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Garcia says goodbye to Cal State San Marcos
As relaxed as he may appear, Green said, Garcia's a workaholic in disguise. "He has the most energy of anybody I've ever seen," she said, noting he sometimes works too hard but works so hard because he "really enjoys what he does."
Indeed, as the overseer of the budget process, purchasing, human resources, construction planning and facilities management at Cal State San Marcos, Garcia had his work cut out for him. And after he arrived in 2000, he was confronted with an auditor's report from Cal State University headquarters that rendered the opinion that the San Marcos campus failed to adequately manage its assets and resources.
In interviews last week, Garcia said his work and that of his staff since the publication of that report has convinced both the CSU internal auditors and the outside firm of KPMG that the case is closed.
An organizational model Garcia brought to the 7,500-student campus that aims to measure an institution's performance so impressed Paul Niven, the consultant who developed and promoted the approach, that he singled Cal State San Marcos out for special praise in his how-to book, the "Balanced Scorecard." He wrote that he liked how Garcia's staff's use of levity in applying the principles proved "an important ingredient" in the successes at the campus. Garcia gives the credit to staff members such as Katy Rees, an assessment coordinator who helped shaped the model into a tool for, as she put it, understanding "the cause and effect relationship of what we do."
The fiscal house in order
Aside from putting that fiscal house in order, Garcia and the staff shepherded a major spurt in construction at Cal State San Marcos, tripling the square footage of campus buildings. The Clarke Field House, the University Village student apartment complex, the arts and science classroom buildings and the newly opened Kellogg Library, the diamond in the tiara, all opened on schedule and within budget on Garcia's watch -- more than $120 million in new public buildings.
As for Sacramento, Garcia said not only is the fight for access to higher education being waged daily at the Capitol, the Cal State Sacramento campus is poised for what Garcia sees as a massive transformation with a campaign on there to renovate and rejuvenate an aging physical plant. Green and others say it's not hard to imagine that Gonzalez sees Garcia as his go-to guy.
"I just want to do my job and be able to go home and be able to say I did the best I could to do right by the taxpayers," Garcia said over lunch last week in San Marcos.
Growing up
Garcia, who was adopted, grew up on a ranch in the Arizona town of Concho, a remote outpost of some 100 people located about halfway between Phoenix and Albuquerque, N.M., about 30 miles south of the Petrified Forest. As a boy, he would be roused from bed in the summers at 3 a.m. to work the fields before the sun got too oppressive. He learned how to ride horses, brand cattle and lasso and rope calves.


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Listen to free music played by cryostasium
Blip.fm is internet radio made social. It's easy to search for, play, and discover free music recommended by real people. Join today to create your own free station and start listening to @cryostasium.
cryostasium @mmemaledicta HOLY FUCK this is like those newsom moments you are talking about....

subset: commoncrawl


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Nice picture but this is actually in the old part of town and not in Kato Paphos.
Correct, I 'll change it in Panoramio. I knew there are two parts of Paphos but was not shore wich part of the town Kato was. Now I know, thanks!
Very nice shot.. LIKE.
Thank you Fuat, I'm glad you like it. Greetings, Bart.
Photo taken in Moutallos, Paphos, Cyprus
Moutallos Mosque


