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100 years of Spooks, Fantasy and Adventure! From the Midways to Disneyland! This is the little known and highly entertaining story of the amusement rides that everybody loves but knows nothing about.... More > It's for those who ride, will ride, can't ride or are too afraid to ride! The ONLY book ever written that turns the lights on! A very personal tour you'll enjoy reading. Rick West, Theme Park Adventure Magazine: "Scary Dark Rides is the essential piece of any enthusiasts personal library and a MUST HAVE for Theme Park fans of all ages around the world." Top WDI (Disneyland) Imagineer, Tony Baxter says: "What can I say but thanks so much...made me think about my best experiences with dark rides!" Haunted Attraction Magazine: "...a gem of a book! Imagine a chat on the porch with a favorite uncle, you learn some simple truths. Terrific stuff!" Columnist for MiceAge.com, KEVIN YEE writes: "I read it right away! It's a fun book, a great read for anyone even mildly interested in dark rides."< Less
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text: community-nbc By June 6, 2013 10:11 PM Share on Facebook Share on Twitter Category: Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of WNBF B-Mets Send Four to All-Star Game Fire-Wrecked Binghamton Building to Be Rebuilt Chris Thater Registration Opens Two Endwell Men Charged After Sexual Assault Recommended For You Best of the Web


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I am going Contiki!
Canada & the Rockies plus Calgary Stampede
6 days to go
Emily EmilyFollow Emily
23-year-old Female living in Glenfield, NSW Australia
Level 2 Traveler
2 tours
17 countries
Following 3 people
Followed by 6 people
Upcoming Contikis
Trips I've Done
Wild Western
1 country \ 14 days \ from US$2299 per person
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European Explorer plus Greek Island Cruising
16 countries \ 34 days \ from US$6439 per person
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Favorite Tours
Grand Canadian plus Calgary Stampede
2 countries \ 22 days \ from n/a per person
From big city buzz to the great outdoors, it's all here. Start off by exploring Boston & New York in the US before diving into Canada. Cross the border into quaint Quebec then spend a few nights in Montreal & Toronto. After the city action, fly west for a dose of coastal charm & natural wonders, including the Rockies & Vancouver's cool vibe. And then on top of all of that, hit up the world famo...
Places I've Been (?)
- Albania
- Austria
- Croatia
- England
- France
- Germany
- Greece
- Holy See (Vatican City State)
- Italy
- Liechtenstein
- Monaco
- Netherlands
- Spain
- Switzerland
- Turkey
- United Kingdom
- United States
Places I'd Like to Visit
- Canada
- United States


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Book your room at Georgian and Bower House Hotel
Get an overview of this hotelFamily-friendly London guesthouse in Victoria, near Big Ben
A family-friendly stay in the heart of London awaits you at Georgian and Bower House Hotel. Within a 20-minute stroll, you'll find popular places like Victoria Palace Theatre, Sloane Square, and Saatchi Gallery. Highlights at this guest house include free in-room WiFi.
You can enjoy flat-screen TVs with digital channels, and all 62 rooms feature coffee/tea makers, safes, and hair dryers.
At the guest house's own bar/lounge, you can stop for a drink. Added amenities include free WiFi in public areas, a 24-hour front desk, and express check-out. Each morning English breakfast is served between 8 AM and 10:30 AM.
Within a 30-minute walk of this 4-star Victoria guest house, attractions include Buckingham Palace and Big Ben.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Georgian and Bower House Hotel features multilingual staff and express check-out. High-speed wireless Internet access is complimentary. A bar/lounge is on site where guests can unwind with a drink.
Georgian and Bower House Hotel is a smoke-free property.
- Breakfast available (surcharge)
- Bar/lounge
- Multilingual staff
- 24-hour front desk
- Express check-out
- Babysitting or childcare
- Total number of rooms - 62
- Luggage storage
- Number of floors - 6
- Smoke-free property
- Free WiFi
- Year Built 1851
- Number of buildings/towers - 2
Family Friendly Amenities
- Family Hotel
- Free Wi-Fi
- Rollaway/extra beds available
- Babysitting or childcare
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Room Amenities
- Coffee/tea maker
- Daily housekeeping
- Hair dryer
- Iron/ironing board (on request)
- Rollaway/extra beds available
- Cribs/infant beds available
- Digital TV service
- Flat-panel TV
- Free WiFi
- In-room safe
Where to Eat
English breakfasts are available for a surcharge and are served each morning between 8 AM and 10:30 AM.
Hotel Policies
Check-in time starts at 2:00 PM
Check-out time is 11:00 AM
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- No onsite parking is available.
No elevators
- Fee for English breakfast: GBP 14.95 for adults and GBP 4.99 for children (approximately)
We should mention
Children 5 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.


text:
< Return to Product Page
Customer Reviews
Flexi Ties
Overall Rating:
Customer Reviews
Flexi Ties 8 8
Flexi Ties I have a drawer of cords (mostly computer-related) that I was trying to get under control. Flexi Ties are pretty, but when I purchased them, I didn't think about how much space they would take up compared to Velcro cable ties. The Flexi Ties almost double the storage space needed for some of the smaller cables, which is something I am concerned with in a small apartment. This product is okay and I will continue to use it, but I think I would have been better off with something different. April 28, 2013
MUST HAVE! GOT CORDS? My home office was crazy with cords: the computer, the server, the monitor, the printer. And when extension cords were stored, it was always a tangled bundle to find one when needed. The FLEXI TIE is my new best friend! Now I have conquered the cords and have a neat, organized starage of cords when not in use. Cords and cables for the office are neatly wrapped and secured. No zip-ties or little clips to manage---just unwrap and rewrap to change or re-position cords as needed. The available colors make it easy to identify cords as well. NO MORE CORD CHAOS! YOU MUST HAVE THIS PRODUCT! April 16, 2013
Fun and Practical Flexi Ties These are a fun yet practical way to keep my cords secure, and they're easy to use. I purchased the pink/yellow/blue set for me and the black/white set for my husband. Now our corded bathroom styling tools are neat and secure. January 28, 2013
Very helpful in the garage Love this for cords in the garage. Wish it were a little longer to use for longer utility cords. April 27, 2012
Colorful & useful GReat item - useful, fun, colorful. A bit too pricey April 9, 2012
Excellent gadget This is the easiest gadget i bought to organize my cords. I use it for my cords from my flat iron and hair dryer. I save the blue ones for my husband to use on his computer cords or chargers. We love them. I can twist to tie cords together and undo them in seconds. Before I normally just loosely wrapped the cords around the dryer which gets all tangled up in the end and more work to undo them. With this tie, it just made my life easier and more organized. One suggestion would be I hope they can come up with longer ties for my bigger cords. For now... I try to bundle the cords in a longer bundle so its smaller to tie around or I twist two ties together for a longer tie. March 21, 2012
Flexi Ties I bought these a couple of years ago and they are still holding up very well! I think maybe the ones I have are heartier than the new ones since the last review was not favorable. But I use them over and over again and they hold even the thicker cords very well. March 20, 2012
Not worth it For the price, I expected a better product - these take a bit of work to make them hold . . . kind of flimsy. Would have returned them, but didn't want to deal with it. February 29, 2012
1-8 of 8


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The Top 10 In Action Sports
01Sam Pilgrim vs. The World: The Champion Aiming To Reclaim His Crown In A New Era Of Biking
02Eccentric Adventures Episode 2: Britain's Most Brutal Illegal Event is All About Cheese
03A Journey Into Darkness: We Went Mountain Biking in the Abandoned Mines of Slovenia
04Watch The Battle at the Berrics 2015 Finals Live Stream
05Debate: Let's Stop Hating On Parents Who Want To Raise Adventurous Kids
06Guns, Roses, And Eating Insects: Adventure Cycling in Vietnam
07Big Air Will Be In The 2018 Olympics Which Is Good News For Team GB
08From Intense Trails to Intensive Care: Dicing with Death In a Mountain Biking Paradise
09Lifting The Veil: The Truth About Women's Snowboarding In Iran
10Cool Runnings: Is Jamaica Mountain Biking's Best Kept Secret?
SLV - Episode 14
A Snowboarding video by fearofthepark - 4,026 views
Shred lies and videotape - Episode 14.
Only one episode for April this year, but it's a banger again. Plenty of action from around the UK scene.
You like it, You love it, YOU NEED IT!
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text:
Mary Cox
Original recipe yields 4 servings
Amount per serving ({{servings}} total)
Based on a 2,000 calorie diet
Ready In
So, I adjusted this recipe just a touch, just so I could cook the majority of this in my crockpot and make it a little heartier/ make it really stretch. I doubled this recipe so that we could ha...
I used leftover turkey with this recipe. I was really easy and tasted pretty darn good.
The pearl onions are a nice touch of unexpected sweetness!


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GQ's digital edition designed specially for your device
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Hi, I'm a 16 going on 17 year old guy in secondary school, and spend a large percentage of my free time, thinking of how I can make my school uniform look better, and make eyes roll when I walk into school. Of course, being the age I am, my budget is not quite up to that of GQ. So, at the moment I wear a white/ grey slim fit shirt, usually from Zara and black Reiss skinny trousers to school. I am looking for any accessories and a winter coat, preferably a Crombie style one, that would help to spruce up my look.
Hi im attending a function to celebrate 10 years that my companys benn in there new location, its a three course meal in a good restaurant. The theme for the night is las vegas casino.Im thinkiung of getting suit below is it to much?http://www.next.co.uk/shopping/men/tailoring/2/1 Also what shirt should i go for and tie or bow tie? I own may shirt from large collars to small , i also have rounded,tad and collar bar ones which should i chose. Your advice is greatfully recived many thanks brendon
Hi there, can one get away with wearing a watch with a black strap with brown shoes and vice versa ? I have three watches and my 'default' is my Rolex Submariner with a chrome strap which I guess goes with anything, but would like to know what the etiquette is regarding matching / non matching leather colours. Regards, Tim
Dear Style Shrink, I am looking for a new coat for winter, something smart casual, as I am only a student, and need something to wear around campus etc. I have looked everywhere but can't seem to find anything that really grabs me. As I am a student, it would also have to be something to match my budget. Many Thanks.
Hey, I am a 16 year old boy who is very style conscious. Most "kids" these days are into Abercrombie & Fitch and Holister brands but I'm looking for a more mature, classy and gentlemanly look. GQ has got a lot of young followers like myself who can also benefit from theis advice.What kind of style and brand do you recommend? Nothing too noisy or formal but something you can wear out and look classy and mature.


