text:
Venere.com is the perfect place to make all of your hotel bookings in Hoscheid, Luxembourg! Check out our 10 Hoscheid hotels, including a wide selection of accommodations, ranging from the super luxurious 5-star to the budget-conscious 2- and 1-star. Get the best value for your money with Venere. No matter what kind of accommodations you are looking for - ski, family, spa, sports, business, wellness, city center, adventure, golf or boutique hotels - we have the perfect hotel for your next vacation or business trip. Not sure which type of Hoscheid hotel you want? Browse the 10 hotels on our interactive map to see exactly where they are located in Luxembourg. Carefully read the detailed hotel descriptions for even more information on the Hoscheid area and the hotel you are interested in booking. Find out about the nearby tourist attractions, such as museums, beaches, shops, monuments, churches and exhibition centres. Learn all you need to know about each of the 10 accommodations offered at Venere. Even find hotels with onsite restaurants, pools, gyms, internet, concierge and business services. When traveling to Hoscheid, Luxembourg - for work or pleasure, a quick weekend or an extended stay - check out Venere.com first. Venere has something to fit any budget. Get amazing discounts on Hoscheid hotels. We update our inventory daily and are always adding new deals and sales for our 10 accommodations. Treat your special someone to a romantic weekend or book a fun-filled vacation for the entire family. Start by searching our easy-to-navigate website. Simply type Hoscheid into the search box, then put in your travel dates and the number of rooms you need. Then simply look through all of the available accommodations among the 10 that Venere has to offer. Browse through all of the Hoscheid hotels in the list and choose the ones that look good. Our gallery of photos will let you see what the hotel looks like inside and out. Read hotel descriptions for an overview of the hotel you chose in Luxembourg. Be sure to check for any available freebies, such as free Wi-Fi, breakfast and parking! Get all of the information about your room and location before making your final choice. Check out the hotel reviews from genuine Venere guests and Tripadvisor comments to see what others have to say about your Hoscheid, Luxembourg accommodations. Learn all you can about your hotel choice and them book the perfect vacation accommodations with Venere.
Hoscheid Hotels
Search for Hotels in Hoscheid
Trending now in Hoscheid
Hotels in Hoscheid
- Most booked
Hotel des Ardennes
Excellent 4.2 / 5 ( 22 reviews )
7 people looked at this hotel in the last hour
Hotels within 5 miles of Hoscheid
Cocoon Hotel La Rive
Excellent 4.3 / 5 ( 15 reviews )
18 people looked at this hotel in the last hour
Cocoon Hotel Belair
Excellent 4.2 / 5 ( 24 reviews )
11 people looked at this hotel in the last hour
Hotel St. Fiacre
Excellent 4.3 / 5 ( 7 reviews )
10 people looked at this hotel in the last hour
Hotels within 10 miles of Hoscheid
Hotel-Restaurant Petry
Excellent 4.0 / 5 ( 1 review )
23 people looked at this hotel in the last hour
Hôtel - Restaurant Victor Hugo
Excellent 4.0 / 5 ( 8 reviews )
16 people looked at this hotel in the last hour
Hotel Heintz
No Guest Reviews yet
12 people looked at this hotel in the last hour
Hotel Belle-Vue
No Guest Reviews yet
10 people looked at this hotel in the last hour
Excellent 4.4 / 5 ( 10 reviews )
8 people looked at this hotel in the last hour
Grand Hotel de Vianden
No Guest Reviews yet


text:
New York Comic Con starts tonight and MAD will there! Here are the MAD-centric "highlights":
New York Comic Con starts tonight and MAD will there! Here are the MAD-centric "highlights":
Anyone in the radio and music business knows that MAD illustrator and Art Director Sam Viviano often moonlights as the cover artist for the publication Hits' annual anniversary issue! This year, to celebrate their 26th (Big Deal!
From MAD #273, September 1987
Writer: Lou Silverstone
From "MAD's Video Reviews", MAD #293, March 1990
Dallas is back! Massively popular in the 1980s, the nighttime soap is returning to television tonight, continuing the epic story of the wealthy Ewing family and all of the drama that comes with their 1% lifestyle. What better way to catch up on the saga than with MAD's 1981 parody, "Dullus"?
The National Cartoonists Society held the 66th Annual Reuben Awards in Las Vegas this past weekend. The big winner at this year's ceremony was none other than MAD's very own Tom Richmond, who took home the Reuben Award for Outstanding Cartoonist of the Year! The Reuben is the highest honor a professional cartoonist can receive.

subset: commoncrawl


text:
The Metropolitan Opera Announces Free Summer Events
The Metropolitan Opera announced the return of its popular free outdoor series of summer events. For the third consecutive year, the Met will present operatic recitals in parks in all five boroughs, as well as a ten-day festival of encore screenings from the Met's popular HD transmissions in Lincoln Center Plaza.
The Met's 2011 Summer Recital Series, presented in collaboration with City Parks Foundation, will feature six free concerts beginning July 11 and concluding July 28. The series begins July 11 at Central Park SummerStage with an 8:00 pm recital starring three rising Met stars: soprano Angela Meade, mezzo-soprano Jennifer Johnson Cano, and tenor Dimitri Pittas. The same three singers will perform on July 13 at 7:00 pm in Brooklyn Bridge Park (Brooklyn). Later recitals in Crotona Park (Bronx), Clove Lakes Park (Staten Island), Socrates Sculpture Park (Queens), and Jackie Robinson Park (Manhattan) will feature soprano Layla Claire, mezzo-soprano Renée Tatum, and bass-baritone Ryan Speedo Green. Pianist Bradley Moore will perform with the singers at all six recitals. No tickets are required for any of the performances; a complete schedule is available below.
The popular Summer HD Festival returns for a third year, featuring ten consecutive nights of free encore screenings from the Met's Peabody and Emmy Award-winning Live in HD series. This year's festival will run August 27 - September 5; titles and starting times for the screenings will be announced closer to the festival date. No tickets are required for the festival. More than 3100 seats will be available each night, plus space for overflow crowds of more than 4000 on the plaza.
"Experiencing grand opera projected on to the façade of the Met under a balmy summer night sky has become a popular experience for New Yorkers and tourists alike," said Met General Manager Peter Gelb. "I'm pleased that we are continuing for the third year in a row."
The Met: Live in HD, produced in association with PBS and WNET is made possible by a generous grant from its founding sponsor, the Neubauer Family Foundation.
Bloomberg is the global corporate sponsor of The Met: Live in HD.
About The Met's Summer Recital Series
The Met's Summer Recital Series will feature arias and duets from a variety of operas. The 8:00 pm Central Park SummerStage recital on July 11 is approximately two hours long, and the 7:00 pm Brooklyn Bridge Park recital on July 13 will run approximately ninety minutes. All subsequent recitals in the series-held on Tuesday and Thursday evenings from July 19 through July 28-will begin at 7:00 pm and run approximately one hour.
"City Parks Foundation is thrilled to be partnering with the Metropolitan Opera for the Summer Recital series for the third year," said David Rivel, Executive Director of City Parks Foundation. "SummerStage aims to bring high quality, free performances into the diverse neighborhoods of New York City, and the Summer Recital Series will be a highlight for many communities this summer season."
About Author
- Casting Roundup: Sarah Chalke, Kim Raver Headline New Pilots
- ADVENTURE TIME Headed to the Big Screen?
- Pilot Season Roundup: Colm Feore, Daniel Stern, Dave Annable to Star in New Shows
- James Franco to Star in New Fox Comedy, WHY HIM?
- Christopher Meloni to Star in WGN America's Slave Drama UNDERGROUND
- Check Out Alex Dunphy's Full College Essay from Latest MODERN FAMILY Episode
- Photo Flash: HBO Reveals Key Art for GAME OF THRONES Season 5
- Syfy to Honor Leonard Nimoy with Special Programming This Sunday
- Grammy Winner Kelly Clarkson Exclusively Premieres New Music from New Album on MTV, VH1 & CMT First
- CONSTELLATIONS' Jake Gyllenhaal and Ruth Wilson Set for THEATER TALK This Weekend


text:
Digicel Jamaica has launched a mobile TV service over its GPRS network, according to The Jamaica Observer. Digicel has partnered with Jamaican national station CVM TV and music channel Hype TV to offer "around-the-clock live local programming, including well-loved soap operas, news bulletins, music videos and sports programmes". This is a streaming service, although the frame rate isn't going to be crash hot. The company plans to launch made-for-mobile channels this year and extend the service to the other 22 markets in which it serves (mostly Caribbean, with some Central American countries).
Comments have been disabled for this post


text:
Palit GeForce 9600 GSO Sonic 768MB - Power Consumption TestsIn an already crowded graphics card market, NVIDIA decides to confuse us a little bit more with a new model.
Power Consumption Tests
Using our new PROVA Power Analyzer WM-01 or "Power Thingy" as it has become quickly known as to our readers, we are now able to find out what kind of power is being used by our test system and the associated graphics cards installed. Keep in mind; it tests the complete system (minus LCD monitor, which is plugged directly into AC wall socket).
There are a few important notes to remember though; while our maximum power is taken in 3DMark06 at the same exact point, we have seen in particular tests the power being drawn as much as 10% more. We test at the exact same stage every time; therefore tests should be very consistent and accurate.
The other thing to remember is that our test system is bare minimum - only a 7,200RPM SATA-II single hard drive is used without CD ROM or many cooling fans.
So while the system might draw 400 watts in our test system, placing it into your own PC with a number of other items, the draw is going to be higher.
Checking out power, we again see the GSO draws a little more when compared directly to the GT.
PRICING: You can find products similar to this one for sale below.
United States: Find other tech and computer products like this over at Amazon's website.
Australia: Find other tech and computer products like this over at PLE Computer's website.
Canada: Find other tech and computer products like this over at Amazon Canada's website.
Further Reading: Read and find more Video Cards content at our Video Cards reviews, guides and articles index page.
Do you get our RSS feed? Get It!
Latest News Posts
- Nintendo speaks out against VR and AR efforts from Microsoft, Sony
- Over 83,500 sign petition for Reddit CEO to step down
- Pricing on the ASUS Radeon R9 Fury STRIX leaked
- Robot accidentally kills worker in Volkswagen auto factory
- Meet the Nintendo PlayStation prototype
Forum Activity
- Accell Home or Away USB Surge Protector Review
- Define S 47 [Buildlog 03.07.2015]
- Power loss - Event 41 Kernel Power
- ASRock Beebox (N3000) Fanless Small Form Factor PC Review
- AMD Radeon R9 Fury X Video Cards in CrossFire
Press Releases
- Sharkoon Gamer Mouse with Bungee Hub - MSRP 47.99 Euros
- SMITE on Xbox One will have Australian Servers with Open Beta launch next Week
- Marble Monster is intensively addicting and action packed!
- ROCCAT Announces Taito Control Gaming Mousepad
- Lite-On Introduces Low Latency M.2 PCIe SSDs for Cloud Vendors


