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Publications (144)454.36 Total impact
- PLoS ONE 04/2015; 10(4):e0123704. DOI:10.1371/journal.pone.0123704 · 3.53 Impact Factor
Article: HER3 protein expression in relation to HER2 positivity in patients with primary colorectal cancer: clinical relevance and prognostic value[Show abstract] [Hide abstract]
ABSTRACT: The clinical and prognostic significance of HER3 expression and its relation to HER2 status in primary colorectal cancer (pCRC) were investigated. We retrospectively analysed 365 consecutive cases of pCRC that had been previously evaluated for HER2 status and included their 143 matched lymph node metastases. Immunohistochemistry (IHC) was performed to assess HER3 expression using tissue array methods. Of 364 eligible patients, HER3 overexpression was detected in 251 cases (69 %) (IHC 2+, n = 186 and IHC 3+, n = 65). HER3 overexpression was inversely correlated with histologic grade (p = 0.006), tumour size (p < 0.001), tumour depth (p < 0.001), TNM stage (p = 0.002), lymphatic invasion (p = 0.004), lymph node metastasis (p = 0.013) and distant metastasis (p = 0.039). Moreover, it positively correlated with both HER2 overexpression (p = 0.007) and HER2 gene amplification (p = 0.006). Although HER3 overexpression was associated with longer survival in univariate analysis (p = 0.026), it was not an independent prognostic factor in multivariate analysis (p = 0.359). Moreover, co-alteration of HER3 and HER2 was associated with neither survival nor any clinicopathologic parameter except tumour location in the rectum. Although not an independent prognostic factor for overall survival, HER3 overexpression was associated with several favourable prognostic clinicopathologic parameters. Additionally, HER3 overexpression strongly correlated with HER2 positivity in this cohort of patients.Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 03/2015; 466(6). DOI:10.1007/s00428-015-1747-2 · 2.56 Impact Factor
Article: Performance Characteristics of Nested Polymerase Chain Reaction vs Real-Time Polymerase Chain Reaction Methods for Detecting Mycobacterium tuberculosis Complex in Paraffin-Embedded Human Tissues[Show abstract] [Hide abstract]
ABSTRACT: Objectives: Nucleic acid amplification tests on formalin-fixed, paraffin-embedded (FFPE) tissue specimens enable Mycobacterium tuberculosis complex (MTB) detection and rapid tuberculosis diagnosis in the absence of microbiologic culture tests. We aimed to evaluate the efficacy of different polymerase chain reaction (PCR) methods for detecting Mycobacterium species in FFPE tissues. Methods: We examined 110 FFPE specimens (56 nonmycobacterial cases, 32 MTB, and 22 nontuberculous mycobacteria [NTM] determined by acid-fast bacilli [AFB] culture) to assess five PCR methods: nested PCR (N-PCR) (Seeplex MTB Nested ACE Detection; Seegene, Seoul, South Korea), an in-house real-time PCR (RT-PCR) method, and three commercial RT-PCR methods (AccuPower MTB RT-PCR [Bioneer, Seoul, Korea], artus M tuberculosis TM PCR [Qiagen, Hilden, Germany], and AdvanSure tuberculosis/NTM RT-PCR [LG Life Sciences, Seoul, Korea]). Results: The results of N-PCR, in-house RT-PCR, and AdvanSure RT-PCR correlated well with AFB culture results (concordance rates, 94.3%, 87.5%, and 89.5%, respectively). The sensitivity of N-PCR (87.5%) was higher than that of the RT-PCR methods, although these differences were not statistically significant between N-PCR and the in-house and AdvanSure RT-PCR methods (68.8% and 80.0%, respectively). All the PCR methods had high specificities, ranging from 98.2% to 100%. Only two NTM cases were detected by AdvanSure RT-PCR, implying a very low sensitivity. Conclusions: Well-designed RT-PCR and N-PCR can effectively identify MTB in FFPE specimens.American Journal of Clinical Pathology 09/2014; 142(3):384-90. DOI:10.1309/AJCP2QZRH4ZNPRDD · 3.01 Impact Factor
Article: The Use of Exome Genotyping to Predict Pathological Gleason Score Upgrade after Radical Prostatectomy in Low-Risk Prostate Cancer Patients[Show abstract] [Hide abstract]
ABSTRACT: Background Active surveillance (AS) is a promising option for patients with low-risk prostate cancer (PCa), however current criteria could not select the patients correctly, many patients who fulfilled recent AS criteria experienced pathological Gleason score upgrade (PGU) after radical prostatectomy (RP). In this study, we aimed to develop an accurate model for predicting PGU among low-risk PCa patients by using exome genotyping. Methods We genotyped 242,221 single nucleotide polymorphisms (SNP)s on a custom HumanExome BeadChip v1.0 (Illuminam Inc.) in blood DNA from 257 low risk PCa patients (PSA <10 ng/ml, biopsy Gleason score (GS) ≤6 and clinical stage ≤T2a) who underwent radical prostatectomy. Genetic data were analyzed using an unconditional logistic regression to calculate an odds ratio as an estimate of relative risk of PGU, which defined pathologic GS above 7. Among them, we selected persistent SNPs after multiple testing using FDR method, and we compared accuracies from the multivariate logistic model incorporating clinical factors between included and excluded selected SNP information. Results After analysis of exome genotyping, 15 SNPs were significant to predict PGU in low risk PCa patients. Among them, one SNP – rs33999879 remained significant after multiple testing. When a multivariate model incorporating factors in Epstein definition – PSA density, biopsy GS, positive core number, tumor per core ratio and age was devised for the prediction of PGU, the predictive accuracy of the multivariate model was 78.4% (95%CI: 0.726–0.834). By addition the factor of rs33999879 in aforementioned multivariate model, the predictive accuracy was 82.9%, which was significantly increased (p = 0.0196). Conclusion The rs33999879 SNP is a predictor for PGU. The addition of genetic information from the exome sequencing effectively enhanced the predictive accuracy of the multivariate model to establish suitable active surveillance criteria.PLoS ONE 08/2014; 9(8):e104146. DOI:10.1371/journal.pone.0104146 · 3.53 Impact Factor
Article: HER2 Status in Colorectal Cancer: Its Clinical Significance and the Relationship between HER2 Gene Amplification and Expression[Show abstract] [Hide abstract]
ABSTRACT: This study aimed at determining the incidence and clinical implications of HER2 status in primary colorectal cancer (CRC). HER2 status was investigated in two retrospective cohorts of 365 consecutive CRC patients (cohort 1) and 174 advanced CRC patients with synchronous or metachronous distant metastasis (cohort 2). HER2 status was determined by performing dual-color silver in-situ hybridization (SISH), mRNA in-situ hybridization (ISH), and immunohistochemistry (IHC). The incidence of HER2 protein overexpression (IHC 2+/3+) was approximately 6% (22 of 365 in cohort 1; 10 of 174 in cohort 2). HER2 gene amplification was observed in 5.8% of the patients from cohort 1 and 6.3% of the patients from cohort 2. HER2 gene amplification was more frequently observed in CRCs located in the rectum than in the right and left colon (P = 0.013 in cohort 1; P = 0.009 in cohort 2). HER2 status, determined by IHC, ISH, and dual-color SISH, was not significantly associated with aggressive CRC behaviour or patients' prognosis in both the cohorts. Of the combined cohort with a total of 539 cases, the concordance rate was 95.5% between dual-color SISH and IHC detection methods. On excluding equivocally immunostained cases (IHC 2+), the concordance rate was 97.7%. HER2 mRNA overtranscription, detected by ISH, significantly correlated with protein overexpression and gene amplification (P<0.001). HER2 gene amplification was identified in a minority of CRC patients with high concordance rates between dual-color SISH and IHC detection methods. Although HER2 status did not predict patients' prognosis, our findings may serve as a basis for future studies on patient selection for HER2 targeted therapy.PLoS ONE 05/2014; 9(5):e98528. DOI:10.1371/journal.pone.0098528 · 3.53 Impact Factor
Article: Fat deposition in the tunica muscularis and decrease of interstitial cells of Cajal and nNOS-positive neuronal cells in the aged rat colon[Show abstract] [Hide abstract]
ABSTRACT: Little is known about the time-course of aging on interstitial cells of Cajal (ICC) of colon. The aim of this study was to investigate the change of morphology, ICC and neuronal nitric oxide synthase (nNOS) immunoreactive cells in the aged rat. The proximal colon of 344 Fischer rats at four different ages (6, 31, 74 weeks, and 2 years) were studied. The immunoreactivity of c-Kit, nNOS, anti-protein gene product 9.5(PGP 9.5) and synaptophysin were counted after immunohistochemistry. The c-kit, SCF (stem cell factor; ligand of Kit) and nNOS mRNA were measured by real-time PCR. c-Kit and nNOS protein were assessed by Western blot. Isovolumetric contractile force measurement and electrical field stimulation (EFS) were conducted. The area of intramuscular fat deposition significantly increased with age after 31 weeks. c-Kit immunoreactive ICC and nNOS immunoreactive neurons and nerve fibers significantly declined with age. mRNA and protein expression of c-kit and nNOS decreased with aging. The functional study showed that the spontaneous contractility was decreased in aged rat, whereas EFS responses in the presence of atropine and L-NG-Nitroarginine methyl ester were increased in aged rat. In conclusion, the decrease of proportion of proper smooth muscle, the density of ICC and nNOS immunoreactive neuronal fibers and the number of nNOS immunoreactive neurons during the aging process may explain the aging-associated colonic dysmotility.AJP Gastrointestinal and Liver Physiology 02/2014; 306(8). DOI:10.1152/ajpgi.00304.2012 · 3.74 Impact Factor
Article: Deregulation of the cell polarity protein Lethal giant larvae 2 (Lgl2) correlates with gastric cancer progression[Show abstract] [Hide abstract]
ABSTRACT: We investigated the roles of Lethal giant larvae 2 (Lgl2), an epithelial cell polarity protein, during gastric carcinogenesis and gastric cancer (GC) progression and evaluated the correlation of Lgl2 with epithelial-mesenchymal transition (EMT) markers. Lgl2 protein and mRNA expression were determined by immunohistochemistry and mRNA in situ hybridization in a large series of GC and preneoplastic lesions. Additionally, expression of 7 EMT markers was examined by immunohistochemistry. Loss of membrane Lgl2 staining in GC was observed in 347 of 409 GCs. Lgl2 loss was associated with diffuse histological type (P < 0.001), advanced stage (P = 0.021), and worse prognosis (P = 0.047). Furthermore, Lgl2 loss correlated with reduced E-cadherin expression (P < 0.01) and increased expression of vimentin (P < 0.01). Combined analysis of Lgl2 and the EMT markers, S100A4 and MMP2, improved predictions of patient outcomes. During gastric carcinogenesis, membrane expression of Lgl2 was progressively lost in 4 % of normal mucosa, 75 % of intestinal metaplasia, 58 % of gastric dysplasia, 69 % of intestinal type GC, and 96 % of diffuse type GC. Our results suggest that Lgl2 loss occurs at an early stage of gastric carcinogenesis and contributes to GC progression.Gastric Cancer 12/2013; 17(4). DOI:10.1007/s10120-013-0324-0 · 4.83 Impact Factor
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ABSTRACT: Glioblastomas may develop de novo (primary glioblastomas, P-GBLs) or through progression from lower-grade astrocytomas (secondary glioblastomas, S-GBLs). The aim of this study was to compare the immunohistochemical classification of glioblastomas with clinically determined P-GBLs and S-GBLs to identify the best combination of antibodies for immunohistochemical classification. We evaluated the immunohistochemical expression of epidermal growth factor receptor (EGFR), p53, and isocitrate dehydrogenase 1 (IDH-1) in 150 glioblastoma cases. According to clinical history, the glioblastomas analyzed in this study consisted of 146 P-GBLs and 4 S-GBLs. Immunohistochemical expression of EGFR, p53, and IDH-1 was observed in 62.6%, 49.3%, and 11.1%, respectively. Immunohistochemical profiles of EGFR(+)/p53(-), IDH-1(-)/EGFR(+)/p53(-), and EGFR(-)/p53(+) were noted in 41.3%, 40.2%, and 28.7%, respectively. Expression of IDH-1 and EGFR(-)/p53(+) was positively correlated with young age. The typical immunohistochemical features of S-GBLs comprised IDH-1(+)/EGFR(-)/p53(+), and were noted in 3.6% of clinically P-GBLs. The combination of IDH-1(-) or EGFR(+) was the best set of immunohistochemical stains for identifying P-GBLs, whereas the combination of IDH-1(+) and EGFR(-) was best for identifying S-GBLs. We recommend a combination of IDH-1 and EGFR for immunohistochemical classification of glioblastomas. We expect our results to be useful for determining treatment strategies for glioblastoma patients.The Korean Journal of Pathology 12/2013; 47(6):541-8. DOI:10.4132/KoreanJPathol.2013.47.6.541 · 0.17 Impact Factor
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ABSTRACT: Mesenchymal chondrosarcoma is a rare and aggressive form of chondrosarcoma. The extraskeletal intraspinal type is even rare among the mesenchymal chondrosarcoma cases. We presented a case of a 17-year-old boy pathologically diagnosed with intraspinal mesenchymal chondrosarcoma. MRI showed multiple intradural extramedullary masses with contrast enhancement, without the evidence of brain lesion. On F-FDG PET/CT, hypermetabolism was observed in the lesions matched with enhancement on spine MRI. The lesions were well differentiated from spinal cord. In the case of hypermetabolic lesion in intradural and extramedullary lesion of the spinal cord, mesenchymal chondrosarcoma should be considered for the differential diagnosis.Clinical nuclear medicine 07/2013; DOI:10.1097/RLU.0b013e3182815cd5 · 2.86 Impact Factor
Article: Quantification of median lobe protrusion and its impact on the base surgical margin status during robot-assisted laparoscopic prostatectomy.[Show abstract] [Hide abstract]
ABSTRACT: Protrusion of the median lobe (PML) is thought to add technical difficulty during robot-assisted laparoscopic prostatectomy (RALP). Thus, we quantified PML using preoperative magnetic resonance imaging (MRI) and evaluated its impact on base surgical margin (BSM) status during RALP. The clinical data of consecutive patients who underwent RALP were retrieved from a prospectively registered database. Of the 655 eligible men, 9 patients were excluded because they did not undergo MRI. PML was measured in a T2-weighted mid-sagittal scan. We performed univariate and multiple logistic regression analyses. The mean PML was 8.3 ± 3.6 mm. The rate of positive surgical margins was 17.3 % (73/423) in pathologic stage T2 and 34.6 % (226/646) in all cases. The BSMs were positive in 10.1 % (66/646) of cases. A logistic regression analysis revealed that PML was significantly correlated with BSM positivity in all cases (odds ratio [OR] 1.080, p = 0.026). In particular, they had a stronger correlation with pathologic stage T3 or higher (OR 1.1143, p = 0.004). PML was an independent predictor of BSM positivity (OR 1.113, p = 0.046) in pathologic stage T3 or higher, as were preoperative prostate-specific antigen, prostate size, and pathologic stage. Cases with 10 mm or higher PML had significantly more BSM positivity than cases with <10 mm PML (35.9 vs. 20.1 %, p = 0.012). Protrusion of the median lobe measured using preoperative MRI was significantly correlated with positive BSMs during RALP. Surgeons should pay more attention to patients with 10 mm or higher PML and advanced stages.World Journal of Urology 07/2013; 32(2). DOI:10.1007/s00345-013-1118-z · 3.42 Impact Factor
Article: Protein expression status in mucosal and submucosal portions of early gastric cancers and their predictive value for lymph node metastasis[Show abstract] [Hide abstract]
ABSTRACT: We aimed to find out predictive markers for lymph node (LN) metastasis of early gastric carcinoma (EGC) by separating evaluation of protein expression in mucosa and submucosa considering tumor heterogeneity. We selected 37 pN1-3 EGCs and depth- and size-matched 31 pN0 EGCs as training set and 72 EGCs including 14 pN1-3 EGCs as test set. Protein expression for β-catenin, E-cadherin, N-cadherin, galectin-3, c-MET, TrkB, and Ki-67 was assessed by immunohistochemistry in mucosal (-m) and submucosal (-sm) portions of tumor. In the training set, Ki67-m was higher than in Ki67-sm (mean ± SD: 82.67 ± 11.99% vs 61.79 ± 22.53%, p < 0.001). Altered E-cadherin-sm, high Ki67-m, and high Ki67-sm were correlated with LN metastasis (p < 0.05) and Ki67-sm was independent with lymphatic invasion and desmoplasia (p = 0.015 by multivariate logistic analysis). The test set confirmed Ki67-sm and E-cadherin-sm as predictors of LN metastasis (p < 0.05). Submucosal EGCs with ≥2 predictive factors out of high Ki67-sm, altered E-cadherin-sm, large tumor size (≥3 cm), diffuse type histology, and present lymphatic invasion yielded 100% sensitivity and 90.9% specificity for prediction of LN metastasis in 21 submucosal EGCs of test set. The proliferative activity of tumor in submucosa is suggested to be an independent predictor for LN metastasis in EGC.Apmis 06/2013; 121(10). DOI:10.1111/apm.12119 · 1.92 Impact Factor
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ABSTRACT: Giant cell arteritis (GCA) is a rare disease among Asians. Arteritic anterior ischemic optic neuropathy, which accompanies GCA, has not yet been reported in Koreans. Diagnosis of GCA is difficult if typical symptoms other than visual loss are absent. Here, we report a case of an 83-year-old Korean woman presenting with sudden visual loss in both eyes (oculus uterque, OU). Her visual acuities included perception of light in the right eye (oculus dexter, OD) and perception of hand motion in the left eye (oculus sinister, OS). The results of the Hardy-Rand-Rittler test and Ishihara test showed total dyschromatopsia OU. The Goldmann perimetry test revealed a total field defect OD and paracentral island OS. Fundus examination revealed chalky-white disc swelling OU. Other systemic symptoms and signs were unremarkable. The erythrocyte sedimentation rate, C-reactive protein and platelet count were highly elevated. Temporal artery biopsy revealed multiple lymphocytes and multinucleated giant cells in the arterial media layer. To our knowledge, this is the first report of GCA in a Korean that has been confirmed with temporal artery biopsy. In conclusion, silent GCA can occur in Koreans, and hence, elderly patients presenting with chalky-white disc swelling, and corresponding laboratory findings must be evaluated for GCA.Korean Journal of Ophthalmology 06/2013; 27(3):224-7. DOI:10.3341/kjo.2013.27.3.224
Article: Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression.[Show abstract] [Hide abstract]
ABSTRACT: PURPOSE: Adiponectin, an adipocyte-secreted endogenous insulin sensitizer, appears to play an important role in progression of several malignancies. Expression of adiponectin receptors-AdipoR1 and AdipoR2-has been documented in gastric cancer (GC) cell lines, but its role in GCs is still controversial. We investigated expression level of 2 adiponectin receptors and correlated their expression with prognosis in GC patients. METHODS: We immunohistochemically evaluated AdipoR1 and AdipoR2 expression in 59 non-neoplastic gastric mucosas, 48 gastric adenomas, 250 GCs, and 58 lymph nodes involved by metastatic GC and assessed its association with clinicopathologic characteristics. RESULTS: Expression rates of both receptors increased stepwise in non-neoplastic gastric mucosa, gastric adenoma, intestinal-type GC, and metastatic GC (p < 0.001). AdipoR1 and AdipoR2 expression was observed in 85 (34.0 %) and 118 (47.2 %) GC cases, respectively. Expression rates were higher in intestinal-type GC than in diffuse-type GC (p < 0.001 and 0.016, respectively). AdipoR1 and AdipoR2 expression was more frequent in advanced GC than in early GC (p < 0.001, each) and was associated with lymphatic invasion (p = 0.046 and 0.001, respectively). AdipoR2 expression was associated with poor overall and disease-free survival (p = 0.001 and 0.007, respectively). AdipoR1 expression was associated with poor disease-free survival for intestinal-type GC patients (p = 0.046). In multivariate analysis, AdipoR2 was an independent prognostic factor for intestinal-type GC (p = 0.017). CONCLUSIONS: Adiponectin receptor expression is related to GC development and progression, especially intestinal-type GC. Thus, adiponectin receptor expression can serve as a prognostic marker in GC patients.Journal of Cancer Research and Clinical Oncology 01/2013; 139(4). DOI:10.1007/s00432-013-1379-3 · 3.01 Impact Factor
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ABSTRACT: Intestinal metaplasia (IM) is a premalignant condition. This study aimed to evaluate the correlation between endoscopic and histological findings of IM. The cases of IM were graded by conventional endoscopy, and biopsies were taken from the antrum and body of 1,333 subjects for histological IM diagnosis. Multivariate analyses were performed to identify the factors that affect the sensitivity of endoscopic IM diagnosis. The sensitivity/specificity of endoscopic IM diagnosis based on histology was 24.0%/91.9% for the antrum and 24.2%/88.0% for the body. As indicated by multivariate analysis, the presence of endoscopic atrophic gastritis (AG) (odds ratio [OR], 4.73; 95% confidence interval [CI], 2.07 to 10.79) and the activity of mucosal inflammation (OR, 2.21; 95% CI, 1.08 to 4.54) were associated with the sensitivity of endoscopic IM diagnosis in the antrum, while the presence of endoscopic AG (OR, 8.02; 95% CI, 4.55 to 14.15), dysplasia (OR, 2.40; 95% CI, 1.07 to 5.39), and benign gastric ulcers (OR, 0.35; 95% CI, 0.15 to 0.081) were associated with the sensitivity of endoscopic IM diagnosis in the body. As the sensitivity of endoscopic IM diagnosis was low, a high index of suspicion for IM is necessary in the presence of atrophy, and confirmation by histology is also necessary.Gut and liver 01/2013; 7(1):41-50. DOI:10.5009/gnl.2013.7.1.41 · 1.49 Impact Factor
Article: Is there any association between the severity of lower urinary tract symptoms and the risk of biopsy-detectable prostate cancer in patients with PSA level below 20 ng/ml in multi-core prostate biopsy?[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: To assess whether the severity of lower urinary tract symptoms (LUTS) is associated with the risk of prostate cancer (PCa) detection via a multi (≥12)-core prostate biopsy. METHODS: From January 2004 to May 2011, 3,107 patients underwent transrectal ultrasound (TRUS) prostate biopsies due to elevated PSA levels ranging between 3 and 20 ng/ml or abnormal digital rectal exams (DREs). Multivariate logistic analysis was used to assess the potential association of LUTS and PCa detection via biopsy. The predictive accuracy of the multivariate model was assessed based on the receiver operating characteristics-derived area under the curve. RESULTS: The median International Prostate Symptom Score (IPSS) was 11, and the mean PSA was 6.81 ng/ml. Of the total subjects, PCa was detected from biopsy in 931 (30.0%) patients. In a comparison of 1,465 patients with IPSS ≥11 and 1,642 patients with IPSS <11, those with a higher IPSS were older, had higher PSA and had a larger prostate, but there were no significant differences in the PCa detection rates. However, in multivariate analysis incorporating other associated variables, a higher IPSS was significantly associated with lower odds of PCa detection (P = 0.016). Nevertheless, addition of the IPSS did not significantly increase the accuracy of the multivariate model devised for the detection of PCa (P = 0.098). CONCLUSIONS: Although PCa was detected less commonly among men with higher LUTS, LUTS may not provide additional prognostic information beyond that which can be obtained via previously established prognostic factors. Prostate © 2012 Wiley Periodicals, Inc.The Prostate 01/2013; 73(1). DOI:10.1002/pros.22537 · 3.57 Impact Factor
Article: Overexpression of epithelial-mesenchymal transition-related markers according to cell dedifferentiation: clinical implications as an independent predictor of poor prognosis in cholangiocarcinoma[Show abstract] [Hide abstract]
ABSTRACT: Although increased evidence has suggested that epithelial-mesenchymal transition has been implicated in cancer invasion and is associated with poor prognosis, its significance in cholangiocarcinoma remains unclear. We evaluated the levels of expression of epithelial-mesenchymal transition-related genes and proteins in 2 established human cholangiocarcinoma cell lines with different morphological characteristics and performed transwell cell invasion assays. Furthermore, we investigated the association between altered expression of 6 epithelial-mesenchymal transition-related proteins and clinical outcomes in human cholangiocarcinoma patients (n = 119) by immunohistochemistry using a tissue microarray approach. Comparative analysis of protein and messenger RNA expression revealed that the cell line with less differentiation (JCK) showed increased expression of mesenchymal markers and zinc-finger proteins and decreased expression of epithelial markers. The invasion activity of JCK cells was significantly higher than that of cells from OZ cell lines. Tissue microarray analysis revealed that the combined expression pattern of 6 epithelial-mesenchymal transition-related proteins predicted shortened disease-free survival (13.0 versus 22.0 months, P = .033) and overall survival (23.0 versus 63.0 months, P = .003) and was confirmed as an independent unfavorable prognostic factor for survival in multivariate survival analysis (disease-free survival, P = .028 for the 3 epithelial-mesenchymal transition-related markers; overall survival, P = .010 for the 6 epithelial-mesenchymal transition-related markers). In conclusion, our results suggest that altered expression of a number of epithelial-mesenchymal transition-related genes in tumor cells with poor differentiation may explain their increased invasive ability. Our results also suggest that altered expression of a suite of epithelial-mesenchymal transition-related proteins could be used as a tool to predict poor outcomes in human cholangiocarcinoma patients.Human pathology 10/2012; 43(12). DOI:10.1016/j.humpath.2012.07.004 · 2.81 Impact Factor
Article: A novel PSEN1 H163P mutation in a patient with early-onset Alzheimer's disease: Clinical, neuroimaging, and neuropathological findings[Show abstract] [Hide abstract]
ABSTRACT: We report a novel presenilin 1 gene (PSEN1) mutation (H163P) in a patient with sporadic early-onset Alzheimer's disease. Clinical, molecular, and neuropathological examinations were performed on an index patient, who presented at the age of 34 years with depression and memory disturbances. At the age of 36 years, she exhibited seizures and myoclonus, cerebellar ataxia, and Parkinsonism. A novel mutation at codon 163 was found in PSEN1, which was changed from histidine to proline. Severe atrophy was noted in the frontal and temporal lobes of the brain. A histopathological examination of the frontal cortex revealed senile plaques and severe neurofibrillary tangles. PSEN1 codon 163 could be a mutational hot spot in early-onset Alzheimer's disease, and may result in a homogeneous phenotype similar to that of other patients with codon-163 mutations; thus, widening the spectrum of PSEN1 codon-163-linked phenotypes.Neuroscience Letters 10/2012; 530(2). DOI:10.1016/j.neulet.2012.09.040 · 2.06 Impact Factor
Article: Primary Intracranial Germ Cell Tumor Originating From Septum Pellucidum That Mimics Central NeurocytomaJournal of Clinical Oncology 07/2012; 30(27):e274-7. DOI:10.1200/JCO.2012.42.4176 · 17.88 Impact Factor
Article: Discordance between anaplastic lymphoma kinase status in primary non-small-cell lung cancers and their corresponding metastases[Show abstract] [Hide abstract]
ABSTRACT: Kim H, Xu X, Yoo S-B, Sun P-L, Jin Y, Paik J H, Choe G, Jheon S, Lee C-T & Chung J-H (2012) Histopathology Discordance between anaplastic lymphoma kinase status in primary non-small-cell lung cancers and their corresponding metastases Aims: The anaplastic lymphoma kinase gene (ALK) has attracted considerable attention as a potential molecular target in non-small-cell lung cancer (NSCLC). However, it is unclear whether ALK alterations are acquired during the metastatic progression of NSCLC. Methods and results: ALK status and ALK expression were evaluated in a series of 67 primary NSCLCs and their corresponding metastatic lesions using fluorescence in-situ hybridization and immunohistochemistry. ALK rearrangement was detected in 7.5% (5/67) of the primary tumours and in 9.0% (6/67) of the metastases (P < 0.001). ALK copy number gain (CNG) was detected in 1.5% (1/67) of the primary tumours and in 35.8% (24/67) of the metastases. Whereas ALK rearrangement was detected only in adenocarcinomas, CNG was identified in various histological subtypes of NSCLC. ALK expression was detected in 11.9% (8/67) of the primary tumours and in 25.4% (17/67) of the metastatic lesions. Conclusions: ALK alteration and ALK expression can be acquired during metastatic progression in NSCLC, and ALK CNG is associated with ALK expression.Histopathology 06/2012; 62(2). DOI:10.1111/j.1365-2559.2012.04356.x · 3.30 Impact Factor
Article: Association of 5α-reductase inhibitor use and pathological features of prostate cancer in men undergoing radical prostatectomy.[Show abstract] [Hide abstract]
ABSTRACT: We investigated the association of 5α-reductase inhibitor (5-ARI) treatment with pathologic and biochemical outcome among the contemporary prostate cancer (PCa) patients undergoing radical prostatectomy. We reviewed records of 1,204 men who underwent radical prostatectomy from 2003 to 2010. We estimated association of 5-ARI use with high (≥7) pathologic Gleason score and pathologically nonorgan-confined disease (≥pT3) via logistic regression, and biochemical outcome via Cox proportional hazards regression. Of 1,204 patients, 50 (4.2%) reported having history 5-ARI treatment before radical prostatectomy. Median duration of 5-ARI treatment among the 50 patients was 23.0 months. When adjusted for various factors including age, body mass index, prostate-specific antigen, clinical stage, biopsy Gleason, and prostate volume, history of 5-ARI treatment was revealed to be significantly associated with high (≥7) pathologic Gleason score (P = 0.015). Also, 5-ARI use was observed to significantly associated with higher rates of extraprostatic extension of tumor (P = 0.005) and seminal vesicle invasion (P = 0.003), respectively, when adjusted for same variables. However, 5-ARI use was not demonstrated to be a significant preoperative predictor of biochemical recurrence-free survival in multivariate analysis (P = 0.528). Our results showed 5-ARI treatment may be associated with more aggressive PCa demonstrating higher pathologic Gleason score and advanced pathologic tumor stage in men undergoing radical prostatectomy. However, further investigations via larger-scale, prospective studies would be needed on the actual effect of 5-ARI treatment on PCa-specific morbidity and mortality.The Prostate 04/2012; 72(11):1187-92. DOI:10.1002/pros.22468 · 3.57 Impact Factor
Top Journals
Seoul National University Bundang Hospital
Sŏul, Seoul, South Korea
- Department of Pathology
Seoul National University Hospital
Sŏul, Seoul, South Korea
- • Department of Pathology
- • Department of Urology
- • Department of Ophthalmology
- • Department of Neurosurgery
Seoul National University
Sŏul, Seoul, South Korea
- • Department of Pathology
- • Department of Neurosurgery
- • College of Medicine
Eulji UniversityDaiden, Daejeon, South Korea


