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If you want to be a doctor when you grow up then this game gives you the perfect opportunity. Our cute adorable kids were playing and by mistake they had eaten something erroneous. Now they are suffering from food poisoning. Emma, Sophia, Allena and Ruby need a doctor immediately. Help those little ones be themselves when you give them first aid treatment. You can use different tools to check her, and then feed her water to make her puke and remove all the food from her stomach. After curing them, you can enjoy playing all 4 mini challenging games with those kids. Features include choose from four cute kids, tap to mix all fruits, tap to select different doctor tools, amazing realistic doctor game, enjoy playing 4 mini games, endless fun, 4 cute adorable kids, different realistic doctor tools, food to feed kids and 4 mini challenging games.
Are you a fan of candy games? Are you a fan of matching games? If the answer is yes, try Match 3 Candy Rush. Match 3 Candy Rush is a wildly addictive match three puzzle game! How to play: Tap on candy to match them and feel the rush. No time limit! No moves limit! So don't rush! Try to score as many points as possible! There are 6 different types of candy. But if you think it is easy to make a pair of three, Just try it. More difficult than ever. Match 3 Candy rush Features: Free to play! Hours of fun - Challenging courses - Endless scrolling game - Sweet and shining candies, so delicious! Easy and fun to play, but a challenge to fully master - Find big matches to create high score! Be warned: Insanely addictive Match 3 game - Exercise your fingers - Amazing graphics - Great music and sound effects - Endless pleasure. Once you start, you can't stop!
Ohhh, Kids have function at school and the kids need their dresses to be ready before party. Would you help those kids, and it's your chance to become a fashion designer? It's time to get busy & polish your sewing skills! Create & combine from lots of clothing designs, stitch, match, prints, patterns, and much more. The game is available with two different activities that is "stitch section" & "Studio Adventure". In stitch section you have to design & customize all costume & dresses! Pick your f
Physics based, very simple game. Connect 3 or more neighbours, same colored little figure to remove from playfield. Tap on the first figure and drag your finger on screen over to the figures. If you connect 4, you get points. If you connect 5 or more, you get points and extra time. if you remove the pinned figure, you get extra time. Watch your time, and don't reach the Limit line.
Rush as fast as you can. Dodge the oncoming hurdles. Help Little Santa, Little Smurfy, Dancy Deer Man to escape from angry Bull. The Santa Surfer Adventure game has Vivid and colourful HD graphics with different kinds of environments and ice land. The game is especially made for Christmas lovers with endless ice land running. Use the Monojet surfboard power to speed up the player with paint powered effect. The all new capcopter power to make player fly with gift box attraction effect. Different kinds of levels with endless map and ice land x-mas effects. Collect runtime gift bags to earn more gift boxes. Smooth movements with fast swipe acrobatics of players. Random objective achievements to boost up score multipliers.
Drive 50 plus officially licensed cars, from hot hatches to american muscle and 1000HP supercars. Buy your dream car, install performance upgrades and show your skills in 1/4 or 1/2 mile races. Challenge millions of players online: race 1 on 1, drive your opponent's car, or participate in real time 10 player races in Pro League. Lots of cars: Would you pick an iconic Skyline gtr, a classic 69' Mustang, or a brand new Bmw m3 as your ultimate driving machine? Do you dream about seeing 1000+ hp exotics pushed to the limit on a drag strip? This game includes virtually every sports car for you to enjoy. Umlimited depth: Do you think racing in a straight line is easy? Try to find the right balance between power and grip while staying in your class. Add nitrous oxide for more fun, but don't push the button too early. Go deeper and adjust gear ratios to shave off precious milliseconds. Think you can challenge a world record or win 10 tournaments in a row? Welcome aboard. Competitive multiplayer: Racing on your own may be fun enough, but the ultimate challenge is in the Online section. Go head to head against your friends or random racers, beat them while driving their own cars, or race against 9 players at once in real time competition. Join a team to exchange tunes, discuss strategy and share your achievements.
Welcome to the battle of birds, solve mindblowing fight puzzle of the birds. Welcome to the battle field of birds, solve the mindblowing fight puzzle of the birds. You have to shot the naughty birds in a way that they kill others automatically. Scratch your mind twice before shooting at any bird because you have limited shots in each level. Get cherished with all 30 levels, each time you will discover a new battle field to fight with birds.
Not another endless running and jumping game. Play the level mode and let us know do you feel the same about Caper. You love endless running arcade and action games. Not a problem try Run for life game mode. Jump and shoot like in contra and mario. Time your run and jump right to win the level in this easy action and arcade platform game and make a high score. The game is fun, simple and free. Offline game - Play without internet.
Subway Runner is super cool running game where you have to run as fast as you can while dodging the incoming aliens and zombies and jump right over them. Collect the coins and gems to score more. Don't forget to collect shield for extra protection! Run as far as you can to prove you're the best! Download free now and enjoy this never seen before game on your mobile phone
Travel the most beautiful candy world, experiencing cutest candy car racing , taste the sweetest candies, ice cream, chocolates, challenge the most impressive racing levels. Hot racing game is on, jump on your sweet candy car, join us in this racing fever! Let's go!
The Bank is guarded by a sleepy officer.Time to see how many gold pieces you can rob from the bank in 60 seconds.Get this free game and compete for the online highscore.You can even connect with your Facebook friends and see who is the best robber in your Facebook list.Note Facebook connection is optionalThis App is sponsored by advertisements.Get your FREE copy today.
Beauty wiped clean, like an eraser to wipe the screen can appear as massive beauty, once rubbed fill. Up to hundreds of beautiful women wearing sexy gorgeous coat look at you, just gently slide your finger, beautiful clothes you can be a little off, and finally be able to see you most want to see the beauty! Single lonely if you are looking for a new kind of entertainment - quickly download and install play it ~ really cool feeling!
strategy games mobile game war games popular running game army games driving games online shooting games


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Thursday, July 2, 2015
June, 2015
Junior Achievement Golf Day
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October 10, 2014 - Junior Achievement seeks PT Administrative Asistannt
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subset: commoncrawl


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I'm surprised I haven't run into this before, or at least I forgot how I got it working.
I have a standard EE relationship field. In this case, I have a "Products" channel, and each product belongs to an entry in the "Designers" channel.
I quite obviously want a page to list all products for a single designer. My first attempt looked like this:
{exp:channel:entries channel="designers" url_title="{segment_3}" limit="1"}
{reverse_related_entries channel="products" limit="15"}
According to anecdotal evidence in the EE documentation, you can't paginate reverse related entries. So what's the solution? Is there a way to easily grab all the product entry IDs, given the
url_title of a designer? Or do I have to resort to using SQL?
Is there any way I could solve this using the Stash add-on?


