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Gary D'Amato offers news and insights on Wisconsin golf, new technology, courses and instruction
Survey ranks top courses in Wisconsin
All four golf courses owned by the Kohler Co. rank among the top six public-access courses in the state, according to a survey of 25 Wisconsin sports media members and golf industry experts conducted by www.GolfWisconsin.com.
The survey asked respondents to rate courses based solely on the quality of the design and to disregard factors such as amenities and quality of service. (Full disclosure: I participated in the survey.)
It came as no surprise that Whistling Straits, site of the 2004 PGA Championship, was ranked No. 1. The River Course at Blackwolf Run was No. 2 and the other Kohler-owned courses, the Meadow Valleys and Straits, were ranked Nos. 4 and 6, respectively. The Bull at Pinehurst Farms in Sheboygan Falls came in at No. 3 and Erin Hills in the Town of Erin was No. 5.
Perhaps the biggest surprise was that Wild Rock in Wisconsin Dells, a course that isn't even scheduled to open until May 1, was No. 17. Wild Rock held a sneak-preview media day last fall, which undoubtedly helped.
The survey was conducted by Brian Weis, owner of GolfWisconsin.com, and Glen Turk, a contributing writer / editor at Midwest Golfing Magazine.
Here are the top 25 courses in the state, according to the survey:
1. Whistling Straits; 2. Blackwolf Run River; 3. The Bull at Pinehurst Farms; 4. Blackwolf Run Meadow Valleys; 5. Erin Hills; 6. Irish Course at Whistling Straits; 7. The Bog; 8. University Ridge; 9. Lawsonia (Links); 10. Brown Deer Park; 11. SentryWorld; 12. Geneva National (Player); 13. Grand Geneva Resort (Brute); 14. Lawsonia (Woodlands); 15. Geneva National (Palmer); 16. Trappers Turn; 17. Wild Rock; 18. Washington County; 19. Brown County; 20. Mascoutin; 21. Lake Arrowhead (Pines); 22. Big Fish; 23. Troy Burne; 24. Northern Bay; 25. Lake Arrowhead (Lakes).
So, readers, what do you think of the list?
Comments »
Read and share your thoughts on this story.


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Watch the buzz in Hawkins Field from the minute the gates opened to the final out of the Commodores' 7-1 win over Georgia Tech in the Nashville Regional Championship Monday.
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Houston Rockets point guard Jeremy Lin suffered a nasty cut when he banged heads with Milwaukee Bucks center Larry Sanders during Friday night's NBA game at BMO Harris Bradley Center. Early in the third quarter, Lin and Sanders were chasing down a loose ball on the Rockets defensive end of the court. Lin got to the ball first but the collision with Sanders opened up a cut on the left side of his head. Lin left the game to receive five stitches, but proved his toughness by returning to the bench late in the third quarter and starting the fourth quarter. Lin finished the game with 8 points and 7 assists in a 115-101 Rockets victory. Video via. Visit us at holdoutsports.com and follow us on Twitter @HoldoutSports.
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Catalog Search
Category: Strategy Games
Cop & Killer A killer is in the city, and his victim is unsuspecting. The cop is already on the trail: Who has an alibi and who has something to hide? Funagain Games does not stock this edition of this title, usually because it's out of print.
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Bus Stop Fanart version by NicoleDaneyWatch
©2012-2015 NicoleDaney
Bus Stop fake screenshot with designs of the main 4 based on their despiction on Fanart ♥ Looks like Eric and Kyle are arguing again...
Hope you like it South Parkers! ♥
Everyone (c) Matt and Trey
Art (c) Me, ~NicoleDaney ♥
Hope you like it South Parkers! ♥
Everyone (c) Matt and Trey
Art (c) Me, ~NicoleDaney ♥
KYAAAA I just love little poodle Kyle! >3<
i love how you drew kyle and stan, they look super cute with their hair sticking out!!!
Wow! I bet they're going to look like this by the time they're in 5th grade
Haha, I don't know! They're not different or taller, I just changed their clothes up a little bit, you know? c:
Gotta admit, they look way better than they do in the show
Thanks! Although the models I made are the same, just kinda made their hats look like how it would actually look in real life. Just what kid uses a hat until it touches their eyes? That's really umconfortable.
They look so much better like this!
I really like your designs of the characters! I headcanon Eric wears a scarf, too!
Well, in my designs everyone's got a scarf except Kenny. Haha.
Thank you! I'm so glad you like them ♥
Thank you! I'm so glad you like them ♥
Absolutely WONDERFUL!
post season 5
Im so glad im not the only one who likes drawing kyle with a scarf!!
{{I wish they looked like this in the show~=w= The fluff and the hair looks WAY TOO cute!! }}
Heheh, I would give anything for my designs to be the officials~
Thank you ♥
Good Job!
Ha ha, this is great And so true ^^ Great job !
Why is it true though? xD
Thanks, glad you like it! ♥
Thanks, glad you like it! ♥
Sexy? Heheh, thanks ♥
Yep, sexy!
Thanks but why? I'm curious
Hehehe, thats for me to know, sweetie.
Aww c'mon,tell me, please?


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Out of Stock
Our dreams have been answered! A poster-sized calendar with a bubble to pop every day! It really puts our love of popping sheets of plastic bubbles to a useful purpose: counting down the days until I leave my crummy boyfriend. The 2016 Bubble Calendar is appropriate for any design (and fun) conscious home or office. Just make sure that jealous friends and co-workers don't pop your bubble wrap! It's also perfect gift for that obsessive person in your life as long as they don't pop the whole year the first day! The calendar is fully functional with days of the week and all major U.S. holidays marked and weekends in bold for easy reference. Yes, weekends are in bold because we're all working for the weekend! Measures 48" tall x 18" wide. Printed on heavy 100lb glossy cover stock. Handmade in Brooklyn, USA.
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Oracle Technical Architect Jobs in London
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Lawrence Harvey Enterprise
As such the opportunity for this Oracle Technical Architect involves significant opportunity to progress through the business and take on increasing responsibility. Requirements - - Several years experience with the Oracle technology stack, including recent Technical architecture exposure, preferably covering Integration and Infrastructure architecture. - Demonstrable background in taking the lead in technical...
Salary: £65000.00 - £85000.00 per annum + Benefits + BonusPosted: Yesterday


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New Hire
4C Insights Hires Aaron Goldman as CMOJune 04, 2015
Goldman, a past DMN 40 Under 40 award winner, is a well-known advertising innovator.
News Byte: Coldwater Creek Hires New SVP, CMOAugust 15, 2013
Deborah Cavanagh seeks to "revitalize" the women's accessories and apparel retailer.
Rosetta Hires Joe Lozito as CTOJuly 09, 2013
Joe Lozito aims to create a unified vision for Rosetta's international and domestic teams.
Businesses fill their marketing plates with new CMOsNovember 23, 2012
Whether focused on enhancing global brand development or overseeing digital, here are four newly appointed CMOs who are anything but left-overs.
Did an office products clash produce a CMO?November 06, 2012
OfficeMax presses ahead by appointing a new chief marketing and strategy officer, even as rumors swirl about a merger with Office Depot.
Campbell feeds global marketing appetite with new CMOOctober 31, 2012
The CPG company continues to expand its marketing efforts with a new CMO position
Rio SEO appoints its first-ever operating head since Covario separationSeptember 05, 2012
Covario, a provider of search marketing solutions and services, has hired Christopher Reid in the newly created position of SVP and operating head of Rio SEO, Covario's software unit.
Mitel hires CMO to guide changing go-to-market strategyAugust 27, 2012
Mitel, a provider of unified communications (UC) and contact center technologies, announced Aug. 27 that Martyn Etherington had been named company CMO.
Aflac restructures marketing, hires Experian exec in new roleAugust 09, 2012
In the process of restructuring its marketing organization, insurance provider Aflac announced Aug. 9 that Experian's John Harmeling has assumed the newly-created role of SVP of worksite marketing, effective two weeks ago.
The Vitamin Shoppe strengthens e-commerce investment with new hireAugust 06, 2012
The Vitamin Shoppe, a health supplement provider, has named Stephen Bontempo to the newly-created position VP of e-commerce.
Qualcomm names new CMOAugust 06, 2012
Intel veteran Anand Chandrasekher has been named CMO of mobile technology company Qualcomm. Chandrasekher replaces previous CMO Jeff Jacobs, who left the company to pursue other opportunities.
DMW Direct "upgrades" with new director of digital marketingJuly 30, 2012
Direct response advertising agency DMW Direct has appointed Greg Marta as its director of digital marketing in a move to "upgrade" the company's digital proposition and service offerings.
