text:
Direct-To-Consumer Genetic Tests:
Misleading Test Results Are Further Complicated by Deceptive Marketing and Other Questionable Practices
GAO-10-847T: Published: Jul 22, 2010. Publicly Released: Jul 22, 2010.
Additional Materials:
- Highlights Page:
- Full Report:
- Accessible Text:
(202) 512-9505
Office of Public Affairs
(202) 512-4800
In 2006, GAO investigated companies selling direct-to-consumer (DTC) genetic tests and testified that these companies made medically unproven disease predictions. Although new companies have since been touted as being more reputable--Time named one company's test 2008's "invention of the year"--experts remain concerned that the test results mislead consumers. GAO was asked to investigate DTC genetic tests currently on the market and the advertising methods used to sell these tests. GAO purchased 10 tests each from four companies, for $299 to $999 per test. GAO then selected five donors and sent two DNA samples from each donor to each company: one using factual information about the donor and one using fictitious information, such as incorrect age and race or ethnicity. After comparing risk predictions that the donors received for 15 diseases, GAO made undercover calls to the companies seeking health advice. GAO did not conduct a scientific study but instead documented observations that could be made by any consumer. To assess whether the tests provided any medically useful information, GAO consulted with genetics experts. GAO also interviewed representatives from each company. To investigate advertising methods, GAO made undercover contact with 15 DTC companies, including the 4 tested, and asked about supplement sales, test reliability, and privacy policies. GAO again consulted with experts about the veracity of the claims.
GAO's fictitious consumers received test results that are misleading and of little or no practical use. For example, GAO's donors often received disease risk predictions that varied across the four companies, indicating that identical DNA samples yield contradictory results. One donor was told that he was at below-average, average, and above-average risk for prostate cancer and hypertension. GAO's donors also received DNA-based disease predictions that conflicted with their actual medical conditions--one donor who had a pacemaker implanted 13 years ago to treat an irregular heartbeat was told that he was at decreased risk for developing such a condition. Also, none of the companies could provide GAO's fictitious African American and Asian donors with complete test results, but did not explicitly disclose this limitation prior to purchase. Further, follow-up consultations offered by three of the companies failed to provide the expert advice that the companies promised. In post-test interviews with GAO, each of the companies claimed that its results were more accurate than the others'. Although the experts GAO spoke with believe that these tests show promise for the future, they agreed that consumers should not rely on any of the results at this time. As one expert said, "the fact that different companies, using the same samples, predict different directions of risk is telling and is important. It shows that we are nowhere near really being able to interpret [such tests]." GAO also found 10 egregious examples of deceptive marketing, including claims made by four companies that a consumer's DNA could be used to create personalized supplement to cure diseases. Two of these companies further stated that their supplements could "repair damaged DNA" or cure disease, even though experts confirmed there is no scientific basis for such claims. One company representative even fraudulently used endorsements from high-profile athletes to convince GAO's fictitious consumer to purchase such supplements. Two other companies asserted that they could predict in which sports children would excel based on DNA analysis, claims that an expert characterized as "complete garbage." Further, two companies told GAO's fictitious consumer that she could secretly test her fiance's DNA to "surprise" him with test results--though this practice is restricted in 33 states. Perhaps most disturbing, one company told a donor that an above average risk prediction for breast cancer meant she was "in the high risk of pretty much getting" the disease, a statement that experts found to be "horrifying" because it implies the test is diagnostic. To hear clips of undercover contacts, see http://www.gao.gov/products/GAO-10-847T. GAO has referred all the companies it investigated to the Food and Drug Administration and Federal Trade Commission for appropriate action.
Jun 29, 2015
Medicaid:Service Utilization Patterns for Beneficiaries in Managed CareGAO-15-481: Published: May 29, 2015. Publicly Released: Jun 29, 2015.
Jun 24, 2015
Medicaid Demonstrations:More Transparency and Accountability for Approved Spending Are NeededGAO-15-715T: Published: Jun 24, 2015. Publicly Released: Jun 24, 2015.
Jun 22, 2015
Defense Health Care:DOD Needs to Clarify Policies Related to Occupational and Environmental Health Surveillance and Monitor Risk Mitigation ActivitiesGAO-15-487: Published: May 22, 2015. Publicly Released: Jun 22, 2015.
Jun 11, 2015
Mental Health:Better Documentation Needed to Oversee Substance Abuse and Mental Health Services Administration GranteesGAO-15-405: Published: May 12, 2015. Publicly Released: Jun 11, 2015.
Jun 10, 2015
VA Health Care:Improvements Needed to the Monitoring of Antidepressant Use for Major Depressive Disorder and the Accuracy of Suicide DataGAO-15-648T: Published: Jun 10, 2015. Publicly Released: Jun 10, 2015.
Jun 2, 2015
Medicaid:CMS Could Take Additional Actions to Help Improve Provider and Beneficiary Fraud ControlsGAO-15-665T: Published: Jun 2, 2015. Publicly Released: Jun 2, 2015.
Jun 1, 2015
VA Health Care:Actions Needed to Improve Monitoring and Oversight of Non-VA and Contract CareGAO-15-654T: Published: Jun 1, 2015. Publicly Released: Jun 1, 2015.
Medicare Administrative Contractors:CMS Should Consider Whether Alternative Approaches Could Enhance Contractor PerformanceGAO-15-372: Published: Apr 30, 2015. Publicly Released: Jun 1, 2015.
Patient Protection and Affordable Care Act:Despite Some Delays, CMS Has Made Progress Implementing Programs to Limit Health Insurer RiskGAO-15-447: Published: Apr 30, 2015. Publicly Released: Jun 1, 2015.
Private Health Insurance:Premiums and Enrollment for New Nonprofit Health Insurance Issuers Varied Significantly in 2014GAO-15-304: Published: Apr 30, 2015. Publicly Released: Jun 1, 2015.
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|423 posts found
Diablo 3 hacks are not a Blizzard problem states Blizzard
General Discussion « Diablo 3
Originally posted by Uhwop
When I quit WoW I tested it. I changed my password to the one I used for this site.
My WoW account is now banned. (its been restored)
Keylogger? No. Virus? No. Bad practice? Yes.
If you dont want your account "hacked", dont be dumb.
Diablo 3 hacks are not a Blizzard problem states Blizzard
General Discussion « Diablo 3
Originally posted by Mephster
Keep what secure? Them or you?
Did their server security get breached or did yours?
If you buy a car and leave the keys out in the open, someone takes the keys and drives off with your car, is that the fault of the car maker or you?
Lets say someone registeres to this website. Lets say they use the same email address as in WoW. Lets also say they use the same password.
How can Blizzard protect against that?
They offer the authenticator. If you take it, you better have it require authentication every login attempt too. This is a free service they provide or if you want the physical token you can buy that. So they have, in fact, provided security.
Diablo 3: 6.3 Million and Rising
News & Features Discussion « General Discussion
Originally posted by Yuui
So you said the sales are built upon misinformation supported by factual evidence. Source?
You said Blizzard bought reviews and its supported by evidence. Source?
Its true that the same individuals that made the original Diablo (and the not entirely same people) that made Diable2 didn't make Diablo 3. Whats your point?
You then state that D3 is the target of gold sellers and hackers. What does Blizzard have to do with that? Thats like blaming Microsoft for being the biggest target of real hackers that actually ruin peoples lives and damage companies.
Your bulleted points in a previous post is severely lacking in any facts as well. Other than point 6 which is true for any succesful game (and is by no means a negative).
If you want to spout off using the words "facts" and "evidence" you need to be prepared to provide these facts and evidence or sources. If not, then you are no better than a troll.
Looking for a new gaming computer.
Hardware « General Discussion
If you need a new gaming computer and you are relatively lacking in knowledge about computers I suggest avoiding self-builds and private sellers.
Go with pre-built from a company. You may not get the absolute best bang for your buck, but having a tech-support number is highly useful for people that either cant (for whatever reason) deal with or dont want to deal with the issues on their own.
On a side note... I find myself reading threads that Quizzical posts in.
Let me explain Diablo 3
General Discussion « Diablo 3
Originally posted by Aori
Content additions will come in the forms of paid expansions. There wont be free content added. The current patching plan is to bring PvP into the game, bug fixes and balance. This can be read by following the dev posts on Diablo official forums.
Why I defend online only.
General Discussion « Diablo 3
I cant figure out why people think that the online only online all the time model is DRM. The DRM aspect of it is purely a bonus for them.
The all-online aspect is 100% related to money. They want everyone to have access to the RMAH or as it is known in other games, cash shop.
Shady or not, the game is released. The game has the AH. The game is all online. They will never make an offline version. They want the revenue.
Do I support the model? No. But I dont care since it doesn't bother me or get in the way of my play.
Let me explain Diablo 3
General Discussion « Diablo 3
Originally posted by colddog04
Thanks for highlighting a line I purposely put int there and seperate from the rest of the information.
Also, thanks for ignoring any sort of content of the posts and your continuation of trolling the thread.
LOL... Defending Blizzard DRM? But not Ubisoft?
General Discussion « Diablo 3
Originally posted by stayontarget
Few days? Not for a couple years. And in the event I do have to wait until the next day for a technician I can use my phone to connect. Even so, I am fortunate enough to play games for fun. No single game is all-important that I cannot switch to another game. Or, more likely, walk away from the computer and spend time with my kids or another hobby.
Not to say I wont support those that are negatively impacted by a DRM. But I also understand the need for DRMs. DRM is simply the company attempting to protect its own interests and revenue. So with that, I wont oppose a DRM for the sake that it is a DRM. That is just silliness.
3.6/10 user score with 2071 reviews on Metacritic
General Discussion « Diablo 3