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Attention horror fans! CT HorrorFest returns on July 18, 2015! The event is presented by Connecticut-based horror website Horror News Network, one of the top horror news and information sites on the web.
Come meet horror celebrities and shop horror themed vendors at The Matrix Conference Center in Danbury, CT.
Purchase tickets for the event here.
Please Note: Celebrity autograph prices vary and are at the discretion of the celebrity. CT HorrorFest does not control what celebrities may charge for autograph or photo opportunities.
GUESTS: (so far)
Please note that guest list can change due to guest cancellation or events beyond our control.
Doug Bradley
The year was 1987 and a young flimmaker named Clive Barker unleashed his debut film Hellraiser unto the world. Based on Barker's novella The Hellbound Heart, Hellraiser quickly took the horror world by storm and Pinhead (or Lead Cenobite, if you prefer) became one of the most beloved, and feared, monsters in all of filmland.
CT HorrorFest is proud to announce that the one and only Doug Bradley will be a feautured guest on July 18, 2015. To quote Clive Barker, "there could never be a Pinhead without Doug Bradley".
Films: Hellraisers 1-8, Nightbreed, Wrong Turn 5
Gunnar Hansen
In 1974, what many consider to be the scariest film ever made was released to audiences across the world. Billed as a true story and the "account of the tragedy which befell a group of five youths, in particular Sally Hardesty and her invalid brother, Franklin", The Texas Chainsaw Massacre shocked audiences with it's disturbing look at a sadistic Texas family and introduced the world to the character of Leatherface.
CT HorrorFest is proud to announce that the original Leatherface, Gunnar Hansen, will be a featured guest on July 18, 2015.
Films: The Texas Chainsaw Massacre, Hollywood Chainsaw Hookers, Texas Chainsaw 3D
Warrington Gillette
In 1981, the company that brought us the suprise hit Friday the 13th were busy trying to capitalize on that success. They knew that they wanted their new film to be a direct sequel, taking place five years after the first, but they needed someone to be the face of the new and older Jason Voorhees. A young actor who initially auditioned for the male lead role of Paul left such an impression on director Steve Miner that he knew that he had to utilize him in the film and so the next incarnation of Jason Voorhees was born.
CT HorrorFest is proud to announce Warrington Gillette as a featured guest on July 18th, 2015.
Films: Friday the 13th Part 2, Penny Dreadful, Time Walker
Mick Foley
While this legend may not have his roots in the horror genre, he has probably spilled more real blood in the ring than most of our cherished movie villains have spilled fake blood in the movies. With a storied wrestling career spanning four decades in the WWE, WCW, ECW, NWA and TNA, this hardcore legend and multi-time best-selling author is a world-wide fan favorite.
Aliases: Cactus Jack, Dude Love, Mankind, Saint Mick
CT HorrorFest is proud to announce Mick Foley as a featured guest on July 18th, 2015.
Films: Anamorph, Hellevator Man
Michael Jai White
As a young man first in Brooklyn, NY and then in Bridgeport, CT this guest began his mastering of eight different styles of martial arts. At the age of twelve he earned his first black belt and has since earned seven more. He graduated college and became a junior high school teacher while doing commerical and soap opera work on the side before moving to Los Angeles to pursue acting full time.
He rose to fame with his starring role as Iron Mike in HBO's Tyson before becoming the first African-American to portray a comic-book superhero in a major motion picture with his portrayal of Spawn.
CT HorrorFest is proud to announce Michael Jai White as a guest on July 18, 2015.
Films: Tyson, Spawn, Toxic Avenger II & III, The Dark Knight, Black Dynamite
Ed Neal
Back in 1974, a young student from the University of Texas at Austin auditioned for a role as a hitchhiker in a horror movie that was shooting locally. He went in to his audition, acted as a crazy relative of his and won the part of Nubbins Sawyer in The Texas Chainsaw Massacre. Aside from being a central figure in one of the best horror films of all time and playing Lord Zedd in Mighty Morphin' Power Rangers, this actor is a top voiceover actor in countless cartoons and video games.
CT HorrorFest is thrilled to announce that Ed Neal will be appearing on July 18, 2015.
Films: The Texas Chainsaw Massacre, JFK, Mighty Morphin' Power Rangers
John Dugan
A young actor doing a children's play in Chicago received a phone call from his sister's husband with the news that he and a friend had written a script and were planning on making it into a movie. The writer, Kim Henkel, asked if he'd be willing to drop everything, come to Texas and check out the script. After reading the script titled Head Cheese, he agreed to play the role of Grandpa Sawyer in the film that was eventually named The Texas Chainsaw Massacre.
CT HorrorFest is thrilled to welcome John Dugan on July 18, 2015.
Films: The Texas Chainsaw Massacre, Texas Chainsaw Massacre: The Next Generation, Texas Chainsaw 3D, Bite School
Felissa Rose
At the tail end of the golden age of slasher films came a fantasticly bizzare entry to the genre called Sleepaway Camp. While most slashers of the era followed similiar storylines, Sleepaway Camp took that recipe and packed it so full of genuine WTF moments that it became an instant classic. Based on the strong performance of then 13 year old Felissa Rose as Angela Baker and one of the craziest endings in horror movie history, Sleepaway Camp is still as amazing and relevant today as it was thirty-two years ago.
CT HorrorFest is thrilled to welcome Felissa Rose to CT HorrorFest on July 18, 2015.
Films: Sleepaway Camp, Return to Sleepaway Camp, Satan's Playground, Love Bites
Melissa Cowan
Back in October of 2010, a new show that few people realized would become one of the biggest television shows of all time debuted and a young Georgia woman was chosen to portray the very first "walker" that Rick Grimes came across as he awoke from his coma and stumbled out of the hospital. The iconic "Bicycle Girl" zombie has since become synonomous with The Walking Dead and is recognized by its fans across the world.
CT HorrorFest is thrilled to announce that Melissa Cowan will be appearing on July 18,2015.
Films: The Walking Dead, Goosebumps, The Vampire Diaries, Halloween 2
The Flatlinerz
Flatlinerz are a hip hop group from NYC. The trio is responsible for introducing the term "Horrorcore" with their 1994 Def Jam album release "USA". In June 2014, The Flatlinerz announced via Facebook, that they have reformed and are working on a new project.
CT HorrorFest is happy to announce the convention debut of the legends of horror rap, The Flatlinerz.
Tyler Green
As a 7 year old child in Litchfield, CT, this guest first began designing his unique creations in a workspace in his parents basement. Fast-forward a few years and he is now a successful SFX artist and inventor as well as the COO of his company, Creative Genius, LLC.
CT HorrorFest is happy to welcome season 6 Face Off finalist Tyler Green back to CT HorrorFest!
Jeff Zornow
"Horror Comic Award" winning artist, Jeff Zornow makes his return to Connecticut in July! He is best known for his work on "Godzilla", "Halloween" and "68".
CT HorrorFest is happy to welcome horror artist, Jeff Zornow back to CT HorrorFest!
Sarah Nicklin
CT HorrorFest is happy to welcome back "the darling of indie horror", Danbury, CT native, Sarah Nicklin. We first fell in love with her in her roles as Amoreena Jones in "The Disco Exorcist" and as Sister Wrath in "Nun of That".
Films: The Sins of Dracula, Alice D, Exhumed, The Disco Exorcist, Zombie Allegiance, Nun of That.
James Balsamo
Independent filmmaker James Balsamo has created many underground movies including "I Spill Your Guts", "Cool as Hell", "Catch of the Day", and his latest film, "Bite School."
We are happy to have James Balsamo return for CT HorrorFest 2015.
Carmine Capobianco
Carmine Capobianco began his career behind the camera but had more fun in front of it. He's co-written many of his earlier movies and has also been credited as assistant director, producer and composer. You can see him have fun in "Psychos in Love", "Galactic Gigolo", "Bikini Bloodbath", "Land of College Prophets", "I Spill Your Guts", "The Sins of Dracula", "Model Hunger" and many more.
Sam Costello
Sam Costello is the creator and writer of the award-winning horror web comic, Split Lip. Split Lip has been published online since 2006 and in print since 2009. It offers over 600 pages of free, original horror comics by rising-star artists from around the world. Split Lip won the "Best Web Comic" award in the 2014 Horror Comic Awards. Costello's short fiction has appeared in Punk Planet, Cemetery Moon, and The Eschatology Journal, among others.
Jason McLeod
Jason McLeod is a paranormal investigator, spiritualist, and empath. He has spent the last 28 years helping individual families deal with both the human spirits who linger in their lives, and the inhuman spirits who seek to ruin them. His training and experience began by following in the footsteps of his close personal friends and mentors - the late Ed Warren and his wife Lorraine, bestselling authors, and movie consultants - who started the modern ghost hunting craze that thrives today. He conducts engaging presentations on the subjects of spirituality, consciousness, quantum physics, meditation, metaphysics, paranormal investigation, and demonology on radio blog broadcasts, and at paranormal conventions, spirituality expositions, in churches and at New Age events throughout the world.
Matthew Summo
Matthew wrote, edited, and lettered his first comic book in 2009, "Until Death" from Ronin Studios. He is currently working on "Dedication" for Double Take Comics.
We will have our first official horror costume contest the day of the event. Those judged to have the best costumes will win the following cash prizes!
First Place: $500
PANEL NAME: Project Traveling Oracle
DESCRIPTION: Special make-up effects artists Tyler Green will offer insight on how is team took an original design from conceptualization to realization. Costume designer Ebony Amber will also explain how costume can play an important role when creating a character from head to toe. Creature performer Alec Green will bring the character to life following the makeup demo.
PANEL NAME: The Amazing World of Horror Comics - Sponsored by Double Take
DESCRIPTION: Join Horror News Network creator, Rob Caprilozzi as he talks to Jeff Zornow, Matthew Summo and Sam Costello about their current projects as well as horror comics in general. Attendees that go to the panel will receive FREE horror comics at the end of the discussion.
PANEL NAME: Costume Contest - Sponsored by The Haunted Graveyard
DESCRIPTION: The costume contest will take place today at 5PM. Cash prizes are as follows: First Place: $500, Second Place: $250, Third Place $100.
PANEL NAME: The Texas Chain Saw Massacre Reunion
DESCRIPTION: You are cordially invited to The Sawyer Family Reunion. Hear stories from the filming of The Texas Chain Saw Massacre as told by Gunnar Hansen, Ed Neal, and John Dugan. A Q&A will follow.
PANEL NAME: Raising Hell with Doug Bradley
DESCRIPTION: Join us for a chat with Doug Bradley about his time on the Hellraiser franchise as Pinhead. A Q&A will follow.
Matrix Conference Center
July 18, 2015 11AM - 8PM
Parking is free of charge.
Children age 10 and under FREE when accompanied by a paying adult.
*Please note - all sales are final.
Here are a bunch of pictures from the inaugural CT HorrorFest.


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The Observation Deck
A blog of opinions on local, state and national issues
Posts filtered on Category
'Legitimate rape' theory has origins in Nazi research
The fallacious claim uttered by a few Republicans during last year's election that "legitimate rape" victims can prevent themselves from getting pregnant stems from research conducted by German anatomists on female political prisoners executed during the Hitler regime, says Emily Bazelon in Slate. [Read More]
Slasher genre is still sexist
Slasher films were criticized for focusing on the killer's pursuit of his victims, who were "mostly naked women running scared," says Holly Derr in Ms. Magazine. But modern remakes, such as "Halloween," have turned "women's bodies into ever-more irrelevant carnage" by focusing "the camera on the act of violence itself," she says. [Read More]
Purity culture promotes rape culture
In purity culture women pledge their bodies to their future husbands: They can't say yes to sex until they're married, at which point they don't "have the right to say no," says Dianna Anderson in RH Reality Check. These religious beliefs prevent women from recognizing healthy sexual encounters, and they compound shame for sexual assault […] [Read More]
Safety begins with sobriety
"Young women are getting a distorted message that their right to match men drink for drink is a feminist issue," says Emily Yoffe in Slate. But "the real feminist message" should be that alcohol intoxication makes you an easy target for sexual predators, she says. [Read More]
Pop songs cater to male desire
Female pop stars such as Madonna and Miley Cyrus aren't as sexually liberated as their songs would suggest, considering a majority of their songwriters are men expressing their own "wishful thinking" on female sexuality, says Mark Joseph in USA Today. [Read More]
Teenage girls are not muses
The public's "quiet acceptance" of news that author J.D. Salinger had relationships with teenage girls, illustrates how our culture still endorses the concept that "genius justifies cruel or abusive treatment of those who serve the artist and his art," says Joyce Maynard in The New York Times. [Read More]
What do you say to an infallible pontiff?
"What would you talk to a pope about if he really did call? I'd want to ask about that infallibility thing. 'No mistakes, ever? This doesn't really match my experience with men'," writes TU blogger Rosemary Armao. "There's the whole feminist agenda I subscribe to that would make for lively conversation. Birth control, women priests, […] [Read More]
Crime inside N.Y.'s prisons
Our opinion: New York has failed to take a straightforward step that could dramatically reduce sexual abuse of female inmates. Few evils exist in humanity like that of sexual assault. Surely in a class of its own would be sexual assault of female prisoners by the very people who are supposed to be guarding and […] [Read More]
Show More


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The Message audio Bible is now available on Bible Gateway! Click to learn more.
53:9 wicked . . . rich. Although people supposed that Jesus was dying as a common criminal, through the intervention of Joseph of Arimathea Jesus was buried in honor. His suffering for sinners had been successfully completed.
violence . . . deceit. He was wise and righteous (1 Pet. 2:22), but died a criminal's death (Luke 23:33).


