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Exogenously administered D-serine failed to potentiate the ability of MK-801 to antagonize electrically precipitated seizures in nonhandled control and stressed mice
ABSTRACT NMDA receptor hypofunction (NRH) has been implicated in the pathophysiology of schizophrenia because of the ability of phencyclidine (PCP), a noncompetitive NMDA receptor antagonist, to precipitate a schizophreniform psychosis. The possible role that NRH plays in the pathophysiology of schizophrenia stimulated characterization of behaviors elicited by PCP and its analogues. For example, MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist that binds with higher affinity to the same hydrophobic channel domain as PCP, raises the threshold voltage required for the electrical precipitation of tonic hindlimb extension in mice. This ability of MK-801 is significantly reduced following stress. We showed that an exogenously administered glycine prodrug (i.e., milacemide) was able to potentiate MK-801's antiseizure efficacy in unstressed mice and restore MK-801's antiseizure efficacy in stressed animals. d-Serine may serve as an endogenous agonist for the obligatory glycine co-agonist site on the NMDA receptor complex. Orally administered d-serine has been studied clinically as an adjuvant therapeutic intervention in schizophrenia. Thus, we were surprised at its inability to potentiate MK-801's antiseizure efficacy in either control or stressed animals. These data do not support the development of d-serine as a viable therapeutic intervention for schizophrenia and, possibly, other disorders.
- SourceAvailable from: Alessandro Gozzi
Article: Pharmacological stimulation of NMDA receptors via co-agonist site suppresses fMRI response to phencyclidine in the rat.[Show abstract] [Hide abstract]
ABSTRACT: Increasing experimental evidence suggests that impaired N-methyl-D: -aspartic acid (NMDA) receptor (NMDAr) function could be a key pathophysiological determinant of schizophrenia. Agonists at the allosteric glycine (Gly) binding site of the NMDA complex can promote NMDAr activity, a strategy that could provide therapeutic efficacy for the disorder. NMDAr antagonists like phencyclidine (PCP) can induce psychotic and dissociative symptoms similar to those observed in schizophrenia and are therefore widely used experimentally to impair NMDA neurotransmission in vivo. In the present study, we used pharmacological magnetic resonance imaging (phMRI) to investigate the modulatory effects of endogenous and exogenous agonists at the NMDAr Gly site on the spatiotemporal patterns of brain activation induced by acute PCP challenge in the rat. The drugs investigated were D: -serine, an endogenous agonist of the NMDAr Gly site, and SSR504734, a potent Gly transporter type 1 (GlyT-1) inhibitor that can potentiate NMDAr function by increasing synaptic levels of Gly. Acute administration of PCP induced robust and sustained activation of discrete cortico-limbo-thalamic circuits. Pretreatment with D: -serine (1 g/kg) or SSR504734 (10 mg/kg) completely inhibited PCP-induced functional activation. This effect was accompanied by weak but sustained deactivation particularly in cortical areas. These findings suggest that agents that stimulate NMDAr via Gly co-agonist site can potentiate NMDAr activity in the living brain and corroborate the potential for this class of drugs to provide selective enhancement of NMDAr neurotransmission in schizophrenia.Psychopharmacology 09/2008; 201(2):273-84. DOI:10.1007/s00213-008-1271-z · 3.99 Impact Factor
Article: Expression of NR1, NR2A and NR2B NMDA receptor subunits is not altered in the genetically-inbred Balb/c mouse strain with heightened behavioral sensitivity to MK-801, a noncompetitive NMDA receptor antagonist.[Show abstract] [Hide abstract]
ABSTRACT: The genetically-inbred Balb/c mouse strain shows heightened sensitivity to the ability of MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist, to raise the threshold voltage necessary to precipitate tonic hindlimb extension and elicit irregular episodes of intense jumping behavior (referred to as "popping"), relative to other inbred mouse strains and the outbred NIH Swiss mouse. Moreover, an allosteric modulatory effect of sarcosine, a glycine reuptake inhibitor, on MK-801's antagonism of electrically precipitated seizures was detected 24 h after Balb/c mice were forced to swim in cold water for up to 10 min; this was not observed in unstressed Balb/c mice or stressed or unstressed NIH Swiss mice. Phencyclidine (PCP), a noncompetitive NMDA receptor antagonist that binds to the same hydrophobic channel domain as MK-801, precipitates a schizophreniform psychosis in susceptible individuals that shares descriptive similarities with schizophrenia. This observation has led to the hypothesis that NMDA receptor hypofunction (NRH) is involved in the pathophysiology of schizophrenia and the testing of pharmacotherapeutic strategies to facilitate NMDA receptor-mediated neurotransmission in patients with this disorder (e.g., glycine reuptake inhibitors). The heightened behavioral sensitivity of the Balb/c mouse to MK-801 suggests that this mouse strain may be a useful model to study "psychosis-proneness" and screen for positive allosteric modulators of NMDA receptor-mediated neurotransmission. Conceivably, strain differences in the pharmacology of the NMDA receptor are due to differences in the relative expression of individual NMDA receptor subunits to each other (i.e., combinatorial regulation). The current study compared the normal protein expression patterns of six of the eight identified splice variant isoforms of the NR1 NMDA receptor subunit, and NR2A and NR2B subunits in the hippocampus and cerebral cortex of Balb/c and NIH Swiss mice. The heightened behavioral sensitivity of the Balb/c genetically-inbred mouse strain to MK-801, compared to the outbred NIH Swiss mouse strain, does not appear to result from relative alterations of expression of these NMDA receptor protein subunits that were examined.European Neuropsychopharmacology 08/2008; 18(11):814-9. DOI:10.1016/j.euroneuro.2008.06.004 · 5.40 Impact Factor


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Here we grow again! Our company, started in Grand Rapids, MI has grown into 3 locations with future stores in the planning stage. Our growth and expansion in the classic/collector car industry has given us the opportunity to expand into a much larger and state of the art facility. September 1, we are moving to a new 36,000 square feet showroom at 4722 50th Street. This will be close to where we are right now and closer to the airport to accommodate our out of town and international buyers. We are very excited and grateful for the support that has allowed us to grow and look forward to providing even better service to buyers and sellers in the future!
A high flat-topped hood was all the rage of this era and was very predominant of the 1940 model, as the grille spread out... More
Ford Motor Company introduced its De Luxe Ford line in 1938 as a more luxurious option to bridge the gap between its standard model... More
GR Auto Gallery is proud to present this 1979 Lincoln Continental Mark V Collector Series for purchase. Offered in Midnight Blue Moondust Metallic, the... More
The BMW Motorsports division has a very strong and impressive history of continuing to get everything out of its cars that is possible on... More
GR Auto Gallery is pleased to present this 2012 Ford Mustang Premium Convertible for purchase. The Mustang is as American as apple pie, but... More
In September 2009, a leaked photo of the new 2011 QX56 (Z62) prototype was published online and seen at a Las Vegas Infiniti national... More
Ridged US emission standards left many car manufacturers trying to find their way during the Mid 1970's. The US automakers who has such performance... More
GR Auto Gallery is pleased to present this 2002 Chevrolet Camaro Z28 Coupe for purchase. 35 years after taking over the pony car market... More
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We are pleased to offer this very cool, 1969 Chevrolet Camaro Z28 in striking Rally Green over White Interior, White Stripes and White Vinyl... More
After a 6 year absence from the US Market, The 930 was re-introduced to the America's as the 911 Turbo with much fanfare; the... More
GR Auto Gallery is pleased to present this 1964 Chevrolet Impala Hardtop Coupe for purchase. The Impala's 3rd generation ran from 1961 to 1964... More
Porsche developed the 914 as a replacement for its beloved 912, the four cylinder version of the 911. The 914 was intended to be... More
Pay attention to this car as it does not get much better when it comes to collectible muscle. Chevrolet holds nothing back when it... More
GR Auto Gallery is pleased to present this 1987 Ferrari 328 GTS for your consideration. The new model was a revised and updated version... More


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How to retrieve passwords from locked laptops
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In any case, if we assume the operating system has been locked, you're in luck as there are plenty of quality products that will allow you to unlock any account with a forgotten password. One which I frequently use is Winternal's ERD Commander 2005. The program is able to run directly from a CD, allowing you to boot from it and reset the administrator's or any other user's password.
If on the other hand you are referring to unlocking passwords set via the system's BIOS, then you do have a problem as no vendor gives out any of the in-house tools that will allow you to perform such tasks. In this case you will be forced to continue sending the laptops back to their vendor, so you don't void their warranty!
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Transportation Services
Welcome to the University of Louisiana at Lafayette and the Office of Transportation Services. We are the 'transportation' people and we're here to help you. Please look around our website to make sure you know the rules of the road when it comes to parking, transit and bicycling on campus.
Reminder: Gates which are up do not mean that anybody can park in that lot. We have several broken gates and there are some areas where we are not replacing gate arms. These areas are signed. Read all signage before you park. Questions? Just call us!
We have a Facebook page and Twitter accounts so please follow us for the latest news and information. There is a lot of activity on campus, so always ask before you park.
Need to appeal a parking citation? Please follow our online Citation Appeal.
Parking enforcement will occur through all University breaks and during the Summer Session(s). Please park in your permitted area only.
If you have any questions, call us 337-482-6858 or email us at email@example.com.
We also want you to be safe on campus. Please visit our new Bike Information area to learn all about the bicycle lanes on St. Mary Boulevard.