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Twenty-six New Englanders honored at Gillette Stadium during the 2015 Myra Kraft Community MVP Awards. Susan Canning of Westfield, Mass. wins grand prize of $25,000 for KEVS Foundation.
The two were part of Project 351's reunion at Gillette Stadium on Saturday.
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Cameron Fleming and the New England Patriots Charitable Foundation participate in school's celebration of family reading program on Wednesday, April 15.
More than 80 athletes showcase their talents in a five-town event.
Nonprofits throughout New England are encouraged to nominate deserving volunteers for the 2015 Myra Kraft Community MVP Awards and an opportunity to receive grants of $25,000, $10,000 and $5,000 in honor of Myra Kraft.
Raffle prize includes four midfield tickets with pregame VIP tailgate passes, four pregame field passes and VIP parking. Proceeds benefit the New England Patriots Charitable Foundation.
The North Shore Flag Football League look to play their part in a Patriots Super Bowl double celebration in Arizona.
On Thursday, the significant others of the players and coaches rolled up their sleeves at the charity's Giving Factory, where they were able to personally help dozens of children in need.
Patriots Chairman and CEO Robert Kraft, Patriots players, employees and other supporters purchased over 250 coats to be donated to men and women in need across New England.
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For Patriots fans living on the other side of the globe, attending a game in Foxborough is the ultimate treat.
The Patriots Charitable Foundation announced $90,000 in grants to 15 local nonprofits in honor of each Patriots Difference Maker named during the 2014 Celebrate Volunteerism initiative.
Patriots DB Devin McCourty has been named as the New England Patriots team nominee for the Walter Payton Man of the Year award.
Fans encouraged to bring new, unwrapped toys to Sunday's game. Toy drive donation bins will be located outside each gate entrance at Gillette Stadium. All who donate will receive a $5 voucher to the Patriots ProShop.
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Reviewed By William T (South Chesterfield, VA) Reviewed for a 2004 Toyota Tacoma —6/24/2015 10:48 PM
I have towed 1200 lbs greatest stopping power since l have owned truck
Reviewed By R (DALLAS, GA) Reviewed for a 2013 Toyota Tacoma —6/23/2015 5:35 AM
I ordered these for my 2013 Tacoma 4x4 with 3" lift along with a set of the green pads. The the setup has a great feel and look really nice also. They fit on the truck perfect and I have no shake in the steering wheel when I press the brakes (this is why I changed the rotors to start with) They are a little pricey but time will tell if they are worth the extra money!
Reviewed By JUSTIN M (DECATUR, AL) Reviewed for a 2005 Toyota Tacoma —6/12/2015 2:10 PM
This is my first and certainly not my last set of EBC pads. I put the 6000 series green stuff pads along with brembo rotors ( not the slotted and drilled ones ) on my 2005 Tacoma. No noise whatsoever. It improved braking, not sure by how many feet. When you stab the pedal the front drops instantly. No darting or pull total control. * Warning will pull your face off under hard braking.
| Toyota Tacoma Access Cab Brakes & Brake Pads
Toyota Tacoma Double Cab Brakes & Brake Pads
| Toyota Tacoma Extended Cab Brakes & Brake Pads
Toyota Tacoma PreRunner Brakes & Brake Pads
| Toyota Tacoma Regular Cab Brakes & Brake Pads
Toyota Tacoma X-Runner Brakes & Brake Pads


