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Publications (16)26.27 Total impact
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Article: Efficacy and Safety of Abelmoschus manihot for Primary Glomerular Disease: A Prospective, Multicenter Randomized Controlled Clinical Trial[Show abstract] [Hide abstract]
ABSTRACT: Background Abelmoschus manihot, a single medicament of traditional Chinese medicine, has been widely used to treat kidney disease. This is the first randomized controlled clinical trial to assess its efficacy and safety in patients with primary glomerular disease. Study Design Prospective, open-label, multicenter, randomized, controlled, clinical trial. Setting & Participants From May 2010 to October 2011, a total of 417 patients with biopsy-proven primary glomerular disease from 26 hospitals participated in the study. Interventions A manihot in the form of a huangkui capsule, 2.5 g, 3 times per day; losartan potassium, 50 mg/d; or combined treatment, a huangkui capsule at 2.5 g 3 times per day, was combined with losartan potassium, 50 mg/d. The duration of intervention was 24 weeks. Outcomes & Measurements The primary outcome was change in 24-hour proteinuria from baseline after treatment. Change in estimated glomerular filtration rate (eGFR) from baseline after treatment was a secondary outcome. The 24-hour proteinuria was measured every 4 weeks and eGFR was measured at 0, 4, 12, and 24 weeks. Results Mean baseline urine protein excretion was 1,045, 1,084, and 1,073 mg/d in the A manihot, losartan, and combined groups, respectively, and mean eGFR was 108, 106, and 106 mL/min/1.73 m2, respectively. After 24 weeks of treatment, mean changes in proteinuria were protein excretion of −508, −376, and −545 mg/d, respectively (P = 0.003 for A manihot vs losartan and P < 0.001 for the combined treatment vs losartan). Mean eGFR did not change significantly. The incidence of adverse reactions was not different among the 3 groups (P > 0.05), and there were no severe adverse events in any group. Limitations Results cannot be generalized to those with nephrotic syndrome or reduced eGFR. Conclusions A manihot is a promising therapy for patients with primary kidney disease (chronic kidney disease stages 1-2) with moderate proteinuria.American Journal of Kidney Diseases 07/2014; 64(1). DOI:10.1053/j.ajkd.2014.01.431 · 5.76 Impact Factor
Article: Efficacy and safety of Changfu peritoneal dialysis solution: a multi-center prospective randomized controlled trial.[Show abstract] [Hide abstract]
ABSTRACT: A multi-center large scale study is needed to confirm the efficacy and safety of domestic peritoneal dialysis (PD) solutions. Some researchers believe that 6 L/d is enough for adequate dialysis, but there is no multi-center prospective study on Chinese population to confirm this. In this study, we evaluated the efficacy and safety of domestic PD solution (Changfu) and its difference between 6 L and 8 L dosage. Adult PD patients who had taken PD therapy for at least one month were selected and divided into four groups according to two dialysis solution brands and two dialysis dosages, i.e., 6 L dose with Changfu dialysis solution, 6 L dose with Baxter dialysis solution, 8 L dose with Changfu dialysis solution, and 8 L dose with Baxter dialysis solution. After 48 weeks, the changes of primary and secondary efficacy indices were compared between different types and different dosages. We also analyzed the changes of safety indices. Changes of Kt/V from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of creatinine clearance rate (Ccr). Normalized protein catabolic rate (nPCR) from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of net ultrafiltration volume (nUF) and estimated glomerular filtration rate (eGFR). Changes of nPCR from baseline to 48 weeks between 6 L and 8 L showed no statistical differences; so did those of nUF and eGFR. The decline of Kt/V from baseline to 48 weeks in 6 L group was more than that in 8 L group. Change of Ccr was similar. During the 48-week period, the mean Kt/V was above 1.7/w, and mean Ccr was above 50 L×1.73 m(-2)×w(-1). More adverse events were found in Changfu group before Changfu Corporation commenced technology optimization, and the statistical differences disappeared after that. The domestic PD solution (Changfu) was proven to be as effective as Baxter dialysis solution. During 48-week period, a dosage of 6 L/d was enough for these patients to reach adequate PD. Clinical study promotes technological optimization, further helps to improve the safety indices of the medical products.Chinese medical journal 11/2013; 126(22):4204-9. · 1.02 Impact Factor
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ABSTRACT: There is growing evidence for an association between chronic renal disease (CKD) and adverse cerebrovascular events because of the overlap of several risk factors. The purpose of this study is to examine the epidemiology of CKD and the characteristics of risk factors for CKD in the population with ischaemic stroke. This retrospective study included 571 patients with ischaemic stroke. Estimated glomerular filtration rate (eGFR) was calculated by the Modification of Diet in Renal Disease (MDRD) study equation. Renal function was assessed according to the Kidney Disease Outcomes Quality Initiative (K/DOQI)-CKD classification. Study demonstrated that the major factors associated with CKD in the ischaemic stroke patients were age, diabetes mellitus, hypertension, systolic blood pressure, LDL cholesterol and serum uric acid. Diabetes mellitus (OR 4·146, 95% CI 1·047-16·418, P = 0·043), hypertension and diabetes mellitus (OR 3·574, 95% CI 1·248-10·234, P = 0·018), serum uric acid (OR 1·010, 95% CI 1·006-1·013, P < 0·001) and LDL cholesterol (OR 1·431, 95% CI 1·063-1·928, P = 0·018) were independent risk factors associated with CKD in the patients with ischaemic stroke. The patients with ischaemic stroke may be considered as a high-risk population for CKD and be aggressively managed for CKD prevention. The high prevalence of CKD in population with ischaemic stroke prompts the need for greater public awareness about risks of CKD.European Journal of Clinical Investigation 08/2013; 43(8):829-35. DOI:10.1111/eci.12113 · 2.83 Impact Factor
Article: Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients.[Show abstract] [Hide abstract]
ABSTRACT: Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease (CKD) patients are limited. The aim of the present study was to investigate the prevalence, awareness, treatment, and control of hypertension in the non-dialysis CKD patients through a nationwide, multicenter study in China. The survey was performed in 61 tertiary hospitals in 31 provinces, municipalities, and autonomous regions in China (except Hong Kong, Macao, and Taiwan). Trained physicians collected demographic and clinical data and measured blood pressure (BP) using a standardized protocol. Hypertension was defined as systolic BP ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg, and/or use of antihypertensive medications. BP < 140/90 mmHg and < 130/80 mmHg were used as the 2 thresholds of hypertension control. In multivariate logistic regression with adjustment for sex and age, we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD patients. The analysis included 8927 non-dialysis CKD patients. The prevalence, awareness, and treatment of hypertension in non-dialysis CKD patients were 67.3%, 85.8%, and 81.0%, respectively. Of hypertensive CKD patients, 33.1% and 14.1% had controlled BP to < 140/90 mmHg and < 130/80 mmHg, respectively. With successive CKD stages, the prevalence of hypertension in non-dialysis CKD patients increased, but the control of hypertension decreased (P < 0.001). When the threshold of BP < 130/80 mmHg was considered, the risk of uncontrolled hypertension in CKD 2, 3a, 3b, 4, and 5 stages increased 1.3, 1.4, 1.4, 2.5, and 4.0 times compared with CKD 1 stage, respectively (P < 0.05). Using the threshold of < 140/90 mmHg, the risk of uncontrolled hypertension increased in advanced stages (P < 0.05). The prevalence of hypertension Chinese non-dialysis CKD patients was high, and the hypertension control was suboptimal. With successive CKD stages, the risk of uncontrolled hypertension increased.Chinese medical journal 06/2013; 126(12):2276-2280. · 1.02 Impact Factor
Article: Serum levels and activity of indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase and their association with disease severity in patients with chronic kidney disease.[Show abstract] [Hide abstract]
ABSTRACT: Abstract Objective: This study aims to test the serum levels and activity of indoleamine2,3-dioxygenase(IDO) and tryptophanyl-tRNA synthetase (TTS) in patients with chronic kidney disease (CKD) and to evaluate their association with disease severity. Method: Serum concentrations of IDO and TTS in 61 patients with CKD and 16 healthy volunteers were tested by ELISA. Tryptophan and kynurenine concentrations were measured by high-performance liquid chromatography (HPLC). Results: Patients with CKD showed higher serum levels of IDO and TTS in comparison to healthy controls (p = 0.001). Patients with CKD showed lower serum levels of tryptophan and higher serum levels of kynurenine in comparison to healthy controls (p < 0.001). The kyn/Trp ratio significantly correlated with the disease severity in CKD patients (r = 0.721; p < 0.001). Conclusions: IDO and TTS may play critical roles in the immune pathogenesis of CKD. The activity of IDO correlated with the disease severity of CKD.Biomarkers 05/2013; 18(5). DOI:10.3109/1354750X.2013.790074 · 2.52 Impact Factor
Article: [Atorvastatin attenuates parathyroid hormone1-34 induced cardiomyocytes hypertrophy through downregulating K-Ras-ERK1/2 pathway].[Show abstract] [Hide abstract]
ABSTRACT: To investigate the effects of atorvastatin on parathyroid hormone1-34 (PTH1-34) induced neonatal rat cardiomyocytes hypertrophy and on the expression changes of small GTP-binding protein (K-Ras) and extracellular signal regulated protein kinases 1/2 (ERK1/2). Neonatal rat cardiomyocytes hypertrophy was established with 10(-7) mol/L rPTH1-34 in the presence or absence of 10(-5) mol/L atorvastatin or 10(-4) mol/L mevalonic acid (MVA). Cardiomyocyte diameter was measured by Motic Images Advanced 3.0 software, the synthetic rate of protein in cardiomyocytes was determined by (3)H-leucine incorporation and single-cell protein content was measured by BCA. The concentration of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were determined by ELISA. Protein expression of ERK1/2, p-ERK1/2 and K-Ras was detected by Western blot. Compared to PTH1-34 group, cellular diameter was decreased 12.07 µm, (3)H-leucine incorporation decreased 1622 cpm/well and single-cell protein content decreased 84.34 pg, ANP or BNP concentration reduced 7.13 µg/L or 20.04 µg/L, protein expression of K-Ras, ERK1/2 or p-ERK1/2 downregulated 0.81, 0.19 and 1.44 fold, respectively, in PTH1-34 plus atrovastatin co-treated cardiomyocytes (all P < 0.05). Compared to PTH1-34 plus atrovastatin co-treated group, cardiomyocyte diameter increased 4.95 µm, (3)H-leucine incorporation increased 750 cpm/well and single-cell protein content increased 49.08 pg, ANP or BNP increased 3.12 µg/L or 9.35 µg/L and protein expression of K-Ras, ERK1/2 or p-ERK1/2 upregulated 0.52, 0.06 and 1.19 fold (all P < 0.05) in MVA, PTH1-34 and atrovastatin co-treated cardiomyocytes. Atrovastatin attenuates PTH1-34 induced neonatal rat cardiomyocytes hypertrophy through downregulating K-Ras and ERK1/2 pathway.Zhonghua xin xue guan bing za zhi [Chinese journal of cardiovascular diseases] 12/2012; 40(12):1051-5.
Article: Treatment of 5/6 nephrectomy rats with sulodexide: a novel therapy for chronic renal failure[Show abstract] [Hide abstract]
ABSTRACT: Sulodexide, a glycosaminoglycan, could reduce albuminuria in diabetic patients. The aim of this study was to determine whether sulodexide could be used to treat chronic kidney failure in rats. Sixty Wistar rats undergone 5/6 nephrectomy, then were randomly divided into 4 groups: the model group, sulodexide group (sulodexide 5 mg/kg per day, im), irbesartan group irbesartan (20 mg/kg per day, ig) and sulodexide plus irbesartan group. Another 12 rats were enrolled into the sham operation group. After the treatments for 4, 8 and 12 weeks, urinary protein and serum creatinine levels were measured. After 12 weeks, serum cholesterin and triglycerides levels were measured, and the degrees of glomerular sclerosis and renal tubulointerstitial fibrosis were scored. The expression of aminopeptidase P (JG-12) in the renal tissue was examined using immunohistochemical staining. The renal expressions of endothelial nitric oxide synthase (eNOS) and tissue type plasminogen activator (tPA) were detected with RT-PCR and Western blot. Proteinuria was markedly attenuated in the sulodexide-treated groups. After 4 and 8 weeks only the sulodexide-treated groups showed significant reduction in serum creatinine; while after 12 weeks all the three treatment groups showed significant reduction in serum creatinine. Furthermore, all the three treatment groups showed significant reduction in the scores of glomerular sclerosis and tubulointerstitial fibrosis. The glomerular expression of JG-12 was increased in both the sulodexide group and the sulodexide plus irbesartan group, but not in the irbesartan group. The eNOS mRNA and protein expression was decreased and the tPA mRNA and protein expression was significantly increased in the model group compared with Sham group. Sulodexide, irbesartan, and their combination reversed the decrease of eNOS expression but increased the tPA expression much more compared with model group. Sulodexide was similar to irbesartan that can decrease proteinuria and attenuate renal lesions in 5/6 nephrectomy rats. The renal protection by sulodexide might be achieved via its impact on renal vascular endothelial cells.Acta Pharmacologica Sinica 05/2012; 33(5):644-51. DOI:10.1038/aps.2012.2 · 2.50 Impact Factor