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Latest Food & Drink Industry News
Tuesday, July 7th, 2015, (3:30 pm)
Helen's gluten free brand unveils new look
Helen's, a brand in wheat and gluten free mixes and toppings, has a new look.
Helen's offers wheat and gluten free toppings, mixes, bread, desserts and much more – and because the mixes take so little time to make, consumers have more time to enjoy other things.
The new look showcases a big Helen's logo surrounded by colourful illustrations with on-pack imagery designed to appeal to the consumer. (more…)
Tuesday, July 7th, 2015, (1:12 pm)
Fruit-tella launched in £1 price-marked packs for the summer
Perfetti Van Melle has introduced a range of £1 price-marked packs (PMPs) across its best-selling sharing bags in a bid to drive rate of sale and profits for retailers during the summer months.
Available now in major wholesalers on special packs of Fruittella, Mentos and Klene, the price-marked grab bags offer a an opportunity for sales.
PMPs remain a key addition to shelves as they reassure consumers of a low price guarantee and allow retailers to predict profit margins and maximise sales through the increased demand. (more…)
Tuesday, July 7th, 2015, (11:06 am)
Are all your customers' experiences heading to the same sale?
As you know the way people buy food nowadays is so very different.
We have such significant growth in discounters, online, convenience and foodservice.
And as you know the large supermarkets have struggled to grow, even though of course they still make up a high proportion of sales – and this should feed into the way we think about NPD. (more…)
Tuesday, July 7th, 2015, (9:12 am)
Wrigley re-launches Spearmint flavour in Ice range
This month, Wrigley is bringing back its best-selling Extra Ice Spearmint flavour with a new improved taste and distinctive packaging design.
Designed to capitalise on the popularity of the spearmint flavour within the gum category, the reformulated flavour and fresh visual identity aims to inspire and excite consumers and drive home the brand's outstanding oral care credentials.
Available in 10 pellet packs with an RRP of 49p, the reformulated product features improved cooling and helps keep teeth clean in a way that you can feel. (more…)
Tuesday, July 7th, 2015, (7:00 am)
FDF launches gluten labelling guide
A new guide has been launched to support food manufacturers on the labelling of food products containing gluten.
The Food & Drink Federation (FDF) has launched a new best practice guide to help manufacturers adhere to the Food Information to Consumers (FIC) Regulation and to provide consumers with clear and consistent allergens labelling.
The FIC Regulation brought changes to the way allergen information is provided and emphasised on pre-packaged foods. (more…)
Monday, July 6th, 2015, (3:20 pm)
Elizabeth Shaw extends chocolate range
Chocolate brand Elizabeth Shaw has announced it is extending its chocolate range to include Bites – flavoured chocolate segments topped with sprinkles.
Bites will be available in Sainsbury's stores nationwide from the 29th June with an RRP of £2.50.
Following on from the success of its Flutes range, these smaller, bite-size chocolates aim to add a more contemporary feel to the whole range. (more…)
Monday, July 6th, 2015, (11:11 am)
Hovis unveils new pack designs
Hovis is rolling out a national campaign for its Seeded and Granary ranges this month, alongside new packaging designs.
The activity aims to reinforce the premium taste of the ranges through a widespread print advertising and shopper media campaign.
The fresh new packaging design aims to champion the superior ingredients and taste of Hovis seeded and granary loaves. (more…)
Monday, July 6th, 2015, (9:03 am)
Prestat launches new range of Posh Chocolate Spreads
Prestat has whipped its chocolate with six different nutty, fruity flavours to create a new range of "posh chocolate spreads".
From Heavenly Hazelnut and Plumptious Cherry to Rhapsodic Raspberry and Divine Clementine, nuts and fruits are all encased in chocolate made with cocoa from São Tomé, Ghana & Tanzania.
Consumers can seek out their favourite to create a treat by smothering it on anything from a croissant to the middle of a home baked cake. (more…)
Monday, July 6th, 2015, (7:00 am)
Tic Tac unveils new flavour-changing Mixers
Tic Tac is aiming to reinvigorate the market with the launch of a flavour-changing experience for consumers – Tic Tac Mixers
Available in two flavours – Cherry Cola and Peach Lemonade – the variants melt from their sweet fruit layer into a secondary flavour, i.e. Cherry to Cola and Peach to Lemonade.
Supported by a £1.3m integrated campaign, the launch will be widely seen by the target audience of 18 year olds upwards, driving awareness and encouraging trial. (more…)
Friday, July 3rd, 2015, (3:20 pm)
Primrose's Kitchen Raw Vegetable Mueslis get new stockist
Following the success of Primrose's Kitchen in department stores and supermarkets across the UK, the raw vegetable muesli can now be found in the aisles of health food store Holland & Barrett.
Holland & Barrett stores will stock Primrose's Kitchen Raw Vegetable Muesli in two flavours:
Beetroot and Ginger Muesli and Raw Carrot and Apple and Ginger Muesli. (more…)
Friday, July 3rd, 2015, (11:06 am)
Heineken unveils Rugby World Cup bottle
Heineken has unveiled its off-trade plans to support the 2015 Rugby World Cup, following the announcement last October that the brand would be the official beer sponsor of the tournament.
Heineken has produced limited edition packaging that will be available from July across 650ml bottles, 500ml cans and 330ml cans and bottles.
In addition, shoppers who purchase 12-packs will be in with a chance of winning a pair of tickets or the chance to toss the coin at the beginning of the match by finding one of 50 hidden golden bottles. (more…)
Friday, July 3rd, 2015, (9:00 am)
Tropicana launches new Essentials range
Tropicana has launched a new Essentials range, which includes fruit and vegetable juices packed with extra vitamins and minerals such as Tropicana Essentials Immune Support Orange Mango & Persimmon, and Essentials Fruit and Veg: Mango Passionfruit & Pumpkin.
The new juice drinks are made from fruits with extra vitamin c and zinc which help support a healthy immune system.
Each portion contains one of your five a day. (more…)
Friday, July 3rd, 2015, (7:00 am)
Ritz Crisp & Thin gets multimillion pound campaign
Mondelēz International is launching a brand new multi-million pound master-brand campaign for the launch of its new product, Ritz Crisp & Thin, a baked savoury snack.
The concept of the campaign is based around 'Putting on the Ritz' – the idea being that Ritz Crisp & Thin transforms every day snacking moments, adding a bit of ritziness.
Designed to open the Ritz brand to a younger audience, the campaign is aimed at a 24-45 year old demographic who love crisps and snacks. (more…)
Thursday, July 2nd, 2015, (3:20 pm)
Sheppy's launches new Blackberry and Elderflower Cider
Sheppy's is launching a new Cider with Blackberry & Elderflower.
The new cider combines blackberry with the floral overtones of elderflower.
Fruity and aromatic – this latest addition to the Sheppy's cider family hopes to appeal as a flavour for summer. (more…)
Thursday, July 2nd, 2015, (1:10 pm)
Zeo launches new 'lightly carbonated' range
Premium soft drinks brand zeo has launched four new flavours in time for summer.
All boast low sugar content and use only naturally sourced ingredients and botanicals – all without compromising on great taste.
The zeo collection includes: Peach & Grapefruit, Zesty Lime, Blood Orange & Citrus, and Mixed Berry. (more…)
Thursday, July 2nd, 2015, (11:12 am)
How do people buy food in 2015? – FDIN omnichannel seminar answers all
As you know the way people buy food nowadays is so very different.
We have such significant growth in discounters, online, convenience and foodservice.
And as you know the large supermarkets have struggled to grow, even though of course they still make up a high proportion of sales – and this should feed into the way we think about NPD. (more…)
Thursday, July 2nd, 2015, (9:04 am)
VITHIT extends its reach
Irish lifestyle drinks brand VITHIT has extended its reach into leading healthcare retailers, Boots and Superdrug.
The drinks will feature nationwide over the coming weeks and follow the recent expansion of listings throughout the Tesco estate.
The range offers a healthier alternative to sugary fruit juices and sports drinks and has become established throughout multiple retailer fixtures over the past 18 months. (more…)
Thursday, July 2nd, 2015, (7:01 am)
Tesco launches Sweet Summer Cabbage
Getting kids to eat their greens at dinner time has never been an easy job – as many long suffering parents will know.
But now that task should be a little easier as a sweeter variety of homegrown cabbage – a vegetable that is packed with nutrients – is to be trialled by Tesco.
The new variety, known as Sweet Summer Cabbage, is grown in Lincolnshire and has been naturally developed to re-generate interest in the vegetable. (more…)
Wednesday, July 1st, 2015, (3:12 pm)
Kellogg's launches new summer cereals
Kellogg's is launching a series of new breakfast and snack products.
The array of new foods is designed to be more diverse, and all were created with a laser-beam focus on driving growth in the breakfast and cereal snack categories.
The new Special K Protein Crunch is hitting the shelves in July, comes in the form of crunchy clusters. (more…)
Wednesday, July 1st, 2015, (1:20 pm)
Rustlers reveals push for new panini range
Rustlers, the micro-snacking brand, is backing its recently launched panini range with #RustlersOnTour, a national sampling campaign.
The activity, the biggest-ever sampling campaign for Rustlers, will run across 32 cities throughout the UK, sampling 80,000 consumers with products and money-off coupons, said Kepak Convenience Foods marketing director John Armstrong.
Brand owner Kepak says the sampling campaign will be backed by heavyweight social media activity on Rustlers' Facebook and Twitter channels, ensuring shoppers are on the lookout for #RustlersOnTour. (more…)
Wednesday, July 1st, 2015, (11:12 am)
High Protein Coconut Water launches in the UK
CocoPro, the world's first high protein coconut water has launched.
The drink combines 20 grams of whey protein (per 330ml serving) with the natural nutritional properties of coconut water to deliver muscle recovery and hydration in a post-workout drink.
CocoPro is made with 100% natural ingredients and no added sugar and is available in two variants, coconut and coconut with pineapple. (more…)
Wednesday, July 1st, 2015, (9:12 am)
John West unveils new Mackerel sauces range
John West is set to further enhance its entire mackerel sauces range with the addition of new foodie variants in a major new push.
The new range of seven products – which will appear on shelf from May onwards in major multiples – will consist of:
Sundried Tomato and Basil, Tomato & Chilli, Dijon Mustard, Teriyaki, Sweet Chilli, Mexican, Korma. (more…)
Wednesday, July 1st, 2015, (7:09 am)
Lupetta expands sauce line with mushrooms, capers and olives
Last year, Donatantonio launched Lupetta, a line of Italian store cupboard essentials, answering to consumer culinary interest in provenance and regionality.
The Lupetta Cherry Tomato Sauce was part of the original range, and since has been joined by the Cherry Tomato Sauce with Porcini Mushrooms and the Cherry Tomato Sauce with Olives & Capers.
The sauces aim to respond to the consumer trend for higher quality, artisan products from independent producers. (more…)
Tuesday, June 30th, 2015, (3:30 pm)
New ice cream brand Emily's launches
Emily Watkins, Chef Proprietor at The Kingham Plough and previous contestant on BBC's Great British Menu, has launched a range of homemade ice creams.
The range includes four flavours, Lemon & Honeycomb, Forced Rhubarb, Toffee Apple and Elderflower & Raspberry, and is available in 110ml and 500ml tubs.
Emily's Ice Cream will be available to purchase from The Kingham Plough, for just £2 for a 110ml tub and £5 for 500ml. (more…)
Tuesday, June 30th, 2015, (1:10 pm)
New Yushoi Snapea Rice Sticks hit the UK
A new savoury snack brand has launched offering consumers an alternative to fried crisps.
The product, Yushoi Snapea Rice Sticks, is made using green peas and manufactured by Calbee UK, the first European subsidiary of Calbee Inc.
The baked snack is made from green peas and has less than 99 calories per bag or per serving. (more…)
Tuesday, June 30th, 2015, (11:00 am)
Omnichannel guru Jeremy Garlick assembles team of experts for FDIN seminar
As you know the way people buy food nowadays is so very different.
We have such significant growth in discounters, online, convenience and foodservice.
And as you know the large supermarkets have struggled to grow, even though of course they still make up a high proportion of sales – and this should feed into the way we think about NPD. (more…)
Tuesday, June 30th, 2015, (9:13 am)
New soft drink brand Life Tonics launches in the UK
A brand new soft drink is hitting the shelves this month that claims to hydrate, energise and hydrate on the go.
Offering a blend of coconut water and natural fruit extracts, the new Life Tonics range combines original flavours along with fortified minerals and vitamins and an isotonic formulation delivering an original and functional drink.
Formulated with sweetness derived only from natural fruit extracts and natural sweetener Stevia, each bottle only contains 90 calories and is suitable for a Low GI diet. (more…)
Tuesday, June 30th, 2015, (7:02 am)
Free'ist sugar free brand expands range
Free'ist, the Irish specialist in sugar free and no added sugar products, has added new products to its range.
The new range includes a range of confectionary from sugar free popcorn, and breakfast biscuits to marshmallows.
Based in Belfast, the company is hoping to develop into one of the leading innovators in the free-from category. (more…)
Monday, June 29th, 2015, (3:20 pm)
Danio yogurt unveils new #HungerCry campaign
Consumers will be able to express their hunger in a whole new way in a new campaign from danio.
The strained yogurt brand is unleashing a #HungerCry campaign across social media, out of home print ads, video on demand and a will include a stunt.
Designed to target young consumers between 18 and 34, the campaign will hit first on social media with influential viners and Facebookers Arron Crascall, Ben Phillips and Anto Sharp unleashing their individual 'hunger cries'. (more…)
Monday, June 29th, 2015, (1:10 pm)
Fosters unveils new spirit flavoured beer range
Foster's is launching two new spirit flavoured beers – Spiced Rum and Classic Rum – the first flavours in the new 'Foster's Rocks' brand extension, available from August.
Inspired by 19th Century Australian rum traders from New South Wales, who weathered storms to keep the supply of rum flowing, brand owner Heineken hopes Foster's Rocks will continue to drive the lager category, making it more popular amongst 18-24 year olds.
They are available in 440ml cans in packs of four (RRP £4.50) and ten (RRP £11), with the launch supported by a £2m marketing and sampling campaign. (more…)


