text: http://unix.stackexchange.com – I have a working server running Ubuntu 12.04 LTS (GNU/Linux 3.2.0-24-generic x86_64), including apache and php. Now I want to add curl support for php by running this: apt-get install php5-curl Sounds simple? No. I get this response: Reading package lists... Done Building dependency tree Reading state information... Done You might want to run 'apt-get -f install' to correct these: The following packages have unmet dependencies: linux-image-generic : Depends: linux-image-3.2.0-26-generic but it is not going to be installed php5-curl : Depends: libcurl3 (>= 7.16.2-1) but it is not go (HowTos)

subset: commoncrawl


text:
- 131Promote
Throw Pillow
crazy egosby Hugo Barros
Throw Pillow made from 100% spun polyester poplin fabric, a stylish statement that will liven up any room. Individually cut and sewn by hand, each pillow features a double-sided print and is finished with a concealed zipper for ease of care. Sold with or without faux down pillow insert.
S like SUPER! Great, Hugo!
Thank you my friend!!!
i like it too!
Thanks Daily!
fantastic Hugo
really great hugo
cool Hugo!! :D
Thanks gwenola, Mirco and Carina!
This is just otherworldly!
great hugo!
Great hugo.
☆ ☆ ☆ ☆ ☆! ;-)
Muchas gracias amigos. Appreciate it!
oHHHHHH love this one- must have missed. very nice work :)
Hugo your work is so on point and thought out. Its all truly amazing. You combine elements that inspire me so much.....love your works xxx
what's the original sculpture/form from?
See More Comments


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Eight pieces of delicious sushi: four pieces filled with shrimp tempura and fresh veggies, and the other four pieces filled with cream cheese and crab then fried. Each piece is finished with a variety of toppings: spicy tuna,crab mix, spicy shrimp, fresh avocado and five different sauces! 11.5 for a limited time.
Not available in Beverly Hills, Edison, Harrisburg, Hawaii, Key West, Las Vegas, Little Rock, Milwaukee, Monterey, Seattle and some international locations.
Locations throughout the United States, Latin America and Caribbean.
Your Benihana:Change Your Location
16226 Ventura Blvd.
Encino, CA 91436
Icon Title
Fri: 11am-3pm / 3pm-11pm
Sat: 11:30am-3pm / 3pm-11pm
Sun: 11:30am-3pm / 3pm-9:30pm
Reserve a Table
Although reservations are not required, they are recommended.
About The Encino, CA Benihana
Or visit our new sushi bar, where your sushi chef will prepare fresh nigiri, sashimi and specialty rolls, all with the same flair that made Benihana a legend in Japanese cuisine. The sushi bar is located adjacent to the renovated cocktail lounge where you can enjoy Happy Hour specials each Monday through Thursday from 4-7pm.


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Health & Parenting
Internet Safety for Kids
By Bob Tedeschi
Three years ago, when our daughter Rikki, then 17, shared a presentation on the dangers of kids exposing their personal information online, I was relieved to know our high schooler had a handle on this tricky terrain.
A few weeks later, on a whim, I logged on to my MySpace account, searched for Rikki, found her MySpace page, and then clicked on her friend Kristen's picture, which brought us to Kristen's page. There we could see that Rikki had posted, "Call me now!!!" Our home number followed — for Kristen and potentially the site's then 90 million other users to see, since Kristen had not made her page private. When we asked Rikki about it, she sheepishly admitted to having made an impulsive mistake and quickly asked Kristen to delete the post before the information could conceivably be used by stalkers, pranksters, or identity thieves.
Social-networking sites like MySpace and Facebook are incredibly popular with teens — recent surveys report that 71 percent of teens and 34 percent of 11- and 12-year-olds have a profile on a social-networking site (even though kids under 13 are not officially allowed on either site). Unfortunately, even the smartest kids — kids like Rikki, who know that you're not supposed to post private information online — make dumb mistakes on these sites, exposing themselves not just to predators and creeps, but also to bullying, identity theft, and other potentially negative consequences at school and, later on, in their work lives.
While it may be tempting to simply ban your child from using social-networking sites, a better strategy is to work with him to help him make smarter decisions online, says Monica Vila, cofounder of theonlinemom.com, a Web site devoted to educating parents about how to help kids use technology responsibly. (Teens whose parents have talked to them "a lot" about Internet safety are much less likely to take risks online, according to a Cox Communications survey.) Even if you are not on a social-networking site, or you have limited online skills, you can help your child avoid five of the most common flubs:


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Fri June 11, 2010
Wildfire On The Border
By KRWG News
New Mexico – A human-caused wildfire in the Chiricahua Mountains along the Arizona-New Mexico border still is only 25 percent contained after charring an estimated 2,600 acres.
Coronado National Forest officials said Friday that the projected date for full containment for the fire has been pushed back to July 10 instead of June 15.
The Horseshoe Fire was first spotted on May 26 and is burning in rugged terrain in a remote area. The fire still isn't endangering any structures.
Copyright 2010 The Associated Press.


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Cyclist Fight!
This happened just beyond the finish line at this weekend's Longsjo Classic. Based on the bib numbers, the guy throwing the punches is named Jerome Townsend, and the dude getting popped is named Dave Warner. »
This happened just beyond the finish line at this weekend's Longsjo Classic. Based on the bib numbers, the guy throwing the punches is named Jerome Townsend, and the dude getting popped is named Dave Warner. »
UFC women's bantamweight champion Ronda Rousey's next fight will be on Aug. 1, when she will take on Beth Correia. If Rousey's continued pre-fight trash talk is to be believed, Correia is in a world of trouble. »
Umpire and weirdo Jordan Baker defused a brewing Padres-Braves brawl with his best attempt at a double underhook throw on San Diego's Matt Kemp, who was attempting to go after Julio Teheran following a hit by pitch in the first inning today in Atlanta. »
The two videos embedded in this post are called "Beech Grove Walmart fight part 1" and "Beech Grove Walmart fight part 2." Each video carries the same YouTube description: "2 women and a kid fight at Walmart." I just want everyone to be clear on what they are getting into here. »
Josh Donaldson showed the Angels no Canadian hospitality today as it appears he shouted "Fuck you! Suck my cock!" at the L.A. dugout during today's game at Rogers Centre. »
A couple of boxing fans have sued Manny Pacquiao for allegedly failing to disclose a torn rotator cuff before last weekend's "fight of the century" against Floyd Mayweather. Pacquiao's team says he reported the injury to the Nevada State Athletic Commission, but a form he filled out prior to the fight indicates no… »
Professional golf got a shot of testosterone not seen since Tiger Woods's heyday when Keegan Bradley and Miguel Ángel Jiménez got all up in each others' faces yesterday at the WGC Match Play. Jiménez, who apparently missed his calisthenics, ended up beating Bradley in the match, after which ANOTHER close-faced… »
Major League Baseball has handed down suspensions for Thursday's benches clearing scuffle between the Royals and White Sox, and there are a bunch of them. Royals pitcher Yordano Ventura, whose taunting helped set-off the fight, was suspended the longest, for seven games. Teammate Edison Volquez got five games, as did… »
Days after nearly getting murdered on a baseball diamond by Mike Trout, Royals pitcher Yordano Ventura successfully started a fight after taunting Adam Eaton following the White Sox outfielder's come-backer. Some haymakers were thrown—a rarity in a baseball brawl—but few landed. »
The Canucks and Flames don't like each other. That much was obvious before coming into tonight's Stanley Cup playoffs game in Vancouver, one that ended in a 4-1 win for the Canucks and a third period box score that looked like this: »
This happened during this week's series between the Yankees and Orioles, and it provides a good lesson on how to become the "crazy one" in your group of friends. »
New video footage reveals more about January's bar fight involving Eastern Kentucky lineman Colton Scurry and Kentucky football players . Not only did Scurry initiate the fight, but later that night, a different EKU player punched a Kentucky quarterback in the head in a dorm lobby on EKU's campus.
What you are watching is a brief portion of a freestyle wrestling match that took place at Far Eastern Federal University in Vladivostok, Russia. I don't know if anything preceded this little scuffle, but I imagine the guy in red was getting worked, because those are the kicks and slaps of a desperate, frustrated man. »
Yesterday, Emir Spahić's Bayer Leverkusen lost to Bayern Munich in the DFB Pokal. While doing interviews after the match, Spahić apparently witnessed some of his homies he'd brought to the stadium tussling with security. Because he's really 'bout that life, he ran over to join the scrap. »
Phil Kessel and David Booth got into a shoving match during today's Maple Leafs' practice. The brouhaha didn't escalate to punches, however, and teammates separated the two players. »
It's hard to believe that the knob in this video, who embodies every spring break stereotype—neon tank top, bad sandals, dumb sunglasses, urging other bros to come at him while he backs away—is even real, but here we are. I won't spoil what happens, but get ready to wish you had been there to laugh in this guy's face. »
"OY, AN' WOT 'ID I 'EAR YOU SAY ABOUT ME MUM?!" one West Ham fan presumably asked the Sunderland fan across from him. Squaring up, the Sunderland hooligan probably said, "YOU 'EARD ME, MATE. ME AN' ME LADS GAVE OL' MUMSIE A GOOD BOFFIN', BUT YOU'RE GONNA LOOK EVEN WORSE THAN THAT OL' HAG WHEN WE'AH DONE WIF YOU!" »


