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Charlotte Talks
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Wed December 19, 2007
Charlotte Talks
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The Funeral Industry The funeral industry in America has developed and changed quite a bit from the time of the first European settlers. We'll talk about how we say goodbye, revere, give dignity and honor to loved ones that we've lost, and talk with three funeral industry experts about how the "business" of funerals has evolved and how it's run today. Guests Sam James - Adjunct Professor of funeral services at Piedmont Technical College and Huntersville Funeral professional David Martin - Department Head at the SC College of Funeral Services at Piedmont Technical College Dedrick Grant - Professor at SC College of Funeral Services at Piedmont Technical College Contact the show: 704-926-9323, 800-603-9323 or email@example.com.


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Small bank in Ga. closed
WASHINGTON Regulators on Friday shut United Security Bank, a small bank in Georgia, bringing the number of bank failures this year to 116 amid the struggling economy and a cascade of defaults on loans.
The Federal Deposit Insurance Corp. took over United Security Bank, based in Sparta, Ga., with $157 million in assets and $150 million in deposits and two branches. Ameris Bank, based in Moultrie, Ga., agreed to assume the assets and deposits of the failed bank.
The failure of United Security Bank is expected to cost the federal deposit insurance fund an estimated $58 million.
With United Security, 21 Georgia banks have failed this year, more than in any other state. Most of the failures have involved banks in the Atlanta area, where the collapse of the real estate market brought economic dislocation. Failures also have been especially concentrated in California and Illinois.
As the economy has soured, with unemployment rising, home prices tumbling and loan defaults soaring, bank failures have cascaded and sapped billions out of the federal deposit insurance fund. It has fallen into the red.
Depositors' money – insured up to $250,000 per account – is not at risk, with the FDIC backed by the government. The FDIC still has billions in loss reserves apart from the insurance fund. It can also tap a Treasury Department credit line of up to $500 billion.
Last week, regulators shut nine banks – including California National Bank of Los Angeles, the fourth-largest failure this year with $7.8 billion in assets and 68 branches – owned by holding company FBOP Corp. It was a new milestone: nine was the highest number of banks closed in a day since the financial crisis began taking down banks last year. Minneapolis-based US Bancorp bought the deposits and most of the assets of the banks, which included two others in California, three in Texas, two in Illinois and one in Arizona.
Banks have been especially hurt by failed real estate loans. Banks that had lent to seemingly solid businesses are suffering losses as buildings sit vacant. As development projects collapse, builders are defaulting on their loans.
If the economic recovery falters, defaults on the high-risk loans could spike. Many regional banks, especially, hold large concentrations of these loans. Nearly $500 billion in commercial real estate loans are expected to come due annually over the next few years.
The 116 bank failures are the most in a year since 1992 at the height of the savings-and-loan crisis. They have cost the federal deposit insurance fund more than $27 billion so far this year, and hundreds more bank failures are expected to raise the cost to around $100 billion through 2013.
The number of banks on the FDIC's confidential "problem list" jumped to 416 at the end of June from 305 in the first quarter. That's the most since June 1994. About 13 percent of banks on the list generally end up failing, according to the FDIC.
The 116 failures this year compare with 25 last year and three in 2007.

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text: 'I Believe the Scientific Term Is Nubbin' Brian MoylanProfileFollowUnfollow Brian MoylanFiled to: open caption lady gaga Lady gaga's penis Gettypic 11/09/09 4:34pmEditDelete Invite manuallyPromoteXDismissXUndismissBlock for gawkerHideShare to KinjaShare to PinterestGo to permalink [Lady Gaga show the host of German talk show Wetten, dass...? just how big her penis really is. Image via Getty] 10Reply 10Discuss


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Hail Mary, Sport Poster Framed Art
- Overview
When it comes to styling out your space, it's all about formation. Our diagram wall art takes an offensive stance and puts it in the end zone.
- 20" wide x 26" high
- Giclée print is hand framed in wood molding.
- D-ring mounting.
- Dimensions + Care
- Overall: 20" wide x 26" high
- Frame: 1.25" wide
- Wipe with a soft, dry cloth.
- Shipping Info
- Please allow approximately 5-7 business days for delivery of in-stock items. Delivery estimate includes monogrammed and gift-wrapped items.


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By CATHERINE WELCH
PROVIDENCE, RI – Providence Police Chief Dean Esserman has been making headlines since news broke over the weekend that kids with alcohol crashed his daughter's graduation party.
He sat down and talked with WRNI's Catherine Welch about what happened that night.
Do you have insight or expertise on this topic? Please email us, we'd like to hear from you. email@example.com.


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Originally written on The Victory Formation | Last updated 2/27/13
It is year three of the Doug Collins era with the Philadelphia 76ers. That usually spells doom for Collins. The overbearing head coach has never lasted more than three seasons anywhere he has coached. In fact, Collins hasn't coached three full seasons since leading to the Bulls to a Eastern Conference Finals loss to the Pistons in 1988. Granted, the 76ers have had to deal with injury, and the only thing they have seen from Andrew Bynum is his weird hair styles, but this is a team that looks worn down to the bone. They haven't been the most talented team the last few seasons, and have played above their heads thanks to Collins. He is a brilliant basketball coach, but his tough style grates on players. He also isn't one that likes to take blame, such as the case last night when he ranted to the media about his teams lackluster performance against the lowly Magic: Your browser does not support iframes. Here are some of the highlights of it, courtesy CSNPhilly: On his team's lack of effort: "Well I sure didn't see this effort coming. I thought we played incredibly hard against Miami. I thought we played incredibly [...]
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An adhesive composition, primarily intended as a tissue adhesive, comprised of cross-linked proteinaceous material, and methods for its use.
1. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di- or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is human serum albumin.
2. The composition of claim 1 wherein the aldehyde is glutaraldehyde.
3. The composition of claim 1 wherein the concentration of protein is about 40-47 weight %.
4. The composition of claim 1 wherein the concentration of protein is about 35 to 43% by weight.
5. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di- or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is animal serum albumin and the aldehyde is glutaraldehyde.
6. The composition of claim 5 wherein the concentration of protein is about 40-47 weight %.
7. The composition of claim 5 wherein the concentration of protein is about 35 to 43% by weight.
8. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di-or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is bovine serum albumin.
9. The composition of claim 8 wherein the aldehyde is glutaraldehyde.
10. The composition of claim 8 wherein the concentration of protein is about 40-47 weight %.
11. The composition of claim 8 wherein the concentration of protein is about 35 to 43% by weight.
12. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di-or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is concentrated human blood serum.
13. The composition of claim 12 wherein the aldehyde is glutaraldehyde.
14. The composition of claim 12 wherein the concentration of protein is about 40-47 weight %.
15. The composition of claim 12 wherein the concentration of protein is about 35 to 43% by weight.
16. An adhesive composition comprised of a mixture of human or animal-derived protein material in an amount of about 27-53% by weight and a di- or polyaldehyde in an amount of about 1 Part by weight for every 20-60 Parts of protein by weight, balance substantially water, wherein the protein is ovalbumin.
17. The composition of claim 16 wherein the aldehyde is glutaraldehyde.
18. The composition of claim 16 wherein the concentration of protein is about 40-47 weight %.
19. The composition of claim 16 wherein the concentration of protein is about 35 to 43% by weight.
This is a continuation of copending application(s) Ser. No. 07/908,474 filed on Jul. 6, 1992, now abandoned.
1. Field of the Invention
This invention relates to adhesive compositions generally, and more particularly to tissue adhesives useful in the practice of medicine and surgery on human or animal subjects. In general, the adhesive is of high strength, stronger than sutures for example, and creates a non-toxic bond in 30 seconds or less. It works well under wet conditions.
