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Publications (224)1815.2 Total impact
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ABSTRACT: Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting. Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations. While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors. This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.Biomarkers in Medicine 05/2015; DOI:10.2217/bmm.15.31 · 2.86 Impact Factor
Article: Electrical remodeling reflected by QRS and T vector changes following cardiac resynchronization therapy is related to survival in heart failure patients with left bundle branch block[Show abstract] [Hide abstract]
ABSTRACT: We investigated changes in electrocardiographic spatial QRS and T vectors as markers of electrical remodeling before and after cardiac resynchronization therapy (CRT) and their association with altered outcome. In 41 patients with LBBB, ECGpost was recorded during intrinsic rhythm after interrupting CRT pacing and compared to the pre-implant ECGpre and the ECG during CRT (ECGCRT). Mean spatial angles between QRS and T vectors were determined with the Kors matrix conversion. Left ventricular ejection fraction (LVEF) was determined with nuclear isotope ventriculography before CRT implantation (LVEFpre) and at inclusion (LVEFpost). Following CRT, LVEF improved significantly from 26±10 to 36±14% (p=0.01). Duration of QRSpre (168±15ms) was not different from QRSpost (166±15ms). A smaller angle between QRSCRT and Tpost was related to a greater angle between Tpre and Tpost (Pearson's R -0.61 - p<0.001). During follow-up (30±2months) 9 patients (22%) died. Univariate Cox regression revealed higher mortality in the patients with lower LVEFpost (HR 1.10, p=0.01), a larger angle QRSCRTTpost (HR 1.03, p=0.03), a smaller angle QRSpreQRSpost (HR 0.97, p=0.03) and smaller angle TpreTpost (HR 0.95, p<0.01). After adjusting for LVEFpost, only smaller angle TpreTpost was associated with mortality (HR 0.96, p=0.03). Electrical remodeling can be quantified by measuring the angles between spatial QRS and T vectors before, during and after CRT. In absence of QRS duration changes, more extensive electrical remodeling is associated with a significantly better survival. QRS and T vector changes deserve further investigation to better understand the individual response to CRT. Copyright © 2015. Published by Elsevier Inc.Journal of Electrocardiology 02/2015; DOI:10.1016/j.jelectrocard.2015.02.004 · 1.36 Impact Factor
Article: Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in Patients with Acute Myocardial Infarction Based on Individual Patient Data.[Show abstract] [Hide abstract]
ABSTRACT: Rationale: The ACCRUE (Meta-Analysis of Cell-based CaRdiac stUdiEs) is the first prospectively declared collaborative multinational database including individual data of patients (IPD) with ischemic heart disease treated with cell therapy. Objective: We analyzed the safety and efficacy of intracoronary cell therapy after acute myocardial infarction (AMI) including IPDs from 12 randomized trials (ASTAMI, Aalst, BOOST, BONAMI, CADUCEUS, FINCELL, REGENT, REPAIR-AMI, SCAMI, SWISS-AMI, TIME, LATE-TIME; n=1252). Methods and Results: The primary endpoint was freedom from combined major adverse cardiac and cerebrovascular events (MACCE; including all-cause death, re-AMI, stroke, and target vessel revascularization). The secondary endpoint was freedom from hard clinical endpoints (death, re-AMI, or stroke), assessed with random-effects meta-analyses and Cox regressions for interactions. Secondary efficacy endpoints included changes in end-diastolic volume (ΔEDV), end-systolic volume (ΔESV), and ejection fraction (ΔEF), analyzed with random-effects meta-analyses and analysis of covariance. We reported weighted mean differences between cell therapy and control groups. No effect of cell therapy on MACCE (14.0% vs. 16.3%, hazard ratio 0.86, 95%CI: 0.63;1.18) or death (1.4% vs 2.1%) or death/re-AMI/stroke (2.9% vs 4.7%) was identified in comparison to controls. No change in ΔEF (mean difference: 0.96%, 95%CI: -0.2;2.1), ΔEDV, or ΔESV was observed compared to controls. These results were not influenced by anterior AMI location, reduced baseline EF, or the use of MRI for assessing left ventricular parameters. Conclusions: This meta-analysis of IPD from randomized trials in patients with recent AMI revealed that intracoronary cell therapy provided no benefit, in terms of clinical events or changes in left ventricular function.Circulation Research 02/2015; DOI:10.1161/CIRCRESAHA.116.304346 · 11.09 Impact Factor
Article: Epicardial catheter-based ventricular reconstruction (ECVR) in a patient with ischemic heart failure and an anteroapical aneurysm[Show abstract] [Hide abstract]
ABSTRACT: Extended anterior myocardial infarction (MI) is frequently followed by left ventricular (LV) remodeling ensuing in heart failure and aneurysmatic transformation of the infarcted myocardial segment. Therapies that attenuate or reverse pathological LV remodeling have been shown to improve functional status and outcomes. This case reports our recent experience with a catheter based technique for ventricular restoration.11/2014; 70(2):2295333714Y0000000100. DOI:10.1179/2295333714Y.0000000100
Article: Impact of Alpha- and Beta-Adrenergic Receptor Blockers on Fractional Flow Reserve and Index of Microvascular Resistance.[Show abstract] [Hide abstract]
ABSTRACT: We investigated the effect of β- and α-adrenergic blockers on fractional flow reserve (FFR) and index of microvascular resistance (IMR). In 43 patients (pts) with intermediate stenoses, we measured FFR and IMR before and after nonselective β-blocker propranolol (30 μg/kg, n = 20) and selective β1-blocker metoprolol (40 μg/kg, n = 23) IC; (b) In additional 21 pts after percutaneous coronary intervention (PCI), FFR and IMR were measured before and after α-blocker phentolamine (3 mg) IC. Neither propranolol nor metoprolol changed values of FFR and IMR. Phentolamine slightly decreased FFR (from 0.88 ± 0.05 to 0.87 ± 0.06, p = 0.025) but did not change IMR. FFR decreased from >0.80 to ≤0.80 in 3 pts (14 %), but in none, the value decreased to <0.75. β-blockers do not affect FFR and IMR in intermediate stenoses. After PCI, a mild decrease in FFR occurs after α-blockers, though of limited clinical impact.Journal of Cardiovascular Translational Research 11/2014; DOI:10.1007/s12265-014-9599-8 · 2.69 Impact Factor
Article: Three-Dimensional Echocardiography-Derived Vena Contracta Area at Rest and Its Increase During Exercise Predicts Clinical Outcome in Mild-Moderate Functional Mitral Regurgitation[Show abstract] [Hide abstract]
ABSTRACT: Background:This study assessed the independent significance of color Doppler 3-D vena contracta area (VCA) at rest and during exercise as a predictor of clinical outcome in mild-moderate functional mitral regurgitation (FMR).Methods and Results:The subjects consisted of 62 patients (age, 68±11 years; 76% male) with chronic systolic heart failure and mild-moderate FMR (<2+/4) at rest. All patients underwent VCA assessment at rest and during semi-supine bicycle exercise. During median follow-up of 17 months (IQR, 13-20 months), 15 patients (24%) had composite endpoint of all-cause death (n=3), heart failure admission (n=11), and heart transplantation (n=1). At baseline, patients with vs. without endpoint had significantly larger VCA at rest (17±6 mm(2)vs. 13±7 mm(2), P=0.002) and at peak exercise (35±16 mm(2)vs. 21±12 mm(2), P<0.001). On Cox regression analysis, large (≥15-mm(2)) resting VCA (HR, 7.6; 95% CI: 1.93-13.02; P=0.004) and large (≥20-mm(2)) exercise-induced increase of VCA (HR, 5.1; 95% CI: 1.39-15.21; P=0.014) were independently associated with composite endpoint. Concomitant presence of large VCA at rest and its large increase during exercise occurred in 53% of patients with, vs. in only 8% without, endpoint (negative predictive value, 86%).Conclusions:The presence of relatively large VCA at rest and its significant increase during exercise is independently associated with adverse clinical outcome in patients with mild-moderate FMR at rest.Circulation Journal 10/2014; 78(11). DOI:10.1253/circj.CJ-14-0183 · 3.69 Impact Factor
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ABSTRACT: Background: The presence of ergoreflex activity and its current relationship to hyperventilation and prognosis in cardiac patients is unclear. Therefore, we evaluated ergoreflex activity in cardiac patients with and without heart failure (CHF) as well as in healthy subjects, and we examined how ergoreceptor activity was related to a mortality risk score in CHF (MAGGIC). Methods and Results: Twenty-five healthy subjects and 76 patients were included, among whom were 25 with ischemic heart disease (IHD), 24 with stable CHF, and 27 with unstable CHF. Ergoreflex activity was measured with a dynamic handgrip exercise, followed by post-handgrip regional circulatory occlusion (PH-RCO). Ergoreflex activity contributed significantly to ventilation (median [interquartile range] %V) in unstable CHF (81 [73-91] %V without PH-RCO, 92 [82-107] %V with PH-RCO, and 11 [6-20] difference in %V; P <.001) and was positively correlated with the MAGGIC risk score (Spearman p = 0.431; P = .002). No ergoreflex activity was observed in healthy subjects (-4 [-10 to 5] difference in %V), IHD (0 [-8 to 3] Diff in %V) and stable CHF (-3 [-11 to 6] difference in %V). Conclusions: Ergoreflex activity contributes to hyperventilation, but only in CHF patients with persistent symptoms, and is closely related to the MAGGIC risk score. Ergoreflex activity was not present in patients with IHD or stable CHIP, suggesting other reasons for the increased ventilatory drive in those patients.Journal of Cardiac Failure 07/2014; 20(10). DOI:10.1016/j.cardfail.2014.07.006 · 3.07 Impact Factor
Article: Percutaneous mitral valve repair in high-risk patients: initial experience with the Mitraclip system in Belgium.[Show abstract] [Hide abstract]
ABSTRACT: Treatment with percutaneous edge-to-edge mitral valve repair (Mitraclip) has recently been recommended as an alternative to conventional mitral valve repair for high surgical risk patients with symptomatic severe mitral regurgitation (MR). In this study, we report the first use of Mitraclip therapy in Belgium.
Article: α2A-Adrenergic Receptor Polymorphism Potentiates Platelet Reactivity in Patients With Stable Coronary Artery Disease Carrying the Cytochrome P450 2C19*2 Genetic Variant.[Show abstract] [Hide abstract]
ABSTRACT: Platelet α2A-adrenergic receptors (ARs) mediate platelet aggregation in response to sympathetic stimulation. The 6.3-kb variant of α2A-AR gene is associated with increased epinephrine-induced platelet aggregation in healthy volunteers. The cytochrome P450 2C19*2 (CYP2C19*2) loss-of-function allele influences P2Y12-mediated platelet inhibition and hence the rate of major adverse cardiovascular events. We assessed the influence of 6.3-kb α2A-AR gene variant on platelet aggregation and its interaction with CYP2C19*2 loss-of-function allele in patients with stable angina on aspirin and clopidogrel (dual antiplatelet therapy). Aggregation to 5 increasing doses of epinephrine (from 0.156 to 10 μmol/L) was assessed in aggregation units by Multiplate Analyzer and platelet reactivity in P2Y12 reactivity units and % inhibition by VerifyNow P2Y12 assay before percutaneous revascularization. Gene polymorphisms were analyzed with TaqMan Drug Metabolism assay. Of 141 patients, aggregation was higher in 6.3-kb carriers (n=52) when compared with wild types (n=89) at all epinephrine doses (P<0.05) apart from 10 μmol/L (P=0.077). Percentage inhibition was lower (P=0.048) in 6.3-kb α2A-AR carriers. Percentage inhibition was lower (P=0.005) and P2Y12 reactivity units was higher (P=0.012) in CYP2C19*2 allele carriers. Higher P2Y12 reactivity units (P=0.037) and lower percentage inhibition (P=0.009) were observed in carriers of both 6.3-kb α2A-AR variant and CYP2C19*2 allele when compared with wild-type or with either mutation on its own. The 6.3-kb α2A-AR variant is associated with increased platelet reactivity to epinephrine and has an additive effect along with CYP2C19*2 loss-of-function allele on P2Y12-mediated platelet responses in patients with stable angina on dual antiplatelet therapy.Arteriosclerosis Thrombosis and Vascular Biology 04/2014; 34(6). DOI:10.1161/ATVBAHA.114.303275 · 5.53 Impact Factor
Article: Advances in Induced Pluripotent Stem Cells, Genomics, Biomarkers, and Antiplatelet Therapy Highlights of the Year in JCTR 2013.[Show abstract] [Hide abstract]
ABSTRACT: The Journal provides the clinician and scientist with the latest advances in discovery research, emerging technologies, preclinical research design and testing, and clinical trials. We highlight advances in areas of induced pluripotent stem cells, genomics, biomarkers, multimodality imaging, and antiplatelet biology and therapy. The top publications are critically discussed and presented along with anatomical reviews and FDA insight to provide context.Journal of Cardiovascular Translational Research 03/2014; DOI:10.1007/s12265-014-9555-7 · 2.69 Impact Factor
Article: Evolving concepts of angiogram: fractional flow reserve discordances in 4000 coronary stenoses[Show abstract] [Hide abstract]