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Home » Recipes » Steamed Sandesh
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It's a fresh, fun and a deliciously different version of the iconic Bengali sweet. And best of all - without the calories of added sugar!
This recipe is from the book Mithai.
Milk, Sugar substitute sucralose
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Implanted medical devices such as cardiac pacemakers pose a potential hazard in magnetic resonance imaging. Electromagnetic fields have been shown to cause severe radio frequency-induced tissue heating in some cases. Imaging exclusion zones have been proposed as an instrument to reduce patient risk. The purpose of this study was to further assess the impact of the imaging landmark on the risk for unintended implant heating by measuring the radio frequency-induced electric fields in a body phantom under several imaging conditions at 1.5T. The results show that global radio frequency-induced coupling is highest with the torso centered along the superior-inferior direction of the transmit coil. The induced E-fields inside the body shift when changing body positioning, reducing both global and local radio frequency coupling if body and/or conductive implant are moved out from the transmit coil center along the z-direction. Adequate selection of magnetic resonance imaging landmark can significantly reduce potential hazards in patients with implanted medical devices. Magn Reson Med, 2010. (c) 2010 Wiley-Liss, Inc.
Department of Internal Medicine I, University Hospital Würzburg, Julius-Maximilians-University, Würzburg, Germany.
This article was published in the following journal.
Name: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonan
Diffusion Tensor Magnetic Resonance Imaging of Trigeminal Nerves in Relapsing Herpetic Keratouveitis.
Corneal hypoesthesia is the landmark of HSV and VZV keratitis and can lead to neurotrophic keratitis. Diffusion tensor imaging (DTI) is a new magnetic resonance imaging (MRI) derived technique, which ...
Imaging Vascular Disease and Amyloid in the Aging Brain: Implications for Treatment.
Vascular risk factors (e.g. hypertension, dyslipidemia and diabetes) are well known risk factors for Alzheimer' disease. These vascular risk factors lead to vascular brain injuries, which also increas...
Comparative Validity and Reproducibility Study of Various Landmark-Oriented Reference Planes in 3-Dimensional Computed Tomographic Analysis for Patients Receiving Orthognathic Surgery.
Three-dimensional computed tomographic imaging has become popular in clinical evaluation, treatment planning, surgical simulation, and outcome assessment for maxillofacial intervention. The purposes o...
Climate Impacts on Extreme Energy Consumption of Different Types of Buildings.
Exploring changes of building energy consumption and its relationships with climate can provide basis for energy-saving and carbon emission reduction. Heating and cooling energy consumption of differe...
Accounting for biological aggregation in heating and imaging of magnetic nanoparticles.
Aggregation is a known consequence of nanoparticle use in biology and medicine; however, nanoparticle characterization is typically performed under the pretext of well-dispersed, aqueous conditions. H...
St. Mary's Duluth Clinic (SMDC) Pacemaker Magnetic Resonance Imaging (MRI) Study
The purpose of this study is to monitor and follow non-pacemaker dependent patients with implanted permanent pacemakers, who undergo medically required MRI scans. Patients with pacemakers...
The Study of the Impact of Disclosing Imaging Study Information to Trial Participants
The overall goal of the study is to evaluate how research participants in Parkinson Disease studies that include brain imaging with a dopamine transporter ligand choose to receive the imag...
Efficacy of Warming Device During Surgery
This study will test the hypothesis that an electric heating device, the Hot Dog warming system is as effective as the Bair Hugger forced air heating system.
Power Injectable Versus a Non-Power Injectable, Upper Arm, TIVAD for Chemotherapy
Patients with cancer often require intravenous chemotherapy for long periods of time. Ensuring that these patients have safe and reliable access to the veins for chemotherapy is challengi...
A Study to Determine the Safety and Efficacy of a New Non-Invasive Heating Garment to Reduce Urinary Hesitancy
To determine the safety and efficacy of the ThermaRx heating device for the application of controlled low level heat to improve symptoms of LUT dysfunction (hesitancy, urgency).
Molecular Imaging
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.
Risk Sharing, Financial
Any system which allows payors to share some of the financial risk associated with a particular patient population with providers. Providers agree to adhere to fixed fee schedules in exchange for an increase in their payor base and a chance to benefit from cost containment measures. Common risk-sharing methods are prospective payment schedules (PROSPECTIVE PAYMENT SYSTEM), capitation (CAPITATION FEES), diagnosis-related fees (DIAGNOSIS-RELATED GROUPS), and pre-negotiated fees.
Ablation Techniques
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Hot Dogs
From bacon-wrapped hot dogs with avocado to hot dogs topped with cheddar and sautéed apples, here are terrific hot dogs.
Pastrami-and-Mushroom "Hot Dogs"
More ∨
In this distinctive high-low recipe, Joe Beef co-chef and co-owner Frédéric Morin wanted to combine girolles (chanterelle mushrooms) with something less highbrow. "As a good chef, you can't mix all expensive things in one dish," he says. So he stuffed the mushrooms inside hot dog buns with Montreal's famous smoked meat.