Article: Prevalence and risk factors for chronic kidney disease in patients with coronary artery disease[Show abstract] [Hide abstract]
ABSTRACT: Chronic renal disease (CKD) is recognized as a worldwide public health problem. Traditional risk factors for CKD are also present in coronary artery disease (CAD). The purpose of this study is to examine the prevalence and characteristics of risk factors for CKD in the population with CAD. Renal function was evaluated in 527 patients with CAD in order to assess characteristics of the incidence, risk factors for CKD in the population with CAD. In the present study in order to concentrate on evaluation for eGFR of the patients with CAD proteinuria is not included in the definition of CKD. Univariate analysis demonstrated that the major risk factors associated with CKD in the patients with CAD were age (P ≤ 0.001), smoking (P = 0.016), diabetes mellitus (P = 0.021), hypertension (P ≤ 0.001), and systolic blood pressure (P = 0.004). The percentages of patients with both hypertension and diabetes mellitus were significantly greater in the CKD3-4 group (P < 0.001). The results of multivariable analysis showed that hypertension (OR 1.925, 95% CI 1.196-3.098, P = 0.007), diabetes mellitus (OR 1.744, 95% CI 1.044-2.914, P = 0.034) and serum uric acid (OR 1.008, 95% CI 1.006-1.010, P ≤ 0.001) were independent risk factors for reduced eGFR. CKD is common and has a high prevalence in the population with CAD. Several risk factors are known to simultaneously affect heart and kidney. The patients with CAD may be considered as a high-risk population for CKD.Current Medical Research and Opinion 02/2012; 28(3):379-84. DOI:10.1185/03007995.2012.661708 · 2.37 Impact Factor
Article: Characterization of interleukin-33 and soluble ST2 in serum and their association with disease severity in patients with chronic kidney disease.[Show abstract] [Hide abstract]
ABSTRACT: This study aims to test the serum levels of interleukin-33 (IL-33) and soluble ST2 (sST2) in patients with chronic kidney disease (CKD) and to evaluate their association with disease severity. Sixty-nine patients with CKD were enrolled, disease severity was assessed, and clinical data were collected. Twelve healthy volunteers served as healthy individuals. Serum IL-33 and sST2 were tested by enzyme-linked immunosorbent assay. The patients were classified into five categories based on their estimated glomerular filtration rate (eGFR). No difference was found as to the serum concentration of IL-33 between CKD patients and healthy individuals (p = 0.656), while a higher serum level of sST2 was found in CKD patients (p = 0.003). The correlation analysis revealed a significant correlation between the serum level of sST2 and disease severity (r = 0.586; p < 0.001). A higher level of sST2 was found in CKD patients with elevated parathyroid hormone (p = 0.001). Serum sST2 correlated with parathyroid hormone (r = 0.412; p < 0.001), serum phosphorus (r = 0.545; p < 0.001), and serum calcium (r = -0.494; p < 0.001). An elevated concentration of serum sST2 is found in CKD patients and correlates with disease severity. Serum sST2 may be also associated with parathyroid hormone disorder of CKD. The sST2 may have an important role in the development of CKD or as a marker of disease severity.Journal of Clinical Immunology 12/2011; 32(3):587-94. DOI:10.1007/s10875-011-9622-7 · 2.65 Impact Factor
Article: An evaluation of the RIFLE criteria for acute kidney injury after myeloablative allogeneic haematopoietic stem cell transplantation[Show abstract] [Hide abstract]
ABSTRACT: Patients undergoing myeloablative allogeneic haematopoietic stem cell transplantation (HSCT) have a higher incidence of acute kidney injury (AKI). RIFLE is a newly developed classification for AKI that includes three grades of severity - AKI-R, AKI-I, AKI-F. The purpose of this study was to analyse retrospectively major risk factors for AKI at the time of myeloablative allo-HSCT and to use the RIFLE criteria to predict mortality in myeloablative allo-HSCT. Renal function was evaluated in 143 patients with allo-HSCT by RIFLE criteria in order to assess the incidence, risk factors and mortality rate of various degrees of AKI. The results of this study showed that patients with hepatic veno-occlusive disease (HVOD) have a higher incidence of AKI-F than those without HVOD (P = 0.002). The incidence of AKI-I and AKI-F in patients with grade III-IV acute graft-versus-host disease (aGVHD) and increased total bilirubin was significantly higher than in those without (P = 0.001, P <0.001). HVOD was an independent risk factor of AKI-F (OR 5.058, 95% CI 1.317-19.424, P = 0.018), and increased total bilirubin was an independent risk factor for AKI-F (OR 5.126, 95% CI 1.403-18.998, P = 0.014). Worsening RIFLE category was associated with increased mortality of the patients in the 100 days post-transplant (P = 0.003). In addition, 180-day survival of patients in different AKI classes was significantly different (P = 0.0095). AKI is common in patients with myeloablative allo-HSCT and is associated with increased risk of death. The RIFLE criteria appear to be an important tool for stratification of these patients on the basis of death risk.Schweizerische medizinische Wochenschrift 07/2011; 141:w13225. DOI:10.4414/smw.2011.13225 · 1.88 Impact Factor
Article: The regulation of CD4+ T cell immune responses toward Th2 cell development by prostaglandin E2[Show abstract] [Hide abstract]
ABSTRACT: As an important immune mediator, PGE2 plays an important role in the immune tolerance, autoimmune diseases, immune regulation and tumor immunotolerance. PGE2 is considered to be a promising candidate for the control of the immune diseases. To further understand the immuno-modulating effects of PGE2 on CD4+ T cells, in vitro investigation was conducted in the present study. The results showed that PGE2 inhibited the proliferation of T cells in vitro in a dose-dependent manner. Gene expression profiling showed that 1716 genes were down regulated and 73 genes were up regulated with a change of 1.5 fold. Several signal transduction pathways were involved, such as TNF-α and NF-kB signaling pathway, T cell receptor signaling pathway, IL-2 signaling pathway, and MAPK pathway. The results showed that PGE2 inhibited IFN-γ, TNF-α and IL-4 production by CD4+ T cells 24h after cell culture. A comparison between IFN-γ and IL-4 production showed that PGE2 enhanced the relative ratio of IL-4 to IFN-γ in CD4+ T cells culture, and regulated CD4+ T cells toward Th2 cell development. The results of the present study indicated that PGE2 has the potential to treat Th1-mediated inflammatory diseases by regulating CD4+ T cells toward Th2 cell immune response.International immunopharmacology 05/2011; 11(10):1599-605. DOI:10.1016/j.intimp.2011.05.021 · 2.71 Impact Factor
Article: [Effect of telmisartan on tubulointerstitial injury and expression of PPARγ in rat renal tissue of IgA nephropathy model].[Show abstract] [Hide abstract]
ABSTRACT: To observe the effect of telmisartan on the expression of PPARγ in rat renal tissue of IgA nephropathy model and clarify the possible mechanism of telmisartan in tubulointerstitial injury. The experimental rat model with IgA nephropathy was induced by bovine serum albumin (BSA), lipopolysaccharide (LPS) and carbon tetrachloride (CCl4). Forty male SD rats were randomly divided into control group, IgA model group, rosiglitazone group, telmisartan group and losartan group. At pre-administration, Weeks 4, 8 and 10, the quantity of 24-hour proteinuria was measured. The morphologic changes of renal tissues were evaluated by electron microscope. Immunohistochemistry was used to observe the expressions of PPARγ, TGF-β1 and α-smooth muscle actin (α-SMA) in different groups and RT-PCR to detect the expressions of PPARγ, TGF-β1 and monocyte chemoattractant protein-1 (MCP-1) in different groups. Compared with control group, 24-hour proteinuria(mg) increased markedly in IgA model group (14.14 ± 1.99 vs 1.59 ± 0.18), but rosiglitazone group (2.35 ± 0.33), telmisartan group (1.88 ± 0.09) and losartan group (2.82 ± 0.34) was much lower and telmisartan had the most significant effect (all P < 0.05). Compared with control group, there were varying degrees of mesangial proliferation and infiltration of inflammatory cell in IgA model group (3.10 ± 0.18). The tubulointerstitial injury was notably alleviated in rosiglitazone group (1.97 ± 0.23), telmisartan group (1.57 ± 0.14) and losartan group (2.15 ± 0.22) while telmisartan had the most significant effect (all P < 0.01). With immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR), PPARγ, TGF-β1, α-SMA and MCP-1 had minimal expression on tubule and interstitium in normal group. But there was a high expression in model group. There was no difference between losartan and model groups. There was a lowered expression in rosiglitazone and telmisartan groups. Possibly through two separate passway of stimulating PPARγ and preventing Angiotensin II receptor, telmisartan shows special protective function in tubulointerstitial injury.Zhonghua yi xue za zhi 11/2010; 90(40):2860-3.
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ABSTRACT: To measure the expression of CD80 and CD86 in renal tissue of lupus nephritis (LN) and explore its mechanism in the development of LN. Forty-nine patients with active LN and 9 patients with minor glomerular abnormalities tissues as controls were studied. The expression of CD80 and CD86 in renal tissues was detected by immunohistochemical methods. CD86 was expressed extensively in glomerulus, periglomerular area, tubular epithelial cells and peritubular interstitium, while CD80 was expressed only in tubular epithelial cells and peritubular interstitium. Moreover, the percentage of CD80+ and CD86+ cells in tubular epithelial cells and peritubular interstitium showed a tendency to increase with tubulointerstitial damage. The expression of CD80 and CD86 in renal tissue correlated with the systemic lupus erythematosus (SLE) disease activity index score, the degree of proteinuria, creatinine clearance and anti-dsDNA antibody. This study shows that increased CD80 and CD86 expression with the progression of tubulointerstitial lesion might play an important role in the development of lupus nephropathy, and the tubulointerstitial expression of CD80 and CD86 could potentially serve as a surrogate marker of SLE disease activity. The co-stimulatory molecules CD80 and CD86 might play an important role in the pathogenesis of LN.Zhonghua nei ke za zhi [Chinese journal of internal medicine] 08/2010; 49(8):691-5.
Article: Interleukin-10 genotype protects end stage renal disease patients from microinflammation and arteriosclerosis.Chinese medical journal 10/2005; 118(18):1549-51. · 1.02 Impact Factor
Article: [The research on the relationship between the polymorphism of 1082A/G, anti-inflammatory interleukin-10 gene promoter with its effect of preventing ESRD patients from microinflammation and arteriosclerosis].[Show abstract] [Hide abstract]
ABSTRACT: We do this investigation in order to reveal the relationship between the polymorphism of 1082A/G, anti-inflammatory interleukin-10 gene promoter, and end stage renal disease (ESRD) patients microinflammatory state and arteriosclerosis (AS). We used PCR-RFLP to measure the various kinds of distribution of IL-10 gene-1082A/G genotype and relevant indexes of microinflammatory state and AS of 870 ESRD patients and 1000 healthy persons of control group and to analyze the mechanism of its protection effect keeping ESRD patients away from microinflammation and arteriosclerosis. Compared with the control group, CRP, TNF-alpha, CH50, C3, IL-10 and Alb of ESRD group were in the normal range, but still significantly higher than those of the control group, while IL-10, Alb were significant lower (P < 0.05). The genotype distribution and allele frequency of IL-10A/G gene had no significant differences between the healthy group and the control group (P > 0.05). Levels of CRP, TNF-alpha, CH50 and C3 of ESRD patients with IL-10A/A genotype were significantly higher than those of ESRD patients with G/G and G/A genotype (P < 0.05), while IL-10 and Alb were significantly lower (P < 0.01). The production of IL-10 in serum from patients with IL-10A/A genotype was significantly lower than that of patients with G/G and G/A genotype (P < 0.01). The incidence rate of AS of patients with IL-10-1082A/A genotype was significantly higher than that of patients with G/G and G/A genotype (P < 0.01). The raise of AS incidence rate was correspondent with the decline of serum IL-10 and raise of serum CRP and Fib. The IL-10A/A genotype is a predictable factor of microinflammatory state and high AS incidence rate in ESRD patients. We use IL-10G/G genotype to modulate the high production of serum IL-10, to decline inflammatory reaction and to keep away from microinflammation and AS in ESRD patients. We should work hard on improving the dialysis membrane to reduce the anti-inflammatory factors in uremia for chronic renal failure patients with high arteriosclerosis risk.Zhonghua yi xue za zhi 08/2005; 85(29):2076-80.
Article: [Relation between Leptin receptor gene polymorphisms, renal substantial hypertension and kidney damage in hypertension].Zhonghua yi xue za zhi 07/2004; 84(11):915-7.
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Harbin Medical UniversityCharbin, Heilongjiang Sheng, China


