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Works to advance the frontiers of the behavioral and social sciences and their applications to public policy. Read more
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Conducts a range of activities where policy meets the life sciences, including the environment, geography, laboratory animal use, and natural resource issues. Read more
Focuses on government missions in defense, space, and aerospace; national infrastructure challenges; science and engineering disciplines; and continuing assessments of federal labs and research programs. Read more
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The analysis used to set standards for fuel economy and greenhouse gas emissions for new U.S. passenger cars and light trucks from 2017 to 2025 was of high caliber overall, but NHTSA and EPA should re-examine certain issues, says a new National Research Council report.
Wait times for health care appointments vary tremendously throughout the U.S., ranging from same day service to several months, says a new report from the Institute of Medicine.
A new report from the National Research Council offers alternative approaches for calculating risk-based flood insurance that capture the unique conditions affecting flood risk for low-lying structures.
Cardiac arrest strikes almost 600,000 people each year, killing the vast majority of those individuals, says a new report from the Institute of Medicine.
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Our mission is to improve government decision making and public policy, increase public understanding, and promote the acquisition and dissemination of knowledge in matters involving science, engineering, technology, and health. Our independent, expert reports and other scientific activities inform policies and actions that have the power to improve the lives of people in the U.S. and around the world. Seven major programs of the National Academies of Sciences, Engineering, and Medicine conduct studies, facilitate workshops, and undertake other activities: Behavioral and Social Sciences and Education; Earth and Life Studies; Engineering and Physical Sciences; Institute of Medicine; Policy and Global Affairs; Transportation Research Board; and the Gulf Research Program.
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Survival rate in cardiac arrest is far too low, more CPR training needed, panel says - Washington Post, June 30, 2015
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For Automakers, Fuel Economy Targets May Be Less of a Stretch - New York Times, June 18, 2015
U.S. researchers see auto fuel standards driving technology - Reuters, June 18, 2015
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Release of encyclical reveals pope's deep dive into climate science - Washington Post, June 18, 2015
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National Academies releases U.S. freight rail regulations report - American Shipper, June 10, 2015
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sf/f TV development news - 2013
View Single Post
February 26 2014, 03:58 AM
Out Of My Vulcan Mind
Vice Admiral
Location: Wherever you go, there you are.
Re: sf/f TV development news - 2013
Those are shows that have aired this season or that will air in the rest of the season and through the summer. It doesn't include pilots or anything in development for the 2014/2015 season. Actually it's 46. I had missed three in my earlier count.
Here's the list in order of the season airing in the 2013/2014 season and summer 2014 (again these are just the live action one-hour shows produced for North American outlets - if you include UK shows and half-hour shows the number is even greater):
9th season
Supernatural (CW)
7th season
True Blood (HBO, final season)
5th season
The Listener (CTV, air date TBA)
The Vampire Diaries (CW)
Warehouse 13 (Syfy, final season)
4th season
Being Human (Syfy, final season)
Falling Skies (TNT)
Game of Thrones ( HBO)
Haven (Syfy)
Lost Girl (Syfy/Showcase)
The Walking Dead (AMC)
3rd season
American Horror Story (FX)
Continuum (Syfy/Showcase)
Grimm (NBC)
Once Upon a Time (ABC)
Person of Interest (CBS)
Teen Wolf (MTV, season 4 likely starts this summer)
2nd season
Arrow (CW)
Beauty and the Beast (CW)
Da Vinci's Demons (Starz)
Defiance (Syfy)
Hemlock Grove (Netflix, release date TBA)
Orphan Black (BBC America)
Revolution (NBC)
Under the Dome (CBS)
1st season
The 100 (CW)
Agents of SHIELD (ABC)
Almost Human (Fox)
Believe (NBC)
Bitten (Syfy/Space)
Dracula (NBC)
From Dusk till Dawn: The Series (El Rey)
Helix (Syfy)
Intelligence (CBS)
The Last Ship (TNT)
Once Upon a Time in Wonderland (ABC)
The Originals (CW)
Penny Dreadful (Showtime)
Ravenswood (ABC Family, cancelled)
Resurrection (ABC)
Salem (WGN)
Sleepy Hollow (Fox)
Star-Crossed (CW)
The Strain (FX)
The Tomorrow People (CW)
Witches of East End (Lifetime)
"I'll see you in another life, brother."
Last edited by Out Of My Vulcan Mind; February 26 2014 at
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subset: commoncrawl


text:
I have various very large JavaScript files, and need to extract only certain strings. The input would be hundreds of lines like this:
function foo("ignore this string"){
var n = "copy this";
function bar("copy this string"){
var i = "ignore this string";
var globalX ="copy if over a certain length";
var globalY ="copy if within 2 lines of 'globalX'";
The output would be a simple list of strings. Writing the rules would not be hard, but can JavaScript read 100 pages of code and treat it like a string for parsing purposes? if not, what other tools should I use? Any suggestions are welcome!


text:
List your latest posts by category using simple shortcode.
Use the following shortcode anywhere on your page or post following the examples below: [utech_latest_posts category='news'] replace the word news in this example with the category that you would like to use.
[utech_latest_posts category='news' limit=10]
this example limits the number of results to 10 instead of the default which is 5 entries


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#OOTD |Ankara Peplum and High Waist Pencil Skirt | Sunday Service @ Glad Tidings
For last Sunday's service, I went on another print mixing scheme! Paired my Freakum Dress Couture Sankofa Ankara Peplum (worn once before here) with a black and white striped high waist pencil skirt. I added on a red purse and a black pointy toe shoe. What are your thoughts? Connect with me :) Instagram / Facebook Page / Lookbook / Bloglovin' / Youtube / Pinterest / LinkedIn


text:
Sorry, this item is currently
HN-MPM083 Molly P. Apparel
Molly P. Apparel Laura 21 in. Doll EnsembleItem # HN-MPM083
Roll over to zoom
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- Great gift addition for Me and Molly P. 21-inch Baby Doll
- Deep purple corduroy dress with embroidered flowers
- Satin ribbon sits atop a ruffled hem
- White blouse trimmed in purple stitching
- Matching hair bows for your doll's hair
Full Description
Guarantee & Returns
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Molly P. Apparel
Molly P. Apparel Laura 21 in. Doll Ensemble
Unmistakably regal, the Molly P. Apparel Laura 21 in. Doll Ensemble Purple is perfect for taking your doll out on the town. This deep purple corduroy dress is embroidered with a bouquet of purple and lavender flowers and has a lovely purple satin ribbon atop a ruffled hem. The white blouse is outlined with purple stitching which perfectly coordinates with the dress. Dress up your doll's hair with the purple hair bows and keep her warm with the matching blanket which adds to her dressy look. Ad


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Masterpiece 1971 | TV Show Watchlist
Season 30, Episode 9 Bramwell VI
First Aired: January 28, 2001
"Bramwell": Robert and Mrs. Costigan (David Calder, Maureen Beattie) prepare to wed. That augers change for Eleanor (Jemma Redgrave) as well, thanks to Robert, who vows to cut her off if she remains at the Thrift because he fears for her safety. One reason for his fear: she's attacked at a prenuptial party there by the recently hired porter (Berwick Kaler), a friend of the mortified Nurse Carr (Ruth Sheen), who can't hold his liquor.
Guest Cast
Jemma Redgrave Jemma Redgrave Eleanor Bramwell
David Calder David Calder Robert Bramwell
Joane Hall Joane Hall Lily
Ben Brazier Ben Brazier Sidney Bentley
Kevin McMonagle Kevin McMonagle Joe Marsham
James Bree James Bree Vicar
Barbara Keogh Barbara Keogh Landlady
Tom Chadbon Tom Chadbon Bill North
Maureen Beattie Maureen Beattie Mrs. Costigan
Ruth Sheen Ruth Sheen Nurse Carr
Berwick Kaler Berwick Kaler Stan Collard
Next On TVSee all »
Thu Jul 2 9:00pm
Endeavour, Season 2: SwaySeason 44, Episode 16 PBS
Cast & Details See all »
- Premiered: January 10, 1971
- Rating: TV-PG
- User Rating:
- Premise: PBS's longest running (and most honored) dramatic series is an Anglophile's delight, featuring British adaptations of literary classics and original works. The first `Masterpiece' was `The First Churchills,' and since then it has won nine Peabodys and 29 E… (more)
Trending TonightSee all »
Under the Dome10:00 pm | CBSI'll Watch689 Watching
Wayward Pines9:00 pm | FOXI'll Watch676 Watching
Beauty and the Beast8:00 pm | CWI'll Watch509 Watching
Popular Shows
- 1. Game of Thrones
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- 7. Game of Thrones: A Day in the Life


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Space Rhumba
- Artists Xinobi, Mercury, Justin Faust
- Release Date 2013-09-30
- Labels Discotexas
- Catalog DT037
- Description Fuelled by a love of doing-it-yourself and set apart by their Latin flair, Discotexas is a crew of likeminded artists, an occasional club night around Europe and a record label now onto its 37th release. Helming it is Justin Faust, someone very much at the forefront of the nu-disco scene. Here he goes all out disco-party with his original, whilst label boss Xinobi and Mercury tackle the remixes.