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The Global FlyFisher - The Largest and Best Place to go for Online Fly Fishing and Fly Tying
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San Martín de los Andes, provincia de Neuquen. Patagonia Argentina
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Fishing with friendsTravis Swartz spends a lot of time on the water alone, but this past weekend he spent a couple days on the Big Wood River in Ketchum, Idaho fishing with his friends Reese, John and Zach.
July 11th 2012


text:
Adds a new type of feed you can subscribe to. http://example.com/feed/json or http://example.com/?feed=json to anywhere you get a JSON form.
feed-json folder to the
/wp-content/plugins/ directory.
Requires: 3.0 or higher
Compatible up to: 3.9.6
Last Updated: 2014-4-28
Active Installs: 2,000+
0 of 1 support threads in the last two months have been resolved.
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Hunting Show Too 'Politically Incorrect' For Canadian TVSun 3:50am By AWR HawkinsCanada in the Rough airs in 27 countries but can't find a television station or broadcaster willing to air it in Canada. The post Hunting Show Too 'Politically Incorrect' For Canadian TV appeared first on Breitbart.
Women's World Cup Final Features Japan-U.S. Rematch GrudgematchSun 3:39am By Daniel ZimnikovAfter losing a heartbreaker to Japan four years ago in Germany, the U.S. side looks to avenge their penalty shootout defeat and reclaim the #1 world ranking in today's World Cup Final.…
On his native turf, Pope Francis touches on cherished issuesDec 2, 2001, 7:00 pm By APQUITO, Ecuador (AP) — History's first Latin American pope returns to Spanish-speaking South America for the first time on Sunday, bringing a message of solidarity with the region's poor, who are expected to turn out in droves to welcome their…
The Latest: Greek PM: Greeks must choose their own futureDec 2, 2001, 7:00 pm By APATHENS, Greece (AP) — The latest from the referendum in Greece (all times local): ___ 11:40 a.m. Greece's prime minister says the country's austerity referendum is sending the message that Greeks are embracing a united Europe but want to live…
The Latest: Pope Francis leaves for Ecuador on 3-nation tripDec 2, 2001, 7:00 pm By APROME (AP) — Here are the latest developments from Pope Francis' trip to South America: ___ 9:30 a.m. Pope Francis is in the air, heading to his native continent of South America on a nine-day pastoral pilgrimage. The Alitalia plane…
The Latest: Greek vote causes deep divisions in familiesDec 2, 2001, 7:00 pm By APATHENS, Greece (AP) — The latest from the referendum in Greece (all times local): ___ 10:25 a.m. The Greek referendum on whether or not to accept bailout demands by creditors is causing deep divisions, even among individual families. Dimitris Danikoglous…
UPI Almanac for Sunday, July 5, 2015Dec 2, 2001, 7:00 pm By UPIToday is Sunday, July 5, the 186th day of 2015 with 179 to follow. The moon is waning. Morning stars are Mars, Mercury, Nepune and Uranus. Evening stars are Jupiter, Saturn and Venus. Those born on this date are under…
320-acre wildfire threatens homes in Northern CaliforniaDec 2, 2001, 7:00 pm By APVACAVILLE, Calif. (AP) — A wildfire that has burned more than 320 acres is threatening homes in a Northern California city. KCRA-TV reports (http://apne.ws/1fd1gw5 ) that about 100 people have been evacuated in Vacaville. The grass fire started around 10…
Pope leaves for Ecuador on 3-nation trip to South AmericaDec 2, 2001, 7:00 pm By APROME (AP) — Here are the latest developments from Pope Francis' trip to South America: ___ 9:30 a.m. Pope Francis is in the air, heading to his native continent of South America on a nine-day pastoral pilgrimage. The Alitalia plane…
Utility drones could inspect equipment, scan for outagesDec 2, 2001, 7:00 pm By APLITHONIA, Ga. (AP) — When tornadoes and hurricanes topple power lines in the future, flying drones might be the first to pinpoint the damage. Power companies across the United States are testing whether small drones can spot trouble on transmission…
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A classical garden plan tinted a rich blue hue gets an extra-luxe touch from glimmering gold leaf. Printed on archival paper, the work is floated on oyster linen and finished with a wood frame in a rich ebony hue.


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725 South Lincoln, Steamboat Springs, CO, 80488, United States of America, 855-238-1591
Hampton Inn and Suites Steamboat Springs, Steamboat Springs ski area
Lowest price$152
available on 07/11/15
Best Price Guarantee
Ski hotel with free ski shuttle, near Steamboat Ski Resort
- Free hot/cold buffet breakfast, free WiFi, and free parking
- Airport within 5 mi/8 km: Steamboat Springs, CO (SBS)
Main amenities
- 73 guestrooms
- Outdoor pool and 3 spa tubs
- Free ski shuttle
- Ski storage
- Fitness center
- 24-hour business center
- 24-hour front desk
- Coffee/tea in the lobby
- Air conditioning
- Daily housekeeping
- Lobby fireplace
- Front desk safe
What's around
- Steamboat Ski Resort (1.9 mi / 3 km)
- Old Town Hot Springs (0.7 mi / 1.2 km)
- Steamboat Springs Alpine Slide (1.1 mi / 1.7 km)
- Steamboat Art Museum (1.2 mi / 1.9 km)
- The Chief Theater (1.2 mi / 1.9 km)
Very clean, very friendly service. Well stay again.
We chose the king size bed with fireplace room. The fireplace was a cute gas fireplace in…
TripAdvisor Traveller Rating: 4.5
From 491 reviews
Enter dates to check prices
Hotel Info: 866-539-8117from $152
- Room, 1 Queen Bed, Non Smoking, Fireplace
- Room, Accessible
- Two Queen Beds, Non-Smoking
- One King Bed, Non-Smoking
- One King Bed, Non-Smoking
- King bed
- Studio, One King and One Sofa Bed, Non-Smoking
- One King Bed, Non-Smoking, with Fireplace
- Suite, One King Bed, Non-Smoking
- Family Suite, Two King Beds, Non-Smoking
- Suite, Non Smoking
- King studio sofabed
- King with fireplace
- Suite, 2 Queen Beds, Accessible, Non Smoking
- Room, Accessible, Non Smoking
- Two king family suite with sofabed
- Suite, 2 Queen Beds, Non Smoking
- Two queens
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 73 rooms
- This hotel is arranged over 3 floors
- Check-in time starts at 4:30 PM
- Check-out time is 11 AM
- Express check-in/out
Required at check in
- Credit card deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Children (18 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Pets not allowed
Extra people
- Roll-away beds available, charges may apply*
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
- Accessible parking
- Free ski shuttle
Nearby Two Star Steamboat Springs ski area hotels
In the hotel
Food and drink
- Free hot/cold buffet breakfast
- Coffee/tea in the lobby
Things to do
- Outdoor pool
- Free ski shuttle
- Ski storage
- Fitness facilities
- Number of spa tubs - 3
Working away
- 24-hour business center
- Number of meeting rooms - 2
- Conference space
- Meeting rooms
- Conference space size (feet) - 840
- Conference space size (meters) - 78
- 24-hour front desk
- Dry cleaning/laundry service
- Laundry facilities
- Free newspapers in lobby
- Number of buildings/towers - 1
- Year Built 2002
- Elevator/lift
- ATM/banking
- Safe-deposit box at front desk
- Designated smoking areas
- Fireplace in lobby
- Television in lobby
- Disabled parking
- Accessible path of travel
- Braille or raised signage
- Accessibility equipment for the deaf
- Accessible bathroom
- In-room accessibility
- Roll-in shower
In the room
Home comforts
- Climate control
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
Sleep well
- Hypo-allergenic bedding available
- Blackout drapes/curtains
- Pillowtop mattress
Freshen up
- Private bathroom
- Shower only
- Designer toiletries
- Hair dryer
Be entertained
- 32-inch LCD TV
- First-run movies
- Pay movies
- Premium TV channels
Stay connected
- Desk
- Free weekday newspaper
- Free WiFi
- Free local calls
- Daily housekeeping
Top Steamboat Springs ski area hotels
Recently reviewed hotels in Steamboat Springs ski area
- Chateau Chamonix by Wyndham Vacation RentalsFrom
"Great! Very convenient location. Shawn was exceptionally helpful."Jun 18, 2015
- Trappeur's Crossing Resort & Spa by Wyndham Vacation RentalFrom
"We stayed over the memorial day weekend, and the front desk and hotel staff went above and beyond what was expected.they really made our stay enjoyable and were very knowledgeable…"May 27, 2015
- Quality Inn & SuitesFrom
"This is a beautiful new hotel with a very friendly and welcoming staff. Everything was beautiful, tasteful and comfortable. It was the best night sleep I've had on this 2 week…"May 23, 2015
- The West Condominiums by Wyndham Vacation RentalsFrom
Nearby hotels
Special features
On Site
- Fitness facilities
- Bicycle rentals nearby
- Ecotours nearby
- Golf lessons available nearby
- Golfing nearby
- Hiking/biking trails nearby
- Kayaking nearby
- Mountain biking nearby
- Rafting nearby
- Sailing nearby
- Ski equipment rental shops nearby
- Cross-country skiing nearby
- Downhill skiing nearby
- Snowboarding nearby
- Snowmobiling nearby
- Snowshoeing nearby
- Water skiing nearby
Hampton Inn and Suites Steamboat Springs, Steamboat Springs ski area's small print
Also known as
- Hampton Inn Hotel Steamboat Springs
- Hampton Inn Steamboat Springs
- Steamboat Springs Hampton Inn
- Hampton Inn and Suites Steamboat Springs
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- Resort fee: 4.3 percent of room rate
Resort fee inclusions:
- Internet access (may be limited)
- Phone calls (may be limited)
- Faxes
- Additional inclusions
Inclusions may be listed elsewhere on the page as free or for a surcharge.
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
Hot Chocolate (1911)
December 12th seems to be National Cocoa day in the US. Why? I don't know, but I'll jump on this bandwagon because I came across an old and interesting recipe from an article in the Kansas City Star (December 1911) entitled "Hot Holiday Drinks to Serve". This particular drink peaked my interest because it was titled "Cocoanut Milk Chocolate".… [Continue]
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Twitter Updates
Modern marketing in one sentence: "Do something stupid, take a video, post it on the Internet."
.@mikebasista that paper states "no evidence" because there are few, if any, human studies. Research after this paper indicates activity.
.@mikebasista that is old research, circa 1999. Newer research show hops have estrogenic properties ncbi.nlm.nih.gov/pmc/articles/P…
Are IPA's giving you man boobs? munchies.vice.com/articles/ipas-… #beer
Seltzer is back drnk.ca/sltzr via the Wall Street Journal.
"Consumers still want the fizz—but from seltzer instead" drnk.ca/the-fizz
Pepsi CEO Indra Nooyi told Beverage World's Future Smarts conference that she sees a "huge potential for craft soda" drnk.ca/hipsoda


