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Publications (21)95.27 Total impact
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ABSTRACT: Cohesin is present in almost all active enhancer regions, where it is associated with transcription factors. Cohesin frequently colocalizes with CTCF (CCCTC-binding factor), affecting genomic stability, expression and epigenetic homeostasis. Cohesin subunits are mutated in cancer, but CTCF/cohesin-binding sites (CBSs) in DNA have not been examined for mutations. Here we report frequent mutations at CBSs in cancers displaying a mutational signature where mutations in A•T base pairs predominate. Integration of whole-genome sequencing data from 213 colorectal cancer (CRC) samples and chromatin immunoprecipitation sequencing (ChIP-exo) data identified frequent point mutations at CBSs. In contrast, CRCs showing an ultramutator phenotype caused by defects in the exonuclease domain of DNA polymerase ɛ (POLE) displayed significantly fewer mutations at and adjacent to CBSs. Analysis of public data showed that multiple cancer types accumulate CBS mutations. CBSs are a major mutational hotspot in the noncoding cancer genome.Nature Genetics 06/2015; DOI:10.1038/ng.3335 · 29.65 Impact Factor
Article: Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry[Show abstract] [Hide abstract]
ABSTRACT: Pseudomyxoma peritonei (PMP) is a relatively rare clinical syndrome characterized by neoplastic epithelial cells growing in the peritoneal cavity and secreting mucinous ascites. Our aim was to explore the molecular events behind this fatal but under-investigated disease. We extracted DNA from 19 appendix-derived PMP tumors and nine corresponding normal tissues, and analyzed the mutational hotspot areas of 48 cancer-related genes by amplicon-based next-generation sequencing (NGS). Further, we analyzed the protein expression of V600E mutated BRAF, MLH1, MSH2, MSH6, and p53 from a larger set of PMP tumors (n = 74) using immunohistochemistry. With NGS, we detected activating somatic KRAS mutations in all of the tumors studied. GNAS was mutated in 63% of the tumors with no marked difference between low-grade and high-grade tumors. Only one (5.3%) tumor showed oncogenic PIK3CA mutation, one showed oncogenic AKT1 mutation, three (15.8%) showed SMAD4 mutations, and none showed an APC mutation. P53 protein was aberrantly expressed in higher proportion of high-grade tumors as compared to low-grade ones (31.3% vs. 7.1%, respectively; p = 0.012) and aberrant expression was an independent factor for reduced overall survival (p = 0.002). BRAF V600E mutation was only found in one (1.4%) high-grade tumor by immunohistochemistry (n = 74). All the studied tumors expressed mismatch repair proteins MLH1, MSH2, and MSH6. Our results indicate that KRAS mutations are evident in all and GNAS mutations in most of the PMPs, but BRAF V600E, PIK3CA, and APC mutations are rare. Aberrantly expressed p53 is associated with high-grade histology and reduced survival. © 2014 Wiley Periodicals, Inc.International Journal of Cancer 10/2014; DOI:10.1002/ijc.29245 · 5.01 Impact Factor
Article: Comparison of serial debulking and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei of appendiceal origin[Show abstract] [Hide abstract]
ABSTRACT: Patients with pseudomyxoma peritonei (PMP) benefit from cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Reports on this modality usually have included only patients with successful HIPEC treatment, which can potentially cause biased results. We report the survival of a PMP population treated by CRS and HIPEC, including patients who were not eligible for HIPEC. The outcome of the whole population of 87 patients with PMP treated by CRS and HIPEC in Helsinki University Central Hospital between 2008 and 2011 was evaluated. The results of treatment were compared with 33 patients treated by serial debulking in our unit between 1984 and 2008. Of the 87 patients in the HIPEC-era group, 56 received HIPEC, 12 were treated non-radically in an attempt at HIPEC, 9 were debulked and 10 were referred back or transferred to palliative care without surgery. The 5-year overall survival for the debulking-era group and the HIPEC-era group were 67 and 69 %, respectively. The number of patients with no evidence of disease was higher in the HIPEC-era group (47/87) than that in the debulking-era group (8/33) at the end of the follow-up. Overall survival for patients who underwent successful CRS and HIPEC at 2 and 5 years was 95 and 93 %, respectively. The improved survival from using the CRS and HIPEC was not apparent after 5-year follow-up, when the whole patient population was included in the analysis. Even so, patients successfully treated by CRS and HIPEC manage well.International Journal of Colorectal Disease 06/2014; 29(8). DOI:10.1007/s00384-014-1933-8 · 2.42 Impact Factor
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ABSTRACT: Gastric outlet obstruction (GOO) commonly occurs in advanced gastric cancer. Our aim was to evaluate the results of endoscopic stenting (ES), palliative resection (PR), and gastrojejunostomy (GJ) as palliation of GOO. A total of 97 patients (50 ES, 26 PR, 21 GJ) were included in this retrospective study. All the patients had primary gastric cancer and symptoms of GOO. Compared to surgery, ES resulted in a faster improvement on oral intake and symptom relief (P < 0.001) and a shorter hospitalization (P < 0.001). Complication rates, hospital re-admissions, occurrence of biliary obstruction, and the number of patients receiving chemotherapy were similar. The median symptom-free and overall survival were longest in the PR group (P < 0.001). In multivariate survival analysis, independent prognostic factors were age, BMI, pre-procedure GOOSS, palliative resection as treatment modality, and chemotherapy. In gastric cancer and GOO, the clinical condition of the patient before treatment affects survival and should be taken into account in determining the treatment. PR seems to provide a survival benefit and should be considered as treatment option for patients suitable for surgery. For patients unfit for surgery, ES provides rapid and efficient palliation. Chemotherapy also seems to improve survival in gastric cancer and GOO. J. Surg. Oncol. 2013; 108:537-541. © 2013 Wiley Periodicals, Inc.Journal of Surgical Oncology 12/2013; 108(8):537-41. DOI:10.1002/jso.23442 · 2.84 Impact Factor
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ABSTRACT: Intestinal obstruction is a common complication in peritoneal cancers. Obstructions occur especially as the cancer advances, at a time when life expectancy is often only a few months. Characteristic symptoms include nausea, vomiting, constipation, lack of bowel function, colicky and persistent abdominal pains. Conservative treatment aims to secure intestinal transit by applying pharmacologic therapies in cases where surgical therapy in partial or functional obstruction is not possible or reasonable. Pharmacologic therapy consists of antisecretory and antiemetic drugs combined with opioids.Duodecim; lääketieteellinen aikakauskirja 01/2013; 129(4):410-7.