The adhesive compositions are based on cross-linked proteinaceous material of human or animal origin. The compositions provide strong and rapid bonding to a wide range of substrates of natural or synthetic origin, providing a broad range of possible applications. Thus the compositions of present invention bond to living tissues, including muscle, skin, connective tissue, nerve tissue, vascular and cardiac tissues, adipose tissue, cartilage, bone, and the like, as well as to corresponding cadaver tissues, which may be preserved or otherwise chemically treated. Strong bonds are also formed to natural or synthetic materials such as leather, rubber, Dacron, Teflon, and the like, as well as to metals, enabling the use of these compositions for the attachment of surgical grafts and devices, as well as for wound closure, trauma repair, hemostasis, and the like in the practice of human or veterinary medicine. Non medical applications of the adhesive are also anticipated.
In addition to compositions, the invention further relates to the methods of generating the adhesive compositions, and to the methods of achieving bonding or hemostasis through the generation of these compositions in situ.
2. Description of the Related Art
Various types of tissue adhesives are already known in the art. Three of these, namely the cyanoacrylates, gelatin-formaldehyde compositions, and fibrin based glues, have received most attention. For example, fibrin (a blood-clotting protein) and gelatin formaldehyde have each been utilized in surgical adhesive applications as have cyanoacrylates. Such adhesives work to a limited degree but have drawbacks as indicated below.
Several cyanoacrylates have been investigated for surgical use. For instance, some isobutyl cyanoacrylate formulations have been approved for veterinary use. Typically, monomer or a mixture of oligomers and/or monomer is applied to the site to be bonded where it rapidly polymerizes forming an adherent solid. One disadvantage of cyanoacrylate glues is that they require a dry field. Another is that the solid produced is non-absorbable, which limits the usefulness of the glue in internal applications. Also, the polymerization tends to be quite exothermic and adverse tissue response has been reported. There are a number of citations relating to this type of prior art indicated in the references listed at the end of this specification.
Glues based on gelatins cross linked with formaldehyde have been used experimentally, principally in Europe, since about 1964. Several formulations have been proposed of which "GRF" (gelatin, resorcinol, formol) is best known. Hot solutions of select gelatin are mixed in situ with a curing agent consisting primarily of formaldehyde solution. The mixture rapidly sets to a solid which adheres to tissues. The chief objection to GRF glues has been the obligatory use of formaldehyde, a known hazardous material. Also, the gelatin must be applied hot, significantly above body temperature, and the techniques of mixing and application are quite critical for successful use of GRF. Pertinent references relating to GRF glues are listed in the References section.
Fibrin Glues utilize the natural processes of blood clot formation to generate an adhesive or sealant composition. One commercial product is "Tussicol"�, Rugis, France. Another is "Fibrin Sealant Kit 1.0" available from Osterreiehisehes Institut fur Ilaemoderivate, GMBH, subsidiary of Immuno AG, A-1220, Vienna, Austria. Two components are combined to form an artificial blood clot. One of the components is a solution of fibrinogen and blood clotting factors such as Factor XlII, and the other is primarily a solution of thrombin and calcium ion. Disadvantages of fibrin glues include their very low strength (generally less than 50 g./sq. cm.) and relatively slow set up time. Also, the use of blood products (fibrinogen and co-factors) from multiple human donors presents an inherent risk of transmitting certain diseases to the patient. Procedures have been proposed for using autologous blood to prepare fibrin sealant. See for instance Reference 20 in the References section.
As a surgical adhesive, the compositions of the invention have a bonding strength that is many times stronger than conventional fibrin adhesives and traditional sutures. For instance, several experimental surgical procedures were successfully carried out (in a porcine model) using the adhesive composition. For example, a perforated aorta and bowel were repaired by gluing patch materials to the lesions, and hemostasis was quickly achieved in a resected spleen by application of the adhesive.
The adhesive compositions of the present invention are the products of cross-linking on a surface or surfaces to be bonded of a mixture initially containing:
Part A.- a water soluble proteinaceous material of about 27-53% by weight of the mixture.
Part B.- di- or polyaldehydes present in a weight ratio of one part by weight to every 20-60 parts of protein present by weight in the mixture and water, optionally containing non essential ingredients to make up the balance of the composition. The final cross-linked bonding compositions are water insoluble, rubbery or leathery proteinaceous solids substantially free of aldehydes, and adherent to the substrate to be bonded with a tear strength of at least 75 g./sq. cm.
Bonding is achieved by combining the two part system (the parts being referred herein as Part A and B, respectively), and allowing the mixture to react on the surface or surfaces to be bonded. Bond formation is rapid, generally requiting less than one minute to complete. The resulting adhesion is strong, generally providing bonds with tear strengths of 400-600 g./sq.cm. Tear strengths of 1300 g./sq.cm. have been obtained by using this invention. The upper limits of tear strength have not been determined, and they are not intended to be interpreted as limiting the invention.
Part A is an aqueous solution containing about 30-55% by weight of purified or mixed protein material. The balance is water, dilute buffer, and/or saline solution, optionally containing non-essential materials which do not significantly interfere with the adhesive forming reaction. Examples of such non-essential materials are neutral salts, carbohydrates, fibers and miscellaneous biological materials, wetting agents, antibiotics, preservatives, dyes, thickening agents, and the like. For example, nonessentials such as fibrinogen or poly(ethylene glycol) as shown in Examples 5 and 19 and in 9 respectively, hereof may be included.
Part B is a solution of a di- or polyaldehyde in water or other suitable medium. Glutaraldehyde in 5-15% solution is preferred, but other aldehyde materials are also suitable. Thus, aqueous glyoxal is satisfactory for Part B, as are aqueous mixtures of di- and polyaldehydes obtained by oxidative cleavage of carbohydrates and their derivatives with periodate, ozone, or the like. Other water soluble di- and/or polyaldehydes will be readily recognized as useful for the purpose of this invention.
When a mixture of Parts A and B is allowed to react on a surface or surfaces to be bonded, an adherent composition forms, generally in less than one minute, even 30 seconds or less. A wide range of substrates can be bonded by this process, as previously indicated. No significant exotherm is observed, and good adhesion is obtained to wet surfaces, thus providing a wide range of usefulness for the invention.
As previously stated, it is the composition of the mixture of Parts A and B prior to cure, and most particularly its protein content by weight, which describes the limits of useful bonding compositions. The manner in which the bonding composition is assembled in practice (prior to cure) is not a limiting factor, and may vary with the intended use. Preferred ranges of concentrations for Parts A and B which on mixing produce the bonding composition will be discussed below as well as in the Examples.
As already indicated, Part A of the adhesive composition is substantially an aqueous solution of a proteinaceous material of human or animal origin. Albumins including ovalbumins are preferred proteins, and serum albumins of human or animal origin are particularly preferred. The proteinaceous material may be a purified protein or a mixture in which the proteins such as serum albumins are the predominant ingredients. For example, the solid mixtures obtained by dehydration of blood plasma or serum, or of commercial solutions of stabilized plasma proteins, can be used to prepare Part A. These mixtures, generally referred to as plasma solids or serum solids, are known to contain albumins as their major ingredients, of the order of 50-90%. As used herein, the term "plasma" refers to whole blood from which the corpuscles have been removed by centrifugation. The term "serum" refers to plasma which has additionally been treated to prevent agglutination by removal of its fibrinogen and/or fibrin, or by inhibiting the fibrin clot formation through addition of reagents such as citrate or EDTA.
Part B of the adhesive composition is substantially an aqueous solution of di- or polyaldehydes. A wide range of these substances exist, and their usefulness is restricted largely by availability and by their solubility in water. For example, aqueous glyoxal (ethandial) is useful, as is aqueous glutaraldehyde (pentandial). Water soluble mixtures of di- and polyaldehydes prepared by oxidative cleavage of appropriate carbohydrates with periodate, ozone, or the like are also useful. Glutaraldehyde is the preferred dialdehyde ingredient of Part B.
