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Billionaire hedge fund manager John Paulson is setting up to bet more on Europe with a new "event" fund.» Read More
Jessica Bridge from Ladbrokes puts odds on who will be the next pope.
The Group of Seven nations are considering issuing a statement reaffirming their commitment to "market-determined" exchange rates in response to heating rhetoric about a currency war.
Norway's $700 billion oil fund made its first property purchase in the United States, buying minority stakes in five assets for around $600 million from financial services firm TIAA-CREF.
Austerity as the solution to the euro zone's protracted debt crisis could be on the way out if another bad set of euro zone gross domestic product (GDP) numbers are released this week, according to Carl Weinberg, chief economist at High Frequency Economics.
A quick check on what investors need to know as the week kicks off trading, with Scott Shellady, Trean Group.
Paul McCulley, Global Interdependence Center, and Rebecca Patterson, Bessemer Trust, size up the U.S. economy, and weigh in on how political uncertainty is impacting the markets.
CNBC's Ross Westgate reports European shares were mixed in Monday morning trading, ahead of a meeting of euro zone finance ministers.
As leaders from around the world meet this week to discuss fears of competitive currency devaluations, analysts told CNBC the currency war could lead to a sharp rise in gold prices in the second half of this year, after a falloff in the first half.
Commercial banks took no overnight emergency funds from the ECB, data showed on Monday, pointing to a consistent improvement in money market access this year.
As Britons choke on discovering they may have eaten horse that was imported as beef, this new scandal has exposed the sometimes murky labyrinth by which food reaches Europe's dinner tables.
Steve Sedgwick takes you through the European market open. With Asian indices closed for Chinese New Year.
Adrian Bignell, fund manager at Invesco Perpetual, tells CNBC why those brands with strong international exposure are the ones which offer the best prospects in Europe.
Ulrich Hackenberg isn't yet a household name but if Volkswagen's $70 billion bet on his big idea pays off, he may join the likes of Henry Ford in the canon of auto industry pioneers.
French efforts to divert Europe from economic austerity have foundered twice in a week due to German resistance, underlining a growing policy divide that is hobbling the core partnership.
Spain's prime minister published his tax returns on Saturday in a bid to quell reports he and other conservative politicians received secret cash payments but the opposition said many questions remain unanswered.
Rebounding banks helped European shares recover on Friday after data pointing to a potentially stronger recovery in global growth helped drive demand for equities.
CNBC's Simon Hobbs reports on all the market moving events in Europe today, including
European Union leaders reached agreement on the first ever cut in their common budget on Friday after 24 hours of talks, seeking to placate millions at home struggling through government cutbacks and recession.
Tom Elliott, global strategist at JP Morgan Asset Management, tells CNBC why the EU budget deal has given enough to austerity-driven northern Europe to ease future negotiations.
As the week closes out, Spanish and Italian leaders are worried that the market may once again be turning on them. It's the worst week in a long time for both countries' bond markets as each saw their yields climb above 5 percent.
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Alexandra Pitta-Chazapi, board member for the Athens Chamber of Commerce, discusses the problems facing Greek families and businesses because of capital controls.
Kiran Ganesh, multi asset strategist at UBS Wealth Management, explains why the dip in European stock markets is a buying opportunity for investors, in spite of the problems in Greece.
Stefan Ingves, governor of Sweden's central bank, defends the bank's decision to cut interest rates, shocking the markets.


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Biltmore Towers - Senior LivingDayton, OH 45402
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subset: commoncrawl


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The London Bridge to Victoria route is being delayed
Alexandra Rucki, Senior Reporter / / News
Train services across South London are being delayed due to a train fault.
The London Bridge to Victoria route is being delayed, with the service starting from Balham more than half an hour late.
A tweet from Southern Rail UK said: "INFO: 07:53 London Bridge to London Victoria will be started from Balham at 08:25 due to a train fault."
Frustrated commuters have been venting their anger on social networking websites.
Jonathan Byrant wrote: "Morning @SouthernRailUK. 8:25 Streatham hill to Sutton back to eight minutes late again so I'll miss my connection at crystal palace yet again.
"I see the claim today is over running engineering works. @SouthernRailUK pants on fire methinks."
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Train services in Sutton, Balham and Streatham suffering delays
Southern Rail must be easily the worst train company around at the moment, I honestly can't recall one day this year where one of my trains hasn't been delayed for one bogus reason or another.