Article: Stenting for malignant colorectal obstruction: a single-center experience with 101 patients[Show abstract] [Hide abstract]
ABSTRACT: Self-expanding metal stents (SEMS) are used for colorectal obstruction preoperatively and palliatively. Limited data on the use of stents for obstruction caused by extracolonic malignancies exist, and the results are unclear. Our goal was to evaluate the efficacy and safety of SEMS for patients stented as a bridge to surgery and as palliation for colorectal cancer or extracolonic malignancies. Between 1998 and 2009, a total of 101 patients underwent 108 stenting procedures for malignant colorectal obstruction. The results were studied retrospectively. Of the study cohort, 11 patients were stented as a bridge to surgery. For palliatively stented patients, the etiology of obstruction was colorectal cancer in 66 patients and extracolonic malignancy in 24. Overall technical success was 99% and clinical success 88%. Complications occurred for 20 (20%) patients in 22 of 108 procedures. Complications included perforation (n = 6), recurrent obstruction (n = 8), and stent migration (n = 4). A median time to complication was 81.5 days. The overall stent placement-related mortality was 2/101 (2%). For patients stented as a bridge to surgery, a primary anastomosis in elective operations was achieved for 90% (9/10). In the palliation groups, patients with colorectal cancer had significantly higher clinical success rates than patients with extracolonic malignancies (94% vs. 65%, P = 0.0005). There was no difference in complications, operation, and stoma rates between the palliation groups. SEMS is a safe and effective treatment for patients stented as a bridge to surgery or as palliation due to colorectal cancer. Stents are also useful in relieving obstruction due to extracolonic malignancies, but the clinical failure rate is higher than for colorectal cancer.Surgical Endoscopy 09/2011; 26(2):423-30. DOI:10.1007/s00464-011-1890-z · 3.31 Impact Factor
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ABSTRACT: Self-expanding metal stents (SEMS) have been successfully used as a "bridge to surgery" or as palliation for acute malignant colorectal obstruction. Little data on the use of stents for benign obstruction exists and the results vary. The purpose of this study was to evaluate the efficacy and safety of SEMS in benign colorectal obstruction. A total of 21 patients with 23 SEMS procedures between the years 1998 and 2008 were retrospectively studied. Eight patients had an obstruction in the surgical anastomosis. In addition, there were two patients with anastomotic strictures due to Crohn's disease. In 10 patients the obstruction was caused by diverticular disease and one patient had a stricture after radiation therapy. Technical success was achieved for all the patients. Clinical success was achieved for 76% (16/21) of the patients. The anastomotic strictures were resolved with SEMS in 5 out of 8 cases (63%). Three patients with diverticular stricture (30%) were eventually resolved with SEMS. Nine (43%) patients in 10 out of 23 procedures (43%) had a complication, the majority being in patients with diverticular stricture. SEMS is a good treatment option for patients with anastomotic stricture of the colon and for patients with benign colonic stricture who are unfit for surgery. SEMS can be used as a bridge to surgery in diverticular obstruction but there seems to be a considerable risk of complications. If a SEMS is placed into a diverticular stricture, the planned bowel resection should be performed within a month.Scandinavian Journal of Gastroenterology 03/2010; 45(6):725-31. DOI:10.3109/00365521003663696 · 2.33 Impact Factor
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ABSTRACT: In pseudomyxoma peritonei a mucinous tumor of the appendix spreads into the abdominal cavity. Cytologic picture of the tumor may be benign, malignant or intermediary. The symptoms were previously relieved by repeated resections of the tumor mass, whereby even the most benign form of the disease progressed slowly. A method has now emerged in which radical-aimed surgery is combined with intraperitoneal lavage with a warmed solution of a cytotoxic agent. This treatment is associated with a morbidity of 33 to 56% and a mortality of 0 to 18%. Controlled studies have not been carried out on the novel treatment.Duodecim; lääketieteellinen aikakauskirja 01/2010; 126(14):1693-9.
Article: Outcome for self-expandable metal stents in malignant gastroduodenal obstruction: single-center experience with 104 patients[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Malignant gastric outlet obstruction (GOO) leads to malnutrition and limits quality of life. Gastrojejunostomy has been the traditional treatment for GOO. Recently, the results of releasing duodenal obstruction with self-expandable metal stents (SEMS) have been encouraging. METHODS: After the exclusion of 13 patients with gastrojejunal or jejunal strictures and 1 patient with intraabdominal lymphoma, the authors palliated the malignant GOO in 104 patients with 130 SEMS at a single center during the years 1999-2007. RESULTS: The GOO was caused by pancreatic (n = 51), gastric (n = 24), duodenal (n = 7), biliary (n = 5), and other (n = 17) malignancies. Of the 104 patients, 76 (73%) did well with only one enteral stent placement, 21 (20.2%) required two stent placements, 4 (3.8%) required three stent placements, and 1 required four stent placements. The median dysphagia score was 0 before stenting and 2 after treatment (p < 0.001). Immediate failure occurred after 10 procedures (7.7%). Among the 104 patients, 6 (5.8%) died of stent placement-related reasons. Complications occurred for 13 patients (12.5%). The median hospital stay was 3 days, and the overall survival time was 62 days (range, 1-933 days). Of 11 patients with concomitant biliary obstruction and GOO, 10 (91%) underwent successful enteral and biliary stent placement within the same session. Of 15 patients experiencing jaundice after enteral stent placement, 6 (40%) underwent endoscopic biliary drainage successfully. CONCLUSION: Enteral stenting is a safe and effective way to treat GOO. Gastrojejunostomy should be preserved for cases in which endoscopic stenting is not successful or possible.Surgical Endoscopy 09/2009; 24(4). DOI:10.1007/s00464-009-0686-x · 3.31 Impact Factor
Article: Primary sclerosing cholangitis: outcome of patients undergoing restorative proctocolecetomy for ulcerative colitis[Show abstract] [Hide abstract]
ABSTRACT: The prevalence of primary sclerosing cholangitis (PSC) among patients with ulcerative colitis needing proctocolectomy is about 12%. The study aim was to evaluate the progression of the liver disease after surgery. PSC progression in 68 patients with UC after restorative proctocolectomy was evaluated after a median follow-up of 11 years (range 0 to 21). Magnetic resonance imaging (MRI) of the liver, histological examination of a core needle liver specimen, and liver function tests were used in addition to clinical history. Of the 68 patients, 30 participated in follow-up examinations. Ductal changes in MRI suggesting a diagnosis of PSC occurred in 21 (72%) of them. One carcinoma of the gallbladder was found in MRI. Histopathologic changes suggesting PSC were observable in 15 (50%) patients. Compared to stage in peroperative biopsies taken at proctocolectomy, PSC stage increased in four (13%) patients, decreased in 15 (50%), and remained unchanged in 11 (37%). Immunohistochemical staining for cytoceratin-7 in hepatocytes was positive in nine (30%) indicating cholestasis. After IPAA surgery, five patients underwent liver transplantation at 1, 1, 5, 6, and 11 years, respectively. Of the 68, six patients have, to date, developed cholangiocarcinoma. Progression of PSC in patients with minor ductal changes at the time of restorative proctocolectomy is unlikely. Those patients with more advanced disease at surgery are at risk for disease progression and liver transplantation. We lack accurate diagnostic methods to detect premalignant changes of the biliary epithelium.International Journal of Colorectal Disease 08/2009; 24(10):1169-74. DOI:10.1007/s00384-009-0773-4 · 2.42 Impact Factor
Article: [Colonic carcinoma].[Show abstract] [Hide abstract]
ABSTRACT: Colonic carcinoma is the third most common cancer in Finland. Cardinal symptoms include a change in bowel function and rectal hemorrhage. The first line treatment of this cancer, both localized and metastatic, is surgery. Before surgery, the patient is subjected to colonoscopy and computed tomography scanning of the body, and the concentration of carcinoembryonic antigen in serum is determined. The surgical operation aspires to a local radicality by excising the part of colon bearing the tumor along with the corresponding mesocolon. If metastases are detected in the mesenteric lymph nodes or elsewhere, use of chemotherapy is considered postoperatively.Duodecim; lääketieteellinen aikakauskirja 02/2009; 125(6):619-28.
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ABSTRACT: Since benign and malignant mucin-producing tumors of the pancreas may be difficult to distinguish from each other; preoperative methods for differential diagnosis would reduce unnecessary surgery. To compare syndecan-1 and tenascin immunoexpression in benign and malignant cystic pancreatic tumors. We used immunohistochemical staining for syndecan-1 and tenascin antibodies in tumor tissue samples. Helsinki University Central Hospital. Tissue material came from 33 patients undergoing surgery from 1979 to 2005 for cystic pancreatic tumors. A statistically significant difference appeared in syndecan-1 expression between benign (mucinous cystic neoplasms and intraductal papillary mucinous neoplasms) and mucinous carcinomas, but there was no significant difference in tenascin immunoexpression between these tumor groups. Our findings suggest that low syndecan-1 expression might serve as a predictive factor for malignancy in cystic tumors of the pancreas.JOP: Journal of the pancreas 02/2009; 10(4):378-82.
