text:
Disclosed is a computerized method for identifying peaks corresponding to glycans from a mass spectrum. At least one glycan spectrum is received from a mass spectrometer, with each glycan spectrum including peaks having a measured mass. Glycan identifications are automatically assigned to each of the peaks and these assignments are then reported.
1. A computerized system for assigning glycans to mass peaks in mass spectra of said glycans, comprising:
a processor configured to perform operations of:
receiving at least one mass spectrum of at least one glycan, wherein at least one of said peaks in said at least one mass spectrum corresponds to a measured mass of said at least one glycan;
constructing a monosaccharide set table for possible glycans, wherein at least one row represents the monosaccharide composition of at least one possible glycan;
applying a set of rules generated for the at least one glycan based on experimental and/or biosynthetic conditions, which limit the number of the potential glycans;
eliminating rows from the monosaccharide set table which do not satisfy said set of rules;
calculating at least one theoretical mass for at least one remaining glycan in the monosaccharide set table; and,
assigning at least one glycan to the at least one peak by comparing said measured mass to said theoretical mass.
2. The computerized system according to
3. The computerized system according to
assigning a confidence score relating to the accuracy of the glycan assignment;
creating a glycan report consisting of the cartoon representation of each corresponding peak with the assigned confidence score; and
reporting to a user the combined peak assignments and cartoons in the form of a glycan report.
4. The computerized system according to
5. The computerized system according to
6. The computerized system according to
defining matches between theoretical masses and spectrum peaks which have a high confidence;
obtaining a tolerance interval for matching from the defined matches; and
calibrating spectra using said tolerance interval.
7. The computerized system according to
8. The computerized system according to
9. The computerized system according to
10. The computerized system according to
11. The computerized system according to
This is a divisional of U.S. Ser. No. 10/696,814, now U.S. Pat. No. 7,402,438 filed Oct. 30, 2003, by the same inventors, and claims priority therefrom. This divisional application is being filed in response to a restriction requirement in that prior application and contains re-written and/or additional claims to the restricted subject matter.
The following U.S. patent applications are fully incorporated herein by reference: U.S. Patent Application No. 2002/0102610 ("Automated Identification of Peptides"); and U.S. Patent Application No. 2003/0027216 ("Analysis of Proteins from Biological Fluids Using Mass Spectrometric Immunoassay").
This disclosure relates to computer-mediated devices and methods for automated interpretation of data obtained by mass spectrometry in order to identify carbohydrates, particularly carbohydrates covalently bonded with proteins.
Since the genes in an organism encode the list of proteins that the organism manufactures, in principle the complete genome sequence of an organism provides a complete list of proteins in that organism. However, proteins are often modified after they are constructed from the gene (DNA) template, and these modifications have biological significance. Perhaps the most important class of modifications is the addition of small carbohydrates (glycans) to the protein. An example illustrating the importance of these modifications are the human blood groups, which result from the attachment of glycans to molecules on the surface of blood cells. A key problem in proteomics is the identification of these glycans. However, no practical automated method for identifying these glycans is currently available. Such a method would facilitate the labeling of peaks in a spectra and the identification of patterns that may not be readily observed from a non-automated process.
The disclosed embodiments provide examples of improved solutions to the problems noted in the above Background discussion and the art cited therein. There is shown in these examples an improved method and system for identifying peaks corresponding to glycans from a mass spectrum, which may provide some or all of the following features. At least one glycan spectrum is received from a mass spectrometer, with each glycan spectrum including peaks having a measured mass. Glycan identifications are automatically assigned to each of the peaks and these assignments are then reported.
In another embodiment there is disclosed a computerized system for identifying peaks corresponding to glycans from a mass spectrum. The system includes a spectrum receiver for transmitting spectrum files to the system, with each spectrum file including a set of masses (or mass ranges) and the ion frequency for each mass (or mass range). A maketable module constructs a monosaccharide set table, in which each row of the table represents a set of monosaccharides. An identification module develops a listing of mass peaks in the spectrum which match a row from the monosaccharide set table. A summary module structures a glycan report. Memory modules include a monosaccharide set table module, a peak identification file module, a cartoon library, in which reside symbolic representations of specific isomers, and a glycan report file module
In yet another embodiment, there is disclosed an article of manufacture in the form of a computer usable medium having computer readable program code embodied in the medium. When the computer executes the program code, the computer is caused to perform method steps for identifying peaks corresponding to glycans from a mass spectrum. At least one glycan spectrum is received from a mass spectrometer, with each glycan spectrum including peaks having a measured mass. Glycan identifications are automatically assigned to each of the peaks and these assignments are then reported.
The foregoing and other features of the embodiments described herein will be apparent and easily understood from a further reading of the specification, claims and by reference to the accompanying drawings in which:
As used herein, the term "mass spectrometer" refers to a device able to volatilize/ionize analytes to form vapor-phase ions and determine their absolute or relative molecular masses. Suitable forms of volatilization/ionization are laser/light, thermal, electrical, atomized/sprayed and the like or combinations thereof. Suitable forms of mass spectrometry include, but are not limited to, matrix Assisted Laser Desorption/Time of Flight Mass Spectrometry (MALDI-TOF MS), electrospray (or nanospray) ionization (ESI) mass spectrometry, or the like or combinations thereof.
As used herein, a "display" means any device or artefact that presents information in a form intelligible to a human observer and includes, without limitation, a computer terminal, a computer screen, a screen upon which information is projected, and paper or other tangible medium upon which information is temporarily or permanently recorded, whether by printing, writing or any other means.
As used herein, "list" means a computer-readable representation of data. A list may be implemented as any desired data structure, including without limitation a table, stack or array. A list may if desired be stored as a file or as a plurality of files.
As used herein, the term "protein" means any one of a group of large organic molecules containing chiefly carbon, hydrogen, oxygen, nitrogen and sulphur and consisting of unbranched chains constructed from a set of approximately twenty different amino acids, with one or more such polypeptide chains comprising a protein molecule.
As used herein, the term "carbohydrate" means any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds, including monosaccharides, disaccharides, oligosaccharides, and polyssaccharides
As used herein, the term "glycan" means polymers of more than about ten monosaccharide residues linked glycosidically in branched or unbranched chains.
As used herein, the term "isomer" means one of two or more compounds having the same molecular formula but different structures.
As used herein, the term "isotope" means one of two or more atoms having the same atomic number but differing in atomic weight and mass number.
This disclosure provides a system and method for automating the identification of glycans from a mass spectrum. In a sample of glycans processed through a mass spectrometer, the program identifies the glycans present in the sample by labeling the peaks in the spectra with cartoons of the glycans they represent. Some important features of the program are (1) it doesn't require the biologist to estimate the accuracy of the spectrum analyzer—this may be determined automatically; (2) glycan assignments may be associated with a confidence score; (3) the set of possible glycans is customizable. This last capability is desirable, since the set of possible glycans is different in different organisms (or even different tissues within a single organism).
Turning now to the drawings, wherein the purpose is for illustrating the embodiments of the system and method, and not for limiting the same,
It will be recognized that a computing environment may include various modules, such as a processing unit, system memory, a system bus coupling various system components to the processing unit, an input/output system, a hard disk drive, an optical disk drive, program modules, program data, monitor, various interfaces, peripheral output devices, and/or networked remote computers. However, for the purpose of clarity,
Typically the spectrum received from the spectrum analyzer is in the form of a digital representation of a histogram. For each mass (or mass range) the digital representation contains a count of the ions or a number proportional to the count, measured in that range. For the purposes of example, following is a sample digital representation for part of an example spectrum:
Summary component 130 reads peak identification file 160 and utilizes cartoon library 180 to associate a cartoon with corresponding peaks, then summary component 130 creates a glycan report, which may be sent to a print file or saved as glycan report file 170.
The cartoon library 180 includes cartoons, or symbolic representations, for rows from the monosaccharide set table, with each cartoon represented as a drawing, which may have associated program code. While some rows in the table will not have a cartoon, others may have more than one, as is illustrated in
In developing the cartoon library 170, an initial set of cartoon archetypes is loaded into the library by the user. From these cartoon rules are used to generate a much larger set. These rules may be structured such that they rarely generate a biosynthetically implausible cartoon. For example, two sample rules are
"A NeuAc can always be replaced by a NeuGc" and
"If there is a single fucose at the reducing end of a glycan, it can always be removed"
The rules may not necessarily directly correspond to a biosynthetic pathway. Instead they may take a set of cartoons and reduce it to a single exemplar and a rule for generating the rest of the set. Note that the rules may need to be applied repeatedly. For example, if a glycan has two sialic acids, then the first rule generates three variants: NeuAc/NeuAc, NeuAc/NeuGc, and NeuGc/NeuGc. The rules may be species or tissue specific.
Returning to
Turning now to
Turning now to
Turning now to
In more detail, taking high-confidence peak identifications and the measured relative difference between observed and predicted masses of the identifications yields two numbers a and b which can be used to decide if an observed peak should be assigned to a glycan. An assignment is accepted if the observed mass and theoretical mass of the glycan satisfy
Currently, high confidence identification of a peak with a glycan means
The peak is intense—it's one of the 200 highest peaks.
The mass of the peak is within a tolerance t of a theoretical glycan mass m.
The isotope envelope closely matches the theoretical one.
There are no significant peaks near mass m−1.
Another possible criterion would be to require that the theoretical glycan be on an approved list of commonly occurring glycans.
Using the relative difference Δ between theoretical and observed peaks,
One example approach to compute the constant a in equation (1) hereinabove:
1. Set the tolerance t to 300 ppm
2. Find all high confidence peaks that are within t of the theoretical glycan mass, that is |Δ|<t.
3. If there are fewer than 15 such peaks, replace t with 2t and go back to step 2.
4. Compute the relative difference Δ for each high confidence peak and compute the median Δmed of all the Δ's. This is a measure of calibration error and is a first estimate for the constant α.
5. Apply an adjusted formula for Δ that takes into account the calibration error
6. Repeat steps 4 and 5 until they resolve to provide a consistent value of Δmed. Then set α=Δmed.
One possible approach for determining a reasonable value for b is achieved by setting t to 10 ppm and increasing it in increments of 10 ppm, for each t a set {Δi} of the relative differences of the peaks within tolerance t is computed. In trying to detect the point at which the Δi's no longer reflect the natural noisiness of the mass spectrometer, a point may be reached at which peaks are included that are incorrect assignments. If this "breakdown" occurs for t=t0, then b is set to b=t0.
This "breakdown" may be detected as follows:
For each t, an χ2 test is performed on the resulting Δi to determine if their distribution is normal. If there is a sudden jump in χ2 at t=t0, the b is set to b=t0. Otherwise the spread of the Δ's is determined by computing their standard deviation s. For each t, t/s is computed. If there is a value t0 at which t/s has a pronounced maximum, then b is set as b=t0. Otherwise b is selected to be the point at which the standard deviations s seem to reach a plateau. After the spectrum is calibrated, peak assignments are made at 520. Working from the table of isotopes, each entry in the monosaccharide set table is examined, to find a match in the spectrum. This is accomplished by selecting the isotope of each isomer with the highest expected frequency, and then searching the spectrum for a peak within an acceptable tolerance of that isotope. If several possible peaks match within an acceptable tolerance, the peak that gives the best isotope envelope (more precisely, the one with the lowest S score) is selected. This generates a list of assignment of peaks to glycans.
A sample output of peak identification may appear as follows:
Peak identification may optionally include quality assessment, as shown at 530. If this option is selected, each assignment is rated based on a quality score measurement, which determines the likelihood that the assignment is correct. This is based on several factors:
1. Proximity of the measured mass of the peak to the theoretical mass of the glycan. This may be measured by
2. Computation of the isotope envelopes. Theoretical frequencies fi were computed when the monosaccharide set table was constructed. For each peak of mass m, the peak heights at m, m+1, . . . m+5 are checked and converted to frequencies f′i. The observed and theoretical frequencies are compared using
3. Examination of m−1 peak. If a peak occurs at m−1, the height of this peak is checked. A smaller peak height is an indication of confidence in the assignment.
Although these factors may be combined into a quality number, they may also be utilized in a binary form to indicate a suspect peak. A peak is suspect if either
if the isotope sum S>0:30, or
if the height of the peak at m−1 is greater than one-half the height of the highest theoretical isotope peak of the glycan.
In the case in which the spectrum contains peaks for two glycans of nearby mass, the isotope rule may be modified to distinguish nearby glycans.
Another possible option within peak identification is spectrum combination at 540. In a case in which multiple spectra are available, it is possible to combine the information in them to learn more than could be gained from a single spectrum. Although several analyses are available for this case, two examples are described for the purposes of illustration.
Turning now to
While the present discussion has been illustrated and described with reference to specific embodiments, further modification and improvements will occur to those skilled in the art. Additionally, "code" as used herein, or "program" as used herein, is any plurality of binary values or any executable, interpreted or compiled code which can be used by a computer or execution device to perform a task. This code or program can be written in any one of several known computer languages. A "computer", as used herein, can mean any device which stores, processes, routes, manipulates, or performs like operation on data. It is to be understood, therefore, that this disclosure is not limited to the particular forms illustrated and that it is intended in the appended claims to embrace all alternatives, modifications, and variations which do not depart from the spirit and scope of the embodiments described herein
It will be appreciated that several of the above-disclosed and other features and functions, or alternatives thereof, may be desirably combined into many other different systems or applications. Also that various presently unforeseen or unanticipated alternatives, modifications, variations or improvements therein may be subsequently made by those skilled in the art which are also intended to be encompassed by the following claims. Unless specifically recited in a claim, steps or components of claims should not be implied or imported from the specification or any other claims as to any particular order, number, position, size, shape, angle, color, or material.
Patent Citations
Non-Patent Citations
Original Image


