the Farm Service Agency in Chester will be hosting an open house to CELEBRATE Yvonne's retirement! Tomorrow's open house at the Farm Service Agency will be from 1 until 4 in the afternoon. Pl


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Updated 02/25/2014
Chef Andrew Carmellini, an acolyte of Daniel Boulud, has definitely made a name for himself in New York City with this Robert De Niro–backed restaurant, and then with the Dutch in SoHo. The space at Locanda Verde is warm and welcoming, with accents of brick and wood and large windows that open to the street, weather permitting, while the menu is full of inspired Italian comfort food that hits the mark. Standouts include small plates like blue crab crostino with jalapeños and the pumpkin agnolotti in brown sage butter that diners reminisce about. Several draft beers, along with more than a dozen wines by the glass, make an already hopping bar scene even more of a draw.
377 Greenwich St., at N. Moore St., New York, New York, 10013, United States
Website: www.locandaverdenyc.com
Restaurant Details:
Updated 02/25/2014
By katie_f
Aug 9, 2013
I took my in-laws here while they were visiting and we had an incredible evening--every dish we tried was phenomenal, wine list is great, the interior is beautiful and the atmosphere lively. Don't miss the housemade ricotta! We didn't leave a drop left of the very generous portion... Do be sure to call ahead to get a good reservation--we ended up with quite early reservations only calling a two weeks ahead for a Saturday night.
By fluffnfold
Sep 17, 2012
My spouse and I ate Sunday brunch at Locanda Verde in mid-August 2012. It is one of the few New York restaurants that we have dined at that doesn't accept online reservations; however, it was easy to make a reservation by telephone. The restaurant called 2 days prior to reconfirm. The dress code (for Sunday brunch anyway) is casual. The restaurant appealed to us because their brunch menu featured items other than eggs and waffles (although they
served those, too). We started with a complimentary sample of their house-made focaccia bread, which was delicious. We then shared two appetizers – a goat's milk ricotta cheese topped with honey and served with super-thin slices of crusty bread which was one of the most unique dishes that we've eaten at a casual eatery (we would order that dish again as an appetizer; the portion size is large and can easily be shared by 3 to 4 people). Our other appetizer was steak tartare, which was traditionally presented for the most part, and served with toasted thin bread slices; the tartare was topped with an over-easy quail egg, which was a bit of a different element. We each ordered a pasta entrée – one beet raviolini (tiny ravioli in which the magenta of the beets showed through) served with olive oil and balsamic vinegar glaze (we didn't care for the vinegar component) and one spaghetti with Bolognese sauce (a dish that we loved and would order again if we were to return). For dessert, we shared the corn panna cotta, served with fresh raspberries and raspberry sorbetto – very delicious and unique (and again, something we would order again). The atmosphere is loud and busy and bustling, with an open kitchen. The tables aren't covered with tablecloths, so the noise is further magnified. We didn't find the chairs to be particularly comfortable; they had a very tight and narrow fit, which is how the tables felt at this restaurant as well – get to know your neighbors, and don't plan on having a conversation that you don't want to be overheard. (This isn't a romantic dinner spot in the least.) With a corner location, the restaurant has a good amount of outdoor sidewalk seating, although one side of the corner was under construction, so those sidewalk tables were shaded by scaffolding. We enjoyed our brunch here and might return again for a mid-day meal, but we don't know that we would return for dinner with so many other choices in the area. Although we are clearly in the minority with that sentiment – when we walked by this restaurant on a Saturday evening, it was the only restaurant in the area that was still lively and packed with people after 9:00 pm, and we also understand that it is one of the 10 hardest reservations to get in the city.
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ImmersiveTouch® is a leader in simulation based surgical training and exploration. ImmersiveTouch simulators 'immerse' surgeons in a digitally replicated operating environment with high-fidelity 3D virtual anatomies and haptic instrument replicates
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South Wales Evening Post list all of the sign makers in Swansea. If you are looking for sign makers in the local area then you can find a good business and deal with South Wales Evening Post!
Why not list your Swansea business on South Wales Evening Post?
Address: Unit 2 Minster Court, Valley Way, Swansea, SA6 8RN
Address: 1 Acorn Court, Clarion Close, Swansea Enterprise Park, SWANSEA, SA6 8QU
Address: 7 Cwmbath Road, , SWANSEA, SA6 7AU
Address: 85 Woodstock Gardens, Pencoed, Bridgend, CF35 6ST
Address: Unit 1.21 Dyfatty Park, , BURRY PORT, SA16 0FB
Address: Kemys Way, Swansea Enterprise Park, SWANSEA, SA6 8QF
Address: Unit 1 Red Dragon Garage, , Llandysul, SA44 5UQ
Address: Ashford House, Abergelli Road, Fforestfach, , Swansea, SA5 4DY
Address: Unit A1, Mardy Trading Estate, Gorseinon, SWANSEA, SA4 4HJ
Address: Panteg Villa, , LLANDEILO, SA19 6NP
Address: 11 Pontyglasdwr Street, , Swansea, SA1 2BH
Address: Abercych, , Boncath, SA37 0HA
Address: Unit 16 Tower Court, St Davids Road, SWANSEA, SA6 8RU
Address: Phoenix Way, Swansea Enterprise Park, SWANSEA, SA7 9EH
Address: 89 Tirmynydd Road, Three Crosses, SWANSEA, SA4 3PB


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The Sorcerer and the White Snake
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Watch The Sorcerer and the White Snake Online
Director:Siu-Tung ChingActors:Charlene Choi, Alfred Hsing, Vivian Hsu, Shengyi Huang, Wu Jiang(View All)
Description: Watch The Sorcerer and the White Snake full movie online for free directed by Siu-Tung Ching produced in 2013. Genres are Action, Fantasy.
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