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Are you Kristin Bergethon?Claim your profile
Publications (12)112.22 Total impact
- SourceAvailable from: Scott L Pomeroy[Show abstract] [Hide abstract]
ABSTRACT: WTX is a tumor suppressor gene expressed during embryonic development and inactivated in 20-30% of cases of Wilms tumor, the most common pediatric kidney cancer. WTX has been implicated in several cellular processes including Wnt signaling, WT1 transcription, NRF2 degradation, and p53 function. Given that WTX is widely expressed during embryonic development and has been recently shown to regulate mesenchymal precursor cells in several organs, we tested for the potential involvement of WTX in a panel of pediatric tumors and adult sarcomas. A total of 353 tumors were screened for WTX deletions by fluorescence in situ hybridization (FISH). Discrete somatic WTX deletions were identified in two cases, one hepatoblastoma and one embryonal rhabdomyosarcoma, and confirmed by array comparative genomic hybridization. Direct sequencing of the full WTX open reading frame in 24 hepatoblastomas and 21 embryonal rhabdomyosarcomas did not identify additional mutations in these tumor types. The presence of WTX mRNA was confirmed in hepatoblastomas and embryonal rhabdomyosarcomas without WTX deletions by RNA-in situ hybridization. Notably, tumors with evidence of WTX inactivation, Wilms tumor, hepatoblastoma and rhabdomyosarcoma, are primitive tumors that resemble undifferentiated precursor cells and are linked to overgrowth syndromes. These results indicate that WTX inactivation occurs in a wider variety of tumor types than previously appreciated and point to shared pathogenic mechanisms between a subset of pediatric malignancies. © 2013 Wiley Periodicals, Inc.Genes Chromosomes and Cancer 01/2014; 53(1):67-77. DOI:10.1002/gcc.22118 · 3.84 Impact Factor
Article: Detection of Novel Actionable Genetic Changes in Salivary Duct Carcinoma Helps Direct Patient Treatment.[Show abstract] [Hide abstract]
ABSTRACT: PURPOSE: Salivary duct carcinomas (SDC) are a rare and aggressive subtype of salivary gland cancers for which cytotoxic chemotherapy has limited efficacy. We investigated whether genotyping analysis could detect novel tumor-specific mutations that would help direct SDC patient treatment using targeted agents. EXPERIMENTAL DESIGN: We genotyped twenty-seven SDC archival specimens from patients followed at Massachusetts General Hospital and Massachusetts Eye and Ear Infirmary between 2000 and 2011. These included the tumors of 8 patients who were tested prospectively. Targeted mutational analysis of 13 clinically-relevant cancer genes was performed using SNaPshot multiplexed genotyping. FISH was performed to detect HER2 gene amplification. Patient medical records and tumor histopathological features were retrospectively reviewed. RESULTS: Mutually exclusive genetic aberrations were detected in 15 of 27 (56%) tumors, including 2 (7%) mutations in BRAF, 5 (19%) mutations in PIK3CA, and 8 (30%) cases of HER2 gene amplification. To our knowledge, this is the first time that BRAF and PIK3CA mutations have been reported in this tumor type. Prospective clinical testing of 8 SDC patients identified actionable genetic alterations in 6 tumors and influenced therapeutic decisions for all 6 patients. CONCLUSIONS: SNaPshot molecular profiling identified novel genetic changes in SDCs, expanded the therapeutic options for patients with this rare tumor, and is changing SDC management at our institution. These findings highlight the importance of using broad based genetic profiling to expedite the identification of effective targeted therapies for patients with rare malignancies.Clinical Cancer Research 11/2012; DOI:10.1158/1078-0432.CCR-12-1842 · 8.19 Impact Factor
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ABSTRACT: Chromosomal rearrangements leading to constitutive activation of anaplastic lymphoma receptor tyrosine kinase (ALK) define a category of lung adenocarcinomas that may be amenable to targeted therapy with the ALK inhibitor crizotinib. Defining distinctive features of ALK-rearranged (ALK+) lung adenocarcinomas may help identify cases that merit molecular testing. However, data describing the morphologic features of ALK+ lung adenocarcinomas are conflicting and are primarily based on analysis of resected primary lung tumors. It is unclear whether the findings from prior studies are applicable to metastatic lung tumors or to small biopsy/cytology specimens. To address these issues, we examined resection, excision, small biopsy, and cytology cell block specimens from 104 ALK+ and 215 ALK- lung adenocarcinomas from primary and metastatic sites. All cases were evaluated for ALK rearrangements by fluorescence in situ hybridization. The predominant histologic subtypes and distinctive cytomorphologic features were assessed in each case. Primary ALK+ lung adenocarcinomas showed a significant association with solid, micropapillary, and papillary-predominant histologic patterns and tumor cells with a signet ring or hepatoid cytomorphology. Among metastatic lung tumors and small biopsy/cytology specimens, the only distinguishing morphologic feature of ALK+ tumors was the presence of signet ring cells. Based on these results, we developed a morphology-based scoring system for predicting ALK rearrangements in lung adenocarcinomas. The scoring system predicted ALK rearrangements in a new cohort of 78 lung adenocarcinomas (29 ALK+ and 49 ALK-) with a sensitivity of 88% and a specificity of 45%. In conclusion, ALK+ lung adenocarcinomas have distinctive morphologic features, with signet ring cells showing a significant association with ALK rearrangements irrespective of tumor site (primary vs metastatic) or specimen type. However, morphologic screening alone will not detect a minority of ALK+ lung adenocarcinomas, and the routine use of ancillary studies may be warranted to identify all patients who may benefit from crizotinib treatment.Modern Pathology advance online publication, 29 June 2012; doi:10.1038/modpathol.2012.109.Modern Pathology 06/2012; 25(11). DOI:10.1038/modpathol.2012.109 · 6.36 Impact Factor
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ABSTRACT: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor, often metastatic at presentation, for which current chemotherapeutic regimens are largely ineffective. As its pathogenesis is still unknown, we hypothesized that deregulation of signaling pathways commonly activated in cancer may contribute to MCC tumorigenesis and may provide insights into targeted therapy approaches for this malignancy. We retrospectively profiled 60 primary MCC samples using a SNaPshot-based tumor genotyping assay to screen for common mutations in 13 cancer genes. We identified mutations in 9 (15%) MCC primary tumors, including mutations in TP53 (3 of 60) and activating mutations in the PIK3CA gene (6 of 60). Sanger sequencing of the primary MCC tumors detected one additional PIK3CA mutation (R19K) that had not been previously described in cancer. Merkel cell polyoma virus (MCPyV) was detected in 38 (66%) MCC cases and patients with MCPyV-positive cancers showed a trend toward better survival. With one exception, the presence of MCPyV and activating mutations in PIK3CA appeared mutually exclusive. We observed that signaling through the PI3K/pAKT pathway was active in one MCPyV-positive and in all MCPyV-negative MCC cell lines, as evidenced by AKT phosphorylation. Importantly, the presence of a PIK3CA-activating mutation was associated with sensitivity to treatment with ZST474, a specific phosphoinositide 3-kinase (PI3K) inhibitor, and to NVP-BEZ235, a dual PI3K/mTOR inhibitor, targeted agents under active clinical development. PI3K pathway activation may drive tumorigenesis in a subset of MCC and screening these tumors for PIK3CA mutations could help identify patients who may respond to treatment with PI3K pathway inhibitors.Clinical Cancer Research 03/2012; 18(5):1227-36. DOI:10.1158/1078-0432.CCR-11-2308 · 8.19 Impact Factor
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ABSTRACT: Chromosomal rearrangements involving the ROS1 receptor tyrosine kinase gene have recently been described in a subset of non-small-cell lung cancers (NSCLCs). Because little is known about these tumors, we examined the clinical characteristics and treatment outcomes of patients with NSCLC with ROS1 rearrangement. Using a ROS1 fluorescent in situ hybridization (FISH) assay, we screened 1,073 patients with NSCLC and correlated ROS1 rearrangement status with clinical characteristics, overall survival, and when available, ALK rearrangement status. In vitro studies assessed the responsiveness of cells with ROS1 rearrangement to the tyrosine kinase inhibitor crizotinib. The clinical response of one patient with ROS1-rearranged NSCLC to crizotinib was investigated as part of an expanded phase I cohort. Of 1,073 tumors screened, 18 (1.7%) were ROS1 rearranged by FISH, and 31 (2.9%) were ALK rearranged. Compared with the ROS1-negative group, patients with ROS1 rearrangements were significantly younger and more likely to be never-smokers (each P < .001). All of the ROS1-positive tumors were adenocarcinomas, with a tendency toward higher grade. ROS1-positive and -negative groups showed no difference in overall survival. The HCC78 ROS1-rearranged NSCLC cell line and 293 cells transfected with CD74-ROS1 showed evidence of sensitivity to crizotinib. The patient treated with crizotinib showed tumor shrinkage, with a near complete response. ROS1 rearrangement defines a molecular subset of NSCLC with distinct clinical characteristics that are similar to those observed in patients with ALK-rearranged NSCLC. Crizotinib shows in vitro activity and early evidence of clinical activity in ROS1-rearranged NSCLC.Journal of Clinical Oncology 01/2012; 30(8):863-70. DOI:10.1200/JCO.2011.35.6345 · 17.88 Impact Factor
Article: MET Amplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib[Show abstract] [Hide abstract]