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|Thread Tools
Sila- Yes, we will freeze whatever makes it that far. We are only transferring one.
SSB- Wonderful Beta! So exciting. I'll be praying this is your rainbow baby!
SKJ- I know you've already heard it from me but I'll post it here just for good measure. This is so unfair and I really hope they find some sort of answer for you at the RPL specialist.
Sila- Come on ovulation.... Make a good egg already damnit.
Brichole- Hoping for good news Friday! Any encouraging signs??
AFM- I had the stomach flu yesterday so I'm still feeling pretty crummy. It was nearly the worst day ever... Good news is, tonight is my last BCP and my supporession check is less than a week away!!!!!
C + B + 10y together, 6y married, 5y TTC endometriosis, Hashimoto's thyroiditis, 4 miscarriages
IVF x3, FET x3 & IVF wPGD FETx1 gave us our miracle twins (and 4 frosties)
Never give up on a dream just because of the time it will take to accomplish it. The time will pass anyway.
SKJ - So sorry to hear that. Hopefully the specialist will be helpful.
Have any of you heard of the Mirena IUD causing infertility problems? Let me start by saying I know this may be a straw I am grasping at here... Yesterday I saw a commerical for 1-800-bad-drug that was about Mirena causing problems for women including a lot of severe symptoms but one that was mentioned was miscarriage and infertility after having it. This makes me curious if I am experiencing this. I had Mirena for 5+ years after my first DD, had it taken out, got pregnant with DD #2 on the second cycle after. Then, I had a new Mirena put in after DD #2. That one I took out after about 1.5 years. I've had a miscarriage and no pregnancy since. I wonder if it's worth looking in to???
Me - 31, DH - 35, DD#1 11, DD#2 6 MC 2/11 MC 1/12 DS#1 3/14
planegreen- It can't hurt to call and ask anyway. It won't heal your infertility but at least if there was a problem with the drug that has caused you so much trouble you can feel justified. Good luck!
SKJ - I'm so, so sorry. I really hope the recurrent loss specialist has some clear answers for you. This is not fair and nobody should have to go through what you are. Much love to you.
Nikki , partner to Jeremy . Baby Joshua Nolan is finally here after a many year struggle with infertility. I blog at www.loliecraft.blogspot.com.
Warning... TMI coming...
So... My period finally showed up today. 4 days after stopping the progesterone. What's even stranger is that on the same tissue with the first spot of blood was a small clump of mucous. I'm wondering if it was the beginnings of a mucous plug. Maybe I had an early loss? I did have a wierd pregnancy test a few days ago (11dpo)...
43 w/Emphysema - TTC from 2005 - 2013. 2 miscarriages in 2008. Good things do not come to those who wait.
Hi all! We have been really busy as our 3yr old had a birthday on Monday :)
Went in for testing on Monday, and had an ultra sound, no AF, said I had ovulated and healthy count of foliciles on each side. Weird I ovulated with no period! Waiting for AF, if none by Friday going in on Monday again, which will be day 62.
Hope everyone is happy that the holidays are near! Cheering for those that need it. Hugs for those that need it!
Mom to DS 12/07 and DD 11/13, plus a bunch of chickens, dogs, and cats.
Moving past many years of infertility and always thinking of my friends in the infertility forums.
SSB - :) Awesome beta #. Hope to only hear more good news from you!
Hope to more good news over here soon! It's time for a run of BFPs!!!!!!!!!!!
So sorry, SKJ. AFM- Transfer went very well. We had a gorgeous embryo we transferred and another that was almost as gorgeous that will be frozen. We have one more that is definitely being frozen and another they are watching. Currently lying in bed, about to nap.
SKJ - Again, I am so sorry. It really sucks.
Deborah - Awesome!
Darlawoods - Hoping AF doesn't come and you get a bfp instead :)
AFM - Come on egg....
Married to my love , Mommy to W ('09) and Doula.
God has answered our prayers & we welcomed our baby girl earth side 11/24/13
Cait - thank you so much! I really hope this is the one.
I'm sorry you've been so sick. Hurray for no more BCP though! It's not too much longer now.
Stevi - I'm so sorry.
darla - I hope AF shows up! Thanks for the cheers and hugs.
wissa - thank you! I really hope there is a run of BFPs for everyone here.
Sila - come on eggie! I'm crossing everything for you.
Nikki , partner to Jeremy . Baby Joshua Nolan is finally here after a many year struggle with infertility. I blog at www.loliecraft.blogspot.com.
Hi Everyone-- poking my head in. We have been NTNP (due to DH's not being able to finish under pressure, we can't time our BDs very easily) since August of last year. I got pregnant in May and lost it around 8 weeks. Other than that, no pregnancies and no signs that either of us have a medical condition.
One doctor thought my thyroid was off but further testing showed it to be normal. Hormone levels are normal. My cycles are regular and temping leads me to believe that I am ovulating. DH is very healthy too, but hasn't been tested for sperm quality or quantity. I have an ultrasound scheduled soon since my sisters have PCOS-- no symptoms for me but they said it was best to check my ovaries since it runs in the family.
We tend to BD about once a week so we miss ovulation pretty regularly. I hope the reason we are not getting pregnant is that simple. Since I was pregnant in May we aren't technically dealing with infertility, but the months are dragging by and the lost baby's due date is coming up and I am incredibly sad. I am 32 and DH is 34.
I've heard that too.. I did not see the results of the most recent workup but the nurse said it was a full thyroid panel. I will be sure to ask when I go in for the US. Honestly my symptoms are not too bad... I am on the heavy side, kind of slow moving, low blood pressure, dry skin and hair, but almost all of that runs in the family. Plus I have textured hair-- that's just dry in general.
lilag... inter-uterine-insemination. It's artificial insemination where the sperm is placed near the cervix in the vagina.
Ooops... Yeah, it's also where washed sperm is injected into the uterus. The term is used so much for the cervical procedure that I tend to forget about the procedure the name originally referred to.
43 w/Emphysema - TTC from 2005 - 2013. 2 miscarriages in 2008. Good things do not come to those who wait.
Sending out Hugs to those who need them this week! I am in a state of numbness right now so i probably won't have time for much.
AF showed up this morning as soon as I woke up at 530. So we are out. DH is still saying he doesn't know if he wants us to do medicated cycles again so I'm going to just work on losing the weight that I want to lose and see if that will help with my PCOS since nothing else seems to be able to explain my PCOS. I will still be here to encourage everyone and i'm praying that everyone here is able to have the babies they dream of each night soon! Love all of you ladies!
Brandy(28) mommy to Jayde (12/14/03) and Emma Mattilynn-Gail born 12/06/10 and Loving wife to DH (32)! TTC#3 since April 2011! Missing our little s that we lost so early 7/11 & 11/11! Praying to get our soon!
Hugs to you brichole.
Aww brichole I am so sorry. I hope you get your take home baby soon and your DH changes his mind.
Hugs Brichole and SKJ
TeamViddy - Can you chart "secretly"? I know that sounds bad but if your DH had troubles under pressure, is there a way that you could make it so that he doesn't know it's O time? I know it's not that simple but just an idea...
AFM - Nada. Just hangin' out. I turn 30 on Thursday and expect AF shortly after. Won't that be a nice birthday present?
Me - 31, DH - 35, DD#1 11, DD#2 6 MC 2/11 MC 1/12 DS#1 3/14
Hugs PlaneGreen. AFM- No vomiting so far today, but definitely some nausea. I vomited twice yesterday (I'm sure you all needed to know that). I found out why though. My progesterone was 54.3 today. The nurse said my number is awesome and she's feeling positive vibes for me. I looked and my number with the boys at 7 weeks was less than double that. Granted, I was doing vagina progesterone support, not IM but it is still very promising.
Plus, this better all be worth it!
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text:
70,500 spectators (throughout the weekend) witnessed another flawless race of the leader of the standings and an impressive showing of the entire Audi squad at the venue near Magdeburg. All eight Audi RS 5 DTM cars finished in the top ten and thus in the points – a premiere.
Before the race at Oschersleben, eight drivers still had title chances. Now, only two are left: Rockenfeller and Farfus. The Brazilian was the only rival Rockenfeller had to admit defeat to. "He was extremely strong today," commented the Audi driver. "On the option tires I was running relatively fast while things weren't going quite as well on standard tires – that's why I'm particularly pleased with second place and the important points we scored here again."
Rockenfeller started on harder standard tires and in the early phase initially dropped back to fourth place. On the softer option tires, he subsequently improved to position two and brought the 18 points for the Championship home in typical, commanding style.
Jamie Green in the Red Bull Audi RS 5 DTM of Audi Sport Team Abt Sportsline achieved his first podium result as an Audi driver. The Briton made a good start but in the narrow first turn had to yield to the subsequent winner Farfus. After his second pit stop he hit the track again directly behind Rockenfeller and crossed the finish line in third place right behind the leader of the standings.
For the first time in the points this season was Filipe Albuquerque, who in the Audi Financial Services RS 5 DTM of Audi Sport Team Rosberg drove a strong race which he finished in fourth place. In fifth place, Timo Scheider in the AUTO TEST Audi RS 5 DTM managed to score his best result of the season as well. The two-time DTM Champion showed remarkable overtaking maneuvers, battling his way forward from ninth on the grid to fifth and thus into the top ten.
Even more cars were overtaken by Mattias Ekström, who in his Red Bull Audi RS 5 DTM chose a different strategy than most of the other drivers, initially fitting standard tires twice. Toward the race's midpoint the Swede switched to option tires and subsequently recovered one position after another. Having started from grid position 13, Ekström thus finished in seventh place.
Miguel Molina (Audi RS 5 DTM), Adrien Tambay (Audi ultra RS 5 DTM) and Edoardo Mortara (Playboy Audi RS 5 DTM), who initially had stopped at the start and dropped to the last position in the field, in eighth, ninth and tenth place completed the impressive Audi performance.
Dieter Gass, Head of DTM at Audi Sport, was pleased accordingly, as he commented: "This was the solid team performance we'd been wishing for. All eight Audi RS 5 DTM cars in the points – that's never happened before. Obviously, we'd have liked to have won the race here as well but, more importantly, Mike Rockenfeller made another big step forward in the Championship. He's now got an advantage of 33 points and only one rival left. But there are 50 points yet to be awarded. We're going to continue to work with concentration in order to clinch the title."
In just two weeks from now, at Zandvoort (Netherlands), the next race will be on the agenda. There, Mike Rockenfeller could secure an early title win. In the manufacturers' standings, Audi, after the strong result achieved at Oschersleben, has a score of 267 points, trailing BMW (276) by only nine points and clearly ranking ahead of Mercedes-Benz (237).
– End –
All eight Audi RS 5 DTM cars in the top ten
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Audi A4 Emotion Trailer - ExtendedDie neuen Audi A4 und der A4 Avant legen mit zahlreichen Highend-Technologien die Messlatte in der Klasse höher. Elegantes Design trifft auf ein innovatives Bedienkonzept, konsequenter Leichtbau auf effiziente Lösungen beim Antrieb. Auch beim Infotainment und bei den Assistenzsystemen führen A4 und A4 Avant den Wettbewerb an. Weitere Informationen zum neuen Audi A4 finden Sie im Audi MediaCenter: https://www.audi-mediacenter.com/de
Audi A4 Emotion TrailerDie neue Generation der Bestseller-Familie A4 wurde auf sämtlichen Technikfeldern neu entwickelt. Das Ergebnis: Niedrige Emissionen, beste cw -Werte, wegweisende Technologien in Sachen Infotainment sowie die größte Auswahl im Wettbewerb bei Fahrerassistenz- und Sicherheitssystemen. Weitere Informationen zum neuen Audi A4 finden Sie im Audi MediaCenter: https://www.audi-mediacenter.com/de
Die Weltpremiere des neuen Audi A4Mit der exklusiven Premiere zeigen die Vier Ringe der Weltöffentlichkeit die nächste Generation der Audi-Bestseller Audi A4 Avant und Audi A4 Limousine. Weiteres Bewegtbildmaterial stellen wir Ihnen im Audi MediaCenter zur Verfügung: http://bit.ly/1Jj2MGD.
- Audi scores points at Oschersleben with all eight cars
- Mike Rockenfeller makes further step toward the title
- Jamie Green on podium for the first time with Audi
With a second-place finish at Oschersleben Mike Rockenfeller (Schaeffler Audi RS 5 DTM) has made another big step toward the Champion's title. Before the last two races at Zandvoort and Hockenheim the driver from Audi Sport Team Phoenix has a 33-point advantage over Augusto Farfus (BMW).


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Cable car at Samsun and hills of Amisos
There is a cable car adventure :) to Amisos hills at Samsun. Ýt takes you to tumuli of Baruthane where you can visit the archaeological park. Hills offer you a great view of Blacksea. Also there is a nice restaurant&cafe called Amisos with a stunning view. The place provides delicous food, reasonable prices and sea view... what else we need :)
During your visit you'll see two tombs in the archaeological park dated 4th century B.C. unfortunately ancient tomb robbers havent left them alone :(
Cable car ticket is 2 TL (return ticket-u need to keep ur ticket) =1 Euro
- Historical Travel
- Archeology
- Architecture
Samsun has long sandy beaches...
Samsun has long sandy beaches in both western and eastern sides. If you do not like to spend all your holiday at the seaside i recommend you mountainous areas. Nowadays it is possible to go to hills by car. But discovering our unique nature by climbing or walking is a better way. A break near a fountain or stream, smells of grass, wild flowers and thyme will surround you with love. Here is a good itinerary:Go to Duvecik village(8 kms southeast of Samsun-Other side of Mert river) then continue to walk to hills you see. When you arrive the top, a nice scenery will meet you. Now you can enjoy looking down the Yilanlidere(Snake Stream) valley.
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Co-presented by Théatre de la Ville and the Aga Khan Music Initiative
Paris, 7 October 2011 -- The Aga Khan Music Initiative and Théatre de la Ville team continue their three-year partnership with a two-day celebration of Pakistani music and poetry at the Théatre de la Ville in Paris on the 8th and 9th of October 2011.
The weekend, featuring 20 Baluchi, Sindhi and Pashtun musicians and poets, will begin with readings of the folk stories and popular poetry of the nomads of Baluchistan. Sindhi master of the double flute Akbar Khamisu Khan will be accompanied on dholak by Mohamed Khan. Baluchi musicians include Mohammad Bashir and the singer Nawab Khan. Zarsanga, the queen of Pushtun music, will recite love poems called landays and other nomadic kuchi songs accompanied by her son Shahzad on tabla and Muhabat Khan on rubab. On 9 October, the vibrant Sufi poetry tradition will be explored. Through music and stories, the programme will highlight Sufi poetry's function as a means of invoking and connecting with the transcendent. A special focus will be on the Qawwali tradition inspired by Hazrat Amir Khusraw and made famous by Nusrat Fateh Ali Khan at a Théatre de la Ville concert in 1985.
A full programme is available at: http://www.theatredelaville-paris.com/
The Aga Khan Music Initiative (www.akdn.org/music) is a nine-country music and arts education programme, with a worldwide performance and production activities. Launched in 2000 by His Highness the Aga Khan to support talented musicians and music educators who are striving to preserve, transmit, and further develop their musical heritage in contemporary forms, the Music Initiative began its work in Central Asia, eventually expanding to include musicians and artistic communities from the Middle East, North Africa, and South Asia. Since its inception, the Initiative has helped musicians, music educators and grassroots cultural strategists to recast musical traditions of the Silk Route in contemporary forms and contexts rooted in local cultural heritage.
For more information, please contact:
Aga Khan Music Initiative (AKMI)
Fairouz R. Nishanova Director, AKMICA
Aga Khan Trust for Culture
P.O. Box 2049 1211
Geneva 2 Switzerland
E-mail: email@example.com
Theatre de la Ville
Jacqueline Magnier
Presse & Documentation
Tél: 01.48.87.84.61
16,Quai de Gesvres
75180 Paris Cedex04
Email: firstname.lastname@example.com
Quick links
What's new
30 June 2015
Azito Energie Inaugurates Côte d'Ivoire's First Operational Combined Cycle Gas Turbine (CCGT) Power Plant
18 June 2015
Inauguration of the Ayyubid Wall and Tarabay al-Sherif Complex Projects in Cairo
15 June 2015
Om Habibeh Foundation and Aswan Directorate of Agriculture to Support 5,000 Farmers
03 June 2015
Historic Agreement Establishes Global Seat of Ismaili Imamat in Portugal
25 May 2015
Toronto's Newest Cultural Hub, the Aga Khan Park, Is Opened
© 2007 The Aga Khan Development Network. This is the only authorised Website of the Aga Khan Development Network.


