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Box Office Report: 'Life of Pi' a Hit in Asia, Crosses $80 Million Internationally
Ang Lee's 3D event pic has now earned $132.7 million worldwide -- including $53 million in China.
Twentieth Century Fox's 3D adventure Life of Pi -- resonating strongly with Asian audiences -- has jumped the $80 million mark at the international box office, fueled by strong business in China, Taiwan, India and Hong Kong.
Directed by Ang Lee, born in Taiwan, Life of Pi is heading into its third weekend of play in North America and select foreign markets. Its domestic total is north of $52 million for a worldwide cume of $132.7 million. In China, ticket sales have reached $53 million.
COVER STORY: THR's Director Roundtable: 6 Auteurs on Tantrums and Quitting While They're Ahead
Life of Pi is based on Yann Martel's best-selling 2001 novel about an Indian boy lost at sea with a Bengal tiger named Richard Parker. Boosted by the movie, the book is expected to unseat Fifty Shades of Grey for the No. 1 spot on The New York Times bestseller list this weekend.
In the film, Pi is played by young Indian actor Suraj Sharma.
Life of Pi's Indian cume is $7.3 million, a strong number for an American title. Life of Pi has grossed north of $6 million in Taiwan and north of $4 million in Hong Kong.
PHOTOS: THR's Director Roundtable: Ben Affleck, Quentin Tarantino, Ang Lee and More
The big question is how the film will fare as it continues to roll out internationally. Costing $120 million to make and millions more to market, Life of Pi will need to do substantial business worldwide if Fox is to recoup its costs. The studio is hoping that awards buzz for the movie will help increase audience interest and prolong its theatrical run.
Life of Pi still has dozens of foreign markets in which to open. It debuted in Spain last weekend, grossing $2.4 million to come in No. 1.
Never miss a story. Stay up-to-date with THR's Daily Headlines.
Must Reads
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CBS Entertainment Chief and "Loudmouthed Feminist" Nina Tassler Reveals the Strategy Behind 'Supergirl' Gamble
Paul Rudd and Marvel's Kevin Feige Reveal 'Ant-Man's' Saga, from Director Shuffle to Screenplay Surgery to Studio's "Phase Three" Plans
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nsj123's review of Maybelline Color Sensational - Totally Toffee
74 reviews
74% would repurchase
Package Quality: 3.9
Price: $$
Package Quality: 3.9
Price: $$
on 1/1/2013 9:46:00 AM
Age: 19-24
Skin: Very Oily, Fair-Medium, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
I have been on the lookout for a nude lipstick for my skin tone. mac's Creme de nude, shy girl, revlon's soft nude, rimmel's undressed, all look so strange.
This is one of my favourite lipsticks now. Its so flattering. Id recommend it to all medium skin toned girls.
Im goin to get a backup of this <3
Read all 74 reviews of Color Sensational - Totally Toffee
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subset: commoncrawl


text:
The level 36 ledge boss seems to have abused it too despite the damage was all cold.
It's a stupid twitch chat meme.
Posted by FillInTheBlank
on October 21, 2013 12:33 AM
Twitch chat emote.
ign: tatefin
It was pretty freaking broken, found out about it earlier and just ran some tests. Lol, was 2-3shotting piety with bear trap on merc
IGN: aMonsterTruck
Because I'm Based.
I wonder if it would have taken you any longer to actually explain the bug rather than say of where to find it. :/
Also answer to you @Kiffen - http://www.pathofexile.com/forum/view-thread/543409
100-200x as much, from what op of that thread says.
Last edited by DestroTheGod on October 21, 2013 12:39 AM
Posted by DestroTheGod
on October 21, 2013 12:35 AM
Seeing as how Cold to Fire will be getting a boost with AoF coming back... good fix
i too fas fo youuuuuuu
Like the others mentioned, it's a Twitch chat emote. Shortform for sarcasm.
PocketMonsters, ElectronicArts, CommandAndConquer, CaptainFairgraves, AgentTanya, OcarinaOfTime
I hope you don't mind posting this here, Chris, since it's only 15 mins til patch.
Here's an example of how horribly, horribly broken Cold to Fire was;
(Sorry about the loud music)
It was fun for the 2-3 days we played around with it, but I'm glad to see it's getting patched. It was pretty game-breaking haha.
IGN: CorpsejackMenace
Last edited by Munsie on October 21, 2013 12:39 AM
I must again point out, that 30 mins is no longer enough of a warning.
Not with Poorjoy's in game now, which is a fkn awesome map to solo as a challenge while not decked out in bought BiS gear.
I've been in that map for over an hour and a half before on low dps tanky character, even doing it on a high dps character, I was still in there for over the 30 mins warning.
If we had them drop while players were running regular maps then they'd merely stockpile them and occasionally get some free Atziri runs ~ +2 maps are a dangerous thing. They can cause players to get out of their depth ~ We have a few big improvements coming for leech. We think you'll like them.
Posted by TheAnuhart
on October 21, 2013 12:39 AM
"Kappa" is for trolling/fishing Kappa.
Posted by nheowitzki
on October 21, 2013 12:40 AM


text:
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Amazon-Wunschzettel von Ellen van Dyke
(Bücher, DVDs, weitere Produkte)
LinkedIn: Ellen Van Dyke | LinkedIn
largest business network, helping professionals like Ellen Van Dyke discover ...
Management & Beteiligungen
CHRISTINE NATALIE ELLEN DYKE (director) :: OpenCorporates
Information on CHRISTINE NATALIE ELLEN DYKE (director)
Telefonnummern, Adressen & Branchenkontakte
Ellen F. Dyke Lawyer Profile - martindale.com
Washington, District of Columbia - Ellen F. Dyke profile by Martindale-Hubbell. Find Ellen F. Dyke experience and credentials on martindale.com.
Ellen Van Dyke | Green Valley Alliance | ZoomInfo.com
View Ellen Van Dyke's business profile as Activist at Green Valley Alliance and see work history, affiliations and more.
Private Homepages
Ageism | Author Ellen Frances Dyke
Posts about Ageism written by ellenfrancesdyke
Write to Ellen Dyke - Publi-contact United-Kingdom
Write an open letter to Ellen Dyke
County Affiliates | Indiana Right To Life
Allen County Right to Life Fort Wayne, IN Director Cathie Humbarger 260-471-1849 firstname.lastname@example.com County Right to Life
(1 - 4 von 15
Feature Teacher: Ellen Van Dyke
Ellen Van Dyke of Manton School was recognized in April with the Feature Teacher award by Larry Champion, Tehama County Superintendent of Schools and Tyler...
Announcements - Green Valley Road Alliance
Ellen Van Dyke for GVA. Message shared from Rural Communities United 5/22: We just received word from County Elections. It's official!... Rural Communities ...
Schwäbische Zeitung das Onlineportal
Die Tageszeitung für die Region von Aalen bis zum Bodensee, von Ulm bis zum Schwarzwald.
Convention Center
Nijinski and Toben were awarded the "Scot To Do" Challenge Trophy, donated by Ellen Van Dyke, for their division championship and the ...
Schlechte Nachrichten
(1 - 4 von 11
CWGC - Casualty Details
Commonwealth War Graves Commission
findagrave: Sarah Ellen Van Dyke Lingenfelter (1852 - 1940) - Find A Grave...
Birth: 1852. Death: 1940. Mother of. Mrs Agnes Wight Mrs Nellie Reddick Mrs. Griggs Mrs Belle Wilkinson Mrs Mary Lingenfelter snd. William R ...
Barbara Van Dyke Obituary - Coutts Funeral Home & Cremation Centre |...
Obituary for Barbara Van Dyke, Van Dyke Barbara Ellen passed away peacefully at Cambridge Memorial Hospital on Tuesday December 15, 2009 in her 72nd year....
Ellen Van Dyke Obituary - Denver, CO | Denver Post
VAN DYKE, ELLEN GAIL Homemaker, 64 Ellen Gail Van Dyke of Broomfield. Wife of Pat; mother of Donna Rillings, Mike Van Dyke, and Leann Boatright; grandmother...
(1 - 4 von 17
Mary Ellen Van Dyke (1856 - 1925) - Genealogy - Geni
Genealogy for Mary Ellen Van Dyke (1856 - 1925) on Geni with over 100 million profiles of ancestors and living relatives. Page updated ...
Ellen Dyke - Genealogy - Geni
View Ellen Dyke's genealogy family tree on Geni, with over 140 million profiles of ancestors and living relatives.
John BULFIN & Isabel MOORE - Lawrence, Otago :: FamilyTreeCircles.com...
William Archibald Bulfin - married Ellen DYKE in 1905 - two of their known children were: 1906 - Isabel Florence Bulfin 1907 - Frances Lilian Bulfin
Jane Ellen Dyke 1853 - Wincanton
Profile of Jane Dyke, born December 17, 1853, including biography and genealogy.
(1 - 4 von 6
[ [ [ Adam and Steve [ ADAM AND STEVE ] By Dyke, Ellen Frances ( Author )Aug-28-2012 Hardcover
von Ellen Frances Dyke, iUniverse.com, 2012, Gebundene Ausgabe
[ [ [ Adam and Steve [ ADAM AND STEVE ] By Dyke, Ellen Frances ( Author )Aug-28-2012 Paperback
von Ellen Frances Dyke, iUniverse.com, 2012, Taschenbuch
Officers and Enlisted Men of the United States Navy Who Lost Their...
Cause: Pneumonia, lobar. Next of kin : Mother, Mary Ellen Dyke, R. F. D. No. 1, Livermore Falls, Me. Eades, Lawrence Harvey, water tender, United States Navy.
The Plantagenet Roll of the Blood Royal: The Mortimer-Percy Volume -...