text:
Gunmetal Black Ep 01
episode 14.26 / 5.00 4,912 Views
Lucina's First Day
A look at the first day of Lucina in Super Smash4.24 / 5.00 15,750 Views
BATMAN v SUPERMAN final showdown
SPOILERS!!4.19 / 5.00 14,453 Views
You deserve my five stars. I cant believe this is so funny. Especially The Charlie scene and Bison, Balrog and Vega's argument. Classy XD
Thanks. Sadly not many people got the jokes. :/
Really funny, but I dont understand the "Ryu wins the tournament" scene. Just plain strange. Everything else is funny though.
That final sketch was originally about Ryu singing a J-pop song called "Pop Star" by Ken Hirai, but due to copyright claims in Youtube I had to remove it and replace it whith Guile's theme since it goes with everything.
So blame Sony Music for ruining the joke. :/
Makes me Wanna be a PopStar!
Absolutely Hilarious.
One of the best vids i've seen, thank you for making this everyone!!

subset: commoncrawl


text:
Patriots keep winning even when offense falters
But they didn't score a touchdown after the first six minutes of the second quarter against Miami.
"We didn't convert as often as we like," Brady said.
But they did that when they had a chance to close out the game. Leading 20-13, the Patriots got the ball with 8:28 and didn't give it back until just 1:10 remained. That 16-play, 77-yard drive lasted 7:18 and led to a field goal that made it a two-possession game.
That mattered a lot more to Belichick than the poor production earlier.
"We don't go into any game thinking, 'It's going to be this way or it's going to be that way. This is going to be a 50-49 game or it's going to be a 3-2 game or that kind of thing,'" he said. "Ultimately, at the end, it comes down to being able to make the plays you need to make to win the game."
They did that Sunday.
"We've been in those situations before where we've thrown up a lot of big numbers," Belichick said, "or scored some points and then get to that (late) point in the game and go three-and-out."
Avoiding that could be critical next Monday night when Houston visits.
The Texans (11-1) currently have the top seed in the AFC with the Baltimore Ravens second. The Patriots must pass one of them in their four remaining regular-season games to get a first-round bye.
So coordinator Matt Patricia knows his defense will have to keep playing well against Houston.
"You're talking about a very balanced, very well-put-together offense," he said.
If the game is close, Belichick hopes his team can come up with big plays down the stretch, just as it did in Miami.
"That's what I'd like to see from an offense or a defense or any part of your team for that matter, to make the critical plays that you need to make to win the game," he said. "That's really what it's all about, not a bunch of stats."
Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL


text:
Health Starts Here Cooking Class
- Food & Drink
- 5600 Magazine Street, New Orleans, LA, 70115
Yoga at the Station!
Whole Foods Market Arabella Station
Thursday, September 4, 2014 from 6:30 PM to 7:30 PM (CDT)
Join us for a Free, Community Outdoor yoga class. Every Thursday from 6:30p-7:30p on our patio, weather permitting. This class is open to all levels. Mats and water provided.
Whole Foods Market on Magazine Street is located in the old Arabella Station street car barn. This charming building is only the start of the fun! Come on in and meet our knowledgable team members who are sure to brighten your day!
Join millions of people on Eventbrite.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