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hazardous materials Companies in Mexico
Hazardous Material Compliance, Inc.
based in Doral, FLORIDA (USA)
Hazardous Material Compliance, Inc. was founded in 1986 to assist our customers in meeting the ever changing requirements of the transportation industry. With over 45 years of combined industry experience, our staff is committed to provide our customers with the highest quality of customer service. Whether you are a shipper, an airline, freight forwarder or handling ...
OSEI - Oil Spill Eater International, Corp
based in Dallas, TEXAS (USA)
Oil Spill Eater II (OSE II) is the world's most environmentally safe and cost effective bioremediation process for the mitigation of hazardous waste, spills and contamination virtually anywhere of any size, large or small. OSE II is an environmentally safe cleanup method because it uses natures own bioremediation processes to effectively eliminate hazardous materials.
Rusmar Inc.
based in West Chester, PENNSYLVANIA (USA)
Established in 1986, Rusmar Incorporated develops, manufactures and markets specialized applications for aqueous foam technology. The company holds seven patents for applications in the landfill and hazardous material remediation industries. Rusmar Long Duration Foam is used as alternate daily cover material to save landfill airspace and for the control of dust, odors and ...
3E Company
based in Carlsbad, CALIFORNIA (USA)
3E Company's comprehensive suite of data products and information services enable improved compliance with global Environmental Health & Safety (EH&S) requirements related to the safe manufacturing, distribution, transportation, usage and disposal of chemicals and hazardous products. This full chemical lifecycle approach enables in-house EH&S staff to reduce cost, risk ...
Tetronics (International) Ltd
based in Swindon, UNITED KINGDOM
Tetronics is a global leader in the supply of Waste Recovery Plants. We have the capability to manage the complete deployment lifecycle of a Waste Recovery Plant from initial testing of the waste material at Tetronics' test facility, the most comprehensive in Europe, through to the physical onsite installation of a full commercial plant. Tetronics' patented Plasma Arc ...
Sensor and Decontamination, Inc. (SDI)
based in Binghamton, NEW YORK (USA)
Sensor and Decontamination, Inc. (SDI), in New York and presently doing business in Pennsylvania, develops hazardous materials cleanup, decontamination, and detection systems. A research and development and manufacturing firm with interests in hazardous materials cleanup, decontamination, and detection.
DG Supplies, Inc
based in Cranbury, NEW JERSEY (USA)
DG Supplies is a family-owned and operated small business specializing in packaging, software and services relating to Hazardous Materials and General Shipping.
based in Arlington, VIRGINIA (USA)
The CHEMTREC vision is to be recognized by emergency responders, industry, government, and others as the world's foremost emergency call center for information on hazardous materials. CHEMTREC was established in 1971 by the chemical industry as a public service hotline for emergency responders, such as fire fighters and law enforcement, to obtain information and ...
MSDS Writer, L.L.C
based in Skokie, ILLINOIS (USA)
The need to communicate hazards of chemicals to users is of the utmost importance. The widespread use of chemicals, the development of new chemicals, and the need to re-evaluate the hazards of pre-existing chemicals contribute to the importance of MSDS Compliance. In the United States, the Occupational Safety and Health Administration (OSHA) has created the Hazard ...
SEACOR Environmental Services Middle East
based in Abu Dhabi, UNITED ARAB EMIRATES
SEACOR Environmental Services Middle East is the largest oil, hazardous materials, fire and emergency response company in the Middle East region and part of the largest response network in the world - SEACOR Environmental Services International. With offices in a number of countries and large stocks of equipment and personnel, we undertake planning, response, training and ...


