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On Wednesday, exactly a week since he was crowned an "American Idol" champion, Scotty McCreery told MTV News all about the plans for his debut album (and his thoughts on the whole "Country Bieber" thing, and it should probably come as no surprise to learn that he's not planning on straying too far from his roots.
"It's gonna be a good ol' country album," McCreery said. "I like to have that old flavor in my music, but with a contemporary feel, so we'll see where that leads me. I think it'll a good little mix."
But, of course, it won't just be McCreery releasing a post-"Idol" album: runner-up Lauren Alaina is already prepping her debut disc. And, if you watched the preternaturally perky belter during her time on the show, well, you can probably guess how her debut will sound.
"We're country kids, so we're gonna make country albums," she said. "I'm definitely going to have a country album, and if it crosses over, that would be great, but I like new, upbeat songs that people can dance to and sing along to, so, yeah, that's where I'm headed, hopefully."
So for those keeping track, that's two country albums coming your way soon. And, in keeping with grand "Idol" tradition, both McCreery and Alaina will begin work on their albums during the American Idols Live! Tour , a task, given their young ages, that would seem to be pretty daunting. But, as it turns out, they've actually gotten used to the grind; in fact, it started way back during their time in the ill-fated "Idol" mansion.
"I write my own music, I really like to write," Alaina said. "Scotty and I were actually writing a song together back when we were living in the mansion."
"We're heading on tour and we're going to be recording our albums when we're out on tour, and it's going to be a busy time," McCreery added. "But we're going to do our best to get the music out to you as soon as possible."
Get your "Idol" fix on MTV News' "American Idol" page , where you'll find all the latest news, interviews and opinions.


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Innisbrook Village Apartments
3668 McConnell Road, Greensboro, NC
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About Innisbrook Village Apartments
Imagine coming home to a relaxing atmosphere with luxurious amenities available at your fingertips. Enjoy the comfort of your apartment home, equipped with high gloss black appliances, granite-style counter tops, premium hardwood cabinetry, relaxing garden tubs, chef-inspired kitchens & more! Innisbrook Village is conveniently located moments from casual & fine dining, shopping at Four Seasons Mall & Friendly Center, entertainment in exciting Downtown Greensboro and a short commute to Burlington.
As you search for your perfect apartment, please keep in mind that rental rates (including specials and discounts) and availability are very fluid in the apartment industry. Based on many factors, the rental rates (including specials and discounts) and availability can actually change not just daily, but hourly, if not even more quickly. While our advertisers do take steps to keep their information current, the rental rates or availability you may find here now at ForRent.com may not be the same as when you contact the communities.

subset: commoncrawl


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Griffin Technology (http://www.griffintechnology.com) has debuted iTrip DualConnect (pictured) and TuneFlex AUX HandsFree, their latest in-car creations for iPhone and iPod.
The US$59.99 iTrip DualConnect combines Griffin's FM transmitter technology with an AUX jack for direct connection to car stereos equipped with auxiliary-input jacks. You can connect your iPhone or iPod touch through iTrip directly to your car stereo, or use iTrip's FM transmitter to send the music wirelessly to your car radio. Either way, the illuminated buttons on iTrip's charger plug give you play, pause, forward, and backward track controls that you can operate distraction-free by touch while driving.
You can download the free iTrip Controller App for setup and operation of iTrip's FM transmitter through your Multi-Touch display. To get started, just press iTrip's SmartScan button, then tune your car radio...| Read more »


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3286 Malcolm Avenue
Palms, Los Angeles, 90034
Commute to Downtown Culver City
Some errands can be accomplished on foot.
A few nearby public transportation options.
Steep hills, some bike lanes.
Score Details
3286 Malcolm Avenue has a Walk Score of 63 out of 100. This location is Somewhat Walkable so some errands can be accomplished on foot.
This location is in the Palms neighborhood in Los Angeles. Nearby parks include Palms Park, Mar Vista Recreation Center and Mar Vista Recreation Center.
Explore how far you can travel by car, bus, bike and foot from 3286 Malcolm Avenue.
3286 Malcolm Avenue has some transit which means a few nearby public transportation options. Car sharing is available from RelayRides.
Bus lines:
R12 Rapid 12 National Bl- Ucla
0.2 mi
12 Ucla - Palms - Robertson Blvd
0.3 mi
8 Ocean Park Blvd - Ucla
0.4 mi
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3286 Malcolm Avenue compared to all of Los Angeles.
Lower crime area.
Lower crime area.
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3286 Malcolm Avenue is in the Palms neighborhood. Palms is the 14th most walkable neighborhood in Los Angeles with a neighborhood Walk Score of 79.
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Dolly Parton Offers Advice On How To Stay Cool This Summer [VIDEO/POLL]
Summer is not officially here yet but musical icon Dolly Parton has some great advice on how to stay cool this summer.
Summer is not officially here yet but musical icon Dolly Parton has some great advice on how to stay cool this summer.
School is coming to an end for most students all across the country and a recent Cal State graduate Rocio Almaraz and some fellow graduates thought it would be a surprise to everyone in attendance if they planned a flash mob dance. But Rocio was the one who got the biggest surprise of all.
If you're like me you grew up watching Star Trek and really got into the characters who made that 1960s show an iconic success. The engineer Scotty was played by actor James Doohan and one of his famous lines out of the show, I recall was "I'm Giving it All She's Got Captain."
So they held the elections for the Texarkana College Board, and the two candidates running for place 2 ended up in a tie. Now what?
Movies in the Park continues at Spring Lake Park Thursday, May 24, presented by the City of Texarkana, Texas Parks and Recreation.
Well, this Tuesday, May 21, American Idol finalists Jessica Sanchez and Phillip Phillips will battle it out to see who gets crowned this year's American Idol.
George Strait has literally hundreds of songs in his vast catalog, but in honor of his 60th birthday today (May 18), we're asking you the impossible: What is your favorite George Strait song? Trust us, we know — the possibilities are endless. Yet somehow, we've narrowed it down to just five choices.
In a bizarre story from Bloomfield, Pa., a pizza shop owner says he's caught evidence of an angel from his security camera outside the store.
ABC's 'Dancing With The Stars' results will feature country superstar Carrie Underwood performing her latest single "Good Girl" from her current album "Blown Away."
This weekend Railfest 2012 is set for Saturday, May 12 and Sunday May, 13 in the Front Street Plaza, Downtown Texarkana. In addition to everything going on this weekend it's the 35th Anniversary of the iconic movie Smokey and the Bandit, and the 6th year of the Bandit Run by Restore a Muscle Car and by Main Street Texarkana.
Ever had the nightmare of losing your luggage when flying? I guess my fear is not flying, it's losing your luggage that would make me mad. I was talking to a guy one day at the airport and asked him what do they do if they can't locate the person who lost their luggage. He said, probably will wind up at the Unclaimed Baggage Center in Alabama.


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I have 3 gran children and I swear I don't look a day over 40? 50? Maybe? The main thing is that I feel young and that's all that count's.
I'm afraid that one day I'm gonna wake up and find that I grew up. You no there's something to be said about not feeling so grown up or mature even at this age. I think that's the secret to a youthful spirit.
I moved to Washington from Calif. What I found here is something very special to me. This place can move you with it's beauty and splendor. I feel some weird kind of spiritual connection that I haven't felt since growing up in the woods of South Lake Tahoe.
I'm hoping to find someone local to show me the back woods and some cool places to hike and fish.
That's a small taste of who I am!