Article: [Rectal cancer].[Show abstract] [Hide abstract]
ABSTRACT: The most common symptom of rectal cancer is bleeding. The average diagnostic delay is half a year. Colonoscopy, magnetic resonance imaging of the pelvis and computed tomography scanning of the body are carried out before the operation to assess the extent, and the level of carcinoembryonic antigen is determined from the serum. In cancers grown through the intestinal wall or spread to the mesorectal lymph nodes, local radiotherapy is applied preoperationally. The surgical operation involves total mesorectal excision with low-rectal anastomosis. Cytotoxic chemotherapy of a disseminated cancer will improve the quality of life.Duodecim; lääketieteellinen aikakauskirja 02/2009; 125(8):857-65.
Article: Prevalence of primary sclerosing cholangitis in ulcerative colitis patients undergoing proctocolectomy and ileal pouch‐anal anastomosis[Show abstract] [Hide abstract]
ABSTRACT: Background: This study aimed to determine the prevalence of primary sclerosing cholangitis (PSC) among patients with ulcerative colitis (UC) needing proctocolectomy.Methods: The study sample included 441 consecutive patients who underwent proctocolectomy with ileal pouch-anal anastomosis from 1993 to 2004 at the Helsinki University Central Hospital. Liver biopsy samples were taken at operation. Patient groups with and without PSC were compared.Results: PSC was present in 52 (11.8%) patients. Only 19 of these had been diagnosed before surgery; 40 patients with PSC were detected by liver biopsy at the operation, making the sensitivity of perioperative liver biopsy to diagnose PSC 83.3%. The cumulative incidence of colorectal dysplasia or cancer in the UC patients with PSC (19% after 10 years and 43% after 20 years) was not significantly different than that of UC patients without PSC (24% after 10 years and 39% after 20 years). Pouchitis occurred more often in patients with PSC (25 of 52; 48.1% versus 101 of 389, 26.0%; P = 0.001). The failure rate of ileal pouch–anal anastomosis did not significantly differ between the 2 groups.Conclusions: The prevalence of PSC among patients with UC needing proctocolectomy was higher than in patients with UC in general. Liver biopsy can be recommended as a safe adjunct at proctocolectomy for surveillance of any liver effects.(Inflamm Bowel Dis 2008)Inflammatory Bowel Diseases 01/2008; 14(6):775 - 779. DOI:10.1002/ibd.20384 · 5.48 Impact Factor
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ABSTRACT: Grade III and IV anal sphincter ruptures after vaginal delivery are an increasing problem. We assessed the outcome of an overlap technique in primary repair. In this retrospective observational study, from 2002 to 2004, 61 consecutive women with grade III and IV obstetric tears were included. Of the 61 women, 42 had complete rupture of the external sphincter and underwent sphincter repair using standardised overlap technique. The outcome was assessed by clinical examination, Wexner questionnaire, and endoanal ultrasonography (EAUS), after a median follow-up of 9.4 months. Main outcome measure was continence following primary repair. At follow-up, 64% of the patients had no symptoms of anal incontinence. A total of 29% experienced occasional incontinence to flatus, 1 patient (2%) experienced occasional incontinence to liquid stools, and 1 patient to liquid or normal stools. EAUS revealed intact external sphincter in 29 of the 35 patients (83%). In 6 patients (17%), EAUS showed partial discontinuity of the sphincter muscle. The results show that the primary overlap technique in the repair of anal sphincter rupture following vaginal delivery is highly successful.Acta Obstetricia Et Gynecologica Scandinavica 02/2007; 86(12):1458-62. DOI:10.1080/00016340701709372 · 1.99 Impact Factor
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ABSTRACT: The potential association of CD2AP with the adherens junction protein E-cadherin, co-localization with the actin cytoskeleton, and involvement in cell migration was investigated in cultured rat gastric mucosal cells. In stationary cells, CD2AP was localized perinuclearly while E-cadherin was expressed along cell-cell contacts and F-actin formed a branched network and adhesion belts. In migrating cells, CD2AP appeared as thread-like accumulations in the leading edges, colocalizing with F-actin and occasionally with E-cadherin. Intracellular injection of anti-CD2AP significantly retarded the migration speed of the cells suggesting a crucial role for CD2AP in mucosal cell migration, possibly as a scaffolding protein between cell membrane proteins and actin cytoskeleton. Co-immunoprecipitation assays revealed that CD2AP and E-cadherin are in a complex in HGF stimulated cells. It is concluded that CD2AP interacts with E-cadherin and co-localizes with F-actin in the leading edge of migrating cells, and significantly contributes to cell migration in restituting gastric epithelium.Biochemical and Biophysical Research Communications 08/2005; 332(2):426-32. DOI:10.1016/j.bbrc.2005.04.140 · 2.28 Impact Factor
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ABSTRACT: Peutz-Jeghers syndrome (PJS) is typically manifested as severe gastrointestinal polyposis. Polyps in PJS patients and in Lkb1(+/-) mice that model PJS polyposis are frequently characterized by elevated cyclooxygenase-2 (COX-2). This study was designed to determine whether COX-2 inhibition would reduce tumor burden in Lkb1(+/-) mice or Peutz-Jeghers patients. Genetic interactions between Cox-2 and Lkb1 in polyp formation were analyzed in mice with combined deficiencies in these genes. Pharmacologic inhibition of COX-2 was achieved by supplementing the diet of Lkb1(+/-) mice with 1500 ppm celecoxib between 3.5-10 and 6.5-10 months. In PJS patients, COX-2 was inhibited with a daily dose of 2 x 200 mg celecoxib for 6 months. Total polyp burden in Lkb1(+/-) mice was significantly reduced in a Cox-2(+/-) (53%) and in a Cox-2(-/-) (54%) background. Celecoxib treatment initiating before polyposis (3.5-10 months) led to a dramatic reduction in tumor burden (86%) and was associated with decreased vascularity of the polyps. Late treatment (6.5-10 months) also led to a significant reduction in large polyps. In a pilot clinical study, a subset of PJS patients (2/6) responded favorably to celecoxib with reduced gastric polyposis. These data establish a role for COX-2 in promoting Peutz-Jeghers polyposis and suggest that COX-2 chemoprevention may prove beneficial in the treatment of PJS.Gastroenterology 11/2004; 127(4):1030-7. DOI:10.1053/j.gastro.2004.07.059 · 13.93 Impact Factor
- Duodecim; lääketieteellinen aikakauskirja 02/2004; 120(19):2353-4.
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ABSTRACT: The purpose of this study was to determine the cumulative success rate of Kock continent ileostomy and the reasons leading to excision and to compare the results with pelvic pouch and ileal pouch-anal anastomosis. The data were collected from the histories of 96 patients, who underwent a Kock continent ileostomy operation from 1972 to 2000 at Helsinki University Central Hospital. The failure rate was calculated by the Kaplan-Meier method. Overall, the continent ileostomy was converted to conventional stoma in 21 patients (24 percent). The cumulative success rate was 96 percent at 1 year, 86 percent at 10 years, 77 percent at 15 years, and 71 percent at 29 years. The most common reason for pouch excision was partial or total nipple-valve sliding. Eighty-five re-reconstructions were performed among 57 patients (59 percent), the most common indication being nipple-valve dysfunction. Of these patients, 14 later ended up with pouch excision. The success rate of continent ileostomy was significantly lower than that of ileoanal anastomosis (P < 0.01). The durability of continent ileostomy is mainly related to the mechanism of the nipple valve and not to ileitis or other systemic effects of the basic disease. Kock continent ileostomy can offer satisfactory long-term function in more than two-thirds of patients up to 30 years.Diseases of the Colon & Rectum 07/2003; 46(7):925-8. DOI:10.1097/01.DCR.0000075207.34462.05 · 3.20 Impact Factor
Article: CD2-associated protein (CD2AP) interacts with E-cadherin in a cell culture model simulating gastric restitutionGastroenterology 04/2003; 124(4). DOI:10.1016/S0016-5085(03)82258-8 · 13.93 Impact Factor
Top Journals
Hospital District for Helsinki and UusimaaHelsinki, Uusimaa, Finland
University of Helsinki
Helsinki, Uusimaa, Finland
- IV Department of Surgery
Helsinki University Central Hospital
Helsinki, Southern Finland Province, Finland
- • Department of Surgery
- • Division of Gastroenterology


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East Central puts end to King's playoff hopes
Every time King High had the football, it drove into opposing territory.