So glad I'm paying extra for this "improved" service
So glad I'm paying extra for this "improved" service


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Are you Jan Barciszewski?Claim your profile
Publications (241)715.17 Total impact
Article: Chemical Biology of Nucleic AcidsACS Chemical Biology 06/2015; 10(6):1358-61. DOI:10.1021/acschembio.5b00320 · 5.36 Impact Factor
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ABSTRACT: Malignant gliomas represent the most devastating group of brain tumors in adults, among which glioblastoma multiforme (GBM) exhibits the highest malignancy rate. Despite combined modality treatment, GBM recurs and is invariably fatal. A further insight into the molecular background of gliomagenesis is required to improve patient outcomes. The primary aim of this study was to gain broad information on the miRNA expression pattern in malignant gliomas, mainly GBM. We investigated the global miRNA profile of malignant glioma tissues with miRNA microarrays, deep sequencing and meta-analysis. We selected miRNAs that were most frequently deregulated in glioblastoma tissues, as well as in peritumoral areas, in comparison with normal human brain. We identified candidate miRNAs associated with the progression from glioma grade III to glioma grade IV. The meta-analysis of miRNA profiling studies in GBM tissues summarizes the past and recent advances in the investigation of the miRNA signature in GBM versus noncancerous human brain and provides a comprehensive overview. We propose a list of 35 miRNAs whose expression is most frequently deregulated in GBM patients and of 30 miRNA candidates recognized as novel GBM biomarkers. Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.Molecular oncology 03/2015; DOI:10.1016/j.molonc.2015.03.007 · 5.94 Impact Factor
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ABSTRACT: Genetic transformation of mitochondria in multicellular eukaryotes has remained inaccessible, hindering fundamental investigations and applications to gene therapy or biotechnology. In this context, we have developed a strategy to target nuclear transgene-encoded RNAs into mitochondria in plants. We describe here mitochondrial targeting of trans-cleaving ribozymes destined to knockdown organelle RNAs for regulation studies and inverse genetics and biotechnological purposes. The design and functional assessment of chimeric RNAs combining the ribozyme and the mitochondrial shuttle are detailed, followed by all procedures to prepare constructs for in vivo expression, generate stable plant transformants, and establish target RNA knockdown in mitochondria.Methods in molecular biology (Clifton, N.J.) 01/2015; 1265:227-54. DOI:10.1007/978-1-4939-2288-8_17 · 1.29 Impact Factor
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ABSTRACT: The generally accepted model of the miRNA-guided RNA down-regulation suggests that mature miRNA targets mRNA in a nucleotide sequence-specific manner. However, we have shown that the nucleotide sequence of miRNA is not the only determinant of miRNA specificity. Using specific nucleases, T1, V1 and S1 as well as NMR, UV/Vis and CD spectroscopies, we found that miR-21, miR-93 and miR-296 can adopt hairpin and/or homoduplex structures. The secondary structure of those miRNAs in solution is a function of RNA concentration and ionic conditions. Additionally, we have shown that a formation of miRNA hairpin is facilitated by cellular environment.Looking for functional consequences of this observation, we have perceived that structure of these miRNAs resemble RNA aptamers, short oligonucleotides forming a stable 3D structures with a high affinity and specificity for their targets. We compared structures of anti-tenascin C (anti-Tn-C) aptamers, which inhibit brain tumor glioblastoma multiforme (GBM, WHO IV) and selected miRNA. A strong overexpression of miR-21, miR-93 as well Tn-C in GBM may imply some connections between them. The structural similarity of these miRNA hairpins and anti-Tn-C aptamers indicates that miRNAs may function also beyond RISC and are even more sophisticated regulators, that it was previously expected. We think that the knowledge of the miRNA structure may give a new insight into miRNA-dependent gene regulation mechanism and be a step forward in the understanding their function and involvement in cancerogenesis. This may improve design process of anti-miRNA therapeutics.PLoS ONE 11/2014; 9(11):e113848. DOI:10.1371/journal.pone.0113848 · 3.53 Impact Factor
Article: Effect of desiccation on the dynamics of genome-wide DNA methylation in orthodox seeds of Acer platanoides L[Show abstract] [Hide abstract]
ABSTRACT: Changes in global 5-methylcytosine amount in Acer platanoides seeds were measured.•Viability of A. platanoides seeds was tested by germination and seedling emergence assays.•Desiccation of A. platanoides seeds causes sine wave-like alterations in m5C amount.•Alterations in m5C amount represent a specific response of orthodox seeds to drying.Plant Physiology and Biochemistry 10/2014; DOI:10.1016/j.plaphy.2014.10.014 · 2.35 Impact Factor
Article: Why RNA Biology ?[Show abstract] [Hide abstract]
ABSTRACT: Appreciation is growing for the importance of RNA and its interacting proteins across biology. These molecules function not only in basic cellular processes and the flow of genetic information, but in controlling gene expression, quality control, cell health and development. Yet a full understanding of the signficance of these molecules is only emerging. Genome sequencing has identified numerous RNA-binding proteins whose biological functions are not yet known, as well as many mysterious non-coding RNAs. Importantly, RNA itself is becoming increasingly relevant to disease and its treatment.RNA Biology 10/2014; 1(1):1-1. DOI:10.4161/rna.1.1.1006 · 5.38 Impact Factor
Article: 'Click' chemistry synthesis and capillary electrophoresis study of 1,4-linked 1,2,3-triazole AZT-systemin conjugate[Show abstract] [Hide abstract]