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Because it performs its functions in real time, the system can be used to convert from telecine, tape or disk in the time it takes for dubbing. The Ukon also features real-time aspect ratio conversion as part of this process so that SD copies created from an HD master telecine can be panned, scanned, zoomed and tilted to suit.
The Ukon provides upconversion, downconversion, and cross-conversion either separately or in any combination. Designed to handle different frame rates, image sizes, and aspect ratios, the system includes features such as tilt, pan and zoom, time code conversion with precise frame mapping, comprehensive audio handling, and 3:2 cadence detection and repair.
For more information, visit www.snellwilcox.com.
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An Inside Look at Four Virtual Reality Start-Ups
What Moves the Social TV Needle?
Mark Kudsi Directs 'Art of Patron Virtual Reality Experience'
BT Renews Intelsat Deal
Top Twitter TV Shows for 2014-15 Season Unveiled
comScore Introduces MobiLens Plus
North Korean Propoganda Art Inspires the Credits of 'The Interview'
Imaginary Forces Creates Kaleidoscopic Titles for 'Bosch'
Filmmaker Embraces Short Documentary Format with Oscar-Nominated 'Crisis Hotline'
North Metro Television Goes Wireless with Comrex LiveShot
Spectra Logic and HauteSpot Networks Introduce Body-Worn Camera Video Surveillance Solution
Huge Ultra HD Display Lights Up Times Square


text:
- Producer Jerry Weintraub Dead at 77; Film & TV Titan's Credits Included Ocean ... - E! Online
- Amanda Peterson's Death: Sarah Michelle Gellar, Scott Foley, Lance Bass ... - Us Magazine
- Justin Bieber Strips Naked to Bare His Butt on a Boat! - E! Online
- Mako Tacos and Other Bites on the Menu for 'Shark Week' - ABC News
- Miss Universe Paulina Vega refuses to give up her crown - Economic Times
- Kourtney Kardashian reportedly dumps a hard-partying Scott Disick - Los Angeles Times
- Back on? Katy Perry and John Mayer spotted together - Fox News


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BLOG: The (technology) pluses and minuses of a GM-FCA deal
11:15 am U.S. ET | June 30, 2015
GM and FCA could benefit from each other's technology. Instead of a full-blown merger, maybe some small side-deals is all Sergio needs.... Read More »
FCA recalls small number of SUVs over suspension complaint
6:28 am U.S. ET | June 29, 2015
Fiat Chrysler Automobiles is recalling a small number of new SUVs that may have been equipped with improperly heat-treated suspension components.... Read More »
Fiat Chrysler's Jeep delay highlights challenges to a potential merger
June 29, 2015 10:50 CET
The chief of Fiat Chrysler Automobiles' Jeep brand, Mike Manley, says a redesign of its Grand Cherokee SUV will be delayed by at least a year, intensifying the challenges FCA CEO Sergio Marchionne faces in his quest for a partner.... Read More »
Dodge to build more Hellcat engines
12:01 am U.S. ET | June 29, 2015
Fiat Chrysler plans to substantially increase production of the popular 707-hp Hellcat engines. Tim Kuniskis, head of the Dodge and SRT brands, said the additional V-8 engines will help Dodge catch up to a "huge flood" of orders for Hellcat-powered versions of the Challenger and Charger.... Read More »
Grand Cherokee redesign delayed at least a year
11:12 am U.S. ET | June 26, 2015
Jeep brand CEO Mike Manley said a redesign for the popular Grand Cherokee SUV will be delayed to late 2018 or 2019, after initial planning for 2017.... Read More »
BLOG: Colorado, Canyon target 'best' marketing claim
3:00 pm U.S. ET | June 26, 2015
Soon, Chevrolet and GMC will gain a coveted marketing claim: Best fuel economy of any pickup.... Read More »
FCA to recall 164,000 Jeep Cherokees
1:46 pm U.S. ET | June 25, 2015
Fiat Chrysler Automobiles is launching a voluntary recall of about 164,000 Jeep Cherokee SUVs globally to install shields that protect the power liftgate control components from moisture.... Read More »
Kerkorian kept the pressure on Detroit 3
12:01 am U.S. ET | June 22, 2015
Kirk Kerkorian, who died last week, never quite managed to close the blockbuster deals he chased in Detroit. But his deep pockets repeatedly prodded auto executives into action, and his warnings of looming trouble for the Detroit 3 proved uncannily accurate.... Read More »
FCA hikes Ram diesel torque rating for 2016
12:01 am U.S. ET | June 22, 2015
Fiat Chrysler Automobiles' Ram division is firing the opening salvo in the 2016 model pickup wars by boosting the torque rating of its high-output, 6.7-liter diesel engine to 900 pounds-feet -- highest in the industry.... Read More »
Eberspaecher, GKN, Marelli have key parts in new Fiat 500X
12:01 am U.S. ET | June 22, 2015
Eberspaecher, GKN Driveline and Magneti Marelli contribute key parts to the new Fiat 500X that include its NOx-reducing catalytic converter, rear-drive module and power transfer as well as its halogen and Xenon headlights.... Read More »
Kirk, Lee and the one that got away
12:01 am U.S. ET | June 22, 2015
When billionaire investor Kirk Kerkorian set his sights on acquiring Chrysler 20 years ago this summer, he effectively pushed the automaker into its tie-up with Daimler three years later.... Read More »
Dodge plans to produce '17 minivan
12:01 am U.S. ET | June 22, 2015
The death of the current-generation Dodge Grand Caravan may have been greatly exaggerated. According to company documents, Fiat Chrysler plans to continue production of the current Dodge people hauler at least into the 2017 model year.... Read More »
BLOG: UAW chief's credibility, legacy on the line with Tier 2
12:25 pm U.S. ET | June 19, 2015
UAW President Dennis Williams flashed an unmistakable determination to solve the union's Tier 2 dilemma during this year's contract negotiations with the Detroit 3.... Read More »
UAW leaders intent on bridging the gap in auto workers' pay, Williams vows
12:50 pm U.S. ET | June 18, 2015
UAW President Dennis Williams, using his final press conference before the start of contract negotiations with the Detroit 3, today vowed to address the pay disparity between entry-level workers and longtime auto workers meaningfully in this year's round of bargaining.... Read More »
BLOG: Who was Kirk Kerkorian? He was a money man
12:01 am U.S. ET | June 18, 2015
It was always about the money for Kirk Kerkorian, the auto industry provocateur who died Monday at 98.... Read More »
Kirk Kerkorian -- investor who changed Chrysler, prodded GM -- dies at 98
10:59 am U.S. ET | June 16, 2015
Kirk Kerkorian, the billionaire casino mogul who twice attempted takeovers of Chrysler and in 2006 tried to fashion a global alliance between GM and Nissan-Renault, died Monday in Los Angeles.... Read More »
BLOG: Kerkorian-Iacocca tag team hit Chrysler execs with a reality check
1:45 pm U.S. ET | June 16, 2015
Kirk Kerkorian took a run at Chrysler in 1995 when he launched an unsolicited $20 billion takeover bid. Perhaps even more astounding was whom he had teamed up with: Lee Iacocca.... Read More »
UAW begins talks with U.S. automakers in July
2:03 pm U.S. ET | June 15, 2015
The UAW, seeking to close the pay gap between veteran and newer workers, will begin formal negotiations with the biggest U.S. automakers next month, union Vice President Jimmy Settles told reporters today.... Read More »
The compact crossover takes the king down a notch
12:01 am U.S. ET | June 15, 2015
In the second half of 2014, sales of compact crossovers were rapidly catching up with those of midsize sedans, long the category king in the U.S. But through the first five months of 2015, the crossovers have nudged ahead by about 3,500 units.... Read More »
Daimler to recall 40,000 vans in U.S. to replace faulty airbags
11:04 am U.S. ET | June 13, 2015
Daimler made 40,061 vans from 2005-08 with airbags that must be replaced, the National Highway Traffic Safety Administration said.... Read More »
Dodge brothers return in a new set of ads
2:51 pm U.S. ET | June 10, 2015
Dodge is going back to its roots again in a new round of Dodge Brothers commercials, which launch this week. The four ads highlight the 2015 Dart, Durango and the Scat Pack trims of the Challenger and Charger.... Read More »
BLOG: A prescient meeting with Al Iacobelli
4:17 pm U.S. ET | June 9, 2015
In 10 years of covering UAW negotiations for Automotive News, a face-to-face conversation I had with Al Iacobelli in 2011 stands above the rest.... Read More »
Fiat Chrysler labor chief Iacobelli retires as UAW talks loom
12:04 pm U.S. ET | June 9, 2015
On the verge of UAW negotiations, Fiat Chrysler said Al Iacobelli -- its head of North American employee relations -- is retiring and is being replaced with the HR head in Mexico. Iacobelli, 55, who has been a key driver of Chrysler's labor relations for more than a decade, "has announced his plans to retire from the company" effective immediately, FCA US said in a statement today.... Read More »
BLOG: Lifting the curtain on the Jeep Grand Wagoneer
11:30 am U.S. ET | June 9, 2015
When it returns for the first time since 1991, the Jeep Grand Wagoneer will be a unibody vehicle, and not a body-on-frame, truck-based SUV like the Chevrolet Suburban or Cadillac Escalade.... Read More »
Ram prices 1500 Rebel trim at $43,985; Laramie Limited to start at $51,870
12:01 am U.S. ET | June 9, 2015
Ram says pricing for its freshened 2015 Ram 1500 Laramie Limited will start at $51,870, while pricing for the 2015 Ram Rebel, a new half-ton trim level, will begin at $43,985.... Read More »
Newsletters & Alerts
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Published 07/26 2013 04:10PM
Updated 09/01 2013 08:21PM
Image is updated every 15 minutes.Image is updated every 30 minutes
Copyright 2015 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
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Learn how to shoot and edit green screen footage and images.
Shows how to create stunning imagery in Photoshop in the shortest time possible.
Shows how to create eye-catching designs and graphic art in Photoshop, in the shortest time possible.
Provides in-depth training on Camera Raw 6, the CS5 component that enables photographers to open and manipulate images more flexibly and efficiently.
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7th Global Film Festival 2014
The 7th Global Film Festival Noida will take place on 11, 12, 13 November at Marwah Studio, Film City, Noida in which film makers from all over the world will showcase their films and participate in exhibitions, workshops, seminars which will highlight the latest developments in the field of Cinema. There will also be fashion shows, cultural events, musical and dance performances, photography and painting exhibitions and presentation of awards for excellence in the various fields of Cinema.
Watch Live Coverage of Global Film Festival Noida 2014