The problems arose soon after crossing midfield.
The Mustangs saw their postseason hopes get shattered Friday night at Cabaniss Stadium. Though King took all nine possessions into San Antonio East Central's side of the field, the Mustangs scored only twice.
That led to a 21-14 defeat for King in the District 27-5A contest. Coupled with Carroll's victory over Victoria Memorial, the Mustangs were eliminated from postseason contention.
"We shot ourselves in the foot a lot," King coach Jim Elam said. "Terribly, terribly inconsistent on offense. We just kept making mistakes."
King (3-6, 3-3) had four possessions end on failed fourth down conversions, one on a punt and another two on interceptions. One of the interceptions - a pick by defensive lineman Samuel Posos on a screen pass at the end of the third quarter - was a real backbreaker.
Posos returned the ball 56 yards to the Mustangs 9. On the next play, Marcus Jeter raced in for a touchdown to make the score 21-6 Hornets.
"If we don't give them one, throwing a middle screen pick, they don't score in the second half," Elam said.
That offset a big game by receiver Ram Guerrero, who consistently made big plays. Guerrero finished with 120 receiving yards, 34 rushing yards and 16 via the pass. He accounted for little more than half of the Mustangs' total yards.
But that wasn't enough.
"We just made so many mistakes on offense," Guerrero said. "We started doing good, but couldn't turn it on at the end. That led to our downfall."
East Central (5-5, 4-2), which already had clinched a playoff spot, controlled the first half, leading 14-0. The Hornets had 12 first downs and 147 rushing yards - including 102 from Gary Coleman. An end-around pass for a touchdown loomed large.
Meanwhile, King had three possessions with three failed fourth-down conversions, getting stopped on the East Central 29, 25 and 18.
The Mustangs rebounded in the second half, as the defense surrendered only 56 total yards. And the offense got in gear, driving seven plays and reaching the end zone on a Phillip Thomas 19-yard run. A missed extra point made the score 14-6.
King rallied with a frantic drive on its last possession - with Guerrero running and passing on the drive - to cut the lead to 21-14 with little more than a minute remaining.
But the Hornets recovered an onside kick by the Mustangs. East Central was able to run out the clock, depriving King of one more shot at getting into Hornets' territory.
RUSHING - EC, Gary Coleman 21-115, Desmond Scallion 8-58, Thomas Blount 4-19, Jeter 5-9, Ortega 7-(-8), Team 1-(-2). KING, Thomas 17-79, Ram Guerrero 2-34, Morales 5-24, Nate Perez 4-14, Stephen Morrison 1-1.
PASSING - EC, Ortega 4-9-0-23, Rogers 1-1-0-41. KING, Morales 7-17-2-128, Morisson 1-1-0-43, Guerrero 1-1-0-16.
RECEIVING - EC, Benavides 1-41, Travis Viator 1-8, Blount 1-6, Devon Duncan 1-5, Rogers 1-4. KING, Guerrero 5-120, Chris Jackson 2-35, Thomas 1-16, Morales 1-16.
Contact Lee Goddard at 886-3613 or goddardl@ caller.com
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subset: commoncrawl


text:
Financial StudiesThe Financial Studies department has many different degree and certificate offerings. Please select a program below.
This program provides basic accounting knowledge to students planning to enter the profession at a junior level in business and/or government.
Associate of Applied Science
Associate of Applied Science
- Accounting Certificate
- Business Accounting Certificate
- New! CPA Exam Qualification Certificate — This program is designed to qualify a student holding a Bachelor's degree, as approved by the Maryland State Board of Public Accountancy, to sit for the CPA examination.
Associate of Arts


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Narrow your search
The Apple Watch is the most ambitious, well-constructed smartwatch ever seen, but first-gen shortfalls make it feel more like a fashionable toy than a necessary tool.
Smartwatches. Health monitors. Pedometers. Activity trackers. They're all part of the emerging landscape of wearable technology, which promises to change the way we exercise and communicate. We've collected the best products in this upstart category below.
The Vector smartwatch has an attractive metal design and loads of smart skills, but it's the promised 30-day battery life that makes it really stand out.
Regular watch, overlaid with a see-through glowing smart screen: the Kairos Watch is crazy indeed.
Pricing not available
Huawei's first smartwatch has a stainless steel body, mesh strap, circular display and heart-rate sensor.
Pricing not available
The LG Watch Urbane is the best-looking Android Wear smartwatch and adds Wi-Fi-to-phone connectivity, but it doesn't offer all that much more than previous Android Wear watch models.
Thanks to plenty of apps and an affordable price, the original plastic Pebble remains a solid budget smartwatch pick.
The Alcatel OneTouch Watch is an affordable and reasonably attractive basic smartwatch, but it doesn't work well enough to justify choosing one over better and increasingly comparably priced alternatives.
The subscription based security company gets in on the Apple hype with new controls customized for the Apple Watch.
Pricing not available
LG has a proprietary superwatch on the way with mobile payments, phone calls and more. We tried it out.
Pricing not available
At just 8mm thick and packing a directional mic and speaker, the Hot Watch links to iPhones and Android devices to view alerts and take calls hands-free.


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Top Definition
A really cool girl, that is freinds with a guy named Yis, and is cool to the max.
My name in Francesca Sloane and I'm so cool.
by Yisrawayl Goodwin January 28, 2005
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text:
Feature Requests item #2765730, was opened at 2009-04-15 17:25
Message generated for change (Tracker Item Submitted) made by zdv038
You can respond by visiting:
Please note that this message will contain a full copy of the comment thread,
including the initial issue submission, for this request,
not just the latest update.
Category: Other
Group: None
Status: Open
Priority: 5
Private: No
Submitted By: Mathilde (zdv038)
Assigned to: Nobody/Anonymous (nobody)
Summary: CIS should keep CIP registration information
Initial Comment:
CIS should maintain a configuration file or some other persistent mechanism to keep the list of CIPs to contact even if CIS stops working properly. It is annoying to have to reconfigure the lists of CIPs again and again.
You can respond by visiting:


text:
This paper begins with an examination of BYOPC and its shortcomings. It closes with a look toward the future – Consumerization – and how cloud and web services are combining to finally deliver on the advantage of the new realities of BYOD.
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Results 1 to 13 of 17
Thread: Obama Call for Artists
October 7th, 2011 #1
Obama Call for Artists
Just a heads up if anyone is interested in this. Ad popped on FB this afternoon. I won't be adding my 2 cents I have so much to do elsewhere, but I think I'd do a contemporary realism piece depicting an opium field with happy workers in the sun....
"Obama for America is seeking poster submissions from artists across the country illustrating why we support President Obama's plan to create jobs now, and why we'll re-elect him to continue fighting for jobs for the next four years.
Your poster can address the broader themes of the President's plan or pinpoint a specific aspect, from supporting small businesses to rebuilding roads and bridges for the 21st century. For more on the desired specs..."
Last edited by Izi; October 7th, 2011 at 05:02 PM.
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October 7th, 2011 #2
Oh wow, that's a pretty big deal - thanks man (lady)!
October 7th, 2011 #3
...I'll support him once he gets rid of ObamaCare...
My Sketchbook:
October 7th, 2011 #4
That says a few things. They're trying to recapture Fairy's iconic poster. Their expensive marketing team can't come up with anything. So what they'll do is put the call out to a bunch of people who will gladly give up their hard work for a smile and a hand-shake.
I know, I know. "But it'll be famous! Part of history! etc" Plenty of commissioned pieces are a part of history. But buying artwork isn't hip. It just doesn't have the right feel.
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October 7th, 2011 #5
So, let me get this straight...
The Obama Administration wants a poster (which will presumably be seen by millions everywhere) to advertise President Obama's plan to create jobs as a part of his campaign for re-election but they don't wish to compensate (as in monetary payment) said artist for his/her hard work and effort (i.e. doing his/her job)? Now, can that be considered an "irony?"