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As a Personal Financial Representative in Rochester NY, I know many local families. My knowledge and understanding of the people in this community help me provide customers with an outstanding level of service. I look forward to helping families like yours protect the things that are important – your family, home, car and more. I can also help you prepare a strategy to achieve your financial goals.
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I'm committed to helping you protect what you have today and prepare for tomorrow. I understand the importance of thinking about the "big picture" when it comes to your financial future. From life insurance to retirement, I'm committed to helping you reach your financial goals.
When it comes to life insurance, Allstate agent Jay Haidari in Rochester wants to make the process as easy and hassle-free as possible by taking your individual needs into account. If you're considering coverage throughout different phases of your life, then perhaps a term life insurance policy is right for you. Allstate has helpful online resources that can help you learn about policy features. Or, call (585)225-2700 for more details!
Jay Haidari
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Rochester, NY, 14612
Send Me An Email


text:
Denim Art Can
We are adding the craft to your Craft Projects.
The project was added to your Craft Projects.
Click here to view your Craft Projects.
This Denim Art Can from Amanda Formaro is a great way to upcycle lots of things around your house. You can use it to store art supplies, pens and pencils, or even makeup! The possibilities are endless with this simple and creative upcycling project.
- Large recycled can
- Recycled denim blue jeans with seam
- Patterned fabric scraps
- Colored denim scraps*
- Scissors
- Hot glue gun
*Note: Color denim with clothing dye or paint with fabric paint.
Cut enough denim to go around the can, positioning the seam at the top of the can. Hot glue the denim to the can and trim excess.
Cut the letters A R T from patterned fabrics. Hot glue the letters to colored denim. Trim around the letters so that each letter has a denim border.
Glue the letters to the denim covered can, overlapping each letter.
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Christopher Grissett Photographer
JECarterModel Female Fayetteville, Georgia, US My MM URL: http://www.modelmayhem.com/jecarter
Mayhem # 2254112
About MeI love to model and be around people. I love the outdoors, sports, and I LOVE music. Athletic, musical and nature shoots are appealing to me! My goal on ModelMayhem is to become a well rounded model, getting strong in different modeling categories. I would love for this help my modeling hobby and continue to make it grow. I can be contacted via phone or email...message me for more info!
Christopher Grissett Photographer
Jarad Bryan Model
Taichi Hatano Retoucher
Mike Stewart Jr Model
Julio Cesar Photography Photographer
Mr_Sable Filmmaker
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Reader's Poll
Stock Watch
AISHWARYACompany ID [BOM:532975] Last trade:Rs.3.79 Trade time:3:30PM GMT+5:30 Value change:▼0.17 (-4.29%)
AIRTELCompany ID [BOM:532454] Last trade:Rs.434.80 Trade time:3:50PM GMT+5:30 Value change:▲1.25 (0.29%)
DHANUSCompany ID [BOM:532903] Last trade:Rs.0.09 Trade time:3:30PM GMT+5:30 Value change:▲0.01 (12.50%)
FINCABLESCompany ID [BOM:500144] Last trade:Rs.260.10 Trade time:3:52PM GMT+5:30 Value change:▲2.10 (0.81%)
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ZTE to build a backbone network for CERNET
ZTE Corporation is going to build a backbone network and help expand phase three of the China Education and Research Network (CERNET).
CERNET is a national academic computer network managed by the Ministry of Education and built and operated by universities and colleges such as Tsinghua University. Currently, CERNET is now the world's largest national academic computer network, with more than 20,000,000 users.
As part of the project, ZTE will provide its 100G solution and ZXONE 8000 series OTN products to build the backbone bearer network for CERNET. The phase three expansion of CERNET network aims to expand the coverage and transmission capacity of the network and to improve its speed and security. The network will cover Beijing, Chongqing, Dalian, Guangzhou, Hangzhou, Shanghai, Shenyang, Shenzhen, Wuhan and Xi'an. The total transmission distance of the network will exceed 10,000 km.
Commenting on winning the project, Xu Ming, vice-president, ZTE Corporation, says, "We are thrilled to cooperate with CERNET to build the largest coherent 100G network in the world. This project will promote the stable development of education in China."
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How safe is that fitness tracker you are using?
You are not going to believe thisJuly 1, 2015 9:22
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Saudi's Mobily to reissue 2014, Q1 2015 results after regulator probe
Dubai Holding appoints new managing director, CEO
HSBC Bank Oman agrees to sell Pakistan business to Meezan Bank
European tour operators evacuate thousands from Tunisia after attack
French group to invest at least $150 mln in Saudi's Kingdom Holding
Gold ticks up from 2-week low as market eyes Greece
Car bomb aimed at UAE officials kills three Somali soldiers in Mogadishu
Abu Dhabi's Etisalat jumps 13.8 pct on looser ownership curbs
RSE, Qatar teaming up to buy stake in Formula One
Qatar building boom proves a challenge for foreign construction firms
From media moguls to high powered executives, Al Marri's network reads like an Emirati top ten list.
June 14, 2009 12:03 by Dana El Baltaji
Al Rustamani is CEO of TECOM Business Parks, part of Dubai Holding, and an umbrella organization that incorporates free zone clusters such as Dubai Media City and Dubai Internet City. Al Rustamani is also a member of the UAE National Media Council. Both she and Al Marri are board members of Dubai Media Incorporated (DMI).
1 Comment
Rather than produce the same old content you have taken this subject to a whole new level . Kudos for not following the standard writing crowd.
Mona Al Marri
June 14 2009
Bashing the Dubai-bashers
June 14 2009


text:
Requesting Items
Please be aware the Cultural Collections Reading Room will be closed for painting Monday July 6th to Friday July 10th, re-opening Monday July 13th 2015
Submit your request for Rare Books material online prior to visiting the Cultural Collections Reading Room.
Deliveries to the Reading Room occur at the following times:
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Requests for material can be made online prior to visiting the Reading Room. To request material, please use our online request form (below).
Please note: items with the location 'UniM Bund' or SpC/Store are held in off-site storage and require 3-4 working days notice for retrieval.
Your material will be available to view in the Cultural Collections Reading Room at the time you have requested, unless otherwise notified.
Please complete all fields and click on Submit when finished.