ABSTRACT: The present analysis addresses the potential clinical and physiologic significance of discordance in severity of coronary artery disease between the angiogram and fractional flow reserve (FFR) in a large and unselected patient population. Between September 1999 and December 2011, FFR and percent diameter stenosis (DS) as assessed by quantitative coronary angiography were obtained in 2986 patients (n = 4086 coronary stenoses), in whom at least one stenosis was of intermediate angiographic severity. Fractional flow reserve correlated slightly but significantly with DS [-0.38 (95% CI: -0.41; -0.36); P < 0.001]. The sensitivity, specificity, and diagnostic accuracy of a ≥50% DS for predicting FFR ≤ 0.80 were 61% (95% CI: 59; 63), 67% (95% CI: 65; 69), and 0.64 (95% CI: 0.56; 0.72), respectively. In different anatomical settings, sensitivity and specificity showed marked variations between 35 to 74% and 58 to 76%, respectively, resulting in a discordance in 35% of all cases for these thresholds. For an angiographic threshold of 70% DS, the diagnostic performance by the Youden's index decreased from 0.28 to 0.11 for the overall population. The data confirm that one-third of a large patient population shows discordance between angiogram ≥50%DS and FFR ≤0.8 thresholds of stenosis severity. Left main stenoses are often underestimated by the classical 50% DS cut-off compared with FFR. This discordance offers physiologic insights for future trials. It is hypothesized that the discordance between angiography and FFR is related to technical limitations, such as imprecise luminal border detection by angiography, as well as to physiologic factors, such as variable minimal microvascular resistance.European Heart Journal 03/2014; 35(40). DOI:10.1093/eurheartj/ehu094 · 14.72 Impact Factor
Article: Impact of the Preoperative Risk and the Type of Surgery on Exercise Capacity and Training After Valvular Surgery[Show abstract] [Hide abstract]
ABSTRACT: Information on exercise capacity and training in patients who underwent valvular surgery is scarce. The aim of this study is to evaluate postoperative exercise capacity and functional improvement after exercise training according to the preoperative risk and type of surgery. In this prospective study, 145 patients who underwent aortic valve surgery (AVS) or mitral valve surgery (MVS) and who were referred for cardiac rehabilitation were stratified according to the preoperative risk (European System for Cardiac Operative Risk Evaluation [EuroSCORE]) and type of surgery (sternotomy vs ministernotomy or port access). Exercise capacity was evaluated at the start and end of cardiac rehabilitation. Postoperative exercise capacity and the benefit from exercise training were compared between the groups. Patients with a higher preoperative risk had a worse postoperative exercise capacity, with a lower load, peak VO2, anaerobic threshold and 6-minute walking distance (all p <0.001), and a higher VE/VCO2 slope (p = 0.01). In MVS, port access patients performed significantly better at baseline (all p <0.05), but in AVS, ministernotomy patients performed better than sternotomy patients with a concomitant coronary artery bypass graft (p <0.05). Training resulted in an improvement in exercise capacity in each risk group and each type of surgery (all p <0.05). This gain in exercise capacity was comparable for the EuroSCORE risk groups and for the types of surgery, for patients after AVS or MVS. In conclusion, exercise capacity after cardiac surgery is related to the preoperative risk and the type of surgery. Despite these differences in postoperative exercise capacity, a similar benefit from exercise training is obtained, regardless of their preoperative risk or type of surgery.The American journal of cardiology 01/2014; 113(8). DOI:10.1016/j.amjcard.2014.01.413 · 3.43 Impact Factor
Article: Integration of remote monitoring of device diagnostic parameters into a multidisciplinary heart failure management programInternational journal of cardiology 01/2014; 172(3). DOI:10.1016/j.ijcard.2014.01.088 · 6.18 Impact Factor
Article: Response to letter regarding article, "efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation".Circulation 01/2014; 129(2):e21-2. DOI:10.1161/CIRCULATIONAHA.113.005709 · 14.95 Impact Factor
Article: Efficacy and Safety of Apixaban in Patients After Cardioversion for Atrial Fibrillation : Insights From the ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation)[Show abstract] [Hide abstract]
ABSTRACT: Objectives The aim of this study was to determine the risk of major clinical and thromboembolic events after cardioversion for atrial fibrillation in subjects treated with apixaban, an oral factor Xa inhibitor, compared with warfarin. Background In patients with atrial fibrillation, thromboembolic events may occur after cardioversion. This risk is lowered with vitamin K antagonists and dabigatran. Methods Using data from the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial, we conducted a post-hoc analysis of patients undergoing cardioversion. Results A total of 743 cardioversions were performed in 540 patients: 265 first cardioversions in patients assigned to apixaban and 275 in those assigned to warfarin. The mean time to the first cardioversion for patients assigned to warfarin and apixaban was 243 ± 231 days and 251 ± 248 days, respectively; 75% of the cardioversions occurred by 1 year. Baseline characteristics were similar between groups. In patients undergoing cardioversion, no stroke or systemic emboli occurred in the 30-day follow-up period. Myocardial infarction occurred in 1 patient (0.2%) receiving warfarin and 1 patient receiving apixaban (0.3%). Major bleeding occurred in 1 patient (0.2%) receiving warfarin and 1 patient receiving apixaban (0.3%). Death occurred in 2 patients (0.5%) receiving warfarin and 2 patients receiving apixaban (0.6%). Conclusions Major cardiovascular events after cardioversion of atrial fibrillation are rare and comparable between warfarin and apixaban. (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation [ARISTOTLE]; NCT00412984)Journal of the American College of Cardiology 01/2014; 63(11):1082–1087. · 15.34 Impact Factor
Article: The C-CURE Randomized Clinical Trial (Cardiopoietic stem Cell therapy in heart failURE) ReplyJournal of the American College of Cardiology 12/2013; 62(25):2454-6. DOI:10.1016/j.jacc.2013.09.014 · 15.34 Impact Factor
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ABSTRACT: Regenerative cell-based therapies are associated with limited myocardial retention of delivered stem cells. The objective of this study is to develop an endocardial delivery system for enhanced cell retention. Stem cell retention was simulated in silico using 1- and 3-dimensional models of tissue distortion and compliance associated with delivery. Needle designs, predicted to be optimal, were accordingly engineered using nitinol, a nickel and titanium alloy displaying shape memory and superelasticity. Biocompatibility was tested with human mesenchymal stem cells. Experimental validation was performed with species-matched cells directly delivered into Langendorff-perfused porcine hearts or administered percutaneously into the endocardium of infarcted pigs. Cell retention was quantified by flow cytometry and real-time quantitative polymerase chain reaction methodology. Models, computing optimal distribution of distortion calibrated to favor tissue compliance, predicted that a 75°-curved needle featuring small-to-large graded side holes would ensure the highest cell retention profile. In isolated hearts, the nitinol curved needle catheter (C-Cath) design ensured 3-fold superior stem cell retention compared with a standard needle. In the setting of chronic infarction, percutaneous delivery of stem cells with C-Cath yielded a 37.7±7.1% versus 10.0±2.8% retention achieved with a traditional needle without effect on biocompatibility or safety. Modeling-guided development of a nitinol-based curved needle delivery system with incremental side holes achieved enhanced myocardial stem cell retention.Circulation Cardiovascular Interventions 12/2013; 6(6). DOI:10.1161/CIRCINTERVENTIONS.112.000422 · 6.98 Impact Factor
Article: Monocyte-Platelets Aggregates as Cellular Biomarker of Endothelium-Dependent Coronary Vasomotor Dysfunction in Patients with Coronary Artery Disease.[Show abstract] [Hide abstract]
ABSTRACT: Monocyte-platelet aggregates (MPA) are increased in patients with acute coronary syndrome. We investigated whether MPA are associated with the presence of functionally significant coronary stenoses or with coronary arterial endothelial dysfunction. One hundred forty five patients undergoing elective coronary angiography were prospectively enrolled. Functional significance of coronary stenosis was assessed by fractional flow reserve (FFR). Thirty randomly selected patients underwent pacing protocol to evaluate Coronary endothelium-dependent vasomotor function (CVF). Whole blood was drawn to evaluate MPA. In patients with FFR ≤ 0.8 (FFRpos, n = 75), MPA did not significantly differ from FFR >0.8 patients (FFRneg, n = 70) (38.1 % [25.7-56.6] vs 34.0 % [20.5-49.9], p = 0.08). CVF was similar in FFRpos and FFRneg patients (percent vessel diameter change, %VDC = 7.19 % [6.01-10.9] vs 8.0 % [0.81-9.80], p = 0.78). Yet, patients with abnormal CVF showed higher MPA as compared to patients with preserved CVF (28.3 % [28.8-53.4] vs 20.5 % [17.0-32.9], p = 0.01). Moreover, MPA was inversely correlated with %VDC (R (2) = 0.26, p < 0.01). MPA levels are significantly higher in patients with abnormal coronary vasomotor function regardless of the presence of functionally significant coronary stenosis.Journal of Cardiovascular Translational Research 12/2013; DOI:10.1007/s12265-013-9520-x · 2.69 Impact Factor
Article: Safety and effectiveness of drug-eluting stents versus bare-metal stents in elderly patients with small coronary vessel disease[Show abstract] [Hide abstract]
ABSTRACT: Drug-eluting stents (DES) are more effective than bare-metal stents (BMS) in small coronary vessel disease. Whether this is true in elderly patients, it is unclear, as frailty and a high rate of comorbidities could increase the rate of DES-related complications. To assess procedural and long-term clinical outcomes of elderly patients with small vessel disease treated with DES or BMS. Consecutive elderly patients (≥ 75 years old) treated with stenting of native small coronary arteries (reference vessel diameter and implanted stent<3mm) were recruited during 2004-2008. Procedural and long-term clinical outcomes were compared between patients treated with BMS and DES. Propensity score-adjusted logistic regression analysis was performed to account for potential selection bias. Among 293 patients (175 BMS, 118 DES), peri-procedural myocardial infarction (12 [7%] vs. 5 [4%]; P=0.35) and blood transfusions (3 [2%] vs. 0; P=0.08) were not significantly different between the BMS and DES groups. Clinical follow-up (96% of patients, median [interquartile range] follow-up 3.5 [2.4] years) showed significantly lower adjusted major adverse cardiac events (hazard ratio [HR] 0.42, 95% confidence interval [CI] 0.24-0.72; P=0.002) and target vessel revascularization (TVR) (HR 0.33, 95% CI 0.14-0.76; P=0.009) in the DES group. No significant differences were observed between the groups in terms of death, myocardial infarction, stent thrombosis or bleeding. In this retrospective, non-randomized analysis of the treatment of small vessel disease in elderly patients, DES were as safe and more effective than BMS with a significant reduction in TVR.Archives of cardiovascular diseases 11/2013; 106(11). DOI:10.1016/j.acvd.2013.06.056 · 1.66 Impact Factor
Article: Efficacy and Safety of Apixaban in Patients Following Cardioversion for Atrial Fibrillation: Insights from the ARISTOTLE trial.[Show abstract] [Hide abstract]
ABSTRACT: To determine the risk of major clinical and thromboembolic events after cardioversion for atrial fibrillation in subjects treated with apixaban, an oral factor Xa inhibitor compared with warfarin. In patients with atrial fibrillation (AF), thromboembolic events may occur after cardioversion. This risk is lowered with vitamin K antagonists and dabigatran. Using data from ARISTOTLE, we conducted a post-hoc analysis of patients undergoing cardioversion. A total of 743 cardioversions in 540 patients were performed: 265 first cardioversions in patients assigned to apixaban and 275 in those receiving warfarin. The mean time to the first cardioversion for patients assigned to warfarin and apixaban was 243 + 231 and 251 + 248 days respectively; 75% of the cardioversions occurred by 1 year. Baseline characteristics were similar between groups. In patients undergoing cardioversion, no stroke or systemic emboli occurred in the 30 day follow-up period. MI occurred in 1 patient (0.2%) receiving warfarin and 1 receiving apixaban (0.3%). Major bleeding occurred in 1 patient (0.2%) receiving warfarin and 1 receiving apixaban (0.3%). Death occurred in 2 patients (0.5%) receiving warfarin and 2 patients receiving apixaban (0.6%). Major cardiovascular events after cardioversion of AF are rare and comparable between warfarin and apixaban.Journal of the American College of Cardiology 10/2013; 63(11). DOI:10.1016/j.jacc.2013.09.062 · 15.34 Impact Factor
Top Journals
OLV Ziekenhuis AalstAlost, Flemish, Belgium
Uppsala University
Uppsala, Uppsala, Sweden
- UCR-Uppsala Clinical Research center
University of Glasgow
Glasgow, SCT, United Kingdom
- Institute of Cardiovascular and Medical Sciences
Klinički centar SrbijeBeograd, Central Serbia, Serbia
Technische Universiteit EindhovenEindhoven, North Brabant, Netherlands
University Hospital of Lausanne
Lausanne, Vaud, Switzerland
- Service de cardiologie
Universitair Ziekenhuis GhentGand, Flemish, Belgium
Vrije Universiteit BrusselBruxelles, Brussels Capital, Belgium
Charles University in PraguePraha, Praha, Czech Republic
Cardiovascular Research FoundationNew York, New York, United States
University of LeicesterLeiscester, England, United Kingdom
University College LondonLondinium, England, United Kingdom
University of Naples Federico IINapoli, Campania, Italy
Ghent UniversityGand, Flemish, Belgium
Harvard UniversityCambridge, Massachusetts, United States
Catharina HospitalEindhoven, North Brabant, Netherlands
Beth Israel Deaconess Medical Center
Boston, MA, United States
- Department of Medicine
Harvard Medical School
Boston, Massachusetts, United States
- Department of Medicine
Detská fakultná nemocnica s poliklinikou v BratislavePresburg, Bratislavský, Slovakia