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Quote of the Day
"Not teasing—flirting. Does anyone know the difference? A tease is a con. You press a spot because you know that it can be pressed, and while the sucker is feeling the pleasure or the pain resulting from the pressure, you take something from him. 'Do you have the money? Good. Good. She'll be right down. Wait here; she'll be right here.' And then nothing. A flirt doesn't do that. A flirt does a dance within the context of giving pleasure. Referring to this, referring to that. And suddenly, following the references, you find a little surprise. Nothing enormous. Nothing like 'Feed on me.' Nothing like that. Something small with a bow on it. It's a pleasure. A surprise, and a gift."
-- George W.S. Trow, "Within the Context of No Context," pp. 94-95
Tags: George W. S. Trow, FlirtingPosted at 07:36 PM on Mon. Jan 14, 2013 in category Quote of the Day
Twitter: @ErikLundegaardTweets by @ErikLundegaard
Me and Earl and the Dying Girl
Theeb (Jordan)
Meeting Dr. Sun (Taiwan)
Kurmanjan Datka: Queen of the Mountains (Kyrgyzstan)
Vincent (France)
Top 10 Lists


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Socialist Mayor Proposes Banning All Classic And "Old Bangers" From Paris
Would it surprise you that this is mostly about the climate change hoax?
(Telegraph) Under proposals presented to the city council on Monday, Socialist mayor Bertrand Delanoë intends to outlaw by September 2014 the use of cars and utility vehicles more than 17 years old and lorries or buses more than 18 years old.
Motorcycles built before 2004 will also be forbidden, as the mayor said they were the "most polluting and noisiest".
The "old banger" ban will apply to all vehicles inside the A86 motorway that surrounds the French capital.
Hooray, we're saved!
The plan would "exclude the poorest people from driving in the capital" and turn Paris into an "island for the rich", he told Le Parisien newspaper.
You know, those poor people who rely on older cars. So, what to do?
The Socialists insisted they would introduce "social" measures to help families and businesses update vehicles, including state subsidies to scrap old cars for new ones — a move experts dubbed unrealistic given the huge cost of such a measure at a time of austerity.
Why, yes, they'll offer more money they don't have. Sound familiar? They also propose a whole range of taxes and fees. Why?
They are part of a plan to turn Paris into a Low Emission Zone, cutting emissions by 30 per cent by 2015. Failure to comply with European air pollution norms could see Brussels slap a 100 million-euro fine on France in 2016.
Certainly, all those vehicles, especially the older ones and those that run on diesel, provide quite a bit of actual air pollution, such as NO2, ozone, carbon monoxide, volatile organic compounds (VOCs) which create smog, and particulate matter. But, this is aimed at reducing CO2 which has been so devastating that there has been no change in the world temperature over the last 16 years.
I find it interesting how Warmist doctrine always seems to resemble Big Government fascism and nanny statism, with the requisite taxes, fees, control, and give backs.
Crossed at Pirate's Cove. Follow me on Twitter @WilliamTeach.
Also see...
Facebook62.5kTwitter76Email1 Considering how often we see horrific stories of animals being abused and murdered by sadistic monsters, it's a nice break to see the often unnoticed acts of kindness towards...Read More
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Here We Go: "Climate Change (Hoax)" Causing The Tornadoes
FacebookTwitterEmail Bill McKibben, founder of the global climate campaign 350.org, is given a platform over at The Washington Post for
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FacebookTwitterEmail Half of America's energy comes from coal-fired power plants but Obama's new EPA rules would about destroy the coal
AGW Today: Polar Bears And Plastic Bags
FacebookTwitterEmail I always get a kick out of these "let's spend time with the cute and fuzzy bunnies*, er, polar