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Recent Posts »
Bruce Springsteen perfoming at halfime of Super Bowl
Page Six says that "The Boss" himself will be performing at next years Super Bowl in Tampa. "Super Bowl XLIII on Feb. 1 in Tampa will feature Bruce Springsteen and the E Street Band,Read More »
Balls to the face
TheBeautifulGame has video of a wayward shot on goal in the Heidenheim vs. Wolfsburgthat game that flies into the stands and decks a young cheerleader in her face. That was unexpected and definitely hurt.Read More »
Caption This
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Spain slants their eyes in pre-Olympic ad
Not sure what the Spanish national basketball team meant by this, but it doesn't look right to me. "The advertisement features two large photographs, one of the men's basketball team, below, and one ofRead More »
Olympic Swimming: 4x100m Freestyle Finish
I am a sucker for the Olympics and if you can't get into it after watching the United States swim team come back and beat the trash-talking French then I don't get you. GoosebumpRead More »
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 Our search for the biggest douchebag in sports rolls on. First, review our first 9 nominees. Candidate 10: Ted NolanRead More »
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The Douchewheel rolls on. Review our first 8 candidates. Done? Good. Let's move on to number 9. He's small in stature, but dominant in douchiness. Candidate number 9: Isiah ThomasRead More »
Terrell Owens and Three 6 Mafia interview each other
Cousins of Ron Mexico was right. I did enjoy "Adventures in Hollyhood," so why wouldn't I like this video interview of Terrell Owens and Three 6 MafiaRead More »


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Article posted Jan 09 2006, 8:26 PM
Tyranny/Police State
Bush Advisor Says President Has Legal Power to Torture Children
John Yoo publicly argued there is no law that could prevent the President from ordering the torture of a child of a suspect in custody – including by crushing that child's testicles.
This came out in response to a question in a December 1st debate in Chicago with Notre Dame professor and international human rights scholar Doug Cassel.
What is particularly chilling and revealing about this is that John Yoo was a key architect post-9/11 Bush Administration legal policy. As a deputy assistant to then-Attorney General John Ashcroft, John Yoo authored a number of legal memos arguing for unlimited presidential powers to order torture of captive suspects, and to declare war anytime, any where, and on anyone the President deemed a threat.
It has now come out Yoo also had a hand in providing legal reasoning for the President to conduct unauthorized wiretaps of U.S. citizens. Georgetown Law Professor David Cole wrote, "Few lawyers have had more influence on President Bush's legal policies in the 'war on terror' than John Yoo."
This part of the exchange during the debate with Doug Cassel, reveals the logic of Yoo's theories, adopted by the Administration as bedrock principles, in the real world.
Cassel: If the President deems that he's got to torture somebody, including by crushing the testicles of the person's child, there is no law that can stop him?
Yoo: No treaty.
Cassel: Also no law by Congress. That is what you wrote in the August 2002 memo.
Yoo: I think it depends on why the President thinks he needs to do that.
The audio of this exchange is available online at revcom.us
Yoo argues presidential powers on Constitutional grounds, but where in the Constitution does it say the President can order the torture of children ? As David Cole puts it, "Yoo reasoned that because the Constitution makes the President the 'Commander-in-Chief,' no law can restrict the actions he may take in pursuit of war. On this reasoning, the President would be entitled by the Constitution to resort to genocide if he wished."
What is the position of the Bush Administration on the torture of children, since one of its most influential legal architects is advocating the President's right to order the crushing of a child's testicles?
This fascist logic has nothing to do with "getting information" as Yoo has argued. The legal theory developed by Yoo and a few others and adopted by the Administration has resulted in thousands being abducted from their homes in Afghanistan, Iraq or other parts of the world, mostly at random. People have been raped, electrocuted, nearly drowned and tortured literally to death in U.S.-run torture centers in Afghanistan, Iraq, and Guantánamo Bay. And there is much still to come out. What about the secret centers in Europe or the many still-suppressed photos from Abu Ghraib? What can explain this sadistic, indiscriminate, barbaric brutality except a need to instill widespread fear among people all over the world?
It is ironic that just prior to arguing the President's legal right to torture children, John Yoo was defensive about the Bush administration policies, based on his legal memo's, being equated to those during Nazi Germany.
Yoo said, "If you are trying to draw a moral equivalence between the Nazis and what the United States is trying to do in defending themselves against Al Qauueda and the 9/11 attacks, I fully reject that. Second, if you're trying to equate the Bush Administration to Nazi officials who committed atrocities in the holocaust, I completely reject that too…I think to equate Nazi Germany to the Bush Administration is irresponsible."
If open promotion of unmitigated executive power, including the right to order the torture of innocent children, isn't sufficient basis for drawing such a "moral equivalence," then I don't know what is. What would be irresponsible is to sit by and allow the Bush regime to radically remake society in a fascist way, with repercussions for generations to come. We must act now because the future is in the balance. The world cannot wait. While Bush gives his State of the Union on January 31st, I'll find myself along with many thousands across the country declaring "Bush Step Down And take your program with you."
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Tyranny/Police State
Cop Tells Woman There's "No Excuse" For Parking The Wrong Way, Says It's Against The Law To Film Him
NYPD Cops Terrified of New Bills that Will Stop them from Choking and Illegally Searching People
Cop Kills Man with Patrol Car While Speeding & Looking at Laptop, Flexes Blue Privilege – No Charges
TSA Asks America To LOL At Traveler Who Had $75,000 Taken From Him By Federal Agents
War Veteran with PTSD Faces Life in Prison for Pot, His Wife Calls for Help
No Charges Against Cops That Killed 17-Yr-Old Kristiana Coignard
This Week's Corrupt Cops Stories
Judge Orders Lying, Cheating Government To Return $167,000 To The Man They Stole It From
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text: Publications Search Results Users may wish to consult What's Included in the Bibliography. Results 1 - 2 Results per page: 25 50 100 Sort by: Pub Date (newest) Title Recent Additions Author Clear All Pub. Year Citation 2008 De Leon, G., Melnick, G., Cleland, C.M. . Client matching: A severity-treatment intensity paradigm. Journal of Addictive Diseases. 27, (3), 99-113. Full Text Options: DOI Worldcat Google Scholar Export Options: RIS EndNote XML 2014 Khan, M.R., Cleland, C.M., Scheidell, J.D., Berger, A.T. . Gender and racial/ethnic differences in patterns of adolescent alcohol use and associations with adolescent and adult illicit drug use. American Journal of Drug and Alcohol Abuse. 40, (3), 213-224. Full Text Options: DOI Worldcat Google Scholar Export Options: RIS EndNote XML [1]


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How to cite this article: Angkustsiri K, Wirojanan J, Deprey LJ, Gane LW, Hagerman RJ. 2008. Fragile X syndrome with anxiety disorder and exceptional verbal intelligence. Am J Med Genet Part A 146A:376–379.
Clinical Report
Fragile X syndrome with anxiety disorder and exceptional verbal intelligence†
Article first published online: 17 JAN 2008
DOI: 10.1002/ajmg.a.32118
Copyright © 2008 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 146A, Issue 3, pages 376–379, 1 February 2008
Additional Information
How to Cite
Angkustsiri, K., Wirojanan, J., Deprey, L. J., Gane, L. W. and Hagerman, R. J. (2008), Fragile X syndrome with anxiety disorder and exceptional verbal intelligence. Am. J. Med. Genet., 146A: 376–379. doi: 10.1002/ajmg.a.32118
- †
Publication History
- Issue published online: 25 JAN 2008
- Article first published online: 17 JAN 2008
- Manuscript Accepted: 23 AUG 2007
- Manuscript Received: 8 NOV 2006
Funded by
- NICHD. Grant Numbers: HD036071, HD02274
- NINDS. Grant Number: NS044299
- Center for Disease Control and Prevention. Grant Number: U10/CCU925123
- Abstract
- Article
- References
- Cited By
- fragile X syndrome;
- anxiety disorder;
- verbal intelligence
Fragile X syndrome (FXS) is often characterized by mental retardation. However, FXS is also associated with significant emotional and psychiatric problems, including anxiety, depression, attention difficulties, and learning disabilities in the presence of a normal IQ. This report describes a unique woman with the full mutation of FXS who has an exceptional profile of above-average intelligence combined with significant impairments due to anxiety and learning disability. Women with FXS can present primarily with learning and emotional problems, and clinicians should consider FXS in these women regardless of their IQ. © 2008 Wiley-Liss, Inc.