text:
22 Nov 2005 // 1:00 AM
While most of the target audience for the movie may not remember the TV version, Schultz's Honeymooners unfortunately forgets what was most appealing about the show.READ more
16 Nov 2005 // 1:00 AM
Timeless terror needs more than goop and glop. Only one Fly film even tried to get it right.READ more
15 Nov 2005 // 1:00 AM
As pointed out in a making-of featurette, John Wayne and Maureen O'Hara had such 'chemistry' in their films together that moviegoers took them to be a real-life couple.READ more
10 Nov 2005 // 1:00 AM
However much the camera lingers on Terrence Stamp's features or Silvana Mangano's heavily made up face, the characters remain corporeally opaque, more embodiments of ideas than urges and appetites.READ more
9 Nov 2005 // 1:00 AM
Frankly, having sat with my kids through Transformers, Pokemon, Hello Kitty, Bratz, and My Little Pony videos, the Bionicle series is a work of comparative genius.READ more
8 Nov 2005 // 1:00 AM
Tim Burton's movie is mostly perky, slightly edgy, and dully episodic.READ more
7 Nov 2005 // 1:00 AM
Far from being a sermon, the movie is no bromide against girlish promiscuity, but a mature consideration of love found through 'unconventional' means.READ more
4 Nov 2005 // 1:00 AM
Nolan's Batman is perpetually knotted up, unable to forget his dead parents, seeking a vague solace in his hard body's capacity for violence.READ more
31 Oct 2005 // 1:00 AM
Considering that the plot, such as it is, involves a pair of murders committed by Albert's poisonous viper, the jaunty tone doesn't seem appropriate.READ more
28 Oct 2005 // 1:00 AM
Martin Scorsese's film is about Dylan's early life among the Mister Joneses of his era, ahead of rock and roll's learning curve and suffering the judgments of the slower kids in his class.READ more
28 Oct 2005 // 1:00 AM
In most cases, the performers are doing what they do best -- performing. And so they resist appearing too vulnerable.READ more
27 Oct 2005 // 1:00 AM
As Jack goes overboard in usual Ferrellian fashion, Isabel's insistence that he is the perfect mate for her go-normal plan never makes sense.READ more
27 Oct 2005 // 1:00 AM
'Based on a true story,' notes Amityville Horror producer Brad Fuller as the so-designating title rolls. 'Already controversial.'"READ more
25 Oct 2005 // 1:00 AM
In Melinda and Melinda, full of women struggling to make their desires known to men who suppose they know what women want and mean, the women are infinitely less regular and more interesting.READ more
24 Oct 2005 // 1:00 AM
Angela Robinson says the movie shows the 'scope and the joy of being a contender, more than winning, necessarily.' That Herbie allows this 'scope and joy' for a girl driver is mostly delightful.READ more
21 Oct 2005 // 1:00 AM
Rarely does a director's cut reflect a vision 'truer' to a source text. But, like most everything else surrounding the picture, The Outsiders: The Complete Novel is quite an anomaly.READ more
20 Oct 2005 // 1:00 AM
The documentary DVD explores every detail of production and Hill's vision, so that the film, for this writer becomes something altogether new.READ more
20 Oct 2005 // 1:00 AM
Diabolik and Eva rob from the old, snaggle-toothed, and ugly, as if their precarious self-esteem demands they humiliate those less genetically fortunate.READ more
18 Oct 2005 // 1:00 AM
The film doesn't cover up the difficulties of losing, even when showing the exultation of winning. All these kids, all their experiences, matter.READ more
18 Oct 2005 // 1:00 AM
The same lyrical invention that propels Face's narrative also serves as a stark lesson in the importance of solid plotting.READ more
Colette Carr "Static" (video) (Premiere) // Music
House of Blondes "First of July" (audio) (premiere) // Music
Digisaurus 'No More Room For Love' (EP stream) // Music
Eszter Balint 'Airless Midnight' (album stream) (premiere) // Music
PopMatters is on a short summer publishing break. We resume Monday, July 6th.
// Announcements
"PopMatters is on a short summer publishing break. We resume Monday, July 6th.READ the article


text:
"The world is a much more hopeful place because of the work and life of Lester Brown. World on the Edge should be read by everyone who wants to see a better life for their children, which is just about everybody." —Ted Glick, Policy Director of the Chesapeake Climate Action Network
Lester Brown Discusses Food Security on Bloomberg TV
March 10, 2014
Lester Brown appeared on Bloomberg Surveillance live with Tom Keene and Scarlet Fu to discuss how climate change and higher food costs are impacting the food industry.


text:
Microsoft Office Publisher 2007 For Dummies
For Dummies | 2007-12-26 | ISBN:0470184965 | PDF | 366 pages | 5 Mb
Microsoft Publisher 2007 For Dummies is a 50-75% revision to Microsoft Publisher 2000 For Dummies, covering both the Publisher 2003 and Publisher 2007 editions. The book focuses on three markets: Small and medium-sized businesses using Publisher for marketing campaigns; churches using Publisher to communicate via newsletters and marketing charity events; and schools using Publisher to communicate via newsletters and projects.
New features covered in the 2007 edition include:
Applying branding to materials
Searching for templates
Previewing templates
The Publisher Task pane
Storing and retrieving frequently used design elements
Personalizing e-mail with mail merge
Personalizing hyperlinks
Improving navigation with bookmarks
Combining lists within Publisher
Publishing in PDF or XPS format
Creating press-ready PDFs
Creating a new marketing campaign
Linking to Business Contacts for tracking
Searching folders
And more!
[Fast Download] Microsoft Office Publisher 2007 For Dummies
New Perspectives on Microsoft PowerPoint 2010, Comprehensive
Windows Home Server For Dummies
A Beginners Guide to Windows 8: The Unofficial Guide to Using Windows 8
Beginning Microsoft Word Business Documents
Getting Started with Windows Server Security
Access 2013 All-in-One For Dummies
Microsoft Word 2010 Inside Out
Excel 2007 For Dummies Quick Reference
Autonomic Computing: Concepts, Infrastructure, and Applications
Windows 7 Annoyances: Tips, Secrets, and Solutions
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.
|Windows Software
|Unix Software
|Mac Software
Excel PivotTables and PivotCharts: Your vi(3871)
Beginning Power Bi with Excel 2013(2392)
PowerPoint 2013 For Dummies by Doug Lowe(2013)
Windows 10: A Beginner's Guide(1872)
Microsoft Windows 7: Complete(1723)
Access 2013 All-in-One For Dummies(1703)
PowerPoint 2007 Graphics & Animation Made (1565)
Pro Office 365 Development (2nd edition)(1438)
Windows 7 Administrator's Pocket Consultan(1436)
How To Install Windows 7 from a USB Drive(1421)
Pro Excel Financial Modeling(1383)
Inside Windows 10 - A Buying Guide: Introd(1325)
Windows 8 All-in-One For Dummies(1319)
Microsoft Office 2010: Advanced(1303)
Microsoft Windows 7 Unleashed(1279)


text:
First Bank Kansas
SOUTH Santa Fe Ave 235,
Salina, KS 67401
(785) 825-2211
Business Details
YP Qualified
- Hours:
- Do you know the hours for this business?
- General Info:
- First Bank Kansas Has 9 Convenient ATM Locations Available to You: Salina 235 S Santa Fe (Drive-Up) 1333 W Crawford 2860 S 9th (Drive-Up)Kansas Wesleyan University (Cloud Street Entrance) K-State Salina, 2310 Centennial (College Center) McPherson 1301 N Main (Drive-Up) Ellsworth510 N Douglas 1420 Foster Abilene1410 N Buckeye (Drive-Up) First Bank Kansas is a unique, young, community bank with Midwest values. We began in Salina and grew into other communities. We currently have over $200 million in assets and employ approximately 85 people. You can expect to find the financial products you need and want at First Bank Kansas. We offer FREE checking and a FREE gift with every new checking account opened.First Bank Kansas has many checking accounts to choose from. Contact us today or visit our website and let us help you find the perfect account. At First Bank Kansas, when you open your FREE checking account you will also receive a FREE gift.
- Services/Products:
- Salina 235 S Santa Fe 67401 Ph: 785-825-2211; F: 785-825-7663 M - F Lobby: 9 AM - 4 PM; Drive-Thru: 7:30 AM - 5:30 PM Sat Drive-Thru Only: 8 AM - Noon ATM / Drive-Up ASSOCIATION * Member FDIC * Equal Housing LenderMasterCard,Star Cuccio,Star Building Systems,MasterCard
- Other Link:
- Categories:
- Banks, Financial Services


text:
Guests: Pat Healy, Ray Sefo, Tim Means and Sammy the Squid. Healy will be fighting next weekend at UFC 165. Means headlines tonight at Legacy FC 23. Sefo, the president of World Series of Fighting, will oversee WSOF 5 on Saturday. Squid gave Junkie Nation his college and pro picks for this weekend.
The Latest
RFA 27's Joe Murphy wants to tap more people than UFC's Tony Ferguson
You may have noticed this already, but UFC lightweight Tony Ferguson is an exceptional submission artist. RFA bantamweight Joe Murphy certainly has.
Must-see video with MMA elite ready for MMAjunkie Radio's 2,000th show
Next week in Las Vegas brings an event so big the entire MMA world is coming out for it. Don't miss the warriors coming out to play for MMAjunkie Radio show No. 2,000 in this insane video.
UFC exec: Changes may come to Reebok partnership – but not in compensation
A UFC exec says there may be changes to some parts of how the promotion's partnership with Reebok works – but don't expect those to come in the area of fighter compensation.
Uriah Hall booked for fight with Joe Riggs at UFC Fight Night 73 in Nashville
The UFC's return to "Music City" next month has a new fight added to the setlist with a middleweight bout between Uriah Hall and Joe Riggs.
Did Conor McGregor go too far hyping up his UFC 189 fight with Jose Aldo?
One of the most highly anticipated UFC bouts in years has fallen apart with Jose Aldo's injured rib forcing him out of the UFC 189 main event against Conor McGregor. But what do fellow UFC fighters think of McGregor's verbal antics in hyping the planned bout?
'UFC 189 Embedded,' No. 2: Mendes to Conor McGregor 'You're so tough, dude.'
Next week is arguably the UFC's biggest fight week of the year. And that means a jump start with "UFC 189 Embedded" and a preview of next week's pay-per-view event. Check out Episode No. 2 inside.
UFC strawweight champ Joanna Jedrzejczyk undergoes successful thumb surgery
Doctors flip-flopped over her medical status, but today UFC strawweight champion Joanna Jedrzejczyk finally went under the knife to repair damage on her injured thumb.


