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Lab 2 - Analysis of Affymetrix Microarray Data James Wettenhall. Created June 25, 2004. Updated July 2, 2004. Contents: 1. Software required for this lab 1. Required R packages 2. Recommended R packages 3. Required data files 2. Estrogen data set 3. Analyzing the data in R 1. Loading the affy package and finding the Estrogen data 2. Preparing the RNA Targets file 3. Reading the targets file and the CEL files into R 4. Diagnostic plots 1. Image plots 2. Histograms 3. M A plots (using raw unnormalized data) 5. Normalization 1. RMA (Robust Multichip Averaging) 2. Examining the effects of normalization using boxplots 3. PLM (Probe-level linear models) 4. GCRMA (Using DNA sequence information to improve RMA) 6. More diagnostic plots 1. M A plots (using normalized data) 7. Saving your R workspace 4. Memory Troubles? 5. Acknowledgements 6. References 7. Glossary 1. Software required for this lab. You will need R 1.9.0 or later (http://www.R-Project.org) for this lab exercise. This section lists all of the R packages you need to have installed and also lists some additional R packages which are recommended. Note that most of the R packages can be installed from the Bioconductor site automatically using: source("http://www.bioconductor.org/getBioC.R") getBioC(). 1.1 Required R packages It is highly desirable to have these R packages in a directory in which you have write permission, especially for the estrogen package. You can use .libPaths("C:/Custom/R/library/directory") or .libPaths("C:\\Custom\\R\\library\\directory") before you run install.packages() (or equivalent) to install the package(s) in a customized directory location. Package URL http://www.bioconductor.org/repository/release1.4/package/html/affy.htm affy l http://www.bioconductor.org/repository/release1.4/package/html/Biobase. Biobase html estrogen http://www.bioconductor.org/data/experimental.html hgu95av2cdf http://www.bioconductor.org/data/metaData.html http://www.bioconductor.org/repository/release1.4/package/html/affyPL affyPLM M.html http://www.bioconductor.org/repository/release1.4/package/html/affydata affydata .html http://www.bioconductor.org/repository/release1.4/package/html/gcrma.h gcrma tml http://www.bioconductor.org/repository/release1.4/package/html/matchpr matchprobes obes.html hgu95av2prob http://www.bioconductor.org/data/metaData.html es 1.2 Recommended R packages Package URL hgu95av2 http://www.bioconductor.org/data/metaData.html http://www.bioconductor.org/repository/release1.4/package/html/reposTools. reposTools html widgetTool http://www.bioconductor.org/repository/release1.4/package/html/widgetTool s s.html http://www.bioconductor.org/repository/release1.4/package/html/DynDoc.ht DynDoc ml http://www.bioconductor.org/repository/release1.4/package/html/tkWidgets. tkWidgets html 1.3 Required data files The Estrogen data set is listed in the Required R packages section. There is one additional file which you should obtain, EstrogenTargets.txt. Data URL EstrogenTargets.txt http://bioinf.wehi.edu.au/marray/ibc2004/lab2/EstrogenTargets.txt 2. Estrogen data set For this lab, we will use data from a set of eight Affymetrix chips from a 2x2 factorial- design experiment designed to measure changes in gene expression in a breast-cancer cell line due to the presence (or absence) of estrogen and due to a time effect (10 hours or 48 hours). The experiment was performed by Scholtens et. al [1] who have kindly provided their data for public access on the Bioconductor website: http://www.bioconductor.org/data/experimental.html. The Estrogen data is stored in the "data" subdirectory of an R package called "estrogen" which is listed on this website. It can be installed like any other R package, then the data can be found from within R in the directory: system.file("data",package="estrogen"). This data set is described in detail in the "Estrogen 2x2 Factorial Design" vignette by Denise Scholtens and Robert Gentleman [2]. The following description of the experiment is taken from that vignette. Experimental Data "The investigators in this experiment were interested in the effect of estrogen on the genes in ER+ breast cancer cells over time. After serum starvation of all eight samples, they exposed four samples to estrogen, and then measured mRNA transcript abundance after 10 hours for two samples and 48 hours for the other two. They left the remaining four samples untreated, and measured mRNA transcript abundance at 10 hours for two samples, and 48 hours for the other two. Since there are two factors in this experiment (estrogen and time), each at two levels (present or absent,10 hours or 48 hours), this experiment is said to have a 2x2 factorial design." The table below describes the experimental conditions for each of the eight arrays. When stored as tab-delimited text, this is known as the RNA Targets file. Name FileName Target Abs10.1 low10-1.cel EstAbsent10 Abs10.2 low10-2.cel EstAbsent10 Pres10.1 high10-1.cel EstPresent10 Pres10.2 high10-2.cel EstPresent10 Abs48.1 low48-1.cel EstAbsent48 Abs48.2 low48-2.cel EstAbsent48 Pres48.1 high48-1.cel EstPresent48 Pres48.2 high48-2.cel EstPresent48 The file (shown as a table above) is known as the "RNA Targets" file in limma or in affylmGUI. It should be stored in tab-delimited text format and it can be created either in a spreadsheet program (such as Excel) or in a text editor. The column headings must appear exactly as above. Each chip should be given a unique name or number (in the Name column). The Affymetrix CEL file name should be listed for each chip in in the FileName column. The Target column tells limma or affylmGUI which chips are replicates. By using the same "Target" name for the first two rows in the table, we are telling limma or affylmGUI that these two CEL files represent replicatechips for the experimental condition (Estrogen Absent, Time 10 hours). Note that we could use a different Targets file for this analysis in which the time effect was ignored if we only wanted to compare Estrogen Absent and Estrogen Present. This would simply require removing the 10's and 48's from the Target column. There is actually a file called "phenoData.txt" supplied within the estrogen package, which could be used as a Targets file, but in this exercise you should use the format above or download "EstrogenTargets.txt" from http://bioinf.wehi.edu.au/marray/ibc2004/lab2/EstrogenTargets.txt. This way is simpler because we describe the type of RNA target in just one column (Target), rather than in two columns (estrogen and time.h). 3. Analyzing the data in R 3.1 Loading the affy package and finding the Estrogen data Firstly, load the affy package (which automatically loads Biobase) and set your working directory to the "data" subdirectory of the estrogen package. library(affy) setwd(system.file("data",package="estrogen")) dir() getwd() There is documentation available in the doc subdirectory of the affy package. To find this directory on your computer, you can use: system.file("doc",package="affy") from within R. Alternatively, you can read the latest version of the documentation on the Internet (Gautier et al. [3]). 3.2 Preparing the RNA Targets file If you are connected to the Internet, you can download the Estrogen targets file using the download.file function below. If you are not connected to the Internet and you do not have the file already, you can create it in Excel from the table in section 2 and save it as tab-delimited text in the directory given by getwd() above. If you have ignored the advice in Section 2 and installed the estrogen package in a directory where you don't have write permission, you will need to store "EstrogenTargets.txt" somewhere else. download.file("http://bioinf.wehi.edu.au/marray/ibc2004/lab2/EstrogenTar gets.txt","EstrogenTargets.txt") 3.3 Reading the targets file and the CEL files into R pd <- read.phenoData("EstrogenTargets.txt",header=TRUE,row.names=1,as.is=TRUE) rawAffyData <- ReadAffy(filenames=pData(pd)$FileName,phenoData=pd) rawAffyData "rawAffyData" is an S4 object of class "AffyBatch". By typing the name of the object and pressing enter, we are invoking the "show" method for objects of this class. To see the R code for this "show" method, you can type: getMethod("show","AffyBatch"). To see R code for the "show" method when applied to other types of objects, you can type: getMethods("show"). 3.4 Diagnostic plots 3.4.1 Image plots We can check the quality of the arrays using image plots and histograms of the log intensities. Firstly, let's look at images of the first two arrays. image(rawAffyData[,1]) image(rawAffyData[,2]) No spatial artefacts are apparent in the first two estrogen arrays, but we do have an example of a CEL file with a bad spatial artefact: badcel <- ReadAffy(file="bad.cel") # 'file' is short for 'filenames' image(badcel) To see the R code for the image method for objects of class AffyBatch, use: getMethod("image","AffyBatch") 3.4.2 Histograms Another diagnostic plot which may be useful is a histogram of the PM (Perfect Match) log intensities or the MM (MisMatch) log intensities. The R commands below each plot a histogram of log2 intensities for the first Estrogen microarray chip. The first command includes only the PM probes in the histogram, whereas the second command includes only the MM probes. hist(log2(pm(rawAffyData[,1])), breaks=100, col="blue") hist(log2(mm(rawAffyData[,1])), breaks=100, col="blue") 3.4.3 M A Plots (using raw unnormalized data) In Lab 1, M A plots were used to compare the two channels on each array (red and green), whereas for Affymetrix chips, there is only one channel on each array, so the only meaningful way to define M (the log ratio) is to compare different chips. We have 8 chips, so there are 8C2 = 28 possible comparisons which is quite a lot considering that we are dealing with probe-level data. Instead of making all possible comparisons, we will ignore the replicate chips (2, 4, 6 and 8) and just use (1,3,5 and 7). We will use the PM (Perfect Match) probes to calculate log ratios (M) and log intensities (A). The function mva.pairs in the affy package can be used for M versus A plots, where M is a log ratio (in base 2) and A is an average log intensity (in base 2). mva.pairs(pm(rawAffyData)[,c(1,3,5,7)]) It is clear from these plots that there is a significant time effect, i.e. each M A plot comparing time 10 hours with time 48 hours is not centred at M = 0. The reader should be aware that the normalization will remove this effect, because normalization generally assumes that the majority of genes are not differentially expressed. The experimenters felt that there was no possible biological reason why EVERY gene on the chip would be expressed so differently at the later time (48 hours), and that it must be an artefact due to the microarray technology. Therefore, there it seems reasonable to use the traditional normalization methods. 3.5 Normalization There are several normalization methods available for Affymetrix data. For a detailed comparison, see Bolstad et al. [4]. MAS 5.0 ([5]) is a method distributed in the MicroArray Suite (version 5.0) by Affymetrix. This method is available in the affy package for R, but may give slightly different results from the Affymetrix software (Bolstad [6]). We will not use MAS 5.0 in this lab exercise. Instead, we will use RMA (Robust Multichip Averaging) (Irizarry et al. [7]) and PLM (Probe-level Linear Model fits). 