ABSTRACT: Amplification of the MET proto-oncogene in gastroesophageal cancer (GEC) may constitute a molecular marker for targeted therapy. We examined a GEC cohort with follow-up and reported the clinical response of four additional patients with MET-amplified tumors to the small molecule inhibitor crizotinib as part of an expanded phase I cohort study. From 2007 to 2009, patients with GEC were genetically screened as a consecutive series of 489 tumors (stages 0, I, and II, 39%; III, 25%; IV, 36%; n = 222 esophageal, including n = 21 squamous carcinomas). MET, EGFR, and HER2 amplification status was assessed by using fluorescence in situ hybridization. Ten (2%) of 489 patients screened harbored MET amplification; 23 (4.7%) harbored EGFR amplification; 45 (8.9%) harbored HER2 amplification; and 411 (84%) were wild type for all three genes (ie, negative). MET-amplified tumors were typically high-grade adenocarcinomas that presented at advanced stages (5%; n = 4 of 80). EGFR-amplified tumors showed the highest fraction of squamous cell carcinoma (17%; n = 4 of 23). HER2, MET, and EGFR amplification were, with one exception (MET and EGFR positive), mutually exclusive events. Survival analysis in patients with stages III and IV disease showed substantially shorter median survival in MET/EGFR-amplified groups, with a rank order for all groups by median survival (from most to least aggressive): MET (7.1 months; P < .001) less than EGFR (11.2 months; P = .16) less than HER2 (16.9 months; P = .89) when compared with the negative group (16.2 months). Two of four patients with MET-amplified tumors treated with crizotinib experienced tumor shrinkage (-30% and -16%) and experienced progression after 3.7 and 3.5 months. MET amplification defines a small and aggressive subset of GEC with indications of transient sensitivity to the targeted MET inhibitor crizotinib (PF-02341066).Journal of Clinical Oncology 12/2011; 29(36):4803-10. DOI:10.1200/JCO.2011.35.4928 · 17.88 Impact Factor
Article: The dichotomy in carcinogenesis of the distal esophagus and esophagogastric junction: intestinal-type vs cardiac-type mucosa-associated adenocarcinoma[Show abstract] [Hide abstract]
ABSTRACT: Adenocarcinoma of the distal esophagus and esophagogastric junction continues to rise in incidence. An intestinal metaplasia (Barrett esophagus)-dysplasia-carcinoma sequence induced by gastroesophageal reflux disease is well established. However, a significant number of adenocarcinomas in the vicinity of the esophagogastric junction are seen in the background of gastric/cardiac-type mucosa without intestinal metaplasia. Thus, the aim of this study was to investigate the role of Barrett esophagus (intestinal-type mucosa) in the classification and prognosis of tumors of the distal esophagus and esophagogastric junction. Clinicopathological and molecular characteristics were examined in 157 consecutively resected adenocarcinomas of the distal esophagus and esophagogastric junction and were compared between tumors arising in association with intestinal-type and cardiac-type mucosa. Intestinal-type mucosa-associated adenocarcinomas were more likely to be associated with younger age (P=0.0057), reflux symptoms (P<0.0001), proximal location (P=0.0009), lower T stage (P<0.0001), fewer nodal metastases (P=0.0001), absence of lymphatic (P<0.0001), venous (P=0.0060) or perineural (P<0.0001) invasion. Histologically, intestinal-type mucosa-associated tumors were more likely to be low-grade glandular tumors (P=0.0095) of intestinal or mixed immunophenotype (P=0.015) and express nuclear β-catenin (P=0.0080), whereas tumors arising in a background of cardiac-type mucosa were more frequently associated with EGFR amplification (P=0.0051). Five-year overall survival rate was significantly higher in patients with intestinal-type mucosa-associated tumors (28 vs 9%, P=0.0015), although no survival benefit was seen after adjusting for potential confounders. Our findings support the theory that multiple distinct pathways of tumorigenesis exist in the vicinity of the esophagogastric junction, including one in which tumors arise from dysplastic intestinal metaplasia (intestinal pathway), and one potentially involving dysplasia of the cardiac-type mucosa (non-intestinal pathway). Additional studies are warranted to further clarify their pathogenesis and the molecular mechanisms involved.Modern Pathology 05/2011; 24(9):1177-90. DOI:10.1038/modpathol.2011.77 · 6.36 Impact Factor
Article: Activity of Crizotinib (PF02341066), a Dual Mesenchymal-Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) Inhibitor, in a Non-small Cell Lung Cancer Patient with De Novo MET Amplification[Show abstract] [Hide abstract]
ABSTRACT: Crizotinib is a dual MET and ALK inhibitor. Currently, clinical development of crizotinib is focused primarily on ALK rearranged non-small cell lung cancer (NSCLC). Here we report an NSCLC patient with de novo MET amplification but no ALK rearrangement who achieved a rapid and durable response to crizotinib indicating is also a bona fide MET inhibitor.Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 05/2011; 6(5):942-6. DOI:10.1097/JTO.0b013e31821528d3 · 5.80 Impact Factor
- Cancer Research 04/2011; 71(8 Supplement):2210-2210. DOI:10.1158/1538-7445.AM2011-2210 · 9.28 Impact Factor
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ABSTRACT: Metastasizing adnexal carcinomas are rare; thus, currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional therapeutic approaches. We performed immunohistochemistry (epidermal growth factor receptor (EGFR), HER2, and CD117), EGFR and ERBB2 fluorescence in situ hybridization (FISH), and multiplexed SNaPshot® genotyping (testing for recurrent mutations in 15 cancer genes including BRAF, EGFR, KRAS, PIK3CA, and TP53) on primary tumors and corresponding metastases of 14 metastasizing adnexal carcinomas (three apocrine, six eccrine, two hidradenocarcinomas, two porocarcinomas, and one aggressive digital papillary adenocarcinoma). Metastasis to regional lymph node was most common, followed by skin and then lungs. Follow-up was available in 12 patients (5 months to 8 years) with 1 died of widespread metastases. Although EGFR overexpression was a prevalent feature in this cohort, seen in 7/11 (64%) primary tumors and 10/14 (71%) metastases; FISH for EGFR gene amplification was negative in 9 tested primary tumors and 12 metastases. FISH of the one primary tumor and three metastases with 2+ HER2 overexpression revealed a low level of ERBB2 gene amplification in one apocrine carcinoma and corresponding metastasis. CD117 expression was seen only in rare cases. PIK3CA (2/12, 17%) and TP53 (3/12, 25%) mutations were detected in two (one hidradenocarcinoma, one porocarcinoma) and three (one eccrine, one hidradenocarcinoma, and one aggressive digital papillary adenocarcinoma) cases, respectively. The role of EGFR inhibitor therapy in metastasizing adnexal carcinomas with protein overexpression remains unclear. Targeted therapy including PI3K pathway inhibitors might be a potential treatment for rare cases of adnexal carcinomas with metastases.Modern Pathology 03/2011; 24(7):974-82. DOI:10.1038/modpathol.2011.48 · 6.36 Impact Factor
Article: Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors[Show abstract] [Hide abstract]
ABSTRACT: Lung cancers harboring mutations in the epidermal growth factor receptor (EGFR) respond to EGFR tyrosine kinase inhibitors, but drug resistance invariably emerges. To elucidate mechanisms of acquired drug resistance, we performed systematic genetic and histological analyses of tumor biopsies from 37 patients with drug-resistant non-small cell lung cancers (NSCLCs) carrying EGFR mutations. All drug-resistant tumors retained their original activating EGFR mutations, and some acquired known mechanisms of resistance including the EGFR T790M mutation or MET gene amplification. Some resistant cancers showed unexpected genetic changes including EGFR amplification and mutations in the PIK3CA gene, whereas others underwent a pronounced epithelial-to-mesenchymal transition. Surprisingly, five resistant tumors (14%) transformed from NSCLC into small cell lung cancer (SCLC) and were sensitive to standard SCLC treatments. In three patients, serial biopsies revealed that genetic mechanisms of resistance were lost in the absence of the continued selective pressure of EGFR inhibitor treatment, and such cancers were sensitive to a second round of treatment with EGFR inhibitors. Collectively, these results deepen our understanding of resistance to EGFR inhibitors and underscore the importance of repeatedly assessing cancers throughout the course of the disease.Science translational medicine 03/2011; 3(75):75ra26. DOI:10.1126/scitranslmed.3002003 · 14.41 Impact Factor
Article: BRAF Gene Amplification Can Promote Acquired Resistance to MEK Inhibitors in Cancer Cells Harboring the BRAF V600E Mutation[Show abstract] [Hide abstract]
ABSTRACT: Oncogenic BRAF mutations are found in several tumor types, including melanomas and colorectal cancers. Tumors with BRAF mutations have increased mitogen-activated protein kinase pathway activity and heightened sensitivity to BRAF and MEK (mitogen-activated or extracellular signal-regulated protein kinase kinase) inhibitors. To identify potential mechanisms of acquired drug resistance, we generated clones resistant to the allosteric MEK inhibitor AZD6244 from two BRAF V600E mutant colorectal cancer cell lines that are highly sensitive to MEK or BRAF inhibition. These AZD6244-resistant (AR) clones, which exhibited cross-resistance to BRAF inhibitors, acquired resistance through amplification of the BRAF gene. A small percentage of treatment-naïve parental cells showed preexisting BRAF amplification. We observed similar amplification in a subset of cells in a BRAF-mutant colorectal cancer. In cell lines, BRAF amplification increased the abundance of phosphorylated MEK and impaired the ability of AZD6244 to inhibit ERK (extracellular signal-regulated kinase) phosphorylation. The ability of AZD6244 to inhibit ERK phosphorylation in AR cells was restored by treatment with a BRAF inhibitor at low concentrations that reduced the abundance of phosphorylated MEK to amounts observed in parental cells. Combined MEK and BRAF inhibition fully overcame resistance to MEK or BRAF inhibitors alone and was also more effective in parental cells compared to treatment with either inhibitor alone. These findings implicate BRAF amplification as a mechanism of resistance to both MEK and BRAF inhibitors and suggest combined MEK and BRAF inhibition as a clinical strategy to overcome, or possibly prevent, this mechanism of resistance.Science Signaling 11/2010; 3(149):ra84. DOI:10.1126/scisignal.2001148 · 7.65 Impact Factor
Top Journals
Massachusetts General Hospital
Boston, Massachusetts, United States
- Department of Pathology
Harvard UniversityCambridge, Massachusetts, United States