Originally posted by TurkeyB
If you credit that review as a 100% worthless review, then you must, by default, credit the opposite reviews the same. Both provide an unreliable and unclear picture of what the game really is. Both provide a numerical score un-telling of the real story or relatable experience.
LOL... Defending Blizzard DRM? But not Ubisoft?
General Discussion « Diablo 3
I am 100% online all the time anyway. The DRM doesn't bother me.
3.6/10 user score with 2071 reviews on Metacritic
General Discussion « Diablo 3
Originally posted by zymurgeist
Actions do speak louder than words. People buying the game in droves is highly contrary to the vocal minority spewing hate on Metacritic.
I, personally, read between the lines when reading reviews. Professional reviews are worthless to me other than to tell me what the game is about. They've scored total bombs of games well and tend to over-sell anything that isnt just total crap. The most recent MW has great reveiwer scores, bad user scores, sold very well.
User scores cannot be taken at face value and the actual number provided is worthless. Read what is being said about whats bad and take that into account rather than what their opinion of the game is. The game not working day 1 pissed me off. But once I got into the game and started playing it, it was far better than a 3.6. Is the game a 9 or 10? Don't know. But so far I am getting a lot of what I expected and wanted.
Let me explain Diablo 3
General Discussion « Diablo 3
Originally posted by GrayGhost79
The defense that was presented and defended here is purely a technical one when it is such an integral part of many other aspects of the game.
RMAH: How does the RMAH work? It works by players using it. Blizzard takes a cut and boom, free money. How to exploit the free money? Make sure everyone has access to it. How do you do that? Give it to the people who don't care to coop as well. But they dont play online.... How to fix that? All online.
DRM: DRMs are purely anti-piracy, which is again business and not technical. Its to help prevent the game from being played without being paid for. This also allows more players access to the F2P micro-transaction store thats brilliantly disguised as the RMAH.
Anti-cheat: The MMO client-server setup has proven to be far more reliable in terms of anti-cheat than any other popular method. A strong perception of anti-cheat must also be provided given the IP's history of being riddled with cheats and hacks. More so than other titles.
Acheivements: Funny I'd list this here. But its a social grab. It gets people more involved into the game and groups into it. This needs to be shared and also needs a strong sense of legitimacy surrounding it. Again, better supported by all-online. This ties to the social-networking aspect of gaming that Blizzard has been migrating towards as well. But it isnt required since there are plenty of solo players that go acheivement/badge hunting.
Those are 4 reasons for the all-online single player experience. But most importantly. Money is the biggest reason. By making it all online they are better able to monetize the game and ensure profits.
Let me explain Diablo 3
General Discussion « Diablo 3
Originally posted by colddog04
It isn't them who are stubborn. They've all provided examples and methods to counter, argue or contest your points. You've done nothing but refute or as zymurgeist states, say "nuh-uh".
I'll spell out what they've said for you. Please use some for of actual counter-arguement or fact-based explanation rather than general denial, strawman or well-done trolling.
The all-online helps a better play experience by maintaining the same set of characters for both single-player and multi-player experiences. So there are not two-sets of characters.Having the same character with the ability to do both is too risky and everyone agrees.
The over-simplified term "mini server" in your client suggests that the overall same code or large portions of the same processes and logic on managing and running the game in every aspect would be duplicated on your client as well as on the server. This would give insight on the server vulnerabilities and increase risk of hacks being developed or exploits (which by definition are not hacks but rather advantages derived from unexpected results of existing game code). This overall same code, logic or processes being similiar would make programs to exploit or "hack" them online with Blizzard servers easier to create and test.
Providing client versions of game management and content will allow emulators to be more easily created and piracy to occur.
I know nothing of programming other than basic VBA excel macros.
The reasons for no single-player offline experiences is tied with many other aspects of the business decisions made and are only minorly supported by the technical aspects. The naming of a single technical aspect in which you've devoted an incredible amount of effort to dispute or refute is more of a benefit of the real reasons being dollars and cents to name two.
So please, enlighten us on how providing a copy of how the game is run to the client does not help or benefit in any way the development and testing of a program used to exploit, hack, alter, confuse or in any way "cheat" on the server-side multiplayer experience?
DOTA: Blizzard & Valve Settle DOTA Trademark Dust Up
News & Features Discussion « General Discussion
Oiy... You missed so much important context to much of what you said or just intentionally tried infusing as much spin as you could. Your post is just drooling of either Valve fanboyism or Blizzard haterism. Maybe both.
The reality is that neither company had strong footing to trademark the name for themselves. We don't know the terms of the settlement. The facts that are present are that Blizzard is changing the name of its own game and may use the name in a restricted sense. Beyond that is pointless to guess.
I read the entire proposal for the trademark, Blizzard's response and Valve's counter-response. I am not a lawyer myself. It doesn't really matter until it begins to get in the way of the players.
Mining in EVE - why has it gone neglected for so long?
Jita (General) « EVE Online
Adding some "flavor" and nice-to-haves to mining would be neat. Major changes to the mechanics arent required though. And it would be counter-productive to make mining harder.
The idea about mining vessels being weak isnt bad. It forces the requirement for protection which goes with the theme that EVE is a team game.
So there are pretty much 2 ways to put orbits into the game.
1: make everything rotate around the sun on a plane or disk and give the illusion of orbit but no real movement.
2: move things independently of eachother (all 1000's of belts, planets, gates and stations) with 100s of hours of work for very little gain (and likely making bookmarks and bookmarking system very difficult to use, broken or ineffectual)
I really dont see benefit to orbit unless they include warp collision and interstellar object gravity wells (natural interdictors) and go with the whole super high detail into space navigation. That isnt going to happen. EVE is a super hardcore game. But it is still a game so the mechanics have to cater to fun over realism. Balance between reality and fun is always difficult but if you add impacting realism to a game, it needs to add fun otherwise it only contributes to attrition and loss.
Diablo 3: Analyst Predicts 5M Sales
News & Features Discussion « General Discussion
Originally posted by DarkPony
They are different enough from eachother that I suspect there wont be much of a "war". Even so, a significant enough portion of those interested in both will pick up both rather than just one over the other.
But whatever competition may exist will only benefit us players more.
Diablo 3: Analyst Predicts 5M Sales
News & Features Discussion « General Discussion
From my experience with large corporations is that each product/franchise/IP/business has its own set of books. The $99 annual pass would be a co-branded sales strategy so funds would goto both products. Its a good way to determine if a product is profitable on its own or requires subsidy from other products.
World of Warcraft: Legal Battle Over Baby Murloc's Voice
News & Features Discussion « General Discussion
While working at Blizzard, Lewis says, she received an email requesting voices for "World of Warcraft" creatures...
Just funny to note that she can somehow claim that her work was used without permission by submitting it to an email request for such work. I hope she gets sh*t stomped in court and required to pay Blizzard legal fees. Frivolous lawsuits need to stop or be curbed.
Guild Wars 2: A New Breed of MMORPG?
News & Features Discussion « General Discussion
The problem with some of the games is that gear is all that matters. Any reality aside (as reality really just doesn't matter in games), gear in WoW and SWTOR are all that matters. Gear in GW1 didn't matter at all. Gear in UO barely mattered. A full set of GM crafted gear in UO was disadvantaged to a full set of invulnerable and vanquishing, but not so much that skill didn't play the bigger role.
I dont care if you are in a WW2 sherman vs the most modern prototype battle tank, if they are put into a game in the same field to fight, the sherman should be able to accomplish something or have an impacting purpose on the field. Now, that story can be totally different if the players arnt put into the same field but wander to the same field on thier own.
Even then, the leveling game and the end game are two different games. Once in the end game, the disparity between players shouldnt be prohibitively vast unless system exist to still allow fun for both players.
The problem only exists when gear > skill. Thats where complaints originate. Sure, sometimes gear is a huge factor, but whenever it is THE factor it is frustrating and generally looked down upon.
Blizzard Should Win Against Valve Over Dota 2
The Pub at MMORPG.COM « General Discussion
I start to read posts on the arguement of this issue and just have to stop.
There really isnt a point to respond to any individual post when there is SO MUCH IGNORANCE.
Get facts clear before opening your mouth on the issue.
Valve is attempting to trademark the name DOTA.
Blizzard is attempt to STOP Valve from obtaining the trademark
Blizzard has NOT stated anywhere directly or indirectly in any court filed or legal matter that they are trying ot obtain the trademark.
Blizzard even used the arguement that the DOTA name should belong to the community to stop Valve.
Please read the above line in green again.
Ok. So now the arguement should not be about Blizzard getting it or not. It should be about if Valve should have it vs nobody having it.
Does Valve really have more claim to the DOTA trademark than Blizzard, previous developers of DOTA and the community? No, I dont think so. I agree with Blizzard that the trademark should belong to the community.
And yes, the arguements listed include community ownership, which goes a long way in stopping Blizzard from obtaining the rights and trademark themselves. This, in addition ot the lack of trademark in this time does lead to the mark becoming public as it has gone unclaimed or defended in over 7 years.