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NYC Parks Events Calendar
Get up, get out, and do something! Just about any day of the year, you can find something fun, informative, and healthy to enjoy at an area park. Feel free to browse the listings below, or use the search tools to find an event that matches your interests and location.
Viewing 21–30 out of 4,295 events
from July 4, 2015 to April 25, 2026
Saturday, July 4, 2015
Free Yoga
at Target Bronx Community Garden, Bronx
10:00 a.m.–11:00 a.m.
Join us for yoga in the garden. All levels of experience are welcome.
Category: Fitness, Outdoor Fitness
Free Yoga
at Target East Harlem Community Garden, Manhattan
10:00 a.m.–11:00 a.m.
Join us for yoga in the garden. All levels of experience are welcome. Mats are provided for one-time use during class.
Category: Fitness, Outdoor Fitness
CANCELLED: Bryant Park Fly Fishing
at Fifth Avenue Terrace (in Bryant Park), Manhattan
10:00 a.m.–12:00 p.m.
Learn the basics of fly fishing for free. Join expert instructors from Orvis for lessons of fly casting and outfit rigging.
Category: Education, Nature
It's My Park at Claremont Park
at Claremont Gazebo (in Claremont Park), Bronx
10:00 a.m.–12:00 p.m.
This It's My Park season, volunteer with the Parks Department gardening team every Saturday morning, to do landscape maintenance at Claremont Park. For more information or to…
Category: Volunteer, It's My Park
Summer Exhibitions at Socrates Sculpture Park
at Socrates Sculpture Park, Queens
10:00 a.m.–8:00 p.m.
Public art projects by Agnes Denes, Heide Fasnacht, Gabriela Albergaria, Verta Lutter and IK Studio. On view through August 30th.
Category: Art
Stories at the Statue of Hans Christian Andersen
at Hans Christian Andersen Statue (in Central Park), Manhattan
11:00 a.m.–12:00 p.m.
Therese Plair will tell the Caribbean story "The Pumpkin Rider." Dovie Thomasen will tell the Lakota story "Iktomi Saves the People," and Laura Simms will tell the Romanian story "The Empress of Fairies".
Category: Kids
Free Yoga in the Park
at Socrates Sculpture Park, Queens
11:00 a.m.–12:00 p.m.
Yoga classes are free and designed for all experience levels. Participants should wear comfortable clothing and, for yoga, bring a mat or a towel. Kripalu Yoga is a system of Hatha…
Category: Fitness, Waterfront, Outdoor Fitness
Central Park Tour: Conservatory Garden
at Vanderbilt Gate (in Central Park), Manhattan
11:00 a.m.–12:15 p.m.
Take a tour with Conservatory Garden staff and learn about the history of the only formal garden in Central Park, including its restoration by Central Park Conservancy.
Category: Nature, History, Tours
Central Park Tour: Heart of the Park
at East 72nd Street and Fifth Avenue (in Central Park), Manhattan
11:00 a.m.–12:30 p.m.
Visit some of the park's most famous landmarks, including Conservatory Water, Bethesda Terrace, and the Lake, on this east-to-west tour led by Central Park Conservancy guides.
Category: History, Tours
Bryant Park Juggling
at 42nd Street Plaza (in Bryant Park), Manhattan
11:00 a.m.–2:00 p.m.
Test your coordination and dexterity with free juggling lessons in the park. All skill levels are welcome to join in the fun. Equipment is provided.
Category: Games
Related Information
- Get information on upcoming events directly in your inbox by signing up for our Email Newsletters.
- Know about an event that's not on the calendar? Send us a tip!
- Planning an event and considering hosting it in a park? Make sure to read our Planning an Event page.


text: My husband and I booked into Nuts End B & B for three nights and were thoroughly impressed. The accommodation is beautifully decorated with lots of room. Wendy's breakfasts are amazing, with home made Bircher muesli and jams, selections of cereal and a delicious cooked British breakfast! I can honestly say this is the best B & B I have... More


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Results 1 to 5 of 5
Thread: Halo 2 leaked
October 14th, 2004 #1
Halo 2 leaked
there are many more articles on this. this one was just the quickest to grab.
- Similar Threads
- Intuos 5 leaked
- Quake 4 Leaked Concept Art
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Hide this ad by registering as a memberOctober 14th, 2004 #2
- J t J -
Fading Oasis
<(^ ^)>
October 14th, 2004 #3
just like doom3 and half-life2...
damn them!
in fact i could care less for halo and halo2...
Do you know the muffinman?
Originally Posted by creatix
Once you understand what the word "stupid" means - age is no longer a valid excuse for being that way.
October 14th, 2004 #4
its a 3 GB file and its in French!
Last edited by Denart; October 14th, 2004 at 08:35 PM.
October 14th, 2004 #5
IRC is the storage room of the world...
Get anything you want on it.