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For NBA, courting Steve Ballmer could be a strategic move
Dan Gorenstein
May 30, 2014 Getting one of the world's richest people to replace Donald Sterling is a big win for the NBA.
NBC buys Olympics rights for Alibaba's treasure
David Gura
May 7, 2014 Comcast will pay a reported $7.65 billion.
If Clippers are for sale, what's the franchise worth?
Sally Herships
Apr 30, 2014 Clippers are suddenly hot, but what are they worth as a franchise?
Sizing up Donald Sterling's other business interests
Nancy Marshall-Genzer
Apr 30, 2014 Donald Sterling's said to be worth almost $2 billion,most in real estate holdings.
Donald Sterling donates a lot of Clippers tickets
Shea Huffman
Apr 30, 2014 The notoriously cheap owner of the Clippers is a big donor. Of Clippers tickets.
Adam Silver, NBA will try to force Clippers' sale
Kai Ryssdal
Interview by
Apr 29, 2014 But no matter what happens, owner Donald Sterling will likely walk away with money in his pocket.
Clippers owner Donald Sterling suspended, fined
Noel King
Apr 29, 2014 Why Donald Sterling matters to the NBA: Franchisee-owners are in charge.
What if you found out your boss made racist remarks?
Lindsay Foster Thomas
Apr 28, 2014 The NBA is investigating the legitimacy of a recording said to be of the owner of the Los Angeles Clippers.
What can the NBA do about unwanted owners?
David Brancaccio
Apr 28, 2014 We look at why breast-cancer survivors have a high rate of long-term unemployment. And, a look at the markets in the week ahead.
Russia may have overspent for the Olympics
Stephen Beard
Feb 24, 2014 Sochi locals wonder what will happen to the hotels and facilities that were built.