ABSTRACT: The Cu(I) catalyzed Huisgen 1,3-dipolar azide-alkyne cycloaddition (CuAAC) was applied for a nucleoside-peptide bioconjugation. Systemin (Sys), an 18-aa plant signaling peptide naturally produced in response to wounding or pathogen attack, was chemically synthesized as its N-propynoic acid functionalized analog (Prp-Sys) using the SPPS. Next, CuAAC was applied to conjugate Prp-Sys with 3′-azido-2′,3′-dideoxythymidine (AZT), a model cargo molecule. 1,4-Linked 1,2,3-triazole AZT-Sys conjugate was designed to characterize the spreading properties and ability to translocate of cargo molecules of systemin. CuAAC allowed the synthesis of the conjugate in a chemoselective and regioselective manner, with high purity and yield. The presence of Cu(I) ions generated in situ drove the CuAAC reaction to completion within a few minutes without any by-products. Under typical separation conditions of phosphate 'buffer' at low pH and uncoated fused bare-silica capillary, an increasing peak intensity assigned to triazole-linked AZT-Sys conjugate was observed using capillary electrophoresis (CE) during CuAAC. CE analysis showed that systemin peptides are stable in tomato leaf extract for up to a few hours. CE-ESI-MS revealed that the native Sys and its conjugate with AZT are translocated through the tomato stem and can be directly detected in stem exudates. The results show potential application of systemin as a transporter of low molecular weight cargo molecules in tomato plant and of CE method to characterize a behavior of plant peptides and its analogs. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.Journal of Peptide Science 09/2014; 20(9). DOI:10.1002/psc.2653 · 1.86 Impact Factor
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ABSTRACT: Plants respond to environmental changes by modifying gene expression. One of the mechanisms regulating gene expression is methylation of cytosine to 5-methylcytosine (m(5)C) which modulates gene expression by changing chromatin structure. Methylation/demethylation processes affect genes that are controlled upon environmental stresses. Here, on account of the regulatory role of m(5)C, we evaluate the content of m(5)C in DNA from normal and wound-damaged maize leaves. Wounding leads to a transient decrease of the global DNA methylation level ca 20-30% 1 h after the treatment followed by a return to the initial level within the next hours. Similar results were obtained using of radio-labeled nucleotides separated by Thin Layer Chromatography (TLC) or using m(5)C-specific Enzyme-Linked Immunosorbent Assay (ELISA). Wounding induced in maize leaves a two-step oxidative stress, an early one just after wounding and the second two hours later. It coincides with the transient changes of the cytosine methylation level. In the stress-inducible maize calcium-dependent protein kinase ZmCPK11 gene wounding transiently reduced methylation of cytosines 100 and 126 in the first exon.Plant Physiology and Biochemistry 06/2014; 82C:202-208. DOI:10.1016/j.plaphy.2014.06.003 · 2.35 Impact Factor
Article: DNA methylation of Quercus robur L. plumules following cryo-pretreatment and cryopreservation[Show abstract] [Hide abstract]
ABSTRACT: Pedunculate oak (Quercus robur) is an ecologically and economically important forest tree species which produces seeds that are classified as recalcitrant. Thus, cryopreservation of seed meristems is a method for long-term preservation of this germplasm in gene banks. During cryopreservation, many factors, such as desiccation, cryoprotection and cooling/rewarming, can induce stress in the frozen meristems. In this study, in vitro survival and the global DNA methylation level of plumules after cryoprotection, desiccation and cryostorage was evaluated. Results indicated that both desiccation and storage in liquid nitrogen have negligible influence on DNA methylation status of Q. robur plumules. These findings support the cryopreservation of plumules as an appropriate method for conservation of Q. robur germplasm.Plant Cell Tissue and Organ Culture 04/2014; 117(1). DOI:10.1007/s11240-013-0417-9 · 2.61 Impact Factor
Article: Spiegelzymes® Mirror-Image Hammerhead Ribozymes and Mirror-Image DNAzymes, an Alternative to siRNAs and microRNAs to Cleave mRNAs In Vivo?[Show abstract] [Hide abstract]
ABSTRACT: With the discovery of small non-coding RNA (ncRNA) molecules as regulators for cellular processes, it became intriguing to develop technologies by which these regulators can be applied in molecular biology and molecular medicine. The application of ncRNAs has significantly increased our knowledge about the regulation and functions of a number of proteins in the cell. It is surprising that similar successes in applying these small ncRNAs in biotechnology and molecular medicine have so far been very limited. The reasons for these observations may lie in the high complexity in which these RNA regulators function in the cells and problems with their delivery, stability and specificity. Recently, we have described mirror-image hammerhead ribozymes and DNAzymes (Spiegelzymes®) which can sequence-specifically hydrolyse mirror-image nucleic acids, such as our mirror-image aptamers (Spiegelmers) discovered earlier. In this paper, we show for the first time that Spiegelzymes are capable of recognising complementary enantiomeric substrates (D-nucleic acids), and that they efficiently hydrolyse them at submillimolar magnesium concentrations and at physiologically relevant conditions. The Spiegelzymes are very stable in human sera, and do not require any protein factors for their function. They have the additional advantages of being non-toxic and non-immunogenic. The Spiegelzymes can be used for RNA silencing and also as therapeutic and diagnostic tools in medicine. We performed extensive three-dimensional molecular modelling experiments with mirror-image hammerhead ribozymes and DNAzymes interacting with D-RNA targets. We propose a model in which L/D-double helix structures can be formed by natural Watson-Crick base pairs, but where the nucleosides of one of the two strands will occur in an anticlinal conformation. Interestingly enough, the duplexes (L-RNA/D-RNA and L-DNA/D-RNA) in these models can show either right- or left-handedness. This is a very new observation, suggesting that molecular symmetry of enantiomeric nucleic acids is broken down.PLoS ONE 01/2014; 9(1):e86673. DOI:10.1371/journal.pone.0086673 · 3.53 Impact Factor
