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Publications (285)1003.22 Total impact
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Article: Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma[Show abstract] [Hide abstract]
ABSTRACT: Abstract Diisocyanates are the most common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants in inflammatory response genes (TNFα, IL1α, IL1β, IL1RN, IL10, TGFB1, ADAM33, ALOX-5, PTGS1, PTGS2 and NAG-1/GDF15) are associated with increased susceptibility to diisocyanate asthma (DA). These genes were selected based on their role in asthmatic inflammatory processes and previously reported associations with asthma phenotypes. The main study population consisted of 237 Caucasian French Canadians from among a larger sample of 280 diisocyanate-exposed workers in two groups: workers with specific inhalation challenge (SIC) confirmed DA (DA(+), n = 95) and asymptomatic exposed workers (AW, n = 142). Genotyping was performed on genomic DNA, using a 5' nuclease PCR assay. After adjusting for potentially confounding variables of age, smoking status and duration of exposure, the PTGS1 rs5788 and TGFB1 rs1800469 single nucleotide polymorphisms (SNP) showed a protective effect under a dominant model (OR = 0.38; 95% CI = 0.17, 0.89 and OR = 0.38; 95% CI = 0.18, 0.74, respectively) while the TNFα rs1800629 SNP was associated with an increased risk of DA (OR = 2.08; 95% CI = 1.03, 4.17). Additionally, the PTGS2 rs20417 variant showed an association with increased risk of DA in a recessive genetic model (OR = 6.40; 95% CI = 1.06, 38.75). These results suggest that genetic variations in TNFα, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility.Journal of Immunotoxicology 02/2015; DOI:10.3109/1547691X.2015.1017061 · 1.91 Impact Factor
Article: Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma[Show abstract] [Hide abstract]
ABSTRACT: To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA). The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels. The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively). These results suggest that genetic variations within HLA genes play a role in DA risk.Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 04/2014; 56(4):382-7. DOI:10.1097/JOM.0000000000000138 · 1.80 Impact Factor
Article: Influenza vaccine response in adults exposed to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS).[Show abstract] [Hide abstract]
ABSTRACT: Supported by several epidemiological studies and a large number of animal studies, certain polyfluorinated alkyl acids (PFAAs) are believed to be immunotoxic, affecting particularly humoral immunity. Our aim was to investigate the relationship between the antibody response following vaccination with an inactivated trivalent influenza vaccine and circulating levels of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS). The study population consisted of 411 adults living in the mid-Ohio region of Ohio and West Virginia where public drinking water had been inadvertently contaminated with PFOA. They participated in a larger cross-sectional study in 2005/6, and were followed up in 2010, by which time serum levels of PFOA had been substantially reduced but were still well above those found in the general population. Hemagglutination inhibition (HI) tests were conducted on serum samples collected pre-influenza vaccination and 21+/- 3 days post-vaccination in 2010. Serum samples were also analyzed for PFOA and PFOS concentrations (median, 31.5 and 9.2 ng/ml respectively). Questionnaires were conducted regarding the occurrence and frequency of recent (during the last 12 months) respiratory infections. Our findings indicated that elevated PFOA serum concentrations are associated with reduced antibody titer rise, particularly to A/H3N2 influenza virus, and an increased risk of not attaining the antibody threshold considered to offer long term protection. Whilst the direct relationship between weakened antibody response and clinical risk of influenza is not clear, we did not find evidence for an association between self-reported colds or influenza and PFOA levels nor between PFOS serum concentrations and any of the endpoints examined.Toxicological Sciences 11/2013; DOI:10.1093/toxsci/kft269 · 4.48 Impact Factor
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ABSTRACT: Abstract An historical perspective of immunotoxicology is presented beginning from early observations in which exposure to workplace environments led to unexpected immune-mediated lung diseases to its eventual evolution as a sub-discipline in toxicology. As with most toxicology disciplines, immunotoxicology originated from concerns by scientists within industry and government as well as medical professionals to limit human exposure to agents that can potentially effect human health. The basis for these concerns originated from laboratory studies in experimental models and clinical observations that suggested certain industrial and agrochemicals, pharmaceuticals and consumer products were capable of inadvertently interacting with the immune system and cause adverse health effects. The types of immunopathologies observed and mechanisms responsible were found to be broad, being dependent upon the physiochemical properties of an agent, exposure route, and target organ/tissue, and included allergic/hypersensitivity responses, immune dysfunction, manifested by suppression or, in rare instances, stimulation, autoimmune or autoimmune-like diseases, and chronic inflammatory disorders.Journal of Immunotoxicology 10/2013; 11(3). DOI:10.3109/1547691X.2013.837121 · 1.91 Impact Factor
Article: Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations[Show abstract] [Hide abstract]
ABSTRACT: The influence of genetic variability within the major histocompatibility complex (MHC) region on variations in immune responses to childhood vaccination was investigated. The study group consisted of 135 healthy infants who had been immunized with hepatitis B (HBV), 7-valent pneumococcal conjugate (PCV7), and diphtheria, tetanus, acellular pertussis (DTaP) vaccines according to standard childhood immunization schedules. Genotype analysis was performed on genomic DNA using Illumina Goldengate MHC panels (Mapping and Exon Centric). At the 1 year post vaccination check-up total, isotypic, and antigen-specific serum antibody levels were measured using multiplex immunoassays. A number of single nucleotide polymorphisms (SNPs) within MHC Class I and II genes were found to be associated with variations in the vaccine specific antibody responses and serum levels of immunoglobulins (IgG, IgM) and IgG isotypes (IgG1, IgG4) (all at p<0.001). Linkage disequilibrium patterns and functional annotations showed that significant SNPs were strongly correlated with other functional regulatory SNPs. These SNPs were found to regulate the expression of a group of genes involved in antigen processing and presentation including HLA-A, HLA-C, HLA-G, HLA-H, HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-DQA1, HLA-DQB1, HLA-DOB, and TAP-2. The results suggest that genetic variations within particular MHC genes can influence immune response to common childhood vaccinations, which in turn may influence vaccine efficacy.Vaccine 09/2013; 31(46). DOI:10.1016/j.vaccine.2013.09.026 · 3.49 Impact Factor
Article: Winter Season, Frequent Hand Washing, and Irritant Patch Test Reactions to Detergents Are Associated With Hand Dermatitis in Health Care Workers[Show abstract] [Hide abstract]
ABSTRACT: Irritant hand dermatitis (IHD) is common in health care workers. We studied endogenous irritant contact dermatitis threshold by patch testing and exogenous factors such as season and hand washing for their association with IHD in health care workers. Irritant patch testing with sodium lauryl sulfate (SLS), sodium hydroxide, and benzalkonium chloride at varying concentrations was measured in 113 health care workers. Examination for hand dermatitis occurred at 1-month intervals for a period of 6 months in the Midwestern United States. Positive patch testing to low-concentration SLS was associated with IHD (P = 0.0310) after adjusting for age, sex, ethnicity, season, history of childhood flexural dermatitis, mean indoor relative humidity, and glove and hand sanitizer usage. Subjects with a positive patch test to SLS were 78% more likely to have occurrence of IHD (incidence rate ratio [IRR] = 1.78; 95% confidence interval [CI], 0.92-3.45). Hand washing frequency (≥10 times a day; IRR = 1.55; 95% CI, 1.01-2.39) and cold season (IRR = 2.76; 95% CI, 1.35-5.65) were associated with IHD. No association was found between history of childhood flexural dermatitis and IHD in this population. Both genetic and environmental factors are important in the etiology of IHD and should be considered in designing strategies to protect, educate, and treat susceptible individuals.Dermatitis 07/2013; 24(4):170-5. DOI:10.1097/DER.0b013e318290c57f · 1.36 Impact Factor
Article: Reductions in Serum Lipids with a 4-year Decline in Serum Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND:: Several epidemiological cross-sectional studies have found positive associations between serum concentrations of lipids and perfluorooctanoic acid (PFOA, or C8). A longitudinal study should be less susceptible to biases from uncontrolled confounding or reverse causality. METHODS:: We investigated the association between within-individual changes in serum PFOA and perfluorooctanesulfonic acid (PFOS) and changes in serum lipid levels (low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol, total cholesterol, and triglycerides) over a 4.4-year period. The study population consisted of 560 adults living in parts of Ohio and West Virginia where public drinking water had been contaminated with PFOA. They had participated in a cross-sectional study in 2005-2006, and were followed up in 2010, by which time exposure to PFOA had been substantially reduced. RESULTS:: Overall serum concentrations of PFOA and PFOS fell by half from initial geometric means of 74.8 and 18.5 ng/mL, respectively, with little corresponding change in LDL cholesterol (mean increase 1.8%, standard deviation 26.6%). However, there was a tendency for people with greater declines in serum PFOA or PFOS to have greater LDL decrease. For a person whose serum PFOA fell by half, the predicted fall in LDL cholesterol was 3.6% (95% confidence interval = 1.5-5.7%). The association with a decline in PFOS was even stronger, with a 5% decrease in LDL (2.5-7.4%). CONCLUSIONS:: Our findings from this longitudinal study support previous evidence from cross-sectional studies of positive associations between PFOA and PFOS in serum and LDL cholesterol.Epidemiology (Cambridge, Mass.) 05/2013; 24(4). DOI:10.1097/EDE.0b013e31829443ee · 6.18 Impact Factor
Article: Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans.[Show abstract] [Hide abstract]
ABSTRACT: Perfluorooctanoic acid (PFOA, 'C8') and perfluoroctane sulphonate (PFOS) are environmentally stable compounds with industrial and consumer uses and long half-lives in humans. Concern has been raised over chronic exposure effects to human health, especially in relation to cholesterol metabolism. Here, we explore the association between exposure to PFOA and PFOS and the in vivo expression of genes involved in cholesterol metabolism. We studied 290 individuals exposed to background levels of PFOS and elevated concentrations of PFOA through drinking water. Using adjusted linear regression models, we found inverse associations between serum PFOA levels and the whole blood expression level of genes involved in cholesterol transport (NR1H2, NPC1 and ABCG1; p=0.002, 0.026 and 0.014 respectively). A positive association was seen between PFOS and a transcript involved in cholesterol mobilisation (NCEH1; p=0.018), and a negative relationship with a transcript involved in cholesterol transport (NR1H3; p=0.044). When sexes were analysed separately, reductions in the levels of mRNAs involved in cholesterol transport were seen with PFOA in men (NPC1, ABCG1, and PPARA; p=0.025, 0.024 and 0.012 respectively) and in women (NR1H2 expression; p=0.019), whereas an increase in the levels of a cholesterol mobilisation transcript (NCEH1; p=0.036) was noted in women alone. PFOS was positively associated with expression of genes involved in both cholesterol mobilisation and transport in women (NCEH1 and PPARA; p=0.003 and 0.039 respectively), but no effects were evident in men. This is the first report of associations between the in vivo expression of genes involved in cholesterol metabolism and exposure to PFOA or PFOS, suggested that exposure to these compounds may promote a hypercholesterolaemic environment, with wider implications for human disease.Environment international 04/2013; 57-58C:2-10. DOI:10.1016/j.envint.2013.03.008 · 5.66 Impact Factor
Article: CTNNA3 (alpha-Catenin) Gene Variants Are Associated With Diisocyanate Asthma: A Replication Study in a Caucasian Worker Population[Show abstract] [Hide abstract]
ABSTRACT: Recently, a genome wide association study (GWAS) conducted in Korean subjects identified three CTNNA3 (alpha-T catenin) single nucleotide polymorphisms (SNPs) (rs10762058, rs7088181, and rs4378283) associated with diisocyanate induced occupational asthma (DA). The CTNNA3 gene codes for a cadherin involved in formation of stretch-resistant cell-cell adhesions. We conducted a candidate gene association study to replicate these findings in Caucasian workers. Genotyping was performed on DNA using a 5' nuclease PCR assay collected from 410 diisocyanate exposed and predominantly Canadian workers including: 132 workers with DA confirmed by a specific inhalation challenge (DA+); 131 symptomatic workers in whom DA was excluded by a negative challenge (DA-); and 147 HDI-exposed asymptomatic workers (AWs). As in the Korean study, highly linked CTNNA3 rs7088181 and rs10762058 SNPs were significantly associated with DA+ when compared to AWs but not in comparison to DA- workers (p≤ 0.05). After adjusting for potentially confounding variables of age, smoking status and duration of exposure, minor allele homozygotes of rs7088181 and rs10762058 SNPs were at increased risk for DA compared with AWs [OR= 9.05 (95% CI:1.69, 48.54) and OR = 6.82 (95% CI:1.65, 28.24), respectively]. In conclusion, we replicated results from the only reported GWAS study of DA demonstrating an association between two closely linked CTNNA3 gene SNPs and DA. These findings lend further support to the clinical relevance of these genotypes in predicting susceptibility to DA and the potential importance of cadherins in the disease process.Toxicological Sciences 09/2012; 131(1). DOI:10.1093/toxsci/kfs272 · 4.48 Impact Factor
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ABSTRACT: Diisocyanates are a common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants of antioxidant defense genes, glutathione S-transferases (GSTM1, GSTT1, GSTM3, GSTP1), manganese superoxide dismutase (SOD2), and microsomal epoxide hydrolase (EPHX1) are associated with increased susceptibility to diisocyanate-induced asthma (DA). The main study population consisted of 353 Caucasian French-Canadians from among a larger sample of 410 diisocyanate-exposed workers in three groups: workers with specific inhalation challenge (SIC) confirmed DA (DA(+), n = 95); symptomatic diisocyanate workers with a negative SIC (DA(-), n = 116); and asymptomatic exposed workers (AW, n = 142). Genotyping was performed on genomic DNA, using a 5'-nuclease PCR assay. The SOD2 rs4880, GSTP1 rs1695, and EPHX1 rs2740171 variants were significantly associated with DA in both univariate and multivariate analyses. In the first logistic regression model comparing DA(+) and DA(-) groups, SOD2 rs4880, GSTM1 (null), GSTP1 rs762803, and EPHX1 rs2854450 variants were associated with DA (p = 0.004, p = 0.047, p = 0.021, p <0.001, respectively). Genotype combinations GSTT1*GSTP1 rs762803, GSTM1*EPHX1 rs2854450, EPHX1 rs2740168*EPHX1 rs1051741, and GSTP1 rs762803*EPHX1 rs2740168 were also associated with DA in this model (p = 0.027, p = 0.002, p = 0.045, p = 0.044, respectively). The GSTP1 rs1695 and EPHX1 rs1051741 and rs2740171 variants showed an association with DA in the second model comparing DA(+) and AW groups (p = 0.040, p = 0.019, p = 0.002, respectively). The GSTM3 rs110913*EPHX1 rs1051741 genotype combination was also associated with DA under this model (p = 0.042). The results suggest that variations in SOD2, GST, and EPHX1 genes and their interactions contribute to DA susceptibility.Toxicological Sciences 05/2012; 129(1):166-73. DOI:10.1093/toxsci/kfs183 · 4.48 Impact Factor