subset: commoncrawl


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Tachyon is a ray-tracer application, rendering objects described in data files. The Tachyon program is located in the product samples directory: <install-dir>/composerxe/Samples/<locale>/C++/tachyon_compiler.tar.gz. By default we use balls.dat as the input file. Data files are stored in the directory tachyon/dat. Originally, Tachyon was an application with parallelism implemented in function pthread_create() with explicit threads: one thread does the rendering, and the other makes calculations.
Kit de desenvolvimento de software Intel® Cilk Plus
英特尔® 并行调试器扩展
Intel® Parallel Debugger Extension for Microsoft Visual Studio*
New Rules for Array Sections in Intel® Cilk™ Plus
This blog covers two important changes in the new specification to improve the language extension. One permits compilers to generate more efficient code. The other resolves a fundamental conflict that array sections brought up.
Visualize this! Intel Cilk Plus SDK
Welcome to Visualize this! the show where we talk about game development. I have an interesting lineup of guests for this year, and if you have guests you would like to hear from, send me note.
My guest today is Barry Tannenbaum Software Engineer and Cilk Developer at Intel. Barry and his team recently released the Cilk PLus SDK and he spoke with me on its value proposition to developers.


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PRLog - July 19, 2014 - ADELAIDE, Australia -- Flash Cab Australia released its new 2015 Toyota Tarago Flash Cab accessible vehicle 100% taxi compliant this month in Sydney proving to be a big hit with the taxi industry and the general public. Flash Cab's director John Cooper has been personally overlooking the release of the new 2015 Flash Cab in Sydney and couldn't be happier with the attention the new model has received.
Flash Cab Australia is at the forefront of accessible vehicle developments and has been for the last 22 years. Flash Cab Australia's director John Cooper has over 40 years experience in the motor trade and with 23 years experience in the disability field quoted "We have always been innovators".
Flash Cab Australia an Adelaide based company has recently moved their whole operation to Adelaide with wheelchair conversions applied locally. John Cooper commented that moving the operation to Adelaide was a strategic move resulting in an improved model with the first 2 year unlimited kilometer taxi warranty on conversions on offer in Australia. Wagga Radio Cabs have been successfully running 2 Flash Cab Caddy Maxi taxis & Horsham taken delivery of a Flash Cab Caddy Maxi with new orders coming in every day.
The new 2015 Flash Cab meets the new 2014/15 public transport standards, commonly referred to as the "Cube Standards" has many improvements on the old model.
The drive in this car is outstanding, smooth and quiet for all passengers and driver. Visibility for all passengers including wheelchair person is much improved, with the one piece panoramic side window. Another great feature is a simpler restraint system, non removable so they can't be stolen. Full size spare wheel internally stored, hidden storage spaces for the driver, built In stowage for baby capsule and non carpeted rear floor for easy cleaning. IMPROVED WATER SEALING OF REAR whisper quiet compartment, simpler rear seat folding and more passenger leg room.
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text: This amazing building is the Shell residence by Japanese Architect, Kotaro Ide of ARTechnic. The project concluded its works in 2008; the sculptural shell-like structure was built in the forest of Karuizawa, located in the Nagano, Japan. Its organic shape seems subtle within the forest, and the reinforced cement structure becomes one and harmonizes itself with the landscape. A clear distinction of the spaces [structure vs. nature] upgrades the quality of the residence as a shelter; the house will be sheltered from nature and utilize what nature can offer. The exterior of the "Shell†residence is wrapped in the shell-like concrete structure finished with a penetrative sealer for concretes, which contrasts with the green landscape. Deck wood is used on the patio, while a small amphitheater-like structure has been created in the center of the house around a full-grown tree. Large double glazed openings allow for uninterrupted views of the nature from within the house.


text:
A Stereoelectroencephalographic (SEEG) Study of Light-Induced Mesiotemporal Epileptic Seizures
Article first published online: 3 AUG 2005
DOI: 10.1111/j.1528-1157.1998.tb01296.x
Volume 39, Issue 10, pages 1098–1103, October 1998
Additional Information
How to Cite
Isnard, J., Guénot, M., Fischer, C., Mertens, P., Sindou, M. and Mauguière, F. (1998), A Stereoelectroencephalographic (SEEG) Study of Light-Induced Mesiotemporal Epileptic Seizures. Epilepsia, 39: 1098–1103. doi: 10.1111/j.1528-1157.1998.tb01296.x
Publication History
- Issue published online: 3 AUG 2005
- Article first published online: 3 AUG 2005
- Accepted March 18, 1998.
- Abstract
- References
- Cited By
- Light-induced seizures;
- Temporal lobe epilepsy;
- Epilepsy surgery
Summary: Purpose: This study explored the mechanism of light-induced complex partial seizures by using ictal intracerebral recordings in a patient with refractory epilepsy of the right temporal lobe.
Methods: Presurgical evaluation of this patient was realized by means of video-EEG recordings, WADA test, magnetic resonance imaging (MRI), F18-deoxyglucose and C11-flumazenil positron emission tomography (PET) interictal neuroimaging data, and stereoelectroencephalographic (SEEG) ictal recordings.
Results: SEEG investigations demonstrated the right mesiotemporal origin of all the patient's seizures. This result was confirmed by a successful right temporal lobectomy. Moreover, SEEG recordings revealed a frequent interictal spiking activity in the right occipital visual cortex that was undetectable on scalp recordings. However, the occipital cortex was not involved at the onset of mesiotemporal ictal discharges and was not hyperresponsive to focal electrical stimulation.
Conclusions: This study shows that, in spite of interictal occipital spiking, the photosensitivity of mesiotemporal seizures can be observed in both the absence of occipital cortex involvement during ictal discharges and demonstrable hyper-excitability of the occipital cortex to light or direct electrical stimulation.


text:
Fire at water sports centre
More than 40 firefighters are tackling a fire at a water sports centre in Rock in Cornwall.
More than 40 firefighters are tackling a fire at a water sports centre in Rock in Cornwall.
A fire at a water sports centre in Rock near Wadebridge is being treated as suspicious by police.
40 fire-fighters tackled the blaze which started shortly after 3am this morning.
Police have launched a joint investigation with the fire service. Investigators were on the scene this morning to try and establish the cause.
The building has been severely damaged. Thankfully there was no-one inside at the time otherwise we could have been dealing with an even more tragic outcome.
Although there may not have been many people around at that time in the morning we are hoping someone may have seen something that could assist with the investigation.
If you saw anything suspicious please get in touch.
The road was closed at the junction of Rock Road and Bodmin Lane until 7.30am.
Anyone who has any information is asked to call police on 101 quoting log 84 of 25/07/13 or Crimstoppers anonymously on 0800 555 111.
Dementia patients are being failed by health and social care services, say doctors in our region.
Fragrant, beautiful and more and more popular in soft drinks, this year's elderflower crop has been particularly good for our region.
It's not just visitors at Exmoor Zoo who've been tucking into ice lollies and cool drinks in the heat - check out these charming pictures


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How many times have you let an opportunity fall off your radar, or worse, completely missed an opportunity because you didn't take the time to ponder the possibilities with a contact? Don't write those off as lost opportunities so fast.
Attending Live Social Media Events – Which Events Are Right For You?
Social Media Policies and Compliance Software For Businesses
Make Your Blog Feel Like Home and Keep Visitors Coming Back
Marketing your blog to pull in traffic is only half the quest, once you get a visitor to your blog you need to make them feel welcome and at home. I can best relate this to entertaining guests in my home. Most women are fanatical about having their homes in perfect condition before inviting guests […]
4 Tips To Immediately Attract More Blog Comments
A Chick's Guide to Building Word-of-Mouth Referrals
For any business, there simply is no better form of advertising than word-of-mouth—whether it be a friend on Twitter or a co-worker at the office. A personal referral from someone whose opinions others trust and respect goes a long way. If you're a small business owner with a small or non-existent advertising and marketing budget, word-of-mouth referrals are your best friend.


