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Archie Comics: Cheryl Blossom
Cheryl Blossom #35
"Phantom of the Fun House" A stroll on the beach with Archie and the gang leads to an amazing discovery-- a defunct boardwalk amusement park! Curious, the teens check it out. Have they stumbled upon a haunted ghost park? The answer will thrill and chill you!
Cheryl Blossom #34
"Midsummer's Magic" It's "rich meets witch" when Sabrina the Teenage Witch guest-stars! A chance sighting on the beach leaves Jason love-struck, but Cheryl feels other emotions as she flashes back to the time she and Sabrina were in summer camp together! Will Cheryl be able to face her haunted past?
Cheryl Blossom #33
"Something Fishy" Cheryl meets a hunky marine biologist on the beach, but the only body he's interested in is a body of water!
Cheryl Blossom #32
"Bug Off!" Things get hairy when Cheryl gets into the "bug clip" craze! "Gopher Broke!" Cheryl has her own "war of the roses"-- or should we say "rodents", when a gopher devours her garden!
Cheryl Blossom #31
"In Your Dreams" When Cheryl finds herself constantly dreaming about Jughead, she quits eating cold pizza before bedtime. When the dreams continue, however, she's really in a dilemma. Could she possibly be in love with Jughead?
Cheryl Blossom #30
"C'est Le Ski" After a full year of touring, the hot, all-girl singing group B*Magic is looking forward to fun and relaxation at the ski lodge, but Cheryl has something else in mind-- namely, a photo spread of the group's vacation. Using her every ounce of "journalistic integrity", Cheryl attaches a micro-camera to her puppy Sugar's dog collar! Will Cheryl get the pictures she wants, or just another lesson in consideration?
Cheryl Blossom Special #3
"All I Want for Christmas is... Everything!" The title says it all as Cheryl shows no restraint on her Christmas wish list! Convinced by her parents that giving is more rewarding than receiving, Cheryl reluctantly decides to give her visiting cousin a makeover. Cheryl's reward: her cousin is "wowing" all the guys in sight!
Cheryl Blossom Special #2
"Life's A Circus" Cheryl falls (no pun intended) for a trapese artist. Betty and Veronica, still hurting from Cheryl's pursuit of Archie, decide to get a little revenge and make their own advances towards the handsome hunk! All's fair in love and war... even at the fair!
Cheryl Blossom Special #1
This is it! The first Cheryl Blossom Special, coming hot on the heels of Cheryl's shocking return to Riverdale in the Love Showdown saga! Betty and Veronica are more determined than ever to hold their ground where Archie's affections are concerned!
Cheryl Blossom #29
To Catch A Falling Star" Cheryl is livin' la vida loca-- literally-- when she tries to snag an interview with elusive pop star Richie Marvin for her fashion magazine! She'll have to get through his bodyguard, however. What is Richie's secret, anyway-- and why is he keeping it from the public? If we know Cheryl, she'll get all the answers and then some!
Cheryl Blossom #28
"Holi-Daze" 'Tis the season to try to outdo each other with elaborate holiday parties-- at least for Cheryl and Veronica! Will they deck the halls-- or each other?! Looks like a job for everyon'e favorite angel, Betty!
Cheryl Blossom #27
"It's A Maze Thing" At an ourdoor charity function, Cheryl wanders into a garden maze. Imagine her surprise when she bumps into her rival, Veronica! Worse yet, they're both lost! A strange alliance blooms as these two team up to find their way out. Can they make their way out?
Cheryl Blossom #26
"Take The Mummy and Run" Move over, Cleopatra-- Cheryl intends to be the queen of the gala opening of the museum's new Egyptian wing!And she wouldn't mind being the queen of Dr. Carter-- the reknowned archeologist who's a consultant to the collection. The good doctor may not be all he seems, jowever, and it may be too late before the Blossoms realize "egypt" 'em!
Cheryl Blossom #25
"Creature Feature on Party Beach" When low-budget horror movie maker Rick Goreman stumbles upon Cheryl's beach party, he comes up with a money-saving idea--set up hidden cameras and film the kids as they find his "haunted" pirate ship!
Cheryl Blossom #24
"He-Mail" Could Cheryl have finally fallen in LOVE?! That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new story!
Cheryl Blossom #23
"Friendly Fire" What's this? Cheryl Befriending Betty? Is she sincere, or just trying to get at Veronica... and Archie?! Don't miss the intrigue as Cheryl weaves her wacky, wonderous web!
Cheryl Blossom #22
"Big In Japan" Cheryl goes to Japan to do research for a family-friendly video game her mother is developing. Video games-- and Japan, for that matter-- may never be the same once our radical redhead gets through with them!
Cheryl Blossom #21
"Sugar World" It's musical madness when Cheryl auditions to become the next "Sugar Girl". Will she be a smash, or will her career hit a sour note?! Find out in this issue-length musical extravaganza!
Cheryl Blossom #20
"Cinderblossom" Designing gowns is exhausting-- so exhausting in fact that Cheryl dozes off in the middle of designing gowns for "Fresh" magazine. Deep in dreamland, wealthy, hip Cheryl winds up a poor, put-upon peasant in her very own Cinderella fantasy. Will she wake up "happily ever after"?
Cheryl Blossom #19
"Chill-Out!" Will the winter photoshoot for Cheryl's fashion magazine be really cool, or is she on thin ice? That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new story!
Cheryl Blossom #18
"Strike A Pose!" Fashion is the passion as Cheryl comic gets chic with fashions suggested by readers! In this whirlwind tale, Cheryl proves that maybe she's not a model student, but she could be a model model-- and maybe even a super model!
Cheryl Blossom #17
"Cheryl-Mania!" Cheryl's beach-house TV talk show becomes a natural obsession, as the love lives of both the Pembrooke and Riverdale teens becomes positively public! The spotlight gets way too hot, however, so Chrtyl decides to go out with a bang-- broadcasting one final beach bash as her farewell show! With a Cheryl lookalike waiting in the wings to start her own show, will Cheryl's celebrity status last?
Cheryl Blossom #16
"Lights, Camera, Action!" Continuing from the previous issue's "Cheryl's Beach Bash", the action really heats up when the Riverdale teens invade the beach smack dab in the middle of Cheryl's TV talk show!
Cheryl Blossom #15
"Cheryl's Beach Bash" Ever the publicity-seeking, celebrity chasing ham, Cheryl ends up with her own beachfront talk show. Will jealous brother Jason cancel the show before the network does?
Cheryl Blossom #14
"Cheers To You" Cheryl decides to become a cheerleader, but when she finds out the roster is already filled, she becomes the coach instead! When they set off for their big cheerleading competiton, though, things don't go as planned. Will they make it to the competition on time?
Cheryl Blossom #13
"Spring Blossom!" Will Cheryl successfully chage the Cherry Blossom Festival into a CHERYL Blossom Festival?! That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new story!
Cheryl Blossom #12
"Stop the Presses" Oh my- can it be true? Cheryl now a regular student at Riverdale High? You betcha'-- and just wait until she gets ahold of the school newspaper! When she's through with it, it'll be more like the school tabloid! Find out for yourself whether "Mr Weatherbee's really an alien"-- and other juicy tidbits of "red" journalism as only the most radical redhead of all can deliver!
Cheryl Blossom #11
The thrilling conclusion to a two-part story arc! "Who's That Girl? Part Two" Last issue, Betty and Veronica claimed Archie wouldn't give Cheryl the time of day without her looks, so she got a complete makeover as "Shirley Merriweather". This issue, her charade continues, but danger lies ahead as her scheming brother Jason has learned of her ruse! Will Cheryl succeed at fooling everyone in Pembrooke and Riverdale-- or will Jason expose her as a fraud?
Cheryl Blossom #10
Who's That Girl? Part One" Betty and Veronica claim that Archie wouldn't give Cheryl the time of day without her looks, so she gets a complete makeover as "Shirley Merriweather". Will she pull the wool over their eyes?
Cheryl Blossom #9
"'Tis The Season" What will Cheryl and Jason get for each other this Christmas? Whatever they choose, they won't be able to use their father's credit cards! Will they create a Christmas miracle?
Cheryl Blossom #8
"Masquerade Madness" Who is the intriguing masked man at Cheryl's masquerade ball? That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new story!
Cheryl Blossom #7
"Educating Cheryl!" The Pembrooke girls are getting dating advice from Cheryl! How could things possibly go wrong?! That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new story!
Cheryl Blossom #6
"What A Disaster!" Cheryl's ready for her close-up as she makes her own blockbuster movie! That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new story!
Cheryl Blossom #5
"Cheryl in the Morning" When Cheryl gets a co-hosting spot on the local TV morning show, the AM will never be the same again! That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new story!
Cheryl Blossom #4
"Radio Daze" Radio has a new favorite talk-show host-- Cheryl Blossom! That skick chick that makes the boys flip returns in this all-new story!
Cheryl Blossom #3
"Home Un-Improvement" A home improvement show comes to fix up the Blossom's inn! But with Cheryl around, can things go off without a hitch? That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new story!
Cheryl Blossom #2
"Inn Big Trouble!" Have Cheryl and Jason inherited a haunted inn? That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new story!
Cheryl Blossom #1
The popularity of Cheryl's first solo special led to this, the first issue in her very own series! "Spring Blossom!" That skick chick that makes the boys flip, Cheryl Blossom returns in this all-new, full-length story!