text:
i and my bf went second base and in the moment he actually saw my breasts and sucked on it and now it feels weird
shanon1989 16-17, F 10 Answers 1 Feb 12, 2014 in Dating & Relationships
Have him suck on the other one so they even out
Best Answer
If you feel weird about it, then it means you are too young to be doing that activity. It might be better to slow down. There is not good reason to have sex, especially when it doesn't feel right. Good luck.
Best Answer
its not that big a deal, just second ba<x>se.
Best Answer
If he sucked too hard and made a hickey or a bruise it could be sore for a while.
Best Answer
Maybe you weren't ready to go that far.
Best Answer
Youthful indiscretions happen, but think about why this didn't feel right before you go further.
Best Answer
welcome to the club :))
Best Answer
You'll be fine, breasts are gonna feel weird after a good sucking.
Best Answer
Your supposed to suck him in return. This is an unwelcome dishonor you've visited upon him. Most unwelcome.
Best Answer
Related Questions
I have actually felt genuinely upset for the first time. and now im actually sad. it feels weird to care.You level headed optimists are truly inspirations.
In dating-terms, for you, what is getting to first base? Second base? Third base? Home Run? and Grand Slam?1976toes 36-40, F 11 Answers 1 Aug 28, 2014 in Dating & Relationships
I do not understand the analogy...OtomeNoHeart 16-17, M 5 Answers 0 Sep 28, 2014 in Embarrassing & Funny
cougar1967 66-70, M 2 Answers 0 Apr 2 in Community
Why does my head hurt or feel weird almost everyday? My head often feels weird but incant explain how it feels!Why does my head always seem to hurt but in different ways. Somtimes when in the sun my temples hurt. Some days ot feels like the front of my head is being compressed some days it...FullOfEmpty 16-17, F 15 Answers 1 Aug 9, 2010
LikeMind 51-55, M 7 Answers 2 Feb 9, 2014 in Movies & TV
0zzy1 70+ 10 Answers 1 Mar 1 in Dating & Relationships
private parts in front of the mirror... oh my, did she think she was alone, it is a public washroom for all gym users... wow. I think she just got out of the shower and wanted to...Absolved 46-50, F 7 Answers 1 Mar 4, 2010
I'm so disappointed. I went to Walmart today and saw no one in their gown or pajamas. Saw no one talking to themself.Saw no one with a buggy piled full of nothing but beer. Saw no screaming kid. Saw no parent flogging a kid. Should I demand a refund?stankadiddlehopper 51-55, M 12 Answers 6 Jul 25, 2012


text:
Chiang Mai Street Food
Where to Eat and What to Try
For many people one of the most enduring memories of Thailand is seeing the bustling street side stands where mouth watering food is served up for less than the price of a cup of coffee. Street food is a charming aspect of life in Thailand and trying it out is a cultural and culinary delight.
Everywhere you go in Thailand you'll see the street vendors, preparing and serving a cornucopia of dishes from their simple carts and stalls. There's plenty of variety for the hungry browser; street carts usually specialize in one or two dishes but they usually clump together, providing excellent selection. Noodles, barbeque, curries and desserts, Thai street food is a pocket change smorgasbord.
{"detail":{"checkIn":"None","checkOut":"None","num_rooms":1,"num_adults":2,"num_children":0},"currency":null,"currencies":[{"code":"AUD","rate":"25.8015290807","name":"Australian Dollars","selected":false},{"code":"GBP","rate":"52.7405575943","name":"British Pounds","selected":false},{"code":"CAD","rate":"26.9309059653","name":"Canadian Dollars","selected":false},{"code":"CNY","rate":"5.4455715734","name":"Chinese Yuan Renminbi","selected":false},{"code":"DKK","rate":"5.0235542478","name":"Danish Kroner","selected":false},{"code":"EUR","rate":"37.4576768986","name":"Euro","selected":false},{"code":"HKD","rate":"4.3587358303","name":"Hong Kong Dollars","selected":false},{"code":"INR","rate":"0.5330384872","name":"Indian Rupee","selected":false},{"code":"IDR","rate":"0.0025405864","name":"Indonesian Rupiah","selected":false},{"code":"JPY","rate":"0.2745548911","name":"Japanese Yen","selected":false},{"code":"MYR","rate":"8.9682225428","name":"Malaysian Ringgit","selected":false},{"code":"MXN","rate":"2.1559322596","name":"Mexican Peso","selected":false},{"code":"NZD","rate":"22.7138209314","name":"New Zealand Dollars","selected":false},{"code":"RUB","rate":"0.6098667676","name":"Russian Ruble","selected":false},{"code":"SGD","rate":"25.0491567156","name":"Singapore Dollars","selected":false},{"code":"ZAR","rate":"2.7578519755","name":"South African Rand","selected":false},{"code":"KRW","rate":"0.0300953443","name":"South Korean Won","selected":false},{"code":"SEK","rate":"3.9958150933","name":"Swedish Kronor","selected":false},{"code":"CHF","rate":"35.8051669004","name":"Swiss Franc","selected":false},{"code":"THB","rate":"1.0000000000","name":"Thai Baht","selected":false},{"code":"USD","rate":"33.7877783895","name":"US Dollars","selected":false}],"skins":[],"results":[{"name":"Le Meridien Chiang Mai","id":"270166","hotel_id":"33323","description":"Located in Chang Moi, this luxury hotel is within 2 mi (3 km) of Chiang Mai Night Bazaar, Chiang Mai City Arts & Cultural Center, and Wat Chiang Man. Wiang Kum Kam and Warorot Market are also within 10 minutes. ","LongArea":"Chiang Mai","rating":"5.0","guest_rating":"4.4","image_url":"http:\/\/hotels.com\/hotels\/3000000\/2020000\/2019800\/2019747\/2019747_177_b.jpg","currency":"THB","price":"3723.75","tax_inclusive":"0","longitude":"98.99988","latitude":"18.78445","hc_url":"http:\/\/www.hotels.com\/ho270166","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/night-bazaar\/le-meridien-chiang-mai\/","distance_metres":null},{"name":"Shangri-La Hotel Chiang Mai","id":"261863","hotel_id":"25550","description":"Located in Chang Khlan, this luxury hotel is within 2 mi (3 km) of Central Chiang Mai Memorial Hospital, Chiang Mai City Arts & Cultural Center, and Wat Chiang Man. Chiang Mai Night Bazaar and Wiang Kum Kam are also within 15 minutes. ","LongArea":"Chiang Mai","rating":"5.0","guest_rating":"4.5","image_url":"http:\/\/hotels.com\/hotels\/2000000\/1810000\/1803100\/1803009\/1803009_25_b.jpg","currency":"THB","price":"4798.54","tax_inclusive":"0","longitude":"98.999406","latitude":"18.778403","hc_url":"http:\/\/www.hotels.com\/ho261863","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/riverside\/shangri_la-hotel-chiang-mai\/","distance_metres":null},{"name":"Siripanna Villa Resort & Spa Chiang Mai","id":"338988","hotel_id":"57199","description":"Located in the heart of Chiang Mai, this luxury resort is 0.5 mi (0.8 km) from Chiengmai Gymkhana Club and within 3 mi (5 km) of Chiang Mai City Arts & Cultural Center and Wat Chiang Man. Meng Memorial Bridge and Wiang Kum Kam are also within 2 mi (3 km). ","LongArea":"Chiang Mai","rating":"4.5","guest_rating":"4.5","image_url":"http:\/\/hotels.com\/hotels\/4000000\/3230000\/3226700\/3226656\/3226656_65_b.jpg","currency":"THB","price":"2926.35","tax_inclusive":"0","longitude":"99.015226","latitude":"18.774129","hc_url":"http:\/\/www.hotels.com\/ho338988","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/riverside\/siripanna-villa-resort-and-spa-chiang-mai\/","distance_metres":null},{"name":"dusitD2 Chiang Mai","id":"228275","hotel_id":"2606","description":"Located in Chang Moi, this luxury hotel is within 1 mi (2 km) of Chiang Mai Night Bazaar, Chiang Mai City Arts & Cultural Center, and Wat Chiang Man. Chiang Mai National Museum is 3 mi (4.8 km) away. ","LongArea":"Chiang Mai","rating":"4.5","guest_rating":"4.4","image_url":"http:\/\/hotels.com\/hotels\/2000000\/1190000\/1189700\/1189695\/1189695_34_b.jpg","currency":"THB","price":"2698.96","tax_inclusive":"0","longitude":"98.999738","latitude":"18.786082","hc_url":"http:\/\/www.hotels.com\/ho228275","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/night-bazaar\/dusitd2-chiang-mai\/","distance_metres":null},{"name":"The Imperial Mae Ping Hotel","id":"229930","hotel_id":"1175","description":"This family-friendly Chiang Mai hotel is located in the business district, within a 10-minute walk of Chiang Mai Night Bazaar and Wiang Kum Kam. Chiang Mai City Arts & Cultural Center and Wat Chiang Man are also within 2 mi (3 km). ","LongArea":"Chiang Mai","rating":"4.0","guest_rating":"3.8","image_url":"http:\/\/hotels.com\/hotels\/2000000\/1160000\/1156500\/1156493\/1156493_181_b.jpg","currency":"THB","price":"1184.26","tax_inclusive":"0","longitude":"98.998371","latitude":"18.783172","hc_url":"http:\/\/www.hotels.com\/ho229930","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/night-bazaar\/imperial-mae-ping-hotel\/","distance_metres":null},{"name":"RarinJinda Wellness Spa Resort","id":"260823","hotel_id":"14028","description":"Located in Charoenmuang, this luxury resort is within 2 mi (3 km) of Wat Gatekaram, Chiang Mai City Arts & Cultural Center, and Wat Chiang Man. Chiang Mai National Museum is 3.1 mi (4.9 km) away. ","LongArea":"Chiang Mai","rating":"4.5","guest_rating":"4.5","image_url":"http:\/\/hotels.com\/hotels\/2000000\/1790000\/1788800\/1788757\/1788757_38_b.jpg","currency":"THB","price":"3199.70","tax_inclusive":"0","longitude":"99.004234","latitude":"18.789566","hc_url":"http:\/\/www.hotels.com\/ho260823","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/riverside\/rarinjinda-wellness-spa-resort\/","distance_metres":null},{"name":"Royal Panerai Hotel","id":"410000","hotel_id":"67372","description":"Located in Chang Moi, this hotel is within 1 mi (2 km) of Chang Puak Market, Chiang Mai City Arts & Cultural Center, and Wat Chiang Man. Chiang Mai National Museum is 2.2 mi (3.5 km) away. ","LongArea":"Chiang Mai","rating":"3.0","guest_rating":"3.8","image_url":"http:\/\/hotels.com\/hotels\/6000000\/5150000\/5146000\/5145939\/5145939_19_b.jpg","currency":"THB","price":"402.41","tax_inclusive":"0","longitude":"98.994077","latitude":"18.79645","hc_url":"http:\/\/www.hotels.com\/ho410000","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/chang-phuak\/royal-panerai-hotel-chiangmai\/","distance_metres":null},{"name":"Rachamankha","id":"254900","hotel_id":"1737","description":"Located in Old City, this luxury hotel is within a 15-minute walk of Wat Phra Singh and Chiang Mai City Arts & Cultural Center. Chiang Mai National Museum and Wat Chiang Man are also within 3 mi (5 km). ","LongArea":"Chiang Mai","rating":"5.0","guest_rating":"4.8","image_url":"http:\/\/hotels.com\/hotels\/2000000\/1100000\/1099700\/1099622\/1099622_44_b.jpg","currency":"THB","price":"5070.53","tax_inclusive":"0","longitude":"98.98032","latitude":"18.787205","hc_url":"http:\/\/www.hotels.com\/ho254900","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/chiang-mai-old-city\/rachamankha-_-a-member-of-secret-retreats\/","distance_metres":null},{"name":"Chiang Mai Plaza Hotel","id":"279346","hotel_id":"1170","description":"Located in Chang Khlan, this aparthotel is within 2 mi (3 km) of Chiang Mai Night Bazaar, Chiang Mai City Arts & Cultural Center, and Wat Chiang Man. Wiang Kum Kam and Central Chiang Mai Memorial Hospital are also within 15 minutes. ","LongArea":"Chiang Mai","rating":"4.0","guest_rating":"3.7","image_url":"http:\/\/hotels.com\/hotels\/2000000\/1710000\/1710000\/1709913\/1709913_41_b.jpg","currency":"THB","price":"978.15","tax_inclusive":"0","longitude":"98.999899","latitude":"18.781806","hc_url":"http:\/\/www.hotels.com\/ho279346","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/night-bazaar\/chiang-mai-plaza-hotel\/","distance_metres":null},{"name":"137 Pillars House","id":"395631","hotel_id":"65725","description":"Located in the heart of Chiang Mai, this luxury hotel is within 2 mi (3 km) of Wat Gatekaram, Chiang Mai City Arts & Cultural Center, and Wat Chiang Man. Chiang Mai National Museum is 3 mi (4.9 km) away. ","LongArea":"Chiang Mai","rating":"5.0","guest_rating":"4.8","image_url":"http:\/\/hotels.com\/hotels\/5000000\/4720000\/4715700\/4715680\/4715680_84_b.jpg","currency":"THB","price":"8999.71","tax_inclusive":"0","longitude":"99.004098","latitude":"18.792131","hc_url":"http:\/\/www.hotels.com\/ho395631","promo":"","url":"http:\/\/www.asiawebdirect.com\/thailand\/chiang-mai\/riverside\/137-pillars-house\/","distance_metres":null}],"accomList":[],"facilities":[],"ServicePercent":0,"show_header":0,"expectedHotels":10,"pageSize":50,"hasNext":false,"hasPrev":false,"sortBy":"byPopularity"}
Street Food in Chiang Mai
For many people one of the most enduring memories of Thailand is seeing the bustling street side stands where mouth watering food is served up for less than the price of a cup of coffee. Street food is a charming aspect of life in Thailand and trying it out is a cultural and culinary delight.
Everywhere you go in Thailand you'll see the street vendors, preparing and serving a cornucopia of dishes from their simple carts and stalls. Some vendors have mobile carts ranging from baskets balanced on the shoulders to motorbikes welded to portable kitchens. These vendors usually have a set route that they travel throughout the day and Thais often anticipate their arrival like a daily visit from Santa Claus. When a popular vendor comes down the street don't be surprised to Thais pouring onto the street like clowns out of a Volkswagen to get a quick bite of their favourite treats.
Some street food vendors have more permanent set ups, often in front of busy places like convenience stores. These stalls are somewhere between a restaurant and a food cart and are semi permanent. Often a large group of vendors will set up shop along one area, each offering a different item. It's perfectly acceptable to bring food from one cart and sit down at another cart's table, provided someone in your party is buying something.
What to Eat
There's plenty of variety for the hungry browser; street carts usually specialize in one or two dishes but they usually clump together, providing excellent selection. Noodle soup with chicken or pork is the standard and stalls can be found anywhere, any time. Noodle soup is not a simple as it sounds. It can actually be one of the most complex things you can order: there are egg noodles, thin and fat rice noodles, different kinds of meat and a variety of meat balls, as well as sprouts and leafy vegetables. On top of that there are at least four condiments. Every bowl of noodle soup is different and it's fun to experiment with the different combinations until you hit on your favourite.
Barbeque is the staple of the Issan (north-eastern) region of Thailand and Issan food has made its way to the streets of every town in Thailand. Everywhere you go, you'll be tempted by the aroma of juicy chicken and pork sizzling over a charcoal fire. Barbeque is usually eaten with kaao nieow (sticky rice), moulded into balls with the hands. Top it off with some Som Tam (spicy shredded papaya salad) and you've got the classic Thai lunch. Fried chicken is also popular and is pretty much the same the world over. For the best fried chicken find a Muslim cart, easily identifiable from the star and crescent moon symbol. Muslims don't eat pork and beef is not eaten too much in Thai cooking so the Muslims have mastered the art of chicken.
Make sure to get some fried garlic to go with your sticky rice. Many street carts have tins up front with a variety of curry and noodles dishes. These are worth a try but bring your asbestos tongue - these are usually the spiciest dishes. If you're a little unsure feel free to ask the proprietor which ones to avoid. If you want to take a curry to go, just pop it in a plastic bag, along with your rice and all your sauces - Thai sack lunch!
Most Thais have a sweet tooth and so there are always desserts and other treats around. One of the most visible and delicious is Roti, a Thai take on a classic Muslim dish. Thai roti is very thin and comes with egg, banana, sugar, condensed milk and chocolate for a perfect after noodle snack. Other Thai desserts are made from pounded coconut or rice and flavoured with fruit. The quintessential Chiang Mai dessert is sticky rice with mango and condensed milk, which also makes for a satisfying breakfast.
Where to Go
While street food is everywhere you look, there are certainly some areas where vendors flock in especially high numbers and these are worth mentioning. Along Moon Muang Road north of Tha Phae Gate you'll find the Somphet Market. This lively area is a great place to shop for fresh ingredients and many cooking classes take their students here on a 'mini field trip' to learn about the building blocks of Thai food. There are vendors located here nearly 24 hours a day, coming and going almost in shifts. In the wee hours of the morning this is a good place to come and get fresh sausage - including a deep fried version of naem (hand rolled fermented pork) you might not see anywhere else. As the day wears on this becomes a great place to find fresh fruit, while the barbeque contingent starts to appear at about midday. Once the sun goes down noodle stands start appearing like fireflies, interspersed with some great roti vendors.
Another popular area for informal al fresco dining (read: chowing down kerbside) is the Chiang Mai Gate Market, located (you guessed it) near Chiang Mai Gate at the southwest corner of the moat. Another good spot to pick up fresh ingredients, this is a treasure trove of roadside goodies starting at around sunset. A huge variety of stalls crowd together on either side of the street with plenty of seating on the moat side of the road. This is a perfect place to be adventurous and try one of a kind dishes you might never see elsewhere. Take a little bit of everything, camp out at one of the small tables and spend some time sampling.
The cuisine at the street stalls is some of the best you'll find anywhere. Vendors often prepare only one dish day after day and they become black belts at it. Locals get to know which carts have the best food and will travel for miles just to find the best vendors. Street food is a part of the everyday life of nearly all Thais and don't be surprised to see bankers and doctors tucking in side by side with labourers and store clerks.