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Auction price: Register or sign-in to see quarterly averages
or visit the Wine Market Journal
Drink between: 2009 - 2014 (Add My Dates)
Green-tinged golden yellow. Shy tropical fruit nose that developed substantially with air. Tropical fruit, apple, pear and vanilla on the palate. This was muted at first but came around very nicely with air. Should have decanted for 45 minutes or so. Lovely once it arrived. Drink now and over the next year or two.
Absolutely superb once again.
Viscous, toasty ripe exotic fruit/pink grapefruit and integrated subtle capsicum grip. Seems to be holding up longer than I originally expected but should nonetheless be drunk up soonish while maintaining this quality level.
Becoming a bit fuller with age while still much as earlier notes. Approaching end of plateau, drink over next twelve months - still excellent but don't hang around!
Kistler is always excellent!
PnP, and served in a plastic wine glass, so perhaps that was the problem. Not much going on here on the nose or the palate. Glycerin and a bit medicinal and the alcohol is hot on the finish. Good acidity, but no fruit to complement it. Pumped the remainder and will decant and retaste tomorrow--in a proper wine glass!


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Six years on from the first Hot Wuk rave in July 2009 we have thrown over 300 parties and sold more than 100,000 tickets.
Can you imagine how many wines have taken place? How many whistles and horns have been blown? How many tunes have been wheeled up?
Friday 17 July at Trapeze in Shoreditch. Tickets. Facebook. June photos.
Yes. IT'S BACK. The craziest bashment party of the year.
A wave of carnival hype is building and the Hot Wuk Truck Party is where it finally pops OFFFFF. The biggest carnival launch party in London.
Saturday 29 August at Koko in Camden. Tickets. Facebook. 2014 photos.
Get news about your local Hot Wuk
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I'm definitely not a groomer and I only have one shaggy dog to clip every month so I can't speak to how these clippers would hold up under extreme conditions, but for me, they work... Read morePublished on Oct. 2 2011 by A. Gray
It is not bad for a small dog, I've a yorki-poo. However, the clipper (the small one), does not have enough power in order to cut the dog's hair specially in the legs. Read morePublished on Sept. 22 2011 by Chappy
I already had a Wahl grooming kit, but not strong enough to do my Golden's fur. This new kit I bought says that it is meant for thick and heavy fur and it really worked. Read morePublished on Aug. 16 2011 by VickyB


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A&B Guest House
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
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TripAdvisor Reviews A&B Guest House Hua Hin
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Allan and Tena thai the knot
Sawasdee, friends! Wedding day has finally arrived. And it surely did not disappoint.
As you can imagine, a traditional Thai wedding differs from a traditional American wedding in a few ways. For one, it's an all day affair, lasting from about 8:30 in the morning to about 10:30 that night. It also includes a monk or two that bless the marriage during the ceremony. Oh, the groom also parades into ceremony on an elephant, preceded by dancers and musicians, while his ...
Hua Hin House Stay - What a Pleasure.
... house. The beach is lovely, there are endless bars and places to eat, massage parlours, great shopping centres... Basically everything you would need for a lovely holiday or even an place to live. We also now have a Thai sim and number too and already made a few local calls! *We are indeed loving the simple things more and more!* Thank you to Peter, Ally & Family who made our Hua Hin stay very welcome and enjoyable. Robyn & Aaron ...
Elephant Sanctuary - Thailand
... also their poop. They also get a shower/wash twice a day, and most days they also go out for a walk around the surrounding area. The feeding and cleaning is done 4 times a day. Every other day the volunteers need to go out for a harvest which takes a couple of hours. This is to gather all the food the elephants will need for the next day. There is banana harvest, where you need your strength as you have to carry banana trees and load them in a ...
Thailand update
... of Thailand. Had a few near death experiences but overall was really fun and the bikes weren't too bad either! Also the cycling gave a really nice breeze! We spent one night there in total as there isn't much to do there. It was very nice to go slightly off the beaten track too away from the business of Bangkok. Both evening we ate ...
Day 362: trains
... Thai girls with too much make-up and too short dresses at every entrance. I smile. They smile back. Sometimes I ask about a cheap cheap guesthouse and they point to a direction. After half an hour, Mohn, a massage lady takes me by the hand and guides me off the main streets through some even narrower and unlit alley to what looks like a private home, but turns out to be a simple guesthouse run by a very old lady. 200 Baht. Clean enough, good enough. Thank ...


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Top Definition
The cracker shack of northern California, with a prep school and an adventist church that ownes everything in the town.
Man, I can't wait to get out of Angwin with all of the yuppie prepies. This place is such a cracker shack!!
by fastcr80 August 28, 2004
1 more definition
Shitty hell hole on earth run by a bunch of god loving freaks that scream sinners on a daily basis, yet they sin and it's ok because they beg for forgivness.
I'd rather goto prison than Angwin.
by Skipunk March 05, 2006