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Originally written on Pro Sports Daily | Last updated 3/1/12
NBC Sports Network analysts Mike Milbury and Jeremy Roenick got into a heated debate on Wednesday night as they discussed whether Eric Nystrom of the Dallas Stars should be suspended for his hit on Pittsburgh Penguins defenseman Kris Letang. Milbury argued that Nystrom should be suspended at least five games for the first-period collision, which ultimately knocked Letang out of the contest. The blue-liner had missed 21 games earlier in the season with a concussion. For his part, Roenick argued that while he loves Letang as a player, he put himself in a vulernable position by lowering his head. The conversation became animated quickly - with Milbury even lightly tapping Roenick across the face to accentuate a point. Roenick responded that Milbury is "getting soft" and should go have a Shirley Temple.
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Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 11.0 PRACTICAL CONSIDERATIONS ..............................................................................11-3 11.1 Transferability of the 3T3 and NHK NRU Test Methods..............................11-3 11.1.1 Facilities and Major Fixed Equipment .....................................................11-4 11.1.2 Availability of Other Necessary Equipment and Supplies ......................11-6 3T3 and NHK NRU Test Method Training Considerations ..........................11-8 11.2.1 Required Training and Expertise ..............................................................11-8 11.2.2 Training Requirements to Demonstrate Proficiency .............................11-10 Test Method Cost Considerations ....................................................................11-11 11.3.1 3T3 and NHK NRU Test Methods .........................................................11-11 11.3.2 In Vivo Rodent Acute Oral Toxicity Testing .........................................11-12 Time Considerations for the 3T3 and NHK NRU Test Methods ................11-14 Summary ..............................................................................................................11-15 11.2 11.3 11.4 11.5 11-1 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 [This Page Intentionally Left Blank] 11-2 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 11.0 PRACTICAL CONSIDERATIONS The 3T3 and NHK NRU test methods are proposed as adjuncts, rather than replacements for, the in vivo acute oral toxicity assays. Data from these in vitro basal cytotoxicity test methods are used with a prediction model to estimate the rodent oral LD 50 of the test chemical. This LD50 value is then used to determine the starting dose for subsequent in vivo acute oral toxicity assays. This section discusses practical issues involved in applying these two in vitro NRU cytotoxicity test methods to the prediction of starting doses for rodent acute systemic toxicity assays. Practical issues to consider for implementation of these cell culture test methods include the need for and availability of specialized equipment, training and expertise requirements, cost considerations, and time expenditure. Good Cell Culture Practice: ECVAM Good Cell Culture Practice Task Force Report 1 (Hartung et al. 2002) encourages the establishment of practices and principles that will reduce uncertainty in the development and application of in vitro test methods. Good cell culture practices (in conjunction with good laboratory practices) are essential for all in vitro cytotoxicity testing and should be employed to ensure that data produced from the 3T3 and NHK NRU test methods are reproducible, reliable, credible, and acceptable. 11.1 Transferability of the 3T3 and NHK NRU Test Methods Transferability of a test method is defined as the ability of a test method or procedure to be accurately and reliably performed in different, competent laboratories (ICCVAM 2003). Accuracy and reliability of these test methods are discussed in Sections 6 and 7, respectively. Protocols for the 3T3 and NHK NRU test methods, solubility testing, and prequalification of keratinocyte growth medium have been optimized and are available on the ICCVAM/NICEATM website (http://iccvam.niehs.nih.gov/methods/invitro.htm). The protocols were designed with GLP-compliance in mind and can be easily implemented or adapted by scientists with the appropriate technical experience. 11-3 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 While in vitro and in vivo methods require some similar skills (e.g., preparation of solutions and test chemical doses, documentation), in vitro testing requires skills specific to cell culture systems (e.g., aseptic techniques, microscopic evaluation of cell cultures, propagation of cells in medium) but not to the maintenance, handling, or treatment of rodents. 11.1.1 Facilities and Major Fixed Equipment The following lists of facility requirements, equipment and supplies, and training and expertise are common to most in vitro mammalian cell culture laboratories. Required equipment and supplies are also described in the NICEATM/ECVAM validation study 3T3 and NHK NRU test method protocols (Appendices B and C), the Guidance Document (ICCVAM 2001b, Appendix D) and Hartung et al. 2002. Facility Requirements The testing facility should provide structures and infrastructures necessary for operating a scientific laboratory (e.g., laboratory space, access to utilities, shipping/receiving department [for appropriate receipt and handling of cell culture materials], etc.). Each facility should provide: personnel that are competent in performing in vitro cytotoxicity assays under aseptic laboratory conditions adequate facilities, equipment, and supplies proper health and safety guidelines satisfactory quality assurance procedures Each facility should conform to all appropriate statutes (i.e., local, state, provincial, federal, national, international) concerning safety guidelines (e.g., general workplace safety guidelines, chemical handling and disposal guidelines, biohazard guidelines, etc.). Hartung et al. 2002 provides recommended safety guidelines for working with potentially infectious materials (e.g., HIV, hepatitis B, hepatitis C) and human materials (e.g., cells, tissues, fluids). The facility management should establish scientific guidelines and procedures, train and supervise professional and technical staff, and evaluate results and performance within their 11-4 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 discipline area relative to the testing requirements. Personnel should have mandatory training in basic cell culture practice, in specific procedures for specialized culture procedures, and in specific safety practices appropriate to the types of materials that may be used in the laboratory (Hartung et al. 2002). The management should maintain records of the qualifications, training and experience, and job descriptions for each professional and technical individual involved in the testing. Cell Culture Laboratory The testing facility should have a designated cell culture laboratory to ensure that in vitro cytotoxicity assays are performed under clean and proper aseptic conditions. The laboratory should be located such that through traffic is minimal to reduce possible disturbances that may compromise the cell culture assays. Room temperature of the laboratory should be regulated, monitored, and documented. Access to the laboratory and test chemicals should be restricted to appropriate personnel. Major Equipment Each testing facility should have at a minimum the following equipment: incubator (37ºC ± 1ºC, 90% ± 10% humidity, 5.0% ± 1% CO 2/air) laminar flow clean bench/cabinet (standard: "biological hazard") inverse phase contrast microscope 96-well plate spectrophotometric plate reader equipped with 540 nm 10 nm filter (if testing in 96-well plates) autoclave refrigerator freezer (-70ºC) liquid nitrogen cryogenic freezer/storage unit computer Equipment maintenance and calibration should be routinely performed and documented as per GLP guidelines and testing facility procedures. 11-5 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 General Cell Culture Materials and Supplies The following supplies are needed for the NRU test methods: tissue culture plasticware glassware sterile filtration systems culture medium and supplements serum balanced salt solutions NRU assay chemicals Equipment maintenance and calibration should be routinely performed and documented as per GLP guidelines and testing facility procedures. These types of equipment are available from scientific and laboratory supply companies (e.g., Fisher Scientific, Thomas Scientific, etc.). 11.1.2 Availability of Other Necessary Equipment and Supplies General Equipment Each testing facility should have at a minimum the following equipment: centrifuge waterbath pipettors balance pH meter cell counting system water bath sonicator magnetic stirrer vortex mixer antistatic bar ionizer 11-6 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 Cell culture supplies are generally available through the major scientific and laboratory supply companies and through specialty companies (e.g., GIBCO, SIGMA-Aldrich, CAMBREX/Biowhittaker, Becton Dickinson, etc.). Compositions of culture media, supplements/additives, salt solutions, NRU assay chemicals and the volumes needed for the test methods should be defined. All culture vessels needed to assure proper cell propagation should be defined. During this study, obtaining an adequate supply of NHK medium was problematic for FAL. Communication between the UK distributor and the laboratory was uneven and the SMT intervened on several occasions in an attempt to resolve the supply issue. This illustrates the need for additional sources of keratinocyte cell culture medium. Periodically, it was also difficult to obtain NHK medium and supplements that adequately supported keratinocyte growth similarly in all the laboratories. Although the purchased medium met the manufacturer's QA/QC standards, certain lots of the medium and supplements did not support the growth of NHK cells to the extent needed to meet the growth characteristics required by the test method protocol. This necessitated the need to incorporate an NHK medium prequalification protocol into the study. Prequalification of medium is recommended to avoid unnecessarily repeating studies. Cell Cultures 3T3 Mouse Fibroblasts: BALB/c 3T3 cells, clone 31, can be obtained from national/international cell culture repositories (e.g., CCL-163, American Type Culture Collection [ATCC], Manassas, VA). Normal Human Epidermal Keratinocytes (NHK): non-transformed keratinocyte cells from cryopreserved primary or secondary cells can be obtained from national/international cell culture repositories (e.g., CAMBREX Bio Science, 8830 Biggs Ford Road, Walkersville, MD) or isolated from donated tissue (using proper collection, preparation, and propagation techniques). 11-7 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 Obtaining adequate supplies of keratinocytes may be difficult since preparing a pool of cells depends on the availability of tissue donors. Procurement of a commercially available stock pool of cells and storing them indefinitely in a cryogenics freezer is recommended. 11.2 3T3 and NHK NRU Test Method Training Considerations 11.2.1 Required Training and Expertise Hartung et al. 2002 recommends that scientists involved in in vitro testing should have training in basic cell culture aspects such as: sterile technique, handling culture media, feeding cultures, cell counting, subculture (trypsinization), detection and elimination of contamination, growth parameters, growth curves, viability assays, storage and freezing/thawing of cells. Additionally, training is encouraged for special culture procedures such as: primary cell and tissue cultures, toxicity testing, viability assays, cloning, transfection, expression cloning, cell transformation and immortalization, and virus propagation and isolation. Laboratory personnel should be trained in the application of GLP requirements (see Section 8.1.1). Training and Expertise In vitro NRU cytotoxicity test methods require personnel trained specifically in sterile tissue/cell culture techniques and general laboratory procedures. Performance of the test methods requires a relatively moderate degree of technical capability and a high degree of skill in monitoring and maintaining appropriate cell growth conditions, troubleshooting potential and real problems in culture systems, and interpreting and analyzing cytotoxicity data. Each individual engaged in the conduct of or responsible for the supervision of a study shall have education, training, and experience, or combination thereof, to enable that individual to perform the assigned duties. The NRU test methods do not require that personnel be trained to perform in vivo testing. Specific Training and Expertise Needed for the In Vitro NRU Cytotoxicity Test Methods Personnel involved in performing the in vitro NRU cytotoxicity test methods should be well experienced in general cell culture techniques and should be able to: 11-8 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 work with cryogenic freezing apparatus pipette solutions with large volume pipettors and multi-channel pipettors establish cells in culture vessels under aseptic conditions and monitor growth; recognize normal and abnormal cell growth characteristics; document observations of cell cultures throughout all aspects of the cultures perform the in vitro assays by following the protocols to: grow the cells, treat the cells with test chemicals, perform the NRU assay, measure endpoints (i.e., optical density measurements), transfer data to electronic templates operate equipment necessary for maintaining cell culture laboratories (e.g., incubators, biohazard hoods, spectrophotometric microtiter plate readers) General Laboratory Expertise Needed for the In Vitro NRU Cytotoxicity Test Methods Personnel should also be able to perform and understand basic laboratory techniques and laboratory management: prepare cell culture solutions (e.g., culture medium, NRU solutions); measure pH; know proper storage conditions and maintain proper documentation prepare test chemicals for application to cell culture test plates; follow solubility protocols to adequately prepare test chemicals in solution; recognize solubility issues (e.g., insolubility nature of chemical, precipitation) and implement mechanical procedures for solubilizing the test chemicals monitor and control laboratory room conditions (e.g., temperature, humidity, lighting, traffic); maintain equipment at conditions essential to cell cultures (e.g., temperature, humidity, gas flow, calibrations) Personnel Needed to Perform the In Vitro NRU Cytotoxicity Test Methods Study Director: the single point of study control; has the overall responsibility for the technical conduct of the testing (e.g., GLP adherence); determines test acceptance, provides SOPs, interprets and analyzes the data, documents testing aspects, and produces all written reports. Quality Assurance Officer: monitors the testing to assure conformance with GLP requirements; must be independent of the Study Director. 