Article: Association of osteoarthritis with serum levels of the environmental contaminants perfluorooctanoate and perfluorooctane sulfonate in a large Appalachian population.[Show abstract] [Hide abstract]
ABSTRACT: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent environmental contaminants that affect metabolic regulation, inflammation, and other factors implicated in the pathogenesis of osteoarthritis (OA). However, the link between these compounds and OA remains unknown. In this study, the authors investigated the association of OA with PFOA and PFOS in a population of 49,432 adults from 6 PFOA-contaminated water districts in the mid-Ohio Valley (2005-2006). Participants completed a comprehensive health survey; serum levels of PFOA, PFOS, and a range of other blood markers were also measured. Medical history, including physician diagnosis of osteoarthritis, was assessed via self-report. Analyses included adjustment for demographic and lifestyle characteristics, body mass index, and other potential confounders. Reported OA showed a significant positive association with PFOA serum levels (for highest quartile of PFOA vs. lowest, adjusted odds ratio = 1.3, 95% confidence interval: 1.2, 1.5; P-trend = 0.00001) and a significant inverse association with PFOS (for highest quartile vs. lowest, adjusted odds ratio = 0.8, 95% confidence interval: 0.7, 0.9; P-trend = 0.00005). The relation between PFOA and OA was significantly stronger in younger and nonobese adults. Although the cross-sectional nature of this large, population-based study limits causal inference, the observed strong, divergent associations of reported OA with PFOA and PFOS may have important public health and etiologic implications and warrant further investigation.American journal of epidemiology 06/2011; 174(4):440-50. DOI:10.1093/aje/kwr107 · 4.98 Impact Factor
Article: Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor α.The Journal of allergy and clinical immunology 04/2011; 128(2):418-20. DOI:10.1016/j.jaci.2011.03.007 · 11.25 Impact Factor
- Journal of Allergy and Clinical Immunology 02/2010; 125(2). DOI:10.1016/j.jaci.2010.01.013 · 11.25 Impact Factor
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ABSTRACT: The magnitude of the immune response to vaccinations can be influenced by genetic variability. In the present study, we aimed to investigate whether cytokine or cytokine receptor gene polymorphisms were associated with variations in the immune response to childhood vaccination. The study group consisted of 141 healthy infants who had been immunized with hepatitis B vaccine (HBV), 7-valent pneumococcal conjugate (PCV7), and diphtheria, tetanus, acellular pertussis (DTaP) vaccines according to standard childhood immunization schedules. Genotype analysis was performed on genomic DNA using a 5' nuclease PCR assay. Post vaccination total, isotypic, and antigen-specific serum antibody levels were measured using multiplex immunoassays. Significant associations were observed between SNPs in the TNFalpha, IL-12B, IL-4Ralpha, and IL-10 genes and vaccine-specific immune responses (p<0.05). In addition, SNPs in the IL-1beta, TNFalpha, IL-2, IL-4, IL-10, IL-4Ralpha, and IL-12B genes were associated with variations in serum levels of immunoglobulins (IgG, IgA, IgM) and IgG isotypes (IgG1-IgG3) (p<0.05). These data suggest that genetic variations in cytokine genes can influence vaccine-induced immune responses in infants, which in turn may influence vaccine efficacy.Vaccine 10/2009; 27(50):6991-7. DOI:10.1016/j.vaccine.2009.09.076 · 3.49 Impact Factor
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ABSTRACT: The purpose of this study was to investigate whether the expression of specific genes in peripheral blood can be used as surrogate marker(s) to detect and distinguish target organ toxicity induced by chemicals in rats. Rats were intraperitoneally administered a single, acute dose of a well-established hepatotoxic (acetaminophen) or a neurotoxic (methyl parathion) chemical. Administration of acetaminophen (AP) in the rats resulted in hepatotoxicity as evidenced from elevated blood transaminase activities. Similarly, administration of methyl parathion (MP) resulted in neurotoxicity in the rats as evidenced from the inhibition of acetyl cholinesterase activity in their blood. Administration of either chemical also resulted in mild hematotoxicity in the rats. Microarray analysis of the global gene expression profile of rat blood identified distinct gene expression markers capable of detecting and distinguishing hepatotoxicity and neurotoxicity induced by AP and MP, respectively. Differential expressions of the marker genes for hepatotoxicity and neurotoxicity were detectable in the blood earlier than the appearance of the commonly used clinical markers (serum transaminases and acetyl cholinesterase). The ability of the marker genes to detect hepatotoxicity and neurotoxicity was further confirmed using the blood samples of rats administered additional hepatotoxic (thioacetamide, dimethylnitrobenzene, and carbon tetrachloride) or neurotoxic (ethyl parathion and malathion) chemicals. In summary, our results demonstrated that blood gene expression markers can detect and distinguish target organ toxicity non-invasively.Molecular and Cellular Biochemistry 09/2009; 335(1-2):223-34. DOI:10.1007/s11010-009-0272-5 · 2.39 Impact Factor
Article: Meeting Report: Moving Upstream—Evaluating Adverse Upstream End Points for Improved Risk Assessment and Decision-Making[Show abstract] [Hide abstract]
ABSTRACT: Assessing adverse effects from environmental chemical exposure is integral to public health policies. Toxicology assays identifying early biological changes from chemical exposure are increasing our ability to evaluate links between early biological disturbances and subsequent overt downstream effects. A workshop was held to consider how the resulting data inform consideration of an "adverse effect" in the context of hazard identification and risk assessment. Our objective here is to review what is known about the relationships between chemical exposure, early biological effects (upstream events), and later overt effects (downstream events) through three case studies (thyroid hormone disruption, antiandrogen effects, immune system disruption) and to consider how to evaluate hazard and risk when early biological effect data are available. Each case study presents data on the toxicity pathways linking early biological perturbations with downstream overt effects. Case studies also emphasize several factors that can influence risk of overt disease as a result from early biological perturbations, including background chemical exposures, underlying individual biological processes, and disease susceptibility. Certain effects resulting from exposure during periods of sensitivity may be irreversible. A chemical can act through multiple modes of action, resulting in similar or different overt effects. For certain classes of early perturbations, sufficient information on the disease process is known, so hazard and quantitative risk assessment can proceed using information on upstream biological perturbations. Upstream data will support improved approaches for considering developmental stage, background exposures, disease status, and other factors important to assessing hazard and risk for the whole population.Environmental Health Perspectives 12/2008; 116(11):1568-75. DOI:10.1289/ehp.11516 · 7.03 Impact Factor
Article: Immunotoxicity of Perfluorooctanoic Acid and Perfluorooctane Sulfonate and the Role of Peroxisome Proliferator-Activated Receptor Alpha[Show abstract] [Hide abstract]
ABSTRACT: Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are environmentally widespread and persistent chemicals with multiple toxicities reported in experimental animals and humans. These compounds can trigger biological activity by activating the alpha isotype of peroxisome proliferator-activated receptors (PPARs), ligand-activated transcription factors that regulate gene expression; however, some biological effects may occur independently of the receptor. Activation of the peroxisome proliferator-activated receptor alpha (PPARalpha) modulates lipid and glucose homeostasis, cell proliferation and differentiation, and inflammation. Reported immunomodulation in experimental animals exposed to PFOA and PFOS has included altered inflammatory responses, production of cytokines and other proteins, reduced lymphoid organ weights, and altered antibody synthesis. Mounting experimental animal evidence suggests PPARalpha independence of some immune effects. This evidence originates primarily from studies with PPARalpha knockout models exposed to PFOA that demonstrate hepatic peroxisome proliferation, reduced lymphoid organ weights, and altered antibody synthesis. As human PPARalpha expression is significantly less than that of rodents, potential PPARalpha independence indicates that future research must explore mechanisms of action of these compounds, including PPARalpha-dependent and -independent pathways. This multiauthored review contains brief descriptions of current and recently published work exploring immunomodulation by PFOA and PFOS, as well as a short overview of other PPARalpha ligands of therapeutic and environmental interest.Critical Reviews in Toxicology 10/2008; 39(1):76-94. DOI:10.1080/10408440802209804 · 6.41 Impact Factor
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ABSTRACT: Abstract Short-term inhalation studies were conducted to evaluate the potential effects of styrene on the immune system. Female B6C3F1 mice were exposed by inhalation to 0, 125, 250, or 500 ppm styrene, 6 h/day for 14 consecutive days. Thymus and spleen weights in styrene-exposed mice were decreased in the high-dose animals, and a marked decrease in spleen cellularity occurred in all chemically treated groups. Cytometric analysis of spleen cells revealed a slight increase in the percentage of B cells and a decrease in the absolute number of CD4′ cells. This latter change was responsible for a shift in the CD4/CD8 ratio observed in the high dose group. Corresponding increases in the prolifer-ative response to the B-lymphocyte mitogen lipopolysaccharide as well as an increase in the primary antibody response to sheep erythrocytes were observed. Cell-mediated immunity was unaffected by styrene inhalation as demonstrated by normal cytotoxic T-lympho-cyte and mixed leukocyte responses. Changes in spleen cellularity were not reflected at the level of the stem cell, as bone marrow cellularity was unaffected by styrene treatment. Styrene slightly suppressed spleen natural killer (NK) cell activity without affecting lung NK cell activity. These studies indicate that the primary immune effect of styrene is splenic hypocellularity. Although an imbalance in the B and T spleen lymphocyte sub-populations and a decrease in spleen NK cell activity were observed, the magnitudes of these effects were minimal.Inhalation Toxicology 09/2008; 6(6):647-654. DOI:10.3109/08958379409003045 · 2.34 Impact Factor
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ABSTRACT: Progressive massive fibrosis (PMF) is a chronic interstitial lung disease with a complex aetiology that can occur after cumulative dust exposure. A case-control study was conducted to test the hypothesis that single nucleotide polymorphisms (SNPs) within genes involved in inflammatory and fibrotic processes modulate the risk of PMF development. The study population consisted of 648 underground coal miners participating in the National Coal Workers Autopsy Study, of which 304 were diagnosed with PMF. SNPs that influence the regulation of interleukin (IL)-1, IL-6, tumour necrosis factor-alpha, transforming growth factor-beta1, vascular endothelial growth factor (VEGF), epidermal growth factor intercellular cell adhesion molecule (ICAM)-1 and matrix metalloproteinase-2 genes were determined using a 5'-nuclease real-time PCR assay. There were no significant differences in the distribution of any individual SNP or haplotype between the PMF and control groups. However, the polygenotype of VEGF +405/ICAM-1 +241/IL-6 -174 (C-A-G) conferred an increased risk for PMF (odds ratio 3.4, 95% confidence interval 1.3-8.8). The present study suggests that the examined genetic variations that help regulate inflammatory and fibrotic processes are unlikely to strongly influence susceptibility to this interstitial lung disease, although the role of vascular endothelial growth factor, intercellular cell adhesion molecule-1 and interleukin-6 polymorphisms in the development of progressive massive fibrosis may require further investigation.European Respiratory Journal 07/2008; 31(6):1177-82. DOI:10.1183/09031936.00075107 · 7.13 Impact Factor
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ABSTRACT: To investigate whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in forced expiratory volume in 1 second (FEV1). Functional polymorphisms in the TNFalpha, TGF beta 1, IL-1 beta, IL-1RN, IL-13, and IL-8 genes were investigated in 374 active firefighters with at least five pulmonary function tests. A protective effect was found between the presence of the TGF beta 1 -509 TT genotype and rate of decline in FEV1 (P = 0.043). Carrying an A allele at TNFalpha -308 (P = 0.010) and GG genotype at TNFalpha -238 (P = 0.028) was associated with a more rapid rate of FEV1 decline. The TNFalpha -308A/-238G haplotype was also associated with an increased rate of decline as compared with the other haplotypes. Interindividual variability in progressive decline in FEV1 may be explained in part by genetic variations within genes involved in inflammatory responses.Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 07/2008; 50(6):642-8. DOI:10.1097/JOM.0b013e31816515e1 · 1.80 Impact Factor
Top Journals
West Virginia University
MGW, West Virginia, United States
- • Department of Community Medicine
- • Department of Medicine
East Carolina UniversityNorth Carolina, United States
National Institute of Environmental Health SciencesDurham, North Carolina, United States
Molecular Toxicology, Inc.North Carolina, United States
Centers for Disease Control and Prevention
Druid Hills, GA, United States
- • Agency for Toxic Substances and Disease Registry
- • Health Effects Laboratory Division
Ankara University
Ankara, Ankara, Turkey
- Faculty of Pharmacy
ILSI Health and Environmental Sciences InstituteWashington, Washington, D.C., United States
Honolulu UniversityHonolulu, Hawaii, United States
Georgia State University
Atlanta, GA, United States
- Division of Physical Therapy
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
- Department of Environmental and Occupational Health
Northern Inyo HospitalBIH, California, United States
University of North Carolina at Chapel Hill
Chapel Hill, NC, United States
- Department of Pharmacology
National Institutes of Health
Maryland, United States
- Branch of Occupational and Environmental Epidemiology
Tokai UniversityHiratuka, Kanagawa, Japan
University of Michigan
Ann Arbor, Michigan, United States
- Department of Dermatology
Virginia Polytechnic Institute and State University
Blacksburg, VA, United States
- Department of Biomedical Sciences and Pathobiology
University of MilanMilano, Lombardy, Italy
University of Louisiana at Monroe
Монро, Louisiana, United States
- Department of Biology
North Carolina State UniversityRaleigh, North Carolina, United States
Virginia Commonwealth University
Ричмонд, Virginia, United States
- Department of Pharmacology and Toxicology