Yankee Candle hires new president of direct and CMOJuly 23, 2012
Yankee Candle Inc. has appointed Brad Wolansky to the newly created roles of president of direct and CMO.
Marketo appoints Greg Higham to new CIO positionJuly 19, 2012
Marketing software company, Marketo appointed Greg Higham as the company's first CIO—a position created due to Marketo's global expansion.
PulsePoint appoints Sloan Gaon CEOJuly 18, 2012
PulsePoint, a global digital technology company, appointed Sloan Gaon as CEO, effective as of July 9, 2012.
ClearSaleing names Ari Osur general managerJune 28, 2012
Ari Osur has been hired as general manager of ClearSaleing, an advertising analytics and attribution platform and subsidiary of eBay company GSI Commerce.
Euro RSCG Tonic names new strategic planning headJune 19, 2012
Euro RSCG, an agency specializing in integrated consumer health and wellness, has named Katie Rogin as its managing director of strategic planning.
Bob Zurek named Epsilon's SVP of productsMay 22, 2012
Bob Zurek has been named Epsilon's SVP of products, said Epsilon president Andy Frawley, to whom Zurek will report.
Ogilvy & Mather New York names chief creativeMarch 08, 2012
Ogilvy & Mather (O&M) New York has named Calle Sjoenell chief creative officer, said Toni Lee, director of PR at Ogilvy & Mather Worldwide. Sjoenell will report to O&M North American chief creative officer Steve Simpson.
Marketsmith promotes insider to GM and EVPMarch 07, 2012
Carina Pologruto has been promoted to GM and EVP of client services at direct marketing agency Marketsmith, said Monica Smith, CEO of Marketsmith. Smith, who previously served as president and CEO, will relinquish her role as president and cede day-to-day client services operations to Pologruto.
Razorfish CEO to oversee four additional agenciesDecember 05, 2011
Bob Lord, global CEO of Razorfish, has added VivaKi network agencies Big Fuel, Denuo, Digitas and Phonevalley to his responsibilities, he said on Dec. 5. He replaces former Digitas CEO Laura Lang, who previously oversaw these assets prior to being named CEO of Time Inc.
Digitas CEO to leave for Time Inc.December 01, 2011
Digitas CEO Laura Lang has been named CEO of publishing company Time Inc. Lang will replace Jack Griffin who was fired in February, six months after being named to the position. She will report directly to Time Warner Inc. CEO Jeff Bewkes.
Drakoulias promoted to Draftfcb global chief of staffNovember 15, 2011
Peter Drakoulias has been promoted to the newly-created position of global chief of staff at Draftfcb effective immediately, he told Direct Marketing News. He will report to Draftfcb president and CEO Laurence Boschetto and he will partner with George Kane, EVP and worldwide financial director, to oversee the agency's global M&A activity.
Draftfcb hires Nielsen to lead Beiersdorf accountOctober 06, 2011
Draftfcb has named Rob Nielsen global executive creative director for the agency's Beiersdorf AG account. He will join Draftfcb on Oct. 10 and report directly to Jonathan Harries, the agency's vice chairman and global chief creative officer.
Who's Who and What's What at DMA 2011October 04, 2011
With so much networking and knowledge-sharing happening among this year's Direct Marketing Association: 2011 Conference & Exhibition's attendees, it's easy to overlook the announcement of new innovations. In the past several days, the following product launches and employee hires were revealed:
Cabela's names Williams CMOSeptember 28, 2011
Cabela's Inc. named Scott Williams its EVP, chief marketing and e-commerce officer, the outdoors product retailer said in a statement. Williams will report to Cabela's CEO Tommy Millner.
Fewer direct, digital marketers plan to increase staff in Q4: Bernhart AssociatesSeptember 26, 2011
The number of direct and digital marketers planning to add staff decreased for the third consecutive quarter, according to an employment report from recruitment firm Bernhart Associates Executive Search released Sept. 25.
Lanctot named Razorfish chief media officerSeptember 15, 2011
Publicis Groupe-owned digital agency Razorfish has named Jeff Lanctot chief media officer. He will join the company Oct. 5, reporting to global CEO Bob Lord.
Miller named SolutionSet MediaWhiz CMOSeptember 14, 2011
The SolutionSet MediaWhiz Partnership has named Michael Miller CMO. He will manage the agency's marketing and growth initiatives in the newly created position, reporting to Zain Raj, the firm's president and CEO.
Consuegra out as Forbes CMOSeptember 09, 2011
Forbes Media will replace Jorge Consuegra as CMO with Jack Laschever, a former group publisher at the company, Direct Marketing News learned September 9. Consuegra was named Forbes' first CMO in January.
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THRIVER - Day 1 Part 5 - Today's Christian Videos
Embed realigion 2271 views 2008-03-17T00:00:00 INNERSTATE180.COM - The popular reality TV series Survivor puts ordinary people in a survival challenge that focuses on exploiting others to win a prize. We believe that the purpose of our lives isn't survival, but to thrive in Christ. Watch this intro video that sets the stage for the THRIVER series.
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June 27, 2015
Exploring the Heritage Vineyards of Sonoma County: A Trip Well Taken Cohn Vineyard Bacigalupi Paris Tasting Block Rochioli Vineyards & Winery West Block Lynmar Estate Quail Hill Vineyard Dehlinger Winery Old Vines Pellegrini Wine Co. Olivet Lane Vineyard Hanzell Vineyards The Ambassador's 1953 Vineyard Patz & Hall Sonoma House Visit & Tasting with James Hall Hyde Vineyard Saturday Night Dinner Bacchanal Pinot Briefs A Reader's Letter Brightens My Day
Vineyard: Byington Estate
Articles mentioning wines produced from this vineyard
Wineries sourcing from this vineyard
Reviewed wines produced from this vineyard
2012 Ser Santa Cruz Mountains Pinot Noir
14.2% alc., 180 cases, $33. "Ser" translates to "To be; expressing identity or origin" in Spanish. Ser is a small boutique wine company based in Santa Cruz, California featuring wines vinified by owner and winemaker Nicole Walsh. 40% Lester Family Vineyard, 30% Lilo Vineyard, and 30% Byington Vineyard. Vineyards were fermented separately. 5 to 6-day cold soak, indigenous yeast fermentation, gently pressed into 10% new and 90% neutral French oak barrels. Aged 14 months in barrel. · Moderately light garnet color in the glass. This is a savory wine with more interest than just fruit. The nose offers aromas of cherry, sous-bois, iron, tomato, herbs and wood. Light and elegant in style, but with a noticeable midpalate attack of red cherry, cranberry and red raspberry fruits. Slightly confected with a prominent savory herb undertone. Slightly plush on the palate with suave tannins, juicy acidity, and some finishing length. Very forward and easy to like and a perfect foil for grilled salmon. Score: 89. Reviewed October 21, 2014 WINERY » ARTICLE »
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The 2nd witness of Revelation 11 is the prince of Israel
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When people accept Jesus as Lord and Savior, repent, and turn from sin they become the temple of God. God had 2 physical temples that were destroyed, but because of what Jesus did we are now spiritual temples that can't be destroyed. The mission of the two witnesses is to build the temple of God. How do you build the spiritual temple of God? You tell people the good news(gospel) of what Jesus did so that they may be saved and become a temple, and all the temples combined are one temple for all are one in Jesus Christ. If you read the book of haagai and zechariah it shows joshua and zerubbabel building the temple. These two books show the two witnesses in the end, those books show the physical rebuilding after the destruction of Israel but the two end times witnesses rebuild the spiritual temple, same story just spiritual instead of physical. So if someone is promoting themselves and calling people idiots, stupid and such they are not building the temple of God they are tearing it down. Look at yourself and see are you building the temple of God by telling others of Jesus or are you tearing down the temple by promoting yourself and not even mentioning Jesus? Accept Jesus as savior today, become a temple, and encourage others to be part of the kingdom.
2nd corinthians 6:16:
And what agreement hath
the temple of God
with idols? for
ye are the temple of the living God
; as God hath said, I will dwell in them, and walk in them; and I will be their God, and they shall be my people.
The beast and the false prophet build the physical temple but the two witnesses build the spiritual temple(tell people about Jesus is building the temple). Those who accept Jesus as Lord and Savior, repent, and turn from sin are the temple of God
If then you were raised with Christ, seek those things which are above, where Christ is, sitting at the right hand of God. Set your mind on things above, not on things on the earth. For you died, and your life is hidden with Christ in God. When Christ who is our life appears, then you also will appear with Him in glory.