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Milan hotels with Pool
Find a variety of discounted Milan hotels available with Pool. There are 12 hotels with Pool available for booking in Milan through HotelClub. Milan hotels with Pool are also well known for their Amenities and Hotel Staff
12 hotels with Pool in Milan
1 BEST WESTERN Hotel Galles
Piazza Lima 2 Map
Elegant and practical, Galles Hotel Milan offers a full range of facilities and essential services for a truly comfortable stay. GeneralThe hotel has a hanging garden on the 1st floor and a sun... More
2 Novotel Milano Malpensa Airport
Via Al Campo Map
Offering luxurious modern living in sophisticated and understated elegant surroundings, Novotel Hotel Milano Malpensa Airport pampers you with every comfort and services for a splendid stay. ... More
3 Sheraton Milan Malpensa Airport Hotel & Conference Centre
Malpensa Terminal 1 S.S. 336 Map
Sheraton Milan Malpensa Airport Hotel & Conference Centre with its comfortable accommodation and friendly hospitality offers a wide range of facilities and services for its guests. This hotel... More
4 Novotel Milano Linate Aeroporto
Via Mecenate 121 Map
Creating an ideal atmosphere for a relaxing stay, Novotel Hotel Milano Linate Airport is the right choice of accommodation, while visiting Milan. GeneralThis property also offers meeting rooms to... More
5 Holiday Inn MILAN - ASSAGO
Tangenziale Ouest Km 19 Map
Situated in a strategic position, this property is an ideal place for business or leisure travellers and for those who want to explore the city. GeneralThe 17 well-equipped meeting rooms that can... More
6 Radisson Blu Hotel Milan
Via Villapizzone 24 Map
Offering comfortable accommodation and quality services, this property is an ideal place for a pleasant and enjoyable vacation. GeneralBusiness travellers can make use of the conference... More
7 SINA De La Ville Hotel Milan
Via Hoepli 6 Map
Set close to the Duomo and Scala, the De La Ville Hotel is a comfortable and tranquil place, perfect for a stay or for meetings. GeneralThe meeting centre at the hotel provides maximum privacy for... More
8 Novotel Milano Nord Ca Granda
Viale Suzzani 13 Map
The Novotel Hotel Milano Nord Ca Granda Milan, which is known for its excellent accommodation, friendly staff and central location is ideal for both business as well as leisure travellers. ... More
9 BEST WESTERN Jet Hotel
Via Tiro A Segno 22 Map
BEST WESTERN Jet Hotel Gallarate is a cosy, quiet and an ideal oasis, for anyone who is seeking rest after a long flight or a busy working day. GeneralThe BEST WESTERN Jet Hotel Gallarate also... More
10 BEST WESTERN Hotel Cavalieri Della Corona
Via Baroldo, 12 Map
Featuring comfortable accommodations in a central location, Novum Hotel Primus Frankfurt makes for an ideal base for business and leisure travellers visiting Frankfurt. Tourists at this... More
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Monmouth Junction Dayton Rd, Monmouth Junction, NJ 08852
Phone: (732) 438-0918
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|Home | About | Journals | Submit | Contact Us | Français
Alzheimer's Disease Education and Referral Center, PO Box 8250, Silver Spring MD 20907-8250, Phone: 800-438-4380; 301-495-3334, Fax: 301-495-3334, Email: adear/at/alzheimers.org, www.alzheimers.org
National Library of Medicine Genetics Home Reference, Alzheimer Disease
NCBI Genes and Disease, Alzheimer Disease
National Institute on Aging, Building 31 Room 5C27, 31 Center Drive MSC 2292, Bethesda MD 20892, Phone: 301-496-1752, Email: karpf/at/nia.nih.gov, www.nia.nih.gov
Alzheimer's disease (AD) is the most common cause of dementia and represents a major public health problem. The neuropathological findings of Aβ amyloid plaques and tau containing neurofibrillary tangles represent important molecular clues to the underlying pathogenesis. Genetic factors are well recognized, but complicated. Three rare forms of autosomal dominant early onset familial AD have been identified and are associated with mutations in APP (amyloid precursor protein), PS1 (presenilin 1) and PS2 (presenilin 2) genes. The more common late onset form of AD is assumed to be polygenic/multifactorial. However, thus far the only clearly identified genetic risk factor for AD is Apo lipoprotein E. The ε4 allele of ApoE influences age at onset of AD, but is neither necessary nor sufficient for the disease. The search continues for the discovery of additional genetic influences.
The clinical manifestation of Alzheimer disease (AD) is dementia that typically begins with subtle and poorly recognized failure of memory and slowly becomes more severe and, eventually, incapacitating. Other common findings include confusion, poor judgment, language disturbance, agitation, withdrawal, and hallucinations. Occasionally, seizures, Parkinsonian features, increased muscle tone, myoclonus, incontinence, and mutism occur1.
Death usually results from general inanition, malnutrition, and pneumonia. The typical clinical duration of the disease is eight to ten years, with a range of from one to 25 years.
Establishing the diagnosis of Alzheimer disease relies upon clinical-neuropathologic assessment1. Neuropathologic findings on autopsy examination remain the gold standard for diagnosis of AD. The clinical diagnosis of AD (prior to autopsy confirmation) is correct about 80%-90% of the time2.
Differential diagnosis of Alzheimer disease includes other causes of dementia, especially treatable forms of cognitive decline, such as depression, chronic drug intoxication, chronic CNS infection, thyroid disease, vitamin deficiencies (especially B12 and thiamine), CNS angitis, and normal-pressure hydrocephalus1.
Other degenerative disorders associated with dementia, such as frontotemporal dementia including frontotemporal dementia with parkinsonism-17 (FTDP-17), Picks disease, Parkinson disease, diffuse Lewy body disease (LBD), Creutzfeldt-Jakob disease, and CADASIL, may also be confused with AD7.
CT and MRI are valuable for identifying some of these other causes of dementia, including neoplasms, normal-pressure hydrocephalus, frontotemporal dementia and cerebral vascular disease.
AD is the most common cause of dementia in North America and Europe, with an estimate of four million affected individuals in the US.
The prevalence of AD increases with age. Mild memory loss is often call mild cognitive impairment (MCI). In many persons MCI is considered an early stage of Alzheimer's disease.
The incidence of AD rises from 2.8 per 1,000 person years in the 65-69 year age group to 56.1 per 1,000 person years in the older than 90 year age group8. Approximately 10% of persons over age 70 years have significant memory loss and more than half of these individuals have AD. An estimated 25%-45% of persons over age 85 years have dementia.
About 1%-6% of all Alzheimer disease (AD) is early onset (before age 60-65 years) and about 60% of early-onset AD is familial, with 13% appearing to be inherited in an autosomal dominant manner9,10.
The distinction between early-onset familial Alzheimer disease (onset before age 60-65 years) and late-onset familial Alzheimer disease (onset after age 60-65 years) is somewhat arbitrary. Early-onset cases can occur in families with generally late-onset disease11.
No environmental agents (e.g., head trauma, viruses, toxins, low education level) have been proven to be directly involved in the pathogenesis of AD. It is often speculated that late-onset AD is the result of unknown environmental factors acting on a predisposing genetic background12. Twin studies have implicated both genes and environment13.
Essentially all persons with Down syndrome (trisomy 21) develop the neuropathologic hallmarks of AD after age 40 years. More than half of individuals with DS also show, if carefully observed or tested, clinical evidence of cognitive decline14. The presumed reason for this association is the lifelong over-expression of the APP gene on chromosome 21 encoding the amyloid precursor protein and the resultant overproduction of β-amyloid in the brains of persons who are trisomic for this gene.
The amyloid-β (Aβ) deposition in the brain may begin in the first decade of life in persons with DS15. AD was not noted clinically or pathologically in a 78-year-old woman with partial trisomy 21 who did not have an extra copy of the APP gene16. Two studies have found no association of Apo E genotype with age of onset of dementia in Down syndrome17,18, but one study did find an association of onset age with a polymorphism in the APP gene18. Schupf et al19 found an unexplained increased risk for AD in mothers who gave birth to children with DS prior to age 35 years.
About 25% of AD is familial (i.e., two or more family members have AD). Familial cases appear to have the same clinical and pathologic phenotypes as non-familial cases (i.e., an individual with AD and no known family history of AD)20, 21 and are thus distinguished only by family history or by molecular genetic testing. A large volume of research on the molecular and genetic basis of AD has been summarized by Rosenberg22, Sleegers & Van Duijn23, Nussbaum & Ellis24, Goedert & Spillantini25, and Roses & Saunders26.
Many families have multiple affected members, most or all of whom have onset of dementia after age 60 or 65 years. Disease duration is typically eight to ten years, but ranges from two to 25 years. Investigations have supported the concept that late-onset AD is a complex disorder that may involve multiple susceptibility genes (reviewed and summarized by Kamboh27, Bertram & Tanzi28, Serretti et al29, and Roses & Saunders26). Bertram et al30 have performed a meta-analysis on these data. The following information is currently available:
Individuals with non-familial AD meet the diagnostic criteria for AD and have a negative family history. Onset can be anytime in adulthood. The exact pathogenesis of the disease is unknown. A common hypothesis is that non-familial AD is multifactorial and results from a combination of aging, genetic predisposition, and exposure to one or more environmental agents, such as head trauma, viruses, and/or toxins65 although no environmental agents have been proven to be directly involved in the pathogenesis of AD.
A three-generation family history with close attention to the history of individuals with dementia should be obtained. For each affected individual, the age of onset of dementia should be noted. Generally, individuals with onset before age 65 years are considered to have early-onset Alzheimer disease (AD) and those with onset after age 65 years are considered to have late-onset AD. Medical records of affected family members, including reports of neuroimaging studies and autopsy examinations, should be obtained.
Late-onset familial AD. The association of one or two copies of the APOE allele e4 (i.e., genotypes e2/e4, e3/e4, e4/e4) with late-onset Alzheimer disease (AD) is well documented (Table 4) 32, 66, 67.
The usefulness of APOE genotyping in clinical diagnosis and risk assessment remains unclear [Statements and Policies Regarding Genetic Testing].
There is some evidence that the APOE e2 allele may have a protective effect in regard to risk for AD (Table 4).
Another way to look at this association between AD and an APOE e4 allele is with APOE e4 allele frequencies (Table 5).
The three known subtypes of EOFAD, called AD3, AD1, and AD474, 75 can only be distinguished by molecular genetic testing (Table 3). Genetic testing of individuals who are simplex cases (i.e., a single occurrence of early-onset AD in a family) is controversial and should be undertaken in the context of formal genetic counseling76. A small proportion (<5%) of such cases will have a mutation in PS1.
Because Alzheimer disease (AD) is genetically heterogeneous, genetic counseling of persons with AD and their family members must be tailored to the information available for that family. AD is usually considered polygenic and multifactorial. Early-onset familial Alzheimer disease is inherited in an autosomal dominant manner.
Genetic counseling for people with non-familial AD and their family members must be empiric and relatively nonspecific. It should be pointed out that AD is common and that the overall lifetime risk to any individual of developing dementia is approximately 10%-12%.
