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Letting Sleeping Dogs Lie
The California stem cell research agency is at risk of losing its identity. Back in the fall of 2004, when voters were convinced to pass Proposition 71, creating the California Institute for Regenerative Medicine (CIRM), we were told that the new agency and the work it would fund would lead to cures and an economic boom. Since then, the hyped potential of embryonic stem cell research has cooled a bit, and new techniques to derive fully potent stem cells without embryo destruction have been discovered. And it now appears clear that the next US president will lift the federal funding restrictions on using human embryos for stem cell research. Together, these developments call into question the relevance of a multi-billion dollar state-level set-aside, particular as California reels from debt.
Of all the claims of the Proposition 71 campaign, its lavish economic argument was undermined most rapidly. For example, in the campaign's original analysis [PDF], the state would receive up to $1.1 billion in revenue from successful developments, and on top of that, California's share of royalties and licensing would be streaming in before the agency's bond payments start in 2010. Although that was a fantasy in 2004, such an optimistic forecast appears even more unrealistic now, considering that the first clinical trials for a potential embryonic stem cell therapy - which were in the pipeline long before CIRM - will not commence until next year, at the soonest. To top it off, Robert Klein, Proposition 71's author and campaign chair, was caught in 2005 misleading the voters [PDF, page 9] over whether such revenues were even possible. Since then, other critics have acknowledged that the research advocates financial analysis was unrealistic at best (1, 2, 3, 4)
Now, the leadership of the CIRM has commissioned a new economic report. While its results will certainly be more tempered in the absence of an electoral campaign, it will be authored by the same consulting group used in 2004 by the campaign. My suspicion is that it is being prepared to be a defense against any potential legislative threats to CIRMs state funds. Unfortunately for CIRM, any realistic economic analysis may not be an effective shield in Sacramento during a period of drastic budget cuts. What's more, by reviving past controversy, revisiting the economic argument may backfire. Sometimes it is better to let sleeping dogs lie.
Previously on Biopolitical Times:
Henry Louis Gates Jr. Interviews James Watson
Back in October of last year, James Watson started a heated debate over race and genetics by making a series of statements suggesting that Blacks are an inherently inferior racial group. To recap, Watson noted that he is inherently gloomy about the prospect of Africa since all our social policies are based on the fact that their intelligence is the same as ours whereas all the testing says not really. Moreover, he is quoted as saying that there is no firm reason to anticipate that the intellectual capacities of peoples geographically separated in their evolution should prove to have evolved identically. Our wanting to reserve equal powers of reason as some universal heritage of humanity will not be enough to make it so.
Race scholar Henry Louis Gates Jr., who has filmed two documentaries on race, genetics, and ancestry while also founding a DNA ancestry company, was troubled by Watsons seemingly pernicious use of race and genetics particularly since Gates has said that he has been among those who have long held Watson in high regard. This led Gates to interview Watson to, in a sense, determine whether hes a bigot. Gates concludes:
I don't think James Watson is a racist. But I do think that he is a racialistthat is, he believes that certain observable traits or forms of behavior among groups of human beings might, indeed, have a biological basis in the code that scientists, eventually, may be able to ascertain, that the "gene" is some mythically neutral space and what it purportedly "measures" or "determines" is independent of environmental factors, variables and influences.
The difference, the distinction, between being a racist and a racialist is crucial. James Watson is not the garden-variety racist as he has been caricatured by the press and bloggers, the sort epitomized by David Duke and his ilk, and he seemed genuinely chagrined, embarrassed and remorseful that Duke and other racists had claimed him as their champion, as one of their own, because of his remarks as quoted in the London Sunday Times. And, as we might expect, he apologized profusely for those remarks, contending that he had been misquoted, at worst, and his remarks taken out of context, at best.
You can read the full transcript of Gates interview with Watson here. Are you persuaded by Gates distinction between a racist and a racialist? Post your thoughts in the comments.
Partisan fratricide over stem cells in Missouri?
Just when you thought that the strange saga of stem cell research policy in Missouri was over, think again. Two years ago, the state underwent an expensive, divisive battle over the issue - but for little significant policy change. Now, a group of state Republicans appears ready to repeat the strife, again with little policy implication, but this time within the ranks of their party.
In 2006, a wealthy Missouri couple successfully bankrolled a ballot initiative which constitutionally protected all forms of human embryonic stem cell research in Missouri. It was a bit superfluous, however, because at the time, the closest thing to a threat to the work was a bill introduced annually by a conservative senator to ban cloning-based stem cell research. This bill had never even made it to the Senate floor, and both the Republican governor and his likely future Democratic opponents had promised to veto any such ban. To top it off, cloning-based stem cell research was not performed in Missouri, nor were there any plans to do so. It was thus something of a mystery as to why Jim and Virginia Stowers were so eager to spend over $30 million on Amendment 2, which passed by a small margin.
But in January of this year, Governor Blunt announced that he would not run for reelection this fall. While the two major Republican contenders to take his place oppose embryonic stem cell research, the constitutional protection remains in place. However, the state's largest newspaper just reported that
Nineteen of the region's most prominent and generous Republicans - who over the years have donated millions of dollars to their party and its candidates - have launched a new effort aimed at protecting embryonic stem-cell research....
[Republicans To Protect Medical Advances founder William] Danforth indicated that some of the founders may link financial support to a candidate's position on the research.
Nineteen of the region's most prominent and generous Republicans - who over the years have donated millions of dollars to their party and its candidates - have launched a new effort aimed at protecting embryonic stem-cell research....
[Republicans To Protect Medical Advances founder William] Danforth indicated that some of the founders may link financial support to a candidate's position on the research.
What makes the establishment of Republicans To Protect Medical Advances even stranger is that (contrary to the claims of the St. Louis Post-Dispatch) the new Missouri Republican party platform [PDF] does not actually oppose embryonic stem cell research using IVF embryos. It only is against "all human cloning" and "fetal tissue research."
Isn't this potential gubernatorial threat to embryonic stem cell research exactly what the constitutional amendment was designed to block? Why would party bigwigs lunge for the financial jugular of their own party - and possibly cede the governorship to their opponents - over a debate that will have little effect on actual policy? Although there may be state political dynamics of which I am unaware, Republicans To Protect Medical Advances are more likely to fracture their own party than materially protect "medical advances."
Willy Wonka and the cloning factory
In yet another publicity bid, BioArts International has announced its Golden Clone Giveaway contest. On June 16, the California start-up will award "a free clone of YOUR dog" to the person who submits the best 500-word essay on why their dog is "clone-worthy." BioArts is being run by cloning impresario Lou Hawthorne; disgraced cloning scientist Hwang Woo Suk is also involved.
Why does the Golden Clone contest call to mind the five Golden Tickets hidden by candy entrepreneur Willy Wonka among his billions of chocolate bars? You remember the story: Each lucky child who finds a ticket gets a free tour of Wonka's top-secret factory, along with a lifetime supply of special chocolate.
In the 1971 film based on Roald Dahl's children's novel, Gene Wilder plays Wonka as a creepy guy who looks on placidly as one child after another barely escapes a grisly fate, the just desserts, so to speak, of sneaking a taste of the wares. One girl is transformed into a giant blueberry; another child is shrunk to a few inches high; a third is rejected as a "bad egg" and sent down a garbage chute into the Egg Sorting Room. The factory workers - the Oompa-Loompas, who in the 2005 (post-Dolly?) remake of the movie were all played by the same actor, Roy Deep - break into song after each mishap.
Do similar outcomes await those partaking in the Golden Giveaway? Is Lou Hawthorne biotech's Willy Wonka? Stay tuned.


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Extended Stay America Austin - Downtown - Town Lake, Austin
- Free continental breakfast, free WiFi, and free parking
Main amenities
- 130 guestrooms
- 24-hour front desk
- Coffee/tea in the lobby
- Air conditioning
- Front desk safe
- Self-serve laundry
- Luggage storage
What's around
- In Downtown Austin
- Governor's Mansion (1.1 mi / 1.8 km)
- Texas State Capitol (1.6 mi / 2.5 km)
- Zilker Park (1.6 mi / 2.5 km)
Close to all of the action of Downtown and the shops along South Congress. Perfect for a…
ideally located between town & SoCo. walkable to both. Large comfortable room equipped…
Enter dates to check prices
Hotel Info: 020 3027 9803from £94
- Deluxe Studio One King Smoking
- Deluxe Studio One King Non Smoking
- Studio One Queen Non Smoking
- Studio One King Non Smoking
- Studio One Queen Smoking
- Studio Two Queens Non Smoking
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At a glance
Key facts
Hotel size
- This hotel has 130 rooms
- This hotel is arranged over 3 floors
- Check-in time starts at 3 PM
- Check-out time is 11 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Children (17 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Pets allowed (dogs and cats only) *
- Restrictions apply *
- 2 per room
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
Nearby Two Star Austin hotels
In the hotel
- Free continental breakfast daily
- Coffee/tea in the lobby
- Use of nearby fitness center (discount)
- Bicycle rentals nearby
- Golfing nearby
- Hiking/biking trails nearby
- Kayaking nearby
- Mountain biking nearby
- Scooter/moped rentals nearby
- 24-hour front desk
- Laundry facilities
- Luggage storage
- Year Built 1998
- Elevator/lift
- Safe-deposit box at front desk
In the room
- Climate control
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
- Blackout drapes/curtains
- Private bathroom
- Shower/tub combination
- Free toiletries
- Hair dryer
- 32-inch flat-screen TV
- Premium TV channels
- Free WiFi
- Free local calls
- Full-sized refrigerator/freezer
- Microwave
- Kitchen
- Stovetop
- Cookware, dishware, and utensils
- Weekly housekeeping provided
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Extended Stay America Austin - Downtown - Town Lake, Austin's small print
A valid credit card is required at check-in for incidentals/damages otherwise a US$100 cash deposit per stay, per room will be collected. The deposit is refunded at check-out after satisfactory inspection. If refund is over US$100 a check will be mailed within 14 days of departure.
Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation.
Mandatory fees
Cash deposit: USD 100 per stay
Optional extras
Weekly housekeeping is provided; fees apply for additional cleaning
Pets are allowed for an extra charge of USD 25 per accommodation, per day (maximum USD 150 per stay)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.