text:
Revlon PhotoReady Makeup [DISCONTINUED]
2058 reviews
54% would repurchase
Package Quality: 4.4
Price: $$
Package Quality: 4.4
Price: $$
INGREDIENTS(Active Ingredients : Titanium Dioxide 1.1%, Zinc Oxide 2.0%) Water, Cyclopentasiloxane, Dimethicone, Cyclohexasiloxane, Butylene Glycol, Boron Nitride, Cetyl PEG/PPG-10/1 Dimethicone, Phenyl Trimethicone, PEG/PPG-18/18 Dimethicone, Sodium Chloride, Nylon-12, HDI/Trimethylol Hexyllactone Crosspolymer, Calcium Aluminium Borosilicate, Alumina, Trimethylsiloxysilicate, Glycerin, Bis-PEG/PPG-14/14 Dimethicone, Isodecyl Neopentanoate, Dimethicone/Bis-Isobutyl PPG-20 Crosspolymer, Trisiloxane, Methicone, Triethoxycaprylylsilane, Tribehenin, Methyl Methacrylate Crosspolymer, Cycloheptasiloxane, Silica, Sorbitan Sesquioleate, Tetrasodium EDTA, Phenoxyethanol, Caprylyl Glycol, 1,2-Hexanediol /- (CI 77019/Mica, CI 77891/Titanium Dioxide, CI 77491/CI 77492/CI 77499/Iron Oxides, CI 77947/Zinc Oxide)
on 7/31/2014 8:09:00 AM
Age: 25-29
Skin: Combination, Medium, Warm
Hair: Black, Wavy, Coarse
Eyes: Black
Love love loooooove this foundation. I will definitely repurchase it. No complaint at all. But if you prefer a matte finish, I don't recommend it tho. However, if u like a dewy finish like me, you will fall in love with this babe. The sparkling thingy doesn't bother me, I even like it. So, love!
on 7/28/2014 7:05:00 PM
Age: 25-29
Skin: Normal, Fair, Cool
Hair: Brown, Other, Fine
Eyes: Green
I tend to stay away from liquid foundations because I don't like to feel like I'm painting my skin. But every once and a while, a review convinces me to give liquid another try--that's how I ended up with PhotoReady. I really dislike this foundation. I find the colour to be a bit too yellow and the formula is too thin--I feel like it just sits on top of my skin and looks very obviously like makeup. Other reviewers have mentioned the shimmer and I strongly dislike that, as well. I'm 28 and I try to avoid putting any kind of glittery products on my face--it's most noticeable on your fingers after application and it's VERY difficult to wash off your hands. Overall, it just feels yucky. I have normal skin (not oily or dry), but I find that this foundation accentuates the tiniest bit of dryness in my skin and even after setting with powder, I get quite shiny during the day.
This product's only redeeming quality is its beautiful packaging and dispenser.
on 7/28/2014 3:08:00 PM
Age: 19-24
Skin: Combination, Fair, Neutral
Hair: Brown, Wavy, Coarse
Eyes: Other
Liquid foundations are the bane of my existence. I was in need of new foundation and decided to pick this up, as Revlon has a good deal of products that work for pale olive skin. While it matched my skin tone as well as I had expected, everything else about this product sucked. If you have dry skin, this foundation isn't for you. It clung to every dry patch, bump, and pore I had, even with lots of moisturizer and primer underneath. The coverage is very light and it takes a lot of product -- two pumps -- to build it up to medium. And as other reviewers have said, there's little sparkly bits in it. You can mostly avoid that by shaking the foundation before you apply it, but the sparkles will still be there. Not a flattering look, especially when it's cracked and spiderwebbing across your dry skin. Save your money, don't buy this.
on 7/7/2014 12:02:00 PM
Age: 25-29
Skin: Combination, Fair-Medium, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
I actually love the airbrushed and regular liquid of this product. It doesn't have a full coverage and it does sparkle but I love it. I already owned every product of this line and love it.
on 7/1/2014 8:16:00 AM
Age: 18 & Under
Skin: Combination, Fair, Not Sure
Hair: Brown, Other, Other
Eyes: Blue
I bought this product a couple of weeks ago and I have to say it's not very good. The texture is very watery and it's a struggle to get full coverage. It does however have a pleasant smell. The name stood out to me 'photo ready', I thought this would be a good foundation which his imperfections and stayed put but unfortunately this wasn't the story. I do have to add, if mixed with another foundation (I mixed with Collection 2000 Lasting Perfection) it does look superb and adds a slight shimmer to your face which brightens it up a little.
on 6/30/2014 4:45:00 PM
Age: 25-29
Skin: Combination, Fair, Not Sure
Hair: Brunette, Other, Other
Eyes: Blue
I feel really sad that so many people seem to have had a bad experience with this product :-(
I don't use this foundation every single day, but I use it enough. It's good quality drugstore foundation. I've never experienced growing pores or sparkling, but I also use a primer and finishing powder. Maybe I will try the foundation alone once to see if that happens.
It lasts for several hours (I sometimes work 12 hour shifts), without much fading at all and minimal to no touchups. My skintone is matched almost flawlessly.
on 6/30/2014 11:54:00 AM
Age: 19-24
Skin: Acne-prone, Fair-Medium, Neutral
Hair: Brown, Straight, Coarse
Eyes: Brown
Talk about cakey AND sparkles. I THOUGHT that I liked this at first, it does indeed look good in pictures, but gosh darn it feels like frosting on my face. Not to mention it broke me out too. Not a great choice for those with oily skin, as the sparkle reaches a turning point of looking good in photos, but then you are a shiny mess. The pump is really nice though.
on 6/28/2014 12:28:00 AM
Age: 25-29
Skin: Combination, Fair, Not Sure
Hair: Blond, Other, Other
Eyes: Hazel
This stuff made my pores look bigger
on 6/27/2014 9:15:00 PM
Age: 25-29
Skin: Combination, Medium, Neutral
Hair: Black, Straight, Fine
Eyes: Brown
Okay this is going to be a long review but a well thought out report of this foundation. I have a love/hate relationship with this foundation. When I first purchased it in Medium Beige 004 I thought holy crap thats a looot of sparkle, and yes it is definitely noticeable. Now, here is why there are such conflicting reports on the sparkle issue: the sparkles are white/silver and in the lighter shades they blend with the pigment really well, being almost unnoticeble on fair-light skintones, however, once the colours get darker the sparkles contrast with the foundation's pigment and become more noticable on medium-dark skintones. I'm guessing the ladies reporting no issues with sparkles are lighter skinned and thus do not have the same obvious sparkles on their face as the darker skinned ladies. I myself am wheatish and can see the sparkle, especial on hot days, and for anyone who is going to be in close proximity to another person (think professional settings/relationships) its just plain embarassing to have your makeup look so obvious. However whenever I have been photographed with this foundation on, my skin looks so uniform and smooth and not sparkly at all, it really does create a photoready effect. Also, its lasts a looong time on my combo skin, I just need to blot once during the day. I don't like that the sparkles make the oil on my forehead stand out, or that its so sparkly but I love the medium to full coverage and the smoothing effect it has on skin. So, for something that has to be worn on a not-so-sunny day in a not-so-initmate or close up setting I definitely reach for this the most. It has never broken me out and the packaging is very nice and convenient. Try it, it will work for night events for sure. I've found the best way to use it is to shake it really well to distribute sparkles evenly and then apply in thin layers with downward strokes using your fingers, not a brush.
on 6/26/2014 10:28:00 AM
Age: 19-24
Skin: Acne-prone, Fair-Medium, Not Sure
Hair: Black, Other, Other
Eyes: Green
I was really wanting to love this. Way too sparkly, you look like a twilight vampire when you step outside... And if you have acne it totally draw attention to it. I find the foundation doesn't go on smoothly... I've tried a foundation brush, beauty blender, stipple brush, hands... No success. I purchased this at Walmart US for $10.97 and it will probably remain sitting in my cupboard. I think this product would be great for girls with clear skin looking for a boost, but us girls with acne and scarring this is NOT for you!
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text:
Articles on The Daily Caller by keyword: Justin Bieber
Martha Stewart On The Justin Bieber Roast: 'I Was Totally High'
Entertainment |
She did sit next to Snoop Dogg
BREAKING: Justin Bieber's Golf Game, Even Worse Than His Arm Tats
Entertainment |
F*****g terrible, Biebs
Who Let Justin Bieber Adopt Another Animal So He Can Just Ignore It?
Entertainment |
Just great
Justin Bieber's Neighbor Is Suing Him Because His Bodyguard Called Him A Name
Entertainment |
'Suffered emotional distress'
Kevin Hart: I'm Pretty Sure Justin Bieber Cried In The Car After His Roast
Entertainment |
'So this is like his bar mitzvah?'
Chrissy Teigen Won The Red Carpet With Not One, But Two Thigh-High Slits
Entertainment |
That thing barely counts as a dress
Kevin Hart On Justin Bieber: 'We're Going To Give This Boy The A** Whooping He Deserves'
Entertainment |
'Gonna do what Justin's parents and the legal system should have'
Former Inmate To Roast Justin Bieber On Comedy Central
Entertainment |
That's right
Why Is This Gorgeous Model Dating Justin Bieber?
Entertainment |
No, seriously. Why?
Justin Bieber Apologizes For Being World's Biggest Douchebag
Entertainment |
It's about time
Beliebers Secure All-Star Starter Status For Toronto Point Guard
Sports |
Don't mess with the Biebs
Justin Bieber Just Got The Worst Haircut Of His LIFE
Entertainment |
And how does it get worse than dying it platinum blonde?
'SNL' Mocks Justin Bieber's Junk In HILARIOUS Skit
Entertainment |
And his response will surprise you
Is Selena Gomez Purposely Tormenting Justin Bieber With Her Outrageous Cleavage?
Entertainment |
Gay Republicans Mistake Crasher Justin Bieber For 'Butcher Version Of Miley Cyrus'
Entertainment |
'I just saw a bunch of girls'
PROOF: Justin Bieber Is The Immature Child We Thought He Was
Entertainment |
This is just plain embarrassing
Topless Model Gets Death Threats For Touching Justin Bieber
Entertainment |
Should have kept your shirt on, girl
Justin Bieber Jumped On A Skateboard In NYC, Hilarity Ensued
Entertainment |
How does that sidewalk taste, Biebs?
SHIELD YOUR EYES: Justin Bieber Dyed His Hair Platinum Blonde [PHOTOS]
Entertainment |
Holy s**t
Egging His Neighbor's House Cost Justin Bieber $80,000
Entertainment |
Proves he is a complete idiot


text:
AKRON, Ohio -- The PGA Tour is refuting a report that Dustin Johnson has been suspended.
Johnson said in a statement Thursday he was taking a leave of absence to seek professional help for "personal challenges" that brought an end to his season. Johnson will miss the PGA Championship, the FedEx Cup playoffs and the Ryder Cup.
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Golf.com reported Friday that the tour had suspended Johnson for six months for failing a drug test. The website cited a source it did not identify.
The PGA Tour has a policy of not commenting on disciplinary actions. But it issued a statement Friday afternoon to clarify that Johnson has taken a leave of absence "and is not under a suspension from the PGA Tour."