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... but I couldn't resist. Plus I helped start this fad anyway.
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Cantora Records' Group
74.4K Plays / 65 Likes / 11 Comments
Directed by - SHIA LABEOUF From the Rumspringa EP on Cantora Records. Available on iTunes and at cantorarecords.com myspace.com/rumspringa cantorarecords.com+ More details
10.9K Plays / 52 Likes / 2 Comments
From the "What A Drag" digital package and 7" release on Cantora Records, 2010. Download "What a Drag", "Can't Stick 'Em", and Cale Park's Remix…+ More details
4,374 Plays / 51 Likes / 2 Comments
"Destrokk" From the Time to Pretend EP on Cantora Records. Purchase it here: www.cantorarecords.com/shop/releases/cds/mgmt-time-to-pretend-ep-re-mastered Directed by John Miserendino www.whoismgmt.com www.johnmiserendino.com www.cantorarecords.com+ More details
Francis and the Lights // LIME Live03:01
13.4K Plays / 37 Likes / 3 Comments
Francis and the Lights perform LIME at the Bowery Ballroom NYC. Make sure to watch til the end. Get the LIME/WYN 7" Vinyl and CD at http://cantorarecords.com/shop/releases/lps/francis-and-the-lights-lime-wyn-7 Directed…+ More details
Rumspringa // "Shake 'Em Loose Tonight" Acoustic Version03:07
2,043 Plays / 25 Likes / 1 Comment
Cantora Creative acoustic session of "Shake 'Em Loose Tonight," from the Rumspringa EP. www.myspace.com/rumspringa www.cantorarecords.com+ More details
2,489 Plays / 20 Likes / 0 Comments
From the Time to Pretend EP on Cantora Records. Purchase it here: www.cantorarecords.com/shop/releases/cds/mgmt-time-to-pretend-ep-re-mastered Directed by Max Goldblatt www.whoismgmt.com www.planrpictures.com/ www.cantorarecords.com+ More details
5,142 Plays / 20 Likes / 0 Comments
"Doomed" from Violen's self-titled EP, out now on Cantora Records. Directed by Mateo Ramirez www.myspace.com/violensmusic www.cantorarecords.com+ More details
1,426 Plays / 11 Likes / 1 Comment
"Goldmine" from the Rumspringa EP on Cantora Records http://www.myspace.com/rumspringa www.evanromoff.com www.cantorarecords+ More details
RUMSPRINGA // "Catfish Blues" Live @ The Echoplex05:57
1,376 Plays / 9 Likes / 2 Comments
Cantora Creative covers Rumspringa live at The Echoplex, June 2nd 2008 - Night One of The June Residency. Big time thanks to Evan Romoff and Lori Levine. www.myspace.com/rumspringa www.cantorarecords.com+ More details
Francis and the Lights - LIME/WYN 7" Vinyl01:11
1,318 Plays / 9 Likes / 1 Comment
Get Francis and the Lights' LIME/WYN 7" at http://cantorarecords.com/shop/releases/lps/francis-and-the-lights-lime-wyn-7 francisandthelights.com cantorarecords.com+ More details
Savoir Adore // "MERP" $99 Video03:05
1,056 Plays / 7 Likes / 1 Comment
Directed by Matthew Semel for "$99 Video" on the Next New Network. "$99 Music Videos is an independent music network dedicated to merging low-fi, cutting-edge videos with the best…+ More details
Savoir Adore // "Sarah's Secret" Studio Session03:08
2,117 Plays / 7 Likes / 1 Comment
Cantora Creative studio session of "Sarah's Secret," off of Savoir Adore's In The Wooded Forest in stores everywhere and on itunes now. www.cantorarecords.com/shop/releases/cds/savoir-adore-in-the-wooded-forest-lp www.myspace.com/savoiradore www.cantorarecords.com+ More details
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Posted on Wednesday, October 9, 2013 at 5:07 pm
Community R-VI Lady Trojans pitcher Dani Jackson gets ready to make a play during their home game against the Cairo Lady Bearcats on Thursday, October 3. (No game information made available at press time.)
What do you think about the alleged "hacking" incident involving the St. Louis Cardinals?
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36 year old woman | San Antonio, TX, USA | Seeking men 34-45 within 50 miles
That special person must have a sense of humor but at the same time know when to be serious. He must be honest, caring, and most of all loyal. I do have two kids that are my world and priority, so it is just as important that he understand my unique situation. With that being said, please don't think I don't have enough love to spread around. I am very good at juggling many plates at one time and fully capable at maintain a healthy relationship and taking care of my kids to the fullest. Family is another factor that is very important to me. I have a huge extended family that gets together often and would like someone who will be comfortable with all of the commotion! It's always good food and company along with lots of laughs. I was born and raised here in San Antonio but I have been gone for the past 5 years so it's as if I am new to the city. I would love someone who is interested in both going out for a fun filled evening and also ok with stay home and enjoying quality time together. I do enjoy working out on a regular basis and would like someone who can enjoy that with me. I am just a good hearted person with lots to offer, for the right person of course! I am not into playing games and take my relationships very serious. Most of all I want someone I can be myself with and have a good time with. If you have more specific questions you would like to ask I am open to answering anything so just drop me a line.
Camping , Coffee and conversation , Cooking , Dining out , Movies/Videos , Music and concerts , Nightclubs/Dancing , Performing arts , Playing sports , Religion/Spiritual , Travel/Sightseeing , Watching sports
Aerobics, Baseball, Basketball, Bowling, Cycling, Dancing, Running, Soccer, Tennis / Racquet sports, VolleyBall, Walking / Hiking, Weights / Machines, Yoga
I exercise 3-4 times per week.
I have Horses
I like Cats, Dogs, Fish
Middle of the Road
Texas State University–San Marcos, San Marcos, TX
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'8" (172cms)
|5'10" (177cms) to 7'0" (213cms)
|Body type:
|Athletic and toned
|About average, Athletic and toned
|Black, Blue, Brown, Grey, Green, Hazel
|Dark brown
|Auburn / Red, Black, Light brown, Dark brown, Blonde, Salt and pepper, Dark blonde, Bald
|No Way
|No Way
|Social Drinker
|Social Drinker, Regularly
|Medical / Dental / Veterinary / Fitness
|No preference
|I'll tell you later
|No preference
|No preference
|Have kids:
|Yes, and they live at home (2)
|No preference
|Wants kids:
|No, but it's OK if my partner has kids
|No preference
|Latino / Hispanic
|No preference
|Christian / Catholic
|No preference
|English, French, Spanish
|Bachelors degree
|Some college


