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12-pounder Confederate bronze field howitzers #1569 - Chickamauga National Battlefield
in Static Artillery Displays
This 12-pounder Confederate bronze field howitzers is near the marker to Culpeper's South Carolina Battery and is located at the south end of Poe's Field on the east side of Lafayette Rd, Chickamauga National Battlefield.
posted by: Lat34North
location: Georgia
date approved: 4/5/2012
last visited: 3/2/2011
E0 km
Culpeper's South Carolina Battery Marker - Chickamauga National Battlefield
in American Civil War Monuments and Memorials
This marker to Culpeper's South Carolina Battery is located at the south end of Poe's Field on the east side of Lafayette Rd, Chickamauga National Battlefield.
date approved: 4/6/2012
in Specific Veteran Memorials
in NRHP Historic Districts - Contributing Buildings
SE0 km
Culpeper's South Carolina Battery Tablet - Chickamauga National Battlefield
This plaque to Culpeper's South Carolina Battery is located at the south end of Poe's Field on the east side of Lafayette Rd, Chickamauga National Battlefield.
12-pounder bronze Napoleons #144 - Chickamauga National Battlefield
This 12-pounder bronze Napoleons is near the marker to Culpeper's South Carolina Battery and is located at the south end of Poe's Field on the east side of Lafayette Rd, Chickamauga National Battlefield.
NW0 km
Forty-Fifth Tennessee Infantry Regiment Marker ~ Chickamauga National Battlefield
The 45th Tennessee Infantry Regiment Marker is located in Poe Field on Lafayette Road. The 45th Tennessee occupied this position at 11:30 A.M. Sept. 20, 1863.
date approved: 7/27/2014
Eighteenth Tennessee Infantry Regiment Marker - Chickamauga National Battlefield
The 18th Tennessee Infantry marker is located in Poe's Filed near the Georgia State Monument on the west side of Lafayette Road in the Chickamauga National Battlefield.
date approved: 3/13/2012
S0 km
Georgia State Monument - Ft Oglethorpe, GA
in Smithsonian Art Inventory Sculptures
One of many monuments located in the Chickamauga Chattanooga National Military Park.
posted by: ChapterhouseInc
date approved: 10/27/2009
last visited: 9/30/2014
State of Georgia Troop Memorial at Chickamauga
State of Georgia Monument at Chickamauga Battlefield.
posted by: NickTnReb
date approved: 5/25/2008
Georgia Monument - Chickamauga National Battlefield
The State of Georgia Monument to those from this state who participated in the battle that raged throughout these fields.
date approved: 7/22/2009
Georgia Monument Soldiers - Chickamauga National Battlefield
in Figurative Public Sculpture
date approved: 7/20/2009
SW0 km
Clayton's Brigade (CSA) Plaque - Chickamauga National Battlefield
The Clayton's Brigade Plaque is located in Poe's Field on Lafayette Road. The plaque describes the action on Sept. 20, 1863 at 11 A.M.
date approved: 12/9/2014
date approved: 12/6/2014
in Signs of History
date approved: 12/5/2014
W0 km
Darden's Mississippi Battery (CSA) Plaque - Chickamauga National Battlefield
The Darden's Mississippi Battery is located in Poe's Field on Lafayette Road. The plaque describes the action on Sept. 20, 1863.
SW0.2 km
Brown's Brigade (CSA) Plaque - Chickamauga National Battlefield
The Brown's Brigade Plaque is located in Poe's Field on Lafayette Road. The plaque describes the action on Sept. 20, 1863 at 11 A.M.
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Around the world one plate at a time
Chef Justine Lindsay has cooked for British royalty and Formula One champs, writes Lauren AnthonyRead Story
LesDaChef owes his popularity to social media
LesDaChef is not your average South African food blogger. He is male, a proper chef and hails from Johannesburg, not Cape Town. He spoke to Nontando MposoRead Story
Video: diet changes boy's life
Eight-year-old Dylan Massam was diagnosed with ADHD two years ago. This little boy's life has chaned for the better, after his mother changed his diet. Hi... Read Story

subset: commoncrawl


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Why Not to Build a Homegrown SOA on Your Own
from http://jroller.com/page/bsnyder?entry=why_not_to_build_a
As someone who did build a homegrown SOA back in 2004 for a client, I can tell you it's not as easy as it seems - what really is easy is to do is make mistakes. I'm not talking about minor mistakes, but major architectural issues that won't be apparent immediately but can plague a system for years to come. A homegrown SOA is fine for a SMB, but for a large enterprise a solid architecture that allows for easy future expansion is important. I was recently at a client who began to build their own SOA using JMS and this is most definitely the right way to go. I applaud the guy who designed this architecture because it allows other systems to be loosely integrated, especially over time. This is a very good first step.


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Wait Wait... Don't Tell Me!
Wait Wait... Don't Tell Me! is a fast-paced and irreverent quiz show that tests your knowledge against the best and brightest in the news and entertainment world.
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BONUS: Paula Poundstone Discovers the Selfie Stick
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WWDTM continued to look back at the year 2014, plus we play highlights of Carl's last shows before he became Scorekeeper Emeritus.
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Comedian Jenny Slate joins us along with panelists Paula Poundstone, Maz Jobrani, and Roxanne Roberts.
Sir Patrick Stewart
Actor Patrick Stewart joins us along with panelists Charlie Pierce, Shelby Fero, and Tom Bodett.


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Clinton: American Experience
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Airs Tuesday, May 8, 2012 at 8:00 p.m. ET/PT. Check your local listings. 00:31
Clinton | American Experience | Battle over the...
Clinton's "triangulation" strategy was an attempt to take control of the budget from the Republicans in Congress.... 02:58
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When Bosnian Serb soldiers murdered thousands in July 1995, Clinton initiated a massive NATO military response. "He... 03:01
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After the Oklahoma City Bombing, Clinton's ability to reach Americans on a personal level did much to help the... 02:54
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Average Customer Review
Share your thoughts with other customersCreate your own review
2 of 2 people found the following review helpful
5.0 out of 5 stars Double Time Capsule
Time and Again is highly entertaining and appealed for many reasons. It was a chance find as I had no idea Finney was the author of The Body Snatchers and other works. He lived in New York and wrote advertising copy for many years - one of the agencies he worked for was Dancer-Fitzgerald-Sample. This novel was written in 1970 and its protagonist, Simon Morley, must be an...
Published on Nov. 3 2011 by Jeffrey Swystun
3.0 out of 5 stars If you love historical detail, you will love this
I waited for this book to deliver, and I waited.
The author gives more than enough detail about old NYC, which is great if you enjoy imagining NYC before the Statue of Liberty stood tall. The story is good, and but loses its zest with an overkill of the obvious. This 400-page book could have been written in 300.
Also, this story is simply dated. The author...
Published on Aug. 3 2003 by George
Most Helpful First | Newest First
2 of 2 people found the following review helpful
5.0 out of 5 stars Double Time Capsule,
Jeffrey Swystun (Toronto & Mont Tremblant) - See all my reviews
This review is from: Time and Again (Audio Cassette)
Time and Again is highly entertaining and appealed for many reasons. It was a chance find as I had no idea Finney was the author of The Body Snatchers and other works. He lived in New York and wrote advertising copy for many years - one of the agencies he worked for was Dancer-Fitzgerald-Sample. This novel was written in 1970 and its protagonist, Simon Morley, must be an avatar of Finney's as he works in advertising on Madison Avenue. Possessing certain qualities unknown to himself, Morley is recruited by the U.S. government for a time travel experiment. The method of time travel is original. Morley and other recruits study the history, culture, and landmarks of their time destination and then travel using an intense form of self-hypnosis.
Morley ensures that his time and place is 1882 in New York City so he can investigate a certain mystery. Finney's wonderful descriptions of the city in the late 19th century are alone worth the read. Yet, he delivers with a tale that has great twists and turns and a palatable, endearing love story. As it was written in 1970, the New York of that period is also brought to life so that the book offers a double time capsule. Lastly, given my stint on Madison Avenue, I loved the references to the advertising profession (both in 1882 and 1970) and how J. Walter Thompson factors into the story.
4.0 out of 5 stars SILLY BUT GREAT FUN,
This review is from: Time and Again (Paperback)
Having been intensively coached in passing himself off as a nineteenth century New Yorker, the first thing our time-travelling hero does on arrival is to demand to know why there are no traffic lights in the city- way to avoid attracting unwelcome attention! I enjoyed this book very much but OK it's a bit silly at times. I would have liked a little bit more "science" around the time-travel (vague references to Einstein and hypnotism are not very convincing). A number of points are well made, eg we won't learn much about the past from looking at worn-out artifacts as obviously they looked completely different when new.
