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Publications (18)92.57 Total impact
- SourceAvailable from: Matthew G Butler
Article: Microcephaly, intellectual impairment, bilateral vesicoureteral reflux, distichiasis, and glomuvenous malformations associated with a 16q24.3 contiguous gene deletion and a Glomulin mutation[Show abstract] [Hide abstract]
ABSTRACT: Two hereditary syndromes, lymphedema-distichiasis (LD) syndrome and blepharo-chelio-dontic (BCD) syndrome include the aberrant growth of eyelashes from the meibomian glands, known as distichiasis. LD is an autosomal dominant syndrome primarily characterized by distichiasis and the onset of lymphedema usually during puberty. Mutations in the forkhead transcription factor FOXC2 are the only known cause of LD. BCD syndrome consists of autosomal dominant abnormalities of the eyelid, lip, and teeth, and the etiology remains unknown. In this report, we describe a proband that presented with distichiasis, microcephaly, bilateral grade IV vesicoureteral reflux requiring ureteral re-implantation, mild intellectual impairment and apparent glomuvenous malformations (GVM). Distichiasis was present in three generations of the proband's maternal side of the family. The GVMs were severe in the proband, and maternal family members exhibited lower extremity varicosities of variable degree. A GLMN (glomulin) gene mutation was identified in the proband that accounts for the observed GVMs; no other family member could be tested. TIE2 sequencing revealed no mutations. In the proband, an additional submicroscopic 265 kb contiguous gene deletion was identified in 16q24.3, located 609 kb distal to the FOXC2 locus, which was inherited from the proband's mother. The deletion includes the C16ORF95, FBXO31, MAP1LC3B, and ZCCHC14 loci and 115 kb of a gene desert distal to FOXC2 and FOXL1. Thus, it is likely that the microcephaly, distichiasis, vesicoureteral, and intellectual impairment in this family may be caused by the deletion of one or more of these genes and/or deletion of distant cis-regulatory elements of FOXC2 expression.American Journal of Medical Genetics Part A 04/2012; 158A(4):839-49. DOI:10.1002/ajmg.a.35229 · 2.05 Impact Factor
Article: Chromosome 4q deletion syndrome: narrowing the cardiovascular critical region to 4q32.2-q34.3.[Show abstract] [Hide abstract]
ABSTRACT: The 4q deletion syndrome is a rare chromosome deletion syndrome with a wide range of clinical phenotypes. There is limited clinical phenotype and molecular correlation for congenital heart defects (CHDs) reported so far for this region primarily because many cases are large deletions, often terminal, and because high-resolution array has not been reported in the evaluation of this group of patients. CHDs are reported in about 60% of patients with 4q deletion syndrome, occurring in the presence or absence of dHAND deletion, implying the existence of additional genes in 4q whose dosage influences cardiac development. We report an 8-month-old patient with a large mid-muscular to outlet ventricular septal defect (VSD), moderate-sized secundum-type atrial septal defect (ASD), thickened, dysplastic pulmonary valve with mild stenosis and moderate pulmonic regurgitation, and patent ductus arteriosus (PDA). Illumina CytoSNP array analysis disclosed a de novo, heterozygous, interstitial deletion of 11.6 Mb of genomic material from the long arm of chromosome 4, at 4q32.3-q34.3 (Chr4:167236114-178816031; hg18). The deleted region affects 37 RefSeq genes (hg18), including two provisional microRNA stemloops. Three genes in this region, namely TLL1 (Tolloid-like-1), HPGD (15-hydroxyprostaglandin dehydrogenase), and HAND2 (Heart and neural crest derivatives-expressed protein 2), are known to be involved in cardiac morphogenesis. This report narrows the critical region responsible for CHDs seen in 4q deletion syndrome.American Journal of Medical Genetics Part A 03/2012; 158A(3):635-40. DOI:10.1002/ajmg.a.34425 · 2.05 Impact Factor
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ABSTRACT: Milroy disease, also known as primary congenital lymphedema, is a hereditary form of lymphedema with autosomal dominant inheritance. Individuals with Milroy disease are typically characterized by congenital onset of lymphedema of the lower limbs due to hypoplasia of the lymphatic vessels. The genetic basis of most cases of Milroy disease has not been established, although mutations in the vascular endothelial growth factor receptor VEGFR3 (FLT-4) are responsible for some cases with 17 mutations described to date. In this report, we describe a novel VEGFR3 mutation in exon 22 in a four-generation family in which congenital lymphedema segregates in an autosomal dominant manner. In addition to lymphedema, affected family members had other clinical manifestations associated with Milroy disease including hydrocele, ski jump toenails, large caliber veins, and subcutaneous thickening. We screened VEGFR3 for mutations which revealed a novel 3059A>T transversion in exon 22 resulting in Q1020L missense mutation in the second tyrosine kinase domain of VEGFR3. This mutant allele segregated with lymphedema among affected individuals with incomplete penetrance. This is the first report of an exon 22 mutation in Milroy disease.American Journal of Medical Genetics Part A 06/2007; 143A(11):1212-7. DOI:10.1002/ajmg.a.31703 · 2.05 Impact Factor
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ABSTRACT: GATA-2, a transcription factor that has been shown to play important roles in multiple organ systems during embryogenesis, has been ascribed the property of regulating the expression of numerous endothelium-specific genes. However, the transcriptional regulatory hierarchy governing Gata2 activation in endothelial cells has not been fully explored. Here, we document GATA-2 endothelial expression during embryogenesis by following GFP expression in Gata2-GFP knock-in embryos. Using founder transgenic analyses, we identified a Gata2 endothelium enhancer in the fourth intron and found that Gata2 regulation by this enhancer is restricted to the endocardial, lymphatic and vascular endothelium. Whereas disruption of three ETS-binding motifs within the enhancer diminished its activity, the ablation of its single E box extinguished endothelial enhancer-directed expression in transgenic mice. Development of the endothelium is known to require SCL (TAL1), and an SCL-E12 (SCL-Tcfe2a) heterodimer can bind the crucial E box in the enhancer in vitro. Thus, GATA-2 is expressed early in lymphatic, cardiac and blood vascular endothelial cells, and the pan-endothelium-specific expression of Gata2 is controlled by a discrete intronic enhancer.Development 05/2007; 134(9):1703-12. DOI:10.1242/dev.001297 · 6.27 Impact Factor
Article: Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome.[Show abstract] [Hide abstract]
ABSTRACT: The molecular events involved in lymphatic development are poorly understood. Hence, the genes responsible for hereditary lymphedema are of great interest due to the potential for providing insights into the mechanisms of lymphatic development, the diagnosis, prevention and treatment of lymphedema, and lymphangiogenesis during tumor growth. Mutations in the FOXC2 transcription factor cause a major form of hereditary lymphedema, the lymphedema-distichiasis syndrome. We have conducted a study of Foxc2 expression during mouse development using immunohistochemistry, and examined its expression in lymphatics compared to its paralog Foxc1 and to Vegfr-3, Prox1 and other lymphatic and blood vascular proteins. We have found that Foxc2 is expressed in lymphatic primordia, jugular lymph sacs, lymphatic collectors and capillaries, as well as in podocytes, developing eyelids and other tissues associated with abnormalities in lymphedema-distichiasis syndrome.Gene Expression Patterns 11/2004; 4(6):611-9. DOI:10.1016/j.modgep.2004.07.004 · 1.36 Impact Factor
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ABSTRACT: To examine the FOXC2 gene in a family with hereditary distichiasis. Distichiasis, ie, a second row of eyelashes arising from the meibomian glands of the eyelids, can be inherited either alone (Online Mendelian Inheritance in Man [OMIM] no. 126300) or, more commonly, as part of the lymphedema-distichiasis (LD) syndrome (OMIM no. 153400). More than 45 families with mutations in the FOXC2 gene and LD have been described. Both lymphedema and distichiasis are highly penetrant. Distichiasis without lymphedema is not commonly seen. We examined three generations of a family (N = nine members) with hereditary distichiasis but without lymphedema or other features of LD syndrome. The FOXC2 gene was polymerase chain reaction--amplified from genomic DNA from all family members and examined for mutations. Clinical examination showed distichiasis of all four lids in two affected family members across two generations. There were no other consistent ophthalmologic abnormalities in the family. A cytosine-to-adenine transversion was identified in DNA from affected study participants at nucleotide position 1076, which would be predicted to cause truncation of the protein at codon 359. This change was not observed in any of the nine unaffected family members participating. This finding suggests that hereditary distichiasis and LD may not be separate genetic disorders but different phenotypic expressions of the same underlying disorder. Ophthalmologists should be aware that LD may present as distichiasis alone and counsel and refer their patients appropriately.Journal of American Association for Pediatric Ophthalmology and Strabismus 11/2003; 7(5):354-7. DOI:10.1016/S1091853103001447 · 1.14 Impact Factor