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Originator:Peter Collingsworth
Submitter:Martin Joergensen


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Francisco Liriano took another step toward proving that his dismantling at Coors Field two weeks ago was a fluke. He carved up the San Diego Padres with a devastating slider, forcing swing after swing at...Read More
I don't know about you but I'm always pulling for the underdog. I had a guy named Ramon Foster on... Read More ↔
Re-Tooling The NFL Draft Sometimes the strangest things go on in my head when thinking of things to write about... Read More ↔
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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
33 year old man | Loretto, MN, USA | Seeking women 25-35 within 30 miles
A day of worry is more exhausting than a day of work.
I'm making this profile, but still not sure about this internet dating stuff. I'm from a small town, and don't have a lot of time to get to new places. On the other hand that's exactly what i would like to do, find somewhere or something new and exciting to check out. I'm looking for someone to enjoy the small things with, and have some fun doing it, willing to try new things and be themselves. I am extremely laid back, sometimes people think i'm mad or too serious, but that's just me, calm and relaxed. I love to be outdoors, hiking, on the water, or just exploring some new city. I'm sort of a country boy, enjoy the classic styles of Johnny Cash, Haggard, and David Allen Cole. Currently I mostly listen to anything Eric Church. Saw his concert by the way, AMAZING! I'm gonna keep this short, so if your interested shoot me an email, oh, and sorry about the pics i'm not a huge picture person these were the best I could come up with.
Dining out , Fishing/Hunting , Music and concerts , Exploring new areas , Playing cards , Playing sports , Travel/Sightseeing , Watching sports
Baseball, Football, Golf
I exercise 5 or more times per week.
Don't display my sign
I like Dogs
I had three dogs, two labs, and a husky, but the ex took them.
Middle of the Road
I enjoy Duluth, the boundary waters. Would love to make it up to ely, MN soon. I enjoy the ocean, Lived in CA for a year, hated living there, but would go visit again.
University of Wisconsin–Stout, Menomonie, WI
I enjoy a lot of different music, but I stick mostly to country.My favorite artists are Eric Church, Johnny Cash, and Meryle Haggard. I like almost any food, I specifically enjoy spicy. I like to get inot a good TV series, the most recent was Suits
I really enjoy hiking, anything outdoors. Love to enjoy a sporting event, Vikings, Twins, Wild, you name it. I like to fish and hunt, wish I would get out more to do it. Love to try new restaurants, or any new Food.
Enjoy a John Grisham, or Dean Koontz novel.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|6'2" (187cms)
|5'5" (165cms) to 5'10" (177cms)
|Body type:
|Athletic and toned
|Slender, Athletic and toned
|No preference
|No preference
|I'll tell you later
|No preference
|No preference
|Labor / Construction
|No preference
I work for a small Concrete company based out of Waconia, MN. I also am co-owner of a small bar and bowling alley also in Waconia.
|$35,001 to $50,000
|No preference
|Never Married
|No preference
|Have kids:
|No preference
|Wants kids:
|White / Caucasian
|No preference
|Christian / Other
|No preference
|Some college
|No preference


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Surnames Mcdwoen to Mceahern Free Family Genealogy
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Diamond Queen Slot
Diamond Queen slot
was relatively quick making the transition from land-based to online and the version above is pretty much identical in all respects to the one I've played at casinos in London. There are a couple of differences in that the stacked Diamond Queen symbols don't appear in the base game and the animations in the feature are a bit drab but otherwise, same game and in fact, the online version probably has a higher RTP (theoretical return) too.
The thing about this game is that it is very high variance. Compared to
playing Cleopatra
or the
classic tumbling reels game Davinci Diamonds
you can go for really long periods with not a lot happening which can be frustrating but what you are playing for is the free spion feature which introduces wild reels. You only get 3 free spins but each one adds another entirely wild reel to the equation. The third spin is usually the most lucrative as you would expect but it can also be a dud.
I generally prefer high risk games and there are quite a few games of that ilk now on
Online Casinos Vegas
but this one has never really grabbed me. Where other higher variance games like
IGT's Cleopatra 2
or one of my all-time favourite games,
the Great Blue slot by Playtech
keep you more interested with more regular features or stacked wilds, you are only playing Diamond Queen to get the free spin feature and even then, only the 3rd spin does anything worthwhile generally.
One thing I have started to notice more and more in the land-based casinos round here is that the lower variance games that used to dominate, games like
the Wolf Run slot
, Enchanted Unicorn and Cleopatra are getting replaced gradually with more volatile games, including Diamond Queen. To be fair, some are getting a bit long in the tooth now and the new multi-slot kiosks give more options but it is definitely a trend, perhaps inspired by Novomatic's Gaminator machines which have some very volatile games on them like the
very popular Book Of Ra
. Or maybe it's coincidence, who knows.
Please note that IGT slot games are blocked in some countries including the USA and Australia meaning the play for fun option on Diamond Queen probably won't work either - for now.
Diamond Queen Slot
/ 5 based on
player ratings
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Weekend night time security/noise patrol
A vacancy has suddenly arisen for the following role. THE JOB: To drive around all our larger holiday let houses in central Brighton to check there are no parties taking place, check that all is in order and there is no excessive noise. A company
- Permanent


text:
Get an extra 40% off most items at Catherine's using the coupon code above. New arrivals are 30% off with this coupon. Shipping is $7.95 on any size order or you can have your order shipped for Free to your local Catherine's store.
Catherine's offers classic career and casual clothing for plus-size women at affordable prices. Coupon will apply to clearance items. Some brands restricted. See site for details.


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This just in: people in Colorado are smoking weed WHILE they ski and snowboard. And not only is this illegal, it's just plain dangerous! Inside Edition uses hidden cameras, prodding interviews and other investigative techniques to get to the bottom of this crisis.
Update: Thanks to this lovely report, one of the shacks featured has been dismantled. Nice one, dudes.
admin one of the founders of the internet.
Email this author | All posts by admin


text:
Not for Rodriguez the decorous, red-carpet likes of Gwynnie, Sandra Bullock, or Tom Cruise, but "hot criminal" Jeremy Meeks.
A decorous group of nine panelists presented their positions one at a time, following distinctly un-Israeli rules of etiquette.
1660s, from Latin decorus "becoming, seemly, fitting, proper," from decus (genitive decoris) "ornament" (see decorate). Related: Decorously; decorousness.


text:
Join Website or existing users Login
Join Club Website TSSAA Eurosport Scoreboard NCAA Eligibility Center Dobyns-Bennett HS Website
The Big 7 Conference Jamboree will take place at Indian Highland Park on Tuesday, August 11th. View News Item »
Girls Soccer schedule for 2015. View News Item »
This list highlights the major summer events for the 2015 Lady Indian soccer team. View News Item »
Indian Highland Park parking lot will be closed, beginning Monday, May 18th. View News Item »
Team/Individual Camp will be held July 19-23. View News Item »


text:
NYC Garment District Clergy and Judicial Robe Supplier to Participate in 'NYC Makers - The MAD Biennial', 7/1
New York, NY
Historic New York City Garment District clothier Duffy and Quinn/Craft Robe Company manufacturers of church robes, judicial apparel and school uniforms invited to participate in the prestigious Museum of Arts and Design exhibition July 1 - Oct 12. This exhibition - NYC Makers: The MAD Biennial, will spotlight creative communities thriving across the five boroughs of New York City today. This is first exhibition of its kind and will showcase the work of 100 highly inventive designers, artists & artisans whose contributions have left a lasting impression upon all that New York City is.
The garment district of New York City has a long colorful history and Duffy and Quinn/Craft Robe Company's Marvin Goldman (now in his mid-80s), his father and his grandfather helped shape that history. According to Marvin Goldman, "My grandfather came over from Poland and set up a fabric business in the garment district in the mid-1890s, and then my father expanded his father's business and became a clothier, cutting out suits from bolts of fabrics. I took over the business from my father in the mid-1950s which is when we began to specialize in clergy and judicial apparel as well as attire for choir, confirmation, school uniforms and graduation ceremonies. "
The inclusion in this exhibition of Marvin Goldman's 118 year old family business from New York Cities' famed garment district, exemplifies the thrust of the Museum's exhibition to highlight the interconnected web of cultural production in the New York City today and underscore the importance of craft in contemporary life.
About Duffy and Quinn/Craft Robe Company:
One of the oldest and most colorful family owned apparel manufacture and suppliers in the United States, the roots of Duffy and Quinn/Craft Robe Company began in New York City's garment district in the mid-1890s. Marvin Goldman's grandfather imported bolts of fabrics that were used across the garment district. Later Marvin's father took over the business, as Marvin recalls "cutting out suits from these great rolls of fabric." Marvin took over the business from his father in the mid-1950s specializing in clergy and judicial apparel as well as attire for choir, confirmation, school uniforms and graduation ceremonies that are supplied to individuals and institutions across the United States.
Duffy and Quinn/Craft Robe Company is still located in New York City's garment district as it has been for the past 118 years.
About Author
- Casting Roundup: Sarah Chalke, Kim Raver Headline New Pilots
- ADVENTURE TIME Headed to the Big Screen?
- Pilot Season Roundup: Colm Feore, Daniel Stern, Dave Annable to Star in New Shows
- James Franco to Star in New Fox Comedy, WHY HIM?
- Christopher Meloni to Star in WGN America's Slave Drama UNDERGROUND
- Check Out Alex Dunphy's Full College Essay from Latest MODERN FAMILY Episode
- Photo Flash: HBO Reveals Key Art for GAME OF THRONES Season 5
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- CONSTELLATIONS' Jake Gyllenhaal and Ruth Wilson Set for THEATER TALK This Weekend


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Grainger Industrial Supply (1874 Products)
Address: 1151 E. Columbia Ave. Branch 441, Riverside, CA
Business Type: Distributor
Description: Grainger helps customers save time and money by providing them the right products to keep their facilities up and running. Grainger's customers are 2.0 million businesses and institutions in 157 countries. While each customer has a unique facility to operate and a different problem to solve, our... (more)
Des Pac Equipment Cases
Address: 6750 Peralta Place, Riverside, CA
Business Type: Manufacturer


