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Sometimes, it feels as if we are eavesdropping on day-to-day conversations rather than just hearing the usual litany of platitudes and regrets.
Sometimes, it feels as if we are eavesdropping on day-to-day conversations rather than just hearing the usual litany of platitudes and regrets.
"Stray Dog" largely succeeds because Granik's technique complements her subject. Both he and the film are modest in their goals and cherish the value of…
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
Nick Allen picks one of his favorite Roger reviews.
An excerpt of Tony Fitzpatrick's column, "Dime Stories," which has its first published compilation in stores this month.
Nick Allen picks one of his favorite Roger reviews.
An excerpt of Tony Fitzpatrick's column, "Dime Stories," which has its first published compilation in stores this month.
A review of Han Gong-ju from a Far Flung Correspondent.
An FFC responds to Kyle Smith's assertion that women can't enjoy GoodFellas.
America takes on Trump; "St. Elmo's Fire" turns 30; Music in Sofia Coppola's films; Chat with "Vampire Diaries" DP Darren Ganet; R.I.P. Brian Clark.
The table of contents for RogerEbert.com's complete coverage of AFI Docs 2015.
I would rather eat a golf ball than see this movie again. It tells the dreadful parable of a pro golfer who was abused by his dad, melts down in the Texas Open and stumbles into the clutches of an insufferable geezer in the town of Utopia (pop. 375), who promises him that after seven days in Utopia, he will be playing great golf. He will also find Jesus, but for that, you don't have to play golf, although it might help.
The geezer is named Johnny Crawford. He is played by Robert Duvall. Only a great actor could give such a bad performance. Duvall takes the arts and skills he has perfected for decades and puts them at the service of a flim-flam man who embodies all the worst qualities of the Personal Motivation Movement. That is the movement that teaches us that if we buy a book, view some DVDs or sit for hours in the "Conference Center" of some crappy hotel, we won't be losers anymore.
How do we know we were losers? Because we were suckers for the fraud. How will we know we are winners? When we rent our own hotel rooms and fleece the innocent. The formula of the movement can be seen at work in this classified ad: Send 25¢ for the secret of how to receive lots of quarters in your mail.
"Seven Days in Utopia" stars Lucas Black as Luke Chisholm, whose father (Joseph Lyle Taylor) has browbeaten him sadistically since childhood to force him to become a pro golfer. When Luke's game blows up on the final hole of the Texas Open, the old man turns his back on him and stalks away in full view of the TV cameras. Devastated, Luke drives blindly into the night and stumbles across the town of Utopia, where he has a Meet Cute with Johnny Crawford. Johnny runs a nearby golf resort, and wouldn't you know it, will take exactly seven days to repair Luke's truck, which is how long Johnny needs to work his spells on the young man.
Robert Duvall can play crafty con men as well as anyone. I was looking for a twinkle in his eye as he inflicts young Luke with his bull$#!t, but unfortunately I'm afraid the character is intended to be real. Only exposing him as a boring fraud could possibly redeem him. The three great secrets of golf, we learn, are to "See it. Feel it. Trust it."
Johnny Crawford's approach is a variation on the methods always used in the movies by wise old gurus to redeem clueless young men. To make Luke a better golfer, he makes him paint landscapes, go fly fishing, and attend church with him on Sunday. He forgets to train him to capture flying golf balls with a pair of chopsticks.
Johnny has a wife (Melissa Leo) who nurtures the forlorn youth. There is a pretty girlfriend who has been kept on hold for a lifetime, waiting for Luke's putt shot. The landscape is majestic; Luke spends much time regarding its vistas from horseback from high plateaus while the soundtrack swells devoutly.
Utopia is another one of those movie towns where every citizen, without exception, knows all the others and can always be found in the local restaurant. There is a TV on the wall where they all watch nothing but golf and know exactly who poor Luke is. One of the local men has his eye on the diner's comely waitress, but when the slicker turns up, does he get mean and possessive? Not a chance. The good people of Utopia have such charity that they give up their homes, families, horses, cows, waitresses and dogs to the wayfaring stranger.
Let me give you an idea what good people these are. Many things go wrong during the week. Many, many things. All this in the land beyond San Antonio. Do we hear the f-word? Do we hear the s-word? Do we even hear the d-word or the h-word? No, dear reader. This is the first general audience movie in quite some time that is rated G. Robert Duvall must seldom have had a greater challenge to overcome.
A rebuttal to Joni Edelman's piece on "Inside Out."
The July 2015 edition of The Unloved looks at Andrew Dominik's "The Assassination of Jesse James by the Coward Robert...
Three films starring Gina Lollobrigida have been released on Blu-ray; Glenn Kenny looks at them and her entire career.
MTV's Scream and CBS's Zoo premiere tonight. One is worth your time. Which one?


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Research Summary
Harry Dietz is interested in identifying the determinants of vascular wall development and homeostasis, with a particular emphasis on processes that contribute to inherited forms of aortic aneurysm. The Dietz lab also studies the role of transforming growth factor-β (TGFβ) in other manifestations of connective tissue disorders including pulmonary emphysema, skeletal muscle myopathy, myxomatous valve disease, and fibrosis.
Determinants of Vessel Wall Development and Homeostasis
Our laboratory is interested in the development and maintenance of the human cardiovascular system, particularly the structural homeostasis of the arterial wall. One goal is to understand the genetic factors that predispose to aortic aneurysm, a condition accounting for 1–2 percent of deaths in industrialized countries. While our initial approach has been to study Marfan syndrome (MFS), it is anticipated that a comprehensive understanding of this relatively rare disorder will promote a greater understanding of vascular wall biology and identify pathways that may be relevant to the more common forms of aortic aneurysm. MFS is an autosomal-dominant connective tissue disorder that affects about 1 in 5,000 individuals. Manifestations include long-bone overgrowth, skeletal muscle myopathy, lens dislocation, emphysema, mitral valve thickening and dysfunction, and aortic aneurysm with a predisposition for early vascular rupture and sudden death. In 1991, we showed that primary mutations in fibrillin-1, the major component of extracellular microfibrils, cause MFS.
Doctrine posited that microfibrils are needed for elastic fiber assembly during embryogenesis. The inference is that individuals with MFS are born with an obligate structural predisposition for the development of aortic aneurysm. Remarkably, our study of mice with targeted mutations in both copies of the fibrillin-1 gene (Fbn1) revealed normal elastic fiber formation but abnormal elastic fiber maintenance during postnatal life. Fragmentation of elastic fibers was preceded by a predictable sequence that included an intense fibroproliferative response of vascular smooth muscle cells and recruitment and activation of matrix-degrading enzymes.
Enid Neptune has shown that fibrillin-1–deficient mice show primary failure of alveolar septation in early postnatal life. This abnormality correlates with increased transforming growth factor-β (TGFβ) activation and signaling. Administration of TGFβ-neutralizing antibody can rescue alveolar septation, documenting a direct link between lung disease and cytokine dysregulation. Neptune has now focused on identifying molecules downstream of TGFβ that influence lung maturation and is exploring the relevance of TGFβ to other etiologies for developmental emphysema.
In related work, Ronald Cohn has now extended this model to the skeletal muscle hypoplasia that can be seen in MFS. Fibrillin-1–deficient mice show small muscle fibers that are also reduced in number, abnormally formed (split fibers), and surrounded by excessive extracellular matrix. This associates with increased TGFβ signaling and pronounced failure of muscle regeneration after induced injury. Cohn has shown that both steady-state muscle architecture and muscle regeneration can be rescued by TGFβ antagonism in vivo. He has also shown that excess TGFβ signaling attends failed muscle regeneration in other myopathic states, including Duchenne muscular dystrophy, and that TGFβ antagonists achieve similar protection in a validated mouse model of this disorder. Cohn and Christel van Erp are studying the relevance of this mechanism and treatment strategy to other etiologies of myopathy.
Jennifer Habashi and Daniel Judge have focused on the most critical problem in MFS, i.e., aortic aneurysm. Here, increased TGFβ activity correlates with postnatal deterioration of elastic fiber architecture, aortic wall thickening due to excess matrix accumulation, and progressive aortic root enlargement. Administration of TGFβ-neutralizing antibody greatly attenuates phenotypic severity. Habashi and Judge asked whether there is an FDA-approved drug that could mimic this effect. Attention focused on losartan, an angiotensin II type 1 (AT1) receptor blocker that lowers blood pressure (a desired effect for people with aortic aneurysm) and also leads to a clinically significant reduction in TGFβ signaling. Losartan completely prevented aortic pathology in a mouse model of MFS. Indeed, treated Marfan mice could not be distinguished from their wild-type littermates by any parameter tested. Furthermore, AT1 blockade rescued features of MFS outside of the cardiovascular system, including lung septation and skeletal muscle myopathy. On the basis of this work, the Pediatric Heart Network of the National Heart, Lung, and Blood Institute launched a large multicenter clinical trial of losartan for MFS in the fall of 2007. Members of the laboratory are attempting to expand and extend therapeutic options. Peter Matt and Florian Schoenhoff have demonstrated increased circulating TGFβ in mice and people with MFS. The level of circulating TGFβ is decreased with losartan in a dose-dependent manner and correlates with aortic size in mouse models, suggesting that circulating TGFβ may serve as both a prognostic and therapeutic marker, allowing the tailoring of therapeutic protocols to the individual. Matt and Schoenhoff are also using a mouse model of acute aortic dissection for biomarker development.
Habashi and Jef Doyle are comparing the relative benefits of selective AT1 blockade with losartan to the benefits of limiting production of angiotensin II with an angiotensin-converting enzyme inhibitor (ACEi) that diminishes signaling through both the AT1 and AT2 receptor. This addresses the current controversy regarding whether AT2 signaling is protective or detrimental in MFS. Results in mouse models of MFS document that targeting of the AT2 receptor results in larger aortic dimensions, that losartan provides significantly better protection than ACEi, and that AT2 signaling is required for the full protective effect of losartan. We are now exploring whether an AT2 agonist will be synergistic with losartan and are elucidating the mechanism of protection by AT2 signaling.
Mark Lindsay is exploring potential events downstream of TGFβ that may contribute to vascular disease. He and David Loch have found that medial cells isolated from the aortic root of patients and mice with MFS express abnormally high levels of selected vascular smooth muscle cell (VSMC) markers but fail to express markers of terminal VSMC differentiation. Lindsay is using lineage-tracing studies to determine whether this represents dedifferentiation of VSMCs derived from normal embryonic origins, or perhaps population of the aortic media with myofibroblasts derived from pathologic endothelial-to-mesenchymal transition (EnMT), a process known to be driven by TGFβ. Preliminary results support the EnMT hypothesis and suggest that agents that suppress EnMT (e.g., statins and fasudil) may be protective in MFS; this is currently being tested in mouse models. Kathleen Kent and Juan Calderon are mapping genetic modifiers of MFS, and Tammy Holm and Doyle are using mouse models to explore the relevance of noncanonical TGFβ-signaling cascades in aortic disease.
During the course of patient care, Bart Loeys and I recognized a subset of patients that had some features of MFS but showed particularly aggressive vascular disease, with rupture at aortic sizes not associated with risk in MFS and/or death in early childhood. Other distinguishing features included the common presence of widely spaced eyes, a split uvula, and generalized arterial tortuosity with a predisposition for aneurysm and dissection throughout the arterial tree. At the most severe end of the spectrum, patients showed premature fusion of the skull bones, cleft palate, foot deformities, and various forms of structural congenital heart disease. We determined that this new syndrome (now called Loeys-Dietz syndrome, or LDS) is caused by mutations in either of the two genes that encode the TGFβ receptor. Analysis of patient-derived tissues showed that the net effect is too much TGFβ activity. David Loch and Elena Gallo are using patient cells and knock-in mouse models of LDS to define the mechanisms by which heterozygous loss-of-function mutations in TGFβ receptor genes lead to paradoxically enhanced signaling and to explore treatment strategies. We have recently shown that patients with LDS have a greatly increased predisposition for gastrointestinal disease, including food allergy, eosinophilic esophagitis, and Crohn's disease. Pamela Frischmeyer-Guerrerio and Anthony Guerrerio are investigating the molecular basis for perturbations of immunologic tolerance in LDS.
Upon recognition of the significant overlap between LDS and the vascular form of Ehlers-Danlos syndrome (EDS IV), we identified TGFβ receptor mutations in a large group of patients with EDS IV who lack the type III collagen abnormalities characteristic of this disorder and fail to show the craniofacial features of LDS (now designated LDS-II). To reconcile why excess TGFβ signaling (and the attendant increase in collagen production) phenocopies a collagen-deficient state, Timothy Cooper is exploring the hypothesis that, like fibrillin-1, type III collagen negatively regulates TGFβ superfamily signaling.
We have contributed to the identification of the genes for other aortic aneurysm syndromes, including arterial tortuosity syndrome and recessive cutis laxa. The emerging view is that too much TGFβ activity is a final common pathway to arterial aneurysms, and that therapeutic strategies for MFS (e.g., losartan) hold promise for the treatment of a wide array of vascular diseases. David Kim and Gallo are defining the molecular basis of additional syndromic and nonsyndromic presentations of aortic aneurysm.
Loeys and Elizabeth Bell have recently demonstrated that domain-specific mutations in fibrillin-1 underlie stiff skin syndrome (SSS), an autosomal-dominant presentation of congenital scleroderma (progressive fibrosis and hardening of the skin). These mutations impair the physical interaction between cells and fibrillin-1 that are normally mediated by integrins. Loss of integrin signaling correlates with increased fibrillin-1 deposition in the dermis and consequent concentration of TGFβ with increased TGFβ signaling. Similar events are seen in a more common acquired presentation of scleroderma called systemic sclerosis (SSc). Bell has now made mouse models of SSS that recapitulate progressive skin fibrosis and confirm the central role of impaired integrin binding to fibrillin-1 in disease pathogenesis. These mice are currently being used to explore treatment strategies for SSS and SSc.
This work was supported in part by grants from the National Institutes of Health, the National Marfan Foundation, the Smilow Foundation, and the Scleroderma Research Foundation.
As of April 20, 2010