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|ESPN: SportsNation
Andy just finished up with his SportsCenter hit and will be here in a few minutes to take your questions!
Did they remake Doral to have more sand in play? Seems like everyone is in the traps today!
Yeah, they added bunkers, they put them more in play. They brought the water into play on another 5-6 holes. Then you add in that the players haven't played the new course much. The wind is blowing. It's a beast of a course.
was Tiger's 76 as bad as it seemed?
Not really. He actually saved it. It looked like it was going the wrong way. On the 14th, he made a double bogey. The firmness of the green bounced his shot into the bunker. Standing in the fairway for your second shot, you think you hit a good shot and you bounce off. He's had some inconsistency. But when you're not as comfortable as you want and the wind is blowing, it's hard to fake it.
With everyone scrambling today, do you think we'll see a lot of movement up the board? Seems like everyone will be trying to just maintain their position.
The conditions are so tough I wouldn't be surprised if three under is leading at the end of the day. It's all about survival. This has the look of a Sunday at a major the way everyone is struggling.
I wasn't able to watch any of the coverage yesterday....how bad did the weather get that they had to postpone play?
It was lightning and rain. Typical southern Florida. Thinking how ridiculous this would be playing if they didn't get the rain to soften things up.
Does the fact that there is no cut line impact how you approached a tournament?
I don't think so. Other than maybe it gives the player some patience in the second round. He can play around and not force the issue. That's the nice thing for Tiger. He'll get four rounds. Sometimes all it takes is one three hole stretch or six or nine holes and you get something positive. That can feed over into the next week or the next 4-5 tournaments.
Did Jimmy Walker just take advantage of weaker fields earlier this season? Haven't heard much from him since we've had more players in the field now.
He played well on the west coast. He played well out there. He's really a good player. He's come into his own late in his life as a golfer. I really like his game. He has a beautiful swing. He's a good putter. He's got a lot of good coming in the future.
Andy, what's the one thing you think Tiger should work on between now and the Masters?
I don't think there's any one thing. He needs to get some rounds under his belt. He needs to get better, healthier. We'll know more at the end of this week. Bayhill will be important.
how crucial do you think this season is to Tiger's quest for 19?
Very important. He needs to win a major very soon. He's won majors on all four of the courses this year. Right now, I think the 15th is harder than the first one was.
So, what's a good score for today?
Anything even par or better would be a heckuva score. The scoring average right now would be intersting. Anything par or better would be an unbelievable score.
for someone that needs to get some good play in leading up to the masters, tiger just doesn't seem to have his game together right now...what's wrong?
It's hard to tell really where his game is under these conditions. He's hit some good shots. He's hit some bad ones. It's just not real sharp. These conditions can make you look silly. It is important to play practice rounds. He didn't play any. I wouldn't be too concerned where he is.
What do you make of the wrap around season? Do you like it?
I don't like it at all. It's hard enough to figure out what's going on when it's all in one calendar year. I don't think it's right that you have some fields so weak and guys are winning some tournaments that no one in the top 20 is playing.
For the top players that don't play, all of a sudden, you're 12-13 tournaments into the year and you've only played 2.
Since Tiger loves the MAsters so much, do you think that if he doesn't get a good showing there that it could impact his rest of the sesaon?
I think that guys have played poorly there and gone on to win majors after that. I wouldn't put that much into that one week to determining the rest of his year. You've seen a lot of players struggle in the first half and done better the second half. If he doesn't play well, it will just fuel him for the U.S. Open.
When do you think players will try to start positioning themselves to make a run to get on the Ryder Cup team? Or has that already started?
It's already started. A lot of the guys are already talking about it. A player like Jimmy Walker may have already played himself on to the team. The guys are already thinking about it. Trust me.
Seems like everyone is struggling just to make par today....are the scoring conditions that tough?
It's a combination of two things. It's a brand new golf course. When you play at a place like that, the greens are concrete and it's not consistent. Then you add the winds and it's hard to hit the green. Less than 30 percent of the players are hitting the greens on the third hole. It's brutal.
What are the top 3 "musts" for the USA to win the Ryder Cup in September?
No. 1 win matches. No. 2, win matches. No. 3, win more matches than the Euros.
Nice question Dottie. Are you happy to be at home seeing your dog?
Have to ask a non-golf question. As a fellow Monona Grove alum and fellow Badgers fan, is this the year Bo Ryan's boys finally cut down the nets to reach a Final Four?
This year they have an opportunity to do it. If they can take care of business at Nebraska, which won't be easy. It will be important to carry the momentum into the Big Ten tournament. When they're good, they can beat anybody. It will be a fun next 3-4 weeks. If Decker and those guys can stay aggressive they can beat anybody.
Last week at Honda Rory showed some signs from that 2011 Masters choke. He is so talented and many compare him to Woods but you never saw Woods have meltdowns like Rory has. What seperates them?
Rory probably is as physically gifted as Tiger. Tiger has a toughness that you don't see in many athletes. A mental toughness. Will Rory develop that? We'll see. He's still young, but I don't see that same mental toughness, yet. It doesn't mean we won't see it in the next 2-3 years.
what's the biggest thing that tiger needs to make sure he gets in order before the masters?
At The Masters it comes down to putting your ball. There are different speeds. For most at Augusta, if you drive the ball well and putt well, you're going to have a good week. It's all about getting it in the hole.
What would the pros from 30 years ago shoot on this course in these conditions with the old equipment?
These were the conditions that were always very hard, because the ball spun so much. Guys would have figured it out. It's all about trying to shoot scores. We had some pretty good players 25-30 years ago that knew how to do that. If you go back and look, the scores aren't that much different than 20 years ago.
Thanks for paying attention to what we're doing. If you're in the Midwest or Northeast, stay warm. Spring will be here soon!


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Am I Infected?
[2] cunnilingus after had protected vaginal sex
[3] Question about My Potential Risk
[4] Please Help
[5] Is there still a chance i might be HIV negative?
[6] Can I be infected by a Lap dance/Blood test in US?
[7] No risk?
[8] Risks?
[0] Up one level
[#] Next page
[*] Previous page


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Top Definition
An erection that results from having to urinate very badly.
Noah was too shy to use the bathroom at the night club and he wound up getting a poner on the dance floor.
od uživatele Chonky 03. Červen 2007
17 more definitions
A boner from seeing My LIttle Pony: Friendship is Magic content.
This picture of Rainbow Dash licking Twilight Sparkle just gave me a poner.
od uživatele Colgatepony 31. Srpen 2011
A pant boner. The crotch area of any pants or shorts where the zipper rises up, hence making it seem like the person has a boner.
"Dude do you have a boner?"
"No man, it's a poner."
"No man, it's a poner."
od uživatele bakenshake 01. Květen 2010
a pussy boner
Erin: That guys so hot
Olivia: He just gave me a PONER
Harley: Major poner
Olivia: He just gave me a PONER
Harley: Major poner
od uživatele Jesus Christ SAN 04. Prosinec 2009
Portmanteau for "powder boner"; defined as the fictional erection that one gets from skiing on 25+ inches of fresh powder on a bluebird day.
Kyle had a raging poner after shredding the pow-pow all weekend at Sugarbush.
od uživatele Organ Grinder 29. Únor 2012
when you get a boner for no reason other than you have to pee or have been holding pee for a while
i was in the car so long i got a poner
od uživatele pbsbrockton 03. Září 2011
What you call it when you pwn someone or something so hardcore in a game that it gives you an erection.
Dude, did you see that!? I totally just got two headshots with one sniper round! Oh man, I think I'm getting a poner.
od uživatele HoboAC 08. Únor 2008


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The Power of Independent Thinking
Freedom Act, Patriot Act or Status Quo Act
Recorded: Monday, June 8, 2015
Senior Fellow Ivan Eland appears on RTs CrossTalk program to discuss topics surrounding the US Patriot Act and whether or not Edward Snowden was a hero or a traitor. On a panel with other defense analysts, the US war against terror is debated. The panel discusses whether or not the US government is violating the constitutional rights by collecting metadata of phone calls and emails of US citizens.
Experts: Ivan ElandType: TelevisionIssues: Civil Liberties/ Human Rights, Government Power, Government Secrecy, Privacy
Markets Can Heal U.S. Healthcare
Recorded: Wednesday, May 27, 2015
Senior Fellow John C. Goodman, author of A Better Choice, appears on the Wall Street Journals Opinion Live program to discuss how free markets can solve many issues with Obamacare and Americas healthcare system. Goodman talks about which provisions of Obamacare should be changed and which ones should be left alone. Free market principles would level the playing field and give patients the power of choice.
Experts: John C. GoodmanType: TelevisionIssues: Free Market Economics, Health Care, Regulation and Deregulation, Welfare
Mary L.G. Theroux | Childhood Poverty, Government Failures, and the Need for Economic Liberty
Recorded: Thursday, March 26, 2015
Independent Institute Senior Vice President Mary L. G. Theroux testified on "Childhood Poverty, Government Failures, and the Need for Economic Liberty", before the California State Senate's Budget Subcommittee on Health and Human Services, at the request of State Senator Jeff Stone. The witnesses spoke about California's Maximum Family Grant rule for families on welfare. The rule caps grants and does not increase grant money to mothers on welfare when they have more children. Mary testified about the causes of poverty and of the need for other, non-government options for poor families. She introduced ideas for helping the poor through private resources and organizations, instead of government agencies where families and women often find themselves trapped in a cycle of poverty.
Experts: Mary L. G. TherouxType: TelevisionIssues: Bureaucracy and Government, Business, Civil Liberties/ Human Rights, Culture/ Society, Economic History and Development (U.S.), Education, Family, Health Care, Housing, Labor and Employment, Politics, Privatization, Public Health/ Consumer Protection, Regulation and Deregulation, Taxes, Welfare, Womens Issues
Peter A. Thiel | Courage Is In Far Shorter Supply Than Genius
Recorded: Tuesday, January 27, 2015
In this clip from "Peter Thiel | Developing the Developed World: Entrepreneurship, Liberty, and the Future," Peter Thiel describes how courage to stand out from the crowd is in far shorter supply than great minds.
Experts: Peter A. ThielType: Independent Institute EventIssues: Bureaucracy and Government, Business, Culture/ Society, Free Market Economics, Freedom, Government Power, Government Waste/Pork, Political Ideology and Philosophy, Politics, Privacy, Privatization, Regulation and Deregulation
Charity vs Government
Recorded: Thursday, December 18, 2014
Sr. Fellow David T. Beito appears on the Fox Business News' "Stossel" to debate whether government or private charity is a better way to abolish poverty. Beito, editor of the book The Voluntary City says that government is outdated and its War on Poverty is a failure.
Experts: David T. BeitoType: TelevisionIssues: Culture/ Society, Economic History and Development (U.S.), Economic Policy, Labor and Employment, Political Ideology and Philosophy, Welfare
C.S. Lewis on Mere Liberty and the Evils of Statism
Recorded: Saturday, August 2, 2014
David J. Theroux, founder and president of The Independent Institute and the C.S. Lewis Society of California, discusses the writings of C.S. Lewis and Lewis's views on individual liberty, natural law and statism.
The presentation was the keynote talk at the first annual conference of Christians for Liberty, that was held at St. Edwards University in Austin, TX, August 2, 2014.
Experts: David J. TherouxType: Other EventIssues: Bureaucracy and Government, Civil Liberties/ Human Rights, Collectivism, Culture/ Society, Education, Family, Freedom, Government Power, Political Ideology and Philosophy, Politics, Privacy, Privatization, Property Rights, Regulation and Deregulation, Religion, Science, Taxes, Welfare
Robert Higgs: The Welfare State
Recorded: Tuesday, June 17, 2014
Robert Higgs discusses the rise of the welfare state in the United States.
For information on The Challenge of Liberty Summer Seminar, click here.
Experts: Robert HiggsType: Challenge of Liberty SeminarsIssues: Bureaucracy and Government, Corporate Welfare, Economic History and Development (International), Economic History and Development (U.S.), Economic Policy, Free Market Economics, Government Power, Government Waste/Pork, History (U.S), Labor and Employment, Political Ideology and Philosophy, Regulation and Deregulation, Social Security, Welfare
Robert Higgs - Crisis, Leviathan, and the National Security State
Recorded: Thursday, February 27, 2014
"Crisis, Leviathan, and the National Security State" by Robert Higgs was a speech sponsored by The Future of Freedom Foundation February 15, 2014 at the 2014 International Students for Liberty Conference in Washington D.C.
Experts: Robert HiggsType: TelevisionIssues: Constitutional Law, Defense and Foreign Policy, Economic Policy, Free Speech, Freedom, Government Power, History (U.S), Nationalism, Political Ideology and Philosophy, Politics, Privacy, Terrorism and National Crises


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Historic rooms with style, warm hospitality and the traditions and values of former times welcome you to the "Zunfthaus zur Schmiden" (Guild House for Blacksmiths).
The Zwyssighaus Inn in Bauen received special mention because it was salvaged and carefully restored. Because of this, we now have the well-managed birthplace of Father Alberik Zwyssig, the composer of the Swiss Psalm.