Article: Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas.[Show abstract] [Hide abstract]
ABSTRACT: Genomic amplification can lead to the activation of cellular proto-oncogenes during tumorigenesis, and is observed in most, if not all, human malignancies, including adenocarcinomas of lung and esophagus. Using a two-dimensional restriction landmark genomic scanning technique, we identified five NotI/HinfI fragments with increased genomic dosage in an adenocarcinoma of the gastroesophageal junction. Four of these amplified fragments were matched within three contigs of chromosome 12 using the bioinformatics tool, Virtual Genome Scan. All three of the contigs map to the 12q13-q14 region, and the regional amplification in the tumor was verified using comparative genomic hybridization analysis. The 12q14 amplicon was characterized using sequence tagged site-amplification mapping with DNA from paired normal-tumor tissues of 75 gastroesophageal and 37 lung adenocarcinomas. The amplicon spans a region of >12 Mb between genes DGKA and BLOV1. The core-amplified domain was determined to be <0.5 Mb between marker WI-12457 and gene IFNG. However, MDM2, a well-documented oncogene of the region, is outside the core-domain. Eleven genes and expressed sequence tags within the amplicon were selected for quantitative reverse transcription-PCR, and DYRK2, a member of the dual-specificity kinase family, was overexpressed in all of the tumors showing gene amplification. Among the sequence tagged site/expressed sequence tag/gene markers tested, DYRK2 demonstrated the highest DNA copy number and the highest level of mRNA overexpression in the tumors. Moreover, DYRK2 mRNA overexpression (>2.5-fold of normal mean) was found in 18.6% of additional 86 lung adenocarcinomas in an assay using oligonucleotide microarrays. DYRK2 mRNA overexpression occurs more frequently than gene amplification in both esophageal and lung adenocarcinomas. This is the first report of amplification and overexpression of DYRK2 in any tumor type.Cancer Research 07/2003; 63(14):4136-43. · 9.28 Impact Factor
Article: FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.[Show abstract] [Hide abstract]
ABSTRACT: Lymphedema-distichiasis (LD) (OMIM 153400) is a rare autosomal-dominant condition characterized by pubertal onset of lower limb lymphedema and an aberrant second row of eyelashes arising from the meibomian glands. In some patients cardiac, skeletal and other defects coexist. We previously identified inactivating, nonsense and frameshift mutations in the forkhead transcription factor FOXC2 in affected members of LD families. To further delineate the relationship of FOXC2 deficiency to the clinical (and lymphangiodysplastic) phenotype in this syndrome, we performed dynamic lymphatic imaging and immunohistochemical examination of lymphatic tissues in mice heterozygous (+/-) for a targeted disruption of Foxc2. Adult heterozygote mice characteristically exhibited a generalized lymphatic vessel and lymph node hyper plasia and rarely exhibited hindlimb swelling. Retrograde lymph flow through apparently incompetent interlymphangion valves into the mesenteric nodes, intestinal wall and liver was also observed. In addition, Foxc2 +/- mice uniformly displayed distichiasis. We conclude that Foxc2 haploinsufficient mice mimic closely the distinctive lymphatic and ocular phenotype of LD patients. Furthermore, the craniofacial, cardiovascular and skeletal abnormalities sometimes associated with LD have previously been shown to be fully penetrant in homozygous Foxc2 null mice. This Foxc2 mutant mouse thus provides an ideal model for exploring molecular mechanisms and physiologic events in mesenchymal differentiation associated with lymphatic growth and development and the clinical abnormalities seen in human LD syndrome.Human Molecular Genetics 06/2003; 12(10):1179-85. · 6.68 Impact Factor
Article: The Hepatocyte Nuclear Factor 3 α Gene, HNF3α (FOXA1), on Chromosome Band 14q13 Is Amplified and Overexpressed in Esophageal and Lung Adenocarcinomas[Show abstract] [Hide abstract]
ABSTRACT: Genomic amplification is observed in many, if not all, types of human malignancy and is one of the mechanisms for the activation of dominant-acting oncogenes in tumorigenesis. In the present study, three amplified restriction fragments were identified in an esophageal adenocarcinoma (P16) using the restriction landmark genome scanning two-dimensional gel technique. These fragments were cloned, sequenced, and mapped to chromosome band 14q13. Using the sequence tagged site-amplification mapping approach, we defined the core-amplified domain by screening 75 normal-tumor paired esophageal samples. The frequency of 14q13 amplification is 6.7% in esophageal tumors, and the amplicon spans >6 Mb in 1 tumor but is contained in a region <0.3 Mb in all of the remaining amplified tumors. Quantitative reverse transcription-PCR (RT-PCR) of 8 genes and expressed sequence tags located within the core-amplified domain revealed that the HNF3alpha (FOXA1)(4) gene, a forkhead gene family member, was overexpressed in all of the amplified esophageal tumors. HNF3alpha amplification was confirmed by Southern blot and interphase fluorescence in situ hybridization analyses, and the results of real-time RT-PCR were consistent with that of the regular quantitative RT-PCR. Increased immunohistochemical nuclear staining of the HNF3alpha protein was detected in all of the tumors containing 14q13 amplification. Affymetrix oligonucleotide microarrays of 86 lung adenocarcinomas demonstrated that expression of the HNF3alpha mRNA was elevated (> or =2.5-fold of mean expression in normal lung) in 37% (32 of 86) of the tumors analyzed. Gene amplification of HNF3alpha was detected in 2 of the 5 overexpressed lung tumors examined. This is the first report of HNF3alpha amplification, and overexpression in esophageal and lung adenocarcinomas. Amplification of HNF3alpha in esophageal and lung tumors may suggest a potential oncogenic role for this gene in tumorigenesis.Cancer Research 09/2002; 62(18):5273-9. · 9.28 Impact Factor
Article: Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development[Show abstract] [Hide abstract]
ABSTRACT: The human ATOH7 gene encodes a basic helix-loop-helix (bHLH) transcription factor that is highly similar to Drosophila Atonal within the conserved bHLH domain. The ATOH7 coding region is contained within a single exon. We mapped ATOH7 to Chromosome (Chr) 10q21.3-22.1, a region syntenic to the segment of mouse Chr 10 where Atoh7 (formerly Math5) is located. The evolutionary relationship between ATOH7 and other atonal homologs was investigated using parsimony analysis. A direct comparison of ATH5/7 and ATH1 protein subgroups to Atonal also revealed a nonrandom distribution of amino acid changes across the bHLH domain, which may be related to their separate visual and proprioceptive sensory functions. Among bHLH genes, ATOH7 is most closely related to Atoh7. This sequence conservation extends significantly beyond the coding region. We define blocks of strong homology in flanking human and mouse genomic DNA, which are likely to include cis regulatory elements. Because targeted deletion of Atoh7 causes optic nerve agenesis in mice, we propose ATOH7 as a candidate for human optic nerve aplasia and related clinical syndromes.Mammalian Genome 03/2002; 13(2):95-101. DOI:10.1007/s00335-001-2101-3 · 2.88 Impact Factor
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ABSTRACT: Hereditary lymphoedema-distichiasis (LD) is an autosomal dominant disorder that classically presents as lymphoedema of the limbs, with variable age of onset, and extra aberrant growth of eyelashes from the Meibomian gland (distichiasis). Other major reported complications include cardiac defects, cleft palate, and extradural cysts. Photophobia, exotropia, ptosis, congenital ectropion, and congenital cataracts are additional eye findings. Recently, we reported that truncating mutations in the forkhead transcription family member FOXC2 resulted in LD in two families. The clinical findings in seven additional families with LD, including the original family described by Falls and Kertesz, were determined and mutational analyses were performed. Distichiasis was the most common clinical feature followed by age dependent lymphoedema. There is a wide variation of associated secondary features including tetralogy of Fallot and cleft palate. The mutational analyses identified truncating mutations in all of the families studied (two nonsense, one deletion, three insertion, and one insertion-deletion), which most likely result in haploinsufficiency of FOXC2. FOXC2 mutations are highly penetrant with variable expressivity which is not explicable by the pattern of mutations.Journal of Medical Genetics 12/2001; 38(11):761-6. · 5.64 Impact Factor
Article: A Novel Frameshift Mutation in Exon 23 of ATP7A (MNK) Results in Occipital Horn Syndrome and Not in Menkes Disease[Show abstract] [Hide abstract]