text:
For those who view college as simply an entrance requirement to a job, the logic goes something like this:
"A girl's gotta eat, and to eat I need a good job, and to get a good job, I need a college degree, or in most cases, degrees. I don't have the luxury of taking Philosophy or Art classes for fun, or Physics just to see how the world works."
Check out this school in HARLEM..they get it…]]>
Where is your sacred space? If you don't have one, why?
Is sacred space a place God dwells and humans should not enter?
Is sacred space a place you go to reconnect with the infinite, to receive inspiration, to realign yourself with your spiritual values, or….?
When was the last time you spent more than 30 seconds in or near your sacred space?
What benefit does spirituality give our lives? Is it important to create sacred space in our lives?]]>
What a great send-off for Letterman, and a delicious stab at what women "have" to do to appear acceptably attractive, particularly in show business.
How many women reading this own any Spanx? When was the last time you wore something to cinch you in? Job interview? Wedding? Prom? Going someplace you knew an Ex, or a Future Ex might be? How do you feel about it now?
Saturday Salons are great places to take a fresh look at what we accept as normal behaviors, or things we can not change, then realizing after the Talking Stick makes a few rounds, how laughable our cultural norms are!]]>
The original owner, Ms. Masefield, long since gone, turned down big bucks in order to stay in her little bungalow, defying the corporations who built towering concrete and steel structures intimidatingly up and around her home. She just sat there smiling until she died. Gotta love that woman!
A North Carolina investment company has it now, after a subsequent owner defaulted on the mortgage.
What do you think? Was Ms. Masefield admirable or just some crazy old lady?
Saturday Salons are a great place to take a topic in the news and use it as a catalyst for meaningful discussions about what is happening in your own life, like where the boundaries should be between independence and community, or corporations and individuals.
Here in Orange County, CA, people take turns complaining about the cookie-cutter, stucco suburbs, while still enjoying the numerous bike paths and parks that city planning created alongside those cookie-cutter, zero lot line houses.
Just taking this one topic-city planning – here are some questions to throw in the hat for your next Salon:
Throw Alexis de Tocqueville's famous quote into the hat:
"In a democracy, people get the government they deserve."
Do you agree?
He also said, "I know of no country in which there is so little independence of mind and real freedom of discussion as in America."
Host a Saturday Salon…!
I agree with Tocqueville only in that we still have the freedom, we just don't use it.]]>
A deeper question for the Saturday Salon hat may deal with how our belief systems affect our feelings and actions, or if they reach that far? When faced with tragedy, does your religion truly comfort you or cause you to take certain actions over others?
We know what our various religions say we SHOULD think, but do we? Buddhists are supposed to take comfort in knowing everything is temporary. Reality itself is a matter of perception, constantly changing and rearranging. If we truly accept that, change of any kind will not phase us, even death, pain or illness. Christians are supposed to take comfort in prayer, asking God to intervene on their behalf, or at the very least, they accept horrible events such as a child's death, because things are supposed to be better in the next life – the balance sheet will be reconciled and all will be well.
What do you believe, and how deeply do you believe it? Do you believe strongly enough to truly be comforted during times of unwanted change?]]>
Old age creeps up on most of us. First, we give up jogging or dancing because of our knees. Then, we start forgetting where we put our car keys. Friends our age have heart attacks. Even the women. Our parents die. But first, they usually go through an illness-often cancer. Some beat it for a time, but eventually, it seems to get everyone in the end. And that's not even listing the mental and emotional illnesses people suffer.
Not a very cheerful smattering of thoughts.
So, what are our options? Do we have examples of people whose lives continue to have meaning, who continue to have joy even when they are in physical pain, have lost mobility, or are hooked up to machines?
SATURDAY SALON QUESTION: How are you preparing yourself for old age, or a catastrophic accident that leaves you suddenly, severely limited, such as the military vets who lose limbs? What will you do, or are you doing now, to have meaning in your life? To feel joy? To serve others?
What makes life meaningful?
It seems we have three choices.
Let's say political corruption or partisan divide and deadlock is your pet peeve. You hate it, you call your spouse over to see the latest abomination on the news, and your blood pressure goes up every time you see CNN or FOX News. But…what do you do next? You can…
1) stew in your juices, and do nothing but remain upset 24/7.
2) become preppers and move to a compound in Idaho with multiple automatic weapons.
3) think about what you want and how it could be achieved, either by you individually, or by finding or creating a group you could actively work with to achieve the changes you want to see. Do some research. Think outside the box. Believe change is possible. Live a meaningful life.
I'm for option 3.]]>


text:
Paris Hilton to Ditch Loser Friends, Turn Life Around
Paris Hilton says she's turning her life around. We'll believe this when we don't see her having sex with Stavros Niarchos and thumbing her nose at everyday people on The Simple Life.
But celebrity gossip source TMZ is taking the jailbird so seriously that it's compiled a list of those the heiress should bid farewell to. Here are some recommendations:


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30 year old man | Indianapolis, IN, USA | Seeking women 21-35 within 50 miles
Active within 1 hour
Since I just turned 30, I figured I would...
Since I just turned 30, I figured I would update this since I haven't in awhile. The basics: I went to IU. I've been working for the same company in finance ever since I graduated. I bought a house when I was 26. I can seem quiet when you first meet me but can be the life of the party once I get to know you. I have a small, close group of friends and still have best friends that I've known since 6th grade. Outside of work, I'm often at the gym. It's more of a habit than anything and it doesn't hurt to look and feel fit. You won't find me posting any selfies on Instagram or checking into the gym everyday just to let everyone know though. I'm a huge IU basketball, Pacers, and Colts fan and it wouldn't be unusual for me to schedule my day around a game.
Camping , Dining out , Movies/Videos , Music and concerts , Exploring new areas , Nightclubs/Dancing , Playing cards , Playing sports , Travel/Sightseeing , Video games , Watching sports
Basketball, Weights / Machines
I exercise 3-4 times per week.
I love the beach although I'd love to go back to Europe someday.
Indiana University Bloomington, Bloomington, IN
music, technology, sports (Colts, Pacers, IU basketball, and the Cubs)
Love anything water related. Going to the gym. Concerts. Watching movies. Any sporting event. Music and concerts. Traveling.
Gone Girl and Wolf of Wall Street (before the movies came out)
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|6'0" (182cms)
|5'0" (152cms) to 5'8" (172cms)
|Body type:
|Athletic and toned
|Slender, About average, Curvy, Athletic and toned
|Blue, Brown, Green, Hazel
|Light brown
|Black, Light brown, Dark brown, Blonde, Dark blonde
|No Way
|No Way, Occasionally
|Social Drinker
|Never, Social Drinker, Regularly, Moderately
|Financial / Accounting / Real Estate
|No preference
|I'll tell you later
|No preference
|Never Married
|Never Married
|Have kids:
|Wants kids:
|Definitely, Someday
|White / Caucasian
|Asian, Latino / Hispanic, White / Caucasian
|Christian / Catholic
|No preference
|English, Spanish
|No preference
|Bachelors degree
|High school, Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


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44 year old woman | Oklahoma City, OK, USA | Seeking men 40-50 within 15 miles
Active within 24 hours
Just looking around...Anyone fun out there??
I am just checking this whole thing out. I am not sure how this works or if it's even right for me. BUT, I am willing to try anything once!! I have had a few friends meet some great people on here. Maybe I will at least meet some great friends! I'm living my life the best way I know how to, laughing as much as I can, and loving every moment of it. Honestly, I'm not that hard to please. I'm a free-spirit. I'm strong and determined. I'm the girl who will burst out laughing- in the middle of silence- at something that happened the day before. I love to look up at the stars, and secretly, I still wish upon the first one that I see at night. I live for those moments and feelings that can't be put into words. I love and adore my parents, my precious friends, my AMAZING 21yr old SON and my pets. I love them so much that it hurts. (And I like it that way). My life is brilliant and my love is pure. Here is what I believe: Be with those who make you smile. Laugh as much as you breathe. It's never too late to try something new, so pick up a new hobby, explore fresh ideas, do something crrrazy! or make a new friend. Be a dreamer AND a doer. DANCE in the rain, cherish the memories, love and learn, forgive, trust, SAY YES, order dessert, gripe less, say what you feel, do what you want, sing out LOUD, take pleasure in the little things. Take time to BREATHE and appreciate the beauty around you. It's everywhere. Apologize when you should, LET GO of what you can't change, KISS slowly, PLAY hard, take chances, GIVE Everything! Have no regrets. Life is too short to be anything but Happy. OH, And if all else fails, wear cute SHOES!
Cooking , Dining out , Movies/Videos , Music and concerts , Exploring new areas , Volunteering , Watching sports , Wine tasting
Aerobics, Cycling, Dancing, Swimming, Walking / Hiking, Weights / Machines, Yoga
I exercise 3-4 times per week.
I have Dogs
Middle of the Road
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'1" (154cms)
|5'7" (170cms) to 6'5" (195cms)
|Body type:
|About average
|No preference
|No preference
|Light brown
|No preference
|No Way
|No preference
|Social Drinker
|No preference
|Other profession
|No preference
I work for a local professional sports team
|I'll tell you later
|No preference
|No preference
|Have kids:
|Yes, and they sometimes live at home (1)
|No preference
|Wants kids:
|No, but it's OK if my partner has kids
|No preference
|White / Caucasian
|White / Caucasian
|Spiritual but not religious
|No preference
|Bachelors degree
|No preference


text: yes that is true. i have an fe2 and it is a very good and solidly built camera. the only qualm i have is that the meter doesnt work until you have advanced until frame 1 and before that the shutter is stuck on mechanical 1/250. other than that, dont hesitate!


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West Market Square in Downtown Bangor Grand Re-Opening Tonight
The Retrorockerz will be providing the tunes for tonights kickoff Cool Sounds Concert with a special ceremony to officially re-open the newly renovated square.
The Retrorockerz will be providing the tunes for tonights kickoff Cool Sounds Concert with a special ceremony to officially re-open the newly renovated square.
Summer and a holiday that falls on the weekend means that there will be a lot of people on the roads. The Maine State Police will be ramping up its enforcement of speeding, distracted driving, and seat belt laws. And they've put together a video that lists the top 10 reasons for distracted driving. Do you do any of these?
The media is often full of upsetting, and sometimes depressing news. So why not lighten things up with some jokes? It's 'International Joke Day' so here are our best Maine jokes!
With police continuing to search for accused murderer Robert Burton, and the holiday weekend upon us, measures are being taken to warn vacationers about the search area. A press conference is planned for Thursday to update the media about the search.
Someone on the Internet decided to remind everyone that Freddie Mercury was a better singer than Kanye West could ever hope to be.
You know how people have special skills they put on their resume? This probably doesn't fall into that category.
Rihanna hasn't released a new studio album in almost four years, but she stills sells more records than pretty much everyone else.
You know, cars with four wheels are just so passe.
Deputies in Penobscot County arrested a pair of suspects after a burglary at the Levant Corner Store on Route 222 Tuesday night.
The tribute to Miss Independent includes hits from 2002 until now.