For some reason (maybe because he was writing nearly 50 years ago) the author does not always express himself in the most politically correct terms, so high minded types might want to avoid this book.
The time-traveller's jumping-off point is the New York City of the late 60's, the city familiar from the Clint Eastwood film Coogan's Bluff. Remember the bit in the movie where Clint is looking at the New Jersey cliffs and tries to imagine what it was like before there were any people? There is an almost identical scene in Time & Again. There are also some other weird resonances between the movie and the book- which is a bit of a mystery in itself.
5.0 out of 5 stars An intensely vivid time travel,
The Curious Dame (Canada) - See all my reviews
This review is from: Time and Again (Paperback)
Time and Again is a fascinatingly unique book written by bestselling author, Jack Finney (1911 to 1995). Originally released in 1970, it is a time travel / romance complete with photographs and drawings. It tells the story of a man by the name of Simon Morley who is recruited for a top secret experiment - to travel back in time to New York City in the year 1882. But this is no regular time travel tale. Rather, what you will read is an amazingly detailed recreation of life as it was in the New York of 1882. From fashion to landscape, from societal norms to politics, never before have I read a book with such intensely vibrant details. Into the storyline, numerous photographs and drawings are provided and described through the eyes of Simon. I thoroughly enjoyed looking at the antique photographs of the characters.
The plot is interesting and well planned, and although the intense descriptions slow the pace of the novel, the rich writing and descriptions truly make this story play like a movie in your mind, making the characters real, larger than life. This story is alive and with lovely flowing simple prose, it is a story that truly does pull you back into 1882. The time travel storyline is entirely credible and realistically believable. It is easy to see why this book has become a beloved classic.
If a visit to New York city has always been your dream, read this book to get to know the city. If you have visited New York city before, read this book to bring back memories of your trip. And if you live in New York, read this book to experience the historical growth and vibrancy of this city in a gentler era.
5.0 out of 5 stars A One-of-a-Kind Book,
loblollyboy (Vancouver, Canada) - See all my reviews
This review is from: Time and Again (Paperback)
To get it straight at the start, Jack Finney's novel Time and Again is not a great work of literature; it's an amiable and charming, if peculiar, rather lightweight hybrid of at least three genres--the mystery/spy/government-conspiracy novel, the historical romance and the nostalgic travelogue, with a short bow in the direction of science-fiction. It is not a definitive novel of time-travel; its method of changing eras is not far from squeezing your eyes really tightly together and tapping your heels together three times, though the theoretical basis is just a smidgen sounder than for Dorothy in Oz. It is not a great romance, though it is romantic. It is not even science fiction--well, okay, okay, to be kind, Finney's straight-faced use of Relativity theory allows it to barely squeeze under the fence into the field. Its plot is flimsy, with more holes than the Detroit infield, and some of its characters are mostly cardboard cut-outs to be moved here and there by the stage-hands moving the plot along. And you know what? I loved every silly, odd, funny, charming, implausible, exciting, interesting, occasionally poignant page of it.
Why? Because rarely will you find a book where it's so obvious that the author had as much sheer fun writing 'Time and Again' as you'll have reading it. His protagonist, Simon Morley, keeps using words such as 'excited", "pleased" and 'glad' and phrases like "happy to be here" throughout the book, the book is full of happily excited people, and it's clear Morley's a fictional rubber-necking time tourist through which Finney has the time of his life swanning vicariously around the now-vanished hotels and theaters and civic buildings of Old New York. It's more than just travelogue, though. Finney was able to catch the details of day-to-day life for all these now-vanished people, known to us now only by old sepia photographs and antique knickknacks and a few old buildings which have escaped the demolishers. But then, it was their world, as familiar as ours is to us: that's where they lived their lives. Well, we'll be known the same way one day, after all--our day-to-day is going to be someone else's history up ahead, and in 'Time and Again', everyone wonders and asks Morley, what was it like, back then? what was it really *like*?
As a science-fiction author, Finney never showed all that much interest in the future but was fascinated with and nostalgic for the past, in particular what came to be called 'The Good Years' for America and the industrialised world, a golden-afternoon period of increasing world prosperity based on accelerating technological progress and an uncrowded world at relative peace, its resources yet to be depleted--at least for the burgeoning middle-class and higher--beginning about 1880 and coming to a calamitous end in 1914. Through 'Time and Again' and his other time-travel novels and stories, it's clear that Finney mourned the loss of that world (as who wouldn't?), seeing the First and Second World Wars as hideous deviations from humanity's real path, one that we resumed, too briefly, between the late 1980's and September 11 2001.
That the past and its people actually existed and still exist somewhere to be visited is a theme throughout much of Finney's short stories. His collection, 'About Time', collects a number of overtly time-travel stories, and another, 'I Love Galesburg in the Springtime', contains the nifty eponymous time-travel story as well as other science fictional themes). Besides 'Time and Again', at least two of his novels are explicitly about time-travel: its darker sequel, 'From Time to Time', which contains a chapter, in the opinion of this unworthy one, which is alone worth the price of the book, mostly just a front-porch conversation between several people on a hot New York summer evening, it's a loving evocation of daily life in the wide community of vaudeville performers and just may have been the best single piece of writing that Finney ever did, and an out-of-print novel called 'Marion's Wall', a lovely, funny ghost story in which a silent-movie queen who died relatively young comes into the lives of a modern (1970's) Hollywood couple--in it, Finney evokes the Silver Screen era as it impinges on, and occasionally collides with, the modern day.
The plot of 'Time and Again' revolves around-- nawwww, it's really not that important. Really. Just go read the book. As long as you don't demand it to be Great Literature, you'll have a great time. And, like me, you'll probably recommend it to everyone you know as a 'Hey, ya gotta read this!' book, and re-read it yourself from time to time. Enjoy!
5.0 out of 5 stars A classic of time travel, romance, and history,
Claude Avary "West Coast Reader" (Los Angeles, CA USA) - See all my reviews
This review is from: Time and Again (Paperback)
Author Jack Finney (1911-1995), among his other writing accomplishments, penned two great, influential science-fiction novels: the 1955 alien invasion story "The Body Snatchers," the source for three great movies (with "Invasion of..." usually tacked onto the front), and this 1970 subtle romance about time travel. It's a novel that many people hold close to their hearts, and like the movie "Somewhere in Time," has the magic to allure you with the wonder of traveling back to a simpler time -- 1880s New York in this case -- and exploring in depth a world so unlike your own. Finney, with meticulous detail and the support of numerous old photographs and drawings from the period (this is referred to as an "illustrated novel") recreates New York in 1882, letting us and the main character, Si Morley, marvel as we walk over the old streets, see places where one day great skyscrapers will stand, gaze on a traffic jam of hansom cabs, discover the arm of the Statue of Liberty sitting in Madison Square awaiting the rest of its body, play old parlor games in a boarding house, and look at Fifth Avenue when it was a thin street of trees and apartments. People who have lived in New York will especially adore these decriptions of the vanished city and the comparision Finney makes between the "modern" city (1970; vanished now to us as well) and the 1880s city. However, even if you've never been to New York in your life, you'll feel like you have after reading this. That's an incredible compliment to pay to a writer.
"Time and Again" won't please readers looking for quick action and thrills. It is a leisurely book that takes its time to build up the central situation: the U.S. government has found a possible method to travel back in time through purely mental means, and believes that young artist Si Morely fits the profile of the person who can achieve it. Once the books moves to the actual time traveling, the focus is mostly on the experience of being in another time and Si's discovery of how it affects him...especially when he feels he may be falling in love with a girl from the time. There is, however, a mystery simmering inside the story, and Si sets himself out to unravel it. What will the consequences be for history itself if he interferes? And what does the government really want to achieve with this project?
The last third of the book is tense and suspenseful, and contains an incredible and lengthy description of a disastrous event that ranks with the most vivid visual writing I've ever read. And the resolution is nothing short of perfect; Finney delivers the most satisfying conclusion. However, the book takes patience. Let Finney's prose, his wonderful main character Si, and his ability to pull you back in time with him sweep you away -- you won't regret it when the journey is over. Even if you never read science fiction or claim to dislike it, this is one book you'll find it difficult not to fall for.