The present volume treats the descendants of Lady Elizabeth Mortimer, wife first of Henry, Lord Percy, K.G., called
Dokumente zum Namen
Dyke, Ellen [WorldCat Identities]
Most widely held works by Ellen Dyke. Student composition symposium ( Recording ) 1 edition published in 1985 in English and held by 1 WorldCat member ...
Hugh Backstondeine (Baxendell) Descendants - HB104.htm
BACKSTENDEANE was christened 12 Jan 1660 in Shevington, Standish, Lancashire ... Josiah was not married (1) to Ellen DYKE.
... University of Connecticut School of Law, Knight Hall, Room 202, 35 Elizabeth St., Hartford, CT 06105 GEORGE H. BUXTON, 31 E. Tennessee Ave., Oak Ridge, TN 37830 ELLEN DYKE
Feet of Fines: CP 25/1/83/57
James Verne, Richard Kerver, William Dyke, Ellen Dyke: Places: Much Marcle, Preston, Yatton CP 25/1/83/57, number 12. County: Herefordshire. Place:
Veröffentlichungen allgemein
A Guest Post – Rural Communities United | Coalition For Change
Spread the word to get on the RCU email list for updates! Ellen Van Dyke for Rural Communities United. www.RuralCommunitiesUnited.com.
Artikel & Meinungen
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pinterest.com: ELLEN DYKE on Pinterest
See what ELLEN DYKE (kasey351) has discovered on Pinterest, the world's biggest collection of everybody's favorite things.
Ellen Van Dyke Tripp - Genealogy.com
Tripp: Looking for parents of Ellen Van Dyke, 1804-1869, ... Read more on Genealogy.com!
UPDATE: Former VP candidate Palin coming to Evansville
The event in The Centre's Bill Brooks Exhibition Hall has sold out of about 2,050 dinner tickets, but Right to Life Executive Director Mary Ellen Van Dyke said
Jane Ellen Dyke - Genealogy RootsChat.Com
Hi, Anyone know of a Jane Ellen Dyke of Salford? Thanks.
(1 - 20 von 56
portbyronhighschooljuniorprom - pbahof
Mary Randolph, Shirley Mapley, Barbara Miller, Ellen Van Dyke, Richard Ames, Alan Prosser, Ronald Thurston, William Wenzel. 1948 Theresa Bratek James ...
Foley, Ellen-Van Dyke Equities LLC - Yahoo Local
Find Foley, Ellen-Van Dyke Equities LLC in Sterling Heights with Address, Phone number from Yahoo US Local. Includes Foley, Ellen-Van Dyke Equities LLC ...
Sister David Ellen Van Dyke
Sister David Ellen Van Dyke. "And now I am no longer in the world, but they are in the world, and I am coming to you." (John 15:19b). "In a small ...
ELLEN DYKE (1888-1976) | Social Security Death Index | Free Ancestry...
Ellen Dyke was born in 1888 and passed away in 1976 . Access the Free Ancestry Search on Mocavo and find your ancestors for free!
Ellen Dyke : Death : Liverpool Echo
Ellen Dyke : Death. Published in the Liverpool Echo on 15th March 2010 (Distributed in Liverpool). This notice has had 11 visitors. DYKE - ELLEN. March 9 ...
Ellen Dyke Attorney Reviews & Ratings - LawyerRatingz.com
Ellen Dyke reviews. Add a picture of this attorney Save this listing Search again. Map & Info. Ellen Dyke Attorney. Vienna, VA. Practice Area: General Practice
Brand`s Ahnen - Personenangaben 1381
Nathan Trenner heiratet Mary Ellen Van Dyke. Er ist geboren am 21 Juli 1842. Er stirbt an am 21 April 1870 im Alter von 27.
Ellen Dyke, Holmsjö - telefonnummer, mobilnummer, adress ...
Ellen Dyke Holmsjö - telefonnummer, mobilnummer, adress, karta & vägbeskrivning.
Mary Ellen Dyke, 709-677-2308 | 7096772308, Eastport, A0G1Z0 Postal...
View the profile of Mary Ellen Dyke, resident of , Eastport A0G1Z0. You can connect with Mary Ellen Dyke at 709-677-2308
Ellen Dyke Obituary - Phillips Funeral Home
Ellen M. Van Dyke, age 100 of Barnett died Monday, May 26, 2008 in Barnett, Missouri. She was born on October 10, 1907 in the state of Iowa to the late Richard ...
Ellen Dyke - I1297 - Individual Information - - PhpGedView
LUCY ELLEN DYKE director information. Free director information.
LUCY ELLEN DYKE - a free Director Summary including all company appointments. Instant Director Report for Risk Scores, County Court Judgements, Mortgages and...
Ellen Van Dyke | Transparent California
Search California public employee salaries and pensions
Eliza Ellen Van Dyke - Our Family Tree
Eliza Ellen Van Dyke, b.8/18/1851, IL, dau of Ferdinand Van Dyke + Orryanna Chase
Inscription for Elizabeth Ellen Dyke
Inscription for Elizabeth Ellen, Dyke at Box Hill
View Record - 1910 King County (Federal) - Ellen E Dyke - Washington...
Washington State Digital Archives the is first in the nation Digital Archives to Preserve the electronic Records of both State and Local Government.
2012 Clinton Building Marker Recipients | Historical Society of...
Marilyn married Henry Louwerens and they retained ownership until the house was sold to David Pray in 1976. In 1978 the property was sold to Ellen Van Dyke.
3540 Ambassador Rd, Village Of Wellington Homes, Palm Beach County,...
Property details for 3540 Ambassador Rd, Village Of Wellington, FL 33414 including photos, sales history, comparable sales, schools, sq.ft, bedrooms, and more.
Around The World - Kate Cullen
Braveheart Cycling Fund
Browse Encyclopedia | Dickinson College
James J. Patterson was born in Philadelphia on June 22, 1838, the son of John and Ellen Van Dyke Patterson. He grew up in rural Juniata County near ...
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text: Man Pleads Guilty To Sending U.S. Space Info To China Elaine Chow and 66 othersEditDelete Invite manuallyPromoteXDismissXUndismissBlock for gizmodoHide In what's bound to be embarrassing for the Chinese space program, the president of high-tech company AMAC International has pleaded guilty to giving China military data about fueling systems for space launch vehicles. Shu Quan-Sheng is a Chinese native who's a naturalized U.S. citizen. The incident puts a black smear… » 11/18/08 2:00am 11/18/08 2:00am


text:
Sometimes, it feels as if we are eavesdropping on day-to-day conversations rather than just hearing the usual litany of platitudes and regrets.
Sometimes, it feels as if we are eavesdropping on day-to-day conversations rather than just hearing the usual litany of platitudes and regrets.
"Stray Dog" largely succeeds because Granik's technique complements her subject. Both he and the film are modest in their goals and cherish the value of…
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
Nick Allen picks one of his favorite Roger reviews.
An excerpt of Tony Fitzpatrick's column, "Dime Stories," which has its first published compilation in stores this month.
Nick Allen picks one of his favorite Roger reviews.
An excerpt of Tony Fitzpatrick's column, "Dime Stories," which has its first published compilation in stores this month.
A review of Han Gong-ju from a Far Flung Correspondent.
An FFC responds to Kyle Smith's assertion that women can't enjoy GoodFellas.
America takes on Trump; "St. Elmo's Fire" turns 30; Music in Sofia Coppola's films; Chat with "Vampire Diaries" DP Darren Ganet; R.I.P. Brian Clark.
The table of contents for RogerEbert.com's complete coverage of AFI Docs 2015.
* This filmography is not intended to be a comprehensive list of this artist's work. Instead it reflects the films this person has been involved with that have been reviewed on this site.
What should be nominated for Emmys this year? Let us guide the way.
A review of Showtime's Happyish with Steve Coogan, Kathryn Hahn, and Bradley Whitford.
Marie writes: Last week, in response to a club member comment re: whatever happened to Ebert Club merchandize (turned out to be too costly to set up) I had promised to share a free toy instead - an amusement, really, offered to MailChimp clients; the mail service used to send out notices. Allow me to introduce you to their mascot...
Marie writes: It's official. I have died and gone to heaven. For here below, as part of an ongoing series exploring Britain's architectural wonders, the Observer's architecture critic Rowan Moore, introduces a spectacular interactive 360-degree panoramic photograph of "The grand staircase in the St Pancras Renaissance hotel" - which I regard as one of the most beautiful pieces of architecture I have ever seen. I adore this building and always will; it's the stuff of dreams. (Click photo to enlarge.)
Go here to explore a 360 panoramic view of the grand staircase!
Marie writes: Belgium club member Koen Van Loocke has submitted the following and it's so awesome, I have no words. But first, background..The Cinematic Orchestra is led by composer/programmer/multi-instrumentalist Jason Swinscoe, who formed his first group "Crabladder" in 1990 while a Fine Arts student at Cardiff College. The group's fusion of jazz and hardcore punk elements with experimental rhythms, inspired Swinscoe to further explore the musical possibilites and by the time the group disbanded in the mid-'90s, he was playing DJ at various clubs and pirate radio stations in and around London.


text:
Browsing Tags Yoochun
[TRANS] 130729 More Excerpts from "The JYJ" Magazine Vol. 2: Yuchun's Interview
Music & Acting:
"Even if I release a solo album, I want to include one or two pieces of music or songs and essays etc; I want to present it in a slightly special way."
Park Yuchun mentioned in passing that his works gave him the opportunity to meet colleagues who are like friends. With Han Ji Min from 'Rooftop Prince' and Oh Jung Se from 'Missing You', they talk like there is no need to rest to take a breath. Seems like these 2 persons are a special existence for Yuchun.
(Source: @02springtree via 暖日呀呀 Trans: Christie)
Epitone Project's 'Let's Go':
The song Yuchun listens to when feeling sad: Epitone Project's 'Let's Go'.