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Discover a selection of top forums technika rush on the internet. Come to share your passion on forums technika rush and meet other fans of technika rush. Then, why don't you create your own forum of technika rush ?
Gaming Group for various video games. Cod, Battlefield, DayZ, Minecraft, you name it. . . we play it.
gaming, rushing, call, duty, first, person, shooter, xbox, clans, clean, arena, game, battles, #rush, social, network, cool, black, modern, warf
Pro-Liberty Politics & Rock 'n Roll!
arcade, mame, food, politics, kaptainsteve, swamp-ass, kinks, libertarian, thunders, racearena, ramones, davies, danbury, faces, small, rock, hannity, #rush, beck, glenn, limbaugh


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The series includes walking, bicycle and happy hour tours. Architects, curators, historians, and local professionals guide each tour. The series starts Memorial Day Weekend and runs through early September. Ticket prices are listed with each tour. Westcott members receive discounts to most tours. Tickets are available online and at the Westcott House Museum Store, 85 South Greenmount Street. Please be advised that many tours sell out. Advance ticket purchase is strongly recommended.
Saturday, May 23 at 10 am (guided by Ski Schanher) / Mobility 3
$10 General / $7 Members
Sponsored by Charlie Swaney
Ferncliff Cemetery, covering over 240 acres of rolling hills and pastoral landscape, was platted during the Civil War as Springfield's new burial ground. Join us to hear the stories of the men and women who built Springfield and discover its history preserved in stone. Our Ferncliff Cemetery Walking Tour has been a Memorial Day Weekend tradition since 2006. Meet at the Ferncliff Cemetery Chapel, 501 West McCreight Avenue.
Saturday, May 30 at 10 am (guided by Tom Taylor) / Mobility 3
$10 General / $7 Members
Sponsored by Mark Grimes
Founded in 1845 as an Americanist Lutheran College, Wittenberg has been a cornerstone of the Springfield community for over 170 years. It is also home to some of Springfield's best buildings, including Myers Hall, Recitation Hall, and Zimmerman Library. Join us as we explore this institution's remarkable history and distinctive architecture while meandering through acres of rolling, wooded landscape. Meet at the corner of West Ward Street and North Wittenberg Avenue.
Saturday, June 6 at 10 am (guided by Vicki Rulli and Tom Heaphey) / Mobility 2
$15 General / $12 Members
Sponsored by Esther Manuel
Dick Link and Andrew Hellmuth, then up-and-coming local developers, platted Westchester Park in 1953. Its rolling hills and strong deed restrictions made it an ideal neighborhood for the architect-designed modern home. Join us as we examine some of the best local works from the mid-century, including houses by Phil Snyder, Jack Kline and two show-homes by Better Homes and Gardens magazine. Meet outside Highlands Church at 1910 St. Paris Pike.
Saturday, June 13 at 10 am (guided by Cindy Catanzaro) / Mobility 1
$10 General / $7 Members
Sponsored by Richard and Joyce Spangler
Between 1908 and 1940, many Springfielders ordered their homes through mail order catalogs from companies like Montgomery Ward and Sears, Roebuck & Company. Join us as we explore the southern part of the Hills and Dales neighborhood, which boasts a collection of Sears kit houses, as well as competing styles from popular pattern books of the 1920s and 1930s. Meet at the corner of St. Paris Road and Snowhill Boulevard.
Saturday, June 20 at 10 am (guided by Jim Nash) / Mobility 1
$10 General / $7 Members
Sponsored by Larry Coressel and Liz Nelson
Elmwood Place, developed at the turn of the twentieth century by the Brain McGregor Real Estate Company, was once Springfield's most fashionable address. As such, it contains some of the region's best homes from the period. Join us as we stroll along this neighborhood's majestic streets, including tree-lined Arlington Avenue, and experience the tranquil setting of this idyllic suburban neighborhood. Meet at the corner of South Arlington Avenue and East High Street.
Saturday, June 27 at 10 am (guided by Kevin Rose) / Mobility 2
$10 General / $7 Members
Sponsored by Lois and Bob Christel
From the early 1850s to the end of the Civil War, the Hill was one of Springfield's most affluent neighborhoods. This changed, however, with the arrival of Champion Machine Company in 1868. Join us as we explore the Hill's early mansions, later working class housing, and the factories that precipitated the transformation. This tour will also pass the birthplace and childhood home of silent-film actress Lillian Gish. Meet at the corner of Linden and Monroe.
Saturday, July 18 at 10 am (guided by Kevin Rose) / Mobility 1
$15 General / $12 Members
Sponsored by Ski and Cheryl Schanher
The Progressive Era ushered in a new generation of leaders and entrepreneurs, whose spirit of innovation and civic responsibility contributed to Springfield's growth and national prestige. Join us as we examine their grand East High Street homes, including the Westcott House and Crowell Mansion, which stand today as a tangible reminder of their amazing success. Meet outside of the Westcott House, 1340 East High Street.
Saturday, August 8 at 10 am (guided by Rita Lane) / Mobility 2
$10 General / $7 Members
Sponsored by Paul and Cindy Valente
Columbus real estate developers Theodore Weyant and P.J. Guthrie developed Springfield's bucolic Hills and Dales neighborhood in 1915. Its scenic northern section, where charming streets meander through old growth forest, was a direct competitor to Harry Kissell's neighboring Ridgewood. Join us as we explore this neighborhood's picturesque wooded landscape and handsome homes. Meet at the corner of St. Paris Road and West Harding Road.
Saturday, August 15 at 10 am (guided by Jeff Smith and Richele Shepard) / Mobility 2
$10 General / $7 Members
Sponsored by Basil and Claudia Fett
Prominent Americans like Oliver S. Kelly, William N. Whitely, and Harry S. Kissell are just part of South Fountain's storied past. With their success, and that of their neighbors, South Fountain came to be recognized as a premier neighborhood for Springfield's affluent class. Today it is home to a new generation of community leaders. Join us to experience the renaissance of this National Register Historic District. Meet outside First Baptist Church at 638 South Fountain Avenue.
Saturday, August 29 at 10 am (guided by Kevin Rose and Scott Sanders) / Mobility 3
$15 General / $12 Members
Sponsored by Kevin Rose and Marta Wojcik
In 1944, Antioch College hired the celebrated architectural firm of Saarinen & Swanson to envision a modern campus that could meet the demands of increased enrollment following World War II. Over the next decade, amid the backdrop of the Red Scare and McCarthyism, Antioch reshaped its campus into a bastion of avant-garde design. Join us as we examine the modernist landmarks that fill this picturesque campus, including designs by Eero Saarinen and Skidmore, Owings & Merrill.
Saturday, July 11 at 10 am (guided by Vicki Rulli and Tom Heaphey) / Mobility 3
$10 General / $7 Members
Sponsored by Alan Ladd and Jake Studebaker
Modernism is not the first thing that comes to mind when we think of Springfield's north end, yet these historic neighborhoods contain a diverse and impressive collection of mid-century modern design. Join us on this bicycle tour as we examine pre-war International Style houses by Max Mercer, sleek Contemporaries by Jack Kline, all-metal Lustron homes, and a Usonian gem by Roger Montgomery. Meet at the corner of North Fountain Boulevard and Sunnyside Place on your bicycle.
Saturday, August 22 at 10 am (guided by Doug Bisher) / Mobility 3
$10 General / $7 Members
Sponsored by Gene and Mary Lynn Barnett
The Westcotts moved to Springfield in 1903 during a period of social and aesthetic reform known as the Progressive Era. Join us on this bicycle tour as we explore the world of Burton and Orpha Westcott from 1903 to the mid-1920s, including associated houses and factories, architecture influenced by the Prairie School, and the City Beautiful park concepts envisioned for Greenmount Cemetery. Meet outside the Westcott House, 1340 East High Street, on your bicycle.
Wednesday, June 10 at 6 pm (guided by Kevin Rose) / Mobility 1
$12, which includes one drink at Seasons Bistro and Grille
Sponsored by Pete and Sandy Hackett
At the end of the 19th century, local leaders understood that great architecture was part of their civic duty. With downtown as their canvas, architects painted a streetscape that exemplified Springfield's past achievements and future aspirations, including Warder Library (1890), City Building and Market (1890), and Bushnell Building (1893). Tour through Springfield's Golden Age of architecture. Meet outside the Heritage Center, 117 South Fountain Avenue.
Wednesday, July 22 at 6 pm (guided by Kevin Rose) / Mobility 2
$12, which includes one drink at Mela Urban Bistro
Sponsored by Suzy Turner
The urban fabric of Springfield's Early South End has changed dramatically over the past 150 years. Although the effects of urban renewal ravaged this once grand residential district, several historic architectural relics survived the wrecking ball. Join us as we examine the incredible early-Victorian mansions just south of downtown. Meet in the rotunda of the Clark County Public Library, 201 South Fountain Avenue.
Wednesday, August 12 at 6 pm (guided by Laurie Stanton) / Mobility 1
$12, which includes one drink at Buckeye Sports Lodge
Sponsored by Richele Shepard and Jeff Smith
As Springfield continues to redevelop downtown's west end, civic-minded citizens are re-examining the historic structures that have outlived urban renewal. With big projects in the works, there is renewed focus on several regional landmarks, including Crowell-Collier, the Masonic Temple, and the former Elks Building. Join us as we explore Downtown West's historic past and hopeful future. Meet outside the Masonic Temple, 125 West High Street.
Wednesday, August 26 at 6 pm (guided by Kevin Rose) / Mobility 1
$12, which includes one drink at Seasons Bistro and Grille
Sponsored by Ross McGregor and Cathy Crompton
Public Art was a vital component of the Core Renewal Campaign of the 1970s. Demolition of familiar buildings in the downtown core paved the way for sleek modern architecture, minimalist landscapes, and daring public art. This tour will explore several works of art, including David Black's Flipover and Ronald Bladen's controversial sculpture Oracle's Vision. Meet in the small park at the corner of South Limestone and East High Streets.
Wednesday, July 1 at 6 pm (guided by Kevin Rose) / Mobility 2
$10 General / $7 Members
Sponsored by John and Jill Landess
Local architects Lon Krider and Charles Cregar designed the Mast Mansion, popularly known as Castle Knoll, for Phineas and Anna Mast in 1882. This masterpiece of the Aesthetic Movement, built with locally quarried limestone and over eighteen varieties of wood, took three years to construct. Join us we explore the interior and exterior of one of Ohio's great Victorian castles. Meet at the Mast Mansion, 901 West High Street.
Tours and programs of the CA+D are developed for a broad audience, including those with disabilities and decreased mobility. Tours move at a leisurely pace with brief periods of standing at tour stops. If entering a building or house, some stairs or inclines may be possible. Please call or email for details regarding a specific tour.
Mobility Level 1
Up to 6 blocks walking, mostly flat terrain, paved, stairs not likely. Wheelchair accessible.
Mobility Level 2
May be more than 6 blocks walking, some hills, mostly paved, some stairs possible. Please call or email about wheelchair accessibility.
Mobility Level 3
Considerable walking, various terrains, unpaved areas. All bicycle tours. Please call or email about wheelchair accessibility.
To receive our brochure with all the information about each tour, please sign up for our mailing list.
Summer Tour Series is sponsored by:


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Amazing Video: Bear Climbs Tree, Sniffs Hunter In Tree Stand
Updated: 12/16/2013 - "So you want to bear hunt in Alberta, Canada? Better pack extra underwear!!"
Updated: 12/16/2013 - "So you want to bear hunt in Alberta, Canada? Better pack extra underwear!!"
Posted: 06/20/2013 - Wall Street suffered its worst day of the year Thursday, one day after Federal Reserve chairman Ben Bernanke raised fears the central bank may be preparing to wind down its stimulus policies this year.
Posted: 06/20/2013 - A border patrol spokesman says it's probable they are immigrants. Activists say border deaths are on the rise as security forces more dangerous crossings.
Posted: 06/20/2013 - Two things created this look on 3-year-old Grayson Clamp's face: his auditory brain stem implant and the words "Daddy loves you." Grayson became the first child in U.S. with an auditory brain stem implant.
Posted: 06/20/2013 - In the fun house mirror that is the U.S. stock market these days, bad economic news has had investors dancing a jig while good news is sending them fleeing for the exits.
Posted: 06/20/2013 - All 230 passengers and crew were killed when TWA flight 800, a New York-to-Paris flight, crashed July 17, 1996, shortly after takeoff from John F. Kennedy Airport.
Updated: 06/20/2013 - The Supreme Court has a little more than a week left to hand down its remaining rulings from this term, including four broaching the contentious issues of race and marriage equality.
Updated: 06/19/2013 - The new study shows rates of vaccine-type HPV prevalence dropped from 11 percent before the vaccine was introduced, to 5 percent by 2010 for 14 to 19 year-old-girls.
Posted: 06/19/2013 - Fed Chairman Ben Bernanke said Wednesday the U.S. economy continues to heal, but suggested that it is too soon to start tapering the central bank's $85 billion in monthly bond purchases.
Posted: 06/19/2013 - The man who played Tony Soprano on the HBO series, died suddenly of a heart attack Wednesday. He was scheduled to appear at the Taormino Film Fest in Sicily. Gandolfini is survived by his wife and son, and a daughter born just last fall.
Posted: 06/19/2013 - Country music singer Slim Whitman died of heart failure at 90 Wednesday. The yodeling singer gained fame in Europe as well as in the U.S.
Posted: 06/19/2013 - FBI says the hunt for Jimmy Hoffa is over, no body was found. Alleged mobster who tipped off police says he hopes his "good friend" is exhumed.
Posted: 06/19/2013 - Investigators at the Queens home have been searching for possible unidentified human remains. Investigators are looking into a case that happened before 1996.
Posted: 06/19/2013 - Mueller told the Senate Judiciary Committee on Wednesday that drones are used by the FBI in difficult cases, in a "very, very minimal way and very seldom."
Posted: 06/19/2013 - The Centers for Disease Control and Prevention estimates that 36 percent of American adults are obese. The American Medical Association is now officially calling it a disease.
Updated: 06/19/2013 - A local Eagle Scout lends his talents to an area fire department.
Posted: 06/19/2013 - There are probably a lot of reasons why a fifth of Americans can't find their own country on a world map...
Posted: 06/19/2013 - Rates of HPV strains related to genital warts and some cancers have decreased 56 percent among American teen girls since a vaccine was introduced in 2006, the Centers for Disease Control and Prevention reported Wednesday.
Posted: 06/19/2013 - The Federal Reserve said Wednesday that it will maintain the pace of its program to keep long-term interest rates at record lows, but offered a slightly more optimistic outlook for the U.S. economy and job market.
Posted: 06/19/2013 - Country singer Slim Whitman, the high-pitched yodeler who sold millions of records through ever-present TV ads in the 1980s and 1990s and whose song saved the world in the film comedy "Mars Attacks!," died Wednesday at a Florida hospital. He was 90.
Posted: 06/19/2013 - The American Medical Association has officially recognized obesity as a disease, a decision that could change the way physicians and insurance companies deal with the condition.
Posted: 06/19/2013 - The Afghan government said Wednesday it was suspending talks with Washington aimed at nailing down a future security agreement between the two nations.
Posted: 06/18/2013 - Congress has passed a GOP-sponsored bill banning so- called "late term abortions" - procedures for women who are beyond 22 weeks into their pregnancies.
Posted: 06/18/2013 - Hastings was a reporter for BuzzFeed, and is remembered for his Rolling Stone profile of Gen. Stanley McChrystal. The profile revealed rifts between Obama and his commanders. McChrystal abruptly retired after the article was published.
Posted: 06/18/2013 - The Security Assistance Force says four NATO coalition service members have been killed, and a spokesman speaking anonymously says all four were Americans.