4.0 out of 5 stars How does one follow 118 reviews? With a twist..,
"douglasnegley" (Pittsburgh, Pa. United States) - See all my reviews
This review is from: Time and Again (Paperback)
Let me say first of all that I loved this book. Let me say secondly that I do not like New York City very much. No matter - Jack Finney, for all his writing faults, creates a viable and enjoyable time travel story. Jack Finney also shows himself to be somewhat of a bigot, but that didn't bother me either - hey, Hemmingway was an alchoholic, but that isn't why I don't like much of his work. Finney's description of old New York City in 1882 was, to me, thoroughly enjoyable. I would live there whereas I would never live in what it is now. In 50 years, if we're still here, I think Finney will be seen as a kind of visionary - because I believe that time travel can be (is) a reality...and I think his theory on how to do it is not that far off. I believe that DNA is far more powerful than we know. I also believe that, in our subconscious, we can access the memories of our past, given the proper stimulus, state of mind, and location - so to me the storyline is not at all farfetched. Yes, the plot itself has a few flaws. For instance, why did Si and Julia not simply go back to the room at the Dakota when they were being hunted. This book is not meant to be a heavy read. It is meant to be fun - and it is. Different strokes for different folks, I suppose, judging by the vehemently differing opinions on the value of this best seller. I read very few fiction books, but this one I would recommend. It actually inspired me to write a time travel novel of my own.
3.0 out of 5 stars If you love historical detail, you will love this,
George (Richmond, Virginia) - See all my reviews
This review is from: Time and Again (Paperback)
I waited for this book to deliver, and I waited.
The author gives more than enough detail about old NYC, which is great if you enjoy imagining NYC before the Statue of Liberty stood tall. The story is good, and but loses its zest with an overkill of the obvious. This 400-page book could have been written in 300.
Also, this story is simply dated. The author uses the language of the 1950's calling women with jobs "office girls" and African Americans "Negros." The book was published in 1970, and thus pre-dates the Twin Towers, the murder of John Lennon at one of the book's most significant landmarks, The Dakota.
But that does not excuse another annoying problem: story holes. For instance, the military combs through all its records to determine that our protagonist has the "right stuff" for time travel. One character in particular, Rube, envies our leading man, Si, for his good luck in being selected for time travel. This implied to me, at least, that Si has a rare composition that might predispose him for greatness.
A short time later, Si's girlfriend proves equally able, on a whim, to travel with him on an excursion back in time, and by allowing her to join him, Si proves himself quite ordinary.
Thus, for me, the the story became contradictory, hollow and strained.
While enjoyable, Time and Again fails to live up to its potential. The author barely addresses the ramifications of time travel and over indulges in historical and romantic descriptions. Others have found this book magical. I enjoyed it, but I was not carried away with its charm.
4.0 out of 5 stars Great concept, somewhat dissapointing execution,
ultra-ralphus (conneaut, OH USA) - See all my reviews
This review is from: Time and Again (Paperback)
I enjoy time travel books and have read a number of books about time travel from authors as varied as Mark Helprin, Gene Wolf, Jorges Borges, Italo Calvino, William S. Burroughs, Martin Amis, Salmon Rushdie, and Gabriel Garcia Marquez. That being said, this Jack Finney novel fascinated me with its original (to me anyway) approach to time travel. I was delighted as he methodically laid out his method of time travel and I found it to be a very fun and charming. If you are intrigued by old New York or time travel, I suspect this book will be a very enjoyable read.
The fantasy aspect is done in such a way that the book seems almost a work of magical realism but the execution (referring to writing style) is very different than that of any magical realist authors I am familar with. In some ways the writing style is very obsessed with detail. The brick by brick description of the city works very well within the framework of the novel at times, but there are other times that it clearly detracts from the momentum and readability. The dialogue is a bit rough and awkward most of the time but not so much that it ruined the novel (it was still a fun read). The reactions of the characters to events and each others' statements was awkward and reminiscent of pulp writers of the 70s. By that I mean that the actions, choices, statements of the characters seemed very contrived at times. The author knew which way he wanted the events to go, and Finney manhandles his characters to make sure they do and say the correct things in order that plot proceeds as planned. This happens often without regard for previous character development or common sense.
Overall, I didn't regret reading the novel in fact it was a page turner, but I really would like to see a higher caliber writer approach this type of time travel because I felt that some limitations of Finney definitely detracted from the book's success. In music one band will often "cover" a song from another band. Reading this novel I couldn't help but wish that Helprin or Rushdie or some other great writer would do a "cover" of this book.
5.0 out of 5 stars One of my favorite books,
This review is from: Time and Again (Paperback)
I always recommend this book to people. I love it.
I love the description of NY history and the details of it. I'm from New York and, after reading some of the other reviews, I see that the details were less interesting to other people. But, elements such as: Trinity Church was the tallest building, City Hall was "uptown" (I love these!), The Statue of Liberty's head was visible but unassembled - I was lost in the scenery, what NY was like, and riveted by the history.
When I started to read the book, I thought Finney bit off way more than any book can chew: a time-travel, love story, historical fiction, mystery all in one - ha, this guy is full of himself. Then I kept reading. He pulled it off famously. I was taken in and absorbed, riveted. New York then. The story - I was swept away. The intrigue - a page turner.
I simply love this book. I adore it. I loved reading about this time period in NY, about places I know now, and with the story and style used. Just wonderful.
Side note: The first time I came across it I was a student and had a job at a restaurant called "Time and Again." The whole staff was reading it and passing it around to one another. I'm a rebel and rejected the notion. A bit later, I read it. It stands as the book I always apologize for loving as much as I do, yet I come as close as I can to making everyone read it. It's one of my favorite fairy tales, told with that terrific historical accuracy and detail.
I didn't care much for his other books, and I thought that the sequel to this was awful - but, oh, give this one a shot. Particularly if you're a New Yorker. It's just so entertaining!
4.0 out of 5 stars Not a master work, but an enjoyable read,
Michael Beverly "Michael S. Beverly" (Orange County, California) - See all my reviews
This review is from: Time and Again (Paperback)
I first came across the name of this book and the author in the book collecting work by Ellis "Book Finds". I enjoy science fiction and time travel stories so I assumed that if a book is worth collecting, it must be worth reading. I wasn't disappointed.
I thoroughly enjoyed the accounts of the time period, as seen by the hero of the book, and the intrigue he gets caught up in (and how it ties to his modern day girlfriend) and they pushed me through the book as a good story should, yet I was getting a bit of a history lesson at the same time.
I will say that as far as science fiction stories go, this isn't the greatest as the science part of the story is a bit weak and if taken away we'd still be left with a period mystery. But knowing the story is being told by the modern onlooker makes it a better story and the situations that he finds himself in because of the time shifts increase the tension.
Anyone enjoying this book because of the time period and setting (end of the nineteenth century New York) might also find the mystery/detective period novels by Caleb Carr to be good reads as well. I also found those, by coincidence, from the same source.
I give a good recommendation for "Time and Again' to any enjoying a good period mystery with the added benefit of time travel thrown in the mix.
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Time and Again by Jack Finney (Paperback - Feb. 1 1995)
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IFI Members in the News
Philanthropy for Hackers
June 29, 2015
Cancer Immunotherapy research led by Carl June, MD, a professor of Pathology and Laboratory Medicine and director of Translational Research in the Abramson Cancer Center, is detailed in a Wall Street Journal column by Sean Parker, co-founder of Napster and founding president of Facebook, in which he calls for his fellow young Internet leaders to use their talents and wealth to transform the world of philanthropy.
Hyperlipidemia May Hike Risk of Allograft Rejection
June 19, 2015
In an editorial published in the American Journal of Transplantation in response to two new studies, Deirdre Sawinski, MD and Jonathan Maltzman, MD, PhD, both Assistant Professors of Medicine in the Renal, Electrolyte and Hypertension Division, emphasize that environmental factors can alter the response to organ transplantation. "These studies show that a high fat-diet impacts the immune response and skews it toward rejection and this suggests that avoidance of a high-fat diet in our transplant recipients may have benefits in terms of decreased rejection episodes in addition to known cardiovascular benefit," Maltzman told Reuters Health.
Survey Reveals Americans Have Potentially Dangerous Misconceptions About Heart Failure
June 17, 2015
Nearly six million Americans currently live with heart failure, yet a recent national survey found that nearly half of those surveyed got fundamental facts about heart failure wrong, according to Medical Express. The article includes a video of Mariell Jessup, MD, an associate chief of clinical affairs in the Division of Cardiology and medical director of the Penn Medicine Heart and Vascular Center, educating people about heart failure.
Penn Researchers Receive $2.9 Million in Awards from the Burroughs Wellcome Fund to Launch Biomedical Research Careers
June 17, 2015
Two Penn researchers, Igor Brodsky, PhD, an assistant professor of Pathobiology and Rahul M. Kohli, MD, PhD, an assistant professor of Medicine, will each receive the Investigators in the Pathogenesis of Infectious Disease award. This award provides $500,000 over five years to support accomplished investigators at the assistant professor level to study pathogeneises, with a focus on the interplay between human and microbial biology.