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Auburn's athletics director sides with SEC's decision on scheduling. "The last eight years an SEC team has played for the national championship, and won seven of those. We feel like the eight-game conference format is the right place for us."
Click here for the original story.
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Tapered titanium porous plasma-sprayed components have performed well in primary THA. To confirm the literature at longer followup we retrospectively reviewed all 1639 patients who underwent 2000 THAs in which a specific porous femoral component was used. One hundred fourteen patients (134 hips) were lost to followup leaving a cohort of 1525 patients (1866 THAs). The component is a tapered titanium plasma spray-coated design that remained relatively unchanged since its first implantation except for circumferential proximal porous coating added in 1986 and an offset option added in 1999. Minimum followup was 24 months (average, 119 months; range, 24 to 275 months). To date there have been 39 femoral revisions for an implant survival of 98%. Using the Kaplan-Meier method, cumulative survival with any stem revision as the end point was 98.6% at 5 years, 98.4% at 10 years, 97.1% at 15 years, and 95.5% at 20 years. Using aseptic revision for failure of ingrowth as the endpoint, stem survival was 99.1%. Kaplan-Meier cumulative survival with aseptic revision for failure of ingrowth as the endpoint was 99.4% at 5 years, 99.3% at 10, 15 and 20 years. Harris hip pain and total scores improved. This titanium, porous plasma spray-coated femoral component continues to demonstrate high long-term survival with a low rate of component revision for any reason or aseptic failure of ingrowth.
Level of Evidence: Level IV, therapeutic study (case series). See the Guidelines for Authors for a complete description of levels of evidence.
In the United States, the pendulum of fixation of the femoral component in primary total hip arthroplasty has swung from cemented fixation to cementless fixation, with cementless femoral components used in an estimated 56% of total hip arthroplasties in 2006 [1, 8, 52, 54]. The rationale for this enthusiasm rests in favorable rates of survival observed in multiple mid- and long-term followups of cementless primary hip arthroplasty [2–4, 7, 13–19, 22, 23, 26, 27, 30–35, 38–40, 44–51, 53, 55–58, 60–62, 69]. However, this trend is not the case worldwide. Cemented fixation is favored in some European countries such as England and Sweden [1, 42, 43, 54, 68], although there has been steady increase in the number of cementless femoral components implanted [20, 25, 68].
Modular devices have demonstrated promising results, with survival ranging from 98% at 8.4 years to 99.6% at 11 years [9, 10, 65]. However, concerns exist with respect to corrosion and modular junctions, and potential for increased risk of fretting, osteolysis, and fracture at modular junctions [6]. Cementless straight, cylindrical porous-coated devices have high survival rates ranging from 98% at 11.3 years to over 95% at 15 years [18, 35]. However, these devices may have issues related to thigh pain and perhaps more importantly proximal stress shielding [19]. Anatomic devices have had encouraging reports, with 100% survival at 8.4 years [23]. However, longer-term followup questions the durability of these designs, with failure rates of 11% at 11.2 years and 6% at 15 years [34, 38]. Tapered stems of various designs have enjoyed a high degree of success (Tables 1, ,2)2) [44, 46, 47]. They are appropriate in both Dorr Type A [12] bone typical of young patients [13, 14, 20] and Dorr Type C [12] bone typically seen in older patients [3, 31, 60]. They do not fail from varus malalignment (96% survival at 10 years) [4, 32]. While somewhat prone to proximal fracture at the time of insertion, they have demonstrated high survivorship (100% at 7.5 years) if treated with a proximal cerclage cable or wire [2]. These tapered titanium stems also seem to respect the proximal femur with minimal proximal stress shielding [16, 39, 40, 44–47].
To confirm the literature we first analyzed the survivorship of the first 2000 tapered titanium porous plasma-sprayed femoral components used in primary THA at a single institution. All failures were identified. Second, we sought to define and determine the etiology for failures. Third, we compared pre- and postoperative clinical pain and function scores.
We retrospectively reviewed all 1639 patients who underwent 2000 primary or conversion THAs with a porous femoral component performed by four surgeons (THM, AVL, BKV, RAF) from August 1984 through July 2001. Initially (i.e., from 1984 to 2000) younger patients with Dorr type A or B [12] bone quality were selected for cementless devices. As confidence with the device grew, selection criteria were expanded to include patients with Dorr type C [12] bone and more extensive femoral deformity (from 2000 to 2001). There were 882 (54%) men and 759 (46%) women. The average age of the patients at the time of surgery was 53 years (range, 19–92 years) and the average body mass index was 30.3 kg/m2 (range, 15.3–64.0 kg/m2). The underlying diagnosis was osteoarthritis in 1358 (68%) hips, avascular necrosis in 229 (12%), developmental dysplasia in 138 (7%), posttraumatic arthritis in 109 (6%), rheumatoid arthritis in 61 (3%), Legg-Calvé-Perthes in 47 (2%), slipped capital femoral epiphysis in 36 (2%), ankylosing spondylitis in 13 (1%), acute femoral fracture in four, and failed resurfacing arthroplasty in five. Charnley classification [11] was A (unilateral hip disease) for 793 (40%) hips, B (bilateral disease) for 906 (45%), and C (systemic illness or other joint involvement) for 301 (15%). One hundred fourteen patients (134 hips) were lost to followup before 24 months, despite extensive efforts to locate them, leaving a cohort of 1525 patients (1866 THA). During the followup period, 229 patients (278 hips) died at an average of 8.2 years postoperatively; the status of their hip arthroplasty was known in each patient. There was one perioperative death of a woman who suffered an immediate myocardial infarction. Another woman suffered a fatal pulmonary embolism at 3 weeks postoperatively despite an uneventful course. Minimum followup for surviving patients was 24 months and followup averaged 10.0 years (range, 2–23 years).
The Mallory-Head porous femoral component (Biomet, Inc., Warsaw, IN) was introduced in 1984. Its key characteristics are a proximal-to-distal taper in both the coronal and sagittal planes. Proximal anterior, posterior, and lateral fins engage the cortical-cancellous junction. Finite element analysis demonstrates these fins resist rotational moments about the implant in the proximal femur [45]. The implant is divided into three equal segments of different surface preparations along its length. The proximal third is plasma-sprayed titanium alloy with an average porosity of 43.6% and a coating thickness between 635 and 889 μm. The midsection is grit-blasted with an average surface finish of 30 mesh, and the distal surface is a smooth satin finish. The components range in sizes from 6 mm to 19 mm in 1-mm increments. Initially, the device lacked circumferential plasma spray coating. However, with an enhanced understanding of the need for circumferential endosteal coating, as noted in several studies, circumferential plasma spray was added in 1986 [5, 17, 66, 67]. The component was offered in a standard offset through 1999, when a high offset, lateralized option was added to the product line. The component was designed without a collar to ensure intimate contact of a taper within a taper in the proximal femur. A reduced profile 7° included angle taper neck was incorporated into the prosthesis with anterior and posterior flats to enhance range of motion prior to impingement. Initially, the modular femoral heads were made of titanium alloy, which proved an inferior bearing material and in 1989 chrome-cobalt alloy became the bearing material of choice [41]. Later, options for ceramics were added.
One hundred fifty cases were performed before the introduction of circumferential porous coating. Stems featuring the lateralized offset option were implanted in 130 (7%) hips. The material of the modular femoral head was titanium in 218 (11%) hips, ion-bombarded titanium in 60 (3%), chrome cobalt in 1500 (75%), and ceramic in 222 (11%). Over this period of nearly two decades, a wide variety of acetabular components were utilized, beginning with predominately S-ROM Poly-Dial-type cups (DePuy; 251 hips, 13% overall) and Mallory-Head HexLoc devices (Biomet; 187 hips, 9% overall) and evolving to Mallory-Head RingLoc devices (Biomet; 1307 hips, 65% overall) and M2a-Taper metal-on-metal devices (Biomet; 201 hips, 10% overall).
The surgical technique has remained constant. All operative procedures were performed in a clean-air laminar flow room with all members of the surgical team in personal isolator suits. The operative approach was the direct lateral approach to the hip as described by Frndak et al. [21]. Preoperative templating assisted in the determination of the level of neck resection. The femoral canal was opened with a standard starting femoral reamer. Conical reaming of the proximal femur then followed in a sequential matter. The proximal femur was then broached with incremental sizes of rasps. Phantoms of the true prosthesis without the plasma spray were then used to determine appropriate size and to trial for appropriate leg length. If a proximal fracture occurred during preparation or implantation of the final component, a cerclage cable or wire was placed. Patients were allowed immediate full weight bearing as tolerated with crutches or a walker for a period of 4 to 6 weeks. Patients were advised to progress without ambulatory aids when they were pain-free and without limp.
Patients were followed in the immediate postoperative period at approximately six weeks and encouraged to return yearly thereafter. We (AVL, KRB, THM, BKV, RAF) assessed patients at each followup time using the Harris hip score [24] and beginning in October 2006 using the Lower Extremity Activity Scale [63].
Survival estimates and cumulative survivorship were determined using the Kaplan-Meier method [29], examining both septic and aseptic revisions. Aseptic revisions were further stratified by failure of ingrowth, or revision of a well-fixed stem. All patients enrolled were included in Kaplan-Meier analyses. Patients were censored by date of last followup including those without minimum 2-year. Differences between preoperative and postoperative Harris hip total score and pain component were compared with unpaired Student's t-test. Power analysis was performed using 80%, and confidence intervals were calculated at 95%. All analyses were performed using StatsDirect (StatsDirect Ltd., Altrincham, Cheshire, UK).
We revised 39 (2%) femoral components, with 12 (1%) revisions attributed to failure of ingrowth (Fig. 1A–D) (Table 3). Revisions for failure of ingrowth were performed at an average of 21 months postoperatively (range, 3–69 months). Eight stems were revised as part of two-stage treatment of sepsis at an average of 83 months postoperatively (range, 2–211 months). Six stems were revised secondary to periprosthetic femoral fracture at an average of 70 months postoperatively (range, 0.4–211 months). Twelve well-fixed stems were revised for pain secondary to malalignment in one hip at 29 months postoperatively, secondary to severe osteolysis in 7 hips at an average of 117 months postoperatively (range, 37–242 months), and for reasons unknown in four hips (range, 4–206 months). One well-fixed stem underwent revision at 184 months postoperatively because of component breakage at the neck.
With any revision of the femoral component as the endpoint (Fig. 2), Kaplan-Meier estimated survival proportion was 98.6% at 5 years (1589 at risk, standard error 0.003), 98.4% at 10 years (871 at risk, standard error 0.003), 97.1% at 15 years (380 at risk, standard error 0.006), and 95.5% at 20 years (196 at risk, standard error 0.009).Using aseptic revision of the femoral component for failure of ingrowth as the endpoint (Fig. 3), Kaplan-Meier estimated survival proportion was 99.4% at 5 years (1508 at risk, standard error 0.002), 99.3% at 10 years (795 at risk, standard error 0.002), 99.3% at 15 years (305 at risk, standard error 0.002), and 99.3% at 20 years (121 at risk, standard error 0.002). Using aseptic revision of a well-fixed femoral component as the endpoint (Fig. 4), Kaplan-Meier estimated survival proportion was 99.5% at 5 years (1508 at risk, standard error 0.002), 99.4% at 10 years (795 at risk, standard error 0.002), 98.2% at 15 years (305 at risk, standard error 0.006), and 96.6% at 20 years (121 at risk, standard error 0.01).
The Harris hip pain score [24] increased (p < 0.00001) from a preoperative average of 13 (0–44 possible; range, 0–44) to an average of 38 at most recent evaluation (range, 10–44). The Harris hip total score [24] improved (p < 0.00001) from a preoperative average of 46 (0–100 possible; range, 5–46) to an average of 83 at most recent evaluation (range, 18–100). The lower extremity activity scale [63] averaged 10 (1–18 possible; range, 3–17) at most recent evaluation, with 10 corresponding to the ability to be up and about at will in the house and work outside the house in a minimally active job.
Tapered titanium porous plasma-sprayed components have performed well in primary THA [2–4, 7, 13–17, 22, 26, 27, 30–32, 39, 40, 44–51, 53, 55–58, 60–62]. To confirm the literature at longer followup we analyzed the survivorship of the first 2000 tapered titanium porous plasma-sprayed femoral components used in primary THA at a single institution. We then sought to define and determine the etiology for failures. Finally, we compared pre- and postoperative clinical pain and function scores.
The current series and research project contain several limitations. The project, while encompassing a large volume of patients across a very large demographic range and across more than two decades of practice, has 7% lost to followup. However, based on studies by King et al. [36] and Joshi et al. [28], these patients lost to followup should not substantially detract from our positive overall results. Patients' demographics and factors that could act as independent variables for survivorship analysis were not independently investigated in this study, and this may affect survivorship in specific populations and disease etiologies. Finally, we acknowledge surgeon bias in selection of patients to undergo cementless THA using the stem design. As mentioned previously, early in the experience young patients with good bone quality and normal shape of the femora were selected to receive the cementless device. As our experience increased, confidence with the design grew and the inclusion criteria expanded to encompass elderly patients, those with mild to moderate deformity, and those patients with poor bone quality such as Dorr type C [12].
The overall stem survivorship was 98% with respect to stem revision for any reason. At over 20 years, the survivorship with failure of ingrowth as the etiology for aseptic revision was 99%. During its 24-year life, this stem has gone through only two minor revisions. In 1986, 2 years after its introduction, circumferential porous coating was added. The benefit of this addition was documented by Emerson et al. [17] who reported on 126 Mallory-Head porous components with noncircumferential coating followed an average of 7.8 years. These cases demonstrated remote osteolysis of 11% whereas 90 THAs followed for an average of 7.5 years with circumferential porous coating demonstrated no remote osteolysis. Seven stems in our series (0.4%) underwent revision for osteolysis despite being well fixed. This occurred only in stems without circumferential porous coating. No stem with radiographic signs of osteointegration [44–47] failed from loosening at any point in the 24-year period of study. The only other modification of this implant was the addition of a high offset lateralized component option in 1999. The current authors evaluated 49 cases performed before the availability of the offset stem to 49 cases performed after the availability of the offset stem [53]. Not only did the offset stem assist in a higher percentage of patients obtaining appropriate postoperative offset when compared to preoperative, but also it was associated with a decreased incidence of dislocation and an increased ability to obtain appropriate leg length.