text:
Forum - View topicANNCast - Macek Training
Goto page 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 Next
Note: this is the discussion thread for this article
|View previous topic :: View next topic
Posts: 6537
Location: Penguinopolis
I can't hear half of what Macek is saying in this.
Nice to know that he's still rage-inducing well into the twenty first century.
|Back to top
ANN Executive Editor
Posts: 7364
Location: Snake Mountain Cocktail Lounge
He's a little quiet but talks for long stretches, so just turn your audio up.
|Back to top
Posts: 18
|Just a quick question about the theme: this may be asking a bit much, but is there anything that is preferred? Upbeat, Ska, Symphonic? Just trying to get a hint of what you two actually want.
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Posts: 81
Location: Chicago
|About fifteen minutes, or so, ago I logged on and the Carl Macek ANNcast was listed I checked a couple of other item and by then it disappeared. - Is it me? Or did something go awry?
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ANN Executive Editor
Posts: 7364
Location: Snake Mountain Cocktail Lounge
We're recompressing it so Macek's audio is louder (that's what I get for editing it in a very quiet room). It'll be back and more listenable in just a few.
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Posts: 5058
Location: Fresno, TX
|the guy talks so low... even after the update, i still had to put my volume up higher. interesting content, though.
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Posts: 1431
Location: In the Library with Philip
Edit: It's much more listenable now. Thanks!
Last edited by poonk on Fri Jan 15, 2010 1:47 am; edited 1 time in total
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Posts: 380
I really liked your little theme song. It's kinda cool lol. But hey whatever, let's see what else you guys get...
About 2 hours 10 minutes...I better get comfortable lol!
The whole Voltron thing...that's where John O'Donnell got his start too. He was working for whoever was doing that show. That's so weird that everything seems to go back to that show. Guess if it weren't for Voltron we wouldn't have CPM and Robotech might not have come out. WoW...odd Never saw it myself lol.
I did see some of Robotech though. Never really got into it though. That shows really before my time, and I guess that's that. I did like it, but it's not anything I really went gaga over. I also saw some of the original (Macross? Southern Cross one of those) and really don't know/remember what was what anymore. Liked them all, but not really anything I want to watch more of.
On sales of anime: "Maybe even a decline?" A fall off a cliff perhaps...
ADV, CPM, Streamline and U.S. Renditions...ah the companies that made the industry what it is today...Urotsukidoji: sold as much as something big Streamline had? LOL. That was in the movies though, so that makes sense.
ADV the mircrosoft of anime...hehe.
The three beep thing...yeah I heard a some of ADV actors disliked that since they never used to do that. I don't think that they "didn't know how to do ADR", it was more like they were kinda doing their own things though, in their own way. Guess it might not be the best way to do it lol...
I don't think ADV thinking more fan oriented was totally a bad thing. Because hey they really cared about their fans, hell over their profits sometimes. And hey I'm a fan .But that was the real problem, you can never run a company where profits aren't very important. I love them for putting out so many amazing shows, some of my all time favorites, even though they sold terribly. But that really hurt them. And they should have been paying attention the mainstream a little more perhaps, but I can't fault them for careing about the hardcores...I place more of the blame on the hardcores for not supporting them then ADV themselves. I mean how can you blame ADV for giving the fans what they want?
Macek likes dark stuff/thrillers etc. ? Cool me too!
Ehh...I really like ADV dubs, going all the way back to their old stuff. They were always the best studio out there dubbing. I never found any of their dubs "unnatural".
Roujin Z yeah...it's such a weird thing for him to be credited on lol. I own the DVD though. It's a decent movie, but nothing that great. Oh and that's sooo weird that people working at Sony have no idea what their doing with the sound. You'd think the people in Japan whose job it is do music/sound at Sony would have some clue lol. As far as the dub goes, it's one of the very few Bakewell dubs I'm not much of a fan of too . He's done much better, like Dominion Tank Police, A Wind Named Amnesia and Cyber City...). I like the little extra feature thing on CPM's DVD though, where it's like a little trivia game about the movie. Whoever came up with that at CPM, props. Cool little thing . Nothing amazing, but hey I liked little stuff like that sometimes. Shows some effert, at least there's ONE extra feature on the DVD...
Last edited by Prede on Fri Jan 15, 2010 1:53 am; edited 3 times in total
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Hunter Sopko
Posts: 236
Wow. That was a great interview. So very, very informative on so many topics, especially the nebulous pre-CPM/ADV/etc era. The Harlock story at the end I think took the cake, honestly, but it's always fun hearing about the dysfunctional environment that was ADV.
I remember liking COPS. Campy fun.
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Much, much better. Thank you very much.
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I can't thank Macek for much. Never having grown up on Robotech, my first exposures to the franchise was through Macross Plus, Frontier, and the original before I watched the others. A lot of people tend to say that Robotech really made anime into this big thing, but looking back, it never seems that way. Shows like Voltron, Star Blazers, and Robotech were all fun and nice and what not, but did people really know that these things were actually Japanese? It feels like that that aspect didn't start to become bigger until the early 90's when shows started coming out in more uncut forms, retaining the Japaneseness of the production.
Robotech is an anomaly now, it's not really relevant aside from a few crappy sequels, and the franchise is holding on by a diehard string. With no one growing up on it, and no else really entering into the fanbase, I can't imagine it lasting too much longer. It really is just an 80's cartoon in the end, locked into the 80's.
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Location: Penguinopolis
Carl Macek didn't invent anything. He slapped together three unrelated anime and gave it a title. If I slap together Death Note and Monster, and call it Psychopaths, am I an inventer? I'll say as much as Robotech was a lot of people's introduction to Macross, and anime in general, but Macek and Harmony Gold has been a hinderance to a lot of Macross fans for years.
You do have to admire some of the marketing creativity, though. But that's the only creativity he has.
And maybe it's because I'm biased against him, but he has a very creepy-sounding voice. It sounds almost like Emo Philips.
There are plenty of leitmotifs in Macross, Macek has no effing clue what he's talking about.
My god, I remember C.O.P.S.! It was so bad, but it passed the time and the toys were okay.
John K. is a douchebag. He's so snooty, putting down all cartoons that aren't traditional "wacky antics" shows. He says that cartoons should never be serious. I loved Ren and Stimpy, but some of the things he says on his blog and elsewhere is pretty disgusting. I'm glad that since Ren and Stimpy, his career has been an utter failure.
Hey John, Billy West was an even better Ren than you ever were. Eff off.
Those Lupin III dubs from Streamline were godawful. Context be damned, bad is bad. Point me to the halfwits who appreciate those.
"Derp, cartoons are all dubbed anyway, why have subtitles?" Because it's foreign film, you splooge stain.
Tapeworm is a proper name for something Macek is involved in.
Oh good, it sounds like the police are coming to take Macek away.
What made ADV think hiring Carl Macek, already a revilled figure in the anime community, was a good idea? ADV dubs were already mediocre at best, but bringing in Macek?
If you think ADV dubs were any worse than Streamline ones, you have a short memory.
The Dubine dub/subtitles are widely panned by pretty much anyone who has encountered them. Letting Macek handle that was a huge mistake. That you laughed off what he said about that makes me vomit a little in my mouth.
"I'm a story teller". Yeah? Well the stories are already told. You're not supposed to tell stories. They've been told. You just have to bring them to us. You want to tell stories? Write a [expletive] book.
He really seems to think that Robotech is superior to Macross because it sold a lot. Macek, nostalgia is a powerful thing. That's all I have to say about that.
If his philosophy is taking your time and doing things right, why has he never done so?
It's like he doesn't know he's a complete joke in the anime fandom.
Last edited by penguintruth on Fri Jan 15, 2010 4:05 am; edited 5 times in total
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Location: Fresno, TX
|finally finished the whole podcast... wow. this guy's like the Rob Liefeld of anime. i don't fault him, though. i mean a job's a job. still... damn
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Hunter Sopko
Posts: 236
Leaping over the massive chip on your shoulder, I would argue that it's more a problem with Dunbine just kinda being a boring, terrible show. The best dubbing/script in the world wouldn't save it. You're taking the wrong lesson away from it, anyway. The story wasn't really meant to be him leaping to save this poor show, it was more to showcase the amateur atmosphere that he was subjected to at ADV.
Anyway, Harmony Gold has always been on my bad side not because of anything Macek did, but because I'm a rabid Battletech fan and Harmony Gold just can't/won't stop with the Unseen mechs. (How do you approve their redesigns for use in products to the consumer, then turn around and sue them again when they decide to actually use them? We'll never see Mechwarrior 5 at this rate...)
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Determining the Best Ghost in the Shell
A new Ghost in the Shell movie has hit theaters in Japan, which means it's time to look back at the entire series and finally decide: which version of this cyberpunk classic is the all-time best? ― Firstly: I'm not here to argue whether Ghost in the Shell is the one of the best anime of all time. We already know it is. That first film? It was the best. The TV series? Also the best. And this new film ...
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Biltmore CabaretAugust 13, 2011Music Venue • Vancouver, Canada
Best door man in town. Be sure to give #1 some love when you are there
Best door man in town. Be sure to give #1 some love when you are there
Always fun at The Biltmore. Whether it is a band on tour or one of the awesome weekly parties.Kinda like my home away from home.
The sweet sambal wings are a must buy when you come here. Grab a glass of MOOSEHEAD too
Keep aware of your surroundings since the ATM is outdoors.
The lunch special is always delicious & only $8 daily. Add a garlic naan to it & you have a full belly for under $15 DT
Great live music venue downtown but the shows always start early...
hands down one of the best Caesars in Vancouver.
If upstairs open, skip the wait & go to the washroom upstairs. Men & women ;-)
No booze allowed in the auditorium. You need to drink in tie lobby.


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Turkish Officials Fend Off Disclosures
Turkish officials fended off disclosures from leaked U.S. diplomatic cables that painted its prime minister as a distrustful authoritarian and its foreign minister as dangerously Islamist, and alleged its finance minister had dispensed stock tips.
Amid the caustic U.S. assessments of several foreign leaders revealed in State Department cables released by WikiLeaks beginning this weekend, the diplomats' takes on Turkey's officials resonated within the country and fed into its already divisive national politics. Analysts said that while the dispatches were embarrassing, however, neither side was likely to let them become a game-changer in their relations.
Turkey's foreign minister, Ahmet Davutoglu, on Monday shrugged off leaked communications that described him as an "exceptionally dangerous" Islamist with imperial delusions.
A Timeline of WikiLeaks
Key releases, legal battles and other significant moments in the history of the website and its founder.
Highlights from Leaked U.S. Cables
Read quotes from some of the leaked documents.
"Turkish-American relations will not be affected," Mr. Davutoglu told reporters in Washington after a meeting with U.S. Secretary of State. He said Mrs. Clinton had apologized for the leaks, according to CNN Turk, but added "it is correct to depict this as the 9/11 of diplomacy," the TV channel reported.
The leaks received heavy coverage in Turkey's media Monday. That, analysts say, was in part because of the sheer number of documents related to Turkey— close to 8,000 cables came from the U.S. Embassy in Ankara alone—and because of the way they played into Turkey's internal debate over the Islamic-leaning Justice and Development Party, or AKP, and its leaders.
On Monday, Turkey's finance minister, Mehmet Simsek, denied a comment in one of the U.S. embassy cables that in 2008 he had urged foreign investors to sell stock in Turkey's largest media company, Dogan Yayin Holding AS, as it became locked in a tax battle with the government.
Mr. Simsek told a group of investors in London to sell stock in Dogan because it "won't be around much longer," according to the cable. Its U.S. diplomat author outlined the growing dispute between the Dogan group and Prime Minister Recep Tayyip Erdogan's government.
"There are suggestions of a deliberate political move against Dogan," the cable said. "Indeed, after Prime Minister Erdogan's attacks began last week, Dogan stock fell 8%."
Mr. Simsek, a former Merrill Lynch banker with a strong links to the international investor community, said in a statement thatthe allegations were "baseless" and "fabricated." He pointed to an error in the document, which incorrectly identified his 2008 post as "trade minister," as evidence that its contents couldn't be trusted.
Turkey's opposition Republican People's Party leapt on the claims against Mr. Simsek, demanding an investigation. Daily newspapers such as the Dogan-owned Milliyet highlighted excerpts from the assessments of U.S. diplomats and their sources that chime closely with the views of Mr. Erdogan's secularist opponents in Turkey.
Those assessments included one in a 2004 cable that referred to Mr. Davutoglu's Islamist influence on Mr. Erdogan and said Mr. Erdogan himself was an "authoritarian" surrounded "by sycophantic (but contemptuous) advisers." A more recent cable mocked Mr. Davutoglu's talk about restoring the influence of the former Ottoman Empire.
With thousands of Turkey-related documents still unpublished, speculation continued to swirl Monday on TV talk shows here that cables yet to be revealed would show that the U.S. supported anti-Turkish terrorists from the Kurdish Workers Party, or PKK, in Northern Iraq. That is a potentially explosive claim that U.S. diplomats have denied in advance.
But failing some future bombshell, Turkish leaders will draw the distinction between diplomatic cables and policy, said Ilter Turan, professor of international relations at Bilgi Univeristy in Istanbul.
Mr. Turan also pointed out there was an upside to the leaks. Cables from early in the government's tenure, soon after the AKP had taken power and when Turkey had just rejected U.S. requests for help in its invasion of Iraq, were far more critical and dismissive than more recent ones. Later cables accept the insistence of Turkish leaders that they aren't turning from the West by adopting a foreign policy that sometimes conflicts with that of the U.S. in the region, but merely re-engaging with their neighborhood.
"There may have been questions about what Turkey was doing and where it was going, but it was not at the level of policy," said Mr. Turan. "I think on whole both parties will work to make sure damage to an already strenuous relationship is limited."
—Joe Parkinson contributed to this article.
Write to Marc Champion at firstname.lastname@example.com