Article: Global Changes in DNA Methylation in Seeds and Seedlings of Pyrus communis after Seed Desiccation and Storage[Show abstract] [Hide abstract]
ABSTRACT: The effects of storage and deep desiccation on structural changes of DNA in orthodox seeds are poorly characterized. In this study we analyzed the 5-methylcytosine (m(5)C) global content of DNA isolated from seeds of common pear (Pyrus communis L.) that had been subjected to extreme desiccation, and the seedlings derived from these seeds. Germination and seedling emergence tests were applied to determine seed viability after their desiccation. In parallel, analysis of the global content of m(5)C in dried seeds and DNA of seedlings obtained from such seeds was performed with a 2D TLC method. Desiccation of fresh seeds to 5.3% moisture content (mc) resulted in a slight reduction of DNA methylation, whereas severe desiccation down to 2-3% mc increased DNA methylation. Strong desiccation of seeds resulted in the subsequent generation of seedlings of shorter height. A 1-year period of seed storage induced a significant increase in the level of DNA methylation in seeds. It is possible that alterations in the m(5)C content of DNA in strongly desiccated pear seeds reflect a reaction of desiccation-tolerant (orthodox) seeds to severe desiccation. Epigenetic changes were observed not only in severely desiccated seeds but also in 3-month old seedlings obtained from these seeds. With regard to seed storage practices, epigenetic assessment could be used by gene banks for early detection of structural changes in the DNA of stored seeds.PLoS ONE 08/2013; 8(8):e70693. DOI:10.1371/journal.pone.0070693 · 3.53 Impact Factor
Article: Prediction of hammerhead ribozyme intracellular activity with the catalytic core fingerprint.[Show abstract] [Hide abstract]
ABSTRACT: Hammerhead ribozyme is a versatile tool for down-regulation of gene expression in vivo. Due to its small size and high activity, it is used as a model for RNA structure-function relationship studies. Here we describe a new extended hammerhead ribozyme HH-2 with a tertiary stabilizing motif constructed on the basis of the tetraloop receptor sequence. This ribozyme is very active in living cells but shows low activity in vitro. To understand it, we analyzed tertiary structure models of substrate:ribozyme complexes. We calculated six unique catalytic core geometry parameters as distances and angles between particular atoms that we call the ribozyme fingerprint. A flanking sequence and tertiary motif change the geometry of the general base, general acid, nucleophile and the leaving group. We found almost complete correlation between these parameters and the decrease of target gene expression in the cells. The tertiary structure model calculations allow us to predict ribozyme intracellular activity. Our approach could be widely adapted to characterize catalytic properties of other RNAs.Biochemical Journal 02/2013; DOI:10.1042/BJ20121761 · 4.78 Impact Factor
Article: Spiegelzymes: Sequence Specific Hydrolysis of L-RNA with Mirror Image Hammerhead Ribozymes and DNAzymes[Show abstract] [Hide abstract]
ABSTRACT: In this manuscript we describe for the first time mirror image catalytic nucleic acids (Spiegelzymes), which hydrolyze sequence specifically L-ribonucleic acid molecules. The mirror image nucleic acid ribozymes designed are based upon the known hammerhead ribozyme and DNAzyme structures that contain L-ribose or L-deoxyribose instead of the naturally occurring D-ribose or D-deoxyribose, respectively. Both Spiegelzymes show similar hydrolytic activities with the same L-RNA target molecules and they also exhibit extra ordinary stabilities when tested with three different human sera. In this respect they are very similar to Spiegelmers (mirror image aptamers), which we had previously developed and for which it has been shown that they are non-toxic and non-immunogenic. Since we are also able to demonstrate that the hammerhead and DNAzyme Spiegelzymes can also hydrolyze mirror image oligonucleotide sequences, like they occur in Spiegelmers, in vivo, it seems reasonable to assume that Spiegelzymes may in principle be used as an antidote against Spiegelmers. Since the Spiegelzymes contain the same building blocks as the Spiegelmers, it can be expected that they will have similar favorable biological characteristics concerning toxicity and immunogenety. In trying to understand the mechanism of action of the Spiegelzymes described in this study, we have initiated for the first time a model building system with L-nucleic acids. The models for L-hammerhead ribozyme and L-DNAzyme interaction with the same L-RNA target will be presented.PLoS ONE 01/2013; 8(1):e54741. DOI:10.1371/journal.pone.0054741 · 3.53 Impact Factor
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ABSTRACT: One of the key questions of biology is the nature and mechanisms of gene function. It has been 60 years since proposing the right-handed model of DNA double helix in 1953. This discovery was honored with Nobel Prize in 1962 and become a breakthrough in knowing and understanding mechanisms of heredity and genetic code. Since that time a great deal of data have been gathered considering functions, structure and DNA application. It became the basis of modern molecular biology, chemical biology and biotechnology. Today we know, that double helix is characterized by its dynamics and plasticity, which depend on its nucleotide sequence. Chromatin structure and DNA mediated charge transport have a crucial role in understanding mechanisms of its damage and repair. Progress in epigenetics allowed to identify new DNA bases, such as 5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine. Design of new catalytic nucleic acids and the nanotechnology field of DNA origami reveal its application potential.Postepy biochemii 01/2013; 59(3):246-56.