3.5.1 RMA (Robust Multichip Averaging) Normalize the Estrogen data using the rma function, which will create an object of class exprSet. In order to run rma on the Estrogen data, you must either have the CDF (Chip Definition File) package hgu95av2cdf installed or have reposTools installed and be connected to the Internet for automatic download of the CDF package by the rma() function. eset <- rma(rawAffyData) eset "eset" is an S4 object of class "exprSet". By typing the name of the object and pressing enter, we are invoking the "show" method for objects of this class. To see the R code for this "show" method, you can type: getMethod("show","exprSet"). To see R code for the "show" method when applied to other types of objects, you can type: getMethods("show") 3.5.2 Examining the effects of normalization using boxplots # Before RMA normalization: boxplot(rawAffyData,col="red") # After RMA normalization: boxplot(data.frame(exprs(eset)),col="blue") Note the considerable effect of normalization on this data set! The intensity values in these boxplots have been transformed to a log2 scale. To confirm this for yourself, see: getMethod("boxplot","AffyBatch") and ?rma 3.5.3 PLM (Probe-level linear models) Probe-level Linear Models can be used as a more robust alternative to RMA normalization. The provide a matrix of weights for each chip which can be used for another type of diagnostic image plot. Officially, the affyPLM package depends on the affydata package, but it should not be required for the simple use of affyPLM illustrated below. Load the affyPLM package and create an object of class PLMset using the fitPLM function. library(affyPLM) plmset <- fitPLM(rawAffyData) plmset There is documentation available in the doc subdirectory of the affyPLM package. To find this directory on your computer, you can use: system.file("doc",package="affyPLM") from within R. Alternatively, you can read the latest version of the documentation on the Internet (Bolstad. [8]). Now create image plots (used to diagnose spatial artefacts) for the first two chips and compare them with the image plots you obtained in section 3.3.1. image(plmset,1) image(plmset,2) If you are connected to the web, you can have a look at Ben Bolstad's affyPLM image gallery: browseURL("http://www.stat.berkeley.edu/~bolstad/PLMImageGallery/") 3.5.4 GCRMA (Using DNA sequence information to improve RMA) DNA sequences are made up of four bases (nucleotides), called A, C, G and T. In double- stranded DNA, A is always opposite T and C is always opposite G. Each G-C pair has three hydrogen bonds between the G and the C, whereas each A-T pair has only two hydrogen bonds between the A and the T. It is for this reason that biologists are interested in the "GC content" of certain areas of the genome. RNA is single stranded and is generally created by transcribing (copying) DNA, with the only difference in sequence being that T is replaced by U. In microarray hybridizations, the probes printed on the chip are single-stranded cDNA (reverse-transcribed from RNA), but the target RNA contains the bases A, C, G and U, rather than A, C, G and T, so it is possible to get both A-T pairs and A-U pairs in the hybridizations. The A-U pairs have the same properties as the A-T pairs in double-stranded DNA, i.e. only two hydrogen bonds, so the idea of "GC content" is just as relevant to microarray hybridizations as it is to double-stranded DNA molecules. The gcrma package takes GC content into account when doing RMA normalization. The gcrma package requires the matchprobes package and a probes package for the Affymetrix chip being used. In this case the probes package required is hgu95av2probes. Load the gcrma package and normalize the data in the same way as you did with RMA. library(gcrma) esetGCRMA <- gcrma(rawAffyData) esetGCRMA There is documentation available in the doc subdirectory of the gcrma package. To find this directory on your computer, you can use: system.file("doc",package="gcrma") from within R. Alternatively, you can read the latest version of the documentation on the Internet (Wu and Irizarry [9]). 3.6 More diagnostic plots 3.6.1 M A Plots (using normalized data) After creating an expression set object eset in Section 3.5.1, you can now replot the M A plots from Section 3.4.3, this time using normalized expression values. These plots will appear more quickly because they don't require probe-level data. For the sake of comparison with Section 3.4.3, we will again only use chips 1,3,5 and 7. The function mva.pairs in the affy package can be used for M versus A plots, where M is a log ratio (in base 2) and A is an average log intensity (in base 2). mva.pairs(exprs(eset)[,c(1,3,5,7)],log.it=FALSE) As described in Section 3.4.3, the normalization removes a time effect in this case, but the experimenters felt certain that there was no possible biological effect which can change the expression level of EVERY gene so dramatically. It is therefore reasonable to assume that this effect is due to different calibrations of the microarray technology, and should therefore be removed by normalization. The reason that we specify log.it=FALSE in mva.pairs is that the expression measurements in eset have already been log-transformed. (See the help for rma, using ?rma). 3.7 Saving your R workspace Please save your R workspace with: save.image("estrogen.RData") so that you can use the exprSet object(s) you have created in Lab 3. 4. Memory Troubles? Most of the exercises in this lab can be done with 512 Megabytes of RAM, except for affyPLM (Section 3.5.3) and gcrma Section 3.5.4, which require 1 Gigabyte of RAM. If you have less than 512 Megabytes of RAM, you will not be able to do any probe-level analysis (i.e. anything which involves "rawAffyData") on the full set of 8 chips, but you can use the function justRMA() from the affy package to read in your data from CEL files and then normalize it without creating a rawAffyData object (of class AffyBatch). Alternatively, you can try reading in only a subset of the arrays, but you will need to have some replicate arrays for Lab 3, i.e. for Lab 3, you can't just use arrays 1, 3, 5 and 7. If you experience memory errors, please restart your R session before trying a less memory-expensive alternative. The following function justRMA() should read in all 8 arrays, normalize them, and create an object of class exprSet with as little as 128 Megabytes of RAM: library(affy) setwd(system.file("data",package="estrogen")) pd <- read.phenoData("EstrogenTargets.txt",header=TRUE,row.names=1,as.is=TRUE) eset <- justRMA(filenames=pData(pd)$FileName,phenoData=pd) eset Or to read in only the first four arrays, you can use: eset <- justRMA(filenames=pData(pd)$FileName[1:4],phenoData=pd) eset 5. Acknowledgements Thanks to Scholtens et al. [1] for providing the Estrogen data on the Bioconductor site (http://www.bioconductor.org/data/experimental.html). Thanks also to Robert Gentleman and Wolfgang Huber for the vignette in the estrogen package which this lab was based on. Thanks also to Sandrine Dudoit, Robert Gentleman, Rafael Irizarry, and Yee Hwa Yang for the DNA Microarray Data and Oligonucleotide Arrays talk slides from the Bioconductor Short Course at DSC 2003 in Vienna (http://www.bioconductor.org/workshops/Vienna03). These talk slides were used to create the glossary (below). 6. References 1. Scholtens D, Miron A, Merchant FM, Miller A, Miron PL, Iglehart JD, Gentleman R. Analyzing Factorial Designed Microarray Experiments. Journal of Multivariate Analysis. To appear. 2. Scholtens D, Gentleman R. Estrogen 2x2 Factorial Design. http://www.bioconductor.org/repository/devel/vignette/factDesign.pdf 3. Gautier L, Irizarry R, Cope L and Bolstad B. Description of Affy. http://www.bioconductor.org/repository/devel/vignette/affy.pdf (*) 4. Bolstad, B. M., Irizarry, R. A., Astrand, M., and Speed, T. P., A comparison of normalization methods for high density oligonucleotide array data based on variance and bias, Bioinformatics, 19, 185 (2003). 5. The MAS 5.0 User Manual http://www.affymetrix.com/Auth/support/downloads/manuals/mas_manual.zip 6. Bolstad B. Why do my MAS 5.0 values differ? http://stat- www.berkeley.edu/~bolstad/MAS5diff/Mas5difference.html 7. Irizarry, R. A., Hobbs, B., Collin, F., Beazer-Barclay, Y. D., Antonellis, K. J., Scherf, U., and Speed, T. P. (2003). Exploration, normalization and summaries of high density oligonucleotide array probe level data. Biostatistics 4, 249-264. 4/2003 8. Bolstad B. affyPLM: Methods for fitting probe level models to Affy data. http://www.bioconductor.org/repository/devel/vignette/affyPLM.pdf (*) 9. Wu A, Irizarry R. Description of gcrma. http://www.bioconductor.org/repository/devel/vignette/gcrma.pdf (*) (*) These documents are also available within the doc/ subdirectory of these R packages, which can be found from within R, using: system.file("doc",package="affy") system.file("doc",package="affyPLM") system.file("doc",package="gcrma") 7. Glossary Term Definition AffyID An identifier for a probe-pair set. The largest company which manufactures (single-channel) high-density Affymetrix oligonucleotide microarray chips. Chip Description File. Describes which probes go in which probe sets CDF file and the location of probe-pair sets (genes, gene fragments, ESTs). See http://www.bioconductor.org/metaData.html CEL file Cell intensity file, including probe level PM and MM values. Cells grown in tissue culture, representing generations of a primary Cell line culture. DAT file Image file, approximately 10^7 pixels, approximately 50 MB. The type of RNA in a biological sample as described by the DNA Genotype sequence, e.g. using Single Nucleotide Polymorphisms (SNPs) or microsatellite markers. The main microarray analysis software from the Affymetrix company: MAS 5.0 MicroArraySuite-MAS, now version 5. The same as PM but with a single homomericbase change for the middle (13th) base (transversionpurine<-> pyrimidine, G <->C, A <- Mismatch(MM) >T). The purpose of the MM probe design is to measure non-specific binding and background. Perfect A 25-mer complementary to a reference sequence of interest (e.g., part match(PM) of a gene). The type of RNA in a biological sample as described by physical Phenotype characteristics of the biological sample, e.g. time or estrogen presence/absence or observed susceptibility to disease. Probe An oligonucleotideof 25 base-pairs, i.e., a 25-mer. Probe-pair A (PM,MM) pair. A collection of probe-pairs (16 to 20) related to a common gene or Probe-pair set fraction of a gene. RMA Robust Multichip Averaging (Irizarry et al. [6]). A type of RNA under a particular condition (e.g. Estrogen present) Target which is hybridized to a microarray chip.
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About رقص بنات بدون ملابس
رقص بنات بدون ملابس This is not why I think 20th Century Fox was not putting money into this project initially.
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I will say that the one thing that made me mad the most was the CGI. Vegeta, both the prince, his king father and the Saiyan home planet originally named Planet Plant, means Vegetable; Raditz is not `radish`, and Kakkorotto is not `carrot`. Although not encouraged to do not so, main character Claude may not utilize the services of prostitutes, and then subsequently murder and rob them. Not only nothing in this film resembles the original DB, it is a disgrace. In fact i think why sums up the entire movie. While the original `Naruto` cartoon started off with a lot of momentum, there were moments where it tended to lag, especially during the Sasuke Retrieval arc. رقص بنات بدون ملابس Movies like final fantasy have a high budget and talent behind them.