ABSTRACT: Menkes disease and occipital horn syndrome (OHS) are allelic, X-linked recessive copper-deficiency disorders resulting from mutations in ATP7A, or MNK. Classic Menkes disease has a severe phenotype, with death in early childhood, whereas OHS has a milder phenotype, with, mainly, connective-tissue abnormalities. Data suggest that steady-state localization of ATP7A to the trans-Golgi network (TGN) is necessary for proper activity of lysyl oxidase, which is the predominant cuproenzyme whose activity is deficient in OHS and which is essential for maintenance of connective-tissue integrity. Recently, it was reported that ATP7A-transcript levels as low as 2%-5% of normal are sufficient to result in the milder phenotype, OHS, rather than the phenotype of Menkes disease. In contrast to previously reported cases of OHS, we describe a case of OHS in which, because of a frameshift mutation, no normal ATP7A is produced. Although abundant levels of mutant transcript are present, there are substantially reduced levels of the truncated protein, which lacks the key dileucine motif L1487L1488. It has been demonstrated that the dileucine motif L1487L1488 functions as an endocytic signal for ATP7A cycling between the TGN and the plasma membrane. The present report is the first to describe an ATP7A truncation that results in OHS rather than in Menkes disease. The data from the present report support the concepts that (1) OHS results from lower levels of functional ATP7A and (2) ATP7A does not require the dileucine motif to function in copper efflux.The American Journal of Human Genetics 09/2001; 69(2):420-7. DOI:10.1086/321290 · 10.99 Impact Factor
Article: Translocation breakpoints in FHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinoma.[Show abstract] [Hide abstract]
ABSTRACT: Common fragile sites have been proposed to play a mechanistic role in chromosome translocations and other rearrangements in cancer cells in vivo based on their behavior in vitro and their co-localization with cancer translocation breakpoints. This hypothesis has been the subject of controversy, because associations have been made at the chromosomal level and because of the large number of both fragile sites and cancer chromosome breakpoints. Tests of this hypothesis at the molecular level are now possible with the cloning of common fragile site loci and the use of fragile site clones in the analysis of rearranged chromosomes. FRA3B, the most frequently seen common fragile site, lies within the large FHIT gene. It is now well established that this region is the site of frequent, large intragenic deletions and aberrant transcripts in a number of tumors and tumor cell lines. In contrast, only one tumor-associated translocation involving the FHIT gene has been reported. We have found translocations in both homologs of chromosome 3 in an early-passage esophageal adenocarcinoma cell line. This cell line showed no normal FHIT transcripts by reverse transcription polymerase chain reaction. Subsequent chromosome analysis showed translocations of the short arms of both homologs of chromosome 3: t(3;16) and t(3;4). The breakpoints of both translocations were shown by fluorescence in situ hybridization and polymerase chain reaction to be in the FHIT gene, at or near the center of the fragile site region. Using rapid amplification of cDNA ends with FHIT primers, a noncoding chimeric transcript resulting from t(3;16) was identified. These data provide direct support for the hypothesis that FRA3B, and likely other common fragile sites, may be "hot spots" for translocations in certain cancers, as they are for deletions, and that such translocations have the potential to form abnormal chimeric transcripts. In addition, the results suggest selection for loss of a functional FHIT gene by the translocation events.Genes Chromosomes and Cancer 04/2001; 30(3):292-8. · 3.84 Impact Factor
Article: Translocation breakpoints inFHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinomaGenes Chromosomes and Cancer 03/2001; 30(3):292-298. DOI:10.1002/1098-2264(2000)9999:9999<::AID-GCC1095>3.0.CO;2-F · 3.84 Impact Factor
Article: Mutations in FOXC2 (MFH-1), a Forkhead Family Transcription Factor, Are Responsible for the Hereditary Lymphedema-Distichiasis Syndrome[Show abstract] [Hide abstract]
ABSTRACT: Lymphedema-distichiasis (LD) is an autosomal dominant disorder that classically presents as lymphedema of the limbs, with variable age at onset, and double rows of eyelashes (distichiasis). Other complications may include cardiac defects, cleft palate, extradural cysts, and photophobia, suggesting a defect in a gene with pleiotrophic effects acting during development. We previously reported neonatal lymphedema, similar to that in Turner syndrome, associated with a t(Y;16)(q12;q24.3) translocation. A candidate gene was not found on the Y chromosome, and we directed our efforts toward the chromosome 16 breakpoint. Subsequently, a gene for LD was mapped, by linkage studies, to a 16-cM region at 16q24.3. By FISH, we determined that the translocation breakpoint was within this critical region and further narrowed the breakpoint to a 20-kb interval. Because the translocation did not appear to interrupt a gene, we considered candidate genes in the immediate region that might be inactivated by position effect. In two additional unrelated families with LD, we identified inactivating mutations-a nonsense mutation and a frameshift mutation-in the FOXC2 (MFH-1) gene. FOXC2 is a member of the forkhead/winged-helix family of transcription factors, whose members are involved in diverse developmental pathways. FOXC2 knockout mice display cardiovascular, craniofacial, and vertebral abnormalities similar to those seen in LD syndrome. Our findings show that FOXC2 haploinsufficiency results in LD. FOXC2 represents the second known gene to result in hereditary lymphedema, and LD is only the second hereditary disorder known to be caused by a mutation in a forkhead-family gene.The American Journal of Human Genetics 01/2001; 67(6):1382-8. DOI:10.1086/316915 · 10.99 Impact Factor
Article: Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant[Show abstract] [Hide abstract]
ABSTRACT: A polymerase chain reaction (PCR)-based strategy was used to isolate a mouse cDNA (mCtr1) encoding a Cu transport protein. The deduced mCtr1 protein sequence exhibits 92% identity to human Ctr1, and has structural features in common with known high affinity Cu transporters from yeast. The expression of mouse Ctr1 functionally complements baker's yeast cells defective in high affinity Cu transport. Characterization of the mCtr1 genomic clone showed that the mCtr1 coding sequence is encompassed within four exons and that the mCtr1 locus maps to chromosome band 4C1-2. RNA blotting analysis demonstrated that mCtr1 is ubiquitously expressed, with high levels in liver and kidney, and early in embryonic development. Steady state mammalian Ctr1 mRNA levels were not changed in response to cellular Cu availability, which is distinct from the highly Cu-regulated transcription of genes encoding yeast high affinity Cu transporters. These studies provide fundamental information for further investigations on the function and regulation of Ctr1 in Cu acquisition in mammals.Gene 09/2000; 254(1-2):87-96. DOI:10.1016/S0378-1119(00)00287-0 · 2.08 Impact Factor
Article: The canine copper toxicosis locus is not syntenic with ATP7B or ATX1 and maps to a region showing homology to human 2p21.[Show abstract] [Hide abstract]
ABSTRACT: Peer Reviewed http://deepblue.lib.umich.edu/bitstream/2027.42/42119/1/335-10-7-753_10n7p753.pdfMammalian Genome 08/1999; 10(7):753-6. · 2.88 Impact Factor
Article: The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region.[Show abstract] [Hide abstract]
ABSTRACT: The human FHIT gene is a putative tumor suppressor gene that maps to human chromosome band 3p14.2 in a region that is frequently deleted in cancers. It exhibits both genomic deletions and aberrant transcripts in a variety of tumors and spans the common fragile site FRA3B. This fragile site extends over a broad region of several hundred kb within the FHIT gene and may account for its instability in tumors. As one test of this hypothesis, we isolated the murine Fhit gene and asked whether it also contains a common fragile site and if it is unstable in mouse tumors or tumor cell lines. The Fhit gene was isolated, and the sequence was found to be 87.5% identical to that of the human FHIT gene in the open reading frame. Using fluorescence in situ hybridization, Fhit was assigned to mouse chromosome band 14A2, in a region that was previously shown to contain an aphidicolin-inducible mouse fragile site. Fluorescence in situ hybridization with genomic clones containing Fhit and flanking sequences demonstrated that gaps and breaks in the fragile site occur over a broad region within and proximal to the Fhit locus. Thus, the physical relationship of Fhit to a common fragile site is similar to that observed with the orthologous human FHIT gene and FRA3B.Cancer Research 09/1998; 58(15):3409-14. · 9.28 Impact Factor
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Concordia University–Ann ArborAnn Arbor, Michigan, United States
University of Michigan
Ann Arbor, MI, United States
- • Department of Human Genetics
- • Division of Pediatric Genetics
The University of ArizonaTucson, Arizona, United States


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Swine Lake
By James Marshall; Maurice Sendak (Illustrator)
(HarperCollins Publishers, Hardcover, 9780062051714, 40pp.)
Publication Date: April 1999
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When a lean and mangy wolf stumbles into the Boarshoi Ballet, he finds tasty pigs a-plenty, twirling and whirling in a performance of Swine Lake. Faced with all those luscious porkers, whats a hungry wolf to do? Well, something totally surprising, as it turns out.