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Calera Pinot Noir Jensen Vineyard 2011
Calera - California - United States - San Benito County - Mount Harlan
Professional Wine Reviews for Calera Pinot Noir Jensen Vineyard 2011
Rated 93 by Robert Parker
Beautifully complex, Jenson's 2011 Pinot Noir Jenson Vineyard offers a lively, fresh feel in its sweet cherry, strawberry, sappy spring flowers and subtle mint-driven bouquet. Medium-bodied, layered and seamless, it's an elegant and silky example of this cuvee to drink over the coming decade or more.
Rated 91 by Wine Spectator
This offers aromas of dried herb and pennyroyal, with a compelling core of dark berry flavors, showing dried currant, cranberry and black licorice notes. Gains depth and length on the...
read more...
Professional Wine Reviews for Calera Pinot Noir Jensen Vineyard 2011
Rated 93 by Robert Parker
Beautifully complex, Jenson's 2011 Pinot Noir Jenson Vineyard offers a lively, fresh feel in its sweet cherry, strawberry, sappy spring flowers and subtle mint-driven bouquet. Medium-bodied, layered and seamless, it's an elegant and silky example of this cuvee to drink over the coming decade or more.
Rated 91 by Wine Spectator
This offers aromas of dried herb and pennyroyal, with a compelling core of dark berry flavors, showing dried currant, cranberry and black licorice notes. Gains depth and length on the finish. Drink now through 2023.
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Additional Information on Calera Pinot Noir Jensen Vineyard 2011
Vintage: 2011
The year 2011 was an interesting year for many northern and central European countries, as the weather was more than unpredictable in the spring and summer. However, in most countries, the climatic conditions thankfully settled down in the late summer and fall. The result of this slightly difficult year of weather in France was a set of surprisingly small yields, but overall, these yields were of a higher quality than those harvested in certain previous years. A fantastic set of wines was also made in Italy and Spain, and the Rioja wines - when released - are set to be very good indeed. Austria also had superb year in 2011, with almost fifty percent more grapes being grown and used for their distinctive Gruner Veltliner wines than in the year before. Possibly the European country which had the finest 2011, though, was Portugal, with wineries in the Douro region claiming this year to be one of the best in decades for the production of Port wine, and the bright, young Vinho Verdes wines. In the New World, the Pacific Northwest saw some of the best weather of 2011, and Washington State and Oregon reportedly had a highly successful year, especially for the cultivation of high quality red wine grapes. Chile and Argentina had a relatively cool year, which certainly helped retain the character of many of their key grape varietals, and should make for some exciting drinking. South Africa had especially good weather for their white wine grape varietals, particularly Chardonnay and Sauvignon Blanc, and many South African wineries are reporting 2011 as one of their best years in recent memory.
Varietal: Pinot Noir
Pinot Noir is one of the planet's most widely grown and enjoyed grape varietals, and thanks to the popularity of the key wines it is associated with – Burgundy and Champagne – it has successfully spread from its native home in France to much of the wine producing world. Pinot Noir means 'black pine' in French, and this refers to the extremely dark, inky color of the fruit, and the fact that it grows in conical bunches, resembling a large pine cone. It has long been revered for its wide range of refreshing, summery flavors, and the fact that it produces red wines of a beautiful garnet color and light body. More recently, sparkling wines made exclusively with Pinot Noir have been extremely popular, and the orchard notes found in the fizzy 'blanc des noirs' wines mark out just how versatile this grape varietal really is. Despite being notoriously difficult to grow, it isn't hard to see why this grape is now found in vineyards all over the world, as it is synonymous with romance and decadence, quality and fantastic flavor
Region: California
California has long been the New World's most important and prodigious wine producing regions, with a history which stretches back to the 18th century and the Spanish pioneers who settled here. Today, California produces vast quantities of wine, and if it were a country, it would be the fourth largest producer of wine on earth. Despite experiencing many problems in the mid 20th century, including a very serious blight which almost crippled the state's wine industry, the ideal terroir and excellent climate ensured that Californian wines soon became the envy of the New World once again. California produces a vast range of wines, and utilizes a long list of fine grape varietals, with many wineries and their produce more closely resembling those of France and other Old World countries in regards to character, practices and flavors
Country: United States
Of all the New World wine countries, perhaps the one which has demonstrated the most flair for producing high quality wines - using a combination of traditional and forward-thinking contemporary methods - has been the United States of America. For the past couple of centuries, the United States has set about transforming much of its suitable land into vast vineyards, capable of supporting a wide variety of world-class grape varietals which thrive on both the Atlantic and the Pacific coastlines. Of course, we immediately think of sun-drenched California in regards to American wines, with its enormous vineyards responsible for the New World's finest examples of Cabernet Sauvignon and Merlot based wines, but many other states have taken to viticulture in a big way, with impressive results. Oregon, Washington State and New York have all developed sophisticated and technologically advanced wine cultures of their own, and the output of U.S wineries is increasing each year as more and more people are converted to their produce.
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Employment Opportunities
High School Students: Do you love being outside? Enjoy doing something different every day? Have a passion for the environment?
The Student Conservation Corps is hiring high school students for spring and summer work sessions to remove invasive species from Parks and Land Trust properties. Read on to find out more!
Spring Break Scotch Broom Brigade applications are no longer being accepted. However, you may still submit application for Summer 2015 SCoCo sessions!
Salary information:
All SCoCo members will be paid $9.49, for four hours a day in each session. One hour of unpaid break time is dedicated to conservation education during the summer session and Corps members are expected to stay on site to participate.
Application process:
Interested individuals must attend an Application Work Party and submit an application for the Spring Break Scotch Broom Brigade or Summer SCoCo Sessions. The SCoCo members commit to a full BIMPRD summer session and two additional fall volunteer work parties. Up to 12 interested students from these 24 may participate in the spring break program.
Second Wave SCoCo Application Dates
Application work parties are now complete. If you are still interested in SCoCo but have not attended an application work party, e-mail Clarice Cutler at firstname.lastname@example.com.
BIMPRD SCoCo Session: June 22nd to July 8th. 9:30 am-2:30 pm:
The Program will run for 12 work days with holidays on weekends and July 4th. Field work will take place at two or more parks.
Bainbridge Island Land Trust SCoCo Session: July 13th to 17th. 9:30am-2:30pm:
This program is open to Summer Session SCoCo members as an optional extended work opportunity. Field work will take place at 2 or more sites that may include private Conservation easements in addition to Land Trust owned open space. There is also an opportunity for more days beyond July 17th for interested students.
You can also find upcoming work party information on SCoCo's
Facebook page
If you have more questions and interested in knowing more about the 2015 SCoCo program, please contact Clarice Cutler at firstname.lastname@example.com or Becca Nissley at (206) 842-1216 or firstname.lastname@example.com.
Copyright © 2007-2015 Bainbridge Island Land Trust
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Malala Chats With Jon Stewart, Utterly Amazes Him (& Us)
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Women have done a lot of things through the years in order to fight for their country: served in thankless behind-the-scenes jobs, dressed up as men, kept things going on the home front, and waited forever for the armed forces to allow women on the front lines. Some women of the Soviet Union during World War II went to the read
Kim Kardashian gets hit with a lot of nasty vitriol about pretty much everything – her career, her fashion choices, her parenting decisions, even her Instagram edits — the last of which prompted the famous "Can I live?" tweet. But this is particularly egregious. Based on this photo, it looks like someone took a still read