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Boils 11 0
User Ratings
[YEA] I always believed in magic and you proved it today. I have had a big ugly and terribly painful boil on my stomach for a few days. I know this must be because of hair follicle infection as well as fat (yeah yeah, stomach with loads of fat, and hair on it too. hmmm not nice but real). It has been very painful and I am on mission in Nepal of all places. So I googled "boils" this morning to make sure they were not cancerous, and I fall on your website and the turmeric suggestion. Since I do happen to be in Nepal where everyone believes in ayurvedic medicine, I went to the hotel kitchen and asked for turmeric, and drank a full glass of water with a tablespoon of it. Yuck but the waiters were telling me that they drink this with milk to cure their sore throats. I went back to my room and forgot it although I smelled quite bad. 4 hours later, padam, the front of my pants got totally wet with blood and pus. The boil burst open and I burst out laughing. Your remedy WORKS; I thank you so much and will keep this website bookmarked for life.
EC: Read hundreds more testimonials like this one on our boil remedies page!
Replied by Patty
Houston, Tx
05/17/2015I must say that several years ago I had multiple boils, coming and going frequently. The worst was where I had previously had a bartholins gland excised and it kept swelling and subsiding and then swelling back...I measured my days by that gland and when they swell, they sometimes get huge (you ladies Know! ). I read about turmeric then and started taking it...I would take about 1 tsp at a time with water (neat) and could immediately see the swelling go down...I would later take antibiotics for something (I don't remember what) as drs are so apt to prescribe them and it finally went away only to reappear when I recently became infected again after some intestinal problems, was given antibiotics again and the story goes on.....
Thanks and God Bless to all who write in with their stories!Posted by Aaron (Cape Coral, Florida) on 06/21/2007
[YEA] I tried the TURMERIC remedy for boils about 4 days ago, initially with little hope it would work, but in a state of desperation, since this was my THIRD boil in less than 6 weeks, and I had 2 more starting! I went out as soon as I finished reading all of the testimonials on your site, and bought a bottle of Turmeric capsules from my local GNC. That night I took three 500mg caps with dinner, and another 4 capsules before going to bed. (If a teaspoon is good, a tablespoon is better!) The next morning the boil on my stomach, which was a dark purple golf ball radiating excruciating pain the night before, was now a light purple golf ball that was starting to drain, and the pain had gone down by 80 to 90%!
In addition, one of the new boils that was just starting, (a tiny painful pimple,) started to heal, and the other one, slightly larger, while it didn't go away, it stopped growing, and with 72 hours it too drained (really like a normal pimple, only thicker discharge and more painful.)
It's now been about 4 days, and while the large boil is still draining (the core came out yesterday) and is still very tender, it is healing and no other boils are starting.
BUT! The big BONUS is this: The arthritis in my shoulder that I've been suffering with for the last year, is gone, and even more exciting, I have been dealing with Heal Spurs (Plantar Fasciitis) for about 2 years, and have been suffering TREMENDOUS pain in my foot, every day, all day.
Within 24 hours of taking the Turmeric, my feet have COMPLETELY stopped hurting!!!I plan to continue taking at least one capsule a day indefinitely as a preventative for recurring boils, and as an apparent remedy for my Heal Spurs!!! The real miracle here is that I don't even believe in natural remedies! Thanks so much for the great advice!!!
EC: Read much more about turmeric and boils here.Replied by Suemccartin
St. Petersburg, Fl, Usa
10/27/2010My friend shrimps in the gulf around Florida, both himself and many others on the boat keep developing huge boils on several parts of their bodies (forearms and legs mostly). They are convinced it's from the "fish" they handle. I've seen info online (very little) about sea water boils aka saltwater boils. Supposedly caused by the enclosed arms of the rubber coats and the large amounts of fish goo on the rubbers that come in contact with the skin at some point. In the case of shrimpers I also saw something that says they are caused from handling the sludge from the bottom that comes up in the nets with the catch. (A shrimper manually digs through all the seaweed and thus also comes into contact with the sludge out of the nets. )
I'm glad I found this, going to try the turmeric for him... He's been getting antibiotics for them but I'm a huge believer in staying natural and avoiding western medicine if you can, especially in the case of antibiotics which tend to have diminishing effect as the problem critters get immune to it. He believes same, he's into a lot of Chinese medicine but didn't know of anything for boils right off. Just an FYI: a historical fact to file away. Turmeric was used as a yellow die in the middle ages in Europe and probably other parts of the world as well. The spice came over the trading routes (I don't think it was ever cultivated anywhere in Europe). Due to the imported nature of turmeric it was as expensive if not more expensive, than the tyrian shelfish dyes (red, yellow, purple depending upon mordanting and if it was an exhaust dye), from the vicinity of Greece. So that... Ladies & gents, is why your skin goes yellow when you use it. I've had bad skin most of my life and allergies, especially sinus infections around weather change (summer to winter). I was using nettle for the sinuses but since someone figured out it's great for urinary tract issues the price of the tincture has gone from 3 bucks a bottle to 16 bucks a bottle in the US. I'm going to try out the turmeric myself. I can get a pound of powder on ebay for about 6 bucks plus shipping (sounds like a bargain but I'll check the local health food store first). Great site, glad I found it.Posted by Danny (Dallas, TX) on 11/14/2006
[YEA] Turmeric is undoubtedly one of the aces in ayurvedic medicine. I've seen my grandmother & then mother using turmeric for variety of skin problems & wounds, trust me it does work immaterial of what this modern day medicine claims. For those who find ingesting turmeric really difficult can boil a spoonful of turmeric in a glass of milk (sugar to taste) and drink it. It tastes great, try it!
Bunions 1 0
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YEA (1) 100% Posted by Pamela (Charlotte, North Carolina) on 08/29/2008
[YEA] Turmeric cure for bunion pain. Rub dried turmeric spice directly on the bunion for relief. You can also take turmeric pills internally to reduce inflammation but I have not tried that yet. It is a bit messy to rub it on so I do it over the bathroom sink and use a plastic glove so that my hand does not turn yellow. I need to reapply every few days to keep the pain away. It is an easy remedy. You can buy Turmeric cheaply in bulk at the health food stores or in the spice aisle of the grocery store.
Buying Turmeric Capsules - Warning! 0 0Posted by Amandav (Mastic Beach, Ny Usa) on 09/15/2011
Any additives that you find in encapsulated herbals is inevitably going to be a "flow agent", or "packing agent". The flow agents allow the herb to travel through a hopper and into the capsules during the manufacturing process. It also helps the machine in that the parts do not get clogged up as much. The packing agents are for powders that are too slick - where they just fall all over and cannot be controlled. By adding rice or maltodextrin, the powder gets stickier and will pack into the capsules much more readily.
All manufacturers/encapsulators must follow strict FDA guidelines. Any additive must be at a very low percentage - so much so that a person's body will not exhibit side effects. These ingredients are listed as "inactive" so that persons with known allergies can avoid them.
I know, because I worked for NBTY (Nature's Bounty and Vitamin World) for many years.
Cancer 0 0Posted by Rob (Manhattan, New York) on 10/28/2009
the mainstream (BBC) is slowly catching up to what many here already know.. An extract found in the bright yellow curry spice turmeric can kill off cancer cells, scientists have shown....excerpt from following article. http://news.bbc.co.uk/2/hi/health/8328377.stm
Candida 1 0
User Ratings
YEA (1) 100% Posted by Eric (Chicago, Il, Usa ) on 05/29/2011
[YEA] Turmeric is very amazing. I have been using it as an antifungal and antibacterial for awhile now, due to my overgrowth of candida and overgrowth of bacteria. I am a male, 27 years old, so it is common in males as well.
In the morning, followed by a warm glass of lemon or lime water, warm a glass small glass of coconut milk, with out sugar, and add a teaspoon of organic coconut oil (virgin). Mix well. Grind up organic peppercorns, black, to a fine powder ( I use a mortar to sqeeze the oils better). Mix in a teaspoon of this pepper to the milk. Add one teaspoon of organic turmeric. Milk VERY well. Add a half teaspoon of organic clove power. Drink fast, and stir while drinking to get all of the pepper down.
Drink this TWICE daily. Before breakfast, and after dinner.Replied by Dustin
10/20/2014So is your Candida gone from using the turmeric?
Chronic Conditions 0 0
User Ratings
SIDE EFFECT (1) 100% Posted by Moonie64 (Liverpool, UK) on 10/20/2014
[SIDE EFFECTS] Turmeric for Chronic Condition:
Hi I have on going health conditions for 14 years mostly chronic fatigue. Pain which seems to have spread from lower right hand bowel area burning into lower back. Now in my liver and scan has suggested that their are noncancerous tumors, though I don't think they are tumors as they are painful wondering if they are abscess, may by some kind of infection that has spread. I don't know though I am wondering if it may be some kind of autoimmune like lupus because I now have burning in hands and knees.
Anyway the turmeric seemed like it would be good as many of the symptoms I have seem to be relieved by it. However I took it for a week and my symptoms seem to have got worse to the point that I have now stopped it. In the first few days I developed a cough and it hurt the painful bit in my liver when I coughed. I don't know if I should try it again but just take a really small amount.
Any advise would be welcomed. Moonie64Replied by Om
Hope Bc Canada
10/20/2014Moonie64 --- I have tried turmeric in whey powder and water for a liver complaint for a month. It may have had a good effect elsewhere but I noticed no improvement.
I am always taking Milk Thistle as a tincture and it works very well. It can be taken several times a day. For the abscess type of complaint try ESSIAC tea from Essiac West online. It really addresses these things. I am taking it at the present time.
Namaste, OmReplied by Debbie
Price, UK
11/30/2014Hi Moonie64.
You don't say how you are taking the Turmeric? From what I've read, you need to add some black pepper and take with a fat. such as virgin coconut oil. (Which also has many health benefits, as well). Your reaction, could be your body getting rid of toxins? It sounds like you could have Fibromyalgia. so, maybe do some research on that? There are many symptoms. (I have it). Hope that may help you. x
Circulation 1 0
User Ratings
YEA (1) 100% Posted by Connie (Manitowoc, Wisconsin) on 08/12/2009
[YEA] Turmeric for Leg Circulation
Turmeric and Black Pepper seems to make my legs feel warm and relaxed. I used to drink a lot of coffee and started getting leg cramps. Aspirin helped, but who wants to ingest aspirin all the time. I quit the coffee but my legs usually feel cold and tight. One day I made a curry type sauce for some rice and afterward noticed my legs felt much better. Here's what you do:
- Put 2 or 3 tablespoons extra virgin olive oil in a medium size kettle on low/medium heat (not hot - which could encourage the formation of cancerous substances in the oil/starch mix)
- Add 1 heaping tablespoon of peanut butter (get the kind with no mystery ingredients, just peanuts and salt..... Or use raw cashew butter.)
- Add 1/2 teaspoon turmeric (non irradiated if you can find it)
- Add 1/2 teaspoon crushed black pepper
- Add 1/2 teaspoon curry powder (optional)
- Add 1/2 teaspoon garlic powder (or fresh crushed garlic)
- Add 1/8 to 1/4 teaspoon sea salt
- Mix well and let sit on the warm (not hot) burner for 5 minutes or so
- Add precooked cubed chicken and/or precooked brown rice
- Serve warm (that's right, not hot.)
Cold and Flu 7 0
User Ratings
YEA (7) 100% Posted by Lynda (Brisbane, Australia) on 03/08/2010
[YEA] Hi I'm a 61 year old nurse. I have just discovered the magic of Turmeric whilst in India. Use it as soon as cold symptoms arise you can quickly nip a cold.
For the onset of a sore throat, take 1/4 tsnp of organic Turmeric (no fillers) and swallow. Do not eat or drink for 20 min, repeat up to 3 x day until eased. Should only need to do it once or twice.
For a clear runny nose take 1/2 tspn in a glass of warm water 1/2 hour before meals 2x day for 2 days. It will dry the nose As a general tonic use as a condiment in cooking.Posted by Mary (Sydney, Australia) on 02/21/2008
[YEA] Thank you for this fantastic website. I have had the 'common cold' now for over two weeks and taking everything that the Dr ordered, I still couldn't get better. After taking 1/2 teaspoon turmeric powder, 1/2 teaspoon ginger powder, 1/2 lemon and 1 tablespoon maple syrup, I'm well on my way to recovery. Slept all night for the first time last night and feel great today. Thank you once again for giving us the information on this wonderful herb.Posted by Ellen D. on 01/10/2008
[YEA] Turmeric: An Indian friend of mine gave me a recipe for sore throat, colds, flu, sinusitis: Take about a teaspoonful of turmeric powder, a teaspoon full of grated fresh ginger (or equivalent of dried ginger powder), a pinch of ground black pepper, honey or sugar to taste, and put it into about half a cup of water and bring to a boil. Then add about half a cup of milk, heat to just below boiling point, and drink the mixture slowly, while hot. I also supplement this treatment by inhaling steam and keeping a hot water bottle on my head, throat or chest. I used to have colds that lasted two weeks; now I can get over them within three days. - EllenReplied by Terry
Dayton, Ohio
01/05/2010How often should you drink the turmeric with the ginger, pepper, honey. I like home remedies but don't know how often to drink it.Replied by Anndee
Mumbai, India
06/19/2012You cannot boil anything after adding honey.. boil the whole thing without honey, and add honey only when you are about to drink it.Posted by Shireen (Khartoum, Sudan) on 12/13/2007
[YEA] I am a true believer that every illness has a cure in nature without being tampered with, but I have never heard of turmeric to cure coughs and sinuses.Since I found your website by sheer coincidence, while searching for a natural remedy for my wheezing cough and river-running nose, I thought I'd give turmeric a try( 1 tsp turmeric, 1 tsp honey with 1 cup of warm milk)VIOLA! I could breathe again. Thank You So Much EC, you're a life saver.Replied by Allison
Los Angeles, California
03/14/2009actually, I am wondering if i could use this remedy with tumeric for children as well? for allergies and colds, etc? thanks!
EC: Feedback about Turmeric for children here: http://www.earthclinic.com/cures/children_and_infants.htmlReplied by Joyce
Joelton, Tn.
03/15/2009For Allison from Los Angeles, Ca.
If you cook your foods using turmeric, your children are going to get some of it, therefore giving it to them should not create a problem. Remember to reduce the amount given depending on their weight. The usual dosage on most supplements are figured for a l50 lb. male, so if your child weighs 75 lbs. you would give 1/2 of the adult dose. A 25 lb child would get 1/6th of the adult amount, etc.Replied by Allison
Los Angeles, California
03/16/2009Dear Joyce,
thank you so much. this is the most fabulous website that people are out there helping each other. is there a brand of tumeric capsules that are safe and that you recommend? also, any advice on recipes using tumeric?
thank you so much!
EC: Please read our information on buying turmeric starting at the top of this section: http://www.earthclinic.com/cures/boils.html#WARNING
A few turmeric recipes are here: http://www.earthclinic.com/cures/boils.html#TURMERICRECIPESPosted by Susan (Yuma, AZ) on 11/15/2007
[YEA] I started taking turmeric, 1/4 teaspoon once a day in about 1/4 cup of water after my mother told me it quited her cough. I have a cronic cougn especially when my body temperature changes. It is amazing my cough has stopped. However, I have terrible knee pain and sciatic pain but am not sure if I am feeling much relief. I will continue and see what happens.Posted by Dan (Cary, North Carolina) on 10/25/2007
[YEA]Replied by Mark
Las Vegas, Nv
06/20/2010Glad to hear it's working for you. But do not use a microwave to warm your milk especially with the herbs in it. Microwaving foods changed the molecular structure and reduced the nutritional value. Microwaves are just garbage, there is nothing they are good for because of this.