Pure fun from Marshall and Sendak--an incomparable duo!
About the AuthorJames Marshall (1942-1992) is one of the most popular and celebrated artists in the field of children"s literature. Three of his books were selected as New York Times Best Illustrated Books, and he received a Caldecott Honor Award in 1989 for Goldilocks and the Three Bears. With more than seventy-five books to his credit, including the popular George and Martha series, Marshall has earned the admiration and love of countless readers.
Maurice Sendak (1928-2012) was the author and illustrator of such classic children's books as "Where the Wild Things Are" and "In the Night Kitchen". Widely considered one of the most innovative creators of children's literature, he received honors including the Caldecott Medal, the Hans Christian Andersen Medal, the Laura Ingalls Wilder Award, and the National Medal of Arts. Sendak was born in Brooklyn in 1928 and died in Connecticut in 2012.

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1990 Nissan Pickup (D21) Q&A
1990 Nissan Pickup (D21) Question: parking brake
I have a 1990 nissan hardbody pickup (D21) that the parking brake cable? has either broken or disengaged from the parking brake handle. Is this an easy fix? - skim711
Answer 1
Easy fix no, you need to get under the car and you need some tools to make the job easier on you. - sinautoscan.com
Answer 2
Not only do you need to get under the vehicle, you have to pull up the carpeting and such under the pedals. The cable goes straight down the firewall and through the floor rather than through the firewall into the engine compartment. One tip, you don't have to take out the handle to get the cable out of it. You just need to get the cable at the right angle and it pops out of the handle. - Visitor
Answer 3
I have a 92 Nissan KC. At present i'm replacing the xmissin so the xmission and xfer is out. in the past my PB wouldn't work correctly. It seemed that one of my cables was stretched so I replaced the entire cabling from the adjustment under the cab all the way back to both wheels. This still didn't fix my PB. Is this similar to what you are experienceing? Now that I am able to get at everything I am taking the task of find what the problem is. write me at firstname.lastname@example.com if what I find is of any value. Put in the subject Parking Brake so I know not to delet you... David - desert_knight
Answer 4
it depends what parking brake handle you have, if it is in between the seats it is an easy fix - Visitor
Answer 5
It depends on the circumstances. For instance, I had the exact same thing happen to me and after some investigation I noticed the cable didn't break, it just came out from the branke handle. If the cable is in tact and the end of the cable has a silver ball on it, you are in luck. Right where it goes through the floor is where it might be sitting. If this is the case, loossen the cable from underneath the truck (adjustment is between cab and rear brak area (easy to get to) and grab the ball. Pull the brake handle up and you'll see a large slot at the top. That is where you drop the "ball" in. Push the brake handle back in to its normal driving position and drop the ball in the hole at the top of the handle. TIghten the cable adjustment under the truck and you're good to go. - Visitor
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Kenny Rogers sues Capitol Records over royalties
Published: Tuesday, February 14, 2012 at 2:01 p.m.
Last Modified: Tuesday, February 14, 2012 at 2:01 p.m.
NASHVILLE, Tenn. — Kenny Rogers is suing Capitol Records, claiming the company has not properly paid him for digital downloads, ringtones and other uses of his songs.
Rogers filed the lawsuit on Monday in federal court in Nashville.
He seeks a declaration that under his contract he is owed 50 percent of net royalties for the licensing of his master recordings to third-parties like iTunes and Verizon Wireless.
The suit states that Rogers began an audit of Capitol's books in 2007 and was in settlement negotiations with the company for about three years.
Rogers claims the company owes him at least $400,000, although he does not know the total amount because Capitol has withheld some financial records.
Capitol did not immediately return a call seeking comment.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Hypoplastic Left Heart Syndrome
DefinitionHypoplastic left heart syndrome is a rare heart defect. In a normal heart, the blood flows in from the body to the right atrium. It then goes into the right ventricle. Next, the blood travels to the lungs through the pulmonary valve. Here, it picks up fresh oxygen. The blood returns to the left atrium and goes into the left ventricle. The blood then moves out to the rest of the body.With this syndrome, structures on the left side of the heart, which includes the aorta, aortic valve, left ventricle, and mitral valve, may be:
- Too small
- Absent
- Abnormally developed
|Heart Chambers and Valves
|Copyright © Nucleus Medical Media, Inc.
|Blood Flow Through the Heart
|Copyright © Nucleus Medical Media, Inc.
CausesHypoplastic left heart syndrome is present at birth. It is not known exactly why the heart does not develop normally.
Risk FactorsThese factors increase your chance of having a child with hypoplastic left heart syndrome:
- Previous pregnancy with fetal heart abnormalities or fetal loss
- Family history of congenital heart defects
SymptomsSymptoms usually appear within days after birth. Tell the doctor if you notice the following in your infant or child:
- Blue/gray skin color
- Cool skin
- Rapid or difficult breathing
- High heart rate
- Sweaty, clammy skin
- Poor feeding
More from Beliefnet
Current Research From Top Journals
Chewing Gum After Surgery May Improve Digestive Tract Recovery
Early Peanut Consumption Associated with Lower Risk of Peanut Allergy in High Risk Children
Breastfeeding May Decrease the Risk of Childhood Obesity
Tonsillectomy May Reduce Number of Sore Throat Days in Children
April 2015
A systematic review found that participants given chewing gum after abdominal surgery may have a faster return to normal for their digestive system. Unfortunately, the quality of trials is low and more research will need to be done before this simple solution is confirmed.
previous editions
Early Peanut Consumption Associated with Lower Risk of Peanut Allergy in High Risk Children
March 2015
Breastfeeding May Decrease the Risk of Childhood Obesity
February 2015
Tonsillectomy May Reduce Number of Sore Throat Days in Children
February 2015


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VIEWS: 150 PAGES: 6 CATEGORY: Business POSTED ON: 9/20/2009 Public Domain
Sample Invitation & Agenda for Organizational Meeting #1 Greetings, all… In preparation for the first GSA World Service Conference in August 2010, the GSAWS Board is organizing GSers worldwide into intergroups. Each intergroup will elect a delegate to send to the Conference. That's why I'm writing today. We are now forming the intergroup for the Southeastern U.S. and want the GSR from your meeting to attend the Southeastern U.S. intergroup's organizational meeting. You are receiving this email because you are listed as either the secretary or the GSR for your group on the Greysheeters Anonymous website. If you are not the GSR for your group, please forward this email to the right person. Our organizational meeting will be conducted via teleconference from 7 – 8 pm EDT on Monday, April 27, 2009. Here's the call-in information: Phone number: 219.509.8020 Access code: 982001# During the meeting, we will: 1. Discuss the role of the intergroup and how it fits into the proposed service structure of GSA 2. Discuss leadership roles within the intergroup, including the role of the conference delegate 3. Discuss the group's preferences for selecting a conference delegate Please let me know whether you will be able to attend. In service… Sample Follow-Up Email after Organizational Meeting #1 Greetings, all… Thank you for attending our very first meeting of the SE Intergroup. Below are some quick answers to a few of the job duty and abstinence requirement questions that came up this evening. This is from the GS website. All guidelines are suggested until approved by the first World Service Conference. More to come… In service… Area Delegate (AD) B2B Abstinence Requirement: 3 yrs Term of service: 2 yrs Duties: Represents the Group at a higher level of the service structure. An AD represents only one Intergroup of GSA. An AD is usually a GSR but this is not a requirement. Attends Area Intergroup meetings to learn more about issues concerning their Area so they may represent their Area at the World Service Conference. Receives information from the Board of Trustees of GSA World Service and shares that information with their Intergroup. General Service Representative (GSR) B2B Abstinence Requirement: 1 yr Term of service: 1 yr Duties: Represents the Group at a higher level of the service structure, typically an Intergroup or Area; Conducts Group Conscience Meetings as needed, typically once a month; Ensures our Primary Purpose is carried out when facilitating a Group Conscience; Cannot represent more than one group as GSR. Sample Minutes from Organizational Meeting #1 Greetings, all… Here is a brief recap of the organizational meeting of the Southeastern Intergroup of GSA. We met at 7 pm EDT on Monday, April 27, 2009 via phone bridge. Attending: GSR 1 GSR 2 GSR 3 GSR 4 Topics Discussed: [INTERGROUP ORGANZER] reviewed the role of the intergroup and how it fits into the emerging service structure of GSA, the roles of leadership roles within the intergroup, including the role of the WS Conference delegate. [INTERGROUP ORGANZER] will email the