Please, correct me if I'm wrong. I just didn't see anything about compensation for this other than an autographed print.
"Contrary to the belief of the layman, the essential of art is not to imitate nature, but under the guise of imitation to stir up excitement with pure plastic elements: measurements, directions, ornaments, lights, values, colors, substances, divided and organized according to the injunctions of natural laws. While so occupied, the artist never ceases to be subservient to nature, but instead of imitating the incidents in a paltry way, he imitates the laws."-Andre Lhote
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October 8th, 2011 #6
Well, a poster signed by the first black president would be worth ALOT even on the street right away. 20 years from now it would probably be priceless.
But I agree that it is tacky all around, still great publicity. Any artist would have it made with that kind of showing. (seen by millions is nothing to sneeze at)
October 8th, 2011 #7Visit Chiseled Rocks - my art site · Visit my Conceptart.org sketchbook
October 9th, 2011 #8
Obama's signature is already going for $1300 on the low end so i guess the answer to that question is based on the artist's IQ, and publicity also has monetary value.
Even though I don't agree with many of Obama's choices, anything that pisses off the Nazis trying to take over our government, like supporting a black man in office, is fine with me. I don't buy into the idea that spec work hurts everybody. Competitions have been some of the most fun and engaging events in my life.
Last edited by Izi; October 9th, 2011 at 03:53 PM.
October 10th, 2011 #9Registered User
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What he isn't going those re-use the 1930's Hitler propaganda style posters again?(hey go compare get freaking history book made before 1980) We as Artist should be part of anything these Political BS in DC is pushing. None of them care about Us just for their jobs and the Money and power they steal from us.
October 10th, 2011 #10
I'll be the dumb European and ask: What's the big deal with ObamaCare?
Bonus question: How much tax is deducted from salaries in US? (In the countries I've worked it depends on your situation, but the norm is around 20% give or take)
October 10th, 2011 #11
Our tax system is a mess. I've been looking up numbers for another thread. How much tax is taken depends on what bracket you belong to. Plus different types of income are taxed differently. So earning a wage or salary means you're taxed differently than someone who lives off financial investments or selling property. Just looking at income, the most someone will be taxed is around. And once that's settled, there's a wacky formula used to calculate the final number.
A single person who earns $379,151 or more will have 35% of their salary eligible for taxation. That doesn't mean they will actually be taxed that much. It's just a starting point for that tax bracket. The real amount paid will depend on what I said above and what deductions the person can claim. The median income in the us for 2010 was between $49,000 and $50,000. The median income is often lower than the average, I can't find the average income level. But a person making that much would have 25% of their income be eligible for taxation.
I would consider $50,000 to range from comfortable to slightly-struggling, depending on what state you live in. Each state has different average incomes and different average living expenses. $50k is comfortable where I live but in NYC it may be hard to make ends meet with that. If I earned $379,151 a year, I would consider myself wealthy, even though I wouldn't be a millionaire or billionaire.
"Astronomy offers an aesthetic indulgence not duplicated in any other field. This is not an academic or hypothetical attraction and should require no apologies, for the beauty to be found in the skies has been universally appreciated for unrecorded centuries."
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October 10th, 2011 #13
The problem with political organizations is that it shows a disconnect with the people they're ironically trying to connect to. I think the message than an artist should get paid because they need jobs too is a very worthy cause as well. Obama and any politician often get money from their cause for lobbyists to support the cause. They're not an organization that need help in the sense, other organizations like the feeding the homeless, helping the disabled need.
Obama was originally a grass roots effort, his re-election is not.
Also oh fuck didn't see someone Darwin'd the thread :/
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My god... where to begin... everything is just too much work, everything, anything and everything you think of is too much work, reading this right now is too much work, writing this is just..... too much work.
*thinks* well saying anything is just way too much work and well... even thinking is just too much work... lets kill ourselves.
by Chris Ogburn March 15, 2007


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Most news sources are funded by corporations and investors. Their goal is to drive people to advertisers while pushing the corporate agenda. NationofChange is a 501(c)3 organization funded almost 100% from its readers–you! Our only accountability is to the public. Click here to make a generous donation.
People who spearhead things like this are fond of speaking in generalities and then making "innocent" suggestions that there is a causal link between X and Y when, in fact, there is none. Their over active imaginations become diabolical from being immersed in lifetime worldview of fear.
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Prosthesis making results in a superior product when a hollow plastic form is filled with a resilient wadding and a discrete weight. The attributes of external appearance and feel on one hand and the feel associated with wearing the prosthesis on the other hand are dealt with separately. No attempt is made to provide homogeneity or uniform density. Skin is represented by a plastic outer shell or form, inner flesh by wadded fibers compressed to provide feel, and weight is represented by one or more discrete, flexible weights placed to facilitate holding the prosthesis in position. Flesh color is simulated by including cosmetic powder of selected color in the translucent plastic shell. The process and the product of the process are described and a breast restoration is described in particular.
Claims available in
Description (OCR text may contain errors)
[1 1 3,811,133 [451 May 21, 1974 United States Patent n91 Harris WEIGHTED PROSTHETIC BREAST page 45, Surgery, Gynecology & Obstetrics, October 1964, Vol. 119, No. 4.
Primary Examiner-Richard A. Gaudet 1 Assistant Examiner-Ronald L. Frinks [22] Filed:
, 0r Firm-Grover A. Frater Attorney, Agent ABSTRACT Prosthesis making results in a superior product when a 264/222 A6lf1/00, A4lc 3/10 hollow plastic form is filled with a resilient wadding [58] Field Of 3/36; and a discrete weight The attributes of external ap- 463 pearance and feel on one hand and the feel associated with wearing the prosthesis on the other hand are e n wa 5 n u 9, n m W m m. mS sw m TM 10 WA... U .l e "A n." C.. 0"m e mme .m. cT r mAmnK D. vac h ll le .HSLMMH M a wnww m9999m HHH n 9 7W m a 2 Q MVA DJO 2 1C 1 as. 3 man 233 Fd Camp Tru Life Breast Prosthesis, advertisement 5 Claims, 6 Drawing Figures 1 WEIGHTED PROSTHETIC BREAST This invention relates to cosmetic prostheses or restorations. Prosthetic restorations are worn by persons, portions of whose bodies are missing. Some restorations, and portions of others, are worn primarily for cosmetic purposes and their value is enhanced if they look and feel natural rather than artificial.
No material has been found which has the color, the resilience, the feel, and the density of human skin and flesh. A number of plastic materials are now available that can be made to have a resilience that approximates the resilience of skin. However, some of those materials have an unpleasant feel and some are difficult to color properly or present other problems. Only a very limited number of materials survive even approximate screening for suitability.
It has been discovered that soft vinyl plastic can be made to have the proper resilience and feel to represent skin. However, it is not satisfactory for representing flesh and attempts to make prosthetic restoration of solid pieces of vinyl plastic have not produced an adequate realism in the finished product. Some attempts have been made to make prostheses in the form of air or liquid-filled, properly shaped balloons. Making the ballons of vinyl has improved them but they have been difficult to keep from leaking and both the air-filled and liquid-filled variety lack realism. They feel and behave like what they are air balloons and water bags.
The difficulty is solved in the invention by creating a relatively thin walled form of soft plastic material, advantageously vinyl, and stuffing the cavity of that form with a resilient fibrous material such, for example, as a wad of synthetic fibrous material. Nylon, Orlon and Dacron" are names of suitable materials. The quantity of fibrous material is varied so that the requisite under-surface, or under-skin, resiliency is achieved. Neither the plastic form nor the wad of fibers has a density approximating that of skin and flesh but that difficulty is overcome in the invention by adding a weight inside the form. The weight is placed at a point where it aids in keeping the restoration in place and making it feel natural, but where it does not have an adverse effect on the resilience. The invention takes advantage of the fact that the density of a prosthetic restoration does not affect its appearance. Weight is of importance only to the wearer of the restoration. The weight should closely approximate the weight of the body part being restored and the weight should be distributed enough to feel right. But density need not be uniform and the use of specific weights in an otherwise light-weight restoration makes it easier to keep the restoration in place.