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Man finds dollar wife signed years after her death
Remember when the schools started having students rat their parents out? Video Reveals Jade Helm Plans For Children
IRS Makes It Illegal For Small Businesses to Help Employees Pay Healthcare Premiums
After children are damaged by vaccines, parents are intimidated and bullied into silence
Wilderness Corridors: Agenda 21 Under A New Name
Big Brother "Pay-by-the-Mile" Track and Tax Driving Scheme Being Rolled Out Now!
Where's Your Place in Jade Helm?
Aluminum, Barium and Strontium: the New Manhattan Project chemtrail sprays
According to a YT channel , every time you drink a glass of water, you are drinking molecules that have previously been urinated from a dinosaur.
More Bans/Censorships In Oregon: Orwellian College Professor Places Ban On Opinions In Class
Researchers in Russia have said that they have found an artifact object that appears to be a 250 million year old microchip.
A recent study has found that the smell of fish can improve critical thinking by arousing suspicion.
The Woolly Mammouth is now many steps closer to becoming a living, breathing reality.
A leaked Whitehall paper suggests that plans to scrap part of the UK's main sickness benefit are being considered
Services such as Paypal, and Itunes have been suspended from processing payments in Greece under the country's new capital control laws.
British Rockstar Shaun Ryder has admitted that he witnessed a UFO hovering outside of his bedroom window
Pharmaceutical giant Johnson and Johnson have developed a new vaccine to protect against AIDS, and have begun testing it on humans
Another Alternative Doctor Found Dead, Police Investigation Underway
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Liberals passed a bill to change this fish's name because it is "hurtful" and "offensive"
Growing Own Food Greek Man's Secret Weapon Against Economic Meltdown
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Class action over "Good til Cancelled" program
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Social media monitoring guide from DHS
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The Skew-Normal and Related Families
Institute of Mathematical Statistics Monographs (Book #3)Interest in the skew-normal and related families of distributions has grown enormously over recent years, as theory has advanced, challenges of data have grown, and computational tools have made substantial progress. This comprehensive treatment, blending theory and practice, will be the standard resource for statisticians and applied researchers. Assuming only basic knowledge of (non-measure
Data Analysis and Data Mining: An IntroductionAn introduction to statistical data mining, Data Analysis and Data Mining is both textbook and professional resource. Assuming only a basic knowledge of statistical reasoning, it presents core concepts in data mining and exploratory statistical models to students and professional statisticians-both those working in communications and those working in a technological or scientific capacity-who have
Methods of Multivariate Analysis
Wiley Series in Probability and Statistics (Book #709)Praise for the Second Edition "This book is a systematic, well-written, well-organized text on multivariate analysis packed with intuition and insight . . . There is much practical wisdom in this book that is hard to find elsewhere." —IIE Transactions Filled with new and timely content, Methods of Multivariate Analysis, Third Edition provides examples and exercises based on more than sixty real
Multivariate Analysis for the Biobehavioral and Social SciencesAn insightful guide to understanding and visualizing multivariate statistics using SAS®, STATA®, and SPSS® Multivariate Analysis for the Biobehavioral and Social Sciences: A Graphical Approach outlines the essential multivariate methods for understanding data in the social and biobehavioral sciences. Using real-world data and the latest software applications, the book addresses the topic in a
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Sears Canada Head to Run Barnes & Noble
Ron Boire has been named the next CEO of Barnes & Noble, Inc., beginning September 8.
Children's Job Moves: June 2015
New job announcements in children's publishing for June 2015.
No, Bill O'Reilly, 'Killing Patton' Was Not the Bestselling Book of 2014
A response to inaccurate statements made by O'Reilly about 'Publishers Weekly' and his book sales history.
Campbell, Guenther Named Board Directors at B&N
Barnes & Noble has appointed Ann-Marie Campbell, president, Southern division, The Home Depot; and Paul B. Guenther, former president of PaineWebber Group, Inc., as new independent board directors.
Augenbraum Stepping Down at National Book Foundation
The National Book Foundation has announced that Harold Augenbraum, its longtime executive director, will be stepping down in March.
Authors on the Air June 15, 2015: Kate Atkinson
Kate Atkinson, author of 'A God in Ruins' (Little, Brown; 9780316176538) will appear on NPR's 'Morning Edition' on Tuesday, May 16.
Glenn Named Publisher at Humanix Books
Mary Glenn, former associate publisher at McGraw-Hill Professional, has been named publisher of Humanix Books.
Cochrane Named Publisher of PRH Canada Amid Restructuring
All of the company's adult imprints will now be published under a new division, Penguin Random House Canada Publishing Group, while the company's children's divisions have been united under Tara Walker.
Levy Named to NBF's Board
Reynold Levy, former head of Lincoln Center for the Performing Arts, has been elected to the board of the National Book Foundation.
Authors on the Air June 5, 2015: Jesse Goolsby
Jesse Goolsby, author of 'I'd Walk with My Friends If I Could Find Them' (HMH, 9780544380981), will appear on NPR's 'Weekend All Things Considered' on Sunday, June 7.
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Win 'The Beatles in Mono' Vinyl Box Set
On Sept. 9, the Beatles will release a 14-LP box set containing their mono mixes.
On Sept. 9, the Beatles will release a 14-LP box set containing their mono mixes.
Just as we had "American Bandstand" and other music and dance shows during the 1960s, British teen viewers watched a TV program called, "Ready, Steady, Go!". The show aired on Friday nights with the slogan, "The weekend starts here". And in 1964, "The Beatles" made a memorable appearance.
On this day in 1965, "The Beatles" played before their largest live audience ever in that famous concert at Shea Stadium (former home of the New York Mets) in New York City.
During the height of Beatlemania, when "The Beatles" took to the stage for a live concert, it was pandemonium. On this day in 1966, the lads performed a live concert at Cleveland Stadium in Ohio.
Mass murderer Charles Manson thought he heard secret messages in the Beatles' 'White Album.'
We look at seven bands who were wrongly labeled - or more foolishly, called themselves - the next Beatles.
A stroll across the street near the Beatles' recording studio on Aug. 8, 1969 turned into the iconic cover for 'Abbey Road.'
Wayne Coyne reveals the artists who will appear on the Flaming Lips' remake of 'Sgt. Pepper's Lonely Hearts Club Band' by the Beatles.
If you ever wanted to know the definition of irony, I would have to say this story pretty much sums it up.
2014 has been filled with anniversaries for "The Beatles", and on this day in 1964, "A Hard Day's Night" album was released in England. And that means the the signle and iconic film of the same name are 50 years old as well.
If you're a Beatles fan, there are some things that you absolutely need in your collection. Here are some can't-miss items to check out:
As you probably know, Ringo Starr and his All Starr Band is appearing live in concert at Turning Stone Resort & Casino Event Center, Wednesday, June 25th. You know the songs that Ringo sang as a member of "The Beatles", but what about his solo hits?