First-degree relatives of a person with AD have a cumulative lifetime risk of developing AD of about 15%-30%, which is typically reported as a 20%-25% risk77, 78. This risk is about 2.5 times that of the background risk (~27% vs 10.4%)79, 80.
Disagreement exists as to whether the age of onset of the affected person changes the risk to first-degree relatives. One study found that early-onset AD increased the risk78, while another study did not77.
The number of additional affected family members probably increases the risk to close relatives, but the magnitude of that increase is unclear unless the pattern in the family is characteristic of autosomal dominant inheritance. Having two, three, or more affected family members probably raises the risk to other first-degree relatives in excess of that noted above for non-familial cases, although the exact magnitude of the risk is not clear. Heston et al81 found a 35%-45% risk of dementia in individuals who had a parent with AD and a sib with onset of AD before age 70 years. Jayadev et al82 also report data suggesting that offspring of parents with conjugal AD (i.e., both parents affected) had an increased risk of dementia.
Many individuals diagnosed as having early-onset Alzheimer disease have another affected family member, although family history is negative 40% of the time10. Family history may be "negative" because of early death of a parent, failure to recognize the disorder in family members, or, rarely, a de novo mutation. The risk to sibs depends upon the genetic status of the affected proband's parent. If one of the proband's parents has a mutant allele, then the risk to the sibs of inheriting the mutant allele is 50%. Individuals with early-onset familial Alzheimer disease (and a mutation in APP, PS1 or PS2) have a 50% chance of transmitting the mutant allele to each child. The risk to other family members depends upon the status of the proband's parents. If a parent is found to be affected, his or her family members are at risk.
Use of APOE genotyping for predictive testing. In contrast to the utility of APOE testing as an adjunct diagnostic test in individuals with dementia, there is general agreement that APOE testing has limited value used for predictive testing for AD in asymptomatic persons. Data suggest that a young asymptomatic person with the APOE e4/e4 genotype may have an approximately 30% lifetime risk of developing AD83. Further refinement of this risk reveals that females with an APOE e4/e4 genotype have a 45% probability of developing AD by age 73 years, whereas males have a 25% risk71. These risks are lower — and the likely age of onset later — for persons with only one APOE e4 allele (peak age 87 years) or no APOE e4 allele (peak age 95 years). These estimates are not generally considered clinically useful; however, a research study to assess the potential utility of APOE testing in relatives of individuals with late-onset AD is under way79, 84.
Down syndrome. Family members of persons with Down syndrome are not at increased risk for AD.
Preliminary results have shown that while relatively few family members choose such testing, they usually cope well with the results, which can affect personal relationships and emotional well-being85. However, significant depression following such testing has been reported86.
Testing of at-risk individuals during childhood. Consensus holds that individuals at risk for adult-onset disorders should not have testing during childhood in the absence of symptoms. The principal arguments against testing asymptomatic individuals during childhood are that it removes their choice to know or not know this information, it raises the possibility of stigmatization within the family and in other social settings, and it could have serious educational and career implications.
Prenatal diagnosis for pregnancies at increased risk for mutations in the presenilin 1 (PSEN1) gene is possible by analysis of DNA extracted from fetal cells obtained by amniocentesis usually performed at about 15-18 weeks' gestation or chorionic villus sampling (CVS) at about ten to 12 weeks' gestation. The disease-causing allele of an affected family member must be identified before prenatal testing can be performed. No laboratories offering molecular genetic testing for prenatal diagnosis of EOFAD caused by APP or PSEN2 mutations are listed in the GeneTests Laboratory Directory. However, prenatal testing may be available for families in which the disease-causing mutation has been identified.
Requests for prenatal diagnosis of adult-onset diseases are uncommon. Differences in perspective may exist among medical professionals and within families regarding the use of prenatal testing, particularly if the testing is being considered for the purpose of pregnancy termination. Although most centers would consider decisions about prenatal testing to be the choice of the parents, careful discussion of these issues is appropriate.
Preimplantation genetic diagnosis (PGD) may be available for families in which the disease-causing mutation has been identified. Preimplantation diagnosis has been reported in a mother with an APP mutation87, 88.
The mainstay of treatment for Alzheimer disease (AD) is necessarily supportive and each symptom is managed on an individual basis1. In general, affected individuals eventually require assisted living arrangements or care in a nursing home.
Although the exact biochemical basis of AD is not well understood, it is known that deficiencies of the brain cholinergic system and of other neurotransmitters are present. Drugs that increase cholinergic activity by inhibiting acetylcholinesterase produce a modest but useful behavioral or cognitive benefit in some affected individuals. The first such drug was tacrine; however, this agent is also hepatotoxic. Newer such drugs with similar pharmacologic action, such as Aricept® (donepezil)89-91, Exelon® (rivastigmine)92, and galantamine93-95, are not hepatotoxic.
Memantine, an NMDA receptor antagonist, has shown some effectiveness in the treatment of moderate to severe AD96-99.
Antidepressant medication may improve associated depression.
Treatment trials evaluating use of anti-inflammatory agents (NSAIDs), estrogens, nerve growth factors, ginkgo biloba, statins, BACE inhibitors, and antioxidants are under way or recently reviewed100-102.
Vitamins and other over-the-counter medications have been used in the treatment of AD103.
Some, but not all, reports suggest that affected individuals taking HMG-coenzyme A reductase inhibitors for hypercholesteralemia have a reduced incidence of dementia104-106.
Immunization of an AD mouse model with β-amyloid has attenuated the AD pathology and stimulated the search for a possible vaccination approach to the treatment of human AD107. A human trial of this approach was halted because of encephalitis in a few subjects 108-110. Alternative approaches to immunization therapy have been proposed111.
Thus far, treatment of symptomatic AD with estrogens has not proven beneficial112-113.
Genetics clinics are a source of information for individuals and families regarding the natural history, treatment, mode of inheritance, and genetic risks to other family members as well as information about available consumer-oriented resources.
Support groups have been established for individuals and families to provide information, support, and contact with other affected individuals. The Resources section may include disease-specific and/or umbrella support organizations.
Disease characteristics. Alzheimer disease (AD) is characterized by dementia that typically begins with subtle and poorly recognized failure of memory and slowly becomes more severe and, eventually, incapacitating. Other common findings include confusion, poor judgment, language disturbance, agitation, withdrawal, and hallucinations. Occasionally, seizures, Parkinsonian features, increased muscle tone, myoclonus, incontinence, and mutism occur. Death usually results from general inanition, malnutrition, and pneumonia. The typical clinical duration of the disease is eight to ten years, with a range from one to 25 years. About 25% of all AD is familial (i.e., two or more persons in a family have AD) of which about 95% is late-onset (after age 60-65 years) and 5% is early-onset (before age 65 years).
Diagnosis/testing. Establishing the diagnosis of Alzheimer disease relies upon clinical-neuropathologic assessment. Neuropathologic findings of extracellular β-amyloid plaques and intraneuronal neurofibrillary tangles remain the gold standard for diagnosis. The clinical diagnosis of AD, based on signs of slowly progressive dementia and findings of gross cerebral cortical atrophy on neuroimaging, is correct about 80%-90% of the time. The association of the APOE e4 allele with AD is significant; however, APOE genotyping is neither fully specific nor sensitive. APOE genotyping may have an adjunct role in the diagnosis of AD in symptomatic individuals and a limited role at this time in predictive testing of asymptomatic individuals. Three forms of early-onset familial AD (EOFAD) caused by mutations in one of three genes (APP, PSEN1, PSEN2) are recognized. Molecular genetic testing of the three genes is available in clinical laboratories.
Management. Treatment is supportive. Each symptom is managed on an individual basis. Assisted living arrangements or care in a nursing home is usually necessary. Drugs that increase cholinergic activity by inhibiting acetylcholinesterase produce a modest but useful behavioral or cognitive benefit in some affected individuals. Antidepressant medication may improve associated depression. An NMDA receptor antagonist is also FDA approved.
Genetic counseling. Because AD is genetically heterogeneous, genetic counseling of persons with AD and their family members must be tailored to the information available for that family. It should be pointed out that AD is common and that the overall lifetime risk for any individual of developing dementia is approximately 10%-12%. Genetic counseling for people with non-familial AD and their family members must be empiric and relatively nonspecific. First-degree relatives of a simplex case of AD (i.e., single occurrence in a family) have a cumulative lifetime risk of developing AD of about 15%-30%, which is typically reported as a 20%-25% risk. This risk is about 2.5 times that of the background risk (~27% vs 10.4%). In contrast, early-onset familial Alzheimer disease (EOFAD) with mutations in APP, PS1 or PS2 is inherited in an autosomal dominant manner.
This work was supported by funding from Veterans Affairs Research Funds and NIA/NIH grant #P50 AG 005136-22.
Published Statements and Policies Regarding Genetic Testing
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Flint Water Main Break and Road Closure Has Residents Upset [Video]
Clio road is closed between Pierson road and Home street this morning because of a water main break that has local residents very angry.
Clio road is closed between Pierson road and Home street this morning because of a water main break that has local residents very angry.
Brown water is not the norm for Flint drinking water, so when the drinking water started to change color, people started to speak up.
No matter what you do in Hip Hop, eventually somebody is going to test you.
And how you respond/react will determine how much of a success you will be.
The City of Flint released a statement yesterday detailing some major water line repairs that could cause problems for the people that rely on that water.
Despite some progress in Flint, people are still calling for Darnell Earley to leave as Emergency Manager
Cashis Da Gerberboy is back with ANOTHER banger, and this time he is rapping over Bobby Shmurda's "Hot Ni*gga".
Nearly 500 Flint residents hit the streets Sunday for the second straight year to 'Stop The Violence.'
The water issues in Flint have expanded a water boil advisory to much of the west side.
Hundreds of teens from Genesee County joined 'TeenQuest' this week to help do some much needed cleaning in Flint.
I have no idea how this happened but a Flint church air conditioning units have been stolen from their rooftop. I am extremely disappointed and hope someone will come forward with information to apprehend the people responsible.
After 3 years of group compilations Vice has FINALLY released the long awaited & anticipated project "GOD OF BLUE"!!
This mixtape credits production from Q-Tip, J-Dilla, Mr.Porter, Jon Connor, and a host of other producers.


