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#1 English for Business Studies.
16-11-2010, 04:40
English for Business Studies
Cambridge University Press | 2008 | 208 pages | PDF & MP3 | 146 MB
English for Business Studies is a course for upper-intermediate and advanced level students who need to understand and talk about the key concepts in business and economics. English for Business Studies is a course for upper-intermediate and advanced level students who need to understand and talk about the key concepts in business and economics.
#2 Systems Engineering: A 21st Century Systems Methodology
8-09-2010, 02:00
Systems Engineering: A 21st Century Systems Methodology
Wiley | 2008 | ISBN: 0470058560, 0470518758 | 528 pages | PDF | 7,1 MB
This book conceives, presents and exemplifies a contemporary, general systems methodology that is straightforward and accessible, providing guidance in practical application, as well as explaining concept and theory. The book is presented both as a text for students, with topic assignments, and as a reference for practitioners, through case studies.
#3 Understanding and Teaching Primary Mathematics
28-07-2010, 04:39
Understanding and Teaching Primary Mathematics
Publisher: Longman | 2010 | PDF | 272 pages | ISBN: 1405899506 | 5.8Mb
Understanding and Teaching Primary Mathematics is a full colour, core textbook for anyone training to teach Maths at primary level. A self-audit is provided at the outset to assess your prior knowledge and highlight areas for your personal development. The book will then help you to develop your mathematical understanding by encouraging you to think mathematically. You will be asked to create an action plan to aid your development and this will also allow you to build up a portfolio of evidence to help you achieve QTS (Qualified Teacher Status). Rather than treating subject knowledge and pedagogy as two separate entities, the book sets maths subject knowledge in context, showing you how to apply it in the classroom, through models and cases of best practice. Misconception boxes appear throughout each chapter to highlight common misconceptions children have in maths and help you to make connections between different areas of mathematics so that your pupils will see mathematics as a whole rather than a series of separate and often disparate ideas. Case studies in each chapter also provide you with an exemplar lesson plan annotated by a new teacher which shows you how to deal with a common misconception. This book will help you to deliver Maths at primary level in a clear and confident manner.
#4 The Human Pain System: Experimental and Clinical Perspectives
26-07-2010, 13:00
The Human Pain System: Experimental and Clinical Perspectives
Publisher: Cambridge University Press | 2010 | PDF | 648 pages | ISBN: 0521114527 | 14.6Mb
Pain is a subject of significant scientific and clinical interest. This has resulted both from realistic rodent models, and the publication of imaging, psychological and pharmacological studies in humans. Investigators studying rodents refer to anatomical and physiological studies in non-human primates to make their results relevant to humans. Psychophysical and pharmacological studies in humans are interpreted in terms of anatomical and physiological studies in animals; primarily evidence from rodents and cats. There are significant differences in pain mechanisms between these species and primates. Over 20 years of imaging studies have demonstrated the activation of human cortical and subcortical structures in response to painful stimuli. Interpretation of these results relies upon an understanding of the anatomy and physiology of these structures in primates. Jones, Lenz, Casey and Willis review the anatomy and physiology of nociception in monkeys and humans, and provide a firm basis for interpreting studies in humans.
#5 Madinah Arabic Book Series: Learning Arabic.
25-12-2010, 10:29
Madinah Arabic Book Series: Learning Arabic
Madinah Arabic Book Series: Learning Arabic | 110MB
The Arabic Course for English-Speaking Students is a comprehensive and popular course for the teaching of the Qu'ranic and Traditional Arabic, originally devised and taught at the renowned Madinah Islamic University catering for students from all over the world engaged in Islamic studies at the University.
#6 The Handy Geology Answer Book
27-10-2010, 14:56
Synchronization in Coupled Chaotic Circuits & System by Chai Wah Wu
World Scientific Publishing Company | 2002 | ISBN: 9810247133 | Pages: 188 | PDF | Size: 10,5 MB
This invaluable book studies synchronization of coupled chaotic circuits and systems, as well as its applications. It shows how one can use stability results in nonlinear control to derive synchronization criteria for coupled chaotic circuits and systems. It also discusses the use of Lyapunov exponents in deriving synchronization criteria. Both the case of two coupled systems and the case of arbitrarily coupled arrays of systems are considered. The book examines how synchronization properties in arrays of coupled systems are dependent on graph-theoretical properties of the underlying coupling topology. Finally, it studies some applications of synchronized chaotic circuits and systems, including spread spectrum and secure communications, coupled map lattices and graph coloring.
#7 U.G. Mathematics ; Short Questions and Answers
14-08-2010, 11:01
U.G. Mathematics ; Short Questions and Answers
Asian Books Pvt. Ltd | 2005 | ISBN: 8186299629 | 458 pages | PDF | 13 MB
This book titled U. C. Mathematics (Short Questions and Answers) has been written for the students of B.A., B.Sc. general course for all Indian Universities. All the efforts have been made to make this book useful for other competitive examinations. Though the book is of general nature but an effort has been made to cover up most of the topics prescribed for B.A.,B.Sc. general courses.
#8 Golden Book of Chemistry Experiments
30-07-2010, 15:13
Golden Book of Chemistry Experiments
Publisher: Golden books | 1960 | Pages | ISBN: 0307135748 | PDF | 27 MB
The Golden Book of Chemistry Experiments was a children's chemistry book written in the 1960s by Robert Brent and illustrated by Harry Lazarus. Many of the experiments contained in the book are now considered highly dangerous for children, and would not appear in a modern children's chemistry book. OCLC lists only 126 copies of this book in libraries worldwide. It was said that the experiments and information contained herein were too dangerous for the general public.
#9 Subject 13-RELOADED
29-05-2015, 07:14
Subject 13-RELOADED
PC Game | Publisher: Gravity Europe SAS | Developer: Paul Cuisset , Microids | 1.03 GB
Languages: English, French, Italian, German, Spanish
#10 Imaging in Percutaneous Musculoskeletal Interventions
7-07-2010, 05:35
Imaging in Percutaneous Musculoskeletal Interventions
Publisher: Springer | 2008 | ISBN: 3540220976 | PDF | 414 pages | 12.9Mb
This is one of the first books to deal specifically with imaging in percutaneous musculoskeletal interventions. In the first chapter, the basic procedures and different guidance techniques are presented and discussed. Ensuing chapters describe in exhaustive detail the abilities and uses of imaging in guiding procedures ranging from biopsy and joint injection to management of pain and tumors. The third part of the book documents the different indications for vascular interventions in musculoskeletal lesions. The final chapter focuses on ultrasound-guided interventions, as they are more common and tend to be fashionable. The book is well illustrated with carefully chosen and technically excellent images. Each of the 18 chapters is written by an expert of international repute, making this book the most current and complete treatment of the subject available. It should be of great interest to interventional radiologists and also musculoskeletal and general radiologists.
#11 How to Practice Evidence-based Psychiatry: Basic Principles and Case Studies
23-07-2014, 17:48
How to Practice Evidence-based Psychiatry: Basic Principles and Case Studies
English | 388 pages | ISBN-10: 1585623652 | PDF | 8.08 Mb
#12 General Theory of Irregular Curves
10-12-2013, 02:06
General Theory of Irregular Curves
English | 288 pages | ISBN-10: 9027728119 | PDF | 10.36 Mb
#13 The Handy Astronomy Answer Book (The Handy Answer Book Series)
6-08-2010, 15:44
The Handy Astronomy Answer Book (The Handy Answer Book Series)
Publisher: Visible Ink Press | 2008 | PDF | 332 pages | ISBN: 1578591937 | 7Mb
From planetary movements and the exploration of our solar system to black holes and dark matter, this comprehensive reference simplifies all aspects of astronomy with an approachable question-and-answer format. With chapters broken into various astronomical studies—including the universe, galaxies, planets, and space exploration—this resource is an ideal companion for students, teachers, and amateur astronomers, answering more than 800 questions, such as Is the universe infinite? What would happen to you if you fell onto a black hole? What are the basic concepts of Einstein's special theory of relativity? and Who was the first person in space?
#14 General Lee - Roads (2010)
10-12-2010, 00:53
General Lee - Roads (2010)
Genre: Atmospheric Sludge, Post Metal | Release: 2010 | Country: France | MP3 | 320 kbps | 144 MB
#15 Quantum Mechanics: Concepts and Applications
29-08-2010, 06:49
Quantum Mechanics: Concepts and Applications
Wiley,2 ed | 2009 | ISBN: 0470026782, 0470026790 | 688 pages | PDF | 16 MB
Quantum Mechanics: Concepts and Applications provides a clear, balanced and modern introduction to the subject. Written with the student's background and ability in mind the book takes an innovative approach to quantum mechanics by combining the essential elements of the theory with the practical applications: it is therefore both a textbook and a problem solving book in one self-contained volume. Carefully structured, the book starts with the experimental basis of quantum mechanics and then discusses its mathematical tools. Subsequent chapters cover the formal foundations of the subject, the exact solutions of the Schrodinger equation for one and three dimensional potentials, time-independent and time-dependent approximation methods, and finally, the theory of scattering.
#16 Economic Liberalization and Political Violence: Utopia or Dystopia?
8-08-2013, 23:21
Economic Liberalization and Political Violence: Utopia or Dystopia?
English | 360 pages | ISBN-10: 0745330630 | PDF | 4.49 MB
Globalisation is lauded by some as a tool for spreading peace and prosperity, and decried by others as a harbinger of conflict and war. This book challenges both views.
#17 Subject 13-RELOADED
31-05-2015, 16:40
RELOADEDhas released the new PC game "Subject 13" for Windows. Enjoy!
Description: This is a true adventure game. It depicts a mysterious universe filled with secret hiding places and all kinds of mechanisms that the player discovers, analyzes, and activates. There are also objects to collect and to figure out how to use in the backdrops...
Subject 13 will make you travel from a secret base that has been abandoned to a strange and mysterious island, so you can discover the real story. You'll have to muster all your insight and intelligence for this daunting challenge.
#18 Physics Without Math: A Descriptive Introduction
21-08-2010, 13:29
Physics Without Math: A Descriptive Introduction
Publisher: McGraw-Hill Companies | English | PDF | ISBN-10: 0070571732 | 366 pages | 15.56MB
Physics without math is written at a mathematical level that a bright 11 year old could understand. The subject matter is in enough debth that even students that have taken college physics before will gain new insights. Shapiro has a gift for showing the big picture where you really do follow the thought process. Most importantly however, if the book was dull, you would not read it even if it was very educational. This book is the one that I have been reading at night for fun. Now when I find that a book ends up on the bedside stand, and next to me while cooking, and at the table at meals...that book needs a positive review. Get this book, then after this one if you havent already read it get Hewett conceptual physics. If you enjoy reading science, then this book is for you.