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THR's Midseason TV Report Card: Where the Networks Stand Heading Into TCA
NBC prays for a "Smash" and the other broadcast nets arrive with a sense of (cautious) optimism.
Where It Stands: Greenblatt has yet to put his stamp on the fourth-place network, and the only Nielsen feat worth touting in recent months was the strong debut of Fear Factor, a reality revival from the Jeff Zucker era. (It plummeted in week two.) Worse, the network is heading into the spring without its only top-30 series: Sunday Night Football. But NBC is hoping for big numbers out of last spring's breakout The Voice, which will premiere after the Super Bowl before moving to Monday as a lead-in for Greenblatt's pet project Smash, a big bet for the network. "It's the type of show that could become a huge hit or go down in flames," Horizon's Adgate says of the Spielberg-produced musical drama, adding,"It could be Lone Star or it could be Glee."
What it Needs: Ratings, plain and simple. NBC has high hopes for the John Grisham adaptation The Firm, which will run repeat-free for 22 episodes on Thursdays at 10 p.m. "In previous years, we've loaded up our fall with every piece that we had," acknowledges Lisa Vebber, NBC's senior vp scheduling and programming. "I'm proud of the fact that this year we've exercised some patience and are focused on the longer-term play." Its viewers-challenged 10 p.m. hour and once-must-see-TV comedy block on Thursday remain big questions, with 30 Rock subbing for Community. Expectations are even lower for NBC's female-skewing Wednesday block, where Whitney will be paired with the Chelsea Handler sitcom Are You There, Chelsea? in an attempt to cement a comedy foothold on a second night.
What to Look For: Expect hefty Super Bowl promotion for Voice and Smash. But don't get too attached to NBC's Wednesday lineup, which houses a mishmash of comedies (Whitney and Chelsea), a news-magazine (Rock Center in the uber-competitive 9 p.m. slot opposite ABC's Modern Family and Fox's American Idol) and an aging procedural (Law & Order: SVU). And don't forget The Donald. Trump's Celebrity Apprentice will no doubt draw buzz with Lisa Lampanelli, Clay Aiken and a Real Housewife (Teresa Giudice). Greenblatt hopes it draws viewers, too.
- 2 Broke Girls (CBS): 13.6 million
- Unofrgettable (CBS): 13.5 million
TOP FIVE SHOWS OF THE FALL: Two and Half Men has boosted Girls
- 2 Broke Girls (CBS): 5.4 rating
- New Girl (Fox): 5.0
- The X Factor -- Wed. (Fox): 4.3
- The X Factor -- Thurs. (Fox): 4.1
- Once Upon A Time (ABC): 4.1
- CBS: 18-49 rating: 3.3 (+3%) | Total viewers: 12.5 million (+1%)
- FOX: 3.3 (+14%) | 9.0 million (+15%)
- ABC: 2.6 (-4%) | 9.1 million (-1%)
- NBC: 2.5 (-11%) | 7.3 million (-11%)
18-49 demo. Source: Nielsen, most-current data Sept. 19-Dec. 19
Never miss a story. Stay up-to-date with THR's Daily Headlines.
Must Reads
Comic-Con: Which Movies Could Benefit From Panel Buzz?
Comic-Con 2015: THR's Full Guide to Parties in San Diego
CBS Entertainment Chief and "Loudmouthed Feminist" Nina Tassler Reveals the Strategy Behind 'Supergirl' Gamble
Paul Rudd and Marvel's Kevin Feige Reveal 'Ant-Man's' Saga, from Director Shuffle to Screenplay Surgery to Studio's "Phase Three" Plans
HBO's Real-Life Game of Thrones: The Fight to Stay Rich, on Top and Score Bill Simmons
Taraji P. Henson, Viola Davis and Drama Actress A-List Tackle Race, Sexism, Aging in Hollywood
Lena Dunham, Amy Schumer and Comedy Actress A-List in Raunchy, R-Rated Roundtable
Bob Odenkirk, David Oyelowo and Drama Actor A-List on Oscar Snubs, Bad Scripts and Getting Ignored by Robert Redford