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Little Miss Twin Stars
Pink & Mint Green Flower Dangle Hoop Earring
$ 29 Gilt
$ 88
Regale her with all things enchanted.
Life-of-the-party pieces with plenty of whimsical frills.
The ultimate holiday treats: stuffed rabbits, classic storybooks, and more.
Bright heart earrings, flower charms, and more whimsical accessories she'll love.


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And also the Secretary General of the United Nations has also invited me to the secretariat of the U.N. in New York.
But as hard as she tried, she couldn't help but make her pastel cardigan titillating in secretariat.
The field is so weak it would make a lame old plowhorse look like secretariat.
"office of secretary," 1811, from French secrétariat, from Medieval Latin secretariatus, from secretarius (see secretary). Meaning "division of the Central Committeee of the USSR" is from 1926, from Russian sekretariat.


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Starting Over 1979 R
Amazon Instant Video
|Romance, Comedy
|Alan J. Pakula
|Burt Reynolds, Jill Clayburgh
|Supporting actors
|Candice Bergen, Charles Durning, Frances Sternhagen, Austin Pendleton, Mary Kay Place, MacIntyre Dixon, Jay O. Sanders, Charles Kimbrough, Richard Whiting, Alfie Wise, Wallace Shawn, Sturgis Warner, Mary Catherine Wright, Daniel Stern, George Hirsch, Ian Martin, Aerin Asher, Ben Pesner
|MPAA rating
|R (Restricted)
|Captions and subtitles
|English Details
|Rental rights
|48 hour viewing period. Details
|Purchase rights
|Stream instantly and download to 2 locations Details
|Amazon Instant Video (streaming online video and digital download)
loved it years ago and looked forward to seeing it again. We've come a far piece from Valium.Published 1 month ago by Marian E. Paul
Very funny, Burt's best performance, Jill and Candice both nominated for Oscars, excellent supporting cast!Published 2 months ago by B. Sapien
It made me laugh. He was a man that wanted a serious relationship, and could not make up his mind who was going to fill the bill.Published 3 months ago by Marie A. Cerezo
Released in 1979, "Starting Over" is a romantic dramedy about a recently divorced man, Phil Potter (Burt Reynolds), who tries to get back into dating and finds a new... Read morePublished 3 months ago by Wuchak
i LOVE this cast; miss the late Jill
clayburgh, so adorable and fiesty in her insecurity........... Read more
I had seen this movie when it first was released...it was just a funny , "real people" kind of movie that is still believable today.....glad to add it to my collection....Published 5 months ago by Colleen V.


text:
Awkward Family Photos
March 8th, 2013
There really isn't anything on this planet quite as an embarrassing and awkwardly composed, poorly shot, family photo. Thank god. These things are bad at the best of times, but these ones really take family portraits to another level.
0 Comments / Add Comment
Abum Macho Video Funny Sh#t Pugorama One Humor LiveDump Melted Brain BoredTown Voomed Hot Videos Killer Kool Games Funny Links Cool Dump Humor and Fun Viral Videos Fashionistas Muppetism Celeb Buzzer Celebrity Smacks Happy-Clips Thrill Blender BabesAnatomy Fun Draft Hyper Cool Stuff


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Lentil Soup with Ham
|Cooked ham shank
|2 Pound
|Dried lentils
|1 1⁄2 Cup (24 tbs)
|3 Tablespoon
|Chopped celery
|1⁄2 Cup (8 tbs)
|Chopped leek
|1⁄2 Cup (8 tbs)
|Chopped onion
|1⁄2 Cup (8 tbs)
|Garlic clove
|1 Small
|1 3⁄4 Teaspoon
|Dried thyme leaves
|1⁄4 Teaspoon
|Coarsely ground black pepper
|1⁄4 Teaspoon
|Sliced frankfurters
|1 Cup (16 tbs)
|Dairy sour cream
|1 Tablespoon
|Chopped parsley
|1 Tablespoon
Trim excess fat from ham shank.
In large kettle, combine ham shank and lentils with 5 cups cold water; bring to boiling.
Reduce heat; simmer, covered, 1 hour.
Meanwhile, melt butter in medium skillet.
Add celery, leek, onion, and garlic; saute 5 minutes.
Add sauteed vegetables, salt, thyme, and pepper, along with 2 cups water, to ham shank and lentils.
Simmer, covered, until lentils are tender—about 30 minutes.
Remove ham from soup; cool.
Then cut ham from bone, and dice.
With potato masher, mash vegetables, right in kettle; leave some lentils whole.
Add diced ham to soup, along with frankfurters; simmer, covered, 30 minutes longer.
(For a very thick soup, simmer uncovered.) Serve topped with sour cream and parsley.
Makes 8 cups; 8 servings.