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On Using Survey and Administrative Disability Data: A Canadian Perspective Aron Spector, Senior Researcher, Strategic Policy Research Directorate (SPRD) Human Resources and Social Development Canada (HRSDC) For: The ISDS State of the Art Conference: Developing Improved Disability Data Washington, D.C. July 11-12, 2006 Background: The HRSDC Mandate Foster participation in work, learning, communities and society Improve economic security Support families and children Promote lifelong learning and skills improvement Build capacity and networks of support Promote an efficient and inclusive labour market 2 HRSDC and Disability HRSDC has leading role on disability issues including: – Canada Pension Plan--Disability Benefit (CPP-D) • (counterpart of SSDI) – Office for Disability Issues which has Federal co-ordination function and administers: • Opportunities Fund (supports in returning to work; self-employment) • Labour Market Agreements for Persons with Disabilities (costshared with provinces/territories) • Social Development Partnerships Program—Disability (works with non-profits in furthering disability agenda) – Employment Insurance—Sickness benefit and EI training – Labour Branch administers Employment Equity Act 3 Strategic Policy Research Directorate (SPRD) Functions SPRD is a corporate research group with a broad supportive scope-working as required with HRSDC policy and program partners – Primary policy research on social development (including seniors, family and caregiving), labour market, and skills issues – Examples: • • • • Cost/uptake estimation of new program options Identifying current/future trends in program use Identifying/assessing unmet needs/gaps Developing policy-related research for general use 4 Primary Data Resources on Disability From Statistics Canada: Participation and Activities Limitation Survey (PALS) – Post Censal survey funded by HRSDC in 2001 and 2006 – Adults, children whose day-to-day activities may be limited because of condition/health – Longitudinal (5 year waves) and annual cross-sectional since 1993 – Detailed income, labour force and schooling data for Adults 15+ Survey of Labour and Income Dynamics (SLID) National Population Health Survey (NPHS) – Longitudinal (beginning in 1991) biennial survey, same initial sample – Health and related socio-economics Canadian Community Health Survey (CCHS) – cross-sectional annual survey of health determinants, health status, health system utilization and related socio-demographics From Program Administrative Sources: CPPD administrative database Longitudinal Administrative Data Planned: Provincial/Territorial Workers' Compensation; Social Assistance data bases; consultations with private disability insurers 5 – (Sample of personal tax returns maintained by Statistics Canada) Most Statistics Canada Surveys use the same "Activity Limitations" Disability Filter Questions Disability filters based on the 2000 Census: 1. Do you have any difficulty hearing, seeing, communicating, walking, climbing stairs, bending, learning or doing any similar activities? (Yes, sometimes; Yes, often; No) 2. Does a physical condition or mental condition or health problem reduce the amount or the kind of activity you can do: (a) at home? (b) at work or at school? (c) in other activities -- for example transportation or leisure? (Yes, sometimes; Yes, often; No). 6 Advantages/Issues: Current Filter Questions Use of same questions provide advantages: However: Evidence of heterogeneity of interpretation – Consistency across surveys and over time – Constancy of linkage with a functional model of disability – Clear French/English variations; other cross-cultural differences – Other socio-demographic variations—generational, age-related differences; variations with level of educational attainment Evidence of contextual effects • Example: ―Disappearance‖ of learning difficulties as middle age approaches Considerable variation when response personal vs. proxy ―False‖ negatives and positives – Issue of self-concept rather than image of others – Shifts in responses with subject of survey; preceding survey material – Perception/self-assessment varies over time for reasons other than condition change • Example: Evidence that disability perception changes with engagement in activities-such as having a job 7 Advantages/Issues: Administrative Disability Data Internally consistent/ auditable However: Lack of cross-program definitional consistency Administrative, regulatory change reduces value as longitudinal instrument Range of health, socio-economic data limited and determined by regulatory requirements 8 More Generally: Is What We Get What We Want to Understand? How do we create a stable and consistent foundation of questions which: – Create a common language/understanding – Minimize exogenous influences/noise While addressing multiple implications/meanings of disability? – Disability is a social/cultural concept related to condition and impairment: • relating to expectations and demands of activities of everyday life • often an artefact of perception, language; the design of built, instrumental environments 9 Despite Shortcomings, Research based on Filter Question Responses Points to Policy Relevant Results 1. Disability and Low Income in Non-senior Adult Population (PALS 2001/NPHS 1991-2001) People living alone/lone parents worst off in terms of both current and persistent low income Disability has greatest influence on the incidence of low income on those 45-54—people in their prime earning years Duration and Severity increase the likelihood of current and prolonged low-income Learning/Speech/Developmental conditions much more likely to experience current and persistent low income than others with disability Degree Holders doing almost as well as those without disability 10 2. Requirements, Unmet Need for Aids /Devices/Supports (PALS 2001) Some parallels with likelihood of low-income: Support gaps are widest when life-course pressures heaviest Unmet need is highest for those most likely to be raising a family, maintaining a household, consolidating a career Not necessarily persons with low income Unmet need highest when living alone or as a single parent For others: Support predominantly from those living under the same roof But other factors also come to the fore: Likelihood of unmet need increases with duration but not strongly linked with severity Likelihood of unmet need highest when needs "atypical" Access barriers getting to work and at workplaces primary in keeping many from jobs 11 3. Disability and Employment—Monitoring Trends (SLID 1999-2003) Employment rates, earnings lag that of others in the labour market However, Canada's strong labour market seems to have resulted in higher: labour force participation, employment, weeks worked, average earnings Improvements primarily among younger people with disabilities, those with post-secondary training Little change in employment for older people with disabilities (45+)—especially men, those who had low skilled work – Are also much less likely to receive training following disability onset; return to labour market after absence 12 New Insights Are also Being Developed from Administrative Data 1. Moving from Impairment to Disability (CPP-D administrative data base) Data allows examination of earnings from point of first employment to start of benefits In comparison to population, CPP-D beneficiaries typically have: – Earnings Leveling Stage: Often beginning many years prior to becoming beneficiary when earnings remain steady, while others increases Earnings Decline Stage: Often begins in 46 years immediately prior to benefit start— real decline in earnings Men 45--Annual Earnings: Population and CPP Beneficiaries $50,000 $45,000 $40,000 $35,000 $30,00 0 $25,000 – $20,000 $15,000 Stage length related to sex, age, condition. For example, often: – – No Levelling stage for persons with neoplasms (cancers), short, sharp decline stage Prolonged levelling, decline stages for those with musculo-skeletal-connective tissue conditions $10,000 $5,000 $23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 Age CPP-Pop All Men 45 13 2. Forecasting Disability Rates (Multiple sources including Workers' Compensation time-loss injuries, health statistics) Preliminary Results point to net decline in disability rates Downward pushes particularly among men: – Administrative data and health statistics showing major declines in death, impairment related to heart disease, lung cancer (predominantly men aged 45-64) – Decline in Workers' Compensation time loss injury/illness claims • shift to white-collar work and safer work environments (primarily men) – Slightly augmented by decline in significant injuries rates due to motor vehicle accidents (primarily men) Counter Balanced by: Baby boom bulge in older adults where disability rates tend to increase Some disease/health factor risk increases (diabetes, obesity) Higher labour force participation among women (higher exposure to a number of risk factors) 14 Some of the Places We May Go From Here Better understanding the data: – Examining the psychometrics of the current screening questions to understanding question semantics; relationships to proximate concepts • Testing responses in controlled experimental context Moving on what we've seen – Working together in developing disability prevention models – Focusing policy levers on income and functional loss in mid-life – Addressing employment-related access issues 15
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Three cheers for U.S. Sen. Pat Toomey.
Goodness knows we've had our differences with the conservative Republican from Lehigh County, but, as sensibility seems to be returning to Washington, we were struck by a profound statement he made Friday about the federal government shutdown.
"I never thought it was a good idea, and I never signed on to the approach of insisting we would shut down the government if we didn't defund Obamacare," he said.
"As strongly opposed to Obamacare as I am, it is pretty clear to me that the president has a different point of view, and he's still the president. He was never going to sign legislation that would effectively negate what he considers to be his signature accomplishment."
And, in our view, the same would go for President Reagan, President Clinton and Presidents Bush.
Why that would never dawn on the minions of the Tea Party, who have shamed the United States in the eyes of the world by bringing its government to a halt, proves the difference between those who are capable of governing and those who go to Washington to serve an ideology and not a country.
You can count among the latter U.S. Reps. Keith Rothfus, Tim Murphy, Mike Kelly and Bill Shuster, each of whom saw the budget showdown as an opportunity, not to negotiate and compromise on a new spending plan, but to hold a president, a nation and a long-settled health care law hostage.
Thank you, Sen. Toomey, for reminding your colleagues that good government comes with limits and that an unrealistic demand will never lead to compromise. Whether conservative or liberal, more levelheaded lawmakers like him deserve to walk the halls of Congress.
Pittsburgh Post-Gazette


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S447X variant of the lipoprotein lipase gene, lipids, and risk of
coronary heart disease in three prospective cohort studies
Majken K. Jensen, Eric B. Rimm, Daniel Rader, Erik B. Schmidt, Thorkild I. A. Sørensen,
Ulla Vogel, Kim Overvad, and Kenneth J. Mukamal
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA (MKJ, EBR);
Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark (MKJ, KO);
Department of Epidemiology, Harvard School of Public Health, Boston, MA, US (EBR);
Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical
School, Boston, MA, US (EBR); Department of Medicine, University of Pennsylvania,
Philadelphia, PA, USA (DJR); Center for Cardiovascular Research, Aalborg Hospital, Aalborg,
Denmark (MKJ, KO, EBS); Department of Cardiology, Aalborg Hospital, Aalborg, Denmark (EBS,
KO); Institute of Preventive Medicine, Center for Health and Society, Copenhagen, Denmark
(TIAS); Research Centre for the Working Environment, Copenhagen, National Food Institute,
Technical University of Denmark, Soborg, Institute of Science, Systems and Models, Roskilde
University, Roskilde, Denmark (UV); and the Department of Medicine, Beth Israel Deaconess
Medical Center, Boston, MA (KJM)
Background—Lipoprotein lipase (LPL) has a prominent role in the metabolism of triglycerides
(TG) and high-density lipoprotein cholesterol (HDL-C) and is a potential interesting target for the
development of antiatherogenic treatment. To provide deeper insight into the role of natural
variation in this gene, we investigated the association between the LPL S447X variant with lipids
and risk of coronary heart disease (CHD) in three independent, prospective studies.