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I have a bunch of files in a directory. I want to zip some of them together into a zip archive.
I can see there are various solutions for doing so. I could use a gem such as rubyzip or run
exec and just use a command line tool.
This is going to impact an important part of the system I'm working on so I'd love to have some feedback and/or directions on creating zip files with Rails.


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Bangladesh factory collapse: Hanufa Begum, the mourner
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Hanufa Begum, 66, lost her daughter, Sakhina, 22, who worked on the eighth floor of the Rana Plaza at the New Wave Style factory. She has received no compensation from the government and only a small amount from an aid agency.
By all accounts, Sakhina Begum was the perfect daughter. She worked every day of the week, earning enough to care for her widowed mother — even declining marriage proposals so her mother would not be alone.
"I was lucky to have a daughter like her," says Hanufa Begum.
"Now, I have nothing."
Hanufa wails loudly, beating her chest, covering her face — her grief still raw.
Sakhina had worked in garment factories for seven years, moving to New Wave Style last year.
The $90 she earned each month meant her arthritic mother didn't have to do domestic work. Mother and daughter had enough to buy food and rent a one-room shanty fashioned from sheets of corrugated steel.
The day before the collapse, Sakhina spoke about the cracks in the plaza's walls. She was scared, but everyone was told to come to work or not get paid.
"She said the rent was due in a week and she needed the money," Hanufa says. "I wish I had forbidden her from going."
Hanufa was cooking fish curry in the communal kitchen when her neighbours started shouting about an accident at the Rana Plaza. When she arrived there was a gap — a forbidding mound of rubble — where the eight-storey building once stood.
Bloodied women struggled to climb free as rescuers dug out one person after another. But not Sakhina. Never Sakhina.
Each day for the next five months Hanufa returned to the ruins.
"I know I go for nothing, maybe just to cry, but I have to go," she says. "I want to give her a funeral."
She doesn't listen to neighbours, who tell her there is no one else beneath the rubble. More than 300 bodies, which were so badly decomposed that they were unidentifiable, were buried in a mass grave.
Hanufa has returned to work as a domestic, where she works for food and a couple hundred takas a month — about $3.
"All I am left with is this paper," she says.
It is a crumpled identification paper that New Wave Style gave Sakhina when she joined: a black-and-white photo of a young woman, her hair pulled back, staring intently at the camera.
Raveena Aulakh
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Are you Per Höllsberg?Claim your profile
Publications (71)353.35 Total impact
Article: The DR6 protein from human herpesvirus-6B induces p53-independent cell cycle arrest in G2/M[Show abstract] [Hide abstract]
ABSTRACT: HHV-6B infection inhibits cell proliferation in G2/M, but no protein has so far been recognized to exert this function. Here we identify the protein product of direct repeat 6, DR6, as an inhibitor of G2/M cell-cycle progression. Transfection of DR6 reduced the total number of cells compared with mock-transfected cells. Lentiviral transduction of DR6 inhibited host cell DNA synthesis in a p53-independent manner, and this inhibition was DR6 dose-dependent. A deletion of 66 amino acids from the N-terminal part of DR6 prevented efficient nuclear translocation and the ability to inhibit DNA synthesis. DR6-induced accumulation of cells in G2/M was accompanied by an enhanced expression of cyclin B1 that accumulated predominantly in the cytoplasm. Pull-down of cyclin B1 brought down pCdk1 with the inactivating phosphorylation at Tyr15. Together, DR6 delays cell cycle with an accumulation of cells in G2/M and thus might be involved in HHV-6B-induced cell-cycle arrest.Virology 03/2014; s 452–453:254–263. DOI:10.1016/j.virol.2014.01.028 · 3.28 Impact Factor
Article: Higher incidence of Epstein–Barr virus-induced lymphocyte transformation in multiple sclerosis[Show abstract] [Hide abstract]
ABSTRACT: Objectives Epstein–Barr virus (EBV) infection is associated with multiple sclerosis (MS), and EBV may transform lymphoblastoid cell lines more frequently in MS patients than controls, but it is not clear whether this reflects a higher viral load or an enhanced ability to reactivate EBV.Material and methodsMS patients and controls were examined for their B-cell subsets and during 16 weeks for spontaneous lymphocyte transforming events.ResultsMS patients had normal distribution of B-cell subsets, but a significantly higher incidence of B-cell transforming events, which occurred with kinetics similar to controls.Conclusions The higher incidence suggests an increased frequency of latent EBV-infected B cells in MS.Acta Neurologica Scandinavica 03/2014; 130(2). DOI:10.1111/ane.12249 · 2.44 Impact Factor
Article: Human herpesvirus-6B protein U19 contains a p53 BOX I homology motif for HDM2 binding and p53 stabilization[Show abstract] [Hide abstract]
ABSTRACT: In order to establish a successful infection, it is of crucial importance for invading viruses to alter the activities of the regulatory protein p53. Beta-herpesviruses stabilize p53 and likely direct its activities towards generation of a replication-friendly environment. We here study the mechanisms behind HHV-6B-induced stabilization and inactivation of p53. Stable transgene expression of the HHV-6B protein U19 was sufficient to achieve upregulation of p53. U19 bound directly to the p53-regulating protein HDM2 in vitro, co-precipitated together with HDM2 in lysates, and co-localized with HDM2 in the nucleus when overexpressed. U19 contained a sequence with a putative p53 BOX I-motif for HDM2 binding. Mutation of the two key amino acids within this motif was sufficient to inhibit all the described U19 functions. Our study provides further insight into p53-modulating strategies used by herpesviruses and elucidates a mechanism used by HHV-6B to circumvent the antiviral response.Virology 01/2014; 448C:33-42. DOI:10.1016/j.virol.2013.10.002 · 3.28 Impact Factor
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ABSTRACT: Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.Archives of Virology 11/2013; 159(5). DOI:10.1007/s00705-013-1902-5 · 2.28 Impact Factor
Article: The B1-cell subpopulation is diminished in patients with relapsing–remitting multiple sclerosis[Show abstract] [Hide abstract]
ABSTRACT: B cell subsets in newly diagnosed untreated, relapsing-remitting multiple sclerosis (MS) patients were examined. The fraction of CD20(+) B cells was significantly increased in MS. Among subsets of B cells, MS patients had increased frequency of naïve cells, but reduced frequency of memory and B1 cells. The frequencies of B1 cells were inversely correlated with the time since last attack. B1 cells resembled the phenotype of either lymphocytes (CD11b(-) B1 cells) or monocytes (CD11b(+) B1 cells) and a small fraction of cells was CD3(+)CD20(+) by confocal microscopy.Journal of neuroimmunology 07/2013; 262(1-2). DOI:10.1016/j.jneuroim.2013.06.002 · 2.79 Impact Factor
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ABSTRACT: Most of the human herpesviruses can be found in semen, although the reported prevalence varies considerably between individual studies. The frequent presence of herpesvirus in semen raises the question whether sexual transmission of the virus could have an impact on human reproduction. Only few studies have associated seminal shedding of herpesviruses with impaired sperm quality, reduced fertility, or reduced chances of pregnancy, whereas most studies fail to find an association. Taken together, no firm evidence is so far linking the presence of herpesviruses in semen to impaired human reproduction.Virology Journal 07/2013; 10(1):226. DOI:10.1186/1743-422X-10-226 · 2.09 Impact Factor
Article: Synergy between Vitamin D3 and Toll-Like Receptor Agonists Regulates Human Dendritic Cell Response during Maturation[Show abstract] [Hide abstract]
ABSTRACT: Human dendritic cells (DC) can be differentiated from blood monocytes in the presence of GM-CSF and IL-4 and matured by lipopolysaccharide (LPS). Vitamin D3 inhibits the maturation of human DC measured by changes in surface expression of HLA-DR, CD14, CD40, CD80, CD83, and CD86. We here examine the function of vitamin D3 during DC maturation. One of the earliest changes to LPS-induced maturation was an increase in CD83 expression. Vitamin D3 inhibited the increase in expression of HLA-DR, CD40, CD80, CD83, and CD86 and the decrease in expression of CD14, which was paralleled morphologically by vitamin D3-induced inhibition of dendritic cell differentiation. Vitamin D3 acted in synergy with the TLR agonists LPS and peptidoglycan (PGN) in inducing IL-6, IL-8, and IL-10, whereas vitamin D3 completely inhibited LPS-induced secretion of IL-12. The synergy occurred at concentrations where neither vitamin D3 nor the TLR agonists alone induced measurable cytokine secretion. Both LPS and PGN enhanced the level of the vitamin D3 receptor (VDR). Taken together, these data demonstrated that vitamin D3 and TLR agonists acted in synergy to alter secretion of cytokines from human DC in a direction that may provide an anti-inflammatory environment.Clinical and Developmental Immunology 04/2013; 2013(10):807971. DOI:10.1155/2013/807971 · 2.93 Impact Factor
Article: Inhibition of p53-Dependent, but Not p53-Independent, Cell Death by U19 Protein from Human Herpesvirus 6B[Show abstract] [Hide abstract]
ABSTRACT: Infection with human herpesvirus (HHV)-6B alters cell cycle progression and stabilizes tumor suppressor protein p53. In this study, we have analyzed the activity of p53 after stimulation with p53-dependent and -independent DNA damaging agents during HHV-6B infection. Microarray analysis, Western blotting and confocal microscopy demonstrated that HHV-6B-infected cells were resistant to p53-dependent arrest and cell death after γ irradiation in both permissive and non-permissive cell lines. In contrast, HHV-6B-infected cells died normally through p53-independet DNA damage induced by UV radiation. Moreover, we identified a viral protein involved in inhibition of p53 during HHV-6B-infection. The protein product from the U19 ORF was able to inhibit p53-dependent signaling following γ irradiation in a manner similar to that observed during infection. Similar to HHV-6B infection, overexpression of U19 failed to rescue the cells from p53-independent death induced by UV radiation. Hence, infection with HHV-6B specifically blocks DNA damage-induced cell death associated with p53 without inhibiting the p53-independent cell death response. This block in p53 function can in part be ascribed to the activities of the viral U19 protein.PLoS ONE 03/2013; 8(3):e59223. DOI:10.1371/journal.pone.0059223 · 3.53 Impact Factor
Article: No increased sperm DNA fragmentation index in semen containing human papillomavirus or herpesvirus[Show abstract] [Hide abstract]
ABSTRACT: It remains unknown whether human papillomaviruses (HPVs) or human herpesviruses (HHVs) in semen affect sperm DNA integrity. We investigated whether the presence of these viruses in semen was associated with an elevated sperm DNA fragmentation index. Semen from 76 sperm donors was examined by a PCR-based hybridization array that identifies all HHVs and 35 of the most common HPVs. Sperm DNA integrity was determined by the sperm chromatin structure assay. HPVs or HHVs, or both, were found in 57% of semen samples; however, sperm DNA fragmentation index was not increased in semen containing these viruses.Andrology 02/2013; 1(3). DOI:10.1111/j.2047-2927.2013.00067.x · 3.37 Impact Factor
Article: Human Herpesvirus-6A/B Binds to Spermatozoa Acrosome and Is the Most Prevalent Herpesvirus in Semen from Sperm Donors[Show abstract] [Hide abstract]
ABSTRACT: An analysis of all known human herpesviruses has not previously been reported on sperm from normal donors. Using an array-based detection method, we determined the cross-sectional frequency of human herpesviruses in semen from 198 Danish sperm donors. Fifty-five of the donors had at least one ejaculate that was positive for one or more human herpesvirus. Of these 27.3% (n = 15) had a double herpesvirus infection. If corrected for the presence of multiple ejaculates from some donors, the adjusted frequency of herpesviruses in semen was 27.2% with HSV-1 in 0.4%; HSV-2 in 0.1%; EBV in 6.3%; HCMV in 2.7%; HHV-6A/B in 13.5%; HHV-7 in 4.2%, whereas none of the samples had detectable VZV or HHV-8. Subsequently, we examined longitudinally data on ejaculates from 11 herpesvirus-positive donors. Serial analyses revealed that a donor who tested positive for herpesvirus at one time point did not necessarily remain positive over time. For the most frequently found herpesvirus, HHV-6A/B, we examined its association with sperm. For HHV-6A/B PCR-positive semen samples, HHV-6A/B could be detected on the sperm by flow cytometry. Conversely, PCR-negative semen samples were negative by flow cytometry. HHV-6B was shown to associate with sperm within minutes in a concentration dependent manner. Confocal microscopy demonstrated that HHV-6B associated with the sperm head, but only to sperm with an intact acrosome. Taken together, our data suggest that HHV-6A/B could be transported to the uterus via binding to the sperm acrosome. Moreover, we find a 10 times higher frequency of HHV-7 in semen from healthy individuals than previously detected. Further research is required to determine the potential risk of using herpesvirus-positive donor semen. Longitudinally analyses of ejaculate series indicate that implementation of quarantine for a donor shown to shed a herpesvirus is not a tenable solution.PLoS ONE 11/2012; 7(11):e48810. DOI:10.1371/journal.pone.0048810 · 3.53 Impact Factor
Article: Epstein-Barr virus Peptide Presented by HLA-E is Predominantly Recognized by CD8 Cells in multiple Sclerosis Patients[Show abstract] [Hide abstract]