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Are you Hilda H Brown?Claim your profile
Publications (7)24.37 Total impact
- SourceAvailable from: PubMed Central
Article: Analysis of Mutant SOD1 Electrophoretic Mobility by Blue Native Gel Electrophoresis; Evidence for Soluble Multimeric Assemblies[Show abstract] [Hide abstract]
ABSTRACT: Mutations in superoxide dismutase 1 (SOD1) cause familial forms of amyotrophic lateral sclerosis (fALS). Disease causing mutations have diverse consequences on the activity and half-life of the protein, ranging from complete inactivity and short half-life to full activity and long-half-life. Uniformly, disease causing mutations induce the protein to misfold and aggregate and such aggregation tendencies are readily visualized by over-expression of the proteins in cultured cells. In the present study we have investigated the potential of using immunoblotting of proteins separated by Blue-Native gel electrophoresis (BNGE) as a means to identify soluble multimeric forms of mutant protein. We find that over-expressed wild-type human SOD1 (hSOD1) is generally not prone to form soluble high molecular weight entities that can be separated by BNGE. For ALS mutant SOD1, we observe that for all mutants examined (A4V, G37R, G85R, G93A, and L126Z), immunoblots of BN-gels separating protein solubilized by digitonin demonstrated varied amounts of high molecular weight immunoreactive entities. These entities lacked reactivity to ubiquitin and were partially dissociated by reducing agents. With the exception of the G93A mutant, these entities were not reactive to the C4F6 conformational antibody. Collectively, these data demonstrate that BNGE can be used to assess the formation of soluble multimeric assemblies of mutant SOD1.PLoS ONE 08/2014; 9(8):e104583. DOI:10.1371/journal.pone.0104583 · 3.53 Impact Factor
Article: Metal-deficient aggregates and diminished copper found in cells expressing SOD1 mutations that cause ALS[Show abstract] [Hide abstract]
ABSTRACT: Disruptions in metal ion homeostasis have been described in association with amyotrophic lateral sclerosis (ALS) for a number of years but the precise mechanism of involvement is poorly understood. Metal ions are especially important to familial ALS cases caused by mutations in the metalloenzyme copper-zinc superoxide dismutase (SOD1). To investigate the role of metals in aggregation of mutant SOD1, we have examined the localization of metal ions in a cell culture model of overexpression. Chinese hamster ovary cells (CHO-K1) were transfected to overexpress SOD1 fused to yellow fluorescent protein (YFP) to readily identify the transfected cells and the intracellular aggregates that develop in the cells expressing mutant or wild-type (WT) SOD1. The concentration and distribution of iron, copper, and zinc were determined for four SOD1 mutants (A4V, G37R, H80R, and D125H) as well as a WT SOD1 using X-ray fluorescence microscopy (XFM). Results demonstrated that the SOD1 aggregates were metal-deficient within the cells, which is consistent with recent in vitro studies. In addition, all SOD1 mutants showed significantly decreased copper content compared to the WT SOD1 cells, regardless of the mutant's ability to bind copper. These results suggest that SOD1 overexpression creates an unmet demand on the cell for copper. This is particularly true for the SOD1 mutants where copper delivery may also be impaired. Hence, the SOD1 mutants are less stable than WT SOD1 and if copper is limited, aggregate formation of the metal-deficient, mutant SOD1 protein occurs.Frontiers in Aging Neuroscience 06/2014; 6:110. DOI:10.3389/fnagi.2014.00110 · 2.84 Impact Factor
Article: Experimental Mutagenesis of Huntingtin to Map Cleavage Sites: Different Outcomes in Cell and Mouse Models.[Show abstract] [Hide abstract]
ABSTRACT: Background: N-terminal cleavage products of mutant huntingtin (htt) generate pathologic neuronal inclusion bodies. The precise length of the htt fragment, termed Cp-A/1, that produces HD pathologic inclusions is unknown. Objective: We sought to elucidate the protein sequence elements within the N-terminus of htt that mediate its proteolysis based on a model in which engineered htt fragments terminating at residue 171 are cleaved to produce Cp-A/1 fragments. Methods: We expressed htt N171 cDNAs harboring a series of experimental mutations in the presumptive cleavage site that generates Cp-A/1 in cells to identify cleavage resistant mutants of htt N171. One of these constructs was expressed in mice, followed by analysis using immunoblots of brain extracts and immunohistochemistry of transgenic mouse brain tissues. Results: Using the HEK293 cell model, mutagenesis studies mapped the cleavage site in htt N171 to sequences between residues 105-114. Mutation of 8 positively charged residues (H, K, R) located between residues 88 and 114 to alanine to neutralize the charge also blocked the generation of Cp-A/1 like fragments. Transgenic mice expressing this latter construct, termed N171-82Q-N8, developed phenotypes similar to previously characterized N171-82Q transgenic mice, including rotarod deficiency, intranuclear inclusions, and premature death. Surprisingly, the N171-82Q-N8 protein was efficiently cleaved in vivo to produce Cp-A/1 fragments that accumulated as insoluble inclusions. Conclusion: Mutagenesis of htt to identify critical amino acids that direct its cleavage predicted a role for charged residues in the sequence flanking the presumptive cleavage site. However, the role for these residues could not be confirmed in vivo. The basis for the discrepancy between predicted outcomes in HEK293 cells and the mouse models remain unresolved, but the data provide another validation of the hypothesis that Cp-A/1 fragments of mutant htt can induce HD-like phenotypes.
Article: Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-Terminal Fragments in an HEK293 Cell Model[Show abstract] [Hide abstract]
ABSTRACT: N-terminal fragments of mutant huntingtin (htt) that terminate between residues 90-115, termed cleavage product A or 1 (cp-A/1), form intracellular and intranuclear inclusion bodies in the brains of patients with Huntington's disease (HD). These fragments appear to be proteolytic products of the full-length protein. Here, we use an HEK293 cell culture model to investigate huntingtin proteolytic processing; previous studies of these cells have demonstrated cleavage of htt to cp-A/1 like htt fragments. Recombinant N-terminal htt fragments, terminating at residue 171 (also referred to as cp-B/2 like), were efficiently cleaved to produce cp-A/1 whereas fragments representing endogenous caspase, calpain, and metalloproteinase cleavage products, terminating between residues 400-600, were inefficiently cleaved. Using cysteine-labeling techniques and antibody binding mapping, we localized the C-terminus of the cp-A/1 fragments produced by HEK293 cells to sequences minimally limited by cysteine 105 and an antibody epitope composed of residues 115-124. A combination of genetic and pharmacologic approaches to inhibit potential proteases, including γ-secretase and calpain, proved ineffective in preventing production of cp-A/1. Our findings indicate that HEK293 cells express a protease that is capable of efficiently cleaving cp-B/2 like fragments of htt with normal or expanded glutamine repeats. For reasons that remain unclear, this protease cleaves longer htt fragments, with normal or expanded glutamine expansions, much less efficiently. The protease in HEK293 cells that is capable of generating a cp-A/1 like htt fragment may be a novel protease with a high preference for a cp-B/2-like htt fragment as substrate.PLoS ONE 12/2012; 7(12):e50750. DOI:10.1371/journal.pone.0050750 · 3.53 Impact Factor
Article: Role of Disulfide Cross-Linking of Mutant SOD1 in the Formation of Inclusion-Body-Like Structures[Show abstract] [Hide abstract]
ABSTRACT: Pathologic aggregates of superoxide dismutase 1 (SOD1) harboring mutations linked to familial amyotrophic lateral sclerosis (fALS) have been shown to contain aberrant intermolecular disulfide cross-links. In prior studies, we observed that intermolecular bonding was not necessary in the formation of detergent- insoluble SOD1 complexes by mutant SOD1, but we were unable to assess whether this type of bonding may be important for pathologic inclusion formation. In the present study, we visually assess the formation of large inclusions by fusing mutant SOD1 to yellow fluorescent protein (YFP). Experimental constructs possessing mutations at all cysteine residues in SOD1 (sites 6, 57, 111, and 146 to F,S,Y,R or G,S,Y,R, respectively) were shown to maintain a high propensity of inclusion formation despite the inability to form disulfide cross-links. Interestingly, although aggregates form when all cysteines were mutated, double mutants of the ALS mutation C6G with an experimental mutation C111S exhibited low aggregation propensity. Overall, this study is an extension of previous work demonstrating that cysteine residues in mutant SOD1 play a role in modulating aggregation and that intermolecular disulfide bonds are not required to produce large intracellular inclusion-like structures.PLoS ONE 10/2012; 7(10):e47838. DOI:10.1371/journal.pone.0047838 · 3.53 Impact Factor
Article: A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo[Show abstract] [Hide abstract]
ABSTRACT: Mutations in superoxide dismutase 1 (SOD1) cause familial amyotrophic lateral sclerosis. The Cu-binding capacity of SOD1 has spawned hypotheses that implicate metal-mediated production of reactive species as a potential mechanism of toxicity. In past experiments, we have tested such hypotheses by mutating residues in SOD1 that normally coordinate the binding of Cu, finding that such mutants retain the capacity to induce motor neuron disease. We now describe the lack of disease in mice that express a variant of human SOD1 in which residues that coordinate the binding of Cu and Zn have been mutated (SODMD). SODMD encodes three disease-causing and four experimental mutations that ultimately eliminate all histidines involved in the binding of metals; and includes one disease-causing and one experimental mutation that eliminate secondary metal binding at C6 and C111. We show that the combined effect of these mutations produces a protein that is unstable but does not aggregate on its own, is not toxic, and does not induce disease when co-expressed with high levels of wild-type SOD1. In cell culture models, we determine that the combined mutation of C6 and C111 to G and S, respectively, dramatically reduces the aggregation propensity of SODMD and may account for the lack of toxicity for this mutant.Journal of Neurochemistry 02/2012; 121(3):475-85. DOI:10.1111/j.1471-4159.2012.07690.x · 4.24 Impact Factor
Article: Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative[Show abstract] [Hide abstract]
ABSTRACT: Recent studies have implicated an N-terminal caspase-6 cleavage product of mutant huntingtin (htt) as an important mediator of toxicity in Huntington's disease (HD). To directly assess the consequences of such fragments on neurologic function, we produced transgenic mice that express a caspase-6 length N-terminal fragment of mutant htt (N586) with both normal (23Q) and disease (82Q) length glutamine repeats. In contrast to mice expressing N586-23Q, mice expressing N586-82Q accumulate large cytoplasmic inclusion bodies that can be visualized with antibodies to epitopes throughout the N586 protein. However, biochemical analyses of aggregated mutant huntingtin in these mice demonstrated that the inclusion bodies are composed largely of a much smaller htt fragment (terminating before residue 115), with lesser amounts of full-length N586-82Q fragments. Mice expressing the N586-82Q fragment show symptoms typical of previously generated mice expressing mutant huntingtin fragments, including failure to maintain weight, small brain weight and reductions in specific mRNAs in the striatum. Uniquely, these N586-82Q mice develop a progressive movement disorder that includes dramatic deficits in motor performance on the rotarod and ataxia. Our findings suggest that caspase-6-derived fragments of mutant htt are capable of inducing novel HD-related phenotypes, but these fragments are not terminal cleavage products as they are subject to further proteolysis. In this scenario, mutant htt fragments derived from caspase 6, or possibly other proteases, could mediate HD pathogenesis via a 'hit and run' type of mechanism in which caspase-6, or other larger N-terminal fragments, mediate a neurotoxic process before being cleaved to a smaller fragment that accumulates pathologically.Human Molecular Genetics 07/2011; 20(14):2770-82. DOI:10.1093/hmg/ddr176 · 6.68 Impact Factor
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McKnight Brain InstituteGainesville, Florida, United States


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How did three Danes end up being tortured in Lebanon?
What a crisis has done to the people of Greece
03 Nov 2010 09:23 GMT | Politics, US & Canada, Iraq, United States
" />
The world has entered a new arms race at a time of relative peace, totalling $1.5 trillion, that is $217 for every person on the planet.
The Arms Race
The Asian Arms Race
Over the last decade, Washington has doubled its military budget, fuelling massive military build-ups around the world, from the emerging powers in the South China Seas to the multi-billion-dollar arms deals in the Middle East, begging the question where and when this vicious cycle of rising military expenditures will end.
Aside from the strategic dimension, leaders and pundits have also advanced the economic case for their excessive spending, both in terms of supply and demand.
Apart from the extensive profits from selling arms, the military industry creates thousands of manufacturing jobs in the shadow of the latest international economic crisis and high unemployment.
However, considering that spending on the military takes away from other higher-yielding, less costly and more important sectors of the economy, Empire asks: What justifies this global military addiction, or, has the world been duped by the multi-national, military industrial complex?
Joining the discussion are Robert Kaplan from the Center for New American Security, Ellen Laipson, CEO and president at the Stimson Center, Joseph Cirincione, the president of Ploughshares Fund, and Ambassador Richard Butler, the former chief weapons inspector, Iraq.
This episode of Empire can be seen from Wednesday, October 27, 2010 at the following times GMT: Wednesday: 1900, Thursday: 1400; Friday: 0300; Saturday: 1900;
Source: Al Jazeera
Changing climate, unpredictable rains dry out the land, threaten the pastoral way of life in Somaliland.
Poverty & Development, Environment, Africa
Tensions rise as Greeks from both side of the bailout debate take to the streets to withdraw money and express angst.
Politics, Europe, Greece
The world's biggest producer and consumer of the metal sees a golden opportunity to expand its pricing power.
Business & Economy, Asia, China
Normalised Cuba-US relations could result in a hybrid economic model blending socialism and entrepreneurial spirit.
Business & Economy, Communism, Politics
An inside look at the devastating impact of the Greek financial crisis on ordinary citizens.
Business & Economy, Europe, Greece
Can Afghan archaeologists take on the Chinese and the Taliban to save a 5,000-year-old archaeological site?
Arts & Culture, Asia, Afghanistan
In war-torn Afghanistan it is not the Taliban that poses the greatest threat to women - it is their own families.
Human Rights, Women, Afghanistan
After decades of tension and hostility between the two nations, has change finally come to US-Cuba relations?