text:
No matter that Ehud is the best Defense Minister possible. He's not nice. Not with Peretz, not with Cabel, not with Ashkenazy and now Galant. Yet, one FACT is known by everybody: Barak won't go as long as Netanyahu is PM. All of you know that. And, by the way, as long he is there, the Pals and Hezbollah ARE scared to attack again Israel. So,what for are all those articles that he must go, NOW!??? Just to show how united we are?
If selected for publication, it will appear as soon as possible on Haaretz.com.


text:
Originally written on Fox Sports | Last updated 3/8/13
O.J. Mayo scored 22 points and the Dallas Mavericks held on to beat the Detroit Pistons 102-99 on Friday night when Charlie Villanueva missed a 3-pointer in the final seconds. Dallas began the night 4 1/2 games behind eighth-place Utah in the race for the last playoff spot in the Western Conference. The Mavericks blew a 15-point lead in the fourth quarter, allowing Detroit to go ahead 97-96 on a 3-pointer by Khris Middleton. Dirk Nowitzki made two straight shots to put Dallas ahead by three. It was 100-99 after Villanueva caught Jose Calderon's airball and made a layup with 6 seconds left. Darren Collison made two free throws for the Mavericks, and Villanueva missed from the left corner. It was the opener of a four-game road trip for the Mavericks that might represent their last chance to start making up ground and extend their streak of playoff appearances to 13 seasons. Mayo went 5 of 8 from 3-point range and teammate Mike James was 4 of 6. Dallas shot 11 of 21 from beyond the...
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yes. at the end of the roubo build my existing bench will have to go.
so if you are in the uk and not availing yourself of a fine roubo then my beech one is up for grabs.
I have just fitted a face veritas twin screw and given it an overhaul.
I am thinking it will be available march /April time. very much dependent upon receiving the bench hardware from the US.
I know I need to post a picture and will do so soon.
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bench with veritas twin screw UK
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Proof that we all look stupid sometimes.
When you take as many photos as I do when I travel – some of them are bound to…September 13, 2014
When you take as many photos as I do when I travel – some of them are bound to…September 13, 2014
Whilst we were recently in Las Vegas, we were lucky enough to be invited to The Foundation Room at…September 8, 2014
When you live in a city like London, holidays and time off are majorly important, because getting out of…August 17, 2014
When I visited Las Vegas last year, Pad and I stayed in The Venetian Hotel and that was when…June 12, 2014
One of my biggest confusions when travelling is knowing when and how much to tip. I hate the idea…May 21, 2014
You'd never imagine that a small, tiny, alpine village in the remote country of New Zealand would be such…May 3, 2014
I've written about my fear of flying previously, and to this day it remains on of the most emotional…May 1, 2014
I like GIFs. I also like travelling. So I thought I would combine these loves to make an awesome…April 25, 2014
The folks over at Blacks (who do outdoor clothing and adventure gear) are currently running a competition for bloggers…April 7, 2014
Last year in the midst of our RTW trip, we got an email from our friends back home, announcing…March 22, 2014
Since being back in London and being back in a full time job, sometimes it's difficult to find time…March 22, 2014
I'm a huge photography geek, so when I was invited to try out the new Autographer camera on my…February 27, 2014
I'd be kidding myself if I said the shops weren't one of the reasons I love NYC so much……February 23, 2014
You know sometimes, when you flick through those interior and home magazines – and you're like… 'Yes. Very nice.…February 17, 2014
I've been wanting to write about the reality of living in London ever since moving back here last summer…January 26, 2014
2013 has without a doubt been the best year of my life. We've been to more places than I…December 30, 2013
Last Christmas, Pad and I spent the day on Queenstown beach, sipping cider and wearing santa hats (more on…December 28, 2013
2013 has been a pretty good year for me…. after months and months of planning and organising our big…December 18, 2013
Pad and I have a habit of getting unlucky with weather. When we were in Australia, Thailand, Hong Kong…December 15, 2013
I was invited up to The Aqua Shard to celebrate my birthday with a guest (I choose my lovely…December 10, 2013
One of my favourite places in Paris, the Padlock Bridge, is one of those spots you should really try…December 4, 2013
I've never been on Eurostar before, so when they offered me some free return tickets to review it, I…November 16, 2013
A lovely friend of mine Harriet is heading to NYC this week, and she dropped me an email asking…October 27, 2013
This month has been pretty busy (hence the lack of posts!) – but I just wanted to write a…October 24, 2013
So… The Cosmopolitan Blog Awards hey?! After only a year of travel blogging it was so amazing to be…October 3, 2013
Ever since we got back from travelling in the summer, I've been dreaming of our next trip away –…September 25, 2013
We got invited to spend a night at the beautiful St Ermin's hotel in London, so I wanted to…September 22, 2013
I love finding those amazingly good-value-super-cheap eats around big cities, so thought I'd put together a post about my…September 17, 2013
As far as European city destinations go, Dublin wouldn't make my top 5 – but that doesn't mean I…September 15, 2013
I was always going to travel. Whether it was on my own or maybe with a friend (or boyfriend…September 14, 2013
I'm Elle, a twenty-something London girl who has a serious case of wanderlust.
If you like photography and travelling - hopefully you'll find something you like here. Feel free to get in touch!


text:
Created in this Craftsy class
Quilt-As-You-Go Patchwork Bags taught by Tara Rebman
Add spontaneous piecing to your bag of quilting tricks and make a beautiful patchwork tote designed by Tara Rebman.
Other projects made as part of this class:
QuiltingQAYG COMFORT BAG
QuiltingPurple Party Bag
QuiltingCustom Laptop Bag
Offer some kudos...
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Holy cow! These are awesome! Way to go with your high productivity!!
11/21/2013 Flag
These are fabulous!
11/21/2013 Flag
These are fabulous. Love the dark binding and that they are squared off. Your gift recipients will LOVE them! :) Great job.
11/22/2013 Flag
Love your colors and use of black - the border really makes these "pop" as they say!!
08/02/2014 Flag


text:
How did three Danes end up being tortured in Lebanon?
Saving Afghanistan's archaeological sites
17 Jul 2013 00:19 GMT | Politics, Middle East, US & Canada, China, Egypt
Six thousand people are fleeing Syria every day as the conflict intensifies and merges with violence in neighbouring Iraq, United Nations officials have said.
The warnings were given on Tuesday at a rare public briefing of the UN's Security Council in New York
The High Commissioner for Refugees, Antonio Guterres, told the meeting that the organisation had "not seen a refugee outflow escalate at such a frightening rate since the Rwandan genocide almost 20 years ago".
Ivan Simonovic, the Assistant Secretary-General for Human Rights, told the meeting that at least 92,901 people were killed in Syria - among them more than 6,500 children - between March 2011 and the end of April 2013.
"The extremely high rate of killings nowadays - approximately 5,000 a month - demonstrates the drastic deterioration of the conflict," Simonovic told the council meeting.
Guterres said that two-thirds of the nearly 1.8m refugees registered with the UN in Lebanon, Turkey, Jordan, Iraq, Egypt and elsewhere had left Syria since the beginning of the year.
The UN envoy to Iraq, Martin Kobler, later gave warning that escalating violence in Iraq could no longer be separated from the war in Syria because "the battlefields are merging".
Kobler said Iraqi armed groups had an increasingly active presence in Syria and as a result, the Syrian conflict is no longer just spilling over into Iraq, but Iraqis are reportedly taking arms against each other inside Syria.
"These countries are interrelated," Kobler stressed. "Iraq is the fault line between the Shia and the Sunni world and everything which happens in Syria, of course, has repercussions on the political landscape in Iraq."
Kobler said the last four months have been among the bloodiest in Iraq in the last five years with nearly 3,000 people killed and over 7,000 injured.
The Security Council has been deadlocked on Syria.
Russia, an ally of Syrian President Bashar al-Assad, and China have three times blocked action against Assad that was backed by the remaining veto powers - the US, Britain and France.
Al Jazeera's diplomatic editor, James Bays, reporting from the UN in New York said that the UN representatives pointed out that there are restrictions set by the Syrian government in getting aid to people.
"Only 14 international aid organisations are allowed in," he said.
Syria's UN Ambassador Bashar Ja'afari said the Syrian government was doing "everything possible to shoulder its responsibility and its duty to its people, to meet the humanitarian needs and the basic needs of its citizens."
UN aid chief Valerie Amos said the world was "not only watching the destruction of a country but also of its people".
She said 6.8m Syrians need urgent humanitarian assistance, including more than 4.2m internally displaced, and that almost half of those needing help were children.
The latest assessment by the World Food Programme was that four million people can no longer meet their basic food needs.
Source: Al Jazeera and agencies
UN seeks $1.5bn as 60 nations meet in Kuwait to discuss growing needs of people displaced by ongoing conflict.
Politics, Middle East, Kuwait, Lebanon, Syria
Activists report government air attacks on area in capital inhabited by Palestinian refugees and displaced Syrians.
Politics, Middle East
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Changing climate, unpredictable rains dry out the land, threaten the pastoral way of life in Somaliland.
Poverty & Development, Environment, Africa
Tensions rise as Greeks from both side of the bailout debate take to the streets to withdraw money and express angst.
Politics, Europe, Greece
The world's biggest producer and consumer of the metal sees a golden opportunity to expand its pricing power.
Business & Economy, Asia, China
Normalised Cuba-US relations could result in a hybrid economic model blending socialism and entrepreneurial spirit.
Business & Economy, Communism, Politics
Rival sides of Greece's debt debate rally days before voters are to decide on whether to reject creditors' conditions.
Politics, Business & Economy, Europe, Greece
Nigerian president under pressure to act as string of bloody attacks hit northern towns, killing more than 160 people.
War & Conflict, Humanitarian crises, Africa, Nigeria, Boko Haram
After decades of tension and hostility between the two nations, has change finally come to US-Cuba relations?
As the Baku games close, we examine the challenges facing journalists; plus, Angola, Portugal and 'reverse colonialism'.
Media, Europe, Azerbaijan
How Brazil's football legend turned every Corinthians' match into a political meeting for democracy.
Politics, Football, Latin America
The ICC chief prosecutor discusses Sudan's president escaping justice in South Africa and alleged war crimes in Gaza.
Politics, ICC, South Africa