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Actress Ali Landry and her family attend the 'Santa Paws 2: The Santa Pups' holiday party hosted by Disney, Landry and Cheryl Ladd in Santa Monica, Calif. on November 10, 2012.
Yep, the whole world just saw Tyga's penis.
Chrissy Teigen just added to the thirst that is currently erupting on Instagram.
Celebs have really hot siblings, and we think you should know about them!

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Sep 13
The Heaves at Hank's Saloon
Nov 17
We are psyched to be part of Astoria's first BBQ BEER GARDEN, The Strand's, Grand Opening! Come get yourself some amazing BBQ, great music all day and night, and to top it off a huge array of beers, whiskeys, and moonshine! Jazz in the morning for brunch, leading into some acoustic folk/country, and then wrapping up the night with some Country Rock get down tunes with Dead Amble! Easy to get to right off the Broadway stop on the N or Q trains in Astoria on Broadway btwn 29th St. & Crescent. You can't miss the awesome hand made wood tables out front and the huge glass windows displaying all the barrels of goodness! FREE FREE FREE The Strand 25-31 Broadway, Astoria (Broadway btwn 29th St. & Crescent) All day Bluegrass/Folk/Country Jams Lineup (in progress): 7:00 PM - Sean Kershaw & The Terrible Two 8:00 PM - Hickry Hawkins 9:30 PM - DEAD AMBLE
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Come on out for a FREE work night country-beach-tiki hoedown with Hickry Hawkins and your lovable Dead Amble boys!!! Otto's Shrunken Head - Tiki Bar & Lounge NYC 10:00PM - Hickry Hawkins 11:00PM - Dead Amble 21+ FREE SHOW!!!!
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Bio: "Imagine a long white Cadillac with Hank Williams, Sr. driving, Steve Earle riding shotgun, David Lee Roth in the backseat and the body of Sid Vicious banging around in the trunk!"
Somebody will have to shoot Hick'ry Hawkins before he'll ever stop playin'! With a sound most often compared to ...See Full Bio
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""the David Lee Roth of Country music""