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Anime Expo - July 2nd - July 5th, 2015
- Film, Media & Entertainment
- 1201 South Figueroa Street, Los Angeles, 90015
NASM Personal Fitness Workshop
National Academy of Sports Medicine
Sunday, December 2, 2012 from 7:30 AM to 5:00 PM (PST)
Personal training is a growing industry and NASM wants to provide you with an opportunity to explore the details behind the success of our Certified Personal Trainer (CPT) certification. After completing this workshop, you will be able to identify the levels and phases of the OPT Model, the integral foundation of all of our evidence-based programming. You will also be able to understand the benefits and importance of an integrated training approach and understand how to implement Stabilization, Strength and Power Training with regard to all components of the workout including flexibility, core, balance, reactive, cardiorespiratory, and resistance trainings to effectively design programs based on goals, needs and wants assessments.
Call 1.877.654.0065 to register or go to: www.nasm.org/workshops
Workshop Cost: $199.00
Since 1987, the National Academy of Sports Medicine (NASM) has been a global leader in providing evidence-based certifications and advanced credentials to health and fitness professionals. It is part of Ascend Learning, a leader in providing technology-based educational, assessment, testing and certification solutions for healthcare and other vocational fields.
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Investors Still Jittery Despite Jobs Report
Investors Still Jittery Despite Jobs Report
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Weak Economy Still Struggling to Create Jobs
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Eric & Teresa Hartung's Profile
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Sassafras Inn Bed & Breakfast (Memphis Area)
Located just 22 miles from Memphis's Beale Street and 14 miles from Graceland. Enjoy an indoor pool and Jaccuzi. Choose from three unique Guest Rooms, or the "Heart's Content Cottage". Ideal for a romantic vacation, honeymoon or anniversary.
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Not only did Ana help me discover a world of green vegetables I had never known before, I learned that I can push myself far beyond what I ever thought was possible both mentally and physically. Working with Ana transformed my body and soul. She helped me learn to love and respect my body, something I had never been able to do before. All of this while sharing deep belly laughs that hurt so much we cried. I will be eternally grateful for her support, guidance, friendship, and genuine approach. Ana is truly unique - someone whom I aspire to - and I'm a better woman for knowing her.
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Book your room at North Coast Holiday Parks Ferry Reserve
Please enter your travel dates.
Get an overview of this hotel4-star family-friendly caravan park/campground in Brunswick Heads
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
Located on the waterfront, this family-friendly caravan park/campground is 7 mi (11.2 km) from Tyagarah Nature Reserve and 10.6 mi (17.1 km) from Belongil Beach. Wategos Beach and Cape Byron Lighthouse are also within 16 mi (25 km).
Property Features
Along with WiFi in public areas, this caravan park/campground has self parking and laundry facilities. Additionally, tour/ticket assistance, a convenience store, and a garden are onsite.
Room Amenities
Accommodations provide kitchens with refrigerators, stovetops, microwaves, and dishwashers. Free WiFi and balconies are standard, as are TVs with digital channels.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
North Coast Holiday Parks Ferry Reserve features tour/ticket assistance, barbecue grills, and a garden. Public areas are equipped with high-speed wireless Internet access (surcharge). This family-friendly caravan park/campground also offers a picnic area, laundry facilities, and a grocery/convenience store. Onsite parking is available (surcharge).
- Barbecue grill(s)
- Front desk (limited hours)
- Grocery/convenience store
- Tours/ticket assistance
- WiFi (surcharge)
- Laundry facilities
- Garden
- Picnic area
- Self parking (surcharge)
- Free parking nearby
Family Friendly Amenities
- Family Hotel
- Free Wi-Fi
- Kitchen
- Grocery/convenience store
- Laundry facilities
- Refrigerator
- Microwave
Available in all rooms: Free WiFi
Available in some public areas: WiFi (surcharge)
Self parking (surcharge), Free parking nearby
Room Amenities
- Premium TV channels
- Balcony
- Ceiling fan
- Air conditioning
- Refrigerator
- Coffee/tea maker
- Kitchen
- Microwave
- Shower only
- Hair dryer
- Iron/ironing board
- Television
- Cribs/infant beds available
- Dishwasher
- Stovetop
- Digital TV service
- Free WiFi
- Cookware, dishware, and utensils
Nearby Things to Do
The recreational activities listed below are available either on site or nearby; fees may apply.
- Kayaking nearby
- Snorkeling nearby
- Surfing/boogie boarding nearby
- Hiking/biking trails nearby
- Ecotours nearby
- Basketball on site
- Fishing on site
- Motor boating on site
- Rowing or canoeing on site
- Boat tours nearby
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible parking
- In-room accessibility
Hotel Policies
Check-in time starts at 2 PM
Minimum check-in age is 18
Check-in time ends at 6 PM
Special check-in instructions:
Check-out time is 10 AM
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
National Rating
Official Australia STAR Rating provided by Star Ratings Australia
Star Ratings Australia assigns an official STAR Rating for accommodations in Australia. This Caravan-Holiday Parks property is rated 4.0 stars.


text: To aid the U.S. Marshal service in raising funds for those who were left behind, and to honor those that died in the line of duty. Join us at Beckett's for a night of great music and activities with tunes from the U.S. Marshal pipe band and Aine O'Doherty. 50/50 raffle


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- Jul 25th - 26th, 2015
- Saturday 9:00am – 5:00pm
- Sunday 9:00am – 3:00pm
The Overland Park Gun Show will be held on Jul 25th - 26th, 2015 in Overland Park, Kansas. This Overland Park gun show is held at Overland Park International Trade Center and hosted by US Weapon Collectors of Kansas. All federal, state and local firearm ordinances and laws must be obeyed.
400 Tables
$56.00 EA Prepaid
Electricity $85.00
Dealer Setup:
Fri 12:00PM-7:00PM
Sat 7:30AM-8:30AM


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Professor Andrea CarrollFaculty
"We went through a total renovation, coincidentally, in the three years between the time I graduated and came back as a faculty member. The physical facilities were upgraded 100%, and now there's technology in all the classrooms."
For detailed information concerning LSU Safety Regulations, please consult the following sites:


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Fair Food!
- Uploaded By lisaturtle76
- 2012-09-14 04:25:24
I made this for the local fair.. I came in first place :) everything is made from fondant and rice krispie treats.. the popcorn box is cake tho. The two sticks are the only things that aren't edible!
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Water & Wastewater Companies in Georgia
Category: Water & Wastewater ×
Employees number: 11-100 ×
Industry: Oil, Gas & Refineries ×
Location: Asia & Middle East ×
Location: Georgia ×
based in Guelph, ONTARIO (CANADA)
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based in MORANGIS, FRANCE
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based in Topeka, KANSAS (USA)
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Flash Summit drives memory innovation
Posted: 12 Aug 2014 Print Version
Keywords:Flash Memory Summit DRAM NAND SSD[Summary of tips] I got a view of new uses for flash controllers, the significance of the still invisible Samsung V-NAND, and the long road ahead for next-generation non-volatile memory.Those were my highest peaks at the Flash Memory Summit. I also caught up on the battle over the DRAM bus and the race to pack ever more data into solid-state dri......
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Fun ways to show your American pride on the Fourth
5 ways to get over your ex in a flash
USA wins Women's World Cup!
Exclusive: Teen Beach 2 stars tell all about their thoughts on the movie
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Beauty Spy: GL reader Anna I. shares her pretty, natural makeup routine
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Have you ever been bullied? Share your story to help other girls!
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09 Apr 14
Latest David Beckham Leads
07 Mar 14
MLS Just as Popular as Baseball with American Kids According to a New Poll
Huge declarative statements to be made!
14 Feb 14
Roundup: Farts Prompt Prison Inmate Assault; Climbing Shanghai Tower; Happy Birthday Gheorghe Muresan
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David Beckham Wants to Own an MLS Team in Miami, Is It a Good Move for the League?
First underwear model team owner in sports?
02 Oct 13
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Former Manchester United coach gives long interview with Charlie Rose.
01 Oct 13
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Retired English star close to become MLS owner.
12 Sep 13
Romeo Beckham Signed For Arsenal Youth Academy
If he inherited his dad's right foot…


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SPECIAL OFFERSee details
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- Overview
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Do You Have the Right To Be Forgotten?
7 January 2015
The 'Right To Be Forgotten' brings up Privacy Issues - do want to have the right to remember?
Best of 2014: No 9: The Semantic Web: Business Models from a Marketing Perspective
5 January 2015
Why should you structure and share more data than just your Rich Snippet data? Read about multiple ways to commercially exploit the possibilities of the Semantic Web.
Best of 2014: No 10: 10 lessons I've learned from (nearly) 10 years of running an agency
5 January 2015
Quite a few friends of mine have started their own agency recently and asked for advice. This post outlines 10 lessons i wish i knew before i started MediaVision.
Locate Your Audience in Minutes with Google Fusion Tables
17 November 2014
Reach your customers where they are by using accurate geographic location targeting. In this post Polly Pospelova shows how to visualise customers postcodes on a Google Map in minutes.
Keeping a Young Mind in a Fast Changing Digital Market Place
10 November 2014
In a quickly changing digital industry it can be hard to keep a young mind. But you can. Here's how Bas van den Beld does it.
Fighting the Fear
3 November 2014
People are held back by fear. It is not real but it can still prevent us from achieving our goals. Find out how to embrace fear and achieve success.
How to stay Anonymous Online
29 September 2014
A lot of people have no idea how public it is what they do. And they also have no idea to protect their privacy. Here's how to get a...
Defining and Responding to Digital Relationships
16 September 2014
Understanding digital relationships with stakeholders and building those is part your job. Have you thought about the types of relationships you have?
Putting The Pink in the Aisle – More Women in Tech
5 August 2014
Does the digital industry suffer from a lack of female representation? Claire Thompson explores the issue and highlights some aspects of the debate.
25 June 2014
With every new service it launches, Google increases its stranglehold on the entire world wide web to become the definitive end destination online.


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ICECREAM Classic Repeat Red T-Shirt
Item # 211773
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The Top 10 In Action Sports
01Brick By Brick: Camping Lego Style
02Booze and Bikes: 14 Tours That Let Combine Two of the Best Things in the World
03Who Needs Hollywood? These Incredible Videos Were All Filmed on the Simplest Cameras
04Sam Pilgrim vs. The World: The Champion Aiming To Reclaim His Crown In A New Era Of Biking
05Eccentric Adventures Episode 2: Britain's Most Brutal Illegal Event is All About Cheese
06A Journey Into Darkness: We Went Mountain Biking in the Abandoned Mines of Slovenia
07After the Apocalypse: Inside The World's Most Breathtaking Ghost Towns
08Debate: Let's Stop Hating On Parents Who Want To Raise Adventurous Kids
09Guns, Roses, And Eating Insects: Adventure Cycling in Vietnam
10From Intense Trails to Intensive Care: Dicing with Death In a Mountain Biking Paradise
Bendcrete Skateparks - Humberside
A Skateboarding video by grillalives - 3,286 views
Footage of Bendcrete parks in North Ferriby & Beverley, with a small cameo from Hyde park in Leeds
Video features - Alan Ibs, Danny Robinson, Ozzy, Ferg, Fordy, Jack, Louis, Matty Hall, Mike Foreman, Mirza Ibs, Nobby, Scott Palmer, Phil Oaks, Rob Jackson, Royce Honeyset, Sala & Paul Regan
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It was just another day in Shawn Marion's trade rumor-driven world. That is, until he attended the team Christmas party at Pat Riley's house, where the latest trade rumor was televised on the news scroll of a popular, widely viewed entertainment and sports programming network.
Though a person with direct knowledge of the situation said Miami and Cleveland haven't held any trade discussions in months, reports of a possible deal sending Marion to Cleveland for Wally Szczerbiak and Anderson Varejao were nonetheless the talk of the party at Riley's house Tuesday night.
"What am I going to do? I'm going to sit there and panic every time somebody says something?" said Marion, whose $17.8 million expiring contract -- and 12.4-point scoring average -- will have him front-and-center of trade talk between now and the Feb. 19 deadline.