text:
Onion Cornbread
Total Time
Prep 15 mins
Cook 20 mins
Skillet corn bread with onions
Make and share this Onion Cornbread recipe from Food.com.
Ingredients Nutrition
- Chop the onion and sautee it in the skillet with the butter.
- (It's more butter than you need for the onion, but it will all go into the mix.) In a bowl, fully mix the dry ingredients.
- Separately, beat the eggs with the milk.
- Combine the egg and milk mixture and the sauteed onions and butter with the dry ingredients.
- Pour the mix into the skillet.
- Place the skillet in a 400 degree oven and bake for about 20 minutes.
- Enjoy it with honey.
Most Helpful
This was terrific. The addition of the sauteed onion gave a nice change from ordinary corn bread.This went great with a pot of spicey chili on a cold winter night.


text:
Are you M Martinetti?Claim your profile
Publications (155)500.49 Total impact
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ABSTRACT: Autoimmune rheumatic diseases in pregnancies are associated with increased adverse obstetric outcomes. We compared maternal soluble human leucocyte antigen-G (sHLA-G) blood levels in subjects with a rheumatic disease preexisting pregnancy and unaffected controls. Third-trimester blood maternal sHLA-G concentrations were significantly higher in subjects with rheumatic diseases than in controls (mean 93.1ng/ml [SD 42.1] vs 58.1ng/ml [SD 96.3], p=0.003). Cord blood sHLA-G concentrations were significantly higher in rheumatic disease than in those born to control mothers (median 41.2ng/ml [IQR: 3.3-44.0] vs 17.9ng/ml [IQR: 17.2-88.1], p=0.007). A strict positive correlation (r=0.88, p<0.001) was found between the maternal and fetal titers of ANA autoantibodies as well as between maternal and fetal sHLAG circulating levels (r=0.58 and r=0.67, respectively, for controls and cases, p<0.001). Maternal s-HLA-G blood concentrations were significantly higher in subjects with rheumatic disease DEL/DEL homozygous for a polymorphism of the 3' untranslated regulatory region of HLA-G (HLA-G 14bp) than in the corresponding healthy controls (mean values 141.5ng/ml [SD: 166] vs 54.2ng/ml [SD: 35], p=0.009). Increasing maternal and cord blood levels of s-HLA-G concentrations among pregnant subjects with rheumatic diseases compared with controls suggest that autoimmune diseases prompt a maternal and fetal immune response that favors pregnancy immune tolerance. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.Journal of Reproductive Immunology 08/2015; 110. DOI:10.1016/j.jri.2015.04.005
Article: Mycosis fungoides: association of KIR ligands and HLA-DQB1*05 with bad prognosis of the disease[Show abstract] [Hide abstract]
ABSTRACT: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. We previously reported that the prognosis of MF patients is not only related on clinical variables but it is also associated with peculiar HLA alleles. Until today, the association of HLA ligands for KIR with the prognosis of the disease has not yet been analysed. We investigated the frequency of HLA ligands for killer cell Immunoglobulin-like receptors (KIRs) in MF patients, evaluating if the presence of particular HLA alleles that are ligands for KIR may have prognostic value. The study includes 46 Caucasian MF patients that, between 1993 and 1997, underwent HLA genomic typing. All patients were diagnosed and followed up from 1977 to 2012 (mean follow-up of 11 years). MF patients have been divided into two groups (long survivors and dead patients). We noticed that the HLA-Bw6/Bw6 specificity increased among the group of seven dead patients compared to the group of 39 long survivors (71.4% vs. 41.0%, P = ns, OR = 3.59), while in the long survivors group the HLA- Bw4/Bw4 specificity increased when compared to dead patients (23.0% vs. 0%, P = ns). Moreover, we observed that six of the seven dead patients had HLA-DQB1*05; the phenotypic frequency of this HLA allele, in dead and long survivors patients, was 85.7% and 23.0% respectively (P = 0.004; OR = 20). Our observations suggest that the presence of the HLA-DQB1*05 alleles characterizes the patients with the poorest prognosis in MF. In addition, absence of the KIR-ligand epitope HLA-B Bw4 showed a trend of being more prominent in MF patients with the poorest prognosis. © 2015 European Academy of Dermatology and Venereology.Journal of the European Academy of Dermatology and Venereology 03/2015; DOI:10.1111/jdv.13083
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ABSTRACT: Background: Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) may develop in susceptible patients after administration of different drugs. Only mild cutaneous reactions have been related to lomefloxacin. A correlation between human leucocyte antigen (HLA) and cutaneous adverse reaction has been identified. Case Report: Twenty-four hours after intake of lomefloxacin, a 30-year-old Caucasian woman developed a severe skin reaction with symptoms suggesting SJS/TEN. The fast onset reaction worsened with skin blisters and 20% body surface area skin detachment within 48 h. Burn unit admittance was required; corticosteroids and human immunoglobulins were administered. Complete recovery occurred within 3 months, except for epidermal discoloration. Molecular studies showed a peculiar profile characterized by HLA class I genotype rich of ligands for natural killer cell immunoglobulin-like receptors (KIR) and HLA class II haplotype, HLA-DRB1*03:01,DQB1*02:01, prone to autoimmunity. Conclusion: While the HLA profile approaches our case to other well-documented drug-induced SJS/TEN, KIR involvement still remains puzzling. © 2014 S. Karger AG, Basel.Dermatology 10/2014; DOI:10.1159/000365188
Article: Temporal Variation in Soluble Human Leukocyte Antigen-G (sHLA-G) and Pregnancy-Associated Plasma Protein A (PAPP-A) in Pregnancies Complicated by Gestational Diabetes Mellitus and in Controls[Show abstract] [Hide abstract]
ABSTRACT: Problem To target gestational diabetes mellitus (GDM) by means of temporal variation in pregnancy-associated plasma protein A (PAPP-A) and soluble human leukocyte antigen-G (sHLA-G). Method of studyRetrospective analysis of PAPP-A and sHLA-G blood levels in historical samples of 112 GDM and 112 controls, drawn at first trimester, and prospective study in 18 GDM and 105 controls collected in triplicate along the pregnancy. Six hundred and sixty-five samples were analyzed. ResultsGestational diabetes mellitus had significantly lower first-trimester PAPP-A concentrations than controls (23431519 versus 2996 +/- 1955 mU/mL, in retrospective brunch and 2490.57 +/- 1828.52 versus 3240.84 +/- 1930.69mU/L in prospective one, P<0.001). First-trimester sHLA-G level was significantly lower in GDM than in controls (52.88 +/- 59.69 versus 66.81 +/- 50.14ng/mL, P<0.001) and increased during gestation in diabetic women showing an opposite trend with respect to the controls. ConclusionPAPP-A and sHLA-G are independent markers of GDM. Quantitative variations during pregnancy help to early unravel the onset of GDM.American journal of reproductive immunology (New York, N.Y.: 1989) 05/2014; 72(4). DOI:10.1111/aji.12270
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ABSTRACT: The killer cell immunoglobulin-like receptor (KIR)-human leukocyte antigen (HLA) interaction represents an example of genetic epistasis, where the concomitant presence of specific genes or alleles encoding receptor-ligand units is necessary for the activity of natural killer (NK) cells. Although KIR and HLA genes segregate independently, they co-evolved under environmental pressures to maintain particular KIR-HLA functional blocks for species survival. We investigated, in 270 Italian healthy individuals, the distribution of KIR and HLA polymorphisms in three climatic areas (from cold north to warm south), to verify their possible geographical stratification. We analyzed the presence of 13 KIR genes and genotyped KIR ligands belonging to HLA class I: HLA-C, HLA-B and HLA-A. We did not observe any genetic stratification for KIR genes and HLA-C ligands in Italy. By contrast, in a north-to-south direction, we found a decreasing trend for the HLA-A3 and HLA-A11 ligands (P = 0.012) and an increasing trend for the HLA-B ligands carrying the Bw4 epitope (P = 0.0003) and the Bw4 Ile80 epitope (P = 0.0005). The HLA-A and HLA-B KIR ligands were in negative linkage disequilibrium (correlation coefficient -0.1211), possibly as a consequence of their similar function in inhibiting NK cells. The distribution of the KIR-HLA functional blocks was different along Italy, as we observed a north-to-south ascending trend for KIR3DL1, when coupled with HLA-B Bw4 ligands (P = 0.0067) and with HLA-B Bw4 Ile80 (P = 0.0027), and a descending trend for KIR3DL2 when coupled with HLA-A3 and HLA-A11 ligands (P = 0.0044). Overall, people from South Italy preferentially use the KIR3DL1-HLA-B Bw4 functional unit, while those from the North Italy equally use both the KIR3DL2-HLA-A3/A11 and the KIR3DL1-HLA-B Bw4 functional units to fight infections. Thus, only KIR3DL receptors, which exert the unique role of microbial sensors through the specific D0 domain, and their cognate HLA-A and HLA-B ligands are selectively pressured in Italy according to geographical north-to-south distribution.Tissue Antigens 03/2014; 83(3):168-73. DOI:10.1111/tan.12299
Article: Immunogenetic factors in mycosis fungoides: can the HLA system influence the susceptibility and prognosis of the disease? Long-term follow-up study of 46 patients.[Show abstract] [Hide abstract]