"Let's go! Let's go for a walk, walk towards those distant days somewhere, when we once laughed.
When I'm sad or depressed, I will listen to Epitone Project's 'Let's Go'. I like Epitone Project's style of music. Although it is about love, it makes you think of the time when you were young and had no worries, and so I like it."
(Source: @mm_wide via 暖日呀呀 Trans: Christie)
Read More →
[VIDEO] 130729 Yoochun mentioned in Mnet's Beatles Code 2
[HQ SCANS] JYJ featured in K-BOY Paradise Vol. 8
Note: This magazine issue was released at the end of February 2013
[TRANS] 130726 PD Kim Won Suk mentions Yuchun in an interview
"I like cute faces that has yet a tough charm. Rather than guys with thick lines, (I prefer) the ones who look pretty yet tough at the same time. (Interviewer: Park Yuchun?) Yes. (Someone) like Park Yuchun. As I've always said, the only member of TVXQ I wanted to cast (in a drama) was Park Yuchun."
(T/N Kim Won Suk PD is SKKS PD.)
[PIC+INFO] 130726 Yuchun on the Cover of "It's KOREAL" (Sept. Issue) Japanese Magazine
Released today!
Yuchun will be mentioned in the article titled "Summer's Fascination for Beautiful Men",
along with Song Seung Hun, Jo In Sung, Joo Ji Hoon, and more!
Credit: Amazon.co.jp
Shared by: JYJ3
[PICS + INFO] 130725 Moldir Korea's Showroom, Coffee Cojjee and Bum's Story Updates
As you know, Kim Jaejoong's MOLDIR have become a brand endorsed by many korean stars such as: JYJ's Yoochun and Junsu, Song Jihyo, Gyuri Nam, Daniel Choi, Baek Jiyoung, Lee Jihye, Simon D, DO, Jang GeunSuk, B2ST's Yoon Dujun – Yang Yoseob – Lee Gigwang, BAP's Bang YongGuk – YoungJae – Daehyung and Zelo, Seo IngGuk, Sista's Bora, After School's Nana. Athletes like: Ryu Hyun-jin, Yoon SukMin, and many more. Please take a look of the full list of celebrities endorsing Moldir here
The smartphone case of Moldir brand designed by Jaejoong was sold out when it was released in Japan (news).
Recently MOLDIR has opened a Showroom, you can find more information of the location here
[TRANS] High Cut: Romantic and sexy, 5 best kissers in TV dramas – Park Yuchun
Unusually dynamic lips
Park Yuchun
Lips assessment:
Pouty, thick and sexy lips.
With a cherry-colour that makes even cosmetic models want to run away crying.
Sure-kill technique:
Before actual kiss, use lips to just make contact, very carefully, like welcoming and yet rejecting.
And highlight long eyelashes by closing eyes.
Compared with other actors, the liveliness of his lips in kissing scenes is unrivaled.
Looking at the very realistic kissing scenes in 'Rooftop Prince' and 'Missing You', after the lips touch, he romantically takes in his partner's lips and their lips become one in a rhythmic movement. The upper lip is better at attacking than the lower lip. From the simple bird kiss ("bobo") to the deep kiss, they are perfect. The sadness in his eyes and expression make hearts pound even more. It is a magical skill that even fans who dislike watching him in close physical contact with another woman will continue to watch. He is an actor that is most able to create a kiss of sweetness and bliss.
Source: DC PYC Gall
Kor-Chin trans by: 暖日呀呀
Chin-Eng trans by: Christie
Shared by: JYJ3


text:
Roy Nelson isn't exactly the most 'athletic' heavyweight in the UFC, but he's made up for it with skill, a hard head, and an overall toughness. Recently Nelson was asked if he would consider using testosterone replacement therapy and here is his vague answer:
Related MMA gear from the UG Store
tags: Roy Nelson (detail)
Recent Comments »
2/11/14 1:28 AM by Throwin'Knuckles
I love Roy but, he needs to consider a salad
2/11/14 1:22 AM by MySonTommyGunn
C'mon it's Hoy Nelson, give him something.
2/10/14 11:06 PM by RearNakedJoke
Turkey Reuben Taco?
2/10/14 11:05 PM by huggy bear
This. in the other major sports TRT exemptions are extremely rare but in the UFC alone there is like 20 guys on it. It's a fucking joke I guarantee at least 75% of guys in mma are using some kind of ped.
2/10/14 10:31 PM by knee smash
Lol how do u get offered TRT? More proof this shit is a scam, make steroids legal already
2/10/14 9:15 PM by Doem
So drs are basically selling it. That's nice


text:
Recent Stories
- Pupils get a taste of science and technology
- Student's solar panel project shines at industry awards
- Lancaster's work to support business and the economy recognised by prestigious award
- Lancaster University launches unique postgraduate agricultural course with support from Waitrose
- Moving to the next generation in wireless technology
- Partnership with EDF Energy to boost student job prospects
- MSc International Innovation gives students chance to work with UK and Chinese businesses
- New Engineering Building wins prestigious architectural awards
- Strong representation in Complete University Guide 2016
- Lancaster University challenges aspiring engineers
Students Demonstrate PremiershipLive.com
Students on ICT Focus' Certficate in Systems and Network Programming (CSNP) successfully demonstrated their group project at InfoLab21 on Wednesday 25th April.
They presented a distributed application that serves as a portal for football fans to view online content such as videos, fixtures and news, and share and search information including fan-provided content.
Course Tutor Dr. Paul Smith said, "Before starting the certificate many of the students had undertaken little or no programming, and the success of the demonstration highlights their hard work and effort".
The four students have not only successfully completed CSNP but are also the first students to complete the University's Foundation Degree in Network & Systems Engineering.
The demo is the result of a two month part-time project, where the students only met in person three times.
Head of ICT Focus, Rachel Fligelstone said, " The dedication and commitment that the students have given to their studies has been outstanding. Their project was carried out alongside work and family commitments and can't have been easy - all four should be extremely proud of what they have achieved"
Wed 09 May 2007
Latest News
Pupils get a taste of science and technology
Over 200 pupils from eight schools across the North West got a taste of what it's like to study STEM subjects at Lancaster University.
Wed 01 July 2015
Student's solar panel project shines at industry awards
An engineering student has received an award in the Institution of Mechanical Engineers Mechatronic Student of the Year contest.
Wed 10 June 2015
Lancaster's work to support business and the economy recognised by prestigious award
Lancaster University's work to support businesses and the economy has been recognised by the inaugural Educate North Awards.
Fri 05 June 2015
Lancaster University launches unique postgraduate agricultural course with support from Waitrose
Lancaster University, with support from leading retailer Waitrose, is launching a new on-line postgraduate course designed to enable food-chain professionals to meet the challenges of future food production.
Tue 02 June 2015


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A year ago, few would've predicted that Jonah Hill would go from being a graduate of Judd Apatow's raunch-com school (Superbad, Get Him to the Greek) to landing an Oscar nomination for Moneyball, co-writing and starring in a successful reboot of the 21 Jump Street franchise – and securing roles in future weighty dramas like True Story and Martin Scorsese's The Wolf of Wall Street.
Hill is poised to extend his win streak even further, now that he's set to appear in Quentin Tarantino's Django Unchained. The actor previously passed on the project, because of his busy schedule, but due to either an unexpected opening in his work slate, or (more likely) a reduced role, Hill's now accepted the offer.
Although Hill's role in Django Unchained has yet to be (officially) revealed, inside word is that he will not be taking on the part of Scotty Harmony – the gambler who loses Django's (Jamie Foxx) enslaved wife, Broomhilda (Kerry Washington), to the debonair but utterly despicable plantation/brothel owner Calvin Candie (Leonardo DiCaprio). Some of you readers out there may recall that's the "glorified cameo" which was left up for grabs by Sacha Baron Cohen.
The Django Unchained cast includes all the aforementioned stars, alongside TV icons like Don Johnson (Miami Vice) and Gerald McRaney (Major Dad) – plus, Tarantino favorites Samuel L. Jackson and Christoph Waltz – with minor characters being brought to life by such folk as musician-turned actor/filmmaker RZA and Justified alum Walton Goggins and M.C. Gainey. Suffice it to say: this movie reads as a pretty crazy affair, even before you take the controversial storyline into consideration.
Django Unchained storms into U.S. theaters on December 25th, 2012.
Source: Deadline


text:
Bell Top Dog Again at Skipton 2015-Feb-18
North Yorkshire's John Bell rung up yet another top price success at Skipton's
opening 2015 working sheep dogs sale with an outstanding young black and white
bitch that sold for 4,500gns.
Rules as Shaun Richards Crowned Top Dog 2014-Oct-29
Shaun Richards was top dog again at Skipton Auction Mart's
autumn sale of working sheep dogs when selling his three-year-old
bitch Queen for 4,050gns.
Clocks 4,000gns Top Price at Sheepdog Sale 2014-Jul-23
A three-year-old Border Collie bitch named Tock ticked all
the right boxes to clock up the day's top price of 4,000 guineas at Skipton Auction Mart's
annual summer sale of working sheep dogs.
Averages for Bala Sheep Dogs 2014-May-27
The Spring Sale of working sheepdogs at The Rhiwlas Estate, Bala proved to be
a very successful day with a large crowd of potential buyers witnessing record
averages for the dogs forward.
Mart's Spring Sale of Working Sheep Dogs 2014-May-21
Northern Ireland's Hugh McKee led the field on price at Skipton Auction
Mart's annual Spring sale of working sheep dogs.


text:
My site is finally live, go check it out here
This is just a little side project to learn some code and is still a work in progress so give me a shout with any improvements, of if you notice any issues.
Big thanks to @Balraj Chana for the awesome psd.