Best Results
June 16, 2015
A study by Medicine's Ran Reshef and David Porter shows that screening for high T cell counts may optimize the donor selection process for stem cell transplant patients.
HDL Efflux Measure Predicts CHD Events
June 15, 2015
Greater HDL cholesterol efflux capacity is linked to a lower incidence of coronary heart disease events. "We were very interested to find that HDL cholesterol efflux capacity measured in healthy persons predicted risk of a future cardiovascular event even after adjusting for the HDL-C level," Daniel J. Rader, MD, who directs the Preventive Cardiovascular Medicine and Lipid Clinic Medicine and chairs the Department of Genetics, told Reuters Health. He is also the lead author of the Lancet Dibetes and Endocrinology study.
Primary Player
June 10, 2015
A paper by the Perelman School of Medicin'e John Wherry and lab members examine how T cell exhaustion has possible implications for cancer and antiviral therapies.
Penn Researchers Home in on What's Wearing Out T Cells
June 3, 2015
Sometimes even cells get tired. When the T cells of your immune system are forced to deal over time with cancer or a chronic infection such as HIV or hepatitis C, they can develop "T cell exhaustion," becoming less effective and losing their ability to attack and destroy the invaders of the body. While the PD-1 protein pathway has long been implicated as a primary player in T cell exhaustion, a major question has been whether PD-1 actually directly causes exhaustion. A new paper from the lab of John Wherry, PhD, a professor of Microbiology and Director of the Institute for Immunology, in the Perelman School of Medicine at the University of Pennsylvania, seems to -- at least partially -- let PD-1 off the hook. The paper was published this week in the Journal of Experimental Medicine.
Some Chimpanzees Infected with AIDS Virus May Harbor Protective, Humanlike Hene
May 29, 2015
Beatrice Hahn, MD, a professor of Medicine and Micriobilogy, commented in an article in Science magazine about work suggesting a gene in some wild chimpanzees infected with the AIDS virus closesly resembled one that protects humans from HIV. "I'm excited about their finding an allele closely related to B57, albeit in preliminary experiments," Hagn says. "It could be protective, and it could be quickly checked by looking at all the other chimp populations that harbor SIVcpz."
Note of Caution
May 29, 2015
Panel tests can identify cancer linked mutations. Med's Susan Domcheck and Katherine Nathanson say more research is needed to counsel patients.
"Good" Cholesterol Function More Important Than Amount
May 29, 2015
For decades, doctors have fussed over patients' HDL, or "good" cholesterol, levels, prescribing medications to boost them if they drop below the rcommended benchmark. Now, a Lancet study from Penn suggests that focus has been misplaced. Instead of sheer amount, what matters more is how well HDL works to remove fats from blood vessels. "HDL is modestly useful as a predictor of rish, but we're moving toward a time when we think measurement of HDL function might, in fact, be a better way, " senior author Daniel Rader, MD, director, Preventative Cardiovascular Medicine and the Chair of the Department of Genetics, told WHYY.
Penn Study Links Better "Good Cholesterol" Function With Lower Risk of Later Heart Disease
May 27, 2015
HDL is the "good cholesterol" that helps remove fat from artery walls, reversing the process that leads to heart disease. Yet recent drug trials and genetic studies suggest that simply pushing HDL levels higher doesn't necessarily reduce the risk of heart disease. Now, a team led by senior author Daniel J. Rader, MD, director of the Preventive Cardiovascular Medicine and Lipid Clinic at Penn Medicine, has shown in a large, forward-looking epidemiological study that a person's HDL function—the efficiency of HDL molecules at removing cholesterol—may be a better measure of coronary heart disease risk and a better target for heart-protecting drugs. The new study was reported in The Lancet Diabetes & Endocrinology.
Sen. Toomey Talks Penn's Cancer Gene Therapy Accomplishments
May 26, 2015
U.S. Senator Pat Toomey delivered a speech on the floor of the U.S. Senate to highlight the recent innovations in cancer reserach and the importance of federal funding for these efforts, including gene therapy research led by Carl H. June, MD, the Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine and director of Translational Research in Penn's Abramson Cancer Center.
Miraculous Activist
May 19, 2015
James Hoxie, MD, director of the Penn Cener for AIDS Research, was quoted in a Scientist article on Timothy Brown, the "Berlin Patient" who was "functionally" cured of HIV. Diagnosed with acute myeloid leukemia, he received a stem cell transplant from a donor who had the CCR5 mutation in both parents and has remained off drugs since 2008. "Nobody would dare to use the word 'cure' before this happened," Hoxie said. But Brown's cure "has generated an entirely new field of science that we boldly call cure or eradication research."
Global Prize
May 4, 2015
David Weiner and members of his laboratory in the Perelman School of Meidcine received Best Academic Research Team honors at the World Vaccine Congress in Washington.
BBB Maintenance
April 28, 2015
Vet's Jorge Iván Alvarez co-led a study on a protein that helps maintain the blood-brain barrier, lessening the effects of a multiple sclerosis-like disease in an animal model.
Honor for Excellence
April 28, 2015
Carl June, Abramson Cancer Center gene therapy reseracher, ahd received an American Association for Cancer Research award for his innovative work in immunology.
Cancer Drug Shines Against Skin, Lung Cancer
April 20, 2015
The immunotherapy drug known as PD-1 bested the stadard of care in advanced melanoma, researchers reported at the 2015 AACR Annual Meeting. Patients on pembrolizumab (PD-1) had better overall survival and progression free survival rates compared to patients on ipilimumab. "Again and again, new immune therapies are producing meaningful outcomes for our patients, "Robert Vonderheide, MD, DPhil, a professor of Medicine in the division of Hematology/Oncology at the Abramson Cancer Center told Forbes. " The breakthrough drug approved four years ago is now seemingly surpassed, with less toxicity."
Immunotherapy Takes Center Stage at Annual Cancer Meeting in Philly
April 27, 2015
Cancer researchers and oncologists gathered in Philadelphia last week for the 2015 AACR Annual Meeting, where a lot of focus was on immunotherapy, reports WHYY. The piece featured an abstract from Robert Vonderheide, MD, PhilD, a professor in the division of Hematology/Oncology at the Abramson Cancer Center and David Bajoy, MD, and instructor of Hematology/Oncology, on a new combination of immune drugs for melanoma patients. Out of 24 participants, two patients went into complete remission and four others improved. "These types of extroardinary responses achieved by immuntherapy are actually becoming ordinary," said Vonderheid. "Patients are walking away from their cancer forever."
HIV Breakthrough
April 27, 2015
Pablo Tebas, Carl June and Bruce Levine from Medicine's Center for AIDS Research received a presigious award for their personalized gene therapy work in HIV.
April 24, 2015
A study by David Bajor and Robert Vonderheide of the Abramson Cancer Center found a combination of treatments is sage and elicitys a clinical response in melanoma patients.
Cancer Nonprofit Aims to Raise More Money, Profile
April 17, 2015
The American Association for Cancer Research annual meeting, expected to draw over 18,000 cancer researchers and physicians from around the world, begins this weekend in Philadelphia, reports the Philadelphia Inquirer. "It's a stunning meeting," said Robert H. Vonderheide, MD, DPhil, professor of Medicine in the division of Hematology/Oncology in the Abramson Cancer Center. "It instigates collaborations. It helps fund our work. It provides a voice for the work we do."
Changing Lives Through Donating Kidneys to Strangers
April 15, 2015
In continuing coverage, a segment from Nightline features Penn patients Michele and Matt Crane, and their kidney transplant surgeons, Peter Abt, MD, associate professor of Surgery, and Ali Naji, MD, PHD, surgical director of the Kidney and Pancreas Transplant Program. Last month, Matt and Michele participated in what is now the longest multi-hospital kidney transplant chain in U.S. history. Over the course of three months, 68 lives were changed when 34 kidneys were swapped between 26 different hospitals across the nation. "It is a huge operation, but it's driven by the hears and minds of people who want to do it. If there was no love in this, it wouldn't happen," said Naji.
Hereditary Breast and Ovarian Cancers: Moving Toward More Precise Prevention
April 14, 2015
In continuing coverage, a post from Dr. Francis Collins to his NIH Director's Blog reports on the recent Penn-led study published in JAMA which found that among women with mutations in BRCA1/2 genes, the answer to whether a particular individual will develop breast cancer, ovarian cancer, both types of cancer, or neither cancer appears to vary considerably depending upon the precise type of mutation inherited and the locations of these mutations in the DNA sequences of the genes. The post states that the new work by Timothy Rebbeck, PhD, associate professor of Population Science in the Abramson Cancer Center, Katherine L. Nathanson, MD, associate professor of Medicine and director of Genetics in the Basser Center for BRCA, and collegues represents a significant step toward more precise and individualized risk calculations.