When Parts A and B are brought together as described in the Examples hereinbelow, the resultant product rapidly hardens to a strong leathery or rubbery material within a short time of mixing, generally on the order of 15-30 seconds. Strong adhesion results if the adhesive composition is on one or both surfaces to be bonded and the surfaces are brought together before the bond hardens. Full bond strength is generally attained in less than a minute but those familiar with this art will recognize that manipulating variables such as the particular ingredients used as Parts A and B, temperature, and so forth will affect the rate of bond formation. For instance, markedly reduced cure rates are observed when di- or polyaldehydes derived by oxidative cleavage of carbohydrates are used as Part B. Likewise, when Part A is based on plasma solids, full bond strength is generally obtained about twice as fast as when purified bovine serum albumin is used.
As indicated previously, effective bonding results whenever the composite mixture of Parts A and B falls within the acceptable range specified above, that is, 27-53% by weight of protein, as well as the prerequisite amounts of dialdehyde and water, However, if said mixture is to be produced by mechanically mixing Parts A and B on the surface(s) to be bonded, there are some preferred ranges of concentration within which Parts A and B should fall to facilitate said mixing. Thus, it is preferred to utilize protein solutions (Part A) with a solids content of about 30-50% by weight, and to mix these with dialdehyde solutions (Part B) of 5-15% by weight.
When generating the adhesive compositions of this invention, the Parts A and B can be pre-mixed and applied to the surface(s) to be bonded immediately following mixing by means of a syringe, catheter or other device. Alternately, the Parts A and B can be applied simultaneously, as for example from a dual nozzle device and mixed on the surface(s) to be bonded. Sequential application of Parts A and B to the surfaces is also satisfactory with the sequence B, then A, then B preferred.
In practice it is most convenient to mix Part A (containing 40-47% proteins in solution A, the balance being water and non-essentials) with Part B (containing 5-15% of glutaraldehyde or other di- or polyaldehyde, the balance again being water and/or non-essentials). However, in some applications it may be preferable to deviate from the above concentrations of A and B, provided, however, that the composition of the resulting mixture remains within the limits specified earlier. It is also convenient in some applications to utilize a slight excess of B, since unreacted material is readily neutralized after the bond is formed. Dilute solutions of proteins, peptides, or amino acids applied at about 5% concentration are suitable for that purpose.
Most preferably, Part A is pasty and Part B is liquid. When combined a honey-like composition (looks and consistency) is obtained.
Part A may be prepared by dissolving in water the dry proteinaceous solids, optionally containing non essential materials, or the protein solids may be dissolved in water which may optionally contain said non-essentials. The dry proteinaceous solids may be prepared by lyophilization of dilute proteinaceous solutions such as plasma or serum, or of commercial plasma extenders such as Plasma-Plex� or Plasmanate�, which are stabilized, reconstituted solutions of plasma proteins containing about 5% protein by weight, or of other appropriate solutions. Purified protein powders such as human or animal serum albumins, ovalbumin, or mixtures of protein powders may also serve to prepare Part A.
Plasma-Plex� (Plasma-Plex Plasma protein fraction (human) USP 5% solution, heat treated, Armour Pharmaceutical Company, Kankakee, Ill., 60901) and Plasmanate� (Plasma protein fraction (human) USP 5% solution Miles, Inc. Cutter Biological, Elkhart, Ind., 46515, USA, Miles Canada, Inc., Etobiocoke, Ontario Canada) were used as described above.
An alternative route to the preparation of Part A is the concentration of dilute proteinaceous solutions to the required solids content. This approach is particularly useful for the preparation of adhesive from a patient's own blood or from screened blood obtained from a single donor. Many techniques are available for concentrating protein solutions and they are well known by those skilled in the art. Among them may be listed lyophilization and reconstitution (mentioned above), evaporation, contact with hygroscopic solids, dialysis, ultrafiltration, and vacuum centrifugal evaporation. Other methods of concentrating dilute solutions may be preferable in particular applications.
The proteinaceous ingredient of Part A may be a purified protein or a mixture of proteins. Albumins are generally preferred, and serum albumins of human or animal origin are particularly useful. For example, the gross mixture of materials obtained by lyophilizing plasma or serum and containing about 90% by weight of serum albumin is satisfactory for preparing Part A, as are purified human or bovine serum albumins. A mixture of bovine serum albumin (ca. 95 parts) and bovine fibrinogen (ca. 5 parts) is particularly useful, and results in very strong bonds, typically 800-1200 g/sq. cm. The solid mixture obtained by lyophilizing egg whites and consisting largely of ovalbumin, is also satisfactory for preparing Part A. Other sources of proteinaceous material will be apparent to practitioners of the art.
Preferred embodiments of the invention are further illustrated by the following Examples:
Dry plasma solids were obtained by lyophilizing fresh frozen human plasma. Water was added to this solid to produce a viscous solution containing 45% of solids by weight. This solutions was used as Part A. Part B was aqueous glutaraldehyde solution containing 10% of glutaraldehyde by weight. Two rectangular blocks of meat were sprayed lightly with B on the surfaces to be bonded. The surfaces were then coated with A to a thickness of 1-2 mm, and again sprayed with B. The ratio of A to B was 7 to 1 by weight. The surfaces were joined within about 10 seconds of the application of A and held in position until cure was complete, generally 15-60 seconds, depending on temperature and on the effectiveness of mixing A and B.
To determine tear strength the glued rectangular block of meat was attached with clamps to a spring balance at one end and to a variable weight on the other. The weight was increased progressively until the bond or adjoining meat broke. Tear strength was recorded in g./sq.cm. required to break the bond. Tear strengths were determined one minute after joining the surfaces, unless otherwise noted. Typical tear strengths for the above composition were 445 g./sq. cm.
When the sequence of application of A and B is reversed or when A and B are applied simultaneously or when A and B are pre-mixed immediately prior to application, essentially the same bond strengths are observed.
Same as Example 1, except that a heat treated 5% plasma protein fraction (human) USP was used to produce the dry solids, and its concentration within Part A was 47% by weight. Adhesion was achieved as described above. Tear strengths ranged from 550-624 g./sq. cm.
Bovine serum albumin was dissolved in water to produce a solution containing 40% by weight solids, which was then used as Part A as described in Example 1 to bond meat blocks. Tear strengths ranged from 514-629 b./sq. cm.
Human serum albumin solutions containing 40-45% by weight of protein were prepared by concentrating 25% solutions by means of dialysis. When these solutions were used as Part A in bonding as described above, the tear strengths ranged from 605-922 g./sq. cm.
When Part A was a solution with a solids content of 45.5% by weight and consisting of a mixture of bovine serum albumin and bovine fibrinogen in which the albumin constituted 90-97%, the resulting bond tear strengths ranged from 786 to over 1280 g./sq. cm.
Synthetic vascular prostheses made of Dacron and prostheses made of Teflon, as well as cadaver derived human vascular graft materials were successfully bonded to meat or to each other using any of the compositions described in all of the Examples included herein. For instance, the tear strength obtained with the composition of Example 5 for the bond between beef and woven Dacron vascular prosthesis was above 890 g./sq.cm. measured in shear mode while that to a Teflon graft was 670 g./sq.cm. Similarly, implantable medical electrodes coated with silicone rubber showed a tear strength of 1080 g./sq.cm. utilizing bovine serum albumin in Part A.
Part A, containing 30-32% by weight of human serum albumin was prepared from either fresh plasma or from stabilized 5% plasma protein solutions by ultrafiltration (both were done). When 50% aqueous glutaraldehyde was used as component B the tear strengths of the resulting bonds ranged between 267-335 g./sq.cm.
Part A was 30% by weight of human plasma protein prepared from 5% stabilized solution (USP) as described in Example 7 above. Part B was 25% by weight aqueous glutaraldehyde. Parts A and B were mixed in a weight ratio of 10 Parts A to 1 Part of B resulting in a mixture containing 27% proteins by weight. This mixture was immediately applied to the surfaces of two meat blocks and the blocks were joined. The resulting bond had a tear strength of 75 g./sq/cm/
When meat blocks were joined as described in Example 1, but using 47% aqueous bovine serum albumin as A and 10% aqueous glyoxal as B the tear strength was 333 g./sq.cm.