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Kirk Douglas was one of the 29 rabbits recently surrendered at a Bay area animal shelter. He was a sleek, exotically colored boy who died suddenly following surgery.
Though he was only with us a very short time, we are deeply saddened by his death. He was a gentle sweet soul who was on the brink of seeing life in a whole new , kind, compassionate way, rather than his past life of neglect.
Rest in peace our special little boy.
This beautiful handcrafted vase is beige with terra cotta brown and cream colored accents in a swirling pattern. Vase has a matte finish. Would make a beautiful accent piece for any home, and would be perfect for displaying dried flowers, or branches of the season. Vase is signed by the artist on the base. Each piece is unique and slight variations in size, glaze and smoothness is part of the beauty of artisan pieces. Artist wished to remain anonymous.


text:
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text:
Sequoyah Council, 713
Boy Scouts of America
Johnson City, Tennessee
Support Scouting
National Youth
Leadership Training
Scout Night at
Smokies Stadium
Friends of Scouting
Golf Scramble
Provisional Camp Program
College of Commissioner Science
Summer / Fall
Race Tickets
ArrowTour Coming
To Camp Davy Crockett
Camp Ranger
Position Open
National Youth Leadership Training
Scouts First Class & age 13 by July 12,2015
Any Registered Venturing Youth
July 12 - 17, 2015
Camp Davy Crockett
142 Boy Scout Road
Whitesburg, TN 37891
More Information
2nd Annual
Friends of Scouting Golf Scramble
Benefiting the Sequoyah Council – Boy Scouts of America
Friday, May 29, 2015
Registration – 8-8:45am - - Shotgun Start – 9am
Competition Format
Competition will be a 4-man scramble format.
Mulligan packages will be available for $10/player the day of the event and will include a mulligan, red tee and toss.
More Information
Camp Davy Crockett Provisional Camper Program
No Troop……..No Problem!
There is no reason for you to miss out on all the fun just because your troop isn't going to summer camp, or because other summer plans mean you won't be able to go to camp with your troop. You may even want to do an additional week of camp, just because you had such a great time. Scouts who wish to go to camp can attend as part of the Camp Davy Crockett Provisional Camper Program.
Provisional Camping is just like camping with your home troop, except you'll have the opportunity to camp with new friends, as you join scouts from all over the council and beyond. You'll meet new people and have the opportunity to develop friendships that can last a lifetime. Provisional Scouts will join a selected troop attending camp with an experienced leader. We will make sure you have a safe and fun camp experience. Provisional scouts can participate in all of the camp's exciting programs, including advancement, competitions, and patrol events. It's a great way finish additional Merit Badges, or to try out a new part of the program that you weren't able to try before.
Sign Up Now
If you would like to attend Camp Davy Crockett as a Provisional Scout, simply fill out the Provisional Scout Application form and return it with your initial payment to:
Sequoyah Council, BSA
PO Box 3010
Johnson City, TN 37602
Provisional Application
CDC Parent's Guide
2015 College of Commissioner Science
PACCS is held annually around the last weekend of May or first weekend in June at Ridgecrest Conference Center in Black Mountain, North Carolina. The 2015 College will be held the weekend of June 5th through June 7th, 2015.
2015 Information / Registration
Bristol Motor Speedway is offering Tickets for:
Ford Thunder Valley National Drag Qualifying
Food City 300
Irwin Tools 500
More Information
The Order of the Arrow is turning 100 in 2015, and we're bringing the celebration to Camp Davy Crockett on June 25, 2015 from 3:00PM - 10:00 PM. All Scouts, volunteers, and alumni are welcome to join us as we host #ArrowTour, the OA's national centennial experience.
Find out more here
Camp Ranger Position Open
The Sequoyah Council is now accepting applications for the position of Camp Ranger at Camp Davy Crockett. Send resume to Ronald Cameron, Program Director, PO Box 3010, Johnson City, TN 37602 or e-mail to Ronald Cameron.
MBU Log-in
To Contact us:
Office Address
Sequoyah Council, BSA
PO Box 3010
Johnson City, TN 37602
Phone: 423-952-6961
Fax: 423-952-6960
Copyright © 2015 Sequoyah Council, BSA


text:
PNoy not prematurely campaigning – Palace
MANILA, Philippines – Presidential Spokesperson Edwin Lacierda said President Benigno Aquino is not engaged in premature campaigning despite endorsing TESDA chief Joel Villanueva and Aurora Rep. Juan Edgardo Angara on Sunday.
Lacierda said he does not consider this as premature campaigning because the period for the filing of certificates of candidacy has not yet started.
Lacierda said the President is just proud of the accomplishments of these personalities.
Meantime, Lacierda said that the President will make a good endorser. "No doubt about that," he said.
In a recent Pulse Asia survey, Vice President Jejomar Binay emerged as the top endorser for the 2013 senatorial elections.
Seventy-three percent of the respondents said they would vote for the candidates endorsed by Binay, who will run come 2016.
Two-thirds or 66% said they would vote for Aquino's endorsed candidates.


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Local Boy Scouts teamed up with the Bullitt County Woman's Club to do some landscaping at the Bullitt County Detention Center on Saturday, June 6.
Scouts from Shepherdsville Boy Scout Troop 868 and Cub Scout Pack 868 turned out early Saturday morning to construct four flower beds at the front of the jail.
A landscaping plan had been prepared by the Bullitt County Woman's Club in consultation with the local Master Gardener Association and the Bullitt County Extension Office.
The Woman's Club purchased most of the needed plants and mulch. Scouts provided the manpower needed to take the project from paper to reality. Troop 868 donated bedding plants and some additional mulch to complete the project.
An advance team of scouts tilled the soil on Friday so that planting could begin without delay on Saturday morning.
Because of this, little time was wasted on Saturday and the entire project was completed in about 3 hours.
Community Service has long been a hallmark of the Boy Scouting program. Troop 868 and Pack 868 are proud to call Shepherdsville home. Both units welcome new members any time of the year.
Cub Scouting is for boys in elementary grades 1 through 5 (ages 6~10). Pack 868 meets at the Shepherdsville Community Center on Thursday evenings from August through May and hosts several summertime events during the months of June and July. Contact Cubmaster Steven Frank at 922-0025 or visit the Pack's website at www.cubpack868.com for information about joining. Boys who have completed Kindergarten and will be entering first grade in the fall can join now.
Boy Scouting is for boys in middle and high school (ages 11-17). Troop 868 is one of the most active units in the entire Lincoln Heritage Council. The troop meets at the Community Center every Tuesday evening year round. Contact Scoutmaster Bob Meek at 964-5270 or visit www.troop868.com for more information.
Boy Scouts from Troop 868 worked the soil for a landscaping project at the Bullitt County Detention Center.
Troop 868 Boy Scouts Gabe DiEnno, Dalton Hay, and Dylan Kallin and Pack 868 Cub Scout Kenneth Frank spread mulch in one of the new flower beds at the Bullitt County Detention Center
Boy Scouts from Troop 868 planted a shrub as part of a landscaping project at the Bullitt County Detention Center.
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Ross Cimpl
Head Football Coach
University of Sioux Falls '07
University of Sioux Falls '10
Recruiting Territory: Southeast South Dakota
Since taking over the Dakota Wesleyan University football team, Ross Cimpl has guided the Tigers to three straight winning seasons. Cimpl is 21-14 overall in three season, including an 8-3 record in 2013. In his third season, the Tigers were ranked No. 20 in the preseason poll and remained in the rankings for most of the campaign. The team finished 7-4 overall and 4-4 in the GPAC. Cimpl coached the Tigers to 13 All-GPAC honors in 2014, while picking up six total GPAC Player-of-the-Week awards. The 2014 senior class tied the school record for most wins by one group at 27 over the last four years. Under Cimpl, senior running back Francois Barnaud broke the school career rushing record in 2014.
Cimpl has coached 42 All-GPAC honorees, including nine First Team and 11 Second Team members. There have been two NAIA All-Americans, three Beyond Sports Network All-Americans, 10 Daktronics/NAIA Scholar Athletes and one CoSIDA Academic All-American at DWU under Cimpl. Following the 2013 season, Cimpl was named the GPAC Coach-of-the-Year and the AFCA Region 4 Coach-of-the-Year.
Before coming to Dakota Wesleyan, Cimpl spent three years as an assistant coach at USF while pursuing a master's degree in business administration, which he received in February 2010. He coached everything from the defensive backs to the special teams to tight ends, wide receivers and running backs. Cimpl was a part of the Cougars' NAIA national titles in 2008 and 2009 and their runner-up finish in 2007. He helped the Cougars to a 42-1 record from 2007 to 2009. Sioux Falls won three straight GPAC titles in those years. From 2002 to 2006, Cimpl was a member of the Cougar football team. He was a team captain in 2005 and 2006, a member of the 2006 national championship team and was named the team's Special Teams Player-of-the-Year in 2005. Cimpl was on the dean's list at USF and earned Academic All-American honors in 2005.
Cimpl lives in Mitchell with his wife, Linda. The couple has two sons, Preston and Porter, and a daughter, Charlee.
Zach Parks
Offensive Coordinator
University of Montana Western '12
Recruiting Territory:
Zach Parks enters his first season as the offensive coordinator/offensive line coach with the DWU football team in 2015. He takes over an offense that has set records over the last several seasons in terms of passing and rushing yardage.
Prior to joining the Tigers, Parks was the run game coordinator at the University of Jamestown in Jamestown, N.D., where he helped guide the Jimmies to a 5-5 record in 2014. Jamestown ranked sixth in the nation in total offensive yards per game in 2014 with 288.6. From 2008-2012, Parks coached at his alma mater, Montana Western. He served as the team's offensive line coach from 2009-2011 and the defensive line coach in 2012.
Parks played college football at Modesto Junior College and Montana Western after graduating from Turlock High School in 2004. Graduated from Montana Western with a degree in history in 2012.
Parks now resides in Mitchell.
Jason Glasco
Assistant Coach/Linebackers Special Teams Coordinator Recruiting Coordinator
University of Sioux Falls '07
Dakota Wesleyan University '12
Recruiting Territory: Nebraska
Jason Glasco enters his fifth season as a part of the Tiger football coaching staff. His first two seasons were spent as a graduate assistant, and he will continue to work with the team's linebackers and serve as both the special teams and recruiting coordinator as an assistant coach in 2015. Glasco has coached 12 All-GPAC linebackers, including Brady Bonte,who was nominated for the prestigious Cliff Harris Award, given to the top small college defense player of the year in the NAIA. Glasco came to Dakota Wesleyan University after two seasons as an assistant coach at the University of Sioux Falls. While with the Cougars, he worked with the team's defensive backs. Glasco joined the coaching ranks after a successful playing career at Sioux Falls. He was a three-year starter at safety and a two-time All-GPAC Honorable Mention pick. He earned All-GPAC First-Team honors and All-America Honorable Mention honors once. Glasco, who graduated with a Bachelor of Science degree in exercise science in 2007, played for the Cougars from 2003 to 2006 and was a part of the 2006 national championship team. Glasco grew up in Sioux Falls and attended Sioux Falls Roosevelt High School. Glasco received his master's degree in educational policy and administration from Dakota Wesleyan in 2012.
Houston Jones
Assistant Coach/Wide Receivers Academic Coordinator
Iowa State University '09
Recruiting Territory: Southwest Minnesota
Houston Jones enters his second season as an assistant coach for the Tiger football team in 2014. Jones will work with the team's wide receivers and quarterbacks. In 2013, Jones worked with senior receiver Anthony Muilenburg, who set the school record for receibing yards in a game (251) and finished the year ninth in the NAIA in receiving yards (1,002). The Oklahoma City, Okla., native graduated in 2009 from Iowa State University with a degree in social sciences after a four-year career with the Cyclones' football team. He recorded 33 receptions for 390 yards in his career, and finished third on the team with 32 catches for 384 yards as a junior in 2008. After graduation, Jones returned to Oklahoma City where he coached football at Western Heights High School and Northeast Academy, his alma mater. In his prep career at Northeast, Jones threw for 4,073 yards and ran for 1,321 more and was an all-state selection.
Brian Rose
Graduate Assistant Coach/Defensive Line Video Coordinator
University of Northern Iowa '12
Recruiting Territory: Northeast South Dakota
Brian Rose enters his first season as a graduate assistant coach for the Tiger football team in 2014. He will work with the defensive line. Rose, a Springville, Iowa, native, played college football at Iowa Central Community College in Fort Dodge, Iowa. He played two seasons at Iowa Central before transferring to the University of Northern Iowa, where he graduated in May 2012 with a degree in education. Following graduation, Rose taught social studied and coached football at River Valley Community Schools in Correctionville, Iowa. He served as the offensive and defensive lines coach and special teams coordinator, and helped River Valley make the state playoffs two years in a row. Under his direction, River Valley led the district in nearly all special teams categories. Following his graduation from Springville High School, Rose enlisted in the US Marine Corps Reserves and served his country while pursuing his education. As U.S. Marine Corporal of the 2nd Battalion, 24th Marines he was activated to Iraq's complex and dynamic Al Anbar province in support of Operation Iraqi Freedom where he served in a leadership role as a Team Leader and Squad Leader for 2/24 Echo Company. Rose earned all-conference academic honors and was named an all-district offensive lineman and the team's defensive MVP at Springville High School. Rose is pursuing his master's degree in education policy and administration.
Chase Kuhlman
Graduate Assistant/Running Backs Coach
University of South Dakota '12
Kuhlman joins Cimpl's coaching staff as a graduate assistant and running backs coach in 2015. He will look to help DWU continue its recent run of success on the ground after the graduation of the school's all-time leading rusher,Francois Barnaud.
Kuhlman, a Wagner, S.D., native, comes to DWU from the University of South Dakota where he graduated in 2012 with a degree in math eduacation. Kuhlman did not play football in college, but was a two-time all-conference performer at Wagner High School where he graduated in 2008.
He is enrolled at DWU and working on a Master's degree in education policy and administration. He now resides in Mitchell.