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ABSTRACT: Hammerhead ribozyme is the smallest naturally occurring catalytic RNA. It is a perfect model for structure-function relation studies. Initially, it was identified as an autocatalytic part of viroid and virusoid genomic RNA. It exists within the genomes of many organisms including human, which makes it the most common autocatalytic motif in the nature. After 25 years of intensive research, there are a lot of data considering its structure, conformational dynamics and an influence of tertiary stabilizing motifs on its stability and properties. Structure of the hammerhead ribozyme is a system of elements that influence each other. The knowledge of ribozyme architecture is outstandingly interesting in the context of rules and logic of design, construction and application of such molecules as spatial molecular constructions. Presence of additional structural motifs distinguishes extended hammerhead ribozyme from the minimal one. Hammerhead ribozyme recognizes complementary RNA and catalyses transesterification after the 5'-NUH-3' sequence. Reaction efficiency depends on an arrangement of atoms of the catalytic core presence of metal ions and other intracellular factors. Innovative and potentially better derivatives of the hammerhead ribozyme are objects of extensive research in the field of molecular medicine.Postepy biochemii 01/2013; 59(1):22-32.
Article: Convenient and Efficient Syntheses of N (6)- and N (4)- Substituted Adenines and Cytosines and their 2'-Deoxyribosides.[Show abstract] [Hide abstract]
ABSTRACT: Convenient and efficient methods of the synthesis of N(6)- and N(4)-substituted derivatives of adenine and cytosine and their 2'-deoxyribosides were developed. The reactions of either unprotected nucleobases (adenine, cytosine) or unprotected 2'-deoxyribosides with aryl or alkyl aldehydes give corresponding Schiff bases that can be reduced to the target title compounds with high overall yields. In the case of aryl aldehydes the imine derivatives are obtained in the presence of methoxides in methanol and reduced with sodium borohydride. The corresponding reactions with alkyl aldehydes require the use of acetic acid and borane dimethyl sulfide complex instead.Nucleosides Nucleotides & Nucleic Acids 12/2012; 31(12):861-871. DOI:10.1080/15257770.2012.742198 · 0.89 Impact Factor
Article: Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to evaluate the effect of phloretamide (PA), an apple constituent, on the activation of the Nrf2 transcription factor and the expression of its target genes: glutathione S-transferases (GSTs), NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase-1 (HO-1) in normal human THLE-2 hepatocytes and the hepatoma HepG2 cell line. PA did not show significant cytotoxicity towards THLE-2 cells but such an effect was observed in HepG2 cells (IC(50) ∼200μM). The treatment of cells with PA resulted in the translocation of Nrf2 from cytosol to nucleus in both cell lines, but increased the level of its transcript and protein only in THLE-2 cells. In this cell line an increased level of GSTA, GSTP, GSTT, NQO1 mRNA was also observed. Increased expression of GSTs was confirmed by enhancement of their protein levels. The increase in p53 protein content observed in THLE-2 may be associated with its stabilization induced by the enhancement of NQO1 level. PA did not affect Nrf2, GSTs, NQO1 or HO-1 expression in HepG2 cells. These results suggest that PA has rather chemopreventive than chemiotherapeutic potential and acts similarly as apple dihydrochalcones through the induction of detoxification/antioxidative enzymes.Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 10/2012; 51. DOI:10.1016/j.fct.2012.09.033 · 2.61 Impact Factor
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ABSTRACT: DNA cytosine methylation catalyzed by DNA methyltransferase 1 (DNMT1) is an epigenetic method of gene expression regulation and development. Changes in methylation pattern lead to carcinogenesis. Inhibition of DNMT1 activity could be a good strategy of safe and efficient epigenetic therapy. In this work, we present a novel group of cytosine analogs as inhibitors of DNA methylation. We show new methods of synthesis and their effect on in vitro reaction of DNA methylation. Almost all of analyzed compounds inhibit DNA methyltransferase activity in the competitive manner. K(i) values for the most potent compound 4-N-furfuryl-5,6-dihydroazacytosines is 0.7 μM. These compounds cause also a decrease of 5-methylcytosine (m(5)C) level in DNA of mammalian HeLa and HEK293 cells.European Journal of Medicinal Chemistry 07/2012; 55:243-54. DOI:10.1016/j.ejmech.2012.07.024 · 3.43 Impact Factor
- ChemInform 02/2012; 43(8). DOI:10.1002/chin.201208269
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ABSTRACT: The tertiary structure of nucleic acids results from an equilibrium between electrostatic interactions of phosphates, stacking interactions of bases, hydrogen bonds between polar atoms and water molecules. Water interactions with ribonucleic acid play a key role in its structure formation, stabilization and dynamics. We used high hydrostatic pressure and osmotic pressure to analyze changes in RNA hydration. We analyzed the lead catalyzed hydrolysis of tRNAPhe from S. cerevisiae as well as hydrolytic activity of leadzyme. Pb(II) induced hydrolysis of the single phosphodiester bond in tRNAPhe is accompanied by release of 98 water molecules, while other molecule, leadzyme releases 86.Molecular Biology Reports 02/2012; 39(5):6309-18. DOI:10.1007/s11033-012-1452-z · 1.96 Impact Factor
Top Journals
Institute of Bioorganic Chemistry Polish Academy of SciencePosen, Greater Poland Voivodeship, Poland
Polish Academy of Sciences
Cracovia, Lesser Poland Voivodeship, Poland
- Institute of Organic Chemistry
Instytut Historii Polskiej Akademii NaukPosen, Greater Poland Voivodeship, Poland
Instytut Matki i DzieckaWarszawa, Masovian Voivodeship, Poland
BioInfoBank InstitutePosen, Greater Poland Voivodeship, Poland
Społeczna Akademia NaukWarszawa, Masovian Voivodeship, Poland
Gdansk University of TechnologyDanzig, Pomeranian Voivodeship, Poland
Freie Universität Berlin
Berlin, Land Berlin, Germany
- Institute of Chemistry and Biochemistry
Medical University of Gdansk
Gdańsk, Pomeranian Voivodeship, Poland
- Department of Pharmacology
Poznan University of Medical Sciences
Posen, Greater Poland Voivodeship, Poland
- Department of Neurosurgery and Neurotraumatology
Hebrew University of Jerusalem
Yerushalayim, Jerusalem, Israel
- Department of Biological Chemistry
University of Gdansk
Danzig, Pomeranian Voivodeship, Poland
- Faculty of Chemistry
Instytut Chemii Fizycznej PANWarszawa, Masovian Voivodeship, Poland
Aarhus University
Aars, Region North Jutland, Denmark
- Department of Chemistry
Yale University
New Haven, Connecticut, United States
- Department of Molecular Biophysics and Biochemistry
Adam Mickiewicz UniversityPosen, Greater Poland Voivodeship, Poland
University of ZurichZürich, Zurich, Switzerland


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69 year old man | New York, NY, USA | Seeking women 55-68 within 10 miles
My name is John. I am English, born in London....