This device has demonstrated applicability in all patient age groups. In this series spanning patients aged 19 to 93 years, we noted substantial and sustained improvement in Harris hip pain and total scores, as well as high lower extremity activity scales at most recent encounter. The current authors have specifically investigated the results of this device in this large patient age span. We reviewed our experience with 249 total hip arthroplasties in 201 patients, age 40 years or younger [14]. Sixty-five percent of these patients were men. Minimum followup for this group of patients was 5 years. In this series, four stems were revised: one for pain of an unknown etiology, another for sepsis, and two for aseptic loosening. One of the two for aseptic loosening was a conversion of a cephalomedullary nail to a THA for failed open reduction internal fixation of a femoral neck fracture. Similar results with this device have been reported in patients age 50 or younger by Dowdy et al. [13]. They reported 100% survivorship at 5.3 years. We also reported 39 total hip arthroplasties in 47 patients, age 74 years or older [3]. Twenty percent of the patients in this study demonstrated Dorr Type C bone [12]. Using aseptic loosening as the end point, 100% survivorship was noted. Reitman et al. [60] reported 72 cementless Mallory-Head Porous implants in 62 patients age 65 and older. Nearly 50% were Dorr Type C bone [12]. Followup averaged 13.2 years and no femoral component revisions for aseptic loosening were performed. Concern may remain that implantation of tapered stems may be complicated by varus malposition or proximal calcar fractures. This porous plasma-sprayed titanium tapered cementless stem was associated with high survival and good results with an average postoperative Harris hip score of 88 despite varus malalignment. We reported a review of 1030 primary Mallory-Head Porous femoral components inserted from 1986 to 1997 [4]. Twenty-six hips (2.4%) in 25 patients were placed in 5° or more varus malalignment. With a mean followup of 10 years and minimum 5 years, one well-fixed stem was revised for unexplained pain for an overall survivorship of 96%. With aseptic loosening as the end point there was 100% survivorship. Similar success with varus angulation of a grit-blasted tapered prosthesis has been reported [32]. In a review of 1320 primary Mallory-Head Porous femoral components, 4% suffered an intraoperative proximal fracture [2]. All patients were treated with either a cerclage wire or cable and immediate full weight bearing. At a minimum followup of 2 years, (mean, 7.5 years; range, 2–16 years), no component suffered substantial subsidence. The key to success with these nondisplaced or minimally displaced proximal femoral fractures is the attainment of fracture and prosthetic stability with cerclage wires or cables [37, 59, 64].
Our data confirm high mid- to long-term survivorship with porous plasma-sprayed titanium tapered cementless stems (Fig. 5A–C). Numerous studies document mid- to long-term followup survivorship of porous plasma-sprayed titanium tapered cementless prosthesis in 97% to 100% of patients. We found the porous plasma-sprayed titanium tapered cementless femoral components versatile. They were appropriate for use in all ages and types of femora. Varus malalignment or proximal femoral fracture did not seem to influence survival. From these data and others, cementless femoral fixation with this device provides ongrowth and is durable.
We thank J. Brooke Harris and Tawnya L. Tucker, M.T., for their assistance in preparation of this manuscript. Cases included in this review include surgeries performed by Bradley K. Vaughn, MD, and Robert A. Fada, MD, during their associations with Joint Implant Surgeons, Inc.
One or more of the authors (AVL, KRB, THM) receive royalties and have consulting agreements with Biomet, Inc. (Warsaw, IN). Institutional financial support is received from Biomet, Inc. Foundation support has been received from Allergan, Biomet, Inc.; GlaxoSmithKline; Medtronics; Merck; Mount Carmel New Albany Surgical Hospital; Pivotal Research Solutions, Inc., Pozen and Tornier.
Each author certifies that his or her institution has approved the human protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Publications (5)20.71 Total impact
- SourceAvailable from: Thomas Wales
Article: Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation.[Show abstract] [Hide abstract]
ABSTRACT: Notch proteins are transmembrane receptors that normally adopt a resting state poised to undergo activating proteolysis upon ligand engagement. Receptor quiescence is maintained by three LIN12/Notch repeats (LNRs), which wrap around a heterodimerization domain (HD) divided by furin cleavage at site S1 during maturation. Ligand binding initiates signaling by inducing sensitivity of the HD to proteolysis at the regulated S2 cleavage site. Here, we used hydrogen exchange mass spectrometry to examine the solution dynamics of the Notch1 negative regulatory region in autoinhibited states before and after S1 cleavage, in a proteolytically sensitive "on" state, and in a complex with an inhibitory antibody. Conversion to the "on" state leads to accelerated deuteration in the S2 region and in nearby secondary structural elements within the HD. In contrast, complexation with the inhibitory antibody retards deuteration around the S2 site. Together, these studies reveal how S2 site exposure is promoted by receptor activation and suppressed by inhibitory antibodies.Structure 04/2011; 19(4):546-54. DOI:10.1016/j.str.2011.01.016 · 6.79 Impact Factor
Article: Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.[Show abstract] [Hide abstract]
ABSTRACT: Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer as well as tumor angiogenesis, making Notch1 a potential therapeutic target. Here we report the in vitro activities of inhibitory Notch1 monoclonal antibodies derived from cell-based and solid-phase screening of a phage display library. Two classes of antibodies were found, one directed against the EGF-repeat region that encompasses the ligand-binding domain (LBD), and the second directed against the activation switch of the receptor, the Notch negative regulatory region (NRR). The antibodies are selective for Notch1, inhibiting Jag2-dependent signaling by Notch1 but not by Notch 2 and 3 in reporter gene assays, with EC(50) values as low as 5+/-3 nM and 0.13+/-0.09 nM for the LBD and NRR antibodies, respectively, and fail to recognize Notch4. While more potent, NRR antibodies are incomplete antagonists of Notch1 signaling. The antagonistic activity of LBD, but not NRR, antibodies is strongly dependent on the activating ligand. Both LBD and NRR antibodies bind to Notch1 on human tumor cell lines and inhibit the expression of sentinel Notch target genes, including HES1, HES5, and DTX1. NRR antibodies also strongly inhibit ligand-independent signaling in heterologous cells transiently expressing Notch1 receptors with diverse NRR "class I" point mutations, the most common type of mutation found in human T-cell acute lymphoblastic leukemia (T-ALL). In contrast, NRR antibodies failed to antagonize Notch1 receptors bearing rare "class II" or "class III" mutations, in which amino acid insertions generate a duplicated or constitutively sensitive metalloprotease cleavage site. Signaling in T-ALL cell lines bearing class I mutations is partially refractory to inhibitory antibodies as compared to cell-penetrating gamma-secretase inhibitors. Antibodies that compete with Notch1 ligand binding or that bind to the negative regulatory region can act as potent inhibitors of Notch1 signaling. These antibodies may have clinical utility for conditions in which inhibition of signaling by wild-type Notch1 is desired, but are likely to be of limited value for treatment of T-ALLs associated with aberrant Notch1 activation.PLoS ONE 02/2010; 5(2):e9094. DOI:10.1371/journal.pone.0009094 · 3.53 Impact Factor
Article: International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials[Show abstract] [Hide abstract]
ABSTRACT: Replication-defective adenoviruses have been utilized as candidate HIV vaccine vectors. Few studies have described the international epidemiology of pre-existing immunity to adenoviruses. We enrolled 1904 participants in a cross-sectional serological survey at seven sites in Africa, Brazil, and Thailand to assess neutralizing antibodies (NA) for adenovirus types Ad5, Ad6, Ad26 and Ad36. Clinical trial samples were used to assess NA titers from the US and Europe. The proportions of participants that were negative were 14.8% (Ad5), 31.5% (Ad6); 41.2% (Ad26) and 53.6% (Ad36). Adenovirus NA titers varied by geographic location and were higher in non-US and non-European settings, especially Thailand. In multivariate logistic regression analysis, geographic setting (non-US and non-European settings) was statistically significantly associated with having higher Ad5 titers; participants from Thailand had the highest odds of having high Ad5 titers (adjusted OR=3.53, 95% CI: 2.24, 5.57). Regardless of location, titers of Ad5NA were the highest and Ad36 NA were the lowest. Coincident Ad5/6 titers were lower than either Ad5 or Ad6 titers alone. Understanding pre-existing immunity to candidate vaccine vectors may contribute to the evaluation of vaccines in international populations.Vaccine 11/2009; 28(4):950-7. DOI:10.1016/j.vaccine.2009.10.145 · 3.49 Impact Factor
Article: Quantitative adenovirus neutralization assays based on the secreted alkaline phosphatase reporter gene: application in epidemiologic studies and in the design of adenovector vaccines.[Show abstract] [Hide abstract]
ABSTRACT: Replication-defective recombinant adenoviruses (rAd) are used as vectors for vaccines as well as for gene therapy. To determine type-specific antibodies to adenovirus (Ad) serotypes 2, 5, 24, 34, and 35, we developed quantitative neutralization assays using recombinant adenoviruses with the secreted alkaline phosphatase (SEAP) reporter gene. Among the standardized parameters, the concentration of infectious and noninfectious adenoviral particles used in the assay is critical for a reliable comparison of data from different studies. The usefulness of this assay was demonstrated in a pilot epidemiologic study of 40 healthy individuals. In this study, the highest prevalence of antiadenovirus antibodies was found for the Ad2 serotype (82.5%), followed by Ad5 (35%). The prevalence of antiadenovirus antibodies for the serotypes 24, 34, and 35 was low (7.5%, 2.5%, and 0%, respectively). In addition, epidemiologic parameters such as gender and age were statistically evaluated. A positive association was found between age and the presence of anti-Ad5 antibodies. The assay was also useful for evaluating the presence of antiadenovirus antibodies in the design of vaccines using a rhesus monkey model. In this animal model, it was possible to determine differential dose and time responses, and the specificity for the detection of neutralizing antibodies was assessed. The evaluation of serotype-specific neutralizing antibodies can be of both clinical and epidemiologic importance as a means of selecting the appropriate serotype adenovector(s).Human Gene Therapy 04/2004; 15(3):293-304. DOI:10.1089/104303404322886147 · 3.62 Impact Factor
Article: Neutralization of Human Papillomavirus (HPV) Pseudovirions: A Novel and Efficient Approach to Detect and Characterize HPV Neutralizing Antibodies[Show abstract] [Hide abstract]
ABSTRACT: The development of vaccines against human papillomaviruses (HPVs) has long been hampered by the inability to grow HPVs in tissue culture and the lack of an efficient neutralization assay. To date, less than 10% of more than 100 different HPV types can be grown in athymic and "SCID" mouse xenograft systems or raft culture systems. Recently, the in vitro generation of HPV pseudovirions and their use in neutralization assays were demonstrated. The major shortcomings of the current approaches to HPV neutralization are the lack of HPV virions for most types for the xenograft methods and the time-consuming and inefficient generation of infective pseudovirions for the latter methods, which precludes their use in large-scale HPV clinical trials or epidemiological studies. We describe here a novel and efficient approach to generating pseudovirions in which HPV virus-like particles (VLPs) are coupled to the beta-lactamase gene as a reporter. We show that it is not necessary to encapsidate the reporter gene constructs into the pseudovirions. Using sera from human volunteers immunized with HPV-11 VLPs expressed in yeast, we demonstrate that our novel neutralization assay compares favorably with the athymic mouse neutralization assay. Furthermore, our assay was used to define neutralizing monoclonal antibodies to HPV-6, which were previously unknown.Virology 01/2001; 278(2):570-7. DOI:10.1006/viro.2000.0674 · 3.28 Impact Factor
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July 26th, 2013 (02:27 PM).
White Glint
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• What smartphone operating system are you currently using?
Currently, iOS 5.0.1. For the sake of Jailbreaking and stuff, I prefer this OS version. It's nice, but my iPhone is outdated, so...I need to upgrade because my GB and RAM needs have skyrocketed.
• Have you used other smartphone operating systems? If so, which do you prefer?
Dude, ICS 4.0 on my mom's S3 is so legit. I'm like almost ready to jump ship and get me an S3. In fact, null that last part about upgrading my iPhone, I might just get that S3/S4.
• Why do you prefer this operating system over others?
Truthfully, the only thing keeping me is the fact that I've invested so much time into the phone, and the fact that it's Jailbroken. If I happen to nab an iPhone 4/4S, I might not have to get a S3/S4. But...if not, ICS, here I come~~~
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2 Central Valley Republicans buck their party on immigration vote w/Photo
Rep. Jeff Denham of Turlock and David Valadao of Hanford , were among a handful of Republicans who bucked their party on the vote . Their stance indicates their discomfort with the harsher position many of their House colleagues demanded. Comment?
California to begin work on nation's first bullet train w/Photo
In this Tuesday, July 16, 2013, file photo, an Amtrak conductor checks the time as the passenger train takes on passengers in Hanford, Calif. California's high-speed rail project reaches a milestone Tuesday, Jan. 6, 2015, as officials mark the start of work on the nation's first bullet train, which is designed to whisk travelers at 200 mph between Los Angeles and San Francisco in less than three hours. Comment?
Texan tries to figure out California water law, with mixed results w/Photo
This video clip comes to us from a late-night session of the House Rules Committee on Wednesday, a fascinating display of how one might try to explain the intricacies of California water law to an outsider, in this case panel chairman Rep. Pete Sessions, R-Texas. Rules Committee members were trying to understand why they should send to the floor a new water bill by Central Valley Republicans that has had no review by the committee of jurisdiction and no public hearings or input. Comment?
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Taliban, in Step Toward Peace Talks, Agree to Open Office in Qatar
KABUL—The Taliban said they tentatively agreed to open a political office in Qatar, a step that could help pave the way for direct peace talks to end a decade of war in Afghanistan.
The announcement on Tuesday was the most concrete signal yet that U.S.-led efforts to inject momentum into Afghan peace talks are gaining traction after months of secret meetings and setbacks.
In the insurgents' first statement on the evolving...


