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A royal affairTired of home-cooked macher jhol bhaat or whatever's doing the rounds at the roadside joints? Well, Taj Bengal has a Marwari Food Fest that's on till 29 June and it takes you through the meandering lanes of Jodhpur and Marwar, dishing out the ... The Statesman, 1 week ago
19 images for marwaris
Why E-comm brands are becoming app-only?
By Alok Kejriwal I don't think of Marie Antoinette often. She is neither my VC, nor my contact in Google, nor a rich Marwari relative. If you don't know her, let me remind you that she was the Queen of France during the reign of her husband Louis ...Economic Times, 1 month ago E-commerce brands trying to cut losses by becoming app-only platforms: What are the pros & cons? Economic Times, 1 month ago
Actor Pooja Ghai shares her favourite Prawn Pulao recipe
Actress and Pooja Ghai is fond of eating and has a sweet tooth for Marwari sweets. In a candid conversation, Pooja reveals her food preferences and the recipe for her favourite dish too.. My earliest memory of food: Was as a child, eating Rajma ...Times of India, 3 weeks ago
Regular blood donation camp for govt. employees mooted
Comment · print · T T T+· T- Volunteers donate blood at a camp organised by Marwari Yuva Manch in association with AS Raja Volunteer Blood Bank in Visakhapatnam on Sunday.— PHOTO: K.R. DEEPAK Database of staff's blood group to be ...The Hindu, 3 weeks ago
Recipe for a mouth-watering Aam Ras
A popular dessert in Rajasthani, Marwari, Maharashtrian, Gujarati cuisines, especially during festivities, this mango pulp is a succulent sweetdish. Ingredients 2 mangoes - preferably Alphonso Sugar - as per taste 2 tbsp milk 1/4 tsp cardamom ...Times of India, 3 weeks ago
Stallions wait to gallop across seven seas
A ban on export halts the prance of Punjab's much-loved horses Nukra and email@example.com isn't just big cars and farms that jatts in Punjab like to flaunt.Stallions fuel ego as much.Times of India, 1 month ago
NextGen Marwaris are venturing beyond the family business
In the mid-19th century, they emerged from the arid Marwar region of the then Rajputana (now Rajasthan) and have been spreading across the Indian sub-continent, prompting the phrase Jahan na jaye bail-gaadi, wahan jaye Marwari (A Marwari will go to ...Hindu Business Line, 1 month ago
Gujarat cadre IPS gets first khaki couple
AHMEDABAD: IPS officers from the 2008 batch, Shobha (29), a Marwari from Latur and Pradeep (29), a Maratha from Aurangabad, fell in love when both were nursing dreams of becoming civil servants. They went to the same coaching class, cracked the ...Times of India, 1 month ago
Rajasthan CM Vasundhara Raje urges Bengal Marwaris to invest back home
Raje clarified that she was not here to take Marwari business back to Rajasthan but to urge them to make the state their second investment destination. KOLKATA: Rajasthan Chief Minister Vasundhara Raje today urged Marwaris of West Bengal to invest back home.Economic Times, 2 months ago Vasundhara Raje Urges Marwaris in West Bengal to Invest in Rajasthan NDTV, 2 months ago Rajasthan CM urges Bengal Marwaris to invest back home Business Standard, 2 months ago Rajasthan CM woos Mumbai businessmen, Sena fumes Times of India, 2 months ago
More from: , Bombay News.Net...and 5 other sources
A customized in-flight magazine for a Mauritius wedding by The Word Jockey!
For destination wedding in Mauritius of a Marwari couple, the families were flying the guests from Mumbai to Mauritius for the celebrations. This was another Big Fat Indian Wedding where the families wanted to raise the bar and create ...EventFAQs, 1 month ago
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Seoul, South Korea (CNN) -- Hundreds of Libyans stormed a South Korean-operated construction site near the Libyan capital Tripoli on Monday, wounding 17 and causing a stand-off between police and rioters, the South Korean Foreign Ministry said.
About 500 rioters raided the site 30 kilometers (18 miles) from Tripoli, the ministry said.
Of the 1,600 workers at the site, two Bangladeshi workers suffered serious wounds after they were stabbed and 15 other employees were hurt, the ministry said.
The foreign ministry said it will dispatch an emergency team to the site as soon as possible. The government has put in place an emergency evacuation plan for South Koreans to take shelter at designated locations if violence continues to break out across the country.

subset: commoncrawl


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Josh Phegley is the new Yasiel Puig
Jul 11, 2013, 7:10 PM EDT
Puigmania is over. It's old news. Could there be any better illustration than the fact that Freddie Freeman beat out Yasiel in a popularity contest this week?
It's OK, though. White Sox catcher Josh Phegley is the new big thing. He hit a grand slam Thursday in the White Sox's 6-3 win over the Tigers, giving him three homers in his first five games.
The 25-year-old Phegley is the 29th player in major league history to hit three homers in his first five games. Only Mike Jacobs and Puig have managed four. Other recent players to hit three include Manny Machado, Yoenis Cespedes, Will Middlebrooks and Yasmani Grandal.
Phegley's eight RBI through five games is tied for the 10th highest total in big league history. Jack Merson, Danny Espinosa and Puig had 10 RBI through five games. Hall of Famer Paul Molitor is among the players with nine.
A 2009 supplemental first-round pick out of Indiana, Phegley took a big step forward by hitting .316/.368/.597 with 15 homers in 231 at-bats for Triple-A Charlotte prior to his callup last week. He hit just .266/.306/.373 with six homers in 394 at-bats last year for the same team. While this year may prove to be something of a fluke for him offensively, he has overtaken Tyler Flowers in the White Sox's plans, and he's probably going to be the team's primary catcher going forward.
Now if only Salvador Perez will back out so we can get him on the All-Star team where he belongs.
- tfbuckfutter - Jul 11, 2013 at 7:29 PM
The weird ginger kid from Diary of a Wimpy Kid?
(Yeah, I know that movie….s'what?)
- necrondi - Jul 12, 2013 at 12:37 PM
He's not ginger. Once, again you prove to be one of the most daft posters in internet history.
- qcubed3 - Jul 11, 2013 at 7:35 PM
Thank you Josh for the only good news the ChiSox will have all season.
- proudlycanadian - Jul 11, 2013 at 7:44 PM
Alas, it is too late to vote for him to be an All Star.
- 11thstreetmafia - Jul 11, 2013 at 9:15 PM
Phuckin' Phegley.
- drewsylvania - Jul 11, 2013 at 9:37 PM
He won't get the hype, because his name is reminiscent of phlegm.
- scottychicago - Jul 11, 2013 at 11:15 PM
I'm just going to call him Phegatron.
- shapht - Jul 12, 2013 at 7:34 AM
Phegley's numbers are perhaps a bit phlukey this year, but don't forget he's spent much of his pro career working to overcome an autoimmune disorder called ITP, which he was diagnosed with shortly after being drafted. Instead of being a fluke, I think there's a better chance his health is allowing him to reclaim the tools that made him second in the country (to some guy named Posey) in batting average as a soph at Indiana, and an eventual first-round pick. There's a good chance this guy can be a mainstay for years to come.
The Charlotte Observer did a great piece on him recently: http://www.charlotteobserver.com/2013/07/02/4144588/knights-catcher-overcomes-struggles.html
- skinsfanwill - Jul 12, 2013 at 9:01 AM
Are you really friggin serious? This kid is batting .200 and has never had more than 1 hit in a game. He only has 4 hits, 3 of which happen to be home runs. You must be leading the Adam Dunn all -star campaign or something. You have the nerve to compare this kids start with Puig. Gimme a friggin break. There is no comparison. He's so great he is still in the free agent pool in my fantasy league.
- stlouis1baseball - Jul 12, 2013 at 12:41 PM
Easy Skins. Deep breathes. Inhale…exhale. Count to ten. Better?
- delsj - Jul 12, 2013 at 10:10 AM
Craig missed a perfect troll opportunity here letting Matthew post this. If this kid comes in and lights up the Phils this weekend and the Sox steal any more than one game, it will be a long All-Star break in Philly sub-500.
- stlouis1baseball - Jul 12, 2013 at 12:59 PM
Let's give up for the Homeboy from Terre Haute North!
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Miami Says Art-2 Raises the Curtain on Art Basel Week
On day one of Art Basel week, Miami's arts leaders gathered at the Mayfair Hotel for the opening reception of "Miami Says Art-2" to celebrate the cultural trailblazers who helped transform this city into a global art destination. The exhibition reprises visionary artist Martin Kreloff's groundbreaking 1976 show, where champions of the arts looked into his camera and proclaimed "ART!"
Kreloff brought together a stellar group of more than 100 of Miami's museum and gallery directors, performing arts and cultural leaders (alongside many from his original 1976 "Miami Says Art" cast) to once again exclaim "ART!" into his camera during Art Basel last year, so that he could prepare a time capsule exhibition. The photos were kept under lock-and-key all year long until this year's opening. The art was transformed into a wall of new portraits by Kreloff alongside his new collaboration with Miami artist Gustavo Oviedo, a black box installation of video and sound art that blended together to create a cultural time capsule showcasing Miami's rise to fame as one of the world's leading art destinations.
"Miami Says Art-2 has been an amazing homecoming for me," said Martin Kreloff. "I am thrilled to pay tribute to the arts leaders that make Miami such a cultural paradise." The exhibition was selected by national and international media as one of the highlights of this year's Art Basel week in Miami, and drew Miami's top cultural and arts leaders.
"We're proud to kick off Art Basel week as it always should, by honoring the cultural champions so pivotal to Miami's arts evolution," said Axel Gasser, General Manager of The Mayfair Hotel and Spa Miami. "The Mayfair Hotel experience is like staying within a living, breathing work of art - a true art hotel featuring unparalleled design, architecture, handcrafted details and artistic elements. Miami Says Art-2 also launches the Mayfair's 30th anniversary yearlong celebrations, which will be called "Miami Vices" to showcase the hotel's rich history of elegance, style and lots of Miami-style fun."
About the Artist Martin Kreloff:
Martin Kreloff's work is held by the New York Museum of Modern Art and dozens of other prestigious galleries, museums and corporate collections across America. Born in Brooklyn, Kreloff started painting when he was only 12 and began studying formally at the Brooklyn Museum, continuing on at the famed Parsons School of Design. He garnered a BFA and an MFA at the University of Miami. Many of his paintings found their way into the personal collections of some of the nation's most accomplished celebrities including Cary Grant, Joan Crawford, Ann Miller, Esther Williams and Gloria Vanderbilt. With more than 25 solo shows to his credit, Kreloff has been commissioned to create artwork for Warner Brothers; Universal Pictures; Royal Caribbean Cruise Lines; Nielsen/National Research Group; Harley Davidson; Bloomingdale's; The American Civil Liberties Union; The Miami Herald; and The San Francisco Chronicle. http://martinkreloff.com/
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IMAGES | X360, PS3, PC Thursday, August 16, 2012 | 5:13 PM
GC: More Fifa screens
All comments
Posted by RazorbackVIBut that would be a yellow card.
haha, shame they couldn't animate him taking his shirt off.
haha, shame they couldn't animate him taking his shirt off.
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DO YOU HAVE EXPERIENCE WITH INTRATYMPANIC DEXAMETHASONE INJECTIONS, OR A QUESTION? Please post a comment below as I'd love to hear your thoughts.
In 1861 a man named Prosper Ménière put his name to a disease with no known cause or cures. After 150 years of no real answers from the medical community, this blog is one woman's exploration of Meniere's Disease; why she has it, how she hopes to get rid of it, and in the meantime, how she manages to live with it & move forward.
Sunday, 22 April 2012
MORE on Intratympanic Dexamethasone Injections to Reduce Menieres Vertigo Attacks
DO YOU HAVE EXPERIENCE WITH INTRATYMPANIC DEXAMETHASONE INJECTIONS, OR A QUESTION? Please post a comment below as I'd love to hear your thoughts.
4 comments:
- Anonymous28 February 2013 at 03:29
When should the fullness disappear?ReplyDelete
- Anonymous10 January 2014 at 06:05
My wife has had meniere's since 2008,in 2013 read your article and found ad Doctor who was willing to give my wife the dexamethesone injection. He gave here 2 shots 2weeks apart,the vertigo immediately stopped.For 6 months she was almost symptom free.Now 6 months later the vertigo has returned we went back to the doctor but he was hesitant to give here another shot,and he wanted here to take oral prednisone,she had tried this before but made the symptoms worse.Are more shots sometime needed.Thanks so much for your help.ReplyDelete
- Anonymous12 December 2014 at 17:19
I recommend seeing a surgeon who wears gloves during procedures.ReplyDelete
- Anonymous16 April 2015 at 19:40
does this procedure cause any destruction of the balance system in the ear being treated?ReplyDelete
is it recommended for persons with Bilateral Menieres?