ABSTRACT: Mycosis fungoides (MF) is the most common and one of the least aggressive forms of cutaneous T-cell lymphoma. Several studies have demonstrated the influence of human leucocyte antigen (HLA) genes on the susceptibility of MF, highlighting the importance of certain alleles but, until today, no studies have evaluated the relationship between HLA alleles and the prognosis of patients with MF. The aim of this retrospective cohort study was to evaluate the polymorphism of HLA class I and class II alleles in a group of 46 MF Caucasian patients, looking for their influence in susceptibility and prognosis of the disease. Study population included a case-cohort sample of 46 Caucasian patients with MF that, between 1993 and 1997, underwent HLA class I and II genomic typing. All patients were diagnosed and followed up from 1977 to 2012 (mean follow-up of 11 years) and they were divided into three groups according to the evolution of the disease. Molecular typing at low-resolution level revealed that HLA-A*24, A*68, A*69, B*35 and DQB1*05:02 alleles were involved in susceptibility to MF. Correspondence analysis underlined that long-lasting remission was characterized by HLA-A*24 and HLA-A*25 alleles, frequent relapse by HLA-DRB1*01, DQA1*01:01, DQB1*05:01 alleles and death by HLA-A*68, HLA-B*08, HLA-B*35, HLA-C*03 alleles. This study suggests that the prognosis of MF patients is not only correlated with clinical/pathological/serological/immunological variables but it also relies on specific HLA alleles.Journal of the European Academy of Dermatology and Venereology 02/2014; DOI:10.1111/jdv.12391
Article: Multicenter Analyses Demonstrate Significant Clinical Effects of Minor Histocompatibility Antigens on GvHD and GvL after HLA-Matched Related and Unrelated Hematopoietic Stem Cell Transplantation[Show abstract] [Hide abstract]
ABSTRACT: The effect of minor H antigen mismatching on the occurrence of GvHD and GvL after HLA-matched hematopoietic stem-cell transplantation (HSCT) has mainly been demonstrated in single center studies. Yet, the International Histocompatibility and Immunogenetics Workshops (IHIWS) provide a collaborative platform to execute crucial large studies. In collaboration with 20 laboratories of the IHIWS, the role of 10 autosomal and 10 Y-chromosome encoded minor H antigens was investigated on GvHD and relapse incidence in 639 HLA-identical related donor (IRD) and 210 HLA-matched unrelated donor (MUD) HSCT. Donor and recipient DNA samples were genotyped for the minor H antigens HA-1, HA-2, HA-3, HA-8, HB-1, ACC-1, ACC-2, SP110, PANE1, UGT2B17, and HY. The correlations with the primary outcomes GvHD (acute or chronic GvHD), survival, and relapse were statistically analyzed. The results of these multi-center analyses show that none of the HLA class I-restricted HY antigens were found to be associated with any of the primary outcomes. Interestingly, of the HLA class II-restricted HY antigens analyzed, HLA-DQ5 positive recipients showed a significantly increased GvHD-free survival in female-to-male HSCT compared to male-to-female HSCT (p=0.013) in HLA-DQ5-positive recipients. Yet, analysis of the overall gender effect, thus independent of the known HY antigens, between the gender groups demonstrated an increased GvHD incidence in the female to male transplants (p<0.005) and a decreased GvHD free survival in the female to male transplants (p<0.001). Of all autosomally encoded minor H antigens, only mismatching for the broadly expressed minor H antigen HA-8 increased the GvHD incidence in IRD HSCT (Hazard Ration (HR)=5.28; p<0.005), but not in MUD HSCT. Most striking was the influence of hematopoietic restricted minor H antigens on GvL as mismatching for hematopoietic minor H antigens correlated with lower relapse rates (p=0.078), higher relapse free survival (p=0.029) and higher overall survival (p=0.032) in recipients with GvHD, but not in those without GvHD. In conclusion, the significant GvHD effect of the broadly expressed minor H antigen HA-8 favors matching for HA-8 in IRD, but not in MUD, patient/donor pairs. The GvHD-GvL association demonstrating a significant lower relapse in hematopoietic minor H antigen mismatched patient/donor pairs underlines their clinical applicability for adoptive immunotherapy enhancing the GvL effect in a GvHD controllable manner.Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation 06/2013; 19(8). DOI:10.1016/j.bbmt.2013.06.001
Article: OC.12.3 IMMUNOMODULANT EFFECTS OF MESENCHYMAL STROMAL CELLS (MSC) ON GLIADIN-SPECIFIC T CELL LINESDigestive and Liver Disease 03/2013; 45:S82. DOI:10.1016/S1590-8658(13)60225-X
Article: The plasma levels of soluble HLA-G molecules correlate directly with CD34+cell concentration and HLA-G 14bp insertion/insertion polymorphism in cord blood donors[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Cord blood provides haematopoietic stem cells for allogeneic transplantation and, thanks to the naivety of its immune system, has several advantages over other sources of stem cells. In the transplantation setting, the presence of immunosuppressive human leucocyte antigen (HLA)-G molecules has been advocated to prevent both rejection and Graft-versus-Host disease. HLA-G is physiologically expressed throughout pregnancy and is contained in cord blood at birth. Moreover, it has recently been reported that not only cord blood mesenchymal cells, but also CD34(+) cell progenies produce soluble HLA-G (sHLA-G). We tried to identify the largest producer of sHLA-G among 85 healthy cord blood donors at Pavia Cord Blood Bank, correlating the sHLA-G concentration with the HLA-G 14bp insertion/deletion (INS/DEL) genotype and CD34(+) cell concentration. MATERIALS AND METHODS: We measured sHLA-G levels in 36 cord blood plasma stored at 20 °C for 2 months and 49 cord blood plasma stored at 196 °C for 4-6 years, by enzyme-linked immunosorbent assay. All cord blood donors were genotyped for the HLA-G 14bp INS/DEL polymorphism by polymerase chain reaction. For each cord blood unit, we measured the cell concentration by flow cytometry. RESULTS: We did not find differences in sHLA-G levels between cord blood plasma aliquots stored for 4-6 years at 196 °C and cord blood plasma aliquots stored for 2 months at 20 °C. We observed a higher sHLA-G concentration in cord blood plasma donors who carried the HLA-G 14bp INS/INS genotype and had higher CD34(+) cell concentrations (P =0.006). DISCUSSION: This is the first report showing that the best cord blood stem cell donor is also the best sHLA-G producer, particularly if genetically characterized by the HLA-G 14bp INS/INS genotype. If the therapeutic role of sHLA-G molecules were to be finally established in the transplantation setting, our data suggest that cord blood plasma donors can provide a safe source of allogeneic sHLA-G immunosuppressive molecules ready for transfusion.Blood transfusion = Trasfusione del sangue 01/2013; 12:1-6. DOI:10.2450/2012.0144-12
Article: Targeting the Immunogenetic Diseases with the Appropriate HLA Molecular Typing: Critical Appraisal on 2666 Patients Typed in One Single Centre[Show abstract] [Hide abstract]
ABSTRACT: We compared the immunogenetic data from 2666 patients affected by HLA-related autoimmune diseases with those from 4389 ethnically matched controls (3157 cord blood donors CBD, 1232 adult bone marrow donors BMD), to verify the appropriateness of HLA typing requests received in the past decade. The frequency of HLA-B∗27 phenotype was 10.50% in 724 ankylosing spondylitis, 16.80% in 125 uveitis (3.41% BMD, 4.24% CBD, P < 0.0001); HLA-B∗51 allele was 15.57% in 212 Behçet's disease (12.91% BMD, 9.88% CBD, P < 0.0001); the HLA-DRB1-rheumatoid arthritis (RA) shared epitope was 13.72% in 554 RA (10.85% BMD, 13.48% CBD, P = 0.016); the carriers of almost one of HLA-DQB1 susceptibility alleles were 84.91% in 795 celiac disease (CD) and 59.37% in 256 insulin-dependent diabetes mellitus (IDDM) (46.06% in 875 CBD, 42.75% in 662 BMD P < 0.0001). Overall, our results show that the HLA marker frequencies were higher in patients than controls, but lower than expected from the literature data (excluding CD and IDDM) and demonstrate that, in complex immunogenetic conditions, a substantial number of genetic analyses are redundant and inappropriate, burdening to the public health costs. For this reason, we suggest the Italian Scientific Society of Immunogenetics to establish guidelines to improve the appropriateness of typing requests.01/2013; 2013:904247. DOI:10.1155/2013/904247
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ABSTRACT: Whipple's disease (WD) is a very rare chronic systemic condition characterised by a Th2/T regulatory (Treg) dysregulated immune response versus Tropheryma whipplei, a bacterium widely diffuse in the environment. To investigate whether this Th2/Treg polarised response has a genetic background, we investigated the Th1, Th2, Th17 and Treg cytokine genetic profile of 133 patients with WD. Thanks to the European Consortium on WD (QLG1-CT-2002-01049), the polymorphism of 13 cytokine genes was analysed in 111 German and 22 Italian patients using the polymerase chain reaction with sequence-specific primers (PCR-SSP) technique. The frequencies of the genotypes, haplotypes and functional phenotypes were compared with those obtained in 201 German and 140 Italian controls. Clinical heterogeneity was also considered. Functionally, WD patients may be considered as low producers of TGF-β1, having an increased frequency of the genotype TGF-β1+869C/C,+915C/C [12.3 % vs. 3.81 %, odds ratio (OR) = 4.131, p = 0.0002] and high secretors of IL-4, carrying the genotype IL-4-590T/T (5.34 % vs. 1.17 %, OR = 5.09, p = 0.0096). No significant association was found between cytokine polymorphism and clinical variability. Analogously to the recent cellular findings of a Th2/Treg polarised response, we showed that the cytokine genetic profile of WD patients is skewed toward a Th2 and Treg response. This was similar in both German and Italian populations. However, the significant deviations versus the controls are poorer than that expected on the basis of these recent cellular findings.European Journal of Clinical Microbiology 07/2012; 31(11):3145-50. DOI:10.1007/s10096-012-1677-8
Article: Common immunogenetic profile in children with multiple autoimmune diseases: the signature of HLA-DQ pleiotropic genes.[Show abstract] [Hide abstract]