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Publications (34)266.11 Total impact
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ABSTRACT: Magnetic resonance imaging (MRI) of the knee is often performed in patients who have knee symptoms of unclear cause. When meniscal tears are found, it is commonly assumed that the symptoms are attributable to them. However, there is a paucity of data regarding the prevalence of meniscal damage in the general population and the association of meniscal tears with knee symptoms and with radiographic evidence of osteoarthritis. We studied persons from Framingham, Massachusetts, who were drawn from census-tract data and random-digit telephone dialing. Subjects were 50 to 90 years of age and ambulatory; selection was not made on the basis of knee or other joint problems. We assessed the integrity of the menisci in the right knee on 1.5-tesla MRI scans obtained from 991 subjects (57% of whom were women). Symptoms involving the right knee were evaluated by questionnaire. The prevalence of a meniscal tear or of meniscal destruction in the right knee as detected on MRI ranged from 19% (95% confidence interval [CI], 15 to 24) among women 50 to 59 years of age to 56% (95% CI, 46 to 66) among men 70 to 90 years of age; prevalences were not materially lower when subjects who had had previous knee surgery were excluded. Among persons with radiographic evidence of osteoarthritis (Kellgren-Lawrence grade 2 or higher, on a scale of 0 to 4, with higher numbers indicating more definite signs of osteoarthritis), the prevalence of a meniscal tear was 63% among those with knee pain, aching, or stiffness on most days and 60% among those without these symptoms. The corresponding prevalences among persons without radiographic evidence of osteoarthritis were 32% and 23%. Sixty-one percent of the subjects who had meniscal tears in their knees had not had any pain, aching, or stiffness during the previous month. Incidental meniscal findings on MRI of the knee are common in the general population and increase with increasing age.New England Journal of Medicine 10/2008; 359(11):1108-15. DOI:10.1056/NEJMoa0800777 · 54.42 Impact Factor
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ABSTRACT: Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs). We conducted an analysis of data from the Boston Osteoarthritis of the Knee Study (BOKS). Knee magnetic resonance images were scored for BMLs using a semiquantitative grading scheme. In addition, a subset of persons with BMLs underwent quantitative volume measurement of their BML, using a proprietary software method. Within the BOKS population, 80 people with BMLs and 80 without BMLs were selected for the purposes of this case-control study. Bone biomarkers assayed included type I collagen N-telopeptide (NTx) corrected for urinary creatinine, bone-specific alkaline phosphatase, and osteocalcin. The same methods were used and applied to a nested case-control sample from the Framingham study, in which BMD assessments allowed evaluation of this as a covariate. Logistic regression models were fit using BML as the outcome and biomarkers, age, sex, and body mass index as predictors. An receiver operating characteristic curve was generated for each model and the area under the curve assessed. A total of 151 subjects from BOKS with knee OA were assessed. The mean (standard deviation) age was 67 (9) years and 60% were male. Sixty-nine per cent had maximum BML score above 0, and 48% had maximum BML score above 1. The only model that reached statistical significance used maximum score of BML above 0 as the outcome. Ln-NTx (Ln is the natural log) exhibited a significant association with BMLs, with the odds of a BML being present increasing by 1.4-fold (95% confidence interval = 1.0-fold to 2.0-fold) per 1 standard deviation increase in the LnNTx, and with a small partial R2 of 3.05. We also evaluated 144 participants in the Framingham Osteoarthritis Study, whose mean age was 68 years and body mass index was 29 kg/m2, and of whom 40% were male. Of these participants 55% had a maximum BML score above 0. The relationship between NTx and maximum score of BML above 0 revealed a significant association, with an odds ratio fo 1.7 (95% confidence interval = 1.1 to 2.7) after adjusting for age, sex, and body mass index. Serum NTx was weakly associated with the presence of BMLs in both study samples. This relationship was not strong and we would not advocate the use of NTx as a marker of the presence of BMLs.Arthritis research & therapy 09/2008; 10(4):R102. DOI:10.1186/ar2494 · 4.12 Impact Factor
Article: The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston-Leeds Osteoarthritis Knee Score)[Show abstract] [Hide abstract]
ABSTRACT: Aim: MRI provides unparalleled visualisation of all the anatomical structures involved in the osteoarthritis (OA) process. There is a need for reliable methods of quantifying abnormalities of these structures. The aim of this work was to assess the reliability of a novel MRI scoring system for evaluating OA of the knee and explore the validity of the bone marrow lesion (BML) scoring component of this new tool. After review of the relevant literature, a collaborative group of rheumatologists and radiologists from centres in the UK and USA established preliminary anatomical divisions, items (necessarily broadly inclusive) and scaling for a novel semi-quantitative knee score. A series of iterative reliability exercises were performed to reduce the initial items, and the reliability of the resultant Boston-Leeds Osteoarthritis Knee Score (BLOKS) was examined. A further sample had both the BLOKS and WORMS (Whole Organ MRI Score) bone marrow lesion (BML) score performed to assess the construct validity (relation to knee pain) and longitudinal validity (prediction of cartilage loss) of each scoring method. The BLOKS scoring method assesses nine intra-articular regions and contains eight items, including features of bone marrow lesions, cartilage, osteophytes, synovitis, effusions and ligaments. The scaling for each feature ranges from 0-3. The inter-reader reliability for the final BLOKS items ranged from 0.51 for meniscal extrusion up to 0.79 for meniscal tear. The reliability for other key features was 0.72 for BML grade, 0.72 for cartilage morphology, and 0.62 for synovitis. Maximal BML size on the BLOKS scale had a positive linear relation with visual analogue scale (VAS) pain, however the WORMS scale did not. Baseline BML was associated with cartilage loss on both BLOKS and WORMS scale. This association was stronger for BLOKS than WORMS. We have designed a novel scoring system for MRI OA knee, BLOKS, that demonstrates good reliability. Preliminary inspection of the validity of one of the components of this new tool supports the validity of the BLOKS BML scoring method over an existing instrument. Further iterative development will include validation for use in both clinical trials and epidemiological studies.Annals of the rheumatic diseases 03/2008; 67(2):206-11. DOI:10.1136/ard.2006.066183 · 9.27 Impact Factor
Article: Central bone marrow lesions in symptomatic knee osteoarthritis and their relationship to anterior cruciate ligament tears and cartilage loss.[Show abstract] [Hide abstract]
ABSTRACT: Medial and lateral compartment bone marrow lesions (BMLs) have been tied to cartilage loss. We undertook this study to assess 2 types of BMLs in the central region of the knee (type 1 BMLs, which are related anatomically to anterior cruciate ligament [ACL]/posterior cruciate ligament [PCL] insertions, and type 2 BMLs, which encompass both the central region and either the medial or the lateral compartment) and determine their relationship to cartilage loss and ACL tears. Magnetic resonance imaging (MRI) of the knee was performed at baseline and at followup (15 and/or 30 months) in 258 subjects with symptomatic osteoarthritis (OA). At baseline, we assessed ACL tears and central BMLs located at or between the tibial spines or adjacent to the femoral notch. Cartilage loss was present if the score in any region of the tibiofemoral joint increased by >or= 1 units at the last available followup, using a modified Whole-Organ MRI Score. We used logistic regression adjusted for alignment, body mass index, Kellgren/Lawrence score, sex, and age. One hundred thirty-nine knees (53.8%) had central BMLs, of which 129 had type 1 BMLs (96 abutted the ACL and had no coexistent type 2 features) and 25 had type 2 BMLs (often overlapped with type 1). Type 1 lesions were associated with ACL tears (odds ratio [OR] 5.9, 95% confidence interval [95% CI] 2.2-16.2) but not with cartilage loss (OR 1.6, 95% CI 0.8-3.1), while medial type 2 BMLs were related to medial cartilage loss (OR 6.1, 95% CI 1.0-35.2). Central BMLs that abutted the ACL were highly prevalent and strongly related to ACL pathology, suggesting a role of enthesopathy in OA. Only BMLs with medial extension were related to ipsilateral cartilage loss.Arthritis & Rheumatology 01/2008; 58(1):130-6. DOI:10.1002/art.23173 · 7.87 Impact Factor
Article: Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis[Show abstract] [Hide abstract]
ABSTRACT: To examine the relationship between longitudinal fluctuations in synovitis with change in pain and cartilage in knee osteoarthritis. Study subjects were patients 45 years of age and older with symptomatic knee osteoarthritis from the Boston Osteoarthritis of the Knee Study. Baseline and follow-up assessments at 15 and 30 months included knee magnetic resonance imaging (MRI), BMI and pain assessment (VAS) over the last week. Synovitis was scored at 3 locations (infrapatellar fat pad, suprapatellar and intercondylar regions) using a semiquantitative scale (0-3) at all 3 time points on MRI. Scores at each site were added to give a summary synovitis score (0-9). We assessed 270 subjects whose mean (SD) age was 66.7 (9.2) years, BMI 31.5 (5.7) kg/m(2); 42% were female. There was no correlation of baseline synovitis with baseline pain score (r = 0.09, p = 0.17). The change in summary synovitis score was correlated with the change in pain (r = 0.21, p = 0.0003). An increase of one unit in summary synovitis score resulted in a 3.15-mm increase in VAS pain score (0-100 scale). Effusion change was not associated with pain change. Of the 3 locations for synovitis, changes in the infrapatellar fat pad were most strongly related to pain change. Despite cartilage loss occurring in over 50% of knees, synovitis was not associated with cartilage loss in either tibiofemoral or patellofemoral compartment. Change in synovitis was correlated with change in knee pain, but not loss of cartilage. Treatment of pain in knee osteoarthritis (OA) needs to consider treatment of synovitis.Annals of the rheumatic diseases 01/2008; 66(12):1599-603. DOI:10.1136/ard.2006.067470 · 9.27 Impact Factor
Article: The association between patella alignment and knee pain and function: an MRI study in persons with symptomatic knee osteoarthritis[Show abstract] [Hide abstract]
ABSTRACT: The aim of the study was to examine the association between patellofemoral (PF) alignment (using standard magnetic resonance imaging (MRI) images of extended knees) and knee pain and function. Subjects were recruited to participate in a natural history study of symptomatic knee osteoarthritis, called the Boston Osteoarthritis of the Knee Study (BOKS). The association of predictive variable (patellar alignment in sagittal and transverse planes) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function were examined using a linear regression model while adjusting for age, sex, body mass index (BMI), Center for Epidemiologic Studies Depression Scale (CES-D) score and Kellgren and Lawrence score. Increasing trochlear angle (TA) was associated with both WOMAC (P=0.06) pain and WOMAC function subscale (P=0.04). Increasing lateral patellar title angle (LPTA) and decreasing bisect offset (increasing lateral subluxation) appeared to be associated with increasing WOMAC pain. However, no such an association was observed for other predictors. The findings of the present study suggest that increasing TA is associated with increased functional impairment. Other measures of PF malalignment were not significantly associated with either knee pain or functional impairment.Osteoarthritis and Cartilage 12/2007; 15(11):1235-40. DOI:10.1016/j.joca.2007.04.014 · 4.66 Impact Factor
Article: The association between patellar alignment and patellogemoral joint osteoarthritis features - an MRI study[Show abstract] [Hide abstract]