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That is one incredible looking tower, and with a great backstory.
Simply amazing. I like how the new tower compliments Tokyo Disney Sea and helps fill out the NY section of the park. I also can't wait for the review of the OTHER new Tower under construction in Paris. I think we are about to find out what a difference budget really makes with a single ride technology.
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That ride video is excellent. I love the drop sequence itself; hearing everyone scream made me smile like being on the ride itself!
Nice effects. It's nice to see that the imagineers have what it takes to accomplish all that.
That pre-show is amazing. It would be great to have something like the stained glass effect at DCA or MGM. I really want to take a trip to Tokyo, anyone willing to help me pay for it? I can understand the cost after reading Joe's post. The safety upgrades probably cost alot as well as using the Japanese manufacturer. I really like the lightning effect ont he outside too. I wonder if they can add that to the other Towers?
Im having no luck getting this video. (web site crashing?)
Anyone have another link?
It certainly beats DCA's version. I am not sure if I prefer it to DMGMS version. But the preshow is wonderful. I never felt that the Twilight Zone connection was needed in the ride. A duel dimension concept has been in Sci Fi books for years. Twilight Zone is also an anchient show that anyone under 35 would not know about.
My hat's off to the Japanese. They certainly out did Disney!
Jiminy Cricket Fan
Love Disneyland and Walt Disney World!
As it's all written in japanese on the site, here is how to find them! After the intro, when you arrive on the home page, you'll find a small "copyright disney" on the right, in the lower part of the page. Counting from the right , at the same level than this copyright, click on the 3rd japanese link . It will lead you to the page with the choice of the two videos. Don't miss them, they're great, and one of the movie last at least 5 minutes!
yeah that effect is great .. but somehow reminds me of the queue in IOA Dueling DragonsThat pre-show is amazing. It would be great to have something like the stained glass effect at DCA or MGM.
I'd love to see how the Idol effect was done
yea i want to know how that idol effect workes too! I remember an initial storyboard/ride script say that the stained glass window would break and the guests would be able to walk through it to the loading area...but still! that effect rocked!
For me, Tomorrow is everyday...wait...what?
SUPPORT THE CMs
Wow! This really puts DCA's and the Studios' Tower of Terrors to shame!!!!


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Having distinctive religious traditions matters because each tradition expresses a distinctive identity, philosophy, tradition, set of values, mythology, and community identity. These traditions are ways of being in the world. They are collective projects which explore the question of "How shall we live a good life?" (and what do we mean by 'a good life') in very different ways. They each have their own rich collection of source texts and rituals which try to answer that basic question, along with many of the other great existential questions, such as "Why are we here?" [Read more...]
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LOVE the curtain on the dresser! Takes up less space than opened doors & certainly looks more elegant. I wonder if I could take off our dresser doors... #dorm
Swirl Vinyl Decal size LARGE - Swirl, Swirl Decal, Swirl Sticker, Swirl Wall Art, Flourish, Flourish wall art, Flourish Decal. $34.95, via Etsy.
Painted tree silhouettes on wall fit with hooks for hats & coats - beautiful and it doesn´t take much space
Best non-permanent way to decorate - I have these wall art stickers all over my apartment. (whatisblik.com)
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Besides the nice chair- the framed prints bring color to the bleak dorm rooms that end up catching scotch-taped paper-art.
20 Dorm Rooms You Wish Were Yours Need some dorm room ideas? Well, thankfully, some people go all out so take from their experience.
This definitely might inspire a color palette that I'm leaning towards for my dorm.. Digging the shades of mustard yellow and mint blue/sea green/whatever and pops of pink. And normally I hate pink but those shades are bearable. ALSO IF I CAN FIT A POUF IN MY DORM I WILL BE THE COOLEST.