Methods—The S447X variant was genotyped in case-control studies of incident CHD nested
within the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and
the Danish Diet, Cancer and Health (DCH) study, totaling 245, 258, and 962 cases, respectively.
Results—S447X-carriers tended to have lower TG and higher HDL-C concentrations than non-
carriers. The S447X variant was associated with a lower risk of CHD in the NHS, the association
was weaker in the HPFS and not statistically significant in the DCH women and men. The pooled
relative risk per minor allele was 0.74 (0.56–1.00). There was a suggestion that the associations of
the S447X variant with plasma lipids and CHD-risk were more pronounced in obese individuals in
the NHS study, but this finding was not consistent across the studies.
Conclusions—The LPL S447X variant tended to be associated with lower TG and higher HDL-
C levels, and lower risk of CHD in all three cohorts. LPL is an attractive target for clinical
intervention, but studies are needed to clarify whether greater benefit from this variant may be
conferred in some subgroups.
© 2008 Mosby, Inc. All rights reserved.
Address for Correspondence: Majken K. Jensen, Department of Nutrition, Harvard School of Public Health, 665 Huntington
Avenue, 02115 Boston, MA, USA, email@example.com, phone: (1) 617 640 0975, fax: (1) 617 432 2435.
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Author Manuscript
Am Heart J. Author manuscript; available in PMC 2011 October 31.
Published in final edited form as:
Am Heart J. 2009 February ; 157(2): 384–390. doi:10.1016/j.ahj.2008.10.008.
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Genetic epidemiology; CHD; prospective study; lipoprotein lipase; plasma lipids
In prospective observational studies, plasma triglyceride (TG) levels are directly associated
and high density lipoprotein (HDL) cholesterol levels inversely associated with risk of
coronary heart disease (CHD).1,2 However, therapeutic manipulation of TG and HDL-C as
new relevant drug targets remain elusive. Studies of DNA sequence variants located in
genes of major importance to lipid metabolism may provide important knowledge about the
role of their encoded proteins in relation to long-term measures of plasma lipids and risk of
clinical endpoints.
The lipoprotein lipase (LPL) enzyme has a prominent role in the metabolism of TG and
HDL. LPL hydrolyzes TG carried in very low density lipoprotein (VLDL) and chylomicrons
and generates excess phospholipids and apolipoproteins that are transferred to HDL.3 Thus,
high LPL activity is associated with lower TG and higher HDL-C levels.4 The gene
encoding LPL is located on chromosome 8p22, spans close to 30kb and contains 10 exons.5
Most of the identified single nucleotide polymorphisms (SNPs) with functional effects cause
loss of enzymatic function and predispose to elevated TG and reduced HDL-C.6 In contrast,
the commonly occurring S447X polymorphism in exon 9 is an intriguing exception: the
variant allele encodes a prematurely truncated LPL protein that has increased lipolytic
activity in vitro and in vivo in mice.7 The S447X variant has consistently been associated
with lower TG and higher HDL-C levels in candidate gene association studies,8–14 and its
importance was recently emphasized by its identification as one of 18 loci significantly
associated with TG and HDL-C concentration among over 350,000 SNPs examined in a
combined analysis of over 8800 individuals.15 However, its association with risk of CHD
varies considerably between study populations,12–14, 16–21 and although environmental
factors, such as smoking,22, 23 alcohol,22 and particularly adiposity,10, 11, 18, 24, 25 may
modulate the association of the S447X variant (or the tightly linked HindIII variant)26 with
plasma lipids, context-dependent effects of the S447X variant on CHD risk have received
little attention. Thus, we aimed to (1) investigate the association between the LPL S447X
SNP with plasma lipids and risk of CHD in three independent prospective studies of men
and women, and (2) examine the role of this functional variant in subgroups of participants
based on smoking habits, alcohol, and adiposity.
Study populations
The Nurses' Health Study (NHS) enrolled 121,701 female nurses aged 35 to 55 who
returned a mailed questionnaire in 1976 regarding lifestyle and medical history.27 The
Health Professionals' Follow-up Study (HPFS) enrolled 51,529 males aged 40 to 75 who
returned a similar questionnaire in 1986.28 Both cohorts are followed via biennial follow-up
questionnaires. The Diet, Cancer, and Health (DCH) study was initiated in 1993–1997 when
57,053 Danish born residents, aged 50 to 64 years and free of cancer, participated in a
clinical examination and detailed lifestyle survey.29
Endpoint and study designs
Smaller studies nested within these three cohorts were designed. A blood sample was
requested from all active participants in 1989–1990 in NHS and 1993–1995 in the HPFS.
Samples were returned by 32,826 NHS participants and 18,224 HPFS participants. Nested
case-control studies used incident CHD, with non-fatal myocardial infarction (MI) and fatal
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CHD as the outcome. Cases were identified primarily through review of medical records, as
previously described.30 Among participants who provided blood samples and who were
without cardiovascular disease or cancer at blood draw, 249 women sustained an incident
CHD between blood draw and June 30, 1998, and 266 cases occurred prior to January 31,
2000 in HPFS. Using risk-set sampling,31 controls were selected randomly and matched in a
2:1 ratio on age, smoking, and month of blood return.
In the DCH, all participants provided a non-fasting blood sample at baseline. A case-cohort
study was designed using incident CHD (fatal and nonfatal MI) as the outcome. Information
on the disease endpoint was obtained by linkage with central Danish registries via the
unique identification number assigned to all Danish citizens. Details for the assessment of
the hospital records have been published.32 In total, 1084 cases of CHD were identified and
validated. For the creation of the case cohort sample, 1800 participants were selected from
the entire DCH study at random (for consistency referred to as 'controls', although 32
individuals overlap with the CHD case group).
Laboratory analysis
Blood was obtained from mostly fasting participants in the US studies whereas Danes were
all non-fasting. Lipids were analyzed in samples stored at −150° C using standard methods.
Details on methods used in NHS/HPFS have previously been published.33 The S447X
variant was genotyped using Taqman SNP allelic discrimination by means of an ABI
7900HT (Applied Biosystems, Foster City, CA), using rs328. Technicians were blinded to
case status of the samples. Controls were included in each run and repeated genotyping of a
random 10% subset yielded 100% identical genotypes.
Statistical analysis
Hardy-Weinberg equilibrium among control participants was tested with an exact test and
no departures were observed. Multivariable regression analysis with robust variance was
used to address the associations of S447X with lipids among the controls. Relative risks
(RR) and 95% confidence intervals (CIs) for the association between genotype and CHD
were estimated using conditional logistic regression for the US nested case-control data and
Cox proportional hazard regression in DCH, using Kalbfleisch and Lawless weights and
robust variance suitable for the case-cohort data.34, 35 Sex-specific analyses were conducted
in the DCH study to facilitate comparison with the sex-specific HPFS and NHS studies.
Despite little impact on the RR's, lifestyle covariates were included in the multivariable
models because they may account for some of the heterogeneity between study participants.
In total, numbers with information available on plasma lipids, genotype, and covariates
were: 245 cases, 485 controls in NHS; 258 cases, 515 controls in HPFS; and 2629 (962
cases) in DCH.
To pool the estimates from the three study populations, we used the weighted average of
regression estimates using the random-effects model.36
We explored joint effects of S447X and smoking, alcohol, and adiposity, based on prior data
suggesting possible interaction in relation to lipids.10, 11, 18, 22–24 Tests for statistical
interaction was examined by including the cross-product term between genotype and these
factors modeled continuously. Because few participants were homozygous variant carriers,
we compared non-carriers (SS447) and carriers (S447X and XX447).
Analyses were performed using SAS 9 (SAS Institute Inc., Cary, NC) and STATA 9.1
(STATA Corp., College Station, TX).
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This study was supported by research grants HL35464, CA55075, AA011181, CA87969,
CA49449, and HL34594 from the National Institute of Health, Bethesda; M.D, the Danish
Ministry of Health, the Research Centre for Environmental Health's Fund; IMAGE, and the
Danish Cancer Society (DP00027). The authors are solely responsible for the design and
conduct of this study, all study analyses, the drafting and editing of the paper and its final
Table 1 shows baseline characteristics of cases and controls in the three study populations.
LPL S447X and lipids
The S447X minor allele frequency was 0.12 in the US studies and 0.10 in DCH. Among
controls, carriers of the S447X variant had lower levels of TG compared with non-carriers.
The association was strongest in the NHS and HPFS. S447X carriers also had approximately
10 mg/dL lower TG levels among the DCH participants, albeit not statistically significant
(Table 2). The S447X variant was also associated with a slightly higher HDL-C level, which
was most evident among DCH men. The TG to HDL-C ratio reflected these associations.