ABSTRACT: Type 1 diabetes mellitus (T1DM), celiac disease (CD) and autoimmune thyroid disease (ATD) are autoimmune conditions relatively common in paediatric age and frequently occur in association in the same subject. This event is not by chance and requires an explanation. Here, we studied the distribution of HLA-DQ αβ heterodimers in 334 Italian children with T1DM, ATD and CD alone or in association and in 224 Italian healthy controls. In particular, 164 patients had T1DM (133 alone, 20+ATD, 7+CD and 4+CD+ATD), 118 had ATD (110 alone, 8+CD) and 52 had CD (40 alone, 11+ATD and 1+T1DM). 51 patients suffered from multiple autoimmune diseases. The risk for multiple autoimmune diseases was significantly associated with the increased number of HLA-DQ markers of susceptibility for both T1DM (p = 0.003) and CD (p = 0.006). The presence of one or more diabetogenic DQ molecules significantly increased the probability of developing not only T1DM (p < 0.001) but also CD (p < 0.001) and ATD (p = 0.001). Similarly, the presence of one or more celiac HLA-DQ heterodimers significantly increased the likelihood of developing not only CD (p < 0.001), but also T1DM (p < 0.001) and ATD (p < 0.001). We confirm that the sharing of the immunogenetic background is responsible for the development of multiple autoimmune diseases although with a different risk according to the number and type of susceptible HLA-DQ heterodimers as reported in the algorithm proposed here. It is likely that combinations of DQA1 and DQB1 alleles are the real culprits of the progression towards multiple autoimmune diseases and HLA-DQ genomic typing will improve the capability to predict associated autoimmune diseases in infancy.Autoimmunity 06/2012; 45(6):470-5. DOI:10.3109/08916934.2012.697594
Article: Possible KIR-driven genetic pressure on the genesis and maintenance of specific HLA-A,B haplotypes as functional genetic blocks.[Show abstract] [Hide abstract]
ABSTRACT: The HLA genomic structure underlines the permanence of fixed haplotypes transmitted in blocks as allelic combinations. One of the most discussed concerns is how and why such a strong linkage between HLA alleles has been maintained for so long. We hypothesized a possible KIR-driven pressure in the genesis of specific HLA-A,B haplotypes. Certain HLA-A and -B molecules are ligands for the same KIR receptors through the Bw4 binding motif spanning residues 77-83 in the α1 domain. We analyzed the HLA-A and -B genomic types of 9897 Caucasian people (3533 newborns and 6364 adults) subdividing them according to the presence/absence of the HLA-B Bw4 serological epitope. For each HLA-B Bw4- and Bw6-cross-reactive group, we evaluated the presence/absence of HLA-A ligands for KIR3DL1 (HLA-A*23, HLA-A*24, HLA-A*32) and KIR3DL2 (HLA-A*03, HLA-A*11). The frequency of HLA-A KIR ligands significantly increased moving from the HLA-B Bw4/Bw4 to the HLA-B Bw4/Bw6 and the HLA-B Bw6/Bw6 groups among both newborns and adults (P<0.0001). Here, we suggest that, when the HLA-B KIR-ligand motif is lacking, the HLA-A KIR-ligand might have a vicarious role in controlling the natural killer cell-mediated innate immune response. Basing upon this compensatory function in the engagement of KIR receptors, we hypothesize that specific HLA-A,B ancestral haplotypes were generated.Genes and immunity 05/2012; 13(6):452-7. DOI:10.1038/gene.2012.14
Article: OC.10.5 CLUSTER OF ENTEROPATHIES NEGATIVE FOR COELIAC DISEASE GENETICS BUT CARRYING HLA DQ6Digestive and Liver Disease 03/2012; 44:S78. DOI:10.1016/S1590-8658(12)60208-4
Article: Intragenomic conflict of maternal HLA haplotypes: A potential link between vigorous intrauterine growth and risk of autoimmunity in adulthoodMolecular Reproduction and Development 03/2012; 79(3):162. DOI:10.1002/mrd.21408
Article: Tag SNPs of the ancestral haplotype 57.1 do not substitute HLA-B*57:01 typing for eligibility to abacavir treatment in the Italian population.[Show abstract] [Hide abstract]
ABSTRACT: A letter in response to: Sanchez-Giron F, Villegas-Torres B, Jaramillo-Villafuerte K et al. Association of the genetic marker for abacavir hypersensitivity HLA-B*5701 with HCP5 rs2395029 in Mexican Mestizos. Pharmacogenomics 12(6), 809-814 (2011).Pharmacogenomics 02/2012; 13(3):247-9. DOI:10.2217/pgs.11.168
Article: In Vitro Evaluation of Graft-versus-Graft Alloreactivity as a Tool to Identify the Predominant Cord Blood Unit before Double Cord Blood Transplantation[Show abstract] [Hide abstract]
ABSTRACT: The transplantation of two cord blood (CB) units obtained from unrelated donors (double CBT) is an effective strategy for adult patients with hematologic malignancies. Sustained hematopoiesis after double CBT is usually derived from a single donor, and only a few transplantation recipients displaying a stable mixed donor-donor chimerism have been reported. We investigated the mechanisms underlying single-donor predominance in double CBT by studying in vitro the role of the graft-versus-graft cell-mediated immune effect in two-way mixed-lymphocyte culture, along with the contribution of differential hematopoietic progenitor (HP) potency in HP mixed cultures. Results for the two-way mixed-lymphocyte culture showed that despite the weak and variable alloantigen-specific cytotoxic potential displayed by CB mononuclear cells, an immune-mediated dominance for one of the two CB units was detected in the majority of experiments. Alloantigen-induced cytotoxic activity was directed toward both CB-HP and phytohemagglutinin (PHA)-activated T lymphoblastoid cells. The CB unit with the higher fold expansion of CD34(+) cells in single-expansion culture was prevalent in the HP mixed-expansion culture, as shown by DNA chimerism evaluation. Based on these data, we hypothesize that the dominant CB unit is able to develop prevalent cytotoxic activity toward activated lymphocytes of the other CB unit, thereby preventing them from exerting alloantigen-specific cytotoxic potential against both activated lymphocytes and HPs of the dominant unit. In accordance with this hypothesis, we propose the evaluation of alloantigen-induced cytotoxic activity generated in two-way mixed-lymphocyte culture and directed toward PHA-activated T lymphoblastoid cells as a tool to identify the potentially predominant CB unit before double CBT.Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation 01/2012; 18(7):1108-18. DOI:10.1016/j.bbmt.2011.12.586
Article: Implementing non-invasive RHD genotyping on cell-free foetal DNA from maternal plasma: the Pavia experience[Show abstract] [Hide abstract]
ABSTRACT: The occurrence of cell-free foetal DNA in maternal circulation opens new possibilities in non-invasive antenatal diagnosis. Real-time polymerase chain reaction (PCR) analysis is an useful approach to foetal RhD blood group determination, thus being important in the prevention of haemolytic disease of foetus and new-born (HDFN). Using real-time PCR assays we typed 20 samples of plasma, provided in a blinded fashion, from the International Reference Laboratory, two plasma samples sent by the "2010 Workshop on Molecular Blood Group Genotyping"; seven samples from D-negative mothers at the 16th week of gestation provided by our Hospital as prospective validation cases, and two plasma samples received from the "1(st) Collaborative study establishing the sensitivity standard for non-invasive prenatal determination of foetal RHD genotype". To confirm the RHD typing of the seven prospective samples, PCR with sequence specific primers (PCR-SSP) was applied on genomic DNA from amniocytes (5 cases) and paternal peripheral blood (2 cases). The results for the 31 investigated samples showed 100% concordance. Our measurable benefits were: confidence with a new technology, awareness of having gained the European standard level and increased self-assurance regarding the introduction of this typing technique in prenatal diagnostics. These results demonstrate the feasibility and accuracy of our validation protocol. RHD typing on cell-free foetal DNA is a procedure which requires particular care and a great degree of expertise for diagnostic use. International collaborations are essential for monitoring the performance of laboratories in the absence of specific quality control programmes.Blood transfusion = Trasfusione del sangue 11/2011; 10(1):34-8. DOI:10.2450/2011.0021-11
Article: A new approach to safely type for HLA the HIV infected people eligible to abacavir therapy: Saliva or buccal swab as reliable DNA sources[Show abstract] [Hide abstract]
ABSTRACT: Increasing the safety in Immunogenetics Labs, in the era of antiretroviral pharmacogenomics, represents an imperative goal. To this purpose, we tested saliva and buccal cells as biological sources of DNA, alternative to peripheral blood, for HLA-B*57:01 genomic typing of HIV positive patients eligible to treatment with abacavir. Blood, saliva and buccal cells of 20 voluntary donors and 20 HIV positive patients were collected. DNA was extracted with a manual commercial kit and an automated platform. Quality and quantity of DNA was evaluated with different procedures. The suitability and reliability of DNAs for HLA-B*57:01 genotyping was checked at low and high resolution level, using PCR-SSP (sequence specific primers PCR), revPCR-SSO (reverse sequence specific oligonucleotides PCR), bead array and SBT (sequence based typing) techniques. DNA concentrations were qualitatively very good and quantitatively comparable in all the specimens tested with an inferior yield for cotton swabs. Comparing the results of HLA typing with different methodologies, the 100% of reproducibility was achieved. The viral load of buccal epithelial cells or saliva is extremely low. Here we demonstrated that the DNA from these alternative sources is appropriate for HLA-B*57:01 typing. We strongly recommend the use of this procedure to increase the safety in the lab when dealing with infectious samples.Clinica chimica acta; international journal of clinical chemistry 10/2011; 412(21-22):1995-8. DOI:10.1016/j.cca.2011.07.003
Top Journals
Policlinico San Matteo Pavia Fondazione IRCCS
Ticinum, Lombardy, Italy
- s.c. Oncoematologia Pediatrica
University of Pavia
Ticinum, Lombardy, Italy
- • Department of Biology and Biotechnology "Lazzaro Spallanzani"
- • Department of Internal Medicine and Therapeutics
- • Department of Diagnostic, Paediatric, Clinical and Surgical Science
Policlinico S.Orsola-MalpighiBolonia, Emilia-Romagna, Italy
Istituto di Cura e Cura a Carattere Scientifico BasilicataRionero in Vulture, Basilicate, Italy
National Research CouncilRoma, Latium, Italy