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14th February 2013
Alice Arnold: Homophobia is still rife, just look at Twitter 4
5:36 PM — Speaking to the Public Bills Committee on Thursday to give evidence in favour of equal marriage, Alice Arnold, former BBC broadcaster said she though homophobia would be reduced if same-sex couples could marry.
Catholic Labour MP criticises Archbishop of Southwark for suggesting Catholics will leave Church over equal marriage 10
4:57 PM — The Catholic Archbishop of Southwark Peter Smith has been criticised for claiming that most Catholics who support equal marriage would be prepared to leave the Church over the issue
Video: Green MP Caroline Lucas comes @Out4Marriage and trans inclusion at Parliament 1
2:23 PM — After casting her vote in favour of equal marriage at last Tuesday's vote on it in the House of Commons, Green MP Caroline Lucas gave an impassioned speech to LGBT rights advocates.
Comment: Happy Valentine's Day from @Out4Marriage! #WillYouMarryMe m'Lord? 8
1:04 PM — James-J Walsh, Campaigns Director for Out4Marriage reflects on giving evidence at the Public Bills Committee for equal marriage, and details what you can do next in the last stages of the move towards marriage equality.
Lord Pannick: Forcing churches to perform same-sex weddings would be 'more difficult than parting the Red Sea' 17
12:41 PM — A top Blackstone lawyer and peer has given evidence to the Public Bill Committee scrutinising the same-sex marriage bill to the effect that succeeding in a court case against a church that refuses to opt-in to same-sex weddings would be legally impossible.
13th February 2013
Thailand: Public hearings on civil unions begin 6
7:01 PM — A series of public hearings in Thailand to discuss the possibility of establishing civil partnerships for gay couples has been taking place in Bangkok.
US: Mayor of Atlanta admits that he was 'wrong' to oppose equal marriage in the past 4
4:29 PM — The Mayor of Atlanta, who recently announced he had changed his stance to support equal marriage, has said he feels he "was wrong" to have opposed equal marriage in the past, in favour of civil unions.
Illinois Senate prepares for Valentine's Day equal marriage vote 1
3:56 PM — The Illinois Senate will vote tomorrow - Valentine's Day - on whether to legalise same-sex marriage.
Comment: Reflections on speaking out for equal marriage before a committee of MPs tasked with changing the law 27
3:11 PM — PinkNews and Out4Marriage founder Benjamin Cohen, reflects on giving evidence at the Public Bills Committee for equal marriage.
Tory MP Henry Smith: MPs who abstained in the same-sex marriage vote are 'chickens' 31
2:41 PM — Conservative MP Henry Smith has described MPs who abstained in last week's vote of the Marriage (Same Sex Couples) Bill as "chickens".
UK: Conservative councillor Mormon brothers leave party over equal marriage 56
1:36 PM — Two Mormon councillors in Warwickshire, who are also brothers, have quit the Conservative Party over its support for same-sex marriage.
Associated Press updates its style guide on whether to call married gay couples 'husband' or 'wife' 24
10:49 AM — Same-sex couples in marriages or civil partnerships should not be classified as "husband" and "wife" according to the Associated Press' style guide – unless they already use the terms.
12th February 2013
Tory MP David Burrowes: PinkNews is 'fomenting abuse' against equal marriage opponents 92
7:37 PM — Tory MP David Burrows has accused PinkNews of "fomenting hostility" against the opponents of equal marriage.
Michael Gove seeks to reassure Tory equal marriage critics in front of committee 13
7:20 PM — Education Secretary Michael Gove has again sought to reassure critical Conservative MPs that the government's same-sex marriage bill for England and Wales poses no threat to teachers who disagree with the reform.
Coalition for Marriage: 'The equal marriage bill is causing a shortage of teachers' 59
6:01 PM — Whilst giving evidence to the The Public Bill Committee of the House of Commons around the equal marriage bill, the Coalition for Marriage blamed potential marriage equality for a shortage of teachers.
Stonewall boss: Civil partnerships haven't reduced homophobia so we need equal marriage 33
5:19 PM — The chief executive of Stonewall says his charity's support for equal marriage stems from the failure of civil partnership legalisation to reduce homophobia in British society.
French National Assembly approves equal marriage bill 12
4:20 PM — France took a step closer to legalising equal marriage and adoptions for same sex couples, as its National Assembly approved a bill to do so, during its second reading today.
France: National Assembly expected to pass equal marriage bill 2
3:03 PM — France could take another step closer to legalising marriage equality, as its National Assembly is set to vote on a measure to legalise it this afternoon.
UK: Same-sex marriage bill to face scrutiny from Commons committee by MPs with mixed views on equality 24
1:58 PM — The Public Bill Committee of the House of Commons – made up of MPs who both have spoken against and in favour of LGBT equality – begins the task of scrutinising the government's equal marriage bill this afternoon.
11th February 2013
US: Colorado Senate prepares for final vote on civil unions 2
5:25 PM — The Senate House in the US state of Colorado is preparing for what could be its final vote on a measure to introduce civil unions for same-sex couples.


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I Arrived At The White House… And Didn't Go Inside.
If you were invited into the White House, would you automatically say Yes? Why? ...Read more ›
If you were invited into the White House, would you automatically say Yes? Why? ...Read more ›
Sometimes wise action means blocking the doors to a police weapons expo. Support Buddhists learning dharma wisdom and nonviolent action tools for social justice. ...Read more ›
Buddhists, Native Americans, and white environmentalists unite against fracking in California. ...Read more ›
Buddhist Peace Fellowship used the peacefulness of our sitting meditation posture to interrupt the flow of foot traffic at the downtown Oakland Marriott Hotel, which was hosting Urban Shield, a weapons expo and militarized training site for police. The Marriott was not happy with our peaceful protest, and immediately called the cops to remove us. Still, we continued sitting. ...Read more ›
I'm sitting in my home in Oakland, California, meditating as police helicopters fly overhead. I am not at the protests demanding justice for Mike Brown, even though I live only a few minutes from where they are taking place. ...Read more ›
Don't miss Episode #3 of Danny Fisher's new Buddhist podcast series, "Off the Cushion!" Danny asks BPF's Co-Directors Dawn Haney and Katie Loncke about issues of structural racism in Buddhist communities, and the militarization of police forces in the United States ...Read more ›
Buddhist Peace Fellowship and allies decided to stage a group meditation blockading the doors of a Marriott Hotel in Oakland, California. The reason? Police violence and institutionalized hatred. ...Read more ›
Dispatch from the Front Lines BPFer Stephanie Thomas tells us what it's like to get arrested for the first time in Houston while resisting the Keystone XL Pipeline On September 16th, I was arrested while participating in a peaceful demonstration against TransCanada Corporation. This was an event planned by Credo Action for their Pledge of Resistance: the goal of the action was to send a message to President ...Read more ›
With our online connections thriving, BPFers are calling for a face-to-face meet-up. Pulling off the first Buddhist Peace Fellowship gathering since 2006 won't be easy. Can you help us build the momentum to peacefully confront war, prisons, climate change, and more? Come watch our brand-new video and see what you can do to support The System Stinks 2014 & a BPF gathering! ...Read more ›
As the fight heats up this summer over the proposed Keystone XL pipeline, are we prepared to stand up and say no to what's been called "game over" for earth's climate? BPF's legacy, and our future, is one of Buddhists putting our bodies on the line, staying cool in the hot pressure cooker of direct action, drawing on spiritual wisdom and the depth of our practice. Through our connections together as a fello ...Read more ›
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Antimitotic effects of usnic acid on different biological systems
- M. Cardarelli,
- G. Serino,
- L. Campanella,
- P. Ercole,
- F. De Cicco Nardone,
- O. Alesiani,
- F. Rossiello
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Usnic acid is a biosynthesis product char acteristic of several epiphytic lichens such as Evernia, Cladonia and Parmelia. Usnic acid has several interesting biological properties. It is an antibiotic and it also seems to exert an antimitotic action. It has even been postulated that usnic acid can play a role as an environmental indicator, since its concentration varies according to the presence of toxic agents. A series of tests have been run on different biological systems such as fungi, yeasts, plant cells and neoplastic human cell cultures in order to make a general evaluation of the properties of usnic acid and to highlight any analogy between its effects on phylogenetically distant organisms. The results obtained confirm some of the already known properties of usnic acid and identify concentration ranges that are active against cells from different organisms. Furthermore, at low concentrations, the acid displays a capacity to stimulate cell metabolism in some of the biological systems tested.
- Title
- Antimitotic effects of usnic acid on different biological systems
- Journal
Cellular and Molecular Life Sciences CMLS
Volume 53, Issue 8 , pp 667-672
- Cover Date
- 1997-09
- 10.1007/s000180050086
- Print ISSN
- Online ISSN
- 1420-9071
- Publisher
- Birkhäuser Verlag
- Additional Links
- Keywords
- Key words. Usnic acid; antimitotic and antimycotic properties; fungus; N. tabacum; yeast; tumour cell line; environmental indicator.
- Industry Sectors
- Authors
- M. Cardarelli (A1)
- G. Serino (A2)
- L. Campanella (A3)
- P. Ercole (A3)
- F. De Cicco Nardone (A4)
- O. Alesiani (A4)
- F. Rossiello (A4)
- Author Affiliations
- A1. Centro Acidi Nucleici, c/o Genetics and Molecular Biology Department, P.le Aldo Moro 5, I-00185 Rome (Italy), Fax +39 6 4440812, IT
- A2. Genetics and Molecular Biology Department "La Sapienza" University, P.le Aldo Moro 5, I-00185 Rome (Italy), IT
- A3. Chemistry Department "La Sapienza" University, P.le Aldo Moro 5, I-00185 Rome (Italy), IT
- A4. Gynecology and Obstetrics Institute, Polyclinic Gemelli, L.go A. Gemelli 8, I-00168 Rome (Italy), IT