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Strait of Belle Isle
Marine Forecast
Issued 03:00 AM NDT 04 July 2015
Today Tonight and Sunday
Wind variable 10 to 15 knots.
Showers ending this afternoon. Fog patches.
Issued 06:00 AM NDT 04 July 2015
Strait of Belle Isle - eastern half
Today Tonight and Sunday Seas 1 to 2 metres.
Strait of Belle Isle - western half
Today Tonight and Sunday Seas 1 metre or less.
Extended Forecast
Issued 03:00 AM NDT 04 July 2015
Monday Wind northeast 15 to 20 knots.
Tuesday Wind south 10 to 15 knots.
Wednesday Wind south 15 to 20 knots.
Ice Forecast
Issued 10:00 AM EDT 3 July 2015 Today Tonight and Saturday Bergy water.
Stay connected
Weather Conditions
Zoom-in to make a selection
Land Station
Ice Conditions
Ice ForecastsIssued 10:00 AM EDT 3 July 2015 Today Tonight and Saturday
Ice EdgeIce edge estimated from Labrador 5705N 6125W to 5720N 5840W to 5800N
5800W then northward. Sea ice north of the ice edge.
Ice Coverage
Bergy water.
Iceberg BulletinIssued 11:00 AM EDT 3 July 2015
Iceberg LimitIceberg limit at 0000 UTC 3 Jul estimated from Newfoundland near
4650N 5404W to 4600N 5400W to 4145N 5000W to 4145N 4845W to 4645N
4330W to 4900N 4400W to 5530N 4730W to 6000N 5700W.
Western iceberg limit at 0000 UTC 3 Jul estimated from Quebec near
5038N 5925W to Newfoundland near 5000N 5744W.
Iceberg Count26 to 50 icebergs.
No watches or warnings in effect.
Technical Marine SynopsisIssued 3:00 AM NDT 4 July 2015 Today Tonight and Sunday At 3:00 a.m. NDT today low 1000 mb located over southern Funk
Island Bank.
By 10:00 a.m. NDT today departing low located east of Funk Island
At 10:00 a.m. NDT Sunday approaching low located south of Nova
Marine Weather StatementIssued 7:49 PM NDT 3 July 2015 A developing low pressure system south of the Burin Peninsula will
cross the Avalon Peninsula this evening and the Funk Island Bank
early Saturday morning. Near-gale force southwest to west winds are
expected across the Grand Banks as the low passes. Marine interests
are advised to monitor future forecasts in the event that gale
warnings are required.
Atlantic - Newfoundland Area
- Anticosti
- Banquereau - northern half
- Banquereau - southern half
- Belle Isle Bank
- Bras d'Or Lakes
- Cabot Strait
- Chaleur - Miscou
- Eastern Shore
- East Coast - Cape St. Francis and south
- East Coast - north of Cape St. Francis
- Fourchu
- Funk Island Bank - northern half
- Funk Island Bank - southern half
- Gulf - Magdalen
- Gulf - Port au Port
- Lake Melville
- Laurentian Fan - northwestern half
- Laurentian Fan - southeastern half
- Mid Labrador Coast
- Northeast Coast
- Northeast Gulf
- Northern Grand Banks
- Northumberland Strait
- Sable
- Southeastern Grand Banks
- Southwestern Grand Banks
- Southwest Coast
- South Coast
- South Labrador Coast
- South Labrador Sea - western half
- Strait of Belle Isle
Another Region
- Arctic - Eastern Arctic
- Arctic - Western Arctic
- Atlantic - Labrador
- Atlantic - Maritimes
- Atlantic - Newfoundland
- Great Lakes - Lake Erie and Lake Ontario
- Great Lakes - Lake Huron
- Great Lakes - Lake Superior
What we are doing
Weather Forecasts
Weather Alerts
Weather Resources
- Date modified:


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YIELD: Serves 4
Combine first 6 ingredients in medium bowl. Season to taste with salt and pepper. (Can be prepared 1 day ahead. Cover and refrigerate. Bring mixture to room temperature before using.)
Prepare barbecue (medium-high heat). Brush fish generously with oil. Season with salt and pepper. Grill until just cooked through, about 3 minutes per side. Transfer to plates. Stir parsley into eggplant mixture and arrange atop fish. Drizzle lightly with oil and garnish with lemon wedges.


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We had a reservation here because the price was right. It was an overnight stay and reviews were decent. We arrived at 10:45 pm and were told if you don't call by 6 pm they release the room. The confirmation says guaranteed by credit card for late arrivals. Luckily the clerk hadn't released it yet. All other hotels in area were booked. Room stunk of cigarette smoke despite signs everywhere stating 100% smoke free. Everything very dated.
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Travelocity, Red Roof Inn, Priceline, Orbitz, Odigeo, Cheap Tickets and Hotels.com so you can book your Red Roof Inn St. Louis St. Charles reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Red Roof Inn Saint Charles
- Saint Charles Red Roof Inn


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Helen Day Art Center presents our 24th annual outdoor sculpture exhibition. Image: Rodrigo Nava.
This exhibition will feature artwork from current MFA candidates enrolled in any MFA program in New England, New York, and Quebec. Image - Come, run in me by Christy Chow
Take advantage of Stowe's pristine beauty and natural history in these one-of-a kind, personalized art workshops for youth and adults.
2014 was filled with educational adventures... Check out our offerings for 2015!
© 2015 Helen Day Art Center - 90 Pond Street, PO Box 411, Stowe Vermont 05672 - (802) 253 8358


text:
There's no hibernating for Henry Vilas Zoo; the zoo is open 365 days a year and even in the middle of a Wisconsin winter, there are many reasons to take a stroll through the exhibits.
WATCH Leah Linscheid's report on winter-loving zoo critters.
It was a rookie K-9 officer that helped police track down an escaped mental health patient in north Madison Wednesday night, police said Friday.
Wednesday at about 10 p.m., Madison officers were called to help Mendota Mental Health Institute staff find a patient who ran off while being escorted to a building on the MMHI campus.
Madison police spokesman Joel DeSpain said K-9 Frees and his partner Officer Nicholas Eull were part of the responding teams at the north Madison facility.
DeSpain said Eull used a sterile gauze pad to pick up the escapee's scent from the back of the vehicle in which the patient was transferred.
West side residents have a new place to play with their pups.
Walnut Grove Park officially opened Monday afternoon with an opening ball toss ceremony. The park at 202 N. Westfield Road is the eighth Dane County dog park.
Madison Parks Superintendent Eric Knepp said buying a pass for the park extends throughout the county.
Starting Monday, Walnut Grove Park, 202 N. Westfield Road, joins seven other parks in the city of Madison as locations for a fenced dog exercise area.
Everyone and their dogs are invited to join Mayor Paul Soglin, Madison Parks Superintendent Eric Knepp and the west side neighbors and dog owners for a special unveiling.
There will be an official 'ball toss' opening at 1:30 p.m. on Monday at the park.
"Madison Parks in committed to providing safe places for dogs and their owners to exercise and enjoy the outdoors. The city of Madison is proud to be ranked number 6 in the nation for off-leash dog parks by the Trust for Public Lands," said Knepp.
Click here to find out the dog park rules.
The cost of the Annual Permit is $30 and the daily permit is $5.
Madison?s Henry Vilas Zoo announced Wednesday that two new residents will be moving in as soon as their home in the zoo?s new Arctic Passage Exhibit is finished.
Zoo Director Ronda Schwetz said the new residents are two grizzly bears who are currently at the Bismark?s Dakota Zoo, in North Dakota.
The bears were born in the wild, and their mother and grandmother were nuisance bears, which mean they were too comfortable being around people. They broke into campsites, and the grandmother had to be relocated 11 times to keep her away from people.
Then the grandmother broke into and raided a pig farm and became too dangerous. Officials euthanized the mother and grandmother, leaving four cubs behind.
Madison will be helping the zoo in North Dakota out by taking two of the cubs. The bears don?t have names yet, but zoo officials hope the community will help them out with that.
The newest member of the Madison Police Department?s Mounted Unit will be announced Monday at a Community Corral, according to a release.
Torres is an 8-year-old Friesian Gelding that has spent the last two months in field training with the unit, and has now earned the right to start his solo career, officials said. Torres joins the unit thanks to a private donor working in conjunction with MPD?s nonprofit organization.
In March, Jack, a veteran horse member of the unit, passed away following a short illness, according to the release. But Torres has filled the void and is ready to carry on in Jack?s footsteps.
Torres will be introduced to the public at the Community Corral from 5-7 p.m. at Vilas Park. The unit?s team members will also be available to share information and answer questions about the horses and the responsibilities of being a mounted police officer.
The city's equestrian police team is scheduled to make appearances at three parks this month to meet with the community.
The Madison Police Department said its mounted patrol unit will hold "Community Corral" stops on the south, west and northeast sides of the city.
The Community Corral is an informal meet-and-greet event, organizers said.
Police said the park events are "a great way to 'corral' up area neighbors to say hello to the largest four-legged members of the police department."
The mounted patrol is scheduled to stop by from 4-5 p.m. at:
Flyways Waterfowl Museum
Barnes & Noble Booksellers East
WISC-TV/Channel3000.com, 7025 Raymond Road, Madison, WI 53719
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Copyright 2015