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Newspaper's Litmus Test: How local newspaper sites should be looking at their online ventures in a different light: "A litmus test is how your company views all those thousands of unique visitors who read the newspaper's content online for free. If the opinion is that they should either subscribe to the paper or pay an access fee, you work for a newspaper company. If the opinion is that the Internet presents a new business model that deserves time and resources, you work for a media company."
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NOLA Music Festival 2015 Party Packages
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Jazz Brunch
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New Orleans, LA
Join us for one of New Orleans most popular Jazz Brunches, featuring the Some Like It Hot! traditional jazz band.
Join millions of people on Eventbrite.


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Kenosha, WI
Comment, Like, Favorite
Expert Printing and Assembly
Shipping Within 2 - 3 Business Days
Millions of Satisfied Customers
Cranberry Colored Lily
Kay Novy
Photograph - Photography
A beautiful cranberrry red colored lily.
Daylily is the common name for plants of the genus Hemerocallis. Daylily cultivar flowers are highly diverse in colour and form, as a result of hybridization efforts of gardening enthusiasts and professional horticulturalists.
Most kinds of daylilies occur as clumps, each of which has leaves, a crown, flowers, and roots. The long, linear lanceolate leaves are grouped into opposite fans with arching leaves. The crown is the small white portion between the leaves and the roots. Along the scape of some kinds of daylilies, small leafy "proliferations" form at nodes or in bracts. A proliferation forms roots when planted and is often an exact clone of its parent plant. Many kinds of daylilies have thickened roots in which they store food and water.
A normal, single daylily flower has three petals and three sepals, collectively called tepals, each with a midrib in either the same or a contrasting color. The centermost part of the flower, called the throat, usually is of a different color than the more distal areas of the tepals. Each flower usually has six stamens, each with a two-lobed anther. After successful pollination, a flower forms a capsule (often erroneously called a pod).
July 3rd, 2013
Viewed 678 Times - Last Visitor from Pittsburgh, PA on 06/28/2015 at 9:10 AM
Sales Sheet
More from Kay Novy
Riverview, FL - United States
Beautiful picture with nice composition. It looks like the light is shinning through the flower.
Thank you, Norman.
Quincy, IL - United States
Gorgeous lily! I was excited to see this because I have some too.. and haven't seen others! LFTweeted
Thank you, Pamela (Luther Fine Art).
Quincy, IL - United States
Gorgeous lily! I was excited to see this because I have some too.. and haven't seen others! LFTweeted
Allentown, PA - United States
Kay, Congrats on your Featured Image in WFS ! Nice work with this Image with Beautiful color flower. V
Thanks so much, Jeannie.
Northridge, CA - United States
This is so gorgeous. l,f,t,
Thank you, Bedros. Appreciated!
Chandler, AZ - United States
Very pretty, Kay! v
Thank you, Marilyn.
Fort Worth, TX - United States
lovely! v254
Thank you, Joan.
Wayne, NJ - United States
Great light and detail Kay, liked.
Thank you, Lloyd.
Winnipeg, MB - Canada
Beautiful image. f/v
Thank you, Teresa.
Jacksonville, fl - United States
Beautiful capture..great title..v
Thanks so very much, Sherry.
Barcelona, Ba - Spain
Nice work!
Thank you, Victoria.
Daytona Beach, FL - United States
Beautiful Image!
Thank you, Will.
Mililani, HI - United States
Beautiful colors! v
Thank you, Julie.
Mount Airy, MD - United States
Neat color-scape, Kay. Well done. - Mike (V)
Thank you, Mike.
Longview, TX - United States
Very pretty and nice composition! V
Thank you, Amanda.
Sykesville, MD - United States
Gorgeous! L.
Thank you, Patti.
Dearborn, MI - United States
Beautiful work. V
Thank you, John.
New Bedford, MA - United States
Great artwork! v
Thank you, Andrea.
Nalcrest, FL - United States
Outstanding work!
Thank you, Zulfiya.
Boynton Beach, FL - United States
Stunning! fave!
Thank you, Judy.
Yangon, Ya - Myanmar
Great work! v
Thank you, David.
Cambridge, ON - Canada
Magnificent! Happy New Year! L/F
Thanks Hanne.
Deerfield Beach, FL - United States
Thank you, Janis.
Singapore, SG - Singapore
Love the cranberry red of this lovely flower! f/v
Thank you, Belinda.
Copiague, NY - United States
Very Nice:o)
Thank you, Melanie.
M�lheim An Der Ruhr - Germany
Beautifully done. v
Thank you, Britta.
Rehoboth, MA - United States
Beautifully captured
Thanks so much, Joan.
Moscow, Mo - Russian Federation
Watched, wowed, loved, voted, faved! :-)
Thank you, Alexander. Appreciated!
Dixfield, ME - United States
Lovely capture Kay/V
Bend, OR - United States
Thanks Leah.
Cresskill, NJ - United States
Very pretty!
Bremen - Germany
Georgeous work V
Crisfield, MD - United States
A real beauty, Kay! L/f
Caledon, ON - Canada
Superb image. v/f
Silver Spring, MD - United States
Whoa - this popped right out at me. Awesome composition! Great angle. Love the dark red with yellow. Flower colors are quite vivid!! Wonderful wonderful wonderful!!! L.
Surrey, BC - Canada
Gorgeous, Kay!!
Farmington, NM - United States
Casa Grande, AZ - United States
Beautiful Cranberry Color...v
Cockeysville, MD - United States
Very nice and delicate!
Cedar Rapids, IA - United States
Lovely lily photo! L!
Summerville, SC - United States
Your work is being promoted by our group Beauty Captured!
Denton, TX - United States
So beautiful Kay and love the color of the lily. F/Like Ruth
Thank you so very much, Ruth.
Holden, MA - United States
Love that cranberry with the yellow! Fav/Like
Thank you, Luke.
SJ, NL - Canada
Such beautiful image! Love the strong color and the amazing details! V
New York, NY - United States
Beautiful color and details! V
Thank you, James.
Asheville, NC - United States
Beautiful work! v
Thanks Carol.
San Diego, CA - United States
Nice color and values in this one
Thank You!
Philadelphia, PA - United States
beautiful, voted
Thanks Bener.
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Beverly Hills, CA (United States)
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All quotes tagged Discipline
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"Discipline is doing what you are supposed to do in the best possible manner at the time you are supposed to do it"
"To enjoy the good health, to bring the truth happiness, to care of his own family, to bring the peace to all. Firstly, one must discipline and control his own mind. if he can do so, the enlightenment, wisdom and virtue will go to him naturally."
"Sometimes it seems that the easy way is the best path to follow, but don't be fooled by short-term gains."
"Don't confuse 'spending money' with developing discipline, working tirelessly, and fixing problems with your sales skills."
"I really appreciate her focus and discipline, ... This industry is very powerful and overwhelming and intimidating. She knows it and has created her own culture within it. And that integrity. She's got it."


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Original recipe yields 8 servings
Amount per serving ({{servings}} total)
Based on a 2,000 calorie diet
Ready In
one of my favorite salads to serve with chicken and rice! I soften the raisins, by placing in a microwave-safe bowl with about a tablespoon of water, and microwave about 30 seconds. Then I dra...
I use a food processor to grate the carrots which makes this recipe all that much easier. This will become a staple at our house. Thanks!
Yummy! I was looking for a recipe similar to what my grandma used to make and this was very close. I think I might add a bit of orange juice or orange concentrate next time. It really doesn't...