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DUBAI, UAE - SEPTEMBER 26: View at Sheikh Zayed Road skyscrapers in Dubai at September 26, 2011. More than 25 skyscrapers taller than 100 meters can be found there.
- Image ID: 85770457
- Copyright: Patrik Dietrich
- Editorial Credit: Patrik Dietrich / Shutterstock.com
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Home » Salad » Cheese Salad » Tomato Cheese Salad » Tomato Mozzarella Salad » Mozzarella And Tomato Salad
Mozzarella And Tomato Salad
15 Oct 2009
|4 Large
|Olive oil
|4 Tablespoon
|Ground black pepper
|To Taste
|Mozzarella cheese
|300 Gram
|Basil leaves
Chop tomatoes in half, then slice finely arrange on four plates.
Trickle a tablespoon of olive oil over each serving, and sprinkle with black pepper.
Lay slices of cheese over tomatoes, and strips of basil over cheese.
Cover with plastic wrap, and refrigerate for 30 minutes before serving.
Rate It
0 Comments
Mozzarella And Tomato Salad Recipe


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Many of our visitors will probably tell you that one of the most famous places in Jamaica is the The Dunn's River Falls [one of our most adored attraction], and they might be accurate but only to some extent.
The truth is, this attraction has only gained prominence since people started to learn more about the beauty and uniqueness of Jamaica when the tourism industry took off some decades ago. There are scores of other places that have equal and even greater social and historical significance to Jamaica.
Taking both history and popular reviews & sentiments into consideration, I have mandated myself to research and present you with these my Top 5 most famous places in Jamaica!
Of course, these are in addition to the same world famous Dunn's River Falls.
Here too are other related pages and places of interest:
Back to Top of famous places in Jamaica.
Go to Beaches in Jamaica from Famous Places in Jamaica OR
Return to My Island Jamaica from Famous Places in Jamaica
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Food Poisoning from a leading brand name
Could b cool but I've already picked the m.m that's getting tatted on me dates been set for over month now. I'm n ink addict!
always wanted to do this!
I too collect art supplies from other countries when I visit.. Now when I use them I m forced to remember the trip!
the small words on the bottom: "if you're into steamy girls with gigantic cups, she's the half fish-half female for you. the best thing is you can pick her up on almost every street corner."
this just works even looks good on the actual sign..


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Effective April 12, 2012, California's Division of Labor Standards Enforcement (the "DLSE") updated the FAQs on the Wage Theft Protection Act, and also posted a revised "Notice to Employee" form providing an updated template that employers can use to satisfy the Act's written notice requirements. The updates reflect a continuing effort by the DLSE to clarify certain ambiguities highlighted by employers in the wake of the Act's January 1, 2012, enactment, which requires employers to provide new hires with written notice specifying, among other items, the employee's rate(s) of pay, designated pay day, whether the employer intends to claim allowances as part of the minimum wage, workers' compensation provider information, and the name, address and telephone number of the employer.
The Revised Notice to Employee Form
The DLSE website provides templates that employers may use to comply with the Act's written notice requirements that contain all of the information that the DLSE deems material and necessary. Employers are not required to use the templates offered by the DLSE so long as the notices they use contain all of the information required by law and contained in the DLSE's template.
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The light of Heaven restore; Give me to see, and Ajax asks no more.
Alexander Pope (1688 - 1744)
Source: The Iliad, book xvii. line 730.
Contributed by: Zaady
For he lives twice who can at once employ The present well, and ev'n the past enjoy.
Source: Imitation of Martial
Chaos of thought and passion, all confused; Still by himself abused or disabused; Created half to rise, and half to fall; Great lord of all things, yet a prey to all; Sole judge of truth, in endless error hurled,- The glory, jest, and riddle of the world.
Source: Essay on Man. Epistle ii. Line 13.
And if I lose thy love, I lose my all.
Source: Eloisa to Abelard, 1717
How vast a memory has Love!
Source: Sappho to Phaon, 1712
Know then thyself, presume not God to scan; The proper study of mankind is man.
Source: Essay on Man. Epistle ii. Line 1.
Here am I, dying of a hundred good symptoms.
The same ambition can destroy or save, And makes a patriot as it makes a knave.
Such labour'd nothings, in so strange a style, Amaze th' unlearn'd and make the learned smile.
Source: Essay on Criticism. Part ii. Line 126.
A little learning is a dang'rous thing; Drink deep, or taste not the Pierian spring: There shallow draughts intoxicate the brain, And drinking largely sobers us again.
Source: Essay on Criticism. Part ii. Line 15.
Copyright © 2015 Gaiam, Inc.