LPL genotype and risk of CHD
The S447X variant allele was more frequent among controls than among those who
developed CHD. The S447X polymorphism was associated with risk of CHD in a co-
dominant fashion in the three studies, although only statistically significant in the NHS
(Table 3). In a pooled analysis, the adjusted RR was 0.74 (95% confidence interval, 0.56–
1.00) per copy of the minor allele.
Because use of lipid-lowering drugs, especially among cases, may obscure our findings, we
repeated our analyses in samples restricted to participants who did not report use of such
drugs. Although a sizable number of the cases were excluded, we found that the associations
between the S447X variant and risk of CHD were stronger in all three studies (NHS: 0.55,
0.34–0.90; HPFS: 0.65, 0.44–0.96; DCH women: 0.88, 0.56–1.30; DHC men: 0.83, 0.62–
1.11). The pooled estimate after these exclusions was 0.75 (0.62–0.90).
Exploratory subgroup analyses
We did not observe any modification of the association between S447X genotype and
plasma lipids, by smoking, alcohol, or sex (data not shown). However, there was some
evidence that the S447X variant had the most pronounced association with TG and HDL-C
concentrations among the overweight and obese individuals. The mean TG to HDL-C ratio
is shown according to S447X genotype and BMI in figure 1. In the NHS and DCH women,
differences in the TG to HDL-C ratio were largest among the overweight and obese
individuals, whereas differences between genotype groups were smaller in magnitude across
BMI groups in the HPFS and DCH men. Similar results were observed when waist
circumference was used (data not shown). However, tests of interaction between the S447X
variant and BMI or waist circumference were not statistically significant in any of the
The suggestive evidence for a stronger effect of the S447X variant among the overweight
and obese women was also reflected in analyses of CHD risk in the NHS. The S447X
variant was not associated with CHD among NHS participants who were normal weight
(p=0.5), but the association was stronger in the overweight (p=0.02) and strongest in the
obese (p<0.01) (p for interaction= 0.01; data not shown). An analysis using waist
circumference showed a similar pattern (p for interaction=0.01). Although the S447X
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variant had a stronger association with CHD among obese HPFS men, the confidence
intervals were broad and the interaction was not statistically significant. There was no
interaction between BMI or waist circumference on risk of CHD in the Danish population.
In three independent studies, we found that carriers of the LPL S447X variant tended to have
lower TG and higher HDL-C levels compared to SS447 homozygotes. Concomitantly, the
risk of CHD was lower among carriers.
The association between the S447X variant and elevated TG and lower HDL-C has been
shown in several studies,8–14 and this association is supported by animal data showing that
the S447X variant produces a LPL protein with higher lipolytic function.7 Although
epidemiologic data on the risk of CHD associated with the S447X variant have not been
completely consistent,12–14, 16–21 the lower risk of CHD we observed among S447X carriers
was recently supported by a comprehensive candidate-gene association study of 142 loci
where only two variants that are tightly linked with the S447X SNP were consistently
associated with coronary artery disease in two case-control studies.37
Although low-density lipoprotein cholesterol has been the main therapeutic target for high
cardiovascular risk patients, renewed attention has focused on the potential risk reduction
that may be achieved by HDL-C manipulation.38 However, trials of promising HDL-C-
increasing drugs such as CETP inhibitors have been consistently negative to date.39, 40
Given this, other targets have become more attractive, and indeed clinical trials targeting
LPL with specific activators (NO-1886) or with gene therapy using the S447X variant are
planned.41, 42 Studies of genetic variants may provide important insight into the expected
effects of pharmacological manipulation of HDL's complex metabolism. For example,
studies of genetic CETP variants showed several of the adverse cardiovascular effects –
including hypertension - that were ultimately seen in clinical trials, and indeed these genetic
studies were rather mixed with respect to risk of CHD despite positive effects on HDL-C
levels.43–45 Thus, we believe it crucial to examine the S447X variant in LPL in well-
designed prospective studies of healthy population samples prior to use of LPL activators in
large-scale trials. In addition, exploratory subgroup analyses may give hints to the most
appropriate study population for trials of LPL activators on the basis of maximal sensitivity
to its potential benefits. Such information may prove critical for the design and success of
clinical trials.
We found some evidence that the association of S447X with lipid concentrations and CHD
risk might be greatest among overweight and obese individuals. Differences in TG and
HDL-C concentrations between carriers and non-carriers of the S447X variant, and the
closely linked HindIII SNP, have previously been reported to be greater in participants
characterized by central or general obesity.10, 11, 24, 25 However, there has been relatively
little research on risk of clinical endpoints in potentially susceptible subgroups of the general
population. An increased efflux of non-esterified fatty acids from the adipose tissue to the
liver among obese individuals and the accompanying increase in the secretion of VLDL may
be one of the main forces driving the atherosclerotic effects of obesity. Thus, it is possible
that the S447X variant could be of greater importance among individuals where the normal
lipid transport system is under stress to maintain normal lipid levels.
One of the strengths of this analysis was the ability to address the role of the same variant in
three independent studies of generally healthy populations. However, the populations were
derived from different countries with some marked differences in lifestyle and levels of
cardiovascular risk factors. A slightly higher baseline risk in the DCH study could dilute the
Jensen et al.Page 5
Am Heart J. Author manuscript; available in PMC 2011 October 31.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript


text:
Sheet material useful to form a coded retroreflective mark comprises a retroreflective base sheet and a cover film adhered over the base sheet and precut to form a plurality of removable sections. The cut sections are arranged in a predetermined pattern such that removal of different sections to expose the retroreflective sheeting under the sections provides different codes that may be read and distinguished by photoscanning equipment.
1. Elongate sheet material wound onto a storage roll and useful to form a coded retroreflective mark, said sheet material comprising a retroreflective base sheet having a planar front face and an opaque flexible polymeric cover film removable adhered over said planar front face by a layer of pressure-sensitive adhesive, said film being cut along a plurality of lines in a pattern that forms a plurality of contiguous parallel sections that are aligned along the longitudinal axis of the sheet material, comprise sections having an identical size and shape, and are individually removable to expose the portion of the retroreflective base sheet underneath the section, the sections being arranged in a predetermined pattern such that removal of one or more different sections provides different codes that may be read and distinguished by photoscanning equipment.
Coded retroreflective marks offer a number of advantages for marking articles to be handled by automated equipment. For example, in comparison to coded marks formed from a series of black and white stripes such as used to mark grocery items, retroreflective code marks may be more rapidly and reliably read; they may be read at greater distances; and they permit wider latitude in unfavorable conditions--misalignment of an article or dirtying or obscuring of a mark--without preventing sensing of the mark. Further, retroreflective code marks may conveniently be reused.
However, maximum exploitation of retroreflective code marks has been prevented by lack of convenient, accurate, and inexpensive techniques for forming coded marks. The deficiencies of existing techniques can be illustrated by one previously used system, which uses code plates formed by adhering a sheet of retroreflective material to a support member and then covering the retroreflective sheet with a metal face plate in which a desired pattern of openings has been stamped. Deficiencies of this system include the high cost of preparing each code plate; the inconvenience of maintaining an inventory of different cover plates each stamped with a different pattern of openings; and the opportunity for error, since stamping of the cover plates is usually performed at a location removed from the point of application of a mark to an article.
The present invention provides a new sheet material that may be supplied in a standard form, i.e. the same for each object in a set of objects to be marked, and then rapidly encoded at a job site to provide a different mark for each one of the objects. Briefly, this new sheet material comprises a retroreflective base sheet and a cover film removably adhered over the base sheet and precut into a plurality of sections. The cut sections are individually removable to expose portions of retroreflective sheeting under the sections, and the sections are arranged in a predetermined pattern such that removal of different sections provides different codes that may be read and distinguished by photoscanning equipment.
Sheet material of the invention may be used in the form described, e.g. by adhering it to an article to be marked; or it may be adhered to a support member to form a code plate that is then mounted on the article. Further, the sheet material may be supplied in discrete sheets or in elongated tape form generally wound in a storage roll.
Removal of cut sections of cover film is very rapid and convenient. Further, since the sections are machine-cut, their location is precise. No effort is needed to position a retroreflective tape, since formation of a mark requires only the removal of precut sections of cover film. pg,3
FIG. 1 is a perspective view of an illustrative sheet material of the invention with the thickness of the tape shown greatly enlarged over true scale;
FIG. 2 is a top view of a portion of a different illustrative sheet material of the invention;
FIG. 3 is a top view of another illustrative sheet material of the invention;
FIG. 4 is a top view of an illustrative code plate of the invention; and
FIG. 5 is a greatly enlarged section through a portion of the code plate of FIG. 4 taken along the lines 5--5 of FIG. 4.