group more information about the criteria for serving as GSR and delegates. We discussed reaching out to people who are leading meetings in other parts of the Southeast who didn't participate in tonight's call. GSR 1 will touch base with them via email to see if they are interested in participating. [INTERGROUP ORGANZER] talked about next steps in the formation of an intergroup, including electing officers (Chair/Delegate; Vice-Chair/Secondary Delegate, Secretary). We decided to postpone the selection of a Delegate until at least the next meeting. We agreed on a date/time for our next meeting, which will be Tuesday, May 5 at 7:45 p.m. EDT. [INTERGROUP ORGANZER] will schedule the phone bridge and let everyone know the call-in instructions. The meeting closed with the Serenity Prayer. Sample Invitation & Agenda for Organizational Meeting #2 Greetings, all… Below is the agenda for the second organizational meeting of the Southeastern U.S. GSA Intergroup, which is set for this coming Tuesday, May 5, 2009 at 7:45 p.m. EDT. Dial: 219-509-8020 Access Code: 982001# Plan on an hour. Please forward this to anyone in your area who might be interested in listening in… Open with Serenity Prayer Take attendance and recognize newcomers/observers Review meeting objectives Discuss and agree on the possibilities for scope of work for our intergroup Review roles, responsibilities and abstinence requirements for delegate, alternate delegate and intergroup secretary Elect Delegate/Secondary Delegate/Secretary Set date/time for next meeting Close with the serenity prayer I am hoping that we will have representation from most of the meetings in our region (Southeastern U.S. and Caribbean) so we can have a full participation in the discussion about what we want our intergroup to be/do, as well as a good assortment of candidates to choose from for elected positions, which will include the Area Delegate, who represents our area at the WS conference and chairs intergroup meetings, Alternate Delegate, who fulfills the Delegates duties in his/her absence, and the Secretary, who schedules meetings and records the minutes. Anyone who attends your meetings or outposts you know of in the region we represent can listen in. Before the meeting, it may be helpful for you to know more about how the GSAWS Board sees intergroups operating in GSA. The GSA World Service Board has put together some proposed guidelines for intergroup service. Find them here: http://www.greysheet.org/intergroupareaguidelines.shtml. Note that these guidelines are not official and won't be until after delegates vote to approve them in this or some other form at the first world service conference in 2010. If you are familiar with AA service, you will notice that GSA intergroups are serving as both the coordinator of outreach services to a geographical region (the traditional intergroup role in AA and OA) and as the conduit for representation of individual group preferences up the channels to the world service conference (handled in the assembly process in AA and OA). Any questions? Call me or email me! In service… Sample Minutes from Organizational Meeting #2 Below are the minutes for the May 5, 2009 organizational meeting of the GSA Southeastern Region Intergroup, which met from 7:45 p.m. to 8:30 p.m. EDT on Tuesday, May 5, 2009. Call to Order: [INTERGROUP ORGANZER] called the meeting to order with the Serenity Prayer. Attendance: GSR 1, GSR 2, GSR 3, GSR 4, GSR 5 Intergroup Scope of Work: Deciding what we want our intergroup to do is an important start-up task. [INTERGROUP ORGANZER] reviewed the GSAWS Board suggestions about what intergroups might do. This document is at http://www.greysheet.org/intergroupareaguidelines.shtml. Note that these guidelines are not official and won't be until after delegates vote to approve them in this or some other form at the first world service conference in 2010. After discussion, we agreed that since our GSA groups are spread throughout a very large region, it would be difficult to do coordinated outreach. An intergroup performing the following functions might be right for us: 1. Serve as the conduit for information flow to/from each group to the WS Conference 2. Share best practices about how to launch and grow a GSA community and how to carry the message to our communities 3. Develop a region-wide phone list that includes GSA member name, phone, email, abstinence date and best time to call, which would help build a sense of community in our region 4. In the future, sponsor or co-sponsor a regional retreat We discussed the idea of having quarterly phone meetings, with an agenda that would feature the usual committee reports (Secretary/Treasurer/PI, if applicable) plus reports from the Area Delegate about activities at the World Service level, best practice discussions and updates/refinements to the phone list. GSRs not able to participate in tonight's call are invited to submit their feedback on this suggestion to the entire group (use REPLY ALL to this email). We will revisit this issue at our next meeting and (hopefully) have enough people participating in the call so we can vote. Service Positions: We need to elect an Area Delegate, who attends the WS Conference and Chairs the intergroup meetings; and Alternate Delegate, who chairs the intergroup meetings in the Delegate's absence and attends the WS Conference if the Primary Delegate cannot; and a Secretary, who records the minutes. We also discussed the duties and abstinence requirements for the various service positions (Area Delegate = 3 years b2b; GSR = 1 year b2b). [INTERGROUP ORGANZER] cannot be the area delegate because she already has a vote at the WS Conference as a Trustee on the GSAWS Board. We agreed to table the discussion of officers and the election until the next meeting. Next Meeting: 7:45 p.m. EDT on Tuesday, June 2, 2009 via phone bridge. [INTERGROUP ORGANZER] will schedule the bridge and email the call-in info to all. Close: [INTERGROUP ORGANZER] closed the meeting with the Serenity Prayer. Sample Minutes from Organizational Meeting #3 Below are the minutes for the June 2, 2009 meeting of the GSA Southeastern Region Intergroup, which met from 7:45 p.m. to 8:00 p.m. EDT on Tuesday, June 2, 2009. Call to Order: [INTERGROUP ORGANIZER] called the meeting to order with the Serenity Prayer. Attendance: GSR 1, GSR 2, GSR 3, GSR 4, GSR 5 Election of Officers: We agreed to assume the following leadership roles: Intergroup Chair/Area Delegate: [NAME] Intergroup Vice Chair/Alternate Delegate: [NAME]. Secretary: [NAME] Next Meeting: TBD Close: [INTERGROUP ORGANIZER] closed the meeting with the Serenity Prayer.
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Playoffs Panel: How did a 0-2 hole turn into a 3-2 lead?
It wasn't that long ago that folks in Memphis were thinking about writing the Grizzlies off. Then came three straight wins and the chance to close out the Clippers Friday night at FedExForum.
So we asked our Playoffs Panel members this:
Hard as it is to imagine right now, the Grizzlies were actually down 0-2 in this series. (Remember?) So what has been the most important factor in the turnaround to be up 3-2?
Brian Boone, Griz fan: "Since the second half of Game 2, the Grizzlies' frontcourt has simply dominated the Clippers'! Marc Gasol, Zach Randolph and company have taken control of the boards, scored more second chance points, shot efficiently, and played stifling defense. I look for more of the same on Friday at the Grindhouse."
Pat Brown, Griz fan: "The Griz got their focus back during Game 2. Since then, they have had a laser lock on forcing their game on the Clippers. Plus, Lionel Hollins' strategy with rotating defenses on Chris Paul has kept him contained. When the Griz keep their mental focus on Grit and Grind, they win."
Geoff Calkins, CA columnist: "You limit us to 50 words in these answers, right? I just need three: Marc, Mike, Z-Bo."
Peter Edmiston, WHBQ host and CA's Numbers Game analyst: "Grizzlies' aggressiveness. Asserting themselves physically and controlling the tempo and style of the games. That starts inside with Randolph and Gasol but would be almost impossible without the superb play of Mike Conley."
Katee Forbis, Griz fan: "I think the most important factor has been the Grizzlies competitive drive. Marc Gasol has said that he thinks he may hate losing more than he loves winning. I think that is probably true of the Memphis Grizzlies as a whole as well. Much like the city of Memphis, the Grizzlies refuse to assume the role of lovable losers."
Ron Higgins, CA reporter: "Gasol and Randolph adjusted to officiating, and Hollins tightened his rotation."
Cameron Kitchin, Griz fan: "The team has been talking since Game 2 about the importance of offensive pace — bringing the ball up court quickly and penetrating the Clippers' defensive rotations. I agree. The key in Game 6 will continue to be how fast the ball can get into Randolph and Gasol's hands down low."
Brevin Knight, Griz TV analyst: "The biggest differences are intensity, attention to detail and executing the game plan on both ends. They have dominated the boards, second chance points, and paint scores. Another big factor has been Eric Bledsoe's ineffectiveness since Game 1. If the bigs dominate Game 6, second round here we come. Go Grizz!!"
Chase Lucas, Griz fan: "Z-Bo. There are dozens of factors that all play off one another but none of this happens if Zach Randolph doesn't find whatever it is he found."
Brett Moore, Griz fan: "Lionel Hollins' defensive adjustments have been the biggest difference in the series. Otherwise, taking over the paint, Tayshaun Prince gaining confidence on offense and Conley's stellar play have also contributed to the three straight victories."