"First Step'
April 14, 2015
A sudy led by Timothy Rebbeck and Katherine Nathanson of Medicine found that the risk of breast and ovarian cancer differs depending on a BRCA1 or BRCA2 mutation.
10 Questions: Mariell Jessup, MD
April 13, 2015
In a Medpage Today "10 Questions" article, Mariell Jessup, MD, associate chief of clinical affairs in the division of Cardiology and medical director of the Penn Medicine Heart and Vascular Center, shares her thoughts on a variety of topics - from treatment barriers to advice to other physicians.
Comparing Immunotherapy to Other Cancer Weapons
April 9, 2015
A Philadelphia In uirer story examines progress in various types of immunotherapiesfor the treatment of cancer. "We have tried to learn from the early days of gene therapy and avoid the hype," said Carl June, MD, a profesor of Pathology and Laboratory Medicine and director of Translational Research in Abramson Cancer Center. "What I say in general is, it's the early days, so we don't know everything. We need to have decades of observations. But so far, the toxicity [of immunotherapy] has been less" than conventional oncology weapons.
Penn Medicine, Abramson Cancer Center Team Continues Progress in Investigational Gene Therapy for Blood Cancers
April 8, 2015
The University of Pennsylvania research team behind pioneering studies of an investigational personalized cellular therapy for blood cancers has announced that the United States Patent and Trademark Office has issued several new patents on technologies related to this therapy, known as CTL019. "We are proud to have successifully treated patients with advanced leukemia and lymphoma and to continue refining this therapy and developing new CARs to treat other types of cancers." said Carl June, MD, the Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine in Penn's Perelman School of Medicine, and director of Translational Reserach in the Abramson Cancer Center.
Breast vs. Ovarian Cancer Risks Vary for Women with Different Gene Mutations, Penn Study Finds
April 8, 2015
In continuing coverage, WHYY radio reported on a new study from Penn researchers which shows that the type and location of BRCA mutation helps determine whether women are more likely to develop breast or ovarian cancer. "It doesn't mean you won't get breast cancer or you won't get ovarian cancer," said senior author Katherine L. Nathanson, MD, associate professor of Medicine and director of Genetics in the Basser Center for BRCA and chirf oncogenomics physician in the Abramson Cancer Center. "There's just some relative differences depending on where the mutation is." Lead author Timothy Rebbect, PhD, associate professor of Population Sciences in the Abramson Cancer Center, was quoted in outlets across the antion, influding Reuters Health, HealthDay, and NBC News.
Treatment Results
April 7, 2015
HIV-positive kidney-transplant patients had better outcomes when compared to patients with hepatits C, accourding to a study by Deirdre Sawinski of Medicine.
Gene Therapy
April 1, 2015
Valder Arruda and Julie Crudele of CHOP and the Perelman School of Medicine have produced a mutant protein with high blood-clotting power to treat hemophilia in dogs.
Ken Burns Cancer Documentary of PBS to Focus on Penn Immunotherapy Advance
March 30, 2015
A three-part PBS film "Cancer: The Emperor of All Maladies," presented by Ken Burns, will feature the story of the first pediatric patient to receive Penn's modified T cell therapy for leukemia. Carl June, MD, a professor in the department of Pathology and Laboratoy Medicine and director of Translational Research in Penn's Abramson Cancer Center, and Stephan Grupp, MD, PhD, a professor of Pediatrics and director of Translational Research in the Center for Childhood Cancer Research at the Children's Hospital of Philadelphia, are featured in the film, along with Emily Whitehead and her parents, Tom and Kari Whitehead. Multiple news outlets covered Penn's role in the fil, which ends with an examination of promising Immunotherapies. The film, which is based on the Pullitzer Prize-winning book, "The Emperor of All Maladies: A Biography of Cancer." will air on PBS affiliates across the United States from 9-11 pm for three consecutive evenings, beginning tonight. Emily Whitehead's story appears in the film's final night, April 1.
Gene Counselors Expect Resurgence of 'Jolie Effect'
March 27, 2015
In continuing coverage of Angelia Jolie Pits's decision to publicly discuss preventive measures taken to reduce the risk of cancers associated with BRCA mutations, Narure reports on the state of genetic testing. Thousands of possible mutations in BRCA1 and BRCA2 genes elevate a woman's risk of deloping cancer, but it is impossible to say whether many of these mutaions predispose someone to cancer, because researchers have not seen them enough to know their effects with statistical certainty. "As more and more people are tested, and you identify more and more people with a certain variant, it can go from being a variant of unknown significance to a benighn variant, it can gr from being a variant of unknown significance to a benign variant," syas Katherine Nathanson, MD associate professor of Medicine and director of Genetics at the Basser Research Center for BRCA in the Abramson Cancer Center.
Penn Imunology Program Ranks High in the US News List
March 24, 2015
The Immunology Graduate Group is #6 again this year in the U.S. News & World Report rankings of Best Graduate Schools. According to U.S. News, Penn is one of "the best science schools for immunology/infectious disease." See the U.S. News & World Report website for a list of programs.
Right Now at Penn: Finding a Cure for Cancer
March 24, 2015
Researchers like Carl June of the Perelman School of Medicine are investigating a potential cancer cure by using manipulated virus cells to achieve remision.
Honor Recipient
March 23, 2015
Carl June of Medicine, an expert on cancer and HIV, has been awarded the 2015 Paul Ehrilich and Ludwig Darmstaedter Prize for his work in immunotherapy.
Experimental Therapy Trains Immune Cells to Hunt and Kill Blood Cancers
March 18, 2015
A PBS NewsHour segment traces the story of Penn Medicine's work developing and testing an experimental personalized cellular therapy for cancer, highlighting both promising results in clinical trials for patients with blood cancers and the potential of the therapy in a newly launched trial for patients with brain cancer. Members of the research team including Carl June, MD, David Porter, MD Marcela Maus, MD, PhD, and Donald O'Rourke, MD are quoted in the story, along with a leukemia patient who is in remission after receiving the therapy last year.
Giving Hope
March 17, 2015
A study led by Medicine's Andy Minn suggests that radiation along with two immunotherapies may be more effective in helping shrink metastatic melanoma tumors.
Primate Lineage
March 2, 2015
Two of the four groups of human AIDS viruses originated in western lowland African gorillas, according to research by Beatrice Hahn of the Perelman School of Medicine.
Radiation Plus Immunotherapy Combo Revs up Immune System to Better Attack Metastatic Melanoma, Penn Study Suggests
March 10, 2015
Treating metastatic melanoma with a tripple threat - including readiation therapy and two immunotherapies that target the CTLA4 and PD-1 pathways - could elicit an optimal response in more patients, ont that will boost the immune system's attack on the disease, suggests a new study from a multidisciplinary team of reearchers from Penn's Abramson Cancer Center published today in Nature. The study was led by authors Andy J. Minn, MD, PhD, assistant professor of Radiation Onclolgy, Robert Vonderheide, MD, DPhil, the Hanna Wise Professor in Cancer Research, Amit Maity, MD, PhD, professor of Radiation and Oncology, E. John Wherry, PhD, professor of Microbiology and director of the Insitute for Immunology at the Perelman School of Medicine at the University of Pennsylvania, and Lynn M. Schuchter, MD chief of Hematology/Oncology at Penn's Abramson Cancer Center.
Two Strains of HIV Cut Vastly Different Paths
March 5, 2015
In continuing coverage, a study showing that two of the four known groups of human AIDS viruses (HIV-1 groups O and P) originated in western lowland gorillas, appeared in several outlets. The international research team conducted a comprehensive survey of simian immunodeficiency viral infection in African gorillas. Coauthor Beatrice Hahn, MD, a professor of Medicine and Microbiology, was quoted.
Two Strains of HIV Cut Vastly Different Paths
March 3, 2015
Two of the four known groups of human AIDS viruses (HIV-1 groups O and P) have originated in western lowland gorillas, according to an international team of scientists. They conducted a comprehensive survey of simian immunodeficiency viral infection in African gorillas, published this week in the Proceedings of the National Academy of Science. Coauthor Beatrice Hahn, MD, a professor of Medicine and Microbiology, was quoted in several outlets, including the New York Times and the Los Angeles Times.
Killing Cancer
March 2, 2015
A VICE special report on efforts to treat cancer using the power of viruses and other immunotherapeutic approaches profiled Carl June, MD , a professor of Pathology and Laboratory Medicine and director of the Translational Research in the Abramson Cancer Center, and Stephan Grupp, MD, PhD, a professor of Pediatrics and director of Translational Research in the Center for Childhood Cancer Research at the Children's Hospital of Philadelphia. Two pediatric patients who participated in the clinical trials of the Penn-developed cellular therapy known as CRL019 were also featured in the show.