text:
Xi-Cheng Zhang, Editor-in-Chief
Ying Wang, D. N. Wang, C. R. Liao, Tianyi Hu, Jiangtao Guo, and Huifeng Wei
Ying Wang,1,2 D. N. Wang,1,* C. R. Liao,1 Tianyi Hu,1 Jiangtao Guo,3 and Huifeng Wei3
1Department of Electrical Engineering, The Hong Kong Polytechnic University, Hong Kong, China
2Laboratory of Optical Information Technology and School of Science, Wuhan Institute of Technology, Wuhan 430073, China
3State Key Laboratory of Optical Fiber and Cable Manufacture Technology, Yangtze Optical Fibre and Cable Company Ltd. R&D center, Wuhan 430073, China
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Keep up to date with the latest news and content from BMC Women's Health and BioMed Central.
Eva R Groenewoud*, Nick S Macklon, Ben J Cohlen and on behalf of the ANTARCTICA trial study group
Corresponding author: Eva R Groenewoud email@example.com
BMC Women's Health 2012, 12:27
© 2015
BioMed Central Ltd unless otherwise stated. Part of Springer Science+Business Media.


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Back to Previous Page
The Boss 302 returns to the road after 42 years.
Shaking Hands With The Devil
Watch as a Cobra Jet lines up with a Super Cobra Jet!
Make Your "Five-Oh" Go Faster and Smoother
If you love Ford performance, this is the place for you!
We put together some of our favorite articles about the Ford Mustang!
King of the Road
A Race Car For The Streets
Born on California's highways, the Mustang SSP offered police a high-performance alternative.
How to get up-close and personal to find the finest Ford Mustang you can afford.
A visual guide to telling one vintage Pony Car from its model-year stable mates.
Mustang's third body style emerges.
A visual feast for Mustang lovers.
A Real Jekyll & Hyde Ride
Upgrading a 1966 Mustang's Baer system from two-piston PBR caliper to six-piston Baer caliper.
A fitting end to the S-197 Mustang era.
Daytona Speedway was a fitting corral for these ponies.
Tulsa Raceway Park thundered with Ford power!
Carving corners with Ford power!
Walking around the paddock at Hallett Motor Racing Circuit
The Ultimate Ford Family Reunion
Fords invade downtown Tulsa's Brady Arts District
Walking around Tulsa Raceway Park
The capstone of a great event.
Families, fun and Mustangs at Myrtle Beach.
Sometimes an auction is also a car show.
A highway with history.
One great feature of the show was the constant parade of amazing iron rolling down the streets.
Classic F-Bodies Storm Las Vegas
This year featured an amazing assortment of vintage Ducatis.
A time honored tradition in the rodding world.
While function trumps form in the racing world, there is no denying the beauty of a well engineered racing machine.
These engines are just as exquisite as the bodies that surround them.
Checking out the local flavor in north metro Atlanta.
Big, round fenders set these rides apart from their skinny cousins.
It isn't very often that an attraction exceeds expectations by leaps and bounds, but the NASCAR Hall of Fame does so at every turn.
Fat fenders, no fenders, they were all here!
A fitting finale for an amazing Ford filled event!
This year there was a bumper crop of great trucks.
The Turkey Run is back for a second helping!
Hailing from Europe and Asia these rides bring a little bit of home with them.
These kids show what the next generation can do!
Magnificent examples of living automotive history!
The Bruce Weiner Microcar Museum auction by RM Auctions featured some interesting finds, like this mini-Jeep clone!
The Spirit of Ecstasy was well represented at the 2010 concours.
The name of the show may be "Back To The 50's" but these 60's cars are welcomed with open arms.
These builders went "all in" on their designs and it shows!
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Music to Your Ears
Sonic Reducer
By Jessica Cassyle Carr
Constantines Tournament Of Hearts (Sub Pop)
Show Up!
Matisyahu in tha Bayiiiiit!
Or, Matisyahu in tha houuuuse!
By Laura Marrich
Blackalicious Takes Us to School
Uh, it's embarrassingly obvious here how little I know about hip-hop. Hey, don't blame a girl for trying.
By Jessica Cassyle Carr
Flyer on the Wall
Pontius Violet; Friday, Sept. 23, Puccini's Golden West Saloon. 21-and-older.
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Jimmy Thackery • blues at Low Spirits
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Ancient Aliens
View Single Post
November 9 2012, 01:45 AM
Vice Admiral
Location: NJ, USA
Re: Ancient Aliens
newtype_alpha wrote:
RAMA wrote:
newtype_alpha wrote:
What is it about theoretical physicist/cosmologists that leads them to believe they are in any way qualified to speculate about subjects totally unrelated to their area of expertise?
A book about theoretical evolutionary paradigms, written by a physicist. It should be about as useful as a book on high energy particle physics written by an archeologist.
As I pointedd out in other threads it hass been far more common in the last 3 to 4 decades for scientists to comment on interdisciplinary topics than ever before, partly because of convergence on many subjects (biology is in fact related to physics and planetary science)
No they don't. Biologists do not comment on matters of physics OR planetary science for the same reason archeologists don't comment on economics or psychology; the only reason the REVERSE is true is because members of the latter discipline are used to people respecting them as Really Smart People and never questioning the validity of their claims.
People ASSUME those fields have a certain overlap, but this is only true on the purely superficial/philosophical level where science fiction writers generally operate. The actual study of theoretical physics and evolutionary biology are so fundamentally different and involve such hugely different data sets that the experts in either field know almost nothing of consequence about the other (or else they would be experts in BOTH disciplines, which no human really has time for).
and because science has been popularized in general by some writers outside their disciple, Asimov and Sagan pretty much got the ball rolling there...
Yes, because they were science fiction writers. Sci-fi writers don't HAVE to know what they're talking about, they just have to
like they do, and that's easier to do if you have an actual science background.
Physicists need to get over themselves and realize that a doctorate in theoretical physics isn't a license to make shit up and have people believe you.
As for Davies, if you'll note he also an astrobiologist.
Of course he is. And I'm a professional dragon slayer.
Again you are wrong, in fact they DO
on such things, they just simply are not working in that particular field. I've read more than enough articles on books from such scientists to know you are completely wrong. Yes, there are sci-fi authors who fit the description, but I'm not talking about those or their fiction.
Not to put too fine a point on it, but many scientists these days also are part of groups outside their chosen field, Davies in particular started one that I linked to which does more than pure science or theoretical research, but speculates on lots of big questions through the gamut of science, and I see no problems with gathering intellectual thought into such speculations, and in that spirit, Davies wrote his book and validly so.
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£720 pw
2 bedroom serviced apartment to rent Moor Court, Westfield,Gosforth,Newcastle Upon Tyne,NE3This spacious, south facing, bright 2 bedroom 2nd floor apartment is situated within an Art Deco style mansion block and is furnished to the highest standards. Available for short term let from 2 nights onwards. The price quoted is for stays for one week or more. More details ›
Reduced on 20/03/2015 by Week 2 Week Serviced Apartments Ltd, Newcastle-Upon-Tyne. Call: 0191 687 0576 Local call rate
£720 pw
2 bedroom serviced apartment to rent West Avenue, Gosforth, Newcastle Upon Tyne, NE3Large, airy 2bed 2 bath apartment across second floor in a converted Victorian terrace with on street parking More details ›
Added on 16/03/2015 by Week 2 Week Serviced Apartments Ltd, Newcastle-Upon-Tyne. Call: 0191 687 0576 Local call rate
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3 bedroom town house to rent Lanesborough Court,Gosforth,Newcastle Upon Tyne,NE3A top quality 3 bedroom fully furnished & equipped Town House on the secure residential Lanesborough Court development, in Gosforth. Close to the local schools, shops, bus routes and City centre, Kingston Park shopping mall, Airport & A1M. Available from August 15th, 2015 to June 30th 2016 More details ›
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text:
Gunmetal Black Ep 01
episode 14.26 / 5.00 5,087 Views
Lucina's First Day
A look at the first day of Lucina in Super Smash4.24 / 5.00 16,839 Views
BATMAN v SUPERMAN final showdown
SPOILERS!!4.19 / 5.00 14,800 Views
yea Fck pussies that are offended by this! if they dont like then dont watch it cuz if u didnt know it was going to be gory then u should read the titel 1st. Make more =) MOAR GORE MOAR GORE MOAR GORE i liked ure madness day tribute too. >=)
>=D MOAR GORE MOAR GORE MOAR GORE MOAR GORE MOAR GORE ok im done =) MAKE MORE! hey that rhymes
more gore for shizzle!
It's good to see something gruesome every once in a while to desensetize yourself of scary n gross things, and this is about as gruesome as it gets. Good job!
that is some fucked up shit...
w00t ! ! !
wow awsome blood effects i love it just like i wanted to see and easter egg stage is wonderful too i've lost my words it was just kewl great work u are the master of blood&gore
Wow thanks!