More Chris Bannister
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The bench from 'The Fault in Our Stars' has gone missing in Amsterdam
Sometimes, a movie can have so much significance to your life that you simply have to buy some kind of memento. A T-shirt. A poster. Maybe you'll even hit up eBay for some unique memorabilia.
In the case of The Fault in Our Stars (TFIOS), it seems that a fan may have gotten so attached to a piece of furniture from the movie that they actually stole it.
In TFIOS, an iconic scene shows lovestruck teens Hazel and Gus kissing and talking on a bench in Amsterdam. Some time in the past couple of weeks, that particular bench (which was previously attached to the ground) has gone missing.
"It's a bit embarrassing, because we do keep good track of them, but it's gone all right," said Amsterdam city spokesman Stephan van der Hoek.
Amsterdam city representatives didn't notice that the bench had vanished until TFIOS fan tourists began asking where it had gone, as the empty space had been disguised by a large potted plant. In recent months, Amsterdam tourist locations have noticed an uptick in TFIOS-related visitors, but this is the first time anyone has reported a potential theft.
Of course, the bench could have gone missing for some other reason, but it's difficult to imagine why else someone might decide to steal a heavy old park bench with a street value of pretty much nil. This kind of heist actually sounds like the plot of a John Green novel in itself, if he ever decided to branch out into crime fiction.
Apparently the bench will be replaced in the next couple of weeks, but any TFIOS fan would be able to tell you that the replacement can't possibly be the same.
H/T BBC Newsbeat | Screenshot via thefaultinourstarsmovie
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The US Centers for Disease Control and Prevention (CDC) recently revised their HIV screening guidelines to promote testing and earlier entry to care. Prior analyses have examined the policy's cost-effectiveness but have not evaluated its impact on government budgets.
We used a simulation model of HIV screening, disease, and treatment to determine the budget impact of expanded HIV screening to US government discretionary, entitlement, and testing programs. We estimated total and incremental testing and treatment costs over a five-year time horizon under current and expanded screening scenarios. We used CDC estimates of HIV prevalence and annual incidence, and considered variations in screening frequency, test return rates, linkage to care, test characteristics, and eligibility for government screening and treatment programs.
Under current practice, 177,000 new HIV cases will be identified over five years. Expanded screening will identify an additional 46,000 cases at an incremental five-year cost of $2.7 billion. The financial burden of expanded HIV screening will fall disproportionately on discretionary programs that fund care for newly identified patients and will not be offset by entitlement program savings. Testing will represent a small proportion (18%) of the total budget increase. Costs are sensitive to the frequency of screening and the proportion linked to care.
The expanded HIV screening program will have a large downstream impact on government programs that fund HIV care. Expanded HIV screening will not meet early treatment goals unless government programs have sufficient budgets to expand testing and provide care for newly-identified cases.
In September 2006, the US Centers for Disease Control and Prevention (CDC) revised their HIV screening guidelines to increase rates of detection and facilitate early entry into care. Benefits of earlier detection and entry into care include better outcomes for patients themselves and lowered rates of HIV transmission to others due to biological (decreased infectivity as a result of treatment) and behavioral (reductions in risk behavior due to knowledge and counseling) mechanisms (1-4). The revised CDC guidelines encourage routine testing in all healthcare settings for the general population and annual testing for high-risk populations (5). However, financing concerns are a major barrier to implementing the recommendations (6). If government testing and care programs are under-funded, expanded screening may result in large numbers of newly-identified cases who are unable to receive care.
The CDC considered cost-effectiveness evaluations of expanded screening policies in its recent decision (7). Previous analyses have indicated that expanded HIV screening is cost-effective in many settings (8-10) and alternative targeted screening strategies have also been advocated on efficiency grounds (11). However, efficient policies may not be affordable from a payer's perspective if the stream of financial costs is larger than budget allocations (12). The budget requirements for government programs to provide HIV testing and appropriate medical care to the entire eligible US population are unknown (11). It is unclear how expanded screening in the US may differentially affect discretionary government programs funded by fixed annual appropriations versus entitlement programs with budgets that automatically expand as demand increases. This question is particularly timely given the requirement for reauthorization legislation in the US Congress for the Ryan White HIV/AIDS Program (RW) before December 2009, and national debates on health care reform.
We conducted a budget impact analysis of expanded HIV screening using a published simulation model of HIV screening, disease, and treatment and national data on HIV epidemiology, enrollment in public healthcare programs, and program eligibility. We forecasted the impact on government budgets for testing programs, discretionary treatment programs (such as RW), and entitlement programs (Medicaid and Medicare) under current practice and expanded screening scenarios over a five-year period. We excluded patients covered by the Veterans Administration (VA) because the VA has a distinct single-payer system. We also excluded patients with private insurance in order to focus on government budgets.
The predominant sources of government funding for HIV care in the US are the federal-funded Medicare and federal- and state-funded Medicaid entitlement programs, and the discretionary Ryan White HIV/AIDS Program (13-16). Although specific eligibility criteria vary across states, HIV-infected individuals generally qualify for Medicaid after they meet low-income and "disability" criteria. Individuals with sufficient work experience may qualify for Medicare by reaching age 65 or meeting income and "permanent disability" standards (15). RW is mandated to be a "payer of last resort" and targets uninsured and underinsured HIV-infected individuals, particularly those who have not yet progressed to AIDS. Its federal budget is set annually by Congress, and some state legislatures provide supplementary annual appropriations. The largest components of RW spending are state-administered AIDS Drug Assistance Programs (ADAPs), which finance HIV medications (14, 17). We distinguish between discretionary and entitlement programs in our budget impact analysis because entitlement program budgets automatically expand in response to increased case load. Due to their discretionary structure, RW budgets are more vulnerable to unexpected increases in the number eligible for care.
HIV patient eligibility for public insurance programs fluctuates over time. Patients detected early in their disease may not initially meet disability criteria to qualify for Medicare or Medicaid; however, they may later transition from a discretionary to an entitlement program with age or development of symptomatic illness. In contrast, patients identified late in their disease may be immediately eligible for an entitlement program.
Wherever possible, we adhered to the ISPOR guidelines on budget impact analysis (12). We used a published Monte Carlo state transition simulation model of HIV testing, disease, and treatment to estimate incremental testing and treatment costs for prevalent and incident cohorts of HIV-infected individuals over a five-year time horizon. The testing cost calculations also include the cost of screening non-infected individuals. In conformity with the ISPOR principles (12), we selected a planning horizon that reflects the time frames used for budget planning in publicly financed HIV care (18). Our baseline horizon of five years matches the three to five year interval typical of RW reauthorizations. Recognizing that some readers may be interested in the budget impact over a longer time horizon, we alsoconsider a ten-year horizon in a sensitivity analysis. We examined two testing strategies: current practice (defined by completing a test, on average, every 10 years) and expanded screening (defined by completing a test, on average, every five years), and evaluated alternative testing frequencies in sensitivity analyses. The derivation of the testing time frames is described below. We also examined alternatives for the type of test, rate of return for test results and linkage to care, and likelihood of qualifying for a government testing and care program.
We report the following outcomes: the number identified over five years, the fraction of cases identified through presentation to care with testing versus clinical AIDS, mean CD4 count at diagnosis (a measure of immune function), the incremental quality-adjusted life years (QALYs), and costs to government programs. Costs were forecasted separately for programs that pay for HIV testing, discretionary treatment programs (including federal RW funds, state matching funds, and uncompensated care pools), and entitlement treatment programs (Medicare and Medicaid).
National data on health insurance coverage and HIV epidemiology were used to estimate the proportion of cases eligible for discretionary and entitlement programs at the time of HIV detection and over the subsequent five years. We report undiscounted dollar outlays in each budget period in 2009 dollars, which is consistent with ISPOR's recommendation to report undiscounted costs (12, 19).
We focused on adults (>18 years) due to our objective to project costs to RW, Medicaid, Medicare, and uncompensated care pools. Although RW does fund some services for children and youth, these funds represent a small percentage of overall RW grants (20). The federal and state-funded State Children's Health Insurance Program (SCHIP) would likely incur most of the costs of treating newly identified HIV cases among children and adolescents, and is not included in our budget analysis. Additionally, the clinical parameters in our model are derived from adult populations.
We tracked HIV-related treatment costs for all adults, including the elderly. We excluded testing costs for elderly adults (>64 years) because neither past screening efforts nor the revised guidelines target this group (5). All cost calculations also excluded patients for whom testing and treatment costs were likely to be financed through the VA or private insurance.
We used national estimates of insurance status to estimate the total number of non-elderly adults (aged 19 to 64 years) without private or VA insurance who would be eligible to receive HIV tests through a government testing program (21, 22). For modeling purposes, we assumed that only those eligible for public sector-financed care (excluding VA coverage) would receive a public sector-financed test. Sensitivity analyses include scenarios where additional costs are incurred by government programs to test or eventually treat individuals who are currently insured through private insurance or the VA. We used 2008 national HIV incidence data (approximately 56,000 new cases annually) (23) to project the total number of HIV-infected individuals potentially eligible for testing and linkage to care upon diagnosis. We used national HIV prevalence data (approximately 1.1 million prevalent cases, of whom 21percent do not know their infection status) (24) to calculate the number of prevalent cases currently aware of their infection and eligible for care. These data were also used to estimate the number of undetected prevalent cases potentially eligible for testing and linkage to care upon diagnosis. We assumed a constant incidence of new infections over the 5-year period (23). We estimated the fraction of all cases (detected and undetected) likely to qualify for government discretionary and entitlement programs using data from the HIV Research Network (HIVRN) (25). We used data on the incidence and prevalence of HIV among veterans to subtract those likely to receive care through the VA from our population estimates (26). Our calculations yield the following populations eligible for government-financed testing and treatment in 2009: 50,100,000 HIV-negative individuals; 711,000 prevalent cases aware of their infection; 189,000 undetected prevalent cases; and 46,000 incident cases. Further details of these calculations are provided in the technical appendix.