subset: commoncrawl


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Capital Markets
Company Overview of Dominion Financial Partners, LLC
Company Overview
Dominion Financial Partners, LLC provides investment and merchant banking services. The company provides services to industries including telecommunications, software, Internet, healthcare, medical devices, life and earth sciences, energy, distribution, retail, finance, and manufacturing. The company also provides financial advisory services equity and debt placements, and mergers and acquisitions advisory services. Dominion Financial Partners, LLC was founded in 1989 and is headquartered in Houston, Texas.
1301 Travis
Suite 1210
Houston, TX 77002
United States
Founded in 1989
Key Executives for Dominion Financial Partners, LLC
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Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at firstname.lastname@example.com.


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- Crime control is not the responsibility of landlords
- Fly over to the Poplar Grove Wings and Wheels Museum benefit
- Local leaders warn of budget deadlock's impact
- SHUTDOWN: Illinois preps for the worst
- TRRT Online Edition | July 1-7
- Governor, AG differ on legality of payroll without budget
- Regular RHA meeting a quiet affair
- Funnel clouds possible through evening
- Smoking bans a breath of fresh air to some, infuriating to others
- Experts break down the SCOTUS gay marriage ruling
Dance Company selects dancers
• Young Choreographers' Concert Oct. 8
Staff Report
Rockford Dance Company has announced their roster of dancers for the 2011-2012 season.
RDC, the resident Coronado Performing Arts Center dance company, held auditions in late August for position placement. This year, the judges were Yumelia Garcia of the Joffrey Ballet and Laura Wade, Ballet Mistress of the Gus Giordano Jazz Company.
Placement assignments are as follow:
Full Company Members: Anna Rose Gibbons, Gail Honeywell, Sara Maxey and Anna Moczynski.
Associate Members: Jessica Jaye Mackinson and Rachel Seger.
Apprentice Members: Jemma Goddard, Gabrielle Myers, Allison Tennant and Lily Wellen.
Trainee Members: Nicole Shimmins and Madeline Wellen.
RDC applauds the talent exemplified by these dedicated young artists from our Rockford community.
The public is invited to attend the Young Choreographers' Concert at 8 p.m., Saturday, Oct. 8, at The Sullivan Theater, 118 N. Main St. This performance will showcase the choreographic creativity of the dancers. Tickets are $10 and will be available at the door or by calling (815) 963-3341.
From the Oct. 5-11, 2011, issue