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subset: commoncrawl


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1. In a wok on very high heat, pour canola oil and fry the egg. Stir in the garlic-ginger mince and rice.
2. Add mushroom, carrot and season with maggi seasoning sauce, salt and pepper.
3. Add green onion and mix well.
4. Remove from heat and transfer to a serving plate. Garnish with fresh lime, tomatoes and cilantro.
5. Serve the Fried Rice with tomato sauce.


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So apparently, Miss D.C is getting a double mastectomy...so she won't get breast cancer. A little paranoid, if you ask me. But that's just my opinion. I guess it depends on the situation and how willing you are to go through that voluntarily...
♥ "Don't care about all the pain in front of me'Cause I'm just trying to be happy." ♥
I guess I can understand a bit. She did lose her mother, grandmother, and great aunt to it. Kinda scary.
♥ "Don't care about all the pain in front of me'Cause I'm just trying to be happy." ♥
I just saw a car parked outside with 2 stuffed Peas in a Pod from TS3 in the back. Awwww... I wonder who the Pixar fan might be?
Miss D.C. Allyn Rose pursuing double mastectomy after Miss America pageant | WJLA.com
♥ "Don't care about all the pain in front of me'Cause I'm just trying to be happy." ♥
how come i can do everyon else's signatures fine, everything comes out great for everyone else .FINE!! i changed out to the one i am currently using in my own email, ugh i wanted my cinderella one, but the glitter wasn't coding right or something. i am sure the jessica rabbit will be to racy for the boards. so when i get home it will be changed out. some of my best works weren't for my self but people on this board.. but i can't seem to get anything right this week for my own!! LOL what's wrong with me!?? LOL
Last edited by Poisonedapples; 01-11-2013 at 01:51 PM. Reason: rrrrrrrr!! darn darn!
ookay kinda sick of the dumbo walt disney resort add.. really.. and oh the bush baby one needs to go.. lol
I got a Target ad earlier- like I need a reminder to go spend more money there!
i'm swamped with work, Sara, imagine that!
I don't see any ads, since Safari blocks them.
Disneyland Here I Come Again!
October 1, to October 6, 2015


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Kobe Bryant, LeBron James among ESPYs nominees
Updated: June 24, 2010, 3:57 PM ETBy ESPN.com
Drew Brees, Kobe Bryant, LeBron James, Jimmie Johnson and Albert Pujols will vie for the Best Male Athlete award at the 2010 ESPYS, which are set for July 14 in Los Angeles.
Maya Moore, Diana Taurasi, Lindsey Vonn and Serena Williams are the nominees for the Best Female Athlete award. The nominations were announced Thursday.
The ESPYs will be hosted by Saturday Night Live's Seth Meyers and televised live (9 p.m. ET, ESPN).
"Am I nervous? Of course. ...
Read full story
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1883-CC $10 AU53 PCGS. Variety 1-B....
2012 January 4-8 US Coins & Platinum Night FUN Signature Auction- Orlando #1166
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Orange County Convention Center
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|Printable auction results for all items in the 2012 January 4-8 US Coins & Platinum Night FUN Signature Auction- Orlando.
Flashy AU53 1883-CC Eagle1883-CC $10 AU53 PCGS. Variety 1-B. Ex: Rainy Day Collection. Most immediately noteworthy about this briefly circulated yellow-gold eagle is its reflective luster, which is most persistent in the protected areas around the peripheral lettering. Excellent definition with strong eye appeal despite scattered small marks customary for the lightly circulated grade. The Rainy Day pedigree on PCGS-graded gold coins became a common sight on the bourse floor circa-2000. Population: 15 in 53, 17 finer (11/11).
Just 12,000 Pieces Struck
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Ex: Dallas Signature (Heritage, 10/2009), lot 1538, which realized $2,760.(Registry values: N2998) (NGC ID# 2667, PCGS# 8700)
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Julia Marino says she's grateful for Paraguay's 'love, support' - 0 Comments
KRASNAYA POLYANA, Russia — Freeskier Julia Marino wiped out on her final jump of the slopestyle competition and — her Olympic dream at an end for now — had to make a heartbreaking climb back up the hill to fetch her skis.
But for the Winchester, Mass., resident, it remains a worthwhile journey.
Born in Paraguay, Marino was adopted as a toddler and grew up in Massachusetts. She might have tried to compete for the United States, but chose to represent Paraguay.


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Starwest Botanicals, Coriander Seed Whole, Organic, 1 lb
By Starwest Botanicals5 Reviews
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Discover the highs and lows of Gebrselassie's extraordinary racing career.
Ethiopian long-distance track and road athlete Haile Gebrselassie has announced his retirement from competitive running. The 42-year-old confirmed his decision after the Greater Manchester Run on Sunday.
In one of the most successful running careers of all time, over the past 25 years Gebrselassie amassed 27 world records, two Olympic medals and eight world titles.
We've trawled the archives to find some of the career highs and lows faced by the world's greatest distance runner, to relive the moments that made Gebrselassie the running legend he is today.
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Amazing, I grew up watching this great man and he was a great influence on me getting in to running and then triathlons.
Great to see him get the massive respect he deserves, could have delved deeper back to his humble beginnings and what he does for his country and running in general, but what a brilliant man. If he retires, then they should erect monuments in his name.
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Messerschmitt Bf 109 E-3
www.FightToFlyPhoto.com Enjoy the incredible sights and sounds of Flying Heritage Collection's Messerschmitt Bf 109E-3. This aircraft is a Battle of Britain veteran and is powered by a Daimler-Benz 601 engine.
Roskilde Airshow 2013, Messerschmitt Me 109 G-4, the flight
The rare Messerschmitt Me 109 [Red 7] seen on the ground and in the air on saturday the 17th of August at Roskilde Airshow 2013 in Denmark. All though the pictures are far from perfect you can enjoy the fantastic sound from that machine in the air. App. 95% of the total flight is recorded in this video. In the show the next day it did make an emergency landing in a cornfield near the airport. Luckily with no harm to the skilled pilot Klaus Plasa, and only minor damage to the plane. The plane is own by EADS - a huge european aerospace organisation and has home at Flugmuseum Messerschmitt (Messerschmitt Stiftung) near München. There exist only very few Me 109 mounted with the original Daimler-Benz DB-605 engine. The plane itself is not quite original as it is licence build in Spain in 1950. The plane have participated in the famous movie The Battle of Britain and has crashed several times during its long life. News May 2014: The accident report from the belly landing have been published in May 2014 and reveal why the engine did stop in the air on that Sunday. The reason was that this Me109 is not intended to do negative G flight, for example, level flight upside down which the airplane did immediately before the engine stopped. In the plane's Flight Manual, there was no restrictions about that, and therefore the pilot could not know about that limitation. Restriction markings regarding negative G fligh is now put into the Flight Manual. News May 2015: The plane has now been repaired and is flying again. In addition, it has now been published that the Red 7 once more will participate in the big national airshow in Roskilde Denmark in 2015. It is the same airshow where the plane unfortunately had to belly land in a cornfield in 2013.
Bf109 G10
Walter Eichhorn fliegt die G10 der Messerschmittstiftung Daimler Benz V12 "DB605 D" mit ca36ltr Hubraum und 1435-1850 PS je nach Ausführung (Normal/superbenzin) und/oder Wasser/Methanol Einspritzung (MW50) 3Ventiler; Benzin-Direkteinspritzung; barometrische Ladedruckregelung
Flying Bf 109 G-4 Red 7 / Restored after Roskilde Airshow crash. Fly with the pilot / MUST SEE!!
Ready for take off. Accompany the pilot in a Me 109 G4. Watch inside the cockpit what is going on while starting, during flight and landing. Unique pictures of a legendary Aircraft in action. The complete flying display at http://flugmuseum-messerschmitt.com Begleiten Sie den Piloten einer Me 109 G4 beim starten, während des Flugs und bei der Landung. Einzigartige Bilder einer legendären Maschine in der Luft. Das komplette flying display finden Sie auf http://flugmuseum-messerschmitt.com