We assumed that treatment costs for newly diagnosed individuals without private or VA insurance are financed through discretionary programs until they qualify for Medicare by attaining age 65 or they experience an AIDS-defining opportunistic infection (OI), thereby qualifying them for Medicaid or Medicare. Newly diagnosed individuals may be immediately eligible for entitlement programs before presentation with an OI due to pregnancy, prior disability, or state-specific poverty-level expansions (14, 27). Because national estimates of this population are unavailable and the number is likely to be small, we did not account for such eligibility.
Table 1 displays the data sources used to generate demographic and clinical characteristics of cases eligible for government care upon diagnosis. We used a different set of characteristics for HIV-infected individuals in the three cohorts (prevalent aware, prevalent unaware, and incident cases).
The mean age, gender, and CD4 distribution for the prevalent aware cohort were obtained from summary data of all patients in the HIVRN study (28). We assumed that prior to ART, the distribution of viral loads after acute HIV infection for each CD4 stratum was similar to that of the Multicenter AIDS Cohort Study (MACS) cohort (29). We determined the distribution of prior OIs for each CD4 stratum through an initialization cohort, in which we simulated healthy cohorts with the same mean age and gender proportions until they reached each CD4 stratum (30). We assigned these patients to discretionary and entitlement programs based on insurance status reported in HIVRN.
By definition, demographic characteristics of prevalent unaware cases are unknown. We assumed that the age and gender of "prevalent unaware" cases were similar to that of "prevalent aware" cases. Untreated disease lasts on average ten years (120 months), of which the first two months are in the acute state, the last two years (24 months) are in the symptomatic chronic state, and the remainder of time (94 months) is spent in the asymptomatic chronic state. An undetected patient thereby had a 1.7% chance of being in the acute state (2/120), 78.3% chance of being in the asymptomatic chronic state (96/120), and 20% chance of being in the symptomatic chronic state (24/120) (8, 10). The mean CD4 distribution of acute cases was estimated from published studies of individuals with primary infection (31), and the mean CD4 distribution of chronic cases was estimated from the MACS cohort (29). We assumed that no patients had a history of OIs, as they otherwise would have been identified and linked to care upon presentation.
It is difficult to derive population characteristics of incident cases because these cases are not immediately detected. We derived the mean age of new cases through back calculation. Past research has estimated that on average, there is a duration of eight years between infection and presentation to care (32). We subtracted this value from data on prevalent cases to calculate the mean age of 33 years for the incident cohort (10). All individuals in this cohort entered the model at the time of infection, during an acute state of illness. Clinical characteristics included no OI history and a very high viral load (>100,000 copies/mL). The mean CD4 distribution of this cohort was estimated from published studies of individuals with primary infection (31). After individuals progressed past the acute state (approximately two months), their viral load decreased and patients were moved to a lower viral load stratum. The viral load distribution was derived from the MACS cohort (29).
The Cost-Effectiveness of Preventing AIDS Complications (CEPAC) Model is a widely published computer simulation of HIV disease and treatment (8, 33-35). It contains two components. The Screening Module simulates an HIV screening program and determines when each simulated HIV-infected patient will become detected through testing or presentation to care with an AIDS-defining OI. For those detected through testing, the Screening Module additionally determines whether they were effectively linked to care. The Disease Module tracks the clinical progress of all patients, irrespective of whether they have been detected; however, only patients that have been successfully detected and linked to care through testing or AIDS-defining presentation are eligible for treatment.
The Screening Module allows user-defined inputs on test characteristics, testing frequency, linkage to care, and costs. We simulated cohorts of currently unidentified incident and prevalent cases likely to qualify for government care upon detection, as described above.
In the base case, patients were screened using the rapid HIV test. Many health departments have implemented rapid tests, and there is evidence of a shift from conventional (ELISA) to rapid technologies (36) because patients can receive preliminary results at the time of testing.
The Disease Module uses a Monte Carlo state-transition framework to track the natural history of illness in simulated patients with user-specified care. Data sources and details are described in the technical appendix. Simulated patients undergo monthly transitions among health states, categorized by chronic illness, acute illness, and death. Monthly probabilities of events include changes in CD4 counts and HIV viral load, the development of an OI, adverse drug reactions, and death related to OIs, chronic AIDS, or non-AIDS-related causes. Summary statistics are collected for each simulated patient on age, mean projected survival, cause of death, OIs, the length of time spent in each health state, and cost. Simulated patients may receive antiretroviral therapy, medications for treatment and prevention of OIs, and ongoing routine care.
Table 1 summarizes the sources used to tabulate costs. We adapted testing costs from a recent analysis conducted by CDC researchers (37), which updates earlier studies (38, 39). Cost estimates are consistent with recent literature that reports economic outcomes of HIV testing in emergency departments (40-43). All screened individuals were assigned the cost of the test, irrespective of their HIV status. Those with preliminary positive tests (true and false positives) additionally incurred the cost of a confirmatory test. All individuals were assigned the cost of post-test counseling, which differed by test result. Post-test counseling costs for HIV-infected persons included costs to facilitate linkage to care. Not all individuals received their test results; those who did not receive them did not incur costs for confirmatory testing and post-test counseling.
Prior to the CDC's revised screening guidelines, pre-test counseling was encouraged. The current guidelines promote opt-out testing, without separate written consent and pre-test counseling (5, 7). In practice, legal requirements for pre-test counseling and written consent vary by state (44). Furthermore, some testing sites may continue to offer pre-test counseling in the absence of a requirement. In order to simulate the CDC guidelines as closely as possible, we excluded pre-test counseling costs from the base case analysis of both screening scenarios. We included these costs in a sensitivity analysis, and we assumed that providers' decisions to offer pre-test counseling were independent of the testing frequency. The CDC's revised recommendations for opt-out testing are controversial (6, 11). We assumed that if individuals who did not receive pre-test counseling changed their risk behavior, the cost impact to government programs would be minimal in our five-year time frame, although they may become significant in future years.
Pharmaceutical costs were calculated using published average wholesale prices (45), which were adjusted for the average state Medicaid reimbursement rate by weighting state-specific Medicaid discounts by AIDS prevalence (46). Costs of laboratory tests were derived from the Medicare fee schedule (47). Medical care utilization of patients at different stages of HIV disease were obtained from data collected by the HIV Research Network (HIVRN) (46). Costs of inpatient services were derived from the University HealthSystem Consortium database (46, 48).
We conducted separate simulations for three groups of patients and aggregated the results. The first group is the 711,000 prevalent cases eligible for entitlement and discretionary programs and receiving care in 2009. The second group is the 189,000 prevalent cases whose infection is undetected in 2009 and who will not incur costs to the government programs until they are detected and linked to care. The third group is the 46,000 incident cases eligible for government care each year, who will also only incur treatment costs upon detection and linkage to care.
To model current practice, we estimated that on average, individuals receive a test every 10 years, equivalent to a 0.83 percent chance of being tested each month and 5.0 million tests annually. This estimate is derived from a CDC analysis of national health data surveys (49), although other surveys suggest that current screening rates may be higher (50). We validated our estimate by comparing our model results to CDC estimates that 39 percent of HIV-infected individuals received an AIDS diagnosis within a year of their first HIV test (51). We found that our current practice of once every 10 years reasonably approximated these data on late presentation to care.
To model expanded screening, we assumed that on average, individuals are offered and accept a test every five years, equivalent to a 1.67 percent monthly chance of testing and 10.0 million tests annually. This represents a two-fold increase in testing from current practice. Although this test rate does not match the CDC's recommendation for routine screening in the general population and repeat annual testing for high-risk populations (5), we believe that it best represents the population effect of reasonable efforts to implement the policy. Prior analyses of expanded HIV testing have also used a five-year testing frame (8, 9).
In the base case for current practice and expanded screening, we assumed that 97 percent of patients received their rapid test result (52), and that 80 percent of all identified cases were successfully linked to care (53, 54).
To examine if our results were robust to parameter uncertainty, we conducted extensive sensitivity analyses, listed in Table 1. One set of analyses used the ELISA test, which differs from the rapid test with respect to costs and the rate of receipt of test results. We varied the testing frequency, from a minimum of "no testing" to a maximum of "annual testing." We varied the rate of receipt of rapid test results from 90 percent to 100 percent, and receipt of ELISA results from 50 percent to 100 percent. We estimated a range of linkage to care probabilities (for identified cases who had received their results), from perfect linkage (100 percent) to 50 percent linkage. We assessed the cost impact of including pre-test counseling. We calculated the impact of a 10 percent increase in the population eligible for government-financed testing and care if additional costs are incurred by government programs to test and treat individuals who are currently privately insured but have incomplete coverage or lose coverage in the future. Finally, we considered a ten-year time horizon.
Table 2 displays clinical characteristics of newly-identified HIV-infected adults eligible for government-financed testing and care (excluding the VA), for the base case of each screening scenario. If testing continues at an average frequency of once every ten years, 177,000 cases (116,000 prevalent; 61,000 incident) will be identified from 2009 to 2013. Over the course of their lifespan, 68 percent of currently unidentified prevalent cases and 49 percent of incident cases will receive a diagnosis after presenting to care with an AIDS-defining OI. If expanded testing increases testing to once every five years, an additional 46,000 cases (17,000 prevalent; 29,000 incident) will be identified from 2009 to 2013. The fraction of cases receiving a diagnosis as a result of an AIDS-defining OI will drop to 58 and 32 percent for prevalent and incident cases, respectively. The mean CD4 count at detection (a measure of HIV disease progression) will be higher under expanded screening for all cases, reflecting earlier detection.