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The Center's current and future educational programs, exhibits and collections will be discussed as well as the opening of The HHCTX Museum in the Fall 2015. Now, more than ever, The HHCTX shines new light on Hispanic history. The HHCTX works to ensure that our collections, exhibitions, research, publications and educational programs all support the Center's mission.
Ms. Arredondo-Haskins comes from a long line of prominent military and business leaders. She descends directly from Sergeant Major Diego Ramón, co-founder of Mission San Francisco de Solano, the same mission to eventually be known as the Alamo. Her ancestors also include the 14th Family of the Canary Islanders who established the Villa de San Fernando de Béxar in 1731. She has devoted many years of scholarly research to Don Domingo Bustillo, as she is a direct descendant of the well-esteemed Bustillo family who were heavily involved in the business and civic affairs of early San Antonio.
In addition to being the Executive Director at The Hispanic Heritage Center of Texas, she is a scholar, a proud and active member of the Daughters of the Republic of Texas Alamo Couriers Chapter, a YMCA advisory board member, an active member of the St Peters Women's ACTS Team and a parishioner at San Fernando Cathedral where she serves as a Lector and an Extra Ordinary Minister of the Eucharist. This year she will be graduating with her Ph.D in Leadership Studies from Our Lady of the Lake University.


text:
MUSD gets special ed help
Former state sup faces some skeptics
Excerpts of news published in The Madera Tribune newspaper.
Former state sup faces some skeptics
Allegedly caused head-on crash
Authorities have released surveillance video that captured a man in West Hollywood making a purchase with stolen credit card information swiped from the 22-Mile House back in November.
FRESNO (AP) — Fresno is being sued by a group who claims the city did not perform a legally required environmental study before granting a new contract for trash collection.
Luncheon and raffle tickets are now available for Camarena Health's 19th annual scholarship fundraiser on Feb. 8.
Air National Guard airmen Alfredo J. Uribe and Moses D. Osuna graduated from basic military training at Lackland Air Force Base in San Antonio, Texas.
By Bernard Condon and Paul Wiseman, Associated Press Business Writers


text:
new year's wine box
- the story
A Box of Bubbly
Celebrate the arrival of a new year long after the dropping of the ball with this unique champagne or sparkling wine box. Carved from unfinished birch wood, this keepsake box provides beautiful way to present your new year's host or hostess with a celebratory bottle to be opened and shared with friends and family after the clock strikes 12. Each charming container is carved with the countdown and the iconic ball on it's exciting descent! The box's recipient will be greeted by the intimate tiding "Here's to a new year with good friend, good times and good intentions." Made in Kirkwood, Missouri. Wine not included.
Exclusively at UncommonGoods.
- details
- Item ID
- 21931
- Made from
- birch wood
- Measurements
- 14" L x 4.375" W x 4.5" H
- Notes
- A bottle of wine or champagne (3.625" wide and smaller)will fit in the box!
Care: Wipe clean with a damp cloth.
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Comments about NEW YEAR'S WINE BOX:
The photo hints the message is on the back of the box where is would be visible and a great add, but instead it is on the slat on the inside, where people might not look.
- Was this a gift?:
- Yes
- Who was the recipient of this product?:
- Husband
- For what occasion did you purchase this product?:
- Christmas or Hanukkah


text:
Corsair Obsidian 750D Case Review
Corsair launches a true successor to the venerable Obsidian 800D.42 by Dustin Sklavos on 9/24/2013
AMD Center Giveaway: HP ENVY Sleekbook, 15.6" quad-core Richland Notebooks
Earlier this month we launched the AMD Center, a portal on AnandTech that aggregates all of our AMD content in one place. As a recap, the AMD Center features...1226 by Anand Lal Shimpi on 9/23/2013
Microsoft Surface Event Live Blog
We're seated and inside at Microsoft's Surface event in New York City, where Microsoft will hopefully announce the upcoming Surface RT and Pro successors. We'll be live blogging away inside.85 by Brian Klug on 9/23/2013
ASUS MX299Q Monitor Review
The panel does not make the monitor. As I saw in my last 21:9 monitor review, even if you have the exact same panel in two displays, a whole...46 by Chris Heinonen on 9/23/2013
Capsule Review: EVGA GeForce GTX 780 Superclocked ACX
Today we'll be taking a quick look at EVGA's GeForce GTX 780 Superclocked ACX. A twist on tradition card for EVGA, the 780SC ACX is the company's standard first-tier...42 by Ryan Smith on 9/22/2013
SilverStone Precision PS07 Case Review Redux
We revisit SilverStone's mainstream micro-ATX enclosure to test its newest revision.32 by Dustin Sklavos on 9/20/2013
The iOS 7 Review
There's no doubt about it, this iOS update is one of the largest in Apple's history. In the wake of the iPhone 5 launch, there was a considerable amount...146 by Brian Klug & Saumitra Bhagwat on 9/19/2013
The iPhone 5s Review
For much of the iPhone's life Apple has enjoyed a first-mover advantage. At the launch of the first iPhone, Steve Jobs expected the device and OS would give it...466 by Anand Lal Shimpi on 9/17/2013
The iPhone 5c Review
For years now Apple has followed a rather intelligent waterfall of its products down the pricing stack. With the arrival of every new iPhone, the previous generation gets a...70 by Anand Lal Shimpi on 9/17/2013
Intel's Xeon E5-2600 V2: 12-core Ivy Bridge EP for Servers
The core architecture inside the latest Xeon is typically a step behind what you find inside the latest desktop and notebook chips. A longer and more thorough validation is...72 by Johan De Gelas on 9/17/2013
Alienware 18 Gaming Notebook Review
Alienware's deluxe model benefits the most from the refresh.61 by Dustin Sklavos on 9/16/2013
NZXT H230 Silent Case Review
The successor to the H2 arrives, but it breaks NZXT's winning streak.29 by Dustin Sklavos on 9/13/2013
The Bay Trail Preview: Intel Atom Z3770 Tested
Earlier this year Intel unveiled Silvermont, its first true architectural update to Atom since its introduction in 2008. I won't rehash Silvermont's architecture here, but it's designed to be...190 by Anand Lal Shimpi & Brian Klug on 9/11/2013
Apple's Town Hall iPhone Event Live Blog
Brian and I are at Apple's Campus today for the unveil of the next-generation iPhone. Check back here for the live blog that should start at 10AM PT.68 by Anand Lal Shimpi & Brian Klug on 9/10/2013
Analyzing the Price of Mobility: Desktops vs. Laptops
Computers have been getting faster over the years, and with the increased performance we eventually passed the point where most systems were "fast enough" and the various features and...110 by Jarred Walton on 9/7/2013
LG G2 and MSM8974 Snapdragon 800 - Mini Review
The LG G2 is the spiritual successor to the Optimus G, a device that we looked at last year and eventually went on to become the Nexus 4. LG...119 by Brian Klug on 9/7/2013
Alienware 17 Gaming Notebook Review
Prior to the Haswell generation, the Alienware M17x was the gaming notebook to get. The new Alienware 17 has a fresh coat of paint and a new moniker, but...46 by Dustin Sklavos on 9/6/2013
AMD Center Giveaway: Acer V5, 11.6" quad-core Temash Notebooks
Today we launched the AMD Center, a portal on AnandTech that aggregates all of our AMD content in one place. Thanks to AMD's sponsorship you'll get a cleaner interface...1265 by Anand Lal Shimpi on 9/5/2013
The Galaxy Gear Preview: Samsung's First Wearable
As the smartphone and tablet markets shift from high growth to the early stages of maturity, forward looking companies are looking at other adjacent markets for continued growth. Wearable...80 by Anand Lal Shimpi on 9/4/2013
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The SMB / SOHO / consumer NAS market is expected to experience good growth over the next few years. With declining PC sales and increase in affordability of SSDs...54 by Ganesh T S on 9/4/2013