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I've long since been frustrated with each issue being half drawn by Phil Winslade and half by Tom Raney. The styles are vaguely similar, but half the issue looks great and half looks just so-so. This issue is no exception. Timothy Green II is on fire on the co-feature still though.There's no real good way to break down this issue into small chunks to analyze. Instead of coming to a natural close, Giffen literally grinds things to a halt . There's no more real character development or anything,...2 out of 2 found this review helpful.
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News Archive
September 14, 2006
After intense lobbying from students, university raises custodial pay and hires workers who had been employed by contractors.
September 14, 2006
California's community colleges toughen graduation requirements. Some see changes as overdue; others fear standards are too high.
September 13, 2006
Education secretary stresses opportunities for the institutions' students to benefit from new federal grant programs.
September 13, 2006
Now that the country's most visible university has decided to do away with early admissions, will anyone else follow?
September 13, 2006
Boston U. students and alumni say a new anti-vulgarity policy unjustly paints hockey fans as racist or sexist.
September 13, 2006
Sen. Tom Coburn (R-Okla.) has released the replies he has received from colleges and universities about the earmarks they receive.
September 13, 2006
Enrollment increase is led by gains for women and African Americans.
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Wed. storm uprooted 6 trees on Gilford Town Beach
GILFORD — Although the Department of Parks and Recreation hasn't gotten any official notice that there was a "micro burst" or similar weather event Wednesday evening, a storm did knock down six trees at the town beach on Lake Winnipesaukee.
Department Manager Herb Greene said the safety crew had heard the lightning reports and had already closed the beach about an hour before the storm blew through.
He said the crews were still there and took refuge in the beach house about 100 yard from the old playground. He said six trees all fell after being blown in the same direction. He said they landed on some playground equipment.
Greene said the equipment is fairly sturdy and he doesn't expect there to be any permanent damage.
Department of Public Works Operations Manager Mia Gagliardi said town crews are slated to remove the trees but have been kept busy taking care of trees that blew down in the same area of town — some of which knocked out power and damaged some houses on Varney Point.
A resident of the Varney Point area said yesterday that his neighbor's gutter was knocked off by a tree that blew down and there were branches and limbs strewn around his neighborhood.
Gagliardi said that if the property owner wants the trees for burning, they can have them but the ones that fell at Gilford Beach will be chipped up using the town chipper.
CAPTION ( tree blow down Gilford BEach) Six trees that were blown down last Wednesday night in a brief but powerful storm that slammed through the area remain on Gilford Beach yesterday morning. (Laconia Daily Sun photo/Gail Ober)
Last Updated on Tuesday, 08 July 2014 12:49
Hits: 177
Public welcome to comment on Bike Week on July 23
LACONIA — City officials from various departments will host a public meeting to review the 91st running of Motorcycle Week on Wednesday, July 23 at City Hall, beginning at 1 p.m.
Property owners, itinerant vendors, city residents and anyone else with concerns or questions about the rally are invited to attend have their voices heard.
Last Updated on Tuesday, 08 July 2014 12:42
Hits: 198
Woman wanted for identity theft & forgery in New Mexico arrested after Gilford traffic stop
GILFORD — A Laconia woman who was a passenger in a car being driven by a person accused of driving while intoxicated is being held on $2,000 cash bail on a charge of being a fugitive from justice.
Police affidavits obtained from the 4th Circuit Court, Laconia Division said Melissa Bossier, 39, formerly of Albuquerque, New Mexico but now of 735 Main Street in Laconia was indicted in the "Land of Enchantment" on December 9, 2013 for one count of identity theft, and two counts of forgery.
She had been freed on cash or surety bond of $5,000 and the warrant said New Mexico authorities would extradite her from anywhere.
Once learning this, police arrested Bossier.
While doing a physical inventory of the car before it was towed, police found a broken glass pipe inside a black purse.
While Bossier was in the booking room at the Gilford Police Department, she allegedly admitted that the glass pipe was used for smoking methamphetamine and was charged with one count of possession of the banned drug.
In an additional Gilford arrest over the weekend, police charged Shelley Anderson, 33, of 8 Cumberland Road #24 with theft by unauthorized taking for allegedly selling an $1,800 television to three guys for $150.
According to police affidavits, Anderson had been staying at the home of a friend but the two had a falling out and the male who had rented the television from Rent-A-Center had left the home temporarily while she found another place to live.
While he was gone, she allegedly took the television to a Laconia pawn shop whose owner declined to buy it from her. The pawn shop owner said he saw her sell it to three men who were outside his shop.
The pawn shop owner reported to police that he got a phone message the next day from Anderson who, he said, seemed upset. He told police he had already gotten a phone call from the manager of the Laconia Rent-A-Center, who was also looking for the television.
Around the same time, Gilford Police got an e-mail from a Laconia Police Officer who said a Gilmanton man had spoken to her about a stolen Rent-A-Center television so she passed it on to Gilford. He admitted to taking Anderson to the pawn shop but said he didn't know the television wasn't hers.
The Gilmanton man also said he saw her sell the television to the three men but said he didn't know who they were.
Judge Jim Carroll told Anderson that he would release her on personal recognizance bail for the theft but was going to hold her on $250 cash bail for violating his previous order that she refrain from all alcohol.
Gilford police said when they went to arrest her for the theft of the television, she had been drinking, however she didn't appear to be drunk.
He told her he was disappointed in her and said she needed to start making some efforts at getting sober and responsible.
Last Updated on Tuesday, 08 July 2014 12:39
Hits: 339
Chemical treatment of Lake Opechee milfoil set for July 15
LACONIA — Almost 22 acres of Lake Opechee — 16.55 acres at the northeast corner and 5.25 acres below the Lakeport Dam — will be treated with a chemical herbicide to control the growth and spread of invasive milfoil. Weather and conditions permitting, the treatment will be undertaken on Tuesday, July 15.
Aquatic Control Technology of Sutton, Massachusetts, the same firm that has treated the lake in recent years, will apply the herbicide as well as deploy divers to harvest remaining plants by hand.
Altogether, the treatment is projected to cost $22,435, of which the the New Hampshire Department of Environmental Services will contribute 40 percent, or $8.974. The remainder of the cost will be shared evenly between the city and Lake Opechee Preservation Association, with each contributing $7,702.50.
For the 24 hours following the treatment there will be no swimming within 200 feet of the treated areas. The lake water should not be used for drinking or irrigation until further notice. This restriction applies to intakes within 1,200 feet and wells within 50 feet of the treated areas.
Last Updated on Tuesday, 08 July 2014 12:34
Hits: 238
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- Selectmen seek accomodation with library trustees
- Substance abuse program not available to all who need it at county jail
- Selectmen agree Belmont should have its own police dog
- John Stevens named trustee of N.H. Community College System
- Tilton store manager beaten & robbed
- Laconia fireworks rescheduled for Saturday night