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* required fields
Illinois moved into the top position for LEED certification with 171 projects representing 2.29 square feet of LEED space per resident, according to the USGBC's Top 10 States for LEED. The per-capita list is based on 2010 U.S. Census data and includes commercial and institutional green building projects that were certified throughout 2013.
The mid-Atlantic region reigned in 2013 with Washington, D.C., Maryland, and Virginia all topping the list. Washington, D.C., had 106 LEED-certified projects representing 32.45 square feet of space per resident. Maryland and Virginia followed Illinois in the second and third positions, respectively, certifying 2.20 and 2.11 square feet of LEED space per resident in 2013.
Newcomers to the top 10 states list from 2012 include:
Reflecting the continued trend of LEED existing buildings outpacing their newly built counterparts, in 2013 the LEED for Building Operations and Maintenance rating system accounted for 48% of total square footage certified in these states. This compares to 43% of square footage certified under LEED for Building Design and Construction and 9% certified under LEED for Interior Design and Construction.
The full ranking is as follows:
*Washington, D.C. is not ranked as it is a federal district, not a state.
Collectively, 1,777 commercial and institutional projects became LEED certified within the top 10 states in 2013, representing 226.8 million square feet of real estate. Worldwide, 4,642 projects were certified in 2013, representing 596.8 million square feet.
Visit our website today to learn about the design flexibility of a Morton building and the endless possibilities of partnering with our designBUILD team.
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When choosing a metal-clad building for your next construction project, consider Morton Buildings, Inc., and their designBUILD team, we'll make your dream a reality.
We Can Help You Reduce Energy by 30%
Our mission is to help our customers manage their buildings' energy costs, improve reliability, and enhance performance while having a positive impact on the environment.
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Sustainable parking leaders recognized.
Design 'scatters' sound without affecting aerodynamics.
Survey shows lack of concrete commitment to efficiency improvements.
Guideline will protect building water systems.
Development could mitigate urban heat island effect.
New web application can identify energy savings opportunities.
Report shows refrigerants could reduce GHG emissions, energy use.
Sustainable design tied to strong financial performance.
Human wellbeing guidelines grow throughout North America.
Larger, private buildings now included in rankings.
Diversion rates increase nearly 10% in 2013.
Surveyed workers feel unsafe, doubt employer readiness for weather events.
Better Buildings Challenge improvements demonstrate energy savings.
New technology provides privacy and sunlight.
Program will provide best practices, green certification for landscape design.
Improve recycling up to 20% with an easy switch.
OSHA and Health Canada to improve hazard communications for worker safety.
Lighting, building automation retrofits show highest rate of return.
New OSHA guide to ensure fair treatment, safe working conditions.
The Advocate AV-Series Lavatory System, now in 10 new colors, integrates soap, faucet and dual-sided hand dryer in a touchless, all-in-one solution. www.bradleycorp.com/advocate.
Need portable cooling? Call Number 1! Sunbelt Rentals now has North America's largest fleet of climate control equipment.
Spot Coolers commercial portable heating & cooling Nationwide Emergency service 24/7. Your source for portable air conditioning rentals and sales.
The BUILDINGS brand serves commercial building owners and facilities management professionals for commercial real estate. BUILDINGS brand offers its audience of commercial building owners and facilities management professionals information on the development, construction, modernization, management and operations of commercial buildings as well as the products and services needed to support such commercial buildings and facilities management. With the information we offer, we help facilities management professionals make smarter decisions for commercial buildings.
BUILDINGS delivers relevant and timely information that equips commercial building owners and facilities management professionals with the knowledge and support they need to solve critical issues; energy management, lowering operating costs, new products for commercial buildings, security, and much more.
BUILDINGS provides facilities management professionals commercial buildings tips and trends trough online webinar events (BuildingsVIP), monthly newsletters, whitepapers and case studies.
In addition to content, BUILDINGS features a comprehensive list of products and services and is your link to the companies that provide these valuable facilities management and commercial buildings resources.
You also have the opportunity to maintain your commercial buildings certifications with BUILDINGS. Continuing Education Units are available with approved content from BOMI.
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PAWTUCKET ŌĆō Rehabbing an injury can prove very tricky for many athletes to navigate successfully. ThatŌĆÖs why the athletic trainer is an important source, both in terms of offering moral support and aiding the athleteŌĆÖs quest to return to action as soon as the body permits.
In terms of both critical areas, Ryan Kalish knows heŌĆÖs in good hands with Jon Jochim, the trainer for the Pawtucket Red Sox. On Sunday morning, Kalish emerged from the trainerŌĆÖs room with his left shoulder heavily bandaged, tangible proof that another therapy session under JochimŌĆÖs care had transpired.
Resuming baseball-related activities may not be in KalishŌĆÖs immediate future ŌĆō the outfielder asked shortstop Jose Iglesias for assistance in sliding on the left sleeve of his warmup jacket ŌĆō yet he takes comfort during this period of uncertainty and frustration in knowing that Jochim is the right guy to get him back up to speed.
ŌĆ£He was my trainer in the Gulf Coast League [in 2006, the same year Boston selected Kalish in the ninth round], so we go way back,ŌĆØ said Kalish, sidelined since April 21 after making a head-first diving catch in center field went awry. ŌĆ£HeŌĆÖs super caring and itŌĆÖs really good to be with him here.ŌĆØ
Kalish also found himself under JochimŌĆÖs care last June after suffering from a strained right hip flexor. That injury resulted in the hard-charging outfielder missing 15 games, but his stay on the disabled list could have easily been extended had he not followed JochimŌĆÖs advice. By taking things slowly, realizing that strength to the tender spot would be restored in due time, Kalish returned with additional speed to burn. In fact, Kalish credits the exercises Jochim prescribed in paving the way for the player to become more of a game-changer on the basepaths (22 stolen bases in 90 games between Pawtucket and Boston).
KalishŌĆÖs latest setback has resulted in the term ŌĆ£range of motion.ŌĆØ What this starting-from-scratch procedure entails is plenty of stretching, this according to PawSox manager Arnie Beyeler.
ŌĆ£HeŌĆÖs got to let (the shoulder) heal first. Basically itŌĆÖs things that we take for granted as far as lifting your arm over your head and lifting your arm down below, then doing that across your body 10 times,ŌĆØ explained Beyeler. ŌĆ£You do it a little bit more each day so that when you become comfortable, you can add some weights.ŌĆØ
Added Kalish, ŌĆ£YouŌĆÖve got to loosen things up. IŌĆÖm trying to stay in shape, so IŌĆÖm in the gym every day, working on my lower body. ItŌĆÖs a process, just like anything else.ŌĆØ
Kalish quickly corrected a reporter when asked how his shoulder has progressed in the week-plus following his setback.
ŌĆ£Actually itŌĆÖs been ten days,ŌĆØ he said with a laugh. ŌĆ£I feel much better. IŌĆÖve gotten a lot of my strength back. There have been plenty of encouraging signs, but IŌĆÖve got to keep plugging away. Hopefully IŌĆÖll be good to go in a couple of weeks.ŌĆØ
Kalish mentioned that his therapy sessions with Jochim take place long before the regulars appear in the clubhouse. ThatŌĆÖs by design so that enough time is allotted to those on the active roster. Asked if there was talk of him heading down to Florida to rehab, Kalish responded no. If sticking close to Jochim had worked before, why bother deviating?
ŌĆ£I have a lot of good friends here, so itŌĆÖs good to be around them,ŌĆØ said Kalish about another benefit in remaining with the PawSox. ŌĆ£YouŌĆÖre watching a baseball game, and shoot, I can help these guys. For me, I can help someone with stealing bases if I see something. IŌĆÖm just trying to stay in the game.ŌĆØ
A player with Red Sox ties will kick off a rehab assignment Monday night at McCoy Stadium. However, the player-in-question will not be reporting to Boston upon completing his stint in the minors. Former Sox catcher Victor Martinez will join Toledo and serve as the Mud HensŌĆÖ designated hitter over the next two days, which would set up his return to Detroit quite nicely.
Signed by the Tigers in the offseason, Martinez is eligible to come off the disabled list on Wednesday. The switch-hitter has been sidelined since April 19 with a sore groin. For the season the 32-year-old Martinez is hitting .250 in 16 games.
The PawSox were involved in 14 transactions in April, a paltry sum considering that the club was involved in 26 transactions during the seasonŌĆÖs first month in 2009 and 20 last season. The monthŌĆÖs most notable moves came when pitcher Alfredo Aceves was scratched hours before his start on Opening Night, the addition of Felix Doubront to the staff and Kalish getting hurt.
Other than that, the roster Beyeler has worked with has largely remained intact. That may explain why Pawtucket posted a better record this April (13-10) as opposed to last April (9-13).
ŌĆ£I think these guys know each other and are comfortable in their roles,ŌĆØ said Beyeler. ŌĆ£The only thing is that weŌĆÖd like to be home more [the PawSox have played 15 of their first 24 games on the road] so we can work on some things. Defensively there are some things like holding runners and throwing to bases that we need to get better at, but itŌĆÖs tough when you canŌĆÖt get on the field and work on things.ŌĆØ