A specimen containing a high proportion of skin and adipose tissue was joined using as Part A an aqueous solution containing about 41% bovine serum albumin and 4% poly(thylene glycol) of 15-20000 molecular weight, and 10% glutaraldehyde as Part B. The tear strength of the bond produced was 1300 g./sq. cm.
The adhesive composition described in Example 1 was successfully used in several surgical procedures on a 35-40 lb. pig. The procedures carried out were applications of patches (without sutures) to perforated abdominal aorta and bowel, and hemostasis of resected spleen. The patches were cut from human cadaver pulmonary artery tissue processed for use as a graft material in human cardiovascular surgery.
Part A was 47% bovine serum albumin. Part B was prepared as follows: methyl glucoside (0.5 g.) was dissolved in water (4.1 mL) and oxidized with sodium periodate (1.0 g.) in the presence of sodium bicarbonate in an ice bath during 45 min. The products of this reaction are known to be a complex dialdehyde in about 10% concentration by weight, as well as non essential salts. This solution was used as Part B without purification. The mixture cured to a flexible bond in about one hour with a tear strength of 320 g./sq.cm.
Same as
As in Example 11, but using sucrose (0.5 g.), sodium periodate (1.0 g.), sodium bicarbonate (1.0 g.) and water (5.0 mL). The resulting product solution is known to contain a mixture of complete di-, tetra- and polyaldehydes in about 8%. Resulting bond strength was 364 g./sq. cm.
The solid mixture obtained by lyophilizing egg white, and consisting predominantly of ovalbumin, was dissolved in water to make solutions with a solids content ranging from 40-44.8%. When these solutions were used as Part A in adhesion studies using 10% aqueous glutaraldehyde as Part B, the tear strengths obtained ranged form 255-339 g./sq. cm.
Bovine serum albumin (BSA) was dissolved in water in the concentrations shown and used as Part A. Part B was 10% aqueous glutaraldehyde. The following tear strengths were measured:
______________________________________Weight % BSA Tear Strength (gm/cm2)______________________________________25 <5030 <5035 10040 514-62945 61050 96-557*______________________________________ *Too viscous to spread evenly.
Plasma-Plex�, a 5% solution of human protein fraction (USP) was lyophilized, the resulting solids constituted with water to the concentrations shown below, and the solutions used as Part A. Part B was 10% aqueous glutaraldehyde. The following tear strengths were observed:
______________________________________Weight % HSA Tear Strength (gm/cm2)______________________________________35 <5037 163-25741 250-38143 358-41345 .sup. 423-567+47 550-62451 .sup. 400-527+53 338-50055 85-390*______________________________________ + Indicates that the substrate tissue tore rather than the bond. *Too viscous to apply evenly.
As in Example 17, but using solids obtained by lyophilizing fresh frozen plasma gave the following tear strengths:
______________________________________Weight % HSA Tear Strength (gm/cm2)______________________________________30 136-26935 486.sup.40 550+45 .sup. 444-445+50 278-36155 150-226*60Not soluble-______________________________________ + Indicates substrate tissue tore rather than the bond. *Too viscous to spread well.
Mixtures of proteins can be used in the concentration ranges of the invention for Part A. For example, bovine serum albumin (BSA) and bovine fibrinogen (BF) produce an excellent adhesive: Total solids (mixed) 45.5 weight percent.
______________________________________PERCENT BSA PERCENT BF Tear Strength (gm/cm2)______________________________________97 3 .sup. 708-1280+93.3 6.7 .sup. 797+90 10 78680 20 736-237*______________________________________ + Indicates substrate tissue tore rather than the bond. *BF not fully soluble, solution is rubbery.
Mixtures such as these i.e., 93 parts BSA to 7 parts BF@45-46% solids particularly bonded aggressively to Dacron and PTFE at strengths of 890+ to 1200+.
Generally, good bonding is achieved either by applying A or B first or simultaneously e.g., from a dual nozzle. Also, methods of mixing in situ provide good bonds. Parts A and B may be applied in sequence, B then A, then B; or A, then B; or simultaneously with mixing on the surface(s) to be bonded; or through a catheter or catheters; or via syringe or similar device immediately following pre-mixing.
1. Dresdale, Arthur, M.D., Rose, Erie A., M.D., Jeevanandam,
Valluvan, M.D., Reemtama, Keigh, M.D., Bowman, Frederick O., M.D., and Maim, James R., M.D.: "Preparation of Fibrin
Glue From Single-Donor Fresh-Frozen Plasma." Surgery Vol. 97, No. 6 (1985).
2. Sindou, Marc, M.D., D. Sc. Biol., Gilg, Alain, M.D., Vighetto, Alain, M.D., and Jouvet, Anne, M.D.: "Cryptic Angioma in the Trochlear Nerve. Excision of the Invaded Portion and Successful Repair with an Autologous Graft: Case Report." Neurosurgery Vol. 30, No. 2 (1992).
3. Dubrow, Terry, M.D., Schwartz, Robert J., M.D., McKissock, John M.D., Wilson, Samuel E., M.D.: "Effect of Aerosolized Fibrin Solution on Intraperitoneal Contamination. Arch. Surg. Vol. 126, (January 1991).
4. Mandel, Mark A., M.D.: "Closure of Blepharoplasty Incisions With Autologous Fibrin Glue". Arch Opthalmol Vol. 108, (June 1990).
5. Lyons, Michael B., M.D., Lyons, George D., M.D., Webster, Douglas, PhD, Wheeler, Valerie R., M.D.: "Adhesives in Larynx Repair". Laryngoscope Vol. 99 (April 1989).
6. Laitakari, Kyosti, M.D., Luotonen, Jukka, M.D.: "Autologous and Homologous Fibrinogen Sealants: Adhesive Strength." Laryngoscope Vol. 99 (September 1989).
7. Bachet, J., M.D., Goudot, B., M.D., Teodori, G., M.D., Brodaty, D., M.D., Dubois, C., M.D., De Lentdecker, Ph., M.D., Guilmet, D., M.D.: "Surgery of type A acute aortic dissection with Gelatine-Resorcine-Formol biological glue: A twelve-year experience." J. Cardiovasc. Surg. Vol. 31 (1990).
8. Fabiani, Jean-Noel, M.D., Gebara, Victor A., M.D., DeLoche, Alain, M.D., Carpentier, Alain, M.D. PhD.: "Use of Glue Without Graft Replacement for Type A Dissections: A New Surgical Technique." Ann. Thorac. Surg. 143-5 (1990).
9. Fabiani, Jean-Noel, M.D., Jebara, Victor A., M.D., Deloche, Alain, M.D., Stephan, Yves, M.D., Carpentier, Alain, M.D., PhD.: "Use of Surgical Glue Without Replacement in the Treatment of Type A Aortic Dissection." Supplement I Circulation Vol. 80, No. 3 (September 1989).
10. Bachet, J., M.D., Gigou, F., M.D., Laurian, C., M.D., Bical, O., M.D., Goudot, B., M.D., Guilmet, D., M.D.: "Four-year clinical experience with the gelatin-resorcine-formol biological glue in acute aortic dissection." J. Thorac. Cardiovasc. Surg. Vol. 83 (1982).
11. Braunwald, Nina S., M.D., Gay, William, M.D., Tatooles, Constantine J., M.D.: "Evaluation of crosslinked gelatin as a tissue adhesive and hemostatic agent: An experimental study." Surgery Vol. 59, No. 6 (June 1966).
12. Marescaux, J. F., Aparahamian, M., Mutter, D., Loza, E., Wilhelm, M., Sonzini, P., Damge, C.: "Prevention of anastomosis leakage: an artificial connective tissue." Br. J. Surg. Vol. 78, No. 4 (April 1991).
13. Celik, H., Caner, H., Tahta, K., Ozcan, O. E., Erbenti, A., Onol, B.: "Nonsuture closure of arterial defect by vein graft using isobutyl-2-cyanoacrylate as a tissue adhesive." Journal of Neurosurgical Sciences Vol. 35, No. 2 (April-June 1991).