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
47 year old woman | Atlanta, GA, USA | Seeking men 37-50 within 50 miles
Active within 3 days
As you walk down the Fairway of Life, you must smell the Roses, for you only get to play one round…" Ben Hogan
I guess just because we didn't hit a "hole-in-one" on the first round, doesn't mean we should give up the clubs. With such beautiful topography along the way, there is sure to be the perfect "green" made for each one of us. No, I am not an avid/professional golfer, but in my former life was very close to one and still wonder why we insisted on living on the golf course, dog-leg left! Had to wear a hard-hat to grill out but had a lot of fun with evening glow-ball! What would others say about me…I think my friends and colleagues would say I am very easy-going, passionate and positive about life and the people I share it with. Enthusiastic and definitely more of an "A" type personality; out-going and never meet a stranger; honest, trustworthy, loving and giving...and have been told bring out the best in people, which is definitely one of the greatest compliments I've received. I love spending time outdoors during every season, whether it be playing in the waves on a fabulous beach or zip-lining through the mountains. Possess very little fear, albeit, perhaps at times I should. If that zip-line breaks or a tree jumps out on the ski-slope, I have a strong faith that it was just my time to go. I work hard and have been blessed with a successful career and life. I do travel quite a bit with my job, so while I am very independent, I cherish time together with someone who is secure and confident with himself, intelligent and above all, loves to laugh. I can definitely laugh at myself…and sometimes find myself gullible to some very good jokes…perhaps, yours. I am a professional packer/traveler so can go from casual, corporate to cocktail in a matter of minutes. When I am home, I find it just as fun to throw on a great pair of jeans and baseball cap! Working from home, I just try to make sure my web-cam is OFF when dressed for "Hot Yoga" rather than success by conventional terms! Yes, I do stay active and fit and like the same to be true for the person I want to spend my life with. I adore spontaneous getaways, exciting conversations over dinner and good wine, sporting events that allow me to revert back to cheerleading days and a lot of other in between and to be seen. People have told me I am more of the "Southern Belle," but I'm able to appreciate lots of different cultures and personalities. Absolutely comes with a love for travel (not to mention my job) and one of the most enjoyable parts! I am looking for someone big on life, intelligent and thoughtful, successful without pretension who respects himself and others. I am blessed to have a fabulous family with incredible parents, "best-friend" siblings, as well as, being the ultimate Auntie Beth that spoils my nieces and nephews with pancakes and ice cream breakfast delights in bed. I've just learned the hard-way not to treat them with these kind of delights before they have to play in a game-changing soccer tournament. I do love children and bow down to all of you parents. Should a relationship evolve, I appreciate and respect they will be your top priority and welcome all that goes with it! Anything else you wish to know, please feel free to ask! Very happy person but missing that special guy I want to love and adore forever!
Alumni connections , Book club , Camping , Coffee and conversation , Business networking , Cooking , Dining out , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing sports , Political interests , Religion/Spiritual , Shopping/Antiques , Travel/Sightseeing , Volunteering , Watching sports , Wine tasting
Aerobics, Baseball, Basketball, Cycling, Dancing, Football, Golf, Hockey, Other types of exercise, Running, Skiing, Soccer, Swimming, Tennis / Racquet sports, Walking / Hiking, Weights / Machines, Yoga
I exercise 3-4 times per week.
I like Dogs
Love and grew up around dogs; but travel schedule living independent hasn't afforded me the luxury as of late. Have been fortunate to share the experience of a special few with people I consider close.
Too many to count! Always up for new places and experiences!
Queens University of Charlotte, Charlotte, NC
Enjoy wide range of music, minus some of today's "rap." Watch more movies and national news than TV shows, but can never tire of classic Seinfeld episodes. Love wining, dining and trying new cuisines, from 5-star to a hot-dog at a Braves game
Travel during the week, so weekends are great for relaxing, movies, reading, outdoor outings, sports venues and social events, catching up with friends and family.
Unbroken, by Laura Hillenbrand.... true story of Olympic runner and World War II Hero, Louis Zamperini.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'0" (152cms)
|5'9" (175cms) to 6'5" (195cms)
|Body type:
|About average, Athletic and toned
|No preference
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker, Moderately
|Sales / Marketing
|No preference
|$75,001 to $100,000
|$75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married, Widow / Widower, Currently Separated, Divorced
|Have kids:
|No preference
|Wants kids:
|Not sure
|Not sure
|White / Caucasian
|White / Caucasian
|Christian / Protestant
|Christian / Catholic, Christian / Protestant, Jewish, Spiritual but not religious, Other, Christian / Other
|Bachelors degree
|Bachelors degree, Graduate degree, PhD / Post Doctoral


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The Snyder County Conservation District (SCCD) and others were invited to the Middleburg Middle School to teach kindergarteners about several environmental subjects on May 15, 2015. Students were able to learn about the importance of trees and soils, see actual aquatic invertebrates, look inside owl pellets and make their own bird calls.
Jason Winey, Watershed Specialist, help work with the school and various groups to organize the activities. More information and photos can be viewed here.
Above right photo: Tom Kerstetter, Pheasants Forever Farm Bill Biologist, holds a stuffed owl during his presentation about birds of prey.
Later in the day, two SCCD staff members participated in this year's AG Dairy Days held near Selinsgrove. Click here for a brief synopsis.
The Snyder County Conservation District (SCCD) was invited on June 1, 2015, to speak about water to 5th graders at the West Snyder Elementary School and about birds to one 1st grade class at the Middleburg Elementary School.
Click here for more information about each event.
SCCD also gave conservation awards to two graduating high school seniors. Click here for details.
Snyder County Conservation District (SCCD) worked with Capital RC&D (Capital Resource Conservation & Development) to conduct a tillage survey in the county in June 2015. SCCD was one of 14 conservation districts participating this year.
Data collected from this survey will be given to PA Department of Environmental Protection (DEP) and US Environmental Protection Agency (EPA) for use in modeling and tracking of water quality improvements.
For more information, please download this information sheet about the survey.
The SCCD was invited to give several presentations to Midd-West School District fifth graders in March and April 2015.
In late-March, Jason Winey, Watershed Specialist, gave an educational presentation regarding water quality and aquatics to one fifth grade class in the Middleburg Elementary School. Afterwards, they played a bingo game to reinforce what they learned. (Click here for details.)
On April 1 and 9, several SCCD staff members were invited to give water and soil presentations during Midd-West School District's annual Outdoor Education program for fifth graders at Camp Mt. Luther west of Mifflinburg. Check out the wrap-up for details.
Snyder County farmers thinking of hiring a private consultant to write a manure management plan (MMP) or a nutrient management plan (NMP) can apply for funding assistance through the Snyder County Conservation District.
Interested farmers must complete an application with the Conservation District by Wednesday, July 1, 2015. Applications are available at the office at 10541 Route 522, Middleburg. Contact Barry Spangler, Agricultural Conservation Technician at 570-837-3000, x118, for details. Click here for more details.
Conservation Districts from Columbia, Montour, Northumberland, Snyder and Union Counties, hosted the annual Susquehanna Valley High School Envirothon at Shikellamy State Park's Overlook on April 28. Teams from all five counties' high schools competed against each other and tested their knowledge in five topics: soils, forestry, urban forestry (current issue for 2015), wildlife and aquatics.
The top Snyder County team came from Midd-West High School and placed 5th overall. A team from Selinsgrove Area High School earned the highest in aquatics among all teams and placed 6th overall.
More details about the event can be found here. Top county teams were eligible to compete at the PA Envirothon at the Johnstown and Windbar areas on May 19 & 20. A wrap-up of what happened at the PA Envirothon can be found here.
Update: A similar event was held for middle school students at Montour Preserve near Danville & Washingtonville. A team from Selinsgrove Middle School placed second overall. Visit us later for some details.
PA Department of Environmental Protection (DEP) has produced a Manure Management Plan (MMP) workbook required for farmers to complete who produce, handle or spread manure and are not required to have a nutrient management plan such as concentrated animal operations (CAOs) and concentrated animal feeding operations (CAFOs).
Questions about environmental regulations or manure management planning can be forwarded to Barry Spangler, Agricultural Conservation Technician, 570-837-3000, x118. You can also go to our Agricultural Erosion Prevention, Agricultural Nutrient Management and Agricultural Conservation Assistance web pages for more information.
The SCCD encourages any person who raises livestock and/or crops (no matter the number or type) to contact us. We will schedule to meet with you to explain what is required. It is better to meet with us now instead of meeting someone else later (e.g.: DEP, US Environmental Protection Agency) during a random inspection or responding to a complaint.
Effective Now:
A conservation district is a subdivision of state government that follows county lines as boundaries. Funding for the conservation district's programs is obtained from the Snyder County Commissioners, PA Department of Environmental Protection (DEP) and other agencies. The Snyder County Conservation District (SCCD) was founded in 1956.
The Conservation District now has recently published its annual report for 2014. You can stop by and:
Farmers, Livestock & Horse Owners ...
Do You Have the Following? Nutrient or Manure Management Plan? Ag. E&S or Conservation Plan?
If yes, are they up to date? If not, meet with the Snyder County Conservation District as soon as possible. We will explain what is required of you and point you to the right direction. PA DEP has been conducting inspections throughout Snyder County to determine if farmers are following the new regulations.
Contact us and go to our Agricultural Nutrient Management and Agricultural Erosion Prevention web pages for more details.
The Snyder County Conservation District now has three tenants in our office building. They are:
Snyder County 4-H, with Kathy Weller as Coordinator.
On Wednesdays, a staff person from PA Rep. Fred Keller's office will be available to answer questions in our lower level conference room from 9:00 a.m. to 4:00 p.m.
Almond Tree Senior Solutions, a senior health care business, has moved in our lower level office suite.