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Beach blanket lo-fi pop from Bethany Cosentino, (ex-Pocahaunted). Inspired by Bethany's longing for Los Angeles while spending her days in NY attending Eugene Lang College, Best Coast sprung forth during her first days back in California. You can expect songs about summer, the sun, the ocean and being a lazy creep, with drums, Beach Boys-style bass lines, and other amazing things added by her friend Bobb Bruno.
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Fairfax County welcomes illegals, but threatens to sue the Army
Enough Obamessiah, people. Via a long chain of blogs I ended up at this post, which points out an interesting contrast in the priorities of the lovely Fairfax County, VA.
This week, the Fairfax County School Board threatened to sue the Army:
The top elected school official in Fairfax County said the system may sue to force the Army to recognize that an upcoming job influx at Fort Belvoir will bring a flood of new students.
Ok, I understand that Fairfax County is just trying to shake down the Federal Government for as much money as it can get. That's ugly, but hardly unprecedented. But they need to understand how bad it looks when they welcome illegal immigrants with open arms, but give the cold shoulder to the Army.
You see, as discussed before on this blog, Fairfax County is a sanctuary county for illegal immigrants. When asked about his stance on illegal immigration, Board of Supervisors Chairman Gerald Connolly explained, "I can just tell you Fairfax County is not going to go the route of some of our neighbors. We're not going to demagogue. We're not going to essentially roll back the welcome mat."
Now, the Gerald Connolly quoted there didn't necessarily have anything to do with the threat to sue the Army.
But he is running for Congress.
Connolly's Republican opponent, Keith Fimian, runs a website here. I don't know Fimian's views on illegal immigration and sanctuary…but I know his opponent's.
ELECTION IS JUNE 10th, Virginians.
P.S. If Fairfax County is so strapped for cash they're shaking down the Army, I can suggest one Fairfax County cop they could let go.
{Post by See-Dubya. Hat tip to Snapped Shot (who has more) and Black Velvet Bruce Li.}
Why America Hates the GOP-Obamatrade Deal
June 12, 2015 12:15 AM by Michelle Malkin
5th Circuit Court sides with Obama 2008-2013™ about constitutionality of Obama 2014-2015™ executive amnesty
May 26, 2015 09:19 PM by Doug Powers
SleazeBob Menendez's 36DD visa program
April 21, 2015 09:32 PM by Michelle Malkin
The green card racket for Beltway cronies
April 1, 2015 02:40 AM by Michelle Malkin
The big, fat "American recruitment first" lie of H-1B
March 18, 2015 10:17 PM by Michelle Malkin
Categories: Feature Story, Immigration


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I did it you all! I got fit for the summer season and I'm ready for all the summer activities. It's amazing how great it is to feel so good about yourself when your fit. I'm talking about mind body fitness. It's been almost one year since I stopped dieting and I've never felt better. My mind has ... READ MORE >>
5 Reasons Why I Love Green Smoothies and You Can Too
On the occasion when I don't have my green smoothie, I can feel a difference in my body, so for that reason alone, I'm going to tell you the 5 reasons why I love green smoothies and you can too! Maybe you'll fall in love with green smoothies once you notice how amazing you can feel. I'm always ... READ MORE >>
Loving My Body in the Pursuit of Happiness
As I'm sitting here writing this post I had a thought, "Oh, I haven't eaten in awhile, I should probably go eat." But then I checked in with my body - something like this, "Am I hungry? Do I feel hungry? Are there any hunger pangs?" The answer was "no". I am somewhat amused that I kept ... READ MORE >>
Embracing Uncertainty Transforms My Relationship with Food
Today I discovered how embracing uncertainty and the discomfort that comes with it has allowed me to release the outcome in life and transform my relationship with food. For most of my life, at least adult life, I've worried about the outcome of events and would always try to mitigate the details ... READ MORE >>
My No Diet Days Are Making Me Lose Weight
Whah? Losing weight without dieting? Huh? Yep, you heard me right. My no diet days are causing me to lose weight and feel pretty amazing - like I have this freedom I've never experienced before. Who would have ever known that not dieting could create weight loss. I didn't know how to lose ... READ MORE >>
Apply for Free Holistic Health Coaching to Transform Your Relationship with Food
I was going to start this post out with a very clever, and very sterile reason, about how to transform your relationship with food, but dang it - I'm just going to be bold and speak quite frankly. Aren't you tired of diets? Aren't you tired of all the the conflicting information out there that ... READ MORE >>
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93 reviews
By installing you agree to the Terms of Use and other terms
PublisherMicrosoft Research
More from Microsoft Research
Download size3 MB
Last updated2/13/2015
Works with
- Windows Phone 8.1
- Windows Phone 8
App requires
- contacts
- phone identity
- video and still capture
- music library
- media playback
- microphone
- data services
- push notification service
- movement and directional sensor
- web browser component
- HD720P (720x1280)
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Supported languages (1)
English (United States)
Create and share fun, temporary messages and media with friends using WindUp. Decide how long a message will last - set it to expire after a time or view limit of your choice. Set a low limit to "wind up" your friends as they race to see what you've posted, or set the limit high to make your message last longer. WindUp lets you share pictures, videos and audio snippets, as well as text.
7/1/2015Guess what it want even let me make a story and that's lame they need to put Snapchat back on here like Fr cuz this app wack😂😒 ✋ 😊
6/17/2015One of best app I used! 😊 hope its also comes to ios & Android. Better than snap chat 👍 please add me firstname.lastname@example.com
5/9/2015The app in itself works fine, but I have ZERO friends. Who am I going to talk to, what's the point. Please work on Snapchat? Also, add me email@example.com
5/2/2015WHY NOT SNAPCHAT! Please this is my request to Microsoft to provide us snap chat or any app compatible to it PLEASE. I regret taking windows phone just because of it!
4/25/2015Just get over the snap chat dispute it's so petty.
4/7/2015STILL NOT SNAPCHAT. Good app with cool functions but what's the point if I don't have anyone to send anything to??? This rating is based purely on the app itself. If I rated base on it's true social function, zero stars. No point if you don't actually have friends who use it. Extend to SnapChat platform and users will be happy!!!
3/27/2015I miss snap chat and I have no friends. Someone add me?? email@example.com
2/24/2015The app itself is very nice, but could it not save taken photos? Kind of a hassle to have to delete them from my phone afterwards.
2/24/2015No. Just make a deal with Snapchat. Stop limiting us to just your company and monopolizing the people who use your products.
2/22/2015Login fail