The difficulty in achieving realism is increased as the volume, and in particular, as the bulk of the restoration is increased. Making a breast restoration is particularly difficult because of its size. The problem is simplified somewhat because it is normally held in place with a bra and is not exposed to view. Nonetheless, natural appearance and feel is demanded by the wearers of artificial breasts and contributes greatly to an improved attitude in the patient about her plight. The invention, while applicable to production of cosmetic prosthetic restorations in general, is particularly well suited to the making of breasts. Its object is to produce better, more realistic, prosthetic restorations and in particular to produce better and more realistic breasts.
Another object is to provide a method for making restorations in a color that matches the color of the wearer, that are realistic in other respects as well, that will last indefinitely, and that are relatively inexpensive to manufacture. By their very nature, most cosmetic prosthetic restorations are custom made. They must fit a particular individual, have an outward appearance consistent with the wearers size and shape, and they must be colored to match the wearers color. If it meets those requirements, a restoration can contribute greatly to the appearance, the feeling, and the mental attitude of the wearer and an object of the invention is to make those benefits more easily available to more people.
In the drawings:
FIG. 1 is a pictorial view of a prosthesis embodying the invention;
FIG. 2 is a cross-sectional view taken on line 2-2 of FIG. 1;
FIG. 3 is a cross-sectional view taken on line 3-3 of FIG. 2;
FIG. 4 is a view in rear elevation of the prosthesis of FIG. 1;
FIG. 5 is a crosssectional view of a fragment of the rear wall of the prosthesis taken on line 5-5 of FIG. 4; and
FIG. 6 is a view in elevation of an alternative form of weight, a portion of its cover having been removed to show its interior.
The prosthesis shown in FIG. 1 is'a representation of a breast and parts of those muscles that are removed from a patient in a radical mastectomy. The prosthesis itself is designated by the reference numeral 10. The breast portion 12 includes a representation of a nipple 14 and a surrounding areola 16. The rear surface 18 is best shown in FIG. 4. It is shaped as the complement of the scar surface over which the prosthesis is to be applied. The other side 20 is called the forward or outer side. The rear and forward surface walls are joined or are integrally cast to create a hollow breast form. The walls are made of a soft resilient material having the approximate resilience of human skin. In a preferred embodiment of the invention that form is made of a soft vinyl plastic sufficiently pliant so that it would collapse under its own weight if unfilled. It is filled, however, with a wadding 22 of fibrous material. The material is wadded so that it is resilient. It is not essential that the entire filling or stuffing comprise a single wad prior to being disposed within the form. Smaller wads can be inserted and together they form the equivalent of a single wad in the finished product.
Enough wadding is inserted so that its resilience gives the product a realistic feel. The walls 18 and 20 need not be of the same thickness or even the same resiliency or even of the same material. However, it is found that best results are achieved when they are made of the same material and of approximately the same thickness. That provides the functional advantage that the outer wall 20 looks and behaves like skin when viewed from the outside and that the rear wall 18 feels and behaves like skin to the wearer. The thickness is variable with the hardness of the material but is advantageously between one-sixteenth and one-quarter of an inch thick. Advantageously, the forward wall is between one-sixteenth and three-sixteenths of an inch thick.
The thickness will be increased somewhat at the margins where the rear wall and forward wall are joined as illustrated in FIGS. 2 and 3. The dimensions given are appropriate for the intermediate parts of the wall.
It is important from the wearers standpoint that the breast be weighted to similate a natural breast. In the invention a weight is disposed within the form in proximity to the rear wall 18. It is not necessary that the weight be fastened to the rear wall or even to touch it. It is enough if it is imbedded in the wadding 22 so that it is relatively close to the rear wall and is separated from the forward wall by a substantial amount of the wadding. In the embodiment shown in FIGS. 1 through of the drawing, the weight 24 is bonded to the rear wall 18.. It is located centrally on the rear wall at a position opposite the fullest or nipple portion of the breast.
Both the form and the wadding are lightweight. Ac-
cordingly, the weight must be quite heavy. Its actual value depends upon the volume of the prosthesis and will vary from less than a pound to several pounds so its density must be substantial. It is a feature of the invention that the weight is made flexible. In preferred form, bits of metal are imbedded in a very flexible casing. Bits of metal such as lead shot housed in a bag of plastic felt or imbedded in a body of soft, pliant plastic has been found to be particularly well suited to the task. The weight 24 is formed by stirring lead pellets in melted vinyl plastic so that all of the pellets are coated with the plastic. An additional quantity of melted plastic is added and the plastic-coated pellets are stirred into that. The mixture is allowed to harden to form a heavy but very flexible weight. Some of the pellets are visible in FIGS. 2 and 3 where a few of them are designated by the reference numeral 28 for identification. Making the weight of vinyl plastic is convenient because it is necessary only to apply sufficient heat to melt their surfaces to permit bonding of the weight and the rear wall 18. 1
Examination of FIGS. 2 and 3 will show that the weight 24 is placed so that the center of gravity of the finished prosthesis lies substantially on that horizontal line where it would lie in a natural breast. However, the center of gravity is located more rearwardly than would be true in a natural breast. For the wearer, the feeling is made much more natural if the weight is placed at the rear adjacent the wearers chest wall. Some cosmetic prostheses are attached to the body with adhesives. When the weight is placed against the rear wall as it is shown to be in FIG. 2, the use of adhesives is ordinarily unnecessary and the weight of the breast can ordinarily be supported adequately by the users bra.
To improve adhesion of the prosthesis to the body without actual sticking, the rear surface of the prosthesis is made somewhat irregular. This is done conveniently by corrugating the rearmost surface as shown in FIG. 4 and in the cross-sectional view of FIG. 5.
An alternate weight construction is shown in FIG. 6. Here, lead or steel shot 40 is placed between two layers 42 and 44 of felt, such for example as a Dacron felt. The felt layers are sewn together around their margins and along a number of parallel seams so that the shot is distributed rather uniformly in long parallel pockets. The result is a very high density and very flexible weight which may simply be inserted in the form in close proximity to its rear wall.
To achieve proper coloring, the forward wall 20 is made of a transparent material, or nearly transparent material, which is coated with, or has imbedded within it, cosmetic powder of a shade that matches the wearers skin color. Realism is enhanced if the material itself is slightly colored with mother-of-pearl. It is not essential that the rear wall 18 be colored but it is preferred.
To make prostheses of this and other kinds one makes an impression, in the negative, of the area over which the prosthesis is to be applied. That mold or impression may be made with plaster-of-paris bandage placed over the surgery area. In the case of a mastectomy, a mold is made of the entire chest including the remaining breast if any. A positive mold is then made of the surgery area of that impression. That mold is advantageously made of a mixture of hydrocal and water from which air has been removed. Liquid floor wax makes a good parting agent. The mold is built up of layers of that hydrocal and water mixture and fiberglass mesh to produce a mold substantially in sheet form. The edges are trimmed to desired finished size.
After the mold has hardened, a model of the forward surface is made. This can be done by sculpture using clay to produce the shape that the finished product is to have. That completed, a second positive mold is made of the forward surface of the restoration. That second mold is also advantageously made of wetted hydrocal and fiberglass mesh. The second mold is hardened and the clay is removed.
The product of the effort to that point is a two-part, positive mold of the restoration. One part is a mold of the rear surface of the restoration and the other part is a mold of the forward surface. This specific arrangement is advantageous because it facilitates making the forward surface look uniform. It permits casting the restoration form by painting melted plastic on the inner mold surface or by introducing a quantity of molten plastic into one side of the mold and by putting the two parts together to fonn a complete hollow mold which is then rotated so that its interior surface is coated with the hot plastic in a slush casting process.