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Swiss firms fret over immigration vote backlash
ZURICH (Reuters) – Nestled between the peaks of the Swiss Alps, the Hotel Schweizerhof has provided rooms for weary skiers and hikers for more than a century, profiting like scores of other businesses from Switzerland's close ties to Europe.
But a shock vote last week to cap all immigration to the landlocked country and introduce quotas for those from the European Union, now threatens to cut the hotel off from the pool of workers on which it relies.
ABB lowers mid-term sales target on sluggish economy
ZURICH, Feb 13 (Reuters) – Swiss engineering group ABB
lowered its target for mid-term sales growth on
Thursday, blaming a slower-than-expected economic recovery and
weaker capital spending by its customers.
The company, which makes products ranging from power grids
for utilities to industrial robots, said sales growth this year
would be challenging as uncertainty in emerging markets, like
China, offset growth in the United States and parts of Europe.
Swiss put immigration worries aside to fete Russian-born snowboarder
ZURICH, Feb 12 (Reuters) – Days after Switzerland voted to impose new barriers to immigration, the surprise victory of a Russian-born snowboarder nicknamed "I-Pod" at the Olympic Games in Sochi has led to an ironic outpouring of national pride.
Images of 25-year-old Iouri Podladtchikov, who defeated favoured American Shaun White to win gold for Switzerland in the halfpipe, adorned the front pages of Swiss newspapers on Wednesday, jostling for space with headlines on the country's plans to curtail an influx of foreigners.
Actelion raises 2014 guidance after full-year results beat
ZURICH, Feb 11 (Reuters) – Actelion raised its
full-year guidance on Tuesday and said its new heart and lung
drug had been very well received in the United States, as it
posted full-year profit that beat expectations.
Europe's largest biotech company has seen its prospects
brighten after regulators in Europe and the United States
approved its big drug hope Opsumit, a treatment for pulmonary
arterial hypertension (PAH), at the end of last year.
Syngenta promises $1 billion in cost cuts by 2018 as profit drops
ZURICH (Reuters) – Syngenta (SYNN.VX: Quote, Profile, Research, Stock Buzz) is aiming to increase cost-cutting to $1 billion a year by 2018, the world's No. 1 crop chemicals maker said on Wednesday after disappointing the market with an 11 percent fall in profit for last year.
Earnings were hit by higher seed production costs, a writedown on seed inventories and lower-than-expected sales in crop protection in the fourth quarter, Chief Executive Mike Mack told Reuters.
Swiss grapple with identity, economy in immigration vote
WINTERTHUR, Switzerland, Feb 4 (Reuters) – Low taxes and
good infrastructure aside, what entrepreneur Thorsten Schwenke
really needs to grow his small Swiss-based business is the right
people, regardless of their nationality.
That's why he is so bewildered by a vote in Switzerland on
Feb. 9 on whether to impose restrictions on immigrants from the
European Union, and by the proposal's increasing popularity in a
country where foreign labour helped forge a powerful economy.
Roche profits rise, payout level prompts M&A questions
BASEL (Reuters) – Roche offered shareholders a lower-than-expected dividend payout after reporting an 18 percent rise in full-year net profit, potentially a sign the Swiss pharmaceuticals group might be keeping its cash for deals.
Roche – the world's largest maker of cancer drugs – has a track record of solid profit growth prompting expectations of a more generous dividend, share buyback or M&A.
Novartis weighs joint ventures, unconventional deals for smaller businesses
BASEL (Reuters) – Novartis (NOVN.VX: Quote, Profile, Research, Stock Buzz) is looking at options, such as joint ventures, for three smaller businesses to bring them in line with its world-leading pharmaceutical operations, it said on Wednesday, in a review due to be completed by the end of summer.
The Basel-based firm has been casting a fresh eye over its operations following the departure of veteran chairman and one-time CEO Daniel Vasella, the architect of the merger of Ciba-Geigy and Sandoz that created Novartis in 1996.
Lonza to focus on pharma as benefits from outsourcing
ZURICH, Jan 23 (Reuters) – Swiss speciality chemicals maker
and life sciences group Lonza said it plans to focus
on the pharmaceutical and biotech market as it benefits from
drugmakers increasingly outsourcing production.
The firm, faced with low-cost competition, a strong Swiss
franc and higher raw material prices, has been undergoing a
structural overhaul since Richard Ridinger took over as Chief
Executive in May 2012.
Roche's schizophrenia drug misses goal in two late-stage trials
ZURICH, Jan 21 (Reuters) – An experimental Roche
drug designed to treat the "negative symptoms" of schizophrenia
failed to meet its main goal in two late-stage studies, dealing
a blow to the Swiss drugmaker's research hopes in the risky area
of brain science.
Results of two Phase III trials found bitopertin in
combination with antipsychotic therapy did not significantly
reduce negative symptoms after 24 weeks of treatment compared
with placebo. A third late-stage study is ongoing.


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While most of us are starting to make the move to living room boxes that are powered by Android or perhaps a custom UI like in Apple TV, there is still always the option of a home theater PC. The name HTPC tends to bring images of loud, massive boxes that run traditional copies of Windows and freeze in the middle of watching or recording your favorite programs. Just like every other piece of electronic equipment, the HTPC has evolved considerably, as you can clearly see with the ZOTAC ZBOX mini.Read More »
Home / Tag Archives: htpc
Wireless Handheld Keyboard and Trackpad for HTPCs?
Some people are perfectly happy using an Xbox 360 or a PS3 as a media player in their living rooms. For the most part, these consoles can handle your MP3 music and your AVI videos. Other people want more, so they hook up their laptops to their HDTVs for added ...Read More »


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The road that later became Historic Route 1 started as a trail during the 1600s. Burned trees marked the way, crude bridges crossed ravines, and canoe ferries transported goods and people across wider rivers. Later, the first horse carrier service would be established in New Jersey.
Driving through New York City requires a steady hand and some edge and attitude. But you'll be rewarded by an indescribable symphony of sights, sounds, and people.
Arthur Avenue Café
2329 Arthur Avenue, Bronx, NY, 10458
Phone: (718) 562-0129
Arthur Avenue Little Italy Bronx
Route 1 and Arthur Avenue, Bronx, NY, 10458
Barnacle BBQ
181 Ease Boston Post Road, Mamaroneck, NY, 10543
Phone: (914) 777-6610
Bronx Zoo
2300 Southern Avenue, Bronx, NY, 10460
2335 Arthur Avenue, Bronx, NY, 10458
Phone: (718) 733-2807


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Book your room at Saman Villas
Superior SuiteMax Occupancy: 2 guests
Deluxe Suite, Pool AccessMax Occupancy: 2 guests
Get an overview of this hotel4.5-star hotel near the beach
Offering direct access to the beach, this Aturuwella hotel is 2.8 mi (4.6 km) from Bentota Beach and within 9 mi (15 km) of Beruwela Harbour and Kande Vihare Temple. Ambalangoda Beach and Kalatura Beach are also within 20 mi (32 km).
Hotel Features
At Saman Villas, hit the nearby beach, dine onsite at Sun Set Lounge, or enjoy a drink at one of the hotel's 1 bars/lounges.
Room Amenities
All rooms are individually decorated and feature free WiFi, pillowtop beds, and iPod docks. Conveniences include dining areas and sitting areas, and guests will appreciate thoughtful touches like pillow menus and bathrobes.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
In addition to an outdoor pool, Saman Villas provides a sauna, a steam room, and a 24-hour fitness center. Public areas are equipped with complimentary high-speed wireless Internet access. Guests can unwind with a drink at one of hotel's 1 bars/lounges. This beach hotel also offers a library, a terrace, and tour/ticket assistance. Complimentary self parking is available on site.
- 24-hour front desk
- Number of bars/lounges - 1
- Dry cleaning/laundry service
- 24-hour fitness facilities
- Pool umbrellas
- Billiards or pool table
- Tours/ticket assistance
- Free WiFi
- Laundry facilities
- Library
- One meeting room
- Garden
- Terrace
- Porter/bellhop
- Free self parking
- Pool sun loungers
- Beach towels
- Sauna
- Steam room
- Outdoor pool
- Wedding services
Family Friendly Amenities
- Outdoor pool
- Free Wi-Fi
- Laundry facilities
- Separate dining area
- DVD player
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- DVD player
- Premium bedding
- Separate sitting area
- Climate control
- Air conditioning
- Phone
- Minibar
- Free bottled water
- Daily housekeeping
- Turndown service
- Private bathroom
- Bathrobes
- Free toiletries
- Hair dryer
- Bidet
- Rainfall showerhead
- Slippers
- Separate bathtub and shower
- In-room safe
- Desk
- Iron/ironing board (on request)
- Separate dining area
- Blackout drapes/curtains
- Cable TV service
- Free WiFi
- MP3 docking station
- iPod docking station
- Room service (24 hours)
- Egyptian-cotton sheets
- Individually furnished
- Individually decorated
- Pillowtop mattress
- Pillow menu
Where to Eat
Sun Set Lounge - Onsite bar.
24-hour room service is available.
Nearby Things to Do
Recreational amenities at the hotel include an outdoor pool, a sauna, a steam room, and a 24-hour fitness center.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Free bicycles on site
- Yoga classes/instruction on site
Spa Services
- Manicures and pedicures
Hotel Policies
Check-in time starts at 2 PM
Minimum check-in age is 18
Check-out time is noon
Payment types
Children and extra beds
- Children under 10 years old are not allowed at this property. All guests 10 or older are welcome.
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
No cribs (infant beds) available
No elevators
No pets or service animals allowed
- New Year's Eve (31 December) Gala Dinner per adult: LKR 39864.00
We should mention
Children 10 years old and younger are not permitted at this property. No pets and no service animals are allowed at this property.