subset: commoncrawl


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- Jon Mahoney, ESPNHS.com
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The walls of Gateway head football coach and athletic director Terry Smith's office are adorned with framed pictures of all the players who have gone on to play Division I college football since he took the helm in 2002.
Under Smith, more than 20 players have earned that distinction, including cornerback Justin King, who starred at Penn State and was drafted by the St. Louis Rams in the fourth round of the 2008 NFL Draft. The storied legacy isn't lost on younger players who arrive at Gateway with dreams of joining King and co. on the wall. And seniors Dorian Bell and Corey Brown were no different when they entered the program in the fall of 2005.
Those dreams will soon become a reality for Bell and Brown, who make up arguably the nation's top prep duo in the Class of 2009. Both have committed to NCAA powerhouse Ohio State.
"It's a big honor to be up on that wall," Bell says. "I just wanted to be one of those great guys who went to Gateway."
Bell and Brown have made such an impression on Smith that he calls them two of the best players to ever don Gateway's black and gold.
The 6-foot-1, 225-pound Bell is rated the nation's No. 4 linebacker and No. 11 overall recruit in the ESPNU 150 after registering 228 tackles and 13 sacks the past two seasons. The 6-foot-1, 186-pound Brown, a cornerback/wide receiver, racked up nearly 1,000 receiving yards and 10 touchdowns to go with six interceptions the last two years.
"It doesn't matter what's coming at Dorian, he'll make the play," Smith says. "Dorian has that truck power, but he also has that athleticism that's a wow factor."
"Corey has some of the best ball skills you'll ever see," Smith continues. "Any time the ball is in the area, he knows how to go get it. He's going to stick his nose in there and try to lay the wood on you."
The precocious pair trace their rise to gridiron prominence back to elementary school, when they became friends thanks to a shared passion for competition. Bell and Brown often battled for athletic supremacy, whether it was in a
head-to-head sprint or a one-on-one hoops clash.
But it was on the football field where their competitiveness was fiercest. Bragging rights were always on the line in the sport they loved most.
"We've always been competitive because we've always wanted to be
better than the other," Brown says.
Even today, Bell and Brown continue to duke it out during Gateway
practices and workouts. Smith recalls a team workout last spring where a number of college coaches watched the two go all out, sometimes even breaking into shouting matches.
"They bring out the best in each other," Smith says. "When one is a little tired, the other is going to lay into him so he isn't tired. I love it because I don't have to motivate those two. They understand the big picture."
Smith likes to tell his players that in football, like life, you've got to earn what you get. And having Gateway's underclassmen watch two elite recruits go at it every day in practice shows that the best always stay hungry.
Bell learned that the hard way. As an eighth-grader, he was called up to play for the freshman team but only participated in a couple games after breaking his ankle. He figured being called up to freshman ball early meant he was
ticketed for JV the next year. However, Smith gave Bell a dose of reality when he kept him on the freshman team because his progression as a player wasn't where the team wanted it. Brown, on the other hand, earned a spot on JV in his freshman season.
The experience woke Bell up in a hurry.
"I wasn't a complete player," says Bell, who will also play running back on offense this fall. "I didn't have my head on right. I was really immature."
"I think playing on the freshman team pissed him off," Smith adds. "We told him he had to prove it."
And Bell did that the following season when he earned a starting spot on varsity at linebacker and tight end. Brown, who impressed on JV his freshman year, was also a two-way varsity starter as a sophomore.
Both delivered solid campaigns that season, but it was last year when they went from good to great. Bell tallied 131 tackles, including 25 for loss, and 11 sacks to earn a spot on both the Pittsburgh Post-Gazette Fabulous 22 and Pittsburgh Tribune-Review Terrific 25 teams.
"He's fast, physical and knows a lot about the game," Brown says. "And he's emotional about it -- he'll knock your head off."
Brown, meanwhile, caught 20 passes for 470 yards and three scores on offense and recorded 34 tackles, 23 pass breakups and four picks on defense last fall. He was named to the All-Conference first team along with Bell.
Brown, who looks up to NFL All-Pro cornerback Champ Bailey, will focus on playing corner for the Buckeyes.
"Corey can do anything," Bell says. "He's an all-around athlete."
Gateway finished the 2007 season 11-2 after falling to eventual state
champion Pittsburgh Central Catholic, 35-34, in overtime in the WPIAL Class AAAA finals. It was one of the greatest games in WPIAL history, but the Gators take no solace in that and still have a sour taste in their mouths thinking about what could have been.
"We experienced getting there, but now we want to experience winning there," says Smith, whose team began the year ranked No. 7 in the ESPN RISE FAB 50. "It drives our workouts every day."
Leading the charge are the team's two best players, Bell and Brown, who are constantly looking to improve the team while also battling each other for the upper hand.
But in the end, they'll both reach the same place -- immortalized in a photo on their coach's wall.
Jon Mahoney covers high school sports for ESPNRISE.com.
Sources: Pistons, G Jackson agree to $80M deal
3hBrian Windhorst
Sources: Cavs look to land Johnson from Nets
9hBrian Windhorst
Tiger encouraged by final round at Greenbrier
2hJason Sobel
Pacers re-sign Stuckey to 3-year deal, agent says
7hBrian Windhorst
Lakers closing in on deal for Hibbert, sources say
1dMarc Stein and Ramona Shelburne
All-Star Game starters are in; how will the rest of the rosters round out?
5hDavid Schoenfield
Sources: LeBron talks quiet as Cavs work deals
1dBrian Windhorst
Talented teammates are Buckeye-bound


text:
text modeA video mode in which a display screen is divided into rows and columns of boxes. Each box can contain one character. Text mode is also called character mode.
All video standards for the PC, including VGA, support a text mode that divides the screen into 25 rows and 80 columns. In addition to text mode, most video adapters support a graphics mode, in which the display screen is divided into an array of pixels.
Whereas character-based programs run in text mode, all graphics-based programs run in graphics mode.
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Welcome everyone!
Spiritual Teacher, Author, Global Activist, Visionary, You Tube Partner, Radio Personality, Reiki Master and Social Critic.
It is no coincidence that you have come to this website. You've probably come to realize that much of this world is upside down and backwards and now you've awakened to a higher truth. Everything is energy and we are all connected. This 3D matrix world is an illusion and your soul yearns for answers. Perhaps you are here because we are always led in the right direction when we have so strongly desired the truth.
I am here to raise the consciousness of humanity during this pivotal time in our planets history. I firmly believe that humanity is awakening and we must take the responsibility to support this process in any way we can. Whether it is in promoting change through activism or developing a greater way of being and living on our planet. I am here to offer some solutions to these challenges for the individual and for our global community as a whole. I hope you will join me in this great work. Together we can raise the consciousness of our planet. One Love
To get you started on this journey check out some these sections of my website.


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Bryan HS Band, Color Guard Marching In National Memorial Day Parade
Posted: 05/19/2014 - 75 students will showcase some of Bryan's best in Washington, D.C.
Posted: 05/19/2014 - 75 students will showcase some of Bryan's best in Washington, D.C.
Updated: 05/19/2014 - 67-year-old Jay Kimbrough suffered several cracked vertebrae after a motorcycle accident Friday.
Posted: 05/19/2014 - Beginning Wednesday, May 21, the SH 6 frontage road intersections of Rock Prairie Road and the westbound lane of University Drive at Texas Avenue will be closed.
Updated: 05/19/2014 - A lengthy new report from the State Fire Marshal's Office describes the frightening last moments of two Bryan firefighters who lost their lives battling a building fire last year.
Posted: 05/19/2014 - The U.S. government is stepping up efforts to help Central American farmers fight a devastating coffee disease - and hold down the price of your morning cup.
Updated: 05/19/2014 - A new place to eat is coming to College Station just in time for football season.Construction of a Saltgrass Steak House recently started in south College Station near the Tower Point H-E-B on Highway 6 at Arrington Road.
Updated: 05/19/2014 - The State Fire Marshal's Office has released its findings in its investigation into the February 2013 fire at the Knights of Columbus Hall in Bryan that left two firefighters dead and two others critically injured.
Updated: 05/20/2014 - KBTX's recently retired news director, Mike George, was found dead Sunday afternoon at his home in College Station.
Posted: 05/19/2014 - No excuses - wear your seat belt. Texas is part of the 13th annual "Click It or Ticket" safety effort to make sure travelers buckle up. The campaign that began Monday and runs through June 1 means law enforcement officers are ready to ticket anyone not using a seat belt.
Updated: 05/19/2014 - Firefighters responded to a house fire in Hearne Sunday evening.
Posted: 05/18/2014 - Shipwreck Grill, The Crawfish Hole and The Bryan Police Officers Association teamed up again this year to host a Crawfish Cook-Off benefiting the 100 Club. So far, event organizers say they raised at least $5,000.
Updated: 05/18/2014 - Three separate small grass fires sparked along Highway 6 this afternoon in south Brazos County.
Posted: 05/18/2014 - An estimated five vehicles were involved in a collision where SH 30 intersects with FM 158 in front of Central Baptist Church around 4:30 p.m.
Updated: 05/18/2014 - Jay Kimbrough, a longtime political adviser to Gov. Rick Perry and the point man for state agency crises through two Republican administrations, remains in serious condition following a Friday motorcycle accident, his family said Sunday.
Updated: 05/19/2014 - The Texas primaries for 2014 are set to conclude Tuesday, May 27, but early voting for the runoffs start Monday and is available through Friday.
Posted: 05/18/2014 - The U.S. government is stepping up efforts to help Central American farmers fight a devastating coffee disease - and hold down the price of your morning cup.
Updated: 05/17/2014 - The Go Fund Me account set up by a police officer in Alabama reached its goal of raising $5,000 late Friday night.
Updated: 05/17/2014 - The Hershey's Track and Field Games wrapped up in Bryan Saturday afternoon.
Updated: 05/17/2014 - The first-ever Sip and Shop in Downtown Bryan Saturday is being called a big success.
Updated: 05/17/2014 - A College Station resident found himself behind bars early Saturday morning after police say shot at cars parked near his home.
Updated: 05/17/2014 - The weather was perfect today to get out and enjoy the outdoors, and that's exactly what many did across the Brazos Valley.
Updated: 05/17/2014 - The 93-year-old woman who was shot and killed by Hearne Police was laid to rest Saturday.
Updated: 05/17/2014 - The teenager pleaded guilty, admitting he was there and knew the store east of Conroe would be robbed.
Updated: 05/18/2014 - A former Deputy Chancellor of the Texas A&M System and close friend of Governor Rick Perry is in critical condition after a motorcycle accident Friday evening.
Updated: 05/28/2014 - Criminal defense attorney says the law is very clear when it comes to using deadly force under Chapter 9 of the Texas Penal code.