My name is John. I am English, born in London. I came to the USA several years ago and I eventually moved to Manhattan. Since 1994 I have lived in the heart of Greenwich Village, eventually moving to a co-op on Bedford Street and Barrow, a magical, charming and historic section of Manhattan's West Village. I like to walk and sit by the Hudson River here in Greenwich Village. I have no interest in Conservatives or Republicans. My job has taken me to so many places, including visits to Mexico, Puerto Rico, France. Germany, Holland, China, Hawaii, Hong Kong and Tokyo. I particularly loved Monaco, Paris, Hong Kong and Old San Juan. I have remained in Manhattan mainly to be able to attend the ballet, classical concerts and piano recitals as music has always been one of the best antidotes to life's problems. Also, the fine choice of Independent films and theater here in Manhattan. I have a car garaged here in Manhattan. I grew up in London; those were very happy days. I have always regretted leaving England. I feel as if I had deserted a simple way of life, and the very small family we had. There are I believe many of my generation felt very fortunate to be British. My father lived to be 101 years old, born in the Old Street area of London, he never left England. He was a brilliant commercial photographer, totally honest, unassuming and the hardest working man I have ever known. My mother, a fine pianist and soprano loved the songs of Ivor Novello. Sometimes it has little to do with how much you might love someone, maybe it is more important who you are when you are with them. When people show you who they are, we should believe them, the first time. To fall in love, even if only on one occasion, colours the rest of one's life. They say that at least once in every lifetime, someone comes along. I remember that wonderful feeling of being in love. Telephone calls and endless emails often lead nowhere. To actually meet one another is far more telling...and wonderful to anticipate a possible loving connection.
Coffee and conversation , Dining out , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Travel/Sightseeing , Wine tasting
Dancing, Tennis / Racquet sports, Walking / Hiking
I exercise 3-4 times per week.
I like Cats, Dogs, Horses
Hong Kong, Paris, Old San Juan, San Francisco: Tadich Grill, Toronto: Fune, Maui, London, Manhattan: Aquagrill, Union Square Greenmarket.
Max von Sydow, Juliette Binoche, Virginia Madsen, Joaquin Phoenix, Sally Hawkins, Bill Nighy, Emily Watson,The Knick, Clive Owen, Vera Farmiga, Amy Ryan, Joan Allen, Lena Olin, Marisa Tomei, Marthe Keller, Charlie Rose, Wine, Violets, Sashimi, love..
Ballet: ABT: Manon and Giselle with Vishneva/Gomes, Hee Seo. NYC Ballet: Balanchine's "Agon", Piano Recitals: Yuja Wang, Murray Perahia, Classical music, True Detective, Homeland, PBS, TCM, Lost in Translation, The Upside of Anger, Green Card.
New York Times, The Telegraph, The Guardian, Urban Dictionary...Wine labels.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|6'1" (185cms)
|5'4" (162cms) to 5'10" (177cms)
|Body type:
|Slender, About average, Curvy, Athletic and toned
|Black, Blue, Brown, Grey, Green, Hazel
|Salt and pepper
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Salt and pepper, Dark blonde, Grey
|No Way
|No Way
|Social Drinker
|Social Drinker, Moderately
|Administrative / Secretarial, Artistic / Creative / Performance, Medical / Dental / Veterinary / Fitness, Retail / Food services, Retired, Sales / Marketing, Education / Teacher / Professor, Travel / Hospitality / Transportation, Fashion / Model / Beauty
|$35,001 to $50,000, $50,001 to $75,000, $75,001 to $100,000
|Widow / Widower, Divorced
|Have kids:
|Yes, and they live away from home (2)
|No, Yes, and they live away from home
|Wants kids:
|No, No, but it's OK if my partner has kids
|White / Caucasian
|Asian, Black / African descent, Latino / Hispanic, Native American, White / Caucasian
|Christian / Protestant
|Agnostic, Christian / Catholic, Christian / Protestant, Jewish, Spiritual but not religious
I sometimes attend an Episcopal service here in Manhattan.