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Are you Yadi Wu?Claim your profile
Publications (22)198.36 Total impact
Article: PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21.[Show abstract] [Hide abstract]
ABSTRACT: Protein phosphatase 2A (PP2A) plays an important role in the control of the cell cycle. We previously reported that the PP2A inhibitors, cantharidin and okadaic acid (OA), efficiently repressed the growth of cancer cells. In the present study, we found that PP2A inhibitors arrested the cell cycle at the G2 phase through a mechanism that was dependent on the JNK pathway. Microarrays further showed that PP2A inhibitors induced expression changes in multiple genes that participate in cell cycle transition. To verify whether these expression changes were executed in a PP2A-dependent manner, we targeted the PP2A catalytic subunit (PP2Ac) using siRNA and evaluated gene expression with a microarray. After the cross comparison of these microarray data, we identified that CDK1 was potentially the same target when treated with either PP2A inhibitors or PP2Ac siRNA. In addition, we found that the down-regulation of CDK1 occurred in a JNK-dependent manner. Luciferase reporter gene assays demonstrated that repression of the transcription of CDK1 was executed through the JNK-dependent activation of the Sp1 transcription factor. By constructing deletion mutants of the CDK1 promoter and by using ChIP assays, we identified an element in the CDK1 promoter that responded to the JNK/Sp1 pathway after stimulation with PP2A inhibitors. Cantharidin and OA also up-regulated the expression of p21, an inhibitor of CDK1, via autophagy rather than PP2A/JNK pathway. Thus, this present study found that the PP2A/JNK/Sp1/CDK1 pathway and the autophagy/p21 pathway participated in G2/M cell cycle arrest triggered by PP2A inhibitors.Oncotarget 05/2015; · 6.63 Impact Factor
Article: Gprc5a -deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway[Show abstract] [Hide abstract]
ABSTRACT: Susceptibility to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) varies greatly among patients in sepsis/septic shock. The genetic and biochemical reasons for the difference are not fully understood. G protein coupled receptor family C group 5 member A (GPRC5A), a retinoic acid target gene, is predominately expressed in the bronchioalveolar epithelium of lung. We hypothesized that Gprc5a is important in controlling the susceptibility to ALI or ARDS. In this study, we examined the susceptibility of wild-type and Gprc5a-knockout (ko) mice to induced ALI. Administration of endotoxin LPS induced anincreased pulmonary edema and injury in Gprc5a-ko mice, compared to wild-type counterparts. Consistently, LPS administration induced higher levels of inflammatory cytokines (IL-1β and TNFα) and chemokine (KC) in Gprc5a-ko mouse lungs than in wild-type. The enhanced pulmonary inflammatory responses were associated with dysregulated NF-κB signaling in the bronchioalveolar epithelium of Gprc5a-ko mouse lungs. Importantly, selective inhibition of NF-κB through expression of the super-repressor IκBα in the bronchioalveolar epithelium of Gprc5a-ko mouse lungs alleviated the LPS-induced pulmonary injury, and inflammatory response. Thus, Gprc5a is critical for lung homeostasis, and Gprc5a deficiency confers the susceptibility to endotoxin-induced pulmonary edema and injury, mainly through NF-κB signaling in bronchioalveolar epithelium of lung.Cell cycle (Georgetown, Tex.) 02/2015; 14(9). DOI:10.1080/15384101.2015.1006006 · 5.01 Impact Factor
Article: G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma.Oncotarget 01/2015; · 6.63 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.12/2014; 1(3):e963426. DOI:10.4161/21624011.2014.963426
- [Show abstract] [Hide abstract]
ABSTRACT: Tetraspanin CD151 interacts with laminin-binding integrins (i.e., α3β1, α6β1 and α6β4) and other cell surface molecules to control diverse cellular and physiological processes, ranging from cell adhesion, migration and survival to tissue architecture and homeostasis. Here, we report a novel role of CD151 in maintaining the branching morphogenesis and activity of progenitor cells during the pubertal development of mammary glands. In contrast to the disruption of laminin-binding integrins, CD151 removal in mice enhanced the tertiary branching in mammary glands by 2.4-fold and the number of terminal end buds (TEBs) by 30%, while having minimal influence on either primary or secondary ductal branching. Consistent with these morphological changes are the skewed distribution of basal/myoepithelial cells and a 3.2-fold increase in proliferating Ki67-positive cells. These novel observations suggest that CD151 impacts the branching morphogenesis of mammary glands by upregulating the activities of bipotent progenitor cells. Indeed, our subsequent analyses indicate that upon CD151 removal the proportion of CD24(Hi)CD49f(Low) progenitor cells in the mammary gland increased by 34%, and their proliferating and differentiating activities were significantly upregulated. Importantly, fibronectin, a pro-branching extracellular matrix (ECM) protein deposited underlying mammary epithelial or progenitor cells, increased by >7.2-fold. Moreover, there was a concomitant increase in the expression and nuclear distribution of Slug, a transcription factor implicated in the maintenance of mammary progenitor cell activities. Taken together, our studies demonstrate that integrin-associated CD151 represses mammary branching morphogenesis by controlling progenitor cell activities, ECM integrity and transcription program.Cell cycle (Georgetown, Tex.) 09/2014; 13(17):2707-2722. DOI:10.4161/15384101.2015.945823 · 5.01 Impact Factor
Article: Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer.[Show abstract] [Hide abstract]
ABSTRACT: Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene expression. Here we report a mechanism by which Twist recruits BRD4 to direct WNT5A expression in basal-like breast cancer (BLBC). Twist contains a "histone H4-mimic" GK-X-GK motif that is diacetylated by Tip60. The diacetylated Twist binds the second bromodomain of BRD4, whose first bromodomain interacts with acetylated H4, thereby constructing an activated Twist/BRD4/P-TEFb/RNA-Pol II complex at the WNT5A promoter and enhancer. Pharmacologic inhibition of the Twist-BRD4 association reduced WNT5A expression and suppressed invasion, cancer stem cell (CSC)-like properties, and tumorigenicity of BLBC cells. Our study indicates that the interaction with BRD4 is critical for the oncogenic function of Twist in BLBC.Cancer cell 02/2014; 25(2):210-25. DOI:10.1016/j.ccr.2014.01.028 · 23.89 Impact Factor
Article: The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-like Traits to Breast Cancer Cells.[Show abstract] [Hide abstract]
ABSTRACT: LSD1 is a critical chromatin modulator that controls cellular pluripotency and differentiation through the demethylation of H3K4me1/2. Overexpression of LSD1 has been observed in many types of tumors and is correlated with its oncogenic effects in tumorigenesis. However, the mechanism leading to LSD1 upregulation in tumors remains unclear. Using an unbiased siRNA screening against all the human deubiquitinases, we identified USP28 as a bona fide deubiquitinase of LSD1. USP28 interacted with and stabilized LSD1 via deubiquitination. USP28 overexpression correlated with LSD1 upregulation in multiple cancer cell lines and breast tumor samples. Knockdown of USP28 resulted in LSD1 destabilization, leading to the suppression of cancer stem cell (CSC)-like characteristics in vitro and inhibition of tumorigenicity in vivo, which can be rescued by ectopic LSD1 expression. Our study reveals a critical mechanism underlying the epigenetic regulation by USP28 and provides another treatment approach against breast cancer.Cell Reports 09/2013; DOI:10.1016/j.celrep.2013.08.030 · 7.21 Impact Factor
Article: Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer[Show abstract] [Hide abstract]
ABSTRACT: The epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers tumor cells with cancer stem cell (CSC)-like characteristics. We show that the Snail-G9a-Dnmt1 complex, which is critical for E-cadherin promoter silencing, is also required for the promoter methylation of fructose-1,6-biphosphatase (FBP1) in basal-like breast cancer (BLBC). Loss of FBP1 induces glycolysis and results in increased glucose uptake, macromolecule biosynthesis, formation of tetrameric PKM2, and maintenance of ATP production under hypoxia. Loss of FBP1 also inhibits oxygen consumption and reactive oxygen species production by suppressing mitochondrial complex I activity; this metabolic reprogramming results in an increased CSC-like property and tumorigenicity by enhancing the interaction of β-catenin with T-cell factor. Our study indicates that the loss of FBP1 is a critical oncogenic event in EMT and BLBC.Cancer cell 02/2013; 23(3). DOI:10.1016/j.ccr.2013.01.022 · 23.89 Impact Factor
- Tumor Microenvironment and Myelomonocytic Cells, 03/2012; , ISBN: 978-953-51-0439-1
Article: G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer[Show abstract] [Hide abstract]
ABSTRACT: Breast cancers are highly heterogeneous but can be grouped into subtypes based on several criteria, including level of expression of certain markers. Claudin-low breast cancer (CLBC) is associated with early metastasis and resistance to chemotherapy, while gene profiling indicates it is characterized by the expression of markers of epithelial-mesenchymal transition (EMT) - a phenotypic conversion linked with metastasis. Although the epigenetic program controlling the phenotypic and cellular plasticity of EMT remains unclear, one contributor may be methylation of the E-cadherin promoter, resulting in decreased E-cadherin expression, a hallmark of EMT. Indeed, reduced E-cadherin often occurs in CLBC and may contribute to the early metastasis and poor patient survival associated with this disease. Here, we have determined that methylation of histone H3 on lysine 9 (H3K9me2) is critical for promoter DNA methylation of E-cadherin in three TGF-β-induced EMT model cell lines, as well as in CLBC cell lines. Further, Snail interacted with G9a, a major euchromatin methyltransferase responsible for H3K9me2, and recruited G9a and DNA methyltransferases to the E-cadherin promoter for DNA methylation. Knockdown of G9a restored E-cadherin expression by suppressing H3K9me2 and blocking DNA methylation. This resulted in inhibition of cell migration and invasion in vitro and suppression of tumor growth and lung colonization in in vivo models of CLBC metastasis. Our study not only reveals a critical mechanism underlying the epigenetic regulation of EMT but also paves a way for the development of new treatment strategies for CLBC.The Journal of clinical investigation 03/2012; 122(4):1469-86. DOI:10.1172/JCI57349 · 13.77 Impact Factor
Article: Snail: More than EMT[Show abstract] [Hide abstract]
ABSTRACT: Snail has moved into the fast lane of development and cancer biology with the epithelial-mesenchymal transition (EMT) emerging as one of the hottest topics in medical science within the past few years. Snail not only acts primarily as a key inducer of EMT but also plays an important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of Snail and discusses the EMT-dependent and -independent functions of Snail in development and disease. Understanding the regulation and functional roles of Snail will shed new light on the mechanism of tumor progression and the development of novel cancer therapies.Cell adhesion & migration 04/2010; 4(2):199-203. DOI:10.4161/cam.4.2.10943 · 3.40 Impact Factor