text:
Bush's War on the Press
All Presidents try to keep secrets; it comes with the job description. Following 9/11, the need for secrecy increased significantly. Bush, however, has taken advantage of this new environment to shut down the natural flow of information between the governing and the governed in ways that have little or nothing to do with the terrorist threat. As Charles Lewis of the Center for Public Integrity points out, "The country has seen a historic, regressive shift in public accountability. Open-records laws nationwide have been rolled back more than 300 times--all in the name of national security." Federation of American Scientists secrecy specialist Steven Aftergood adds, "Since President George W. Bush entered office, the pace of classification activity has increased by 75 percent.... His Information Security Oversight Office oversees the classification system and recorded a rise from 9 million classification actions in fiscal year 2001 to 16 million in fiscal year 2004."
Some of these efforts may be justified as prudent preparation in the face of genuine threats, but this is hard to credit, given the contempt the Administration has demonstrated for the public's right to information in non-security-related matters. Upon entering office, Bush attempted to shield his Texas gubernatorial records by shuttling them into his father's presidential library. That was followed by an executive fiat designed to hide his father's presidential records, as well as those of the Reagan/Bush Administration, by blocking the scheduled release of documents under the Presidential Records Act of 1978 and issuing a replacement presidential order that allowed not only Presidents but also their wives and children to keep their records secret. (The records had already been scrubbed for national security implications.)
In the aftermath of 9/11, Administration efforts to prevent accountability accelerated to warp speed. Attorney General Ashcroft reversed a Clinton Administration-issued policy governing FOIA requests that allowed documents to be withheld only when "foreseeable harm" would likely result, to one in which merely a "sound legal basis" could be found. And that was just the beginning. Even when documents were not withheld de jure, Administration officials often withheld them de facto. When People for the American Way sought documents on prisoners' cases being litigated in secret, the Justice Department required it to pay $373,000 in search fees before officials would even look. "It's become much, much harder to get responses to FOIA requests, and it's taking much, much longer," David Schulz, the attorney who helps the Associated Press with FOIA requests, explained to a reporter. "Agencies seem to view their role as coming up with techniques to keep information secret rather than the other way around. That's completely contrary to the goal of the act."
In addition, as Aftergood notes, "an even more aggressive form of government information control has gone unenumerated and often unrecognized in the Bush era, as government agencies have restricted access to unclassified information in libraries, archives, websites and official databases." These sources were once freely available but are now being withdrawn from view under the classification "sensitive but unclassified" or "for official use only." They include: the Pentagon telephone directory, the Los Alamos technical report library, historical records at the National Archives and the Energy Department intelligence budget, among many others. Even more alarming is the web of secrecy surrounding the operations of what has become the equivalent of a police state at Guantánamo Bay and other military prisons around the world, where the accused are routinely denied due process and traditional rules of evidence are deemed irrelevant. Exactly two members of Congress, both sworn to secrecy, are being briefed by the CIA on these programs. The rest of Congress, the media and the public are given no information to judge the legality, morality or effectiveness of these extralegal machinations, some of which have already resulted in officially sanctioned torture and possibly even murder.


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Skiing Newbie? Time to Head to Tahoe
We all have to start somewhere, so if you're looking to take those first tentative steps to become a snowboarder or skier, a half-dozen winter resorts in the Truckee-North Lake Tahoe area are once again giving newbies the chance at a very reasonable rate.
Lunafest 2011 Comes to Tahoe
Lunafest, a travelling festival turned fundraiser featuring short films by, for and about women, makes its annual appearance at Squaw Valley on Thursday, December, 8.
Celebrate Post-Thanksgiving with a Holiday Jazz Festival This Weekend in Tahoe
Looking for something smooth to take the edge off the beginning of the holiday season?
Then head over to Incline Village this weekend for the annual Holiday Jazz Festival at the Hyatt Lake Tahoe.
Jonny Moseley's Favorite Hangouts
Jonny Moseley may have made his name in the steeps and deeps of Squaw Valley, but in his heart he's a city boy.
And that city is San Francisco.
Get Some Rest and Rejuvenation in the Tahoe This Weekend
Although the waters of Lake Tahoe aren't strictly restorative, folks from the City have been traveling to the Big Blue for generations in seeking solace from the hassles of day-to-day urban life.
Come Friday, you can head up to Tahoe for a little R&R and perhaps get some health concerns cleared up in the bargain as Granlibakken Lodge plays host to the annual Women's Wellness Weekend in Tahoe City.
Snow, Beer and Wine Junkies Collide at This Weekend's SnowBomb Ski & Snowboard Festival
The calendar says winter is still a couple of months off, but it's not too early to get ready for the approaching ski and snowboard season.
And one good way to get a jump on snow time is head over to Fort Mason in San Francisco this weekend for the fourth iteration of the SnowBomb Ski and Snowboard Festival.
Got Your Ski Lease Yet? Better Hurry Up
The great thing about having Lake Tahoe in San Francisco's backyard is that the winter mountain resorts are a little more than a three-hour drive from the city.
The bad thing is that it's a three-hour drive to the lifts.
Tahoe's Northstar Changes Its Name
Goodbye Tahoe. Hello California.
That's the track Northstar resort is taking after the recent decision to make an adjustment to its moniker.
"There was a massive line of debate on whether we should make the change," said Bill Rock, the resort's chief operating officer. "But (the change) is a statement of where the brand is going."
So, instead of going to Northstar-at-Tahoe, a popular Truckee-area destination for San Francisco snowsports enthusiasts since its opening in 1972, skiers and snowboarders will now be making tracks at Northstar California (that little star logo seen around the resort has been tweaked a bit as well).
Wellness Amongst The Wilderness at Tahoe's Wellness Weekend, October 21-23
Tahoe is intrinsically relaxing: mountain air, lake views, mellow townies, and countless activities to satiate an athletic appetite. Whether an avid skier or river floater, most people leave Tahoe with an overall feeling of greatness. Tahoe is also an ideal retreat for gaining wellness while lapping in luxury. The 4th annual Lake Tahoe Wellness Weekend at the Hyatt Regency Lake Tahoe Resort, Spa & Casino offers an all-inclusive two days packed with fitness and healthy living classes and seminars at an alpine oasis.
Escape to South Lake This Fall with Embassy Suites Lake Tahoe
With Tahoe just a breath away from the Bay Area, it's easy to pop over for a long weekend of relaxation. The icing on the cake? A luxurious place to stay tucked in the mountains bathed in gorgeous fall colors on the shores of South Lake and minutes away from all the action. You can get that at Embassy Suites Lake Tahoe, which offers a ton of travel packages so visitors can immerse themselves in the beauty of Tahoe and tailor their stays to their moods.


text:
Contact Us
The PNREC 2015 Conference Co-chairs are Hart Hodges and James McCafferty of Western Washington University. To propose a session or submit a paper, contact the conference co-chairs by email at: firstname.lastname@example.com.
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Java basic tutorial
At least since the first edition of Kernighan and Ritchie's The C Programming Language it's been customary to begin programming tutorials and classes with the "Hello World" program, a program that prints the string "Hello World" to the display. Being heavily influenced by Kernighan and Ritchie and not ones to defy tradition we begin similarly.
[B]Java Tutorial 5 – Arrays[/B]
In non-trivial computing problems you often need to store lists of items. Often these items can be specified sequentially and referred to by their position in the list. Sometimes this ordering is natural as in a list of the first ten people to arrive at a sale. The first person would be item one in the list, the second person to arrive would be item two, and so on. Other times the ordering doesn't really mean anything such as in the ram configuration problem of the previous chapter where having a 4 MB SIMM in slot A and an 8 MB SIMM in slot B was effectively the same as an 8 MB SIMM in slot A and a 4 MB SIMM in slot B. However it's still convenient to be able to assign each item a unique number and enumerate all the items in a list by counting out the numbers.
Message was edited by: elitehussar
[B]Java Tutorial 4 – Methods[/B]
All the programs we've written to date have been quite simple, well under fifty lines of code each. As programs grow in size it begins to make sense to break them into parts. Each part can perform a particular calculation and possibly return a value. This is especially useful when the calculation needs to be repeated at several different places in the program. It also helps to define a clearer picture of the flow of the program, much like an outline shows the flow of a book.
[b]Java Tutorial 3 – The For Statement and Operators[/b]
Java isn't as redundant as perl, but there's still almost always more than one way to write any given program. The following program produces identical output to the Fahrenheit to Celsius program in the preceding section. The main difference is the for loop instead of a while loop.
[b]Java Tutorial 2 – Classes and Objects: A First Look[/b]
Classes are the single most important feature of Java. Everything in Java is either a class, a part of a class, or describes how a class behaves. Although classes will be covered in great detail in section four, they are so fundamental to an understanding of Java programs that a brief introduction is going to be given here.