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"Apple has limited this feature to locking the orientation in portrait mode only,"
This is not a feature I've seen today. Maybe they'll add it later.
How do I view sideways on iphone 5. Screen locked.
How do I view sideways on iphone 5. Screen locked.
Double click the Home Button.
This shows you the Fast App Switcher.
Swipe from left to right until you see the music player app. You will recognize it by the controls.
On the left of the controls there is an icon with a circular arrow.
If there is a padlock in the middle of the arrow, screen rotation is locked.
Tap it to unlock it.
If screen rotation is locked, you will see an icon at the top right of the screen, to the left of the battery indicator and the Bluetooth icon.
Icon there, screen rotation locked, no icon = no lock
That help?
Find recipes for July 4 with these foodie apps
The Fourth of July means fireworks, fun and food. If you're planning on a barbecue this weekend, we've got the apps to help you find holiday-inspired recipes.


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We stayed here over new year, and overall we were happy with the hotel. The room was large (spacious for a family of 4), clean and modern. The bathroom was good and the beds comfortable. We had a big balcony, but the room was not facing the road so we did not use it much. This place feels like a beach resort and there is a number of pools (including an adult only on the roof). The beach is nice, but the sand is not your usual white coral sand but quite dark volcanic sand. The food is very average (but the breakfast is good) and service is not quick or very alert (we had to wait for over an hour for a couple of soups). The shuttle to the old town has been discontinued, but a taxi is just 12 000 peso so that is not a big deal. The hotel also have a pick-up service at the airport.
- Official Description (provided by the hotel):
- Welcome to Paradise. Rediscover your life in Cartagena de Indias, the city of unforgettable sunsets, endless nights and the astonishing Caribbean Sea while exploring the charms of Las Américas Resort y Centro de Convenciones. The renovated Las Américas Casa de Playa hotel, the new Las Américas Torre del Mar hotel and the 2,000-person capacity ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Orbitz, Booking.com, HotelTravel.com, Odigeo, Hotels.com, Travelocity and Priceline so you can book your Las Americas Torre del Mar reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Las Americas Torre Del Mar Hotel Cartagena