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I made this using an embellished piece I found at a shop. I then place it on black felt for backing and hand stitched pleats onto the ribbon straps and then added another layer of black felt backing for extra security!
The sun was shining on the sea, Shining with all his might: He did his very best to make The billows smooth and bright--
Pressing neckties to make brooches and other trashion fashions


text:
|Reviews for Bananas and apples
| I believe in nargles too chapter 1 . 6/26
I think i understand but can you clarify what is happening please.
| Ace chapter 1 . 2/22/2014
This is my favorite fanfiction. I can't believe you wrote it in only 10 minutes. I must have read it 15 times in the last 6 years or so. I don't know what it is about it. Maybe it's just the tone. Just, how you are so skilled at making Harry sound... simple? Damaged? And his obsession with red, and how Snape leaves spaces at the table and half smiles at him. It's just great.
Anyways, I realize you posted this nearly 10 years ago, so you may never read this review. I just wanted you to know that I appreciate this.
| BeLlIxiEs chapter 1 . 9/30/2013
That was so sad...
loved it though...
| Boompow chapter 1 . 6/1/2013
Please write a sequel this has so much potential
| Guest chapter 1 . 5/11/2013
he cut up ron...
| bodo1971 chapter 1 . 11/7/2012
A lot room for imagination.
| snarryself chapter 1 . 6/30/2012
Ok so harry killed Ron and a lot of professor. But im still a little confuse. But i love the feeling the story has. Harry can't tell what is wrong but the actions of those around him say so much.
| Aisha Salke chapter 1 . 5/10/2012
Though I can't honestly say that I know what exactly is going on, I can say that I did enjoy reading this. I hope that one day you will revisit this storyline and expand on what you have; I'd love to see more and maybe get a little more back-story as to what happened.
As near as I can tell, and I freely admit this is only my interpretation of it, it seems that after defeating Voldemort the Horcrux that was in Harry did some kind of damage to his mental state. I don't know if the opinion of other reviewers is correct when they say they think Harry killed Ron. I can see him being dead but that could have happened during the battle, the same with the professors who are missing; I can see people keeping watch over Harry for all he sacrificed for them.
The hints you gave for the Harry/Severus interactions could actually be romantic or 'brotherly' so that is another thing it would be nice for you to fully explain so that I can fully understand them. I assume the routine of questions is to see if Harry is recovering who he once was, memories and all.
As far as a deeper understanding of their interactions, as I said I can actually see it from both views. For brotherly I can see Severus keeping his promise/vow by watching over the savior once more. I can also see the reason for Harry staying with Severus being that they were in a relationship and while he can't do anything to/with Harry at the moment he also can't abandon him.
I can also believe that something might have snapped in Harry and he did something to others, mostly because of the image Harry project with his obsession with cutting; though the attraction to the color red could again be taken one of two ways. In one way it can be read as a desire of/for blood, but it could also be an allusion to Ron as he was often associated by his red hair color. So I can see Harry associating red with him and, because he was his friend, finding comfort in that color.
Though a bit too vague for me to gain conclusive answers about, I do believe that this was well-written. As I said before I do hope that one day you'll come back to this and perhaps provide some answers to those questions.
| Autumn Alchemist chapter 1 . 1/20/2012
I loved it. It sounded like a River Tam rambling, and I believe I was able to decode it perfectly. I loved the way you wrote this. It made perfect sense. I would certainly be interested in reading a sequel.
| sneaky lunitic spy chapter 1 . 11/20/2011
this makes no sense but perfect sense i love it
| Blueberre chapter 1 . 10/21/2011
Loved it! Harry seems mental but you're not completely sure...and theres this tangible sadness throughout it all. awesome!
| Phobiakat chapter 1 . 8/2/2011
OMG! This is completely insane, and I love it! Harry's mental! This was so creppy. You're a really good writer. It takes a lot for me to say that a piece of writing is scary/creepy!
| anon chapter 1 . 7/31/2011
Very nicely done!
| love-severus-10 chapter 1 . 4/4/2011
I didn't understand this story to well so if you could please explain it in maybe an authors note or something that would be great.
| Hermioneloverox chapter 1 . 9/29/2010
Random much? Please, dom\n't update:(


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Looks Great, let us know how it works out!!
"I love not man the less, but Nature more."
Looks great. I think we appreciate things more when done ourselves.
That's very nice work! Looks nice and warm.
But Jesus often withdrew to lonely places and prayed. (Luke 5:16 NIV)
He said to them, But now let the one who has a moneybag take it, and likewise a knapsack. And let the one who has no sword sell his cloak and buy one." (Luke 22:36 ESV)
While people are saying, There is peace and security, then sudden destruction will come upon them as labor pains come upon a pregnant woman, and they will not escape. (1 Thessalonians 5:3 ESV)
Got it all finished up. Total length ended up 73x48. I have a drawcord bottom and snaps for the foot box. Has about 2.5 - 3" of loft. I haven't had a chance to try it yet, but I do have a question. I can see where all my down is since the gray is so light and it looks like there are some thinner spots and thicker. Should I be worried about that? Here's the pics
Looks great... Only time will tell about the thinner and thicker looking spots...
Live, Laugh, Love, if that doesn't work. Load, Aim and Fire, repeat as necessary...
Buy, Try, Learn, Repeat
Nice looking quilt! Great work!
That looks fantastic! Well done. I don't think the thin/thick spots should be much of a concern unless there are large gaps with no down at all.
Put it in the dryer, with NO HEAT, along with a few clean tennis balls. That should even out the down and fluff it up.
"Life is a Project!"


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There is no room in the world for these acts. This man should be put to life if he is guilty.
If selected for publication, it will appear as soon as possible on Haaretz.com.
A prosecutor in the U.S.state of New Jersey says a 19-year-old unemployed man charged in the firebombings of two synagogues is an anti-Semite who intended to cause harm.
Bergen County Prosecutor John Molinelli said Tuesday that investigators believe Anthony Graziano of Lodi knew there were people inside when he threw Molotov cocktails into a Rutherford synagogue building that also houses the rabbi's family.
Molinelli says Graziano rode a bike to the synagogue, and one of the first firebombs he threw into the building landed in the rabbi's second-floor bedroom while the family was asleep.
Graziano faces nine counts of attempted murder. Molinelli says the charges carry a minimum 30-year sentence because of the number of people in the building. No one was seriously injured.
Graziano is also charged in an earlier firebombing in Paramus.


text:
Narrow your search
The highlight of Panasonic's camcorder announcements are a couple of feature-packed 4K/UHD models.
The Panasonic AS530 series LCD ain't no plasma, but it offers attractive design and decent image quality for a budget price.
A new prosumer run-and-gun-style camcorder has tons of entry-level pro features -- it's just missing the three sensors.
CNET did not review the EM60 series of LED-based LCD TVs, but we did review the E60 series. See how the two series differ in our Quick Take.
The Panasonic S64 series of plasma TVs, limited to two screen sizes and select retailers, represents as good as value as the ST60 and S60 models.
Pricing not available
The Panasonic TC-PS60 plasma TV's low price, high-end picture quality, and bare-bones Smarts make it one of the best values we've ever seen.
The midlevel price and outstanding quality of the Panasonic TC-PST60 series make it our strongest TV recommendation ever.
Some first impressions of the company's new compact, least expensive interchangeable-lens camera.
The entry-level Panasonic X5's color problems make it the worst choice among the year's cheap plasmas.
A low price, excellent picture quality, and bare-bones features make the Panasonic TC-PU50 series a superb entry-level plasma TV value.