Table 3 lists the projected total testing and care costs to public payers, under each screening scenario. Costs are separated by program type (testing, discretionary, and entitlement) and then summed at the bottom of the table. In the base case, continued testing at the current rate will incur a total cost of $83.7 billion over five years. Expanded screening will incur an additional cost of $2.7 billion, for a total of $86.4 billion. Five-year testing costs will increase from $504 million to $1.0 billion. Budget projections are dominated by treatment costs. Testing costs represent a small fraction of total costs (0.6 percent and 1.2 percent for the current practice and expanded screening scenarios, respectively) and 18.3 percent of additional costs for expanded screening. Five-year projected costs to discretionary programs will increase by $2.9 billion (from $26.0 billion to $28.9 billion), which will be partially offset by a savings of $624 million in the entitlement program budget. In both scenarios, most costs will be incurred by entitlement programs.
Under a ten-year time horizon, 158,000 cases will be identified under current practice (19,000 prevalent; 139,000 incident) in the second 5-year period from 2014 to 2018. Over time, an increasing number of incident cases are identified via current practice as they progress through HIV disease and develop OIs. However, continuing expanded screening for the additional 5 years yields an additional 31,000 cases identified between 2014 and 2018. Compared to current practice, expanded screening will yield incremental costs of $1.1 billion to testing programs and $10.9 billion to discretionary programs, and incremental savings of $2.8 billion to entitlement programs.
Figure 1 shows annual incremental costs for people identified through expanded screening. In each budget year, expanded screening would incur an additional screening program cost of approximately $101 million. This incremental cost remains constant. The projected annual incremental cost of care to discretionary budgets would rise throughout the period, from $133 million in 2009 to $983 million in 2013. Entitlement programs will experience cost savings, which will increase over time. We project annual savings of $2 million in 2009 and $280 million in 2013. Incremental costs to discretionary programs are not fully offset by cost savings to entitlement programs.
Figure 2 displays the projected pharmaceutical costs to discretionary programs under current and expanded screening in comparison to the 2007 RW AIDS Drug Assistance Program (ADAP) budget (inflated to $2009), including federal and state contributions (17). In the first year, pharmaceutical costs to discretionary programs would be about $3.2 billion under both scenarios, in comparison to the 2007 ADAP budget of $1.5 billion. By 2013, the annual pharmaceutical cost would increase by $0.2 billion under current screening and $0.8 billion under expanded screening.
Results of sensitivity analyses are shown in Table 3. Using ELISA tests will decrease testing costs to $384 million and $766 million for current practice and expanded screening, due to the lower test cost and return rate. Inclusion of pre-test counseling will increase testing costs to $699 million and $1.4 billion for current practice and expanded screening. Perfect rates of test return and linkage to care would increase total care costs to $83.8 billion for current practice ($26.9 billion discretionary; $56.9 billion entitlement) and $86.5 billion for expanded screening ($30.3 billion discretionary; $56.2 billion entitlement). Low rates of test return and linkage to care would decrease total care costs to $82.1 billion for current practice ($24.6 billion discretionary; $57.5 billion entitlement) and $83.5 billion for expanded screening ($26.5 billion discretionary; $57.0 billion entitlement).
Combining these sensitivity analyses, we estimate that the high-cost scenario (rapid test with pre-test counseling and perfect rates of test return and linkage to care) will incur total testing and care costs of $84.5 billion and $87.9 billion for current practice and expanded screening, for an incremental cost of $3.4 billion. The low-cost scenario (ELISA test with no pre-test counseling and low rates of test return and linkage to care) will incur total costs of $82.4 billion and $84.3 billion for current practice and expanded screening, for an incremental cost of $1.9 billion.
If there is a 10 percent increase in the population eligible for government-financed testing and care, total costs will increase to $92.0 billion under current practice and $95.1 billion under expanded screening, for an incremental cost of $3.0 billion.
Both cost-effectiveness and budget impact analysis can inform policy decisions (12, 55, 56). Due to the fragmented US healthcare delivery system, the societal perspective used in CEA may not apply to public payers. Healthcare dollars are often earmarked for specific purposes, and decision-makers have limited capacity to determine how and when to spend budgets.
The CDC considered economic evidence in formulating its recent recommendation to increase HIV testing in routine care (7) but did not estimate total costs (11). Peer-reviewed literature has described the potential of the CDC's screening guidelines to be cost-effective (8, 9), as well as the cost-effectiveness of other testing policies (11). However, government budget outlays for the CDC's policy are unknown. We projected the budget impact of doubling testing rates from once every ten years to once every five years. Although testing every five years does not perfectly match the CDC recommendation, our aim was to project the budget impact of the policy as it is likely to be implemented.
Expanded screening will increase the costs of HIV testing and care to government programs by $2.7 billion over five years. This increase is large in comparison to the annual RW budget ($2.1 billion per year) (20). It is smaller relative to the total entitlement budget for HIV care (annual federal budgets of $6.3 billion for Medicaid and $3.2 billion for Medicare) (16, 27). In both current practice and expanded screening strategies, HIV testing represents a small fraction of total costs. The downstream pathway of costs triggered by expanded screening and the cost-shifting that will occur between entitlement and discretionary programs are important budget concerns.
Discretionary programs such as RW will be most affected by expanded screening. Pharmaceutical costs will be the main driver of budget increases, as antiretroviral medications represent nearly three-fourths of lifetime HIV care costs (46). An expanded screening program will impose an additional pharmaceutical cost to discretionary programs of $1.9 billion over the five-year period, which is equivalent to 25 percent of the current ADAP budget if it remained constant during the time period. RW has been flat-funded since 2000 despite higher HIV case counts (57). Congress earmarks a portion of RW funds for ADAP and many states supplement their federal allocations with local contributions (20). However, budget constraints have already forced many states to implement ADAP cost-containment strategies such as wait lists, copayments, reduced drug formularies, and restricted eligibility (17).
As the expanded screening program increases HIV care costs to discretionary programs, costs to entitlement programs will decrease slightly. Cost savings to entitlement programs will be very small in the first year but will increase over time. Some cost savings are due to earlier detection of cases, with averted OIs and hospitalizations. Additionally, earlier detection will cause cost-shifting from entitlement to discretionary programs. On average, newly-identified cases will incur fewer treatment costs than previously diagnosed cases, owing to the fact that they will tend to be younger and healthier, less likely to initiate antiretroviral therapy, and more likely to be initially assigned to discretionary programs.
We project that an increase of $503 million in the budget for government-financed testing programs would be required to implement expanded screening, which is larger than the $53 million budget increase proposed for all CDC HIV prevention and surveillance work in the next fiscal year (58). If expanded screening were implemented consistent with the CDC guidelines, the policy may not be feasible without additional funds from state and local governments.
RW is scheduled for reauthorization later this year. Activists argue that RW, particularly ADAP, is chronically under-funded (59); this is confirmed by our results which show that even under current rates of testing, projected discretionary pharmaceutical costs surpass the ADAP budget. If expanded HIV screening increases demand for discretionary programs as we project, RW will be further under-funded and unable to cover the costs of those eligible for services. Expanding Medicaid services to low-income individuals who have not yet progressed to AIDS may alleviate some demand for RW (16). Congress has intermittently considered – but not enacted – the Early Treatment for HIV Act, which would give states the option to extend Medicaid benefits (60). Although entitlement programs generally respond more readily to increased demand, it may be politically challenging to enact legislation to shift costs from discretionary to entitlement programs. Policy-makers may want to consider the downstream care costs of expanded HIV screening as they deliberate RW's reauthorization.
One set of assumptions may have underestimated costs. We did not account for new drugs or technologies, or future changes in treatment guidelines towards earlier initiation of antiretroviral therapy, all of which may increase care costs. We assumed that privately insured individuals retain their coverage, are not under-insured, and are ineligible for government-funded care. We further assumed a constant percentage of newly-identified individuals with private or VA coverage. However, as the epidemic continues to move disproportionately into underserved populations, fewer new cases will have existing coverage. Individuals with private insurance may transition to public programs as they exhaust their benefits or age. Additionally, the weak economy has increased the number of individuals eligible for government programs, as individuals lose employer-based coverage (61). It may be infeasible for government-funded HIV testing centers to exclude individuals with existing coverage. We addressed these limitations through a sensitivity analysis in which we increased the population eligible for government-financed testing and care. Our analysis did not include the budget impact of testing and care costs for youth, even though the CDC guidelines included this group. We also did not explicitly budget the costs of scaling up outreach programs such as the National HIV Testing and Mobilization Campaign (62), because the focus of the CDC recommendations are routine screening in healthcare settings.
Other assumptions may have overestimated costs. We did not model patients dropping out of care or discontinuing antiretroviral therapy. Results did not incorporate financial benefits of preventing HIV transmission to potential partners. While any reduction in the number of secondary infections will likely reduce long-term treatment costs, the magnitude of these cost reductions over a five-year horizon may not be perceptible (10). We did not account for potential economies of scale with higher testing rates.
Our data sources have several limitations. First, it is difficult to obtain precise population estimates of HIV-infected individuals in the VA. Second, although HIVRN includes sites from multiple regions, its data may not be nationally representative. Third, existing observational data do not allow us to assess whether the mix of unaware and aware cases differs by insurance status.
Another limitation is our failure to report year-by-year changes in the demographic composition (e.g., age and sex) of new HIV cases identified. These would provide a fuller description of the impact of alternative screening strategies.
Our analysis ignores the fact that individuals self-select into HIV testing. There is reason to believe that there exists a population of individuals who chronically refuse HIV testing. This group might be large if the CDC guidelines were attempted in earnest. In the emergency department context, for example, it is hard to test more than 10 to 20 percent of potentially eligible patients (40, 53). Differences in risk characteristics between refusers and accepters are currently unknown. Furthermore, there are limited data from these settings on test acceptance conditional on prior refusal. The budget impact of hard-to-test populations warrants further analysis.