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Remember the Mystery District? They kicked off our series on homey crews you should know back at the beginning of the summer, and now the movie is done! "The Reel" is officially dropping August 26th at Newt & Harolds. Be there at 8PM for a bbq and fun times, or if you can't make it, look for the movie on the Internet, August 27th.
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Venous thromboembolism (VTE) is a common complication during and after a hospital admission. Although it is mainly considered a complication of surgery, it often occurs in people who have not undergone surgery, with recent evidence suggesting that immune-mediated diseases may play a role in VTE risk. We, therefore, decided to study the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) in people admitted to hospital with a range of immune-mediated diseases.
We analysed databases of linked statistical records of hospital admissions and death certificates for the Oxford Record Linkage Study area (ORLS1:1968 to 1998 and ORLS2:1999 to 2008) and the whole of England (1999 to 2008). Rate ratios for VTE were determined, comparing immune-mediated disease cohorts with comparison cohorts.
Significantly elevated risks of VTE were found, in all three populations studied, in people with a hospital record of admission for autoimmune haemolytic anaemia, chronic active hepatitis, dermatomyositis/polymyositis, type 1 diabetes mellitus, multiple sclerosis, myasthenia gravis, myxoedema, pemphigus/pemphigoid, polyarteritis nodosa, psoriasis, rheumatoid arthritis, Sjogren's syndrome, and systemic lupus erythematosus. Rate ratios were considerably higher for some of these diseases than others: for example, for systemic lupus erythematosus the rate ratios were 3.61 (2.36 to 5.31) in the ORLS1 population, 4.60 (3.19 to 6.43) in ORLS2 and 3.71 (3.43 to 4.02) in the England dataset.
People admitted to hospital with immune-mediated diseases may be at an increased risk of subsequent VTE. Our findings need independent confirmation or refutation; but, if confirmed, there may be a role for thromboprophylaxis in some patients with these diseases.
Venous thromboembolism (VTE), which comprises deep vein thrombosis (DVT) and pulmonary embolism (PE), is thought to account for an estimated 25,000 deaths annually in the UK [1], with a recent study suggesting that the figure might be as high as 60,000 [2]. VTE is a common complication during and after hospitalisation for acute medical illness or surgery [3]. PE accounts for 5 to 10% of deaths in hospitalised patients, making VTE the most common preventable cause of in-hospital death [3]. Risk factors for VTE include immobility, age and obesity [1].
Although VTE has traditionally been considered a surgical condition, the vast majority of hospitalised patients with symptomatic VTE have not undergone recent surgery [4]. Indeed, up to 80% of in-hospital fatal PEs occur in nonsurgical patients [4]. Patients with inflammatory bowel disease [5], rheumatoid arthritis [6], type 1 diabetes [7] and systemic lupus erythematosus (SLE) [8] are at an increased risk of VTE, suggesting that there may be a more general association between immune-mediated diseases and VTE.
To investigate this further, we undertook a record linkage study to determine the risk of VTE in individuals with selected immune-mediated diseases using the long-standing Oxford Record Linkage Study (ORLS) [9] and the more recent English national linked Hospital Episode Statistics (HES) dataset.
The Oxford Record Linkage Study (ORLS) [9] includes brief statistical abstracts of records of all hospital admissions (including day cases) in National Health Service (NHS) hospitals, and all deaths regardless of where they occurred, in defined populations within the former Oxford NHS Region. The original ORLS covered the years 1963 to 1998, and is referred to here as ORLS1. The hospital data were collected routinely in the NHS as the region's hospital statistics system and were similar to English national hospital episode statistics (HES). A second dataset, referred to as ORLS2, has been linked and built as the Oxford regional subset of the English national Hospital Episode Statistics (HES), and runs from 1999 to 2008. The data items available for linkage changed between 1998 and 1999 and the two datasets are not themselves linked together. We have also used the complete dataset of the English national HES (1999 to 2008). Death data in each of the three datasets derive from death certificates. The population covered by ORLS1 gradually expanded over time from an initial population of part of Oxfordshire (an approximately 300,000 resident population) to all four counties of the former Oxford NHS region (resident population 2.5 million); and the ORLS2 covers the same four counties. The population of England is 50 million. The datasets used in this study (versions m6v2 for ORLS and v08a for ORLS2 and England) have been constructed by staff in the Oxford Unit of Healthcare-Epidemiology.
The basic methods were the same for the analysis of each disease and are described for rheumatoid arthritis and VTE. A cohort of people with a record of admission or day case care for rheumatoid arthritis was constructed for those with a principal diagnosis of rheumatoid arthritis, as the reason for hospital care, by identifying the first admission, or episode of day case care, for the condition in an NHS hospital during the study period of 1963 to 1998 in ORLS1, 1999 to 2008 in ORLS2, and 1999 to 2008 for the whole of England. The International Classification of Disease (ICD) codes used for each immune-mediated disease can be found in Table Table11 and and2.2. The ICD codes used for VTE (DVT and PE) were: 465 in ICD 7; 450 in ICD8; 415.1, 451.1 and 453.9 in ICD9; I26 and I80.2 in ICD10. A reference cohort was constructed by identifying the first admission for each individual with various other, mainly minor medical and surgical, conditions (listed in Table Table22 footnotes). This is based on a 'reference' group of conditions that has been used in other studies of associations between diseases [10-12]. In its design, the standard epidemiological practice was followed, when hospital controls are used, of selecting a diverse range of conditions, rather than relying on a narrow range (in case the latter are themselves atypical in their risk of subsequent disease). As a check, we have studied the risk of VTE in the control conditions within the reference cohort to ensure that the reference cohort does not include control conditions that have atypically high or low VTE rates.
People were included in the rheumatoid arthritis or reference cohort if they did not have an admission for VTE either before or at the same time as the admission for rheumatoid arthritis or the reference condition. We then searched the database for any subsequent NHS hospital care for, or death from, VTE in these cohorts. We considered that rates of VTE in the reference cohort would approximate those in the general population of the region while allowing for migration in and out of it (data on migration of individuals were not available).
We calculated rates of VTE based on cohort analysis. For each broad age group of people with rheumatoid arthritis, and for VTE, we took "date of entry" into each cohort as the date of first admission for rheumatoid arthritis, or reference condition, and "date of exit" as the date of first record of VTE, death, or the end of the data file (31 December 1998 for ORLS1; 31 March 2008 for ORLS2 and English HES), whichever was the earliest. In the ORLS cohorts, in comparing the rheumatoid arthritis cohort with the reference cohort, we first calculated rates for VTE, stratified and then standardised by age (in five-year age groups), sex, calendar year of first recorded admission, and district of residence, to ensure that the results of group comparisons were equivalent in these respects. We used a similar approach to standardisation in the England dataset, stratifying by age (in five-year age groups), sex, calendar year of first recorded admission, region of residence, and quintile of patients' Index of Deprivation score (as a measure of socio-economic status). We used the indirect method of standardisation, using the combined rheumatoid arthritis and reference cohorts as the standard population. We applied the stratum-specific rates in the combined rheumatoid arthritis and reference cohorts to the number of people in each stratum in the rheumatoid arthritis cohort, separately, and then to those in the reference cohort. We calculated the ratio of the standardised rate of occurrence of VTE in the exposure cohorts relative to that in the reference cohort. The confidence interval for the rate ratio and χ2 statistics for its significance were calculated as described elsewhere [13]. Calculated in this way, the rate ratio provides a measure of relative risk of VTE in the rheumatoid arthritis cohort, compared with the reference cohort. The fact that there is unmeasured migration in the populations covered by the study, and the use of an internal reference cohort for comparison with the VTE rates in the rheumatoid arthritis cohort (and others), preclude meaningful calculation of absolute risks.
We analysed the occurrence of an admission for VTE within 90 days of the admission for each immune-related disease, and at 91 days and more, to help establish whether any elevated risk of VTE was confined to the short-term after the episode of hospitalisation or was more prolonged.
In the analysis of diabetes mellitus, we used hospital admission for diabetes mellitus when aged under 30 as a proxy for type 1 diabetes, as the type of diabetes is not well recorded in routine hospital statistics. We analysed the data for males and females separately, as well as together, to ascertain whether or not there were differences between them in risk of VTE.
Table Table11 shows the number of people in the study who were admitted to the hospital with each of the selected immune-mediated diseases; it also shows the percentage of these who were female. The number of people in each of the three corresponding comparison cohorts were: 313,716 (47% female) for ORLS1, 187,609 (46% female) for ORLS2, and 3,707,315 (41% female) for England.
There were elevated risks of VTE after hospital admission for the following individual immune-mediated diseases, in all three of the populations studied: autoimmune haemolytic anaemia, chronic active hepatitis, dermatomyositis/polymyositis, type 1 diabetes mellitus, multiple sclerosis (MS), myasthenia gravis, myxoedema, pemphigus/pemphigoid, polyarteritis nodosa, psoriasis, rheumatoid arthritis, Sjogren's syndrome, and SLE (Table (Table22 and Appendix).
In the much larger population of England, we also found elevated risks for VTE in people admitted with Addison's disease, ankylosing spondylitis, coeliac disease, Goodpasture's syndrome, Hashimoto's thyroiditis, idiopathic thrombocytopenia purpura, pernicious anaemia, primary biliary cirrhosis, scleroderma and thyrotoxicosis (Table (Table22).
High levels of risk, substantially higher than the risks associated with some of the other diseases, were found for SLE and polyarteritis nodosa. The rate ratios for SLE were 3.61 (2.36 to 5.31) in the ORLS1 population, 4.60 (3.19 to 6.43) in ORLS2 and 3.71 (3.43 to 4.02) in the English national dataset. Those for polyarteritis nodosa were, respectively, 2.88 (1.70 to 4.55), 4.36 (not quite significant with CIs of 0.90 to 12.8) and 3.53 (2.76 to 4.44). Consistently high levels of risk were also found for chronic active hepatitis, dermatomyositis and polymyositis, diabetes mellitus, MS and Sjogren's syndrome.
On the whole, the rate ratios for males and females were similar although some of the numbers in ORLS1 and ORLS2 became rather small when subdivided by sex. In the England dataset, there was a significant elevation of VTE risk in males with coeliac disease (RR 1.47; 1.26 to1.70), but not in females (1.09; 0.97 to 1.23). Similarly, the VTE rate ratio for males with Hashimoto's thyroiditis was significantly elevated (2.98; 1.86 to 4.51), but the rate ratio in females was not (1.23; 0.97 to 1.54). There were no other significant differences between males and females.
We studied the occurrence of VTE in time intervals after admission. However, subdividing the results into 0 to 90 days and 91+ days since immune-mediated disease admission did reduce power. Only MS, myxoedema, psoriasis, rheumatoid arthritis and SLE had sufficient numbers for meaningful analysis. Table Table33 shows that, in general, associations with increased VTE risk were found for these diseases at both short and long intervals.
Although we could not calculate meaningful absolute risks for the ORLS1 and ORLS2 cohorts, because of migration into and out of the Oxford region, approximate absolute risks can be calculated in the English national data. For example, there were 81,950 people in the MS cohort of whom 1,509 had an admission for VTE (1.8%) during the 10-year period covered by the study. As an approximation, in people with MS there was one case of VTE per 264 person-years at risk. Similar calculations show that 2.7% of people with SLE had an admission for VTE in the period covered by the study, and that the event rate was one case of VTE per 169 person-years at risk. These calculations assume that migration was small and that its effect was unimportant.
The ORLS1 (1963 to 1998) and ORLS2 (1999 to 2008) cover broadly the same population but at different times. The English linked dataset is completely independent of ORLS1 and it covers a far larger population in the same timeframe as ORLS2. The results of the analyses in the three datasets corroborate each other. Previous studies have found elevated risks of VTE in people with rheumatoid arthritis [6], type 1 diabetes mellitus [7], SLE[8] and inflammatory bowel disease [5]. We have not reported on inflammatory bowel diseases here as they are included in a different epidemiological study that we hope to publish separately. These previous findings, combined with our own, suggest that there may be a general association between immune-mediated diseases and the risk of subsequent VTE. This risk is not solely associated with the short term after hospital admission: for the diseases with large enough numbers to study, it was sustained over time.
The increased risks of VTE may have different underlying causes in each disease. The elevated risks may be a reflection of patients with more extreme cases of the immune-mediated diseases, in that the populations in our study are those admitted to hospital. Immobility [14], effects of treatment (corticosteroids promote haemostasis) [15] or a true effect of inflammation on coagulation [16] could all be implicated in the associations shown.
In 1856, Virchow proposed three precipitants for venous thrombosis: venous stasis, increased coagulability of the blood, and damage to the vessel wall [17]. Inflammation is a key determinant of endothelial function in both arteries and veins and results in changes in expression of selectins and cellular adhesion molecules [16]. Studies have shown that patients with VTE were more likely to have elevated plasma IL-8, IL-6, MCP-1 and TNF-α levels [18], that inflammation influences clotting factor levels [19], that an inflammatory gene is associated with VTE [20] and acute inflammation does contribute to VTE [21]. Taken together, inflammation is likely to contribute to some extent to the initiation of venous thrombus formation.
Strengths of the datasets include their size, with large numbers of fairly uncommon diseases. The ORLS1 data provide long duration of follow-up; the English data provide a much larger and more recent population but with shorter follow-up. The risk of VTE was therefore studied for a large number of immune-mediated diseases, all within a single population and using the same methodology. Accordingly, levels of risk associated with different immune-mediated diseases can be directly compared within the same study populations.
Our study should be regarded as exploratory rather than definitive. We studied a wide range of immune-mediated diseases with differing aetiologies. We did so because, as an exploratory study, with very large linked datasets in which many diseases can be studied, we saw no reason to be restrictive in our selection of diseases.
The datasets have limitations. The cohorts are based on prevalent cases, the first recorded hospital admission or episode of day case care for each person with each condition, rather than being cohorts with follow-up from the date of first diagnosis. Data are not recorded on patients who move out of the area covered by data collection or who are treated in hospitals outside the area (mainly affecting ORLS). The datasets are limited to people who were admitted to hospital, or who received day case specialist care. This would not capture all people with each immune-mediated disease, although it should identify the great majority with subsequent diagnosed VTE. These factors are part of our reasoning for including a comparison cohort of patients admitted to hospital, or in receipt of day case care, from the same database and for 'matching', through stratified analysis, for area of treatment and for year of first recorded diagnosis as well as for age and sex. The two Oxford datasets are not linked to each other due to changes in the data items available for linkage between 1998 and 1999. Consequently, it is likely that some people have been recorded as having a 'first admission' for each immune-mediated disease in each of the time periods studied.