ABSTRACT: Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection, but impaired immune suppression may be part of the disease pathogenesis. CD8(+) T cells that are restricted by HLA-E exert an important immunoregulatory mechanism. To explore how EBV might interfere with immune regulation, we examined the expression of HLA-E and the frequency of CD8(+) cells recognizing HLA-E, presenting either an EBV peptide from the BZLF1 protein or a signal sequence peptide from HLA-A2, in relapsing remitting (MS-RR), primary progressive (MS-PP) MS patients, and healthy controls (HC). Treatment with IFN-α or EBV increased HLA-E expression on CD4(+) cells. However, only MS-PP had increased expression of HLA-E on resting CD4(+) cells when compared with HC (p<0.005). CD8(+) cells were divided into CD8(bright) and CD8(dim) cells by flow cytometry analyses. MS-RR had significantly fewer CD8(dim) cells than HC (p<0.003). Flow cytometry analyses were performed with HLA-E tetramers folded in the presence of the EBV or HLA-A2 peptide to identify HLA-E-interacting cells. MS-RR had increased frequency of CD8(bright) cells recognizing HLA-E/A2 (p = 0.006) and HLA-E/BZLF1 (p = 0.016). Conversely, MS-RR had fewer CD8(dim) cells that recognized HLA-E/BZLF1 (p = 0.001), but this could be attributed to the overall lower number of CD8(dim) cells in MS-RR. Whereas HLA-E/A2 was predominantly recognized by CD8(dim) cells, HLA-E/BZLF1 was predominantly recognized by CD8(bright) cells in MS-RR and MS-PP, but not in HC. As expected, HLA-E/A2 was also recognized by CD8-negative cells in a CD94-dependent manner, whereas HLA-E/BZLF1 was poorly recognized in all groups by CD8-negative cells. These data demonstrate that MS-RR patients have expanded their CD8(bright) cells recognizing HLA-E/BZLF1. Moreover, HLA-E/BZLF1 appears to be recognized by the immune system in a different manner than HLA-E/A2.PLoS ONE 09/2012; 7(9):e46120. DOI:10.1371/journal.pone.0046120 · 3.53 Impact Factor
Article: U20 Is Responsible for Human Herpesvirus 6B Inhibition of Tumor Necrosis Factor Receptor-Dependent Signaling and Apoptosis[Show abstract] [Hide abstract]
ABSTRACT: The immune system targets virus-infected cells by different means. One of the essential antiviral mechanisms is apoptosis induced by ligation of tumor necrosis factor receptor 1 (TNFR1). This receptor can be activated by tumor necrosis factor alpha (TNF-α), which upon binding to TNFR1 induces the assembly of first an inflammatory and later a proapoptotic signaling complex. Here, we report that infection by human herpesvirus 6B (HHV-6B) inhibited poly(ADP-ribose) polymerase (PARP) cleavage, caspase 3 and 8 activation, and IκBα Ser-32 phosphorylation downstream of TNFR1, indicating inhibition of both the inflammatory and apoptotic signaling pathways. We identified a hitherto uncharacterized viral protein, U20, as sufficient for mediating this inhibition. U20 was shown to locate to the cell membrane, and overexpression inhibited PARP cleavage, caspase 3 and 8 activation, IκBα Ser-32 phosphorylation, and NF-κB transcriptional activity. Moreover, small interfering RNA (siRNA) knockdown of U20 demonstrated that the protein is necessary for HHV-6B-mediated inhibition of TNFR signaling during infection. These results suggest an important novel function of U20 as a viral immune evasion protein during HHV-6B infection.Journal of Virology 08/2012; 86(21):11483-92. DOI:10.1128/JVI.00847-12 · 4.65 Impact Factor
Article: Altered frequency of T regulatory cells is associated with disability status in relapsing–remitting multiple sclerosis patients[Show abstract] [Hide abstract]
ABSTRACT: A perturbed immunoregulation may be part of the pathogenesis of relapsing-remitting multiple sclerosis (RRMS). In this study, we demonstrate a dichotomy within the frequency of Treg among newly diagnosed RRMS patients but not in healthy controls. A group of RRMS patients was characterized by a significantly lower percentage of Treg cells than that of their matched, healthy controls, and this was inversely correlated with their score on the expanded disability status scale (EDSS). Since the EDSS reflected severity of the last attack, this study demonstrates a correlation between low frequency of Treg and severity of clinical disease in RRMS.Journal of neuroimmunology 05/2012; 249(1-2):76-82. DOI:10.1016/j.jneuroim.2012.04.012 · 2.79 Impact Factor
Patent: Human herpes virus 6 and 7 u20 polypeptide and polynucleotides for use as a medicament or diagnosticumRef. No: WO/2011/095174 A1, Year: 08/2011
- [Show abstract] [Hide abstract]
ABSTRACT: Human papillomaviruses (HPV) may cause sexually transmitted disease. High-risk types of HPV are involved in the development of cervical cell dysplasia, whereas low-risk types may cause genital condyloma. Despite the association between HPV and cancer, donor sperm need not be tested for HPV according to European regulations. Consequently, the potential health risk of HPV transmission by donor bank sperm has not been elucidated, nor is it known how HPV is associated with sperm. The presence of 35 types of HPV was examined on DNA from semen samples of 188 Danish sperm donors using a sensitive HPV array. To examine whether HPV was associated with the sperm, in situ hybridization were performed with HPV-6, HPV-16 and -18, and HPV-31-specific probes. The prevalence of HPV-positive sperm donors was 16.0% and in 66.7% of these individuals high-risk types of HPV were detected. In 5.3% of sperm donors, two or more HPV types were detected. Among all identified HPV types, 61.9% were high-risk types. In situ hybridization experiments identified HPV genomes particularly protruding from the equatorial segment and the tail of the sperm. Semen samples from more than one in seven healthy Danish donors contain HPV, most of them of high-risk types binding to the equatorial segment of the sperm cell. Most HPV-positive sperm showed decreased staining with DAPI, indicative of reduced content of DNA. Our data demonstrate that oncogenic HPV types are frequent in men.PLoS ONE 03/2011; 6(3):e18095. DOI:10.1371/journal.pone.0018095 · 3.53 Impact Factor
Article: Human Herpesvirus 6B Induces Phenotypic Maturation Without IL-10 and IL-12p70 Production in Dendritic Cells[Show abstract] [Hide abstract]
ABSTRACT: Human herpesvirus 6B (HHV-6B) is the causative agent of the common childhood febrile illness, exanthema subitum. The virus is predominantly regarded as a T-cell tropic virus, although in reality it has the ability to infect a wide variety of cell types including monocytes, macrophages and dendritic cells (DC). Although DC are important immune regulators, the modulating effects of HHV-6B on DC are controversial. Here, we examine the phenotypic and functional consequences of HHV-6B infection of DC. The addition of HHV-6B to immature DC led to expression of the nuclear viral p41 protein and cell surface expression of the viral glycoprotein gp60/110 consistent with HHV-6B infection. Nevertheless, HHV-6B did not induce noticeable cytopathogenic effects or cell death in infected DC. Importantly, HHV-6B infection induced a partial phenotypic maturation of immature DC as demonstrated by a substantial increase in the expression of HLA-DR, CD86 and CD40, whereas only a minor increase in CD80 and CD83 was observed. This phenotypic maturation was, however, not followed by functional maturation, because HHV-6B infection did not induce IL-10 and IL-12p70 production in immature DC. However, infected DC were still able to react to bacteria-derived stimuli such as lipopolysaccaharide by an even more pronounced production of IL-10 and IL-12p70 when compared to that of uninfected DC.Scandinavian Journal of Immunology 06/2010; 71(6):431-9. DOI:10.1111/j.1365-3083.2010.02389.x · 1.88 Impact Factor
Article: Direct Repeat 6 from Human Herpesvirus-6B Encodes a Nuclear Protein that Forms a Complex with the Viral DNA Processivity Factor p41[Show abstract] [Hide abstract]
ABSTRACT: The SalI-L fragment from human herpesvirus 6A (HHV-6A) encodes a protein DR7 that has been reported to produce fibrosarcomas when injected into nude mice, to transform NIH3T3 cells, and to interact with and inhibit the function of p53. The homologous gene in HHV-6B is dr6. Since p53 is deregulated in both HHV-6A and -6B, we characterized the expression of dr6 mRNA and the localization of the translated protein during HHV-6B infection of HCT116 cells. Expression of mRNA from dr6 was inhibited by cycloheximide and partly by phosphonoacetic acid, a known characteristic of herpesvirus early/late genes. DR6 could be detected as a nuclear protein at 24 hpi and accumulated to high levels at 48 and 72 hpi. DR6 located in dots resembling viral replication compartments. Furthermore, a novel interaction between DR6 and the viral DNA processivity factor, p41, could be detected by confocal microscopy and by co-immunoprecipitation analysis. In contrast, DR6 and p53 were found at distinct subcellular locations. Together, our data imply a novel function of DR6 during HHV-6B replication.PLoS ONE 10/2009; 4(10):e7457. DOI:10.1371/journal.pone.0007457 · 3.53 Impact Factor
Article: Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigen[Show abstract] [Hide abstract]
ABSTRACT: The superantigen, encoded by the envelope gene (env) of the human endogenous retrovirus (HERV)-K18, may be involved in autoimmunity. Its expression is transactivated in B cells during infection with Epstein-Barr virus and in peripheral blood mononuclear cells (PBMCs) that are treated with IFN-alpha. We investigated whether HHV-6B infection was able to induce the expression of HERV-K18 env. The expression of HERV-K18 env gene was measured by real-time quantitative PCR in HHV-6B-infected PBMC. Infection of PBMCs with HHV-6B resulted in a rapid and dose-dependent induction of HERV-K18 env gene expression, predominantly in monocytes. Induction was dependent on the interaction of glycoprotein H with CD46, but did not require viral transcription or DNA synthesis. Cycloheximide inhibited both the induction and basal expression of HERV-K18 env, indicating that de novo synthesis of proteins was necessary. HHV-6B induced transcriptional activation of the endogenous superantigen HERV-K18 independently of virus replication, which may have consequences for the development of autoimmunity.Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology 07/2009; 46(1):15-9. DOI:10.1016/j.jcv.2009.05.015 · 3.47 Impact Factor
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ABSTRACT: Osteopontin (OPN) is a cytokine with multiple functions, including immune defense mechanisms against invading microorganisms. OPN-deficient mice are impaired in clearing intracellular pathogens, suggesting an important role of OPN during phagocytosis, but it remains to be defined how OPN may enhance this innate immune process. Here, we demonstrate that OPN binds to monocytes, but not resting T cells, NK cells, or B cells, and mediates chemoattraction of IL-1-activated human monocytes. Moreover, OPN binds in a specific manner to all known serotypes of the two bacterial species Streptococcus agalactiae and Staphylococcus aureus and opsonizes these bacteria for phagocytosis. We identify the integrin alpha(X)beta(2) (CD11c/CD18), which is highly expressed on the cell surface of monocytes, as a novel OPN receptor. To eliminate the contribution from other molecular interactions between the bacteria and the phagocyte, we show that OPN-coated synthetic beads are phagocytosed in an alpha(X)beta(2) integrin-dependent manner. The ligand recognition does not involve the RGD motif previously reported to support binding of OPN to integrins. Taken together, these data identify the alpha(X)beta(2) integrin as a novel OPN receptor that is required for OPN-mediated phagocytosis, thereby elucidating an important mechanism of an innate immune function of OPN.The Journal of Immunology 07/2009; 182(11):6943-50. DOI:10.4049/jimmunol.0900065 · 5.36 Impact Factor
Article: Toll-like receptor-induced granulocyte-macrophage colony-stimulating factor secretion is impaired in Crohn's disease by nucleotide oligomerization domain 2-dependent and -independent pathways[Show abstract] [Hide abstract]
ABSTRACT: Pattern recognition receptors (PRRs) are an integral part of the innate immune system and govern the early control of foreign microorganisms. Single nucleotide polymorphisms (SNPs) in the intracellular pattern recognition receptor nucleotide-binding oligomerization domain-containing protein (NOD2, nucleotide oligomerization domain 2) are associated with Crohn's disease (CD). We investigated the impact of NOD2 polymorphisms on cytokine secretion and proliferation of peripheral blood mononuclear cells (PBMCs) in response to Toll-like receptor (TLR) and NOD2 ligands. Based on NOD2 SNP analyses, 41 CD patients and 12 healthy controls were studied. PBMCs were stimulated with NOD2 and TLR ligands. After 18 h culture supernatants were measured using multiplex assays for the presence of human cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-1 beta and tumour necrosis factor (TNF)-alpha. In CD patients, TLR-induced GM-CSF secretion was impaired by both NOD2-dependent and -independent mechanisms. Moreover, TNF-alpha production was induced by a TLR-2 ligand, but a down-regulatory function by the NOD2 ligand, muramyl dipeptide, was impaired significantly in CD patients. Intracellular TLR ligands had minimal effect on GM-CSF, TNF-alpha and IL-1beta secretion. CD patients with NOD2 mutations were able to secrete TNF-alpha, but not GM-CSF, upon stimulation with NOD2 and TLR-7 ligands. CD patients have impaired GM-CSF secretion via NOD2-dependent and -independent pathways and display an impaired NOD2-dependent down-regulation of TNF-alpha secretion. The defect in GM-CSF secretion suggests a hitherto unknown role of NOD2 in the pathogenesis of CD and is consistent with the hypothesis that impaired GM-CSF secretion in part constitutes a NOD2-dependent disease risk factor.Clinical & Experimental Immunology 03/2009; 155(3):487-95. DOI:10.1111/j.1365-2249.2008.03850.x · 3.28 Impact Factor
Top Journals
Aarhus University
Aarhus, Central Jutland, Denmark
- • Department of Biomedicine
- • Department of Medical Microbiology and Immunology
Christian-Albrechts-Universität zu Kiel
Kiel, Schleswig-Holstein, Germany
- Institute of Clinical Molecular Biology
Harvard Medical School
Boston, Massachusetts, United States
- Department of Neurology
Dana-Farber Cancer Institute
Boston, MA, United States
- Division of Hematologic Malignancies
Brigham and Women's Hospital
Boston, Massachusetts, United States
- • Department of Medicine
- • Center for Neurologic Diseases