text:
Two Men Threatened With Ticket In Driveway [VIDEO]
Well, how ridiculous is this? I'd be quite the criminal if this was a law in Erie County. I wash my car A LOT, and apparently, it's against the law in Garden City, N.Y.
Well, how ridiculous is this? I'd be quite the criminal if this was a law in Erie County. I wash my car A LOT, and apparently, it's against the law in Garden City, N.Y.
No one likes a clingy person.
Especially the police.
This driver ought to seriously think about getting a bus pass.
Whether you agree with law enforcement or not, it's the law, and you would think everyone would respect that.
You can bet this guy's gonna fry for what he did.
Around 9:20 a.m. this morning, police received a call about a domestic dispute, house fire and active shooter situation on Fries Road in Tonawanda. The incident caused the closure of schools and some streets.
There's always some less-than-thrilling things that happen each week, whether it's across the country, down to Music City in Nashville, or right here in our WNY backyards.
A woman in Chicago who was nearly three times the legal limit was arrested for DUI. She was brought to the station, where was she patted down. Important note: By a woman, she was patted down. After she became uncooperative and after kicking officers, they carried the 33 year old to a different holding center, where she was than stripped out of her clothes.
Police officers in Florida face investigation over injuries to DUI suspect in August arrest
People are mad about this. A cop, while on duty, decided to show some kids at a bike park exactly how it's done.
If only I had this good deed happen to me for one of my 49 parking tickets during my tenure at UB. Than again...what does one ticket make a difference when you have 49 of them?
I went on a rampage tonight on YouTube and found quite a string of hilarious and interesting videos. I decided to give you my favorite YouTube clips of 2013 (so far).


text:
Sorry guys for not updating in awhile, but I have been really busy with my move and alot of other stuff in my personal life. That's gonna change now, I have started by updating some photoshoot albums with new pictures. Its to bad they are all tagged, but it's better than nothing, right? Adds have been added to the photoshoot albums, Entertainment Weekly and LA Confidential, both from 2008. Stay tuned for more fun updates! Visit Introducing Jessica Stroup.
Do not forget to watch the new episode of 90210 tonight, finally!


text:
Ask mom for the wireless password. :)
Foursquare © 2015 Lovingly made in NYC & SF
Taco Time
Mexican · $
18029 68th Ave NE
"FUN THING TO DO: Pretend your Crisp Burrito is a magic wand, and then imagine that you can conjure Mexi-Fries from the ether."
Coffee Shop · $$
7750 NE Bothell Way
"Hot drinks, cold drinks, snacks, free wi-fi and plenty of space to sit while you hang out. What more do you need? Enjoy!"
Espresso Works
Coffee Shop · $
6524 NE 181st St
"The dark chocolate caramel mocha is the bomb - not on the menu. Get it!"
Make sure your information is up to date. Plus use our free tools to find new customers.
Download Foursquare for your smart phone and start exploring the world around you!


text:
1995 Suzuki Sidekick Q&A
1995 Suzuki Sidekick Question: Where are the switches located that allows the auto to start when the clutch ped
pedal is depressed. Should it start if the pedal is on the floor and the cable is not connected? Switches on pedal are all working. Anything else in line? Fuel pump runs but starter won't spin. Happened when weld broke on clutch pedal. - heilco
Answer 1
no you have to depress switch under dash by clutch peadl. do not use car without this operational - globalhelper
Related Content
1. pushrod
2. stevieray1
3. globalhelper
4. Shivers
5. csubak30
6. ziptie12
7. Hal...
8. IsraelS
9. goodguy
10. BrianLankford


text:
7-Day Forecast
Canadensis, PA 18325
Weather News
Other Top Weather Headlines
Big Thunderstorms Take Aim at Ohio Valley, Southeast
The Upper Midwest and Ohio Valley haven't been strangers to severe weather lately, and today won't be any different. Large…More >
Washington State Wildfire Destroys Homes as Hundreds Flee
A wildfire fueled by high temperatures destroyed residences in Washington…More >
June Will Feature a 'Leap Second'... Should You Be Scared?
The last day of June will have a leap second added. What does this…More >
WeatherBug Featured Content
Green Living
You too can help save our planet and put money back in your wallet. Learn how you can take the first steps to reduce your environmental impact, including driving green, easy ways you can conserve water, and energy saving tips. To learn more and discover the benefits of going green, visit WeatherBug's green living section. More >
Sponsored Content
Be Prepared, Know Before
Get faster alerts and better forecasts from the exclusive neighborhood-level WeatherBug network.Learn More
Seven Day Forecast Near Canadensis, PA
- Mount Pocono Seven Day Forecast
- Stroudsburg Seven Day Forecast
- Lake Ariel Seven Day Forecast
- Scranton Seven Day Forecast
- Honesdale Seven Day Forecast
- Throop Seven Day Forecast
- Brodheadsville Seven Day Forecast
- Dingmans Ferry Seven Day Forecast
- Montague Seven Day Forecast
- Kunkletown Seven Day Forecast