Marlon W. Morgan, CA reporter: "The most important factor is that Marc and Zach are playing well simultaneously. Most of this season, it was one or the other playing well. But when they're both on, the Grizzlies are a hard team to defend, especially with Conley stepping his game up, too."
Nick Rahme, Griz fan: "It has to be Zach Randolph. To be successful in the NBA today you have to have more than one superstar. Zach has played like a superstar in the last three games along with Marc Gasol. That duo along with a solid Conley are difference makers."
Kevin Ritz, Griz fan: "The turning point was January 30, when the team traded Rudy Gay. These playoff wins neatly demonstrate the effectiveness of an offense centered on Gasol, Conley, and Z-Bo — our three best players before and after the trade. We're now on the verge of our second playoff run — both without Rudy."
Ronald Tillery, CA Griz beat reporter: "The Grizzlies' defense is doing major damage. The Clippers entered the series as one of the most efficient and high-scoring offenses in the NBA at 101.1 points per game. Since allowing 112 points in Game 1, the Griz have essentially held the Clippers in the mid-80s on average. Chris Paul is the only weapon firing consistently for the Clippers on the perimeter."
William Terrell, Griz fan: "As Peter Edmiston put it in his CA piece today, the Clippers have no answer for Z-Bo Playoff Edition 2013. The Grizzlies' version of the "Big Three" have consistently outplayed whoever you consider the Clippers best three players since Game Two. Kudos to Hollins for shortening the rotation and going with the guys that brought us here. Go Grizz!
Drew Tucker, Griz fan: "Confidence and Tayshaun. Those are really the only factors that have significantly changed. I want to caution all Grizz fans to take the series one game at a time. Too much looking ahead. Still believe Grizzlies in 6."
Austin Webster, Griz fan: "The starting frontcourt of Randolph and Gasol has been the most important factor in the series turnaround. One by one, they are offensively schooling the Clippers' big men. And defensively, they are slowing the whole team down and not allowing them to fly around the basket for easy dunks/putbacks."
David Williams, CA sports editor: They got back to playing Grizzlies-style ball, and then — in the case of guys like Randolph, Conley and Gasol — turned it up a few notches.
Dan Woike, Clippers beat reporter, Orange County Register: "Memphis has been able to impose its style on the Clippers, and for whatever reason, Los Angeles seems content to play at that style. Grizzlies have also been getting contributions from six guys a night, while Clippers' non-stars have struggled to make shots."
Paul Young, Griz fan: "Grizzlies are dialed in on defense and it's disrupted the flow and confidence of the Clippers. CP3 has had big games, but the more he scores the less involved the rest of his team is. This has allowed the Grizz to keep the role players subdued. Big offensive production from the Grizz big men has the Clips clamoring for answers."
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The city of Camden recently received a $45,000 grant from South Carolina State Law Enforcement Division (SLED), and a $64,121 grant from the S.C. Department of Public Safety that will be used to purchase upgraded radio equipment for city public safety personnel.
Camden City Councilman Patrick D. "Pat" Partin will not run for reelection this fall. Partin made the decision official during an interview Thursday morning.
Camden City Council will consider at its meeting Tuesday evening first reading of an amendment to the city's sign ordinance, specifically a section concerning freestanding signs. If passed on second reading at a subsequent meeting, the ordinance would replace Section 157.069(A)(1) with the following language:
Imagine being a little boy growing up at the Hobkirk Inn when its formal gardens, designed by Scottish landscape architect James Crammond, were in their prime. The garden was laid out in a large rectangle with wide paths to run down and nooks and crannies in which to play hide and seek. Tall cherry laurel, or mock orange, arches framed the entrances to the parterre garden and beyond them lay the wide open land and woodlands of the Hobkirk Inn, which encompassed 34.75 acres in its early years. Inman wrote in his autobiography, penned at the Biltmore Forest School ...
Camden City Council voted 4-1 Tuesday to amend recommendations made by the Camden Local Tax Fund Committee (CLTFC) in order to continue supporting efforts to obtain U.S. National Park Service (NPS) status for the Battle of Camden site. The battle site is some eight miles north of the city limits on Flat Rock Road. The Palmetto Conservation Foundation (PCF) continues to make improvements at the site and is part of a consortium of groups working with federal officials to obtain the NPS designation.
The Camden Local Tax Fund Committee (CLTFC) will make its first-ever recommendations Tuesday on how Camden City Council should allocate $95,000 to tourism-related organizations. The CLTFC received requests totaling $164,317, nearly $70,000 more than which the committee had to work.
Melanee Harwell-Taylor's special needs class at Camden Elementary School won the 2012 Margot Rochester Landscape Award. Camden Elementary School's Puzzles in Bloom serves as a sensory garden for the special needs class. The award is named after the late Kershaw County gardener and writer Margot Rochester. The award recognizes landscapes, within Camden city limits, that contribute to the beauty of the city. The Margot Rochester award is sponsored by the Camden Parks &Trees Commission.
(The online version of this story corrects the date of Camden City Council's next meetings. Both work session and regular meeting will be held on June 12, not June 5 as originally published.)
On April 30, about 30 Camden and Kershaw County elected officials, candidates for office, school district officials, business owners and others traveled to Rock Hill. The goal: learn more about how the former textile town transformed itself into a sports tourism destination.
City of Camden residents visiting the city's website can read and email comments about a proposed ordinance to transform the Camden Historic Landmarks Commission (CHLC) into a Board of Architectural Review (BAR). Camden City Council looked at the proposal and discussed it during a work session Tuesday afternoon ahead of its regular evening meeting.
The distribution of $27,000 in accommodations tax (ATAX) will be considered by Camden City Council at its meeting Tuesday.
On the evening of Feb. 17, 1864, the moon cast a white glow over the waters of the Atlantic Ocean near the mouth of Charleston Harbor. The USS Housatonic, the Union Navy's largest ship at 1,240 tons, lay at anchor in the ocean two and one half miles outside the harbor entrance. The blockade of Charleston was commanded from her position. Through the frigid waters the brave, determined crew of the Confederate submarine H.L. Hunley navigated from Breach Inlet out to sea, moving toward the Housatonic at three knots. By the time the Union lookout on the ...
The recipients of the Community Impact Award, to be given by the Camden Historic Landmarks Commission o at 6:30 p.m. Tuesday in the City Hall Courtroom, are Marty Daniels and Barbara McCarthy for
The award for New Construction within a Local Historic Neighborhood will be given to Albert and Sarah Reed Tuesday when the Camden Historic Landmarks Commission recognizes a historic property and owner for preserving Camden's heritage through historically in-keeping new construction of a structure or structures within a locally designated historic neighborhood.
A woman who once ran for Camden City Council and a Camden woman who plans a return to a pediatric practice will represent the city's interests on the new Kershaw County Capital Projects Sales Commission.
Page 31 of 47
Camden City Council approved first reading of an ordinance to issue public utility bonds not to exceed $7 million during its June 23 meeting.
In many ways, buying a down-at-the-heels, yet iconic old building and coaxing it back to former glory was almost a case of creative pre-destination for Bob Pullum.
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International Studies in Higher Education Series
Series Editors: David Palfreyman, Ted Tapper, Scott L. Thomas
Access and Expansion Post-Massification
Opportunities and Barriers to Further Growth in Higher Education Participation
Series: International Studies in Higher Education
The 21st century has the potential to be the era of universal higher education access: the post-massification century. The growth of knowledge-based service industries and an increased need for technological and social innovations require more education, training, and re-training at the...
To Be Published December 7th 2015 by Routledge
Affirmative Action Matters
Creating opportunities for students around the world
Series: International Studies in Higher Education
Affirmative Action Matters focuses specifically on affirmative action policies in higher education admissions, the sphere that has been the most controversial in many of the nations that have such policies. It brings together distinguished scholars from diverse nations to examine and discuss the...
Published April 4th 2014 by Routledge
Diversity and Inclusion in Higher Education
Emerging perspectives on institutional transformation
Series: International Studies in Higher Education
In addition to many other issues that touch higher education around the world, diversity and equity in higher education is fast becoming a major opportunity and challenge to institutions, countries and regions. The increasing centrality of diversity is fueled in part by changing demographics,...
Published April 24th 2014 by Routledge
International Trends in University Governance.
Autonomy, self-government and the distribution of authority
Series: International Studies in Higher Education
Governance is becoming increasingly important in universities just as it is in the wider world of commerce and banking. Historically, universities were run by their academic communities but as mass higher education has taken root, as university research has become a critical element in national...
Published June 5th 2014 by Routledge
Overcoming Barriers to Student Understanding
Threshold Concepts and Troublesome Knowledge
It has long been a matter of concern to teachers in higher education why certain students 'get stuck' at particular points in the curriculum whilst others grasp concepts with comparative ease. What accounts for this variation in student performance and, more importantly, how can teachers change...