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
27 year old woman | Marietta, GA, USA | Seeking men 24-31 within 5 miles
I'm just me! Always will be!
I am extremely unique,sometimes hard to understand yet very simple to pleas.I live my life for love and compassion.I could wright a story of my life and accomplishments and most still would think I am fiction.I take care of my father,a blind man,and my younger brother on top of working 40 hours a week.My family is absolutely everything to me and always will be! I am ready to grow something special with someone that has similar goals and family values,for family is everything,think about it. No matter who comes in and out of your life in the end who will ALWAYS be right there? I truly care for everyone and anyone! I never grew up having my mother around,it has always been my father.The only mother I know raised me old school;my grandma may she rest in peace. If it wasn't for my rough and unfortunate upbringing,I wouldn't be as fortunate as i am today! Everyone has a story and I am always ready to listen! I am unable to get out as much as I would like to explore the wonders of the gorgeous country of ours,I suppose I am just waiting to come across someone special to make those memories with!
Camping , Coffee and conversation , Dining out , Fishing/Hunting , Gardening/Landscaping , Hobbies and crafts , Movies/Videos , Museums and art , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing cards , Playing sports , Religion/Spiritual , Shopping/Antiques , Travel/Sightseeing , Volunteering , Watching sports , Wine tasting
Auto racing / Motorcross, Baseball, Dancing, Football, Hockey, Other types of exercise, Running, Walking / Hiking
I exercise 3-4 times per week.
I have Cats, Dogs
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'2" (157cms)
|5'10" (177cms) to 6'3" (190cms)
|Body type:
|About average, Athletic and toned, A few extra pounds
|No preference
|Dark brown
|No preference
|Yes, but trying to quit
|Occasionally, Daily, Yes, but trying to quit
|Social Drinker
|Social Drinker, Moderately
|Medical / Dental / Veterinary / Fitness
|Administrative / Secretarial, Artistic / Creative / Performance, Executive / Management, Financial / Accounting / Real Estate, Labor / Construction, Legal, Medical / Dental / Veterinary / Fitness, Political / Govt / Civil Service / Military, Sales / Marketing, Self-Employed / Entrepreneur, Technical / Science / Computers / Engineering, Travel / Hospitality / Transportation, Other profession, Law enforcement / Security / Military, Architecture / Interior design
|$35,001 to $50,000
|Less Than $25,000, $25,001 to $35,000, $35,001 to $50,000, $50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000, $150,001+
|I'll tell you later
|Never Married, Divorced
|Have kids:
|Yes, and they sometimes live at home, No, Yes, and they live at home
|Wants kids:
|Latino / Hispanic, White / Caucasian, Other
|Latino / Hispanic, Native American, Pacific Islander, White / Caucasian, Other
|Christian / Catholic
|Christian / Catholic, Spiritual but not religious, Christian / Other
|I'll tell you later
|English, French, Italian, Spanish, Other
|Some college
|High school, Some college, Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


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Articles tagged dj krush
15 Jun 2011 // 6:00 AM
If we are going to learn to grin and bear this year's enhanced, prolonged stormy activity, we need an equally stormy playlist to accompany the thunderstorms, tornadoes, hurricanes, and whatever other maladies Mother Nature might throw our way during this summer seasonREAD more
//Mixed media
Colette Carr "Static" (video) (Premiere) // Music
House of Blondes "First of July" (audio) (premiere) // Music
Digisaurus 'No More Room For Love' (EP stream) // Music
Eszter Balint 'Airless Midnight' (album stream) (premiere) // Music
//Pm Picks
PopMatters is on a short summer publishing break. We resume Monday, July 6th.
// Announcements
"PopMatters is on a short summer publishing break. We resume Monday, July 6th.READ the article


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Keg Stand Granny Shows LSU Tailgate Party How It's Done [VIDEOS]
They call her Miss Lamb, but she's really a party animal in the body of an 83 year old woman! Check out Keg Stand Granny at LSU Tailgate Party!
They call her Miss Lamb, but she's really a party animal in the body of an 83 year old woman! Check out Keg Stand Granny at LSU Tailgate Party!
From LSU's facebook page: LSU Police, with the assistance of multiple other Law Enforcement agencies, have made an arrest in the bomb threat directed toward the LSU campus.
Students were evacuated within an hour after the bomb threat was called in.
A bomb threat has been reported on the LSU Campus.
From LSUEOC: Please evacuate as calmy and quickly as possible.
The "Honey Badger", Tyrann Mathieu is no longer an LSU Tiger. Head Coach Les Miles said that Mathieu is being let go after again violating team rules. The coach did not give specific details.
Final approval needed for LSU to begin a planned expansion to Tiger Stadium was granted by a state financing panel Thursday. The plan will add new seats to the stadium's south end zone.
Of all the US athletes set to participate in the 2012 Summer Olympics in London, none have captured our hearts more so than Lolo (real name Lori) Jones. And why not?
Take the kids out to meet goats, chickens, hogs and more! The 4-H Livestock Show and Sale takes place this Friday and Saturday at Blackham Coliseum in Lafayette. The Livestock Show begins at 8:30 on Saturday, January 20th.
Bobby Hebert defended his question to Coach Les Miles about his decision not to play Jarrett Lee. Bobby told journalists and fans why he had to ask the one question that every fan wanted to ask. Listen to the Cajun Cannon explain that he's not goi
Bobby Hebert calls out les Miles over the 21 to 0 loss to Bama. Disrespectful or not?
I put together some of the comments following LSU's embarrassing debacle at the Superdome last night.


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Careers at IPR
Inform | Enrich | Engage
Work for a leader in public media! Iowa Public Radio, a nonprofit organization, and its network of stations licensed to Iowa's public universities, serves over 200,000 listeners in Iowa. True to our mission, IPR strives to enhance Iowan's civic and cultural connections.
Broadcast Operations Specialist - Located in Ames
For full consideration, please submit application by 5 pm Thursday, June 18.


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The bq2510x series of devices are highly integrated Li-Ion and Li-Pol linear chargers targeted at space-limited portable applications. The high input voltage range with input overvoltage protection supports low-cost unregulated adapters.
The bq2510x has a single power output that charges the battery. A system load can be placed in parallel with the battery as long as the average system load does not keep the battery from charging fully during the 10 hour safety timer.
The battery is charged in three phases: conditioning, constant current and constant voltage. In all charge phases, an internal control loop monitors the IC junction temperature and reduces the charge current if an internal temperature threshold is exceeded.
BQ25101H – 250-mA Single Cell Li-Ion Battery Charger, 1mA termination, 75nA Battery leakage – [Link]
The LTC2946 is a high or low side charge, power and energy monitor for DC supply rails in the 0V to 100V range. An integrated ±0.4% accurate, 12-bit ADC and external precision time base (crystal or clock) enables measurement accuracy better than ±0.6% for current and charge, and ±1% for power and energy. A ±5% accurate internal time base substitutes in the absence of an external one. All digital readings, including minimums and maximums of voltage, current and power, are stored in registers accessible by an I²C/SMBus interface. The part's wide operating range makes it ideal for monitoring board energy consumption in blade servers, telecom, solar and industrial equipment, and advanced mezzanine cards (AMC).
LTC2946 – Wide Range I2C Power, Charge and Energy Monitor – [Link]
by linear.com:
The LTC3350 is a supercapacitor charger and backup controller IC that includes all of the features necessary to provide a complete, standalone capacitor-based backup power solution. Many applications require reliable short-term uninterrupted power in the event of a main power failure. Examples include data backup for solid state drives (SSDs) and nonvolatile dual in-line memory modules (NVDIMMs), power fail alarms in medical and industrial applications, as well as a host of other "dying gasp" power fail indicators. The LTC3350 provides all PowerPath control, capacitor stack charging and balancing, and capacitor health monitoring to ensure that the backup system is capable of reliable operation.
LTC3350 – High Current Supercapacitor Backup Controller and System Monitor – [Link]
By Stephen Evanczuk
For circuits relying on lithium-ion cells, determining the amount of charge remaining in a cell requires specialized techniques that can complicate the design of energy-harvesting applications. Engineers can implement these techniques with MCUs and ADCs normally used in these applications, but at the cost of increased complexity. Instead, engineers can easily add this functionality to existing designs using dedicated "fuel-gauge" ICs available from manufacturers including Linear Technology, Maxim Integrated, STMicroelectronics, and Texas Instruments.
Determining the state of charge (SOC) in lithium-ion batteries is essential yet challenging due to the great variability in capacity not only across different cells, but also in the same cell. As a Li-ion cell ages, it loses its ability to store charge. Consequently, even if fully charged, an older cell would deliver usable voltage for a shorter period of time than a newer cell. With any Li-ion cell, SOC varies greatly depending on the temperature and discharge rate, resulting in a unique family of curves for any particular cell (Figure 1).
Fuel-Gauge ICs Simplify Li-Ion Cell Charge Monitoring – [Link]
biolitestove.com writes:
Forget the fuel. Our stoves cook your meals with nothing but the twigs you collect on your journey, eliminating the need for heavy, expensive, polluting petroleum gas. It's quick to light, fast to boil and clean to use.
Charge your gadgets. By converting heat from the fire into usable electricity, our stoves will recharge your phones, lights and other gadgets while you cook dinner.
Have fun. Like a campfire, you can sit around the CampStove and watch the flames dance as you roast marshmallows and tell stories with friends.
Product Details
- Powers all USB-chargeable devices including smartphones, LED lights, GPS and many others.
- Fast to boil.
- Lights quickly and easily.
- Burns sticks, pine cones, pellets and other biomass.
- Folds for easy packing.
- Packed size: 8.25 x 5″.
- Weight: 2 Lbs 1 oz / 935 gram
BioLite CampStove – Charge your gadgets in fire – [Link]
Scientists at the University of Washington (USA) have developed a new type of transistor that uses protons instead of electrons for charge transport. It is intended to simplify the interfacing of electronic circuitry to the brains of living organisms, since protons (positively charged hydrogen atoms) and ions are responsible for signal transport between nerve cells. Proton-based transistors are therefore better suited to controlling and monitoring processes in the brain.
The researches discovered that the natural biomaterial chitosan, obtained from squid pens and crab shells, is a good proton conductor. They then used it to fabricate a transistor that can generate proton pulses. The prototype device is a field-effect transistor with a source, gate and drain, but it operates with protons. [via]
Novel transistor uses protons for charge transport – [Link]
Photovoltaic polarizers enable devices to be powered by sunlight
New technology developed by researchers at the UCLA Henry Samueli School of Engineering and Applied Science could finally help solve the problem of smartphones or laptops running down when there is no access to an electrical outlet.
UCLA engineers have created a novel concept for harvesting and recycling energy for electronic devices — one that involves equipping these devices' LCD screens with built-in photovoltaic polarizers, allowing them to convert ambient light, sunlight and their own backlight into electricity. [via]
Phone LCDs charge … phone batteries! – [Link]