subset: commoncrawl


text: Betfair Arcade £5 Free Bet Offer BingoBonkers Staff in Games 5 Oct 2011 0 Share Share Tweet +1 EmailShare Betfair Arcade is giving away a £5 Free Bet to all new players who join and wager £5 on any Arcade games.To qualify, you must wager a minimum of £5 on Deal or No Deal or Deal or No Deal – International on Betfair Arcade during until 31st October and in turn, Betfair Arcade will award all qualifiers with a £5 Free Bet. Enter the Betfair promo code OCTDOND when you Opt In to the promotion and claim your Free Bet.The Free Bets will be applied every Friday until 31st October. For instance, if you play on Betfair Arcade for the first time on the 4th October, you will be credited with your £5 Free Bet on Saturday, 8th October. Those of you who meet these requirements on a Friday will be credited the following week. The Free Bet is valid for 7 days. If you do not use your Free Bets within this timeframe, the Free Bet will be lost.


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San Francisco parking app refuses shut-down order
San Francisco • The company behind an app that allows San Francisco drivers to get paid for the public parking spaces they exit is rejecting an order from the city attorney to stop its operations.
MonkeyParking CEO Paolo Dobrowolny said Friday that City Attorney Dennis Herrera is misapplying a police code that prohibits the sale or lease of San Francisco's streets.
Dobrowolny says MonkeyParking doesn't sell parking spots, but convenience. He cites freedom of speech, saying people have the right to tell others they're leaving a parking spot and get paid for it.
Herrera sent a letter to the Italy-based company Monday saying city code prevents the sale or lease of city streets.
Herrera spokesman Matt Dorsey says in a statement that Dobrowolny is making an argument akin to a prostitute saying she isn't selling sex, just information about her willingness to have sex.


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This Week's Front Page
High roller Sky Masterson (James Maguire, foreground) and other gamblers contemplate their next floating dice game.
(Photo by Danielle Frost)
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Available in Light Pink
Nothing says feminine like rose-patterned lace, which is why we love this beautiful sleeveless top so much. Its sheer back provides the perfect opportunity to show off a pretty cami or bralette, and contrast detailing along the sides adds an eye-catching touch. Our take: we're highlighting its round neckline with some charm necklaces for a super sweet look. Lightweight, wovenPartially linedShell 1: 91% nylon, 9% spandex; Shell 2: 100% polyester; Lining: 100% polyester20.5" full length, ...
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Love 21 - Shaggy and ultra-soft? We're all in! This fuzzy knit top is complete with short sleeves that are ideal for layering under a denim jacket for some edge. Our recommendation? Accentuate the round neckline with a dainty charm necklace for a subtly girly touch. Lightweight75% nylon, 25% acrylic19" full length, 28" chest, 28" waist, 14" sleeve lengthMeasured from SmallHand wash coldImported
Available in Black, Light Aqua, Pink, Rust
A lace top featuring sheer long sleeves. Round neckline. Exposed back zipper. Partially lined. Knit. Lightweight. DETAILS:20" approx. length from high point shoulder to hem, 28" chest, 28" waist, 26" sleeve length from high point shoulderMeasured from SmallShell: 93% nylon, 7% spandex Lining:100% rayonHand wash cold, dry flatImported
Forever 21+ - Embrace flirty and femme vibes in this sleeveless lace top, complete with chiffon panels, a round neckline, and an exposed back zipper. We love it paired with a quilted leather pencil skirt and pumps to toughen it up for nighttime. Lightweight, unlinedKnitShell: 91% nylon, 9% spandex; Contrast: 100% polyester23" full length, 36" chest, 36" waistMeasured from 1XHand wash coldImported
Available in Black, Cream, Light Pink
With this long-sleeved blouse in your closet, your days of having nothing to wear are over! The front features a beautiful floral lace overlay, lending it a subtle feminine touch. We also love how wide round neckline allows you to show off all your favorite statement necklaces. Knit, partially linedLightweightShell: 53% rayon, 47% polyester; Shell 2: 92% nylon, 8% spandex23" full length, 36" chest, 39" waist, 26" sleeve lengthMeasured from SmallHand wash coldImported
Available in Light Blue/White, Peach/Light Pink
Lounge around the house (and possibly fall asleep) in this comfy cami! Its padded bust lends just enough support and its stripe print keeps this feeling fun and fresh. Adjustable straps, partially linedStretch knitShell: 64% nylon, 30% polyester, 6% spandex; Lining: 100% polyesterMachine wash coldMade in China
Available in Beige, Black, Hunter Green, ...
"Wardrobe essential" is an understatement when it comes to this classic knit cami! Perfect for layering for warmth or adding coverage to sheer pieces, this must-have will make constant appearances in your daily wardrobe rotation. Adjustable StrapsLightweight92% nylon, 8% spandex19" bust to hem, 25" chest, 25" waistMeasured from SmallMachine wash coldImported


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NCR Staff
News Articles
Articles by NCR Staff
Activists, religious dignitaries call for an end to Vietnam's death penaltyFeb. 2, 2015 Global, Peace & Justice
Who's your favorite saint? NCR writers shareNov. 27, 2014 People
Pope Francis' address to the SynodOct. 18, 2014 Vatican
Freed Vietnamese Catholic activist: I will continue my fight for democracy, social justiceOct. 14, 2014 Global
Canadian synod results private, but bishops indicate 'good read' of situationMar. 25, 2014 Accountability, Global
AMOR conference statementNov. 21, 2013
National Catholic Reporter Publishing Company appoints managing editor as CEO/presidentNov. 20, 2013 People
New Mexico diocese begins bankruptcy processNov. 18, 2013 Faith & Parish
Francis: 'May a powerful cry for peace go up from every land!'Sep. 4, 2013 Peace & Justice, Vatican
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Timeline of a crisisJul. 6, 2015 NCR Today
Pope's USA itinerary releasedJun. 30, 2015 NCR Today
Pope's quotes: Immersed in the worldJun. 29, 2015 The Francis Chronicles
Pope's quotes: The gift of lifeJun. 26, 2015 The Francis Chronicles
Pope's quotes: FreedomJun. 24, 2015 The Francis Chronicles
US bishops say Pope Francis' encyclical is a call to examine lifestyle choicesJun. 22, 2015 Eco Catholic
Pope's quotes: A treasure for humanityJun. 22, 2015 The Francis Chronicles
World weighs in on 'Laudato Si''Jun. 18, 2015 Eco Catholic
Pope's Eco Quotes: the entire seriesJun. 17, 2015 Eco Catholic
Pope's Eco Quotes: A loan from our childrenJun. 17, 2015 Eco Catholic
Pope's Eco Quotes: Be concernedJun. 12, 2015 Eco Catholic
Pope's Eco Quotes: I had to be hereJun. 10, 2015 Eco Catholic
Pope's Eco Quotes: An inalienable rightMay. 28, 2015 Eco Catholic
Pope's Eco Quotes: People, not numbersMay. 27, 2015 Eco Catholic
Pope's Eco Quotes: The fragile worldMay. 22, 2015 Eco Catholic
Pope's Eco Quotes: A Case of ExclusionMay. 19, 2015 Eco Catholic
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Book Reviews
Mindful money use, from the pocketbook to the planetJul. 29, 2009
G. Willow Wilson: novelist, comic book writerDec. 30, 2008
Following Chaput into the political fraySep. 3, 2008
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In This Issue
July 3-16, 2015
- Francis' encyclical an urgent call to prevent world of 'debris, desolation and filth'
- Editorial: Churches can lead the fight against racism
- New family synod document a mixture of welcome, criticism of modern life
- Special Section: Women Today [Print only]
Some articles are only available in the print newspaper and Kindle edition.