All budgets were estimated on an aggregate national basis, rather than to specific states. Because Medicare is a federal program, administrative decisions are often made at the national level. In contrast, RW and Medicaid are primarily administered by states. Consequently, there is substantial interstate variation in program management and service delivery. Variation in eligibility for RW and Medicaid may result in cost-shifting across these programs at the state level. Additionally, the actual unit cost of services and medications to government programs differs nationally due to variation in pharmaceutical prices obtained by state ADAPs, the extent to which state programs pay insurance premiums to fund individuals' care rather than incurring direct costs, client cost-sharing, and reimbursement rates to providers (17, 63). We ignored interstate variation because our goal was to predict aggregate US costs, rather than the budget impact for specific states. Assessing the budget impact of interstate differences in program administration is an important area of future research.
Finally, the budget impact of expanded HIV screening may be influenced by the recent health reform legislation. Nearly all U.S. residents living with HIV will be insured after 2014. Those below 133% of the federal poverty level will be eligible for Medicaid, and the remainder will most likely be enrolled in the insurance exchange, have employer-based coverage, be enrolled in Medicare, or have access through federally qualified health centers (FQHC). We anticipate that RW budgets will be affected. Although our analysis is relevant to current decision-making, this major policy change warrants future research.
Expanded screening can identify new HIV cases and facilitate early entry to care, but also treating these individuals will increase budget requirements for government programs by $2.7 billion. The burden will fall disproportionately on discretionary programs, because persons identified with HIV early are less likely to be immediately eligible for entitlement programs. Expanded HIV screening will not meet early treatment goals unless government programs have sufficient budgets to conduct testing and provide care for newly-identified cases.
We are grateful to Kenneth Freedberg for making available the CEPAC Model and its associated resources, Caroline Sloan for her technical assistance, and Mark Schlesinger, Patricia Keenan, and Haiqun Lin for helpful comments on an earlier draft.
Financial support: This work was supported by the National Institute on Drug Abuse (R01DA015612), the Agency for Health Research and Quality (T32HS017589), the National Institute of Mental Health (R01MH65869 and R01MH073445), the National Institute of Allergy and Infectious Diseases (R37 AI042006), and the Doris Duke Charitable Foundation (Clinical Scientist Development Award).
This technical appendix supplements the methodological details in the manuscript text. We provide additional information on the Disease Module and Screening Module, detail the source data for the Disease Module, describe the incident and prevalent cohorts modeled in the analysis and derive their population estimates, describe HIV screening protocols and detail how these costs were tabulated in the analysis, and clarify how we differentiated entitlement and discretionary costs. Portions of the Disease Module description have been previously published elsewhere (1-4).
The Cost-Effectiveness of Preventing AIDS Complications (CEPAC) Model is a widely-published computer-based model of chronic HIV disease (1-5). It uses a Monte Carlo state-transition framework to track the natural history of illness in individuals. "State-transition" means that the model characterizes patients' natural history of illness as a sequence of monthly transitions from one health state to another. "Monte Carlo" refers to a random number generator and set of estimated probabilities that are used to determine the sequence of transitions among health states.
Clinically, HIV-infected individuals experience a rapid rise in the HIV viral load within the first few weeks of exposure. Acute infection may manifest with flu-like symptoms in up to half of patients. However, this syndrome is self-limited and often does not present to medical attention or lead to HIV diagnosis. With resolution of acute infection symptoms, viral load declines to a "steady state." Undetected HIV-infected individuals then remain in a period of asymptomatic infection with progressive immunologic decline and continued viral replication for almost a decade. In the absence of HIV testing during the asymptomatic period, patients generally present to medical care with an opportunistic infection (OI) or other HIV-related illness such as renal insufficiency. Patients whose HIV infection is detected may benefit from antiretroviral therapy (ART), which acts to suppress the viral load, increase immune system function, and deter poor HIV-related outcomes (6).
The CEPAC Model simulates the clinical disease process as follows. Simulated patients undergo monthly transitions among mutually exclusive health states, categorized by primary HIV infection, chronic illness, acute illness, and death. States are further subdivided into six unique CD4 strata (>500 cells/mm3, 301-500 cells/mm3, 201-300 cells/mm3, 101-200 cells/mm3, 50-100 cells/mm3, and ≤50 cells/mm3) and seven unique HIV RNA (viral load) strata (>100,000 copies/mL, 30,001-100,000 copies/mL, 10,001-30,000 copies/mL, 3,001-10,000 copies/mL, 501-3,000 copies/mL, 51-500 copies/mL, and ≤50 copies/mL). Patients are at risk for the following opportunistic infections (OI) that lead to temporary states of acute illness: Pneumocystis jiroveci pneumonia (PCP), toxoplasmosis, Mycobacterium avium complex (MAC) disease, disseminated fungal infection, cytomegalovirus, and bacterial and other infections. Monthly probabilities of events include changes in CD4 counts and viral load, the development of OIs, adverse reactions to medications, and death. The viral load level determines the rate of CD4 cell decline in the absence of antiretroviral therapy (ART) or in patients who have failed ART, and the CD4 count predicts the monthly risk of OIs.
Investigators may specify the number, efficacy, and cost of sequential regimens of ART. In the model, ART decreases viral load. The reduction in viral load promotes CD4 rebound, thereby decreasing the risk of developing an OI.
Summary statistics are collected for each simulated patient on all clinical events, the length of time spent in each health state, and the associated costs and quality of life. A large cohort (usually around one million) is simulated until estimates are stable. Investigators input user-defined initial population distributions of demographic and clinical characteristics, including age, sex, CD4 count, and viral load. Investigators also specify the number of sequential lines of available ART, starting criteria for drug therapy, efficacy, and cost of treatment. Other user-defined clinical inputs include the timing and effectiveness of prophylaxis and treatment for OIs and the frequency of ongoing laboratory monitoring (CD4 counts and HIV RNA tests) and routine clinical visits. Table 4 lists additional details on these inputs. There are over a thousand inputs in total and we do not reproduce them all here. A full set of inputs is available to interested readers upon request.
A separate Screening Module has been designed to simulate the clinical impact of counseling, testing, and referral (CTR) on incident and prevalent patients who are unaware of their infection status at the start of the simulation (3, 7). The Screening Model is a front-end structure that determines when each simulated patient will become detected through screening or presentation to care with an OI. For those detected through screening, the Screening Module additionally determines whether they were linked to care. All patients (detected and undetected) have their clinical outcomes tracked through the Disease Module. However, only those who have been successfully detected and linked to care are eligible for treatment and incur costs. The Screening Module allows for input assumptions on testing frequency, linkage to care, rates of return for results, clinical characteristics of undetected populations, test performance characteristics (such as sensitivity and specificity), and cost.
National testing rates were translated into monthly probabilities of test receipt using a binomial approximation. For example, an annual test was simulated with a monthly test probability of 1/12. We assumed that all undetected patients with an OI would present to care and learn of their infection status during the treatment episode.
All clinical data for the Disease Module were derived from published literature, including the Multicenter AIDS Cohort Study (MACS), randomized clinical trials, and cohort studies. Data from MACS were used to model the natural history of disease (8), including the probability of chronic AIDS death for each health state, the probability of primary infection with an OI, and the probability of death from an OI. Cohort studies were used to derive the probability of secondary infection with an OI (9-16). The monthly probability of non-AIDS deaths was calculated from the U.S. life expectancy tables (17). The monthly baseline CD4 decline was derived from clinical literature (18). The efficacy of each antiretroviral regimen was estimated from published clinical trials (19-25). The full set of parameters is available from the authors upon request.
Patients initiated ART at CD4 < 350 or upon development of an OI, in accordance with DHHS guidelines (26). Patients were offered six sequential lines of therapy, with decreasing effectiveness. Patients who were observed to fail on one line of therapy were switched to the subsequent line in the following month. Failure was defined as an observed increase in viral load or a 50 percent decrease in CD4 count for two consecutive months. Data on the efficacy of the ART regimens (measured by rates of viral suppression) were derived from clinical trials (19-25). We reduced the efficacy of ART regimens, as reported in clinical trials, by 15 percent to account for lower efficacy between observational cohorts and clinical trials (19, 27). Prior to the start of each new regimen, patients received an HIV drug resistance test, in accordance with DHHS guidelines (26). Patients received OI prophylaxis therapy in accordance with national recommendations (28). Data on the efficacy of OI treatments and the probabilities of prophylaxis-related toxicity were derived from clinical trials (13, 29-36). Viral load and CD4 counts were measured every three months, in accordance with the guidelines (26).
We modeled three distinct cohorts: 1) prevalent cases aware of their infection status at the start of the simulation ("prevalent aware"), 2) prevalent cases unaware of their infection at the start of the simulation ("prevalent unaware"), and 3) incident cases. The first cohort was modeled using the Disease Model. The latter two cohorts were modeled using both the Screening Model and Disease Model; patients in these cohorts were only eligible for treatment upon successful detection and linkage to care. We assumed that all incident cases are unaware of their infection until they are detected in the Screening Model. To calculate the number of patients eligible for government programs, we used national estimates of prevalence and incidence and subtracted the number of HIV-infected individuals likely to receive care through private insurance or the Veterans Administration (VA), as described below.
The CDC estimates that there are 1,106,000 cases of HIV in the U.S., of whom 21% do not know their infection status (37). This yields 874,000 prevalent cases aware of their infection ("prevalent aware") and a maximum of 232,000 prevalent cases who could potentially be identified through a screening program ("prevalent unaware"). The VA cares for approximately 33,400 cases (38). Of patients enrolled in HIVRN sites, 15.4% have private insurance (pooled across years) (39). The HIVRN sample excludes veterans. We calculate the number of "prevalent aware" cases with private insurance as 15.4%*(874,000-33,400) = 129,000. The number of "prevalent aware" cases currently eligible for care through discretionary or entitlement programs is the total population (874,000) minus those receiving care through the VA (33,400) and private insurance (129,000), which equals 711,000.