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"Writing Rebellion presents a methodologically rich approach to Loyalist writings that have fallen through the cracks of national literary histories. Much more than a recovery effort, Gould's important book reveals the dynamic relation between literary forms and Revolutionary conflict and shows how Loyalist aesthetics continue to resonate in liberal political theory." Sandra Gustafson, author of Imagining Deliberative Democracy in the Early American Republic
"Writing the Rebellion refocuses attention on the losers of the American Revolutionand on the experience of loss itself. Gould's Loyalists dissented from critical categories we now invoke to evaluate American political literature. Severing virtue from politics, suspicious of the seductions of language, Loyalists did not believe there was an American 'public' in revolutionary America. By carefully recovering their intellectual world, Gould gives us a timely reminder of the history of a divided country." Eric Slauter, author of The State as a Work of Art: The Cultural Origins of the Constitution
"Philip Gould provocatively asks how the literary history of the Revolution changes when we take Loyalists out of their marginal role as Hollywood bad guys and resituate them in the history of political writing in British America. . . . . Writing the Rebellion leaves us with a vision of eighteenth-century print culture in British America as more labile and more literary than we'd realized, and with an expanded sense of why that matters." Early American Literature


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Cotton On Sales Assistant Interview Questions
Interview Experience
Interview Experience
Getting an Interview
Getting an Interview
Interview Difficulty
Interviews for Top Jobs at Cotton On
- Christmas Casual (14)
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3 Candidate Interview Reviews Back to all InterviewsSort: Popular Date Difficulty
Sales Assistant Interview
interviewed at Cotton On (Melbourne (Australia)) in January 2012.
took way too long. two 3 hour group interviews. lots of people
Interview Questions
- role plays Answer Question
Other Interview Reviews for Cotton On
Sales Assistant InterviewAccepted OfferNeutral ExperienceEasy Interview
I applied online. The process took 4+ weeks – interviewed at Cotton On (Perth, Western Australia (Australia)) in June 2011.
Online application, sent an email confirming you for group interview, have group interview where they ask you questions/give you scenarios and what would you do, make you watch a video about their company 'values' then given phone call like a week later saying if you have the job or not.
Interview Questions
- What does customer service mean to you? 1 Answer
Was first offered a job at a location too far away so had to go for another group interview and then was offered a job at a location way closer so i accepted.
Sales Assistant InterviewAccepted OfferPositive ExperienceEasy Interview
I applied online. The process took 2 weeks – interviewed at Cotton On in December 2010.
Applied online, a couple of hours later i recieved a phone call asking whether i would like to attend an interview, obviously i accepted. Then a mini interview occured asking how many hours i could work, whether any holidays were booked in the near future. When i arrived the interview was a group interview where i was asked to 'sell' the person next to me after 5 minutes of talking to them. Also we were asked 'fun' questions like your celebrity crush. and then asked the basic interview question 'why you' all spoken infront of the group. a week later i was offered a posistion, after checking my references, which i acepted. i was then invited to a group phase where all the employed from the interviews were introduced to the company.
Interview Questions


text: Tucked down and alley the Tib was the result of a Trip Advisor search. We were delighted with the atmosphere – old fashioned in an increasingly brash city. The staff give the impression they revere the place – and with justification. The seating was quickly rearranged for five – never the... read more