ABSTRACT: The aim of our study was to evaluate the association between patellar alignment (using standard MRI images of extended knees) and MRI indices of patellofemoral (PF) osteoarthritis (OA) features. In this cross-sectional observational study, subjects were recruited to participate in the Boston Osteoarthritis of the Knee Study (BOKS). The association of patellar alignment [patellar length ratio (PLR), sulcus angle (SA), lateral patellar tilt angle (LPTA) and bisect offset (BO)] with measures of PF OA [cartilage morphology and bone marrow lesion (BML) in the medial and lateral PF compartment] were examined using a logistic regression model while adjusting for age, sex and BMI. Study sample comprised 126 males (mean age 68.0, BMI 31.2) and 87 females (mean age 64.7, BMI 31.6). All measurements of patellar alignment were statistically significantly associated with cartilage morphology and BML in the lateral compartment of PF joint. PLR and SA were significantly associated with medial cartilage loss. With increasing PLR there was an increased prevalence of lateral and medial cartilage loss as well as of lateral BML. Increasing SA was positively associated with increased lateral and medial cartilage loss and lateral BML. LPTA range was negatively associated with lateral cartilage loss and BML. More laterally displaced patella (higher BO) was associated with increased lateral cartilage loss and BML. The results of our study clearly indicated that patellar alignment is associated with manifestations of PF OA such as cartilage thickness loss and BML.Rheumatology 09/2007; 46(8):1303-8. DOI:10.1093/rheumatology/kem095 · 4.44 Impact Factor
Article: The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis[Show abstract] [Hide abstract]
ABSTRACT: The aim of our study was to evaluate the association between patellar alignment by using magnetic resonance imaging images and radiographic manifestations of patello-femoral osteoarthritis (OA). Subjects were recruited to participate in a natural history study of symptomatic knee OA. We examined the relation of patellar alignment in the sagittal plane (patellar length ratio (PLR)) and the transverse plane (sulcus angle (SA), lateral patellar tilt angle (LPTA), and bisect offset (BO)) to radiographic features of patello-femoral OA, namely joint space narrowing and patellar osteophytes, using a proportional odds logistic regression model while adjusting for age, sex, and bone mass index (BMI). The study sample consisted of 126 males (average age 68.0 years, BMI 31.2) and 87 females (average age 64.7 years, BMI 31.6), 75% of whom had tibiofemoral OA (a Kellgren-Lawrence score of 2 or more). PLR showed a statistically significant association with joint space narrowing and osteophytosis in the lateral compartment. SA showed significant association with medial joint space narrowing and with lateral and medial patellar osteophytosis. LPTA and BO showed significant association with both radiographic indices of the lateral compartment. Clear linear trends were found in association between PLR, LPTA and BO, and with outcomes associated with lateral patello-femoral OA. SA, LPTA, and BO showed linear trends of association with medial joint space narrowing. Results of our study clearly suggest the association between indices of patellar alignment and such features of patello-femoral OA as osteophytosis and joint space narrowing. Additional studies will be required to establish the normal and abnormal ranges of patellar alignment indices and their longitudinal relation to patello-femoral OA.Arthritis research & therapy 02/2007; 9(2):R26. DOI:10.1186/ar2138 · 4.12 Impact Factor
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ABSTRACT: Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant vertebrates, which lived some time more than 500 million years ago. Features of ECs that are shared between hagfish and gnathostomes can be inferred to have already been present in this ancestral vertebrate. The goal of this study was to determine whether the hagfish endothelium displays phenotypic heterogeneity. Electron microscopy of the aorta, dermis, heart, and liver revealed ultrastructural heterogeneity of the endothelium. Immunofluorescent studies demonstrated marked differences in lectin binding between vascular beds. Intravital microscopy of the dermis revealed histamine-induced adhesion of leukocytes in capillaries and postcapillary venules, but no such adhesion in arterioles. Together, these data suggest that structural, molecular, and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage.Blood 02/2007; 109(2):613-5. DOI:10.1182/blood-2006-05-026401 · 10.43 Impact Factor
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ABSTRACT: Uncertainty exists regarding the optimal workup of patients with suspected osteomyelitis of the foot, many of whom have diabetes mellitus. We conducted a meta-analysis to determine the diagnostic test performance of magnetic resonance imaging (MRI) for osteomyelitis of the foot and compared this performance with that of technetium Tc 99m bone scanning, plain radiography, and white blood cell studies. We searched MEDLINE (from 1966 to week 3 of June 2006) and EMBASE (from 1980 to week 3 of June 2006) for English-language studies in which adults suspected of having osteomyelitis of the foot or ankle were evaluated by MRI. We then extracted data using a standard form derived from the Cochrane Methods Group. To summarize the performance of diagnostic tests, we used the summary receiver operating characteristic curve analysis, which relies on the calculation of the diagnostic odds ratio (DOR). We also examined subsets of studies defined by the presence or absence of particular design flaws or populations. Sixteen studies met inclusion criteria. In all studies combined, the DOR for MRI was 42.1 (95% confidence interval, 14.8-119.9), and the specificity at a 90% sensitivity cut point was 82.5%. The DOR did not vary greatly among subsets of studies. In studies in which a direct comparison could be made with other technologies, the DOR for MRI was consistently better than that for bone scanning (7 studies-149.9 vs 3.6), plain radiography (9 studies-81.5 vs 3.3), and white blood cell studies (3 studies-120.3 vs 3.4). We found that MRI performs well in the diagnosis of osteomyelitis of the foot and ankle and can be used to rule in or rule out the diagnosis. Magnetic resonance imaging performance was markedly superior to that of technetium Tc 99m bone scanning, plain radiography, and white blood cell studies.Archives of Internal Medicine 02/2007; 167(2):125-32. DOI:10.1001/archinte.167.2.125 · 13.25 Impact Factor
Article: Urinary pentosidine does not predict cartilage loss among subjects with symptomatic knee OA: the BOKS Study.[Show abstract] [Hide abstract]
ABSTRACT: Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major changes in the extracellular matrix of cartilage is the age-related accumulation of advanced glycation end products (AGEs). Pentosidine, an AGE crosslink, is one of the few characterized AGEs and is considered an adequate marker for the many AGEs that are formed in vivo. We used data from a longitudinal observation study to determine if urinary pentosidine could serve as a marker to predict cartilage loss. We conducted a prospective analysis of data from the Boston Osteoarthritis of the Knee Study (BOKS); a completed natural history study of knee OA. All subjects in the study met American College of Rheumatology (ACR) criteria for knee OA. Knee magnetic resonance (MR) images were scored for cartilage in 14 plates of the knee using the Whole Organ Magnetic Resonance Imaging Score (WORMS) semiquantitative grading scheme. Within the BOKS population, a nested sample of 127 subjects (39% of the whole sample) who had both baseline pentosidine and longitudinal magnetic resonance imaging (MRI) measurements (MRIs performed at baseline and 30 months later) was assessed. Urinary pentosidine was assayed and normalized to creatinine to account for differences in urine concentrations. We analyzed the data using three different methods to assess if baseline measures of pentosidine predicted subsequent cartilage loss on MRI. These were (1) analysis 1: logistic regression with the outcome cartilage loss in any plate; (2) analysis 2: proportional odds model where the outcome was defined as 0=no cartilage loss, 1=cartilage loss in one plate, 2=cartilage loss in two plates, and 3=cartilage loss in at least three plates; and (3) analysis 3: Poisson regression with the outcome the number of plates with cartilage loss. All analyses were adjusted for age, sex and Body Mass Index (BMI). At baseline the mean (standard deviation) age was 67 (9) years and 54% were male. The results for the three analytic steps are as follows: Analysis 1: the odds ratio for cartilage loss is 1.01 (95% confidence interval (CI) 0.93-1.09) with 1 unit increase in pentosidine. Analysis 2: the odds ratio for more cartilage loss is 0.99 (95% CI 0.92-1.06) with 1 unit increase in pentosidine. Analysis 3: the relative number of plates with cartilage loss decreased was 1.00 (95% CI 0.95-1.03) with a 1 unit increase in pentosidine. Urinary pentosidine does not predict knee cartilage loss. Previous studies have suggested that local content within cartilage of AGEs is elevated in persons at high risk for progression. Our data suggest that these changes are not measurable systemically. Alternatively, urinary pentosidine levels reflect cartilage degradation in all joints (thus whole body cartilage breakdown) and may therefore not relate to OA severity in a single knee joint.Osteoarthritis and Cartilage 02/2007; 15(1):93-7. DOI:10.1016/j.joca.2006.06.011 · 4.66 Impact Factor
Article: P216 PREVALENCE OF ANTERIOR CRUCIATE LIGAMENT TEAR AND ITS ASSOCIATION WITH KNEE OSTEOARTHRITIS AND "GIVING WAY" AMONG OLDER ADULTS IN THE COMMUNITYOsteoarthritis and Cartilage 12/2006; 14. DOI:10.1016/S1063-4584(07)60668-2 · 4.66 Impact Factor
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ABSTRACT: To explore the relative contribution of hyaline cartilage morphologic features and the meniscus to the radiographic joint space. The Boston Osteoarthritis of the Knee Study is a natural history study of symptomatic knee osteoarthritis (OA). Baseline and 30-month followup assessments included knee magnetic resonance imaging (MRI) and fluoroscopically positioned weight-bearing knee radiographs. Cartilage and meniscal degeneration were scored on MRI in the medial and lateral tibiofemoral joints using a semiquantitative grading system. Meniscal position was measured to the nearest millimeter. The dependent variable was joint space narrowing (JSN) on the plain radiograph (possible range 0-3). The predictor variables were MRI cartilage score, meniscal degeneration, and meniscal position measures. We first conducted a cross-sectional analysis using multivariate regression to determine the relative contribution of meniscal factors and cartilage morphologic features to JSN, adjusting for body mass index (BMI), age, and sex. The same approach was used for change in JSN and change in predictor variables. We evaluated 264 study participants with knee OA (mean age 66.7 years, 59% men, mean BMI 31.4 kg/m(2)). The results from the models demonstrated that meniscal position and meniscal degeneration each contributed to prediction of JSN, in addition to the contribution by cartilage morphologic features. For change in medial joint space, both change in meniscal position and change in articular cartilage score contributed substantially to narrowing of the joint space. The meniscus (both its position and degeneration) accounts for a substantial proportion of the variance explained in JSN, and the change in meniscal position accounts for a substantial proportion of change in JSN.Arthritis & Rheumatology 08/2006; 54(8):2488-95. DOI:10.1002/art.22016 · 7.87 Impact Factor
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ABSTRACT: Our understanding of the local source of pain in osteoarthritis (OA) remains unclear. We undertook this study to determine if the presence of high-signal osteophytes on magnetic resonance imaging (MRI) was associated with pain presence, location or severity. Subjects were chosen from the Boston Osteoarthritis of the Knee Study, a natural history study of symptomatic knee OA. Assessments included knee MRI, pain assessments and information on weight and height. Osteophyte signal was defined as areas of increased signal intensity in the osteophyte on fat-suppressed T2 weighted images, and graded in the joint margins where osteophyte size is graded. All patients were evaluated with the frequent knee symptoms question for pain presence, the Western Ontario McMasters Osteoarthritis Index (WOMAC) for pain severity, and location of self-reported pain was recorded as present or absent based on locations identified on a standardized diagram. The osteophyte signal measures anywhere within one given knee were summed, creating an osteophyte signal aggregate. Logistic regression was conducted with quartile of osteophyte signal aggregate as the independent predictor and frequent knee symptom question as the dependent outcome. Association between quartile of osteophyte signal aggregate and pain severity on WOMAC was assessed using a linear regression. Logistic regression was used to evaluate the association between compartment-specific high-signal osteophytes aggregates (independent variable) and compartment-specific knee pain (dependent variable). Analyses were adjusted for gender, body mass index (BMI), and age. Two hundred and seventeen subjects were included in this analysis. They were predominantly male and 75% of subjects had radiographic tibio-femoral (TF) OA, and the remainder had patello-femoral (PF) radiographic OA. We did not find any association of high-signal osteophytes with presence of pain, pain severity or self-reported pain location. High-signal osteophytes detected on MRI are not associated with the presence of pain, pain severity or the self-reported location of pain.Osteoarthritis and Cartilage 06/2006; 14(5):413-7. DOI:10.1016/j.joca.2005.11.012 · 4.66 Impact Factor