text:
Some of the jobs that Franky did after college include a bouncer at a strip club, security guard and as a construction worker.
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"I love how pretty and classy these notes and labels are. The print on the invitation and label is a bit small but easily remedied with increase in font size."
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text:
Suzuki Grand Vitara Problem Report
Suzuki Grand Vitara AC not Blowing Cold Air Due to Failed AC Condenser Fan Motor
(57 reports)
The AC condenser fan motor may fail. If this occurs the air conditioning will stop blowing cold air.
AC is not cold anymore,air is blowing, but the don't hear the compressor turn on, also I notice on the Fan Speed Knob, the Close Circulation Indicator light is now BLINKING, taking it in tomorrow for service with the dealer! Anybody experience this? - Tbor3664GU
16 people like this
The A/C fan does not work. You hear the compresson starting on the engine when powered on, but no air coming out. - Visitor
6 people like this
My blower motor Quit working. A friend took it out. Blew it out with an air compressor and tapped it with a hammer. He said that bearing was stiff. Replaced it and it starting working again. Thankfully it was going to cost me about $600 to fix it. - Owen79
5 people like this
The a/c would not blow cold air. The condensor had to be replaced. - Visitor
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Fan was intermittent then quit. - Visitor
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Blows like its on high all the time. Does not blow cold air. - Visitor
2 people like this
A/c stopped blowing cold air and steering became stiff. Since the same belt is connected to both a/c compressor and power steering, when the compressor went it effected the steering. Had to have compressor replaced - Visitor
1 person likes this
no cold air thought it might be low on freon so I check it was low but still should of had cool air so I added some and still not blowing cold air. - Visitor
1 person likes this
Fan not blowing Cold air anymore. - Visitor
air not blowing cold - Visitor
Ac blower would not come on. Kicked under glove compartment and it would come on. Then removed it cleaned and lubed inside and worked like a charm. Just repeated again 2 Years later. I live I'm Florida and use AC everyday of the year. - Visitor
A/C and defroster not blowing. - Visitor
Air not getting cold - screaming4advice
AC not blowing cold air anymore, heat is working however. - Visitor
Blown ac fuses 10 minutes after replacement, blowing hot air - Visitor
hot air clows out then power stering went since its connected to the compressor i was told i need a new compressor and its a 1500 job - Visitor
bought another one still didnt fix problem. - Visitor
the fan will come on but will only blow out hot air. - Visitor
replace condenser - Andreandonna
a/c stopped working already 2nd time - Visitor
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text:
Lithuanian Strawberry Torte
|1 3⁄4 Cup (28 tbs)
|1 Cup (16 tbs)
|Egg yolks
|Cake flour
|2 Cup (32 tbs), sifted
|Baking powder
|1⁄2 Teaspoon
|Egg whites
|Whipping cream
|3 Cup (48 tbs)
|1 Teaspoon
|Currant jelly
|1⁄2 Cup (8 tbs)
|Coarsely chopped pecans
|1 Cup (16 tbs)
|Strawberry preserves
|1⁄2 Cup (8 tbs)
In large mixing bowl cream together 1 1/4 cups of the sugar and the butter till very light and fluffy.
Add egg yolks, one at a time, beating well after each; continue beating till very fluffy, about 5 minutes.
Sift together flour, baking powder, and 1/2 teaspoon salt; stir into creamed mixture.
Beat egg whites till soft peaks form; gradually add remaining 1/2 cup sugar, beating to stiff peaks.
Fold into creamed mixture.
Pour into 3 lightly greased and floured 9x1 1/2-inch round baking pans.
Bake at 350° till done, about 20 minutes.
Cool 10 minutes; remove from pans.
Cool on rack.
Whip cream and vanilla just to soft peaks.
Place a cake layer on serving plate.
Spread with currant jelly and then with 1 cup of the whipped cream.
Sprinkle with 2 tablespoons pecans.
Spread second layer with 1/3 cup of the strawberry preserves, then with 1 cup of the whipped cream; sprinkle with 2 tablespoons pecans.
Gently place atop first layer.
Carefully top with third layer.
Frost top and sides with remaining whipped cream; coat sides with remaining pecans.
Using tip of a small spoon, dot top with remaining strawberry preserves.


text:
Cartel Land
The film provides a fascinating, on-the-ground account of people struggling with situations that range from challenging to horrific.
The film provides a fascinating, on-the-ground account of people struggling with situations that range from challenging to horrific.
"Stray Dog" largely succeeds because Granik's technique complements her subject. Both he and the film are modest in their goals and cherish the value of…
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
Nick Allen picks one of his favorite Roger reviews.
An excerpt of Tony Fitzpatrick's column, "Dime Stories," which has its first published compilation in stores this month.
Nick Allen picks one of his favorite Roger reviews.
An excerpt of Tony Fitzpatrick's column, "Dime Stories," which has its first published compilation in stores this month.
A review of Han Gong-ju from a Far Flung Correspondent.
An FFC responds to Kyle Smith's assertion that women can't enjoy GoodFellas.
Ta-Nehisi Coates writes letter to his son; Robert Frank: the man who saw America; Pizzolatto vs. Fukunaga; Scorsese on "The Third Man"; Dietrich Brüggemann on…
Ramin Bahrani's first documentary short, including an interview with the director.
Intimate and impressionistic but ultimately a little self-indulgent, the documentary "Elena" explores the transcendent nature of the sisterly bond.
Fusing memory and mystery, director and narrator Petra Costa traces the fate of her older sister, actress Elena Andrade, through the prism of her own childhood. Actually, calling it a documentary isn't entirely accurate. It's more of a dreamlike mix of artful images and sounds: decades-old archival footage, snippets of audio diaries and newer images shot in modern-day Manhattan. The challenging way it traverses genres and toys with reality is reminiscent of Sarah Polley's excellent (and superior) documentary "Stories We Tell."
Costa was just seven years old when Elena, who was 13 years her senior, left the family's home in Sao Paolo, Brazil, with dreams of becoming an actress in New York City. But home movies from Costa's infancy in the early 1980s reveal a powerful connection between the two. There's Elena cradling Costa, twirling her around the living room, singing with her in the bathtub. There they are sharing a tender kiss before lying down together for a nap. The age difference seems to have made Elena an influential force as both a mother and sister figure.
But Elena, who achieved some fame as a dancer and stage actress in her native city—one who was notorious for her obsessive rehearsal habits—wasn't satisfied with just that. She wanted to be a film star in the United States. And she inspired in Costa the same drive to perform.
"You showed me all the Shirley Temple movies and trained me to become an actress," Costa intones as part of the film's pervasive voiceover. Her narration may almost be too breathy, too hypnotic. It lulls us when the movie's tension should be building.
"Elena" isn't just a reflection on the power of the sibling connection but also an investigation into what happened to Costa's sister once she set out in search of her dreams. It's clear early on that this radiant woman with the deep-set eyes, bright smile and great potential became the victim of a tragic undoing; the way Costa and her mother speak of Elena reveals great longing and loss.
But Costa, who herself ventured to New York to study acting at Columbia University in 2003, also attempts to reconstruct her sister's past, ostensibly in the hopes of achieving some closure. This consists of her wandering around the city, everywhere from the Upper West Side to Times Square to the Williamsburg Bridge, musing on their shared history. Costa also blends in extensive audio recordings Elena made—her version of a diary—in poetic Portuguese.
Headlights from passing cars provide blips and blurs. We see reflections in taxicab windows, a hand, a smile, gauzy wisps of sunlight. The camera follows her as she walks down street after street, passing her fellow pedestrians as the wind whips her hair. Costa creates a palpable sense of alienation within this crowded city. But she's also too fond of some pretty obvious Ophelia imagery as a metaphor for her sister's fate, repeatedly showing us young women floating in water in diaphanous dresses.
The cumulative effect calls to mind a music video that probably seemed pretty artsy in the '80s. The repetitive and prolonged nature of these scenes almost seems like padding toward the end, despite the film's relatively brief running time. What began in beautiful, intriguing fashion ends up feeling surprisingly dull. It also reveals how deeply insular Costa's tale is. The sisters' stories begin to overlap and blur in a way that's meant to be profound, but, ultimately, both women remain elusive.
A rebuttal to Joni Edelman's piece on "Inside Out."
This message came to me from a reader named Peter Svensland. He and a fr...
The July 2015 edition of The Unloved looks at Andrew Dominik's "The Assassination of Jesse James by the Coward Robert...
On the look and sound of "The Third Man."