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a contraction, combining the words "man" and "ego." Used to decribe the inflamed, swollen mass that is the male ego. Can double as an adjective.
2.Some guys have a hard time receiving instruction from women. Blame the mango...
1.I'm training the new guy at work, and he's clearly having trouble. I'd offer up some tips, but he's gone all mango on me...
1.I'm training the new guy at work, and he's clearly having trouble. I'd offer up some tips, but he's gone all mango on me...
dodane przez Megmegmeg wrzesień 08, 2007
to bust a nut upon a males face
that fag just mango'd that dude
dodane przez oneflymofo czerwiec 06, 2007
Cuban word for ordinary vagina.
Especially good vagina is called papaya.
Especially good vagina is called papaya.
Mango is always good, but, oh, man, papaya is extra special!
dodane przez sylmngyzr kwiecień 25, 2007
To be overly strong or have the strength of 10 men. The hulk without the Green skin tone, superman without the flight, literally can have the whole world in his hands.
That little boy is trapped under the bus...can you lift it? No what do you think I am, Mango?
dodane przez LarryDSSS lipiec 14, 2006
Mango meaning gangster. originated from the italien mafia, mango, mango'd getting mashed up..
Dont mess with him hes a mango
dodane przez whogoesyoudecide grudzień 29, 2004
a really stupid yellow dog that always excapes from mas house when you leave the door/gate open. also smells like a freshly taken shit and is very playful.
mango you smell like a freshly taken shit.
close the door so mango doesnt get out.
close the door so mango doesnt get out.
dodane przez big tim sierpień 25, 2004
to scare the beejesus out of someone, often by unexpectedly appearing next to them
Blair sure mangoed me when he jumped out from behind that van.
dodane przez Hippopottoman czerwiec 15, 2004


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(My wife and I going to the hospital while she's in labor.)
Me: Excuse me, my wife is in labor.
Nurse: OK, is she having contractions?
Me: Yes!
Nurse: How bad are they?
Wife: (In the middle of a contraction) I WILL F**KING KILL YOU FOR THIS!!!!
Me: That bad.
(Me eating a chocolate orange on sofa, dad who is on a diet next to me)
Dad: I hope you die in pain.
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Triaxon XP Aminomax 3-in-1 Spray Gel is botanically enriched and infused with spearmint extracts. It can be used as a volumizer, to help create great looking body and style. Use it as a stylish gel to help add shape, dimension and shine, or it can be used as a styling spray to help hold your finished look in place. Use everyday, or as needed, this spray gel is never sticky, and alcohol free.
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The Message audio Bible is now available on Bible Gateway! Click to learn more.
4:16 the ark of the testimony. Also called the ark of the covenant (Ex. 25:16, 21, 22; 31:18; 32:15; 40:20). The Ten Commandments were deposited in the ark as a testimony to the agreement God made with Israel.


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Off-season Madness V: Your cable bill is going up|Presser Tue @ 9:30am ET/6:30am PT
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Location: London
Posts: 5,683
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Originally Posted by
Guaranteed Contracts
Jose Reyes, SS: $96MM through 2018
Mark Buehrle, SP: $52MM through 2015
Jose Bautista, OF: $43MM through 2015
Edwin Encarnacion, 1B: $29MM through 2015
Ricky Romero, SP: $23.1MM through 2015
Brandon Morrow, SP: $17MM through 2014
Melky Cabrera, OF: $16MM through 2014
Josh Johnson, SP: $13.75MM through 2013
Maicer Izturis, IF: $10MM through 2015
Sergio Santos, RP: $7.25MM through 2014
Adam Lind, DH: $7MM through 2013
John Buck, C: $6MM through 2013
Casey Janssen, RP: $3.9MM through 2013
Dustin McGowan, SP: $3.5MM through 2014
Darren Oliver, RP: $3MM through 2013
Rajai Davis, OF: $2.5MM through 2013
lind and buck = 13M per
dump that and sign Swisher
mr consistency:
and he's a swish-hitter
Just did some quick math and that gives us an average of $126. I know it wont be that when you factor in Reyes and Beurhles salary only being 10m each.
Damn its good to see us having a good starting team on paper (even better if Romero can get back to where he was) and lots of good prospects in the farm.
Swisher would be a good depth move. But I still see a deal for another pitcher coming to give us five solid starters.
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I agree with much of that. I would disagree about Rees though. He actually looked really good. He made a lot of perfect passes into good coverage. He only really made one really bad throw. the first interception he threw was off the helmet of his receiver who wasn't paying attention. The other interception he threw was into double coverage, and there really wasn't anywhere for him to fit the ball in, just a bad decision.
The turnovers are slightly overrated in this game. I heard Kirk Herbstreit say that the fumble return was a 14 point swing. He fails to realize that it was a 3rd down and goal, so even if there was no fumble, they probably would have settled for a field goal attempt. You can't say that it was a 14 point swing. 10 tops. Same thing with the interception in the endzone. That was a 3rd down play. Even if it were an incomplete pass, Notre Dame would have settled for a FG attempt. Obviously turnovers were a big deal in the game, but it isn't as bad as some people are making it out to be.
Also, the reason USF picked off a couple of those passes (not the one off the helmet) was because ND was making risky throws all game. They were high risk/high reward plays. When you are consistently squeezing the ball passed defenders and dropping perfect passes in between a linebacker and a safety, it isn't always going to go your way. If you take the incredible plays, you also have to take the interceptions as a natural consequence rather than a fluke (or cheap) play.
Yardage is also overrated. It was clear that USF was playing a very conservative game offensively, and their strategy on defense was to not give up the big play. Holtz even said as much: "we took the mindset, bend but don't break, bend but don't break, let's not give up the home run ball. I think Michael Floyd is a great player on film. I think he's a lot better than he is on film. I think he is one of the special players in college football. I think he's a difference maker. He is special. And because of him when we just turned and said let's try and make sure we keep him in front of them. Even trying to do that he still caught one later. But the whole mindset was bend, don't break. Our motto was make them snap it again, don't just let them in the end zone, make them snap it again. I don't care if it's a 20 play drive. They haven't scored yet if they don't cross that end zone. Don't let them in the end zone, make them drive the field, don't give them anything cheap. "
You can't measure the players performance purely on yards. Yards aren't all that important. Especially when you're playing with a lead and your trying to bleed the clock. Obviously ND played a great game - particularly Floyd and Rees. But the game wasn't as lopsided as the stats would indicate.


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6 Joshua (The Story: A Musical Journey Through the Bible - Act 1 Scene 5) - Ministry Videos
Embed crossroadschurchga 447 views 2013-03-29T10:49:04 Crossroads Fellowship Church, Augusta, GA. From our musical drama based on "The Story".
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Album Rating: 4.5http://www.bluecollardistro.com/isis/product_info.php?products_id=2944&cPath=243_244&store=0
Album Rating: 5.0Truth.
Mine is over there.
This and panopticon are the best ones. But abscense and wavering have a lot of sick tunes
So does Celestial but thats worst Isis.
Album Rating: 5.0Dominion you are my hero.
Album Rating: 4.0did u even look
Album Rating: 5.0Yeah. Was on their page, actually, but I must have glanced over it somehow. Momentary lapse of brain.
Album Rating: 2.5wow what happened to you pops? got a bang on the head?
Album Rating: 5.0Yessir.
Album Rating: 2.5that was directed to KILL lol sorry
Album Rating: 5.0Oh. Context was pretty minimal haha.
damn good so far
s'gotta couple thingies yea
Album Rating: 4.5Weight is 6/5
Digging: Hive Destruction - Hive Destruction
Its off the scales
Album Rating: 4.5So does Celestial but thats worst Isis.
Nah, Celestial is better than Absence
Album Rating: 4.0oceanic > panopticon
Album Rating: 4.5I don't agree, but love this so much that I don't care to argue either
Album Rating: 4.0this is good but not as good as the other one
Bands: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