text:
Are you Christopher G Wood?Claim your profile
Publications (271)1446.17 Total impact
Article: Variability of Inter-observer Agreement on Feasibility of Partial Nephrectomy Before and After Neoadjuvant Axitinib for Locally Advanced RCC: Independent Analysis from a Phase II Trial[Show abstract] [Hide abstract]
ABSTRACT: Objective To evaluate how many patients could have undergone PN instead of RN before and after neoadjuvant axitinib therapy, as assessed by 5 independent urologic oncologists, and to study the variability of inter-observer agreement.Patients and Methods Pre- and post systemic treatment CT scans from 22 patients with ccRCC in a phase II neoadjuvant axitinib trial were reviewed by 5 independent urologic oncologists. RENAL score and Kappa statistics were calculated.ResultsMedian RENAL score changed from 11 pre-treatment to 10 post-treatment, p=0.0017. Five tumors with moderate-complexity pre-treatment remained moderate-complexity post-treatment. Of 17 tumors with high-complexity pre-treatment, 3 became moderate-complexity post-treatment. Overall kappa statistic was 0.611. Moderate-complexity kappa was 0.611 vs. high-complexity kappa of 0.428. Pre-treatment kappa was 0.550 vs. post-treatment of 0.609. After treatment with axitinib, all 5 reviewers agreed that only 5 patients required RN (instead of 8 pre-treatment) and that 10 patients could now undergo PN (instead of 3 pre-treatment). The odds of PN feasibility were 22.8-times higher after treatment with axitinib.Conclusions There is considerable variability in inter-observer agreement on the feasibility of PN in patients treated with neoadjuvant targeted therapy. Although more patients were candidates for PN after neoadjuvant therapy, it remains difficult to identify these patients a priori.This article is protected by copyright. All rights reserved.BJU International 06/2015; DOI:10.1111/bju.13188 · 3.13 Impact Factor
Article: Metastases to the Kidney: A Comprehensive Analysis of 151 Patients from a Tertiary Referral Center[Show abstract] [Hide abstract]
ABSTRACT: PurposeMetastases to the kidney are a rare entity, historically described in autopsy studies. The primary aim of this study was to describe the presentation, treatment, and outcomes of patients with metastatic tumors to the kidney treated at a tertiary referral center.Patients and Methods We retrospectively identified 151 patients diagnosed with a primary non-renal malignancy with renal metastasis. Clinical, radiographic and pathologic characteristics were assessed. Overall survival (OS) was calculated using Kaplan-Meier methods.ResultsMedian patient age was 56.7 years. The most common presenting symptoms were flank pain (30%), hematuria (16%) and weight loss (12%). Most primary cancers were carcinomas (80.8%). The most common primary tumor sites were lung (43.7%), colorectal (10.6%), ENT (6%), breast (5.3%), soft tissue (5.3%), and thyroid (5.3%). Renal metastases were typically solitary (77.5%). Concordance between radiologist and clinician imaging assessment was 54.0%. Three ablations and 48 nephrectomies were performed. For non-surgical patients, renal metastasis diagnosis was made with FNA or biopsy. Median OS from primary tumor diagnosis was 3.08 years and median OS from time of metastatic diagnosis was 1.13 years. For patients treated with surgery, median OS from primary tumor diagnosis was 4.81 years, and OS from metastatic diagnosis was 2.24 years.Conclusions Metastases to the kidney are a rare entity. Survival appears to be longer in patients who are candidates for, and are treated with surgery. Surgical intervention in carefully selected patients with oligometastatic disease and good performance status should be considered. A multi-disciplinary approach with input from urologists, oncologists, radiologists, and pathologists is needed to achieve the most optimal outcomes for this specific patient population.This article is protected by copyright. All rights reserved.BJU International 06/2015; DOI:10.1111/bju.13194 · 3.13 Impact Factor
Article: Percentage of sarcomatoid component as a prognostic indicator for survival in renal cell carcinoma with sarcomatoid dedifferentiation.[Show abstract] [Hide abstract]
ABSTRACT: Renal cell carcinoma with sarcomatoid dedifferentiation (sRCC) is associated with higher stage of presentation and worse survival. The objective of this study was to examine the clinicopathologic characteristics associated with overall survival (OS), specifically examining the percentage of sarcomatoid component (PSC). We reviewed clinicopathologic data for all nephrectomized patients with confirmed sRCC. Histologic slides were rereviewed by dedicated genitourinary pathologists to ascertain PSC. Patient characteristics were tabulated overall and by disease stage. Cutpoints in the PSC providing a meaningful difference in OS were identified by recursive partitioning analysis (RPA). Factors selected included age group, gender, race, clinical stage, tumor histology, presurgical systemic therapy, lymphovascular invasion, and tumor size. The Kaplan-Meier method and log-rank test were used to assess differences in OS. Among 186 patients with sRCC, 64 (34%) had localized, and 122 (66%) had metastatic disease at presentation. Patients had primarily clear cell histology (73%). Median follow-up was 12.1 months (range: 0.1-242.2mo). Median OS was 12.6 months (95% CI: 10.7-14.9mo). Univariate RPA identified a PSC cutpoint of 10% as prognostically significant. Patients with PSC>10% were at higher risk of death when compared with patients with PSC≤10% (45% vs. 61% 1-y OS; P = 0.04). Multivariate RPA revealed that tumor size, presence of metastatic disease, and PSC were significantly associated with OS. Among 4 identified groups, patients with localized disease and tumor size≤10cm were most likely to be alive at 1 year (89%), and patients with metastatic disease and PSC>40% were least likely to be alive at 1 year (28%; P<0.001). PSC appears to be a prognostic factor in patients with sRCC, with larger percentage of involvement portending a worse survival, especially in patients with metastatic disease. Copyright © 2015 Elsevier Inc. All rights reserved.Urologic Oncology 05/2015; DOI:10.1016/j.urolonc.2015.04.011 · 3.36 Impact Factor
Article: Effects of adjuvant sorafenib and sunitinib on cardiac function in renal cell carcinoma patients without overt metastases:results from ASSURE, ECOG2805[Show abstract] [Hide abstract]
ABSTRACT: Sunitinib and sorafenib are used widely in the treatment of renal cell carcinoma (RCC). These agents are associated with a significant incidence of cardiovascular (CV) dysfunction and left ventricular ejection fraction (LVEF) declines, observed largely in the metastatic setting. However, in the adjuvant population, the CV effects of these agents remain unknown. We prospectively defined the incidence of cardiotoxicity amongst resected, high-risk RCC patients treated with these agents. Sunitinib, sorafenib, or placebo was administered for up to 12 months in patients with high-risk, resected RCC. LVEF was measured by multi-gated acquisition (MUGA) scans at standard intervals. Additional CV adverse events were reported according to NCI Common Terminology Criteria for Adverse Events (CTCAE). Among 1,943 patients randomized, 1,599 had at least 1 post-baseline MUGA. Within 6 months, 21 patients (1.3%) experienced a cardiac event, defined as an LVEF decline from baseline that was >15% and below the institutional lower limit of normal. Nine of 513 (1.8%) patients were on sunitinib; 7 of 508 (1.4%) on sorafenib; and 5 of 578 (0.9%) on placebo (p=0.28 and 0.56 comparing sunitinib and sorafenib to placebo, respectively). With dose interruption or adjustment, 16 of the 21 recovered their LVEF to >50%. The incidence of symptomatic heart failure, arrhythmia, or myocardial ischemia did not differ among groups. In the adjuvant setting, we prospectively define low incidence of cardiotoxicity with sunitinib and sorafenib. These findings may be related to close CV monitoring, or potentially to fewer CV comorbidities in our non-metastatic population. Copyright © 2015, American Association for Cancer Research.Clinical Cancer Research 05/2015; DOI:10.1158/1078-0432.CCR-15-0215 · 8.19 Impact Factor
Article: Biphasic Components of Sarcomatoid Clear Cell Renal Cell Carcinomas Are Molecularly Similar but Distinct from Non-Sarcomatoid Renal Carcinomas[Show abstract] [Hide abstract]
ABSTRACT: Sarcomatoid transformation, wherein an epithelioid carcinomatous tumour component coexists with a sarcomatoid histology, is a predictor of poor prognosis in clear cell renal cell carcinoma (ccRCC). Our understanding of sarcomatoid change has been hindered by the lack of molecular examination. Thus, we sought to characterize molecularly the biphasic epithelioid and sarcomatoid components of sarcomatoid ccRCC and compare them to non-sarcomatoid ccRCC. We examined the transcriptome of the epithelioid and sarcomatoid components of advanced stage sarcomatoid ccRCC (n=43) and non-sarcomatoid ccRCC (n=37) from independent discovery and validation cohorts using the cDNA microarray and RNA-seq platforms. We analyzed DNA copy number profiles, generated using SNP arrays, from patients with sarcomatoid ccRCC (n=10) and advanced non-sarcomatoid ccRCC (n=155). The epithelioid and sarcomatoid components of sarcomatoid ccRCC had similar gene expression and DNA copy number signatures that were, however, distinct from those of high-grade, high-stage non-sarcomatoid ccRCC. Prognostic ccRCC gene expression profiles were shared by the biphasic components of sarcomatoid ccRCC and the sarcomatoid component showed a partial epithelial-to-mesenchymal transition signature. Our genome-scale microarray-based transcript data were validated in an independent set of sarcomatoid and non-sarcomatoid ccRCCs using RNA-seq. Sarcomatoid ccRCC is molecularly distinct from non-sarcomatoid ccRCC, with its genetic programming largely shared by its biphasic morphological components. These data explain why a low percentage of sarcomatoid histology augurs a poor prognosis; suggest the need to modify the pathological grading system; and introduce the potential for candidate biomarkers to detect sarcomatoid change preoperatively without specifically sampling the S component. This article is protected by copyright. All rights reserved.05/2015; DOI:10.1002/cjp2.23
Article: A Literature Review of Renal Surgical Anatomy and Surgical Strategies for Partial Nephrectomy[Show abstract] [Hide abstract]
ABSTRACT: A detailed understanding of renal surgical anatomy is necessary to optimize preoperative planning and operative technique and provide a basis for improved outcomes. To evaluate the literature regarding pertinent surgical anatomy of the kidney and related structures, nephrometry scoring systems, and current surgical strategies for partial nephrectomy (PN). A literature review was conducted. Surgical renal anatomy fundamentally impacts PN surgery. The renal artery divides into anterior and posterior divisions, from which approximately five segmental terminal arteries originate. The renal veins are not terminal. Variations in the vascular and lymphatic channels are common; thus, concurrent lymphadenectomy is not routinely indicated during PN for cT1 renal masses in the setting of clinically negative lymph nodes. Renal-protocol contrast-enhanced computed tomography or magnetic resonance imaging is used for standard imaging. Anatomy-based nephrometry scoring systems allow standardized academic reporting of tumor characteristics and predict PN outcomes (complications, remnant function, possibly histology). Anatomy-based novel surgical approaches may reduce ischemic time during PN; these include early unclamping, segmental clamping, tumor-specific clamping (zero ischemia), and unclamped PN. Cancer cure after PN relies on complete resection, which can be achieved by thin margins. Post-PN renal function is impacted by kidney quality, remnant quantity, and ischemia type and duration. Surgical renal anatomy underpins imaging, nephrometry scoring systems, and vascular control techniques that reduce global renal ischemia and may impact post-PN function. A contemporary ideal PN excises the tumor with a thin negative margin, delicately secures the tumor bed to maximize vascularized remnant parenchyma, and minimizes global ischemia to the renal remnant with minimal complications. In this report we review renal surgical anatomy. Renal mass imaging allows detailed delineation of the anatomy and vasculature and permits nephrometry scoring, and thus precise, patient-specific surgical planning. Novel off-clamp techniques have been developed that may lead to improved outcomes. Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.European Urology 04/2015; DOI:10.1016/j.eururo.2015.04.010 · 12.48 Impact Factor
Article: PD35-05 MULTICENTER VALIDATION OF PREDICTIVE MODEL FOR POSTSURGICAL RECURRENCE IN NON-METASTATIC RCC WITH THROMBUSThe Journal of Urology 04/2015; 193(4):e761. DOI:10.1016/j.juro.2015.02.2228 · 3.75 Impact Factor
Article: Preoperative multivariable prognostic models for prediction of survival and major complications following surgical resection of renal cell carcinoma with suprahepatic caval tumor thrombus.[Show abstract] [Hide abstract]
ABSTRACT: Surgical resection for renal cell carcinoma (RCC) with suprahepatic inferior vena cava tumor thrombus is associated with significant morbidity, yet there are currently no tools for preoperative prognostic evaluation. Our goal was to develop a preoperative multivariable model for prediction of survival and risk of major complications in patients with suprahepatic thrombi. We identified patients who underwent surgery for RCC with suprahepatic tumor thrombus extension from 2000 to 2013 at 4 tertiary centers. A Cox proportional hazard model was used for analysis of overall survival (OS) and logistic regression was used for major complications within 90 days of surgery (Clavien≥3A). Nomograms were internally calibrated by bootstrap resampling method. A total of 49 patients with level III thrombus and 83 patients with level IV thrombus were identified. During median follow-up of 24.5 months, 80 patients (60.6%) died and 46 patients (34.8%) experienced major complication. Independent prognostic factors for OS included distant metastases at presentation (hazard ratio = 2.52, P = 0.002) and Eastern Cooperative Oncology Group (ECOG) performance status (hazard ratio = 1.84, P<0.0001). Variables associated with increased risk of major complications on univariate analysis included preoperative systemic symptoms, level IV thrombus, and elevated preoperative alkaline phosphatase and aspartate transaminase levels; however, only systemic symptoms (odds ratio = 8.45, P<0.0001) was an independent prognostic factor. Preoperative nomograms achieved a concordance index of 0.72 for OS and 0.83 for major complications. We have developed and internally validated multivariable preoperative models for the prediction of survival and major complications in patients with RCC who have a suprahepatic inferior vena cava thrombus. If externally validated, these tools may aid in patient selection for surgical intervention. Copyright © 2015 Elsevier Inc. All rights reserved.Urologic Oncology 04/2015; 193(4):e763-e764. DOI:10.1016/j.juro.2015.02.2234 · 3.36 Impact Factor
Article: Surgical Management for Local Retroperitoneal Recurrence Of Renal Cell Carcinoma After Radical Nephrectomy[Show abstract] [Hide abstract]
ABSTRACT: Isolated local retroperitoneal recurrence (RPR) after radical nephrectomy (RN) for renal cell carcinoma (RCC) poses a therapeutic challenge. We investigated the outcomes of patients with localized RPR treated with surgical resection. This was a retrospective single-institutional study of 102 patients with RPR treated with surgery from 1990-2014. Demographics, clinical and pathological features, location of RPR, perioperative complications were reported using descriptive statistics. Recurrence free survival (RFS) and cancer-specific survival (CSS) were studied using univariate and multivariate analyses. Median age at RPR diagnosis was 55 years (IQR 49-64). Sixty-two (60.8%) patients were pT3-4 and 20 (19.6%) were pN1. No patients had distant metastatic disease at time of RPR surgery. Median time from nephrectomy to RPR diagnosis was 19 months (IQR 5-38.8). The median size of resected RPR was 4.5cm (IQR 2.7-7). Median follow up after RPR surgery was 32 months (IQR 16-57). Metastatic progression was observed in 60 (58.8%) patients after RPR surgery. Neoadjuvant and salvage systemic therapy were administered in 46 (45.1%) and 48 (47.1%) patients, respectively. On multivariate analysis, pathological nodal stage at original nephrectomy and maximum diameter of RPR were identified as independent risk factors for cancer specific death. Clinico-pathological factors at the time of nephrectomy as well as RPR surgery are important prognosticators. Aggressive surgical resection offers potential cure in a substantial number of patients with RPR with acceptable complications, and still plays a dominant role in the management of isolated locally recurrent RCC. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.The Journal of Urology 03/2015; 193(4). DOI:10.1016/j.juro.2015.02.2943 · 3.75 Impact Factor
Article: Multilevel-analysis identify a cis-expression quantitative trait locus associated with risk of renal cell carcinoma.[Show abstract] [Hide abstract]
ABSTRACT: We conducted multilevel analyses to identify potential susceptibility loci for renal cell carcinoma (RCC), which may be overlooked in traditional genome-wide association studies (GWAS). A gene set enrichment analysis was performed utilizing a GWAS dataset comprised of 894 RCC cases and 1,516 controls using GenGen, SNP ratio test, and ALIGATOR. The antigen processing and presentation pathway was consistently significant (P = 0.001, = 0.004, and < 0.001, respectively). Versatile gene-based association study approach was applied to the top-ranked pathway and identified the driven genes. By comparing the expression of the genes in RCC tumor and adjacent normal tissues, we observed significant overexpression of HLA genes in tumor tissues, which was also supported by public databases. We sought to validate genetic variants in antigen processing and presentation pathway in an independent GWAS dataset comprised of 1,311 RCC cases and 3,424 control subjects from the National Cancer Institute; one SNP, rs1063355, was significant in both populations (Pmeta-analysis = 9.15 × 10-4, Pheterogeneity = 0.427). Strong correlation indicated that rs1063355 was a cis-expression quantitative trait loci which associated with HLA-DQB1 expression (Spearman's rank r = -0.59, p = 5.61 × 10-6). The correlation was further validated using a public dataset. Our results highlighted the role of immune-related pathway and genes in the etiology of RCC.Oncotarget 02/2015; 6(6):4097-109. · 6.63 Impact Factor
Article: Clinically nonmetastatic renal cell carcinoma with sarcomatoid dedifferentiation: Natural history and outcomes after surgical resection with curative intent[Show abstract] [Hide abstract]
ABSTRACT: Renal cell carcinoma with sarcomatoid dedifferentiation (sRCC) is an aggressive malignancy associated with a poor prognosis. Although existing literature focuses on patients presenting with metastatic disease, characteristics and outcomes for patients with localized disease are not well described. We aimed to evaluate postnephrectomy characteristics, outcomes, and predictors of survival in patients with sRCC who presented with clinically localized disease. An institutional review board-approved review from 1986 to 2011 identified 77 patients who presented with clinically localized disease, underwent nephrectomy, and had sRCC in their primary kidney tumor. Clinical and pathologic variables were captured for each patient. Overall survival (OS) and recurrence-free survival (RFS) were calculated for all patients and those who had no evidence of disease (NED) following nephrectomy, respectively. Comparisons were made with categorical groupings in proportional hazards regression models for univariable and multivariable analyses. OS for the entire cohort (n = 77) at 2 years was 50%. A total of 56 (77%) patients of the 73 who has NED following nephrectomy experienced a recurrence, with a median time to recurrence of 26.2 months. On multivariable analysis, tumor stage, pathologically positive lymph nodes, and year of nephrectomy were significant predictors of both OS and recurrence-free survival. Limitations include the retrospective nature of this study and relatively small sample size. Long-term survival for patients with sRCC, even in clinically localized disease, is poor. Aggressive surveillance of those who have NED following nephrectomy is essential, and further prospective studies evaluating the benefit of adjuvant systemic therapies in this cohort are warranted. Copyright © 2014 Elsevier Inc. All rights reserved.Urologic Oncology 02/2015; 33(4). DOI:10.1016/j.urolonc.2014.11.021 · 3.36 Impact Factor
Conference Paper: Resistance to anti-angiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Renal cell carcinoma (RCC) is an immunogenic and proangiogenic cancer, and anti-angiogenic therapy is the current mainstay of treatment. RCC patients develop innate or adaptive resistance to anti-angiogenic therapy. There is a need to identify biomarkers which predict therapeutic resistance and guide combination therapy. We assessed the interaction between anti-angiogenic therapy and tumor immune microenvironment, and determined their impact on clinical outcome. Here we found that anti-angiogenic therapy treated RCC primary tumors demonstrated increased infiltration of CD4+ and CD8+ T lymphocytes, which was inversely related to patient overall survival (OS) and progression free survival (PFS). Furthermore, anti-angiogenic therapy treated specimens showed higher infiltration of CD4+FOXP3+ regulatory T cells (Tregs) and enhanced expression of checkpoint ligand programed death-ligand 1 (PD-L1). Both immunosuppressive features were correlated with T lymphocyte infiltration and were negatively related to patient survival. Treatment of RCC cell lines and RCC xenografts in immunodeficient mice with sunitinib also increased tumor PD-L1 expression. This study indicates that anti-angiogenic treatment may both positively and negatively regulate the tumor immune microenvironment. These findings generate hypotheses on resistance mechanisms to anti-angiogenic therapy, and will guide the development of combination therapy with PD-1/PD-L1 blocking agents. Copyright © 2015, American Association for Cancer Research.2015 Genitourinary Cancers Symposium of the American Society of Clinical Oncology, J Clin Oncol 33, 2015 (suppl 7; abstr 419); 02/2015
Article: Mitochondrial DNA Copy Number in Peripheral Blood Leukocytes and the Risk of Clear Cell Renal Cell Carcinoma.[Show abstract] [Hide abstract]
ABSTRACT: Variation of mitochondrial DNA copy number (mtDNAcn) in peripheral blood leukocytes (PBLs) has been associated with the risk of various cancers, including renal cell carcinoma (RCC). We assessed the association between mtDNAcn and clear cell RCC (ccRCC) risk in 608 cases and 629 controls frequency-matched on age and gender. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusting for age, gender, BMI, smoking status, history of hypertension, total energy intake and physical activity. Our results suggest an association between low mtDNAcn and ccRCC risk (OR = 1.28, 95% CI: 0.97-1.68, P=0.09). Lower mtDNAcn was associated with increased ccRCC risk in younger individuals (Age<60, OR=1.68, 95% CI: 1.13-2.49, P=0.01), women (OR=1.66, 95% CI: 1.03-2.73, P=0.04), individuals without history of hypertension (OR=1.62, 95% CI: 1.09-2.41, P=0.02) and individuals with low physical activity levels (OR=1.55 95% CI: 1.02-2.37, P=0.05). We observed significant and marginally significant interactions between both age and history of hypertension and mtDNAcn in elevating ccRCC risk (P for interaction=0.04 and 0.07, respectively). Additionally, low mtDNAcn was associated with ccRCC risk in younger individuals with low levels of physical activity [ORs and 95% CI for medium and low physical activity levels respectively, 2.31 (1.18-4.52) and 2.09 (1.17-3.75), p-interaction 0.04]. To our knowledge, this is the first report to investigate the role of mtDNAcn in the clear cell renal cell carcinoma subtype and the first to suggest that this association may be modified by risk factors including age, gender, history of hypertension and physical activity. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: firstname.lastname@example.com 12/2014; 36(2). DOI:10.1093/carcin/bgu248 · 5.27 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Background Renal neuroendocrine tumors (NET), comprising carcinoid tumors and small cell carcinomas, are a rare group of neoplasms. The rarity of these tumors poses a diagnostic and therapeutic challenge. Our purpose was to characterize the cases treated at a tertiary cancer center and to evaluate patients' outcomes with the available treatment modalities. Methods This is a retrospective study of patients with renal NET seen at The University of Texas MD Anderson Cancer Center between January 1, 2001, and January 1, 2011. Patient and tumor data were analyzed by descriptive statistical methods. Results Three cases of carcinoid tumors and six cases of small cell carcinoma were identified. The median age at diagnosis was 53 years for patients with carcinoid and 65 years for patients with small cell carcinoma. The most common presenting symptoms were back pain, flank pain, and hematuria. The morphological appearance of the tumor cells and their immunohistochemical reactivity for neuroendocrine markers and cytokeratin helped establish the diagnosis. Nephrectomy was the mainstay of treatment for carcinoid tumors, yielding good long-term results, even in the presence of metastases. Surgery and chemotherapy were utilized for small cell carcinoma of the kidney. The median overall survival for patients with small cell carcinoma of the kidney was 17.3 months. Conclusion Renal carcinoid tumors are indolent and are associated with prolonged survival, while small cell carcinomas of the kidney are aggressive tumors with relatively short overall survival. Although palliative in nature, cytotoxic chemotherapy is the mainstay of therapy and is best given before surgery.Clinical Genitourinary Cancer 12/2014; DOI:10.1016/j.clgc.2014.06.008 · 1.69 Impact Factor
Article: Multi-Institutional Validation of the Predictive Value of KI-67 in Patients with High-Grade Urothelial Carcinoma of the Upper Urinary Tract.[Show abstract] [Hide abstract]
ABSTRACT: To validate the independent predictive value of Ki-67 in patients with high-grade upper tract urothelial carcinoma (UTUC). 475 patients from the international UTUC collaboration who underwent extirpative surgery for high-grade UTUC were included in this study. Immunohistochemical staining for Ki-67 was performed on tissue microarray (TMA) formed from this patient cohort. Ki-67 expression was assessed in a semi-quantitative fashion and considered overexpressed at a cut-off of 20%. Multivariate analyses (MVA) were performed to assess independent predictors of oncological outcomes and Harrell's C indices (HCI) were calculated for predictive models. Median age of the cohort was 69.7 years and 55.2% of patients were male. Ki-67 was overexpressed in 25.9% of patients. Ki-67 overexpression was significantly associated with ureteral tumor location, higher pT-stage, lymphovascular invasion, sessile tumor architecture, tumor necrosis, concomitant carcinoma in situ (CIS), and regional lymph node metastases. In Kaplan-Meier analyses, overexpressed Ki-67 was associated with worse recurrence-free (RFS) (HR 12.6, p<0.001) and cancer-specific survival (CSS) (HR 15.8, p<0.001). In MVA, Ki-67 was an independent predictor of RFS (HR 1.6, 95% CI 1.07-2.30, p=0.021) and CSS (HR 1.9, 95% CI 1.29-2.90, p=0.001). Ki-67 improved HCI from 0.66 to 0.70 (p<0.0001) for both RFS and CSS in our preoperative model, and from 0.81 to 0.82 (p=0.0018) for RFS and 0.81 to 0.83 (p=0.005) for CSS in our post-operative model. Ki-67 was validated as an independent prognostic predictor of RFS and CSS in patients treated with extirpative surgery for high-grade UTUC in a large, multi-institutional cohort. Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.The Journal of Urology 11/2014; 193(5). DOI:10.1016/j.juro.2014.11.007 · 3.75 Impact Factor
Article: Evaluation of the Prognostic Significance of Altered Mammalian Target of Rapamycin Pathway Biomarkers in Upper Tract Urothelial Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the prognostic value of altered mammalian target of rapamycin (mTOR) pathway biomarkers in upper tract urothelial carcinoma (UTUC). We performed a multi-institutional review of clinical and pathologic information on patients receiving extirpative surgery for UTUC from 1990 to 2008. Immunohistochemistry for phosphorylated-S6, mTOR, phosphorylated-mTOR, PI3K, phosphorylated-4EBP1, phosphorylated-AKT, PTEN, HIF-1a, raptor, and cyclin D was performed on tissue microarrays from radical nephroureterectomy (RNU) specimens. Prognostic markers were identified and the significance of altered markers was assessed with the Kaplan-Meier analysis and the Cox regression analysis. Six hundred twenty patients were included. Over a median follow-up of 27.3 months, 24.6% of patients recurred and 21.8% died of UTUC. On multivariate analysis, PI3K (odds ratio, 1.28; P = .001) and cyclin D (odds ratio, 3.45; P = .05) were significant predictors of clinical outcomes. Cumulative marker score was defined as low risk (no altered markers or 1 altered marker) or high risk (cyclin D and PI3K altered). Patients with high-risk marker score had a significantly higher proportion of high-grade disease (91% vs 71%; P <.001), non-organ-confined disease (61% vs 33%; P <.001), and lymphovascular invasion (35% vs 20%; P = .001). The Kaplan-Meier analysis demonstrated a significant difference in cancer-specific mortality (CSM) based on the risk groups. On Cox regression multivariate analysis for CSM incorporating non-organ-confined disease, grade, lymphovascular invasion, tumor architecture, and marker score, high-risk biomarker score was an independent predictor of CSM (hazard ratio, 1.5; 95% confidence interval, 1.04-2.3; P = .03). Alterations in mTOR pathway correlate with established adverse pathologic features and independently predict inferior oncologic outcomes. Incorporation of mTOR-based marker profiles may allow for enhanced patient counseling, risk stratification, and individualized treatment regimens. Copyright © 2014 Elsevier Inc. All rights reserved.Urology 11/2014; 84(5):1134-40. DOI:10.1016/j.urology.2014.07.050 · 2.13 Impact Factor
Article: Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the Kidney: A Retrospective Detailed Study of Radiologic, Pathologic and Clinical Outcomes[Show abstract] [Hide abstract]
ABSTRACT: Objective To characterize the clinical, radiologic and histologic features of Mucinous Tubular and Spindle Cell Carcinoma (MTSCC), as well as oncologic outcomes.Patients and methodsThis is a single institution retrospective analysis of all MTSCC patients from 2002-2011.Patients were excluded if MTSCC could not be confirmed on pathology re-review (n=4).Clinical characteristics, pathology, imaging, and outcomes were reviewed for the 19 included patients.ResultsMedian age at diagnosis was 59 years (range 17-71) with a female predominance (78.9%).On contrast enhanced CT scan, MTSCC enhanced less than the cortex during the corticomedullary phase. Mean tumor attenuation was 36 HU (range 24-48), 67 HU (range 41-133), 89 HU (range 49-152), and 76 HU (range 52-106) in the precontrast, corticomedullary, nephrographic and excretory phases, respectively.Sixteen patients were treated with partial (N=5) or radical nephrectomy (N=11) for pT1(62.5%), pT2(31.3%), and pT3a disease(6.3%). One patient had active surveillance. Of 3 patients(13.0%) managed with energy ablation, there was one recurrence that was treated with salvage surgery.One patient(5.3%) had metastatic disease at diagnosis and died of disease 64.7 months later. A patient with a pT2bN0M0 MTSCC with sarcomatoid dedifferentiation developed bone metastases 9.5 months after diagnosis and was alive at 19.0 months. The remainder were free of recurrence or progression.ConclusionMTSCC is a rare RCC variant. In this largest series to date, MTSCC presented at a broad range of ages and displayed a female predilection.Imaging and pathologic features of MTSCC display some overlap with papillary RCC.MTSCC is associated with excellent outcomes overall, but is not universally indolent.BJU International 11/2014; DOI:10.1111/bju.12992 · 3.13 Impact Factor
- European Urology 10/2014; 67(3). DOI:10.1016/j.eururo.2014.10.030 · 12.48 Impact Factor
Article: Preoperative Predictors of Pathologic Lymph Node Metastasis in Patients with Renal Cell Carcinoma Undergoing RPLND.[Show abstract] [Hide abstract]
ABSTRACT: Patients with locally advanced renal cell carcinoma (RCC) represent a subset of patients who may benefit from retroperitoneal lymph node dissection (RPLND). We aimed to identify preoperative clinical predictors of positive lymph nodes in patients with RCC without distant metastasis who underwent RPLND.The Journal of Urology 10/2014; 193(4). DOI:10.1016/j.juro.2014.10.096 · 3.75 Impact Factor
Article: Intraoperative Sonography During Open Partial Nephrectomy for Renal Cell Cancer: Does It Alter Surgical Management?[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVE. The purpose of this study is to evaluate whether intraoperative ultrasound (IOUS) during open partial nephrectomy alters the surgical management for renal cell cancer (RCC). MATERIALS AND METHODS. One hundred ninety-eight consecutive patients undergoing IOUS during open partial nephrectomy for RCC were selected for retrospective review of clinical and imaging data. Patient age and sex, the local extent of the primary lesion, and the presence of additional lesions were recorded. Ultrasound findings were compared with preoperative CT or MRI to determine whether the IOUS findings changed surgical management. Summary statistics were performed to assess what percentage of patients with additional IOUS findings had a change in their surgical management. The Kaplan-Meier method was used to estimate 5-year overall survival (OS) and event-free survival (EFS) rates for all patients. Patients were followed for 9-12 years to assess survival and measure recurrence rates. RESULTS. Twenty-one of 198 patients (10.6%; 95% CI, 6.7-15.8%) had additional findings on IOUS not seen on preoperative imaging. As a result, surgery was modified in 15 of these 21 patients (71.4%; 95% CI, 47.8-88.7%). The 5-year OS rate was 81%, and the EFS rate was 76% for the whole group; most deaths were due to unrelated causes. There was no statistically significant difference in OS (p = 0.867) and EFS (p = 0.069) rates among patients who had a change of management because of additional lesions seen by IOUS. CONCLUSION. IOUS performed during open partial nephrectomy for resection of RCC shows additional findings compared with preoperative cross-sectional imaging that may alter surgical management.American Journal of Roentgenology 10/2014; 203(4):822-827. DOI:10.2214/AJR.13.12254 · 2.74 Impact Factor
Top Journals
- The Journal of Urology (46)
- European Urology (30)
- The Journal of urology (22)
- BJU International (21)
- Cancer (13)
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
- • Department of Urology
- • Genitourinary Medical Oncology
- • Department of Epidemiology
University of HoustonHouston, Texas, United States
University of Texas Southwestern Medical Center
Dallas, Texas, United States
- Department of Urology
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia
- Peter MacCallum Cancer Center
Keio UniversityEdo, Tōkyō, Japan
Memorial Sloan-Kettering Cancer CenterNew York, New York, United States
University of California, Davis
Davis, CA, United States
- Department of Urology