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Alan Pelz-Sharpe
Research Director, Social Business
Alan Pelz-Sharpe is the Research Director for Social Business at 451 Research. Alan has overall responsibility for the coverage of Social Business technology and trends, including social/collaboration, compliance and legal, marketing and sales automation and integration. Alan's own primary area of focus is on the emergence of next generation collaborative business applications that leverage the power of the crowd and cloud.
Alan has over 25 years of experience in the IT industry, working with a wide variety of end-user organisations and suppliers around the world. Alan was formerly a Partner at The Real Story Group, ECM Consulting Director at Indian Services firm Wipro, and VP for North America at industry analyst firm Ovum. He is regularly quoted in the press including the Wall Street Journal and The Guardian and has appeared on the BBC, CNBC, ABC as an expert guest.
Reports by this Analyst
MIS Impact Report - June, 2015
'If you can't beat them, join them,' is a good motto, and for Redbooth that means bringing social collaboration to the world of unified communications. Redbooth could potentially tap into a rich seam of opportunity providing modern and refreshed upsell opportunities to incumbent players.
MIS Impact Report - June, 2015
In its most significant move to date, post-IPO Box has entered a strategic partnership with IBM to build cloud-based collaboration and work applications. This is potentially transformational for Box. It goes beyond a simple reseller or basic integration announcement and states that the two firms will jointly develop applications for specific industry verticals.
MIS Impact Report - June, 2015
Whether Oracle was late to the cloud or not, 2015 is the year it's going big, and it is seeing some impressive early success. The company has thrown its full weight behind not just developing a credible cloud story, but in some areas, challenging for pole position.
MIS Spotlight - June, 2015
Enterprise file sync and share is maturing and the future landscape and current challenges are becoming much clearer than just a year ago. Simply sharing files and collaborating at the business level, separate from core business applications, may become a permanent fixture in the IT landscape.
MIS Impact Report - June, 2015
Enterprise content management stalwart EMC Documentum has been around since the earliest days of ECM and has long seemed to be an awkward fit within EMC. Yet it recently made its biggest shift in many years when it hooked up with Pivotal to rethink the ECM platform.
MIS Impact Report - June, 2015
The company continues its metamorphosis from a traditional ECM vendor into an enterprise-class BPM application-development platform complete with rich content management, extended collaboration and execution analytics.
MIS Impact Report - May, 2015
The Canadian company is yet another 'secure collaboration' vendor coming to market - with the rationale that it is the most secure option to date, taking advantage of Bitcoin-like security methods.
MIS Spotlight - May, 2015
Some buyers are now asking for cloud software code to be placed in escrow, a process historically restricted to on-premises systems. We examine the value of escrowing cloud-application code.
MIS Impact Report - May, 2015
The enterprise collaboration vendor launched with huge potential and solid backing some years ago – it's now time for it to truly take things to the next level. We look at what the prospects are for Igloo in a fast-growing but increasingly competitive market.
MIS Impact Report - May, 2015
The cannabis industry has long been a clandestine one, but as states in the US and countries around the world legalize or decriminalize its use, big money is moving in. Duby is a social media/networking service dedicated to cannabis users; it's still early for the startup, but its business model and approach contain lessons for marketers far beyond this industry.
MIS Impact Report - May, 2015
The company has been around for a few years now, and is proving to be quite popular as an enterprise collaboration/intranet alternative. It recently raised a new round of funding to continue its expansion plans in the US.
MIS Spotlight - May, 2015
The social business applications market will increase by over 2.5x between 2014 and 2019, according to Market Monitor: Social Business, a new market sizing and forecasting service from 451 Research.
MIS Impact Report - May, 2015
Slack is more than a social messaging service – it is at least three stories told at once. First, it is yet another enterprise social vendor in a crowded market; second, it is a ballsy David gearing up to take on Goliath(s); third, it's actually pretty good.
MIS Impact Report - April, 2015
As it prepares to potentially go its own way, Interact-Intranet is gearing up for further US expansion. Though not particularly well-known in the tech sector, the company has been growing steadily over the past couple of years and has a loyal following.
MIS Impact Report - April, 2015
In an era of heightened interest in control and governance issues, ownCloud thinks it has the answer to file sync and share's viral enterprise growth. We take a look at the company and its prospects of profiting from a heightened need to gain control of corporate files.
MIS Impact Report - April, 2015
On the surface, the player is yet another collaboration vendor, but Samepage's contextual approach is subtly novel. The firm likely needs more funding to take things to the next level, and if marketed properly, may appeal to small and midsized distributed workforces.
MIS Impact Report - April, 2015
The UK-based collaboration darling is making major efforts to raise its profile and move to the next level. Huddle is now entering a critical phase as it hopes to transition from being essentially a startup to a bona fide long-term player.
TDM Deal Analysis - April, 2015
BlackBerry has been reinventing itself as a software firm since its mobile device business hit the skids. The pickup of WatchDox is an interesting move by the company, and one that may presage more consolidation in the file-sharing space.
MIS Impact Report - April, 2015
The company's eponymous product is now at a point where it can be considered v2.0, and the cyclical topic of an email successor is back on the agenda, driven in large part by investor interest in heavily funded and functionally similar competitor Slack.
MIS Spotlight - April, 2015
Probably the last thing the world of business and IT needs right now is another acronym; then again, it needs another end-user-computing concern to add to the list even less. End-user computing applications are any technology applications running in the enterprise that are built by nonprogramming experts or are unsanctioned. Think of it as 'do-it-yourself shadow IT.'
MIS Impact Report - April, 2015
The Swiss vendor reckons that the white space between legal compliance and business imperatives gives organizations a 'blind spot' that is detrimental to the top line. Qumram seeks to shift from being a Web-archiving solution to providing customer insights in a compliant manner.
MIS Spotlight - March, 2015
IT, business and procurement teams must work together to acquire the right technology, at the right time and the right price, to meet the overall business goals. Here we outline a collaborative end-to-end IT acquisition process that organizations can use to build better use cases, identify the best possible vendors, and finalize technology decisions with confidence.
TDM Deal Analysis - March, 2015
Lexmark's highly acquisitive Perceptive division has added Kofax to its ever-bulging portfolio. This is the most significant acquisition to date for the firm, doubling not only the size of its software business but also its M&A spending.
MIS Impact Report - March, 2015
Despite its prominence in global government departments, Microsoft was late to the game when it came to offering integrated offerings to meet public-sector needs. Now, in partnership with AvePoint, it hopes to close the gap on the earlier movers.
MIS Impact Report - March, 2015
Cloud file storage was supposed to solve the problem of accessing clunky on-premises file stores, but it has created its own problems, with users struggling to locate critical information stored in multiple and poorly organized locations. Cloudfind is an application that aims to fix that problem.
MIS Impact Report - March, 2015
The big money in digital is not in the customer experience, it is in transforming the underlying business processes and supply chain, and that is just what Capgemini is focusing all its efforts on doing in North America.
MIS Impact Report - February, 2015
Despite all the noise, Facebook is not quite ready to launch an 'At Work' version of its popular social network, but it is certainly working on it. Over the next six months, it will look at feedback and input from trial users and figure out where to take the product.
TDM Sector IQ - February, 2015
As more organizations take on the challenges of a dynamic supply chain, digital asset management is finally being pulled toward the mainstream. This could lead to more acquisitions in the category.
MIS Impact Report - February, 2015
The company's Enterprise Key Management gives customers the ability to store and manage their own encryption keys. Box is looking to increase its wallet share with security-conscious enterprises and those that need to maintain control of keys to meet strict compliance requirements.
MIS Impact Report - February, 2015
Kaybus has solid funding and an interesting take on the labeling and identification of information. For a startup, it has a surprisingly sophisticated technology set that may fit in the broader jigsaw puzzle of next-generation applications, as well as the current content chaos era.
TDM Post-Merger IQ - February, 2015
In December 2014, private equity firm Accel-KKR acquired two Web content management providers in less than a week. As it looks to combine them, perhaps the totality of its vision is greater than it first appeared.
MIS Impact Report - February, 2015
What if you could leave all your file stores where they are and provide secure mobile cloud-like access to their contents? That is Primadesk's pitch for Unifyle, an on-premises enterprise-grade cloudlike portal.
MIS Impact Report - February, 2015
After fielding customer complaints regarding performance, user experience and TCO, SAP has built the new version of its business applications suite on the HANA in-memory platform. It has also been redesigned using the SAP Fiori user experience as the design principle, in order to ensure a dynamic user experience, and also a 'run anywhere' philosophy.
MIS Impact Report - January, 2015
Better known for its SMB tax-related products, Intuit is making a decent play in the emerging business collaboration sector. QuickBase is not a new product, but has seen renewed growth and interest as business users jump on its ability to easily build small task-focused applications.
TDM Deal Analysis - January, 2015
OpenText has announced the acquisition of file and image viewing software vendor Informative Graphics for an undisclosed amount. The target developed Brava, a tool that allows users to annotate and read any files, including complex CAD and image files.
TDM Deal Analysis - December, 2014
Immediately following its acquisition of the remaining 80% of Ektron that it didn't already own, Accel-KKR has purchased another Web content management vendor, EPiServer, from private equity firm IK Investment Partners.
TDM Deal Analysis - December, 2014
Previously a family-founded and -run firm, Ektron is now fully owned by a buyout shop. It's a move that illustrates well the challenges of the Web content management sector. The price Accel-KKR paid is in line with other WCM deals over the past couple of years.
TDM Deal Analysis - December, 2014
OpenText has smartly added analytics to its large portfolio of information products with the acquisition of BI champion Actuate. While many of its prior deals have brought little more than a stream of maintenance revenue, this transaction has more strategic implications for the company.
MIS Spotlight - November, 2014
Based on the results of our recent in-depth survey, it's still early on for EFSS in the enterprise, but things are formulating, and some surprising trends are beginning to emerge.
MIS Impact Report - November, 2014
Jive Software has certainly had an eventful year with changes aplenty. Not only is the firm fine-tuning its product and go-to-market strategies, but it has also been making changes to the leadership team, including the appointment of a new president.