|Some college
|Some college, Bachelors degree, Graduate degree


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Posted On: 17 Oct 2012 - 11:27am
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I have a strong background in photographing electronic music events. I recently moved here from Ohio so I'm still learning the area and looking forward to discovering what the Louisville music scene holds!More from author:
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Originally written on Fox Sports | Last updated 8/25/13
Michael Vick took off running way more than the Philadelphia Eagles would like Saturday night.` He also threw an interception while trying to get rid of the ball. It wasn't his best performance of the preseason. But it wasn't cause for alarm, either, coach Chip Kelly said following his team's 31-24 victory over the Jacksonville Jaguars. ''Hopefully we get that stuff out of us,'' Kelly said. ''I thought Michael did a really good job of keeping plays alive at times, but there are other times where you have to cut your losses and get us back to the line of scrimmage and get the next snap off. He did a good job of not forcing the football.'' Vick completed 15 of 23 passes for 184 yards, with a touchdown and an interception. He also ran seven times for 53 yards, most of them coming after plays broke down. Just days after being chosen the starter, Vick showed solid command of Kelly's up-tempo offense. ''I think there were a lot of things that happened tonight that are very promising...
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Trends of consanguineous marriages in a Sunni Muslim population of West Bengal, India.
ABSTRACT The Muslim population of the Chaltaberia village in the district of South 24 Parganas in West Bengal is divided into several wards (paras) inhabited by people of specific surnames. The frequency of endogamous marriages within surnames is greater than randomly expected ones. An incomplete reproductive isolation is observed among the five dominant surnames. Consanguineous marriages occur more often outside the village than inside. Leaving out marriages between long distances, a small median distance of 6.36 km is recorded. The neighborhood area works up to be 552.2 km2, which is rather small. There is an underlying process of breeding isolation by distance. A generation length of 21 years has been used for examining the temporal change in consanguineous marriages and inbreeding, which generally appears to increase. There is a general trend of decline in consanguineous marriages towards the southern part of West Bengal and eastern part of Assam among the Bengalee Muslims. The frequency of consanguineous marriages is 7.3% out of all marriages (N=1153) that have taken place in six generations in the population. The first cousin marriage is nearly 50% of all marriages. Patrilineal marriages are common in marriages between second and third cousins. An increase of consanguineous marriages in the younger generation was observed, but the total frequency agrees with a general trend of a decline in the frequency of consanguineous marriages among the Muslims in this part of India.
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- SourceAvailable from: Solaf Mohamed Elsayed[Show abstract] [Hide abstract]
ABSTRACT: Consanguinity is the blood relationship that exists among individuals that descend from a common ancestor. The objectives of the study was to explore the frequency and socio-economic determinants of consanguinity in Egypt. The study was carried out using a cross-sectional approach which included 10,000 unselected couples. All couples were recruited from the prenatal, gynecologic, neonatal and pediatric clinics as well as vaccination centers in three hospitals one in Lower Egypt (Cairo) and two in Upper Egypt (Sohag and Assuit).Consanguineous marriage is still high in Egypt (35.3%), especially among first cousins (86%). However the frequency varies by region. It is higher in Sohag (42.2%) and Cairo (36.1%) than in Assuit (21.7%). Also it was higher in rural areas (59.9%) than in semi-urban and urban areas (23.5% and 17.7%, respectively). It was associated with decreased age of marriage, low educational level and unemployment in the couples which means that the socio-economic determinants are still working in maintaining this high rate of consanguinity. This is in addition to the high divorce rate and increased number of unmarried females in Egypt.Advances in genetics have led to a deeper understanding of the effect of inbreeding on the occurrence of genetic diseases. As prolonged parental inbreeding has led to a background of homozygosity above that predicted by simple models of consanguinity, we encourage counselors to call on a reliable computer program for calculation of the recurrence risks in these families.World Pumps 11/2011; 12(2). DOI:10.1016/j.ejmhg.2011.07.001
Article: Does maternal Helicobacter pylori infection increase the risk of occurrence of neural tube defects in newborns in Northern Iran?[Show abstract] [Hide abstract]
ABSTRACT: To determine the relation between maternal Helicobacter pylori (H. pylori) infection and the occurrence of neural tube defects (NTDs) in newborns. This hospital-based case-control study was carried out in Dezyani Teaching Hospital, Gorgan, Northern Iran from April 2007 to March 2009. Thirty-five mothers with NTD-affected newborns, and 53 mothers with healthy newborns were considered the cases and controls. A peripheral blood sample was obtained from all subjects, and H. pylori infections were tested by H. pylori serum antibody. The serum folic acid, vitamin B12, ferritin, and homocysteine concentrations were measured by laboratory tests. Data were analyzed using odds ratio (OR) and logistic regression. Forty-three percent of cases, and 26% of controls were positive for H. pylori IgG antibody, and this difference was not significant. The H. pylori seropositivity non significantly increased the risk of NTD-affected pregnancies (OR: 2.08; 95% confidence interval [CI]: 0.84-5.17, p=0.11). Serum vitamin B12 deficiency was detected in 17% of cases and 13% of controls, and folic acid deficiency in 17% of cases and 13% of controls (p=0.61). The H. pylori seropositivity was non significantly associated with low serum folate (OR 1.93 CI: 0.58-6.4, p=0.34) and ferritin (OR 1.24; CI: 0.42-3.60, p=0.68). Maternal H. pylori infection can increase the risk of occurrence of NTDs in newborns.Neurosciences 07/2012; 17(3):219-25. · 0.39 Impact Factor


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The Goblin Shark [Pix]
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Seeing how it is shark week and from multiple requests, I picked the Goblin shark as today's ocean terror.