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Ares Multi-Strategy Credit Fund, Inc. (ARMF) Ex-Dividend Date Scheduled for May 20, 2014
Ares Multi-Strategy Credit Fund, Inc. ( ARMF ) will begin trading ex-dividend on May 20, 2014. A cash dividend payment of $0.1525 per share is scheduled to be paid on May 30, 2014. Shareholders who purchased ARMF stock prior to the ex-dividend date are eligible for the cash dividend payment. This marks the 6th quarter that ARMF has paid the same dividend. At the current stock price of $22.17, the dividend yield is 8.25%.
The previous trading day's last sale of ARMF was $22.17, representing a -10.06% decrease from the 52 week high of $24.65 and a 9.7% increase over the 52 week low of $20.21.
For more information on the declaration, record and payment dates, visit the ARMF Dividend History page. Our Dividend Calendar has the full list of stocks that have an ex-dividend today.


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"We are so happy with how our wedding invitations turned out! I can't believe how much we love them. The colors are vibrant and elegant and are perfect for our Dallas rooftop wedding. I give this product 5 stars for sure and nothing less."
"We ordered this in blue, the wedding color and were thrilled! They are very simple, yet elegant and so appropriate for an outdoor blue wedding. Nice paper quality. Very happy."
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Fast Food: Creamy Shrimp and Mushroom Pasta | chaos in the kitchen......I love this recipe. It is so fast and easy yet so filling and rich. It is a company worthy dish on a weeknight time budget.
Creamy Shrimp and Mushroom Pasta. It is a company worthy dish on a weeknight time budget. - There are other shrimp pastas recipes i would make before making this one again. That being said, there wasn't anything wrong with it, just not great/memorable. -abi
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Creamy shrimp and mushroom pasta in a delicious homemade alfredo sauce. All the flavors you want: garlic, basil, crushed red pepper flakes, paprika, Parmesan and Mozzarella cheese.
CREAMY SHRIMP ENCHILADAS....I AM GOING TO MAKE THIS- never tried shrimp in my Mexican but this sounds delish!!


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Statement issued two days after stomach cancer report.
July 21, 2010 9:18 by Reuters
Reports about a deterioration in Egyptian President Hosni Mubarak's health are categorically false, his information minister said on Tuesday, two days after a U.S. newspaper said Mubarak was dying of cancer.
"The president is in good health and has been given a clean bill of health by his doctors, following his recent gallbladder surgery in Germany," Information Minister Anas El Fekky said in a statement to Reuters.
"We obviously understand the interest in this issue given Egypt's geopolitical weight, and the president's role as a force for stability in the Middle East. However, the media reports published on the president's health are based on nothing more than rumor and speculation without any factual basis whatsoever, including a recent report citing anonymous intelligence sources."
An article in The Washington Times on Sunday said Mubarak was thought by most Western intelligence agencies to be suffering from terminal cancer affecting his stomach and pancreas.
It cited a central European intelligence officer as saying the 82-year-old leader could have less than a year to live.
Rumours about Mubarak's health have rattled markets in the past because he has no designated successor. He has not picked a vice president, the post he held before taking office in 1981.
The president has returned to a regular schedule of meetings with visiting officials since having surgery at Germany's Heidelberg University Hospital in March. On Sunday he met Palestinian and Israeli leaders and other officials.
He also appeared on Egyptian television on Tuesday attending a graduation ceremony for the Egyptian police academy. Television footage showed Mubarak standing to pin medals on graduates.
The Washington Times report was the latest of several reports questioning the president's health.
The Economist published an extensive report this week on Egypt which described his health as "not good".
Egypt dismissed last week a report in Lebanon's As-Safir newspaper that Mubarak would travel abroad for treatment.
El Fekky said Mubarak was maintaining a full schedule, citing his weekend meetings and recent trips to Algeria and France. Mubarak would meet Turkish President Abdullah Gul on Wednesday and would be making a speech to mark Egypt's national day, he added.
Stockbrokers in Egypt said they had not heard any new speculation about Mubarak's health on Tuesday, but recent reports could be putting some pressure on the market.
Mubarak has not said if he will run for a sixth six-year term in a presidential election in 2011. If he does not, his politician son Gamal, 46, is seen as a likely successor. Both Mubarak and his son deny any such plan.
(Editing by Mark Trevelyan)