text:
Great food, nice people, good price. Place looks like a dive but it's amazing. Loved the food and it was plentiful given the price. Highly recommend!!
3 Days in New Orleans
Best Food in New Orleans
This is the cats pajamas the bees knees. The party's are delish and so is the jerk chicken. Overall very impressed.
This place is not at all inviting from the outside, but don't let this dissuade you. The food is great! Inside is a huge mural of a tropical beach and friendly service. They have lunch buffet available most days or order off the menu- also available for take out. The rice and peas are great, the fried plantains are great...
This is the second time I've visited this place. The first time I stumbled across this place it appeared to be undergoing renovations. A year later and the same holes in the ceiling and exposed beams remained. So the atmosphere well, just call it non existent. When I entered the establishment this time, we were not greeted again so we...
Stopped by Boswell's on my first trip to New Orleans and it was AMAZING! Best Jamaican food I've found.
The lunch buffet was pleasing in both quantity and quality. There was enough variety to suit most palates, but there wasn't an overwhelming amount of food to sample. It's definitely worth a visit when the Reggae music and Jerk spice craving comes.
This is real down the equator style island cooking. Callaloo alone is worth a trip. But the tail rules supreme here. Slow simmered, gelatinous gooey, goodness on a bone.
I am Jamaican so it is mandatory that I have access to a Jamaican restaurant when necessary. I did a search for a local restaurant and only 3 options popped up. The only one that seemed to be authentic was Boswell's Jamaican Grill.
I headed over there to get my fix. The restaurant itself was very plain and underwhelming. It...
This place makes sure you experience the tates of the caribbean. There are several things on the menu that are hard to come by in the city of New Orleans " For example Ting. My suggestion is to make you way for the all you can eat luch buffet special, where you can try jerk, curry other spices from the...
Great food! I enjoyed the dinner here. The menu offered all the national dishes: Escovitch, ackee & salt fish, curried goat and chicken, roti, fried plantains, callaloo, jerk chicken, rice and peas, and Ting beverages. Festival is available on special occasions. Boswell's even has their own homemade jerk sauce that adds a little kick to the jerk chicken! I could've...
Register now for free — and start getting automatic notification of new reviews, responding to traveler feedback, adding new photos to your listing and much more.