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Texas A&M heads to the San Joaquin Valley for a three-game series against the Fresno State Bulldogs with action starting Friday night at 8:35 pm CT.
Click here for the original story.
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I have 3 male golden retriever pups for sale! AKC registered both parents, healthy and playful and full of life! They are also de-wormed. Upon buying the dog we'll a baggy of Puppy Chow for you! If you're interested, contact us at 415.279.8896 to schedule an appointment!
Jun 25 -
San Francisco Bay Area :
Hayward - Dogs & puppies
Chihuahua Pups 8 weeks beautiful -healthy-ready to go on Puppy Chow. 2 Males and 2 females-Beige and or Black with beautiful markings-will be small-please call DEB 760-373-9090 after 9 AM
$40.00 home raised to loving homes
May 26 -
Central Valley :
California City - Dogs & puppies
Blue chow puppy he is utd on shots and has been hand and family raised he is extremely social and loving. He has basic commands and does well in a enclosed dog park with other dogs and recall. He has been rise with kids cats and other dogs. If intersted please contact me via phone 415-374-3714 ty
May 12 -
San Francisco Bay Area :
San Francisco - Dogs & puppies
This litter is sold, but we are expecting our last litter to be born in August 2015. If you are interested in being contacting with details, please contact me.
There are AKC champions in both lines, which I will provide a record of.
Our puppies will have already had their first vet check, tails and dewclaws docked. They are up to date with shots, flea treatment, come with a bag of Taste ...
May 8 -
Humboldt County :
Eureka - Dogs & puppies
I have a six month old beautiful chow puppy for sale. She she has had all her shots she has been through basic obidence training. She is create trained and potty trained she has been raised with kids cats and dogs. We prefer prior chow experience or knowledge of the breed. Please do not email or text me I will not respond if you are interested in meeting her or more information please call ...
May 5 -
San Francisco Bay Area :
San Francisco - Dogs & puppies
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LightInTheBox Holding Co., Ltd. Announces Management Change Business Wire BEIJING -- January 27, 2014 LightInTheBox Holding Co., Ltd. (NYSE: LITB) ("LightInTheBox" or the "Company"), a global online retail company that delivers products directly to consumers around the world, today announced that its Chief Financial Officer Mr. Richard Xue has decided to leave the company due to personal reasons effective on February 17, 2014. The Company's board of directors ("Board") will conduct a search for a new CFO immediately. The Company's Financial Controller and VP of Finance, Jennifer Hu, who has been with the Company for more than 5 years, will perform all duties in accounting and finance on an interim basis, under the supervision of the Company's President, Mark Stabingas, as well as the Board's Audit Committee. "On behalf of the company, I'd like to thank Richard for his significant contributions to the Company, including a very successful IPO in 2013. We wish him the best in his future endeavors,"commented Mr. Alan Guo, Chairman and CEO of LightInTheBox. "Due to personal reasons, I need to step aside from my work at LightInTheBox. Working at LightInTheBox has been a rewarding experience and I leave the company with well wishes for my colleagues and the future development of the Company," stated Mr. Xue. About LightInTheBox Holding Co., Ltd. LightInTheBox is a global online retail company that delivers products directly to consumers around the world. The Company offers customers a convenient way to shop for a wide selection of lifestyle products at attractive prices through its www.lightinthebox.com, www.miniinthebox.com and other websites, which are available in 27 major languages and cover more than 80% of global Internet users. In 2012, the Company ranked number one in terms of revenue generated from customers outside of China among all China-based retail websites that source products from third-party manufacturers. For more information, please visit www.lightinthebox.com. Forward-Looking Statements This announcement contains forward-looking statements. These statements are made under the "safe harbor" provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "potential," "continue," "ongoing," "targets" and similar statements. Among other things, statements that are not historical facts, including statements about LightInTheBox's beliefs and expectations, the business outlook and quotations from management in this announcement, as well as LightInTheBox's strategic and operational plans, are or contain forward-looking statements. LightInTheBox may also make written or oral forward-looking statements in its periodic reports to the U.S. Securities and Exchange Commission (the "SEC"), in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Forward-looking statements involve inherent risks and uncertainties. A number of factors could cause actual results to differ materially from those contained in any forward-looking statement, including but not limited to the following: LightInTheBox's goals and strategies; LightInTheBox's future business development, results of operations and financial condition; the expected growth of the global online retail market; LightInTheBox's ability to attract customers and further enhance customer experience and product offerings; LightInTheBox's ability to strengthen its supply chain efficiency and optimize its logistics network; LightInTheBox's expectations regarding demand for and market acceptance of its products; competition; fluctuations in general economic and business conditions and assumptions underlying or related to any of the foregoing. Further information regarding these and other risks is included in LightInTheBox's filings with the SEC. All information provided in this press release and in the attachments is as of the date of this press release, and LightInTheBox does not undertake any obligation to update any forward-looking statement, except as required under applicable law. Contact: Investor Relations LightInTheBox Holding Co., Ltd. Margaret Shi, Investor Relations +86 10 5692 0099 ext 8124 email@example.com or ICR, Inc. Bill Zima, 646-405-4933 email@example.com
LightInTheBox Holding Co., Ltd. Announces Management Change
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Publications (40)393.4 Total impact
Article: How individual participant data meta-analyses have influenced trial design, conduct and analysis[Show abstract] [Hide abstract]
ABSTRACT: To demonstrate how individual participant data (IPD) meta-analyses have impacted directly on the design and conduct of trials and highlight other advantages IPD might offer.Journal of Clinical Epidemiology 06/2015; DOI:10.1016/j.jclinepi.2015.05.024 · 5.48 Impact Factor
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ABSTRACT: To evaluate the effects of administering chemotherapy following surgery, or following surgery plus radiotherapy (known as adjuvant chemotherapy) in patients with early stage non-small cell lung cancer (NSCLC),we performed two systematic reviews and meta-analyses of all randomised controlled trials using individual participant data. Results were first published in The Lancet in 2010. To compare, in terms of overall survival, time to locoregional recurrence, time to distant recurrence and recurrence-free survival:A. Surgery versus surgery plus adjuvant chemotherapyB. Surgery plus radiotherapy versus surgery plus radiotherapy plus adjuvant chemotherapyin patients with histologically diagnosed early stage NSCLC.(2)To investigate whether or not predefined patient subgroups benefit more or less from cisplatin-based chemotherapy in terms of survival. We supplemented MEDLINE and CANCERLIT searches (1995 to December 2013) with information from trial registers, handsearching relevant meeting proceedings and by discussion with trialists and organisations. We included trials of a) surgery versus surgery plus adjuvant chemotherapy; and b) surgery plus radiotherapy versus surgery plus radiotherapy plus adjuvant chemotherapy, provided that they randomised NSCLC patients using a method which precluded prior knowledge of treatment assignment. We carried out a quantitative meta-analysis using updated information from individual participants from all randomised trials. Data from all patients were sought from those responsible for the trial. We obtained updated individual participant data (IPD) on survival, and date of last follow-up, as well as details of treatment allocated, date of randomisation, age, sex, histological cell type, stage, and performance status. To avoid potential bias, we requested information for all randomised patients, including those excluded from the investigators' original analyses. We conducted all analyses on intention-to-treat on the endpoint of survival. For trials using cisplatin-based regimens, we carried out subgroup analyses by age, sex, histological cell type, tumour stage, and performance status. We identified 35 trials evaluating surgery plus adjuvant chemotherapy versus surgery alone. IPD were available for 26 of these trials and our analyses are based on 8447 participants (3323 deaths) in 34 trial comparisons. There was clear evidence of a benefit of adding chemotherapy after surgery (hazard ratio (HR)= 0.86, 95% confidence interval (CI)= 0.81 to 0.92, p< 0.0001), with an absolute increase in survival of 4% at five years.We identified 15 trials evaluating surgery plus radiotherapy plus chemotherapy versus surgery plus radiotherapy alone. IPD were available for 12 of these trials and our analyses are based on 2660 participants (1909 deaths) in 13 trial comparisons. There was also evidence of a benefit of adding chemotherapy to surgery plus radiotherapy (HR= 0.88, 95% CI= 0.81 to 0.97, p= 0.009). This represents an absolute improvement in survival of 4% at five years.For both meta-analyses, we found similar benefits for recurrence outcomes and there was little variation in effect according to the type of chemotherapy, other trial characteristics or patient subgroup.We did not undertake analysis of the effects of adjuvant chemotherapy on quality of life and adverse events. Quality of life information was not routinely collected during the trials, but where toxicity was assessed and mentioned in the publications, it was thought to be manageable. We considered the risk of bias in the included trials to be low. Results from 47 trial comparisons and 11,107 patients demonstrate the clear benefit of adjuvant chemotherapy for these patients, irrespective of whether chemotherapy was given in addition to surgery or surgery plus radiotherapy. This is the most up-to-date and complete systematic review and individual participant data (IPD) meta-analysis that has been carried out.Cochrane database of systematic reviews (Online) 03/2015; 3:CD011430. DOI:10.1002/14651858.CD011430 · 5.94 Impact Factor
Article: Should Tyrosine Kinase Inhibitors Be Considered for Advanced Non–Small-Cell Lung Cancer Patients With Wild Type EGFR? Two Systematic Reviews and Meta-Analyses of Randomized Trials[Show abstract] [Hide abstract]
ABSTRACT: Guidance concerning TKIs for patients with wild-type EGFR and advanced non-small cell lung cancer (NSCLC) following first-line treatment is unclear.Materials and Methods We assessed the effect of TKIs as second-line therapy and maintenance therapy following first-line chemotherapy in two systematic reviews and meta-analyses, focusing on patients without EGFR mutations. Systematic searches were completed and data extracted from eligible RCTs. Three analytical approaches were used to maximise available data.ResultsFourteen trials of second-line treatment (4388 patients) were included. Results showed the effect of TKIs on progression-free survival (PFS) depended on EGFR status (interaction HR=2·69, p=0·004). Chemotherapy benefitted patients with wild-type EGFR (HR=1.31, p<0·0001), TKIs benefitted patients with mutations (HR=0·34, p=0·0002). Based on 12 trials (85% of randomised patients) the benefits of TKIs on PFS decreased with increasing proportions of patients with wild-type EGFR (p=0.014). Six trials of maintenance therapy (2697 patients) were included. Results showed that whilst the effect of TKIs on PFS depended on EGFR status (interaction HR=3.58, p<0·0001), all benefitted from TKIs (wild-type EGFR: HR=0.82, p=0.01; mutated EGFR: HR=0.24, p<0·0001). There was a suggestion that benefits of TKIs on PFS decreased with increasing proportions of patients with wild-type EGFR (p=0.11).Conclusions Chemotherapy should be standard second-line treatment for patients with advanced NSCLC and wild-type EGFR. TKIs may be unsuitable for unselected patients. TKIs appear to benefit all patients when compared with no active treatment as maintenance treatment, however direct comparisons with chemotherapy are needed.Clinical Lung Cancer 11/2014; 16(3). DOI:10.1016/j.cllc.2014.11.007 · 3.22 Impact Factor
- The Lancet 07/2014; 384(9939):233. DOI:10.1016/S0140-6736(14)61209-5 · 45.22 Impact Factor
Article: Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data[Show abstract] [Hide abstract]
ABSTRACT: Background The gold standard endpoint in clinical trials of chemotherapy and radiotherapy for lung cancer is overall survival. Although reliable and simple to measure, this endpoint takes years to observe. Surrogate endpoints that would enable earlier assessments of treatment effects would be useful. We assessed the correlations between potential surrogate endpoints and overall survival at individual and trial levels. Methods We analysed individual patients' data from 15 071 patients involved in 60 randomised clinical trials that were assessed in six meta-analyses. Two meta-analyses were of adjuvant chemotherapy in non-small-cell lung cancer, three were of sequential or concurrent chemotherapy, and one was of modified radiotherapy in locally advanced lung cancer. We investigated disease-free survival (DFS) or progression-free survival (PFS), defined as the time from randomisation to local or distant relapse or death, and locoregional control, defined as the time to the first local event, as potential surrogate endpoints. At the individual level we calculated the squared correlations between distributions of these three endpoints and overall survival, and at the trial level we calculated the squared correlation between treatment effects for endpoints. Findings In trials of adjuvant chemotherapy, correlations between DFS and overall survival were very good at the individual level (ρ2=0·83, 95% CI 0·83–0·83 in trials without radiotherapy, and 0·87, 0·87–0·87 in trials with radiotherapy) and excellent at trial level (R2=0·92, 95% CI 0·88–0·95 in trials without radiotherapy and 0·99, 0·98–1·00 in trials with radiotherapy). In studies of locally advanced disease, correlations between PFS and overall survival were very good at the individual level (ρ2 range 0·77–0·85, dependent on the regimen being assessed) and trial level (R2 range 0·89–0·97). In studies with data on locoregional control, individual-level correlations were good (ρ2=0·71, 95% CI 0·71–0·71 for concurrent chemotherapy and ρ2=0·61, 0·61–0·61 for modified vs standard radiotherapy) and trial-level correlations very good (R2=0·85, 95% CI 0·77–0·92 for concurrent chemotherapy and R2=0·95, 0·91–0·98 for modified vs standard radiotherapy). Interpretation We found a high level of evidence that DFS is a valid surrogate endpoint for overall survival in studies of adjuvant chemotherapy involving patients with non-small-cell lung cancers, and PFS in those of chemotherapy and radiotherapy for patients with locally advanced lung cancers. Extrapolation to targeted agents, however, is not automatically warranted. Funding Programme Hospitalier de Recherche Clinique, Ligue Nationale Contre le Cancer, British Medical Research Council, Sanofi-Aventis.The Lancet Oncology 06/2013; 14(7):619–626. DOI:10.1016/S1470-2045(13)70158-X · 24.73 Impact Factor