Published March 22nd 2012 by Routledge
The Global Student Experience
An International and Comparative Analysis
Series: International Studies in Higher Education
There are 100 million students in higher education throughout the world today. This collection provides some indication of what are they are learning and of their wider experiences. It also outlines the changing global context of provision for undergraduate students as countries and universities...
Published July 2nd 2014 by Routledge
The Physical University
Contours of space and place in higher education
Series: International Studies in Higher Education
The great universities of the world are to a large extent defined in the public imagination by their physical form: when people think of a university, they usually think of a distinctive place, rather than about say the teaching or the research that might go on there. This is understandable, both...
Published March 18th 2014 by Routledge
Universities and Regional Development
A Critical Assessment of Tensions and Contradictions
Series: International Studies in Higher Education
Universities are under increasing pressure to help promote socio-economic growth in their local communities. However until now, no systematic, critical attention has been paid to the factors and mechanisms that currently make this process so daunting. In Universities and Regional Development,...
Published March 31st 2014 by Routledge
Universities in the Knowledge Economy
Higher education organisation and global change
Series: International Studies in Higher Education
Universities are fundamental to the contemporary knowledge economy. They directly and indirectly support economic growth in both developing and advanced economies. In addition to their traditional teaching and research functions, they often also have important roles in supporting regional...
Published November 28th 2011 by Routledge


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I recently made a pattern that I love and use everywhere. Should be the new linen.
Download it here use it where you want. Share these links please! Comment if you want to see more!
EDIT: I would really like to see where you guys use it. So tweet me!
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My buddy and I found a powerlifting competition for june 12th and were planning to go compete in it.
This will be are first time, so is there anything specific we shold know?
I know most of the basic stuff , like pausing on bench and going below parralel on squat but other than that i dont know much.


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- Letter: AP courses do not replace Running Start
- Cubs bullpen making waves as offense wanes
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- TRRT Online Edition | July 8-14
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Thunder Update: Lowe family looks to sell Thunder pro fastpitch team
By S.C. Zuba
Sports Columnist
After four years of ownership, the Lowe family has decided to sell the Rockford Thunder, leaving the defending Cowles Cup champions looking for a new home or buyer before the start of the 2010 season.
In a press release, former Thunder owner Robert D. Lowe made the following statement: "It comes with a very heavy heart and at a time of positives that our family has decided to put our women's professional fast pitch team up for sale."
Lowe added: "The team had its best year in 2009, and we couldn't be happier with it ending with a much-deserved title for the girls. But we feel now is the right time for a new owner. I want to thank all the great fans, the hard work of General Manager Aaron M. Moore, assistant Dave Desanti, the entire staff and players, and so many other individuals. We would also like to thank the Village of Roscoe and the group at Stateline Youth Athletics for everything they've done to bring the Thunder where they are today."
The Thunder, one of the original teams to form the National Pro Fastpitch league, began playing in 2003 in Houston, Texas. Lowe purchased the Thunder in 2006 while the team was still in Houston, and left the team there for one season before moving it to Rockford in 2007.
The NPF league has taken over the rights to the team and the roster as they wait for a buyer.
"What we know is Bob Lowe no longer owns the team," NPF Commissioner Cheri Kempf said in a telephone interview last Monday from Nashville, Tenn. "The way it would continue (in Roscoe) is if someone from there bought it. But that territory and that roster are both for sale."
According to Kempf, an Atlanta-based group had signed a letter of intent to purchase the team, yet the group failed to meet the deadline to finalize the deal.
As of now, there is a great deal of uncertainty as to who will be operating the Thunder next season, and where they will be doing so. NPF players are scheduled to report to their teams in May. The schedule for the 2010 season has not yet been released.
If the league cannot find a buyer by the start of the season, it will be forced to operate the team itself, which is something the league is hoping to avoid.
Losing the Thunder would be a great loss for all of the Rockford area as the Thunder are the only professional team that calls Rockford home.
Share your thoughts with S.C. Zuba via e-mail at email@example.com.
From the Dec. 16-22, 2009 issue


text: It has been years since we have had the opportunity to eat at Sonny's since there is not one near our home. My daughter had the pulled pork meal and I had the chicken. DELICIOUS as I remember it from years ago. We are actually heading back again today for more. LOVE LOVE LOVE the garlic bread... read more


text: We were here for the entire week our stay was fantastic. Megan, at the front desk, was wonderful. Megan made it her responsibility to ensure our stay was at the highest standards...and it was. The cleaning staff was great and the hotel was very clean. I highly recommend this hotel as a place to experience Anna Maria Island!!!


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The 2015 Academy Awards
Film writer Chris Dashiell looks ahead to the Oscars, and questions whether they do more to help or hamper the way filmmakers approach their craft.
Film writer Chris Dashiell looks ahead to the Oscars, and questions whether they do more to help or hamper the way filmmakers approach their craft.
A student learns to balance family, education, and work with limited income; translating Murakami's stories into English; repose as a way to deal with stress; a bull rider's quest for the Gold Buckle.
A conversation with musician and songwriter Dan Hicks about his colorful career, and coming back to performing after a bout with cancer.
Music and memories with songwriter and performer Dan Hicks; a trip to the Tohono O'odham Nation to learn how recycling can also be redemption; author Johanna Skibsrud discusses her novel "Quartet for the End of Time".
A trio of virtuoso musicians play a traditional Chinese folk melody, perfom at the Confucius Institute's New Year Celebration.
Annual summer trips educate University of Arizona students about the culture, politics and daily life of an isolated island nation.
The composer, arranger, producer and performer presents an evening of his best-known songs as a guest of the Tucson Jazz Festival.
Volunteers unite to help students in danger of dropping out; how the ecological war against buffelgrass is waged; restoring the legend of Vaudeville-era entertainer Sophie Tucker; a look back at the films of Sir Alec Guinness.
A new documentary pays tribute to "The Last of the Red Hot Mamas", an entertainer who blazed trails for women in music, comedy, and business.
Film writer Chris Dashiell chooses his favorite performances from an actor who later became a space hero in a galaxy far, far away.
Laurence Luckinbill's acting career spans from Shakespeare to Star Trek. He visits Tucson this weekend to perform a one-man show about the private side of American President Theodore Roosevelt.
Listen to the sly, bluesy songs of one of Tucson's most in demand musicians
Acclaimed singer talks about new album, embracing the rhythms of New York, and loving a life of music.
Holocaust scholar says there is much to learn from the recovered journal of a French Jewish woman who died in a concentration camp five days before liberation.
Hear about the origin of a punk rock legend, and re-imaging X's music for the next phase of a four-decade career.
Bassist and musical director Ben Jaffe talks about being an ambassador for the New Orleans sound and spirit.
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Wii U console set for Canadian. release on Nov. 18
Nintendo's upcoming Wii U gaming console will start at $300 and go on sale Nov. 18.
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NEW YORK, N.Y.—Nintendo's upcoming Wii U gaming console will start at $300 and go on sale in Canada and the U.S. on Nov. 18, in time for the holidays, the company said Thursday.
A "deluxe" version will sell for $350. It will be black instead of white and include extra features such as more memory, a charging stand and the game Nintendo Land.
Nintendo Co. has been trying to drum up excitement for the Wii U, which is the first major gaming console to launch since 2006. The device has a touch-screen controller called the Wii U GamePad. It also plays games made for the original Wii.
Nintendo said the latest game in its wildly popular Mario franchise, New Super Mario Bros. U, will be available when the new console launches. It will include new ways to play that use the GamePad. It will also offer new challenges for advanced Mario players, such as trying to complete a level without touching the ground. Mario and other classic games have long been Nintendo's main draw.
The company also announced new entertainment features for the console. Called "Nintendo TVii," the service collects all the ways users have to watch movies, TV shows and sports. This includes pay-TV accounts along with services such as Hulu and Netflix. The GamePad works as a fancy remote controller and will let viewers browse shows they can watch.
TVii "brings all of your services to one place," said Reggie Fils-Aime, president and chief operating officer of Nintendo of America.
So if you like the TV show Modern Family, for example, it will pull in the show's episodes from every available source.
The service also captures scenes from live TV and displays them on the controller. Viewers can then comment on the scenes and share that on Twitter or Facebook if they want. With this feature, Nintendo is playing into what many people already do while they watch TV — comment and share things with friends using a second screen such as a smartphone.
TVii will be available Nov. 18 as well, at no extra cost.
Among the games available on the Wii U will be Activision Blizzard Inc.'s Call of Duty Black Ops II. The Call of Duty games have been holiday bestsellers for the past several years.