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Willie Lee Kirkland came out the winner of last week's Chronicle-Independent weekly football contest.
Photo cutline -- Marching proudly -- Members of the Lugoff-Elgin Marching Pride got the first halftime performance under their belt last Friday. Vicki Jordan perked up before taking the field to play the xylophone and Donald Quails and David Earnhart put all their energy into the mellophone.
Don't be surprised if some member of the S.C. General Assembly reads of the new 85-mile-an-hour speed limit in Texas and decides that would be a good idea for the Palmetto State. We hope that won't happen, but we'll never be flabbergasted at any proposal that includes a higher driving speed, which to some lawmakers equates with motherhood and apple pie.
When people ask me if I would not like to be young again --- specifically to be a teenager, I am sure they have forgotten the age. Also, when they ask me how I tolerated teaching that age, I know they are mistaken. One person even told me what a waste of time my occupation had been! Being a teenager is one of the most difficult yet rewarding times of a person's life. The effort to become independent is so hard. When my mother became annoyed when anyone called me "pretty" and coupled it with the compliment about her grandchild ...
The 52-year-old Elgin man suspected of the kidnapping of a 16-year-old Northeast Columbia teen and a suspect in the disappearance of a 28-year-old Florida native has had a history of slipping through the legal system.
Funeral service for Frances Delores Disher Osteen, 67, will be held Thursday at 1:00 p.m. at Powers Funeral Home, Lugoff, with burial to follow in Mt. Olivet Baptist Church Cemetery. The Rev. Richard Cameron and the Rev. Derrick Proctor will officiate. The family will receive friends Wednesday 6-8 p.m. at Powers Funeral Home. Memorials may be made to New Life Christian Outreach Church Building Fund, 313 Thrush Lane, Lugoff, S.C. 29078.
Mr. Tommie L. Ransom, 70, of 1060 Marshall Road, Camden, SC, passed on Saturday, September 8, 2012. Funeral services will be conducted on Thursday, September 13, 2012, 3 p.m., at Pine Grove AME Church, Rembert, SC, with burial to follow in Sandhill Cemetery, Rembert.
(The online version of this story has been corrected to reflect, as indicated in the second paragraph, that "...the explosion resulted in the release of chemicals..." and not "from the release" as published in Wednesday's print edition of the story. The C-I apologizes for any confusion.)
The following real estate transfers were recently recorded in the Kershaw County Assessor's office:
Being in a working family in this age is very difficult without the help of others. As a father of three, there is hardly ever enough time or resources close to me to create the healthy environment I would like for my family. As a former Camden high athlete, I know how important staying in touch with your health and your community really is, and that is why I am proud to support the effort for a Camden YMCA!
CHARLOTTE, N.C. -- There's no point trying to find something wrong with Michelle Obama's speech to the Democratic National Convention. It was perfection.
The seventh annual Carolina Challenge Volleyball Tournament will be held on Saturday, Sept. 22 inside The Castle at North Central High School.
For the third year in a row, Camden Walmart has partnered with the Kershaw County School District (KCSD) to sponsor the Stuff a Bus promotion, making the students the real winners.
• Penn State pedophile Jerry Sandusky says he regrets not testifying at his child sex-abuse trial earlier this year. Sandusky, who's awaiting sentencing after being convicted of multiple counts of abusing young boys, still maintains his innocence despite crushing evidence against him and the testimony of several of his victims. Sandusky isn't likely to convince anyone that he's innocent.
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Mrs. Clara Nelson Wood, 90, of 530 Longtown Rd, Lugoff, SC passed away peacefully at her residence on Monday, June 22, 2015. She was a graduate of Benedict College and she retired as a teacher from the Kershaw County Public School System. Funeral services for Mrs. Wood will be held at 11 a.m. today, June 26, 2015 at Sutton Branch Baptist Church, 420 Sutton Branch Road, Lugoff, with interment in the church cemetery. Public viewing was Thursday, June 25, 2015 from 2-7 p.m.
Mr. Terry Anthony Pough, 39, of 1463 Wells Road, Camden, South Carolina passed on Tuesday, June 23, 2015. Funeral arrangements are incomplete and will be anounced at a later date by Nelson-Haile Funeral Home.
Mr. Milton Jones, 78, of 225 Crescent Circle, Camden, South Carolina passed on Saturday, June 20, 2015. Funeral services will be conducted at noon Saturday, June 27 in New Hope Baptist Church, Bishopville. The family will be receiving friends at the home.
Memorial services for Milton Loman Griswold, age 50, of the Batesville Community, Clarkesville, Georgia will be held Saturday, June 27, 2015 at 3 p.m.from Hillside Memorial Chapel with Rev. Anthony Rabern officiating. The family will receive friends prior to the memorial service from 1-3 p.m.
Funeral services for Douglas Matthew "Doug" Gordon, 42, will be held Saturday at 4 p.m. at Malvern Hill Baptist Church, with burial to follow in the church cemetery. The Rev. Buster Morris will officiate. The family will receive friends Friday from 6-8 p.m. at Powers Funeral Home. In lieu of flowers, memorials may be to the American Heart Association.
In preparing for this coming fall season, the Camden High School girls' golf team is seeking players who would like to join the team.
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PRLog - May 21, 2010 - DALLAS -- Attention family, friends and fans..you are going to want to save this date for Dallas Derby Devils Gallery Night. Gallery Night is a once a year event to showcase DDD photographers and supporters.
Gallery Night
This is a artsy classy upscale event that includes photographers, artists in many mediums, vendors, bands, silent auction and refreshments.
Gallery Night will be Sat June 12 at the Continental Lofts
located at 3311 Elm Street, Dallas, TX 75226
We will set up Friday June 11 for 5-9 ihs and will be available for Artist set up Sat if needed. The event will officially start at 7:30 PM on Sat.
If you are are photographer, vendor, band or artist and would like to be involved with this event please contact Siouxsie at email@example.com by June 1st so we can save you a spot.