Article: Can trial quality be reliably assessed from published reports of cancer trials: evaluation of risk of bias assessments in systematic reviews.[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the reliability of risk of bias assessments based on published trial reports, for determining trial inclusion in meta-analyses. Reliability evaluation of risk of bias assessments. DATA SOURCES : 13 published individual participant data (IPD) meta-analyses in cancer were used to source 95 randomised controlled trials. REVIEW METHODS : Risk of bias was assessed using the Cochrane risk of bias tool (RevMan5.1) and accompanying guidance. Assessments were made for individual risk of bias domains and overall for each trial, using information from either trial reports alone or trial reports with additional information collected for IPD meta-analyses. Percentage agreements were calculated for individual domains and overall (<66%=low, ≥66%=fair, ≥90%=good). The two approaches were considered similarly reliable only when agreement was good. Percentage agreement between the two methods for sequence generation and incomplete outcome data was fair (69.5% (95% confidence interval 60.2% to 78.7%) and 80.0% (72.0% to 88.0%), respectively). However, percentage agreement was low for allocation concealment, selective outcome reporting, and overall risk of bias (48.4% (38.4% to 58.5%), 42.1% (32.2% to 52.0%), and 54.7% (44.7% to 64.7%), respectively). Supplementary information reduced the proportion of unclear assessments for all individual domains, consequently increasing the number of trials assessed as low risk of bias (and therefore available for inclusion in meta-analyses) from 23 (23%) based on publications alone to 66 (66%) based on publications with additional information. Using cancer trial publications alone to assess risk of bias could be unreliable; thus, reviewers should be cautious about using them as a basis for trial inclusion, particularly for those trials assessed as unclear risk. Supplementary information from trialists should be sought to enable appropriate assessments and potentially reduce or overcome some risks of bias. Furthermore, guidance should ensure clarity on what constitutes risk of bias, particularly for the more subjective domains.BMJ (online) 04/2013; 346:f1798. DOI:10.1136/bmj.f1798 · 16.38 Impact Factor
Article: A closer look at the effects of postoperative radiotherapy by stage and nodal status: Updated results of an individual participant data meta-analysis in non-small-cell lung cancerLung cancer (Amsterdam, Netherlands) 02/2013; 80(3). DOI:10.1016/j.lungcan.2013.02.005 · 3.74 Impact Factor
Article: Response to: Practical methods for incorporating summary time-to-event data into meta. Authors' reply.Trials 01/2013; 14:391. · 2.12 Impact Factor
Article: Assessing and improving the reliability of meta-analyses of hazard ratios derived from published time-to-event dataTrials 01/2013; 14(Suppl 1):O93. DOI:10.1186/1745-6215-14-S1-O93 · 2.12 Impact Factor
Article: A systematic search for reports of site monitoring technique comparisons in clinical trials[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: As part of a broader methodological programme of work around clinical trial monitoring, we wanted to evaluate the existing evidence for the effectiveness of different monitoring techniques. PURPOSE: To identify and evaluate prospective studies of the effectiveness of different monitoring strategies. METHODS: A systematic search of MEDLINE from 1950 onwards, using free-text terms to identify relevant published studies. We intended to extract data on details of comparative techniques, monitoring findings identified by different techniques, and recommendations or identification of areas in need of further research made by authors. RESULTS: A total of 1222 published abstracts were identified and reviewed. Of these, nine articles described methods for quality control (QC) of clinical trial activities, and one article was identified that compared the same monitoring technique at two timepoints. None included a direct comparison of different monitoring techniques and findings. LIMITATIONS: The search strategy was limited to MEDLINE. However, MEDLINE includes all the journals that tend to report trial methodological research. CONCLUSIONS: There is a lack of published empirical data that compare monitoring strategies prospectively. Assessment of the usefulness and cost-effectiveness of monitoring techniques in a variety of clinical trial settings and indications is needed. Clinical Trials 2012; 0: 1-4 http://ctj.sagepub.com.Clinical Trials 10/2012; 9(6). DOI:10.1177/1740774512458993 · 1.94 Impact Factor
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ABSTRACT: Aspirin inhibits the enzyme cyclooxygenase (Cox), and there is a significant body of epidemiological evidence demonstrating that regular aspirin use is associated with a decreased incidence of developing cancer. Interest focussed on selective Cox-2 inhibitors both as cancer prevention agents and as therapeutic agents in patients with proven malignancy until concerns were raised about their toxicity profile. Aspirin has several additional mechanisms of action that may contribute to its anti-cancer effect. It also influences cellular processes such as apoptosis and angiogenesis that are crucial for the development and growth of malignancies. Evidence suggests that these effects can occur through Cox-independent pathways questioning the rationale of focussing on Cox-2 inhibition alone as an anti-cancer strategy. Randomised studies with aspirin primarily designed to prevent cardiovascular disease have demonstrated a reduction in cancer deaths with long-term follow-up. Concerns about toxicity, particularly serious haemorrhage, have limited the use of aspirin as a cancer prevention agent, but recent epidemiological evidence demonstrating regular aspirin use after a diagnosis of cancer improves outcomes suggests that it may have a role in the adjuvant setting where the risk:benefit ratio will be different.British Journal of Cancer 08/2011; 105(8):1107-13. DOI:10.1038/bjc.2011.289 · 4.82 Impact Factor
Article: Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics.[Show abstract] [Hide abstract]
ABSTRACT: Clinical researchers have often preferred to use a fixed effects model for the primary interpretation of a meta-analysis. Heterogeneity is usually assessed via the well known Q and I2 statistics, along with the random effects estimate they imply. In recent years, alternative methods for quantifying heterogeneity have been proposed, that are based on a 'generalised' Q statistic. We review 18 IPD meta-analyses of RCTs into treatments for cancer, in order to quantify the amount of heterogeneity present and also to discuss practical methods for explaining heterogeneity. Differing results were obtained when the standard Q and I2 statistics were used to test for the presence of heterogeneity. The two meta-analyses with the largest amount of heterogeneity were investigated further, and on inspection the straightforward application of a random effects model was not deemed appropriate. Compared to the standard Q statistic, the generalised Q statistic provided a more accurate platform for estimating the amount of heterogeneity in the 18 meta-analyses. Explaining heterogeneity via the pre-specification of trial subgroups, graphical diagnostic tools and sensitivity analyses produced a more desirable outcome than an automatic application of the random effects model. Generalised Q statistic methods for quantifying and adjusting for heterogeneity should be incorporated as standard into statistical software. Software is provided to help achieve this aim.BMC Medical Research Methodology 01/2011; 11:41. DOI:10.1186/1471-2288-11-41 · 2.17 Impact Factor
Article: Meta-Analysis of Concomitant Versus Sequential Radiochemotherapy in Locally Advanced Non-Small-Cell Lung Cancer[Show abstract] [Hide abstract]
ABSTRACT: The previous individual patient data meta-analyses of chemotherapy in locally advanced non-small-cell lung cancer (NSCLC) showed that adding sequential or concomitant chemotherapy to radiotherapy improved survival. The NSCLC Collaborative Group performed a meta-analysis of randomized trials directly comparing concomitant versus sequential radiochemotherapy. Systematic searches for trials were undertaken, followed by central collection, checking, and reanalysis of updated individual patient data. Results from trials were combined using the stratified log-rank test to calculate pooled hazard ratios (HRs). The primary outcome was overall survival; secondary outcomes were progression-free survival, cumulative incidences of locoregional and distant progression, and acute toxicity. Of seven eligible trials, data from six trials were received (1,205 patients, 92% of all randomly assigned patients). Median follow-up was 6 years. There was a significant benefit of concomitant radiochemotherapy on overall survival (HR, 0.84; 95% CI, 0.74 to 0.95; P = .004), with an absolute benefit of 5.7% (from 18.1% to 23.8%) at 3 years and 4.5% at 5 years. For progression-free survival, the HR was 0.90 (95% CI, 0.79 to 1.01; P = .07). Concomitant treatment decreased locoregional progression (HR, 0.77; 95% CI, 0.62 to 0.95; P = .01); its effect was not different from that of sequential treatment on distant progression (HR, 1.04; 95% CI, 0.86 to 1.25; P = .69). Concomitant radiochemotherapy increased acute esophageal toxicity (grade 3-4) from 4% to 18% with a relative risk of 4.9 (95% CI, 3.1 to 7.8; P < .001). There was no significant difference regarding acute pulmonary toxicity. Concomitant radiochemotherapy, as compared with sequential radiochemotherapy, improved survival of patients with locally advanced NSCLC, primarily because of a better locoregional control, but at the cost of manageable increased acute esophageal toxicity.Journal of Clinical Oncology 03/2010; 28(13):2181-90. DOI:10.1200/JCO.2009.26.2543 · 17.88 Impact Factor
Article: Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data[Show abstract] [Hide abstract]
ABSTRACT: SummaryBackground Many randomised controlled trials have investigated the effect of adjuvant chemotherapy in operable non-small-cell lung cancer. We undertook two comprehensive systematic reviews and meta-analyses to establish the effects of adding adjuvant chemotherapy to surgery, or to surgery plus radiotherapy.Methods We included randomised trials, not confounded by additional therapeutic differences between the two groups and that started randomisation on or after Jan 1, 1965, which compared surgery plus adjuvant chemotherapy versus surgery alone, or surgery plus adjuvant radiotherapy and chemotherapy versus surgery plus adjuvant radiotherapy. Updated individual patient data were collected, checked, and included in meta-analyses stratified by trial. The primary endpoint was overall survival, defined as time from randomisation until death by any cause. All analyses were by intention to treat.Findings The first meta-analysis of surgery plus chemotherapy versus surgery alone was based on 34 trial comparisons and 8447 patients (3323 deaths). We recorded a benefit of adding chemotherapy after surgery (hazard ratio [HR] 0·86, 95% CI 0·81-0·92, p<0·0001), with an absolute increase in survival of 4% (95% CI 3-6) at 5 years (from 60% to 64%). The second meta-analysis of surgery plus radiotherapy and chemotherapy versus surgery plus radiotherapy was based on 13 trial comparisons and 2660 patients (1909 deaths). We recorded a benefit of adding chemotherapy to surgery plus radiotherapy (HR 0·88, 95% CI 0·81-0·97, p=0·009), representing an absolute improvement in survival of 4% (95% CI 1-8) at 5 years (from 29% to 33%). In both meta-analyses we noted little variation in effect according to the type of chemotherapy, other trial characteristics, or patient subgroup.Interpretation The addition of adjuvant chemotherapy after surgery for patients with operable non-small-cell lung cancer improves survival, irrespective of whether chemotherapy was adjuvant to surgery alone or adjuvant to surgery plus radiotherapy.FundingThe Lancet 01/2010; 375(9722):1267-1277. DOI:10.1016/S0140-6736(10)60059-1 · 45.22 Impact Factor
Article: Why i.p. therapy cannot yet be considered as a standard of care for the first-line treatment of ovarian cancer: a systematic review[Show abstract] [Hide abstract]
ABSTRACT: A National Cancer Institute (NCI) clinical announcement recommended i.p. therapy for women with optimally debulked ovarian cancer. Its basis was a summary of eight randomised controlled trials and two systematic reviews, which appear to indicate benefit of i.p. therapy. However, the systematic reviews that inform the recommendations have been inappropriately presented and interpreted. The systematic reviews inappropriately pooled results from 'confounded' trials in which different drugs and different doses of drugs were given in the control and i.p. treatment arms. Therefore, it is not possible to assess which component of treatment is responsible for improving outcome. In addition, none of the trials use a control arm of the internationally accepted standard of care. Using just the unconfounded trials, indirect comparisons show that the magnitude of benefit observed when i.p. regimens are compared with older i.v. regimens [hazard ratio (HR) for overall survival (OS) 0.75; 95% confidence interval (CI) 0.60-0.92, P = 0.006] is smaller than the magnitude of benefit achieved with modern day standard of i.v. treatment compared with the same i.v. regimen used as control in the unconfounded i.p. trials (HR for OS 0.68; 95% CI 0.58-0.80, P < 0.001). A further difficulty is that the reviews cannot recommend an i.p. regimen for standard use. Drug-related toxicity and catheter complications that occur with i.p. therapy are considerable. The NCI recommendations have major implications for the treatment of women with ovarian cancer and for the next generation of clinical trials. We do not believe that the body of evidence currently available supports the recommendation that i.p. therapy should form part of routine care. The choice of treatment of women with newly diagnosed, optimally debulked, ovarian cancer, where therapy has the best chance of influencing OS, is too important to be left with this uncertainty. A clinical trial that investigates a practical and acceptable regimen which gives some or all chemotherapy by the i.p. route and compares this with standard i.v. chemotherapy should be a priority for those who wish to promote its use.Annals of Oncology 04/2008; 19(4):688-95. DOI:10.1093/annonc/mdm518 · 6.58 Impact Factor
Article: Chemotherapy in addition to supportive care improves survival in advanced non-small cell lung cancer: A systematic review and meta-analysis of individual patient data from 16 randomised controlled trials. NSCLC Meta-analyses Collaborative Group
Article: Supportive care and chemotherapy (CT) versus supportive care alone in advanced non-small cell lung cancer (NSCLC): A meta-analysis using individual patient data (IPD) from randomised controlled trials (RCTs): B2-03Journal of Thoracic Oncology 08/2007; 2(8). DOI:10.1097/01.JTO.0000283148.83670.80 · 5.80 Impact Factor
Article: Chemotherapy (CT) in addition to surgery or surgery plus radiotherapy (RT) in non-small cell lung cancer (NSCLC): Two meta-analyses using individual patient data (IPD) from randomised controlled trials (RCTs): C3-05Journal of Thoracic Oncology 08/2007; 2(8). DOI:10.1097/01.JTO.0000283206.02319.bf · 5.80 Impact Factor
Article: Sequential radio-chemotherapy (RT-CT) versus radiotherapy alone (RT) and concomitant RT-CT versus RT alone in locally advanced non-small cell lung cancer (NSCLC): Two meta-analyses using individual patient data (IPD) from randomised clinical trials (RCTs): A1-04[Show abstract] [Hide abstract]
ABSTRACT: An abstract is unavailable. This article is available as HTML full text and PDF.Journal of Thoracic Oncology 07/2007; 2(8):S309-S310. DOI:10.1097/01.JTO.0000283093.09465.20 · 5.80 Impact Factor
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ABSTRACT: In systematic reviews and meta-analyses, time-to-event outcomes are most appropriately analysed using hazard ratios (HRs). In the absence of individual patient data (IPD), methods are available to obtain HRs and/or associated statistics by carefully manipulating published or other summary data. Awareness and adoption of these methods is somewhat limited, perhaps because they are published in the statistical literature using statistical notation. This paper aims to 'translate' the methods for estimating a HR and associated statistics from published time-to-event-analyses into less statistical and more practical guidance and provide a corresponding, easy-to-use calculations spreadsheet, to facilitate the computational aspects. A wider audience should be able to understand published time-to-event data in individual trial reports and use it more appropriately in meta-analysis. When faced with particular circumstances, readers can refer to the relevant sections of the paper. The spreadsheet can be used to assist them in carrying out the calculations. The methods cannot circumvent the potential biases associated with relying on published data for systematic reviews and meta-analysis. However, this practical guide should improve the quality of the analysis and subsequent interpretation of systematic reviews and meta-analyses that include time-to-event outcomes.Trials 02/2007; 8(1):16. DOI:10.1186/1745-6215-8-16 · 2.12 Impact Factor
Top Journals
Mrc HarwellOxford, England, United Kingdom
Duke UniversityDurham, North Carolina, United States
University of Leicester
Leiscester, England, United Kingdom
- Department of Health Sciences
Medical Research Council (UK)
Londinium, England, United Kingdom
- MRC Clinical Trials Unit
Centre Hospitalier Régional Universitaire de LilleLille, Nord-Pas-de-Calais, France
Institut de Cancérologie Gustave Roussy
Villejuif, Ile-de-France, France
- Department of Public Health