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The Top 10 In Action Sports
01Sam Pilgrim vs. The World: The Champion Aiming To Reclaim His Crown In A New Era Of Biking
02Eccentric Adventures Episode 2: Britain's Most Brutal Illegal Event is All About Cheese
03A Journey Into Darkness: We Went Mountain Biking in the Abandoned Mines of Slovenia
04After the Apocalypse: Inside The World's Most Breathtaking Ghost Towns
05Debate: Let's Stop Hating On Parents Who Want To Raise Adventurous Kids
06Guns, Roses, And Eating Insects: Adventure Cycling in Vietnam
07From Intense Trails to Intensive Care: Dicing with Death In a Mountain Biking Paradise
08Lifting The Veil: The Truth About Women's Snowboarding In Iran
09Holy Waters: Kitesurfing Amongst Pilgrims in India
10Cool Runnings: Is Jamaica Mountain Biking's Best Kept Secret?
KEEP SNOWBOARDING 2013: The ROCKET
A Snowboarding video by snowboardermbm - 3,069 views
As you already hight have heard the motto for this year's KEEP SNOWBOARDING camp at Snowpark Grasgehren, Germany, was the lunar landing. That's why the guys at UNIT Parktech built a giant rocket for us. The riders really liked the idea and kept on shredding all evening...
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over 3 years ago
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Qt but not "on the Q.T.": Nokia Renames Trolltech
Not only is the cross-platform Qtopia application framework now called Qt Extended in its current version, but Nokia has renamed recent purchase, Trolltech to Qt Software.
As the Norwegian company announces, the Linux-based Qt Extended is now available in version 4.4. Enhancements include a modular architecture, an improved user interface for touch screens, and real time communication through Telepathy based on the Extensible Messaging and Presence Protocol (XMPP).
Trolltech announced end of September that it is now fully integrated into the Nokia Devices unit as Qt Software.
PronunciationThe way everyone at Trollte- .. er.. Qt Software says it is "cute". =)
Yes, but how do we pronounce it?Is it "Kyew Tee" or "cute"
Issue 177/2015
Buy this issue as a PDF
RIP SSLv3
The Internet community officially banishes the notoriously unsafe Secure Sockets Layer protocol.
Mate 1.1 Arrives
Popular desktop environment continues the Gnome 2 legacy – with new support for the Gnome 3 toolkit.
US Government Requires HTTPS
The Obama White House has issued a memorandum telling all US government agencies they must use HTTPS for all websites and web communication.
Mozilla Signs Firefox Add-Ons
New program will dial up security for the Firefox browser.
Fedora 22 Arrives
Red Hat's community distro embraces the cloud.
Code.org and College Board Team Reach Out for Talented High School Coders
New partnership will bring more and better CS training to US schools
A Peek Inside TeslaCrypt Ransomware
Criminals offer online help over Tor network
Mumblehard Still Spams
Sophisticated malware is still present on Joomla and WordPress sites around the world.
Launchpad Gets Git
Future versions of Ubuntu's code service will support the popular Git version control system used with Linux and other open source projects.
AMD Posts Code for Linux GPU Driver
New release marks the arrival of AMD's unified driver strategy.


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School of Nursing: Celebrating Nurses
Past, Present, and Future of Nursing Education
George Mason University's School of Nursing 40th Anniversary Celebration will be held October 10-11, 2014 at the George Mason University Fairfax Campus in Fairfax, Virginia. Read more.
Take the next step in your professional career at George Mason University's School of Nursing. For career-minded professionals, we have programs that fit your need and work around busy work schedules.
As an RN, you can complete your BSN degree in as little as two semesters with an online program. We offer blended online and classroom degree programs that allow flexibility around work schedules for students seeking MSN or doctoral level (DNP or PhD) degrees.
The journey begins with a single step. Start it with us.
Take the next step.
Click the thumbnails to view more images.
Spring Preview was bustling with a number of admitted students in the class of 2019 to learn more about our programs. Admitted students in the School of Nursing toured the labs and eagerly jump started their nursing skills by examining Seth, one of our clinical simulators. They had their first clinical success and we look forward to seeing them in the Fall.
If you are ready to try your own skills out and be a part of Destination Mason, School of Nursing, visit our admissions website.
April 15, 2015 - In the developing country of Swaziland, the burden of disease currently results in a life expectancy of 52 years of age for its citizens. Compounding the problem is a lack of access to quality health care, trained healthcare workers, and strategic healthcare policies. Despite these challenges, Bongani Sibandze, a Ph.D. Nursing student, envisions a country where the burden of preventable diseases will be decreased or eliminated, and people will have access to necessary healthcare. Learn more about Bongani.
March 31, 2015 - Students from CHHS and CHSS recently won the People's Choice Award at the Caregiver Hack Design Challenge. The team designed "The Family Room," a site where family members can keep up with primary caregivers and older adults during the caregiving process. The award winning team included students from the School of Nursing, Department of Global and Community Healthy, Department of Health Administration and Policy, and Department of Psychology (CHSS). Read more.


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Calvin Harris at LIV Nightclub June 7
From underground electro-pop to mainstream success as one of dance music's biggest names, Calvin Harris has enjoyed a rise to the top that's been quite the whirlwind adventure. And though he's not the richest man in the world, his hard work has paid off handsomely.
Sure, he isn't exactly swimming in freshly minted gold coins. But the Scottish-born, London-based DJ, singer, and producer has banked a hefty chunk of frequent-flyer miles. And in a time when airline fees are astronomical, every perk counts.
However, a grueling travel schedule and some stage fright nearly got the best of Harris a few years ago. "I've stopped the live shows," he told Australia's Herald Sun in 2010. "I'm not a singer, I'm not trained. Taking it onto the stage in front of people was terrifying. I got much, much better at it. But I never lost the terror."
That's why instead of personally singing on tracks (as he did for his debut album, 2007's I Created Disco), Harris outsourced the vocals. He told the Sun: "I'm going to focus slightly more on production and DJing, and zero percent of my time will go on singing. I'll do tracks with people who can sing well: proper artists, proper performers."
So expect Harris to be doing what he does best — DJing — this Thursday at LIV. As for the vocals, he'll just press play.
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- Trailer #20 released about our upcoming tour; makes you wish it started RIGHT NOW!
- Trailer #19 out today!
- South America & Mexico Tour announced
- Making-of video #18 revealed!
- Vizovice, CZ Masters of Rock
- Tokaj, HU Kingdom of Hegyalja Festival Tickets
- Barcelona, ES Rock Fest BCN 2015
- Oulu, FI Qstock
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South America & Mexico Tour announced
South America and Mexico, we're coming your way! 25 SEP - RIO DE JANEIRO, Rock in Rio 26 SEP - SÃO PAULO, HSBC 29 SEP...
Announcing the Australia 2016 tour
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Proud to announce our "Endless Forms Most Beautiful – Europe 2015" tour!
In anticipation of our upcoming new record we can proudly announce the "Endless Forms Most Beautiful - Europe 2015"...


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Poor tenant screening procedures can be very costly. They lead to high tenant turnover, eviction expenses, vacancy rates and maintenance/rehab costs. It will decimate the return on a property. That makes it all the more shocking that so many property … Continue reading
Fruit Salad and Property Management
So, you own a home in metro Atlanta and need property management from a great property manager but you are just not sure who to use. You decide to google "property management in Atlanta", call the top 5 real … Continue reading
Regain Your Sanity – Bravo Group Property Management!
So, you need a property manager in Atlanta. Sure, you can continue managing your rental homes yourself but the late night maintenance calls, endless rent collection calls, eviction process, move ins, move outs, home showings, forever back and forth with … Continue reading


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YIELD: Makes 4 servings
ACTIVE TIME: 20 min
TOTAL TIME: 40 min
Toast fennel seeds in a heavy medium saucepan over medium heat, stirring, until fragrant and a shade darker, about 2 minutes. Add water and 3/4 teaspoon salt and bring to a boil. Add rice and return to a boil, then cook, covered, over low heat until water is absorbed and rice is tender, 18 to 20 minutes. Spread rice in a shallow baking pan and cool quickly by chilling, uncovered, 5 to 10 minutes.
Meanwhile, grate zest from orange into a large serving bowl and squeeze in juice (about 1/3 cup). Whisk in vinegar, oil, 1/4 teaspoon salt, and 1/4 teaspoon pepper.
Chop 2 tablespoons fronds from fennel, then discard stalks. Quarter bupound lengthwise and thinly slice crosswise.
Stir fennel bupound and fronds into vinaigrette along with cooled rice, scallions, and salt and pepper to taste.


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Thanks to those who helped me with some of my previous questions. I've been able to figure out some things and decided to just live with others but I can't go live until I get answers to eliminating the big space at the bottom of my text boxes and how to make hyperlinks work in text boxes. An ETA on these please.
Overall, I think the DMS support forum is clumsy and that perhaps subcategories are in order.