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Saturday, October 6, 2012 - Memory of this is indistinct; Just recall it being somewhat disjointed and a bit too woody as though the all the fruit and nuance was hidden by the oak.
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2 officers injured breaking up Okla. bar fight
One of the officers required surgery after dislocating his shoulder and fracturing his ankle
The Norman Transcript
NORMAN, Okla. — A Norman police officer injured breaking up a bar fight this past week underwent surgery Tuesday morning, police said.
MPO Matt Woodard, a K-9 officer, and Officer Tara Taylor responded to a disturbance May 8 in the bar at Sooner Legends, 1200 24th Ave. SW.
Police spokesman Capt. Tom Easley said when the officers arrived, they encountered two men in a fight. When the officers approached, one of the subjects charged the officers, Easley said.
"MPO Woodard attempted to take the subject into custody and in the process, the suspect, Woodard, and Taylor fell to the floor," Easley said. "Woodard injured his left shoulder and left ankle. Taylor injured her right knee."
Woodard was taken to Norman Regional Hospital and treated for a dislocated shoulder and fractured left ankle. Taylor was diagnosed with a knee contusion and released.
Chadric Lynn West, 39, was charged in Cleveland County District Court on May 8 with resisting arrest, public drunk or intoxication and disturbing the peace.
Joshua D. West, 34, was arrested on complaints of public drunk and on an Oklahoma County arrest warrant. Joshua West's charges are pending in municipal court.
Reprinted with permission from The Norman Transcript
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How cute is that? Freckles on the ass. I could smooch them!
She is the reason I join Met. The sucking thing was was when I joined they took her off the roster. So I emailed and ask for her back. Thank for putting this Angel back on. I enjoy all her sets. She my number 1 model.
A lovely brunette petite sexbomb. Rylsky has a way of bringing out something of the personality in his models, and Night positively sparkles with it.
Welcome Back!
So beautiful girl. Could be nice to another photogarpher pictures of her. I do not like Rylsky overexposed pictures and his love for Photoshop.
Super sexy neck
Night! Noc! Now! More please? She is by far the hottest, sexiest, cutest, loveliest, most gorgeous woman I have ever laid my eyes on! I am hooked! Did I say more, please? Even if she is fully clothed, I don't care! She is perfect! Yes! Yes! Yes! More Please?
GmanDan2013, you are absolutely right. Night A is indeed the most gorgeous model. She is a sex bomb.
what a mega-tiny dream of a body!!! I love you
Night is her totally beautiful self, and Rylsky has chosen the perfect background for her. I am very glad she has quit dyeing her hair and also has gone back to just trimming. She looks a lot better.
She is best beautiful with armpit hair... more of her please!
She's a great addition to the collection...but small request...open your lips more...and lets see u very wet baby...yummy!!!
Captivating eyes. Very sexy body. Petite at it's finest. A true favorite.
Night A. a true Beauty, Beautiful Eyes, Great lips, perfect Breasts, nice round ass, Great big Labia/Clit, perfect Body, Great shape, a natural.
Those eyes that body that cute bush wow!
More sets of model Night A on the Met Art Network:


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Art and Crafts
Thomas Kinkade Musical Santa and Mrs. Claus Figurine
Revolving Santa's Sleigh and Star Christmas Tree Topper
And to All A Good Night Christmas Sculpture
Holiday Splendor Nativity Music Box
Family Gathering Musical Motion Ornament
Silicone Dipped Pumpkin Bulb
Thomas Kinkade Traditional Musical Santa Doll
Illuminated Angel of Peace Figurine
Holiday Gathering Musical and Illuminated Wall Sculpture
Stained Glass Bunny Night Light
Santa Claus is Comin' to Town Train Car
Tweety and Sylvester Christmas Tree Animated Snow Globe
Kneeling Santa Waterglobe
Thomas Kinkade Jingle Bells Musical Snowglobe
Santa Night Light
Tabletop Illuminated Nativity Tree with Narration
Tabletop Christmas Tree With Singing Jingle Cats
House with Tree Snow Globe
Thomas Kinkade Home for the Holidays Crystal Snowglobe
Animated Crystal Holiday Music Box
I'll Be Home for Christmas Music Box with Moving Train
Frost the Snowman with Little Threadbears Musical Figurine
Victorian Christmas Village Snowglobe
Illuminated Musical Snowman Wreath


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Community Support Links
Patient & Visitor
Sibling Classes
Sibling Class
This class is a fun interactive way to help prepare children for the birht of a new baby. A craft activity, sibling video and tour of the OB area helps your child feel more involved for the upcoming arrival of a new baby. Parents are encouraged to attend with their child. Call 623-5200 to enroll your child. The fee is $10.


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Founders Steve Setton and Ralph Dweck have known each other since they were kids. It wasn't until 2013, when Dweck was working on his father's men's and women's jewelry line, that he teamed up with Setton (and his family's apparel group) to launch Mr. Swim. Meant to be a modern vintage brand, blending the elegance of the 50s with modern design, the brand creates all their prints in-house. Based in NYC, their first line launches this spring and is already gaining momentum amongst retailers, including yours truly.
Bold swimwear and precision-cut base layers by the California-based designer
Bold swimwear and innovatively cut base layers by the California-based designer.


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Partner and principal at Chermayeff & Geismar Inc. for 30
years and designer of some of the most memorable posters and
definitive corporate-identity programs of the latter part of the
20th century.
Steff Geissbuhler always knew he wanted to be a graphic designer
and says, "In Switzerland, you didn't have to explain to your
parents what that was." Graphic design was, and is, integral to
Swiss culture. Geissbuhler and his school friends would peel
posters from the walls and columns of the town where they lived, by
designers such as Herbert Leupin, Celestino Piatti and Armin
Hofmann. They would steam apart the pasted clumps of posters in the
bathtub and then hang them to dry. Design also ran in Geissbuhler's
family: His godfather was a lithographer, his mother painted
porcelain and made her own tapestries and his maternal grandfather
was an architect. And, as if his chosen profession needed any
further blessing, his local school, with all tuition paid, happened
to be the Basel School of Design.
At Basel, under the tutelage of Emil Ruder, Donald Brun and Armin
Hofmann, Geissbuhler developed a predilection for illustration, as
well as typography. His first job was at J.R. Geigy, the
pharmaceutical company famous for its design department that, at
the time, was run by Max Schmid. The illustrative translations that
Geissbuhler had been schooled in at Basel perfectly suited the
representation of medical conditions and anatomy for use in Geigy
packaging, exhibitions and promotional literature. "I'm an
illustrator at heart," says Geissbuhler. "If you look at any of my
logotypes, for Alvin Ailey or Crane or Time Warner, whether it's
people, birds, or eyes and ears, they are all illustrative."
When Ken Hiebert, one of Geissbuhler's Basel classmates, was
appointed chair of graphic design at Philadelphia College of Art
(now The University of the Arts), he asked Geissbuhler for help in
developing the program. "We introduced a completely new thing
there," recalls Geissbuhler, who served as chair of the department
from 1973 to 1975. Geissbuhler and Hiebert recruited colleagues
such as Inge Druckery, Keith Godard and Hans Alleman, and began to
move things away from a prevailing advertising bias. "We imported
the whole Swiss design philosophy, 'less is more,' and the
importance of typography, color and drawing." During the seven and
one-half years he taught at the school, Geissbuhler also maintained
a freelance business working for Murphy, Levy, Wurman, Architects
and Urban Planners, in Philadelphia, and for George Nelson, whose
primary client at the time was Barneys in New York City.
Wanting to return to full-time practice, Geissbuhler moved to New
York City and spent a year designing corporate-identity systems at
Anspach Grossman Portugal (AGP). "I had a beautiful office with a
big tree in it," Geissbuhler remembers. "And they offered me a
partnership." But every night, as he left the AGP offices, he would
look across the street and into the window of another design firm,
Chermayeff & Geismar. The fact that the lights were on, and
that Ivan Chermayeff and Tom Geismar were still working, was
intriguing to Geissbuhler. In 1975, he was invited to join the firm
as an associate, and two years later, he became a partner. "At
first, I was worried about how I would fit in with these two
designers who had been working together so long they were like a
married couple," he says. It soon became clear, however, that he
worked well in their midst. "Like Ivan, I was doing illustrative
work with painting and drawing and ripped paper collages. And, like
Tom, I also had a refined sense of typography and a feeling for the
abstraction of symbols." Just like the poster he designed for a
lecture, in which he used the "eff" of Chermayeff and the "Geis" of
Geismar from which to build his own name, Geissbuhler filled a gap
between the two partners.
During his 30 years as partner and principal of Chermayeff &
Geismar Inc., Geissbuhler designed a vast array of memorable and
imaginative posters, and some of the most defining
corporate-identity programs of the latter part of the 20th century.
Among the notable posters was the one in which a massive
silhouetted Godzilla and King Kong hold paws as they amble into the
sunset—a bittersweet signifier for peace between Japan and the
United States. His logotypes are familiar in households across the
United States and include the NBC peacock and the TimeWarner
conflation of an eye and ear, as well as enduring symbols for
National Public Radio, Telemundo, Union Pacific, Conrad Hotels,
CARE International, the U.S. Environmental Protection Agency, Voice
of America, Radio Free Europe and MercyCorps.
Geissbuhler is a frequent lecturer at conferences and schools and
has served on the faculty at The Cooper Union in New York City. A
former president of AIGA's New York chapter and a national board
member, he is perceived as a leader within the international design
community for his tenure as U.S. president and director of
education for the prestigious Alliance Graphique Internationale.
In 2005, Chermayeff & Geismar's founding partners split off to
form a small creative studio, and Geissbuhler, with long-time
partners Keith Helmetag, Emanuela Frigerio and Jonathan Alger, will
continue to carry the legacy of the firm into the future as C&G
Geissbuhler is an unabashed modernist. "I totally embrace the good
old Bauhaus rules of reduction and clarification," he says. At the
same time, he's still an illustrator and believes that "actual
symbols mean more today than abstractions. My NBC peacock still
works today because people relate to something they can understand
right away." Driven by a need to make things that are meaningful
and appropriate, Geissbuhler always strives to answer the question,
to resolve the problem at hand, rather than to use a job as an
opportunity for personal expression.
The distinguished AIGA Medal is awarded to individuals in recognition of their exceptional achievements in the field of design.
Section: Inspiration -
AIGA Medal, design educators, students
See how our chapters toasted AIGA's centennial in their own way.
Section: Events and Competitions -
Event, AIGA chapters
Each year we seem to hear about the issue of racism in sports brands—particularly with Native American mascots. Throughout history, these logos have evolved. But is this enough?
Section: Inspiration -
branding, graphic design, diversity
With digital technology so ingrained in our lives, what is the fate of the old faithful slide show? Twemlow projects the future of the design collections.
Section: Inspiration -
Voice, professional development
Hermann Zapf, the designer of fonts such as Palatino, Optima, Zapfino, Melior, Aldus, and the bizarre but much beloved Zapf Dingbats, has died at age 96.
Section: Inspiration -
In memoriam, typography
Christian Dior temporary store
Ancun Zou
2010 Studio On Fire Letterpress Calendar
Studio On Fire
Alec Dudson on the new issue of Intern magazine, which looks at education
Posted by Maisie Skidmore
5 days ago from
It's Nice That
Ryan Pereira
Wave goodbye to your afternoon! Tumblr just launched its own GIF TV channel
Posted by Maisie Skidmore
10 days ago from
It's Nice That
Check out what Logo Design Love had to say about Hillary Clinton's campaign logo. Offers great advice into critiquing other designs.
Shared in Tools & Resources by Brandon Mooney
Video: AIGA Medalist Steve Frykholm
Santa Composição Portfolio
Santa Composição
claritygirl (rhonda page )
Take advantage of every chance to learn. "It is impossible to withhold education from the receptive mind." Agnes Repplier #AIGAdesign
An hour ago