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Watch Major Crimes Season 3 Episode 1 online to see Rusty receive unexpected news.
|Watch Now
|Watch Now
|Watch Now
|YouTube Purchase
|Watch Now
|Google Play
|Watch Now
Episode Details
When a father and his two young children go missing and Sharon realizes Rusty is up to something but doesn't want to tell her.
- Show:
- Major Crimes
- Season:
- Major Crimes Season 3
- Episode Number:
- 1


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Alex McKinnon was on Victoria's Mornington Peninsula to capture the Couta Boats in the Gant Portsea Cup. Nigel Abbott continued his string of recent victories with his crew on board, Romy, as the breeze built, the sunshine started to disappear behind clouds and the equipment began to fail or get damaged in incidents on the course near Port Phillip Heads.
Greg Chisholm''s C1999 Rhapsody and Tim Phillips'' C17 Muriel on their way in to the top mark right off Portsea front beach - Gant Portsea Cup 2013
The tide was running out quite quickly and there was a fair amount of shipping movement in the adjacent South Channel, as the race got underway around an old school Olympic course.
C03 Darney 5752 - Gant Portsea Cup 2013
The pin end was very much favoured and Darney got away impressively, but for them, that was as good as it got, with a broken gaff later taking them straight off the track and home for an early beer.
A couple of individual recalls also meant to action was on from the word go and the judges too had lots to review as Division One and Two fleets began to separate over the long course and met at various turning marks along the way... Division Two Line Honours went to Trevor Martin's Joan.
First Work 5564 - Gant Portsea Cup 2013
Ultimately smiles won the day and by the looks of all the sailors back at the Sorrento clubhouse, a long and joyous season looks to be well underway. Well done to all the sailors and volunteers for being part of such a great event.
Details can be found at sscbc.com.au
Ship 5384 - Gant Portsea Cup 2013
C28 Wattle 5708 - Gant Portsea Cup 2013
C122 Swan 6433 - Gant Portsea Cup 2013
IMG 5519 - Gant Portsea Cup 2013
C2006 Zepher and C03 Darney 5817 - Gant Portsea Cup 2013
Start 5481 - Gant Portsea Cup 2013
C2003 Romy 6506 - Gant Portsea Cup 2013


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BakerHostetler Partner Alan Friel Talks Big Data and Data Collection
IP|Trend: It's Time to Get to Know the Federal Trade Commission
Polsinelli Podcast - Keep the Government out of Your Transaction: Practical Antitrust Tips for Mergers
Polsinelli Podcast - Public Policy Issues in 2013
Social Media Law Report - Who Owns Your LinkedIn Account, FTC Guidance on Social Ads, More...
$300 Million Dairy Settlement Will Bring Reform, Lawyer Says
Corporate Law Report: U.S. Manufacturing, Social Media, Online Endorsements, Hart Scott Rodino, More
Following the Texas Attorney General's objection to the sale of RadioShack Corporation's consumer data as an asset in its bankruptcy, 37 other state attorneys general and a large number of other consumer protection entities...more
In This Issue:
- Second Circuit Rules Patriot Act Does Not Authorize Bulk Metadata Collection; Congress Reconsiders Certain Patriot Act Authorities
- SEC Issues Cybersecurity Guidance for Investment Companies...more
On April 10, 2015, RadioShack, and certain affiliated debtor entities, proposed a bankruptcy sale of certain assets, including Personally Identifiable Information ("PII"). Deposition testimony in the case revealed that, over...more
In the latest example of the conflict between technological innovation and privacy concerns, the Federal Trade Commission (FTC) reached a settlement agreement last month with Nomi Technologies, Inc.
Nomi is a startup...more
The FCC has been warning communications companies for months that protecting consumer privacy and information security is a top priority, and the recent announcement of a $25 million settlement with AT&T over its alleged...more
Why it matters -
From the President to Senators to Representatives, everyone in Washington, D.C. appears to be focused on privacy-related issues. Continuing his focus on cybersecurity, President Barack Obama signed an...more
Taking another "step" toward developing comprehensive privacy legislation, the White House has released a discussion draft of the Consumer Privacy Bill of Rights Act of 2015. The draft reflects the Fair Information Practice...more
The White House released its much anticipated legislative proposal on the Consumer Privacy Bill of Rights Act (CPBRA) that was first floated in 2012. The CPBRA, if enacted (which seems unlikely before 2016), would provide...more
Although most states have enacted some form of data privacy and breach notification laws, and certain federal statutory schemes cover specific industry sectors, there are no privacy protections for all personal data. Given...more
In Part 1, we covered some basic privacy policy concepts. Here in Part 2, we address three problems associated with privacy policies in practice.
1. You Don't Have One, But You Really Should -
There is no...more
Between 2008 and 2010, hackers stole credit card information from the computer network of Wyndham Hotels & Resorts LLC ("Wyndham"), which affected hundreds of thousands of Wyndham's customers in the process. The Federal Trade...more
In October 2013, the IRS issued taxpayers a warning about a pervasive telephone scam designed to solicit payments and release of personal information from individuals. The IRS issued a second warning concerning the scam near...more
In a speech given before the Federal Trade Commission (FTC) on Monday, January 12, President Obama proposed federal legislation that would impose a nationwide standard on companies that experience a data security breach. The...more
On December 23, 2014, the Federal Trade Commission ("FTC") announced the filing of a complaint charging a data broker with selling the sensitive personal information of hundreds of thousands of consumers to third parties that...more
Companies with online sites and services that expressly target a young audience, such as websites and mobile apps providing entertainment, games or educational enrichment specifically oriented toward children, should already...more
In 2012, the FTC sued Wyndham and three of its subsidiaries after hackers broke into Wyndham's corporate computer system as well as systems at several of its individual hotels from 2008 to early 2010, resulting in exposure of...more
According to a Request for Investigation filed with the Federal Trade Commission ("FTC") on December 9, 2014, a coalition of consumer and children's privacy rights organizations has asked for a federal investigation of the...more
FCC Proposes Online Disclosures for Broadcast Contests -
The Federal Communications Commission has proposed a rule change that would allow broadcast stations to disclose on the Internet the material terms for contests...more
The long-brewing behind-the-scenes tensions of privacy, big data, and mobile finally came to a head last week in the public relations disaster known as #Ubergate. Uber's meteoric rise to the pinnacle of the rideshare start-up...more
On November 12, 2014, the Federal Trade Commission announced that the District Court for the District of Columbia had entered preliminary injunctions against two debt sellers which, together, had improperly posted personal...more
Companies that are looking to sell, transfer or buy personally identifiable information ("PII") via bankruptcy asset sales would be wise to confirm that such a transfer is consistent with the debtor's privacy policy. If it...more
The Federal Trade Commission ("FTC") has settled a complaint against consumer debt broker Bayview Solutions, LLC, as well as its principal, Aron Tomko, based on allegations that they had publicly disclosed the personal...more
On Jan. 1, 2015, California's "Online Eraser" law will take effect, requiring websites and other online service operators to delete on demand any content posted by minors. The law also prohibits such operators from sharing...more
Like it or not, the Federal Trade Commission (FTC) has injected itself into regulating and monitoring data privacy practices of corporations. Attorneys Seth Northrop and Richard Martinez discuss what this means for companies...more
In recent months, the Federal Trade Commission ("FTC") has been steadily ramping up its efforts to monitor, regulate, and provide best practice guidance in the rapidly expanding field of mobile applications. On September 10,...more
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Sandia to Partner with MOgene Green Chemicals on ARPA-E REMOTE Project
On September 19th, Advanced Research Projects Agency-Energy (ARPA-E) Deputy Director Cheryl Martin announced that 33 breakthrough energy projects will receive ~$66M from ARPA-E under two new programs that provide options for a more sustainable and secure American future.
REMOTE (Reducing Emissions using Methanotrophic Organisms for Transportation Energy) provides $34M to find advanced biocatalyst technologies that can […]
Permalink Gallery
Sandia Participates in the ARPA-E 2012 Energy Innovation Summit
Energy, Energy Assurance, Energy Efficiency, Energy Storage Systems, Energy Surety, Global Climate & Energy, Infrastructure Security, News, News & Events, Nuclear Energy, Photovoltaic, Renewable Energy, Solar, Transportation Energy, Wind Energy
Sandia Participates in the ARPA-E 2012 Energy Innovation Summit
Sandia has more than a dozen scientists and managers attending and participating in the ARPA-E summit's sessions and events. A recent highlight was the on-stage discussion between Energy Secretary Stephen Chu and Bill Gates, who is now involved in several energy innovation ventures, on how America can meet and prosper from 21st century global energy […]