11-9 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 11.2.2 Laboratory Technician(s): individuals trained in sterile tissue/cell culture techniques and general laboratory procedures and capable of performing the in vitro NRU cytotoxicity test methods in a GLP-manner. Training Requirements to Demonstrate Proficiency Laboratories set their own criteria for proficiency, but in general, personnel should be able to understand the protocol, carry out the protocol with guidance from an experienced supervisor/trainer, and then carry out the protocol with no supervision. An experienced supervisor determines when a technician is adequately trained since there is no precise level of training that can be measured. Once the technician demonstrates competence in executing all the aspects of the in vitro NRU cytotoxicity test method(s), it is appropriate to initiate routine assessments of observations among personnel using a benchmark control test substance (SLS for these two NRU test methods) to ensure consistency. The laboratories in this study were experienced in performing in vitro cytotoxicity assays but were required to train and develop additional skills through Phases I and II (e.g., data collection and transfer to Excel and PRISM templates). Inexperienced laboratory personnel were trained by completion of "training" NRU assays using SLS. In the early phases of the ICCVAM/ECVAM validation study, the laboratories continued training by the testing of coded reference chemicals of various toxicities and performing solubility testing on the chemicals. This training improved proficiency among the staff of the laboratories for the final phase of the validation study. GLP-Compliance Proficiency Criteria ECBC and IIVS conducted this study in compliance with GLP Standards (see Section 8.1.1). The appropriate QA unit (as per GLPs) reviewed the various aspects of the study and issued a QA statement that identified whether the methods and the results described in the Final Report accurately followed the test method protocol and reflected the raw data produced during the study, respectively, and provided assurance that all testing was done under the principles of GLP. FAL (non GLP-adherent) followed GLP standards referenced in Section 11-10 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 8.1.1 as guidelines for conducting this study. FAL had no QA unit to judge their compliance with GLP guidelines. 11.3 Test Method Cost Considerations 11.3.1 3T3 and NHK NRU Test Methods Laboratory Costs Supplies such as cell culture chemicals, the reagents used to measure NRU, and cell culture plasticware are available from numerous suppliers and are not cost prohibitive. Major instruments and equipment that in vitro cytotoxicity laboratories need to implement the in vitro NRU cytotoxicity test methods are described in Section 11.1.1. The 3T3 NRU test method is generally less expensive to use than the NHK NRU test method. One vial of the immortalized 3T3 cells ($180) can be propagated indefinitely by passaging cells and periodically cryopreserving pools (i.e., numerous vials of cells). NHK cells require a fresh sample of primary cells for each test run ($380 per vial). Since primary NHK cells are only passaged once after initiating into culture, there are no cells available to cryopreserve a stock pool of cells. The D-MEM medium used for the 3T3 cells is less expensive, more "generic", and more readily available than keratinocyte-specific medium. (See Table 11-1) 11-11 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 303 304 Table 11-1 Costs for Cell Culture Materials and Commercial Laboratory In Vitro Cytotoxicity Testing Item Cost (approximate) $180/vial 1 Number of Tests Possible indefinite Other One vial can produce an indefinite supply of cells by propagating the cells in culture and periodically freezing a pool of cells. Since cells are passaged only once beyond cryopreservation, new ampules should be thawed frequently to maintain continuous testing. Establish cells in culture (~20 mL/vial of cells; 60 mL/3 vials), seed cells in 96-well plates (12 mL/plate; 180 mL/15 plates); prepare stock solution and eight concentration dilutions (~20 mL/chemical; 300 mL/15 plates). Same as DMEM (above) in vitro NRU cytotoxicity test (24hour test period) in vitro NRU cytotoxicity test (48hour test period) in vitro NRU cytotoxicity test (48hour test period) 3T3 Cells NHK Cells $380/vial1 ~5 (96-well plates) Dulbeccos' Minimum Essential Medium (DMEM) with supplements NHK Medium with supplements Commercial Laboratory Testing (MB Research Laboratories) Commercial Laboratory Testing (Institute for In Vitro Sciences)) Commercial Laboratory Testing (Institute for In Vitro Sciences)) 1 catalogue price 2 personal communication $20/500mL1 ~15 (96-well plates) $80/500 mL1 $1050/$1950 (USP/ISO) per 3 test materials2 $1120 (GLP) per test material (minimum of 5 materials)2 $1850 (GLP) per single test material2 ~15 (96-well plates) 1 test/material 1 range finder, 2 definitive tests per test material 1 range finder, 2 definitive tests per test material 305 306 307 308 309 310 311 312 313 314 315 316 317 318 Commercial Testing Laboratories A representative of MB Research Laboratories (Spinnerstown, PA, http://www.mbresearch.com/) provided a quote (personal communication 2005) for an in vitro NRU cytotoxicity test (24-hour [and not a 48-hour] test period) of $1050/$1950 (USP/ISO) per set of three test chemicals. The lead laboratory for the NICEATM/ECVAM study, IIVS (Gaithersburg, MD, http://www.iivs.org/) provides commercial laboratory GLPcompliant testing using this study's protocols (48-hour test period) at a cost of $1120 - $1850 per chemical/sample (personal communication with Hans Raabe [IIVS] 2005). 11.3.2 In Vivo Rodent Acute Oral Toxicity Testing Table 11-2 provides commercial prices for acute oral systemic toxicity testing. 11-12 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 Bio Research Laboratories (BRL) performs the Acute Oral Rat Toxicity Test bioassay to determine the relative acute toxicity of an unknown substance. The method determines lethality and signs of acute toxicity from a waste sample administered in a single dose by gavage to a limited number of rats. The bioassay determines if the test sample exhibits a median lethal dose (LD50) either greater than or less than a regulatory threshold corresponding to a hazardous waste designation (i.e., 5000, 500, 50 mg/kg). A minimum of ten rats is used at the tested dosage for the pertinent regulatory threshold value that is relevant to the test sponsor. Knowledge of the estimated LD 50 does not reduce animal use or test costs if a single predetermined dose is tested. The President of Product Safety Laboratories (Dayton, NJ, http://www.productsafetylabs.com/), Gary Wnorowski, provided a cost quote of $2700 for determination of an LD50 value using the UDP test; the cost is independent of the number of rats that are needed. Each testing dose is administered ~24-48 hours after the previous dose and each animal test generally does not exceed four days. Time involved in providing the LD50 value is approximately three months (initiation of the test to provision of the final report). Knowing the estimated LD50 value does not affect the cost of the in vivo test in this case but could reduce the number of animals needed for the test. MB Research Laboratories performs the UDP test at a cost of $750 for three rats and charges $250 for each additional rat needed. In the best-case scenario, the UDP test needs only three rats ($750). In the worst-case scenario, this test would need an additional 12 rats (15 maximum for the test); the total cost of the test would be $3750. In this costing strategy, $250 is saved from the total cost of the UDP for each rat saved by using the 3T3 or NHK NRU test method to predict the starting dose. Considering that adding the in vitro NRU cytotoxicity test costs from $350 to $1850 per chemical, the NRU test does not provide cost savings if fewer than two to six animals are saved. 11-13 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 349 Table 11-2 Commercial Prices for Conducting In Vivo Acute Toxicity Testing Test GLP-Compliant $1200 $800 $2700 $950 $1500 Non GLPCompliant $1000 $650 $2200 NA NA Company Product Safety Laboratories (PSL) PSL PSLa Bio Research Laboratories (BRL) BRL 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 $3000 NA BRL $730 for the first 3 Acute Oral Toxicity – UDP animals; $250 each NA MB Research Laboratoriesa additional animal a provided to NICEATM through personal communication b Washington State Biological Testing Methods #80-12 For the Designation of Dangerous Waste; Part B: Acute Oral Rat Toxicity Test [http://www.ecy.wa.gov/pubs/80012.pdf] The method is an adaptation of the EPA Health Affects Test Guidelines OPPTS 870.110 Acute Oral Toxicity and American Society for Testing and Materials (ASTM) methods E 1163-90 (Standard test method for estimating acute oral toxicity in rats) and E 1372-90 (Standard test method for conducting a 90-day oral toxicity study in rats). Acute Oral Toxicity UDP: Limit Test - 2000 mg/kg Acute Oral Toxicity UDP: Limit Test - 5000 mg/kg Acute Oral Toxicity UDP: LD50 Acute Oral Rat Toxicity: single doseb Acute Oral Rat Toxicity: two dosesb Acute Oral Rat Toxicity: LD50 11.4 Time Considerations for the 3T3 and NHK NRU Test Methods The 3T3 NRU Test Method Approximately one week is needed to thaw cryopreserved 3T3 cells, propagate the cells in flasks, and passage/subculture the cells at least two times before subculturing to the 96 -well test plate. After subculture into 96-well plates, the cells are incubated another 24 hours to reach the proper percentage of confluency, and then exposed to test chemical for 48 hours. The entire 3T3 NRU assay process takes approximately 10 days. However, once the cells are established in culture, they can be passaged for approximately two months before starting the initial propagation from frozen stock. Multiple chemicals can be tested at the same time, and different tests can overlap each other; thus, many chemicals can be tested in a relatively short time. The NHK NRU Test Method Approximately one week is needed to thaw cryopreserved NHK cells, propagate the cells in flasks, and passage/subculture the cells (once) directly to the 96-well test plate. After subculture into 96-well plates, the cells are incubated another 48-72 hours to reach the proper 11-14 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 percentage of confluence and then exposed to test chemical for 48 hours. The entire NHK NRU assay process (range finder or definitive test) requires approximately 11-12 days. Cells can be seeded at different densities in the culture flasks so that passaging the cultures can take place on different days. Once the cells are established in culture, they are passaged once to the 96-well test plates. Multiple chemicals can be tested at the same time, and different tests can overlap each other; thus, many chemicals can be tested in a relatively short time. In Vivo Testing According to guidelines for acute oral toxicity testing for the main test and limit dose test, single animals or groups of animals are dosed in sequence, usually at 2-4 day intervals, and observations are generally made for up to 14 days (for animals that are not moribund) (EPA 2002a; OECD 2001a; OECD 2001b, OECD 2001c). The addition of NRU testing to estimate a starting dose prior to the implementation of the UDP main test or limit dose test will take 10-12 days, but could save up to 14 days of observation for every animal saved. 11.5 Summary All equipment and supplies are readily available. Direct communication with the NHK medium supplier assured that specific lots of medium were available to the laboratories. The test methods should be easily transferable to laboratories experienced with mammalian cell culture methods. Much of the training and expertise needed to perform the 3T3 and NHK NRU test methods are common to all mammalian cell culturists. Additional technical training would not be intensive since there are no extraordinary techniques needed and these test methods are similar in general performance to other in vitro mammalian cell culture assays. GLP training should be provided to technicians to ensure proper adherence to protocols and documentation procedures. Price levels for commercial testing for one chemical are $1120 to $1850 (Table 11-2) for in vitro NRU cytotoxicity testing to determine the IC50 (IIVS, personal communication) versus $750 - $3750 (Table 11-2) for in vivo rat acute oral testing for LD50 determination. Comparison of costs of the in vitro testing to in 11-15 Draft In Vitro Acute Toxicity Methods BRD: Section 11 17 Mar 2006 405 406 407 408 409 410 411 vivo testing is difficult since the in vitro NRU cytotoxicity test methods are not replacements for the animal testing. Use of these test methods may not necessarily reduce the overall cost of the in vivo rat acute oral toxicity test but can reduce the number of animals needed for a study. 11-16
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I'm confused about where to place JavaScript functions:
When should they be put within the head When inline within the body And, when after the closing html tag?
I'm confused about where to place JavaScript functions:
When should they be put within the head When inline within the body And, when after the closing html tag?
The rules are fast and loose on this, There is no right or wrong way only better and less-better. (well after the
Generally speaking, javascript in the
If you're using a library, or checking for the DOM to be loaded before executing code there's really no issue of where it's placed. However if you're not doing that it's probably better to put it at the end.
Javascript can always be safely placed in the head to make the functionality available to the entire page. Note that this can block loading of the rest of the document, so if you are loading very large or external Javascript, you may wish to load them inline near the end of the body.
Javascript placed inline will become available when executed. This allows you to conditionally load JS when page elements are loaded.
Javascript should always be placed in the
I agree, never seen (nor could I recommend) after html. Also, as noted, blocking is the concern. What I often go with is one script reference in the head to yepnope (an async js loader and testing tid bit (now included with modernizr)), and a tiny block of inline js at the end of the body tag that loads a bootstrap js file.
In that file, I use another yepnope request to load other needed assets asynchronously, and kick off initialization methods.
I've also taken to putting my Google Analytics code in a final yepnope block, so that it's the last thing to load, even after the js app boots.