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The belly flatteners that keep her ab-ilicious! Plus, the singer reveals her secrets to a balanced life.
Get more of SELF's flat-ab workouts, recipes and more.
Get more of SELF's flat-ab workouts, recipes and more.
6 Healthy and Satisfying Summer Cocktails You'll Want To Make TonightWhip up a batch and enjoy all weekend long.
Girl Power! Life Lessons from the Littlest AthletesWe asked some of our favorite young sports stars what
Which Gyms Have the Best Locker Room Swag?They're so swank, you'll want to hang out there even
"I work out four times a week—five or six if I'm being psycho, twice if I'm being lazy. My trainer, Don 'DB' Brooks, knows how to keep me from getting bored." Here are three moves that keep Fergie ab-ilicious!
Video: Behind the Scenes at Fergie's SELF Photo Shoot!


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31 years of experience
2615 E Clinton Ave
Fresno, CA 93703 Phone number & directions
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Enrique Carbajal:
View the full profile to get information on:
- Qualifications
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Patient Reviews
The overall average patient rating of Dr. Enrique Carbajal is Excellent.
|Patient Ratings
|Ease of Appointment
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|Bedside Manner
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|Follows Up After Visit
Specialties & Research
Dr. Enrique Carbajal, MD is board certified in Internal Medicine and Cardiovascular Disease.
- He has special expertise in 9 areas:
- Acute Coronary Syndrome (ACS)
- Chest Pain (Angina)
- Coronary Disease
- Heart Block
- Heart Disease (Myocardial Ischemia)
- High Blood Pressure (Hypertension)
- High Cholesterol (Hypercholesterolemia)
- Myocardial Infarction
- Unstable Angina
Education & Awards
Dr. Carbajal graduated from University of Guadalajara, Mexico, San Antonio.
Dr. Carbajal has 1 hospital affiliations:
- Central California Veterans Affairs Medical Center
Similar doctors nearby
Dr. Michael Tom
Dr. Vishal Pall
Dr. Quynn Gingrich
Dr. Tin Kyaw
Dr. Wei Gu
Dr. Nathan Stockamp
- Additional Information
- Dr. Enrique V Carbajal MD is a male Internist, has 31 years of experience and practices in Internal Medicine and Cardiovascular Disease.
- Where does Dr. Enrique V. Carbajal practice?
- Dr. Enrique Carbajal has 1 office location.
Dr. Enrique Carbajal practices Internal Medicine and Cardiovascular Disease near Fresno, CA.
See Fresno Internists and Fresno Cardiologists.


text: http://askubuntu.com – I have Ubuntu 12.04 on a notebook HP Elibook 8540w, working with the recommended additional NVidia driver. The graphic card is a QUADRO FX 1800M. Since the NVidia driver causes several problems, I tried to switch to Nouveau, following the guide lines of http://nouveau.freedesktop.org/wiki/UbuntuPackages: I Installed the xserver-xorg-video-nouveau package using Synaptic I removed the NVidia driver going to System Settings / Additional Drivers and Clicking on "Remove" I saved the minimal /etc/X11/xorg.conf file, i.e. Section "Device" Identifier "n" Driver "nouveau" EndSection Rebooting the (HowTos)


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Drawn with HB mechanical pencil and watercolor paint. This was done in the lettersketch book I got from Teela Cunningham - I love that sketchbook :) Just trying something a little different.
More Virginia Poltrack
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browse markets
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2198 days, 12 hours ago
Local produce rocks!
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Because, I have a garden and I know how hard, but rewarding can be
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We love to buy local, fresh, organic produce
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2198 days, 12 hours ago
Local produce rocks!
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2202 days, 12 hours ago
The farmers who sell the wonderful produce provide us with natural vegetables and fruits that have not been gassed or grown in some controlled environment. As a concernced consumer, this is very important to me. I have gotten to know many of them by name and look forward to seeing them every week. Thank you Farmers and Friends of the Winston Salem Retail Farmers Market!!!
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Red, White, and Blue Yarn Hanging
I have been totally obsessed with yarn hangings since they first started popping up and couldn't wait to make one of my own. I'm working on fixing
This is a great platform for both the DIY folks and the pros. I have both learned and have been able to share my knowledge. Thank you Hometalk!


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From Publishers Weekly
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I used this book as a reference for a fictional book I was writing and it proved to be invaluable for research. One of my favorite historical nonfiction books about New York!Published 1 month ago by Patrick Johnson
What a fun read! Being familiar with the area made me enoy it even more!Published 5 months ago by Biddy Mulligan
great historical account of one of america's iconic social locations. if you love NYC, you'll enjoy this. The author conveys the energy that is the crossroads of the word.Published 6 months ago by Lyn Smith
Just finished this book and it's a really great read, especially for theater fans. However, it was the first e-book I purchased from Kindle and I was hugely disappointed to see... Read morePublished 11 months ago by Solangedesantis


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Real, honest-to-goodness holograms are a thing now
If you're retiring soon, take these steps now
Join the NASDAQ Community today and get free, instant access to portfolios, stock ratings, real-time alerts, and more!
MasterCard Inc.
) announced a number of partnerships and product launches. The
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and enhance client base.
MasterCard currently carries Zacks Rank #3 (Hold).
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Healthcare Providers and Services
Company Overview of Gurwin Jewish Geriatric Center, Inc.
Executive Profile
Rosalyn C. Gordon
Vice President and Director, Gurwin Jewish Geriatric Center, Inc.
|Total Calculated Compensation
|This person is connected to 2 Board Members in 2 different organizations across 3 different industries.
See Board Relationships
Ms. Rosalyn C. Gordon serves as Vice President and Director of Gurwin Jewish Geriatric Center, Inc. Ms. Gordon serves as Vice Chairman of Huntington Hospital, Inc. She served as a Trustee of North Shore - Long Island Jewish Health System, Inc.
Corporate Headquarters
68 Hauppauge RoadPhone: 631-715-2000
Commack, New York 11725-4403
United States
Fax: 631-715-2940
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Environmental Issues: Transportation
Transportation Main Page
All Documents in Transportation Tagged carbon footprint
- Carbon Reduction Opportunities in the California Petroleum Industry
Issue Brief
- Since the adoption of the first-in-the-nation Low Carbon Fuel Standard (LCFS) in 2009, California continues to successfully reduce the carbon pollution of transportation fuels. This report looks at significant, concrete steps that the California oil industry can adopt today to curb its carbon emissions. These ready-to-deploy technologies could also go a long way to meeting the industry's responsibility under the LCFS.
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How did three Danes end up being tortured in Lebanon?
The human cost of the Greek financial crisis
30 Oct 2013 17:05 GMT | Sport, Football
CSKA Moscow's punishment after their fans racially abused Manchester City players at a Champions League match is to play in a partially closed stadium when they take on Bayern Munich later this month.UEFA's disciplinary panel on Wednesday found the Russian champion guilty for their fans' 'racist behaviour' during City's 2-1 win in Moscow last week.City captain Yaya Toure directed referee Ovidiu Hategan toward fans making monkey noises at the English club's black players. The Romanian referee is also being investigated by UEFA for not interrupting the match to order a stadium announcement, warning fans about their behaviour.CSKA's punishment applies to section D at Arena Khimki when defending champions Bayern visit on November 27.The club can appeal the partial closure order, and UEFA can also appeal to impose a tougher sanction.CSKA are the ninth club to be punished by UEFA this season for racist behaviour by fans at Champions League or Europa League matches after tougher sanctions were agreed in May.Dinamo Zagreb and Legia Warsaw have been convicted of repeated offenses and ordered to play one match in an empty stadium. Six clubs had partial closures imposed for first offenses: Lazio, APOEL, Honved, Lech Poznan, Piast Gliwice and Rijeka.UEFA did not impose a fine on CSKA, who have already earned UEFA prize money of $11.8 million just for qualifying to the group stage.UEFA opened a disciplinary case based on a formal complaint by City, and reports from Hategan and its match delegate, Tormod Larsen of Norway. However, UEFA President Michel Platini himself requested an internal inquiry to examine why the protocol was not followed to respond to discrimination incidents during matches.
Source: AP
Yaya Toure has strong words for UEFA after CSKA Moscow fans sing racist chants during City's Champions League victory.
Sport, Football
After Nigeria coach Stephen Keshi calls Tom Sainfiet crazy and 'a white dude', the Malawi FA makes a complaint.
Sport, Football, Latin America, Belgium, Brazil
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Migrants complain of being sent to squalid shelters, as France unveils plan to reduce asylum processing times.
Europe, France, Migrants
Despite reforms, lifting of sanctions and 'opening', political activists in Myanmar continue to face arrests.
Human Rights, Asia, Myanmar
Changing climate, unpredictable rains dry out the land, threaten the pastoral way of life in Somaliland.
Poverty & Development, Environment, Africa
Tensions rise as Greeks from both side of the bailout debate take to the streets to withdraw money and express angst.
Politics, Europe, Greece
Voters say no to country's multi-billion euro deal with EU as PM Tsipras says creditors must agree to restructure debt.
Politics, Europe, Greece, European Union
US Secretary of State says "genuine progress" made in talks but US still "prepared to walk away" if terms unacceptable.
Politics, Middle East, Europe, Iran, US & Canada
From Democracy to the Market - we examine the devastating impact of the Greek financial crisis on ordinary citizens.
Business & Economy, Europe, Greece
Can Afghan archaeologists take on the Chinese and the Taliban to save a 5,000-year-old archaeological site?
Arts & Culture, Asia, Afghanistan
In war-torn Afghanistan it is not the Taliban that poses the greatest threat to women - it is their own families.
Human Rights, Women, Afghanistan
After decades of tension and hostility between the two nations, has change finally come to US-Cuba relations?