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Working Papers
State Rights over Water and Agricultural Productivity: Evidence from the Krishna Basin [Full Text] (Revise and Resubmit, Economic Development and Cultural Change)
The Impact of Temporary Work Guarantee Programs on Children's Education: Evidence from the Mahatma Gandhi National Rural Employment Guarantee Act from India (with Abhilasha Singh) [Full Text] (Under Review)
Women's Reservation and India's National Rural Employment Guarantee Scheme (with Nayana Bose) [Full Text]
This paper examines the impact of political reservations for women on a large public works program in India. Since 1993, one third of the Panchayats in India have been randomly restricted to fielding only woman candidates. We use detailed information on employment and public works expenditure at the Panchayat level under the Indian National Rural Employment Guarantee Act (NREGA) from 2010 to 2013 for Uttar Pradesh and combine this with information on local level electoral information. Exploiting the randomized assignment of female candidate reservations, we find that demand for work and women's labor force participation significantly increase in Panchayats with women leaders. However, we find no significant effects on the type of work that is undertaken in these areas. Thus, although we find some evidence of a role-model effect, we find no evidence of better public works distribution under female leaders.
Women's Inheritance Rights, Household Allocation and Gender Bias(with Nayana Bose)
This paper examines the effects of empowering women with increased rights to property on human capital accumulation and intra-household allocation towards girls. The Hindu Succession (Amendment) Act of 2005 extended ancestral property rights to unmarried daughters, however, five southern states in India had already passed the same amendment by 1994. Employing a difference-in-difference strategy, we find that the policy significantly increased women's education, on average, by 0.72 years of schooling. The effect, however, is concentrated among the younger cohorts rather than the older cohorts. We further find that daughters of mothers who were less than 10 years of age at the time of the reform, significantly gain 0.44 years of education. Examining various consumption categories, we find no significant effect on household expenditure patterns as a result of the reforms.
Works in Progress
Impact of NREGA on agriculture and farmer suicide
Improving access to water through water allocation and NREGA works
Permanent Working Paper


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Supplying Mayfair its pizza fix since 1957, Delfino still heaves with casual diners who squeeze into velvet banquettes to demolish crisp, wood-fired crusts & generous toppings. From 22
varieties, it's easy to pick a favourite (margherita, American hot, fiorentina, quattro formaggi, they're all here), although there are also a few more creative efforts such as prati e monti (a
two-in-one combo involving goats' cheese calzone & a conventional spinach & olive riff). But any similarity to popular chains ends there – staff are engaging & know the regulars, the
interior is a wacky mix of red, yellow & turquoise, & the menu is bolstered by an innovative spread of pastas & grills including succulent lamb cutlets on pearl barley risotto.
Proceedings can be rowdy, no doubt helped along by the eminently affordable wine list.
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34 year old man | Coppell, TX, USA | Seeking women 19-43 within 20 miles
My name is Justin, I am a honest gentlemen...
My name is Justin, I am a honest gentlemen looking for a older or younger woman that likes to go out often have fun seeing movies, concerts, going to the lake, etc. I like to spend a lot of my time with other people doing new things, seeing new places or just going out to eat. I love all types of music but there's just one I cant be without.(guess). I enjoy spending my time away from my home trying new things. But I'm never against crashing for a movie night and more. Though I am sort of TV addict, but not as much as book. When talking online and can be a little shy. But when meeting new people, but I warm up fast once I see you face to face. People would say I'm the guy that makes the whole room laugh alot and that I'm very self-confident. If this sounds like someone you'd like to talk send me a message!
Book club , Coffee and conversation , Business networking , Cooking , Dining out , Fishing/Hunting , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing cards , Playing sports , Political interests , Religion/Spiritual , Shopping/Antiques , Travel/Sightseeing , Video games , Volunteering , Watching sports , Wine tasting
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I don't believe in astrology
I have Dogs
I own a Papillon puppy (the breed is also known as "Butterfly dog") who is very fun to play with and licks everything in site.
North Lake College, Irving, TX
I like riding my bike, reading, going out doing almost anything away from home,spending time with others doing whatever?
movies, going out to dinner, museums. I'm usually up for just about anything.
Decision Points, Nowhere To Hide
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|$50,001 to $75,000
|No preference
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|Have kids:
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|White / Caucasian
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|Chinese, English, Japanese
|Some college
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I'm currently working on a degree in business.


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Dunlop Pedals
Dunlop Band of Gypsys FFM6 Fuzz Face MiniThis limited edition mini box doesn't house a typical FF-style circuit; there are far more components. A Fuzz Face, it ain't. What it is, is a pitch-perfect recreation of Jimi's Octavio without the upper octave. It's a biting, creamy fuzz that sounds perfectly and sublimely un... read more$119.99
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'Prince Avalanche' Director David Gordon Green, Emile Hirsch Go Into the Woods (Video)
The director and actor talk to THR about shooting the film in just 16 days in Texas.
David Gordon Green makes a significant departure from his recent string of studio comedies with his latest film, Prince Avalanche.
Starring Paul Rudd and Emile Hirsch, the film follows two road workers who spend the summer in Texas repaving roads after a devastating forest fire.
Green, whose past films include The Sitter, Your Highness and Pineapple Express, says that he went from conceiving the idea for Prince Avalanche to soundmixing the final product in five months.
"In most of my projects, I haven't finished the first draft of the script in that amount of time," says Green, whose diverse career also includes helming George Washington and All the Real Girls.
The project was shot in just 16 days in Texas, without the media knowing the production was going on.
"When you're making a movie about two dudes walking around in the woods, you don't need that burden. And so I thought it would be a good idea to keep this production on the down low," he says.
VIDEO: 'Prince Avalanche' Trailer: Paul Rudd, Emile Hirsch Get Testy in the Texas Heat
Hirsch, who plays Rudd's character's brother-in-law who would rather be partying in nightclubs than working the road, says the fast-paced shooting schedule was an advantage.
"Sometimes actors will have too much time to over-think something to the point where it just becomes counterproductive to them," he tells THR, adding that he and Rudd had to completely follow their instincts on the film.
Hirsch and Green say that Rudd, known primarily for his comedy work in films like This Is 40 and Our Idiot Brother, has a more serious side to him, which may surprise some people.
"I think the thing that would probably be most surprising about Paul is if people know what an edgy badass Paul kind of is," says Hirsch. "Paul can be really funny and sweet. But he's also, when he wants to be, a really serious, intense dude."
Adds Green: "He's quite handy. He can fix your car, and build you a house too. Emile can't, but Emile is a better dancer."
Prince Avalanche opens in theaters on Aug. 9 via Magnolia Pictures.
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Moran will deliver the keynote address and receive an honorary doctor of commercial science degree at the ceremony on Saturday, May 18, 2013, at 3:00 p.m. on the south campus.
You are here
Newsroom: News
Economics Professor Scott Sumner is highlighted for his participation on the "market monetarism" panel held at the American Enterprise Institute.
The Bloomberg Businessweek rankings for the top business schools in the country were recently announced with Bentley moving into the 20th spot.
In the 2013 "Best Undergraduate Business Schools" rankings by Bloomberg BusinessWeek, Bentley University ranks at #20 overall.
Economics Professor Scott Sumner offers insight on the Fed keeping interest rates low
The Jacobs Brothers will deliver the commencement address to approximately 1,000 Bentley University undergraduate students on Saturday, May 18, 2013 at 10:00 a.m. on the south campus of Bentley University, with an expected 7,000 in attendance.
The Bentley University Graduate School of Business is ranked among the top 100 graduate business schools in the country and one of the top five in New England in the recently released U.S. News & World Report rankings of America's Best Graduate Business Schools 2014.
Taking social responsibility lessons beyond the classroom, Bentley announces the first recipients of the Gerald R. Ferrera Service Fellowships for summer 2013 non-profit internships: sophomore Patricia Guiao, and junior Hanna Wolsfelt.
Bentley University is giving two high school students the chance to play in the big leagues and learn about the business aspects of professional sports through internships with the Boston Red Sox and Yankees.com.
A new look and campaign for a business university. Learn more.


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Westbury High School celebrates homecoming
Westbury high school celebrated homecoming with several events on Oct. 26.
H.S. homecomings
2014 H.S. proms
LI historic sites
Town officials
Festivals & Fairs
West Babylon HS homecoming Elwood HS homecoming Deer Park High School homecoming Valley Stream Central homecoming photos Miller Place HS homecoming Farmingdale HS homecoming High school homecomings on LI Mr. and Miss West Islip competition The evolution of LI cheerleaders North Shore HS homecoming Meet LI's homecoming kings and queens from Nassau Meet LI's homecoming kings and queens from Suffolk