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Book your room at Duna Hotel
Standard Room, 1 Double or 2 Single Beds, No WindowsMax Occupancy: 3 guests (up to 2 children, 1 infant)
Superior Room, 1 Double or 2 Single BedsMax Occupancy: 4 guests (up to 3 children, 1 infant)
Deluxe Room, 1 Double or 2 Single BedsMax Occupancy: 4 guests (up to 3 children, 2 infants)
Family RoomMax Occupancy: 4 guests (up to 3 children, 2 infants)
Get an overview of this hotelHo Chi Minh City hotel in Pham Ngu Lao with 24-hour front desk
Located in Pham Ngu Lao, this hotel is within a 10-minute walk of September 23 Park, Zen Plaza, and Ben Thanh Market. Museum of Fine Arts and Mariamman Temple are also within 10 minutes.
Hotel Features
24-hour room service, dry cleaning, and a 24-hour front desk are available at this hotel. WiFi in public areas is free. Additionally, a computer station, tour/ticket assistance, and multilingual staff are onsite.
Room Amenities
All 40 rooms offer free WiFi, 24-hour room service, and flat-screen TVs with cable channels. Refrigerators, minibars, and free bottled water are among the other amenities available to guests.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Duna Hotel features tour/ticket assistance, multilingual staff, and dry cleaning/laundry services. A computer station is located on site and high-speed wireless Internet access is complimentary. For a surcharge, a roundtrip airport shuttle (available on request) is offered to guests. This Ho Chi Minh City hotel also offers 24-hour room service, a safe deposit box at the front desk, and an elevator (lift).
- Free WiFi
- Airport transportation (surcharge)
- Dry cleaning/laundry service
- 24-hour front desk
- Computer station
- Tours/ticket assistance
- Multilingual staff
- Safe-deposit box at front desk
- Elevator/lift
- Luggage storage
- Number of buildings/towers - 1
- Number of floors - 10
- Total number of rooms - 40
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Room Amenities
- Free WiFi
- Minibar
- Room service (24 hours)
- Flat-panel TV
- Cable TV service
- Refrigerator
- Shower/tub combination
- Daily housekeeping
- Free bottled water
- Hair dryer
- In-room safe
- Free toiletries
- Desk
- Air conditioning
- Climate control
- Private bathroom
Where to Eat
24-hour room service is available.
Hotel Policies
Check-in time starts at 2 PM
Check-out time is noon
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! Children under 9 years old stay free when using existing bedding.
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No pets or service animals allowed
We should mention
This property offers transfers from the airport (surcharges may apply). Guests must contact the property with arrival details 48 hours prior to arrival, using the contact information on the booking confirmation. Children 9 years old and younger stay free when occupying the parent or guardian's room, using existing bedding. Only registered guests are allowed in the guestrooms. No pets and no service animals are allowed at this property.


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Wilco's Jeff Tweedy Announces Solo Tour
By Lindsay Zoladz on September 9, 2013 at 8:17 p.m. EDT
Next month, Wilco will play two consecutive weekends at the Austin City Limits Festival, and, according to a press release, "these will be the last Wilco shows for many months." However, frontman Jeff Tweedy announced a short solo tour out west this winter. Dates below.
Watch: Wilco Cover the Replacements With Tommy Stinson, Daft Punk's "Get Lucky" at Solid Sound
By Evan Minsker on June 22, 2013 at 12:17 p.m. EDT
Photo by Mitch Manzella
Update: The entire set is available for streaming/download at NYC Taper.
Wilco are headlining two nights of their Solid Sound Festival. Their first set last night was all covers. As Consequence of Sound points out, the setlist was heavy on classic rock (the Beatles, the Kinks, Neil Young, the Velvet Underground, Thin Lizzy, Bob Dylan, etc.) and featured several special guests (including Yo La Tengo). Below, watch them cover Daft Punk's "Get Lucky", plus the Replacements' "Color Me Impressed" with Tommy Stinson himself.
Update: Check out their performance of Pavement's "Cut Your Hair".
Photos: Animal Collective, Wu-Tang Clan, Grizzly Bear, Passion Pit, Charli XCX, more at Bonnaroo
By Pitchfork on June 16, 2013 at 7:30 a.m. EDT
Photos by Mitch Manzella and Pooneh Ghana. Above photo by Pooneh Ghana.
The second day of Bonnaroo went down Friday with sets by Animal Collective, Wu-Tang Clan, Grizzly Bear, Passion Pit, Charli XCX, and many more. Photographers Mitch Manzella and Pooneh Ghana were there. Check out a selection of shots after the jump, then head over to our slideshow and Facebook page for even more photos.
Watch: Wilco's Glenn Kotche Drums on Faucets in Bizarre Television Commercial
By Jenn Pelly on May 9, 2013 at 11:00 a.m. EDT
Although Wilco's music has appeared in ads before-- for example, a Sprint ad last year featured hundreds of smartphones playing "I'm Always in Love"-- a television commercial for Delta Faucet (yes, for sinks) is about the last place you'd expect to see Glenn Kotche.
Bob Dylan Announces Tour With Wilco and My Morning Jacket
By Evan Minsker on April 21, 2013 at 6:02 p.m. EDT
Photo by John Shearer
Bob Dylan has announced that this summer, he'll launch the AmericanaramA Festival of Music tour (via Consequence of Sound). He's bringing along three huge supporting acts: Wilco, My Morning Jacket, and Richard Thompson. There aren't any tour details just yet, but tickets go on pre-sale this Wednesday. Update: Check out the dates below.
Win a Recording Session With Wilco's Jeff Tweedy
By Evan Minsker on March 2, 2013 at 11:48 a.m. EST
Photo by Loren Wohl
Right now, Chicago high school Northside College Prep is hosting an auction online to help raise money for the school. And there's one particularly big ticket item up for grabs: an eight-hour recording session with Wilco's Jeff Tweedy at the Wilco Loft.
Yo La Tengo, Low, Neko Case, Foxygen to Play Wilco's Solid Sound Festival
By Jenn Pelly on February 14, 2013 at 4:37 p.m. EST
After a hiatus in 2012, the Wilco-curated Solid Sound Festival is returning this summer to the Massachusetts Museum of Contemporary Art, from June 21-23.
Watch Jeff Tweedy, Mavis Staples, Sean Lennon Sing "Happy Xmas (War Is Over)" on "Colbert Report"
By Carrie Battan on December 14, 2012 at 9:49 a.m. EST
"The Colbert Report"'s Christmas Carol Week finished last night, as Stephen Colbert enlisted Wilco's Jeff Tweedy, Mavis Staples, Sean Lennon and the Harlem Gospel Ghoir for a rendition of John Lennon and Yoko Ono's politically charged Christmas carol "Happy Xmas (War Is Over)". Watch it below.
Wilco's Solid Sound Festival to Return in 2013
By Carrie Battan on November 30, 2012 at 11:45 a.m. EST
The Wilco-curated Solid Sound Festival will return in 2013 after a hiatus in 2012. It takes place at the Massachusetts Museum of Contemporary Art in North Adams, Massachusetts from June 21 to 23. The full lineup of musicians, comedians, and visual artists haven't been announced yet, but Wilco will perform on two of the nights, and John Hodgman will star in a comedy cabaret.
Watch: Adorable Animated Monsters Abound in Wilco's Video for "Sunloathe"
By Jenn Pelly on September 19, 2012 at 3:50 p.m. EDT
Wilco have released a new animated clip for The Whole Love's "Sunloathe", a creation of director Peter Glantz and illustrator Nathaniel Murphy (who is also Glenn Kotche's touring drum tech and contributed illustrations to 2007's Sky Blue Sky). The clip opens with animated cat creatures taking over a house in the woods with pitchforks, before depicting other adorable monsters and medieval imagery and growing increasingly psychedelic.
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College Soccer Reporter
> Tuesday, Aug. 16, 2011
Soccer America Women's Preseason All-Americans
by Soccer America
[AWARDS] Melissa Henderson and Jessica Schuveiller of defending national champion Notre Dame are among 25 women named Soccer America's Preseason All-Americans. Boston College leads all teams with three players on the preseason team. Stanford, ranked No. 1 in the Soccer America Preseason Top 25, is the only other team with ...
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#3 North Carolina: Underdog role suits Heels
by Paul Kennedy
[TOP 5 PREVIEW] So many times North Carolina has been wiped out by graduation and come back to win a national championship that you just assumed it will always be the case. Well, that didn't happen last year, as the Tar Heels fell to Notre Dame, 4-1, in the NCAA ...
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BU picked to make it five in a row
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[AMERICA EAST WOMEN] Winner of four straight America East women's titles, Boston University is the unanimous selection to be crowned conference champion in 2011.
Read the whole story
Northern Arizona edges Sac State in poll
by Soccer America
[BIG SKY WOMEN] Big Sky coaches elected Northern Arizona as a slight favorite over Sacramento State to win the 2011 conference championship.
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Toledo and Miami tabbed as divisional champs
by Soccer America
[MID-AMERICAN WOMEN] Miami, Ohio, and Toledo were tabbed to finish first in their respective divisions in the Mid-American Conference.
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Creighton selected to repeat
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[MISSOURI VALLEY WOMEN] Defending regular-season and tournament champ Creighton has been picked by league coaches to win the 2011 Missouri Valley women's title.
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Picture: A. J. McLean (L) and Nick Carter of Backstreet Boys, performing on stage at the Molson Canadian Amphitheatre Toronto, Canada - 14.08.10
'He wanted to come on the tour with us and we all thought it was a great match. It's a big, exciting event. We're all pulling a lot of things together." Nick Carter on taking Glee star Matthew Morrison on the road with the Backstreet Boys and New Kids On The Block this summer (11)