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A small town with a big history.
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The following events take place regularly throughout the month of July on the days and times listed.
Fourth of July Car Cruise Saturday, July 4, 2015 Starts at Fairhaven High School, 12 Huttleston
Fort Phoenix Independence Day Ceremony and Cannon Salute Saturday, July 4, 2015, 10:00 a.m. Fort
141 Main St Fairhaven MA 02719
Hours: Mon, Tu, Thu, Fri, Sat
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Lakefield is a quiet secluded site set in five acres on the north coast of Cornwall with its own lake and valley views on a 54-acre small holding. A quiet family site with no pubs or clubs, at Lakefield when it's dark, it really is dark, and on a clear night the stars are amazing!
The site has well spaced pitches on grass, some of them offering electric 16-amp hook-up.
We have a well-maintained, recently modernised toilet block with free hot showers and free hot water. There is also a washing machine and a tumble dryer within the toilet block. In reception we sell the basics - milk, bread and eggs.
There is a large area left free for children to play ball games which is within easy sight of most pitches. Dogs are welcome and a large field is provided for dogs to have off-lead exercise.
Lakefield also boasts a BHS/RDA-approved equestrian centre separate from the site which offers lessons and hacks to all ages and abilities.
Despite our secluded location, we are conveniently situated on a B road and make an excellent base for exploring the north coast.
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Languages spoken
✓ English
Check availability at Lakefield Caravan Park…
(2 nights)
Party:2 adults
You can now make a booking for up to 30 adults and 30 children on Pitchup.com.
Many sites set a maximum occupancy of 6/8 people per pitch, so try breaking your booking down into smaller groups to generate more results. For example, if you're a group of 10, enter 5 people in your initial search and then book 2 pitches.
Use the 'Special requests' box on the booking page to ask to be sited together when booking multiple pitches: the campsite or park will try to grant your request.
Large groups: check the listing page for any group restrictions set out in the terms and section titled 'Please note'.
Large tents/caravans: check the restrictions on unit dimensions to ensure your unit is suitable for the space you will be provided with.
Max. persons: 6x
Dimensions: Max 10.0m x 15.0m (32.8ft x 49.2ft)
Ground type: Grass
The pitch has a hedge on one side.
Only one car is to be parked by the pitch. Extra cars must be parked in the designated area.
Max. persons: 6x
Dimensions: Max 10.0m x 15.0m (32.8ft x 49.2ft)
Ground type: Grass
Only one car is to be parked by the pitch. Extra cars must be parked in the designated area.