Article: Increase in bone marrow lesions associated with cartilage loss: A longitudinal magnetic resonance imaging study of knee osteoarthritis[Show abstract] [Hide abstract]
ABSTRACT: Although bone marrow lesions (BMLs) are powerful predictors of joint space loss as visualized on radiographs, the natural history of these lesions, their relationship to cartilage loss, and the association between change in these lesions and cartilage loss are unknown. These questions were tested using longitudinal magnetic resonance imaging (MRI) data in a natural history study of symptomatic knee osteoarthritis (OA). MRI of the knee was performed at baseline, 15 months, and 30 months in 217 patients with primary knee OA (122 men, 95 women; mean +/- SD age 66.4 +/- 9.4 years). To assess mechanical alignment, long-limb films were obtained at 15 months. Subchondral bone marrow abnormalities, graded in the medial and lateral tibiofemoral joints, were defined as poorly marginated areas of increased signal intensity in the marrow on fat-suppressed, T2-weighted images. Cartilage morphologic features in the medial and lateral tibiofemoral joints were scored at all time points using a semiquantitative scale. For each of the medial and lateral compartments, generalized estimating equations were used to evaluate the longitudinal relationship of tibiofemoral BMLs to the tibiofemoral cartilage score, with adjustment for malalignment. Fifty-seven percent of knees had BMLs at baseline, of which 99% remained the same or increased in size at followup. Knee compartments with a higher baseline BML score had greater cartilage loss. An increase in BMLs was strongly associated with further worsening of the cartilage score. Enlarging or new BMLs occurred mostly in malaligned limbs, on the side of the malalignment (e.g., new medial BMLs in varus-aligned knees). The association of BML change with medial tibiofemoral cartilage loss was not significant after adjusting for alignment. Lesions of the bone marrow are unlikely to resolve and often get larger over time. Compared with BMLs that stay the same, enlarging BMLs are strongly associated with more cartilage loss. Furthermore, any change in BML is mediated by limb alignment.Arthritis & Rheumatology 05/2006; 54(5):1529-35. DOI:10.1002/art.21789 · 7.87 Impact Factor
Article: The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis[Show abstract] [Hide abstract]
ABSTRACT: To explore the role of meniscal tears and meniscal malposition as risk factors for subsequent cartilage loss in subjects with symptomatic osteoarthritis (OA). Study subjects were patients with symptomatic knee OA from the Boston Osteoarthritis of the Knee Study. Baseline assessments included knee magnetic resonance imaging (MRI) with followup MRI at 15 and 30 months. Cartilage and meniscal damage were scored on MRI in the medial and lateral tibiofemoral joints using the semiquantitative whole-organ magnetic resonance imaging score. Tibiofemoral cartilage was scored on MR images of all 5 plates of each tibiofemoral joint, and the meniscal position was measured using eFilm Workstation software. A proportional odds logistic regression model with generalized estimating equations was used to assess the effect of each predictor (meniscal position factor and meniscal damage as dichotomous predictors in each model) on cartilage loss in each of the 5 plates within a compartment. Models were adjusted for age, body mass index (BMI), tibial width, and sex. We assessed 257 subjects whose mean +/- SD age was 66.6 +/- 9.2 years and BMI was 31.5 +/- 5.7 kg/m2; 42% of subjects were female, and 77% of knees had a Kellgren/Lawrence radiographic severity grade > or = 2. In the medial tibiofemoral joint, each measure of meniscal malposition was associated with an increased risk of cartilage loss. There was also a strong association between meniscal damage and cartilage loss. Since meniscal coverage and meniscal height diminished with subluxation, less coverage and reduced height also increased the risk of cartilage loss. This study highlights the importance of an intact and functioning meniscus in patients with symptomatic knee OA, since the findings demonstrate that loss of this function has important consequences for cartilage loss.Arthritis & Rheumatology 03/2006; 54(3):795-801. DOI:10.1002/art.21724 · 7.87 Impact Factor
Article: A1 CARTILAGE MARKERS AND THEIR ASSOCIATIONWITH CARTILAGE LOSS ON MRI: THE BOSTON OSTEOARTHRITIS KNEE STUDYOsteoarthritis and Cartilage 01/2006; 14. DOI:10.1016/S1063-4584(07)60454-3 · 4.66 Impact Factor
Article: Structural factors associated with malalignment in knee osteoarthritis: the Boston osteoarthritis knee study.[Show abstract] [Hide abstract]
ABSTRACT: Osteoarthritis (OA) is a multifactorial condition. The progression of knee OA is determined in part by mechanical effects on local structures. One of the mechanical influences on cartilage loss is limb alignment. We explored the structural factors associated with malalignment in subjects with symptomatic OA. We conducted a cross-sectional assessment using The Boston Osteoarthritis of the Knee Study, a natural history study of symptomatic knee OA. Baseline assessments included knee magnetic resonance imaging (MRI) and information on weight and height. Long-limb radiographs to assess mechanical alignment were obtained at 15 months. Subarticular bone attrition, meniscal degeneration, anterior and posterior cruciate ligament integrity, medial and lateral collateral ligament integrity, marginal osteophytes, and cartilage morphology were assessed on MRI using a semiquantitative, multi-feature scoring method (Whole-Organ MRI Score) for whole-organ evaluation of the knee that is applicable to conventional MRI techniques. We also quantified the following meniscal position measures on coronal MRI images in both medial and lateral compartments: subluxation, meniscal height, and meniscal covering of the tibial plateau. Using the long-limb radiographs, mechanical alignment was measured in degrees on a continuous scale. The purpose of this cross-sectional analysis was to determine the individual and relative contribution of various structural factors to alignment of the lower extremity. We assessed the cross-sectional association between various structural factors and alignment of the lower extremity using a linear regression model. The 162 subjects with all measures acquired had a mean age of 67.0 years (SD 9.2), body mass index 31.4 (SD 5.6); 30% were female and 77% of knees had a Kellgren-Lawrence grade > or = 2. The main univariate determinants of varus alignment in decreasing order of influence were medial bone attrition, medial meniscal degeneration, medial meniscal subluxation, and medial tibiofemoral cartilage loss. Multivariable analysis revealed that medial bone attrition and medial tibiofemoral cartilage loss explained more of the variance in varus malalignment than other variables. The main univariate determinants of valgus malalignment in decreasing order of influence were lateral tibiofemoral cartilage loss, lateral osteophyte score, and lateral meniscal degeneration. Cartilage loss has been thought to be the major determinant of alignment. We found that other factors including meniscal degeneration and position, bone attrition, osteophytes, and ligament damage contribute to the variance of malalignment. Further longitudinal analysis is required to determine cause and effect relationships. This should assist researchers in determining strategies to ameliorate the potent effects of this mechanical disturbance.The Journal of Rheumatology 11/2005; 32(11):2192-9. · 3.17 Impact Factor
Article: The lateral view radiograph for assessment of the tibiofemoral joint space in knee osteoarthritis - Its reliability, sensitivity to change, and longitudinal validity[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the reliability, validity, and sensitivity to change of tibiofemoral (TF) narrowing on lateral radiographic views. In a natural history study of symptomatic knee osteoarthritis (OA), both lateral view and fluoroscopically positioned posteroanterior (PA) semiflexed view radiographs of the knee in 30 degrees of flexion and with weight bearing were obtained at baseline and at 30 months. Test-retest reliability was evaluated using repeat radiographs, with joint space width measured using electronic calipers. All radiographs were scored on a 0-3 scale, and progression of joint space loss was defined as narrowing of the joint space by 1 grade. We evaluated sensitivity to change compared with the PA view. We evaluated validity by examining whether knees with progression showed expected malalignment on full-limb films. Test-retest reliability of the TF joint space using the lateral view had a root mean square error of 0.303 mm, with 92.5% of repeats within 1 mm. More knees showed progression on the lateral view alone (n = 41) than on the PA view alone (n = 27). Compared with knees without joint space loss, knees with medial compartment loss on the lateral view only were more varus malaligned (P < 0.001), while those with lateral compartment loss were more valgus malaligned (P = 0.008). In the assessment of TF joint space loss, lateral view radiographs are reliable, valid, and more sensitive to change than fluoroscopically positioned PA radiographs.Arthritis & Rheumatology 11/2005; 52(11):3542-7. DOI:10.1002/art.21374 · 7.87 Impact Factor
Article: The relationship between cartilage loss on magnetic resonance imaging and radiographic progression in men and women with knee osteoarthritis[Show abstract] [Hide abstract]
ABSTRACT: To determine the relationship between radiographic progression of joint space narrowing and cartilage loss on magnetic resonance imaging (MRI) in patients with symptomatic knee osteoarthritis (OA), and to investigate the location of MRI-based cartilage loss in the knee and its relation to radiographic progression. Two hundred twenty-four men and women (mean age 66 years) were studied. Radiographs and MRI of the more symptomatic knee were obtained at baseline and at 15- and 30-month followup. Radiographs of the knee (with weight-bearing) were read for joint space narrowing (scale 0-3), with progression defined as any worsening in score. We used a semiquantitative method to score cartilage morphology in all 5 regions of the tibiofemoral joint, and defined cartilage loss as an increase in score (scale 0-4) at any region. We examined the relationship between progression of joint space narrowing on radiographic images and cartilage loss on MRI, using a generalized estimating equation proportional odds logistic regression, adjusted for baseline cartilage score, age, body mass index, and sex. The medial and lateral compartments were analyzed separately. In the medial compartment, 104 knees (46%) had cartilage loss detected by MRI. The adjusted odds ratio was 3.7 (95% confidence interval 2.2-6.3) for radiographic progression being predictive of cartilage loss on MRI. However, there was still a substantial proportion of knees (80 of 189 [42%]) with cartilage loss visible on MRI when no radiographic progression was apparent. Cartilage loss occurred frequently in the central regions of the femur and tibia as well as the posterior femur region, but radiographic progression was less likely to be observed when posterior femur regions showed cartilage loss. Radiographic progression appeared specific (91%) but not sensitive (23%) for cartilage loss. Overall findings were similar for the lateral compartment. While our results provide longitudinal evidence that radiographic progression of joint space narrowing is predictive of cartilage loss assessed on MRI, radiography is not a sensitive measure, and if used alone, will miss a substantial proportion of knees with cartilage loss.Arthritis & Rheumatology 10/2005; 52(10):3152-9. DOI:10.1002/art.21296 · 7.87 Impact Factor
Top Journals
University of Massachusetts Boston
Boston, Massachusetts, United States
- Clinical Epidemiology Research and Training Unit
Boston Medical CenterBoston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
- Center for Vascular Biology Research
Boston University
Boston, Massachusetts, United States
- • Department of Radiology
- • Arthritis Center
VA Long Beach Healthcare SystemLong Beach, California, United States
Minneapolis Veterans Affairs HospitalMinneapolis, Minnesota, United States
Central Arkansas Veterans Healthcare SystemWashington, Washington, D.C., United States