text:
It's been a good year for Brad Pitt, between his well-regarded turn in Tree of Life and lead performance in Moneyball, the latter of which has been generating Oscar buzz for a while now. His future is looking pretty bright too, with parts in upcoming noteworthy titles like Andrew Dominik's Cogan's Trade, Marc Forster's World War Z adaptation, and Steve McQueen's Twelve Years a Slave.
However, the end is apparently drawing near for Pitt the performer, seeing how the man has tentative plans to hang up his acting hat in about three years (from the time of writing this).
The actor later released the following statement at a South Korean press conference, in order to further clarify his intentions:
"I wasn't actually putting an exact deadline on my expiration date [in Australia's "60 Minutes" interview], but I see it coming. I just have other interests and I do quite enjoy the production side."
When you look at Pitt's film acting resume, it's a pretty impressive list that encompass famous titles like Thelma & Louise, A River Runs Through It, True Romance, Interview with the Vampire, Legends of the Fall, Se7en, Twelve Monkeys, Fight Club, Snatch, Ocean's Eleven, Mr. and Mrs. Smith, Babel, The Assassination of Jesse James by the Coward Robert Ford, The Curious Case of Benjamin Button, and Inglourious Basterds, alongside the aforementioned Pitt-starring vehicles.
That's all to say: the man has led an overall excellent and eclectic career. So, if Pitt does decide to actually call it quits on acting and instead just stick to producing (and probably directing) movies sometime in the new few years, then at least he'll end things on a high note.
Source: Deadline, The Daily Telegraph


text:
I have two
UITextFields that I want to use for logging in, one for the username and one for the password. Before I wasn't able to dismiss the keyboard in the first
UITextField but I managed to fix that, the problem now is that once it dismisses I cannot click on the other
UITextField to enter in the password, I am just stuck in the username
UITextField with the keyboard dismissed, so especially I can't do anything. Any suggestions on how to dismiss the keyboard and then click on the other
UITextField to enter the information?
@interface LoginViewController () <UITextFieldDelegate>
@implementation LoginViewController
@synthesize managedObjectContext, usernameField, passwordField;
-(void) textFieldDidEndEditing:(UITextField *)textField{
-(void) textFieldDidBeginEditing:(UITextField *)textField{
[self.usernameField becomeFirstResponder];
- (BOOL)textFieldShouldReturn:(UITextField *)textField{
//error occurs here
[self.usernameField resignFirstResponder];
return YES;


text:
Possible Answer
Celebrity Measurements Of Stars: Nicole Murphy measurements provide human height statistics through Leonardo da Vincis Vitruvian Man. StarNoStar human height ... - read more
Welcome to Star No Stars Nicole Murphy biography profile. Nicole Murphy is a Personality from Sacramento California United States. Nicole Murphy is 47 years old, born ... - read more
Please vote if the answer you were given helped you or not, thats the best way to improve our algorithm. You can also submit an answer or search documents about nicole murphy body measurements.


text:
Tampa, FLUSA
October 30, 2013
No introduction yet
About us…
Help support your Meetup
We are advocating the public to register to vote, request absentee ballots in order to get medical marijuana legal in Florida. This statewide effort has eight meetup groups around the state to help support the overall goal of getting the laws changed. In addition to offering information on absentee voting requests, we are writing our legislators, and raising funds to support the effort. Come meet like minded individuals and learn the best ways to take action. For more information, please visit our website www.pufmm.org - People United for Medical Marijuana, a PAC registered with the Florida Division of Elections.
381 Photography Fans
725 Artists and Art Lovers
937 Players
620 Play Explorers
946 Bicyclists
3,049 Members
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


text:
All hotels in Vancouver, British Columbia, Canada
1 room, 2 adults
1150 Denman Street, Vancouver, BC, V6G 2M9, Canada, 800-491-6126
English Bay Hotel, Vancouver
Lowest price$91
available on 07/07/15
Best Price Guarantee
Guestrooms with kitchenettes, near Stanley Park
- Free WiFi
Main amenities
- 52 smoke-free guestrooms
- Near the beach
- Self parking
- 24-hour front desk
- Coffee/tea in the lobby
- Daily housekeeping
- Computer station
- Front desk safe
- Self-serve laundry
- Multilingual staff
- Luggage storage
- Tour/ticket assistance
What's around
- In Downtown Vancouver
- Stanley Park (1.1 mi / 1.7 km)
- Vancouver Aquarium (1.2 mi / 2 km)
- Vancouver Convention Centre (1.4 mi / 2.2 km)
- BC Place Stadium (1.8 mi / 2.9 km)
- Rogers Arena (2.1 mi / 3.3 km)
i wouldn't recommend this motel because it was unclean and the room was crowded. No air…
Being above restaurants leaves a food smell in the hotel. Carpet is sticky. Love the…
TripAdvisor Traveller Rating: 3
From 100 reviews
Enter dates to check prices
Hotel Info: 866-539-8117from $91
- Quadruple Room
- Triple Room
- Suite, 1 Bedroom
- Double Room
- Single Room
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 52 rooms
- This hotel is arranged over 4 floors
- 24-hour check-in
- Check-out time is 11 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 19
Travelling with others
- Up to 2 children (12 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Pets not allowed (service dogs only)
- Free wired Internet access in public areas
- Free WiFi and wired Internet access in rooms
- Self parking *
Other information
- Smoke-free property
Nearby Two Star Vancouver hotels
In the hotel
Food and drink
- Coffee/tea in the lobby
Things to do
- Bicycle rentals nearby
- Golfing nearby
Working away
- Computer station
- 24-hour front desk
- Tours/ticket assistance
- Laundry facilities
- Luggage storage
- Number of buildings/towers - 1
- Elevator/lift
- Safe-deposit box at front desk
In the room
Home comforts
- Coffee/tea maker
Sleep well
- Blackout drapes/curtains
- Pillowtop mattress
Freshen up
- Private bathroom
- Shower/tub combination
- Hair dryer
Be entertained
- Premium TV channels
Stay connected
- Desk
- Free WiFi
- Phone
Food and drink
- Refrigerator
- Microwave
- Kitchenette
- Stovetop
- Cookware, dishware, and utensils
- Daily housekeeping
Top Vancouver hotels
Recently reviewed hotels in Vancouver
- Holiday Inn Hotel & Suites Vancouver DowntownFrom
"Great location in the heart of Vancouver with onsite parking. Easy walk to Pacific Centre area and Yaletown. Nicely maintained property. We had a cozy corner room that seemed to…"Jun 22, 2015
- Best Western Plus Kings Inn & Conference CentreFrom
"Older but well maintained property in busy commercial area convenient to shops and restaurants. Room was comfortable and spacious. The only snafu was breakfast which was served in…"Jun 22, 2015
- Kingston Hotel Bed & BreakfastFrom
"The room was small and cozy, but it was a nice little hideaway, and right in the middle of downtown Vancouver (where there's *plenty* to see and do!). I missed having my own…"Jun 22, 2015
- Granville Island HotelFrom
"The room was beautiful but a bit cramped. We had a balcony room with an amazing view of the water, but both of us could barely fit on it. The staff was very helpful and we loved…"Jun 22, 2015
Nearby hotels
English Bay Hotel, Vancouver's small print
Also known as
- English Bay Hotel
- English Bay Hotel Vancouver
- English Bay Vancouver
- Hotel English Bay
Parking height restrictions apply.
Optional extras
Self parking costs CAD 10.00 per night with in/out privileges
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
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The transportation coordinator works to optimize the transportation and suppliers network for their organization. Their main objective is to ensure that all incoming and outgoing deliveries are made on time. Transportation coordinators must be careful to comply with all government rules and regulations regarding the transportation of goods and materials. They maintain delivery schedules and tracking deliveries, as well as provide tracking information to customers and internal departments as needed. Transportation coordinators also report on any issues or delays in product shipment. Additionally, these coordinators may also research and negotiate delivery costs to develop more cost-effective shipping methods. They also handles customer complaints regarding late or damaged shipments.Read More...
The day-to-day responsibilities of a transportation coordinator include packaging and securing all products for shipping, contacting shipping carriers to arrange pickup times, communicating delivery schedules to customers and internal contacts, and monitoring shipments to ensure that deliveries are made safely and in a timely manner. Individuals in this position works with employees in many different departments including production, engineering, purchasing, sales, and marketing. The transportation coordinator typically reports to the operations, logistics, or supply chain manager, and the hours of this position vary depending on the needs of their employer.
A high school diploma or equivalent is generally the minimum educational requirement for this position. Previous experience in shipping and receiving is preferred. Transportation coordinators must be able to stand and walk for long periods of time and lift up to 50 pounds.
Transportation Coordinators report using a diverse set of skills on the job. Most notably, skills in Oral / Verbal Communication, SAP Transportation Management, Logistics, and Microsoft Excel are correlated to pay that is above average. Skills that seem to negatively impact pay include Customer Service and Scheduling. It is often found that people who know Logistics are also skilled in Microsoft Excel.
Median of all compensation (including tips, bonus, and overtime) by years of experience.
Transportation Coordinators with a lot of experience do not necessarily enjoy more money. Respondents with less than five years' experience take home $35K on average. In contrast, those who have been around for five to 10 years earn a noticeably higher average of $40K. Transportation Coordinators who work for 10 to 20 years in their occupation tend to earn about $41K. Veterans who have worked for more than two decades do tend to make the most in the end; the median pay for this group is $46K.
|Extremely satisfied
Rated 5 out of 5
based on 116 votes.
57 %
43 %
|Medical: 80%
|Dental: 70%
|Vision: 56%
|None: 18%


text:
I sent your Alaska King Crab Leg Dinner to a friend for his birthday, and he was
VERY impressed. The dinner for two was actually enough for all three people in
his family.... more
Our chocolate covered Maine Blueberries and Cranberries are a delicious way to complete any meal.
The Berries are dipped in milk chocolate by a local chocolate maker and packaged in 3 oz. servings for a perfect gourmet treat!