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Tags indie, covers, indie rock, cover
Artists Pavement, My Morning Jacket, Arctic Monkeys
May 12, 2012
A few of my favorite covers! Enjoy!
Rocket Man by My Morning Jacket twice? Good playlist though :)
Thanks for the heads up! Fixed!! I obviously did not mean to do that! And thanks!!
I am really fucking indie by forbes5213
Random mix of catchy indie songs I've been into over the last year.
indie rock, indie pop, indie
Love is a Murderer by forbes5213
Some new.
indie, love songs, lost love
TAKE COVER! by forbes5213
A few of my favorite covers! Enjoy! .
indie, covers, indie rock, cover
Well! You just need to dive right on in there. You'll never know until you try it. by forbes5213
30 songs! I hope you find something you like.
indie, indie rock, indie electronic


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Gear Review
Simon Hatfield
More Hipbelt problems
I had the same problem as sch3082605 on a NOLS course, critical design failure in the hipbelt. Cracking in the main load bearing plastic support which shifted the load to flimsy support straps. Note that this occurred with a good condition pack borrowed from a friend on the 2nd day hiking with a 68lb load. The fact that Gregory will replace the pack doesn't help me very much when I'm already miles into the wilderness. Also, field repairs are impossible without a hex key, which is idiocy. I'll stick with Osprey.
Photo is of the break and my attempted repair, very difficult to access broken area so little could be done.
Peter Burke
I had the exact same thing fail, but after about 800 miles of hiking. Still, this happened 50+ miles from civilization, so the problem was serious. However, the pack still held together for another 150+ miles.
Another issue that has been coming up over the last 500 miles has been the lateral aluminum brace that connects the two vertical frame stays - it keeps wandering sideways and slips out of the fabric loops. Re-inserting that rod is extremely difficult. Without my titanium spork as a "shoehorn" I doubt I would have ever been able to field repair that.
Apart from that, I still think it's a darn good pack. Have to see if Gregory replaces the belt thing, but I don't have a receipt of the pack any longer... we'll see how their customer support is. Otherwise, I'll have to try a different brand pack.
Peter, how did Gregory customer service perform?
This happened to my Whitney twice, both times Gregory fixed and customer service was OK, Gregory will not pay for shipping to, but they will pay to send it back. I have had many miles on this pack, but I have an old Mountainsmith that I have had for just as long and its still in good shape. When the seams that hold the waist belt started to fail I got sick of sending this back every summer, its time to look at a different Manufacture.
View More Details on Gregory Whitney 95 Backpack - 5309-6285cu in


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- USDA offers funding for farmers markets, local food programs Updated: Jul-05-15 8:34 am
DES MOINES, Iowa - The U.S. Department of Agriculture's focus has traditionally been on food production, agriculture and natural resources but under the administration of President Barack Obama the USDA also has taken on a broader rural economic development role.
- Bangladesh-based poverty group founder wins World Food Prize Updated: Jul-01-15 2:28 pm
DES MOINES, Iowa - A man who created a nonprofit organization credited with helping more than 150 million people out of poverty was named the winner of the 2015 World Food Prize on Wednesday.
- $50 million in claims for grasslands fire Updated: Jun-30-15 12:32 pm
SIOUX FALLS, South Dakota - Ranchers and landowners filed more than $50 million in damage claims over a prescribed burn that veered out of control and burned 16,000 acres in North Dakota and South Dakota.
- Feds give California funds for drought aid, restoration Updated: Jun-24-15 6:31 pm
SACRAMENTO, California - Federal officials said Wednesday another $150 million would be provided to aid California drought aid programs.
- USDA program promotes products such as plant-based bottles Updated: Jun-17-15 6:52 pm
DES MOINES, Iowa - A program designed to promote ethanol and biodiesel fuels will be expanded to companies using plant-based plastic, rubber and fiber in manufacturing products such as bottles and packaging, the U.S. Agriculture Department said on Wednesday.
- Federal agencies pledge another $110 million in drought aid Updated: Jun-12-15 5:41 pm
SACRAMENTO, California - Federal agencies pledged another $110 million in aid Friday to help states struggling with the crippling drought after President Barack Obama talked to leaders from seven western states.
- House votes to repeal country-of-origin labeling on meat Updated: Jun-10-15 10:40 pm
WASHINGTON - House Republicans voted Wednesday to repeal a law requiring country-of-origin labels on packages of meat - a move to avoid costly trade retaliation from Canada and Mexico.
- Feds say Southwest, Northwest could see catastrophic fires Updated: Jun-09-15 7:46 pm
DENVER - Despite a wet spring over much of the nation, the Obama administration warned Tuesday of potentially catastrophic wildfires this summer, especially in the Southwest and Northwest.


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You are using an outdated browser. Please upgrade your browser to improve your ReverbNation experience.
Jan 9
Oct 12
Whether you like it or not, chances are Monsanto contaminated the food you ate today with chemicals and unlabeled GMOs. Monsanto controls much of the world's food supply at the expense of food democracy worldwide. This site is dedicated to empowering citizens of the world to take action against Monsanto & it's enablers like the FDA, USDA, EPA, GMA, BIO, and the processed food companies that use Monsanto's products. We urge you to help organize and attend the closest March Against Monsanto taking place on October 12, 2013 This is a Call to Action...
Oct 7
With the National Defense Authorization Act (NDAA) the goal was to ensure the government can secretly throw American citizens in jail for years or even decades without so much as ever giving them a trial! "Our Mission is to nonviolently block, strike down, repeal, stop, void and fight the indefinite detention provisions, Sections 1021 and 1022, of the National Defense Authorization Act for the Fiscal Year of 2012, to fight for American civil liberties, to combat laws restricting liberty in the interest of National Security, to support current government officials that are doing so and to engage a younger generation in the politics of the United States so this cannot happen again." -People Against National Defense Authorization Act
Aug 16
Come on over!
Apr 18
Sean Muniz
Kiki Vassilakis
Charles Pope
Electric Guitar
Sounds Like: Rage Against the Machine, DISPATCH, Sublime, Jason Mraz, Dirty Heads
Label: Independent, Rustic Justice Records
Manager: Jesse Calhoun firstname.lastname@example.com (937) 408 3075, Alphabetikal Productions
Bio: The Ameros are a rock, reggae, hip-hop, and funk powerhouse that combines thought-provoking lyrics, incendiary guitar, party vibes, and solid harmonies into a musical revolution. Their debut album, "Backs Against the Wall" was picked as one of the best of 2011 by the Daily Gazette in Schenectady...See Full Bio
: Been watching this for about 10 minutes... pretty interesting so far.... http://t.co/7VlWWRFxUt
"Next up was The Ameros, who opened with one of my favorite songs, "Ain't No Rest for the Wicked" by Cage the Elephant. This not only pumped me up but the rest of the crowd too, causing a massive surge to the front of the stage. Lead singer Jesse Calhoun belted out lyrics of freedom and rebellion with great passion and honesty, almost causing a riot on the dance floor. Charles Pope blew me away with his sharp guitar riffs especially during "New American Century." The Ameros musical style ranges from reggae, rock, funk and explosive hip hop. This was their second time playing at the MOVE Music Festival and Calhoun said it went way better this year since they got to play at one of their favorite venues, Valentines, and were able to support their friends' bands by catching more music too." Albany knows how to MOVE – recap of MOVE Music Festival, April 27th http://upstatelive.com/2013/05/06/albany-knows-how-to-move-recap-of-move-music-festival-april-27th/


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Timing The Storm: When Will Rain Return? And Just How Much Will We Get?
A cold storm system dropping down from the north will bring showers and possible thunderstorms to our area starting on Friday and ending on Sunday.
Final King Tides Of Season To Surge Bay Area Coastline Tuesday-Thursday
The Bay Area is about to get hit with the season's last round of high seas known as the "King Tides."
How Bad Is The Drought After That Latest Big Storm?
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13.68 Inches Of Rain Falls On Little-Known North Bay Town During Latest Storm
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Storm Wind Topples Massive Trees, Narrowly Missing Oakland Hills Home
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East Coast Winter Storm Prompts 22 Flight Cancellations At SFO
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Strong winds blew debris off a roof, hitting pedestrians on the head and forcing the temporary closure of Market Street in San Francisco.
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A brief break in the rain provided Bay Area residents with spectacular rainbows Sunday.
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A large tree branch and downed power lines closed state Highway 9 in Santa Clara County for about two hours Sunday afternoon, according to the CHP.