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Bobbi Brown Skin Foundation SPF 15
456 reviews
62% would repurchase
Package Quality: 4.3
Price: $$$$
Package Quality: 4.3
Price: $$$$
INGREDIENTSSkin Foundation SPF 15 – (Active ingredients: Octinoxate 7.50% and Titanium Dioxide 1.00%) Water, Methyl Trimethicone, Neopentyl Glycol Diethylhexanoate, Isononyl Isononanoate, Glycerin, Pentylene Glycol, Lauryl PEG-9 Polydimethylsiloxyethyl dimethicone, HDI/Trimethylol Hexyllactone Crosspolymer, Talc, Boron Nitride, Disteardimonium Hectorite, Stearic Acid, Palmitic Acid, Dimethicone, Lecithin, Aluminum Dimyristate, Tocopherol, Myristic Acid, Silica, Magnesim Ascorbyl Phosphate, Sodium Chloride, Sodium Citrate, Sorbic Acid, Chlorphenesin, Phenoxyethanol. May contain: Titanium Dioxide (CI 77891), Iron Oxides (CI 77491, CI 77492, CI 77499).
on 3/4/2013 1:12:00 AM
Age: 19-24
Skin: Combination, Olive, Not Sure
Hair: Black, Wavy, Medium
Eyes: Brown
This foundation is for people with very little blemishes or other skin problems. I have been using the product for 3 weeks now and because the shade matches me perfectly. For reference I am an NC40 and I use 4.5 Warm Natural. The formula is very thin and watery, which is probably good for normal skin types. For my oily skin, the product just slides off and never really absorbs. You can tell there's foundation sitting on top of my skin. Now, I have tried this with and without a primer, on top of moisturizer and without. And I get the same effect on my oily skin. I like that this foundation doesn't have that weird medicinal smell the other Bobbi Brown foundations have (I think Lavender oil is added, I could be wrong). Overall, for the price I paid, I would not repurchase because it doesn't provide the coverage and finish I want.
on 3/1/2013 9:54:00 AM
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Brunette, Straight, Fine
Eyes: Blue
This is a great foundation and one i always go back to! I would say that i prefer to use it in the summer months and as a day time foundation as i like a fuller coverage for nights out but it glides on the skin beautifully and looks so natural. I use beige/warm beige and will definitely be purchasing it again.
on 3/1/2013 3:12:00 AM
Age: 36-43
Skin: Dry, Fair-Medium, Not Sure
Hair: Blond, Other, Other
Eyes: Green
The problem with this is easy: it just does not last and looks horrible, very different from when it is freshy applied, hours later. That is my only but large complaint.
on 2/12/2013 9:45:00 AM
Age: 18 & Under
Skin: Dry, Tan, Warm
Hair: Brown, Straight, Fine
Eyes: Brown
So after wearing heavy MAC foundation for a long time, i started to get really sick of the patchy, and unnatural texture it left on my skin. Mac foundation is good if youre looking for FULL COVERAGE, but since i dont have any pimples or acne, i only need light- medium coverage to cover up my patchy and uneven skin. Bobbi brown does a perfect job in doing so. When you squeeze a pump of bobbi brown and mac on your hand, you can already feel the difference in weight, which is what you are feeling on your face. Bobbi brown is amazingly light on the skin, making it feel natural and basically feels like a second SKIN!
This is what ive been looking for, something that doesnt feel heavy and look cakey. Just a natural Dewy finish. I have dry skin, and this foundation doesnt make my face feel tight, or dried out at the end of the day.
The only con i have to say about this product is its lasting power. I'd say it will last you for a good 4 hours, until some parts start rubbing. If you use a primer and set it with some powder, it should last you up to 6 hours. Not a full day advantage, which is why im still searching for my HG foundation. Other than the staying power, bobbi brown covers everything possible that i would want.
NOTE: I am an NC40 in MAC, and colour 4.5 - warm honey in Bobbi Brown. During winter i am an NC37 which is colour number 4. Bobbi brown has yellow undertones, which are best for Tan and olive undertoned skin. If you find it difficult finding a foundation that matches warm undertones, you are missing out if you havent yet discovered Bobbi
! Highly reccomended! and Will keep repurchasing until i find my HG! this is the closest ive found so far.
on 2/11/2013 7:08:00 PM
Age: 19-24
Skin: Normal, Fair, Not Sure
Hair: Brunette, Wavy, Medium
Eyes: Hazel
I love this foundation, I haven't found anything like it. The color selection is the best part about it. Great natural finish. Just purchased my second tube, I really have never found anything as true to my fair neutral complexion.
on 2/8/2013 10:04:00 PM
Age: 25-29
Skin: Dry, Fair-Medium, Not Sure
Hair: Black, Straight, Fine
Eyes: Brown
Great foundation if you have dry skin. It's definitely moisturizing and leaves a natural finish if you have dry skin, and a dewy glow if you have normal-to-oily skin. If you have REALLY oily skin, I think it's going to make you have a shiny face. No break outs or irritation from this. The formula is very nice to the skin and the SPF 15 is always a plus!
For reference, I am NC 25 in MAC, asian, yellow undertones, and I used #2.5 in Warm Beige.
on 2/8/2013 9:51:00 AM
Age: 19-24
Skin: Other, Other, Not Sure
Hair: Other, Other, Other
Eyes: Other
This foundation is light on my skin and has good coverage. I have sensitive skin and this foundation does not irritate it. I have used mineral powders in the past and found that they dry out my skin. I am very happy with this foundation and will continue to use it.
on 2/5/2013 6:30:00 PM
Age: 19-24
Skin: Combination, Fair, Neutral
Hair: Black, Straight, Fine
Eyes: Brown
Great foundation! It covers the skin imperfections flawlessly and it looks like I'm not wearing any foundation at all. Provides a light-medium coverage and it's buildable. Best used with a primer if you are in out in the humid weather all day (especially in Singapore) as it tends to 'disappear' within a few hours (4-5 hours) without a primer. When I'm in the UK where it is drier, especially during the winter months, the foundation lasts all day (from 9am - 9pm) with just minor touch-ups on my nose (it gets oily throughout the day. I just blot the oil away with a piece of tissue and touch up with the compact powder). The pump dispenses the product perfectly - you can control how much product you want. A little goes a long way with this foundation. It's selling for around SGD79 in Singapore so I tend to buy it at Heathrow Airport where it is sold at GBP27 (if I remember correctly). A cheaper alternative to my Chanel Vitalumiere Aqua foundation which I use during summer when I'm more tanned as it is a darker shade. This foundation lasts for a very long time! I like how it comes with SPF too cause I'm too lazy to use an additional sunscreen. Makes me feel a little better knowing that I have some sun protection on.
on 1/30/2013 4:05:00 PM
Age: 25-29
Skin: Sensitive, Fair, Warm
Hair: Brown, Straight, Medium
Eyes: Hazel
This foundation was perfect in almost every way. I liked the watery consistency, and it covered just the right amount. However, the Porcelain was too dark, and the Alabaster too light! It's a pity, as all the Bobbi Brown foundation are much too yellow based for my skin tone, apart from the Alabaster in this line. If only it were a tiny bit darker.
on 1/29/2013 3:16:00 PM
Age: 18 & Under
Skin: Sensitive, Fair, Neutral
Hair: Red, Wavy, Other
Eyes: Blue
I don't wear foundation on a regular basis. I've really been trying to let my skin breathe lately, but when I do need some coverage, I go straight to my Bobbi Brown Foundation. It's light enough but covers up any redness, and works well with my combination skin type. I also like how it has SPF in it, but doesn't wash me out. If I use it, I usually have to wear a setting powder with it, or it can get a little oily around my forehead. Otherwise, a great foundation!
Popular Liquid Foundations


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Christ is Risen! Truly He is Risen!
The Feast of the Resurrection (Easter) is celebrated on April 12, 2015. Following Easter, we will be in the Holy 50 days of Resurrection, leading up to the Feast of Pentecost. How do the Holy 50 days differ from other times in the year? Learn more about this joyful season here.


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Why is the output of
sqrt not an integer for "16" in PHP?
php > $fig = 16;
php > $sq = sqrt($fig); //should be 4
php > echo $sq;
php > echo is_int($sq); // should give 1, but gives false
php >
I feel that the problem is in the internal presentation which PHP hides similarly as Python. How can you then know when the given figure is integer after taking a square root?
So how can you differentiate between
4 and
4.12323 in PHP without using a regex?


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My Girl Pixie Allen from http://redpixiesfantasyart.blogspot.com and I have a great group named CREATIVES on Facebook. We have a bunch of challenges—-COLOR ONES-4 COLOR CHALLENGES-GRAPHITE PENCIL DRAWINGS and a great group of people! I hope you will come check us out! For now I will post my 4 color project. Its a background but I […]Go to post page
January 30th, 2012 by kellyd


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This is what strawberries were made for. Yum.
"This smoothie is so bright, cheerful, and delicious, it's like a blast of sunshine on even the rainiest days!" – MOTTSBELA
Yes, it's delicious. Yes, it's green. Yep, it's a spinach smoothie. Give it a try!
Recipe of the Day
Apple Banana Smoothie
Thick and healthy fruit drink with apple, banana and orange juice. The frozen banana takes the place of shaved ice and results in a smooth, creamy texture. Serve with dollop of whipped cream for added effect.
Jim Wohlgemuth
Similar Recipes | More Daily Recipes
Sneak some fresh greens into your kids with this tasty smoothie.
Smoothie Collections7
Banana Smoothies
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Staff Picks
A Very Intense Fruit Smoothie
Berry Delicious
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Pineapple and Banana Smoothie
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Purple Monstrosity Fruit Smoothie
Strawberry Oatmeal Breakfast Smoothie
All-Around Good Smoothie
Groovy Green Smoothie
Peanut Butter and Banana Smoothie
Orange Glorious I
Peanut Butter Banana Smoothie
Mango Lassi II
Iced Mocha Fusion Shake
Banana Smoothie I
Gloomy Day Smoothie
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Triple Threat Fruit Smoothie
Groovie Smoothie
Kale and Banana Smoothie
Mongolian Strawberry-Orange Juice Smoothie
Orange Smoothie
Heavenly Blueberry Smoothie
Delicious Healthy Strawberry Shake
French toast is such a perfect breakfast, light lunch, or even supper on these warm days.
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Dessert or nutritious snack, you can't beat smoothies made with Dannon Yogurt.
Watch how to make a healthy yogurt and strawberry smoothie in your blender.
See how to brew the perfect cup of black, green, or herbal tea.


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I need to restart apache on a dozen servers. I can log into each one and do it or I can have one script on the first one do it for me. Can you help me out?
Server 1 has access to all the other servers through known hosts.
Manually I can run this:
ssh user@server2
service httpd restart
ssh user@server100
service httpd restart
How can I script this to run from server 1 to restart all my servers?