text:
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text:
Strange: Most Gun Violence Occurs In Liberal Hotbeds
Starting off with a letter to the editor of the Washington Post, providing an uncomfortable truth
The fact that President Obama's second inauguration was held on Martin Luther King Jr. Day is ripe with symbolism. But our nation's first black president has done too little to champion the social equality at the core of King's message. We remain a wealthy nation marred by poverty and violence, which disproportionately affect the black community. Mr. Obama's recent gun proposals, hailed by many as a bold move, once again skirt the real problems we face. The president was galvanized into action by a massacre in a white, middle-class, suburban community. In reality, more than half of gun homicide victims in 2010 were black, while blacks compose just 13 percent of our population. Four U.S. cities rank among the top 50 worldwide in murder rates.
And just how bad are the big cities, which tend to be liberal? Here's the Atlantic, with a spiffy map that compares the rate of gun murders to foreign countries and finds
- If it were a country, New Orleans (with a rate 62.1 gun murders per 100,000 people) would rank second in the world.
- Detroit's gun homicide rate (35.9) is just a bit less than El Salvador (39.9).
- Baltimore's rate (29.7) is not too far off that of Guatemala (34.8).
- Gun murder in Newark (25.4) and Miami (23.7) is comparable to Colombia (27.1).
- Washington D.C. (19) has a higher rate of gun homicide than Brazil (18.1).
- Atlanta's rate (17.2) is about the same as South Africa (17).
- Cleveland (17.4) has a higher rate than the Dominican Republic (16.3).
- Gun murder in Buffalo (16.5) is similar to Panama (16.2).
- Houston's rate (12.9) is slightly higher than Ecuador's (12.7).
- Gun homicide in Chicago (11.6) is similar to Guyana (11.5).
- Phoenix's rate (10.6) is slightly higher than Mexico (10).
- Los Angeles (9.2) is comparable to the Philippines (8.9).
- Boston rate (6.2) is higher than Nicaragua (5.9).
- New York, where gun murders have declined to just four per 100,000, is still higher than Argentina (3).
- Even the cities with the lowest homicide rates by American standards, like San Jose and Austin, compare to Albania and Cambodia respectively.
Strange. All those places tend to be hives of Progressive ideals. Even big cities like Houston and Phoenix tend to lean left. Perhaps we should simply restrict those who vote Democrat from owning guns. Oh, wait, in most of those areas they are restricted, along with everyone else. Except criminals.
Crossed at Pirate's Cove. Follow me on Twitter @WilliamTeach.
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"Trojerucica" (on serbian) - "Triherusa"(on greek) - "Threehanded"(on english) stands above chair of Abbot, and the Abbot of the monastery(Greece order the Serbs that they must have an man Abbot) sits to her's right side.
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text: Education Charter School Add-On Dooms Kentucky Education Reform Bills An attempt to piggyback charter school legislation on another bill has likely killed two plans for education reform in Kentucky. The state Senate Education committee Thursday added language legalizing charter schools to a charter alternative plan sponsored by Representative Carl Rollins, who chairs the House Education Committee. Charter supporters hoped Rollins would allow the amendment in order to see his alternative become law, but it's unlikely the plan will work. Bill Would Give Local School Boards in Kentucky Power to Raise Dropout Age By Kevin Willis • Mar 27, 2012 Kentucky lawmakers are trying again to raise the state's dropout age. Currently, students can drop out of school at 16 years old with parents' permission. But lawmakers and Governor Steve Beshear have pushed to raise the dropout age to 18, regardless of parental consent. Regional Meetings to be Held to Discuss Teacher Quality By Dan Modlin • Mar 27, 2012 Prichard Committee for Academic Excellence Citizens in ten communities across Kentucky will be participating Tuesday evening in discussion groups and viewing a ninety minute movie titled, "American Teacher." The activity is sponsored by a number of advocacy groups, including the Kentucky Association for School Superintendents, the Kentucky Chamber of Commerce, the Kentucky School Boards Association, and the Prichard Committee for Academic Excellence. Organizers say they hope to spur discussion about the importance of placing and retaining excellent teachers in the classroom. Appalachian Scholarship Compromise in Trouble A proposal to create a scholarship fund for far eastern Kentucky college students could be in jeopardy. The Appalachian scholarship fund was intended as a compromise, after a measure to move the University of Pikeville into the state system couldn't garner enough support. In the House's version of the budget, lawmakers funded the scholarships with coal severance tax money. "Honoring Our History Tour" to Visit Louisville By Dan Modlin • Mar 24, 2012 A free exhibit called "Honoring our History Tour" will be on display at Slugger Field in Louisville Monday, and the Kentucky Department of Veterans Affairs says donations will be accepted. According to Kentucky Department of Veterans Affairs Commissioner Ken Lucas, half of all donations collected at the site will go to the veterans cemetary in Radcliff. House Passes Bill to Allow Older Refugees to Stay in School By Associated Press & Dan Modlin • Mar 19, 2012 LRC Refugees would be allowed to remain in Kentucky high schools past their 21st birthday under a measure that has cleared the Kentucky House of Representatives. House Bill 183 is sponsored by Bowling Green Democrat Jody Richards, who says the proposal is intended to help refugees who have come to the United States to escape persecution in other countries. Author of Best Selling Book on Climate Change to Speak at WKU By Dan Modlin • Mar 15, 2012 Dr. Brian Fagan, Professor Emeritus at the University of California, Santa Barbara, will give a "Reach Week" lecture on the WKU campus on March 21st. Fagan is the author of the best selling book, "The Great Warming:Climate Change and the Rise and Fall of Civilizations." He has done extensive research on the ways civilization has adapted to climate change in the past. His lecture in Van Meter Auditorium will be free and open to the public. Dr. Fagan talks with Dan Modlin.......... WKU Historian to Appear on NBC Television Tonight By Dan Modlin • Mar 9, 2012 WKU History Department WKU History Professor John Hardin, who specializes in African American History, will appear tonight on the NBC television network program, "Who Do You Think You Are?" Dr. Hardin helped to research the family history of former Pittsburgh Steeler running back Jerome Bettis, the family story that will be traced in tonight's program. The story has roots in slavery in western Kentucky. Dan Modlin has more....... Compromise Deal on Educational Opportunities LRC Lawmakers have reached a compromise on a proposal to create more educational opportunities in eastern Kentucky. House Speaker Greg Stumbo has been advocating to move the University of Pikeville into the state university system. But that proposal doesn't currently have the support to become reality, which forces supporters to adopt a compromise. WKU Campuses Closing Early Due to Severe Weather Threat By WKU Public Radio News • Mar 2, 2012 Given the potential of unusually severe weather this afternoon, the WKU Main and South Campuses will close at 12:30 p.m. today. The Glasgow campus will close at 1 p.m. Central, and the Elizabethtown/Radcliff/Fort Knox campuses at 1 p.m. Eastern. We are awaiting a possible announcement from the Director of the Owensboro campus. Pages« first ‹ previous … 53 54 55 56 57 58 59 60 61 next › last »


text:
Emotional Reunion Between Man and His Dying Dog May Leave You in Tears
There's nothing like seeing an old friend.
There's nothing like seeing an old friend.
If it was the first time I had this problem, I probably wouldn't be talking about it but, it keeps happening again and again.
When I bring animals into my home, they become my family. About 10 years ago, I kept saying I want a cocker spaniel. I love cocker spaniels, I had one growing up and they are so kind and loving and just beautiful dogs. Then one day I got my cocker spaniel.
This poor dog just wants his stick. He just can't seem to get it off the ground. Watch the video to find out why.
My friend Robyn and I always joke about wanting to own a miniature pet farm. We would raise pygmy goats, miniature pigs, horses, etc. I think it would make an awesome farm!
Mondays are tough enough without having to have a sad moment in the morning. You see I live on a street with a lot of cats. Not stray cats, fat cats. They are everywhere and to me that is OK because that means they have a loving family.
Want to lower your stress levels at the office? Take your dog to work. Research finds employees who do so not only experience less angst during the day, but their co-workers could benefit from Fido's presence too.
If you have or are thinking of having kids, it might be a good idea to also add a pet to the equation. That's because last month a study found that babies who grow up in households with pets are healthier than their pet-less counterparts. And now a survey of children suggests that having a furry friend is one of the keys to academic success.
I have always had dogs. My son has always been around dogs. He rarely got sick as an infant and rarely gets sick now. Now, I know why. It could be our dogs Bailey and Jasper. According to a new study in the medical journal of Pediatrics, dogs can help keep infants healthy.
I will never understand how human beings can be so cruel. How can someone throw an innocent animal out of a car going 70 miles per hour.
In honor of adopt a shelter cat month, I thought I would share my story. My cat adoption story. My almost 3-year old kept talking about a kitty and wanting a kitty and I wanted to make that dream a reality for him.
There's an old adage that says people and their dogs eventually start to look alike. But new research shows the type of dog we choose actually has a lot to with how well they match our own personalities, too.


text:
You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
"This invitation is just beautiful! I used several different fonts, which made the "surprise" part of the invitation stand out. The invitation is thick, the color is rich, the printing is clear and bright. I had the invitation looked at by a design specialist before printing. I was given a choice between my design and one the designer tweaked for me. The designer put the SURPRISE part at the bottom in capital letters. Looks beautiful. My invitations are all address and ready to send. This invite will truly make an impression on the type of party we are having. Thanks so much!"
"After getting the best matching photos, it all came together. Good and timely help from customer service and designer. Product quality and timeliness exceeded our expectation."
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"I loved how easy it was to just put in the information I wanted and not spend hours trying to put this together myself! I was able to easily upload my parents wedding picture and really personalize this invitation. Some of the guests thought it was an ad!"


text:
By Ollie Irish
A mascot named Changy? With a trunk! All day long.
"You're my soldier, right? That's right."
"A man got to have a code."
Dip in to scour the latest Deadline Day titbits...
hahah yes!
its spelled "llello", not "yayo", but still awesome
[…] Who Ate All The Pies […]
The Omar of mascots
[…] Chang The Elephant Is The Most Awesome Football Mascot In The World […]
dave it is spelled llello but over the years it was bastardized into yayo because of the way it's pronounced. u know that already though.
Hahahha this is too good to be true. I love it!
[…] Name: Changy the elephant. As mentioned before on Pies, Changy is fucking awesome. […]


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Worth Reading: 11/21/2014
An examination of Unity's take on the French Revolution, highlights from the growing world of Twine, and much more.
Meet the Clones
Threes is the latest game to fall victim to the increasingly rampant cloning of smaller video games, especially on mobile. We spoke to the people who made these clones, and tried to find out why.
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An Excessive Heat Warning is in effect from 6/25/2015 9:00 AM to 6/27/2015 9:00 PM PDT for Mohave County. Learn more about how to stay safe in extreme heat and stay informed about future heat alerts.
Extreme Weather and Public Health
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- Arizona Extreme Weather Climate and Health Profile Report 2015 - Executive Summary
- Visit the News & Publications page for additional items.


text:
Alan MX - Mixed'icord!
Alan MX does not rob banksWe're very pleased to announce that Alan MX has finished work on his forthcoming debut album, Warpsichord! The record was recently mixed over five frantic days at London's Southern Studios by one Mr Harvey Birrell, whose recent CV includes a certain album named Backlash Cop. Exciting, non?
While we've yet to set a release date for the album, we can reveal several more bits of information! Firstly, that artwork is being handled by Matthew Barnes, who some of you may know from the the beautiful tree-themed sleeve from 'Public Service Broadcast 9'. Secondly, that the first single from the album will be for the track "The Captain America Video", which is going to feature some exclusive b-sides and will arrive shortly before it's parent album. A video is currently in production for the track as well! A rough mix of the track can currently be heard over at Alan's myspace page.
Alan's also started a brand new blog, to talk about some of the influences and the creative thoughts and processes that went into making the record, and where hopefully he'll chart where the next year or so takes him! Go have a read.
Oh, and don't forget that STA also have their own blog, over this way! Check it out now for Andrew's jealousy-inducing rundown of SxSW 2008.
Alan MX Myspace | Alan MX Blog | STA Official Blog
Recent Posts
- USA Nails Announce New Album 'No Pleasure' July 2, 2015
- STA All Dayer #6 July 2, 2015
- Total Guitar Feature Axis Of June 19, 2015
- Blacklisters to Release First Song June 18, 2015
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- We Versus The Shark
- The Young Playthings