Article: The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1[Show abstract] [Hide abstract]
ABSTRACT: Epithelial-mesenchymal transition (EMT) is a transdifferentiation programme. The mechanism underlying the epigenetic regulation of EMT remains unclear. In this study, we identified that Snail1 interacted with histone lysine-specific demethylase 1 (LSD1). We demonstrated that the SNAG domain of Snail1 and the amine oxidase domain of LSD1 were required for their mutual interaction. Interestingly, the sequence of the SNAG domain is similar to that of the histone H3 tail, and the interaction of Snail1 with LSD1 can be blocked by LSD1 enzymatic inhibitors and a histone H3 peptide. We found that the formation of a Snail1-LSD1-CoREST ternary complex was critical for the stability and function of these proteins. The co-expression of these molecules was found in cancer cell lines and breast tumour specimens. Furthermore, we showed that the SNAG domain of Snail1 was critical for recruiting LSD1 to its target gene promoters and resulted in suppression of cell migration and invasion. Our study suggests that the SNAG domain of Snail1 resembles a histone H3-like structure and functions as a molecular hook for recruiting LSD1 to repress gene expression in metastasis.The EMBO Journal 04/2010; 29(11):1803-16. DOI:10.1038/emboj.2010.63 · 10.75 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Epithelial–mesenchymal transition (EMT) is critical for appropriate embryo implantation, embryogenesis, wound healing, tissue regeneration, and organ development. During this EMT process, epithelial cells lose the adherent and tight junctions. They gain a mesenchymal cell phenotype that enables them to invade and migrate over long distances and resist apoptosis. A similar process is also detected in tumor metastasis, suggesting that the tumor cells hijack this developmental pathway for tumor progression. Here, we review three different types of EMT in physiological and pathological conditions with special focus on the new development on type 3 EMT in metastasis. We summarize the recent new findings on tumor microenvironment, signaling pathways, and mechanisms underlying the regulation of EMT at metastasis. Understanding the biology of EMT will open new avenues for controlling fibrosis and cancer progression.12/2009: pages 187-211;
- [Show abstract] [Hide abstract]
ABSTRACT: It has been increasingly recognized that tumor microenvironment plays an important role in carcinogenesis. Inflammatory component is present and contributes to tumor proliferation, angiogenesis, metastasis and resistance to hormonal and chemotherapy. This review highlights the role of inflammation in the tumor metastasis. We focus on the function of proinflammatory factors, particularly cytokines during tumor metastasis. Understanding of the mechanisms by which inflammation contributes to metastasis will lead to innovative approach for treating cancer. How tumor spread remains an enigma and has received great attention in recent years, as metastasis is the major cause of cancer mortality. The complex and highly selective metastatic cascade not only depends on the intrinsic properties of tumor cells but also the microenvironment that they derive from. An inflammatory milieu consisting of infiltrated immune cells and their secretory cytokines, chemokines and growth factors contribute significantly to the invasive and metastatic traits of cancer cells. Here, we review new insights into the molecular pathways that link inflammation in the tumor microenvironment to metastasis.Cell cycle (Georgetown, Tex.) 10/2009; 8(20):3267-73. DOI:10.4161/cc.8.20.9699 · 5.01 Impact Factor
Article: Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion[Show abstract] [Hide abstract]
ABSTRACT: The increased motility and invasiveness of tumor cells are reminiscent of epithelial-mesenchymal transition (EMT), which occurs during embryonic development, wound healing, and metastasis. In this study, we found that Snail is stabilized by the inflammatory cytokine TNFalpha through the activation of the NF-kappaB pathway. We demonstrated that NF-kappaB is required for the induction of COP9 signalosome 2 (CSN2), which, in turn, blocks the ubiquitination and degradation of Snail. Furthermore, we showed that the expression of Snail correlated with the activation of NF-kappaB in cancer cell lines and metastatic tumor samples. Knockdown of Snail expression inhibited cell migration and invasion induced by inflammatory cytokines and suppressed inflammation-mediated breast cancer metastasis. Our study provides a plausible mechanism for inflammation-induced metastasis.Cancer cell 06/2009; 15(5):416-28. DOI:10.1016/j.ccr.2009.03.016 · 23.89 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Snail, a key inducer of epithelial-mesenchymal transition (EMT), plays an important role in cancer metastasis. To better understand the role of Snail in the metastasis of ovarian carcinoma, expression of Snail was knocked down by antisense-Snail in the highly metastatic ovarian cancer cell line HO8910PM. Gene array analysis revealed that blocking Snail expression suppressed the activity of matrix metalloproteinases (MMPs) and upregulated TIMP3, an MMP inhibitor. These findings suggest that Snail interacts with MMP during tumor invasion and metastasis. In addition, we examined the role of Snail in an ovarian cancer orthotopic model by using the antisense-Snail HO8910PM cell line. We found that the size of primary ovarian cancer tumor and the number of metastatic lesions were significantly reduced when Snail was knocked down. Confirming our initial findings, the activity of MMP2 was greatly inhibited in tumors from antisense-Snail cells. Furthermore, immunohistochemical analysis on ovarian cancer progression tissue array demonstrated that the expression of Snail was significantly higher in metastatic lesions, and Snail expression correlated with the stage of ovarian cancer. Interestingly, in early-stage tumors, Snail was localized in both the cytoplasm and nucleus. In late stage and metastatic lesions, the level of Snail was elevated, and Snail was localized to the nucleus. The expression level and nuclear localization of Snail were also inversely correlated with E-cadherin expression. Overall, our study indicates that Snail plays a critical role in tumor growth and metastasis of ovarian carcinoma through regulation of MMP activity.International Journal of Cancer 01/2009; 126(9):2102-11. DOI:10.1002/ijc.24901 · 5.01 Impact Factor
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ABSTRACT: Down-regulation of E-cadherin plays an important role in epithelial-mesenchymal transition (EMT), which is critical in normal development and disease states such as tissue fibrosis and metastasis. Snail, a key transcription repressor of E-cadherin, is a labile protein with a short half-life and is regulated through phosphorylation, ubiquitination, and degradation. Previously, we showed that GSK-3beta phosphorylated two stretches of serine residues within the nuclear export signal and the destruction box of Snail, provoking its cytoplasmic export for ubiquitin-mediated proteasome degradation. However, the mechanism of Snail dephosphorylation and the identity of the Snail-specific phosphatase remain elusive. Using a functional genomic screening, we found that the small C-terminal domain phosphatase (SCP) is a specific phosphatase for Snail. SCP interacted and co-localized with Snail in the nucleus. We also found that SCP expression induced Snail dephosphorylation and stabilization in vitro and in vivo. However, a catalytically inactive mutant of SCP had no effect on Snail. Furthermore, we found that Snail stabilization induced by SCP enhanced snail activity in the suppression of E-cadherin and increased cell migration. Thus, our findings indicate that SCP functions as a Snail phosphatase to control its phosphorylation and stabilization, and our study provides novel insights for the regulation of Snail during EMT and cancer metastasis.Journal of Biological Chemistry 12/2008; 284(1):640-8. DOI:10.1074/jbc.M806916200 · 4.60 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Epithelial-mesenchymal transition (EMT) is a key step during embryonic morphogenesis, heart development, chronic degenerative fibrosis, and cancer metastasis. Several distinct traits have been conveyed by EMT, including cell motility, invasiveness, resistance to apoptosis, and some properties of stem cells. Many signal pathways have contributed to the induction of EMT, such as transforming growth factor-beta, Wnt, Hedgehog, Notch, and nuclear factor-kappaB. Over the last few years, increasing evidence has shown that EMT plays an essential role in tumor progression and metastasis. Understanding the molecular mechanism of EMT has a great effect in unraveling the metastatic cascade and may lead to novel interventions for metastatic disease.Acta Biochimica et Biophysica Sinica 08/2008; 40(7):643-50. DOI:10.1111/j.1745-7270.2008.00443.x · 2.09 Impact Factor
Article: Kinases meet at TSC.Cell Research 01/2008; 17(12):971-3. DOI:10.1038/cr.2007.106 · 11.98 Impact Factor
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ABSTRACT: Many receptor tyrosine kinases (RTKs) can be detected in the cell nucleus, such as EGFR, HER-2, HER-3, HER-4, and fibroblast growth factor receptor. EGFR, HER-2 and HER-4 contain transactivational activity and function as transcription co-factors to activate gene promoters. High EGFR in tumor nuclei correlates with increased tumor proliferation and poor survival in cancer patients. However, the mechanism by which cell-surface EGFR translocates into the cell nucleus remains largely unknown. Here, we found that EGFR co-localizes and interacts with importins alpha1/beta1, carriers that are critical for macromolecules nuclear import. EGFR variant mutated at the nuclear localization signal (NLS) is defective in associating with importins and in entering the nuclei indicating that EGFR's NLS is critical for EGFR/importins interaction and EGFR nuclear import. Moreover, disruption of receptor internalization process using chemicals and forced expression of dominant-negative Dynamin II mutant suppressed nuclear entry of EGFR. Additional evidences suggest an involvement of endosomal sorting machinery in EGFR nuclear translocalization. Finally, we found that nuclear export of EGFR may involve CRM1 exportin as we detected EGFR/CRM1 interaction and markedly increased nuclear EGFR following exposure to leptomycin B, a CRM1 inhibitor. Collectively, these data suggest the importance of receptor endocytosis, endosomal sorting machinery, interaction with importins alpha1/beta1, and exportin CRM1 in EGFR nuclear-cytoplasmic trafficking. Together, our work sheds light into the nature and regulation of the nuclear EGFR pathway and provides a plausible mechanism by which cells shuttle cell-surface EGFR and potentially other RTKs through the nuclear pore complex and into the nuclear compartment.Journal of Cellular Biochemistry 08/2006; 98(6):1570-83. DOI:10.1002/jcb.20876 · 3.37 Impact Factor
Top Journals
University of Kentucky
Lexington, Kentucky, United States
- • Department of Molecular & Biomedical Pharmacology
- • Department of Molecular & Cellular Biochemistry
University of Texas Medical Branch at Galveston
Galveston, Texas, United States
- • Department of Pharmacology and Toxicology
- • Sealy Center for Cancer Cell Biology
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
- Department of Molecular and Cellular Oncology