Biomarker Levels Associated with IRIS in Patients with HIV, TB
February 20, 2015
Reporting in the Lancet Infectious Diseases, Shruthi Ravimohan, PhD, a research associate in the division of Infectious Diseases, and Gregory P. Bisson, MD, MSCE, an assistant professor in the division of Infectious Diseases and a senior scholar at the Center for Clinical Epidemiology and Biostatistics, evaluated over 200 patients in Botswana before and after they began antiretroviral therapy, and found several immune biomarkers that may help better stratify patients, and guide future research and treatments before HIV treatment begins.
NIH researchers reveal link between powerful gene regulatory elements and autoimmune diseases
February 17, 2015
Investigators with the National Institutes of Health have discovered the genomic switches of a blood cell key to regulating the human immune system. The findings, published in Nature today, open the door to new research and development in drugs and personalized medicine to help those with autoimmune disorders such as inflammatory bowel disease or rheumatoid arthritis. The lead author, Golnaz Vahedi, Ph.D., will be joining the Perelman School of Medicine in May 2015 as an Assistant Professor in the Department of Genetics.
Cancer Gene Therapy Moves Ahead
February 16, 2015
A Fox News segment details progress in Penn's gene therapy trials for blood cancers, including the story of a patient who was one of the first participants in studies to test this new approach, who remains cancer-free more than four years later. One of the trial's leaders, David Porter, MD, a professor of Hematology-Oncology and director of Blood and Marrow Transplantation in the Abramson Cancer Center, is quoted in the story, and in a San Diego Union Tribune article recapping the results of the trials so far.
The Future of Precision Medicine
February 16, 2015
David Roth, MD, PhD, director of the Center for Personalized Diagnostics and chair of the department of Pathology and Laboratory Medicine, explained to the audience of SiriusXM's "POTUS" radio show that precision medicine helps diagnose individuals more accurately. Doctors are able to pinpoint a particular kind of illness a patient has and treat it more effectively, instead of a process of trial and error.
Physician Turned Patient Finds Low Fat Good for His Heart
February 16, 2015
A Philadelphia Inquirer article asks: Can a modified vegan diet -- heavy of tofu, whole grains, fruits and vegetables, and low on saturated and trans fats -- significantly help with heart disease? Daniel Rader, MD director of the Preventative Cardiovascular Program, says that avoiding saturated and trans fats is the most important dietary change one can make to reduce the risk of heart disease.
Is Your Heart Older Than You Are?
February 10, 2015
A Prevention magazine article about improving your "heart age" includes advice from Daniel Rader, MD, director of the Preventative Cardiovascular Program. He says that for someone with a family history of heart disease, in addition to leading a healthy lifestyle, taking a statin can further reduce the risk of a heart attack.
New Biomarker
February 9, 2015
A somatic gene mutation is a potential molecular marker for rare adrenal tumors, according to research by Katherine Nathanson and Lauren FIsbein of Medicine.
Inflammation Application: How Tumor-Causing Cells are Recruited in Cancers Linked to Chronic Inflammatory Diseases
February 9, 2015
Investigators including, Dmitry Gabrilovich, MD, PhD have demonstrated what is happening at a cellular level that allows for chronic inflammation to cause a variety of cancers; inflammatory conditions are associated with a specific phenotype of myeloid cells called immature granulocytic cells, they report.
Immune Biomarkers Help Predict Early Death, Complications in HIV Patients with TB, Penn Study Finds
February 9, 2015
Doctors treating patients battling both HIV and tuberculosis (TB) - many of whom live in Africa are faced with the decision when to start those patients on entrepreneurial therapy (ART) while they are being treated with antibiotics for active TB disease. Reporting in a new study published online this week in The Lancet Infectious Diseases, researchers under the Botswana-UPenn Partnership, including Shruthl Ravimohan, PhD, a research associate in the division of Infectious Disease, and Gregory P. Bisson, MD, MSCE an Assistant Professor in the division of Infectious Diseases, have identified immune biomarkers in these patients before they begin ART.
Mosquitoes Ramp Up Immune Defenses After Sucking Blood, Penn Vet Researcher Finds
February 6, 2015
University of Pennsylvania and Imperial College London researchers learned in a new study that after ingesting a meal of blood, mosquitoes ramp up production of immune system proteins that help fight off the parasites that blood might contain. "This appears to be a new mechanism by which the mosquito is anticipating a parasite infection," said Michael Povelones, an assistant professor in Penn's School of Veterinary Medicine, who coauthored the study. A greater understanding of how mosquitoes naturally fight off infection could offer a strategy for preventing humans from getting infected with those same pathogens.
Sugar Switch
January 29, 2015
Slow-healing wounds are a serious problem for diabetics. A study led by Dental Medicine's Dana Graves has identified a molecule that may be responsible.
Penn Study Reveals Possible Therapeutic Target for Common, but Mysterious Brain Blood Vessel Disorder
January 27, 2015
Cardiovascular scientists at the Perelman School of Medicine at the University of Pennsylvania have studied a pathway in heart development to discover an important set of molecular signals, triggered by cerebral cavernous malformation-linked gene defects that potentially could be targeted to treat the disorder. "We hope that these findings will lead to a better understanding of the origins of CCM, and thus to treatment possibilities," says Mark L. Kahn, MD, a professor of Cardiovascular Medicine, and senior author of the new study, published in Developmental Cell.
Honor Recipient
January 26, 2015
For his work in cancer biology, Xianxin Hua of Medicine has been awarded a Harrington Scholar-Innovator Award and $100,000 for two years to support his research.
Important Work
January 23, 2015
Beatrice Hahn of Medicine will be honored by the American College of Physicians for her research on the origins of the human AIDS viruses and malaria parasites.
Joint Infections
January 23, 2015
Based on a review led by Dental Medicine professor Thomas Sollecito, the ADA issued a new guideline regarding the use of antibiotics before dental procedures.
Mutated ATRX Gene Linked to Brain and Pancreatic Neuroendocrine Tumors is Potential Biomarker for Rare Adrenal Tumors Too
January 21, 2015
A somatic mutation in the ATRX gene recently demonstrating potential as a molecular marker for aggressive brain tumors could also serve as a biomarker for rare neuroendocrine tumors, according to a new Penn Medicine study in Nature Communications, reports Endocrine Today. "We have identified, for the first time, somatic ATRX mutations in pheochromocytomas and paragangliomas," said Katherine Nathanson, MD, an associate professor in the division of Translational Medicine and Chief Oncogenomics Physician for the Abramson Cancer Center. The mutation could not only serve as that biomarker for metastatic disease, but also a potential therapeutic drug target in the future
Inovio Begins Human Testing of Cancer Therapy
December 22, 2014
A Philadelphia Business Journal blog post covered a newly-opened phase I clinical trial using hTERT DNA immunotherapy. The drug will be tested in adults with breast, lung, or pancreatic cancer at high risk of relapse after surgery and other cancer treatments. The ultimate goal is to reduce the risk of relapse in these patients. "The next great wave of oncology advancements will be treatments which empower the patient's own immune system to seek and destroy cancer," said principal investigator, Robert Vonderheide, MD, PhD, the Hanna Wise Professor in Cancer Research in the Abramson Cancer Center.
Can AIDS be Cured?
December 17, 2014
A feature in The New Yorker on HIV/AIDS referenced a Penn Medicine study published in New England Journal of Medicine in March on HIV gene therapy and CCR5, a rare mutation that provides a natural resistance to the virus. In that study, Carl H. June, MD, the Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine and director of translational research at the Abramson Cancer Center, and colleagues successfully genetically engineered the immune cells of 12 HIV positive patients to resist infection, and decreased the viral loads of some patients taken off antiretroviral drug therapy entirely.
Recent IFI Faculty Awards and Honors
Jim Riley, Ph.D.
2014 recipient of the Lady Barbara Colyton Prize for Autoimmune Research
Daniel Rader, M.D.2014 recipient of the prestigious Clinical Research Award
Kenneth Shindler, M.D.
Recipient of the American Academy of Ophthalmology AchievementAward


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Feeding Bowl with Crab Design
Your pet will instantly fall in love with the Melia Pet Blue Crab Ceramic Dog Bowl. This stylish bowl is great to feed food and water to your pet. It's made of durable ceramic. This high quality stoneware bowl features a cute blue colored crab picture inside to make feeding time fun. Plus, it's available in small, medium and large sizes for your pet's feeding convenience.