What is this monster...
This real life monster is known as the Goblin Shark, or scientifically the Mitsukurina owstoni. This species of shark is one of the rarest in the modern world, its kind have a traceable linage that is roughly 125 Million years. This shark is also solemnly seen as it avoids sunlight and hunts in the deepest and darkest of oceans. Because of its habitat it is rarely caught on film.
What does it look like?
The adult Goblin shark is estimated to measure between 3 and 4 m (10 and 13 ft) long. However, a female was caught estimated at 5.46.2 m (1820 ft) long showing that this species can grow far larger than previously thought. For comparison... that's the size of an adult killer whale... wonder who would win in that fight... Now what makes this creature of the dark so interesting to me personally is its skin and of course that infamous jaw. Its skin range from pinkish gray to bubblegum pink! Now that isn't even the interesting part, whats amazing is that their skin is transparent. Yep you can see through its skin, not completely, but enough to see blood flowing through its veins. Very freaky!
A natural blade
Its nose, or snout is shaped like a sharpened sword. It is believed that it uses this blade to defend itself and sometimes attack prey. Mostly though they use it by digging up prey located in the muddy ocean bottom. The nose also has special sensory organs that help these sharks detect electric fields in the water that its prey produces.
The Jaw
The sharks jaw moves exactly like a human can move its tongue. The jaw protrudes out and snaps at the prey, the jaw can reach up to the length of its nose. The reason for the unique jaw is because the shark moves very slow and is not a fast swimmer so it uses ambushes to kill. When prey swims by, SNAP its attacks and kills the prey.
The Teeth
With 3553 upper and 3162 lower teeth rows, this shark has some cutting power, the rear teeth are more flat and are designed to crush its prey while the front are to trap and pierce it.
What does it hunt.
Being an ambush predator this creature often waits for its victims. Some prey it enjoys to snack on are fish, sting rays, mollusks, and crabs. In some circumstances they are also able to eat squid. They do feed quite often which is interesting. The goblin shark has a very large liver which is usually found in sharks that dont eat very often. This has yet to be discovered for why it has an unusual large liver. But don't worry there is no reports of humans being eaten.. well other than this diver's arm in the gif... but you're safe... for the most part.
Where do they lurk
They tend to thrive in lakes or ponds that have lots of tourists... just kidding... they like to live deep in the ocean with little sunlight. The majority of them are found near japan and sometimes are caught, mostly by accident. They have been caught in all 3 of the major oceans and are found over the upper continental slope at depths of 270960 m (8903,150 ft). It has been caught as deep as 1,300 m (4,300 ft) but have been seen wandering into inshore waters as shallow as 40 m (130 ft). In April 2014, fishermen in Key West, Florida, while fishing in the Gulf of Mexico caught a goblin shark in their fishing net, only the second one ever to be caught in the Gulf.
Thanks for reading!!!!
A nice article about a very rare shark. Posted for Shark Week.
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The Goblin Shark [Pix]. A nice article about a very rare shark. Posted for Shark Week.
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Male, 18-29, Eastern US
257 Posts
Friday, August 15, 2014 12:44:00 PM
A cool post that was well thought out and has a bunch of awesome pictures? Hmmm better point out the one typo...
Male, 40-49, Western US
1214 Posts
Thursday, August 14, 2014 11:12:41 AM
Yeah, the 1820ft thing is a typo. Blue whales only get to about 100 feet and they are considered the largest animals to ever inhabit the earth.
says that female was between 18-20 ft long.
Male, 18-29, Canada
1263 Posts
Thursday, August 14, 2014 9:53:20 AM
might wanna proofread that poo, 1820ft, roughly 607 yards... over 6 football fields in length? i think that might be the largest animal to have ever existed
Male, 50-59, Europe
5843 Posts
Thursday, August 14, 2014 9:28:50 AM
'The adult Goblin shark is estimated to measure between 3 and 4 m (10 and 13 ft) long. However, a female was caught estimated at 5.46.2 m (1820 ft) long showing that this species can grow far larger than previously thought.`
1820 ft. wow!
Male, 40-49, Eastern US
579 Posts
Thursday, August 14, 2014 12:22:41 AM
The Goblin Shark [Pix]
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- A nice article about a very rare shark. Posted for Shark Week.
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6000-Year-Old Skeleton Shows Woman Was Buried Pregnant in Bulgaria
Bulgarian archaeologists have uncovered the remains of a woman that appears to have been buried pregnant 6000 years ago.
The found – described as highly unusual - was made in a newly discovered necropolis in the famous village of Svestari in north-east Bulgaria.
A total of five skeletons were discovered in the necropolis, all of them buried in unusual position – with their legs bound and their heads facing southwards, the BGNES news agency informs.
The buried woman had exquisite pearl ornaments, according to Professor Diana Gergova, who led the dig.
In September, Gergova's team found in Sveshtari the remains of a 2500-year-old Thracian carriage and two horses that appear to have been buried upright.
A unique gold Thracian treasure was discovered in Sveshtari in 2012.
Located in north-eastern Bulgaria, Razgrad region, the Sveshtari site, also known as Sboryanovo, hosts a great many remains of the Getae, a Thracian tribe whose major city of Helis is also thought to have been located nearby. -
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