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Ron: Positive thinking is the key to success in business, education, pro football, anything that you can mention. I go out there thinking that I'm going to complete every pass.
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Crazy Cat Lady Grande Mug
Roll over image to zoom in
What's so crazy about being a cat lady? You love felines -- and best of all, they love you. Our mug features a charming collection of heart-shaped paw prints along with the words Crazy Cat Lady...and proud of it!
- Dolomite ceramic
- Dishwasher safe
- 16 oz capacity
- 4.75" H x 3.75" dia. at top (12 x 9.2 cm)
- Imported
For bulk pricing on these and other items, please contact our Customer Service department at email@example.com.
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July 1, 2015 - Very cute and good workmanship. Very big mug. Would write more, but I bought it for a gift, so I have nothing more to say about it.
June 18, 2015 - I just love this mug! Great quality and awesome size. You have to make one in pink please!
June 7, 2015 - I love this mug! I only have four kitties right now, but my younger son has referred to me as the "crazy cat lady" for years. The mug is very cute and just the right size for my first cup of coffee. And, it goes great with my "one cat short of being a crazy cat lady" t-shirt!
April 17, 2015 - I love this mug. Just the right size for my morning coffee. Big enough that I only have to fill it once to get my two cups in. Since I own 8 cats it is the perfect sentiment for me. I should correct that and say they own me!!! Most of my friends know me as the "cat lady" as do the people at the Shelter where I adopt my cats.
April 15, 2015 - Nice weight - unique color (marine blue), and the sentiment suites me!
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LACare - Lakes Area Care, Inc.
About Us
Contact Us
Get Involved
Website Designed
List Your Business for Free
Lakes Area Care, Inc. (LACare) is an ecumenical, nonprofit organization providing emergency food for families residing in the Burnet Consolidated Independent School District.
LACare offers nutrition classes and serves as a referral clearinghouse of other services and resources located in the community, including RX Advocates.
Our Mission: To feed the hungry! Because we care!
Thank you Friends of LACare!
We salute Nancy and David Richter for their generous donation to LACare. Thank you for helping us as we continue our mission to feed the hungry.
Hats Off to Burnet's Epsilon Pi Sorority! LACare was one of the recipients of many donations to local non-profit organizations.
Save the Date
Saturday July 4
Celebrate the birthday of American with friends, family and loved ones!
2015 Annual National Food Drive - "Stamp Out Hunger"
Sponsored by the National Association of Letter Carriers
Burnet area residents donated a walloping 7300 pounds of food during the Saturday May 9 17th Annual National Food Drive. "Stamp Our Hunger" is the nations largest food drive and is sponsored by the National Association of Letter Carriers. Thank you to all who donated and a huge thanks for the area letter carriers!
LACare Celebrates 30 Years Feeding the Hungry in Burnet CISD
Thank you to all that attended!
Mayor Wideman and Chairman, LACare Board of Directors Marjorie Bronk
Left, Dixie Bridges and the amazing presentation of historical information compiled by Carole Goble, right.


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Sweet Potato Casserole With Praline Topping
Total Time
Prep 15 mins
Cook 30 mins
A wonderful holiday dish. Definitely a crowd pleaser!
Make and share this Sweet Potato Casserole With Praline Topping recipe from Food.com.
Ingredients Nutrition
- FILLING: Mash potatoes in a medium sized bowl. Add all the other filling ingredients; mix well. Pour into a greased deep dish pie pan or 8x8 deep casserole dish.
- TOPPING: Mix all ingredients well and sprinkle over top of potato mixture.
- Bake at 350°F for 30 minutes.
Most Helpful
I made the recipe just as posted, except I also added some fresh ground nutmeg. Nothing but raves for this. Just the right amount of praline/potato ratio :) Fantastic dish! Thank you for posting
This was a wonderful recipe. I made it from leftover holiday sweet potatoes. I made one for me and one for a sick friend and gave it to her while still warm. When I got home she called me and said she was instantly healed from it, it was so good and such good comfort food.
thank you
Yet another wonderful version of this recipe that we have during this season. Made recipe as posted and will become a holiday favorite. Made for PRMR tag.


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