We lack clinical and laboratory data. We lack treatment data for the immune-mediated diseases; and elements of their treatment could themselves influence VTE risk. There is very limited information on potential confounding factors such as socioeconomic status, and none on smoking or ethnicity. As we comment above, our results should be regarded as speculative rather than definitive: they represent results from what can be done using very large-scale, routinely collected administrative data. They need further work, in different study designs, to confirm or refute the findings, although epidemiological studies involving direct patient contact may be quite formidable logistical undertakings on the scale required.
Our rate ratio for VTE in people admitted to hospital with rheumatoid arthritis in the English dataset was 1.75, which is comparable with a previous study that reported a relative risk of 1.99 [6]. Our rate ratio for VTE in people aged under 30 with diabetes was 2.58 in the English dataset, which compares with a reported figure of 1.73 in hospitalised patients with diabetes aged 20 to 29 in the USA [7]. Although the literature is sparse on VTE in people with immune-mediated diseases, our findings seem broadly comparable with findings of others.
We used age at admission under 30 as a proxy for type 1 diabetes mellitus, as the type of diabetes is not routinely recorded on hospital admission records. Although this will mostly consist of people with type 1 diabetes, there may be a few people with type 2 diabetes in the cohort as well.
We studied a large number of associations between diseases. The effect of making multiple comparisons needs to be considered. For this reason, we have given exact P-values, as well as confidence intervals, so that the reader can judge the degree of significance of each immune-mediated disease and subsequent VTE. It is possible that some of the associations that are significant at a level of P < 0.05 or P < 0.01 may result from making multiple comparisons and the play of chance. This may particularly be so where there is no prior hypothesis to support the finding. On the other hand, even in a study with the number of comparisons that we have made, findings where the significance level is <0.001 or less, are unlikely to be attributable to chance alone. There were differences in levels of risk between the diseases studied: for example, the rate ratios for SLE were significantly and substantially higher than those for myxoedema. Even if the fairly low levels of elevation of risk, such as those associated with myxoedema and thyrotoxicosis, are considered unimportant, the high levels of risks associated with SLE, polyarteritis nodosa and diabetes mellitus are striking. The large numbers of findings with highly significant results in the England cohort needs comment. They no doubt in part reflect the very large numbers of patients in the cohort, such that many differences are significant, even if fairly small (for example, coeliac disease, thyroiditis, myxoedema, thyrotoxicosis), as a result of high statistical power.
This is an exploratory study into the risk of VTE in people admitted to hospital with a range of immune-mediated diseases. Further studies are needed, of individual immune-mediated diseases, in greater depth, to confirm or refute our findings. Given that a large proportion of hospitalised patients are at risk for VTE, and that there is, generally, a low rate of appropriate prophylaxis, our data suggest that patients with selected immune-mediated disease may need to be considered for thromboprophylaxis. This may be particularly warranted in people with diseases at relatively high risk of VTE, such as SLE and polyarteritis nodosa. However, the risk of VTE for any immune-mediated disease we studied is at least an order of magnitude lower than the risk of VTE after surgery[22]. Further investigation is required, prospectively, to determine the thromboprophylaxis status of patients with these immune-mediated diseases who experience VTE. If a substantial proportion of such patients are found not to have been receiving thromboprophylaxis, current recommendations on thromboprophylaxis may need to be re-examined, as the disorders we studied here were not included as risk factors in the recent NICE guidelines on reducing the risk of VTE [23]. Prospective studies are needed to determine the predictive value of inflammatory markers for VTE, but this may also aid in the identification of individuals who strongly warrant preventative therapy.
CI: confidence interval; DVT: deep vein thrombosis; HES: Hospital Episode Statistics; ICD: International Classification of Diseases; IL: interleukin; MCP: monocyte chemoattractant protein; MS: multiple sclerosis; NHS: National Health Service; NICE: National Institute for Health and Clinical Excellence; P = probability; PE: pulmonary embolism; SLE: systemic lupus erythematosus; TNF: tumour necrosis factor; VTE: venous thromboembolism
The authors declare that they have no competing interests.
MJG is the guarantor of and designed the study. SVR, MJG and CJW conceived the study. CJW led the analysis. SVR, AEH, DY contributed to the analysis and interpretation of the data. SVR and CJW wrote the first draft and all contributed to subsequent drafts and the final paper.
Observed (O) and Expected (E) numbers of people with an admission for DVT or PE in people with selected immune-mediated diseases (see Table Table44).
The pre-publication history for this paper can be accessed here:
This Unit of Health-Care Epidemiology and its work on record linkage are funded by the English National Institute for Health Research. SVR is funded by a Goodger Scholarship (University of Oxford). The funders had no role in study design, data collection, data analysis, data interpretation, writing of the report or for the decision to submit for publication. The views expressed in the paper do not necessarily reflect those of the funding bodies. All authors declare they are independent from all sources of funding.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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232 posts tagged with gender.
Displaying 151 through 200 of 232. Subscribe:
But what's it there for? Do you actually sleep on it?
Little known facts about men [more inside]
Sir / Ma'am / ???
What's the gender-neutral equivalent to "Sir" and "Ma'am"? [more inside]
He's not refusing to be a man. What to do, what to do.
difficult gift shopping filter: Help me find books, toys, comics, music, etc that provide a broad, varying, and largely non-traditional view of masculinity for my little brother, who is absolutely nothing like me or anyone else in our family. More details than necessary inside! [more inside]
Fictional M to fictional F?
Looking for fictional female characters originally written as men. [more inside]
gender-neutral first names of any ethnicity
I'm trying to put together a list of gender-neutral first names. [more inside]
There are no gay people in the future. (Or are there?)
Looking for book recs about sci-fi, specifically about gender issues and jetpack-related physics. [more inside]
My husband is transgendered. How do I tell my parents?
My husband will probably be starting hormones and this may eventually lead to gender reassignment surgery. I fully support him, however it goes. There is a lot of advice out there for how transgendered people should tell their partners or parents, but very little for how supportive partners should tell their families. Any advice? (longer story inside) [more inside]
Science Fiction films dealing with sex-change?
Science Fiction films dealing with sex-change? [more inside]
A guy and a girl singing together?
I am a music ignoramus. But, I know I really like a man and a woman (a guy and a girl) singing together. Call and response, harmony, part of the lyrics or not, I think it's really amazing when a masculine voice and feminine voice are working together. [more inside]
It seems to be a commonly acceptably statement that women are better at multi-tasking than men. Is there any research into the opposite? Purely anecdotal evidence suggests that women aren't as hot at single tasking as men, but I've never seen this suggested...
I'm Michael, not Mike. How do I get this into people's heads?
I'm Michael, not Mike. How do I make sure people know this? (Extra degree of difficulty: for a few years I was a girl, so I'm sensitive about names in some weird ways.) [more inside]
Sex without pleasure
Does there exist a culture where sex doesn't result in orgasm? [more inside]
Where is this picture from?
Where is this picture from? [more inside]
Friendships: do i just accept that I'm not gonna understand my guy friends?
Do you approach same-sex and opposite-sex friendships similarly in terms of expectations of care and respect? [more inside]
How can I adjust my ph to make it ideal for gender selection?
My husband and I are trying to have a baby girl. I have some questions about preconception gender selection techniques. [more inside]
Stupid stupid stupid
Waste of a question-filter: Can anybody remember one of those stupid "do you think more like a man or woman" tests? [more inside]
Transgender resources in SF and the BA?
Transgender resources in San Francisco and the Bay Area? [more inside]
How many men have written work under a woman's name?
Can you think of any men who write, or have written, or create in any medium, under a woman's name? (I'm excluding transsexuals, and examples such as men in Shakespearean theatre and Japanese Noh Theatre.) There are plenty of women who have written under men's names, but I can't come up with a single example of the other way round. A true situation, or just my ignorance? [more inside]
Like mother, like son?
Plenty of little boys want to grow up to be just like Dad. But to what extent (and how) are boys' interests/activities/identities influenced by their mothers? [more inside]
Looking for a picture that would be worth 1,000 words
I'm trying to find a psychological/sociological study on men and women's views of the ideal female body type. [more inside]
Do I buy blue or pink?
Is my four-months-pregnant wife carrying a boy or a girl? [more inside]
Smooch mechanics
How do you kiss? [more inside]
"I can't abide them even now and then"
Strategies for dealing with a fear of men, please. [more inside]
Mean Girls
Why don't other women like me? Women who meet me singly, or as part of a mixed-gender group usually like me. I function just fine in mixed-gender or mostly male situations. When I'm part of an all-woman group, I get bullied and scapegoated. In particular, the "queen bee" of the group almost always singles me out as a target. What am I doing wrong?
Paging all Gender Warriors!
GenderWarriorFilter: Help me find a gift for a five year old girl that in NO WAY involves princesses. Oh yeah, I should mention that I'd prefer that she also not hate said gift. [more inside]
Are you a man or woman?
When did adults in Western countries decrease using man/woman when speaking about themselves, e.g. describing their gender? How came this to be? [more inside]
Baby Boy goodness?
Flip this question: What is great about parenting a boy? [more inside]
Baby Daughter Daddy
Help me with gender disappointment. My wife and I just had an ultrasound and found out our baby will be a girl. I was hoping for a boy because I never knew / met my father. My dad was a completely absent f*ck-up. I was hoping to somehow fill that void by giving my son what I never had and teaching him the things I had to learn on my own. I know I will be overjoyed when my daughter is born, but right now, I am feeling quite sad. What is a good way to look at this, and what can I look forward to with having a girl
Gender Neutral Term for Aunt/Uncle
Searching for a gender neutral term for Aunt/Uncle? [more inside]
Undeniable Examples of Women Geniuses?
GeniusFilter: Help me win an argument and prove that there ARE undeniable examples of women geniuses throughout history or even today. [more inside]
I find it hard to maintain friendships with women
I find it hard to maintain friendships with women. What's up with me? [more inside]
Scientific formulas for happy, healthy, wise children
What are some (at least somewhat) objective studies on healthy children demographics? I'm specifically interested in single vs. multiple children, and for multiple children, differences in age, gender, relationship to parent (adoption vs. biological), and race. [more inside]
Help the average Jane with a statistics question?
An acquaintance who's a university professor on the hiring committee for his department cried 'sexism!' when 50% of the candidates who were asked back for interviews were women, when only 18% of the initial applicants for the position were women. I rebutted. Who's right? [more inside]
Form an orderly queue, ladies
How do things change (or do they change) when an IT conference is attended by 50% women? [more inside]
What should I write my paper about?
I need a topic for a paper concerning a dilemma in gender/heterosexism [more inside]
How do I get people to get my name/gender right?
My odd to pronounce/gender-unusual name gives me lots of problems. How can I diplomatically solve all of them? [more inside]
Diseases which affect gender ratio of births
Hepatitis B causes mothers to give birth to fewer girls. Are there are any other diseases that affect births in a gender-specific way?
What's the deal with male/female/man/woman grammar?
A guy becomes a "male president" but if it's a girl she is a "woman president." Can someone explain this grammar? [more inside]
She unstuffs the stuffed shirt?
What are some films, books, plays, TV shows, etc. that feature a free-spirited woman trying to get a strait-laced man to loosen up? [more inside]
Late 19th century french illustration of male as plaything
I'm trying to locate/identify a late 19th century illustration (almost certainly French) that depicts a miniature man on a table being prodded by (I think) a knitting needle held by one of 2 seated, bored looking women. [more inside]
Is my little friend male or female?
BugFilter: Is there a simple (or any) way to determine the gender of a centipede? The google, it does nothing.
What am I?
I am confused about my sexuality. [more inside]
Triumph for the geeky girl?
Hello! I am looking for examples of movies (or pop culture in general) in which the geeky, less-attractive girl gets a guy who (she thinks) is totally out of her league. [more inside]
A German gentleman writes a masculine letter of feminine love to a neuter young lady
What is the function of gendered articles of nouns in (German|Spanish|etc)? [more inside]
Can an Outty to Inney keep a secret?
Is being a transsexual a guaranteed denial for an Australian security clearance? I'm a 15-year post-op MtF. [more inside]
Why do I see so many Asian women riding in the back seat?
Not sure if this is AskMeFi material, but google returns mostly porn results for "Asian wife backseat," and I can't find any previous question: I often see Asian men driving with women (presumably their wives) in the backseat. Nobody is riding shotgun. It is definitely the exception (i.e., most putative Asian couples I see are riding side-by-side). Does anyone know what this is about? [more inside]
gender substitution in mainstream music
Can anyone think of any bands who have switched a male member for a female member or vice versa? [more inside]
Can a geek girl buy her own car without getting screwed?
Buying my first car as a female engineer -- do I need a male buddy to go with me? [more inside]
Why have people always thought this?
So, despite no one having told me this through high school, now that I'm in college I've been informed that everyone, everywhere, thinks I'm gay (and high school friends have confirmed this, now that I've asked). Men, women, doesn't matter. I am aware that I have a (very) slight lisp, which I hate because I can't control it (from birth). I am aware that I'm upbeat and tend to talk fast when excited. My body language is probably somewhat submissive, but I don't think it's THAT bad. I'm shy around a lot of women, don't make eye contact a lot, and a lot of guys don't like me because I'm not that into the "guy topics of conversation". Aside from, you know, how EFFING HOT random girl #43 is. (Cause she was!) The point is, I'm disturbingly straight and finding out what everyone really thinks has thrown me for a huge loop--not only am I being perceived as something I'm not, but it's also been (continually) detrimental to my success with women and social acceptance by guys... and I DON'T KNOW WHAT TO DO. [more inside]
What percentage of male-to-female transsexuals are lesbian in their sexual orientation after their transitions?
What percentage of male-to-female transsexuals are lesbians after their transitions? [more inside]