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September 29, 2011
This pizza is made by Foogos, who turns different foods into iconic logos. This time around, the artist behind the blog decided to pay a little tribute to the four giant turtles that set out to save their city, the Teenage Mutant Ninja Turtles.
What makes this more fitting is that the teenaged turtles were obsessed with pizza and many episodes would end with a celebratory pizza with their rat mentor.
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text: Chef Norbert welcomed us into the kitchen, starting with champagne, and several delightful appetizers. We asked Chef Norbert to surprise us!. We were treated to a nine course dinner paired with a dozen Wines. Each selected by the youth yet well versed sommelier. Of special note, each course... read more


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Available from: Mauro Angiolini
ABSTRACT The synthesis and structure-activity relationships (SAR) of p38 alpha MAP kinase inhibitors based on a pyrazolo-pyrimidine scaffold are described. These studies led to the identification of compound 2x as a potent and selective inhibitor of p38 alpha MAP kinase with excellent cellular potency toward the inhibition of TNFalpha production. Compound 2x was highly efficacious in vivo in inhibiting TNFalpha production in an acute murine model of TNFalpha production. X-ray co-crystallography of a pyrazolo-pyrimidine analog 2b bound to unphosphorylated p38 alpha is also disclosed.


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- "Only when you have soared through the morning skies on wings of flame can you understand the Hawk. Only when you have fallen screaming upon those who know they are already dead can you understand the Banshee. Only when you have annihilated those who would oppose you can you truly understand the power of the Dragon. And only one who has travelled but ultimately turned away from each of these paths can understand the Autarch."
- — Anthrillien Morningchild, Autarch of Yme-Loc
An Autarch is one of those few members of the Eldar species who have mastered many of the Eldar Paths over the centuries, including one or more facets of the Path of the Warrior. They possess a consummate understanding of the art of war and serve as the supreme commanders of an Eldar Craftworld's warhost. This Eldar Path, known as the Path of Command, is pursued by highly skilled individuals who believe martial excellence can be achieved by gaining a wider perspective of battle that allows the Eldar warhost to achieve victory in the most efficient and lethal way possible.
Autarchs do not limit themselves to the single-minded specifications required of a single Path like most Eldar. The Autarch possesses an unparalleled strategic ability which far outshines an Exarch's obsession with only a singular facet of war. This enables an Autarch to lead a warhost that operates in perfect unison, with each component of the Eldar war machine functioning in perfect synchronicity. It is not only at the aspect of command that an Autarch excels, for they are consummate warriors as well, and often spearhead assaults, fighting an enemy army's leader in personal combat or contemptuously destroying war machines with ease. Autarchs are considered integral parts of Eldar culture due to their versatility and ability to lead the Eldar on the myriad paths of life and death.
Notable Autarchs Edit
- Athanwe Illunivar - Athanwe Illunivar, also known as the Scourger of Serator Prime is fearsome in his defence of the Eldar, their ancient sites, and their artefacts, and has brought many an inquisitive Rogue Trader to ruin. In recent history, Illunivar appears to have become a major guardian of sites and locations sacred to the Eldar, in particular throughout Winterscale's Realm in the Koronus Expanse. Illunivar's complete destruction of the Rogue Trader Pietro Ironarm's flotilla in orbit around Valcetti's Salvation marked the intensifying of Eldar aggression in the region. Ironarm's flotilla had followed years of research that indicated the hidden location of an ancient xenos crash site on Salvation. Soon after the first survey craft had landed, however, a wave of Eldar assault ships attacked, destroying all of the ships in orbit. The Rogue Trader's forces still on the ground were annihilated by an overwhelming force of Aspect Warriors, led by Illunivar himself, his Swooping Hawk wings allowing him to descend upon Ironarm as he fled into the desert.
- Nyathuren Kith-menras, the Wandering Scholar - Most often alone, Nyathuren travels from planet to planet compiling a collection of all knowledge concerning ancient battles. All of her research revolves around mankind's earliest wars within the region, and she has amassed vast amounts of knowledge from that period, but she does not part with her wisdom lightly. To beg for her assistance is often more dangerous than to meet her in open combat. A Rogue Trader desperate enough to brave the Scholar's wrath, however, many seek out Kith-menras when all other options have been exhausted, but most come to regret the decision. After years of fruitless searching for any news regarding his father's lost fleet, Rogue Trader Josef Sendaarin sought the guidance of Kith-menras. Though she proved almost as elusive as the information he originally hunted, Sendaarin finally tracked down the Eldar war-sage on the battlefield world of Zayth. None know the price she exacted from this desperate scion of a once-noble family, but he returned to Port Wander a broken man and has not spoken of his father since.
- Surinthiel Mihrendelas, the Collector - From Port Wander to the Rifts of Hecaton, from the Frozen Sisters to Aubray's Anvil, Mihrendelas can be found, tracking down rumours and legends of ancient xenos artefacts. Ruthless in the extreme, no price is too high and no sacrifice too great in the pursuit of these artefacts. Several Rogue Traders have been utterly ruined through the acts of Mihrendelas, their only crime being in his way. Renowned Rogue Trader Bradfreid Craven was rendered all but destitute when he was stranded on Solace Encarmine, his ship destroyed in orbit when Mihrendelas created a new asteroid field from the planet's third moon in search of a legendary artefact. No one knows if the xenos was successful or not.
Rune Edit
The more complex an Eldar rune, the more meaning it can carry, as with the rune of the Autarch, which denotes both the aggression of the warrior and the insight of the leader in perfect union.
- Codex: Eldar Craftworlds (7th Edition) (Digital Edition), pg. 50
- Codex: Eldar (4th Edition), pg. 29
- Rogue Trader: The Koronus Bestiary (RPG), pp. 58-59


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I didn't bother buying a new SATA DVD drive when I upgraded my board and my IDE drive had no port, and the only time I've missed it has been when other people want something burned and I have to copy stuff to the laptop
Optical = Dead once DVD players = Dead and old PCs that can't boot from USB = dead
Posted 07 December 2012 - 00:52
Posted 07 December 2012 - 01:02
Mine died a few weeks back. I have a removable drive I use for my laptop that I use in it's place if I need to run a disk. I don't plan on buying a replacement.
Posted 07 December 2012 - 02:28
this might help http://winsupersite....g-web-installer
It's really stupid that Microsoft makes Win8 available for download for the consumer upgrade path but only distributes DVDs for the OEM version. I want an ISO damnit!
Posted 07 December 2012 - 02:40
this might help http://winsupersite....g-web-installer
Posted 07 December 2012 - 03:16
I guess that's why there's such things as Blu-ray players you kook up to your TV.
No service offers streaming anywhere near the quality of Blu-ray.


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Infiniti Q30 Concept: Car Tech Video
About Video
Car Tech Video: Infiniti Q30 Concept1:08 /
An Infiniti hatchback, crossover, couple mashup that might just fly.
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The next big thing in premium cars is turning out to be small. Just look at this Infiniti Q30 Concept for example. Not a dinky thing by any means, but compared to say their QX60, it looks like it just came out of a hot dryer cycle. Things like the [unk] pillars and almost too much side sculpting, that's classic Infiniti. Like Mercedes and Lexus, Infiniti is running for its life to become or stay relevant to Gen X and Gen Y and the result is something the baby boomers at Infiniti marketing call a mash-up of coupe, hatchback, and crossover. But I think it works. I would normally say you can forget about this concept car interior, but recent advances and dash technology make this one not that impossible. Not so sure about this Concept's speakers that are mounted in ceramic panels on the backs of the front seats that might stay in the design chart.