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Cambridge ROAR - Bollinger DinnerToday
Cambridge ROAR Presents Bollinger Dinner on Wednesday 8th July at 7pm-11pm
Cambridge ROAR - Wine & Cheese Festival09/07/2015
Cambridge ROAR Presents Wine & Cheese Festival on Thursday 9th July at 3pm - 9pm
Dine for Research09/07/2015
Charity Fundraising Dinner in aid of Spinal Research
Kizomba Dance Classes Every Thursday @ Lucy 1st, 211 CLAPHAM ROAD LONDON SW9 0QH09/07/2015
Every Thursday its the new weekly Kizomba classes @ Lucy 1st Bar its over the road from Stockwell underground station.
The Big Weekend10/07/2015
Cambridge's big summer festival held on Parker's Piece on Friday 10th July - Sunday 12th July
Cambridge ROAR - Tribute Night10/07/2015
Cambridge ROAR Presents Tribute Night on Friday 10th July at 7pm-12am
Cambridge Open Studios - weekends of July 201511/07/2015
The artists' network, which is one of the oldest Open Studios programmes in the country, has seen steady growth since it began over 50 years ago and represents a flourishing community of artists, craftspeople and designer-makers throughout Cambridgeshire. This July, 323 Cambridge Open Studio artists will be taking part in 219 different locations. There will be a wide range of artistic media to see, including painters, sculptors, jewellers, photographers, illustrators, furniture makers and many more. 112 new artists have joined for 2015, promising an even greater variety of art and events for the public to enjoy.
Babylon Summer Exhibition 2015: 'Our biggest open submission exhibition ever'11/07/2015
Babylon Summer Exhibition 2015: 'Our biggest open submission exhibition ever'
Cambridge ROAR - Hollywood Ball11/07/2015
Cambridge ROAR Presents Hollywood Ball on Saturday 11th July at 7pm-12am
Kizomba Dance Classes & Party in London the Saturday 11th Of July - Clube Vicio11/07/2015
London top Saturday night Kizomba party with the of the finest teacher teaching 3 levels of Kizomba classes. With 2 of the top DJ spinning the best of classic and fresh Kizomba, Semba & Ghetto Zouk