14. Aprahamian, Marc, Lambert, Alain, Balboni, Ginette, Lefebvre, Francoise, Schmitthaeusler, Roland, Damge, Cristiane, Rabaud, Michel: "A new reconstituted connective tissue matrix: Preparation, biochemical, structural and mechanical studies." Journal of biomedical Materials Research Vol. 21 (1987).
15. Meyer, G., Muster, D., Schmitt, D., Jung, P., Jaeger, J. H.: "Bone Bonding Through Bioadhesives: Present Status." Biomat., Med. Der., Art. Org. 7(1) (1979).
16. Nina S. Braunwald, William Gray, and Constantine J. Tatooles, Surgery. June 1966, 1024-1030. Relates to GRF glue.
17. J. Bachet et al., L Thorac, Cardiovasc. Surg. 83: 212-217 (1982). Relates to GRF glue.
18. J-N. Fabiani et al., Ann. Thorac. Surg. 50:143-145 (1990). Relates to GRF glue.
19. J. Bachet et al., J. Cardiovasc. Surg. 31:263-273 (1990). Relates to GRF glue.
20. Arch. Opthalmol. 108: 842-844, (1990).
1. "Tissue glues and the fibrin glue system [Cze]." Rozhledy V Chirugii 70(5) (March 1991).
2. Cartwright, R A., McKinney, P A., O'Brien, C., Richards, I D., Roberts, B., Lauder, I., Darwin, C M., Bernard, S M., Bird, CC.: "Non-Hodgkin's Lymphoma: Case Control Epidemiological Study in Yorkshire Institution." Abstract From the Department of Pathology, University of Leeds, U.K. Journal Lukemia Research 12(1):81-8, (1988).
3. Harris, David M., PhD., Siedentop, Karl H., M.D., Sanchez, Ben, M.D.: "Autologous Fibrin Tissue Adhesive: Factors Influencing Bonding Power". Abstract from Laryngoscope Vol. 98 (July 1988).
4. Havlicek, K., Vlcek, B., Stastny, 1.: "Hemostatic and adhesive properties of fibrin tissue glue in an experiment." Rozhledy V Chirugii 70(5) (March 1991).
5. Havlicek, K., Vlcek, B., Stastny, 1.: "Fibrin tissue glue, its preparation and methods of application." Rozhledy V Chirugii 70(5) (March 1991).
6. Byrne, D. J., Hardy, J., Wood, R. A., Mcintosh, R., Cuschiefi, A.: "Effect of fibrin glues on the mechanical properties of healing wounds." British Journal of Surgery 78(7) (July 1991).
7. Rudigoz, R. C., Chabert, P.: "Use of fibrin glue in gynecology-obstetrics [Fre]." Revue Francaisc De Gynecologie Et D Obstetrique 85(10) (October 1990).
8. Beltramello, A., Benati, A., Perini, S., Maschio, A.: "Interventional angiography in neuropediatfics." Childs Nervous System 5(2) (April 1989).
9. Laitakari, K., Luotonen, J.: "Autologous and homologous fibrinogen sealants: adhesive strength." Laryngoscope 99(9) (September 1989).
10. Herter, T.: "Is there a preference among fibrin glues for nerve anastomosis? [Ger]." Hno. 37(6) (June 1989).
11. Gigauri, V. S., Movchun, A. A., Got'e, S. V., Sheremet'eva, G. F., Shidkov, I. L.: "Use of fibrin glue in surgery of parenchymatous organs [Rus]." Khirurgiia (4) (April 1989).
12. Sackett, D. L.: "Simple and inexpensive preparation of dried polyacrylamide gels for densitometry and/or storage." Analytical Biochemistry 179(2) (June 1989).
13. "Dura mater healing after repair with aponeurotic plasty. Comparison of results between classical sutures and fibrin adhesive glue. Fibrin adhesive in frontobasal injuries. An experimental study [Frei." Neuro-Chirurgie 34(5) (1988).
14. Beloglazova, S. E.: "Cyanoacrylate glues and their use in gynecology [Rus]. Akusherstvo I Ginekologiia-Moskva (5) (May 1988).
15. Feldman, M. D., Sataloft, R. T., Ballas, S. K.: "Autologous fibrin tissue adhesive for cerebrospinal fluid leaks: A controlled study of neurotoxicity." American Journal of Otology. 9�4) (July 1988).
16. Jebara, V. A., Fabiani, J. N., Couetil, J. P., Acar, C., Dreyfus, G., Delouche, A., Carpentier, A.: "Exclusive use of surgical glue without graft replacement for type A aortic dissection: A new technique." European Heart Journal (1989)
17. Brothers, M. F., Kaurmann, J. C., Fox, A. J., Deveikis, J. P.: "n-Butyl 2-cyanoacrylate-substitute for IBCA in interventional neuroradiology: histopathologic and polymerization time studies." Ajnr--American Journal of Neuroradiology 10(4) (July-August 1989).
1. Rose, Eric, Dresdale, Arthur: "Fibrin Adhesive Prepared as a Concentrate from Single Donor Fresh Frozen Plasma." U.S. Pat. No. 4,627,879, Issued Dec. 9, 1986.
2. Takehisa Matsuda, Minoo, Hiree Iwata, Suita, Tetsuro Itoh, Shiga: "Surgical Adhesive." U.S. Pat. No. 4,740,534, Issued Apr. 26, 1988.
3. Ritter, Wolfgang: "Surgical Adhesive Systems for Hard Body
Tissues." U.S. Pat. No. 4, 626,310, Issued Dec. 2, 1986.
4. Robinson, Joseph R.: "Bioadhesive Compositions and Methods of Treatment Therewith." U.S. Pat. No. 4,983,392, Issued Jan. 8, 1991.
5. Rose, Eric, Dresdale, Arthur: "Fibrin Adhesive Prepared as a Concentrate From a Single Donor Fresh Frozen Plasma." U.S. Pat. No. 4,627,879, Issued Dec. 9, 1986.
6. Iwatsuki, Makoto, Hayashi, Toshio: "Silk-Fibroin and Humane Fibrinogen Adhesive Composition." U.S. Pat. No. 4,818,291, Issued Apr. 4, 1989.
7. Reimann, Albert: "Method of Processing Blood." U.S. Pat. No. 2,241,868, Issued May 13, 1941.
8. Bering, Edgar A., Jr.: "Fibrin Foam." U.S. Pat. No. 2,492,458, Issued Dec. 27, 1949.
9. Cornwell, Earl D., Dobija, Stephen: "Method of Treating Proteins With Saturated Aliphatic Polyamines and Resulting Product." U.S. Pat. No. 2,597,228, Issued May 20, 1952.
10. Schwarz, Otto, Linnau, Yendra, Loblich, Franz, Seelich, Thomas: "Tissue Adhesive." U.S. Pat. No. 4,362,567, Issued Dec. 7, 1982.
11. Schwarz, Otto, Linnau, Yendra, Loblich, Franz, Seelich, Thomas: "Tissue Adhesive." U.S. Pat. No. 4,414,976, Issued Nov. 15, 1983.
12. Stroetmann, Michael: "Enriched Plasma Derivative for Advancement of Wound Closure and Healing." U.S. Pat. No. 4,427,650, Issued Jan. 24, 1984.
13. Stroetmann, Michael: "Enriched Plasma Derivative for Enhancement of Wound Closure and Coverage." U.S. Pat. No. 4,427,651, Jan. 24, 1984.
14. Fuhge, Peter, Heimburger, Norbert, Stohr, Hans-Arnold, Burk, Wolfgang: "Readily Dissolvable Lyophilized Fibrinogen Formulation." U.S. Pat. No. 4,650,678, Issued Mar. 17, 1987. 15. Dixon, France T.: "Crosslinked Anisotropic Mammalian Diaphragm in Surgical Reconstruction." U.S. Pat. No. 4,813,958, Issued Mar. 21, 1989.
16. Seelich, Thomas: "Method of Inactivating Reproductive Filterable Pathogens in Fibrinogen and Factor XIII Compositions." U.S. Pat. No. 4,816,251, Issued Mar. 18, 1989.