text:
this wiki
All pages can be edited and you are welcome to join us and contribute to this wiki.
1,030 articles since 8 June 2012.
Ni no Kuni
Learn more about the PS3 release.
Meet the cast of Ni no Kuni.
Learn more about playing Ni no Kuni.
Explore the world of Ni no Kuni.
|Ni no Kuni is a role-playing game developed by Japanese developer Level-5 and co-produced with Studio Ghibli. The game was originally released in Japan for the Nintendo DS on December 2010. In the United States, it was released for the PlayStation 3 on January 22, 2013. Read more about Ni no Kuni...
|Featured Videos
|Helping Out
To write a new article, just enter the article title in the box below, but be sure to check if there's already an article before you make it!
|Gaming Wikis
We apologize, database maintenance in progress. Editing is locked while we update our system.
Breath of Fire • Chrono • Dark Cloud • Dragon Quest • EarthBound • Encyclopedia Gamia: RPG Portal • Final Fantasy • Fire Emblem • Golden Sun • Grandia • Kingdom Hearts • Lost Odyssey • Mana • Megami Tensei • Ni No Kuni • Phantasy Star • Pokémon • Shadow Hearts • Skies of Arcadia • Star Ocean • Suikoden • Valkyria Chronicles • Wild Arms • Xenoblade • Xenosaga
|Community Blogs
|Ni No Kuni Wiki is now social!
|Tweets by @NiNoKuniWiki
|Like us on Facebook!