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Despite Hurdles, Students Keep Switching Colleges
Persistence of transfers has "huge implications" for the growing number of states with performance-based funding, says an author of a new report on the 2008 cohort.
Nearly a Year Later, Fallout From Salaita Case Lingers on Campuses
The controversial scholar has secured another job. But colleges are still debating how to protect academic freedom when outrage goes viral.
In Assigning Group Work to Students, Designing the Group Comes First
Recent research shows that if teams and assignments are structured carelessly, they can be counterproductive.
Team Science Leaves Many Researchers Lost in the Crowd
It's hard to impress tenure committees when you're one author among thousands.
@AcademicsSay: The Story Behind a Social-Media Experiment
A parody Twitter account born out of frustration brought unexpected rewards — connecting with a previously unknown community and expanding research opportunities.
Louisiana State's Firing of Salty Professor Renews Worries About Faculty Rights
The university has drawn new scrutiny for dismissing a tenured instructor mainly for using obscene language and jokes around students.
- A Professor Crowdsources a Syllabus on the Charleston Shootings
- U. of Texas Campus Seeks to Retain Students Through Data and Personal Coaching
- A Professor, a Graduate Student, and 2 Careers Derailed
- Rachel Dolezal Case Leaves a Campus Bewildered and Some Scholars Disgusted
- Many Instructors Embrace Trigger Warnings, Despite Their Peers' Misgivings
The Week
What you need to know about the past seven days.
Colleges Face Calls for Better Support of Students With Learning Disabilities
More students with learning disabilities are heading to college and confronting new challenges. They can find help on campus, but the most supportive programs are rare.
New Players Could Be in Line to Receive Federal Student Aid
The Education Department is weighing a pilot project that would let students use Pell Grants at coding boot camps and other nontraditional programs.
When Admissions Interviews Get Weird
Sen. Ted Cruz says in his new memoir that he was hung over that day at Brown University. But, say admissions officers, that was tame compared with what they've seen.
Obama's Overtime Proposal Could Be Costly for Colleges
The proposal would make more workers eligible for overtime pay, and colleges would feel its impact. It's unclear, however, how many campus jobs might be affected.
- How Can You Tell When a College Is Circling the Drain?
- Guns, Prisons, Social Causes: New Fronts Emerge in Campus Fights Over Divestment
- U. of Phoenix Looks to Shrink Itself With New Admissions Requirements and Deep Cuts
- Self-Described 'Cannabis College' Sprouts Offshoots as More States Legalize Marijuana
- What to Expect as the Supreme Court Revisits Race in Admissions
Texas State Tech College Develops Skills Translator to Match Students With Jobs
The software helps align curricula with employers' needs, in part by making sure everyone's using the same terminology.
The Catch in Arizona State's Low-Cost Freshman Year Online: No Aid
The university's leaders acknowledge that federal rules prohibit the use of financial aid in the deal with edX. They also distance it from previous MOOCs.
How LinkedIn's Latest Move May Matter to Colleges
The professional-networking giant's purchase of Lynda.com could allow it to do to colleges what Airbnb has done to hotels and Uber has done to taxis.
Callisto to Offer New Reporting System for Survivors of Sexual Assault
The project, in development by a nonprofit organization, will use technology to bridge gaps in existing procedures. But some skeptics worry about protecting the accused.
Ed-Tech Entrepreneur Returns, Hoping to Connect Colleges and Start-Ups
Less than two years after being forced to sell most of his company, Paul Freedman is back on the scene with a new idea.
- Stanford Chief Wants Higher Ed to Be 'Affordable, Accessible, Adaptable'
- Cut Through the Hype, and MOOCs Still Have Had a Lasting Impact
- College IT Offices Sever Ties With Terrorist Acronym
- An Entrepreneur Sets Out to Do Better at Education Than His College Did
- As High-Tech Teaching Catches On, Students With Disabilities Can Be Left Behind


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General enquiries:
0300 555 0500
We are a locally managed and governed charitable housing association, based in Chelmsford, Essex, providing high-quality affordable family homes and apartments to rent and buy. We own approximately 8,500 homes across Essex.
25 June 2015
ONE of our residents will soon be embarking on a gentle stroll – by walking from Lands' End to John O'Groats (LeJoG).
08 June 2015
A NEW rural housing development in Ridgewell has been launched by James Cleverly in his role as the new MP for Braintree.
19 May 2015
TO mark the launch of Dementia Awareness Week (Monday 18th May to Saturday 23rd May), our charitable arm, CHP Foundations, is holding free Dementia Friends awareness sessions at the Parkside Community Hub in Melbourne Avenue, Chelmsford.
Last updated: 03 July 2015Back to top of page
You can view any of the publications on our website using Adobe Reader which can be downloaded for free.
Fancy trying something new and rewarding? Join us in helping out your local communities by becoming a volunteer. Please visit our volunteer pages for more information.
If you have seen or heard something in one of our properties that concerns you and needs to be dealt with by us, please Report a concern.


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In honor of St. Patrick's Day, we've gathered six sexy stars who've taken on the Irish accent onscreen. From Brad Pitt turning in two performances, to Colin Farrell calling upon his real-life accent, take a listen in this PopSugar special, and let us know who you think had the best (or worst) Irish accent!
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Colin Farrell
Tom Cruise
Entertainment Video
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Related Searches: antique wood farm wagon, antique farm wagon, wood wagon, toy farm wagons
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Fayetteville Newswire
Comprehensive Real-Time News Feed for Fayetteville, NC.
Results 1 - 2 of 2 for "u:wtvr.com" in Fayetteville, NC
NC man arrested after allegedly shooting out semia s tire on I-95 in Sussex w/Photo
A North Carolina man has been arrested after allegedly shooting out the tire of a tractor-trailer during a bizarre road rage incident on I-95 in Sussex County earlier this week. Virginia State Police said troopers were dissipated a shooting call along I-95 near the 32 mile marker in Sussex County just before 12:09 p.m. Wednesday after the drivers of a semi and a 2015 Subaru Outback were headed north "began engaging with one another." Comment?
Why this Virginia Marine volunteered to eat a scorpion w/Photo
BAN CHAN KREM, Thailand - So you want to be a Marine, eh? Cpl. Kyleigh M. Porter, from Montross, Virginia, was one of several Marines who took part in the Cobra Gold 2015 exercise this week in Ban Chan Krem, Thailand. Comment?
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25 Free Craft Projects for Every Crafter - The Ultimate Craft Guide
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Celebrate Green Video: Teapot Wall Vase
By: Corey Colwell-Lipson of Celebrate Green
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Corey Colwell-Lipson of Celebrate Green demonstrates how to create a pretty wall vase with a teapot. Use a dollar store teapot to create this wall vase as a unique, low-cost Mother's Day gift.
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Jun 02, 2010
Very clever idea! The Teapot Wall Vase video really helped me see how much fun the girls and guys would enjoy making these pieces of art for Ma, Aunts, Sis and even Dad with camo kick. :) Kat Kalama, WA
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NOW Foods NOW® Solutions Avocado Oil -- 4 fl oz
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Condition: Skin in need of hydration and increased elasticity.
Solution: 100% Pure Avocado Oil is an all-natural, nutrient-rich, food grade vegetable oil. heavy in texture, Avocado Oil increases epidermal elasticity, while thoroughly moisturizing and softening stubborn, dry or cracked skin. When used as a massage oil, it's soft, soothing and leaves no greasy residue.
NOW® Solutions is the next step in the evolution of personal care products. this comprehensive natural line encompasses anti-aging moisturizers and serums, bath and body gels, shampoos and conditioners, oral care, skin care, and essential oils, all of which are formulated with the finest functional ingredients from around the world. NOW® Solutions products avoid harsh chemicals and synthetic ingredients in the formulations, to provide a more natural product line.