text:
Petr Simecek
Biostatistician, Institute of Molecular Genetics of the ASCR
Prague, Czech Republic
About Petr
An idea worth spreading
The human brain is a delusion generator.
I'm passionate about
brilliant ideas, stupid people, slow running, meaning of life
Talk to me about
How to make the world a better place to live.
People don't know I'm good at
My TED story
My friend, Radek Pelanek, told me about TED during the high school reunion. I saw a couple of videos and I was totally amazed. I stopped watching news in the evenings and started watching TED instead.


text:
Sathya Sai schemes will continue unhinderedTrustee of the Sri Sathya Sai Central Trust, Puttaparthi, R.J. Ratnakar, said on Thursday that the public service schemes initiated by the Baba would continue unhindered. Addressing a press conference on his maiden visit to the city, he said that ... The Hindu, 1 month ago
Facilities to be upgraded - The Hindu, 1 month ago
1 images for "puttaparthi"
Handri Neeva within stipulated time: CM
Comment · print · T T T+· T- Chief Minister N. Chandrababu Naidu on Friday vowed to complete the Handri Neeva Sujala Sravanthi (HNSS) project within the stipulated time. During his whirlwind tour of the HNSS project area in Anantapur ...The Hindu, 3 days ago
CM to Visit Anantapur, Kadapa Today
TIRUPATI:CM N Chandrababu Naidu will visit Anantapur and Kadapa districts on Friday. At around 9.55 am, Naidu would reach Puttaparthy airport by special aircraft from Gannavaram airport. He will reach Jeedipalli reservoir of Beluguppa mandal by ...New Indian Express, 4 days ago
11 arrested for plotting murder of four persons
Comment · print · T T T+· T- ýThe Anantapur Police on Saturday arrested 11 persons on charges of plotting the murder of four persons in Anantapur and Chittoor districts. Anantapur Additional Superintendent of Police Malyadri told the ...The Hindu, 1 week ago
KSRTC plans to add Scania to its luxury fleet
Thiruvananthapuram: The KSRTC has started evaluating the Swedish major's Scania buses to make its luxury services more cost-effective. If an ongoing road evaluation test goes in its favour, Scania will be allowed to contend in bids against its ...Deccan Chronicle, 1 week ago
'I Want to Catch a Kuthu Before I Leave'
CHENNAI: She has worked with the likes of legends like Paul McCartney and the late Michael Jackson. Yoda Jones, who specialises in house, locking, waacking, popping, hip hop, freestyle and funk styles of dance, is in Chennai for the Funk-in India ...New Indian Express, 4 weeks ago
Pattiseema project in six months
Comment · print · T T T+· T- Chief Minister N. Chandrababu Naidu, on Wednesday said Pattiseema project would completed in six months. Mr. Naidu, who flew to Puattaparthy airport from Hyderabad in a special flight arrived, was received by ...The Hindu, 1 month ago
Airport to Go International in One Year: CM
VIJAYAWADA: The Gannavaram airport will be soon upgraded to international airport with a new permanent terminal building and all required facilities before Krishna Pushkarams, said Chief Minister N Chandrababu Naidu. Addressing newsmen at the ...New Indian Express, 1 month ago
Biased article
Kancha Ilaiah's article Chinese lessons for RSS (May 5) is biased. He totally ignores the good sides of Hinduism which are appreciated all over the world and is blind to the shortcomings of other religions. He also seems to be unaware of the Buddhist ...Asian Age, 1 month ago
Salman Khan
The verdict in the hit and run case once again shows that no one can escape the law (Editorial, May 7). Like many other cases involving political bigwigs and the high and mighty, this case too has been dragging on for far too long and it is good ...The Hindu, 1 month ago
Realtime News
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text:
Original recipe yields 4 servings
This is one of my favorite summer lunches! If I'm in a hurry I usually grate some cucumber into ranch dressing instead of making the sauce from scratch. I also enjoy spinach leaves instead of le...
Sorry, didn't really like this recipe. I didn't think it tasted much like a gyro. I do thank you for introducing me to Boca Burgers though, they ROCK!!! :o)


text:
Harbour Day Spa is perhaps the most beautiful day spa in Brisbane, overlooking the water of Raby Bay.
The beauty and body spa incorporates tropical Thai-influenced spa ingredients and treatments in a relaxed Queensland harbourside setting. The unique Thai facial incorporates natural ingredients and Thai massage techniques.
Massage restores balance and wellbeing enabling our bodies to move freely and rejuvenate. The skilled Massage therapists will customise your massage for relaxation.
The range of facials and beauty treatments offered at Harbour Day Spa for men and women (and specialized treatments for teens) are comprehensive - from Paramedical Skin procedures to Controlled Microdermabrasion to Anti Aging to Pigmentation control to acne and other skin problem solutions - to just having a facial for relaxation to give you a pick me up and a fabulous glow.
My husband and I visited the spa on our honeymoon after seeing all the awards and accolades they have received. Let me say, they deserve every one of them! We could not have had a more relaxing, romantic spa trip together. The staff is amazing. The views from the spa are beautiful. It was an incredible experience.
It was great that I could book online and the experience was perfect! The atmosphere as soon as you walk in is amazing.. pure tranquillity!
So many great comments - can't wait to come up and try!
Sounds devine. About time I gave myself a pampering with a spa day.
Sounds absolutely amazing. I have had short treatments before but never an actual spa package. I would love to try one one day when the kids are otherwise occupied. I need renewal!!


text:
Behind the Scenes of Roslyn
Microsoft's Channel 9 has released an interview with the principal developers of the Roslyn project. Karen Ng, Matt Warren, Peter Golde, Anders Hejlsberg provides some useful information on the project's goals and what the team is trying to accomplish.
The team has found that developers who want to build their own re-factoring tools have been limited in their ability to easily do so as it required them to build and maintain their own C# compiler. As Hejlsberg stated, "...I think a whole number of people want to build their own refactorings, or would want to build their own refactorings if it wasn't so hard..." The Roslyn project aims to lower the barrier to entry by opening up the compiler and the compilation process to C# and Visual Basic developers.
As the Roslyn project is written in managed code (C# or Visual Basic), the team was asked if this creates a performance hit. Hejlsberg and Ng responded that development in ASP.NET can see performance benefits from running Roslyn on the server since assemblies can be retained in memory. Golde indicated that in their experimentation, solutions that have several (10-30) smaller projects can see performance benefits when compiling as Roslyn keeps more data in memory. Warren followed that by saying that its too early for an overall performance comparison as the non-Roslyn C# compiler is quite fast but that testing and development work continues.
Hejlsberg noted that the current current C# compiler primarily uses 1 core, whereas the Roslyn compiler series is parallelized. The ability to introduce multi-core compatible code comes from the implementation of a more functional design in its internal architecture. Hejlsberg commented that "actually a lot of learnings from functional programming [were used] in how we implemented the compiler this time around". As another example, Roslyn takes advantage of C# method bodies that are completely independent of each other which allows them to be compiled in parallel.
Uses Beyond Refactoring
Ng noted that many developers have a need for parsers that support the C#/VB languages. Another need is for applications that want to be able to understand C# as an embedded scripting language. Hejlsberg thought another important area is meta programming; once the compiler becomes a service there are more opportunities for user interaction.
Meta-programming is defined by Hejlsberg as "programs generating programs". Upon being asked about template programming, Hejlsberg replied that he feels C++ template programming really involves two languages: C++ and then template-specific C++. By comparison, dynamic programming languages such as Ruby use the same object and meta languages. According to Hejlsberg Roslyn works the same way as C# can be used to extend C# without learning a new language or specialized dialect of a language.
C# / VB Compiler Revelations
The Roslyn project has also contributed to the amount of "dogfooding", or the practice of a company using its own products internally. Golde observes that "...even more interesting than writing the C# compiler in C# has been writing the VB compiler in VB... to be honest internally we haven't had a whole lot of VB development... this is the largest piece of 'shipping code' that we've written in VB". Warren added "...previously both compilers [C# and VB] were written in C, so all the compiler developers were C experts" but not necessarily experts in the language they were writing the compiler for. The self-hosted nature of the Roslyn compilers is then leading to situations where Microsoft developers can become more familiar with the "the beast that you are building" as Hejlsberg described it.
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text:
Shapes Match Pro
By OBAID INC Limited
Open iTunes to buy and download apps.
∞∞∞ Shapes Matching∞∞∞
--- 80% off 4 christmas---
* If you like Bejwelled then you definitely like this one.
Review by John Hatton from Australia.
• This game is very addictive and entertaining. I recommended to everyone around the world.
There are two modes in the game.
• Classic game which consist of 3D shapes.
• Simple game which consist of coloured buttons.
••• How to play the game •••
• Touch the 3D shapes or colours to remove it from the screen.
• A new Shape or colour takes that place.
• Match 3 or more shapes or colours to gain points and bonus of time.
• Unlimited play time as it increases after every match.
• Play fast and good use of mind then you will be master of this game.
Grab it play it and review it.
What's New in Version 2.0.1
• More shapes are added.
• Bugs fixed.
iPhone Screenshot
- Category: Games
- Updated: 29 February 2012
- Version: 2.0.1
- Size: 4.9 MB
- Language: English
- Developer: OBAID INC Limited
- © "Obaid inc 2011"
Compatibility: Requires iOS 3.1 or later. Compatible with iPhone, iPad, and iPod touch.