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
33 year old woman | Decatur, GA, USA | Seeking men 29-35 within 25 miles
Looking for brain dead zombie to go on boring dates with
I would like to meet someone who knows how to be a man, who knows how to be a good friend and companion, who is a healthy mix of creative and concrete. Someone I can trust to support, challenge and encourage me, and who can graciously accept the same from me. I come from a wonderful family with parents who are still happily married, so hopefully that will bode well for me. Things I love: My incredible family, My awesome dog, Nature, Outdoor activities, Yoga, Acroyoga, Aerial silks, Cooking delicious healthy food, Eating delicious healthy food, King of Pops, Gardening, Swing dancing, Creating art, Theme parties, Audiobooks, Wine, Chocolate, Long walks on the beach (what profile wouldn't be complete without those?) Things I cheerfully tolerate: Corny jokes, Drivers who accelerate a second after the light turns green, People with differing viewpoints, Hippies, Old people who tell the same stories over and over and over. Deal breakers: Smoking, Egocentrism, Most "-isms", Irresponsibility, Lack of Integrity.
Camping , Coffee and conversation , Cooking , Dining out , Gardening/Landscaping , Hobbies and crafts , Museums and art , Music and concerts , Exploring new areas , Performing arts , Playing cards , Religion/Spiritual , Shopping/Antiques , Travel/Sightseeing , Volunteering , Wine tasting
Cycling, Dancing, Other types of exercise, Running, Walking / Hiking, Yoga
I exercise 3-4 times per week.
I have Dogs
Bigger than a min pin, smaller than a doberman, faster than a speeding bullet, and just right for cuddling. You can find a picture of Gracie in my photos.
Middle of the Road
Locally: I'm partial to places I can walk/bike to: Yogurt Tap, Java Monkey, Twains, Form Yoga; Candler and Inman Parks, West Midtown, Land of a Thousand Hills Farther: Northern Cal, Italy, Asheville, anywhere in the Rockies
University of Georgia, Athens, GA
Music: most anything laid back and happy. TV: Ain't nobody got time for that! Food: try to follow Michael Pollan's advice, "Eat food, not too much, mostly plants."
Practicing and performing aerial silks-especially in a tree, pretty much anything that gets me outdoors-hiking, camping, bonfires, gardening, cooking, and (recently) honing my ice cream making skills.
Usually it's audiobooks in my car. Currently working through the Game of Thrones series.......very.......very......slowly.
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|What she is looking for
|5'6" (167cms)
|5'10" (177cms) to 6'4" (193cms)
|Body type:
|Athletic and toned
|About average, Athletic and toned
|No preference
|No preference
|No Way
|No Way
|Social Drinker, Moderately
|Medical / Dental / Veterinary / Fitness
|No preference
|I'll tell you later
|No preference
|Never Married
|Never Married
|Have kids:
|Wants kids:
|Definitely, Someday
|White / Caucasian
|White / Caucasian
|Christian / Other
|Christian / Protestant, Spiritual but not religious, Christian / Other
I was raised in a strong Christian home, and identify with a lot of Christian morals and values. However, I don't claim to have all the answers and enjoy gleaning wisdom from a variety of sources.
|Graduate degree
|Bachelors degree, Graduate degree, PhD / Post Doctoral


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Directed by archivist Andy Lanset, the department provides a central repository for thousands of audio recordings, photographs, memorabilia, reports, news items, program guides, institutional records, and promotional materials.
Among its holdings are more than 50,000 recordings in a variety of formats, from early lacquer and acetate discs, to reel-to-reel tapes, to digital audio tapes and compact discs.
Recently in Archives and Preservation
Utah Phillips, Will Rogers, and Tall Tales of America's First Radio Broadcast
Tuesday, October 23, 2012
The 'Anatomy' of Fannie Hurst, Memoirist and Romance Novelist
Monday, October 22, 2012
Largely forgotten today, Fannie Hurst was for many years one of the most highly paid and widely read novelists of her time. Anatomy of Me is Hurst's just-published autobiography, which she discusses at this 1958 Books and Authors Luncheon.
Dr Kranich, your piano's ready. I'm afraid it's not built by your dad.
Friday, October 19, 2012
On March 5, 1853 a German piano maker named Henry Steinway (né Steinweg) founded Steinway & Sons at 85 Varick Street in New York City, barely five blocks from the present-day WNYC studios. Less than three months later another, much younger German piano maker named Helmuth Kranich would also arrive at these shores. Little did he suspect that one of his children would someday work at a competing form of entertainment: radio, specifically WNYC.
A Hero, Removed: A. E. Hotchner on Hemingway's Role as "Emissary of Other Men's Dreams"
Friday, October 19, 2012
A.E. Hotchner, a friend of Ernest Hemingway during the last 14 years of the writer's life, reminisces about their relationship in this Books and Authors Luncheon appearance promoting his memoir, Papa Hemingway (1966).
The Political Playwright Rolf Hochhuth Assails the Catholic Church for 'Immoral Inaction'
Wednesday, October 17, 2012
Chaos rules at this rowdy 1964 meeting of the Overseas Press Club. The guest panel includes Catholic Church critic, Rolf Hochhuth, and a Catholic Church official.
The Civic Wit of Humorist Harry Hershfield
Monday, October 15, 2012
"New York City Mayors I Have Known" might be the better title for this 1954 installment of Campus Press Conference featuring guest Harry Hershfield -- columnist, cartoonist, and "Toastmaster Extraordinary."
Foreign Correspondent David Halberstam Analyzes Conflict in Vietnam
Friday, October 12, 2012
David Halberstam briefs this 1964 meeting of the Overseas Press Club on what he sees as a "sharp conflict" between America's official optimism and the reality experienced by reporters embedded in Vietnam.
John Gunther, Author of 'Inside' Travel Guides, Offers Glimpse of African Continent, 1955
Wednesday, October 10, 2012
Formerly a foreign war correspondent, Chicagoan John Gunther drew on his background to write the 'Inside' travel series, which included Inside Europe (1936), Inside Asia (1939), Inside Latin America (1941), and here, Inside Africa.
The Extemporaneous Sir Alec Guinness: Shorter Than You Thought, and to the Point
Monday, October 08, 2012
"The Actor and Clichés In the Theater," is the subject Sir Alec Guinness chooses for this impromptu 1964 performance before the Overseas Press Club.
Günter Grass on American Vagaries: Boxing, Dancing, and Creating Art
Friday, October 05, 2012
In May 1965, the Overseas Press Club hosted the German novelist Günter Grass, who had arrived in New York to teach a seminar at Columbia University.
Early Electronic Music on WNYC
Wednesday, October 03, 2012
In this 1974 episode of Musicale, Hubert S. Howe, Jr., selects a few original electronic music compositions synthesized at Queens College. Howe was one of the earliest progenitors of computer music.
The Benny Goodman Sextet Fields Requests on 'America in Swingtime'
Wednesday, October 03, 2012
This WNYC American Music Festival program from February 19, 1941 captures the Benny Goodman Sextet in a rare and wonderful moment.
We All Sag in the Middle: The Delightfully Indignant Edna Ferber
Monday, October 01, 2012
Popular best-sellers of the day, Edna Ferber's books also provided the stories for influential plays, musicals, and films. At this 1958 Books and Authors Luncheon, she talks about her new book, Ice Palace.
Feminine Mystique or Mistake: Men Make Fun of Women for Having Feelings, Then Dismiss Charges of Discrimination
Friday, September 28, 2012
"Is the Feminine Mystique a Mistake?" is the question posed at the beginning of this 1966 edition of Maincurrents, hosted by Lee Graham.
One Thousand Days: Salman Rushdie at Columbia, 1991
Thursday, September 27, 2012
On December 11, 1991, Salman Rushdie "quietly ventured outside Britain and emerged" [1] to speak at a Columbia University dinner celebrating the 200th anniversary of the First Amendment. The thunderous applause that greets Mr Rushdie's unexpected appearance sets the tone for his speech.
Cartoonist Jules Feiffer Probes the Intellectual Depth of Comics and Pop Culture, 1965
Wednesday, September 26, 2012
At a Books and Authors Luncheon featuring such literary establishment figures as the historian Arthur Schlesinger Jr. and the literary critic Alfred Kazin, a 36-year-old cartoonist gets up to speak.
'Most of Them Can Be Helped': Building a Language of Disability
Tuesday, September 25, 2012
These cerebral palsy radio spots, recorded in 1951 for the United Cerebral Palsy Fund, highlight the ideas and words applied to children born with disabilities.
James T. Farrell on a Writer's Inner Life
Monday, September 24, 2012
James T. Farrell, the creator of Studs Lonigan, is often thought of as a crude, dogged, naturalist writer; it's refreshing to hear the author speaking, in this recording from 1952, of what truly obsesses him: literature.
James L. Farmer Jr. Advocates Revolutionary Freedoms for African-Americans
Friday, September 21, 2012
"America is being forced to face itself," James Farmer proclaims in this 1963 Overseas Press Club appearance, before discussing the upcoming march on Washington and the historical roots of the civil rights struggle.
Abba Eban Pushes Israel's Application for U.N. Membership
Wednesday, September 19, 2012
In 1949, Israel's Abba Eban defends his country against a variety of accusations and urges the United Nations to act favorably on Israel's application for admission to that international body.


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Amazon Kindle Expands Publishing Platform
Policy Counsel
Senior Director of Federal Policy and the Washington Office
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The Kindle Digital Text Platform can now be used by self-service publishers outside of the U.S. to sell books in English, German, and French.


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Travel through the pristine wilderness of mystical Alaska
Adventure into the pristine wilderness of mystical Alaska. Be captivated by the unique flora and fauna of Denali National Park, trek out to glaciers and through forests and stare up in wonder at some of the tallest mountains in Northern America. Visit the bustling hub of Anchorage and explore the many delights of Juneau. This is a journey into pure wilderness, incredible landscapes and true natural beauty.
- Start
- Anchorage, United States
- Finish
- Juneau, United States
- Countries
- United States
- Themes
- Explorer, Wildlife
- Code
- Take a tour through the untouched wilderness of Denali National Park
- Choose to go whale-watching off the coast of Sitka
- Discover the secrets of Alaska's capital, Juneau
- See some of the US's highest peaks in Wrangell-St Elias National Park
- Explore the Alaska Native Heritage Center in Anchorage
- Look out for bears, wolves and caribou along the old Denali Highway
Day 1 Anchorage
Day 2-4 Denali National Park
Day 5 Alaska Range
Day 6-7 Wrangell-St Elias National Park
Day 8 Anchorage
Day 9-10 Juneau
Day 11 Sitka
Day 12-13 Juneau
TransportBus, Ferry, Plane, Private vehicle
AccommodationHotel (8 nights), Lodge (1 night), Motel (3 nights)
Included activities
- Denali National Park
- Scenic bus tour
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Important notes
2. Full passport details are required at time of booking.
Trip notes
Want an in-depth insight into this trip? Your trip notes provide a detailed itinerary, visa info, how to get to your hotel, what's included - pretty much everything you need to know about this adventure and more.View trip notes