text:
With raw and emotional witness testimonies, CCTV footage and shocking reconstructions, this gripp...(01:05)
As the dust settles on this dark chapter in Norway's history, explore the uncomfortable truths ...
Get up close with amazing creatures.
The official UK page for Nat Geo WILD
The official stream of Nat Geo TV.
Find out what's on with our monthly programme updates.
Follow them on unique adventures around the world. Let them inspire you to create new experiences of your own.
Cookies are very small text files that are stored on your computer when you visit some websites.
We use cookies to make our website easier for you to use. You can remove any cookies already stored on your computer, but these may prevent you from using parts of our website.
Strictly necessary and performance


text:
Loading stream...
Now Playing
Connect with Us
Podcasts & RSS Feeds
|All Content
|View all podcasts & RSS feeds
Most Active Stories
- Equality in Alabama? Same-Sex Marriage Reactions
- Alabama Universities Receive Accreditation Warning
- Alabama's Reaction to U.S. Supreme Court's ruling on Same Sex Marriage, Child Care sickness suits
- Same-Sex Marriage couples having trouble getting marriage licenses, Veteran honored in Sylacauga
- Tama the Stationmaster Cat
The Two-Way
7:14 am
Fri February 1, 2013
Alabama Hostage Standoff Continues
By Mark Memmott
The standoff continues this morning in Midland City, Ala., where a 5-year-old boy has been held captive in an underground bunker since Tuesday, when a gunman abducted him from a school bus after killing the driver.
Authorities are talking to the suspect, 65-year-old Jimmy Lee Dykes, through a pipe that leads to the bunker. Local Sheriff Wally Olson, according to AL.com, says "there is no reason to believe the child has been harmed."
Idaho's KHQ-TV spoke with a sister of the fatally wounded bus driver, who authorities say had tried to stop the gunman from taking any of the children. Vicki Upchurch says her brother, Charles Poland, "would have done anything to protect those kids."
Copyright 2013 NPR. To see more, visit http://www.npr.org/.


text:
Tags » Rhondda Cynon Taf
Regular event - Cardiff City Premier Kicks, AberdareFootball
Regular event - Cardiff City Premier Kicks, PorthFootball
A Nice Little Earner
In which The Author comes up with a new revenue stream for his local authority
In 400 Blows I told you what happened last time I exchanged a casual comment with a stranger in Aberdare Library. 914 more words
There's Nothing to See
In which The Author issues an apology
You're probably wondering what's happened to the daily picture which I promised you at the end of last week, as my contribution to the Photo101 project. 437 more words
New Local News Wesbsite for the Rhondda Fach!
This website has been set up due to the lack of news coverage for the Rhondda Fach area.
It is a news, views and what's on platform for people who live in the Rhondda Fach. 51 more words
Regular event - Bipolar Support Group, Aberdare
Click here to check any last minute changes, or to find your nearest support group.
Twitter: @BipolarUK


text:
The SE Louisiana Freethinkers & Nonbelievers Group (NOSHA)
NOSHA Meet & Greet: What is Humanism?
NOSHA is branching out to our friends in Metairie and will hold a meet-and-greet session to enjoy the marvelous Jefferson Parish Library!NOSHA board member Chris Baudot... Learn more
- Jefferson Parish Library
- 4747 W. Napoleon Ave., Metairie, LA (map)
Hosted by: Charlotte (Organizer)
NOLA Science Cafe - "14 Billion Years Since the Bang"
Astrophysicists have estimated the universe's age to 13.82 billion years, but how? How do we know? Jason Talley will show us how astronomers measure the size and age of... Learn more
- Neutral Ground Coffeehouse
- 5110 Daneel St., New Orleans, LA (map)
Hosted by: Charlotte (Organizer)
Overcoming the Fear of Death
Death is inevitable. But what is it? There are four belief systems about death: • No belief in the afterlife • Afraid of heaven or hell • Looking forward to heaven • ... Learn more
- Jefferson Parish Library
- 4747 W. Napoleon Ave., Metairie, LA (map)
Hosted by: Charlotte (Organizer)
Screening - Godless in America: The Extraordinary Life of Madalyn Murray O'Hair
The secular community has heard lots of discussion about the "new atheists" in recent years, but there was one "original" atheist who set the world on fire with her... Learn more
- Audubon Zoo
- 6500 Magazine St, New Orleans, LA (map)
Hosted by: Charlotte (Organizer)
Screening of Planet Earth
NOSHA will present an episode of Planet Earth that describes a more naturalistic and science-based view of the human experience. Planet Earth was a 2006 British... Learn more
- Jefferson Parish Library
- 4747 W. Napoleon Ave., Metairie, LA (map)
Hosted by: Charlotte (Organizer)
Recent Meetups
June 28 · 11:00 AMHeretics Brunch - JuneWe haven't done brunch in a while, so we must usher in the summer with some sangria and Southwestern cuisine. It's too hot outside to let another month pass us by. As... Learn more
June 26 · 5:30 PMDecision Day Rally for Marriage EqualityCome with your partners, wives and husbands! Bring the entire family! Invite along your friends, neighbors, allies and co-workers! Don't forget your signs, banners, and... Learn more
June 20 · 5:00 PMCelebrate the Summer Solstice with NOSHA!Every June, NOSHA takes a break from our usual monthly activities to enjoy good food with good friends! Many thanks to Harry Greenberger and Marshall Harris for hosting... Learn more
June 8 · 9:00 AMHumanists at the Capitol and "Ask An Atheist" DayA first-time event for the non-religious community in Louisiana!NOSHA along with various humanist and atheist organizations from around the state will have information... Learn more
June 7 · 6:00 PMLoosen The Bible Belt - A Tour for HumanityThere is a suggested donation of $20.00 that gets you admission to the crawfish boil that starts at 6pm and ONE drink (a cash bar is available) . The show starts at 7pm.... Learn more
- See all past Meetups


text:
We are after a new logo for our website. The old one has been mocked up as a temporary one, and now it's time to change.
We would like a logo that is modern, sleek and stylish like our products. Our main demographic are men/women between the age of 16 and 45 who want to change the style and colour of their mobile phones, however they don't want the bulk of a large mobile phone case.
Our logo must be clean, sleek and stylish with a classy touch. We don't mind if the logo is just text, or image or both. The logo will be used on many mediums so it must be simple enough to be used on products, packaging, promotions and web publishing.
We don't care about the colour, our old colour scheme was light red and very dark grey, however we are happy for that to change as we aren't even sure we like it anymore. Check out the website [url removed, login to view] for examples of our products and also our previous logo. The website theme will be changing soon also so don't bother matching it with that.
We also want a logo that doesn't age, like our current one will. Our main competitors are SlickWraps, ColorSwitch, Skinit and Zazzle.
If possible we would like a logo, then a simplified version (maybe initials or something) that can be used when needed.
We have attached photos of logos that look nice in the same field.
The best logo in the competition will be awarded prize.
Here is a breakdown of our brand name:
TRIM - Tight, Slim, Sexy, Sharp, Precision, Quality, Premium.
SKINS - Protection, Membrane, Shell, Barrier, Sticker, Shield, Safe.
Seal your entry to ensure your idea is unique. Only you and the contest holder will be able to view your sealed entry.
Highlight your entry to make it visually stand out from the rest!
Please ensure the following:
Supported file types:


text:
Guides I've Contributed To
My Favorite Guides
Completed Guides
Answer to: I mac will not boot upIt's possible that 1 of 2 things has happened. Either your hard drive has failed or the logic board has failed. Before you try any repair though, I would recommend that you let it sit and cool off before turning it on again.
MacBook Pro 15" Core Duo Model A1150 Upper Case Replacement
If you still have the DVI to VGA adapter that came with the computer plug it in to the plug and screw it tight, that way you will not put one of the screws into the holes.


text:
Week 10 Bears Grades: Offensive line
Moon's Week 10 Grades
There is no data to display.
Bears quarterbacks were sacked once each, but the Lions were credited with 11 quarterback hits and five tackles for loss. One of those came on the thwarted run play for what was intended to be the game-tying two-point conversion.
The inability of the run game (1.9-yard average per carry) left the offense out of balance with too much pressure on a quarterback (Jay Cutler) dealing with health issues.
"(The Lions) are a good front," said center Roberto Garza. "We just didn't do a good job today."
Failure to block Ndamukong Suh in a manner to force him to take his hands down on the quick slant at the end of the first half was devastating and allowed Suh to deflect the throw appeared to fall on left guard Matt Slauson, one of the Bears' best this season. Slauson also was flagged for holding on a first-down run from the Detroit 9, taking away a major opportunity when the Bears were in desperate need of a touchdown, not a field goal.
[MORE: Bears self-destruction hurts more because it came vs. Lions]
The protection on the Bears' first TD pass, to Brandon Marshall, was outstanding and gave Cutler time to wait for Marshall to get position against single coverage. But overall control of the line of scrimmage did not belong to the Bears.
"We didn't execute today like we needed to," said coach Marc Trestman. "We couldn't counteract with enough of a balance in our running game to minimize the pass rush today."
Moon's Grade: D


text:
|Andain, Inc.
400 South Beverly Drive
Suite 312
Beverly Hills, CA 90212
United States - Map
Phone: 310-286-1777
Fax: 310-286-2777
Website: http://www.andaininc.com
Andain, Inc. is engaged in development and commercialization of technologies in the biotechnology and medical fields in the United States. The companys products include miniature disposable insulin pumps, stem cell therapy for muscular injuries, and organ-targeted nano-particles for drug delivery via inhalation. It also develops ultrasonic catheters for brain cancer therapy and peptide boosters for anti-wrinkle cosmeceuticals. Andain, Inc. was founded in 2004 and is based in Beverly Hills, California.