FIG. 1 shows a portion of an illustrative sheet material of the invention 10 in tape form. This sheet material comprises a base retroreflective sheet 11 and a cover film 12 adhered to the base sheet by a layer of adhesive 13. The cover film is precut to form a series of removable sections 12a, b, c . . . . To form a code, one or more of the sections is peeled away in the manner illustrated for the section 12b.
The cover film may be cut into a wide variety of patterns to tailer a sheet material of the invention for a particular use. Two additional useful patterns are shown in FIGS. 2 and 3. In the tape 15 shown in FIG. 2, the removable sections 16 of cover film are in groups 17 spaced along the length of the tape. One use for such a tape is to mount it on a support structure with the groups of removable sections located at parts of the structure, e.g. storage containers, that need to be separately identified. In the sheet material of the invention 19 shown in FIG. 3, which takes the form of a square sheet, the removable sections 20 are separated from one another and form a code matrix. The removable sections may be in a variety of geometric forms other than the circles shown in FIG. 3, e.g. triangles, squares, etc.
FIGS. 4 and 5 show a code plate 22 made by adhering sheet material of the invention 23 to a support member 24 such as a metal or plastic plate by a layer of adhesive 25; the support member may be either rigid or flexible. Means for attaching the code plate to an article may be carried on the back surface of the support plate, such as a layer of pressure-sensitive adhesive, a foam-backed adhesive tape, or a polymer-based magnet such as taught in Blume, U.S. Pat. No. 2,999,275.
The code plate 22 illustrated in FIG. 4 has four sections of cover film removed to expose retroreflective sheeting 26 in the areas 27, 28, 29, and 30. The section 27 may serve as an alignment section: photoscanners intended to read the code plate can be programmed to operate only if the section 27 is sensed by the photoscanner; since section 27 is smaller in size it will generally be sensed only if the whole code plate is in proper alignment.
The retroreflective sheeting 26 used in the illustrative code plate 22 is of a cellular type described in McKenzie, U.S. Pat. No. 3,190,178. As shown in FIG. 5 such a sheeting may include a bottom sheet 32 in which a layer of glass microspheres 33 is partially embedded, and a transparent top film 34 supported above the layer of microspheres by a network of adhesive bonds 35. The latter may be formed by pressing binder material from the botton sheet into contact with the cover film so as to flood the microspheres in the bond area and separate the space between the bottom sheet and cover film into a plurality of cells. The described cellular sheeting not only exhibits high reflectivity, but it may be conveniently cut into sections without disturbing the hermetic seal above substantially all of the micropheres in the sheeting.
Another useful flat-surfaced retroreflective sheeting is taught in Palmquist et al, U.S. Pat. No. 2,407,680. In general, retroreflective sheeting having a flat front surface is preferred for the best adhesion and for lasting cleanliness of exposed code portions.
The cover film is typically a flexible opaque polymeric film (by "opaque" it is meant that the film prevents transmission of light rays that would actuate photoscanning sensors as they are commonly used in automated material handling). Most often the cover film is pigmented black, though it may also be pigmented some other color since the contrast retroreflective sheeting and even colored film is sufficient to allow a photoscanner to distinguish between them. A pressure-sensitive adhesive is typically used to adhere the cover film to the base retroreflective sheet. Non-setting pressure-sensitive adhesives are available which retain a rather constant adhesive nature for extended periods of time. The result is that a section may be removed immediately upon manufacture of material of the invention or at some later time when it is desired to form a code or change a code.
In manufacturing sheet materials of the invention, a layer of pressure-sensitive adhesive is typically coated onto the cover film, and the cover film then laminated by means of the adhesive to a base retroreflective sheeting. Thereupon the cover film is precut by a technique that typically does not result in cutting of the base retroreflective film. Rotary dies or steel rule dies that cut to a controlled depth provide one useful technique. Preferably the cutting die is heated when a polymeric cover film such as a vinyl cover film is used, because the heat will cause the cover film to shrink slightly after cutting. The cut sections of cover film thus have a slight space between them (see the space 36 in FIG. 5), so that removal of the sections is made more convenient.
As the drawings illustrate, the cut sections are generally in a predetermined pattern such that removal of one or more different sections provides different codes that may be read and distinguished by photoscanning equipment. The cut sections typically include sections of identical shape, and the sections are often contiguous to one another, as shown in FIGS. 1, 2, and 4. The sections are also preferably in alignment along a longitudinal axis as is true for each of the embodiments shown in the drawings (the FIG. 3 embodiment also includes sections that are in alignment along a transverse axis).
In a specific example of the code plate shown in FIGS. 4 and 5, there are eleven cut sections, with the eight middle sections being used to form a binary code. These eight sections were each about 1/2 inch by 11/2 inches in size, which provides very adequate sensing. Larger or smaller sizes can also be used.
Patent Citations
Referenced by
Original Image


text:
According to metro.co.uk, speculations indicate that the item was taken down by eBay as the listing contravened its rules, but it is yet to be confirmed.
The hysteria surrounds the simple yet addictive mobile game that was recently taken down by its Vietnamese developer, Nguyen Dong, who had revealed that the game raked in 50,000 dollars per day in revenue.
The report said that the 16 GB iPhone 5 with the game immediately lured gamers into offering 7,000 dollars within a couple of hours the bid was posted and a similar bid inclusive of a second-hand iPhone attracted a 400 pounds bid on the site.


text:
Chula Vista, CAUSA 91915
January 24, 2013
I have a 1 year old border collie/swiss mountain dog mix. Very friendly, loves people and other dogs. She will play with anything and loves to run and hike.
Don't know any yet!
People a lot of cool people with the same interest, and to have dog meet some new pals.
I'll follow the group at this point, I don't know any places.
I'm Wilson, I just moved out here with my 1 year old border collie, I am 20 years old.
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


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Help support Wordnik by adopting your favorite word!
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Log in or sign up to add your own related words.
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missanthropist commented on the word enkyklein
Greek To surround.
July 11, 2008


text:
Joey's Shrimp House(773) 772-1400
1432 N Western Ave
Chicago, IL 60622 | MAP
Chicago, IL 60622 | MAP
| Share |
The Savoy
Contemporary, Seafood, Bar
Contemporary, Seafood, Bar
Chez Violette
Caribbean, Diner
Caribbean, Diner
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Fish and Chips, Seafood
The Grill Room, a casual restaurant/bar in Chicago, arguably has the best steak in Chi-Town. Also, if you do like to have a few drinks here and there, you will not be disappointed because they seem to be a bit heavy handed while they're pouring (if y ...
Fish and Chips, Seafood
The food was really tasty. The Yassa chicken was well seasoned. However, it was a bit tough for my taste. No matter, the place is great. Loved the cabbage. Try it.
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3/09/2013...omg... place a order for fish and wings...the wings was old the fish was so HARD...and the fries were bits and crumbs...this will be my last time here... plz find another place to eat at..
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This was my first time at Sharks at this location. My first impression was that the place did not look clean. There were two young ladies ahead of me, so I asked them how was the food? They replied, good. So, I decided to try it. I ordred 10 wings an ...
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text:
The Coalition for Equal Marriage has released a video designed to support the push for marriage equality in Britain.
Watch the video, entitled Homecoming, below:
Writing in a piece for PinkNews.co.uk, the film's Director, Mike Buonaiuto, said:
"One day I would like to marry my partner of almost 5 years. And the celebration of our commitment should mean no more or less than any other straight couple. I made the film to promote change and also inspire others to use their creativity to support equality."
The Coalition for Equal Marriage is a grassroots response to an organized and religious conservative-backed opposition group determined to derail the British Government's push to legalize marriage equality.
Currently, there is an ongoing Government consultation on marriage equality, however ministers have been clear that this is to gather feedback on issues surrounding marriage equality and not on whether marriage equality should be law because that question has already been decided.
Marriage equality has received the full backing of Conservative Prime Minister David Cameron and while the Anglican church as a whole has acted against the move, a number of religious leaders have also said they support civil marriage equality as a matter of fairness.
Related Reading:
Cardinal Defends 'Gay Marriage is Like Slavery' Comparison
British Cardinal Compares Gay Marriage to Legalizing Slavery
Lord Carey's Fact-Free Case Against Gay Marriage Examined
Read more: british government, british politics, civil partnerships, civil rights, conservative party, gay rights, lgbt England, lgbt europe, lgbt rights, lgbt uk, lord carey, marriage equality, same-sex marriage uk
Image taken from video no infringement intended.