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All posts tagged "Fashion"
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Calvin Klein Joins The L.A. Brigade
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Jennifer Crawford Departs Calvin Klein
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Score! Joan Smalls On Porter
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Marc Jacobs And Cher Duet Again
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Vintage Vid: Anna Wintour's 2009 Letterman Appearance
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Jane Fonda Tells W Why She's A Reluctant Fashion Icon
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The Cannes Film Festival Kicks Off with Sienna, Julianne, and Karlie
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Nicola Formichetti Reveals The Next Big Thing In Social Media
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Giorgio Armani on Muscle Boys, Plastic Surgery, And The Way Gay Men Dress
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David Kind Is Here To Change The Eyewear Game
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Anna Ewers' Biggest Cover Yet
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Swarovski Returns To Broadway In 'Gigi'
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Bradford Shellhammer On His New Venture, Bezar
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Rodarte Fall 2015
Upon entering Center548 for a Rodarte show, there's a palpable sense of anticipation. The sets tend to evoke a mysterious and magical vibe, leaving the audience wondering what Laura and Kate Mulleavy have up their sleeves each season. This time around, it was a glorious mash-up of sumptuous furs, luscious leathers, a bit of cashmere, a healthy dose of lace,


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On schedule and on budget – Olympic chief praises London
Preparations for next year compare favourably with Beijing's efforts, says confident IOC president
Cahal Milmo
Cahal Milmo is the chief reporter of The Independent and has been with the paper since 2000. He was born in London and previously worked at the Press Association news agency. He has reported on assignment at home and abroad, including Rwanda, Sudan and Burkina Faso, the phone hacking scandal and the London Olympics. In his spare time he is a keen runner and cyclist, and keeps an allotment.
Tuesday 26 July 2011
Jacques Rogge, the president of the International Olympic Committee, believes London's preparations leave them as well positioned with a year to go as any recent Games, including the behemoth that was Beijing.
The 2008 Games organisers enjoyed the unparalleled support, funding and resources of the Chinese government and a budget that has been estimated as more than four times that of London's £9.3bn, but Rogge has told The Independent that he regards next year's host city as being in an equally strong position.
"They have done a great job," said Rogge of London's organisers. "We are extremely pleased – it is on schedule and on budget. Quality-wise we are very satisfied. They are very well prepared. In terms of preparation they are on a par with Beijing."
The Olympic Park in London's East End is now 88 per cent complete – the £269m Aquatics Centre will tomorrow be the latest venue to be finished, with Tom Daley due to christen the diving pool live on BBC1. Test events around the city have begun, with the first one in the Park itself scheduled for 16 August in the basketball arena. "It is going to leave a legacy to the city," said Rogge, "bringing new infrastructure, housing and roads – a very strong urban legacy."
Rogge, a former Belgium Olympic sailor who has led the IOC since 2001, said there were no areas of London's preparation that worried him, although the questions over transport and security remain constants at every Games. "There are no particular concerns," Rogge said of London. "There is the eternal concern of traffic circulation but that is valid for all Olympic cities and London appears to have adapted a good strategy.
"Security has been a number one priority for the Olympic movement since Munich in 1972. That is something we must never forget. There must always be good balance – implementation without being too heavy."
There was also high praise yesterday for the state of the host's sporting preparation. At UK Sport's latest briefing on the state of the 28 Olympic and Paralympic sports ahead of the Games, Liz Nicholl, the body's chief executive, expressed growing confidence in their ability to meet the target of a fourth-placed finish in the medals table, as they did in 2008, but with more medals from more sports than Britain won in Beijing. Nicholl said: "We are on track – the current state of play is very positive indeed. British sport is feeling good."
Taking the Olympic sports as a whole, British teams and athletes are further ahead in this stage of the cycle than they were before the 2008 Games, which yielded 47 medals and 19 golds. "It is clear that the mood in the camp across British sport is positive and one of measured confidence," said Nicholl, who cited taekwondo, swimming and cycling as sports that have particularly impressed in recent months. Cycling met their target of winning five to 10 world championship medals with three events in hand – they already have eight - while British taekwondo recently enjoyed its best world championships with four medals.
UK Sport, and its director of performance, Peter Keen, use a traffic light system to indicate the readiness of the Olympic sports under a variety of categories. Currently 11 of the 28 have been given a green rating with none on red. Athletics, in particular, is rated at being in a much stronger position than one year out from Beijing.
Nicholl said: "I am optimistic that, with 12 months to go, British sport could not be in a better place."
Sport blogs
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Arturo Vidal to Real Madrid: Transfer news live - Sergio Ramos to Manchester United, Lukas Podolski to leave Arsenal
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Touring might be tiring, but behind the wheel of a car is no place to nap.
Originally reported as a small fender bender, new reports and pictures reveal that Carlos Santana actually caused massive damage to his car on Monday after apparently falling asleep behind the wheel of his Fisker.
At the time of the accident, Police Lt. Ken Romane called the car crash a 'minor accident' and stated that the incident wasn't 'log worthy.'
Does it look like a minor accident?