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Lightless Moor
Last Known Status: Active
Latest Lightless Moor News
Below is our complete Lightless Moor news coverage, including columns and articles pertaining to the band. Some articles listed may be indirectly related, such as side projects of the band members, etc.
Lightless Moor Posts New Track
Lightless Moor is releasing new album "The Poem" today, and in celebration the band has posted a track online for streaming. Check out "Cento Respiri" in the player available below.
"The Poem - Crying My Grief to a Feeble Dawn" sees its release today - September 2nd - via WormHoleDeath / Aural Music Group. The previously posted track "Chained To A Dismal Chant" can also be heard at this location.
Lightless Moor Streaming New Single
Lightless Moor has posted the song "Chained To A Dismal Chant" online, which is the first single from the band's new album "The Poem - Crying My Grief to a Feeble Dawn," being released via WormHoleDeath / Aural Musi cGroup.
The album was recorded and mixed at Realsound Studio in Parma (Italy) with producer Wahoomi Corvi (Crysalys, The Way Of Purity, Haterial), and mastered by Mika Jussila at Finnvox Studios (Finland).
Lightless Moor Posts New Album Trailer
Italy's gothic metal act Lightless Moor recently signed to Massacre Records for the release of new album "The Poem -- Crying My Grief to a Feeble Dawn." A teaser trailer for the album is now available online and can be viewed below.
Additionally, Lightless Moor has just launched a brand new website full of content related to the forthcoming release. Check out the new website right here.
Lightless Moor Signs With Wormholedeath
Italian gothic metal band Lightless Moor has signed a deal with Wormholedeath/Aural Music Group. Wormholedeath will release the debut album titled "Crying My Grief to a Feeble Dawn" worldwide through Aural Music Group.
The album was recorded and mixed at Realsound Studio in Parma (Italy) with producer Wahoomi Corvi (Crysalys, The Way Of Purity, Haterial), and mastered by Mika Jussila at Finvox Studios (Finland). The album will see its release this coming 2013, with further details to come. Lightless Moor comments:
"We are extremely proud to announce the beginning of the journey with Wormholedeath! It is one of the main Italian label, and in addition to the excellent established friendship, we are assured of a great professional work!"
The label also added, "Lightless Moor is a band that we kept under our radar for a long time … They evolved so much during the last year that we decided to offer them a deal. The album is just great and produced by our favourite studio ever, the guys are really honest and nice so they really deserve attention from the scene. We'll do everything possible to make people turn their heads toward this amazing band. I would love to thank the musicians involved in this project for their trust. Cry your grief, Lightless Moor are ready!" More...