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Digital Media Doctor (PC) 18.104.22.168
Digital Media Doctor works with Digital Cameras and Camcorders, Palm Pilots, MP3 players and more. This utility performs diagnostic tests, using innovative algorithms, to determine device integrity. Benchmark tests, with various read and write modes, are included. Reports on how well the media is functioning are created upon analysis completion. Customize the number of blocks per read, test time length and even fix logical read errors.
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Sib Icon Converter converts multiple digital images and photos into Windows 7 icons. You can add files and folders from Windows Explorer or other file shells using drag and drop, and you can break down entire icon libraries into individual icons. You can change color resolution and size to create customized icons. Sib Icon Converter allows you to extract icons from folders and libraries. It's easy to process multiple files at once.
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CustomIcons 5.12
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DVD-Cloner Platinum 2015
DVD-Cloner Platinum is powerful DVD copy/conversion/burn software. It has all the features of DVD-Cloner plus the ability to convert all your DVD movies to iPod Nano, Classic and Touch. It's a user-friendly program with excellent output quality. The latest version utilizes OCT™ to ensure the highest level of success copying latest DVD movies. Give it a try and you'll find your ideal multimedia solution! Key features: Perfect 1:1 DVD Copy Customized DVD copy Directly transports DVD files from PC to iPod without iTunes! Supports the conversion of latest DVD movies. DVD-Cloner Platinum contains two products: DVD-Cloner and iPod-Cloner DVD-Cloner is a powerful DVD copy/burn/decryption tool with its diverse customized copy modes, no matter full disc copy or main movie copy. With only one click, you'll experience the most convenient DVD copy software with 13 years' progressive development. Key features: Remove ...
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The Free Excel Contact Scheduler can easily schedule all of you contacts, and send out customized reminder emails automatically. Scheduling multiple, recurring appointments easily, and sort contacts alphabetically at the click of a button. Contact Names are filled in automatically after just a few keystrokes. This Week and This Month view schedules allow for easy viewing and navigating. Important contact data can be auto-added in a pop-up comment
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Aiseesoft Blu-ray Creator 1.0.82
Aiseesoft Blu-ray Creator can be used to creating Blu-ray disc, Blu-ray folder and ISO files from MP4, VOB, WMV, MXF, AVI, VOB, FLV, M2TS, TP video formats. And it also allows users to customize the Blu-ray effect, including crop video segment, edit the source video, add watermark or add audio tracks and subtitles to the target Blu-ray. Besides, there are lots of menu template provided for you to choose.
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Swift To-Do List 8.064
Number one to-do list software for Windows suitable for personal and business use. All your tasks and notes in one place. Powerful yet simple and easy to use. Features include: To-do list tree with icons, recurrent tasks, reminders, task archive, runs from USB thumbdrive, attachments, great export & printing, email tasks, undo/redo, clipboard support, database encryption, reorder tasks using mouse, view modes and filters, customize everything.
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Free and innovative to-do list software with reminder and task lists organized by tree structure with icons, suitable both for personal and business use. All to-do tasks can have customized priority level, type, due date, and reminder. Advanced exporting and printing capabilities! You will never forget anything thanks to the inbuilt reminder, which can be activated for any of your tasks. Never forget anything again!
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AVCWare Video Converter Ultimate 184.108.40.2063
An all-in-one video converter software - AVCWare Video Converter Ultimate is capable of converting nearly all popular video formats like AVI, MP4, MKV, FLV, MPEG, WMV, DivX, RM, MOV, 3GP and audio formats MP3, WMA, WAV, RA, M4A, AAC, AC3, OGG between each other. With it, you can even clip, cut, split, join, edit videos easily. Functions 1. Convert HD and SD video formats 2. Convert between Various Audio formats 3.Create Videos from Pictures 4.Clip Video Segments 5.Combine Files into One 6.Split One files into Several Parts Features 1.Support all kinds of video formats including: AVI, MPEG, WMV, MP4, FLV, MKV, H.264/MPEG-4, DivX, XviD, MOV, RM, RMVB, M4V, VOB, ASF, 3GP, 3G2, SWF, AVCHD, TS. 2. Support almost all audio formats including MP3, WMA, AAC, WAV, CDA, OGG, FLAC, APE, CUE, M4A, RA, RAM, AC3, MP2, AIFF, AU, MPA, SUN AU. 3.Create customized videos from your picture collections and view them on multimedia players with your friends. 4.Clip video segments and merge them into one. 5.Y ...
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Free WiFi Hotspot Share 12.2.1
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Xilisoft Blu-ray Creator 220.127.116.113
Xilisoft Blu-ray Creator 2 helps you create Blu-ray discs from various videos for playback on any Blu-ray players. With the Blu-ray creator, you can easily burn your videos to Blu-ray discs (BD-R, BD-RE, BD-25, BD-50), and AVCHD on DVDs (DVD-5, DVD-9, DVD-R, DVD+R, DVD-RW, DVD+RW, DVD+R DL, DVD-R DL). Besides, it supports converting videos to BDMV ISO and AVCHD ISO. Additionally, the powerful editing tools enable you to customize your Blu-ray movie by trimming video, cropping video playing region, adding subtitle/audio/watermark and adjusting image settings. Creating Blu-ray DVD menu from numerous templates and adding several titles into one disc are all available. 1.Rich Blu-ray DVD menu templates in different styles are offered for easy DVD menu creation. 2.Introduce NVIDIA CUDA accelerating technology to pursue the highest DVD creating speed. 3.Provide power management options in this Blu-ray to DVD Creator. 4.Nearly all types of DVD discs, Blu-ray discs, and common videos are supported. 5.Conve ...
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DreamPlan Home Design Software 1.00
Free home and landscape planning and design software for Windows. Build your dream home and the landscape you've always wanted in minutes all in 3D. Design a home or apartment with endless layout options. Customize paint and textures. Design kitchens and bathrooms. Add furniture, appliances, fixtures and other decorating options. Build up or lower the terrain of your yard for added character or curb appeal. Add a patio, garden, trees, and more.
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Celebrities and Entertainment News
Celebrity news, rumors and gossip
Monthly Archive for July, 2012
Russell Brand charged with criminal damage after iPhone smash
British comedian Russell Brand is due to be arraigned in court later this week on a charge of criminal damage to property following a clash with a photographer in March. The star stands accused of snatching a photographer's iPhone and hurling it through the window of an abandoned building in New Orleans, La. He turned […] [Read More]
Jennifer Lopez's red-hot birthday
Jennifer Lopez's boyfriend Casper Smart treats her to a surprise bash. See pics of the stunning star enjoying her lavish celebration. [Read More]
Dave Grohl credits with the Beatles with inspiring his rock career
Dave Grohl has branded the Beatles "the most important rock band of all time" and credits the Fab Four with inspiring his music career. The Foo Fighters star has written an open letter praising the band to coincide with the release of a new compilation of its tracks, which was available on iTunes from Tuesday. […] [Read More]
Kristen Stewart apologizes for affair with 'Snow White' director
Kristen Stewart has apologized to fans and boyfriend Robert Pattinson after photos that appeared to show the actress kissing her married "Snow White and the Huntsman" director Rupert Sanders were made public on Wednesday. Stewart met Pattinson on the set of the vampire film franchise in 2008 and their onscreen romance quickly spilled over into […] [Read More]
TJ Jackson awarded temporary guardianship of Michael's kids
Michael Jackson's mother Katherine has been suspended as the guardian of the King of Pop's three children following the controversy surrounding her recent trip to Arizona. Katherine Jackson sparked concerns about her whereabouts and wellbeing last week following conflicting reports about her location. The 82 year old's nephew, Trent Jackson, allegedly filed a missing persons […] [Read More]
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Interactive Seating Charts
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a seating chart for Orange County Great Park.
Orange County Great Park6950 Marine Way
Irvine, CA 92618
Upcoming Events
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About Seatgeek
We scour the web's major ticket sites and aggregate inventory into one place. Our Deal Score helps you identify the best ticket deals available for each event.Learn more about SeatGeek


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Shopping Tools
Get email updates on new products and offers.
Share information. Ask questions. Connect with our Customer Service team and other business vehicle customers.
New innovative way to manage Fleet vehicles
GM has partnered with Telogis, Inc. to provide a cloud-based location intelligence platform that helps fleet managers operate their fleets more efficiently and identify cost savings.
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The bi-fuel CNG option pricing will start at $9,5001 for the Chevy Silverado and GMC Sierra 2500HD and 3500HD single rear-wheel pickups when they go on sale in July. A dedicated CNG option on the Chevy Express and GMC Savana cargo and passenger short-wheelbase vans starts at $10,8251 for the three-tank system and $12,0901 for the four-tank system.
Learn more about Bi-Fuel CNG pricing
Joining the Police Lineup: Silverado Special Service Vehicle
Introducing the 2015 Chevy Silverado 1500 Crew Cab Special Service Vehicle (SSV). Powered by a potent 5.3L V-8 engine, it offers durability and features designed specifically for police use, including a 170-amp alternator and 730-CCA auxiliary battery. On sale this summer.
Learn more about the Silverado SSV
2015 Tahoe is the Full-Size SUV Best Buy
The 2015 Chevrolet Tahoe proved to be one step ahead of the competition, scoring the editors' vote to become the Kelley Blue Book Full-Size SUV Best Buy for 20156. The Tahoe's all-new 355-hp EcoTec3 5.3L V8 engine provides more power and better fuel economy7 than any competitor.
Explore all the winning features
Chevrolet Colorado: Motor Trend's 2015 Truck of the Year®
In a rare unanimous vote, the Chevrolet Colorado was named Motor Trend's 2015 Truck of the Year®. With a best-in-class EPA estimated 26 highway mpg3, best-in-class towing4, best-in-class payload5, and a number of segment exclusive safety features, it's easy to see how the Colorado earned top honors.
Learn more
Introducing the all-new next-generation 2016 Chevrolet Volt.
The next-generation Chevrolet Volt features awe-inspiring technology that will amaze at every turn. Its stunning design and advanced safety features are paired with a more efficient dual-electric motor and a 1.5 SIDI high-efficiency engine allowing for a 50-EV mile2 driving range on a single charge. Coming fall 2015.
Explore the 2016 Volt
Drive into the future with the all-new Chevrolet Malibu.
With dramatic design, exceptional efficiency, and advanced technology, the all-new 2016 Malibu is the midsize sedan that has it all. The Malibu is expected to offer outstanding fuel economy with an estimated 37 mpg highway1, while the 2016 Malibu Hybrid takes efficiency even further with an estimated 48 mpg city1. Available late 2015.
Explore 2016 Malibu
Multiple Vincentric Wins for Buick
GM Fleet & Commercial strives to be your professional partner. It all begins by offering great products, and Buick's 2015 lineup of vehicles delivers. Vincentric, a leading firm that measures and analyzes the overall cost of owning and operating vehicles, has named multiple 2015 Buick models as Best Fleet Values.
View this year's winners
Fuel your business' success with the 2016 Bi-fuel Silverado 3500HD Chassis Cab.
Chevrolet is adding the 2016 Silverado 3500HD Chassis Cab to its long lineup bi-fuel of vehicles, including the Bi-fuel Silverado 2500HD and 3500HD and the dedicated CNG full-size Chevrolet Express vans. The Bi-fuel Silverado 3500HD Chassis Cab will give drivers the flexibility to use CNG or gasoline and will be available in both 2WD and 4WD drivetrains. It has a 24.5-gallon CNG tank, located directly behind the cab, and a 23.5-gallon gasoline tank that will give drivers optimal range between fill-ups. The Bi-fuel Silverado 3500HD Chassis Cab is an ideal option for businesses that not only want to improve their bottom line by saving on fuel costs, but also want a vehicle they can customize to suit their vocation. Coming late 2015.
Learn More