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Wildland Fire:
Management Improvements Could Enhance Federal Agencies' Efforts to Contain the Costs of Fighting Fires
GAO-07-922T: Published: Jun 26, 2007. Publicly Released: Jun 26, 2007.
Additional Materials:
- Highlights Page:
- Full Report:
- Accessible Text:
(202) 512-6246
Office of Public Affairs
(202) 512-4800
Annual appropriations to prepare for and respond to wildland fires have increased substantially over the past decade, in recent years totaling about $3 billion. The Forest Service within the Department of Agriculture and four agencies within the Department of the Interior (Interior) are responsible for responding to wildland fires on federal lands. GAO determined what steps federal agencies have taken to (1) address key operational areas that could help contain the costs of preparing for and responding to wildland fires and (2) improve their management of their cost-containment efforts. This testimony is based on GAO's June 2007 report, Wildland Fire Management: Lack of Clear Goals or a Strategy Hinders Federal Agencies' Efforts to Contain the Costs of Fighting Fires (GAO-07-655).
The Forest Service and Interior agencies have initiated a number of steps to address key operational areas previously identified as needing improvement to help federal agencies contain wildland fire costs, but the effects on containing costs are unknown, in part because many of these steps are not yet complete. First, federal firefighting agencies are developing a system to help them better identify and set priorities for lands needing treatment to reduce fuels, but they have yet to decide how they will keep data in the system current. Second, federal agencies have taken some steps to improve how they acquire and use personnel, equipment, and other firefighting assets--such as implementing a computerized system to more efficiently dispatch and track available firefighting assets--but have not yet completed the more fundamental step of determining the appropriate type and quantity of firefighting assets needed for the fire season. Third, the agencies have clarified certain policies and are improving analytical tools that assist officials in identifying and implementing an appropriate response to a given fire, but several other policies limit the agencies' use of less aggressive firefighting strategies, which typically cost less. Fourth, federal agencies, working with nonfederal entities, have recently taken steps to clarify guidance to better ensure that firefighting costs are shared consistently for fires that threaten both federal and nonfederal lands and resources, but it is unclear how the agencies will ensure that this guidance is followed. The agencies have also taken steps to address previously identified weaknesses in their management of cost-containment efforts, but they have neither clearly defined their cost-containment goals and objectives nor developed a strategy for achieving them--steps that are fundamental to sound program management. Although the agencies have established a broad goal of suppressing wildland fires at minimum cost--considering firefighter and public safety and resources and structures to be protected--they have no defined criteria by which to weigh the relative importance of these often-competing priorities. As a result, according to agency officials and reports, officials in the field lack a clear understanding of the relative importance the agencies' leadership places on containing costs and, therefore, are likely to select firefighting strategies without due consideration of the costs of suppression. The agencies have also yet to develop a vision of how the various cost-containment steps they are taking relate to one another or to determine the extent to which these steps will be effective. The agencies are working to develop a better cost-containment performance measure, but the measure may take a number of years to fully refine. Finally, the agencies have taken, or are beginning to take, steps to improve their oversight and increase accountability--such as requiring agency officials to evaluate firefighting teams according to how well they contained costs--although the extent to which these steps will assist the agencies in containing costs is unknown.
Jul 6, 2015
Bureau of Reclamation:Financial Information for Three California Water ProgramsGAO-15-468R: Published: Jun 4, 2015. Publicly Released: Jul 6, 2015.
Jun 24, 2015
Renewable Energy:BLM Has Limited Assurance That Wind and Solar Projects Are Adequately BondedGAO-15-699T: Published: Jun 24, 2015. Publicly Released: Jun 24, 2015.
Jun 9, 2015
Missouri River Basin:Agencies' Progress Improving Water Monitoring Is LimitedGAO-15-558R: Published: Jun 9, 2015. Publicly Released: Jun 9, 2015.
Jun 4, 2015
EPA's Science Advisory Board:Improved Procedures Needed to Process Congressional Requests for Scientific AdviceGAO-15-500: Published: Jun 4, 2015. Publicly Released: Jun 4, 2015.
May 20, 2015
EPA Science Advisory Panels:Preliminary Observations on the Processes for Providing Scientific AdviceGAO-15-636T: Published: May 20, 2015. Publicly Released: May 20, 2015.
May 11, 2015
Forest Restoration:Adjusting Agencies' Information-Sharing Strategies Could Benefit Landscape-Scale ProjectsGAO-15-398: Published: Apr 9, 2015. Publicly Released: May 11, 2015.
May 7, 2015
Hanford Waste Treatment:DOE Needs to Evaluate Alternatives to Recently Proposed Projects and Address Technical and Management ChallengesGAO-15-354: Published: May 7, 2015. Publicly Released: May 7, 2015.
May 6, 2015
Oil and Gas Resources:Interior's Production Verification Efforts and Royalty Data Have Improved, but Further Actions NeededGAO-15-39: Published: Apr 7, 2015. Publicly Released: May 6, 2015.
Apr 16, 2015
Bureau of Land Management:More Information Needed to Implement the Helium Stewardship Act of 2013GAO-15-394: Published: Apr 16, 2015. Publicly Released: Apr 16, 2015.
Mar 23, 2015
Nuclear Waste:DOE Needs to Improve Cost Estimates for Transuranic Waste Projects at Los AlamosGAO-15-182: Published: Feb 18, 2015. Publicly Released: Mar 23, 2015.
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Don't let a bad back get in the way of your love life. 18 comments
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Aussie science
Wednesday, 15 August 2012
Put your knowledge of Aussie science under the microscope.
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In Vitro Fertilization
Friday, 20 June 2003
Explore in vitro fertilization in this interactive.
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Know your enemy
We take a close-up look at 14 human enemies that can kill us, do us harm or just plain annoy us.
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Patent examiner
Tuesday, 15 December 2009
Tim Gillet holds the future of new inventions in his hands. Watch Ace Day Jobs to find out why he became a patent examiner and what the job involves.
Tuesday, 8 December 2009
Kathy Belov's love of science is in her genes. Watch Ace Day Jobs and find out how her work as a geneticist helps Tasmanian devils.