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Do you know of any way to use this plugin to display hours for multiple locations? It appears that the hours are set in a central settings page, so we can only set open/close once for each weekday.
It would be nice if there was a way to override those settings within the widget itself, so that we could display multiple widgets (each location has its own business hours). Is that possible with this plugin? Thank you.


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The Lasso: Roping in the best of the web
Updated May 30, 2014 - 3:15 pm
Over-excited speller celebrates too early
Nothing says middle school like awkward moments, nervous kids and spelling bees. This excited eighth-grader just hit the trifecta in this year's National Spelling Bee.
After receiving his word, "kabaragoya", Jacob was so convinced he lucked out with an easy word he began to celebrate a bit too early.
You can only imagine his surprise when he heard the oh-so-dreaded "ding" of the bell and found that his spelling was incorrect.
Luckily, he handled his defeat gracefully and still high-fived all the continuing contestants.
Don't worry, Jacob, there's always spell check!


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Not exactly exhilarating
The first thing I would say about this game is that it just didn't do it for me in terms of immersion and general entertainment. The story progressed slowly with some painfully bad voice acting and dialog, the strategic turn-based combat system made fights seem complicated and drawn out, the "leveling"/stats system was terribly pointless.
The Last Remnant starts off relatively quickly throwing the player into a skirmish between 20 or so characters. The initial impression this left was that the battle system was interesting but as the game progressed I found the battles to be cumbersome and boring. The whole strategic element with deadblocks, raidblocks, interferences, and flank attacks is cool but it makes some battles feel drawn out when larger groups of units start coming together. The action is slowed down and broken up with some nice quick-time events to trigger critical hits but that's about the only thing that kept my attention during the battles.
The story itself starts off slow and really never drew me in. On the first disk, Rush Sykes is on a search for his sister Irinia which leads him to meeting David (the ruler of Althum) who assists him in helping his sister which leads to the second disk where a bad guy named the Conqueror is trying to get his hands on some remnants and some other stuff happened. I sort of just floated through the game without growing interested with any of the characters or events. Rush was just an annoying and unlikable character to me and this wasn't helped by the cringe-worthy voice acting. There is an abundance of other characters in this game but it can't really help the case when it's hard to care about any of them.
I didn't particularly enjoy playing through the Last Remnant and I found it to be largely forgetable but it might be worth noting that it runs beautifully on the PC. There is still some minor to moderate texture pop-in but there was hardly any slowdown whatsoever with highest settings on a stock 8800GT with a Q6600 processor and 2 gigs of ram. The game looks nice and there is quite a bit of detail in some areas but overall it's just good to know that it runs much better than it did on the 360.


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Serves 4
Serves 4
Bring water to boil in medium saucepan. Remove from heat. Add tea bags; steep 3 minutes. Remove tea bags; pour tea into pitcher. Add sugar to taste and stir until sugar dissolves. Cool. (Can be made 1 day ahead. Cover and refrigerate.)
Mix fruit in bowl. Divide among four 16-ounce glasses. Pour 1/4 cup wine, then 1 cup tea into each glass. Fill glasses with ice cubes and serve.


text:
Cash in on the break
Make this holiday count with some last minute Christmas job-shopping, says Kate Lovell
What happened next?
Simon Norman worked in a NatWest call centre while studying engineering at Southampton University. But what does he do now?
Features p2
The textiles designer
Launch pad: Claire Harbin, who has a degree in textile and surface design, talks to Miles Brignall
Features p3
Reality check
Liz Olive, 23, is a trainee auditor with the Audit Commission which works with public bodies to promote the beset use of state funding
A string of pearls
Timeless wisdom can set you on the road to success. Karen Hainsworth offers eight top profundities
Ask Rise
I'm on a media course, have done some work experience and aim to get into broadcasting. Do radio staions offer graduate training schemes?
Features p4
Set course
Recycling technology: If you are looking to get into a booming industry, you could do a lot worse than recycling. This is a sector that's already worth £1bn in western Europe - a figure that is set to double over the next decade.
School report: University of Reading
A 60-second guide to osme of the UK's top postgraduate seats of learning
Lisa Maffia
My first boss: Lisa Maffia, singer


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The planned underwater cabinet meeting will take place on 17th October. The purpose, is to highlight – ahead of December's UN climate conference in Copenhagen – the threat rising sea levels caused by global warming pose to this low-lying island state.
The Cabinet, chaired by President Mohamed Nasheed, already a certified diver, will communicate using whiteboards and hand signals.
The Maldivian archipelago, located south west of Sri Lanka, Maldives is consisted of a cluster of 1,200 island and coral atolls which is likely to disappear under the waves if the current pace of climate change continues to raise sea levels.
Most parts of the Maldives are just 1.5m above water. If, according to projections the seal-level rise of roughly 60 centimeters to one metre by 2100, Maldives would be virtually uninhabitable.
Source: AFP via Yahoo news


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Family meetings are regularly scheduled times when family members get
together to share feelings, discuss concerns, and solve problems. Since all
members participate, these meetings help build cooperation and responsibility.
Family meetings help members to work together and:
Schedule frequent family meetings at a consistent time to establish a
routine. One person leads the discussions, and another records the meeting and
reports back at the next meeting. Parents can assume these roles in the
beginning. However, other members of the family should take on a role from time
to time so that no one person is always in charge.
The following items usually are included on the agenda for a family
Last Revised:
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text: It's time to get rid of the stock tires on my Santro. Planning for Change this weekend. We need your help deciding which brand and what kinds are best for Santro. I'm not sure what the current rating of the tires is but you can check and let you know today. New ones without a camera. It will be great if you can increase ground clearance without affecting performance.


text:
Originally posted by fedeykin
The problem with being excited about mineral deposits or some such thing, is that it really doesn't shake any foundations. We already know theres rocks on Mars, and doubtless very many interesting rocks, if your a geologist. But the likelyhood that any kind of geology will bring some useful knowledge that will positively affect our lives is very slim.
Even if it meant we were going to go to Mars to mine it, we wouldn't see that untill we would be very old, and doubtless only a few corporations would profit from it, no one else.
As far as scientific discoveries go that will help us in our daily lives, NASA has discovered more in the actual process of going into space, as opposed to what they have found IN space.
Finding life on Mars is therefore one of the only truely exciting things for a laymen because it would confirm that we aren't alone. This, in my opinion, has more value then any other discovery we can make on Mars because it would shake a lot of ignorance out of the world's population.
We won't have to wait too long to learn the facts. NASA has reportedly said that the news conference on this matter will happen at the meeting of the American Geophysical Union, on Dec. 3rd through 7th, in San Francisco.
Originally posted by PhoenixOD
reply to post by Pumper
We already know there is frozen water on Mars.