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495 Tasting Notes
Hmm, I'm confused about this one. It does not smell or taste like a charcoal roasted oolong. It's seems extremely similar to an oriental beauty and if it is, then its a really good one (and that means something as I am not a big fan of oriental beauty). However, the leaves for this are tightly rolled unlike those of oriental beauty, so I dunno what to make of it.
Either I got the wrong tea in the package or this is a style of roasting that I am completely unfamiliar with. At any rate, it is a good tea, whatever it is! :D
I just did a second steep for 45seconds (first was 1min15sec) and the flavor is significantly different than the first steep. I can now recognize the characteristics of a roasted oolong, but still not as strong as I thought it would be. In the first steep, I didn't detect any of the smoky notes that it is supposed to have. I only detected honey with a hint of floral, much like oriental beauties I have had before, but it had a distinct nutty attribute that made it different. The second steep brings out hints of all that I expect from a heavier roast, but they are not all in-your-face.
I wouldn't mind having more of this tea in my cupboard, but quality teas are pricey and I am saving my funds for Mantra Tea's über-awesome Ruby Black. We'll see how disciplined I am with my money when the time to order comes around :p
Shelley you are substantially correct, as this one is not nearly as heavily roasted as the TGY. I would recommend trying it cold brewed before giving up though :)
We placed 5 grams in 500ml of mineral water, left it in the fridge for three days. It was magical then.
PS have to thank you again for so conscientiously brewing and reviewing our teas.
I still have a lot to learn about teas :) I had expected this one to be heavier roast than the tieguanyin, so that was a surprise. I liked this one too though, it was just not what I was expecting when I brewed it this morning. I still have the leaves waiting for a second steeping and I'll update my thoughts then. People are always recommending that I cold brew teas, but as many of my followers know, I don't like cold tea. Call me weird, but I just don't like to ice my teas (or my coffee). It might seem the thing to do in summer, but there is a reason that fall and winter are my favorite seasons (^^)
I brewed this again today, just as I said I would. I followed these steeping guidelines posted on the Mantra Tea website:
water temp 95C
1st 70sec
2nd 30 sec
3rd 60 sec
4th 120 sec
I stopped at 4 steeps.
The 70sec steep produced a decadently sweet cup. The sweetness came through like raw cane sugar and caramel, though the floral notes from whence they likely came were still on the nose.
The 30sec steep brought the roast flavor into full effect, but not so much as to drown out the flavors from the first steep
The last two steeps lost most of the sweetness, but added hints of mineral as do all teas when I steep them more than twice, but they were not as strong as I am used to in a 3+ steeping.
I liked this tea a lot more this time around, but only for the first two steeps. I would be very unlikely to try for more in the future. I think my perfect cup would be a single steep in a mug for about 2 min (when I brewed this yesterday, I did it for 3 minutes).
I've had two tieguanyin teas before, both of the very green variety. I didn't know that iron goddess was traditionally a roasted oolong until now.
The flavors of this one are quite different from other roasted oolongs that I have had. I am quite fond of super dark charcoal roasted oolongs and haven't yet decided where this fits in with my personal preferences.
To better explain the character of this tea, I will relate to you my family members' responses:
My husband hasn't yet liked any roasted oolong that I have served him. He can't stand the smell of them and says that the flavors are only slightly better. I gave him a sample of this Iron Goddess tea, not at all expecting a positive response, but was surprised when he told me that he gives it a rating of "90." Really, I don't get it. I mean, it's different, but not that different, from the other teas that he has tried. . .
My mother, who has a liking for most roasted oolongs, said that she can detect some floral notes through the roasted flavors and that it was a very nice change of pace from what she is used to.
My father and I are about the same in our preference for a heartier roast, but we both enjoyed this tea. I am going to brew the rest in my gaiwan tomorrow and get to know it better before deciding if it will be a repurchase.
I was trying to decide which of my Mantra Tea samples to brew first, and this is the one I picked. I'm taking the Iron Goddess to share with my family later this evening.
Onto the tea:
This is an exceptional black tea. I've had a ruby black before, but it was not like this one. I don't at all have the tea vocabulary and trained palate to describe it properly, but I can say for sure that you all have to try this! It's not bitter and astringent, but I certainly wouldn't call it a delicate black either. It's so smooth! I can definitely detect the woody flavor noted in the description as well as a a sweetness that I don't recognize as orchid, but it could be. I'm also not picking up specifically on notes of peppermint and cinnamon, but I can definitely see how this tea would be a good match for an afternoon tea cake that includes these flavors. This tea is definitely going on my re-order list :)
Another excellent roasted oolong. This one seems a lot more bold than others I've had. It packs a lot of flavor in each sip.
It's been a while since I brewed the 1991 aged oolong from Butiki, so my memory could be wrong, but that one seemed a bit sweeter than this one. I love both of them, though!
Black tea and mint is a favorite blend of mine, but I haven't tried one with an assam base before. I have some mint leaves that I add to my own teas sometimes, but I've always thought assam wouldn't be a good match. Apparently it is! This is my favorite mint and black blend yet.
Well, it must be perfect since both of my parents loved it too! My father isn't too keen on mint teas. Not that he dislikes them, but they don't usually get him too excited. I told him I brought a mint tea this evening and he just said "oh." But then, there he was asking for seconds and then acting real distraught when his cup was empty again. :) Assam and mint is a perfect pairing and you found just the right ratio of both.
This tea isn't half bad. Thanks for sharing it with me CK!What appeals to me is what many others here considered a flaw of sorts. It's not an in-your-face dessert tea. The black base is bold and the white chocolate only adds a slight change of texture and a touch of sweetness.
I tried this one again today with a longer steep time (8min30sec). This resulted in a much bolder flavor, but I didn't notice anything particularly different aside from this. I didn't get any of the coconut-like aftertaste this time around, but I am nearly certain that was caused by the cookies I had last time rather than by the tea.
I shared this brew with my family. My father said it went well with dinner and my sister said it tasted like burnt coffee (she hates coffee and I'm having a heck of a time finding any tea she likes either, so I wouldn't take her opinion too seriously. LOL)
I got this tea mostly so that my mother could try it. Of course, I had to sample it myself, but didn't expect to like it since I don't like Jasmine. It turns out that it wasn't as bad as I expected, though I still won't be purchasing this for myself in the future. The jasmine is subtle, hence why I could enjoy my cup at all. It tastes much like a delicate floral oolong with a creamy vegetal base. I've been advised that a second steeping will bring out the pine needle, but I only took a first steeping in a thermos to my parents house (one of the last few times I will be doing this because they are moving this week).
My mother liked it (she loves jasmine), so that is what matters :) She said it is a very calming/relaxing tea.


text:
Our staff is dedicated to serving the NAEM community. Please contact us directly with questions, comments or suggestions.
Under Carol's leadership, NAEM has grown from a small group of environmental managers to the largest professional community for corporate EHS and sustainability decision-makers. Contact her at email@example.com.
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NAEM launched the latest stage of its benchmark of the EHS and sustainability profession Wednesday with a survey to capture the behaviors and attributes that are required for professionals at each level of their career.
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Your doctor will ask questions about
your medical history and your symptoms. It is important to tell your doctor if
you have taken any recent trips or have been sick lately. Your doctor may also
ask about your sexual history to see if it's possible that you have had
herpes simplex virus.
If your doctor
thinks that you may have
encephalitis, lab tests usually will be done to
confirm the diagnosis.
An analysis of the fluid in
the spine (cerebrospinal fluid) is one of the most important tests in
diagnosing encephalitis. Samples are taken during a
lumbar puncture (spinal tap), in which a needle is
inserted in the lower back between the bones of the spine. The spinal fluid is
examined for evidence of infection, such as increases in white blood cells and
protein. In the case of
herpes simplex encephalitis, doctors can test for
traces of the virus's genetic material. Also, your doctor may do a
viral culture to identify the virus causing
encephalitis. For a viral culture, a small amount of the fluid is placed in a
container with other cells that grow a virus. It may take several weeks before
the results of a viral culture are known.
Magnetic resonance imaging (MRI) of the head may be used to detect specific areas of
inflammation or bleeding in the brain caused by
encephalitis. But most people with encephalitis have normal MRIs.
Another imaging test,
computed tomography (CT) scan of the head and face,
also may be used to see these changes in the brain. A CT scan uses X-rays to
take pictures of the brain. See a picture of a
CT scan of encephalitis.
Testing for
antibodies in the blood can identify some causes of
encephalitis, including mosquito-borne viruses and the viruses that cause
mononucleosis (Epstein-Barr virus),
cytomegalovirus, and
electroencephalogram (EEG) can help confirm a
diagnosis of encephalitis. An EEG records electrical activity in the brain
through wires (electrodes) taped to your head and hooked up to a computer. If
you have encephalitis, the EEG may show an abnormal increase or decrease in
electrical activity. But an EEG does not indicate whether the abnormal
electrical activity is caused by encephalitis.
biopsy sometimes may be used to find the cause of
encephalitis, especially if herpes simplex encephalitis is suspected and you do
not appear to be improving after treatment with acyclovir (an antiviral
medicine used to treat the
herpes simplex virus). An MRI may also help guide the
doctor in determining which tissue to biopsy should a biopsy be needed. Using
MRI to guide the biopsy needle, the doctor removes a small sample of brain
tissue and examines it for viral infection. Brain biopsy is seldom used because
tests of blood and spinal fluid usually can accurately diagnose encephalitis
caused by the herpes simplex virus.
Last Revised:
August 5, 2008
Healthwise Staff
Medical Review:
E. Gregory Thompson, MD - Internal Medicine & W. David Colby IV, MSc, MD, FRCPC - Infectious Disease
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Western Digital Caviar Green 500GB, SATA 6Gb/s (WD5000AZDX) saved
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Celebrity Central / Top 25 Celebs
Naomi Watts
Credit: Jen Lowery/Splash News Online
Published: Saturday February 01, 2014 14:00 PM EST
More from PEOPLE
Latest News!
- PHOTOS: Jill (Duggar) Dillard Shares Sweet Family Moment with Son Israel
- Read the Cover Story: Growing Up Kennedy!
Exclusive Family Photos from White House Nanny
- Facebook Photo Helps Mother and Son Reunite, 15 Years After He Was Kidnapped: 'It's a Miracle'
- Kim Kardashian West: 'I Don't Do Fillers or Botox When Pregnant'
- Kourtney Kardashian Steps Out as Photos Surface of Scott Disick Getting Cozy with Another Woman