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To Me by Kenny Rogers - Digital Sheet Music
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Two guys in England are a little too obsessed with comics. I mean, comics are pretty awesome, but they took it to a whole new level; a very questionable level. Kelvin Borbage was 22 and his friend Daniel Knox-Hewson was 23 when they got together and formulated a very bad idea. They decided to take as many comic names as possible, mash them together, and make a name. These weren't just any names, though; they were names the boys would legally change theirs to. So, Kelvin Borbage is now legally named Baron. Well, that's his short first name. His whole name is Baron Venom Balrog Sabretooth Vader Megatron Vegeta Robotnik Magneto Bison Sephiroth Lex Luthor Skeletor Joker Grind.
Daniel, well Danny boy is now Emperor legally. His full name is now Emperor Spiderman Gandalf Wolverine Skywalker Optimus Prime Goku Sonic Xavier Ryu Cloud Superman HeMan Batman Thrash. You only wish you were as cool as them, I know.


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New York—The hype and hoopla surrounding Black Friday, Nov. 25, is already reaching a fever pitch with 24 days still to … [Read more...]
Macy's To Teach Another "Retail 101″ Class
New York—What better way to learn the ins and outs of retail than from one of the world's best known retailers?That's exactly … [Read more...]
Ukala Sydney Launches Footwear in USA
Sydney, Australia—From Down Under to around the world: that's the latest from Australian footwear brand Ukala Sydney, which … [Read more...]


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Shows you all the essential features you'll need to jump-start Windows 8—whether you work with it closely at the office or use it casually at home.
"I learn most effectively through seeing and doing and lynda.com lets me do that. The movies are very well done." —Mike I.
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The Top 10 In Action Sports
01Sam Pilgrim vs. The World: The Champion Aiming To Reclaim His Crown In A New Era Of Biking
02Eccentric Adventures Episode 2: Britain's Most Brutal Illegal Event is All About Cheese
03A Journey Into Darkness: We Went Mountain Biking in the Abandoned Mines of Slovenia
04Watch The Battle at the Berrics 2015 Finals Live Stream
05Debate: Let's Stop Hating On Parents Who Want To Raise Adventurous Kids
06Guns, Roses, And Eating Insects: Adventure Cycling in Vietnam
07Big Air Will Be In The 2018 Olympics Which Is Good News For Team GB
08From Intense Trails to Intensive Care: Dicing with Death In a Mountain Biking Paradise
09Lifting The Veil: The Truth About Women's Snowboarding In Iran
10Cool Runnings: Is Jamaica Mountain Biking's Best Kept Secret?
Videograss: Episode 8
A Snowboarding video by videograss - 6,998 views
Over the winter, the Videograss crew spent a lot of time cruising the park at Bear Mountain. Videograss's own Lance Hakker captured it all on his little digi elph camera. This is a marathon edit, so sit back and enjoy the work of Mr. Slakker.
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Town Square
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Navigation tip: Clicking on any category label will display all recent posts in that category
PALO ALTO ISSUESPalo Alto shifts housing strategy
Palo Alto, a city with a reputation for affluence and astronomic property values, is banking on small apartments scattered...Original post made on Sep. 8, 2010
Last comment by Some Facts, on Sep 12, 2010 at 4:51 pm | 36 comments | 2885 Views
PALO ALTO ISSUESCity of Palo Alto staff salaries decreased in 2010
After years of increases, the salaries of Palo Alto workers took a step in the opposite direction in 2010 as total pay dropped...Original post made on Mar. 1, 2011
Last comment by peter carpenter, on Mar 16, 2011 at 4:28 pm | 36 comments | 3122 Views
PALO ALTO ISSUESAT&T antennas get mixed reception in Palo Alto
AT&T's proposal to install cell antennas on utility poles throughout Palo Alto found a mixed reception at a public hearing...Original post made on Aug. 5, 2011
Last comment by JA3+, on Sep 8, 2011 at 1:19 pm | 36 comments | 11529 Views
PALO ALTO ISSUESStanford Hospitals terminate Blue Cross coverage
Patients with Anthem Blue Cross health insurance stopped having coverage at Stanford Hospitals and Clinics on Thursday (Sept....Original post made on Sep. 2, 2011
Last comment by Matt, on Sep 12, 2011 at 11:24 am | 36 comments | 13639 Views
PALO ALTO ISSUESPA Libraries now download books to Kindles, why do we need 5 libraries?
It is official. http://www.cityofpaloalto.org/depts/lib/news/details.asp?NewsID=1267&TargetID=140 This is now! We have...Original post made by Resident on Sep. 28, 2011
Last comment by Resident, on Oct 5, 2011 at 9:44 am | 36 comments | 2471 Views
PALO ALTO ISSUESPalo Alto looks to 'Friends' group for budget help
Faced with growing expenditures and persistent budget deficits, Palo Alto is increasingly looking to volunteers and community...Original post made on Jun. 12, 2012
Last comment by jardins, on Jun 14, 2012 at 5:52 pm | 36 comments | 1926 Views
PALO ALTO ISSUESEditorial: Posturing on parking
The last thing the downtown business community or nearby residents need is a debate over who is to blame for the parking...Original post made on Aug. 9, 2013
Last comment by The city made me do it, on Aug 16, 2013 at 6:23 pm | 36 comments | 12681 Views
PALO ALTO ISSUESCity looks to displace, aid Cubberley's homeless
With Palo Alto's ban on vehicle dwelling set to kick in early next month, city officials are scrambling to construct a safety...Original post made on Aug. 14, 2013
Last comment by Chairman Mao, on Aug 20, 2013 at 5:30 pm | 36 comments | 7317 Views
PALO ALTO ISSUESPalo Alto takes aim at construction 'blight'
The chain-link fence around the "mystery project" went up next to Gail Wooley's house on Mariposa Avenue nearly seven years...Original post made on Sep. 23, 2013
Last comment by JoAnn, on Sep 29, 2013 at 2:06 am | 36 comments | 5066 Views
PALO ALTO ISSUESPalo Alto treads carefully on new garages
Faced with a citizenry upset about downtown's deepening parking shortages and businesses anxious about looming parking restrictions,...Original post made on Feb. 11, 2014
Last comment by baleylanger, on Mar 6, 2014 at 4:36 am | 36 comments | 140361 Views
PALO ALTO ISSUESThree critically injured after car crashes into downtown coffee shop
Three people were critically injured in downtown Palo Alto on Thursday afternoon after a vehicle crashed into University...Original post made on Jul. 31, 2014
Last comment by Nora Charles, on Aug 2, 2014 at 12:01 pm | 36 comments | 27001 Views
PALO ALTO ISSUESInvitation only candidates meeting
On Wednesday there was a by invitation only meeting with three of the candidates for city council-- Holman, filseth and Dubois....Original post made by Rupert of henzau on Aug. 1, 2014
Last comment by village fool, on Aug 7, 2014 at 11:34 pm | 36 comments | 907 Views
PALO ALTO ISSUESResidents catch city wasting water
One day after the City of Palo Alto adopted water-use restrictions for businesses and residents, mushrooms growing in city...Original post made on Aug. 8, 2014
Last comment by musical, on Aug 9, 2014 at 3:54 am | 36 comments | 6965 Views
PALO ALTO ISSUESMitchell Park Library close to complete, but legal battle looms
Since a new contractor was brought on last February to finish the long-stalled Mitchell Park Library project, a "night and...Original post made on Aug. 9, 2014
Last comment by Sea-SEELAM REDDY, on Aug 12, 2014 at 3:39 pm | 36 comments | 5863 Views
PALO ALTO ISSUESPalo Alto police deny ticket-quota allegations
The Palo Alto Police Department is vehemently denying claims made by three anonymous officers in an NBC Bay Area report that...Original post made on Aug. 14, 2014
Last comment by CrescentParkAnon., on Aug 15, 2014 at 11:44 pm | 36 comments | 7060 Views
PALO ALTO ISSUESZipcar pulls up in downtown Palo Alto
Palo Alto's carless commuters and residents now have their pick from 10 available-for-rent Zipcars, thanks to the car-sharing...Original post made on Aug. 28, 2014
Last comment by Mark Weiss, on Sep 6, 2014 at 12:17 pm | 36 comments | 6620 Views
PALO ALTO ISSUESDowntown residents, workers near consensus on parking
It took decades of dreaming, years of complaining and months of painstaking negotiations, but a residential parking-permit...Original post made on Sep. 11, 2014
Last comment by long time resident, on Sep 15, 2014 at 1:56 pm | 36 comments | 5157 Views
PALO ALTO ISSUESSkeptical council not sold on Page Mill development
A plan to replace four homes on a busy stretch of Page Mill Road with a three-story building featuring apartments, office...Original post made on Jan. 27, 2015
Last comment by resident 1, on Jan 29, 2015 at 12:33 pm | 36 comments | 6488 Views
PALO ALTO ISSUESNever a drop to waste
Palo Alto resident Sue Kemp has long since turned off her automatic watering systems and tends by hand to the plants and...Original post made on Apr. 17, 2015
Last comment by Online Name, on Apr 28, 2015 at 11:40 am | 36 comments | 5109 Views
SCHOOLS & KIDSOur Town: After the Mandarin debate
0...Original post made on Jun. 20, 2007
Last comment by Parent, on Jun 29, 2007 at 9:22 pm | 36 comments | 9704 Views
Calave wine bar opens in Palo Alto
By Elena Kadvany | 12 comments | 2,903 views
OK I Changed The Title
By Laura Stec | 21 comments | 1,474 views
Family Outing - Inside Out
By Cheryl Bac | 0 comments | 777 views
Relay for Life, Menlo Park, August 8
By Chandrama Anderson | 0 comments | 533 views