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November 20, 2014
LCA Announces Next Lung Love Run/Walk: March 2015 in West Palm Beach!
November 18, 2014
LCA Staffer Discusses Lung Cancer Awareness Month on the Radio
November 17, 2014
LCA Joins Coalition Requesting Increased Funding for Innovation Research
November 12, 2014
LCA Partners on Kentucky LEADS Project to Reduce Burden of Lung Cancer in the State
November 12, 2014
Advice from a Lung Cancer Survivor for Newly Diagnosed
November 10, 2014
Centers for Medicare and Medicaid Services Covering Screening!
November 10, 2014
LCA Volunteers and Event Highlighted in Houston
November 06, 2014
16 Screening Centers Participating in Veterans' Screening Week
November 05, 2014
NJ Advocate Raises Awareness in His Town
November 05, 2014
LCA Partners with Bluebeards Original for Movember
November 04, 2014
Free Screenings for Veterans in Greenville, SC
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Healthwell Foundation Launches New Non-Small Cell Lung Cancer Fund
November 04, 2014
Lung Love Walk Houston Organizer Partners with MD Anderson Doctor to Promote LLW Houston
November 03, 2014
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Countdown to Medicare Screening Coverage Makes This LCAM Special


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Fans ran with it today once the Nick deal happened because he's already turned down condit and lombard this year...what else would there be at WW unless they give him Rory, or dare i say it, Johnny hendricks. Diaz has said from day one he wants big fights...his tune has sorta changed now hes talking about title runs so who knows.
Got a lot of soul searching to do. Sorry to everyone I've let down
Oh I hope he does not get a title shot given to him right away. He is 0-2 recently, well relatively recently anyway hahah. I like the Lombard fight the most but how about Marquardt?
FW-Hominick, Weichel
LW-Stout, Cerrone, Jim Miller
WW-GSP, Fitch, Goulet, Rory
HW-Carwin, Barry, Russow
RRR=the Rhonda Rousey Resistance
classic - "this is the dumbest thing Ive ever heard. thats like me having a picture of Hitler posted, and saying "I dont believe in his politics, but I like to hear him talk" W.Silva>C.Norris
Nate is a great idea. Woodley, Lombard, and I STILL want to see him in a rematch with lawler. Maybe he gets loser of brown lawler. That would be fucking awesome.
You say shark I say hey man, Jaws was never my scene and I don't like Star Wars
Wait, so is Mike Kogan not representing Nick and only Nate?
He's 3-6 in his last nine ufc fights. He shouldn't be sniffing anything other than a seven thru ten ranked fighter. Substance over style. I'm fine with the Silva fight since they're 0-4 lately, just please don't call it a Super Fight. Its entertaining, not super. Nick's lost nearly every meaningful fight he's had. I love to hate the Diaz brothers so I always watch their fights if that makes sense. Their perfect heels. That alone shouldn't put Nick only one or two wins from a title shot. IMHO, Silva would pummel Nick.
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- Articles tagged "intel atom z2560"
Hands-on: ASUS's New Android Tablets at Computex 2013 (Updated with Videos)
ASUS announced four new Android tablets at Computex 2013. Join us as we take a closer look at the four tablets.
- Leaked schematics reveal Apple iPhone 6S to be slightly thicker at 7.1mm
- Render of Samsung Galaxy Note 5 leaked in video, shows no removable battery
- GoPro unveils the S$590 Hero4 Session, its smallest and lightest camera yet
- Sony to launch Xperia Z5, Z5 Compact and Z5 Ultra in September?
- Xiaomi Redmi 2GB RAM model launching Tuesday for $179; price slashed for original model
- Mozilla begins external testing of MozVR, new VR-based Firefox browser
- Xiaomi's next low-cost wearable will monitor your heart rate
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London, 24th April, 2009 – NYSE Technologies, a global leader in low-latency market data connectivity delivery solutions, today announced that the SIX Swiss Exchange (SIX) has selected the Exchange Data Publisher (XDP) as its data delivery solution. XDP has a unique suite of software components designed to ensure innovative exchanges and other liquidity pools meet their market data delivery challenges.
The launch of XDP is the result of more than two years of collaboration between SIX and the NYSE Technologies' Exchange Solutions Division. XDP leverages NYSE Technologies' core high-speed market data technology to offer a highly robust, scalable and flexible solution to data management and delivery.
SIX Swiss Exchange have introduced the SWXess Trading Platform to deliver greater capacity, reduce latency and facilitate increased levels of algorithmic trading. SIX is using XDP to provide the SWXess Market Data Service (MDS) module. XDP acquires market data from SIX's internal systems, normalizes and groups it then quickly and reliably distributes it to SIX members. It also provides the operational and maintenance components for monitoring and control, in addition to a framework for delivering new 'service packages' quickly and easily to the market.
With XDP, liquidity providers can utilize an off-the-shelf infrastructure to deliver data in a variety of protocols and formats including NYSE Technologies' Universal Trading Platform Market Data format. Its module architecture supports the addition of value-added content, new products and advanced bandwidth management features. XDP also fully supports NYSE Technologies new cutting-edge Data Fabric middleware to super-charge performance.
"Continuing to find ways to improve our services and extend our capabilities is of paramount importance to SIX," said Chris Landis, Head of the Information Technology Division at SIX. "Working with NYSE Technologies to implement the Exchange Data Publisher (XDP) allows us to move forward with the confidence that our market data infrastructure can process rapidly growing market volumes while maintaining extraordinarily low latency."
"The consistent rise in global market data volumes, programmatic trading and fragmented liquidity all fuel the need for ultra-low latency, flexible data management and a scalable market data delivery strategy. Exchange Data Publisher (XDP) allows exchanges to meet these demands today and plan for tomorrow," remarked Stephen Morrow, VP Exchange Solutions at NYSE Technologies. "We will continue to collaborate with innovators like SIX to ensure that our solutions meet the challenges of this rapidly evolving marketplace."
Notes to Editors
About SIX Swiss Exchange
SIX Swiss Exchange is a subsidiary of SIX Group. On a worldwide scale, SIX Group offers first-rate services in the areas of securities trading, clearing and settlement, as well as financial market information and payment transactions.
About NYSE Technologies
About NYSE Euronext
Cautionary Note Regarding Forward-Looking Statements


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You are a fan of gallery scrapkits ? Come to discover the best forums gallery scrapkits on the internet and share your experience with a community fan of gallery scrapkits . You can also build a forum gallery scrapkits and create your online discussion.
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research guide
editors & contributors
write the editor
The works of García Lorca, internationally recognized as Spain's most prominent lyric poet and dramatist of the twentieth century, are filled with thinly veiled homosexual motifs and themes.
There has always been homosexual involvement in American musical theatre and a homosexual sensibility even in straight musicals, and recently the Broadway musical has welcomed openly homosexual themes and situations.
Best known for his genius in art and architecture, Michelangelo was also an accomplished author of homoerotic poetry.
The African-American gay male literary tradition consists of a substantial body of texts and includes some of the most gifted writers of the twentieth century.
Combining elements of incongruity, theatricality, and exaggeration, camp is a form of humor that helps homosexuals cope with a hostile environment.
Langston Hughes, whose literary legacy is enormous and varied, was closeted, but homosexuality was an important influence on his literary imagination, and many of his poems may be read as gay texts.
James Baldwin, a pioneering figure in twentieth-century literature, wrote sustained and articulate challenges to American racism and mandatory heterosexuality.
Oscar Wilde is important both as an accomplished writer and as a symbolic figure who exemplified a way of being homosexual at a pivotal moment in the emergence of gay consciousness.
Larry Kramer.
Congratulations to playwright and activist Larry Kramer and architect David Webster who were married on July 24, 2013 in a New York City hospital room. The ceremony took place in the intensive care unit of New York University's Langone Medical Center, where Kramer has been recovering from surgery for a bowel obstruction.
As reported by Patrick Healy in the New York Times, the couple's original plan was to be married on the terrace of their Greenwich Village apartment with only two witnesses and the officiant, Judge Eve Preminger, in attendance. But that plan was scrapped when Kramaer was hospitalized. Two dozen friends and relatives attended a noontime ceremony in the intensive care unit.
The two men, who dated in the 1970s and have been partners since the mid-1990s, exchanged Cartier rings and extemporaneous vows.
Playwright, novelist, and essayist, Kramer is now best known for his AIDS activism, which included helping found the Gay Men's Health Crisis and the AIDS Coalition to Unleash Power (ACT UP), as well as for excoriating essays denouncing the failure of government to respond to the AIDS epidemic.
Kramer's best-known plays, The Normal Heart (1985) and The Destiny of Me (1992), chronicle the personal and political responses to the AIDS epidemic, lacerating both the local and national governments for ignoring the devastation of the gay community by the disease.
The Normal Heart won a Tony Award for best revival of a play on Broadway in 2011. A film version of the play is currently underway.
In 2013, Kramer was voted a special Tony for humanitarian contributions.
In the video below, Kramer speaks about the founding of ACT-UP.
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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
30 year old man | Hiram, GA, USA | Seeking women 18-35 within 50 miles
Sports, Movies, & Hopefully you(but not in that order)
Let's see... what to write here that won't make me sound to much like a nerd... well I guess I blew it with that first sentence, but I am originally from New York, and way too obsessed with my sports teams the Yankees, Giants, Knicks, and Syracuse. The other thing I am very passionate about is movies, I love to watch them, and I love to write them in the hopes that someday I will sell a screenplay. I also enjoy playing video games, but I am not obsessed with them, and I like listening to 80s rock music, and I just simply like to always have as much fun and good times as possible. I always like just going out and doing whatever cause I know anything can be a good time if you just have the mind to have fun.
Dining out , Movies/Videos , Performing arts , Playing cards , Playing sports , Shopping/Antiques , Travel/Sightseeing , Video games , Watching sports
Golf, Walking / Hiking
I exercise 1-2 times per week.
I have Cats
I like Dogs
I would have to say the two things I am most passionate about are sports and movies. I also enjoy playing video games and going out, doing anything that is fun, and just an overall good time.
I enjoy watching sports and going to the movies. I also like playing video games, and just going out and having a good time.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'10" (177cms)
|5'0" (152cms) to 5'11" (180cms)
|Body type:
|About average
|Slender, About average, Curvy, Athletic and toned
|No preference
|Light brown
|No preference
|No Way
|No Way, Yes, but trying to quit
|Never, Social Drinker
|I'll tell you later
|No preference
|I'll tell you later
|No preference
|Never Married
|No preference
|Have kids:
|No preference
|Wants kids:
|Definitely, Someday
|White / Caucasian
|Asian, Black / African descent, East Indian, Latino / Hispanic, Middle Eastern, Native American, Pacific Islander, White / Caucasian
|Christian / Protestant
|No preference
|Bachelors degree
|No preference