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Apolipoprotein E (apoE), a component of plasma lipoproteins, plays an important, but poorly defined role in sepsis. We have shown that injecting apoE increases septic mortality in a rat model of gram-negative bacterial sepsis, with concomitant hepatic natural killer T (NKT) cell proliferation and activation. The presumed mechanism for this apoE-mediated mortality is that apoE can bind and traffic antigens, presumed to include lipopolysaccharide (LPS), and promote activation of dendritic cells (DC) with subsequent NKT activation and cytokine release. Thus, we sought to prove that LPS was the antigen responsible for the increased NKT activation enhanced by the presence of apoE.
We isolated murine marrow-derived DCs, pulsed them with lipid antigen [LPS, and positve controls alpha-galactosylceramide (α-GalCer) and isogloboside 3 (iGb3)] with or without apoE, and then co-cultured the DCs with hybridoma NKTs. NKT activation was measured by interleukin-2 (IL-2) supernatant levels using ELISA.
LPS at different concentrations was a weak stimulus for NKT activation regardless of apoE presence. When apoE was present, iGb3, an endogenous ligand analog, elicited more than a two-fold increase in IL-2 response when compared to iGb3 alone (p<0.05).
These results indicate an endogenous ligand, not LPS, may be responsible for NKT activation. A molecular remnant similar to iGb3 could act as a damage-associated molecular pattern and play a prominent role in animal models of sepsis.
Apolipoprotein E (apoE) is a 34 kDa glycoprotein that plays an integral role in triglyceride-rich lipoprotein catabolism. Principally synthesized in the liver, apoE can also be found in the brain, kidneys and spleen. It consists of an amino terminal receptor and heparin binding domain, and a carboxy terminal lipid binding site. The three isoforms of apoE, each of which differ by a single amino acid, confer differential binding affinities for the low density lipoprotein receptor (LDLR) (E4>E3>>>E2), which explains the hypertriglyceridemia found in E2 carriers[1].
ApoE was initially recognized for its role in lipoprotein metabolism, but has since been associated with cardiovascular disease and Alzheimer's disease. The E4 isoform has been linked to both, with increased plaque formation and decreased lipid clearance contributing to atherosclerosis, and enhanced neurofibrillary tangle formation promoting Alzheimer's progression in the brain. Neither mechanism is completely understood, but inflammation is believed to contribute significantly.
Only recently has the link between apoE and sepsis been investigated. Consistent with its ability to facilitate the clearance of triglyceride-rich lipoproteins by the liver, apoE has been shown both to redirect lipopolysaccharide (LPS) from Kupffer cells to hepatocytes and to protect against endotoxemia in rats [2]. ApoE–knockout mice are also more susceptible to LPS-induced lethality than are controls, despite elevated plasma lipid levels [3]. Similarly, when given intravenously, apoE has been shown to decrease LPS-induced morbidity and mortality in mice and has thus been identified to have anti-infective properties [4]. But, quite unexpectedly, our laboratory has recently discovered that infusion of apoE increased rather than decreased mortality after cecal ligation and puncture (CLP), an in vivo model of gram-negative bacterial sepsis [5] (Figure 1).
Interestingly, apoE has recently been implicated in the activation of Natural Killer T (NKT) cells by acting as a molecular chaperone for bacterial antigens, delivering them to antigen-presenting dendritic cells (DCs) via LDLR to activate NKT cells by CD1d, a nonclassical class-I-like antigen-presenting molecule (Figure 2) [6]. Predominantly located in the liver, activated NKT cells can secrete large amounts of TH1 and TH2 cytokines and appear to serve as a bridge between innate and acquired immunity [7]. When we investigated the NKT cell response in septic mice treated with apoE, we found that apoE infusion resulted in increased NKT number and proliferation, predominantly in the liver, with concomitant decreases in NKT cell number and proliferation in the periphery, implying hepatic trafficking [4]. ApoE treatment also increased TH1 response and NKT-induced hepatocellular injury. Taken together, these observations support apoE as making a significant contribution to host defense against infection by regulating the processing of lipid antigens during sepsis, and by activating NKT cells. These observations, unlike those from previous studies [2-4], argue against a protective role for apoE, possibly because we used serial injections of apoE in our CLP model of sepsis, whereas earlier studies used an injection of LPS and demonstrated protection by pre-incubating LPS with apoE before injection.
To determine whether the observed hyperactive inflammatory response induced by apoE infusion in wild type mice was physiologically relevant, we recently performed a series of experiments showing that hypomorphic apoE transgenic mice expressing 2-5% of wild-type levels of apoE level are less susceptible to septic mortality than their induced, wild-type counterparts [unpublished data]. These findings appear to validate the pro-inflammatory contribution that apoE makes in sepsis. They also indicate that a subphysiologic level of apoE may be ideal in the face of sepsis. With all the findings to date, it appears that apoE may regulate a delicate counterbalance between sufficient systemic inflammation to clear the invading pathogen, yet insufficient to harm the host in the process of eradicating the infection.
In an effort to define apoE's role in lipid antigen presentation, we conducted in vitro studies looking at NKT cell activation in the presence of dendritic cells co-incubated with various lipid antigens with apoE present or absent. We found that apoE plays no role in enhancing LPS presentation and immune activation in our in vitro system. Instead, we discovered that apoE enhances endogenous lipid antigen presentation and subsequent NKT cell activation. Our results have forced us to take a closer look at the murine model of sepsis and to redefine apoE's role as promoting damage-associated molecular pattern (DAMP) activation of host immunity rather than activation via pathogen-associated molecular patterns (PAMPs), like LPS.
A protocol adapted from Lutz et al. was used to isolate murine bone marrow-derived dendritic cells (BMDCs) [8]. Bone marrow cells were harvested from femurs and tibias of 3-20 week-old female C57BL/6J mice (Charles River Laboratories, Wilmington, MA). Bone epiphyses were cut and the marrow was flushed out with a 25G needle and syringe. Cells were disaggregated with vigorous pipetting and filtered through a 70 μm nylon cell strainer. Cells were washed and seeded in 100 mm bacteriological petri dishes. Cell culture medium (R10) was RPMI-1640 containing 100 U/ml penicillin and 100 μg/ml streptomycin, 2 mM L-glutamine, and 10% heat-inactivated FCS (all from Sigma-Aldrich, St. Louis, MO). Complete R10 medium was supplemented with culture supernatant from NIH-3T3 cells transfected with the murine GM-CSF gene (a generous gift from S.-M. Kang, UCSF).
On day 0, bone marrow leukocytes were seeded at 2-3 × 106 cells per 100 mm dish in 10 ml R10 medium containing 20 ng/ml GM-CSF. On day 3, an additional 10ml of R10 containing 20 ng/ml GM-CSF was added to the plates. On days 6 and 8, half of the cell culture supernatant was collected and centrifuged; the cell pellet was resuspended in 10 ml R10 containing 20 ng/ml GM-CSF, and returned to the original plates. On day 9, non-adherent cells were collected by gentle pipetting, resuspended in fresh R10 containing 10 ng/ml GM-CSF, and plated into 100 mm tissue culture plastic dishes.
Hepatocytes were isolated from 10-16 week-old C57BL/6J mice. Via the portal vein, the liver was perfused with 20 ml of liver perfusion medium (Life Technologies, Rockville, MD) followed by 5 ml of liver digestion medium (Life Technologies). The liver was removed and pressed through mesh. The liver cell suspension was collected and parenchymal cells were separated from the mononuclear cells by centrifugation at 50 X g for 5 minutes. Hepatocytes were washed twice in complete RPMI 1640 and resuspended in RPMI 1640 supplemented with 5% FCS (Life Technologies).
Bone-marrow-derived dendritic cells were then pulsed with antigens for 24 hours; 1, 10, and 100 μg/ml LPS (Sigma-Aldrich), 100 ng/ml iGb3 (Axxora, San Diego, CA.), 100 ng/ml α-GalCer (Axxora), heat-killed aerobic and anaerobic bacteria (70° C for 1 hour, 1×108 bacteria/ml) or vehicle controls, with or without 1.63 μg/ml recombinant apolipoprotein E (produced in bacteria expressing thioredoxin fusion protein as previously described [9]). Glycolipid antigens were dissolved in chloroform:methanol (2:1 ratio) and stored at −20°C. Aliquots from this stock were dried and iGb3 was reconstituted in methanol, whereas α-GalCer was reconstituted in DMSO (Sigma-Aldrich).
DN32 NKT hybridomas (a generous gift from A. Bendelac, University of Chicago) were maintained in 50% EHAA medium (Invitrogen, Carlsbad, CA.) and 50% RPMI-1640 medium supplemented with 100 U/ml penicillin and 100 μg/ml streptomycin, 2 mM L-glutamine, 10% heat-inactivated FCS, 50 μM β-ME, and 25μg/ml gentamycin (Sigma-Aldrich). Twenty-four hours after antigenic stimulation, BMDCs were washed and co-cultured with DN32 NKT cell hybridomas at a 1:1 ratio in 96-well flat bottom plates for 24 hours. Supernatants were collected after 24 hours of culture for cytokine determination. Hepatocytes were stimulated in a similar manner as described in Trobonjaca et al. [10]
Co-culture supernatants were assayed for IL-2 production by ELISA (R&D, Minneapolis, MN.).
Differences between groups were analyzed using Student's t-test. Two-sided P values < 0.05 were considered statistically significant.
ApoE presumably contributes to host defense against infection by binding exogenous lipid antigens and targeting them for receptor-mediated uptake by DCs. DCs then present the antigen to NKT cells, resulting in a cytokine response [6]. In gram-negative bacterial sepsis, the lipid antigen in question is assumed to be LPS. Therefore, we sought to establish a dose-response relationship between LPS and NKT cytokine response. In our experiments, BMDCs were pulsed with varying doses of LPS (1, 10, 100 ug/mL) for 24 hours, after which the unbound LPS was washed away and the DCs were co-cultured with DN32 NKT hybridoma cells for an additional 24 hours. The IL-2 levels in the supernatant were measured using ELISA. IL-2 was chosen as our index of NKT hybridoma activation based on findings by Bendelac et al., who noted robust CD1-dependent IL-2 production after thymocytes were stimulated [11]. We found that LPS alone elicited minimal cytokine response. Surprisingly, adding apoE failed to enhance the NKT response to LPS regardless of LPS dose (Figure 3). This suggests that apoE enhances inflammation through another unidentified lipid antigen, and not through LPS.