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Ranger Guided Tours
NPS Photo
Dates: Memorial Day through Labor Day, Daily
Time: 10:30 am
Locations: Wright-Dunbar Interpretive Center & Huffman Prairie Interpretive Center
Fees: No Fees
Come to the park for daily ranger programs during the summer (Memorial day to Labor day). Tours are available at both Visitor Centers. A park ranger will offer a daily program at 10:30 am on various subjects that may include a neighborhood walk of the Wright-Dunbar neighborhood, the Wright memorial, Huffman prairie, the Wright bicycle company, Dunbar's poetry, and many other topics. Program schedules may be adjusted to staff availability.


text: 000 AWUS84 KSJT 042033 RWSSJT REGIONAL WEATHER SUMMARY NATIONAL WEATHER SERVICE SAN ANGELO TX 333 PM CDT SAT JUL 4 2015 Late this afternoon, skies were partly cloudy across the Lone Star State. Winds were generally from the south southeast at 5 to 10 mph. Temperatures were mainly in the 80s and 90s. Your forecast summary for West Central Texas, dry conditions should prevail for most areas through the weekend. Afternoon highs will climb into the low to mid 90s through the July 4th weekend. Lows will remain mostly in the low to mid 70s. $$ 18


text: The The Year of the Rat wiki last edited by pikahyper on 06/19/14 03:34AM View full history Featuring guest artist Steve Yeowell (STARMAN, THE INVISIBLES) and an appearance by the Clown Prince of Crime! Harley is about to cross the line from wacky to just plain insane! Bishop, the cop who's sworn to take down Harley for killing his partner, has unknowingly met her under her fake civilian guise of psychiatrist Jessica Seaborn. Now, Harley has accepted a date with this not-so-fine example of Gotham's finest. And just to keep Harley on her toes, Cupid has sent a certain psychotic ex-paramour to turn this into the strangest date in the history of love! Can you say…The Joker?


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Local lawmaker questions projected gambling revenue figures by T.W. Budig ECM Capitol reporter The Vikings' stadium bill is moving to the House floor for the first time. The House Ways and Means Committee Monday, April 23, blew a breath of life into the stalled Vikings' stadium initiative in the...Read More
Minnesota Legislature
by T.W. Budig ECM Capitol reporter The Republican Senate Monday, April 23, passed its game and fish bill, one including proposed hunting and fishing license fee increases. But the fee increase provision was markedly changed on the Senate floor. Senate Minority Leader Tom Bakk, DFL-Cook, successfully...Read More
by T.W. Budig ECM Capitol reporter Outdoors men and women rallied in the State Capitol Rotunda Monday morning (April 23), calling on lawmakers to pass hunting and fishing license fee increases. One proponent, clutching dollars in upraised fists, begged lawmakers to take the money. The Republican Se...Read More
by T.W. Budig ECM Capitol reporter A Senate committee today (April 20) passed the first Vikings' stadium bill in the Senate this legislative session, Sen. Julie Rosen's bill passing the Senate Local Government and Elections Committee on an 8 to 6 vote. "I think it helped to have the (National...Read More
by T.W. Budig ECM Capitol reporter National Football League Commissioner (NFL) Roger Goodell left a meeting with Democratic Gov. Mark Dayton and legislative leaders this morning (April 20) at the State Capitol talking about a productive meeting and dismissing the idea his presence served a threat....Read More
There is a bill that if passed by the Minnesota Legislature would allow the public to use publicly owned or managed shooting ranges, some in local police stations. It originated in the city of Plymouth, where a firearms safety instructor wanted to use the police shooting range to teach firearms safe...Read More
by T.W. Budig ECM Capitol reporter It's back. A group of bipartisan lawmakers and Ramsey County officials at a hastily called press conference Wednesday, April 18, made a late-session pitch for an Arden Hills Vikings stadium. The pitch came short days after the Minneapolis Vikings stadium proposa...Read More
by T.W. Budig ECM Capitol reporter Sen. Geoff Michel considers it a victory. After hours of meandering debate, the Senate Ethics Committee Tuesday, April 17, adjourned without rendering a decision on the issue of probable cause regarding an ethics complaint filed against Michel by a Democratic St. ...Read More
by T.W. Budig ECM Capitol reporter A hunting and fishing fee increase initiative that drew former Minnesota Vikings' coaching great Bud Grant to the State Capitol might be stalled. The Republican Senate today (April 17) on a 27 to 39 vote rejected an amendment to the Senate game and fish bill that...Read More
by T.W. Budig ECM Capitol reporter The Republican House passed its environment and natural resources policy bill Thursday, April 5, legislation that seeks to keep the Minnesota Zoo and state parks open in the event of state government shutdowns. And it creates a Children's State Forest as a means ...Read More
by T.W. Budig ECM Capitol reporter A Vikings' stadium bill and means for the state to fund its share of the proposed $1 billion, so-called "People's Stadium" in downtown Minneapolis was approved by a House committee Monday, April 2. Rep. Morrie Lanning, R-Moorhead, saw his stadium legislatio...Read More


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"We can't predict tornadoes until they happen, but we're looking for strong storms with hail and damaging winds (today). It should be an interesting day."
Related quotes
"I have always believed that God never gives a cross to bear larger than we can carry. No matter what, he wants us to be happy, not sad. Birds sing after a storm. Why shouldn't we?"
"Birds sing after a storm; why shouldn't people feel as free to delight in whatever remains to them?"
"Faith is not simply a patience that passively suffers until the storm is past. Rather, it is a spirit that bears things - with resignations, yes, but above all, with blazing, serene hope."
"Thousands of people have been lost, and [people] continue to be lost today in heavy storms. Yet our numbers are down. So the beneficial change has just been enormous."
"It was a perfect storm for gold today. Lower dollar. Higher oil prices. Base metals rallying. Commodity interest across the board. Funds are not afraid of buying on new highs."
"We're watching these winter storms very carefully as well as the storm surge and surf conditions that are off our coast, because all of that combine to create some real serious situations for us."