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Related Searches: national guard ribbon, national defense ribbon, ribbon lot, satin ribbon
37 Results for National Guard Ribbon - For Sale Classifieds
New National Guard Components Achievement Ribbon With single ribbon bar holder. Similar to the one in the pictures1 month ago on ebay.com
This listing is for ONE ribbon. All ribbons are manufactured in the United States by a U.S. Government Authorized company to current government specifications. Ribbons are NEW and kept in a closed container in a non1 month ago on ebay.com
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Recent issue fullsize National Guard Medal with clutchback Ribbon Bar. SEE OTHER NATIONAL GUARD AND RELATED MEDALS IN MY OTHER LISTINGS.Today on ebay.com
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text: Heaven on earth... this place is spotless - right smack on the lake with breathtaking views and the most charming hotel rooms ever. I absolutely loved it. The owners are the ones who take care of the place and they are so efficient at it. We arrived at 9 pm (a party of 4 adults) and altho the kitchen was... More


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Earring - 2 Lt Semi Flush
Portables - 1 Lt Table Lamp
Grid™ - 1 Lt Pendant
Droplets™ - Mini Pendant
Chadbourne Collection - Four Light Pendant
Torii™ - 1 Lt Bath
Counter Weights - 6 Lt Low Voltage Chandelier
Aise Collection - Two Light Wall Sconce
1 Lt Wall Sconce
New Era - 52" Ceiling Fan
Magique Collection - Three Light Semi Flush
Chadbourne Collection - Eight Light- Two Tier Chandelier
9 Light Low Voltage Chandelier
Suspended - 4 Lt Pendant
Portables - 2 Lt Table Lamp
2 Lt Wall Sconce
Park™ - 1 Lt Table Lamp
Contractor - 52" Ceiling Fan
Pierce™ - Mini Pendant
George's Reading Room™ - Pharmacy Table Lamp
2 Light Wall Sconce
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Partner: UNT Libraries
Degree Discipline: Biochemistry
Degree Level: Doctoral
Collection: UNT Theses and Dissertations
Application of Synthetic Peptides as Substrates for Reversible Phosphorylation
Date: August 1992
Creator: Abukhalaf, Imad Kazem
Description: Two highly homologous synthetic peptides MLC(3-13) (K-R-A-K-A-K-T-TK-K-R-G) and MLC(5-13) (A-K-A-K-T-T-K-K-R-G) corresponding to the amino terminal amino acid sequence of smooth muscle myosin light chain were utilized as substrates for protein kinase C purified from murine lymphosarcoma tumors to determine the role of the primary amino acid sequence of protein kinase C substrates in defining the lipid (phosphatidyl serine and diacylglycerol) requirements for the activation of the enzyme. Removal of the basic residues lysine and arginine from the amino terminus of MLC(3-13) did not have a significant effect on the Ka value of diacylglycerol. The binding of effector to calcium-protein kinase C appears to be random since binding of one effector did not block the binding of the other.
Contributing Partner: UNT Libraries
Proteomic Responses in the Gill of Zebrafish Following Exposure to Ibuprofen and Naproxen
Date: August 2012
Creator: Adhikari, Prem R.
Description: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most abundant environmental pharmaceutical contaminants. In this study, a proteomic analysis was conducted to identify proteins differentially expressed in gill tissue of zebrafish (Danio rerio) after a 14-day exposure to the NSAIDs ibuprofen or naproxen. A total of 104 proteins with altered expression as indicated by 2-dimensional electrophoresis were analyzed by liquid chromatography with ion trap mass spectrometry (MS/MS). A total of 14 proteins fulfilled our requirements for identification which included consistency among replicate gels as well as successful MS/MS ion searches with the MASCOT database. The most prominent feature of the differential protein expression observed after NSAID exposure was an up-regulation of proteins belonging to the globin family which are involved in the transport of oxygen from gills and availability of heme molecules required for synthesis of cyclooxygenase. Differential expression was observed at exposure concentrations as low as 1-10 µg/L indicating that altered gene expression may occur in fish subjected to environmentally realistic levels of NSAID exposure.
Contributing Partner: UNT Libraries
Functional Characterization of Mtnip/latd's Biochemical and Biological Function
Date: December 2013
Creator: Bagchi, Rammyani
Description: Symbiotic nitrogen fixation occurs in plants harboring nitrogen-fixing bacteria within the plant tissue. The most widely studied association is between the legumes and rhizobia. In this relationship the plant (legumes) provides the bacteria (rhizobia) with reduced carbon derived from photosynthesis in exchange for reduced atmospheric nitrogen. This allows the plant to survive in soil, which is low in available of nitrogen. Rhizobia infect and enter plant root and reside in organs known as nodules. In the nodules the bacteria fix atmospheric nitrogen. The association between the legume, Medicago truncatula and the bacteria Sinorhizobium meliloti, has been studied in detail. Medicago mutants that have defects in nodulation help us understand the process of nitrogen fixation better. One such mutant is the Mtnip-1. Mtnip-1 plants respond to S. meliloti by producing abnormal nodules in which numerous aberrant infection threads are produced, with very rare rhizobial release into host plant cells. The mutant plant Mtnip-1 has an abnormal defense-like response in root nodules as well as defects in lateral root development. Three alleles of the Mtnip/latd mutants, Mtnip-1, Mtlatd and Mtnip-3 show different degrees of severity in their phenotype. Phylogenetic analysis showed that MtNIP/LATD encodes a protein belonging to the NRT1(PTR) family of ...
Contributing Partner: UNT Libraries
Kinetic and Chemical Mechanism of 6-phosphogluconate Dehydrogenase from Candida Utilis
Date: May 1993
Creator: Berdis, Anthony J. (Anthony Joseph)
Description: A complete initial velocity study of the 6-phosphogluconate dehydrogenase from Candida utilis in both reaction directions suggests a rapid equilibrium random kinetic mechanism with dead-end E:NADP:(ribulose 5-phosphate) and E:NADPH:(6- phosphogluconate) complexes. Initial velocity studies obtained as a function of pH and using NAD as the dinucleotide substrate for the reaction suggest that the 2'-phosphate is critical for productive binding of the dinucleotide substrate. Primary deuterium isotope effects using 3-<i-6-phosphogluconate were obtained for the 6-phosphogluconate dehydrogenase reaction using NADP and various alternative inucleotide substrates.
Contributing Partner: UNT Libraries
Function of the ENOD8 gene in nodules of Medicago truncatula.
Date: December 2006
Creator: Coque, Laurent
Description: To elaborate on the function(s) of the ENOD8 gene in the nodules of M. truncatula, several different experimental approaches were used. A census of the ENOD8 genes was first completed indicating that only ENOD8.1 (nt10554-12564 of GenBank AF463407) is highly expressed in nodule tissues. A maltose binding protein-ENOD8 fusion protein was made with an E. coli recombinant system. A variety of biochemical assays were undertaken with the MBP-ENOD8 recombinant protein expressed in E. coli, which did not yield the esterase activity observed for ENOD8 protein nodule fractions purified from M. sativa, tested on general esterase substrates, α-naphthyl acetate, and p-nitrophenylacetate. Attempts were also made to express ENOD8 in a Pichia pastoris system; no ENOD8 protein could be detected from Pichia pastoris strains which were transformed with the ENOD8 expression cassette. Additionally, it was shown that the ENOD8 protein can be recombinantly synthesized by Nicotiana benthamiana in a soluble form, which could be tested for activity toward esterase substrates, bearing resemblance to nodule compounds, such as the Nod factor. Transcription localization studies using an ENOD8 promoter gusA fusion indicated that ENOD8 is expressed in the bacteroid-invaded zone of the nodule. The ENOD8 protein was also detected in that same zone by ...
Contributing Partner: UNT Libraries
Manipulating Sucrose Proton Symporters to Understand Phloem Loading
Date: August 2013
Creator: Dasgupta, Kasturi
Description: Phloem vascular tissues transport sugars synthesized by photosynthesis in mature leaves by a process called phloem loading in source tissues and unloading in sink tissues. Phloem loading in source leaves is catalyzed by Suc/H+ symporters (SUTs) which are energized by proton motive force. In Arabidopsis the principal and perhaps exclusive SUT catalyzing phloem loading is AtSUC2. In mutant plants harboring a T-DNA insertion in each of the functional SUT-family members, only Atsuc2 mutants demonstrate overtly debilitated phloem transport. Analysis of a mutant allele (Atsuc2-4) of AtSUC2 with a T-DNA insertion in the second intron showed severely stunted phenotype similar to previously analyzed Atsuc2 null alleles. However unlike previous alleles Atsuc2-4 produced viable seeds. Analysis of phloem specific promoters showed that promoter expression was regulated by Suc concentration. Unlike AtSUC2p, heterologous promoter CoYMVp was not repressed under high Suc conc. Further analysis was conducted using CoYMVp to test the capacity of diverse clades in SUT-gene family for transferring Suc in planta in Atsuc2 - / - mutant background. AtSUC1 and ZmSUT1 from maize complemented Atsuc2 mutant plants to the highest level compared to all other transporters. Over-expression of the above SUTs in phloem showed enhanced Suc loading and transport, but against ...
Contributing Partner: UNT Libraries
Autophosphorylation and Autoactivation of an S6/H4 Kinase Isolated From Human Placenta
Date: May 1994
Creator: Dennis, Patrick B. (Patrick Brian)
Description: A number of protein kinases have been shown to undergo autophosphorylation, but few have demonstrated a coordinate increase or decrease in enzymatic activity as a result. Described here is a novel S6 kinase isolated from human placenta which autoactivates through autophosphorylation in vitro. This S6/H4 kinase, purified in an inactive state, was shown to be a protein of Mr of 60,000 as estimated by SDS-PAGE and could catalyze the phosphorylation of the synthetic peptide S6-21, the histone H4, and myelin basic protein. Mild digestion of the inactive S6/H4 kinase with trypsin was necessary, but not sufficient, to activate the kinase fully
Contributing Partner: UNT Libraries
Fluorescence labeling and computational analysis of the strut of myosin's 50 kDa cleft.
Date: August 2007
Creator: Gawalapu, Ravi Kumar
Description: In order to understand the structural changes in myosin S1, fluorescence polarization and computational dynamics simulations were used. Dynamics simulations on the S1 motor domain indicated that significant flexibility was present throughout the molecular model. The constrained opening versus closing of the 50 kDa cleft appeared to induce opposite directions of movement in the lever arm. A sequence called the "strut" which traverses the 50 kDa cleft and may play an important role in positioning the actomyosin binding interface during actin binding is thought to be intimately linked to distant structural changes in the myosin's nucleotide cleft and neck regions. To study the dynamics of the strut region, a method of fluorescent labeling of the strut was discovered using the dye CY3. CY3 served as a hydrophobic tag for purification by hydrophobic interaction chromatography which enabled the separation of labeled and unlabeled species of S1 including a fraction labeled specifically at the strut sequence. The high specificity of labeling was verified by proteolytic digestions, gel electrophoresis, and mass spectroscopy. Analysis of the labeled S1 by collisional quenching, fluorescence polarization, and actin-activated ATPase activity were consistent with predictions from structural models of the probe's location. Although the fluorescent intensity of the ...
Contributing Partner: UNT Libraries
Nucleotide Inhibition of Glyoxalase II
Date: May 1999
Creator: Gillis, Glen S
Description: The glyoxalase system mediates the conversion of methylglyoxal, a toxic ketoaldehyde, to D-lactic acid. The system is composed of two enzymes, glyoxalase I (Glo-I) and glyoxalase II (Glo-II), and exhibits an absolute requirement for a catalytic quantity of glutathione (GSH). Glo-I catalyzes the isomerization of a hemithioacetal, formed non-enzymatically from methylglyoxal and GSH, to the corresponding a -D-hydroxyacid thioester, s-D-lactoylglutathione (SLG). Glo-II catalyzes the irreversible breakdown of SLG to D-lactate and GSH. We have observed that ATP or GTP significantly inhibits the Glo-II activity of tissue homogenates from various sources. We have developed a rapid, one step chromatography procedure to purify Glo-II such that the purified enzyme remains "sensitive" to inhibition by ATP or GTP (Glo-II-s). Studies indicate that inhibition of Glo-II-s by nucleotides is restricted to ATP, GTP, ADP, and GDP, with ATP appearing most effective. Kinetics studies have shown that ATP acts as a partial non-competitive inhibitor of Glo-II-s activity, and further suggest that two kinetically distinguishable forms of the enzyme exist. The sensitivity of pure Glo-II-s to nucleotide inhibition is slowly lost on storage even at -80° C. This loss is accelerated at higher temperatures or in the presence of ATP. Kinetics studies on the resultant "insensitive" ...
Contributing Partner: UNT Libraries
Plastidial carbonic anhydrase in cotton (Gossypium hirsutum L.): characterization, expression, and role in lipid biosynthesis
Date: August 2001
Creator: Hoang, Chau V.
Description: Recently, plastidial carbonic anhydrase (CA, EC 22.214.171.124) cDNA clones encoding functional CA enzymes were isolated from a nonphotosynthetic cotton tissue. The role of CA in photosynthetic tissues have been well characterized, however there is almost no information for the role of CA in nonphotosynthetic tissues. A survey of relative CA transcript abundance and enzyme activity in different cotton organs revealed that there was substantial CA expression in cotyledons of seedlings and embryos, both nonphotosynthetic tissues. To gain insight into the role(s) of CA, I examined CA expression in cotyledons of seedlings during post-germinative growth at different environmental conditions. CA expression in cotyledons of seedlings increased from 18 h to 72 h after germination in the dark. Seedlings exposed to light had about a 2-fold increase in CA activities when compared with seedlings kept in the dark, whereas relative CA transcript levels were essentially the same. Manipulation of external CO2 environments [zero, ambient (350 ppm), or high (1000 ppm)] modulated coordinately the relative transcript abundance of CA (and rbcS) in cotyledons, but did not affect enzyme activities. On the other hand, regardless of the external CO2 conditions seedlings exposed to light exhibited increase CA activity, concomitant with Rubisco activity and increased ...
Contributing Partner: UNT Libraries