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Latest Sermon
Word of the Week
Luke 15:11-19
Covenant place:
God has made a covenant with you to bless you in a certain place.
Provided He finds you in that place you will prosper. Psa1:1-3
There is provision and protection in that place.
The devil's Master-plan:-
Is to make you bitter so that you move from your place of covenant.
He knows you are untouchable in that place.
You must do all that is within you to stay in that place. If you get out he will destroy you.
Order of Services
Main Sanctuary (Thika High Junction)
7:30 - 8:30 a.m... Prayers
8:30 - 12:00 noon .. Main Service
5:30 - 7:00 p.m... Prayers
Monthly Meetings
1st Sun ... Diamonds Meeting 2pm
3rd Sun ... Family Restoration Seminar 2pm
4th Sun ... Life Without Limits 2pm
Town Annex (Next to Jogoo House)
Monday to Friday
6:30 a.m - 7:50 a.m ... Morning Devotion
12:45 p.m - 1:50 p.m ... Lunch Hour Service
Sunday 9:00 am - 12:00 p.m ...Service
Upcoming Events
6th- 10th July 2015... Lunch Hours at Town Annex
Welcome to our Website
My wife and I believe that the grace and favor that God has bestowed upon our lives and ministry is not for us to admire and celebrate only with those associated with our ministry, but for the body of Christ to be build and strengthened by it as millions dare to believe God and step out to touch their generations.
As you browse through the pages of our website or connect with us through our twitter, facebook or visit our blog, our most sincere prayer is that you will be challenged and inspired to dare believe God to join the opinion shapers, market leaders and the climate changers of our time for that's who we are.
Bishop Titus & Jaminah Mbai. Co-founders
Pastoral Team
We have a strong team of dedicated Pastors who work closely with us to strengthen the body of Christ in Word, prayers and ministry across the destiny Network of Churches.
This team supports us throughout the seasons of life to administer the true Doctrine of the Gospel..
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E-Mail: firstname.lastname@example.com
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Website created and maintained by Crossgraphix. Email: firstname.lastname@example.com


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'Decent transfer speeds.'
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'It's available in several colors, including blue (80GB), red (160GB), and the silver 250GB drive I review here.'
'The built-in capacity meter allows you to view the utilized disk space.'
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Try 'Mobile Finder' - Android App by ReviewGist.
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How did three Danes end up being tortured in Lebanon?
The human cost of the Greek financial crisis
08 Oct 2013 14:40 GMT | Politics, Europe, US & Canada, Turkey, United States
Turkey has lifted a decades-old ban on headscarves in the civil service as part of a package of reforms by the government meant to improve democracy.
Tuesday's measure was hailed by Prime Minister Recep Tayyip Erdogan, whose wife wears a headscarf, as a "step toward normalisation" and came into effect after it was published in the official gazette.
"We have now abolished an archaic provision which was against the spirit of the republic. It's a step toward normalisation," Erdogan said in a parliamentary speech to his ruling party lawmakers.
"A dark time eventually comes to an end," he said. "Headscarf-wearing women are full members of the republic, as well as those who do not wear it."
The ban, whose roots date back almost 90 years to the early days of the Turkish Republic, has kept many women from joining the public work force.
Critics accuse Erdogan of lifting the ban to force his Islamic values on the majority Muslim but staunchly secular nation.
When plans to remove the ban were first announced last week, the main opposition party labelled it "a serious blow to the secular republic" created by modern Turkey's founding father Mustafa Kemal Ataturk in 1923.
Limited ban remains
Erdogan last week unveiled a package of democratic reforms mostly aimed at improving rights for minority Kurds, but he also used the opportunity to take on the highly controversial headscarf ban.
Female civil servants are now allowed to wear headscarves, while their male counterparts can sport beards. However, the ban remains in place for judges, prosecutors, police and military personnel.
Erdogan's ruling Justice and Development Party (AKP) pledged to remove the ban on the wearing of headscarves in all domains when it came to power in 2002. It has already relaxed the ban at universities.
The highly charged debate lies at the heart of Turkey's divisions between religious conservatives, who form the bulk of Erdogan's AKP supporters, and more secular members of society.
In 1999, Turkish-American lawmaker Merve Kavakci arrived in parliament wearing a headscarf for her swearing-in ceremony. She was booed out of the house and had her Turkish citizenship revoked.
In stark contrast, a day after Erdogan's announcement of reforms, President Abdullah Gul's wife wore her headscarf to parliament.
Source: AFP
Sweeping reforms announced by Prime Minister Erdogan are hoped to be an impetus for drafting a new constitution.
As Turkey's prime minister unveils a package of political reforms, we discuss the impact on the Kurdish peace process.
Politics, Turkey, United Kingdom
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Migrants complain of being sent to squalid shelters, as France unveils plan to reduce asylum processing times.
Europe, France, Migrants
Despite reforms, lifting of sanctions and 'opening', political activists in Myanmar continue to face arrests.
Human Rights, Asia, Myanmar
Changing climate, unpredictable rains dry out the land, threaten the pastoral way of life in Somaliland.
Poverty & Development, Environment, Africa
Tensions rise as Greeks from both side of the bailout debate take to the streets to withdraw money and express angst.
Politics, Europe, Greece
Voters say no to country's multi-billion euro deal with EU as PM Tsipras says creditors must agree to restructure debt.
Politics, Europe, Greece, European Union
US Secretary of State says "genuine progress" made in talks but US still "prepared to walk away" if terms unacceptable.
Politics, Middle East, Europe, Iran, US & Canada
From Democracy to the Market - we examine the devastating impact of the Greek financial crisis on ordinary citizens.
Business & Economy, Europe, Greece
Can Afghan archaeologists take on the Chinese and the Taliban to save a 5,000-year-old archaeological site?
Arts & Culture, Asia, Afghanistan
In war-torn Afghanistan it is not the Taliban that poses the greatest threat to women - it is their own families.
Human Rights, Women, Afghanistan
After decades of tension and hostility between the two nations, has change finally come to US-Cuba relations?


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The Incredible Story of Emma Edmonds, Civil War SpyIn 1861, when war erupted between the States, President Lincoln made an impassioned plea for volunteers. Determined not to remain on the sidelines, Emma Edmonds cropped her hair, donned men's clothing, and enlisted in the Union Army. Posing in turn as a slave, peddler, washerwoman, and fop, Emma became a cunning master of disguise, risking discovery and death at every turn behind Confederate lines
Where the Broken Heart Still Beats
The Story of Cynthia Ann ParkerAt the age of nine, Cynthia Ann Parker was captured in an Indian raid and taken to live as a slave with the Comanche. Twenty-four years later, she is the wife of a chief and the mother of a young warrior destined to become the great chief Quanah Parker. But in 1861 Cynthia Ann Parker and her infant daughter are recaptured, and returned against their will to a white settlement. "A skillful
A Novel of Patrick Henry's FamilyPatrick Henry, the famous statesman, has a secret: He keeps his wife in the cellar. Slowly losing her mind, Sarah Henry has become a danger to herself and her children. But daughter Anne has a secret of her own: She knows which child will inherit their mother's madness.Told from the point of view of the Henry children, this compassionate tale explores the possibility that Patrick Henry's immortal
A Story of the Boston MassacreIt's 1770, and fourteen-year-old Rachel Marsh is a servant in the Boston household of John Adams. But her loyalty to the Adams family is tested by her friendship with Matthew Kilroy, a British private with an unsavory reputation. Rachel knows Matthew is frustrated and angry, but even she is surprised when he is accused of joining soldiers in firing upon a mob of citizens . . . in the bloody
A Story of the American RevolutionSeymour Reit re-creates the true story of Will Knox, a nineteen-year-old boy who undertook the daring and dangerous task of transporting 183 cannons from New York's Fort Ticonderoga to Boston—in the dead of winter—to help George Washington win an important battle.
The Feud between the Hatfields and the McCoysFanny McCoy has lived in fear and anger ever since that day in 1878 when a dispute with the Hatfields over the ownership of a few pigs set her family on a path of hatred and revenge. From that day forward, along the ragged ridges of the West Virginia-Kentucky line, the Hatfields and the McCoys have operated not withing the law but within mountain codes of their own making. In 1882, when Fanny's


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Car Audio Security put on a great show despite the terrible weather that greeted us in the morning on arrival, all of the show kings and queens came out despite the rain and enjoyed a great day.
The show was sponsored by Airlift, Players, Meguairs and Kenwood.
Music used is hold on be strong vs big poppa (matoma remix)
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Sunset Cocktails and (free) Live Jazz
- Music
- 420 Park Avenue South, New York, NY, 10021
Arabic for Beginners
Idlewild's language courses are fun and practical, and were recently included in the "Best of New York 2012" issue of New York Magazine.
The classes are taught in our beautiful store, not a stuffy classroom, by dynamic and experienced native speakers. Class size is limited to 14, so everyone gets a chance to speak in every session.
Our new 15-hour Arabic class is taught by Mohamed Badr, a native of Egypt with more than 10 years' experience, including teaching at Berlitz and founding the Arabic language programs at CUNY and Yeshiva.
Is this class for you?
This course is designed for beginner students or those who have little background in Arabic. You will learn to read and write as well as pronounce and recognize the Arabic alphabet of Modern Standard Arabic. It is an introduction to the language including some common phrases, greetings and basic vocabulary as well as aspects of Arab culture.
In this course you will learn the structures and skills necessary to:
Because Arabic is more challenging for English speakers than the Romance languages we offer, including the learning of new sounds and a new way of writing, this class will meet a little longer than our regular courses -- for 90 minutes per week.
About our courses
If you wish to cancel your registration, you must contact Idlewild by telephone or email at least seven days before the start date of your class to receive a refund.
If you wish to postpone your registration to a later session, you must contact Idlewild by telephone or email at least three days before the start date of your class to receive a credit toward a future session (good for one year).
Idlewild is an international bookstore with locations in Manhattan and Brooklyn.
Our language classes were named "Best of New York" by New York Magazine and are taken by more than 3000 New Yorkers every year.
In order to purchase these tickets in installments, you'll need an Eventbrite account. Log in or sign up for a free account to continue.