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Peter Travers Pairs Wine With Netflix
If you like it, save it!
Save and organize all of the stuff you love in one place.Got it!
If you like something…
Click the heart, it's called favoriting. Favorite the stuff you like.Got it!
Give Peas a Chance
Pea guacamole and other offensive foods
Warning: You might be offended.
Yogurt whipped cream: your new go-to.
Savor the season.
Bagel and lox, in a salad.
A board to go nuts over.


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Summer maximum temperature in northern France over the past century: instrumental data versus multiple proxies (tree-ring isotopes, grape harvest dates and forest fires)
- N. Etien,
- V. Daux,
- V. Masson-Delmotte,
- O. Mestre,
- M. Stievenard,
- M. T. Guillemin,
- T. Boettger,
- N. Breda,
- M. Haupt,
- P. P. Perraud
- … show all 10 hide
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Changes in maximum spring and summer temperature are expected to have impacts on plant phenology and the occurrence of forest fires. Homogenised instrumental records of maximum spring and summer temperature are available in northern France for the past century, as well as documentary records of grape harvest dates and forest fire frequencies. Here we provide a new proxy of seasonal climate obtained by the analysis of latewood tree ring cellulose isotopic composition (δ18O, δ13C and δD), from 15 living oak trees (Quercus petraea) sampled in the Fontainebleau forest, near Paris. For the past 30 years, we have conducted a study on the inter-tree (for oxygen isotopes) and inter-station (for oxygen and hydrogen) isotopic variability. Multiple linear regression statistical analyses are used to assess the response function of documentary and tree-ring isotopic records to a variety of climatic and hydrological parameters. This calibration study highlights the correlation between latewood tree-ring δ18O and δ13C, grape harvest dates and numbers of forest fire starts with maximum growing season (April to September) temperature, showing the potential of multiple proxy reconstructions to assess the past fluctuations of this parameter prior to the instrumental period.
- Title
- Summer maximum temperature in northern France over the past century: instrumental data versus multiple proxies (tree-ring isotopes, grape harvest dates and forest fires)
- Journal
Climatic Change
Volume 94, Issue 3-4 , pp 429-456
- Cover Date
- 2009-06
- 10.1007/s10584-008-9516-8
- Print ISSN
- 0165-0009
- Online ISSN
- 1573-1480
- Publisher
- Springer Netherlands
- Additional Links
- Topics
- Industry Sectors
- Authors
- N. Etien (1) (7)
- V. Daux (1) (2)
- V. Masson-Delmotte (1)
- O. Mestre (3)
- M. Stievenard (1)
- M. T. Guillemin (1)
- T. Boettger (4)
- N. Breda (5)
- M. Haupt (4)
- P. P. Perraud (6)
- Author Affiliations
- 1. Laboratoire des Sciences du Climat et de l'Environnement (IPSL, UMR CEA-CNRS 1572), Gif-sur-Yvette, France
- 7. LSCE, L'Orme des Merisiers, Bâtiment 701, CEA Saclay, 91 191, Gif-sur-Yvette Cedex, France
- 2. Paris 6 University, Paris, France
- 3. Direction de la Climatologie, Météo France, Toulouse, France
- 4. UFZ-Umweltforschungszentrum Leipzig-Halle GmbH, Sektion Hydrogeologie, AG Paläoklimatologie, Halle, Germany
- 5. INRA-Equipe Phytoécologie (UMR INRA-UHP "Ecologie et écophysiologie forestières"), Champenoux, France
- 6. Office National des Forêts, Eure, France


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The divestment movement from Sudan makes clear "indication of the failures in our intellectual culture"
Regions / Sudan
From rallying and letter writing, the Save Darfur movement is now taking a page from history and looking to divestment to end the atrocities in Darfur.
Don't be too surprised, but a tough attitude is the best gift you can give Darfur today.
The latest UN resolution may well be a turning point in stopping genocide. But much hinges on political will.
It's amid the U.S. government's contradictory posturing and less-than-humanitarian geopolitical motives that the activist movement addressing Darfur operates.
How about kicking UN peacekeeping up a notch? A rapid response unit is needed now more than ever.
The U.S. gets an opportunity in February to end the genocide.
A range of U.S.-based advocacy groups, such as Africa Action and Human Rights Watch, as well as the United Nations, are calling for international intervention to stop "ethnic cleansing" in western Sudan.
At the heart of the debate is the question of whether progressives believe that U.S. power can be used for good in Africa or elsewhere in cases of mass killings and other crimes against humanity?
In the first week of January, Sudanese rebels and the Khartoum government signed a pact ending one of Africa's longest wars.


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— Marine
EMILY rescues swimmers when lifeguards can't
By Ben Coxworth - December 19, 2010 5 Pictures
Riptides can carry hapless swimmers out into the ocean very quickly – by the time a lifeguard is able swim out to rescue them, it may be too late. Using a Jet Ski to reach struggling swimmers is one option, although such watercraft can be expensive, problematic to store on-site, and difficult to launch for one person. Now, seaside municipalities can get something cheaper and easier for reaching those swimmers-in-distress: an electric remote-control motorized rescue buoy called EMILY. Read More


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How can I convert a CVPixelBufferRef to an NSImage or CGImageRef? I need to be able to display the contents of the pixel buffer in a Core Animation Layer.
Take the 2-minute tour ×
Stack Overflow is a question and answer site for professional and enthusiast programmers. It's 100% free, no registration required.


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Everything tagged
Latest from The Spokesman-Review
Man arrested after allegedly making bomb threat to Hayden elementary school
Dec. 5, 2014 An elementary school in Hayden was evacuated Friday afternoon after a man called in a bomb threat, the Kootenai County Sheriff's Office reported. 8
Education notes: PFHS seniors plan spaghetti fundraiser
Oct. 31, 2010 in Idaho Voices on Page I6 Seniors at Post Falls High School are raising funds for their graduation party and inviting the community to a spaghetti feed and auction at the school on Saturday. The dinner …


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I adore green smoothies. I make them often and have recently started to include ripe, soft avocados to them when I have one on hand and they make them so, so, so creamy and smooth. Like, give a new definition to smoothie, smooth. Also, the good fat in the avocado keeps me full all morning long! Give these green goodies a whirl (pun intended) and enjoy this amazing … [Read more...]
It's Time to Reclaim Your Frantic Weekday Mornings!
The plan is ready for you! 85 Freezer Friendly, Make-Ahead Breakfasts & Snacks for $140!!! Get it now! Tell me...I'm here to help! What's your biggest struggle on busy weekday mornings? What's working well in your morning routine? Let's talk and help each other out!!! … [Read more...]
Cinnamon Roll Baked Oatmeal ~ NEW 31 Days of Breakfast Recipes
I think we should call this one 'break-ssert' because it's part breakfast, part dessert. I've been dying to share this for a few weeks...I let the $5 Meal Plan members have a sneak peek. And here it finally is! This baked oatmeal is crazy-ridiculously delicious. It's more of a dessert really. Or a weekend breakfast...perhaps a breakfast before a morning of basketball games … [Read more...]
VIDEO: Price Comparison of New Gluten Free Instant Oatmeal Packets vs. DIY Packets
{Subscribe to my YouTube Channel!} So here is the first in a series of 'grocery hacks' or price comparisons for buying a convenience product vs. making it yourself. I'm totally not surprised at who won this 'price comparison' and 'grocery hack' competition. I'm just surprised at by how much they won! And by how it didn't take that long to pull the DIY packets together! I … [Read more...]
Loaded Potato Frittata ~ 31 Days of Skillet Dinner Recipes
If I had to pick my most favorite frittata of all time, it might be this one. Might. I say might, only because I have a hard time calling anything my favorite because I just love food. And breakfast for dinner. And baked potatoes. And baked potatoes in frittata form. Bacon, potato bits, cheese, chives or green onions, sour cream dollop. I think I've said enough. Add … [Read more...]


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There is a 10 million dollar gap in funding that was supposed to be made up by private investors. They don't have those investors yet. Both the City and the Reds have "out" clauses.
Printable View
There is a 10 million dollar gap in funding that was supposed to be made up by private investors. They don't have those investors yet. Both the City and the Reds have "out" clauses.
Boy, I hope they get it done.
I'd hate to see them go somewhere else.
I'm somewhat torn. Sarasota is 4 hours away for me. If they went to Vero, it would be almost an hour closer. But if the went to Bonita Springs (one of the places luring Indians) it would be over 5.....
I think the Arizona option is gone for now......
I hadn't really heard about Vero being an option. Is that really in play or is it just assumed that they'll try to lure anyone they can now that the Dodgers will train in Arizona? Is it still considered a good facility after all these years?
FWIW - the Arizona Sports Authority & the city of Goodyear have made noise that the Indians new facility will be built & designed with the option of adding a 2nd team down the road.
I have no doubts that teams like the Reds & the Orioles will use that as leverage to make sure they get what they want in Florida in regards to facilities, but I highly doubt any more teams will be making the trip west to AZ.
Vero has mixed reviews as a facility these days. The ballpark itself is a little "old school" to say the least. I didn't see the practice facilities.
If Sarasota falls thru, then I assume the other Florida sites that were in the game recently, get back in. For 48 hours, it looked like Orioles might not stay in Ft Lauderdale, and the Orioles drove up the coast and talked to Vero.
Vero claims to be talking to "other clubs". I'm not sure who/why they are talking to anyone, but if I'm the Reds, I'm working a backup plan just in case Sarasota falls thru.
Vero is open in 2008. Bonita Springs would have to build something. And the Indians had been considering a sharing arrangement with Braves in Orlando. Could Bonita build something in 10 months if Sarasota fall apart? I have my doubts.
So Vero and/or Orlando could be new permanent homes or stopgaps to Bonita Springs.
As expected the State portion was approved yesterday.
I want the Rockford Reds back. It's a shame I wasn't old enough to be interested when they were there.


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SparkFun Electronics will be closed on July 3rd, 2015 in observance of Independence Day. Any orders placed after 2:00pm MT on July 2nd will be shipped out after the weekend. Thanks!
Member Since: January 13, 2011
Country: United States
i've done exactly that with this sensor. iirc it only pulls the line low for a second or two though so i set it up with an atmega48 to poll the sensor and turn on the solenoid for 10-15 seconds, and also limit the number of cycles so it can't get stuck on if the sensor fails etc.
a neighbors cat was digging in my aunts garden and apparently it doesn't understand english, but it understands getting blasted with water quite well :)
No public wish lists :(


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I am very pleased with these beautiful floral plq. set. They bring a touch of class to my bedroom.
So beautifully done and absolutely magnificent to look at! Well worth the money and packaged in perfect fashion. Not a delicate petal was broken or damaged.
The flowers are absolutely intricate and exquisite! They are truly works of art. Amazingly wrapped when shipped. Very unique framed artwork, unsurpassed artistry.