Melia Pet Blue Crab Ceramic Dog Bowl
This pet bowl is great to be taken out too. It allows you to feed your pet almost anywhere, even when you are outdoors with your pet.
A Closer Look: Melia Pet Blue Crab Ceramic Dog Bowl is a durable bowl for your canine that's made of ceramic.
Made Specially for: Dogs of all ages
|1 cup
|5 x 1.5 inch
|3.5 cup
|6.75 x 2.5 inch
|6 cup
|9 x 3 inch
Please choose which cart you want to add the item.
By choosing one of the above, you are able to shop for both yourself and a registrant at the same time. Once you are ready to checkout your items will be waiting for you in both your personal and registry shopping carts.
Still need assistance?
Please contact us at 1-866-SHOP-WAG (1-866-746-7924)


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30 year old woman | Atlanta, GA, USA | Seeking men 25-40 within 50 miles
Fun-loving and looking for someone to make me laugh!
Do I love doing new things? Not exactly. Does online dating scare me a little? Definitely. There are a lot of things I love to do for fun but music - in all its forms - has to be at the top of the list. I love playing music, writing music, listening to music...you get the picture. I play guitar and piano, but my real love is singing. There's nothing I love more than a good drive in my car, singing at the top of my lungs. Maybe one day I'll finally quit my day job and do music all the time, but I'm not there just yet. I moved to Atlanta and changed jobs in the past year, so I'm still learning about all the things there are to do here. I moved so I would be closer to my family, but a side benefit is that for the first time I actually I enjoy what I do. The hours are hard and it seems like I'll never get everything done, but I love the people I work with and all the gadgets I get to play with. Some random facts about me: - I re-read books the way some people watch movies over and over. To me a book is just a movie in my head with better dialog. - My favorite drink is diet coke with fresh lime juice - I'm addicted to the game blitz on my phone. - I named my car Lucy so I could yell at her when the GPS screws up (Lucy, you've got some 'splaining to do!). - I get really annoyed when people write anything with incorrect capitalization or punctuation. It's just lazy, in my opinion. I love to read and laugh and be with friends playing games, drinking coffee, or just sitting around watching tv. I'm looking to meet someone who takes time to really listen, who won't laugh at me because I love Doctor Who (that's a British tv show in case you didn't know), and who will like me for me, quirks and all. So, want to grab a pint of Guinness (or tea) with me?
Alumni connections , Camping , Coffee and conversation , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Performing arts , Playing cards , Playing sports , Watching sports
Aerobics, Baseball, Basketball, Dancing, Football, Soccer, Swimming, Tennis / Racquet sports, VolleyBall, Walking / Hiking
I exercise 1-2 times per week.
Don't display my sign
I like Cats, Dogs, Horses
I would love to have a dog, but I feel it's unfair to have an animal when I live in a small space. My family has always had retrievers, so I love dogs that swim and fetch.
I love going to my family place on Lake Burton, and I also love vacationing in St. Simons Island. I'm new to Atlanta, so I don't have too many favorite spots in the city yet.
Rice University, Houston, TX
My favorite type of music is bluegrass - I both play and write music as well. My favorite bands are Punch Brothers, Bon Iver, Radiohead, Ryan Adams, Sufjan Stevens, and more. I love watching movies and tv - right now I'm loving Covert Affairs.
I love to listen to and play music. I like going to sporting events (Braves games) and watching football (I prefer college to NFL). I grew up in the mountains, so I also like spending time on the lake and in the woods.
Easy and entertaining books.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'5" (165cms)
|5'5" (165cms) to 8'11" (271cms)
|Body type:
|A few extra pounds
|No preference
|No preference
|Dark blonde
|No preference
|No Way
|No Way, Occasionally, Cigar aficionado
|Social Drinker
|Social Drinker
|Technical / Science / Computers / Engineering
|No preference
I am a manager at a start-up software company in Atlanta that designs software for mobile devices (iPhones, iPads, iPods, Android, etc.).
|I'll tell you later
|No preference
|Never Married
|Never Married, Widow / Widower, Divorced
|Have kids:
|No preference
|Wants kids:
|Definitely, Someday
|White / Caucasian
|No preference
|Christian / Protestant
|Christian / Catholic, Christian / Protestant, Spiritual but not religious, Christian / Other
|Chinese, English
|Bachelors degree
|Bachelors degree


text: on Mar 26, 2013 @ 10:31 AMMar 26, 2013 @ 10:31 AM Published Qatar urges $1 bn fund for Palestinians in east JerusalemQatar's emir called on Tuesday for the immediate establishment of a $1 billion fund to help Palestinians in Arab east Jerusalem, and offered to contribute $250 million towards it.Sheikh Hamad bin Khalifa Al-Thani, made the proposal at the opening of an Arab League summit, saying other Arab countries must provide the remainder, and that the fund would be run by the Islamic Bank in Jeddah, Saudi Arabia.He gave no details for its implementation.The Gulf Arab state last year promised $400 million to help rebuild the Islamist Hamas-controlled Gaza Strip, heavily damaged by successive Israeli military operations, the latest in November 2012.The emir also proposed holding a small-scale Arab summit in Egypt aimed at reconciliation between Hamas and its Ramallah-based rival Fatah, which controls the West Bank and is headed by president Mahmud Abbas.Hamas welcomed the initiative, praising "the Egyptian, Arab and Islamic efforts to support and speed up Palestinian national reconciliation and unification," spokesman Sami Abu Zuhri said in a statement.Reconciliation efforts between Fatah and Hamas, which has controlled Gaza since 2007 after ousting Fatah forces, stalled after an agreement in Doha in 2012 between Abbas and Hamas chief Khaled Meshaal.Qatar's simultaneous offer of funds for east Jerusalem came as Abbas's Palestinian Authority was debating a draft budget amounting to $3.9 billion, of which it said $1.4 billion would have to come from foreign financing.Prime minister Salam Fayyad lamented a lack of payment of foreign aid as he presented the 2013 draft budget to politicians and economists in Ramallah, the seat of the Palestinian Authority, on Monday."The principal reason for our financial crisis last year was the lack of payment of foreign financial aid that was counted on," he said.On Friday, following a three-day visit by US President Barack Obama to Jerusalem and Ramallah, a top official in Washington said the US had unblocked almost $500 million in aid to the Palestinian Authority that had been frozen by Congress for months.And Israel is to immediately unblock revenues it collects on behalf of the Palestinian Authority, frozen last year in retaliation for the Palestinians winning upgraded UN status, the Israeli premier's office said Monday.Total 2013 expenditure, including on development, would amount to almost $3.9 billion, the Palestinian Authority draft budget said.The government's recurring deficit would be just over $1.0 billion, and its total deficit stands at $1.4 billion.The draft will be discussed on Tuesday and Wednesday, and will have to be approved by Abbas by Sunday.The Palestinian Authority's gross debt stands at $3.8 billion.The World Health Organisation on Monday said hospitals in east Jerusalem were at risk of failing to treat patients due to the Palestinian Authority's financial woes, calling on international donors to step up aid."The PA's debt to the East Jerusalem Hospitals Network (supported by the WHO and the EU) has persisted as donor support to the PA has decreased," it said."Staff salaries are consistently paid late and basic supplies for quality clinical care are lacking," its statement added.There is "risk (of) closing down entire departments due to the increasing financial deficit," it said, urging donors to "support the PA to meet its obligations."he/jad/al


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Colin Mullikin wrote:1000 Megabytes = 1 Gigabyte.
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Colin Mullikin wrote:tester
GeorgeZiozas wrote:Is there any certificate that i can follow atm which i can pass without any pro knowledge of programming?
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GeorgeZiozas wrote: im officially a FREE man with no school responsibilities!
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CBadger wrote:Anyone able to get the info out of that damn chicken to why it crossed the road?
CBadger wrote:So what happened in the past 2 months that I should be aware of?
CBadger wrote:Anyone able to get the info out of that damn chicken to why it crossed the road
General News Suggestion Question Bug Answer Joke Rant Admin
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Certified Commercial Investment Member Virginia Wright, of Bull Realty, was hired by Edward Zorn, CCIM, of Joshua Realty & Loan to sell the 10,771-square-
Within the first month of being on the market, Wright presented an offer from Neil Efron, CCIM, who serves as director of acquisitions for Noble Properties of Greenacres, Fla. Shortly after negotiations started, Zorn and Efron signed a pooling servicer agreement. The deal closed earlier this month and Noble Properties took over as the owner.
"It's certainly a good situation to have all three sides in a sale represented by CCIMs," said Wright, vice president of the Net Lease Investments for Bull. "Working with two other people who know the in's and out's of this type of sale helped in moving the deal along quickly and smoothly."