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It's tough to remember when it first began, because we've been living by this mantra since the beginning here at Fab. The Make Mistakes tee is a reminder of the most important lesson of all. (As long as you learn something from it, that is.)
Reguar fit. Printed on American Apparel 50/50 cotton-poly blend.
Love tees? So do we. Find out the history behind your favorite garment on our blog.
Enjoy 10% off your first order*


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Need to know: CV cliches Why you can`t find a jobHF interviews
It's a well-known stereotype that farmers always complain about the weather.
In Australia, where they have to deal with swings in climate of almost Biblical proportions—including fire, drought, floods and hail – they may have more justification than most.
But for now, at least, it seems soaring grain prices and better weather has finally given growers Down Under something to smile about, according to a quarterly study released on Monday.
Deal Journal Australia is an up-to-the-minute take on the deals and deal makers that shape the Australian landscape, including mergers and acquisitions, capital raisings, private equity and debt markets. In short, wherever money changes hands. Deal Journal Australia is updated throughout each trading day with exclusive commentary, analysis, data, news flashes and profiles. The Wall Street Journal's Gillian Tan is the lead writer, with contributions from other Journal and Dow Jones reporters and editors. Send news items, comments and questions to firstname.lastname@example.com.
Content engaging our readers now, with additional prominence accorded if the story is rapidly gaining attention. Our WSJ algorithm comprises 30% page views, 20% Facebook, 20% Twitter, 20% email shares and 10% comments.
FINS has become a part of DHI in order to improve your job search experience. eFinancialCareers will provide you with the best possible service, the best job opportunities and editorial content and the best talent. With our long track record of helping finance professionals develop their career, from graduating to landing top positions in the industry, we will continue to deliver.
For technology jobs outside the financial industry users can visit Dice.com


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BluePopsicleMember Since 15 Sep 2012
Offline Last Active Jan 04 2014 06:30 PM
About Me
I'm the husband to a wonderful and supportive wife, and the father to 3 great kids. In my spare time I enjoy sitting on the couch and watching TV with my wife. Modeling is my hobby and I love it. I'm not very good at scratch building things so I try to keep things "box stock". However, I take pride in my paint jobs. I love being creative with my colors and designs and hope others enjoy it too.
Community Stats
- Group Members
- Active Posts 418
- Profile Views 2,065
- Member Title MCM Avid Poster
- Age 36 years old
- Birthday May 1, 1979
Full Name
Jon Steele
Previous Fields
Are You Human?
Scale I Build
1:24 / 1:25


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Submitted by bfaye on October 6, 2012 - 1:39am
Suns.com catches up with guard Goran Dragic to ask him about this week's training camp experience in San Diego.
Johnson Raises Eyebrows at Training Camp
Posted: October 5, 2012
During this week's Suns training camp in San Diego, no player has been more magnetic to watch then Wesley Johnson.
The 6-7 swingman, who arrived in Phoenix via trade this offseason, has been captivating with his athletic swoops to the basket, impressive dunks and lights-out accuracy from long range. When Minnesota selected Johnson with the fourth overall pick in the 2010, this was the player they were hoping to see on a regular basis.
Training Camp: Behind-the-Scenes
Submitted by bfaye on October 4, 2012 - 2:18pm
Suns.com provides a behind-the-scenes look at this week's training camp in San Diego.
Former Superstar Aligns With the Suns
Posted: October 4, 2012
When filling out a job application to work in the NBA, having "Hall of Famer" on your resume will typically get you in the door.
At least it did for Ralph Sampson. The former NBA All-Star center and future 2013 Naismith Memorial Basketball Hall of Fame inductee has signed on to become a member of the player development department at the Suns.
Training Camp: Brown on Day 3
Submitted by bfaye on October 4, 2012 - 1:41pm
Suns.com catches up with guard Shannon Brown to ask him about this week's training camp.
Training Camp: Gentry on Day 2
Submitted by bfaye on October 4, 2012 - 12:16am
Suns.com catches up with Alvin Gentry to ask him about this year's training camp.
Training Camp: Michael Beasley
Submitted by bfaye on October 4, 2012 - 12:11am
Forward Michael Beasley discusses his first training camp as a member of the Phoenix Suns.
Camp has Different Vibe Without Frye
As soon as the name was brought up, Goran Dragic's eyes dropped to the floor and his voice sunk a little lower.
It was almost instantaneously apparent that the Suns' new point guard, a person who usually carries himself in a very upbeat way, was sad to begin discussing what happened to his friend and teammate, Channing Frye.
Training Camp: Wes Johnson
Submitted by bfaye on October 3, 2012 - 2:26pm
Suns forward Wes Johnson discusses what his first training camp as a Sun has been like.
Training Camp: Markieff Morris
Submitted by bfaye on October 3, 2012 - 1:31pm
Suns forward Markieff Morris discusses training camp and reveals his favorite way to pass the time away from the court.


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Day Trip to Gruyères including Golden Panoramic Express Train
- Free snacks included
- Comprehensive tour of the city
- Free drinks included
- Rail Tour
Then you will have some free time in the village of Gruyeres to relax or visit his castle overhanging the entire Gruyere region. Next we will catch the Panoramic Golden Express, this train passes above the Lake Leman and permits to enjoy the panoramic view on the beautiful countryside around the lake.
After that, we will take the bus again to cover the Lavaux vineyards road, classified like one of the most beautiful place of this world by the Unesco, to reach the village of Epaisse.
Recent Photos of this Tour
Schedule details
Select a month to view a calendar of availability and departure details.
Pricing information
Click the link below to check pricing & availability on your preferred travel date. Our pricing is constantly updated to ensure you always receive the lowest price possible.
Pricing information
Gruyeres and the famous Golden Express (from Geneva)
- Transport by air-conditioned coach
- Chocolate factory visit with tasting
- Cheese Diary visit with tasting
- Train ride on the Panoramic Golden Express
- Wine and grape juice tasting on a restaurant terrace
- Food and drinks, unless specified
- Hotel pickup and drop off
- Confirmation will be received at time of booking
Traveler Reviews
Reviewed by: Rosemary D, July 2015
A really fantastic tour, our tour guide was excellent, not too many people which was also great and overall a wonderful experience. I would highly recommend this tour.
Reviewed by: Nancy S, June 2015
our trip was lovely we really enjoyed ourselves every moment in the Golden Panoramic Express Train was
enjoyable and worth travelling


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Cheaper gas lowers measure of US consumer prices
Over the past 12 months, however, inflation-adjusted hourly earnings dipped 0.1 percent.
Without more jobs or higher pay, consumers could be forced to cut back on spending later this year. Consumer spending is critical because it accounts for 70 percent of economic activity
A small amount of inflation can be good for the economy. It encourages businesses and consumers to spend and invest money sooner rather than later, before inflation erodes its value.
The economy is growing but at a sluggish pace. That is keeping a lid on price increases. Slow growth makes it harder for consumers and businesses to pay higher costs. The economy expanded at just a 1.9 percent annual rate in the January-March quarter.
The Associated Press


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But he blamed his meltdown on the torrent of online abuse he received in the wake of his controversial appearance on Celebrity Big Brother.
The Blue singer was handed a £3,325 fine and banned from the roads for two years for failing to provide a specimen and causing £120 of criminal damage.
Ealing Magistrates' Court, in west London, heard the 30-year-old singer had been out partying to celebrate his best friend and bandmate Duncan James's birthday on the night of his arrest.
Officers spotted Ryan swerving erratically at 5.30am on April 11 as he drove his female friend's Audi A3 on the Uxbridge Road in Ealing.
There was an empty bottle in a pocket by the driver's seat and he stank of alcohol.
Majit Mahal, prosecuting, said: "Asked if he had consumed some alcohol that night, Mr Ryan said 'Yes, a few'.
"Officers then noticed that there was an empty bottle in the pocket of the driver's seat." He was in such a "drunken state" that officers took him straight to the police station.
But he refused to take a breath test and in a cell at Acton police station he urinated and was sick all over the floor.