Thank you!
thanks :)
Loves conquers all bounderies and people should be free to give their love to whoever they choose. Why are some people so against people of the same sex being in a loving relationship. Time to broaden their narrow minds.
Poor illness people, gay marriage is un natural !
This is why I love the Brits. America for all their liberalism. would have never produced a video like this.
That was just beautiful! It should move many people.
That said, I DO wish LGBT material wouldn't glorify the Military.
LGBT people ought to be in the forefront in fighting for a World Without War {i.e., Patriarchal Domination}.
However, that all being said, and my honest opinion --
it WAS still a BEAUTIFUL picture.
I can hardly believe that those men were "only acting" -- it looked so real, so intimate.....
some aspect of their real lives WAS being shown on the screen.....
Yes, moved to tears. And, in context, the Military association WAS appropriate.... as there is that heterosexual parallel..... on all levels.
I made a video about why Homosexuals should have equal rights. Its at my YouTube channel Zarrakan, and heres the link:
Watch it, share it, and join the fight against the evil Homophobes.
What a WONDERFUL statement. Thanks for posting Steve.
Thank you to The Coalition for Equal Marriage for the release of the video A very good production. I wish HRC woulod produce something like it. Thanks for the article Steve.
Disclaimer: The views expressed above are solely those of the author and may
not reflect those of
Care2, Inc., its employees or advertisers.
Gerald, Do you condone the use of leg-hold traps and snares, too?
Thanks for this! I think the most important here is the shape of the bird bath! If it's somehow large,but…
My kitties get along very well but I have seen this and it's sad.


text:
Innovative Course-Building Group
This site is a blog that is about designing courses. The blog is developed by a group that "is a grass-roots social network for learning that supports teaching faculty and staff across disciplines. We use civic issues as a catalyst for designing engaging courses that will result in important student learning."There is a variety of topics and there are links to archived materials back to September 2008.
Material Type: Social Networking Tool
Technical Format: HTML/Text
Date Added to MERLOT: June 01, 2011
Date Modified in MERLOT: June 01, 2011
Submitter: Cathy Swift
Reviewed by members of Editorial board for inclusion in MERLOT.Editor ReviewVery good quality; in queue to be peer reviewedavg:
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545 comments on "How to pass journal Entry in Tally.ERP 9"
Comment navigation
Please tell me for a manufacturing company,there is huge losses in current year and there is no work in progress in the beginning of this year.What is the treatment to pass entry in tally??
How to pass journal entries salary account
Dear Sir,
How to pass correct entry for when i give cash to any one for company exp purpose as an loan & adv to XYZ A/c for RS 5000/-(entry – adv to XYZ A/c Dr. -5000/- to Cash A/c -5000/- pass by payment voucher) and then he give the original exp. submitted against adv for site exp. then (entry in tally – Exp. A/c Dr. -5000/- To Adv to XYZ A/c- 5000/- pass by jounal voucher). but when his exp include to given the money for as a adv to ABC A/c. 1000/-then what entry is correct as per accounting policy :- i have given a example for
1. pass by journal entry
Exp. A/c Dr. 4000
Adv to ABC A/c Dr. 1000
To Adv to XYZ A/c 5000
2. pass by journal & receipt and payment en
A. pass journal:-
Exp. A/c Dr. 4000
To Adv to XYZ A/c 4000
B. pass receipt voucher
cash A/c Dr. 1000
To Adv to XYZ A/c 1000
C. pass payment entry
Adv to ABC A/c Dr. 1000
To Cash 1000
give me suggestion for what policy is correct for accounting purpose.
Dear Sir,
I want to know that how to Deduct TDS on Salary and how to prepare TDS receivables entries in tally ERP 9.
types of ledger&voucher to be passedfor vat return
in kotak bank statement i have received 40000 and 20000 against Sweep transfer and 80000 paid against sweep transfer automatically pls tell me how to pass entry in tally for above transaction
When I wanted to enter Telephone bill for accrual purpose, my boss is insisting on the today's date as date of entry in Journal voucher entry and not the Bill date as date of entry.
How to resolve this issue, please help.
Thanks very much.
plz urgent sir………..
our travels company 02/01/2014 advance car rental received amount is rs 1000
04/01/2014 full amount payment amount is rs 4500
total trip amount 5500,trip on 03/01/2014
recieved from our company (rav co)
plz solve the entry
plz urgent sir………..
our travels company 02/01/2014 advance car rental received amount is rs 1000
04/01/2014 full amount payment amount is rs 4500
total trip amount 5500,trip on 03/01/2014
received from our company (rav co)
plz solve the entry
dear sir
if a company purchase 103500 good with 50000 cash payment and 53500 on credit later company return good of rs 48000 what will be the entry plz let me know in detail
Please guide me for provisional entry pass for electricity bill against not recd the bills.
How to punch in tally, that if u purchased air ticket for Rs.5000.00 , so air ticket agent give as commission of Rs.500.00 from purchased of air ticket, so how to punch in journal entry.
How to punch in tally, that if u purchased air ticket for Rs.6000.00 , so air ticket agent give as commission of Rs.500.00 from purchased of air ticket, so how to punch in journal entry.
sir i have question that i sold a car to a party on 500000 he gave me 200000 cash and rest bank finace how to entry in tally
Sir i would like to know entry to be passed for purchase and sale of air ticket by travell agency business
How can i enter a provision entry of advance rent with security & should i charge the TDS also in same
sir for which item we hv to pass journal entry???
like my friend saying that if some expenses is outstanding then you have to pass journal entry first and while making payment make payment voucher ….
sir plz suggest me with full example ….
and also that when we create journal and after making that voucher still the balance remain in correspond account
Dear Sir,
i just want to know if the director use there personal credit card in the company than how the entry will made & it is use for the company exp.
there are 3 case:
1 payment made by director
2 payment made by the company]
3 payment made by the other company
Our company take a loan from private institution & we pay amount in per month EMI including interest
so what is the JV and in which group ?
We take 50,000,000/- & Interest rate 13.05% Flatt Base
How can we pass the entry of bank statement in company accounts book, like bank Dr amount where show in account book (Dr or cr)
In a company owner capital Account Amount Received from Jewel loan on 1.6.14. and now time Jewels Replace how can entry in tally plz help
Dear Sir,
How to pass the TDS refund entry + interest received & also adjustments for income tax paid from tds amount. example as below :
TDS deducted = 7236
Income Tax paid = 3007
TDS refund = 4229
TDS refund interest = 273
how to pass entry in tally 9 of, purchase computer printer with cash charged input vat@ 4%.
Dear Sir,Dear Sir,
we are taken 2-3 tabs for repair from the party & after repaired that tabs we given to the party with service tax bill but i want to know how to pass the entry in tally which is charges paid for repaired the tabs. We don't have any bill or challan we paid cash only.
Urget Please,
I am working in a company where I got an amount from my boss, so what & how I shall make entry in tally?
I can not understand and pass
the journal entries please Help me sir/madam
Dear sir,
i have some doubt please give me ur suggestion..Assume if i paid the telephone charges in cash what is the entry for this in tally.and also paid in dr card what is the entry for both..
my party give me extra cash against bill exm. bill is Rs. 11000/ but he was given to me 11500/- so how the pass journal enteries.
How to enter packing materiel(indirect exp) Purchase entry ?
Construction work party amount received which account labour payment which account
Respected sir,
thanx. for previous reply. i have another query in our company when marketing executives go outside for company work, company paid them eg. 1000/- rs. then we make voucher and when exuctives returned then they give exp. details i.e. 850/-rs. made by him and returned balance to company(i.e. 150/-) or if they didnt return we deduct it from salary. then how to maintain entry in tally.
I have PPF account & i got interest than how pass PPf and PPf interest entry in tally & in whixh grouping.
hello sir,
what will be the entry in tally of amount transfered from bank into the credit card.
please tell me both entry payment as well as its journal entry
sir how to do sal or sal adv entry in tally ?which entry will be journal or payment ? what willbe the head of employee a/c either loan adv account or salary a/c?
dear sir
i want the about the entry of service tax,tds,capital goods and misslenance exp entry how to pass in tally ERP 9.


text:
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hazrul izam's BadgesPartnerBon Appetit - Navigator
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©1978 Lawrence Block; (P)1998 Recorded Books, LLC
"The perfect title"
Fun story, nice twists and turns and since it is read by one of my favorite narrators.
Well you can't ask for more on slant weekend.
VERY entertaining too!
"love this series"
I wish there were more in this series with Block and Ferrone
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