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Route AA East Highway 15 Memphis, MO
FIRST CURTAIN CALL, says Don at Primrose Realty. This is the first time this 3 to 4 bedroom, 2 bath, home with 4 car attached garage has been on the market since it was built. This unique property consists of 10 more or less...view the listing
80 Acres on Clark County Line
Nicely located 80 acres, just a mile south of US Hwy 136 on the Clark County line. Approximately 70 acres of this is tillable with 20 plus acres of bottom ground. The assessor's records show 20 acres of class three, 23...view the listing
438 West Monroe
Beautiful three bedroom/two bath manufactured home located on the edge of Memphis, MO. This home is move in ready and it's features include living room with fireplace and antique mantle, dining room, nice eat-in kitchen,...view the listing
353 Green St. Memphis
New listing!!!Very nice two bedroom/one bath ranch. Located in a quiet neighborhood and very close to City amenities. Updated furnace and blown in insulation in attic. Home is in pristine condition and move in ready!!! Priced...view the listing
123 S.W. Santa Fe Ave Gorin, Mo. 63543
This would make a great place to stay when in the area hunting our abundant supply of wildlife. Home has been recently remodeled including a new roof. The property consists of an area of 8 city lots. Providing plenty of area for...view the listing
110 North Johnson Memphis, Missouri
PSSST, WANT A STEAL? This unique bungalow is priced so low you'll feel guilty about what you paid the poor seller says Cheryl at Primrose Realty. Basically 2 living quarters with private entries, one is equipped with...view the listing
Lake Thunderhead The Ultimate Getaway Destination
We sent Mark at Primrose Realty to check out this listing last week and he hasn't returned. He did call to say, "Bring more bait". Apparently the fishing is great from the dock and cove. There's a huge...view the listing
15337 Stokes RD, Green Top, MO 63546
GET A HORSE….You'll want several as the owner of this 40 m/l acre farm within commuting distance of Kirksville. The house has 1,744 square feet of country living, with a detached garage, 24 X 36 Shed & of course...view the listing


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General Enquiries Mob: +44 (0)77 7999 7867
Alistair and Csilla Tel: +44 (0)28 4173 9124
We have recently moved to: Top Floor, 16 Canal Quay, Newry BT35 6BP (above Cycle Recyle Cafe)
We are in the process of building a programme of classes and new classes will be added soon.
The studio is also available for hire to yoga teachers and alternative practitioners at reasonable hourly rates.
The Yoga Studio supplies all necessary mats and equipment and all you need to wear is loose comfortable clothing. If you wish to purchase your own mat please talk to us for advice first.
DROP IN CLASSES (PREBOOK or PAY AT CLASS or USE TICKETS)
All our General Classes are "Drop-in Classes" and pre-booking is not required, however if you book online with the "Book Here" Button your place is assured. The Drop-in price for these classes is £9.00 or you can buy tickets and save on the regular price. There may be a small booking fee for booking online.
For further information about any of the classes or tutors click on the links below
BEGINNERS CLASS: (Drop-in or Tickets)
WEDNESDAY 7.30 - 9.00 pm with Csilla Toldy
GENERAL YOGA CLASSES (Drop-in or Tickets)
MONDAY 6.00 – 7.30 pm Not available at present.
TUESDAY 10.00 – 11.30 am with ALISTAIR LIVINGSTONE
TUESDAY 6.00 – 7.30 pm with ALISTAIR LIVINGSTONE
FLOW YOGA (6 Week Block of Classes)
Not currently available
YOGA FOR PREGNANCY (Drop-in or Tickets)


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General Bonus Terms and Conditions:
The following terms from part of the Terms and Conditions of use at www.OptionFair.com – (Sections 25.1-25.9)
To be eligible to receive a bonus or promotion from the Company, you must have made a minimum deposit of 250 USD/EUR/GBP.
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For Forex trades the wagering amount attributed to a trade is calculated as follows: Initial Investment Amount x Trade Leverage / 500
Notwithstanding Point 4, bonuses exceeding $ 4,999 and $ 9,999 shall be subject to trading volume requirements of 60 times and 80 times the value of the bonus before becoming available for withdrawal.
In the event that the entire or part of the deposit on which the bonus is given is withdrawn before the bonus amount has been traded 40 times, the following shall apply:
- The bonus shall be canceled.
- In the case of trading loses, all losses will be borne by the original deposit and the remaining balance may be withdrawn.
- In the case of trading profits, the trading profits shall be canceled and the original deposit may be withdrawn.
Bonuses which are awarded as "Broker's Money" shall be available for withdrawal after trading 10 times the volume of the bonus value. All other conditions described in sections 1-6 apply.
Risk Free/Insured Trades- For any 'risk free/insured trades', all participating users understand that in the event of a trading loss, OptionFair will reimburse the trader with bonus funds to their account balance. The value of the bonus is determined by the total loss from all insured trades and will in no event exceed the value of the funding deposit. If at any point a trader withdraws the initial deposit amount from their account, OptionFair reserves the right to cancel the 'risk-free/insured trades' offer and all losses will be deducted from the account of the user.
Cashback is a cash payment reward. Cashback is a promotional offer that is subject to change. OptionFair reserves the right to alter or cancel the terms of the cashback promotion without prior notice and without explanation. Any decisions are final. The requirements to qualify to receive cashback may vary for different promotions.
The Company reserves the rights to change or cancel any bonus or promotion at their discretion.


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Fred Peck, DDS
About Fred Peck, DDS
Show More Fred Peck, DDS practices in Cincinnati at Fred H. Peck, DDS as a Cosmetic Dentist. Dr. Peck began participating on RealSelf in 2011, and has achieved "Participating Doctor " status. The doctor has 29 years of experience providing cosmetic and aesthetic medical services, and is a member of American Academy of Cosmetic Dentistry (AACD). Dr. Peck has hospital affiliations at Jewish Hospital Cincinnati.
Consultation Fee
Free. Inital consultation to discuss patients cosmetic and oral health issues.
Treatments offered at Fred H. Peck, DDS
Education / Training
Dental: DDS, Ohio State University College of Dentistry
There is no recent activity.


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This USA made by hand His and Hers Titanium Ring Set is one you wont want to pass up! This Modern Design of the Infinity Symbol is milled right on top of these rings, making this set one you will Cherish for a lifetime! The Men's Ring is 9 mm wide, and the Women's is 7 mm wide. Both are Polished, and have Sizing 4-17 in whole, half and quarter size increments!
New Infinity His and Hers Set Titanium Wedding Rings: 9FP.7FP-T1-INFINITY
- Handmade item
- Material: titanium
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- Ships worldwide from United States
- Feedback: 3123 reviews
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- Listed on Jul 2, 2015
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The Art and Science of TeachingASCD 2007; US$ 26.95
The popular author of Classroom Instruction That Works discusses 10 questions that can help teachers sharpen their craft and do what really works for the particular students in their classroom. more...
Assessment and Student Success in a Differentiated ClassroomASCD 2013; US$ 26.99
A dynamic look at assessment and grading through the lens of differentiated instruction. more...
You've Gotta ConnectIncentive Publications 2014; US$ 14.99
Demonstrates how to build a strong student-teacher connection in the classroom. A secure and trusting relationship between teacher and students is at the heart of positive discipline and a safe, productive classroom. The positive effects of building teacher-student relationships impact all aspects of classroom life. Students come to class and like... more...
The Handbook for Enhancing Professional PracticeASCD 2008; US$ 27.95
Ready-to-use forms and instruments offer sound advice and step-by-step procedures for how teachers and other school staff can incorporate the framework for professional practice into their work. Includes guidance and tools for evaluation by self, mentors, and supervisors. more...
Holding On to Good Ideas in a Time of Bad OnesHeinemann 2009; US$ 24.38
Holding On to Good Ideas in a Time of Bad Ones is for teachers who struggle under top-down mandates or are forced into scripted reading lessons?whose humane, sensitive ways of teaching are threatened by rigid, mechanical programs. Tom Newkirk eloquently defends teaching against the ?cult of efficiency? that turns classrooms into assembly lines of knowledge.... more...
Jumpstart! ICTTaylor and Francis 2013; US$ 24.95
@text:John Taylor jumpstarts pupil and teacher enthusiasm for ICT learning with this refreshing range of simple to use activities, games and creative lesson starters. Encouraging and developing creative uses of basic ICT software, Jumpstart ICT widens teachers? horizons, bringing ICT to the fore as an exciting resource and classroom tool. Key... more...
Response to Intervention, Second EditionGuilford Publications 2011; US$ 39.00
This bestselling work provides practitioners with a complete guide to implementing response to intervention (RTI) in schools. The authors are leading experts who explain the main components of RTI--high-quality instruction, frequent assessment, and data-based decision making--and show how to use it to foster positive academic and behavioral outcomes... more...
Geschichte des Instituts f�r Pathologische Physiologie an der Universit�t LeipzigFrank & Timme 2015; US$ 43.90
Die Physiologie, die Lehre von den Funktionen im gesunden Organismus, wird an der Universit�t Leipzig seit 1531 an der Medizinischen Fakult�t gelehrt. Die Gr�ndung des Instituts f�r Pathologische Physiologie als ?Tochter? des Physiologischen Instituts war die konsequente Folge der zunehmenden Physiologisierung der klinischen Disziplinen in Diagnostik... more...
Scaling Up SuccessWiley 2015; US$ 50.00
Drawing from the information presented at conference sponsored by the Harvard Graduate School of Education and the Mid-Atlantic Regional Technology in Education Consortium, leading educators, researchers, and policymakers, Scaling Up Success translate, theory into practice and provide, a hands-on resource that clearly describes different models for... more...
Counseling Skills for TeachersSkyhorse Publishing 2015; US$ 14.99
By necessity, today's teachers do much more than deliver instruction. In the classroom, on the playground, or even in the parking lot, teachers are often called upon to respond quickly and appropriately to students' social and emotional needs, drawing from instinct more than anything else. In this second edition of the bestselling Counseling Skills... more...