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Coach Matt Anderson is not Being Renewed as Graceville's Head Coach
Updated: 04/27/2015 - Graceville, FL---Graceville now in the market for a new hoops coach after the surprising dismissal of head coach Matt Anderson.
Updated: 04/27/2015 - Graceville, FL---Graceville now in the market for a new hoops coach after the surprising dismissal of head coach Matt Anderson.
Posted: 09/19/2013 - Now to a game set for Friday night and it may sound a bit strange to be featuring a game between a pair of oh and three teams, but that's exactly what we're doing. Holmes and Bozeman in fact our "Personal Attention Dental Care" game of the week.
Posted: 09/19/2013 - Cleveland traded the former Escambia County High School standout to Indianapolis for a 1st round draft pick in 2014.
Posted: 09/05/2013 - The Friday Night Overtime Game of the Week for episode two features 1A Port St. Joe hosting 5A Bay. Both teams are looking to do all that they can to move to 2-0.
Updated: 11/22/2013 - High School Football Scoreboard and "Friday Night Overtime" show videos.
Posted: 01/17/2012 - BRADENTON, Fla. (AP) -- Former Alabama cornerback Dre Kirkpatrick has been arrested on a marijuana possession charge.
Updated: 09/08/2010 - Video Highlights
Posted: 08/11/2010 - The Miami Heat are unveiling a partial season-ticket plan, the latest way for thousands already on the team's waiting list to have a chance to see LeBron James, Dwyane Wade and Chris Bosh this coming season.
Posted: 08/10/2010 - Minnesota Vikings wide receiver Percy Harvin remains on leave from practice, coping with migraine headaches.
Posted: 08/10/2010 - Atlanta third baseman Chipper Jones sprained his left knee fielding a ground ball in the sixth inning against the Houston Astros on Tuesday night.
Posted: 08/09/2010 - Matt Joyce homered and the Tampa Bay Rays snapped their five-game losing streak with a 6-3 win over the Detroit Tigers on Monday night.
Updated: 08/17/2009 - NBA
Updated: 08/17/2009 - NHL
Updated: 08/17/2009 - NFL
Posted: 07/10/2008 - test
Updated: 06/30/2008 - "Footy"
Updated: 07/11/2007 -
Updated: 11/04/2014 - DO NOT DELETE THIS CONTENT - DO NOT REMOVE BANNER


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water treatment Companies in Bahrain
Keyword: water treatment ×
Industry: Leather & Tanning ×
Location: Asia & Middle East ×
Location: Bahrain ×
Fluid Dynamics International Ltd
based in Maidenhead, UNITED KINGDOM
Fluid Dynamics is the original manfacturer of Catlaytic water treatment systems to stop scaling caused by hard water A truly green water treatment method proven to save energy For over 40 years we have supplied our wide range of non-chemical scale prevention products to every sector of industry,commerce and the home that suffers from hard water. Our unique products ...
Applied Aquaproducts Services
based in PAKISTAN
APPLIED AQUAPRODUCTS SERVICES (PVT) LIMITED provides industrial water treatment products and services . We are in collaboration and exclusively representing world leading water treatment manufacturer in Pakistan.• AQUATREAT, a well renowned water treatment chemical Manufacturer.• Wilhelmsen Ships Services, provide fuel oil treatment solutions and under brand name of ...
TREVI nv
based in Gentbrugge, BELGIUM
We build environmental technology!Trevi environmental solutions has a team of 90 specialised professionals at its disposal. This offers you as a client the advantage to solve all environmental problems with only one partner in all disciplines water, air, soil and energy as well.
Chempure Technologies Pvt Ltd.
based in Chennai, INDIA
Chempure Technologies Pvt Ltd. is one of the leading technical group company offering Total Water Management solution under one roof. Chempure comprises of highly qualified technocrats in the field of Water Treatment Management. Chempure has a worldwide capability in the water treatment of municipal and industrial water and wastewater. Chempure is an ISO 9001 certified ...
based in Shijiazhuang, CHINA
Supplier of Barium Sulphate, Barium Carbonate, Barium Chloride Dihydrate, Barium Nitrate, Barium Hydroxide, Barium Metaborate(Beta barium borate), barium titanate, barium oxide, Thiourea, Strontium Salt, strontium oxide, metal barium, strontium, ultra-high purity inorganic chemicals of Barium Salts, Industrial raw stuffing Materials, electrochemical,Chemical Supplier of ...
AWAS GmbH Bayern Wastewater Treatment Plants
based in Oberhaching, GERMANY
AWAS has been in research, development and manufacturing of industrial waste water treatment plants for over 30 years and owns several patents and patent rights. We manufacture: - Flotation plants (DAF) - Emulsion splitting plants - Oil-Water separators, patented AWAS Galaxie Vortex separators - Filter systems - Wash water recycling plants, wash halls - Bio reactors We ...
Kemira Water Solutions, Inc.
based in Bartow, FLORIDA (USA)
Kemira is committed to being a leading water chemistry company. Our strengths are high-level application know-how, a comprehensive range of water and wastewater treatment chemicals, and reliable customer deliveries. As a leading global provider of inorganic coagulants and organic flocculants, we offer an extensive portfolio of products that also includes biocides, ...
Sistema Azud, S.A.
based in Alcantarilla, SPAIN
Azud Group is among the world leaders in filtration, giving solutions to the optimization of the quality of water in industrial, agricultural and urban applications. SISTEMA AZUD is a group of companies made up by more than 20 firms. Sensitive to the problems of water, the main objective of AZUD is the development of technologies and products that allow the efficient use ...
EEC European Division
based in Cambridge UK, UNITED KINGDOM
Environmemtal Services including Water Treatment RO plants,Wastewater Treatment,MBBR process Wastewater Treatment MBBR-MBR process,Mini STP`s Solid Waste Treatment,DCR plants for Hazardous Waste,Plant Suppliers,Technical & Financial Proposals,sludge management, Ultra Filtration, Operator Training,Operation Manuals.
Combined Environmental Technologies Ltd (Ireland)
based in Skerries, IRELAND
Combined Environmental Technologies is a wastewater treatment technologies company providing Compact & Modular wastewater treatment solutions to the Municipal, Industrial, Chemical, Pharmaceutical, Petrochemical and Landfill industry. Combined has developed an innovative new process called "Pro-Bio Advanced Treatment" for the treatment of Landfill Leachate and other ...
Related Terms for water treatment
Need help finding the right suppliers?
Let the XPRTs do the work for you


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Nabi Hits Final Milestone in GSK Staph DealApril 27, 2011 7:36 am | News | Comments
Nabi Biopharmaceuticals has completed the Phase 1 trial for two of the PentaStaph antigens. Completion of this trial was the final milestone associated with the sale of the PentaStaph vaccine to GlaxoSmithKline.
Protein Inhibitor May Topically Treat HPVApril 27, 2011 7:30 am | News | Comments
Thanks to new research, patients infected with cancer-causing HPV may someday have an alternative to surgical and harsh chemical treatments. Scientists report on the development of a protein-based inhibitor that could provide a topical treatment for HPV.
Expert Helps Pinpoint Best Treatment for GTNApril 27, 2011 7:28 am | News | Comments
A clinical trial has sifted out the most effective single-drug chemotherapy regimen for quick-growing but highly curable cancers that arise from the placentas of pregnant women.
Enrollment Wraps Up in Phase 3 Pain TrialApril 27, 2011 7:20 am | News | Comments
QRxPharma Limited announced it has completed patient enrolment for Study 022, a Phase 3 trial comparing the tolerability and safety profile of MoxDuo IR to equi-analgesic doses of either morphine or oxycodone alone.
FDA: Hepatitis Drug Is Highly EffectiveApril 27, 2011 7:18 am | by Matthew Perrone | News | Comments
Federal health officials said a highly anticipated hepatitis C drug from Vertex Pharmaceuticals successfully treats the majority of patients with the virus in less time than older medicines that have been used for 20 years.
Push for More Drugs for Deadly, Rare DiseasesApril 27, 2011 7:16 am | by Lauran Neergaard | News | Comments
Every other week, 7-year-old twins Addison and Cassidy Hempel have an experimental medicine injected into their spines in hopes of battling a rare, fatal disease. And it's their mom who made that possible.
Hospira Income Up 6% in First QuarterApril 27, 2011 7:12 am | News | Comments
Drug and medical device maker Hospira Inc. said its net income rose 6 percent in the first quarter on strong sales of new products, including generic versions of the cancer drugs Gemzar and Taxotere.
Medtronic, Eli Lilly Collaborate on Parkinson'sApril 27, 2011 7:09 am | News | Comments
Medical device maker Medtronic and drugmaker Eli Lilly said they will collaborate on an implantable drug delivery system to treat Parkinson's disease, the debilitating brain disorder that causes tremors and movement problems.
What to Expect from BMSApril 27, 2011 7:08 am | News | Comments
Drugmaker Bristol-Myers Squibb Co., which recently got approval of an important new skin cancer drug but is facing a sharp revenue drop next year, will report first-quarter results before the stock market opens Thursday.
Regeneron Cancer Drug Meets Study GoalsApril 27, 2011 7:05 am | News | Comments
Regeneron Pharmaceuticals Inc. and partner Sanofi-Aventis' potential cancer drug met key goals in a late-stage study focusing on colon cancer patients.
Merck Approves $5B in Stock BuybacksApril 27, 2011 7:02 am | News | Comments
Merck & Co. Inc. said its board of directors approved the buyback of up to $5 billion in common stock for the drug developer's treasury. Overall, the company is now authorized to buy back up to $6.4 billion in common stock.
J & J Buying Synthes for $21.3BApril 27, 2011 6:59 am | by Frank Jordans | News | Comments
Health products giant Johnson & Johnson said it will buy U.S.-Swiss medical device maker Synthes Inc. for $21.3 billion, greatly increasing its share of the market for surgical trauma equipment and orthopedic implants.
API ToolkitApril 26, 2011 8:31 am | Product Releases | Comments
Sage-N Research, Inc. announced a new API toolkit for developers of proteomics data analysis software. The toolkit will enable software developers to add the power and sensitivity of SORCERER analyses to their existing software packages.
Syringe PumpsApril 26, 2011 8:29 am | Drug Discovery & Development | Product Releases | Comments
Harvard Apparatus has introduced a new line of OEM Syringe Pumps designed for specialized solutions for a variety of fluid handling applications to meet fluidics research requirements.
KemPharm Working With MonoSol on ADHD TreatmentApril 26, 2011 8:22 am | News | Comments
KemPharm, Inc. announced that KP106 will be formulated and developed in an oral film dosage form pursuant to an exclusive collaboration agreement with MonoSol Rx relating to the development, commercialization and manufacture of KP106.