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Aisle Runner! If you are planning your big day in Dubai / UAE, you can always have the red carpet aisle from the hotel and it is included in most of Hotel wedding packages, 84 more words
Tags » Beljour
The wedding dress of Queen Victoria was worn by Victoria, Queen of the United Kingdom, at her wedding to Prince Albert of Saxe-Coburg and Gothaon 10 February 1840. 171 more words
We are so delighted to know that we were highlighted among the top fashion designers on Tarde Arbai ! Read the article below ,
Top fashion designers showcased at the Wedding Fair… 265 more words
We are glad to announce our latest partnership and first ever with InterContinental Dubai Festival City as they present the first ever interactive wedding fair 'I Do' this February. 103 more words


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Mercedes-Benz's 300 SL claimed 2nd in the Mille Miglia; 1-2-3 in the Berne, Switzerland, Sports Car Race; 1st and 2nd at Le Mans; 1-2-3-4... More
This 1956 Mercedes 300C Sedan. Blue with gray interior. Extremely rare RHD. Excellent original car for easy restoration. For only ... More
1956 MERCEDES BENZ 190SL W121 - 4 Speed Manual Overall a great candidate for partial restoration. Runs and drives, needs new brakes and full service and tune... More
Mercedes Benz 190 SL in a very good overall condition. Has been restored and mechanically rebuild some years ago. Body very solid and with... More
We're pleased to offer this attractive "turn-key" 190SL: Chassis #121042-10-6502147 Engine #12192-7500097 (does not match data card) Body #65-01622 Paint code: 040 >Long time current ownership >Previously a black CA... More
Mercedes Benz 190SL 1956 restored in very good condition Very beautiful restored 1956 Mercedes Benz 190SL in Silbergrau with darkblue leather interior and darkblue mohair... More
Additional images and a complete description of this vehicle will be available closer to the auction dates. Please check back for more information.... More
MERCEDES-BENZ: 1956 190SL, very good condition, solid, runs excellent, new interior. 440-546-9121, OH; [email]... More


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Africa Topics
Democracy Now! stories, posts and pages that relate to Africa
- Extreme weather from Texas to Somalia may indicate that a new era of climate war is upon us. Just this month, massive floods have shut down two nuclear power facilities in Nebraska. In New Mexico, the nation's top nuclear weapons lab in Los Alamos is being threatened by an uncontrolled wildfire. Meanwhile, the United Nations warns the Horn of Africa is facing its worst drought in 60 years, affecting more than 10 million in Djibouti,...June 30, 2011 | Story
- African heads of state are convening today in Equatorial Guinea for a week-long African Union summit. There has been a wave of arrests leading up to the summit, with police detaining an estimated 100 people. Human Rights Watch reports Equatorial Guinea is rife with politically motivated harassment, arbitrary detentions and unlawful killings. The country's government also faces criticism for spending an estimated $830 million to build a city...June 23, 2011 | Story
- A new report raises questions about the connection of Harvard, Vanderbilt and other U.S. universities to European financial interests buying or leasing vast areas of African farmland. Called "Understanding Land Investment Deals in Africa," the report by the Oakland Institute claims farmers in Africa are being driven off their lands to make way for new industrial farming projects backed by hedge funds seeking profits and foreign countries...June 20, 2011 | Story
"There is a Women's Spring Beginning": Playwright Eve Ensler and Congolese Activist Christine Schuler Deschryver on Gender Violence in CongoA newly published study in the American Journal of Public Health estimates more than two million women have been raped in the Democratic Republic of Congo since 2006. But women's advocates say there is also positive news coming from the DRC. The group V-Day, a global movement to stop all forms of gender-based violence, recently held the opening ceremony for the City of Joy, a groundbreaking new community that will be run by women survivors of...June 07, 2011 | Story
- Up to two billion people around the world tuned in to watch the British royal wedding of Prince William and Kate Middleton, a story which has dominated TV news for weeks. The wedding buzz offers a chance to look at the monarchy, Britain's domestic policy, and how its colonial legacy around the world affects foreign affairs today. While all eyes were on the wedding procession and the first kiss, Democracy Now! spoke with Johann Hari, a...April 29, 2011 | Story
- Supporters of the internationally recognized Ivory Coast president, Alassane Ouattara, have captured strongman Laurent Gbagbo, ending a four-month standoff that left hundreds dead. Gbagbo had refused to leave office since the country's presidential election in November, which the United Nations says Ouattara won. Although the political standoff has come to a close, Ivory Coast remains in deep turmoil. At least 1,000 people are thought to have...April 12, 2011 | Story
- Ivory Coast leader Laurent Gbagbo is battling to remain in power as rival Alassane Ouattara's forces surround the main city of Abidjan. Much of the fighting is concentrated around Gbagbo's heavily fortified presidential palace. Ouattara's forces are estimated to control as much as 80 percent of the Ivory Coast. We speak to Corinne Dufka, senior researcher in the Africa Division of Human Rights Watch, and Ivory Coast political...April 01, 2011 | Story
- In Libya, troops loyal to Col. Muammar Gaddafi are locked in intense fighting with opposition forces for control of several cities and towns across the country. While the battles rage in Libya, calls are growing on the international community to impose a no-fly zone to cripple Gaddafi's air force. We go to Libya, where Democracy Now! correspondent Anjali Kamat interviews Essam Gheriani, a field member of the February 17th Coalition, and...March 10, 2011 | Story
- Forces loyal to Col. Muammar Gaddafi have launched fresh air strikes on Libyan towns captured by anti-government opposition in a popular uprising over the past two weeks. Gaddafi has lost control of the eastern half of Libya, and thousands of protesters are thought to have been killed by Gaddafi's forces. We get reports from two journalists on the ground in Libya: McClatchy's Nancy Youssef in Brega, and The Observer's Peter...March 03, 2011 | Story
- Forces aligned with Libyan leader Col. Muammar Gaddafi have launched new assaults to regain control of several towns captured in a popular uprising over the past two weeks. Meanwhile, two U.S. warships have moved through the Suez Canal into the Mediterranean Sea toward Libya under orders by U.S. Defense Secretary Robert Gates. As talk of potential Western military intervention grows, we speak to Horace Campbell, a professor of African American...March 02, 2011 | Story
Show for Jun 30, 2015
Tens of Thousands Protest Austerity as Greece Faces Default
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Exonerated Death Row Prisoner Glenn Ford Dies at 65


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Deron Williams does pushups after Mirza Teletovic's three (VIDEO)
Oct 9, 2013, 2:02 AM EDT
If Deron Williams has to do this every time Mirza Teletovic hits a three this season, Williams is going to build up those pecs — Teletovic can knock that shot down.
During Brooklyn's exhibition game Tuesday night, in the fourth quarter when Teletovic hit a three, teammates waived over D-Will to do a few pushups (Teletovic was 3-of-7 from three but it only happened once).
Williams had the night off and, thanks to a great play from Wizards rookie Glen Rice Jr., the Nets had to go to overtime to beat the Wizards 111-106.
- spree8 - Oct 9, 2013 at 4:11 AM
so d-will doing push-ups is worthy of an article but Rice Jr.'s amazing putback dunk that forces the OT ain't. why is that again?
- ji8888 - Oct 9, 2013 at 5:18 AM
Oh Deron already acting obnoxious in a pre season game? So what else is new.
- dmitchell624 - Oct 9, 2013 at 3:53 PM
Actually Kurt, he did it all three times. Watch the game, i have it on DVR
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Information on "International Organizations" and "Switzerland"
December 2014
foraus – Swiss Forum on Foreign Policy
Zürich, Switzerland
The foraus - Swiss Forum on Foreign Policy is a non-partisan and independent think tank generating recommendations for Swiss foreign policy decision-makers and the broad public. More on «foraus – Swiss Forum on Foreign Policy»
June 2009
Berne Declaration (BD)
Zurich, Switzerland
The Berne Declaration (BD) is an independent, nonprofit organization that works to establish more equitable relations between Switzerland and underprivileged countries. More on «Berne Declaration (BD)»
September 2008
European Free Trade Association (EFTA)
Geneva, Switzerland
The European Free Trade Association (EFTA) is an intergovernmental organization set up for the promotion of free trade and economic integration to the benefit of its four member states: Iceland, Liechtenstein, Norway and Switzerland. More on «European Free Trade Association (EFTA)»
August 2008
Swiss International Chamber of Commerce (ICC)
Zurich, Switzerland
The Swiss International Chamber of Commerce's (SICC) principal goal is to promote international trade. More on «Swiss International Chamber of Commerce (ICC)»
Swiss Federal Department of Foreign Affairs Integration Office
Bern, Switzerland
More on «Swiss Federal Department of Foreign Affairs Integration Office»
Mandat International
Genève , Switzerland
Mandat International and its welcome center provide information, documentation, support and accommodation for international conferences and meetings in Geneva, Switzerland (UN, ILO, WHO, HCR, UNCTAD, UNAIDS, WMO, IOM, etc. More on «Mandat International»
Swiss Red Cross
Bern, Switzerland
The Swiss Red Cross (SRC) is a member of the International Federation of Red Cross and Red Crescent Societies. More on «Swiss Red Cross»
July 2008
Europa Forum Lucerne
Lucerne, Switzerland
More on «Europa Forum Lucerne»


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But when I do, I make a beeramid.
What better way to celebrate Halloween than a pumpkin filled with alcohol? Let me guess: you were just on autopilot and you were going to carve Ecce Homo into your pumpkin this year? Well think again!
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Overall: 5.0 / 5 based on 2 reviews
2 of 2 reviewers would recommend this product to a friend.
By: Sunny23 from Memphis, TN
This best has exceptional quality and is true to appearance. I received a compliment within the first hour of wearing my new belt. Well done Orvis! I am a 32 waist and I ordered a 34. perfect fit.
Exotic and Cool -
By: Texasfun from Missouri
In addition to exotic and cool, this product has quality and workmanship that are superb. I will not wear this belt for rough , dirty work. Then again, I am retired and avoid all types of work. I own less expensive belts that hold my pants up just fine. None of these are in a class with this product.