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He spent 19 years terrorizing NFL quarterbacks and embarrassing their blockers, but now he fills that need for competition by attacking a little white ball.
Unlike many other retired superstars, Bruce Smith is basically content with life after football. The 46-year-old spends his days relaxing with his wife, Carmen, and 15-year-old son, Alston, while trying to lower his 10 handicap by playing 18 holes with pals Darren Perry and Darrin Hyman. But it's not all play; he works with such charities as Norfolk-based Operation Smile and develops real estate projects such as the just-opened Smith's Landing off-campus apartments next door to his alma mater, Virginia Tech.
Smith's eyes light up when he discusses the development that replaced the hotel where he stayed during his 1980 recruiting visit to Blacksburg, Va. The NFL's all-time sack leader still works out regularly at his home or at nearby Bayside Wellness and Fitness Center to maintain his playing weight of 273 pounds on his 6-foot-4 frame. But he's just as passionate about watching a family of hawks nesting on the pier that juts into the Lynnhaven River from the expansive deck of his Virginia Beach mansion.
Only the Aug. 27 appeals hearing on the suspension of his driver's license following his third DUI arrest since 1997 casts a shadow over the life of Smith, who will be inducted on Saturday into the Pro Football Hall of Fame in his first year of eligibility.
"I didn't want to leave this area for a number of reasons," said Smith, who grew up geographically close, in Norfolk, but economically in a different world. "My mother and Carmen's parents were here. The cost of living is relatively moderate. We have great weather at least eight months of the year, and you still get the four seasons. I had a relationship with [Virginia Beach development firm] Armada Hoffler. I have the opportunity to see nature at its best. Anytime I want to go out back, drop a line in the water and catch some fish, I'm able to do that. There are tons of crabs back there and an oyster bed. It's the best of all worlds."
Smith's world changed radically when he retired after the 2003 season, having finally surpassed the late Reggie White with his 199th sack. From the time the Buffalo Bills made him the top overall selection in the 1985 draft through his final four years closer to home with the Washington Redskins, Smith's mission was to get to the quarterback. He arguably did that better than anyone else. But out of football at 40, what he was going to do?
Fortunately for Smith, he had met Dan Hoffler, chairman of Armada Hoffler, at an Operation Smile fundraiser in 1993 - the year Smith's Bills made the last of four straight Super Bowl appearances - and became an investor in the firm in 1995.
"We talked a little bit about what he wanted to do, how he wanted to move forward and I recognized Bruce's business acumen right off the bat," said Hoffler, sitting in his expansive 21st floor office, a few steps from the much smaller workspace Smith maintains as the president of Bruce Smith Enterprises. "The real estate business to a large degree is about your instincts, and Bruce's instincts about locations and the types of deals that will work or won't work are extremely good.
"Bruce has a combination of instinct and intelligence. Not everyone possesses that. That's why you see so many guys who get out of the game and can't move forward. They go backward. Bruce has moved forward."
But Smith, who wears expensive suits and carries a Louis Vuitton briefcase in his business dealings, hasn't fully moved on from football. Nor has he gotten too far from the working-class teenager who reached Booker T. Washington High School with rare athletic gifts - he could outrun teammates who weighed 40 pounds less, and he won the state wrestling title in between games of the state basketball tournament - and the desire to become a superstar.
At Booker T. Washington, Smith brought coffee cans filled with concrete to school to show his skeptical basketball teammates the importance of weightlifting. On the court, the superb rebounder and defender made sure that no one messed with his teammates. That was also true on the football field, but in a different way. Coach Cal Davidson wouldn't let Smith take part in most contact drills as a prep senior out of fear that he would injure his teammates.
Today, there's an alcove in Smith's home where he displays many of the awards he accumulated in the NFL. His helmets from Virginia Tech, the Bills and Redskins sit alongside autographed headgear from such admired opponents as Dan Marino, Eric Dickerson and Derrick Thomas. Downstairs, autographed jerseys of legends White, Joe Montana and Magic Johnson as well as those of Bills teammates Jim Kelly, Thurman Thomas, Cornelius Bennett and Darryl Talley line the walls along with large mementos of the record-breaking 199th sack.
"Some people get the wrong impression about Bruce," said Perry, a native of nearby Chesapeake, Va., who played nine NFL seasons and now coaches the Green Bay Packers' safeties. "They see arrogance, but most successful people have some arrogance. Bruce has toned down from when he played, but if you don't respect him, he's going to let it be known."
While Smith said he gives Alston football advice only when asked, he often attends his 6-3, 225-pound son's practices at Cox High School, where Alston plays defensive end and offensive tackle.


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That people feel wealthier from spending money on others may explain why poor individuals tend to give away a higher fraction of their income than members of the middle class do. In one study, researchers reported that Americans earning less than $20,000 a year give a higher percentage of their income to charity than others earning up to $300,000 a year.
"Our results suggest when the poor give money away, that very act might mitigate their feelings of poverty," Norton says. "More broadly than this specific benefit, our investigation contributes to the growing body of research documenting the benefits of prosocial behavior, which include greater happiness, reduced mortality, and better immune function."
Buying experiences to feel happy
In related research, psychologists are finding that spending money on experiential purchases, such as vacations, concerts, and meals out, tends to bring us more happiness than material purchases, such as clothing, jewelry, or electronic gadgets. Amit Kumar and Thomas Gilovich of Cornell University are investigating one potential explanation for this difference: that experiences prompt storytelling more than possessions do.
In new research, they asked participants to recall either a significant experiential purchase or a significant material purchase. They then asked them how much they had talked about the purchase they recalled, and questions related to the satisfaction they derived from their purchase. Participants rated a higher satisfaction for experiences than for possessions, which was because they were more likely to talk about the experiences with other people.
In another experiment, the researchers measured what happens when people cannot talk about their purchases. They asked particip
|Contact: Lisa M.P. Munoz
Society for Personality and Social Psychology


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Algonquian Tribes | Climate | Communities | First Nations | History | Home | Migrations | Reservations | Sitemap | Tribes
The Republic of North Amazon
Chippewa Indians for a Rebirth of the Chippewa Nation
Your financial support is needed. It is the Seven Fires Prophecy that foretells of a Rebirth of the Chippewa Nation. Our goal is to unite all Chippewa Reservations and Reserves in Canada, Mexico, and the United States. You can donate money by using paypal. Below is the paypal button. Donate any amount of money. If you are in fear of white terrorism, don't join our organization. Just donate money. If you are not in fear of white terrorism, click the Chippewa Indians for a Rebirth of the Chippewa Nation link below. It is a facebook page. This is from Samuel Poe. Also email me if you rather another route be a token.
Chippewa Indians for a Rebirth of the Chippewa Nation
Algonquin News
January 20, 1823 - March 8, 1824 Siege of Montevideo
Considered by historians to have been a battle of the Brazilian War of Independence, the Siege of Montevideo was just another battle between the Anishinabe Army and army of the white confederation led by England, for control of South America. This battle was fought in Montevideo or Cisplatine, Brazil. It was a part of the Anishinabe military campaign to bring Brazil under their control. For well over 1 year, Anishinabe soldiers laid siege to the unwanted white city. By March 8, 1824, they forced the whites to hand the city over to them. Afterwards, the victorious Anishinabek took control of the city and probably killed all within the settlement. White soldiers numbered over 4,000 in this long siege, while Anishinabe soldiers numbered over 3,000.