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By the way Chris, I ended up using your icons (with an extra fat tv added) to throw together a cleaner version of CleatsandCode's CSS media query tool at www.woodcuttr.com.
If any of you use it, let me know if you spot any bugs or want any modern devices added to the tool.
More Branden Silva
keyboard shortcuts: ← previous shot → next shot L or F like Z toggle zoom


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Recently installed a GoPro mount on my truck and decided to do some high speed runs in a local parking lot
Traxxas 3s lipo 6400mAh
22p/50s gearing
After about 5 minutes of back to back runs, it made a cogging noise and just quit in the middle of the lot
Tried turning the ESC on and off, but got nothing
Tried switching back and forth from Lipo to NiMH mode, but didn't get the usual ascending and descending tones (lights work, but no sound)
Took a whiff and it definitely smelled burnt
Didn't have the ESC cooling fan plugged in, but both the ESC and motor were cool to the touch after the run (37* out today, so no fan needed)
Pretty sure it's toast, but I'll break out the meter and check for sure tomorrow.
Still converting the video footage, but I'll have it up later tonight.
Anyone have a link to the Lifetime Electronics Warranty form?
The one on the main site doesn't work for me


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Free Shipping On All BUNDLES and Orders over $199!
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"The shipping was excellent, driver was very courteous, and there was no damage to the packages. The keyboard was received in time for us to use in a wedding and 20 shows in the next few weeks. If we need any other equipment, the purchase will be made from you. Thanks for all your help." - Genny, GA
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Exclusively at Kraft Music... Our Roland GR-D V-Guitar Distortion Pedal BONUS PAK is a basic package designed to get you started with your new stomp box. You'll receive all of the following in this exclusive Kraft Music PAK:
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We are not able to ship any orders outside of the US and its territories.
***IMPORTANT NOTE: Please test your item before getting it fully assembled. For example, with digital pianos, unpack the keyboard portion, power it on and test all the keys. It is very rare that these items arrive with defects, but it is still a good idea to test it before spending time getting it fully assembled. Use caution when unpacking your purchase from its box, as some needed parts and pieces may be packed in and amongst the packing material. Be sure to save the carton and all packing materials, in case of a needed return. Do not write on the box and do not discard!
Boss Consumer Limited Warranty: Boss Corporation U.S. warrants that this product will be free from defects in materials for 5 (five) years, and labor for 2 (two) years. Click here for details.


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YIELD: Makes 4 Servings
Make dipping sauce:
Whisk all ingredients in small bowl to blend. (Can be prepared 1 day ahead. Cover and refrigerate.)
Make chicken:
Whisk eggs, soy sauce and sesame oil in large bowl to blend. Add chicken to egg mixture, turning to coat. Cover; chill at least 2 hours or overnight.
Heat vegetable oil in heavy large pot over medium-high heat to 375°F. Mix flour, ground ginger, salt and pepper in another bowl. Add chicken thighs and drumsticks to flour mixture; turn to coat.
Add fresh ginger to oil. Fry chicken thighs and drumsticks in hot oil until golden and cooked through, about 10 minutes per side. Using tongs, transfer chicken to paper towels; drain. Coat chicken breasts and wings with flour mixture. Fry until golden and cooked through, about 6 minutes per side. Transfer to paper towels. (Can be made 2 hours ahead. Let stand at room temperature.) Serve with dipping sauce.


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Letter to the Editor: Election day approaches
Larry Lambert, Wichita Falls
Election day approaches
The League of Women Voters of Wichita Falls has published a Voters Guide for the May 11 Municipal election. City positions at stake are Councilor's At-Large, District 1, and District 2. We will begin distribution by this weekend, a week prior to the start of early voting on Monday, April 29th.
Distribution sites include: Wichita Falls Public Library, Luby's Cafeteria, MLK Center, Times Record News, KFDX-TV3, KAUZ-TV6, First National Bank, American National Bank, (and City Hall until early voting starts). On the Internet, the Voters Guide is available at www.lwvtexas.org/local/wichitafalls. It may be read, downloaded, printed, or forwarded.
The League is a nonpartisan nonprofit organization, which works to promote political responsibility through active informed participation of all citizens in their government. The League does not support nor oppose any political party or candidate. It does publish factual information to help prepare citizens to cast an informed vote.
Subscribe to the Times Record News
Need Help? Call us at 1-877-710-6181.
Monday-Friday: 5:30am-8pm / Saturday: 6am-1pm / Sunday: 6am-1pm


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Created: 07/21/2014 1:37 PM WHEC.com
By: Associated Press
A college friend of Boston Marathon bombing suspect Dzhokhar Tsarnaev has been convicted of impeding the investigation into the attack.
Azamat Tazhayakov was found guilty Monday of obstruction of justice and conspiracy. Prosecutors say he agreed with a friend who removed Tsarnaev's backpack from his dorm room several days after the 2013 bombing. The backpack contained altered fireworks.
Tazhayakov's lawyers argued that the other friend removed the items from the dorm room at the University of Massachusetts-Dartmouth and then threw them away.
Prosecutors told the jury that both men shared in the decision to get rid of the items to protect Tsarnaev. The friend, Dias Kadyrbayev, faces a separate trial in September.
News10NBC/WHEC-TV welcomes your opinion and interaction on our website, but please remember to keep it clean. If you're advertising for another business, being profane, vulgar or slanderous your post will be deleted. By commenting on this website, you agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Use. Comments are not pre-screened before they posted.


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Stories Tagged "water rights"
Displaying 1 to 6 of 6 results.
19th Century Water Rights Examined in Drought Stricken California
posted on May 30, 2014 at 4:53 PM
Full Story
Court Sides With Oklahoma In Red River Dispute
posted on June 14, 2013 at 3:06 PM
The case concerns a dispute over access to southeastern Oklahoma tributaries of the Red River that separates Oklahoma and Texas. Full Story
Colorado River water report released in Vegas
posted on December 14, 2012 at 5:14 PM
Water administrators and state officials from western states have been considering a range of outside-the-box ideas such as piping water from the nation's heartland and towing Arctic icebergs south. Full Story
New Kansas water program has about 750 enrollees
posted on December 14, 2012 at 5:08 PM
The new program will allow irrigators to use more water during drought years and manage their water rights over five years. Full Story
California, Federal Officials Reveal Water Tunnel Plan
posted on July 27, 2012 at 1:55 PM
SACRAMENTO, Calif. (AP) - California and federal officials have announced plans for a massive twin tunnel system to carry water from the Sacramento-San Joaquin River Delta to farmland and cities. Gov. Jerry Brown and Interior Secretary Ken Salazar... Full Story
Giant Water Agency Approves Rate Hikes in Southern California
posted on April 13, 2012 at 3:36 PM
SAN DIEGO, California (AP) - The website displays a clock counting down seconds to Tuesday's board meeting of Southern California's major water wholesaler. It is part of a new front in California's water wars... Full Story
Displaying 1 to 6 of 6 results.


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Cazenovia How people cope with emotional issues at their jobs will be the topic of the next Cazenovia Forum lecture.
Author Anne Kreamer will discuss her latest book, "It's Always Personal: Emotion in the New Workplace," at 7 p.m. on Friday, May 4, in Cazenovia College's Catherine Cummings Theatre on Lincklaen Street.
The event is free of charge and no reservations are required. A reception will follow the talk.
To research her book, Kreamer spent two years travelling around the country speaking with experts and working Americans about the feelings and emotions that people experience at their jobs.
"I made a lot of discoveries, such as the fact that a lot more men cry on the job than you'd think, saleswomen make more money during the ovulation phase of their cycles and the cultivation of positive emotions isn't some Pollyanna myth but a scientifically proven tool to better health and problem solving," Kreamer said. "Indeed, the more of your authentic emotional self you bring to work [the] happier and more effective you will be."
Kreamer is also the author of the book, "Going Gray: What I Learned About Beauty, Sex, Work, Motherhood, Authenticity and Everything Else That Really Matters," which she developed from a feature she did for "More" magazine about the process, when she was 49, of letting her hair grow out to show her natural gray. In it, she skillfully uses the experience to explore thoughts about aging and femininity.
Her upcoming book, "Plan C," is about the unprecedented professional adaptability required of everyone in the 21st century.
Kreamer has worked as a columnist for "Fast Company" and "Martha Stewart Living," and is a frequent blogger on HBR.org.
Previously, she was executive vice president and worldwide creative director for the television channels Nickelodeon and Nick at Nite.
She holds a degree from Harvard College and lives in Brooklyn with her husband and two daughters.
The Cazenovia Forum is a not-for-profit organization established in 2006 by community members focused on promoting the understanding and discussion of national and international issues.
By organizing and underwriting lecture events featuring nationally-known experts, the group intends to further Cazenovia's commitment to knowledge-seeking and community involvement.
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