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Oshkosh North one win from state again
11:58 PM, Mar. 1, 2013
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Oshkosh North one win from state again
The Oshkosh North Spartans boys basketball teams might get the feeling of deja vu when they walk into Stevens Point High School today at 2 p.m. That?s because it?s the same venue, same stakes and
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2 items from 2015
18 May 2015 3:30 PM, PDT | E! Online | See recent E! Online news »
American Crime Story: The People v. O.J. Simpson just added two more faces to its already star-studded cast! E! News has learned that Cheryl Ladd and Evan Handler have joined the cast of Ryan Murphy's new FX miniseries taking a look at the now-infamous O.J. Simpson trial told from the perspective of the lawyers. But who are they playing? Ladd, one of the original Charlie's Angels, will play Linell Shapiro, the wife of O.J. Simpson defense attorney Robert Shapiro, while Handler, best known for his role on Sex and the City and who can next be seen in ABC's new 10-episode limited series Astronaut Wives Club, is playing attorney Alan Dershowitz, another member of O.J.'s "Dream Team." Ladd »
7 April 2015 4:15 AM, PDT | TMZ | See recent TMZ news »
Former "Charlie's Angels" star Jaclyn Smith may have hung up her gun garter but she's still smokin' ... at 69 years old! Smith -- who will turn 70 in October -- was out shopping in Beverly Hills on Monday ... and it's obvious SoCal living has been Very good to her. We'd say the 70s and 80s sex symbol should bottle her beauty secrets and sell them, but she already has. Jaclyn's a bonafide mogul who's made Millions off her home and beauty products. »
- TMZ Staff
2 items from 2015
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Is Tom Clancy's Rainbow Six: Patriots dead? We're not sure, but GameStop made a dramatic move today that might indicate that something bad has happened to Ubisoft's upcoming game. According to IGN, video game retailer GameStop has removed the game from its database, and is no longer available for pre-order.
As detailed in this May 7 story, indie studio Notion Games indicated that Ubisoft had asked it to change the name of its game Super Ubi Land to something else to avoid the implication that the game was somehow associated with the French publisher. At the time Notion Games said that it would do just that and that it understood where Ubisoft was coming from.
At a recent Ubisoft press event to promote its upcoming game Watch Dogs, senior producer Dominic Guay revealed how the company is working hard to make the hacking in the game as authentic as humanly possible. Joystiq covered the press event extensively in this article.
Indie game developer Notion Games announced via Twitter that it will change the name of its game, Super Ubi Land, following concerns expressed by Ubisoft over potential confusion and possible brand infringement. Super Ubi Land has no connection to Ubisoft, obviously.
The game was announced in January and successfully raised $6,333 from nearly 300 backers in February on Kickstarter.
The game is being developed for Wii U, Windows PC, Mac and Linux for release later this year.
According to this Gameranx report some hackers in Russia are already playing Far Cry 3: Blood Dragon, despite the fact that it isn't quite out yet. Apparently a group of Russian hackers have discovered an exploit in Ubisoft's uPlay digital distribution service that allows them to download the game without paying for it.
In response to a statement from the People for the Ethical Treatment of Animals (PETA) earlier in the week about whaling in Assassin's Creed.
As it is wont to do sometimes People for the Ethical Treatment of Animals (PETA) is targeting another video game for its depiction of cruelty towards animals, though this time it was induced to do so by GamesBeat who asked the organization for its comment. While I can assure PETA that no animals were harmed in the making of this video game, the organization sometimes has trouble differentiating between what is real and what is not (video games, for example).
Speaking to MCV recently Ubisoft CEO Yves Guillemot stated the obvious: the Wii U needs to sell more units. The topic came up because Guillemot was talking about all the resources his company has green lighted for Ubisoft Montreal - the studio developing Watch Dogs. That game will also be coming to the Wii U, amongst other platforms.
"We think Wii U is a great machine. But it just has to sell more," Guillemot said.
In an interview with MCV Ubisoft's worldwide Uplay director Stephanie Perotti acknowledges that the company doesn't have the best relationship with the PC gaming community because of past issues (namely its strong support for "always on DRM" in several of its major PC titles), but that the company is listening to the feedback and reacting accordingly - most notably getting rid of its much-hated DRM-scheme.
It's not an evil alliance, but some (those that don't like Uplay and Origin) might view it that way. It looks like Uplay and Origin are doing a little foreign exchange action, with Ubisoft's digital distribution platform getting select EA titles and EA's digital distribution platform getting games from Ubisoft. Ubisoft's Uplay service is also offering games from other third-party publishers including Warner Bros., Focus Home Interactive, Freebird Games, Paradox Interactive, Telltale Games and more.
Rayman creator Michel Ancel and staff members from Ubisoft Montpellier have joined fans in protesting the delayed release of Rayman Legends on the Wii U in order to simultaneously release the former Wii U exclusive on the PS3 and Xbox 360. Apparently the Wii U version is ready to go, but parent company Ubisoft wants to keep it locked down until the other versions of the game are done. Our pal Andrew Eisen shared his thoughts on that yesterday in this amusing video...
Look! It's a new video with Andrew Eisen complaining about something. There's no keeping this guy satisfied! Not only is he upset with the delay of Rayman Legends for all platforms (hey, wasn't this supposed to be a Wii U exclusive?), but he also wants to make us listen to him complaining about it. I'm sure he uses some kind of rapier wit to describe his current angst against Ubisoft (usually he'd be complaining about U Play or "always on" DRM), but will it make his message palatable enough for us to listen? The jury is still out.
Ubisoft announced that it has shipped well over 12 million units of Assassin's Creed 3 and well over 4.5 million units of Far Cry 3. That number includes all platforms the games are available on - as well as digital sales of both games. Ubisoft's total sales for Assassin's Creed 3 have now passed the 12 million mark worldwide, while Far Cry 3 sales are up over 4.5 million units, the French publisher announced today in its third-quarter financial report.
To paraphrase that Fresh Prince song, "there's no need to argue gamers just don't understand..." the Wii U. So says Xavier Poix, Managing Director of Ubisoft's Annecy, Montpellier, and Paris studios. Speaking to GameSpot, Poix says that the reason the Wii U has had such a slow start is that gamers don't get what the system is really capable of.
A torture mechanic in Splinter Cell: Blacklist has been removed following a negative reaction (according to GameSpot based on a Eurogamer report). The gameplay mechanic let Sam Fisher drive a knife into an enemy's clavicle in an attempt to extract information. During the scene players can press a button to twist the knife as a means to get the information that want from the target.
According to an MCV report, Ubisoft is considering buying troubled games publisher THQ. Earlier in the week the publisher announced that it had filed for bankruptcy and would be sold to Clearlake investments. This 'stalking horse bid' process with the investor allows THQ to write off the company's debts but keeps its business going to make it ready for an acquisition. According to MCV one of the companies that might be interested in buying THQ is Ubisoft.
No matter what you think of Uplay (PC gamers know it as a future digital distribution platform and as facilitator of horrible always-on DRM masquerading as something else - particularly for PC gamers), what Ubisoft is trying to do with it on Wii U is interesting because it adds a number of features to its games on the platform.
Ubisoft is apologizing to Far Cry 3 players for issues with the company's Uplay online gaming service. Some players have reported that they were unable to play the game because of Uplay server issues. Apparently setting the Uplay client to offline mode allows players to play part of the game, according to Rock, Paper, Shotgun.
Ubisoft says that when Far Cry 3 is released on PC in Europe and North America, players will have to download what they categorize as a "critical" day-one patch for the game. The version 1.01 patch fixes a number of single and multiplayer bugs, promises improved stability and performance in multiplayer, adds options to the game's online leaderboard, fixes a voice chat issue that mutes players by default, fixes graphical issues on loading screen hints, and a bug that prevents maps from showing up the first time a user enters Public co-op play.
With the Wii U launch less than a week away, many game publishers have strong opinions about Nintendo's newest platform. In an upcoming interview with GamesIndustry International, CEO Yves Guillemot offers his. While Ubisoft is one of the biggest third-party supporter of Wii U at launch, the company's CEO Yves Guillemot acknowledges that Nintendo may have to lower the price of the console.
Ubisoft says that everyone who bought Assassin's Creed 3 should download the "day-one patch" because it "optimizes player experience and is highly recommended." Not exactly an inspiring message for a product that you just bought. The day-one patch fixes bugs and other glitches that shipped with the game, apparently. Ubisoft has a list of fixes here in the patch notes, but you probably won't want to read it because it is chock-full of spoilers.
Earlier in the month Ubisoft announced that it would turn its Uplay game community hub into a digital distribution platform, and with last week's news that it had toned down its DRM scheme for PC releases, today's news is really a no brainer. The company said today that - at some point - it would like to bring third-party titles to the platform.
E. Zachary Knight makes a triumphant return in Episode 19 of the Super Podcast Action Committee. After a near-death experience (we might be slightly exaggerating) last week, he rejoins host Andrew Eisen to discuss getting older (be sure to wish him a happy birthday today!) Steam Greenlight's early hurdles, the latest GamePolitics poll, and Ubisoft's new DRM policy. Download it here: SuperPAC Episode 19 (57 Minutes).
An interview with Chris Early, vice president of digital publishing at Ubisoft, and another interview with Ubisoft's Stephanie Perotti reveals that the company is finally starting to turn the corner on its "always-on" DRM schemes for PC games.
The last time we reported on Ubisoft's Uplay, the company was denying that its program installed a rootkit on consumers' computers. From that media buzz, the company thought it would be a great time to announce that it is rolling out Uplay as a full-fledged digital distribution platform not unlike Steam or Origin.
Ubisoft calls yesterday's story about a rootkit being found in Uplay false and blames "a coding error" for the security hole. Ubisoft denied the whole "rootkit" angle altogether. After quickly patching the Uplay software yesterday, the company issued a statement saying that a coding error was the cause of the software being able to launch any executable on a remote computer - a fact hackers demonstrated as a proof of concept this week.