The actual number of individuals who seek government-financed care may be larger than our estimate if there is a decrease in the number of individuals with private or VA insurance, or if some individuals are under-insured. We address this variable with a sensitivity analysis in which we increase the population eligible for testing and care by 10 percent. The upper bound for the prevalent aware estimate is 747,000.
We assumed that the fraction of "prevalent unaware" cases that would be eligible for care through the VA or private insurance would be similar to the payer distribution of "prevalent aware" cases. Patients without private insurance may have fewer encounters with the healthcare system, in which they might receive an HIV test. If this were true, "prevalent unaware" cases would be more likely to be eligible for discretionary or entitlement programs, compared to "prevalent aware" cases. Our assumption of a similar payer distribution would thereby result in a conservative estimate of the budgetary impact to public payers. We addressed this issue in a sensitivity analysis, in which we increased the number of cases eligible for publicly financed healthcare by 10 percent.
To estimate the number of "prevalent unaware" cases eligible for care through the VA upon detection, we assumed that the probability of awareness of HIV status among veterans is similar to the U.S. population (79%). The 33,400 "prevalent aware" VA cases would correspond to 33,400*(0.79/0.21) = 8,900 "prevalent unaware" VA cases. As described above, we estimated the number of "prevalent unaware" cases with private insurance as 15.4%*(232,000-8,900) = 34,400. The number of "prevalent unaware" cases currently eligible for care through discretionary or entitlement programs is the total population (232,000) minus those likely to receive care through the VA (8,900) and private insurance (34,000), which equals 189,000. In our sensitivity analysis, we used an upper bound of 198,000.
We used the CDC's recently updated estimates of national HIV incidence (revised from 40,000 to 56,300 new cases annually) (40). If the fraction of incident cases receiving care through the VA and private insurance is similar to the fraction among "prevalent aware" cases, then 2,200 of incident cases would be eligible for VA care and 8,300 would be eligible for private insurance upon detection. The number of incident cases currently eligible for care after detection through discretionary or entitlement programs is the total population of incident cases (56,300) minus those likely to receive care through the VA (2,200) and private insurance (8,300), which equals 45,800. The number of individuals who seek a government-financed test may be larger if it is difficult in practice to exclude those with alternate insurance sources from public testing facilities. In our sensitivity analysis, we used an upper bound of 48,100.
In contrast to the two static prevalent cohorts, a new incident cohort arrives during each budget year. To estimate the budgetary impact of incident cohorts, one run was performed to capture annual costs for a single newly-infected cohort. These costs were repeated for each subsequent budget year, with the arrival of a new incident cohort. The total cost in each year was the summation of the annual costs of the cohorts. Similar to cost calculations on the prevalent unaware cohort, we only tabulated costs of incident cases who have been identified. New cases are not linked to care in the model until detection.
We tabulated HIV screening costs for non-elderly adults eligible for discretionary or entitlement programs only (aged 19 to 64) in order to reflect the revised guidelines' focus on this group (41). We tabulated treatment costs for all adults (aged 19 or greater) eligible for these government programs, including the elderly. As less than 3 percent of HIV-infected individuals are 65 or older (42), seniors comprise a small share of total treatment costs. However, the effectiveness of current therapies makes it possible for those infected and identified to live into late adulthood, thereby incurring costs to Medicare.
Data from the Henry J. Kaiser Family Foundation (KFF) were used to derive the number of non-elderly adults eligible for a government-financed HIV test (43). Of the 261,400,000 non-elderly individuals (including children) in the U.S., 16% (41,800,000) are enrolled in Medicaid or other public insurance and 17% (44,400,000) are uninsured. Of the 78,600,000 children in the U.S., 29% (22,800,000) have Medicaid or other publicly-funded care and 11% (8,600,000) are uninsured. Subtracting the number of children from the former estimates yields 19,000,000 non-elderly adults (aged 19 to 64) enrolled in Medicaid or other public health programs and 35,800,000 non-elderly uninsured adults.
We used data from the VA (44) to remove the number of non-elderly veterans from this estimate. The VA estimates there are 7,800,000 veterans enrolled in the VA healthcare system, of whom 39% (3,100,000) are elderly. We assumed that the number of veterans under 19 years of age was negligible. Subtracting the VA non-elderly population (4,700,000) from the KFF estimates yielded a total of 50,100,000 non-elderly adults in the U.S. who would be eligible for an HIV test financed through a public program. In practice, program coordinators at HIV prevention centers may be unable to either exclude those with private or VA insurance from HIV testing or obtain reimbursement through these sources. We addressed this in a sensitivity analysis, in which we increased the number of cases eligible for government-financed testing to 55,100,000.
There are several reasons why HIV-infected individuals may not access care: first, they may not know they are infected, and second, they may know their infection status but have not been linked to care. We account for both of these issues in the screening module. As discussed above, 21 percent of individuals do not know they have been infected (37). This is incorporated into our estimates through the N calculations described above. Some individuals receive a test but do not return for results, and this test return varies by test type (45). Of those who are identified, clinical data suggest that approximately 80 percent are linked to care (46-48). Incomplete test receipt and linkage to care is incorporated into the screening module input parameters and is described in greater detail below.
In the base case, we modeled a one-step rapid test with two steps for a positive result, as described in prior cost-effectiveness analyses (49-51). After a patient consents to testing, a provider collects a specimen and a laboratory technician processes the sample. If the result is positive, a second specimen is collected and sent to an outside laboratory for a Western blot confirmatory analysis. Patients must return to receive results during a second visit. All patients receive post-test counseling at the time of their test results. For HIV-positive patients, post-test counseling includes assistance with identifying follow-up care. Approximately three percent of patients do not wait to receive results of their rapid test during the initial visit (45), which we indicate in Table 1 as a 97 percent "test return rate." Of those who receive their positive rapid test results, four-fifths are successfully linked to follow-up HIV specialty care (46, 48), which we indicate in Table 1 as an 80 percent "probability detected case linked to care." We assumed confirmatory tests had perfect sensitivity and specificity, an assumption used in other cost analyses (51).
In a sensitivity analysis, we modeled a two-step enzyme-linked immunosorbent assay (ELISA) with four steps for a positive initial result (49-51). In contrast to the rapid test, patients do not receive preliminary results during the first visit. Upon consent, a provider collects a specimen which is sent to an outside laboratory for analysis. If the specimen tests positive, a technician will repeat the ELISA twice (for a total of three ELISA tests) and perform a subsequent Western blot. Patients must return for a second visit to receive their results and post-test counseling. Due to the two-visit process, there is a higher rate of non-return for the ELISA than the rapid test: approximately three-fourths of those with positive readings and two-thirds of those with negative readings return for their results (45). Table 1 differentiates between the test return rates for positive and negative results. We assumed that those who received their positive ELISA test results had the same probability of being linked to care (80%) as those who received their positive rapid test results.
The assignment of screening costs is displayed graphically in Figure 3. All patients incurred the initial screening costs. HIV-infected individuals in the acute state (the first two months of infection) were assumed to remain undetected because they do not have detectable antibodies (6), unless they received a false positive antibody result and were subsequently identified by confirmatory testing. This occurred with probability 0.1%, obtained by subtracting the test specificity (99.9%) from 1. A small fraction (0.4%, determined by the test sensitivity) received a false negative result. All individuals incurred the costs of post-test counseling upon receipt of their positive or negative test results. Patients testing positive on the initial test incurred costs for additional laboratory testing, post-test counseling, and linkage to care. All costs were derived from micro-cost data presented by Farnham (51), adjusted for inflation using the medical care component of the CPI (52). Government payers incurred additional administration costs for patients who did not return for their results, which included mailing reminder letters or making phone calls. We assumed these costs totaled 30 minutes of staff time and $1 for materials (mailings and phone calls).
Screening costs for HIV-negative individuals were calculated deterministically based on test characteristics. All patients incurred the initial screening costs. The small fraction (0.1%, determined by the test specificity) receiving a false positive result incurred costs for subsequent confirmatory testing and post-test counseling but not linkage to care. Patients testing negative on the initial test incurred post-test counseling costs if they received their results. Patients who did not return for their results incurred an administration cost. All costs except for the non-return cost were derived from Farnham (51).
As described in the manuscript, we assumed that the treatment costs for all currently undetected patients (incident and "prevalent unaware") were incurred by discretionary programs until they developed an OI or attained age 65, at which point their care was financed through an entitlement program. We used these markers as a proxy for gaining eligibility for Medicaid or Medicare on the basis of disability or age.
We allowed currently detected patients ("prevalent aware") to start the simulation in either a discretionary or entitlement program. As with the incident and "prevalent unaware" cohorts, patients enrolled in a discretionary program became eligible for an entitlement program when they developed an OI or attained age 65. We used national data to assign the fraction of the "prevalent aware" cohort to each program. Among patients currently enrolled in HIVRN, 28.7% receive care financed by RW or are uninsured, and 55.9% receive care through Medicare or Medicaid (39). Using the calculation method described above, we estimated that 241,000 of the "prevalent aware" cases were eligible for care through a discretionary program at the start of the simulation, and that the remaining 470,000 were immediately eligible for care through Medicare or Medicaid.
We differentiated between discretionary and entitlement costs using two sets of simulations. The first set of simulations tracked all costs. The second set of simulations used identical inputs except that costs terminated in the month following detection with an OI or attainment of age 65. This second set of simulations represented costs to discretionary programs. The difference between these cost outlays represents the costs to entitlement programs.
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