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It's no secret that we're always looking to give our customers the most choice when it comes to extending their Desk.com customer service environments. We haven't figured out how to make Desk.com wash windows –yet– but if you're looking for an integration to add telephony, chat, or even tutorials for your help center content, there's… Read more »
Desk.com the way you want it: Introducing Custom Agent Roles and Permissions
Our customers tell us all of the time how much they love Desk.com's intuitive workflow and UI. However, as they grow and become more successful they often come to the point where they want more freedom to define their own workflows and processes. We get it, our feelings aren't hurt. That's why we're thrilled to… Read more »
Communicating with customers via Auto-Acknowledgments
True or false – auto-acknowledgments are just meant to let your customer know that you've received their question? Don't answer, it's a leading question. :) Indeed, auto-acknowledgements are an extremely handy tool that lets your customers know that you've received and are working on their request. If you don't have one set up yet, see… Read more »
Need hlp ASAP? Jus txt w/ new Desk.com integration frm Teckst
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Product Updates: More customization, more flexibility, more security…read on.
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Military Sexual Assault Victims Testify Before Senate Panel
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You might be skeptical when we tell you the experience you will have with Dish Network satellite TV packages will be like no other you have had in the past simply because you have always been disappointed by the below standard services offered by the other vendors. The only way to experience the fact that we are indeed the real deal is to have a look and test some of the options we have for you. Included in our options is a wide variety of satellite TV packages that have been specially designed to meet you unique needs for home entertainment. We give you the ability to watch your favorite channels anywhere in the face of the world and on different platforms without necessarily restricting you to a television set. You can watch your favorite programs on your computer, tablet or smart phone. In this manner therefore, never again will you miss your favorite programs simply because you are not at home close to your television set.
The number of satellite TV providers in the market currently is simply mind boggling but we can say without any fear of contradiction that none of them offers you quality and reliability as the one you will find with Dish Network satellite TV packages. The following are some of the specific reasons why customers rave about Dish Network and why you too should join them-:
With the satellite TV services provided by Dish Network, you get an awesome chance to save lots of money not only with the monthly subscriptions but also with the many special promotions that are held regularly for the customers.
With Dish Network satellite TV packages, you get a chance to have high grade content that will give you the true experience you need form an awesome home entertainment system. With over 200 channels in high definition, you will never like options for entertainment from any package you choose from us. You will also love the quality of the sounds and the picture as we have invested in the state of the art technology to ensure that you get nothing but the absolute best.
Perhaps one of the greatest benefits of Dish Satellite TV services is the fact that you can carry it along with you wherever you. Gone are the days you had to miss your favorite programs simply because you are not at home at the time of the show.
Get the power to watch all your favorite programs on your smart phone, tablet or computer wherever you are.
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There is no doubting the fact that DISH Network has transformed the home entertainment scene. As a result, subscribers can now enjoy a huge choice of channels with crystal clear HD technology offered by satellite TV. Satellite TV offered by DISH has made it possible for viewers in remote areas to enjoy the same quality of programming offers to viewers in big cities. Dish Network has been at the forefront of providing Americans with quality programming. As the premier satellite TV provider, DISH Network offers its viewers the best deals on satellite TV, a feat that its competitors find difficult to match.
If you are looking for the best satellite TV deal, we invite you to explore Dish Network's broad packages where you are sure to find a deal that meets your entertainment needs. There are many reasons to make the switch and subscribe to Dish Network. Some of them include:
When you are looking for satellite TV deals, you need to subscribe to plans that offer you exactly what you want to watch. Dish Network is home to some of the most popular TV packages in America. You can choose a plan ranging from the Dish America package that includes all your favorite channels to the Americas Everything package with over 250 channels! Your choice will no doubt be inspired by your personal preferences, those of your family as well as how much you are willing to pay for your home entertainment. If you need a package with Latino content, check out the Dish Latino packages that offer a combination of Latino and English content. With some great packages starting from as low as $19.99 per month on a one-year subscription, Dish Network has you in mind.
One of the most impressive features of the Dish Network is that you can receive a crystal clear signal from any part of mainland United States. Although many urban viewers take it for granted that they have many options to choose from, the story is different for rural based subscribers. From Florida to Washington, New York to California and all points in between, Dish Network has you covered. So no matter where you live, in the city or the country, Dish Network can bring you the best content at the lowest price. As long as the provider sets up a satellite TV dish in your home, you will receive the best programming available on TV today. With the connection done, you have the freedom to choose your favorite plan from the Dish TV packages.
Many Americans love Dish Network due to the great features they offer including the most advanced DVR unit in the market. The Hopper whole home DVR brings some amazing functions to your living room. No more missing programs due to a busy schedule, just program the DVR and it will record any show or movie of your choice even if two or more of the shows are aired at the same time. In addition, Dish Satellite TV is the only provider in the market to offer you in excess of 200 HD channels. This means that when you choose your favorite Dish TV package, you get 200 HD channels free! No other provider can offer this quality of entertainment.