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NME.COM artist profile on Chvrches including news, reviews, videos, photos, gigs, tickets and more.
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Chvrches discuss 'emosh' second album material
The band have finished recording the follow-up to 2013 debut 'The Bones Of What You Believe'
- Jun 22, 2015
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Chvrches - 'The Bones Of What You Believe'
- Sep 20, 2013
Chvrches - 'Recover EP'
- Mar 22, 2013


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The Ten Best Grunge Bands
A couple of weeks ago, Pearl Jam played the American Airlines Center and rocked the hell out of the place. But after all of these years, can anyone still call Pearl Jam a grunge band? As someone who was in college when the grunge sound came wallowing out of Seattle, I can attest to the greatest of much of the music and the ridiculousness of seeing so many guys wearing flannel. But as guitars get more and more scarce on the Billboard Hot 100, we pine for distortion more and more. In tribute to what may prove one of the last great rock movements, we offer our ten favorite grunge bands.
10. Pearl Jam From the beginning, Eddie Vedder and crew had a very tangential connection to the grunge scene and the grunge sound. Sure, bassist Jeff Ament and guitarist Stone Gossard served time in two real grunge bands, Green River and Mother Love Bone, but Vedder's presence was always that of a rock god, a far cry from every other front man. And exactly what albums from Pearl Jam can really be considered grunge? Maybe 1993's Vs. For strictly sentimental reasons, Pearl Jam hits the list at number ten.
9. Mother Love Bone Basically Pearl Jam before Vedder. Sadly, singer Andrew Wood died just months before the band's debut album, Apple, was released. The album featured some good songs, but pointed to the corporate leanings that would define Pearl Jam.
8. Tad Led by the magnificently rotund Tad Doyle, the band Tad was a chaotic, Black Sabbath-inspired mess. Most importantly, these guys defined the grunge aesthetic: they were ugly and they didn't give a shit.
7. L7 Hailing out of Los Angeles, this all female band became grunge by association. Although their music was based more in old school punk and metal, L7 looked grungy. Plus, they had the best album title of the scene: 1992's Bricks are Heavy.
6. The Melvins Definitely the heaviest of all the bands associated with the grunge scene, The Melvins also rivaled Tad in the ugly department. But my contention has always been the least attractive bands make the best music. Buzz Osborne and crew are still slinging the sludge some three decades after the fact.
5. Soundgarden Fronted by the hunk known as Chris Cornell, Soundgarden began life as a legitimate grunge act. The band's 1988 debut, Ultramega OK, was one of the defining releases on Sub Pop, the defacto grunge label. But slowly, popularity morphed Soundgarden into a slightly better than average, run of the mill rock act.
4. Screaming Trees Singer Mark Lanegan may well have been grunge's best front man. By far the most consistent songwriter the movement ever produced, Lanegan is still making great music today. In their prime, Screaming Trees were one powerful unit. Not even signing to a major label in 1990 dulled their edge. They are a band well worth re-investigating.
3. Green River Sort of the holy grail of the grunge scene, Green River, while never nationally popular, were still hugely influential. Led by the terrifically untalented Mark Arm, Green River's sole album and two EPs are the grunge real deal. "Good things come to those who wait," sings Arm on "Searchin'", "So I want to come."
2. Nirvana Too much has already been written about Nirvana, but I always loved seeing Cobain wearing that "Corporate Rock Sucks" t-shirt.
1. Mudhoney After Green River, Mark Arm assembled Mudhoney and the band has been pushing out quality grunge since 1988. Remarkably, this year brought Vanishing Point, a signature statement from what may well prove to be the last grunge band standing.
See also: -The Top Ten All Time Best Replacement Lead Singers in Rock and Roll -Songs That Have Hidden Messages When Played in Reverse -The Ten Best Music Videos Banned by MTV
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Thank you to all who participated and helped to make our 2015 Craven Jaguar Summer Football Camp a success!
The start of our regular season is just around the corner. If you have not registered your player, today is the day.
REGISTRATION for our 2015 Football & Cheer Season is here.
Hurry and register today! Registering your player/cheerleader early guarantees him/her a spot on a Craven Jaguar team. The regular season begins July 27, 2015 and ends in November 2015. Games are on Saturdays, beginning August 29th with all teams having a bye on Labor Day Weekend. Home games are played at our home site, West Craven Park. Fall Football registration fee is $90 for the first football player, $75 for the second player from the same family and $60 for the third and subsequent players.Registration fee is $60 per cheerleader. Subsequent cheerleaders from the same family may register for $55.Our Early Bird registration fees are $10 off your first football registration fee and/or $5 off your first cheer registration fee. Early Bird fees must be paid in full before July 1, 2015. Early bird fees not paid in full by this time will be subject to the full fee.Players must obtain a recent physical by the end July. Certification is scheduled for the first of August. If you are interested in signing up for a physical from one of our medical volunteers, send an email to: email@example.com. An onsite physical date during the last week of July will be a one time offering. Sponsorships are vital for a successful Season! The Sponsorship Search for the 2015 Season is underway. Anyone who is interested in assisting with our search committee, knows of a company that may be interested or would like additional information, please contact Tammy, at firstname.lastname@example.com. For registration questions, email Dena, Loretta or Hermione at firstname.lastname@example.com.
Download the forms by clicking our registration link or click: https://active.leagueone.com/olr/pages/welcome.aspx?clubid=12771 to register.
Craven Jaguars Board of Directors
July 27th - July 30th, 6:30 - 8 pm at Creekside Pavilion soccer fields.
Free to Registered Regular Season Cheerleaders. $20 if registering for cheer camp only, ages 5-15
Mandatory for ALL regular season registered cheerleaders. Last day to register and pay for regular season cheer August 11th.
Regular season cheerleaders are required to purchase: briefs and bow from the Craven Jaguar Team Apparel website at New Bern Sporting Goods.
Questions contact Jennifer DeCamp at:
Conditioning sessions geared to acclimate athletes to the summer heat begin on Tuesday, July 7th at 6 pm at Creekside Park Pavilion upfront and continues on Tuesday's and Thursday's evenings in July thru 23rd. Sessions are free and open to all. Please bring a filled water bottle with your name clearly marked. Dress for the heat: tee, shorts and cleats or sneakers. Be sure to hydrate prior to coming out. Enjoy as many sessions as you are able to attend.
Online Registration continues. There will also be Registration folks on site periodically on some evenings during conditioning if you need assistance.
Our league has implemented a certification process that includes NC DMV ID cards. The Craven Jaguars requires all 15U, 12U, 10U, 8U & 6U players to obtain a NC DMV ID card for the 2015 Season. Military IDs are accepted. IDs are not required to start the practice season on July 27th. There is a 2 week turn around for ID cards. No player will be able to play in games without an ID card. This process aids in ensuring proper uniformity with certification for all associations within our league. Another advantage of using ID cards is the safety factor. Should a child ever get lost, all the identifying information on the ID card can be in any police car & Amber alert system in America in less than 2 minutes!To obtain an ID card, you can set up an appointment or drop by one of the below locations.
New Bern Kinston Havelock
2106 Neuse Blvd. 2214 W. Vernon Ave 300 Miller Road
DMV Building DMV Building Old Library Building
New Bern, NC 28560 Kinston, NC 28501 Havelock, NC 28532
252-514-4734 252-526-4432 252-44406425
Mobile Unit
13451 Hwy 55
Bayboro, NC 28515
Take the following documents and fees:
$10 cashCertified Copy of Birth CertificateOriginal Social Security CardReport Card or Bank Statement with child's name and address(If you don't have last item, DMV will charge $2 more and let you sign affidavit for address)Parents don't have to be present, players can go with any adult to DMV with required documentation to obtain ID, in groups of up to 6. The ID is good for 8 years.
CONGRATULATIONS CRAVEN JAGUARS on your nomination for 2014 Organization of the year and
for the 6U nomination for 2014 Team of the Year by Mid-Atlantic NPFA!
Official results can be found on the CCAYFL website.
Congratulations to the Craven Jaguars 12U for qualifying for the 2014 Super Bowl
Congratulations to the Craven Jaguars 12U for their outstanding performance at the 2014 Civitan Turkey Bowl in Clayton, NC, Nov 2014
Congratulations to the Craven Jaguars 6U, "2014 National Prep Youth Football Association Champions" VA, Dec 14
Congratulations to the Craven Jaguars 10U for their outstanding performance at National Prep Youth Football Association VA, Dec 14
Our organization strives to make every effort to ensure that any child with the desire to participate gets the opportunity to play, without regard to weight, race, economic status, prior experience, or athletic ability!
We are committed to promoting & instilling Honesty, Loyalty, Integrity, Teamwork, Discipline, Sportsmanship, Respect, Leadership, Trust, and Commitment in our young participants. We believe these values and virtues are important to their growth and to becoming productive members of our community and society.
We will instill in our youth the challenge of competition, the joy of victory, the reality of defeat, the importance of commitment, and the spirit of community. The Craven Jaguars emphasize the importance of academic achievement among athletes and aim to recognize those with exemplary athletic performance while achieving academic success; and by doing so, prepare our young athletes for the challenges of high school and collegiate environments.
Achieve our objectives through organizing our dedicated volunteers, caring parents, and business associates who wish to partner with our superb youth sports programs.
I. To provide a wholesome competitiveness within the scope of our rules and regulations while cultivating values intrinsic to football and preparing players for life.II. To teach the proper techniques and fundamentals of football while instilling a knowledge and appreciation for the game.III. To provide a responsible football program that stimulates community interest for football where players develop athletic skill and character through hard work, courage, dedication and perseverance.IV. To promote good sportsmanship, teamwork, highest morale, physical standards, a strong work ethic, and the importance of academic achievement.V. To make Youth Football ALL-INCLUSIVE by not excluding participants based on superficial factors (such as weight).
We are a non-profit, youth football association located in the Craven County - New Bern, Bridgeton, James City, Pollocksville, Havelock areas. We offer a competitive and structured youth football league for kids ages 4-15.Season starts end of July and finishes by mid-November.Games are usually played on Saturdays.Age as of July 31stDIVISION - AGE
Div AB, Anklebiters: 6 and under (4,5,6)
Div 1: 8U (6,7,8)
Div 2: 10U (8,9,10) Div 3: 12U (10,11,12) Div 4: 15U (12,13,14,15) No child will be turned away due to weight or athletic ability!FOOTBALL size8U - K210U - TDJ or equivalent12U - TDJ or TDY14U - TDY or equivalent
We want to be the most user-friendly youth sports organization in Eastern North Carolina. We need your help!


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We are a company dedicated to providing alternatives of sound and lighting for all types of events.
With years of experience, every day offering our customers an excellent service of Disc Jockey for your party or private event.
If you are looking for excellent service, with better sound quality and ensure an unforgettable night Look No further! With years of experience in this area, we know very well what we do and every day we seek to achieve new goals so bring the best DJ service.
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Our People
Ian Bartholomew
Managing Director
Ian joined Monarch in 2003 as Marketing Sales Manager and progressed to Head of Sales and Marketing before being promoted to the board of Monarch Aircraft Engineering. With responsibility for directing the sales and marketing department, including the acquisition of new business, all commercial contracts and supply chain activities comprising technical procurement and warehousing and logistics, Ian is also responsible for the Monarch Aircraft Engineering Training Academy (MAETA). In August 2014, Ian was appointed Interim Managing Director of Monarch Aircraft Engineering, taking his place on the Group Executive Committee.
With over 25 years' experience in the aircraft maintenance, repair and overhaul industry (MRO) Ian has previously been involved in leading large business transformation projects within the MRO sector and held senior commercial management positions at Air UK and KLM UK Engineering, where he was managing large teams responsible for major commercial contracts, purchasing and logistics both within the UK and the Netherlands.
Ian is also a member of the Institute of Directors and Chartered Institute of Purchasing and Supply and holds formal management qualifications.
Derek Gibson
Commercial Director
Derek began his career as an apprentice with Monarch in 1981 and worked as an aircraft engineer on the Monarch fleet until 1987.
He then took up several sales roles outside of the aviation sector before returning to Monarch in 1991 as a Sales Engineer, moving to a more senior sales role until joining KLM UK as Head of Engineering Marketing and Sales between 1996 and 1999.
He returned to Monarch as Sales and Marketing Manager and in 2003 was promoted to his first Director's role, where he had responsibility for logistics, procurement, sales and customer service. 2006 saw him take on the position of Operations Director alongside his other responsibilities with sister company Monarch Technical Support before his role was expanded to cover the leadership and development of the sales division by becoming Sales and Marketing Director.
Derek then took his breadth of experience to the role of Maintenance and Operations Director in 2010, a role which was enhanced to Compliance and Service Delivery Director. In 2014 Derek was appointed Commercial Director with overall responsibility for procurement, supply chain and repair management including the sales and customer experience departments allowing for great influence in delivering the exceptional customer service Monarch are rightly known to provide.
Keith Earnden
Engineering and Maintenance Director
Keith joined Monarch in December 2010 taking on responsibility for the management of Continuing Airworthiness activities undertaken by Monarch's Technical Services and Planning functions. He was also responsible for the management of the EASA Part 21J Design Services team within the business.
Prior to joining Monarch, Keith was with Cobham Aviation Services (FR Aviation), where he spent 6 years initially as Contract Manager at RAF Waddington before taking on the role of Engineering Director in 2007 responsible for Line and Base maintenance for a fleet of 26 aircraft. Before his time at Cobham Aviation Services, Keith also spent 2 years as Director of Engineering at Emerald Airways Engineering as well as over 20 years as an Engineer with the RAF.
In February 2014 Keith took an additional role as Continued Airworthiness Management Director for Monarch Airlines having previously been the deputy for this position. More recently following changes across the Monarch Group, he has been appointed Engineering and Maintenance Director. In this key role Keith will be responsible for all of Monarch Aircraft Engineering's service delivery and operational support areas including Line and Base Maintenance, Technical Services, Design Services and, Monarch Aircraft Engineering Training Academy (MAETA).