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A cute Pucci piece for vacation - wear with wedges and a fine knit for day. Shown here with Emilio Pucci shoes and an Anya Hindmarch bag. 100% silk. Dry clean. Italian sizing.
Multi-colored silk sleeveless V-neck dress with signature Pucci print. Emilio Pucci dress has a contrast print around neck and under bust, falls to the knee and simply slips on.
Product code: 19141 - Need help? Contact us


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You will receive an E-Ticket for your tour/activity within 72 hours (if your tour/activity is in less than 10 days). If your tour/activity is within the next 72 hours, your E-Ticket will be processed as quickly as possible. Learn more
Take a guided tour through the harbor and idyllic canals of Copenhagen. Guides will describe the main sights and detail the most interesting moments in Copenhagen's history in Danish and English.


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Jan 29, 2015 14:42 GMT Malmberg The UK's first bus powered entirely by human and food waste has gone into service between Bristol and Bath. The 40-seat "Bio-Bus" runs on biomethane gas generated through the treatment of sewage and food waste.
Jan 29, 2015 14:42 GMT Malmberg The UK's first bus powered entirely by human and food waste has gone into service between Bristol and Bath. The 40-seat "Bio-Bus" runs on biomethane gas generated through the treatment of sewage and food waste.
Jan 14, 2015 12:13 GMT Malmberg The new Klaipeda Waterwork plant has been built in a consortium between Malmberg Water AB and the Lithuanian civil contractor, Hidrostatyba, under a turnkey contract.
Oct 28, 2014 09:00 GMT Purus International Purus has invested in new websites for all its companies and at the same time has given the company a fresh, new, digital look. This is one of the steps towards getting a clearer profile and adapting our websites for many different users.
Oct 24, 2014 10:00 GMT Purus International To ensure that our products meet our internal and external demands for quality and function, we have tested our toilets V131 and 135 in accordance with standard EN997 with German TÜV Reinland®. The toilets V131 and 135 passed all tests with statement "All requirement to the standard EN 997 for Class 1 product fullfilled".
Apr 01, 2014 08:00 GMT Purus International In order to increase our ability to pursue technical as well as commercial projects in floor gullies, Purus main area, Håkan Fridvall was appointed as Product Manager on the 1st of April 2014.
Jan 22, 2014 11:41 GMT Tapflo Group Tapflo Group is proud annouce its authorized distributor in Quito, Equador, MasterSolutions. Master Solutions is an Ecuadorian company specializing in pums, separation systems, processes and execution of engineering projects, integrates and builds for the sectors: petroleum, power generation, agro-industrial, fishing, environmental sector, recovery of industrial oils, waste sludge.
Jan 07, 2014 09:37 GMT Purus International In Sweden and Scandinavia Purus is market leader. Purus has in recent years expanded through acquisitions. To enhance the development of the international presence in the expanding sanitation market John Lidén becomes Export Manager at Purus.
Nov 18, 2013 09:40 GMT Purus International Thomas Granberg becomes new General Manager for Purus Oy in Finland from the 18th November 2013.
Feb 16, 2012 11:02 GMT Cavotec Global engineering company, Cavotec, which recently migrated its listing to the Stockholm stock exchange (Nasdaq OMX Nordic), will publish its 4Q results on Wednesday, February 29 at approximately 09:00 AM CET. A conference call for investors, analysts and media will be held at 09:30 AM CET.
Feb 16, 2012 10:20 GMT Cavotec March 2012 is set to be yet another busy month for trade shows, with innovative engineering group Cavotec present at events in USA, China, Europe, South America and the Middle East. Please get in touch with us via e-mail, Twitter or Facebook if you are planning to attend one of these events and would like to arrange a meeting.


text: Forest Lake resident Bob Sorman was 17 years old when he went down to the recruiting station and signed up for the Navy. It was one day after the Dec. 7, 1941, bombing of Pearl Harbor. This past weekend, more than 70 years after that fateful day, Sorman joined 162 men and women, veterans and [...]...Read More


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After pressure from activists and politicians for more than two years, the Los Angeles Police Department declared that they have eliminated the backlog in rape kit testing. Mayor Antonio Villaraigosa and Police Chief Charlie Beck announced that the LAPD has finally examined the 6,000 pieces of DNA evidence that languished in LAPD storage freezers for years. This evidence, which includes semen, blood, hair or other genetic materials, can help identify perpetrators of sexual assault by matching the DNA to felons in law enforcement databases.
Needless to say, the fact that these kits were not being tested was a source of outrage within the women's advocacy community. A few years ago, a Human Rights Watch report castigated the LAPD for failing to act. The LAPD explained that their understaffed labs were running far behind, an excuse that was wholly unacceptable. Finally, though, according to the LA Times,
"Police officials cobbled together several million dollars in federal grants, public funds and private donations to cover the costs of outsourcing the testing to private labs. The mayor and police officials also pressed the City Council for permission to set aside funds to add more analysts to the LAPD's lab despite a citywide hiring freeze."
Mayor Villaraigosa pledged that such a situation will never occur in Los Angeles again. "For every sexual assault evidence kit, there is an individual — a mother, a daughter, a friend — who rightfully deserves justice," he said. "We recognize that there is still a lot of work to accomplish."
It's wonderful that these kits were finally tested, but I'm not completely hopeful yet. The fact that it took years of pressure before the LAPD saw fit to process this evidence does not bode well for its commitment to testing rape kits in the future.
Read more: antonio villagiarosa, dna evidence, lapd, Los Angeles, rape, rape kits, sexual assault, sexual violence, womens rights
Photo from Flickr.
It's about GD time! This is ridiculous and unacceptable.
About time they did it.
It's very disturbing how often comments come out from police, judges etc. that effectively blame the victims of rape. It shows how little respect many men really have for women.
Any man who engages in this type of behavior is not a real man but a mere facsimile of one.
It's about time...I think the cops' problem is they just think of rape as rough sex, when they really should be seeing it as a violent physical attack causing humiliation and mental harm.
Should have been done a long time ago!
This needs to happen everywhere.
thanks for the article.
I'm glad that this is being taken more seriously
You would think that we had come further from the caves than appears to be the case.
RAPE is a HUMAN RIGHTS VIOLATION! AND A HATE CRIME! WHY IS IT NOT TREATED AS SUCH!
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Here's a fun tutorial (on The Next Web) to get you started with app icon design (and perspective) inspired by Andrew Reifman's "Bodyboss Icon 1". If you're new to designing app icons, this should give you a few tips on how and where to start.
More Diesel Laws
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Tactical Links
In the Spotlight
QPS Spotlights UH Research into Undersea Gas Emissions
A featured Client Spotlight on the website of QPS, Inc., a purveyor of marine navigation and subsea imaging software, focuses on recent research by UH scientists from the Department of Earth and Atmospheric Sciences into subsea gas emissions near Barbados.
Professional Geosciences Master's Program Reaches Milestone
Alumni, faculty and friends of the University of Houston's Professional Geosciences Master's Program gathered at Armadillo Palace to celebrate the program reaching 100 graduates.
Three Ph.D. Students Receive Research Grants
Support awarded by Gulf Coast Association of Geological Societies.
Two Ph.D. Students Receive Research Grant
Support awarded by Gulf Coast Association of Geological Societies.
Atmospheric Sciences Ph.D. Receives Prestigious Postdoctoral Research Position
Fellowship at NOAA's Earth System Research Laboratory.


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Oklahoma briefs
FNB Community Bank honored
FNB Community Bank has won the U.S. Air Force Bank of the Year award for the seventh time. President and CEO Bill Croak said his family and the business have long supported Tinker Air Force Base. The FNB branch inside the base exchange at Tinker is open every day, including weekends and holidays. The bank also operates a branch in Building 3001 on the base and has six ATMs across the base. The bank also offered deferred loan payments and financial assistance for those customers affected by the federal sequester or tornadoes, and has provided a "second chance" loan program for young service members. Bank officials also worked with Tinker Airman and Family Readiness Center to promote Military Saves Week, teaching financial literacy programs for adults and children. "This is a national award and honor that FNB Community Bank works very hard for, and we are extremely proud to have received it each of the seven times," Croak said. "FNB Community Bank is honored to have worked with and served Tinker Air Force Base military, retired military and DOD civilians for over 60 years and will continue to be committed to a strong and growing partnership with Team Tinker for many years to come."
Williams Cos. studies project
TULSA — The Williams Cos. Inc. is gauging interest in another expansion project on the Transco interstate pipeline. The proposed Diamond East Project would transport natural gas from western Pennsylvania to Transco's northeast market, which includes distribution companies and power generators in Pennsylvania, New York and New Jersey. The project, which will consist of additional compression and pipeline loops, will cost as much as $800 million, depending on customer interest and volume commitments. "Diamond East is another example of Williams' commitment to add critical infrastructure that will connect growing Transco markets to abundant, economically-priced Marcellus production," said Rory Miller, senior vice president of Williams' Atlantic-Gulf area. "Unlike competing projects designed to serve the New Jersey market pool, Diamond East is a cost-effective expansion along an existing Transco corridor."
Continue reading this story on the...