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How much does it take to make a giant flag for the Pope? Brazilian group took on the challenge
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http://en.romereports.com It took over three months to make, and nearly 26000 square feet of material. In all, a total of 72 parishes, 18 schools and 11 rel...
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text:
Lincoln Industries Sourcing Engineer Interview Questions
Interview Experience
Interview Experience
Getting an Interview
Getting an Interview
Interview Difficulty
Interviews for Top Jobs at Lincoln Industries
- Intern (1)
- Safety (1)
- Sourcing Engineer (1)
- Vice President (1)
- Learning and Development (1)
- Manufacturing Engineer Intern (1)
1 Candidate Interview Review Back to all InterviewsSort: Popular Date Difficulty
Sourcing Engineer Interview
I applied online. The process took 1+ week – interviewed at Lincoln Industries (Lincoln, NE) in March 2012.
Applied for this position, got a call 10 days later requesting a phone interview. Phone interview was scheduled within the next few days. Phone interview was quite awkward, there were more questions pertaining to "About Me", "My Ideal workplace", and intrusive questions about why I left former employers for a new job. Very few questions about my former accomplishments, areas of expertise, familiarity with all of the different SAP, ERP, CAD, etc. systems that are in use.
What's wrong with this interview process:
1. I don't like to go on and on about myself when I'm interviewing for a job. It's just bad etiquette to say "I did this", or "I like this" during an interview. This is usually a mistake that the interviewee makes, not the interviewer.
2. My ideal workplace? I wouldn't have applied for the job if I hadn't done my research and found the company to be an ideal workplace for me.
3. Why I moved from one employer from another? Natural progression. We start out, move on to better opportunities, and keep trying to improve ourselves. (That is why I applied for the position).
At the end of the interview, I asked what kind of timeline there was for the position. I was told they were looking to fill the position immediately, and I would hear back from them in regards to the next steps.
I followed up with them after 1 week (They requested I keep them updated as to my interest) to inquire about the status of the interview process.
Did not receive a call back from them, and I feel like I held up my end by letting them know that I was interested.
After I didn't receive a call back, I started thinking about how they run their business. This was about 2 weeks after I tried to contact them.
In my opinion, the person doing the interviewing simply cannot perform the duties required for someone in that position. Good or bad, it would have been nice to hear back from them, as promised.
Interview Questions
- "So tell me about you" 1 Answer


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
31 year old woman | Jersey City, NJ, USA | Seeking men 25-38 within 20 miles
Active within 3 days
I run with scissors...
I decided to put myself out there and try something new. Seems to be the trend this year. I lived abroad for six months and after moving home for a little bit decided to move out here from Arizona. It has been a roller-coaster ride but I'm finding that I have an undiscovered adventurous side. I love to laugh so humor is huge! I'm a bit eccentric and goofy. Looking for someone who knows when to be serious but also has the ability to laugh at life or at themselves (which I seem to do quite a bit). If you want to get to know me, e-mail me. I'm not sure how I feel about this wink stuff ha, so it's probably best just to be straightforward.
Camping , Coffee and conversation , Dining out , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing cards , Playing sports , Travel/Sightseeing , Volunteering , Wine tasting
Basketball, Bowling, Dancing, Martial arts, Swimming
I exercise 3-4 times per week.
I have Dogs
I like Cats
I have a puppy named Monster
Middle of the Road
I love live music!
I love food - the end :O) . I have an eclectic taste in music.
Honestly I'm pretty open minded when it comes to what I like to do for fun. If you can introduce me to something new I'm all for it. It's easy to have fun when in good company!
Currently reading "The Alchemist" so far super impressed with the book and the message!
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'3" (160cms)
|5'8" (172cms) to 6'5" (195cms)
|Body type:
|Athletic and toned
|About average, Athletic and toned
|No preference
|No preference
|No Way
|No Way, Occasionally, Cigar aficionado
|Social Drinker
|Social Drinker
|Self-Employed / Entrepreneur
|No preference
|I'll tell you later
|$50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000, $150,001+
|Never Married
|Never Married
|Have kids:
|Wants kids:
|Definitely, Someday
|Asian, Other
|White / Caucasian, Other
I'm Korean and German.
|Christian / Catholic
|Christian / Catholic, Christian / Protestant, Christian / Other
I'm Christian and attend church occasionally. Faith is important to me and I'd like to meet someone who shares in the same values!
|English, Other
|Bachelors degree
|Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


text:
Manchester Indie Film Makers Group: Short Film Festival 2015
- Film, Media & Entertainment
- Performance Space, St. Peter's Square, Manchester, M2 5PD
BBC Get In event - Local Apprenticeship, BBC Radio Manchester
BBC Academy
Thursday, 8 May 2014 from 15:00 to 18:00 (BST)
e l Are you interested in finding out more about the BBC's new Local Apprenticeship Scheme?
Do you want to put your town on the map, while earning and learning and getting your career off to the best start possible?
Are you a non-graduate?
If the answer is "Yes" then come along to the BBC Academy's Get In event on 8 May 2014.
You will get to meet BBC Radio Manchester staff, get to know how BBC Local Radio works and how to apply for the BBC's newest and biggest apprenticeship scheme.
We will be able to answer all your questions including when applications will open, how to apply, what we're looking for and what to expect if you got a place on the scheme.
Book your ticket and tour now and join us Thursday 8 May 2014, pick from two time-slots between 3-7pm.
Places are limited to one per person so book now!
Some background…
The BBC is offering 45 paid apprenticeships in local radio stations across the UK as part of a pledge to open up the BBC to people from a wide range of backgrounds. Applications are open 14 April - 12 May 2014 and successful candidates will work and train as Apprentice Broadcast Assistants in local radio stations in England, Wales or Channel Islands and Apprentice Content Assistants in Scotland and N. Ireland.
We are looking for applicants who are:
Other events will be held elsewhere in the UK later in April.
Please note that we WILL NOT be discussing any other BBC apprenticeship schemes at this session as we have separate events planned for these later in the season.
Join millions of people on Eventbrite.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


text: This is this first book published in nearly twenty years that is specifically geared toward senior undergraduate and first year graduate students in advanced abnormal psychology courses. It begins with a rigorous description of basic concepts and models, and then details in-depth the major disorders and treatment strategies. Chapters include case studies where applicable, and are presented in identical formats to ensure consistency.


text:
"CigarCraig's Blog > Cigar Brothers, Wooden Indian, Cigar Mojo and the Fratello Bianco Toro http://goo.gl/fb/QhrGvd"
Bruce Bell has not received any gifts yet
Hi, hello and welcome! Here you will find fun, facts and friends. Sit back, relax, light up and enjoy!
Tell us something about yourself, your passion for cigars…
Welcome to our smoky abode, Bruce. Any particular favorites that come to mind?


text:
Aging is not 'lost youth' but a new stage of opportunity and strength. Betty Friedan
Beware of the young doctor and the old barber. Benjamin Franklin
At twenty years of age the will reigns; at thirty the wit; at forty the judgement. Benjamin Franklin
Young people are in a condition like permanent intoxication, because youth is sweet and they are growing. Aristotle
You can only perceive real beauty in a person as they get older.
Anouk Aimee
Growing old is no more than a bad habit which a busy man has no time to form. Andre Maurois
As we grow old the beauty steals inward. Ralph Waldo Emerson
A man of genius is privileged only as far as he is genius. His dullness is as insupportable as any other dullness. Ralph Waldo Emerson
Never take action when youare angry. Priya Arora
Skip one meal a week and give what you would have spent to a homeless person. Priya Arora
Dont postpone joy.
Priya Arora
Complement three pople everyday. Priya Arora
Make the best of bad situation.
Priya Arora
Use your partner to amuse,not abuse. Priya Arora
In business and family relationships, remember that most important is trust. Priya Arora
An error doesn't become a mistake until you refuse to correct it. Sanchi
If you wish another to keep your secret,first keep it yourself. Manjusha Aggarwal
If u r not big enough to lose, u r not big enough to win. Neetu
It is very important to get a understanding & loving life partner in life, otherwise your life is ruined & finished Amandeep Singh
Don't undermine ur worth by comparing urself with others. its b'coz we are differnt that each of us is special. Neetu


text:
2 bed, 1 full bath. great investment property , 2 floors 2 bedrooms upstairs ,living-dinning kitchen downstairs , niceMore info
2 bed, 1 full bath. INVESTOR WELL KEEP UNIT, RENTED FROM SECTION 8 FOR $1100More info
2 bed, 2 full bath. NICE CONDO TO LIVE IN LOCATED IN A GOOD AREA. COMMUNITY IS A 55 AND PLUS NICE CARYOUT. LARGE BEDROOMore info
2 bed, 1 full bath. Great Investment potential. In the heart of South Miami. Currently tenant occupied. Do not disturbMore info
4 bed, 3 full bath. Investor's Dream! Two story Townhouse with large backyard and fence. Beautiful and spacious 4 bedroMore info
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text:
Basketball: North JV boys fall short
Published: Thursday, November 29, 2007 at 2:33 a.m.
Last Modified: Thursday, November 29, 2007 at 12:00 a.m.
North Davidson's junior varsity boys mounted a furious rally after falling behind by 20 points but could not climb all the way back, dropping a 48-46 decision to Page on Wednesday in Welcome.
Joe Farrell had 11 points and Jerry Houpe added nine for the Black Knights, who dipped to 2-1. North visits Ledford on Friday.
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text:
YIELD: Makes 36 desserts
Make purée:
In a small heavy saucepan simmer purée ingredients, covered, 10 minutes. In a food processor purée mixture until smooth. Purée may be make 1 week ahead and chilled, covered.
Make brandied cream:
In a small bowl fold brandy and sugar into whipped cream and chill, covered.
Transfer purée and brandied cream to separate pastry bags fitted with 1/4-inch star tips. Pipe cream into shells until level with tops and pipe a 1/2-inch-high mound of purée on top.
Sprinkle desserts with confectioners' sugar and garnish with almonds.