text:
The Find Your Pirate Personality Test
Dread Pirate Roberts
All possible test results
What were you thinking taking this test. I am surprised that the sight of a ship doesn't make you seasick. Get off the ship, move as far from the sea as possible before a real pirate finds you! Read more
Dread Pirate Roberts
You left to make your fortunes so that you and your sweet Buttercup could finally be together. By fate intervened in the form of the Dread Pirate Roberts. He would have killed you if it wasn't for t... Read more
John Rackam
John "Calico" Rackam (????-1720). You spent 4 successful years pirating, but are mostly known for adding the women Mary Read and Anne Bonney to your crew. Your nickname came from your love of wearin... Read more
Jack Sparrow
You have lost your ship, been marooned on an island and called the worst pirate ever. Yet you still seem to pull through no matter how insane everybody else thinks you are. You come across as almost... Read more
Sir Henry Morgan
(1635-1688) You did it all for the glory of England (and yourself). You rose through the ranks with dedication and daring. But when peace broke out, you continued to plunder the hated Spanish and c... Read more
Yellow Beard
Its all about being a pirate. You rape the Gold, kill the Women, and steal the men. Or is it rape the men, kill the gold, and steal the woman or something like that. Your proudest day in life will ... Read more
Cheng Shih
(1775-1844) You may have been a woman and a prostitute, but that did not stop you from becoming the most powerful pirate ever. At one time you commanded more than 1500 ships and 80,000 men. You des... Read more
Captain Barbossa
You wanted it all, wealth and power. First you mutiny and take the ship. Then you hunt down and find the treasure of a life time. Damn the curse. But now you suffer from it. Your lust cannot be s... Read more
Mary Read
(????-1720) You took to dressing as a boy to deceive your grandmother into giving you money out of necessity. This led to a life in the military and eventually to ship life. Your secret remained unt... Read more
John Hawkins
(1532-1595) You made a name is the slave trade and then turned your eye on the Spanish colonies all in the name of Queen and Country. You were dedicated to the throne to the point, you even turned ag... Read more
Captain William Kidd
(1645-1701) You were a loyal servant to the crown. Dutifully attacking your enemies and turning the spoil over to your country. But soon you got to liking the killing and plundering to much and bega... Read more
Anne Bonney
(1697-17??) You left your husband and children to take up the life of a sailor. Dressed as a man, you terrorized the hi seas with your love John Rackam. Your reputation for cruelty and violence bec... Read more
Sir Frances Drake
(1540-1596) You learned from Jack Hawkins to sail the seas and shared many exploits with him, smuggling goods into the Spanish colonies and raiding ships and towns that did not want to barter. This e... Read more
Batholomew Roberts
Batholomew "Black Bart" Roberts (1682-1722) Your adventures included capturing 22 ships at one time. You were educated, well groomed, sophisticated. You carried your own musicians onboard, never dr... Read more
Captain James Hook
Your love for wealth and power is matched only by your love of killing and torture. But no matter your best laid plans, you have the fly in the proverbial ointment in the form of a boy. You will go ... Read more
Black Beard
Edward "Black Beard" Teach (1680? - 1718). Your past is mostly unknown, but your final years made you the most notorious pirate of all time. Your frightening appearance and reputation for killing al... Read more
Recent Results
swagnemite18 / m / Bisexual
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Quel PETRUS êtes-vous ?
Quel Petrus êtes-vous ?
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Are you Dorien M de Groot?Claim your profile
Publications (4)20.24 Total impact
- SourceAvailable from: Jörg Hamann
Article: CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism[Show abstract] [Hide abstract]
ABSTRACT: Antibodies to the pan-leukocyte adhesion-GPCR CD97 efficiently block neutrophil recruitment in mice, thereby reducing antibacterial host defense, inflammatory disease, and hematopoietic stem cell mobilization. Here, we investigated the working mechanism of the CD97 antibody 1B2. Applying sterile models of inflammation, intravital microscopy, and mice deficient for the CD97L CD55, the complement component C3, or the FcR common γ-chain, we show that 1B2 acts in vivo independent of ligand-binding interference by depleting PMN granulocytes in bone marrow and blood. Granulocyte depletion with 1B2 involved FcR but not complement activation and was associated with increased serum levels of TNF and other proinflammatory cytokines. Notably, depletion of granulocytes by CD97 antibody required acute inflammation, suggesting a mechanism of conditional, antibody-mediated granulocytopenia.Journal of leukocyte biology 12/2010; 89(3):413-21. DOI:10.1189/jlb.0510280 · 4.99 Impact Factor
Article: CD97 in leukocyte trafficking.[Show abstract] [Hide abstract]
ABSTRACT: CD97 is a member of the EGF-TM7 family of adhesion G protein-coupled receptors (GPCRs) broadly expressed on leukocytes. CD97 interacts with several cellular ligands via its N-terminal epidermal growth factor (EGF)-like domains. To understand the biological function of CD97, monoclonal antibodies (mAbs) specific for individual EGF domains have been applied in a variety of in vivo models in mice, which represent different aspects of innate and adaptive immunity. Targeting CD97 by mAbs inhibited the accumulation of neutrophilic granulocytes at sites of inflammation thereby affecting antibacterial host defense, inflammatory disorders and stem cell mobilization from bone marrow. Interestingly, targeting CD97 did not impact antigen-specific (adaptive response) models such as delayed type hypersensitivity (DTH) or experimental autoimmune encephalomyelitis (EAE). However, collagen-induced arthritis (CIA), a model for rheumatoid arthritis, was significantly ameliorated suggesting therapeutic value of CD97 targeting. CD97-deficient mice are essentially normal at steady state except for a mild granulocytosis, which increases under inflammatory conditions. Comparison of the consequences of antibody treatment and gene targeting implies that CD97 mAbs actively inhibit the innate response presumably at the level of granulocyte or macrophage recruitment to sites of inflammation. Based on the collected data, we propose that the CD97 mAbs either activate CD97-mediated signal transduction via a yet unknown mechanism or act by inducing CD97 internalization, making CD97 unavailable for binding to its ligands and thereby blocking recruitment of neutrophils and possibly macrophages.Advances in Experimental Medicine and Biology 01/2010; 706:128-37. DOI:10.1007/978-1-4419-7913-1_11 · 2.01 Impact Factor
Article: Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2.[Show abstract] [Hide abstract]
ABSTRACT: CD97 is a member of the EGF-TM7 family of adhesion class receptors, with a proposed role in inflammatory cell recruitment. Neutralization of murine CD97 with the anti-mCD97 mAb 1B2 was efficacious in prevention of murine collagen-induced arthritis, a model with features resembling rheumatoid arthritis. Here, the therapeutic potential of neutralizing CD97 in arthritis was studied with emphasis on the 1B2 pharmacokinetics. Mice with established arthritis were treated with anti-mCD97 or anti-TNF-alpha serum. Ab pharmacokinetics and biodistribution were studied in diseased and nondiseased mice using labeled 1B2. The impact of CD97 expression on Ab pharmacokinetics was studied using CD97 knockout mice. Treatment with 1B2 showed an efficacy comparable to anti-TNF-alpha treatment. Pharmacokinetic analysis of 1B2 in wild-type and CD97 knockout mice indicated a dose-dependent Ab clearance, due to specific interaction with CD97. Biodistribution studies showed accumulation of 1B2 in spleen and lung. In vitro studies using murine splenocytes revealed that CD97 when bound to Ab was internalized. Moreover, soluble CD97 was detected in the supernatant, suggesting Ag shedding. Finally, in arthritic mice, higher levels of soluble CD97 were found and 1B2 treatment led to specific targeting of inflamed paws, resulting in a higher clearance rate of 1B2 in arthritic mice than in wild-type mice. In conclusion, our data support a therapeutic value of CD97 neutralization in experimental arthritis. The pharmacokinetic profile of the 1B2 Ab illustrates the complexity of Ab elimination from an organism and stresses the importance of understanding Ag-Ab interactions when developing therapeutic mAbs.The Journal of Immunology 10/2009; 183(6):4127-34. DOI:10.4049/jimmunol.0901253 · 5.36 Impact Factor
Article: Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue[Show abstract] [Hide abstract]
ABSTRACT: Phosphatidylinositol 3-kinase-dependent activation of protein kinase B (PKB) has been observed in rheumatoid arthritis (RA) synovial tissue, and mechanisms that interfere with this process are protective in animal models of arthritis. PKB can regulate cell survival and proliferation via phosphorylation-dependent inactivation of forkhead box class O (FoxO) transcription factors. The present study was undertaken to examine whether FoxO transcription factors are differentially inactivated in RA synovial tissue, and whether this inactivation correlates with laboratory and clinical parameters of disease activity. The expression and phosphorylation of FoxO family members were assessed in synovial biopsy tissue from 12 patients with RA and 9 patients with inflammatory osteoarthritis (OA), by immunohistochemistry and quantitative computer-assisted image analysis. Immunoblotting was used to assess the interleukin-1beta (IL-1beta)- and tumor necrosis factor alpha (TNFalpha)-induced phosphorylation of FoxO1 and FoxO4 in cultured fibroblast-like synoviocytes (FLS) and macrophages. FoxO1, FoxO3a, and FoxO4 were expressed and phosphorylated in synovial tissue from both RA patients and OA patients. In RA synovial tissue, phosphorylation of FoxO1 was observed in both FLS and macrophages, FoxO3a in T lymphocytes, and FoxO4 in macrophages alone. Following stimulation with IL-1beta and TNFalpha, FoxO1 and FoxO4 were phosphorylated in both RA and OA FLS and synovial macrophages, respectively. Inactivation of FoxO4 was significantly enhanced in the RA as compared with the OA synovial sublining. There was a strong negative correlation between inactivation of FoxO4 in RA synovial tissue and increased serum C-reactive protein levels and a raised erythrocyte sedimentation rate in RA patients. All 3 FoxO family members examined were phosphorylated in both RA and OA synovial tissue; in particular, inactivation of FoxO4 was significantly enhanced in macrophages from RA synovial tissue. Thus, cell-specific inactivation of FoxO family members appears to differentially regulate cell survival and proliferation in the RA synovium.Arthritis & Rheumatology 07/2007; 56(7):2180-91. DOI:10.1002/art.22653 · 7.87 Impact Factor
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The Giant Beastcast: Episode 06
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Her Story is a bold and largely successful experiment in interactive crime fiction.
Rocksteady's gorgeous-looking third Arkham game refines its open-world format a bit and lets you drive a whole hell of a lot of Batmobile.
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Released Nov 30, 1999
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Facing Worlds is one of the most memorable Capture The Flag maps of all time.
Phobos is a moon of Mars.
Area above houses and buildings. You can walk, run or jump on and over rooftops. Usually good sniping positions.
Space, the Final Frontier, the focal point and main location of space faring games, from Asteroids to the Mass Effect series.
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Brady girls remain unbeaten
Neither the Paxton Tigers nor the Cody-Kilgore Cowboys presented much of a challenge for the undefeated Brady girls over the weekend.
The Eagles defeated Paxton 53-32 at home on Friday night and hammered Cody-Kilgore 53-21 on the road Saturday.
"Those are difficult games," said Brady coach Lance Arterburn, "especially considering some of the opponents we have ahead of us."
But both contests allowed the Eagles to experiment with some half-court plays and a new press.
Brady opened Friday's game with Paxton on a 15-1 run in the first quarter, finishing the period up 16-7 and then leading 32-17 at halftime.
Arterburn did not deviate from his five-at-a-time substitution as he used every girl in uniform.
Sophomore Josie Palmer scored 18 points to lead Brady with senior Dakota Terry pitching in with 12 points.
A similar situation came about at Cody the next day.
Leading 12-5 at the end of the first quarter, Arterburn said Brady's game at Cody was the first time in his career of coaching that he pulled back the reigns and told the girls not to fast break.
"It was tough on them because that's how they like to play but it did give us a chance to really work on our half-court plays," he said.
After a 27-10 advantage at halftime, the Eagles allowed only 11 Cowboy points in the second half.
Palmer was again the leading scorer with 10 points while Valerie Most offered nine, Terry had eight and Carissa Rayburn chipped in seven.
"We've had pretty good balance in our scoring," Arterburn said.
The Eagles move to 3-0 on the season and will host 4-1 Hitchcock County on Friday.
Arterburn said the Falcons are the only regular-season team he has not earned a victory over as a coach and the only team his group of high school girls has never beaten.
"They won't be holding anything back," Arterburn said of his Eagles.
Tipoff is set for 6 p.m. Friday.
Then Brady will travel to Loomis to face the unbeaten Wolves Saturday.
The Eagles and Wolves will battle for a D2-9 sub-district title later in the season.
"You hate to get beat by a sub-district opponent," Arterburn said. "It will be a big game."
Saturday's start time at Loomis is also 6 p.m.
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text: No recent wiki edits to this page. Robotnik returns? Weren't he & Snively destroyed last issue? Well, unless you missed it you know they downloaded themselves into new bodies. Sonic and the Freedom Fighters are ready to "receive" the fiends but there's an unexpected side effect: Sonic & Tails find they've reversed roles with Robotnik & Snively as they turn mecha and the villains are now human! "Heart to Heart" (by Karl Bollers, Ron Lim, & Pam Eklund): That's exactly what St. John and Hershey have... but can it change decisions they've made that will radically change their lives forever? "Ultimate Power, Part 4" (by Ken Penders & Dawn Best): It's a literal fight to the finish as Knuckles takes on Mammoth Mogul in this climactic battle! Featuring a rollicking cover by Spaz and Ribeiro!