17. Kotitschke, Ronald, Stemberger, Axel W., Stephan, Wolfgang: "Method of Preparing a Sterile Plasma-Protein Solution Containing Fibrinogen and Factor XIII." U.S. Pat. No. 5,099,003, Issued Mar. 24, 1992.
18. Grauert, Hugo: "Defibrillated Blood or Blood Serum Formula." German Pat. No. 251,126, Issued Sep. 17, 1912.
19. Kumpe, Grhardt, Wormsbacher, Wilfried, Heimburger, Norbert, Fuhge, Peter, Preis, Hans-Martin: "Human Fibrinogen Aq. Solns. Pasteurisation--in Presence of Added Calcium as well as
Usual Stabilizers." German Pat. No. 32 30 849 Al, Issued Feb. 1989.
20. "Frozen Fibrinogen Prepn.--by Dissolving Dry Fibrinogen in Low Salt Content Buffer Soln., Contg. Mono:Saccharide, and Freezing Soln. Obtd." Japanese Pat. No. 57149-229, Issued Sep. 1982.
21. "Production of Sponge For Local Haemostasis--Includes Coagulation of Blood Plasma Pretreated With Amino-Benzoic Acid Using Calcium Chloride Soln." Soviet Union Pat. No. 741-878, Issued Jun. 1980.
While this invention may be embodied in many different forms, there are described in detail herein specific preferred embodiments of the invention. The present disclosure is an exemplification of the principles of the invention and is not intended to limit the invention to the particular embodiments illustrated.
This completes the description of the preferred and alternate embodiments of the invention. Those skilled in the art may recognize other equivalents to the specific embodiment described herein which equivalents are intended to be encompassed by the claims attached hereto.
Patent Citations
Non-Patent Citations
Referenced by
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ibis Lagos Airport is a smoke-free property. Dining facilities at the hotel include a restaurant. A rich, complimentary breakfast is served each morning. The hotel boasts a 24-hour front desk service. A currency exchange facility is also available. Public areas at ibis Lagos Airport are comfortably air-conditioned. Hotel guests will appreciate the welcoming services of our multilingual staff. Other hotel amenities include garden and tennis court(s). Leisure amenities: There is an outdoor swimming pool at the hotel. Other services: elevator/lift, express check-out, laundry facilities, medical assistance available and television in lobby. Business/Internet: ibis Lagos Airport features a well-equipped business centre. The following Internet options are available at the hotel: high-speed wired access, high-speed wireless access are complimentary.
Transportation/Parking facilities
Guests can also use area shuttle (fee applied). For guest convenience, parking is offered at no extra cost in a garage. Valet parking is also available.
Hotel Services and Facilities
DiningEnjoy a satisfying meal at a restaurant serving guests of Ibis Lagos Airport. Quench your thirst with your favorite drink at a bar/lounge.
Hotel facilities
- Restaurant
- Fitness facilities
- Free wired high-speed Internet
- Breakfast available (surcharge)
- Safe-deposit box at front desk
- Area shuttle (surcharge)
- Bar/lounge
- Airport transportation (surcharge)
- 24-hour front desk
- 24-hour business center
- Express check-in
- Conference center
- Luggage storage
- Garden
- Television in lobby
- Free self parking
- Elevator/lift
- Pool umbrellas
- Express check-out
- Designated smoking areas
- Laundry facilities
- Computer station
- Multilingual staff
- Conference space
- Free WiFi
- Outdoor pool
Important information
- No pets and no service animals are allowed at this property.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
How to bookMaking your reservation in Ibis Lagos Airport is easy and secure. Simply select your dates of stay and click on the "Check Rates" button to submit the form.
After room types and rates are returned to your screen, you will be able to choose the rate you desire by reading the room information in the center of the screen, then clicking on the "Book Now" button on the right side of the screen. After you have selected your desired room type, you will be taken to a "Complete your booking" form. Then you will need to review the "Details of your stay" and fill in the blanks on the "Guest Details" section. Be sure your name and email address are spelled correctly.
After you fill out all of the needed information, press the "Complete reservation" button. To ensure your security, we use a secure commerce server, which encrypts the credit card number and encodes it into a non-usable form.
Area informationDistances are calculated in a straight line from the property's location to the point of interest or attraction, and may not reflect actual travel distance.
Distances are displayed to the nearest 0.1 mile and kilometer.
Ikeja Golf Club - 3.9 km / 2.4 mi
Computer Village - 5.2 km / 3.3 mi
Teslim Balogun Stadium - 6.5 km / 4 mi
Synagogue Church Of all Nations - 6.6 km / 4.1 mi
University of Lagos - 7 km / 4.4 mi
Actis Ikeja Mall - 7.6 km / 4.7 mi
Lagos State Government Secretariat - 7.7 km / 4.8 mi
First Baptist Church Abule Egba - 12.1 km / 7.5 mi
Ezekiel International College - 13 km / 8.1 mi
Lagos City Mall - 14.1 km / 8.8 mi
Nigerian National Museum - 14.1 km / 8.8 mi
MUSON Centre - 14.1 km / 8.8 mi
Lagos Motor Boat Club - 14.6 km / 9.1 mi
Ikoyi Golf Club - 15.6 km / 9.7 mi
Silverbird Galleria - 16 km / 9.9 mi
The preferred airport for Ibis Lagos Airport is Lagos (LOS-Murtala Muhammed Intl.) - 2.4 km / 1.5 mi.


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Originally written on Fox Sports West | Last updated 9/7/12
EL SEGUNDO The Los Angeles Lakers have hired Eddie Jordan, Steve Clifford and Bernie Bickerstaff as assistant coaches, it was announced today by Lakers General Manager Mitch Kupchak. Jordan, a former NBA player (1977-84) and member of the Lakers 1982 Championship team, most recently spent one season (2009-10) as head coach of the Philadelphia 76ers. Prior to his time in Philadelphia, Jordan, a native of Washington D.C. served as head coach of the Wizards. During his six years (2003- 2009) in Washington, Jordan posted a 197-224 record and in just his second season at the helm, guided the Wizards to their highest win total (45) in 25 years and the teams first postseason appearance since 1996-97. Prior to joining the Wizards, Jordan served as the lead assistant coach for the New Jersey Nets. During his four-year stint with the Nets, the team made the Finals in back-to-back years (2002 and 2003). Additionally, Jordan spent seven years with the Sacramento Kings both as an assistant coa...