A small amount of pearl coloring is added to the plastic melt and is stirred into the melt so that it is evenly distributed. In the preferred form of the method, color is added by blowing cosmetic face powder of selected color on the inner surface of the cast while it is still hot. That coloring step is accomplished after one or more thin layers of vinyl plastic have been applied to the inner surface of the forward mold but before any attempt is made to add the rear mold. The face powder having been added, additional layers of vinyl are added. Since subsequently added plastic melt results in some melting of previous layers, the two parts of the mold need not be placed together until the forward and rear portions of the form have substantially the desired thickness. Then a quantity of melted plastic is placed in one-half of the mold; the two halves are placed together and the combined mold is rotated to add the final inner coating and to bond the two sections together.
The form is permitted to harden and the mold removed to expose what is then a hollow plastic form. That form is then cut open to permit insertion of a stuffing material. The cut is advantageously made on the rear side. Stuffing is inserted until the form is filled and has the desired resilience or substantially so.
Thereafter, a weight is inserted. The method of making a preferred form of weight was described above. When the weight is made of plastic of the same kind from which the remainder of the form is made, and particularly when they are both made of vinyl plastic, a small quantity of melted plastic inserted through the opening and applied to the rear surface of the weight permits bonding of the weight to the inner surface of the rear wall. This is easily done by orienting the restoration so that the weight presses down on the rear wall as the melted plastic hardens. A small quantity of molten plastic can be used to seal the opening. Alternatively, the
opening can be sealed by melting its edges together with a hot iron.
In the preferred method, before the form is closed its inner surface is painted with a brush to add nipple and areolia color. The product is realistic enough in appearance to make it feasible to provide even greater realism by painting representations of veins on the inner surface.
As a final step the outer rear surface of the prosthesis is provided with grooves or corrugations of the kind shown in FIGS. 4 and 5 using a metal comb which is sufficiently hot to melt the plastic surface. The comb is drawn over the surface slowly but steadily.
Although I have shown and described certain specific embodiments of my invention, 1 am fully aware that many modifications thereof are possible. My invention, therefore, is not to be restricted except insofar as is necessitated by the prior art.
I claim:
l. A prosthetic breast comprising:
a hollow form of soft plastic defining a shell having a rear wall shaped to complement the shape of the users chest and having a forward wall shaped like a breast;
a resilient wad of fibrous material filling said hollow form; and
a weight contained in the form and separated from said forward wall by said fibrous material;
said weight comprising a body of resilient material in which weights are imbedded and which is bonded to the interior side of the rear wall of said shell in the central region of its area.
2. The invention defined in claim 1 in which the forward wall of said form has a thickness between one sixteenth and three-sixteenths of an inch throughout the region surrounding its nipple and is made of transluscent plastic containing a quantity of pearl coloring.
synthetic fibers.
Patent Citations
Non-Patent Citations
Referenced by
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The Message audio Bible is now available on Bible Gateway! Click to learn more.
1:6 expanse. Describing the sky in terms of how it appears from the earth, the Hebrew suggests something flat and hard (Job 37:18; Is. 40:22). In vv. 6–8 it refers ambiguously to the atmosphere or sky (or both). Here it separates rain clouds from rivers and seas.


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The Marketplace Cafe presents... February Young Artists' Open Mic!
6:30 - 8:30 pm Sat, Feb 23, 2013
Venue: The Marketplace Cafe
53 North Street, Pittsfield, MA 01201Contact:
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The Marketplace Cafe presents... February Young Artists' Open Mic! Who? Any person aged 21 and younger What? An open forum for musicians, singers, poets, actors, puppeteers... anyone with a talent to showcase! Where? The Marketplace Caf�©. 53 North Street, Pittsfield MA When? Saturday February 23rd. 6:30-8:30 pm. Hosted by Katherine Winston!
5 Ways to Enjoy the Boston Harbor in Summer
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I am only 19 but I have two loving stepdaughters who both have kids of there own. I love watching my granddaughters but my family keeps telling me I need to start thinking straight and tell the girls I can't watch kids that are not mine. I try to explain to them that I don't see them as step kids that to me they are my girls and those are my grandbabys. They are starting to make rude coments when the girls are over how do I tell them to stop trying to make my girls hate me
Family trying to run my life grrrrr
Posted 04/06/2013
Wait what? Your dad married you guys!? At that age my dad would have shot the guy, this is just made for T.V kind of stuff
Posted 04/06/2013
Unless, of course, you're just a bored kid looking to have some fun trolling on a Saturday afternoon, in which case, go for it.
When you expect whistles, it's flutes. When you expect flutes, it's whistles.
Posted 04/06/2013
The more i look at this the more it blows my mind. Babies having babies,trying to play momma to babies that are the same age as you, two innocent little babies who are in the middle of it... Where was your dh when his 13 yearold was out having sex and getting.pregnant? And hes going to be a parent to your child now too...... im really at a lose for words here other then your in way way way over your head.... With no life jacket here
Posted 04/06/2013
Wait so u have a 3 yr old already?
katwalser · Original Poster
Posted 04/06/2013
Yes I have a 3 yr old but my son is not his we did not actually get together til I was 18
Posted 04/06/2013
Wow...what the hell
Posted 04/06/2013
Im not understanding wtf her personal life of how old is her dh why she marry young and blah blah blah have a damn thing to do with this!!! She asked for simple advice and yall bashing her for the fuck what!!!??? Im not understanding!!! Op tell your damn family mind there damn business point blank!!! Its not there life its yours!!! Damn yall some judgmental bitties on here!!!! Smh!!!
Posted 04/06/2013
So is it ok with you if your 14 year old daughter starts dating a 30 year old man now? Is it ok with your husband? What if the 30 year old man has a daughter with a child? Are you ready to be a great-grandmother?
I would like to forget anytime I was eyes to nuts, but these look like Donald Trumps nuts. Ginger comb over nuts. - Nuagent
Posted 04/06/2013
Sorry... But if my daughter got into a situation like this, I'd be trying to talk her out of it too.
But you are pregnant now so it doesn't matter
But you are pregnant now so it doesn't matter
Posted 04/06/2013
Ok so you're 19.... Been with him for 2 years...
I'm no math teacher but I know that 19-2 =17
I'm no math teacher but I know that 19-2 =17
What's on your mind?Create a new post
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Trade Me Browser Stats: March 2015
Once again we're pleased to share our browser and operating system usage data with you, fellow pixelsmiths and code craftspeople. Charts are below but here are our top-level highlights from the first ... more
This site showcases cool projects that the Trade Me technology team, our industry heroes and a plucky bunch of API consumers have sunk their hard work into. We encourage innovation internally through our regular FedEx days and through "pet project" time allocated to members of our tech team. We've built up our API to allow the New Zealand Internet community to do inspirational things with our platform that delight our members and we're proud to show off their work. Please take some time to browse through the projects, read about what we're up to and even follow us on the Twitters. Welcome to Labs!


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Pat Schatzline tells viewers of Sid Roth's It's Supernatural how to get your destiny in order and change your world. Do you have what it takes? read more
Charisma Magazine
Page 11 of 365
Why You Don't Have Supernatural Power
As members of Christ's body, we have Jesus' DNA. So why isn't His power working through us? Bill Johnson gives an explanation. read more
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If God is the same God in Africa as he is in America, why do we see so comparably little of the miraculous here in the United States? read more
10 Truths About the Gifts of the Spirit
Think there's only nine spiritual gifts? George O. Wood says a serious study of Scripture reveals gifts for the glorification of God, the reaching of the lost, the discipling of the found and the serving of human need. read more
Woman Walks After Four Years Confined to Wheelchair
For four years, Marie Cribbs' life was filled with pain. Wheelchair-bound as a result of complications from diabetes, two bouts of breast cancer and psoriatic arthritis, she couldn't lift her arms or legs and dealt with extreme pain every day. read more
Could This Be the Reason You Haven't Received Your Healing?