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This Week's Front Page
The sun sets on the horizon, as the Washougal and Fort Vancouver high school football teams play at Fishback Stadium Friday night. The Panthers tore the Trappers to shreds 74-7.
(Photo by Dan Trujillo)
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Hotel Best Roma
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An easy day visiting the Borghese Gallery
... their guests. It was nice to see Romans doing their normal morning routines of running in the park, walking their dogs (including one that looked very much like Cooper), etc.
We met our guide, Massimo, and he introduced us to the gallery. Up until the early 1900s, it was owned by the Borghese family, until they went bankrupt and had to sell the gallery and grounds to the Italian government for around 3.5 million Lira, quite the bargain even back then.
The tour ...
A little step down in Rome
... a square that hosts the ruins of four Roman temples and the remains of Pompey's Theatre. It seemed like everywhere we turned we ran into something of historical significance. Our guide was doing her best to explain the historical background of these ruins to our family, but the kids were far more interested in the many cats that were roaming the ancient site. Figures…!
We continued our walk through the streets of Rome, passed the "Wedding ...
Arrivederci Roma!
... was cooked to perfection. For dessert, we opted to have gelato from a take-out place on the Via Cola di Rienzo, after which I bought a couple pairs of Italian shoes from one of the shops on the way back to the apartment.
I asked Dee and Lucy to write a few paragraphs about their impressions of our stay in Rome, and include them below:
Lucy's Comments: How can I begin to describe the experience of a lifetime ...
A Roman Holiday!!
... away not too impressed with this Aussie of humour! The tour was awe inspiring!! To walk through this ancient building and hear the stories from the tour guide of where people sat,what happened, the amount of animals and people that were killed and to clarify some things in my mind was wonderful! After the Colesum we walked along the original street which was built in the time of Julius Ceaser, and headed to Paletine Hill, which is the ancient Roman city. Words ...
... Then, they had a dance party in the hallway. Free drinks and chips, and they played music through the speakers which was awesome because we were requesting all the songs we loved! At 11, they took pretty much the entire hostel to a Scottish pub in the old part of town. They had a live band playing who was really good. We didn't stay too long since we had 3 more days of exploring Rome.
Saturday it poured all day, and this was the day we walked all over Rome. A ...