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This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
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"The owner attention is superb. The apartment is fantastic and the location incredible. I do recommend it with no doubt. Amazing!!!!!"Guest: Patricia Date of Stay: July 2014 Review Submitted: October 9, 2014View listing
Featured Destinations: The Villages, Rosemary Beach, Destin Condo Rentals, Amelia Island, Myrtle Beach, Outer Banks


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qingdao yiming plastic machinery co.,ltd
plastic machinery, plastic pipe machinery, pvc pipe machinery, pvc pipe extruder, pe pipe machinery, Manufacturer and Supplier - China
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The raw matorial of the plastic corrugation pipe is HDPE, resisting corrosive, acid and alkali, preventing the prestressing muscle from boing eroded. Many prestressing structure suffor severe influence from environment, such as deice salt or brine. M... - Update: 2010-06-26
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Alex Gibney to Direct HBO's Frank Sinatra Documentary
The "We Steal Secrets: The Story of Wikileaks" helmer takes on the four-hour miniseries, featuring never-before-seen industry footage and home movies.
Alex Gibney (We Steal Secrets: The Story of Wikileaks) will direct a four-hour documentary miniseries on Frank Sinatra for HBO -- what its producers call an "up close and personal examination" of the legendary singer and actor, Alcon Television president Sharon Hall said Tuesday.
The documentary will cover Sinatra's life, music and career, drawing on industry footage and home movies, some of which has never been publicly seen, as well as private and public performances.
"Alex's vision for this unique documentary is an exciting one," says Hall, "taking viewers into the singular and extraordinary world created by one of the greatest entertainers the world has ever known."
Producers include daughter Nancy Sinatra and Frank Sinatra Enterprises, a joint venture of the Sinatra family and Warner Music Group.
The production team also includes the Alcon Television Group, Kennedy-Marshall Co. and Jigsaw Productions. Jeff Pollack will also serve as a producer. Executive producers, besides Nancy Sinatra, are Frank Marshall, Charles Pignone, Hall and Alcon co-CEOs Broderick Johnson and Andrew Kosove.
"Although our primary business at Alcon Television is to develop, finance and produce scripted series for broadcast and cable television," added Hall, "we were overwhelmed by the scope and depth of this incredible story, not to mention the opportunity to work with Alex and to partner with Kennedy-Marshall and Frank Sinatra Enterprises, on what is surely to be the definitive portrait of our era's greatest performer."
Gibney won an Academy Award for his 2007 documentary Taxi to the Dark Side. His most recent doc is Focus Features' Wikileaks movie.
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Format Maps
Results 1 - 1 of 1
Refined by:Original Format: Maps Remove Location: North America Remove Sites and Collection: Additional Conservation and Environment Cartographic Items Remove Contributor: Jansson, Jan Remove
Nova Anglia, Novvm Belgivm et Virginia.
Available also through the Library of Congress web site as a raster image.
- Contributor: Jansson, Jan
- Original Format: Maps
- Date: 1642


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News Releases
June 03, 2015Virginia Tourism Revenues Expected to Exceed $22.4 Billion in 2014
Governor Terry McAuliffe announced today that Virginia's tourism revenues are expected to exceed $22.4 billion in 2014, a 4.1 percent increase over 2013.
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June 01, 2015Virginia Launches #VAOutdoors Instagram Campaign
Virginia Tourism Corporation aims to mobilize Instagrammers during Great Outdoors Month with a series of challenges each Wednesday in June.
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May 27, 2015Virginia Tourism Partners with Virginia Department of Alcoholic Beverage Control to Promote Virginia Products
Virginia Tourism is partnering with Virginia Department of Alcoholic Beverage Control, using the 46-year-old Virginia is for Lovers logo to promote the assortment of alcoholic products made in the Commonwealth.
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May 14, 2015Virginia Invites Stars of Popular YouTube Show Sorted Food to Get #LostAndHungry
Virginians are taking to social media to invite the stars of the popular YouTube show Sorted Food to get "Lost & Hungry" here in the Commonwealth.
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May 07, 2015Celebrate Virginia Business Appreciation Month: Craft Beer is Big Business in Virginia
On April 30, 2015, Governor McAuliffe declared May as Business Appreciation Month in Virginia. As the 9th most visited state in the country, Virginia's tourism industry is big business for the Commonwealth. In 2013, visitors spent $21.5 billion, which supported 213,000 jobs and contributed $1.42 billion in state and local taxes. Tourism is an instant revenue generator.
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