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: FireRed hack:
Pokemon Fuligin
View Single Post
September 27th, 2012 (08:09 PM). Edited September 29th, 2012 by LassLaura.
No, I don't want a breakfast burrito
Team Kanto
Join Date: May 2010
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Posts: 158
For all the people asking about Sun Stones earlier: you can steal them from Solrocks in Lore Cave (the cave that runs from Spear City to Brox City). The chance one'll actually be carrying a Sun Stone is rare, though.
Quote originally posted by
anybody know were to get a mr mime or a pineco and how do u evolve pineco ty in advance
View original post
Pineco (according to mine's "met on" data) is found on Route 10. A visit to Bulbapedia can tell you how it evolves.
Mr. Mimes are on Route 32. You won't be getting there for a while.
Edit: grinding on Solrocks and Lunatones is great for raising Attack and Sp. Attack EVs. My Alakazam just gained 7 points in the latter by killing Lunatones exclusively 0_0
Edit 2: OMG shiny Bagon!
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Sunset Cocktails and (free) Live Jazz
- Music
- 420 Park Avenue South, New York, NY, 10021
Indie Corner @ Engadget Expand NY 2013
Engadget's Consumer Technology Event
Friday, November 8, 2013 at 8:00 AM - Sunday, November 10, 2013 at 5:00 PM (EST)
Engadget Expand is the consumer electronics experience. Fans of gadgets and new technology, and the companies that make them, come together for the love of tech in a fun, immersive, hands-on environment.
Expand NY will be held November 9-10 at the Javits Center (North Hall).
DISCLOSURE: Tickets may be transferred; please see How to Change Ticket Holder.
REFUND POLICY: No refunds will be given for Indie Corner.
For more information on the event,please head over to the official Engadget Expand page.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Tags » Knitting Factory
Interesting Events Happening Around Spokane May 15 - May 21, 2015
Friday, May 15, 2015
Jon Spencer Blues Explosion, We Are Hex are playing at 8:00 at The Bartlett (228 W. Sprague Ave).
Saturday, May 16, 2015… 170 more words
Lie to Me
St. Patrick's Day Kimber and I went out on the town to watch the AMAZING Blues artist, Johnny Lang at The Knitting Factory. My parents had a date night with us, yes I still party with my parents. 127 more words
Snoop dropz it at The Knit in Spokane!
Snoop Dogg visited The Knitting in Spokane. He was awesome. I love it.
Here are five things that I think were totally cool about the concert: 55 more words
INTERVIEW: From Indian Lakes
By: Sarah Dill
From the sprawling mountains of Yosemite to headlining shows across the country, From Indian Lakes have had a very busy couple of years. 2,087 more words
Tonight: Secret Someones at The Knitting Factory
Tonight, Secret Someones are back in New York City for the night and they headline the show at The Knitting Factory in Williamsburg. Hannah Winkler… 140 more words


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The 72-year-old is still finding time to serve as an ambassador for a cause close to his heart, Helping a Hero.
The Dixie Chicks can now claim another platinum CD, as their latest, Taking the Long Way, just hit the million sales mark four weeks after its release.
The CD is also seeing success outside the U.S., with sales of two million in Canada and one million in Australia. Taking the Long Way has been at the top of the Billboard country albums chart for five weeks, despite receiving little airplay at country radio, and was also the nation's No. 1 Top Digital Album. The Chicks continue their Accidents & Accusations Tour in Detroit on July 21 and Pittsburgh July 22.
More News
Scotty steps up to the plate as we celebrate America's Pastime.
Couple tied the knot on June 28.
"Trisha Yearwood: The Song Remembers When" opens to the public July 3.
Song will also appear in commercials for Greater Texas Ford Dealerships during July.
Dierks Bentley, Luke Bryan, Brad Paisley and Others Bring Country to New York at FarmBorough Festival
Country music is alive and well in NYC.


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Earth, Wind & Fire: Ticket
Verizon Theatre at Grand Prairie • Grand Prairie, TX
Sunday, October 6
What you get
- $35 for One 200-Level Ticket
- Hear All The Hits -- '70s Funk Legends Live!
"Shining Star," "September," "Let's Groove": You know all the hits by heart, now experience them live once again when Earth, Wind & Fire hits Verizon Theatre at Grand Prairie on Sunday, October 6 as part of the Now, Then & Forever Tour. These '70s icons became one of the most popular funk bands of all time, eventually endearing them to millions of fans around the world and ensuring EWF's legacy lives on to this day.
Find out more about Earth, Wind & Fire
Fine printREFUND POLICY: This event is nonrefundable. No full or partial refunds are given to customers who miss an event. In the event of a cancellation, your voucher will be fully refunded • Each voucher is good for 1 person • The deal is valid on event date only • Purchaser must pick up ticket(s) at Will Call prior to show • Purchaser may change the name of the individual retrieving tickets up to 24 hours in advance of event via the LivingSocial website event details section; no name-changes or alternate pick-ups permitted without notice at venue • Event is rain or shine • LivingSocial is pleased to offer you the opportunity to purchase this deal to be fulfilled by the entity indicated on the voucher and/or by Anschutz Entertainment Group, Inc., its subsidiaries and affiliates ("AEG"). By purchasing this deal, you agree that your name, email, zip code and other information related to the deal you purchased will be used by LivingSocial as well as provided by LivingSocial to AEG and/or the entity indicated on the voucher to assist in fulfilling the deal you purchased and, subject to LivingSocial's privacy policy [livingsocial.com/privacy_policy] as well
Earth, Wind & Fire: Ticket
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The Amy Butler Marni Duffle Bag is perfect for that weekend get-away or family outing. This tote bag is made of organic cotton, with woven trim, leather handles and piping, interior pockets and coordinating contrasting lining. Features:
- Made of organic cotton with woven trim
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- Style: Flatweave Stripe Emerald
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Podolski wants Arsenal to join Lewandowski transfer battle
Lukas Podolski would like to see Arsenal compete for Borussia Dortmund striker Robert Lewandowski.
Podolski is a big fan of Lewandowski and would love to see him arrive at the Emirates.
Podolski told the Polish press: "He would fit ideally into our team."


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Contact the Department of Political Science and Criminal Justice
Letter from the Chair
Welcome to the Department of Political Science, Criminal Justice and Organizational Leadership!
Our department includes more than 1,400 NKU students majoring in undergraduate programs of Criminal Justice, International Studies, Political Science and Organizational Leadership as well as our nationally accredited Public Administration graduate program.
It's an exciting time to be part of our department. New research opportunities have developed with the addition of new faculty, who are conducting applied research with local governments, non-profit organizations and public agencies. They are also developing regional coalitions, needs assessments, writing grants and writing books that often include students or student philanthropy as the focus of their manuscripts.
Check out what our faculty members are doing in the faculty bios on our website. I encourage you to contact them directly to get involved or seek their assistance. Now is the time to move out of the confinement of our current interests, boundaries and traditional ways of thinking and extend our approaches to defining and discovering new knowledge and new learning opportunities.
You may find such opportunities among the programs and faculty in the Department of Political Science and Criminal Justice.
- For more information about becoming a political science, criminal justice or international studies major, please contact Professor Caroline Braden at firstname.lastname@example.com
- For more information about becoming an organizational leadership major, please contact Megan Downing at firstname.lastname@example.com
- For information about the public administration minor or the Master of Public Administration program, contact Professor Beth DeVantier at firstname.lastname@example.com.
- Interested in applying for and participating in an internship? Check out our internship page on the website and contact Professor Caroline Braden at email@example.com if you have any questions.
Thank you for your interest in the Department of Political Science and Criminal Justice. Please take some time and visit our web pages for information about our program requirements, scholarships, internships, student groups and faculty.
The department continues to be interested in new ways to challenge and engage its students. Please feel free to stop by our offices on the fourth floor of Founders Hall and share your ideas. We look forward to working with students to make a difference at NKU and with our regional partnerships.
Chair and Professor
Founders Hall 439 / (859) 572-6402


text: The JPMorgan Chase building in London, where traders ran up huge losses. Timur Emek/AP hide caption itoggle caption Timur Emek/AP The Two-Way Whale Of A Fine: JPMorgan Chase To Pay $920M In Penalties September 19, 2013 Traders in JPMorgan's London offices racked up huge losses last year and then tried to cover up what happened. Now, the bank is admitting the violations and agreeing to pay nearly $1 billion to regulators in the U.S. and U.K. Listen Loading… 4:00 Playlist Download Embed Embed Close embed modal <iframe src="http://www.npr.org/player/embed/224038157/224049402" width="100%" height="290" frameborder="0" scrolling="no">


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My grand daughter loves it. It was used to supplement a discussion with her dad regarding heredity and why she has her grand mother's eye color and brows.Published 2 months ago by k mauro
The illustrations are very helpful in communicating Mendel's scientific process.Published 2 months ago by Annie Perkins
Really wordy, not that great for young kids. Better for middle schoolers studying genetics.Published 3 months ago by Lisa Wojcik
Great book, explains Mendel's life and contributions in a simple but not dumbed-down way. Makes my 7 year old want to study genetics!Published 4 months ago by Una Cartwright
Very nice book to teach genetics to kids. We use this in our homeschool.Published 4 months ago by K. Tripp
I read this book to my high school students. They don't love the book, but they do love story time and it has just enough science that you can read it as the intro OR as a... Read morePublished 14 months ago by Jones
I bought this as background material for my middle school General Science class. My own children (10, 12 and 16) loved the book. Read morePublished 17 months ago by Dkx
This book is wonderfully illustrated and contains very important facts about heredity and traits. A wonderful book fo incorporating science into reading time.Published 22 months ago by DonnaJ