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Leave rsnfm a message to find out more.
Forum Post: To ALL FRANCONA lovers...Is it time yet????
Posted 04/19/2011 10:04:59 EDT
Eggplants, you seem to have your head on straighter than the other clowns on this thread. But the crap that these so called "knowledgable" fans spew is idiotic. They're all a bunch of Monday morning q more »
Posted 04/19/2011 09:45:51 EDT
In Response to Re: To ALL FRANCONA lovers...Is it time yet????: RSNFM, We don't hate Francona.I like to think of him as a "frenemy", a friend I have issues with. I'm sure he more »
Posted 04/18/2011 06:23:43 EDT
To all you Francona Haters out there!!! SCREW YOU!!! You're nothing but ignorant assh***s!! Is HE leaving runners on base? Is HE throwing BP to the other teams hitters? Is HE dressed up as Carl Crawfo more »
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Breaking News and Information
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September 14, 2012 | By John Cooke
Mortgages, providing them and buying them, along with business lending and compliance issues were on the agenda Friday at the Congressional Caucus.
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Credit union execs testify at House panel hearing.
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Get Your Gay Access Now!
Category Bareback
Added September 11, 2014
Viewed 892 times
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Tags Anal Sex, Blowjobs, Cum Swallowing
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Vlada and Erik are bored on another lonely Sunday with nothing to do. They played some video-games and tried the whole board-game thing, but since it was only the two of them it got old quick. Neither wanted to go out into the heat, so instead they stayed in on the couch, and soon enough their shirts started to come off. Both of them locked eyes, and off came their jeans as well. Almost as if daring each other to, they both dove on the other's phallus and started to suck it off. It certainly made the day more interesting!
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Press release from Business Wire
Titan Announces Early Settlement Date for Its Tender Offer
Friday, June 04, 2010
Titan Announces Early Settlement Date for Its Tender Offer16:29 EDT Friday, June 04, 2010 QUINCY, Ill. (Business Wire) -- Titan International, Inc. (NYSE: TWI) today announced the early settlement date for its previously announced tender offer to purchase any and all of its outstanding 8% Senior Unsecured Notes due 2012 (the "Senior Notes"). As of 5:00 p.m., New York City time, on June 3, 2010, the previously announced withdrawal deadline, according to information provided by the tender agent, $46,352,000 principal amount of the Senior Notes, representing 23.9% of the principal amount outstanding, had been validly tendered and not validly withdrawn, all of which had validly been tendered on or before 5:00 p.m., New York City time on May 26, 2010, the previously announced early tender time (the "Early Tender Time"). Titan has accepted for purchase all such Senior Notes. Holders of such Senior Notes will receive $1,050 per $1,000 principal amount of the Senior Notes, plus any accrued and unpaid interest up to, but not including, the early settlement date. The early settlement date for such Senior Notes is expected to be June 7, 2010. The tender offer expires at 12:00 midnight, New York City time, on June 10, 2010, unless extended ("Expiration Time"). Holders of Senior Notes that are validly tendered after the Early Tender Time but before the Expiration Time, that have not been validly withdrawn and that are accepted for purchase will receive $1,000 per $1,000 principal amount of the Senior Notes, plus any accrued and unpaid interest up to, but not including, the final settlement date. The tender offer is subject to the satisfaction or waiver of certain conditions, as more fully described in the offer to purchase and Titan's press release, dated May 27, 2010. Titan may amend, extend or terminate the tender offer in its sole discretion. The complete terms and conditions of the tender offer are set forth in the offer to purchase, related letter of transmittal and press release, dated May 27, 2010, and holders are urged to read such tender offer documents carefully. The sole dealer manager for the tender offer is Goldman, Sachs & Co. Questions about the tender offer may be directed to the sole dealer manager at (800) 828-3182 (toll free). Copies of the offer to purchase and related letter of transmittal may be obtained from Global Bondholder Services Corporation, the information agent for the tender offer, at (866) 470-4300 (toll free). The tender offer is being made solely by means of the offer to purchase, the related letter of transmittal and the press release, dated May 27, 2010. Under no circumstances shall this press release constitute an offer to purchase or the solicitation of an offer to sell the Senior Notes or any other securities of the company. No recommendation is made as to whether holders of the Senior Notes should tender their Senior Notes. This press release includes forward-looking statements that involve risks and uncertainties, including risks as detailed in Titan International, Inc.'s periodic filings with the Securities and Exchange Commission, including its annual report on Form 10-K for the year ended December 31, 2009. The company cautions that any forward-looking statements included in this press release are subject to a number of risks and uncertainties and the company undertakes no obligation to publicly update or revise any forward-looking statements. Titan International, Inc., a holding company, owns subsidiaries that supply wheels, tires and assemblies for off-highway equipment used in agricultural, earthmoving/construction and consumer (including all terrain vehicles) applications.


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WNEP Web Staff
Recent Articles
Netflix Arrivals, Departures May 2015
Here's the complete list of what's arriving and leaving Netflix streaming in May. All title dates are subject to change. Available May 1 Beyond Clueless (2014) Jimi: All Is by My Side (2013) Legally Blonde (2001) Legally Blonde 2: Red, White & Blonde (2003) Longmire: Season 3 No No: A Dockumentary (2014) Shameless: Series 10 The Last Waltz (1978) The Prize Winner of Defiance, Ohio (2005) Underclassman (2015) Witnesses: Season 1 Available May 2 Lalaloopsy: Festival of Sugary Sweets (2015) LeapFrog Letter Factory Adventures: Amazing Word Explorers (2015) Available May […]
Photo Gallery: Large Hail
Strong storms moved through the area Monday. Many viewers sent in photos of large hail stones.
Rainbow Photo Gallery
Have a great rainbow photo? Submit it to our Rainbow Photo Gallery
Tax Day Freebies and Deals
Tax season officially ends on April 15. To celebrate, several restaurants and businesses are offering Tax Day freebies and deals. Here are a few of them. Be sure to double-check with locations near you as these "tax freebies" are all subject to change. Burger King is offering a coupon that allows you to buy one Whopper and get one free. Celebrate filing your taxes with a big meal at Outback Steakhouse with this coupon to get 15 percent off at checkout through May 3. Participating […]
One Way to Pass the Time During a Rain Delay
RADFORD, VA — When your baseball game is stalled due to rain, what is there to do? Joust of course! With baseball season upon us, a video originally posted by Radford University to its YouTube page back in 2011 is experiencing a bit of a resurgence on social media. The funny video captures an impromptu jousting match that took place during a Highlanders baseball game.
Blooper: Ouch, Leckey's Face Meets News Camera
While preparing to stream live using Twitter's new Periscope app, Newswatch 16's Ryan Leckey learns the hard way that photobombing can be dangerous. OUCH! #TV #blooper before I went on @WNEP #LeckeyLive today. @CoreyBurns27 whacked me with his camera. 😜 😜😜 pic.twitter.com/J6rn8DUj9u — Ryan Leckey (@RyanLeckey) April 10, 2015 Want to see that again? Here you go! This time via Instagram. Started a Periscope feed and @ryanleckey got hit with a 20 pound camera to the head… Beware when you […]
Dogs Missing After Crash, Owner Turns to Facebook for Help
DUNMORE — Two dogs are missing following a crash over the weekend in Lackawanna County. A car and SUV collided Saturday afternoon on Interstates 84 and 380 in Dunmore. Troopers say a white German Shepherd named "Harley" (seen above) escaped from the SUV. Harley's owner Christopher Gehm has turned to Facebook to help find his companion. A second dog, a mixed-breed named "Shep", ran from the second vehicle involved in the crash. If you see either dog, you're asked to […]
Winter Sunset Photos Slideshow
Photo Gallery: Moon, Venus, and Mars
Skygazers could enjoy a special treat Friday night. Venus, Mars, and a crescent moon appeared close together in the sky. Viewers sent us many photos of the celestial event.
Engagement Announcement Gets Attention as Couple 'Has It Their Way'
NEW BERLIN, Ill. (WGN) — People around the world are laughing at the name on an Illinois couple's engagement announcement. Joel Burger is marrying Ashley King in July, making it the Burger-King wedding. The couple, who were friends in high school and started dating in college, told WGN they've embraced the jokes about their "whopper" of a name and won't let any annoyances "ketchup" with them. To prove it, they broke tradition and put his name first on the engagement […]
'Meet the RailRiders' Special 2015
Tuesday at 7:00 PM Live on WNEP2 Get to know your hometown team before they hit the field for the 2015 season. Join Sharla McBride and Jim Coles, when they meet the Scranton/Wilkes-Barre RailRiders live Tuesday at 7:00 PM on WNEP2. Sharla and Jim will have live interviews with players and coaches. And, they'll take a look at the upcoming season. Join us for 'Meet the RailRiders' on WNEP2.
Pet Slideshow: April 2015
Check out some great pet pics and submit your own!


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CRESTVIEW — Blake Dean has always been a trailblazer. READ MORE
CRESTVIEW — Tim Hatten talks of a trophy case packed with accomplishments. READ MORE
NICEVILLE — It was five minutes before 6 on Monday night, and the Lewis Middle School gym was barely half full. READ MORE
The Florida Fish and Wildlife Conservation Commission is ramping up efforts to stop boating under the influence. READ MORE
CRESTVIEW — There's just something about catching a fish. It doesn't matter how small or large the fish are that are biting, as long as the fish are biting. READ MORE
CRESTVIEW — Bob Sikes easily recalls the 1986 New York Mets' players. Gary Carter, Ray Knight, Mookie Wilson, Keith Hernandez, Dwight Gooden and Daryl Strawberry — Sikes knew them all. And more than knowing these famous players, he was a part of the team. READ MORE
CRESTVIEW — Northwest Florida State College's athletic programs have $4,425 extra with the Rotary Club of Crestview's recent donation. READ MORE
CRESTVIEW — Mustang girls basketball Coach Ryan Gillis and boys Coach Mitch Buckelew have one major goal during their summer camp. "We are just trying to teach them some basics," Gillis said. "We are trying to teach them how to dribble a little bit and the correct way to shoot. READ MORE
CRESTVIEW — One day, Crestview High School's 45 or so aspiring freshman football players might be thankful for Tuesday's hot workout. One day, those baby Bulldogs will appreciate the conditioning needed to compete at Florida's big-school level. READ MORE
CRESTVIEW — Anita and Ronnie Richards have faithfully volunteered with Crestview High School's baseball for more than two decades. And the past 20 years, they have scheduled a few days in early June to help with their mission of love: The Justin Richards Scholarship Baseball Tournament. The event commemorates their oldest son, Justin, who died in a Jan. 20, 1996 car wreck after taking part in a doughnut sale benefiting Crestview's baseball team. READ MORE