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London area of SW8 guide
What to do and where to stay in London's SW8 neighbourhood
The SW8 postcode takes in the area of South Lambeth and Nine Elms, as well as parts of Vauxhall and Battersea. Largely a residential area, SW8 is centred on the New Covent Market, a large wholesale fruit, vegetables and flowers market. The name Lambeth means "landing place for lambs" in Old English and refers to a harbour on the Thames where lambs were either shipped from or to, back as late as the 11th century. There's a large Portuguese community in South Lambeth and many bars and restaurants with a strong connection to both Portugal and Madeira are located on the South Lambeth Road. The derelict Battersea Power Station, with its iconic four towers, is also found in SW8. Vauxhall is renowned for its gay nightlife scene, with the famous pub the Royal Vauxhall Tavern and nightclub Fire particularly popular.
See our recommended nearby SW8 Hotels, Sights and Attractions, Shopping, Restaurants, Pubs, Nightlife, Leisure, and Meeting Venues.
SW8 Hotels
London > Apartment > Apartment
Dolphin Square, SW1V
Dolphin House is a wonderfully quiet spot.The tranquillity is all the more surprising given its close proximity to Victoria, making it convenient for Westminster and Tate ... More
London > Hotels > Budget Chain Hotel
106 - 110 Belgrave Rd, SW1V
Victoria is one of the great transport hubs of London, a bustling area that offers great connections to the rest of the capital and the South ... More
London > Hotels > Budget Chain Hotel
85-89 Belgrave Road Victoria, SW1V
An elegant Victorian building on the outside, this has been carefully and attractively converted inside to include modern essentials like quick Internet access. Near the very ... More
SW8 Sights and Attractions
London > Attractions > Attractions for Kids
Grosvenor Waterside, 30 Gatliff Road, SW8, London SW1W
Purple Dragon is a dream playground, kindergarten, day nursery and private members' for kids. Relocated from its original location in Battersea, the exclusive club occupies ... More
London > Attractions > Art Galleries
Millbank, SW8, London SW1P
Overlooking the River Thames, Tate Britain was originally founded through the philanthropy of the sugar magnate Sir Henry Tate. The Tate legacy now encompasses three other ... More
London > Attractions > Art Galleries
50 Moreton Street, SW8, London SW1V
... More
SW8 Shopping
London > Shopping > House and Garden
Brunswick House, 30 Wandsworth Road, Vauxhall, SW8, London SW8
Architectural salvage produces the most gloriously mismatched collection of pieces, all housed in this disused church. Stock changes constantly; look for anything from stuffed animals to ... More
London > Shopping > House and Garden
42 Moreton Street, SW8, London SW1V
Antique Textiles... More
SW8 Restaurants
London > Restaurants > Spanish restaurants
34 Lupus Street, Pimlico, SW8, London SW1V
Spanish cuisine. ... More
London > Restaurants > Italian restaurants
46 Moreton Street, SW8, London SW1V
Pizza Express has become something of a London institution. Serving consistently excellent Italian pizzas quickly in pleasant unfussy surroundings, this is always a convenient and acceptable ... More
London > Restaurants > British restaurants
Millbank, SW8, London SW1P
The Rex Whistler Restaurant at Tate Britain gets its name from the specially commissioned Rex Whistler mural, 'The Expedition in Pursuit of Rare Meats', which provides ... More
SW8 Pubs
SW8 Nightlife
SW8 Leisure
London > Leisure > Activities
136 Grosvenor Road, SW8, London SW1V
... More
SW8 Meeting Venues
London > Business > Venue Hire
Millbank, SW8, London SW1P
Conference facilities can accomodate up to 1550 people.... More
London > Business > Venue Hire
136 Grosvenor Road, SW8, London SW1V
... More
London > Business > Venue Hire
Riverside Walk, Nine Elms Lane, SW8, London SW8
... More
London Hotels
From cheap budget places to stay to luxury 5 star suites see our special offers for hotels, including DoubleTree by Hilton London Hyde Park from 69% off.


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August 28, 2008 Just when you figured that the incremental development of the Universal Japanese Motorcycle was all you'd ever see comes news that Kawasaki is about to release a bombshell on the motorcycling world with the release of a radically different engine. Spanish Motorcycle Magazine SoloMoto has details of the new motor revealed in an exclusive interview with a Kawasaki executive and plans to print the details in its September 16 issue. Most significantly, the preview interview, (here in Spanish), indicates that it will feature similar technologies to those employed in the KTM-owned Husaberg 450 we wrote about earlier this year. The radical Husaberg engine has been reconfigured to put the crankshaft near the motorcycle's center-of-mass and results in a significant improvement in handling. Kawasaki's patents predate the Husaberg design by several years and the technologies will be applied to motors with different numbers of cylinders and extending to KHI's four-wheelers as well.
Kawasaki preparing revolutionary new engine
About the Author
Mike grew up thinking he would become a mathematician, accidentally started motorcycle racing, got a job writing road tests for a motorcycle magazine while at university, and became a writer. As a travelling photojournalist during his early career, his work was published in a dozen languages across 20+ countries. He went on to edit or manage over 50 print publications, with target audiences ranging from pensioners to plumbers, many different sports, many car and motorcycle magazines, with many more in the fields of communication - narrow subject magazines on topics such as advertising, marketing, visual communications, design, presentation and direct marketing. Then came the internet and Mike managed internet projects for Australia's largest multimedia company, Telstra.com.au (Australia's largest Telco), Seek.com.au (Australia's largest employment site), top100.com.au, hitwise.com, and a dozen other internet start-ups before founding Gizmag in 2002. Now he writes and thinks.All articles by Mike Hanlon
Related Articles


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During Arish's first year, I had to plan when to go to the bathroom, how fast I could run, and how quick I could finish my business there. 87 more words
Tags » Bathroom Break
King of the World
MBQ | Weirdest Thing You've Ever Done While Driving?
A new survey by The Chicago Tribune found that 3% of us have gone to the bathroom while driving a car. (Something tells me those people aren't in the car pool anymore, but…) 90 more words
Patrick Sondheimer - Black box reveals Captain was encouraged by Andreas Lubitz to take bathroom break ... later shouted 'Open the goddamn door!' before Germanwings 9525 crashed into mountainside
- Lubitz tells captain Patrick Sondheimer he can go to the toilet at any time
- Tells the captain he will take over controls and later says 'you can go now' 89 more words
A Fact Of Daily Life
I came across this picture and laughed to myself at how "fact of life" it is…
This usually happens to me sometime during the middle of the night when I am pretty much sleep walking on my way to the bathroom…nearly fall over trying to get my pants down…and of course end up with a tush full of water after not realizing that my husband has left the toilet seat up… 14 more words
Student Survival: 6 Ways To Stay Awake In Class
It can be one of the hardest things in the world for a student to stay awake in class, particularly if you were on the beer the night before. 442 more words
Flying By the Seat of Your Porcelain Pants
Next time you do a fly by–and for all those who don't know a fly by is when you scope out a bathroom to see if it's free before doing the deed–check out some new entertainment: 372 more words


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Damascus Nannies
1 nannies near you. Average nanny rate in Damascus: $12.00/hr. Share with friends.
Damascus, VA
I enjoy going to the park, playing board games, and being out doors. Your child will not be bored. I adore getting to see children experience the wonder of being outside and seeing new things for the ...
2 yrs of exp.
19 years old
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|Playful Puzzles featuring Artwork of Pop Artist Romeo Britto!
Quite possibly the world's best artwork for puzzles! Beyond the fabulous colors and stunning beauty of this iconic pop art are qualities of a truly great puzzle. Color variances, playful patterns and bold, black lines are the ideal reference points for a fun and challenging puzzle. Premium print on quality blue board.
Playful Jigsaw Puzzle 19 x 14 inches • 100 color pieces!
About Romero Britto:
A modern day pop culture icon, Romero Britto is one of the premiere artists of our time. As the youngest and most successful Pop Artist of this generation, Britto creates contemporary masterpieces that evoke a spirit of hope and convey a sense of warmth. His works are a reflection of what words fail to express about the joys of life, and his pieces will continue to withstand the test of time because there is a Britto for everyone.
P'kolino products meet or exceed US, EU, and Canadian safety standards. Made in China.
|By Rail Fabric Wall Decal
|Polka Dot Tree Fabric Wall Decal
|Stokke Crusi Sibling Seat