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The Asian green mussel is an invasive species to Florida which first began to appear in 1999. This animal can grow to 6" in length and is characterized by its striking green shell. Capable of attaching to any hard substrate by a series of wiry structures known as byssal threads, these animals maybe found on items such as rocks, pilings, seawalls, or even boat propellers.
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FWC Facts:Gulf sturgeon are considered anadromous, from the Greek, meaning fishes that travel back and forth between fresh and salt water.
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Wallace "J." Nichols
- 503 B St, Point Reyes Station, CA, 94956
Eating for the Health of It — Mollie Katzen & Rebecca Katz
Point Reyes Books
Sunday, February 9, 2014 from 12:00 PM to 3:00 PM (PST)
Cookbook authors Rebecca Katz and Mollie Katzen will headline a benefit for The Healing Kitchens Institute to be held at The Fork on the Robert Giacomini Dairy. After learning about the farm, guests will be served a delicious multi-course lunch inspired by the seasonal bounty of West Marin and the recipes of Katzen and Katz—highlighted with a selection of Point Reyes Farmstead cheeses. A conversation on the importance of creating a bridge between cooking and health care follows.
"There's a need for food to be part of the health care and environmental conversation," says Rebecca Katz, a nationally recognized expert on the role of food in supporting health for the chronically ill. She is the author of the cookbook, The Cancer-Fighting Kitchen, and the founder of the Healing Kitchens Institute at Commonweal in Bolinas. The Institute teaches health care providers and interested cooks how to translate nutritional science directly to the plate through taste and flavor. "I translate nutrition into tasty bites of 'yum,'" she explains.
About Rebecca Katz: Rebecca Katz, MS, is the author of The Longevity Kitchen: Satisfying Big-Flavor Recipes Featuring the 16 Top Age-busting Power Foods; the award-winning cookbook, The Cancer Fighting Kitchen: Nourishing Big Flavor Recipes for Cancer and Treatment and Beyond; as well as One Bite at a Time: Nourishing Recipes for Cancer Survivors and Their Friends.
About Mollie Katzen: Mollie Katzen is the author of the Moosewood Cookbook. Her latest book, The Heart Of The Plate: Vegetarian Recipes for a New Generation, is a sparkling repertoire of 250 ultra-flavorful, unfussy vegetarian dishes that exemplify the way Katzen cooks today. An award-winning illustrator and designer as well as a cookbook author for both adults and children, she has been inducted into the James Beard Hall of Fame.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Very nice vintage drink pitcher displaying a red & white gingham design on mid section..measures 8 3/4"high, 4 1/2"wide..in excellent condition with no chips,cracks or discoloration, very clean, the lid fits tight without damage..great for keeping your favorite drink cool..
please contact me with any questions you may have....
please visit my shop again soon as I frequently list new items.
If you were the pending buyer of this item, go to My Account to view, track and check payment for this item.
HUGH Variety of Antiques & Collectibles at Very Reasonable Prices!!
Welcome to Our Shop!! We List Frequently, Inventory is Always Changing So Check Us Out Often!!


text:
- 1 of 123 300H convertibles produced in 1962- 413 CI V-8 engine- Inline dual quad carburetors- Push button A727 TorqueFlite automatic- Chrysler golden... More
- Mopar Best of Show and JW Steiner trophy at Palo Alto Concours- Two year frame-off restoration by Bob Hayen and Gary Goers in... More
This 1957 Chrysler 300C hardtop is a 75k-mile car with an older restoration in excellent condition. Reportedly a special-order car, it is equipped... More
h3>1967 Chrysler Town and Country Wagon When Chrysler created the modern ''Mini Van'' they started a phenomenon in the car industry. But... More
1954 Chrysler New Yorker Deluxe Convertible. Original 4V 235 hp Hemi V8 & Powerflite automatic transmission. Original Kelsey Hayes wire wheels. Exterior has a thin... More
1955 Chrysler Windsor Sedan For Sale or Trade Finished in blue and white, complemented with a blue interior. Famed auto designer Virgil Exner's monumental breakthrough... More
Wonderful 1958 Chrysler Imperial Crown Convertible. Believed to be one of less than 20 existing. Frame off restored in 2013. 392 Hemi 345hp, Carter... More
1959 Chrysler Crown Imperial 2 dr hardtop -- 413 auto -- ran & drove last year original paint except hood -- needs interior redone power windows and seats -- original rims... More
2001 Chrysler Town & Country LX minivan (VIN: 2C4GP44301R335501), dark blue with tan cloth, 250,750 miles, auto trans, 3.3L V6 drives great, power mirrors... More
I ORDERED THIS CAR FOR MY WIFE IN LATE JULY 1989 FROM BUD BROWN CHRYSLER PLYMOUTH IN OVERLAND PARK, KS. THE CAR'S BUILD DATE... More
1969 Chrysler 300, 440 engine w/auto transmission, all original / one owner. The car driven sparingly as a second car, then permantly parked for over... More
1986 Chrysler LeBaron Convertible, AACA Winner with 18,800 orig mi. Immaculate 2.2 litre 4 cyl. Torqueflite auto. FWD . All original dealer paperwork. Runs... More
1967 Chrysler New Port ConvertibleThis model made Chrysler more known for its luxurious vehicles. Therefore this classic car offers plenty of space and comfort.... More
BEAUTIFUL 1967 CHRYSLER NEW YORKER TOWN AND COUNTRY 9 PASSENGER WAGON 383 4 BARREL ENGINE NEW JUST 63000 MILES CALIFORNIA ONE OWNER WAGON THIS... More
Just in! Call or visit our website for more information!... More


text:
[Photo by Olga Berrios via flickr.]
Do you have a favorite blog post about math activities, games, lessons, or hands-on fun? The Math Teachers at Play (MTaP) math education blog carnival would love to feature your article!
We welcome math topics from preschool through the first year of calculus. Old posts are welcome, as long as they haven't been published in past editions of this carnival.
Don't procrastinate: The deadline for entries is Friday, June 19. The carnival will be posted next week at CavMaths.
Would You Like to Host the Carnival?
Hosting the blog carnival is fun because you get to "meet" new bloggers through their submissions. And there's a side-benefit: The carnival often brings a nice little spike in traffic to your blog. If you think you'd like to join in the fun, read the instructions on our Math Teachers at Play page. Then leave a comment or email me to let me know which month you'd like to take.
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text:
picking up shovel shhhhiing
Recorder: DR-40
Knock on vase. Recorded: 11-02-2013. XY-stereo
Knock on vase. Recorded: 11-02-2013. XY-stereo
bleating sheep in a field, recorded from a close distance. Schoeps CMIT 5u/MK8 ->Sound Devices 702t http://www.reuven.nl/sounddesign_postproduction
Several sheep bleating in front of me on the other side of a fence at a distance of about 2 ...
University of North Texas Gamelan Bwana Kumala Ceng-Ceng recording 0. Recorded in 2006.
Sample pack of an Indonesian toy gamelan metallophone recorded with Zoom H1.
pluck wobble
upright choiseul piano multisample recorded using zoom H4n
Door opening and creaking slightly, letting in generator hum from outside
hidden mic recording of someone saying "that makes me so happy!" in the room next to the mic. akg perception ...
Objet sonore créé à partir d'une prise de son de triangle. Sound object made from a triangle. used here : ...
CASA DA MÚSICA's VIRTUAL GAMELAN The Casa da Música's Javanese Gamelan aggregates more than 250 sounds recorded from its various ...
a multisample pack of piano strings played with a finger


text:
Tattoo: when and where?
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seize the day
Senior Member
Join Date: Apr 2013
Posts: 294
S/C/G: 167/re-start:153/ticker/125
Height: 5'4
Novus and Kitcherella, those are awesome tattoo ideas/designs. I like Anais Nin as well. Under a Glass Bell is one of my favorite collections of short stories.
I have 2 tattoos, one on the inside of my ankle (A windmill in a blue delft pattern) and a "Strength for the Living" on my wrist in dutch and Gaelic (To reflect my heritage)
Neither one was too painful IMO. The ankle one was a bit more painful, mainly because it has shading/highlighting and is bigger.
I like tattoos on the upper back, especially shoulder blades, ribs, feet, obviously wrist and inside of the ankle (not as big a fan of the outside of the ankle), tops of the heels (right bellow the achilles tendon, though some places won't do it there), and I love tattoos on calves... but I'm too chicken, and hate my calves too much to have it done.
1. Drink 144 or more oz. of water per day (6 water bottles or more)
2. Keep my net carbs (grams of carbs - grams of fiber) at 60 grams or less per day
3. Keep my sugar content at 25 grams or less per day (primarily from fruit/veggies)
4. Do at least 3 mins of planks every day.
5. Do at least 100 squats every day.
6. Run at least 3 times a week.
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Creating a multisite research assessment and interpretative reporting system leveraging IT can be complicated and expensive. Learn how, with the recent advances in cloud computing and SaaS, UCLA ha…
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- 44What exactly is the creature living in the garbage compactor on the detention level?
- 43How can I give my wife emergency access to logins, passwords, etc.?
- 31Is there a logic behind the naming of the Rebel Alliance's starfighters?
- 10Is it known what the markings mean on Drax The Destroyer's body?
- 10Does Belgium or its inhabitants have any roles of note in DC or Marvel?
- 10What is Thor's armor made of, and where does it originate from?
- 9What does this light shaped like a cylinder mean?
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3993 Howard Hughes ParkwayLas Vegas, NV 89169
Licensed for 21 years
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text: We booked three nights so we could visit Mesa Verde, what a delightful place. A very welcoming atmosphere & unique type of property. After a long day of traveling & arriving late, we were able to relax & enjoy the property before we headed to Mesa Verde. I would stay here again, a home away from home.