There's one surefire way the enemy can rob you of what belongs to you in Christ. Find out what it is and reject it! read more
WATCH: Darren Wilson Releases Full 'Holy Ghost' Trailer That Will Give You Goosebumps
"Finger of God, Furious Love, Father of Lights... Those films featured my narrative as more of a curious everyman, wondering about everything he sees. This movie... let's just say that I've finally made up my mind." read more
The Bible Truth About Angels
There are many different kinds of angels, but they really have only one purpose, and that is to help us. John Paul Jackson sheds light on these supernatural beings. read more
When Angels Intervene
Angelic encounters are far more common than most believers today realize. Here are firsthand accounts and personal revelations regarding these supernatural exchanges from six respected charismatic leaders. read more
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If God is the same God in Africa as he is in America, why do we see so comparably little of the miraculous here in the United States? read more
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Venus Williams leads U.S. in Hopman
Updated: December 30, 2012, 11:12 AM ETAssociated Press
PERTH, Australia -- Venus Williams and John Isner led the United States to a 2-1 victory over South Africa at the Hopman Cup mixed team competition Sunday.
Williams rallied to defeat 60th-ranked Chanelle Scheepers 4-6, 6-2, 6-3. After Kevin Anderson beat Isner 7-6 (0), 7-6 (5), the match came down to mixed doubles. Williams and Isner beat the South Africans 6-3, 6-2 to clinch victory.
Williams took some time to settle in against an opponent who rallied well and hit the ball deep. ...
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Legal highs awareness
Tuesday, 14 July 2015 | Newcastle
Improve your understanding of legal highs and therapeutically informed interventions for 1-to-1 working with substance users.
Meet, learn, collaborate - showcasing and developing the expertise of the sector.
Our national, regional and online events and training are an opportunity to network with other homelessness professionals - sharing knowledge, experience and solutions.
Tuesday, 7 July 2015 to Wednesday, 8 July 2015 | Hinckley Island Hotel
Two days of networking, learning and debate on the issues that matter to you. Book 3 places and get 10% off.
Thursday, 17 September 2015 | Norwich
One day course to help you develop the skills you need to support vulnerable clients with mental health issues.
Tuesday, 14 July 2015 | Newcastle
Improve your understanding of legal highs and therapeutically informed interventions for 1-to-1 working with substance users.
Wednesday, 2 September 2015 | London
Simple steps to make system administration easier. Get exactly what you need from In-Form.
Thursday, 3 September 2015 | London
Practical ways to improve the quality and impact of your data. Monitor client progress more effectively and prove the value and impact of your work.
Wednesday, 23 September 2015 | London
Develop strategies to safely deal with violent incidents and aggressive behaviour from the people you support.
Thursday, 1 October 2015 | London
Develop the knowledge and skills you need to work with drug and alcohol users.
Thursday, 8 October 2015 | Birmingham
Practical ways to reduce unplanned moves from your service.
Thursday, 22 October 2015 | London
Use the star to improve support planning and improve the impact of your service.
Tuesday, 17 November 2015 | London
Safeguard your clients effectively, in particular those who are at increased risk of abuse.
Thursday, 10 December 2015 to Friday, 11 December 2015 | London
Two day practical course on using motivational interviewing within your workplace.
Thursday, 17 December 2015 | Birmingham
Raise the confidence, motivation and communication skills of the people you support.


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Despite my fascination with far-off destinations, getting about my own home town helps me connect more with the environment and become involved in the community. I find it helps to have a little savvy with happenings close to home by reading local papers or simply googling say, 'what's on in Auckland' for instant information. 629 more words
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New discoveries
Exams and a study-related excursion have prevented me from writing lately. Such a shame, as I was already running behind on schedule. I am not mentioning this by means of an excuse as to why I haven't posted lately, but because the study excursion turned out to be a lot more succesful than I had expected. 700 more words
The news...
Okay, so, a lot has happened in a space of two to three weeks.
Biker Man and Wifey are moving. Yes, they are taking the two lights of my life (Cutie Pie and Noodle) and moving to a new suburb… 45 minutes away. 242 more words
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When the chips are down, and the fields go brown, I reach out to my side. There you are, close by.
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Where To Buy
Many 140x140x25mm axial fans tend to suffer from low static pressure, making them less suitable for use on CPU coolers or watercooling radiators with tight fin spacing. The NF-P14 on the other hand features a highly optimised nine blade impeller design thats following in the footsteps of Noctuas successful NF-P12 and has been carefully fine-tuned for both airflow/noise efficiency and outstanding static pressure. As a result, the NF-P14 lends itself not only to use as a case fan but also to high-impedance applications like CPU cooling.
Thanks to the use of Vortex-Control Notches, an advanced design measure first introduced with the NF-P12 fan, the NF-P14 is surprisingly quiet despite of its impressive airflow and pressure performance. The two Vortex-Control Notches at the trailing edge of each blade make the flows along the suction and pressure side mix more smoothly, allowing for less turbulence and velocity loss, which leads to increased efficiency as well as a significant reduction in noise emission.
Vortex-Control Notches not only allow the flows to join less abruptly at the trailing edge, but also serve the purpose of psychoacoustic optimisation by making the fans acoustic profile more pleasant to the human ear: Due to the Vortex-Control Notches, trailing edge vortices are split up into several smaller vortices, each having slightly different tonal characteristics. The fans airflow noise is thereby spread over a wider range of frequencies and, as a result, perceived as much less annoying.
The Vortex-Control Notches' effect of psychoacoustic optimisation is further enhanced by the staggering of the notches. As the Vortex-Control Notches are staggered from blade to blade, each blade creates a different vortex pattern, which also helps to better spread the fan's noise emission over the frequency spectrum and thereby contributes to the fans unobtrusive acoustic profile that easily blends into the background noise.
More information:
120mm & 140mm Mounting
NF-P14 Metal Reinforcements
01.07.2015 -
Test verdict:
"Prodotto ottimo!"
(Enrico Luperini, GameTechModding.com)
01.07.2015 -
Test verdict:
"Design sofisticati, materiali eccelsi e prestazioni da far impallidire la concorrenza sono ormai una costante in ognuno dei dissipatori targati Noctua. Ed i nuovi NH-D15S e NH-C14S non sono da meno grazie a strutture davvero robuste ed efficienti e a ventole estremamente performanti e silenziose."
(Alfonso Basilicata, NextHardware.com)
30.06.2015 -
Test verdict:
"The bottom line is that the Noctua NH-D15S is a solid performer, as well as offering fantastic compatibility which is aimed to help enthusiasts and consumers with large memory heatsinks, as well as PCIe slots;"
(Gavin Bonshor, Play3r.net)
30.06.2015 -
NF-S12B redux-1200 PWM
Test verdict:
"With this airflow and static pressure measured through the tests, the fan is definitely capable to deliver astonishing cooling performance, which will be able to keep every processor cool and stable, while being cooled by a CPU cooler or water radiator compatible with 120 mm fans."
(Dobrin Krastev, DVTests.com)
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Meet the Undergraduate Admissions Team
Wheelock's admissions counselors are here to help you make important decisions about your future. We know you're choosing among colleges, majors, and careers. It is an exciting time, but it can also be stressful. Our team is here to guide you through the admissions process and answer your questions about Wheelock, our programs, and your application.
Each applicant will work with a designated counselor every step of the way. To find your counselor, please call 617-879-2206 or email email@example.com.
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|Calvin Conyers
Acting Director of Undergraduate Admissions
Phone: 617-879-2260
Email: email@example.com
|Kaitlyn April
Undergraduate Admissions Counselor
Phone: 617-879-2396
Email: firstname.lastname@example.com
|Hannah Feintuch
Undergraduate Admissions Counselor
Phone: 617-879-2318
Email: firstname.lastname@example.com
|Eric Small
Undergraduate Admissions Counselor
Phone: 617-879-2204
Email: firstname.lastname@example.com
|Kara Widdison
Wheelock College Class of 2011
Admissions Visit Coordinator
Phone: 617-879-2206
Email: firstname.lastname@example.com