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Millennium Gloucester Hotel, London, UK
Download the Agenda
Register by Friday, July 10, 2015 and receive up to £400 off!
"Really valuable, I met some useful contacts and it definitely gave me additional energy to pursue new ideas that I could now see worked" Head of Client Experience, Coutts
"Extremely valuable in gaining insights and inspiration alongside consideration for prospective suppliers" Analytics and Conversion Director, Aldermore
"Very inspiring and provided me with useful information from different areas - both business views and technology views. Great to have experiences direct from the front line" Chief Project Officer, Nordea Bank
Wouldn't you want to see 90% of your customers feeling this way every time they put the phone down after speaking with your call centre or after leaving your high street branch? The majority of customer complaints happen due to lack of customer love and appreciation, being mis-sold or misheard, or simply when your customers cannot find the information they need. It's your job to know what each one of your customers thinks about your brand. It's your job to care about each one of them. We agree that can be tough when there is only you, with so many people to look after. However, you are not alone! Find out more about the unrivaled networking opportunities at CX FS 2015.
***Special offer***
'2 for 1' ticket offer for the next 13 registrants
>>> Register Here
1. This is not your typical event! If you don't want to sit through all the presentations you are welcome to stay back in our 'networking lounge' and build your onsite experience around discussions with over 130+ potential senior marketing and customer experience influencers from the financial sector and beyond.
2. We are not going to bore you with the presentations but really get you to brainstorm and think outside the box. We want you to look at this meeting as an idea generator for you to review you 2015 results and set goals for 2016. We have specifically selected some of the most charismatic speakers from the industry to guide you on your "BIG IDEA" journey.
3. Your CXFS experience starts months before the event itself as we keep you updated with the most exciting industry trends by revealing some killer content pieces form primary sources and share serious insider interviews.
4. Because we care! We will provide you with so much more than just another event for customer experience management. You will have a chance to feed your challenges and questions that keep you awake at night and get them answered, so you can really obtain the ultimate learning experience that you seek.
5. Have fun! To celebrate our 5th Birthday we are treating you to a surprise golfing and drinks night where all are welcome to try win the ultimate team building exercise or simply have a glass or two with the most influential people in the industry
Michael Donald
Chief Commercial Officer & Customer Experience Executive Bank of America
Alastair Barter
Senior Policy Officer (Business and Industry), Strategic Liaison Information Commissioner's Office (ICO)
Adrian Garcia-Sierra
Head of Digital & Experience AXA Wealth
Stephen Ingledew
Managing Director Customers and Marketing Standard Life
Michael Gazala
Vice President & Research Director Forrester Research
Manuela Pifani
Head of Customer Strategy & Experience, Direct Line Group
View all speakers
Here are some quick links for more information about the event and how to get involved.
Learn more about what's happening at the event for YOU.
Check out our BEST RATES for you and your team!
Confirm your place today - BOOK NOW!
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Questions? Contact us on 0800 652 2363 or +44 (0) 20 7368 9300 or email email@example.com now!


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Jackie Bradley's college coach marvels at debut - 0 Comments
NEW YORK — Ray Tanner wanted to be here, sitting in the second deck at Yankee Stadium with Jackie Bradley Jr.'s entourage. But with a pair of inescapable meetings binding him to his office, the University of South Carolina athletic director resorted to the next best thing.
"We brought a TV in," Tanner said by phone yesterday, "and I told the people that came in, 'You're going to have to multitask because I have to watch this game.' "


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7 results for "Lowes Milton"
Antigua and BarbudaOct 1995by Susan Lowes and Riva Berleant-Schiller
- Only 1 left in stock - order soon.More buying choicesEligible for FREE Super Saver Shipping.Starring:Clara Kimball Young, Gareth Hughes, et al.Directed by :Albert Parker, Harry Garson, et al.
Crimson Romance1934by Ben Lyon and Sari MaritzaCurrently unavailableStarring:Ben Lyon, Sari Maritza, et al.Directed by :Runtime :1 hr 11 mins
Playmakers: Amazing Origins of Timeless ToysFeb 2004by Tim WalshExcerpt
... Lowe, Milton Bradley Yahtzee's original 1956 packaging featured ...Read more
Official Major League Baseball Fact BookFeb 11 2002by Sporting NewsExcerpt
... 14-7 4-26 Min. W 2-0 8 2 Nomo Milton Lowe 15-7 4-27 K.C. W 9-2 12 7 ...Read more


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NASA has awarded Boeing (NYSE: BA) a task order to provide crew rotation services for a planned 2017 mission to the International Space Station under the company's potential $4.2 billion Commercial Crew Transportation Capability contract. The agency said Thursday that Boeing has completed an integrated critical design review of its ...Read More »
John Shannon Appointed Boeing Space Launch System VP, Program Manager
John Shannon, formerly Boeing's (NYSE: BA) International Space Station program manager, has been named vice president and program manager for the company's space launch system. He succeeds retiring Virginia Barnes, Boeing said Thursday. Shannon previously served as deputy associate administrator for NASA's exploration planning in the human exploration and operations ...Read More »
NASA Issues 9-Month Extension for Wyle's Johnson Space Center Support Contract
Wyle's integrated science and engineering group has received a nine-month, $97 million contract modification from NASA that extends the company's support for the Johnson Space Center's Human Health and Performance Directorate. NASA said Tuesday the modification brings the contract's total value to $1.5 billion and extends Wyle's services through the end of January 2016. The ...Read More »
SpaceX, Orbital ATK to Transport Supply Cargo to ISS; Stephanie Schierholz Comments
Space Exploration Technologies and Orbital ATK (NYSE: OA) have received contract modifications with undisclosed amounts from NASA to carry supplies to the International Space Station, Spaceflight Now reported Saturday. Stephen Clark writes SpaceX's Dragon spacecraft and Orbital ATK's Cygnus supply ship will each transport 44,000 pounds of provisions, food, clothes, ...Read More »
Craig Cooning Selected to Wash100 List for Leadership with Boeing Space Systems
Executive Mosaic, Tysons Corner, VA March 10, 2015 – Craig Cooning, president of the network and space systems division at Boeing, has been elected into this year's Wash100 list of the most influential leaders in GovCon for his role in the group's contract wins in the past year. The Wash100 is the ...Read More »
Ward Johnson: Jacobs to Continue NASA Engineering, Science Services Work
Jacobs Engineering Group (NYSE: JEC) has received a $120 million contract modification to continue its work on a NASA engineering and science services program at the Marshall Space Flight Center in Huntsville, Alabama. The company will provide science, engineering and technical support for the Space Launch System, International Space Station, James Webb Space Telescope and other space ...Read More »
Boeing, SpaceX Win NASA Commercial Space Transportation Contracts
Boeing (NYSE: BA) and Elon Musk's startup firm SpaceX have both won contracts to transport U.S. astronauts to and from the International Space Station for NASA. Charles Bolden, NASA administrator, said in a press conference Tuesday from Kennedy Space Center that the contracts are worth up to $6.8 billion combined, with up to $4.2 billion ...Read More »
Report: NASA to Award Space Transportation Contract by Early September
NASA will award a contract or contracts to develop space vehicles for transporting U.S. astronauts to the International Space Station by the end of August or in early September, National Journal reported Tuesday. Marina Koren reports that the future commercial spacecraft would end U.S. dependence on Russia's Soyuz capsules to transport each astronaut for ...Read More »
NASA Triggers $178M Option on Jacobs' Kennedy Space Center Operations Contract
NASA has awarded a two-year, $178 million contract option to Jacobs Technology to continue management and implementation services for technology and operations at the agency's Kennedy Space Center in Florida. The agency said Monday that it also exercised a two-year extension for the contract's indefinite-delivery indefinite-quantity ordering provision, which is worth up to ...Read More »
SAIC Wins Potential $1.7B NASA Spaceflight Support IDIQ
Science Applications International Corp. (NYSE: SAI) has won a potential 10-year, $1.76 billion contract to provide biomedical, medical and health services for human spaceflight programs at NASA's Johnson Space Center in Houston. The indefinite-delivery/indefinite-quantity contract contains cost-plus-award-fee task orders for work over five base years and two option periods, NASA said Thursday. SAIC ...Read More »