CCIMs are recognized experts in the disciplines of commercial and investment real estate. The designation is awarded by the CCIM Institute and more than 9,500 professionals around the world hold the title.
About Bull Realty:
Bull Realty is a regional commercial real estate brokerage firm with three offices headquartered in Atlanta. The firm provides corporate services in the southeast and investment sales throughout the nation. The firm was founded fourteen years ago with two primary missions: to grow a company known for integrity and to provide the best marketing platform in the nation.
Among the firms other institutional and private clients Bull Realty provides marketing and special asset services for seventy-four lenders and servicers around the country. The firm's commercial real estate web portal, www.BullRealty.com has become the go-to source in the southeast for commercial real estate information, resources, properties and services. The firm's broker is the host of America's Commercial Real Estate Show, a national talk radio show focused on commercial real estate topics.


text:
Earlier today on The Whitney Johnson Experience, Roger Mooney of The Tampa Tribune joined the show to talk all things Tampa Bay Rays.
Why you should listen: Roger talked about the Winter Meetings he is currently attending in Orlando. Roger gave us the latest including an update on James Loney.
The Whitney Johnson Experience comes to you live Monday through Friday 3pm – 7pm
Roger Mooney on The Whitney Johnson Experience: December 11, 2013http://audio.sportstalkflorida.com/1040/RM121113.mp3 [1]
Talk with us during the show:
Chat with us online:
Whitney Johnson: Follow @Whitter1040 [3]
Gerardo Gonzalez: Follow @GGonzalezJr [4]


text: We were pleasantly surprised by this hotel. Our room was upgraded as it was our honeymoon, we had a lovely view with dual aspect windows. The bathroom was also very fancy with a deep bath and large shower. We feel it could have been a little cleaner, replacing sealant would help. The duvet is a little on the small side.... More


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Too much by extroverts' standards, that is. I can entertain myself and I enjoy my own company ...
This is totally correct. Describes me perfectly....except I am an adrenaline junkie, but mostly an introvert.
"I've never been a millionaire but I just know I'd be darling at it."- Holly Golightly Best movie ever.
I craft all the time. I give away and sell my crafts. But sometimes I have so much I don't know what to do with it!
The hardest thing for me to understand is why someone would ever say something they don't mean. Being an honest person means you are honest 100% of the time.
You will feel this way for a long time, healing is a long process - take it easy on yourself and move slow.
Sounds like "Do You Believe in Love?" by NewWorldSon. Not the exact words but same idea. "Some wanna change your mind and tell you loves a breeze. Lovely breeze, it's a hounding wind. Could knock a man to his knees!" Love that song.
Can't wait to find the one that wants to be awkward with me or loves me for my awkwardness and is not awkward :-)


text:
20 years later, Oklahoma City-based Lopez Foods is feeding the world
Lopez Foods already exports to Japan and Korea, and Lopez said the company wants to continue its international growth. It also is focusing on environmental initiatives, including becoming "zero landfill" by 2020.
Diversity is the key ingredient to the company's success and creates a family atmosphere among workers, Lopez said.
"That's what being diverse is all about: embracing the differences that make everybody so unique and special. That, to me, is what makes our workforce so great," he said.


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The widespread and increasingly intensive use of glyphosate in association with the use of GM (genetically modified) crops poses further risks to the environment and human health.
In 2004, farming and environmental groups in Canada combined their forces to make Monsanto withdraw its request to commercialise genetically modified (GM) wheat.
The reason? No-one wanted to buy it.
Going once… Going twice... SOLD to the chemical company who wants to control our food supply!
Greenpeace activists stopped a genetically modified (GM) wheat experiment outside Canberra on the 14th July 2011. The following FAQs explain why Greenpeace removed the controversial GM wheat crop.
Ninety percent of genetically engineered (GE) seed is made and owned by one US company called Monsanto, and they don't want us to know when GE is in our food.
Australia is on the brink of a complete shift in the way that we produce and consume food. Our most important staple crop and major agricultural export – wheat – is under serious threat.
Monday 27 June, 2011, Canberra: Prestigious scientists from around the world are questioning the safety and scientific rigour of world-first human feeding trials being conducted this year by the CSIRO on genetically modified (GM) wheat.
Friday 15 July 2011, Sydney: Greenpeace is once again calling on CSIRO to publicly reveal the corporate relationships behind the GM wheat trials.
Celebrity chefs Ben Shewry from award-winning restaurant Attica and Andrew McConnell from Cutler and Co today are calling for the clear labelling of genetically modified (GM) food. They signed on to a 30,000-strong petition that Andrew is...
Thursday 21 July 2001: At just before 12 noon today, the Australian Federal Police raided and locked down Greenpeace's Sydney headquarters. The raid came after activists last week removed a genetically modified wheat experiment from a site near...
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The Greenpeace Google Search will also return results form http://archive.greenpeace.org - Greenpeace's archive of web content dating back to 1994, along with content from those few Greenpeace websites not shared on this.
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(3) Comments | Posted 29 June 2015 | (11:50)
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These Glastonbury pictures show the sheer scale of the largest greenfield festival in the world.
The festival gets underway today with over 175,000 revelers crammed into the 900-acre Worthy Farm in Somerset.
But these incredible aerial photographs make them look like ants and with another 40,000 security guards,...
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David Beckham has taken his son and Guy Ritchie fishing in Weymouth (according to locals), which led to what can only be described as 'Beatlemania' style meltdown on Twitter.
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Sydneysiders were treated to an incredibly rare natural phenomenon early on Wednesday evening when a double rainbow appeared over the city.
This sent residents and travelers alike, from the capital of New South Wales and one of Australia's largest cities, into an instant photographic frenzy, prompting thousands of people to...
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The Fiji Pro Surfing heats were held in Tavarua, Fiji this weekend with Owen Wright and Italo Ferreira progressing through to the quarterfinals.
Wright who made history with a perfect heat said after the event, "I'm absolutely blown away by how good it is out there, I...
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With the Premier League 2015/16 season still a few months away, teams are already releasing their new kits in time for summer.
Football fans around the world wait with bated breath to see their teams new strip for the season ahead, so we've got them all in one...
(0) Comments | Posted 11 June 2015 | (09:33)
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(0) Comments | Posted 8 June 2015 | (15:03)
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(3) Comments | Posted 8 June 2015 | (10:57)
The Daily Overview Instagram is simply stunning. If you're afraid of heights then this might not be the story for you, but we urge you to carry on reading.
This incredible project is breathtakingly beautiful and derives its name from a term used by astronauts known as the...
(20) Comments | Posted 5 June 2015 | (14:23)
As the world marks 71 years since the launch of the D-Day mission which ultimately led to victory over Nazi Germany during World War Two, these before and after pictures show the true horror and heroism on a day that changed the world.
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(0) Comments | Posted 15 May 2015 | (10:30)
Prince Harry is the world's favourite royal, if these pictures are anything to go by.
The 30-year-old Prince has spent just over a week traveling around Australia and New Zealand where he was met with a rapturous reception.
Harry, who was twice deployed to Afghanistan, is now fifth in line...
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These aerial photographs show how Nepalese villagers are surviving in makeshift tents and relying on food drops after a huge earthquake hit Kathmandu.
The devastating quake left over 7000 people dead and many more trapped under the debris as emergency rescue workers attempt to clear rubble....
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Out-of-favour Tottenham striker Emmanuel Adebayor has taken to Facebook to help other 'African families to learn' from his family experiences.
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Property is in demand due to reduced inventory, as there are more potential buyers than sellers. Bidding wars with other buyers are possible, and listings begin to sell at greater than the asking price.
Not enough data to determine market type. Consult a local REALTOR® for up-to-date market summaries
Trend data coming soon.
Trend data coming soon.
|For Sale: 12
|New: 1
|Recently Sold: 1
|Reduced: 4
|Average Home Price
|Average Sold Price
|Property Records: 688
|Foreclosed: N/A
The average home price in 35765 is $104,019, which is 7.9% lower than the average sold price in 35765 ($113,000) . The average home price per square foot in 35765 is $50 and about 0% of all homes in 35765 sold in the last 6 months. For 35765 home values, real estate prices, and city market trends, research the 688 property records or search our 1 recently sold or 12 homes for sale listings. The listings and properties in 35765 are only a part of the 1,551,592 properties and 36,353 homes for sale in Alabama. Because of this, the average home price and average home value of 35765 also influence the average home price $150,679 and average sale price $202,260 of Alabama. Listing counts, 35765 home prices and home values in 35765 are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.
|Median Age
|Median Household Income


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