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In The Weapon of Prayer E.M. Bounds expounds on God's need of people who pray. He explains:
This softbound edition of The Weapon of Prayer is printed in large, easy-to-read type and includes spaces for journaling and reflection.
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text: The hotel is located near the train station so would be convenient for those travelling by that method. The real clue is in the word "sud" as this places it on a certain side of the main railway line which is not that easy to cross. Our sat nav took us to the opposite side of the railway from the... More


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nour97 13-15, F 11 Answers 3 Dec 13, 2012 in Romance & True Love
give him a *******
Best Answer
Love is a gift, accept it graciously. Don't question it.
Best Answer
Arrange for someone to shoot you and see if he dives in front of you.
Best Answer
Like your spelling perhaps?
Best Answer
have sex with him and see if he leaves you or tries to have sex with your friends or family members ;)
Best Answer
Wow, that's the crappiest advice I've seen all day on EP. Dude...she's a little girl! What if that were your daughter!?
Best Answer
There is no making sure.

You either risk your heart and believe him, or protect yourself and have doubt.
Best Answer
I'd go for the protect mode, myself...
Best Answer
Exactly. As long as you keep the doubt to yourself you're not hurting anyone.
Best Answer
Related Questions
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If I had the power to make sure you never existed, would you want me to make sure you never existed?TerminaHero 18-21 8 Answers 3 Aug 9, 2012 in Community
he'll buy the gold, carve the model, and make it himself.
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he could just be talking **** to make me beleive him but , hell ask me how many men i slept with while we were apart yet when i ask him about his ex an what happen he said non of...passionkillsnpassionfills 18-21, F 7 Answers 0 Aug 24, 2014 in Dating & Relationships
She hates me then she loves me. She never stays She's awesome. I think she's cheating in her boyfriend? Not sure idc enfAllLoveXOXO 18-21, M 2 Answers 0 Jan 13, 2014 in Dating & Relationships


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32 year old man | Denver, CO, USA | Seeking women 18-34 within 50 miles
What's up to all you beautiful women my name matt lookin for that special someone to chill with and get to knw!!!!
What's good Denver's finest laides lookin for that special one to kick wit and to get to knw . If this is you get back to me asap my name matt from Denver & 30 yrs old and I like to show a woman a good time eazy to get along with a good dude
Camping , Cooking , Dining out , Fishing/Hunting , Exploring new areas , Nightclubs/Dancing , Watching sports
Basketball, Billiards / Pool, Bowling, Football
I exercise 1-2 times per week.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
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|5'11" (180cms)
|5'2" (157cms) to 5'11" (180cms)
|Body type:
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|Yes, and they live away from home (2)
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Leslie Snow: Cunning kid gets chance to grow up
He's turned cunning into an art form. He's Tom Sawyer.
He sees you making a sandwich and says, "Would you mind making me one of those?" When you protest he says, "Wow, sorry to be a bother. I just thought, since you're already making one for yourself, what's one more?" Before you know it you're asking him if he wants lettuce and tomato or just cheese on his sandwich. You're adding a pickle for garnish and a bag of barbeque potato chips, his favorite. Then with an irresistible smile he says, "While you're in the kitchen, would you mind passing me that plate of cookies? You're closer." You know better than to say no. It's a battle you'll lose. Ethan is just too good at this game.
The other day I heard him say to his brother, "If people didn't make my meals for me I would be fine. I wouldn't starve. I'd just exist on nothing but Cheez-Its. Breakfast, lunch, and dinner; all Cheez-Its, all the time." I can only assume he isn't joking.
Later I challenge him to make his own lunch. With a smile I say, "OK, here's the deal. You make yourself a sandwich, I'll film you, and we'll put it on Youtube. Who wouldn't want to see Ethan Snow, at age 16, making his own meal for the first time? It will amaze your family and friends. You'll be famous."
He flashes a knowing grin and replies, "Maybe another day. Zack already made me macaroni and cheese. It needed pepper." I told you he was good.
Zack and I discuss "The Ethan Dilemma," as we've come to call it, on our way to Zack's orientation at Virginia Tech. "I don't know what Ethan will do when I go to school in the fall," he says with mock seriousness. "I do everything for him unless you and dad have already done it. I get him up in the morning because he usually forgets to set his alarm. I make sure he remembers to take his lunch. When we played soccer together, I made sure he knew when we were practicing. When we were working together, I made sure he knew when we had staff meetings. What will happen to Ethan when I'm gone? How will he function?" We both laugh. It's hard not to laugh when you're discussing Ethan. It's part of his charm.
Then I stop laughing and think about the question seriously. "I know what Ethan will do when you're gone. He'll grow up. He'll have to remember to set his alarm. He'll have to remember to take his lunch. He'll have to remember when he has soccer practice and when he has meetings. We just have to let him do it. I have to let him do it. And I have to let him stumble a few times before he gets it right."
We're quiet for a few minutes, and I realize this will be a big year for my two sons. Both of them will be on their own for the first time, Zack at college and Ethan in the safety of his own home. Both will be tested. Both will have to learn to be independent. And I'm praying both of them will learn to make themselves a sandwich when they're hungry.


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HON Nucleus Series Work Chair
HON Nucleus Series Work Chair
Weights & Dimensions
|Style: Contemporary
|Back Height: High-back
|Adjustable Height: Yes
|Heated Seat: No
|Heated Back: No
|Country of Manufacture: United States
About the ManufacturerInspired by practicality and invested in understanding the needs of its customers, The HON Company strives to establish meaningful connections resulting in product solutions and customer support that exceed market demands. As a leading designer and manufacturer of workplace furniture including chairs, storage, panel systems, tables and desks, HON's commitment to serving its customers is rooted in reliable performance and a member culture that is approachable, confident, smart and ready to serve. Headquartered in Muscatine, Iowa, The HON Company has numerous manufacturing facilities strategically located throughout the United States, and markets its products through a nationwide network of loyal dealers and retailers. The HON Company is an operating company of HNI Corporation.
HON Nucleus Series Work Chair
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OUR SKU # HN6551Nucleus Series Work Chair is also sometimes listed under the following manufacturer numbers: HONN103NR74, HONN103NT10, HONN103NT69, HONN103NT90