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The Land Before Time: 2 Tales Of Discovery & Friendship DVD
The prehistoric pals of "The Land Before Time" (1988) are back for more adventures in the fantastic double feature "The Land Before Time: 2 Tales Of Discovery & Friendship." In "The Land Before Time X: The Great Longneck Migration" (2003), a young dinosaur and his pals embark on a life-changing journey with a herd of migrating longnecks. In "The Land Before Time XI: Invasion of the Tinysauruses" (2006), our heroes are no longer the smallest critters in the valley when they become the protectors of a group of miniature dinos. Both features offer songs, gentle humor, and family-friendly fun!
Read MoreLess
More Details
- Format: DVD
- Rating: G
- Number of Discs: 1
- Run Time: 166 Minutes
- Region: 1
- Aspect Ratio: Fullscreen
- Studio: Universal Studios
- DVD Release Date: September 19, 2006
- Subtitles: English, Spanish, French
ENGLISH: Dolby Digital 5.1 [CC]
SPANISH: Dolby Digital 5.1
FRENCH: Dolby Digital 5.1
- Director: Charles Grosvenor
- Genre: Kids
- Color: Color
- Release Date: 2003
0.00.0(No reviews)Write a Review
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Thud: My Real Children
Total words: 43687
Files: 4
Tea: Green tea and ginseng -- possibly *too* stimulating
Music: Bach's Flute Sonatas
RSI: terrible, stop typing, seriously
Reason for stopping: end of chapter
That would be another chapter done.
In 1968, in Britain, if you wanted to buy a car, is there any reason not to buy a Volkswagon Beetle?
- Post a new comment
- 20 comments
- Post a new comment
- 20 comments


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
33 year old man | Litchfield Park, AZ, USA | Seeking women 20-35 within 30 miles
What to say
I love to travel and have been to many places around the world already, I am always up for trying new things at least once. Though after a hard week staying in and watching a good flick is always good. I'm a laid back kind of guy who likes to go with the flow, though I can be quit serious when the occasion calls for it. I was in the Air Force for almost six year, until I had to leave the service because of my knees going bad due to the job I had. Currently I am working in the security field and have gone back to college, working toward a new carrier field. My friends would say that I'm an honest, trustworthy, loyal, and dependable friend that can be counted on when needed.
Camping , Coffee and conversation , Cooking , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Shopping/Antiques , Travel/Sightseeing , Watching sports
Baseball, Billiards / Pool, Bowling, Cycling, Inline skating, Other types of exercise, Swimming, VolleyBall, Walking / Hiking, Weights / Machines
I exercise 3-4 times per week.
I like Cats, Fish
Some other viewpoint
Not too familiar with the current hot spots around my area, but always up for finding them.
My taste in movies is quite vast, I like anything from sci-fi to classic films. A couple of my top favorite movies are The Lost Boys, DUNE 1984, The New Guy, and Army of the Dead. As far a music, if it has a good beat then I'll probably like it.
Well I love to go hicking and camping, or just go out to the club to have some fun. I am very diverse in general though, when it comes to doing things. Ill try anything at least once and love to just get up and go every once in a while.
I have recently been reading a manga series called Death Note. It is a good series that has to deal with death and righteousness. Someone that is given the power of death and what this individual chooses to do with this power, takes him down.....
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'9" (175cms)
|4'0" (121cms) to 5'10" (177cms)
|Body type:
|About average
|Slender, About average, Curvy, Athletic and toned, A few extra pounds
|No preference
|Dark brown
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker
|Law enforcement / Security / Military
|No preference
Currently working a position in the security field, while taking college courses
|I'll tell you later
|No preference
|Never Married
|No preference
|Have kids:
|No preference
|Wants kids:
|Not sure
|Definitely, Someday
|Latino / Hispanic, White / Caucasian
|No preference
Spanish Heritage, with Pure white boy
|I'll tell you later
|No preference
|Some college
|No preference


text:
1884 $20 PR64 PCGS. An issue that needs no introduction ...
2004 June Long Beach Signature Sale #349
|Sold for:
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|Auction Ended On:
|Jun 3, 2004
|Item Activity:
6 Internet/mail/phone bidders
515 page views
|Long Beach, CA
Choice 1884 Liberty Double Eagle, A Rare and Coveted Proof-Only Issue1884 $20 PR64 PCGS. An issue that needs no introduction among gold specialists, the 1884 was produced solely in specimen, or proof format. The official mintage is 71 coins, which is fewer than those of the proof-only 1883 and 1887 deliveries. Perhaps not surprisingly, the 1884 is the rarest issue of this trio, but just how rare has been a matter of debate within numismatic circles. For years, Walter Breen's estimate of 16-20 pieces extant was widely accepted as fact. However, Mike Fuljenz and Doug Winter offer a range of just 15-17 coins in the 2000 book Type Three Double Eagles 1877-1907: A Numismatic History and Analysis, and we have also seen estimates of as few as 12 pieces receive credit. Regardless of which of these estimates is closest to the truth, there can be no doubt that our offering of the present specimen represents a numismatic event of undeniable significance.
We are aware of only five other auction appearances for the 1884 Double Eagle over the past nine years:
1. Ex: Harry W. Bass, Jr. Collection (Bowers and Merena, 10/1999), lot 1891, where it realized $46,000. This coin was certified PR63 by PCGS at the time of the sale.
2. Ex: Dallas Bank Collection (Stack's/Sotheby's, 10/2001), lot 94, where it realized $48,875. Cataloged as "Choice Brilliant Proof."
3. Ex: Eagle Collection of Double Eagles (Heritage, 1/2002), lot 4149, where it realized $54,625. Graded PR64 Cameo at NGC.
4. Ex: FUN Signature Sale Platinum Night--The North Shore Collection (Heritage, 1/2004), lot 3225, where it realized $149,500. An exquisite NGC PR66 Cameo specimen.
5. Ex: Long Beach Signature Sale (Heritage, 1/2004), lot 7590, where it realized $103,500. Certified PR63 PCGS.
We do not know the prior pedigree of the specimen that we are offering in the present sale, but we are fairly certain that it is not one of the pieces listed above. This coin is identifiable by a tiny planchet flaw (as produced) in the obverse field before Liberty's brow.
Needle sharp striking definition and dominant reddish-gold color are seen on both sides. The color becomes somewhat variegated in select areas in the obverse field and through the center of the reverse, but all features are uncommonly mark-free for a gold coin of this size. The uniformly reflective finish sparkles as the coin rotates under a light.
From The Greenwich Collection, Part One.(#9100) (PCGS# 9100)
View all of [The Greenwich Collection, Part One]
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text: Jesse Dangerously - Pumpkin Spice Swag (cold and flu season) by rljd published on 2012/09/26 22:05:53 +0000 ALL PUMPKIN EVERYTHING People are raving: "This is, without question, the best song that Jesse Dangerously has ever, or possibly will ever, create." - Mikal kHill "oh whoops I thought you were spam" - "Charlotte" on "Twitter" "makes me actually want a pumpkin flavored latte. weird." - Randy Hogg, 3rd place 2012 Canadian Barista Champion "It's a little preachy." - Wordburglar hear more by Jesse Dangerously at http://www.dangerously.ca


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Yongan Tang @ on
How to be able to use the FDTD tool
On Monday July 6th, the nanoHUB will be intermittently unavailable due to scheduled maintenance. We apologize for any inconvenience this may cause. close
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Hi Yongan;
You need to join the group ACME (Anctive Media Nanophotonics). Then, you'll be able to use the tool.
Regards, Baudilio
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19th Annual Kendall-Jackson Heirloom Tomato Festival
- Food & Drink
- 5007 Fulton Road, Santa Rosa, CA, 95403
Harvest Party!!
Timothy and Rick Keith
Saturday, August 31, 2013 from 12:30 PM to 5:00 PM (PDT)
In a moment that's been a long time coming, Leaf and Vine will be having its first Harvest Party! Come join us as we release our 2011 "Quartz Block" Zinfandel in grand fashion.
Saturday, August the 31st we'll be joined by Southern Chef Extraordinaire Nick Heinrich as he prepares some delicious BBQ.
We will also have Live Music as performed by The Gypsy Trio, Bocce Ball, Horseshoes, Raffles, BBQ and WINE!!! Join Rick and Tim Keith as they pour their wines.
Leaf and Vine is the story of two generations – father and son – working toward the common goal of producing world class, single vineyard, single varietal wines. It's about starting something from the soil, and building it together. They have a story to tell, one filled with adversity, triumphs, and a lot of fun.
We'd like you to follow along while we document the entire process, and with any luck we'll never close the book…just write a new chapter. So come and be a part of the story.
For more information on Leaf and Vine, their wines and their story, call: 707.478.1725 or email: firstname.lastname@example.com.
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