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Press release from Business Wire
Procter & Gamble Nearly Doubles Money Raised for the USOC's P&G | Team USA Youth Sports Fund through 'Thank you, Mom' Campaign; Announces $25 Million Global Program
Thursday, August 09, 2012
Procter & Gamble Nearly Doubles Money Raised for the USOC's P&G | Team USA Youth Sports Fund through 'Thank you, Mom' Campaign; Announces $25 Million Global Program11:28 EDT Thursday, August 09, 2012 LONDON (Business Wire) -- Procter & Gamble (NYSE:PG), a Worldwide Olympic Partner, today announced that due to strong consumer response it has nearly doubled the amount of money the company hoped to contribute to the United States Olympic Committee's (USOC) P&G | Team USA Youth Sports Fund. P&G launched the fund in April with the goal of raising $500,000 through the London 2012 Olympic Games. The company today also announced plans to raise $25 million globally for youth sports, as part of its 10-year partnership with the International Olympic Committee (IOC). Earlier this year, P&G announced a plan to raise $5 million to support youth sports globally by the end of the London 2012 Olympic Games. This pledge has already been exceeded, with more than $6 million now donated for sports development, school equipment, youth funds and scholarships and places in summer sports camps across the world. The USOC's P&G | Team USA Youth Sports Fund is part of P&G's 'Thank you, Mom' campaign and helps moms raise happy, healthy kids by providing broader access to youth sports programs in the United States. Strong consumer engagement in the 'Thank you, Mom' campaign has allowed the company to double its original U.S. goal and raise nearly $1 million to provide even more kids greater access to sports. Funds are raised by sales and donations from the Company's leadership brands including Pampers®, Tide®, Gillette® and Pantene®. "Consumer engagement in our 'Thank you, Mom' campaign has far exceeded our own projections," said Jodi Allen, Vice President of North American Operations and Marketing at P&G and herself a mom of four. "Using our voice at the Olympic Games to celebrate moms for everything they do to raise great kids, whether they make it to the Olympic Games stage or not, is something that every mom and family understands and appreciates." Kerri Walsh, who just yesterday collected her third gold medal in beach volleyball, is both a mom and athlete sponsored by P&G and its Pampers brand. "Sports have played a rich and meaningful role in my life since early childhood and, as a mother, I value the role they play in helping my children have healthy, well-rounded lives. Supporting today's little athletes, whether or not they grow up to become tomorrow's Olympians, is essential. Play helps babies develop, just as sports help children learn important life skills and I'm delighted to help P&G and Pampers in their announcement today," she said. The P&G | Team USA Youth Sports Fund benefits USOC youth sport organizations across the country and donations are executed through the National Governing Bodies (NGBs) to support their programs for the Olympic and Paralympic Games. Several NGBs will receive grants including Archery, Blind Athletes, Field Hockey, Gymnastics, Swimming, Volleyball (beach and sitting), Water Polo and Wrestling, which will impact millions of kids across the United States. "On behalf of the United States Olympic Committee, I'd like to thank P&G for their commitment to youth sports through the USOC's P&G | Team USA Youth Sports Fund," said USOC CEO Scott Blackmun. "Their donations will help develop the next generation of athletes and spread the Olympic Values of excellence, friendship and respect." The USOC's P&G | Team USA Youth Sports Fund was supported through integration across marketing channels including advertising, public relations, in-store merchandising, mobile, digital and direct mail. For more information and assets related to the campaign, visit www.facebook.com/thankyoumom or http://pg-na.isebox.net/us/.About P&G P&G touches and improves the lives of about 4.4 billion people around the world with its portfolio of trusted, quality brands. The Company's leadership brands include Pampers®, Tide®, Ariel®, Always®, Whisper®, Pantene®, Mach3®, Bounty®, Dawn®, Fairy®, Gain®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun®, Fusion®, Ace®, Febreze®, and Ambi Pur®. With operations in about 80 countries, P&G brands are available in more than 180 countries worldwide. Please visit pg.com for the latest news and in-depth information about P&G and its brands. About the USOC The United States Olympic Committee (USOC) is recognized by the International Olympic Committee as the sole entity in the United States whose mission involves training, entering and underwriting the full expenses for the U.S. teams in the Olympic, Paralympic, Pan American and Parapan American Games. In addition to being the steward of the U.S. Olympic Movement, the USOC is the moving force for support of sports in the United States that are on the program of the Olympic, Paralympic, Pan American and Parapan American Games. For more information, visit TeamUSA.org. P&GAnne Westbrook,+firstname.lastname@example.com Rella,+firstname.lastname@example.com


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The Message audio Bible is now available on Bible Gateway! Click to learn more.
55:22 he will never permit the righteous to be moved. The context of the psalm shows that there is no unqualified promise that the righteous will always be happy and prosperous. The psalmist sings this lament to the Lord because he is in despair. The verse must mean that God will not leave the righteous in the fallen position forever, but will vindicate them in the end.


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The DIY movement has surpassed preserving dill pickles and strawberry jam. People are venturing to make their own cheese and cured meats. Salumi: The Craft of Italian Dry Curing by Michael Ruhlman and Brian Polcyn recognized this revival and have written a cookbook dedicated to understanding and reproducing the artisanal sausage at home. The authors are no strangers to the art of curing meat; the duo released Chacuterie: The Craft of Salting, Smoking and Curing in 2005. Salumi provides specific yet simple instructions to demystify Italian cured meats into a doable task. The book outlines eight of Italy's most famous pork products including guanciale, coppa, spalla, lardo, lonza, pancetta, proscuitto, and of course, salami. In addition, there is a section that describes how to butcher an entire pig using both the Italian and American method. Salumi is a fundamental resource for anyone interested in the ancient craft of curing meat.
Salami Felino
Felino is a town in the province of Parma in the heart of Emilia-Romagna. Hogs are said to have populated this area since the Bronze Age, and as the prosciutto of Parma became famous, so too did its salami. It's a simple sausage, dependent on the quality of the pork, seasoned with just salt, pepper, garlic, red wine, and a small amount of sugar for sweetness.
2 pounds/900 grams pork shoulder butt, cut into large dice
2 pounds/900 grams boneless lean beef (chuck or round), cut into large dice
1 pound/450 grams pork back fat, cut into large dice
2 ounces/56 grams sea salt
1 teaspoon/7 grams DQ Curing Salt #2
2 teaspoons/3 grams finely ground black pepper
1 tablespoon/11 grams dextrose
3 garlic cloves, minced
½ cup/125 milliliters chilled dry red wine
1 tablespoon/10 grams Bactoferm (live starter culture; see Sources, page 267)
2 tablespoons/30 milliliters distilled water
Mold 600 (see page 70 for more information and page 267 for sources) (optional)
Two 18-inch/45-centimeter lengths beef middle, soaked in tepid water for at least 20 minutes and rinsed
1. Partially freeze the meat and fat.
2. Grind the pork through a ¼-inch/6-millimeter (medium) die into the bowl of a stand mixer. Grind the beef into the bowl, then grind in the fat.
3. Add the salt, curing salt, pepper, dextrose, and garlic and mix on medium speed with the paddle attachment until the ingredients are well distributed. Add the wine and mix until incorporated.
4. Dissolve the Bactoferm culture in the distilled water, add it to the meat, and mix until it's well distributed and the meat is tacky, another minute or so.
5. Tie one end of each casing using a bubble knot (see page 122). Stuff the sausage into the casings, and tie each one off using another bubble knot. Using a clean needle, sausage pricker, or knife tip, poke holes all over the sausage, especially where there may be air pockets. If you're using weight to determine doneness, weigh the sausages and record the result.
6. Hang the sausage to incubate for 12 hours in a warm place (ideally 80 degrees F./
27 degrees C. and 80% humidity).
7. Hang the sausages in the drying chamber. If using the mold culture, mist them according to the package instructions. The salami are ready when they have lost about 30 percent of their raw weight, about 3 weeks.
Yield: Two 1.75-pound/800-gram salami
Reprinted from Salumi: The Craft of Italian Dry Curing by Michael Ruhlman and Brian Polcyn. Copyright © 2012. With the permission of the publisher, W.W. Norton & Company, Inc."
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Lawrence Wittner: Are we safer with more firepower or less? Despite the propaganda of the gunslingers, the arms manufacturers, and the military enthusiasts, it does seem that the world would be a lot safer with fewer guns and fewer nuclear weapons.
Progressive Media Advocates
Treva Brandon Scharf: Confident people don't bash themselves; they don't let negative thinking and self-loathing screw up a good workout or undermine their progress.
Edward Wasserman: The larger question, to me, was less why she did what she did, but why everybody seemed to care so much, and why her case provoked so much anger.
Joe Mathews: But with immigration flatlining and the climate drying up, it may soon be.


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The moon roof may not close all the way because of a faulty limit switch. The headliner must be removed to replace the limit switch.Google+
Car Problem Reports
Honda Accord Faulty Limit Switch May Prevent Moon Roof From Closing
Honda Accord Problem
Model Years Affected: 2003, 2004
Average Mileage: 104,000 mi (88,000 mi - 130,000 mi)
Visitor, 2003 Honda Accord, 88,000 mi
have to push several of moonroof buttons to get it to close all the way ea time! replaced roof switch on dash but did not help! now I know what fix to do! ty!
Visitor, 2004 Honda Accord, 130,000 mi
First began happening when it was very hot, now it hppens all three time. Moonroof will close most of the way, then stop. Press the tilt button, it then moves the rest of the way, but with the rear edge still in the dropped position. Finally, press the close button again and it then fully closes. Works every time. Mechanic told me he'd need to remove the headliner to repair it.