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Carleton Geology Alums In The News
Heather Macdonald '76 recently recognized for Excellence in Geophysical EducationJanuary 23, 2015
Heather Macdonald '76 received the 2014 Excellence in Geophysical Education Award at the AGU Fall Meeting Honors Ceremony, held on 17 December 2014 in San Francisco, Calif. The award honors "a sustained commitment to excellence in geophysical education by a team, individual, or group."
Karin Brown '08 Named Swarthmore Head Swimming CoachJune 15, 2015
SWARTHMORE, Pa. – Marian Ware Director of Physical Education and Athletics Adam Hertz has announced Karin Brown as the new head swimming coach at Swarthmore College. Brown, who will assume coaching duties for both the men's and women's swimming programs, was most recently the acting head coach at the Massachusetts Institute of Technology. "Karin stood out among a talented pool of candidates," said Hertz. "She has a firm grasp of what it takes to lead this program, and an intellectual curiosity that will complement the culture at Swarthmore. We are very excited that she has chosen to join our family."
Sara Decherd Rutzky '01 Creates An Outdoor Geology Lab On Community College CampusApril 14, 2015
Raleigh, NC - Geology students at Wake Tech Community College have the chance to study large rocks from all over North Carolina without ever leaving campus. The college introduced the Mountains to the Sea Outdoor Geology Lab at its northern campus on Tuesday. It features 12 boulders that came from as far west as Bessemer City in Gaston County all the way to Onslow County at the coast.
"It's a wonderful outreach into the community for geology," said Sara Rutzky, a Wake Tech instructor who helped design and plan the project.
Geology is the most popular lab science at Wake Tech, which is the largest community college in the state, said school President Stephen Scott... "Most of us geologists get into this wanting to be outside," said Rachel Willis, a geology major from Knightdale. "There's a big difference between reading about it and doing it."
Walter Alvarez '62 et al Dinosaur Extinction Theory DebatedJanuary 31, 2015
BOSTON — BY now the image of the demise of the dinosaurs has become iconic: a luckless tyrannosaur looking over its shoulder as a colossal fireball from heaven bears down on the horizon, the monster's death by vaporization imminent.
Hanging above the desk of the Princeton geologist Gerta Keller, though, is a different artist's depiction. This time it's a pair of tyrannosaurs — still doomed — but not by an errant space rock. In this picture they're writhing on the ground in a withered landscape as eruptions from volcanoes and fissures in the ground tear the earth apart.
These dinosaurs were killed not by the lava itself, but by the environmental catastrophe unleashed by the volcanic gases. [...]
At a meeting in October of the Geological Society of America, Walter Alvarez patiently looked on as Dr. Keller presented her work dismissing his asteroid theory. When it was time for Professor Alvarez's Berkeley collaborator, Mark Richards, to present his team's paper, Dr. Richards admitted the destructive potential of the Deccan Traps and called their proximity in the fossil record to the asteroid "the 8,000-pound gorilla in the room." Perhaps, he said, there was even a causal link between the asteroid — which induced a magnitude 12 earthquake — and the most destructive period of Indian volcanism.
Joy Crisp '79 Describes The Discovery And Implications Of Methane On MarsDecember 17, 2014
Is there life on Mars? It's a question asked time and time again. And NASA's Mars Curiosity Rover may be a step closer to answering the question. The rover has measured a tenfold spike in plumes of methane. They have been detected in a small area in the so called Gale Crater, that's the 154 kilometre wide crater Curiosity has been exploring. And it's the concentrated nature of the methane which has scientists wondering about the possibility of a life form being responsible.
Karen Noyce '75 Guides Minnesota's Bear Population Back To HealthOctober 25, 2014
Minnesota's black bear population — which now numbers 10,000 to 15,000 after peaking around 25,000 — appears to have stabilized after state officials deliberately reduced the population by boosting hunter numbers.
Bruin numbers topped out in the late 1990s and early 2000s, then fell dramatically as the Department of Natural Resources issued more permits to hunters.
"Our bear population was increasing quite fast during the 1980s and '90s, and the only way to control it was to increase the number of hunters,'' said Karen Noyce, DNR bear research biologist in Grand Rapids.
Jennifer Wenner '92 Enhances Geology With CreativityAugust 1, 2014
For Jennifer Wenner, the University of Wisconsin Oshkosh is where geology and creativity meet.
Wenner is a creative and curious person at her core, she played outside a lot as a child and had parents who encouraged her to pursue education.
"It wasn't even a question I was going to go to college," said Wenner, who was raised by parents with advanced college degrees.
But Wenner, who now has a doctorate from Boston University, didn't always know she'd pick a career choice that revolved around science.
Alton Dooley '91 Becomes Executive Director Of The Western Science Center In CaliforniaAugust 1, 2014
The Board of Directors of the Western Science Center has named Dr. Alton Dooley as the museum's new executive director. Dr. Dooley comes to Hemet from the Virginia Museum of Natural History, where he was the Curator of Paleontology. Dr. Dooley will be taking over from Dr. Bill Marshall, who is retiring.
Dr. Dooley is a graduate of Carleton College and Louisiana State University. In addition to his 15 years of experience at the Virginia Museum, he has also worked as a high school science teacher and as a college geology instructor.
John Goodge '80 Granted $9 Million To Probe Antarctic IceJuly 28, 2014
Duluth, MN (NNCNOW.com)--- "It's a BIG DEAL to do this. It's not easy," says Penny Morton, Associate Dean at UMD's College of Science and Engineering
That could be said about most any trip to Antarctica, but is especially true for a UMD professor who will be joining other researchers attempting to drill deep into Antarctic ice.
"We're able to get to parts of the ice sheet that no one has ever seen before. We can not only get deeper and older paleo climate records by drilling into the deep ice, but we're hopeful we can see what the conditions are at the base of the ice sheet," says Professor John Goodge, UMD Earth and Environmental Sciences.
Professor John Goodge is spearheading the project and he says those conditions have been widely speculated because they're up to two miles under ice.
Thanks to a nearly nine million dollar grant to UMD, a new drilling platform called the Rapid Access Ice Drill, or RAID will be constructed to be transported to Antarctica. The project speaks highly of UMD researchers.
Art Rodriguez '96 Named Dean Of Admission And Financial Aid At VassarJuly 16, 2014
After a national search Vassar has named Art Rodriguez to be the college's new Dean of Admission and Financial Aid. Rodriguez is currently the Senior Associate Dean and Director of Admissions at Pomona College (Claremont, CA), and he will begin his new position on September 1.
As the senior member of the Pomona admissions staff Rodriguez's roles range from day-to-day management of the Office of Admissions to development and implementation of admissions policy. He also has been responsible for incorporating new technologies to support the college's admissions efforts. Rodriguez began his career at Pomona in 2000 and has also served there as assistant, associate, and acting dean of admissions.


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March 20, 2015
Excellent value, can't wait to try it out.
September 21, 2014
Light weight. good sizing
September 18, 2014
Simple but solid design which was excellent for the price.
July 23, 2014
Great price and brilliant quality
June 20, 2014
Very good product and reasonably priced
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Weinz's Reviews > Just One Look
Just One Look
by Harlan Coben
by Harlan Coben
Weinz's review
bookshelves: read-and-now-must-destroy
Nov 13, 07
bookshelves: read-and-now-must-destroy
Recommended for: brainless thrillseekers with time to kill
Read in April, 2006
Why is it when people hear you enjoy reading that they automatically assume that you read the same books they do? A neighbor reccomended this one. I don't think the friendship will survive. I may have to move.
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AWS now 10X the size of its competitors: Is the cloud arms race over?
AWS finally has real competition, but you wouldn't know that from looking at Gartner's latest Magic Quadrant cloud IaaS data.
Continuous integration in the enterprise cloud: Unicorns and rainbows?
Continuous integration promises lofty benefits, automating much of the dev process and speeding up time-to-market. But as Nick Hardiman explains, it's not without its pain points.
Software Development Life Cycle AGILE vs Traditional Approaches
Software Development Life Cycle (SDLC) is a process of building or maintaining software systems. Software development life cycle is the most important element in software developme...
Software Development Life Cycle Models- Comparison, Consequences
Software Development Life Cycle (SDLC) is a well-defined and systematic approach, practiced for the development of a reliable high quality software system. There are tons of SDLC m...
Conceptual Study of Agile Software Development
In this paper, the authors consist of comparative study of agile processes. Agile processes have important applications in the areas of software project management, software schedu...
Infosys new CEO's tech background may be key in getting the Indian firm back on track
Tech visionary and former SAP CTO Vishal Sikka is the new CEO of Infosys. His credibility as a technical professional could help win customers' trust, and ultimately transform the ...
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When approached correctly, coding schools might be the answer to staffing entry-level positions on your development team. We talk to a cofounder of one coding school to learn more.
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The United States Department of Agriculture (USDA) works to support the American agricultural economy to strengthen rural communities; to protect and conserve America's natural res...
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What should business and IT executives be focusing on in the months ahead? These 10 critical areas are high on the list.


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Find out how to create compelling architectural designs using the modeling tools in Autodesk Revit software. In this course, author Paul F. Aubin demonstrates the entire building information modeling (BIM) workflow, from creating the design model to publishing a completed project. The course also covers navigating the Revit interface; modeling basic building features such as walls, doors, and windows; working with sketch-based components such as roofs and stairs; annotating designs with dimensions and callouts; and plotting and exporting your drawings.
Context ribbon tabs appear on the ribbon as you create and modify elements in Revit. In this movie, we will look at how to identify a context ribbon, when it will appear and the sorts of commands that you can expect to find in it. In addition to context ribbon tabs, the Options bar gives us feedbacks to options and commands as you execute them, so we'll also take a look at this critical interface feature as well. So I'm here in a file called Condo and it's available with the exercise files. If you watched the previous movie, we talked there about the ribbons and the QAT, and as you can see, my screen has a similar set of ribbon tabs across the top.
The ribbon tab I want to focus on in this movie is the Modify tab, so I'm going to move up here and I'm going to click on it, and I want you to take a quick look at which panels are available here on the Modify tab to start off with. You could see on the far left, we've got our Properties and our Clipboard, and all the way over toward the right we have Measure and Create, and so on. A context ribbon tacks itself on to the end of the Modify ribbon tab. So if I select an object on screen like maybe this roof object right here, you will see that the word Modify changes to include the word Roofs at the end.
It tints in this greenish color, the entire ribbon tab gets this sort of greenish tint to it, and there is a new panel that appears here, in this case containing only a single button, Edit Footprint in this particular case. Now if I select something else, like this object, you can see that, that is a Model Group and so now I get Modify and then Model Groups, and I get a Group panel and it has several buttons and commands available. If I select a railing, you'll see a similar behavior, if I select this ground plane here, this is called Topography, we'll get a similar set of commands, and so on; windows, doors, each one will give us different context buttons, but you'll notice that the entire left-hand portion of the ribbon tab remains the same.
So we still have Properties and Clipboard and Measure, and so on, it's just the stuff at the right that changes. That's what we mean by a context ribbon tab. Now I'm showing you here in the case where you select an existing object. There is another place where context ribbon tabs will appear, and that's when you create objects. So I'm going to go to the Architecture tab and I'm going to click on the Wall tool, and notice that that actually takes me over to the Modify tab, and now instead of saying Modify Wall, it says Modify Place Wall, and all the rest of it still behaves the same way that I showed you a moment ago.
The left-hand side of the ribbon tab is still the same, but all the tools on the right-hand side now are tools that we can use to help us draw new walls. If I cancel that command, maybe choose a Door command, the same sort of thing occurs, I now get a Modify Place Door. So these are also considered context ribbon tabs. Now the other items that's context sensitive that you want to be paying equal attention to is the Options bar, so right below the ribbon we have the Options bar, and you could see right now that it's completely empty. It's just a big blank gray space.
If I run a command like the Wall command, you're going to see that Options bar will populate with several options that we can choose from, in this case we could change the level of the wall or the height of the wall or the location line. I'm going to cancel that command, choose the Door command and you'll see that the Options bar in this case simply says Modify Place Door, but there is no specific options. So you don't always get options that occur there, but you want to be looking just the same. If I choose a Component command, you'll see Rotate after placement and the Level option, so it really does depend on the command, not only if you will see any options occur there, but what those specific options will be.
Now in some cases when you select an object, you'll also get commands that appear on the Options bar. Now often, it will just be the single button, Activate Dimensions, which we'll look at in a future movie, but in some cases, you'll actually see more detailed options there as well. So the point is, is that there are several places on the Revit screen and in the interface, that you want to be paying attention to as you work, because that's the feedback mechanism that Revit is using to let you know what's going on at any given time. So when you execute a command or when you select an object and you want to know what to do next, then some of the most important places to be looking are the context ribbons or the Options bar, because those are two very common places where you'll get that kind of feedback.
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