Since purified LPS did not appear to be the primary antigen that apoE presents, we wanted to confirm that LPS in the "reactive" state within the bacterial cell wall was not responsible for initiating apoE-mediated inflammation. For this experiment, we incubated DCs with heat-killed bacteria for several time periods (1, 3, 6, 24 hours), which resulted in lower IL-2 levels with longer incubation periods. When apoE was added to the heat-killed bacteria, IL-2 levels did not change significantly (data not shown). The results of this experiment indicate that although bacterial antigens caused a time-dependent decrease in cytokine levels, apoE was not involved in their enhanced presentation to NKTs.
Since LPS in the purified and natural states did not appear to be the apoE binding agents, we next sought to determine the role of endogenous ligands in apoE-mediated inflammation. Isoglobotrihexosylceramide (iGb3), a glycosphingolipid found in rat cancer cell lines and rat intestine, is a weak agonist for human and mouse NKT cells, as well as for NKT hybridomas [12]. As expected, when we used iGb3 as our endogenous ligand analog, adding it to DCs induced a moderate NKT cell response. Adding apoE to the media resulted in more than a 2-fold increase in IL-2 concentration (Figure 4). These results suggest that apoE may facilitate NKT cell activation by the endogenous antigen, iGb3. The potent NKT cell agonist alpha-galactosyl ceramide (α-GC) served as a positive control in our in vitro system. Its presence induced a robust NKT cell IL-2 response. The presence of apoE did not significantly alter this response (Figure 4).
Hepatocytes themselves, along with NKT cells and DCs in the liver, have been implicated in CD1d-based antigen presentation [10,13]. To determine whether the apoE-mediated antigen presentation was unique to DCs, we isolated hepatocytes from B6 mice and exposed them for 2 hours to various antigens with or without apoE. As before, cells were washed and then co-cultured with DN32 NKT cells. We found that IL-2 release was moderate 24 hours after cells were stimulated with LPS, α-GC and iGb3. The presence of apoE did not stimulate further IL-2 release (Figure 5). Therefore, we did not demonstrate a role for hepatocytes as antigen presenting cells in the presence of apoE-chaperoned lipid antigens in our in vitro assay system.
Our previous work demonstrated that apoE enhances the immune response to gram-negative bacterial sepsis via increased NKT cell activation and TH1 cytokine response. These initial findings were consistent with apoE's having been implicated in lipid antigen presentation to NKT cells via the class-I-like antigen-presenting molecule CD1d [6]. Our current study provides evidence that LPS is not the primary agent responsible for apoE-enhanced NKT cytokine elaboration during sepsis. Instead, apoE appears to enhance the presentation of an endogenous ligand, iGb3, to DCs for processing and re-presentation to NKT cells.
The cytokine-induced hyperlipoproteinemia following endotoxin exposure, the "lipemia of sepsis," is now understood to be the body's effort to decrease the bioavailability of LPS through direct neutralization and increased catabolism with subsequent hepatic clearance. With its ability to bind LPS via a large C-terminal lipid-binding domain, apoE is thought to play a critical role in endotoxin neutralization and transport. These properties support an anti-infective role for apoE that was corroborated by initial studies showing decreased LPS-induced mortality as a function of either endogenous or exogenous apoE levels [3,4]. But, recent in vivo studies linking increased inflammation and mortality in the more clinically relevant model of sepsis, CLP, together with in vitro studies implicating apoE as a lipid antigen-presenting agent, allude to its critical role in immunomodulation [5,6].
Our current findings contradict previous assumptions that LPS was the primary protagonist in the NKT-mediated pathway. Moreover, they suggest that apoE is not involved in enhancing the presentation of LPS to antigen-presenting cells and promoting inflammation. Instead, the classic TLR4 pathway may play a more prominent role in the direct inflammatory response to LPS in the in vivo setting. Likewise, heat-killed bacteria failed to elicit an impressive IL-2 response with or without apoE, ruling out non-LPS bacterial antigens as the NKT-inciting agent. Our search for this elusive agent led to our interest in the endogenous lipid antigen iGb3, a principal self-antigen of NKT cells and a weak agonist of NKT hybridomas and human and mouse NKT cells [14].
Natural Killer T cells have several indirect pathways of pathogen activation all mediated by DCs. In instances where exogenous antigen activation of DCs is insufficient to generate appropriate NKT cell activation, recognition of endogenous ligand by T-cell receptor is required [15]. Our findings suggest a novel mechanism by which apoE can bind iGb3, and perhaps other endogenous ligands, and deliver it by receptor-mediated uptake into endosomal compartments containing CD1, where it can be presented to NKT cells. Such a mechanism is in line with the theory that apoE hyperactivates the immune system.
The potential role of endogenous ligands in apoE-mediated septic mortality compelled us to take a second look at the classic murine model of sepsis, CLP, and the role that apoE plays in increasing septic mortality. Although the primary insult in CLP appears to be induction of fecal peritonitis and subsequent LPS-mediated inflammation (PAMPs), the traumatic ligation and puncture of the cecum could result in the release of endogenous ligands (DAMPs) and contribute significantly to inflammation as well. Our in vitro findings indicate that antigen presentation is more prominent with endogenous ligands than with LPS. The contribution of DAMPs to DC and NKT cell activation is not unprecedented, having been studied in attempts to develop immunotherapies against malignancies [16].
Our study was not the first attempt to link iGb3 presentation and sepsis. Mattner et al. showed that Hexb (iGb3 synthesis enzyme) KO mice were unable to clear infectious bacteria, and that Hexb KO DCs exposed to LPS were deficient in stimulating NKT cells when compared to wild type DCs [17]. In addition, microbial stimulation of CD1+ APC's resulted in upregulation of glycolipid antigen synthesis [18]. How iGb3 is presented is poorly understood, but the LDLR is required for presentation of exogenous lipid antigens. Under physiological conditions, iGb3 can be internalized by DCs presumably via the LDLR, the same receptor that takes up apoE [12]. Thus, apoE, which binds LDLR with high affinity, presumably could enhance uptake of iGb3 (or similar ligands), which binds LDLR with presumably less affinity.
We believe our choice of iGb3 as our model of an endogenous ligand can be justified based on the existing literature. Biochemical evidence for iGb3 expression has been found in several mammalian species including rat intestine, the tissue that is damaged during CLP [19-23]. Although humans express the iGb3 synthase gene, it has not been purified from human tissue [24]. Despite the inability to isolate iGb3 from human cells, it is still recognized by human NKT cells and provokes robust IFN-γ secretion [14]. It appears that iGb3, or a close structural analog, is the principal self antigen of NKT cells.
In conclusion, our study provides evidence that apoE can increase NKT cell activation by enhancing endogenous ligand presentation. This finding builds upon recent evidence that apoE plays an immunomodulatory role in sepsis. It will be interesting to define the relative contribution of apoE presentation of endogenous ligands and pathogens to septic mortality, using limb ischemia reperfusion and intravenous LPS administration as model systems for each component. Protection from bacterial sepsis by means of apoE antagonism may hold more promise than previous anti-cytokine therapies because apoE can potentially act on pathogen-associated and damage-associated molecular patterns, two separate instigators of the host immune response during sepsis.
Apolipoprotein E, a component of plasma lipoproteins, plays an important, but poorly defined role in sepsis. We pulsed dendritic cells with various lipid antigens in the presence or absence of apolipoprotein E, and then co-cultured these cells with NKT cells and determined NKT activation using ELISA. The results of this provide evidence that apoE can increase NKT cell activation by enhancing endogenous ligand presentation.
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Every school has one. The kid who teases everyone in the classroom. The one who pushes others around — literally and figuratively. The boy who the students say is a bully. We all pray that our son won't become a victim, but what if your little guy is the one doing the attacking? You may think, "no, not my son," but it's possible that love makes you blind to his bad behavior. So how can you tell if he is a bully? We rounded up seven classic signs that your son is the boy all his classmates fear.
I read this article and was like... dude, they just described my kid, sans 1 of the items. Then I thought about it more and I was like... hold on, this describes MOST autistic kids.
My son is autistic so I've done a ton of research regarding the condition. He's in 6th grade and he gets picked on because he acts a bit off, to some, is super short and he talks funny because of a speech delay, he's also super smart at most things that a lot of kids aren't like math and science... It's like he has a bully magnet strapped to his behind. Sadly in our society being even a little different is cause for torment :(
Thank you for bringing this issue to attention as it is imperative to address it asap...although this can also be due to a way of getting attention, teasing siblings, and shock therapy ( to parents ) are commonly used. Regular discussions with your children one on one is an excellent way to discovering how and why they interpret and react as they do.
Evidently you hit a nerve on this one...thus the feedback you rec'd...good write...
Lol I thought that, my son is ADHD with ASD traits (being assessed for the latter) and he's been bullied through school by children who are true bullies because he sticks out like a sore thumb.
This list applies to boys and girls. This is not unique to boys. The only difference I would say is in the acceptance of aggressive behaviour. I have seen so many parents accept their sons behavior as "boys will be boys:" rather than blatant aggressive behaviour. Tackling, wrestling and general very tactical behavior is not acceptable and should not be encouraged as boy behavior.