Visitor, 2003 Honda Accord, 94,000 mi
bought this car used w 88000 miles on it and power moonroof switch only closes roof if I press tilt feature button and then it stops when it is almost closed and I have to then press close switch to finish closing it! pain in the butt! will replacing this limit switch solve both problems? I replaced moonroof swith on dash but no change!


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Thanks for redeeming.{{else}}
Success! Thanks for repurchasing.{{/if}} {{else}} {{#if Expired}}
Increase my visibility!{{else}} {{#if IsMultiPack}}
{{#if HasMultiPack}} You have {{MultiPackCount}} top spot(s) left. Now loading you into the search listings... {{else}} You have used all top spots. Now loading you into the search listings... {{/if}}{{else}}
We are loading you into the search listing pages...{{/if}} {{/if}} {{/if}} {{/if}}
{{Current}} just saw you!{{/if}} {{#if LastTopSpotPurchaseIsMulti }} {{#if HasAnyTopSpot}}
{{#if HasFreeTopSpot }} {{ UnclaimedTopSpotFree }} Free {{/if}} {{#if HasPaidTopSpot }} {{#if HasFreeTopSpot }} & {{/if}} {{ MultiPackCount }} {{/if}} Top Spot{{#if Plural}}s{{/if}} Left{{else}}
0 Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{else}} {{#if HasFreeTopSpot }}
{{ UnclaimedTopSpotFree }} Top Spot{{#if Plural}}s{{/if}} Left{{/if}} {{/if}} {{else}} {{#if HasResults}}
{{Current}} see you now!{{else}} {{/if}} {{/if}}
You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
29 year old man | Orlando, FL, USA | Seeking women 21-30 within 50 miles
Active within 24 hours
If anyone asks, we met at Publix.
Well to start, I don't really like the idea of meeting someone online, but after snooping through my friend's profile a few dozen times I realized I could be missing out on an opportunity, so why not. I'm an Orlando native, born and raised. Now, humor is king. I love to joke around and don't always take myself too seriously when I don't have to so you should at least like to laugh. I'm an outgoing individual who enjoys being around others and social settings. I'm easy going and as long as I'm in good company I'm usually having a good time no matter what the activity. I don't really have "a type", but I would like to find someone who shares common values, interests, outlooks on life, and is fun to be around and spend time with.
Camping , Coffee and conversation , Cooking , Dining out , Fishing/Hunting , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Playing cards , Playing sports , Travel/Sightseeing , Watching sports , Wine tasting
Basketball, Football, Other types of exercise, Running
I exercise 3-4 times per week.
Don't display my sign
I like Dogs
Charleston, New Smyrna Beach, Abacos, the outdoors
College of Charleston, Charleston, SC
It's a long list.
Everybody Poops by Taro Gomi
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|6'0" (182cms)
|5'0" (152cms) to 6'0" (182cms)
|Body type:
|Athletic and toned
|Slender, About average, Athletic and toned
|Black, Blue, Brown, Grey, Green, Hazel
|Dark blonde
|Black, Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way
|Social Drinker
|Social Drinker
|Sales / Marketing
|No preference
|I'll tell you later
|No preference
|Never Married
|Never Married
|Have kids:
|Wants kids:
|Definitely, Someday
|White / Caucasian
|Latino / Hispanic, White / Caucasian
|Christian / Protestant
|Christian / Catholic, Christian / Protestant, Jewish, Spiritual but not religious
|Graduate degree
|Associates degree, Bachelors degree, Graduate degree


text:
Interesting feature here is you can create rosters, so no more player swapping for balance. There is even a warmup period included. Also lots of customization options that can be done via Battelog.
Might help garnering interest in community events?
Game » consists of 15 releases. Released Oct 25, 2011
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text:
By Neo4j Staff | September 15, 2011 Last time Nigel discussed Neo4j, he introduced Py2neo, a binding between Python and Neo4j.
This time, he's back to talk about pagination with Neo and Cypher.
"Fundamentally, the method described here exploits the order by, skip and limit features of Cypher in order to return only a segment of the total results from the overall result set."
He then presents a demo using numbers, with each node containing the numerical value and English name ( "number": 12, "name": "twelve" )
Check out his blog post on pagination, and keep up the great work Nigel!
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text:
The Global FlyFisher - The Largest and Best Place to go for Online Fly Fishing and Fly Tying
GFF Blog
Saturday May 28th 2005
Where'd they go?
Where'd they go?
|Published: Saturday May 28th 2005 (10 years ago)
Updated: Saturday May 28th 2005, 3:41PM
by Martin Joergensen
The previously so abundant Danish sea trout have gone
We had an April out of this world on the Danish coast, and I expreienced fishing for sea trout like I have never done before.


text:
Jun 2015
Foundation Director Named
Nina M. Jones has been named the UW-Washington County Campus Foundation Executive Director. Formerly serving as the Executive Director of the Bel Cantro Chorus of Milwaukee, Jones was chosen from a pool of 19 applicants and will begin her duties...
Spring Dean's List Announced
The University of Wisconsin-Washington County has named 124 students to the Dean's List for the Spring Semester 2015. These students have achieved academic success by achieving a grade point average (GPA) of 3.50 or higher. Three designations are...
May 2015
UW-WC Students Win Rocket Competition
Two UW-Washington County students recently took first place in the Wisconsin Space Grant Consortium-Collegiate Rocket competition (Non-Engineering Section). Zach Young and Rusty Tillman designed and constructed UW-WC's winning rocket. Advisors...
UW-WC Names Top Athletes
Top awards to UW-Washington County (UW-WC) student athletes were presented by Debbie Butschlick, Athletic Director and Professor Roger Peterson, WCC Faculty Representative at the May athletic banquet held in their honor.
The Robert B. Pick...
Scholarship Awards on May 19
The University of Wisconsin-Washington County (UW-WC) will present over $81,000 in scholarships at the Scholarship Awards Ceremony on Tuesday, May 19, 2015. A reception for scholarship presenters and recipients will be held in the gym prior to...
Graduates Announced
The University of Wisconsin-Washington County will recognize the accomplishments of 150 students at the annual Commencement ceremony on Thursday evening, May 21, 2015. Students, who have recently completed or will be completing their degree...
Commencement is May 21
UW-Washington County (UW-WC) is making preparations for the annual Commencement Ceremony on Thursday, May 21. The accomplishments of UW-WC students will be the main focus, with the awarding of bachelor and associate degrees, over $71,000 in...
Pre-Finals Activities Planned
Thursday, May 14, 2015
Monday, May 11
TEAM BUILDING CONTEST, Win prizes! Two person teams compete using spaghetti, marshmallows and cards. Noon-1pm, Bistro on the Hill, Sponsored by SGA
Apr 2015
May concerts planned
The Music Department at UW-Washington County (UW-WC) is planning two spring concerts. The Moraine Symphonic Band, under the direction of Ryan Meisel, will perform in the campus theatre on Saturday, May 9 at 3pm. Admission is free and no...
Summer Youth Athletic Camps
UW-Washington County will be offering basketball, soccer and volleyball camps this summer. The annual athletic camps for students in kindergarten through 12th grade are a great opportunity for area youth to hone their skills on the court and...
- 1 of 34
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text:
Hear state on cuts to coal, EPA asked
Posted: June 12, 2014 at 4:41 a.m.
Arkansas' U.S. House delegation asked the Environmental Protection Agency on Tuesday to visit the state and listen to local concerns about a plan to require cuts in carbon emissions.
This story is only available from our archives.
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J.A. Fair lists 1st, 2nd in 2014 class
Darielle Brown, 18, graduated valedictorian of J.A. Fair High School in the Little Rock School District. Read »
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19 in Searcy County arrested in drug sting
Police on Wednesday began arresting 22 people named in drug-related arrest warrants in Searcy County as the result of a months-long operation called Summer Ice. Read »