text:
Reacting to reactions
Hello, I'm Keith Jones, and I am Head of Communications and Complaints in BBC Audience Services, which doesn't describe very clearly what I, or my team, do. I'm responsible for managing a large chunk of the services we provide for our audiences.
We have felt for some time that we should explain more about what we do, so I plan to use this blog to do that and also explain some of the issues generating reaction from audiences.
One of our most popular services is providing tickets to our radio and TV shows or events, and for the award-winning tours of our studios and buildings. I'd urge you to come and visit: we promise you'll have a really good time visiting or coming to a BBC show.
But there's another important side to our work. It's through my teams that most people send in their comments, appreciations or complaints about BBC programmes, either online at the Contact Us site or by telephone (look up BBC in your phone directory). As a result of all this feedback we know a lot about how people react to our programmes.
The strongest demand is always for more information or help using our services. We provide this mostly online on the Help site and although we can't answer everything, we do our best to find answers and publish them online. And for some of the issues covered in programmes we provide access to further information and sources of advice on our Action Line site.
Every morning one of our services is to collate the reaction we've received and report it to programme makers and managers across the BBC. If you read the press you'd think the BBC only receives complaints but although newspapers are always more interested in complaints, they are a relatively small proportion of all the reactions we receive.
For example, many viewers were recently moved by the quality of our documentary Wounded and contacted us to say so. We've also had appreciations for Life, The Choice, The Choir and Strictly Come Dancing. We did have many complaints about the replacement of Arlene Philips by Alesha Dixon, but we've also had appreciations for Alesha now the series is up and running.
We had lots of reaction to a recent interview with Gordon Brown, and you'll be only too aware of the response to the inclusion of the British National Party in Question Time. We have editorial obligations and standards which we must keep to across all our coverage, so in such cases we try to explain why when we believe criticism is misplaced (a good example can be seen on Ric Bailey's blog or in Mark Thompson's response on this blog).
How do we react to all this reaction? The short answer is that it depends on what it is about. Sometimes we can change things, sometimes we can't. For example when thousands of viewers complained that they were unable to watch the opening ceremony of the Beijing Olympics because it was screened during working hours, we changed our schedules and were able to repeat it. We read every comment (yes, every comment) and make them available to producers and managers in our reports. But we are mindful to listen to what other audience research findings tell us as well as those who contact us.
If we get something wrong we should apologise and say so. But often we are unable to agree with those who complained and try to give our reasoning. So we provide a rigorous complaints service, and we publish regular summaries of the main issues we have considered and which people have raised.
We can't please everyone, and must often balance competing pressures. During Wimbledon this year, for example, many people were pleased that we kept some key matches on BBC One when they overran. But others were extremely unhappy about the disruption which inevitably followed to the rest of the schedule, especially to our news bulletins at 6.30pm. So, obviously, we must take this into account in planning our coverage next year.
The importance for us is to carry on listening to your reaction. We're grateful that our programmes matter so much to so many. We take everyone's reaction seriously and can sometimes act on it, but I hope this helps to explain why the BBC cannot always respond in the many ways different people would like us to.
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text:
Standing Committees
1. Piper Award Committee (Will be updated soon!)
College of Education: Stacey Gaines
College of Ag: David Hewitt
College of Engineering: Francisco Aguiniga
College of Arts & Science: Jose Guerra
College of Business: Ashley Bennington
2. Annual Faculty Lecture Committee (Will be updated soon!)
Dean Ferguson (Chair)
Angel Ball
Roberto Vela Cordova
Anders Greenspan
Tanner Machado
Michael Muzheve
3. Administrator Evaluation Committee (Will be updated soon!)
Amit Verma (Chair)
Maria Ayala-Schueneman
Don Fisher
Nestor Sherman
4. Special Task Committee (Faculty Count)
Yahia Al-Smadi
Maria Ayala-Schueneman
Don Jones
Hueytzen Wu
5. University Strategic Planning Committee
Rajab Challoo
Nestor Sherman
6. Promotions Appeals Committee
Melody Knight
7. Undergraduate Program Review
Kendra Huff
This page was last updated on: May 12, 2015


text:
Can Diet Impact Aging?
From the days of domesticating agriculture our diet has played a huge role in who we are as a species. As technology advanced we were able to do more with food and learn more about what food does to us. Now scientists are asking bold new questions and getting some pretty amazing answers. For example, can diet impact aging?


text:
Robert B. Parker's Fool Me TwiceHardback Jesse Stone Novels
List price $35.99
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- Paperback $9.73
- Publisher: Thorndike Press
- Format: Hardback | 307 pages
- Dimensions: 147mm x 218mm x 28mm | 431g
- Publication date: 5 September 2012
- Publication City/Country: Detroit
- Edition: Large type / large print
- Edition statement: large type edition
Product description
Summer in Paradise, Massachusetts, is usually an idyllic season?--but not this time. A Hollywood movie company has come to town, and brought with it a huge cast, crew, and a troubled star. Marisol Hinton is very beautiful, reasonably talented, and scared out of her wits that her estranged husband's jealousy might take a dangerous turn. When she becomes the subject of a death threat, Jesse and the rest of the Paradise police department go on high alert. And when Jesse witnesses a horrifying collision caused by a distracted teenage driver, the political repercussions of her arrest bring him into conflict with the local selectment, the DA, and some people with very deep pockets. There's murder in the air, and it's Jesse's reputation as an uncompromising defender of the law--and his life--on the line.
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Robert B. Parker was the author of more than fifty books. He died in January 2010.Michael Brandman is the author of the New York Times bestseller "Robert B. Parker's Killing the Blues." He is the award-winning producer of more than thirty motion pictures, and collaborated with Robert B. Parker for years on movie projects, the Spenser TV movies, and the Jesse Stone series of TV movies starring Tom Selleck. Brandman cowrote the screenplays for "Stone Cold," "No Remorse," and "Innocents Lost," and supervised the screenplay adaptations of "Night Passage," "Death in Paradise," and "Sea Change." He lives in California.
Review quote
"No one understands what makes Bob Parker's Jesse Stone tick better than Michael Brandman, who help bring him to television.... I know Michael is just the writer to carry Jesse into the future." --Tom Selleck


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Narrow your search
The big news for iOS 8.4 is Apple Music, but there's a long list of tweaks and fixes to iBooks and more in the latest iOS update.
All the news from the annual Google I/O event, including the latest on Android.
The official Facebook app is, without question, the best way to access the social network from your iOS device.
Some people are complaining because they can no longer share music to their iOS devices, while others say the iCloud Music Library is making a mess of their local iTunes library.
The Facebook Camera app is a great stand-alone for uploading images and viewing photo feeds from Facebook. New features make uploading even better, but we still wonder why the features aren't offered in the official Facebook app.
What?! Best Chromebook deal ever! And it probably won't last long.
Polarr opted not to build an app specifically for Apple's iOS software, instead going the less-traveled route of using more-universal Web technologies. That decision is now paying off with droves of downloads.
After years resisting subscriptions, Apple hits play on a $10-a-month streaming music service Tuesday with a three-month free trial.
Technically Incorrect: In a Facebook Q&A, Mark Zuckerberg's intellect is tested by one of the world's great minds.
A core component in the rumored next iPhone will be a new Qualcomm-developed LTE chip that doubles its maximum potential Web-connectivity speeds, according to a new report.
Technically Incorrect: Perhaps one of the most dangerous accessories you can buy is now available.


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Educelerate + US DOE: Ed Tech Developer's Tour
- Business & Professional
- 1520 2nd St., Santa Monica, CA, 90401
Intro to the LA Startup Community
General Assembly
Thursday, May 9, 2013 from 6:30 PM to 8:00 PM (PDT)
Intro to the Los Angeles Startup Community
Thursday, May 9th from 6:30 pm to 8:00 pm
Sam Teller, Managing Director of Launchpad LA
Pizza and Beer will be served
This free class is an orientation to help newcomers to the startup scene get acquainted with the exciting world of tech in Los Angeles. We will canvas key events/meetups to attend, people, companies, VCs, blogs, hot issues, and more. After class you are welcome to network with a number of prominent folks in the ecosystem.
Sam Teller is Managing Director of Launchpad LA, a leading startup accelerator in Los Angeles. As Managing Director, Sam is focused on finding the best early stage companies and most talented entrepreneurs. Prior to leading Launchpad LA, Sam co-founded Charlie, a Los Angeles-based media company and interactive agency. At Charlie, he led new media strategy for top entertainment, corporate, and political clients, including Samuel L. Jackson, Tumblr, Rachel Zoe, and Dick Clark Productions. Before Charlie, Sam was a member of Barack Obama's presidential campaign and inaugural new media team. Sam was born and raised in Los Angeles and received a BA from Harvard College, where he was business manager of the Harvard Lampoon and wrote some of the earliest news stories about Facebook.com.
Can't make it? Sign up at https://generalassemb.ly/ to stay in the loop on events and classes.
In case this class reaches capacity, please RSVP for May 16th Intro to the LA Startup Community: http://www.eventbrite.com/event/6238667021
Join millions of people on Eventbrite.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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- Product Information
Product Description
Our totally 80's inspired gloves are perfect for any costume style. Our Fishnet Fingerless Gloves make a great "character" gloves and are a perfect accent to holiday costumes, too! Our Red Fishnet Fingerless Gloves are packed and price per pair. One size fits most. Please order in increments of 1 pair, per color. One size fits most.
- Questions & Answers
- Reviews
Minnie Mouse Birthday Party Ideas
Her birthday party will be a huge hit with a Minnie Mouse theme! Use these decorating ideas to help your put together the most adorable Minnie Mouse party.
1950s Sock Hop Party Ideas
Invite friends over for a rockin' good time when you throw a fifties theme party! Use these party tips to assist you in putting together the best sock hop anyone's ever seen.
Throw a Beach Party with these Helpful Beach Party Ideas
Plan a get-together on the beach, or throw a beach-themed bash in your home, using these fun beach party tips!


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Recently added to es.urbandictionary.com
ene 19
2. A renewed relationship with an ex.
2. A renewed relationship with an ex.
After they broke up, Joe still called Kate for some rebooty on weekends.
Por chittydog 04 de enero de 2007
ene 18
The knocking of fists together as a greeting, or form of respect.
He gave me a dap when we greeted.
Por Phil 10 de marzo de 2004
ene 17
Documents made of paper, like an anablog, in contrast to electronic documents.
Print out the treeware and we can send it via snail mail.
Por Blue Cawdrey 18 de noviembre de 2004
ene 16
To write a blog entry just for the sake of posting an entry, not because you have done anything interesting today.
I couldn't really think of anthing good to blog about, so my last post was real blogorrhea.
Por Dustin 19 de febrero de 2005
ene 15
The reverse of namesake; a person you are named after.
The monk Martin Luther was the nametake of Dr. King.
Por Ben Frey 17 de abril de 2006
ene 14
To shop for items online; to buy things from an online store.
I think I'm going to save myself a lot of holiday shopping hassles and just shop naked.
Por CleverConveyence 12 de diciembre de 2006
ene 13
To insert contacts in your eyes.
John said, "Slap your plastics and let's go to the bar."
Por JaaWeave 18 de diciembre de 2006