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A formatted document containing blank fields that users can fill in with data. With paper forms, it is usually necessary for someone to transfer the data from the paper to a computer database, where the results can then be statistically analyzed. Some OCR systems can do this automatically, but they're generally limited to forms containing just check boxes. They can't handle handwritten text.
Electronic forms solve this problem by entirely skipping the paper stage. Instead, the form appears on the user's display screen and the user fills it in by selecting options with a pointing device or typing in text from the computer keyboard. The data is then sent directly to a forms processing application, which enters the information into a database.
Electronic forms are especially common on the World Wide Web because the HTML language has built-in codes for displaying form elements such as text fields and check boxes. Typically, the data entered into a Web-based form is processed by a CGI program.
From secure messaging to document editing, our top free must-have apps have been rated, reviewed and named the best free Android apps of 2015. Read More »The Five Generations of Computers
Learn about each of the five generations of computers and major technology developments that have led to the current devices that we use today. Read More »Cloud Computing Market Leaders, 2015
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From wacky alarm clocks to lecture hall tools and after class entertainment, these Android apps are a good fit for a student's life and budget. Read More »Network Fundamentals Study Guide
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Mohamed Soliman
|Mohamed Soliman
|محمد سليمان
21 July 1991
|Cairo, Egypt
|Alma mater
|Egypt Aviation Academy (B.S.)
|policy commentator
Internet Activist
Political strategist
|Known for
|Al-Midan student Group founder and leader
Political party
|Dostour Party ,Al-Midan Student Group
|Dr. Nabil Abd Elfatah (uncle)
Mohamed Soliman (Arabic: محمد سليمان) is an Egyptian Student Leader and political commentator and activist known for his criticism of the Mubarak and morsi regimes, his activity during the 2011 Egyptian revolution and leading the Liberal Students to win the Student unions elections in 2013 against the Muslim Brotherhood students.
Mohamed Soliman was born to a middle-class family on 21 July 1991 in Cairo.Mohamed holds a Bachelor's Degree in Construction and management from the Egyptian Aviation Academy.
Early activism[edit]
He was a protester from the Egyptian opposition movement Kefayaat the age of 15 . then, he joined the National Association for Change, and worked on collecting petitions calling for reforming the political system in Egypt.
2011 Egyptian revolution[edit]
he was active during the 2011 Egyptian revolution and its aftermath.
Dostour Party[edit]
Mohamed was a founding member of Dostour Party .he Served as a high Board member representing Youth. he also managed the foreign relations committee for a year.[1] [2] he was elected as the rapporteur of the political bureau of the Party on June 2014.
Al-Midan Student group[edit]
when AlDostour's party first started, he was elected as the President of AlDostour's Party Student Office then started founding Al-Midan clubs " existing in 20 public and private universities" . Mohamed oversaw Al-Midan and wide range coalition of liberal students campaign in the 2013 Student union elections against the Muslim Brotherhood students. Al-midan became majority in most of the Student unions . During his two-year leadership in Almidan Student group, Mohamed has voiced his opposition against decisions and statements made by the party's political committee and has identified himself with significant statements that reflect the opinions of the students (who are the largest supporters of the party) rather than the party's leaders.[3] Mohamed criticized and attacked AlMidan Affiliate Egypt SU president Mohamed Badran, when badran supported the brutality against the Muslim Brotherhood students.[4]
US-Middle East youth Network[edit]
Mohamed is a campus leader at the US-Middle East Youth Network, which is a platform aims to enrich the debate and exchange of views between American and middle eastern youth about the ongoing political situations.[5]
critic of President Mohamed Morsi[edit]
Mohamed was one of the architects for the 2012 Egyptian protests, to demonstrate against the former president Mohamed Morsi after issuing his constitutional decree.
mohamed soliman as a policy commentator[edit]
Mohamed Political Usually writes on Egypt & Middle East Politics in many prominent English and Arabic publications.
- List of soliman's Articles in Al-Masry Al-Youm
- List of soliman's Articles in Al Tahrir (newspaper)
- US military aid to Egypt: For whose sake?, Daily News Egypt, 3 November 2013
- JUNE 30TH: WHAT WENT WRONG? , US-ME youth Network, 5 December 2013
- Sisi's men: anticipating the coming regime, openDemocracy, 19 December 2013
- Dear Europeans, this is what happens in Egypt, Eutopia magazine, 13 June 2014
- Egyptian Assassinations and Islamist Escalation, The Washington Institute, 2 July 2015
See also[edit]
- ^ soliman, Mohamed (3 November 2013). "Student Corner: US military aid to Egypt: For whose sake?". http://www.dailynewsegypt.com. Retrieved January 13, 2014.
- ^ Lynch, Sarah (3 October 2013). "Egyptians on all sides skeptical of aid cut". http://www.usatoday.com. Retrieved January 2, 2014.
- ^ AbdAllah, AbdelHalim (25 November 2013). "Head of Egypt's Student Union under fire". http://www.dailynewsegypt.com. Retrieved January 2, 2014.
- ^ AbdAllah, AbdelHalim (25 November 2013). "Head of Egypt's Student Union under fire". http://www.dailynewsegypt.com. Retrieved January 2, 2014.
- ^ , (September 2013). "http://www.usmeyouthnetwork.org/campus-leaders.html". http://www.usmeyouthnetwork.org/. Retrieved January 2, 2014.


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Position Overview As Technical Services Analyst you will provide exceptional business-to-business technical services to world-class research organizations from the academic, government, healthcare, and pharma sectors ? those on the cutting edge of scientific innovation. Your6/6/2015 San Francisco, CA Save This Job
Tracking Code 2012079 Job Description PatientKeeper ? a leading provider of healthcare applications for physicians ? is now part of HCA, the largest provider of healthcare services in the U.S. With growth come new opportunities, so we are seeking Systems Performance Analyst to6/5/2015 Waltham, MA Save This Job
Location: Portland, OR, United States ABOUT JIVE SOFTWARE Jive Software is the leading provider of modern communication and collaboration solutions for business. Our products empower people and organizations to work better together, using technology that adapts to their way ?7/1/2015 Portland, OR Save This Job
Overview: Drives the transition from business requirements to functional requirements for the development of new software applications or enhancements to existing systems. Represents Product as member of Agile development team. Consults with users to identify current business6/15/2015 Austin, TX Save This Job
The Security and Risk team at HubSpot is looking to add an IT Security Analyst to the team to be part of the next generation risk management program. HubSpot's Security team is responsible for the HubSpot's comprehensive security and risk5/27/2015 Cambridge, MA Save This Job
Senior Business Systems Analyst Enterprise Applications6/16/2015 San Francisco, CA Save This Job
As an Analyst on the APM team, you will be responsible for working with other teams to determine what metrics should be gathered from a variety of applications. Additionally, you will write automated functional tests that will be used to perform regressio5/14/2015 New York, NY Save This Job
Quantcast is seeking a Campaign Optimization Analyst for our San Francisco office to ensure successful delivery of all display advertising campaign goals in conjunction with the Client Strategy and Sales teams. This is an analysis and client sup6/24/2015 San Francisco, CA Save This Job
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Integral Ad Science is the leading global media valuation company in the ad tech space. Integral provides buyers and sellers of digital media with data that is actionable in real time, to quantify the quality of every online ad event. We operate at a scale that is matched by very7/3/2015 New York, NY Save This Job
Tracking Code 1971 Job Description This is an exciting opportunity to build and maintain our current and future HR systems and operations. The HRIS Analyst plays a key role on the HR Operations team to provide analytic and systems support and maintain and enhance HR Operations5/19/2015 Redwood City, CA Save This Job
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Associate Salesforce Systems Analyst Company Overview:Velocify is one of the fastest growing software-as-a-service companies in the country, providing the market-leading solution for intelligent sales automation and cloud-based telephony. Velocifyâs software is designed for6/24/2015 El Segundo, CA Save This Job
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June 17, 2014
From the equipment you spec and maintain, to the fuel you buy, to driver training and incentives, you'll find tips for nearly any type of fleet.
February 6, 2014
Horton introduces the Modulator LCV40 Fully Variable Fan Drive and WindMaster Plastic LS11 Fan. These products will be available to the market in the spring of 2014. Compact and lightweight, Modulator LCV40 and WindMaster LS11 provide improved fuel economy.
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Mark Betner from CITGO, will answer your questions
The expert, Rence Oliphant from Hendrickson, will answer your questions
Timken Adds A Wheel End Parts Line
Eaton Expands Flex Reman Transmission Lineup
ARI Adds Custom Dashboards to Fleet Management System
TruckTech+ Provides Diagnostics to Fleets and Dealers


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Fashion Brand Names
Our intelligent name generators help you come up with creative name ideas. We also make sure that the domain name is available.
To save time, hold a naming contest to engage our community.
I need name ideas for (a):
Name Contest by soulglo
One word, maximum 7-8 letters, 2-3 syllables is fine - prefer it to be a completely made up word that kind of sounds healthy and active but sensible and quality at the same time.
Website provides exercise programs, products & videos for sale
Audience is men/women 30+ looking to get into shape at home
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Dine on fresh, flavorful Mexican food from this counter-service restaurant. The menu reflects California's rich heritage of Californian and Mexican flavors!
Annual Passport discount available at Cocina Cucamonga - 10% off (15% off with Premium Passport).
Choice of one beer or sangria.
Good sized burrito for the price. It comes with beans and rice too.
Caesar salad is pretty good. But get the dressing on the side. They really drench it in dressing.
Great fajita salad but watch out for the refried beans at the bottom.
Great food! Get the kids meal to save $$$.
Not that great of food here. Was bland and the tortillas weren't even cooked. They put wayyyyy too much beans in the burrito and not enough of the meat!!
The Carne Asada plate is tasty!
Tacos meh. Dos Equis Amber and Tecate if the line is too long at the beer cart.
Terrible Mexican food. Eat anywhere else. Go to the Pacific Wharf Cafe.
Spicy! (Which is good). Enjoyed the Monterrey Tacos.
あのね、日本の方、頭の上にも気をつけてね。鳥が爆弾落とすかも( ´ ▽ ` )ノ
def split an entree to cut cost. they're big enough to sit for awhile.
Chicken burrito is really good! Big food portions, reasonably priced.
Seasons pass? It's Annual Pass! And yes, they get discounts.
This is one of the best places to eat in all of Disneyland! Really great food - love the ck caesar and half chicken!
DVC gets you a discount here too!
A band comes out to deck periodically and plays live music
10% off with Disney Visa
Beer here!!!! Dos Equis Amber and Tecate!
Duelce de Leche Cheesecake...
Eat the carne asada, and grab a red trolley beer. Great combo!!
Rice is all messed up. Dry and spicy......
You've never heard the Mickey Mouse March until you hear it done by the Mariachi band here!!
Get the Carne Asada and Chicken Tamale plate. SO good!
The meat seems a little spicier than at Rancho inside D'land. My lips can still feel a little burn. I would eat here again.
Their green salsa is BOMB! dip your tortilla in it! Don't buy water ask for cups of ice water at the window... Save a few bucks :)
The beef tacos here taste like they have dirt in them. Worst meal I've had at this park ever!
This Mexican food is more like Gringocan food.
There's heaters in the seating area (:
The Carne asada sucks...but the tamales are yummy
Avoid! The tortillas were cold soggy dough in a bag :-(
better than rancho they have tamales here! and its a nice place right next to the pier
Disneyland serves the exact same food @ Rancho del Zocalo near Big Thunder. Gasp.
The mexican restaurant in Disneyland serves better food.
Hangs down the best food in disneyland and get a lot for your money unlike other places here.
Food is typical Mexican, what's cool about it is the mariachi band that plays around the seating area- they're really good!
Season pass holders get a discount.


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